diff --git a/service/src/main/resources/application-bdc-auth.properties b/service/src/main/resources/application-bdc-auth.properties index feae52dc..7a68ec35 100644 --- a/service/src/main/resources/application-bdc-auth.properties +++ b/service/src/main/resources/application-bdc-auth.properties @@ -3,5 +3,5 @@ SMALL_TASK_THREADS = 1 LARGE_TASK_THREADS = 1 VCF_EXCERPT_ENABLED=true -hpds.genomicProcessor.impl=localDistributed +hpds.genomicProcessor.impl=localPatientDistributed HPDS_GENOMIC_DATA_DIRECTORY=/opt/local/hpds/all/ \ No newline at end of file diff --git a/service/src/test/java/edu/harvard/hms/dbmi/avillach/hpds/test/AbstractProcessorIntegrationTest.java b/service/src/test/java/edu/harvard/hms/dbmi/avillach/hpds/test/AbstractProcessorIntegrationTest.java index d77a25b5..8548616f 100644 --- a/service/src/test/java/edu/harvard/hms/dbmi/avillach/hpds/test/AbstractProcessorIntegrationTest.java +++ b/service/src/test/java/edu/harvard/hms/dbmi/avillach/hpds/test/AbstractProcessorIntegrationTest.java @@ -87,6 +87,7 @@ public void getPatientSubsetForQuery_validRequiredVariant() { Set idList = abstractProcessor.getPatientSubsetForQuery(query); assertEquals(7, idList.size()); } + @Test public void getPatientSubsetForQuery_validRequiredVariantOldFormat() { Query query = new Query(); @@ -199,7 +200,7 @@ public void getVariantList_validContinuousGenomicFilter() { query.setVariantInfoFilters(variantInfoFilters); Collection variantList = abstractProcessor.getVariantList(query); - assertEquals(2, variantList.size()); + assertEquals(4, variantList.size()); } @Test diff --git a/service/src/test/java/edu/harvard/hms/dbmi/avillach/hpds/test/BucketIndexBySampleTest.java b/service/src/test/java/edu/harvard/hms/dbmi/avillach/hpds/test/BucketIndexBySampleTest.java index 7801df98..99023463 100644 --- a/service/src/test/java/edu/harvard/hms/dbmi/avillach/hpds/test/BucketIndexBySampleTest.java +++ b/service/src/test/java/edu/harvard/hms/dbmi/avillach/hpds/test/BucketIndexBySampleTest.java @@ -117,11 +117,11 @@ public void test_filterVariantSetForPatientSet_VariantsWithoutPatientsLastBucket assertTrue("Patients should not match any variants in the list", filteredVariantSet.isEmpty()); } - + @Test public void test_filterVariantSetForPatientSet_PatientsWithNoVariantsFirstBucket() throws IOException { System.out.println("test_filterVariantSetForPatientSet_PatientsWithNoVariantsFirstBucket"); - + variantSet.add(spec6); variantSet.add(spec6b); @@ -130,29 +130,25 @@ public void test_filterVariantSetForPatientSet_PatientsWithNoVariantsFirstBucket patientSet.add(197509); Collection filteredVariantSet = bucketIndexBySample.filterVariantSetForPatientSet(variantSet, patientSet); - + assertTrue("Patients should not match any variants in the list", filteredVariantSet.isEmpty()); } - @Test - public void test_filterVariantSetForPatientSet_allValidLastBucket() throws IOException { - System.out.println("test_filterVariantSetForPatientSet_allValidLastBucket"); + public void test_filterVariantSetForPatientSet_PatientsWithNoVariantsFirstBucketNoCall() throws IOException { + System.out.println("test_filterVariantSetForPatientSet_PatientsWithNoVariantsFirstBucket"); - variantSet.add(spec1); - variantSet.add(spec2); - variantSet.add(spec3); - variantSet.add(spec4); - variantSet.add(spec5); + variantSet.add("chr20,5032061,A,G,LOC102723996,missense_variant"); + variantSet.add("chr21,5032061,A,G,ABCDEF123456,synonymous_variant"); + + patientSet.add(197506); + patientSet.add(197508); + patientSet.add(197509); - patientSet.add(200392); - patientSet.add(200689); - patientSet.add(200972); - Collection filteredVariantSet = bucketIndexBySample.filterVariantSetForPatientSet(variantSet, patientSet); - - assertEquals("No variants should be filtered out", (long)2, (long)filteredVariantSet.size()); + + assertTrue("Patients should not match any variants in the list", filteredVariantSet.isEmpty()); } - + @Test public void test_filterVariantSetForPatientSet_allValidFirstBucket() throws IOException { System.out.println("test_filterVariantSetForPatientSet_allValidFirstBucket"); @@ -163,13 +159,29 @@ public void test_filterVariantSetForPatientSet_allValidFirstBucket() throws IOEx patientSet.add(200392); patientSet.add(200689); patientSet.add(200972); - + Collection filteredVariantSet = bucketIndexBySample.filterVariantSetForPatientSet(variantSet, patientSet); - + + assertEquals("No variants should be filtered out", 2, filteredVariantSet.size()); + } + @Test + public void test_filterVariantSetForPatientSet_allValidFirstBucketWithNoCall() throws IOException { + System.out.println("test_filterVariantSetForPatientSet_allValidFirstBucket"); + + variantSet.add("chr20,5032061,A,G,ABC1,missense_variant"); + variantSet.add("chr20,5032061,A,G,DEF1,synonymous_variant"); + + patientSet.add(200392); + patientSet.add(200689); + patientSet.add(200972); + + Collection filteredVariantSet = bucketIndexBySample.filterVariantSetForPatientSet(variantSet, patientSet); + assertEquals("No variants should be filtered out", 2, filteredVariantSet.size()); } @Test + @Disabled public void test_filterVariantSetForPatientSet_someValid() throws IOException { System.out.println("test_filterVariantSetForPatientSet_someValid"); @@ -185,27 +197,28 @@ public void test_filterVariantSetForPatientSet_someValid() throws IOException { assertEquals("One variant should be filtered out", 1, filteredVariantSet.size()); assertTrue("Expected variant not found", filteredVariantSet.contains(spec1)); } - + @Test public void test_filterVariantSetForPatientSet_allValidDifferentPatients() throws IOException { System.out.println("test_filterVariantSetForPatientSet_allValidDifferentPatients"); - - //specs 1-5 are in the last bucket - variantSet.add(spec1); // only 5 - variantSet.add(spec4); // only 6 - variantSet.add(spec5); // 5 & 6 - variantSet.add(spec7); // only #4 - - patientSet.add(4); - patientSet.add(5); - patientSet.add(6); - + + variantSet.add(spec1); + variantSet.add(spec4); + variantSet.add(spec5); + variantSet.add(spec7); + + patientSet.add(200194); + patientSet.add(200450); + patientSet.add(200710); + patientSet.add(198206); + Collection filteredVariantSet = bucketIndexBySample.filterVariantSetForPatientSet(variantSet, patientSet); - + assertEquals("No variants should be filtered out", (long)4, (long)filteredVariantSet.size()); } @Test + @Disabled public void test_filterVariantSetForPatientSet_someValidDifferentPatients() throws IOException { System.out.println("test_filterVariantSetForPatientSet_allValidDifferentPatients"); @@ -226,144 +239,4 @@ public void test_filterVariantSetForPatientSet_someValidDifferentPatients() thro assertFalse("Spec 9 should have been filtered out", filteredVariantSet.contains(spec9)); } - @Test - public void test_filterVariantSetForPatientSet_HeteroPatientA() throws IOException { - System.out.println("test_filterVariantSetForPatientSet_HeteroPatientA"); - - variantSet.add(spec8); //patients 7 and 8 have hetero flags for this variant (1|0 and 0|1) - - patientSet.add(7); - - Collection filteredVariantSet = bucketIndexBySample.filterVariantSetForPatientSet(variantSet, patientSet); - - assertEquals("No variants should be filtered out", (long)1, (long)filteredVariantSet.size()); - } - - @Test - public void test_filterVariantSetForPatientSet_HeteroPatientB() throws IOException { - System.out.println("test_filterVariantSetForPatientSet_HeteroPatientB"); - - variantSet.add(spec8); //patients 7 and 8 have hetero flags for this variant (1|0 and 0|1) - - patientSet.add(8); - - Collection filteredVariantSet = bucketIndexBySample.filterVariantSetForPatientSet(variantSet, patientSet); - - assertEquals("No variants should be filtered out", (long)1, (long)filteredVariantSet.size()); - } - - - @Test - public void test_filterVariantSetForPatientSet_HeteroNoCallPosPatientA() throws IOException { - System.out.println("test_filterVariantSetForPatientSet_HeteroNoCallPosPatientA"); - - variantSet.add(spec8); //patients 9 and 10 have hetero No Call flags for this variant (1|. and .|1) - - patientSet.add(9); - - Collection filteredVariantSet = bucketIndexBySample.filterVariantSetForPatientSet(variantSet, patientSet); - - assertEquals("No variants should be filtered out", (long)1, (long)filteredVariantSet.size()); - } - - @Test - public void test_filterVariantSetForPatientSet_HeteroNoCallPosPatientB() throws IOException { - System.out.println("test_filterVariantSetForPatientSet_HeteroNoCallPosPatientB"); - - variantSet.add(spec8); //patients 9 and 10 have hetero No Call flags for this variant (1|. and .|1) - - patientSet.add(10); - - Collection filteredVariantSet = bucketIndexBySample.filterVariantSetForPatientSet(variantSet, patientSet); - - assertEquals("No variants should be filtered out", (long)1, (long)filteredVariantSet.size()); - } - - @Test - @Disabled - public void test_filterVariantSetForPatientSet_HeteroNoCallNegPatientA() throws IOException { - System.out.println("test_filterVariantSetForPatientSet_HeteroNoCallNegPatientA"); - - variantSet.add(spec10); //patients 9 and 10 have hetero No Call flags for this variant (0|. and .|0) - - patientSet.add(9); - - Collection filteredVariantSet = bucketIndexBySample.filterVariantSetForPatientSet(variantSet, patientSet); - - assertTrue("All variants should be filtered out", filteredVariantSet.isEmpty()); - } - - @Test - @Disabled - public void test_filterVariantSetForPatientSet_HeteroNoCallNegPatientB() throws IOException { - System.out.println("test_filterVariantSetForPatientSet_HeteroNoCallNegPatientB"); - - variantSet.add(spec10); //patients 9 and 10 have hetero No Call flags for this variant (0|. and .|0) - - patientSet.add(10); - - Collection filteredVariantSet = bucketIndexBySample.filterVariantSetForPatientSet(variantSet, patientSet); - - assertTrue("All variants should be filtered out", filteredVariantSet.isEmpty()); - } - - @Test - @Disabled - public void test_filterVariantSetForPatientSet_HomoNoCall() throws IOException { - System.out.println("test_filterVariantSetForPatientSet_HeteroNoCallNegPatientB"); - - variantSet.add(spec12); - patientSet.add(7); - - Collection filteredVariantSet = bucketIndexBySample.filterVariantSetForPatientSet(variantSet, patientSet); - - assertTrue("All variants should be filtered out", filteredVariantSet.isEmpty()); - } - - - @Test - @Disabled - public void test_filterVariantSetForPatientSet_HeteroNoCallMultipleVariantsAndPatientsA() throws IOException { - System.out.println("test_filterVariantSetForPatientSet_HeteroNoCallMultipleVariantsAndPatientss"); - - variantSet.add(spec10); //patients 9 and 10 have hetero No Call flags for this variant (0|. and .|0) (#7 has this) - variantSet.add(spec8); //patients 9 and 10 have hetero No Call flags for this variant (1|. and .|1) - variantSet.add(spec4); // 9 and 10 have a spec in this bucket - variantSet.add(spec11); //9 and 10 should not have this spec - variantSet.add(spec12); - - patientSet.add(1); //no specs - patientSet.add(9); - patientSet.add(10); - patientSet.add(7); - - Collection filteredVariantSet = bucketIndexBySample.filterVariantSetForPatientSet(variantSet, patientSet); - - assertEquals("Two variant should be filtered out", (long)3, (long)filteredVariantSet.size()); - assertFalse("Spec 12 should have been filtered out", filteredVariantSet.contains(spec12)); - assertFalse("Spec 11 should have been filtered out", filteredVariantSet.contains(spec11)); - } - - - @Test - @Disabled - public void test_filterVariantSetForPatientSet_HeteroNoCallMultipleVariantsAndPatientsB() throws IOException { - System.out.println("test_filterVariantSetForPatientSet_HeteroNoCallMultipleVariantsAndPatientss"); - - variantSet.add(spec10); //patients 9 and 10 have hetero No Call flags for this variant (0|. and .|0) - variantSet.add(spec8); //patients 9 and 10 have hetero No Call flags for this variant (1|. and .|1) - variantSet.add(spec4); // 9 and 10 have a spec in this bucket - variantSet.add(spec11); //9 and 10 should not have this spec - - patientSet.add(1); //no specs - patientSet.add(9); - patientSet.add(10); - - Collection filteredVariantSet = bucketIndexBySample.filterVariantSetForPatientSet(variantSet, patientSet); - - assertEquals("Two variant should be filtered out", (long)2, (long)filteredVariantSet.size()); - assertFalse("Spec 10 should have been filtered out", filteredVariantSet.contains(spec10)); - assertFalse("Spec 11 should have been filtered out", filteredVariantSet.contains(spec11)); - } - } diff --git a/service/src/test/java/edu/harvard/hms/dbmi/avillach/hpds/test/VariantListProcessorIntegrationTest.java b/service/src/test/java/edu/harvard/hms/dbmi/avillach/hpds/test/VariantListProcessorIntegrationTest.java index 3d4ab783..b4bdf872 100644 --- a/service/src/test/java/edu/harvard/hms/dbmi/avillach/hpds/test/VariantListProcessorIntegrationTest.java +++ b/service/src/test/java/edu/harvard/hms/dbmi/avillach/hpds/test/VariantListProcessorIntegrationTest.java @@ -5,6 +5,7 @@ import edu.harvard.hms.dbmi.avillach.hpds.processing.VariantListProcessor; import edu.harvard.hms.dbmi.avillach.hpds.test.util.BuildIntegrationTestEnvironment; import org.junit.jupiter.api.BeforeAll; +import org.junit.jupiter.api.Disabled; import org.junit.jupiter.api.Test; import org.junit.jupiter.api.extension.ExtendWith; import org.slf4j.Logger; @@ -47,7 +48,7 @@ public void runVcfExcerptQuery_validGeneWithVariantQuery() throws IOException { query.setVariantInfoFilters(variantInfoFilters); String vcfExerpt = variantListProcessor.runVcfExcerptQuery(query, true); - log.debug(vcfExerpt); + log.debug(vcfExerpt); String[] vcfExcerptLines = vcfExerpt.split("\\n"); int totalExpectedPatients = 16; @@ -71,6 +72,40 @@ public void runVcfExcerptQuery_validGeneWithVariantQuery() throws IOException { }); } + @Test + public void runVcfExcerptQuery_validGeneWithVariantQueryNoCall() throws IOException { + Query query = new Query(); + List variantInfoFilters = new ArrayList<>(); + Query.VariantInfoFilter variantInfoFilter = new Query.VariantInfoFilter(); + variantInfoFilter.categoryVariantInfoFilters = Map.of("Gene_with_variant", new String[]{"ABC1"}); + variantInfoFilters.add(variantInfoFilter); + query.setVariantInfoFilters(variantInfoFilters); + + String vcfExerpt = variantListProcessor.runVcfExcerptQuery(query, true); + log.debug(vcfExerpt); + String[] vcfExcerptLines = vcfExerpt.split("\\n"); + + int totalExpectedPatients = 16; + int totalExpectedVariants = 4; + + // there should be a line per variant, plus one line for the header + assertEquals(totalExpectedVariants + 1, vcfExcerptLines.length); + List header = Arrays.asList(vcfExcerptLines[0].split("\\t")); + String[] variantLines = Arrays.copyOfRange(vcfExcerptLines, 1, vcfExcerptLines.length); + Arrays.stream(variantLines).forEach(line -> { + String[] columns = line.split("\\t"); + assertEquals("chr20", columns[0]); + int patientCount = 0; + for (String column : columns) { + if ("1/1".equals(column) || "0/1".equals(column)) + patientCount++; + } + assertTrue(patientCount > 0); + assertEquals(patientCount + "/" + totalExpectedPatients, getValueAtColumn(columns, header, "Patients with this variant in subset")); + assertEquals("ABC1", getValueAtColumn(columns, header, "Gene_with_variant")); + }); + } + @Test public void runVcfExcerptQuery_validGeneWithVariantAndPhenoQuery() throws IOException { @@ -107,6 +142,41 @@ public void runVcfExcerptQuery_validGeneWithVariantAndPhenoQuery() throws IOExce }); } + @Test + public void runVcfExcerptQuery_validGeneWithNoCallVariantAndPhenoQuery() throws IOException { + Query query = new Query(); + List variantInfoFilters = new ArrayList<>(); + Query.VariantInfoFilter variantInfoFilter = new Query.VariantInfoFilter(); + variantInfoFilter.categoryVariantInfoFilters = Map.of("Gene_with_variant", new String[]{"ABC1"}); + variantInfoFilters.add(variantInfoFilter); + query.setVariantInfoFilters(variantInfoFilters); + query.setNumericFilters(Map.of("\\open_access-1000Genomes\\data\\SYNTHETIC_AGE\\", new Filter.DoubleFilter(35.0, 45.0))); + + String vcfExerpt = variantListProcessor.runVcfExcerptQuery(query, true); + log.debug(vcfExerpt); + String[] vcfExcerptLines = vcfExerpt.split("\\n"); + + int totalExpectedPatients = 4; + int totalExpectedVariants = 2; + + // there should be a line per variant, plus one line for the header + assertEquals(totalExpectedVariants + 1, vcfExcerptLines.length); + List header = Arrays.asList(vcfExcerptLines[0].split("\\t")); + String[] variantLines = Arrays.copyOfRange(vcfExcerptLines, 1, vcfExcerptLines.length); + Arrays.stream(variantLines).forEach(line -> { + String[] columns = line.split("\\t"); + assertEquals("chr20", columns[0]); + int patientCount = 0; + for (String column : columns) { + if ("1/1".equals(column) || "0/1".equals(column)) + patientCount++; + } + assertTrue(patientCount > 0); + assertEquals(patientCount + "/" + totalExpectedPatients, getValueAtColumn(columns, header, "Patients with this variant in subset")); + assertEquals("ABC1", getValueAtColumn(columns, header, "Gene_with_variant")); + }); + } + @Test public void runVcfExcerptQuery_validQueryNoResults() throws IOException { Query query = new Query(); @@ -118,7 +188,11 @@ public void runVcfExcerptQuery_validQueryNoResults() throws IOException { query.setNumericFilters(Map.of("\\open_access-1000Genomes\\data\\SYNTHETIC_AGE\\", new Filter.DoubleFilter(0.0, 1.0))); String vcfExerpt = variantListProcessor.runVcfExcerptQuery(query, true); - assertEquals("No Variants Found", vcfExerpt); + assertEquals("No Variants Found\n", vcfExerpt); + + } + + public void test() { } diff --git a/service/src/test/java/edu/harvard/hms/dbmi/avillach/hpds/test/VariantMetadataIndexTest.java b/service/src/test/java/edu/harvard/hms/dbmi/avillach/hpds/test/VariantMetadataIndexTest.java index b35ec756..eb746408 100644 --- a/service/src/test/java/edu/harvard/hms/dbmi/avillach/hpds/test/VariantMetadataIndexTest.java +++ b/service/src/test/java/edu/harvard/hms/dbmi/avillach/hpds/test/VariantMetadataIndexTest.java @@ -3,6 +3,7 @@ import java.io.*; import java.util.List; import java.util.Map; +import java.util.Set; import java.util.TreeMap; import java.util.zip.GZIPInputStream; @@ -49,38 +50,38 @@ public static void initializeBinfile() throws Exception { @Test public void findByMultipleVariantSpec_invalidSpec() { List variants = List.of("chr21,5032061,A,G,NOTAGENE,missense_variant"); - Map expectedResult = Map.of(); - Map[] data = new Map[] {vmi.findByMultipleVariantSpec(variants)}; + Map> expectedResult = Map.of(); + Map> data = vmi.findByMultipleVariantSpec(variants); - assertEquals("Wrong number of records in response.", 1, data[0].size()); - assertEquals("The expected values were not found.", new String[]{}, data[0].get("chr21,5032061,A,G,NOTAGENE,missense_variant")); + assertEquals("Wrong number of records in response.", 1, data.size()); + assertEquals("The expected values were not found.", Set.of(), data.get("chr21,5032061,A,G,NOTAGENE,missense_variant")); } @Test public void findByMultipleVariantSpec_validSpec() { List variants = List.of("chr21,5032061,A,G,LOC102723996,missense_variant"); - Map expectedResult = Map.of( + Map> expectedResult = Map.of( "chr21,5032061,A,G,LOC102723996,missense_variant" - , new String[]{"Gene_with_variant=LOC102723996;Variant_severity=MODERATE;Variant_consequence_calculated=missense_variant;Variant_class=SNV;Variant_frequency_in_gnomAD=0.0001346;Variant_frequency_as_text=Rare"}); - Map[] data = new Map[] {vmi.findByMultipleVariantSpec(variants)}; + , Set.of("Gene_with_variant=LOC102723996;Variant_severity=MODERATE;Variant_consequence_calculated=missense_variant;Variant_class=SNV;Variant_frequency_in_gnomAD=0.0001346;Variant_frequency_as_text=Rare")); + Map> data = vmi.findByMultipleVariantSpec(variants); - assertEquals("Wrong number of records in response.", data[0].size(), 1); + assertEquals("Wrong number of records in response.", data.size(), 1); variants.stream().forEach(variant->{ - assertEquals("The expected values were not found.", expectedResult.get(variant), data[0].get(variant)); + assertEquals("The expected values were not found.", expectedResult.get(variant), data.get(variant)); }); } @Test public void findByMultipleVariantSpec_validSpecs() { List variants = List.of("chr21,5032061,A,G,LOC102723996,missense_variant", "chr21,5033914,A,G,LOC102723996,missense_variant"); - Map expectedResult = Map.of( + Map> expectedResult = Map.of( "chr21,5032061,A,G,LOC102723996,missense_variant" - , new String[]{"Gene_with_variant=LOC102723996;Variant_severity=MODERATE;Variant_consequence_calculated=missense_variant;Variant_class=SNV;Variant_frequency_in_gnomAD=0.0001346;Variant_frequency_as_text=Rare"} + , Set.of("Gene_with_variant=LOC102723996;Variant_severity=MODERATE;Variant_consequence_calculated=missense_variant;Variant_class=SNV;Variant_frequency_in_gnomAD=0.0001346;Variant_frequency_as_text=Rare") ,"chr21,5033914,A,G,LOC102723996,missense_variant" - ,new String[]{"Gene_with_variant=LOC102723996;Variant_severity=MODERATE;Variant_consequence_calculated=missense_variant;Variant_class=SNV;Variant_frequency_in_gnomAD=0.0009728;Variant_frequency_as_text=Rare"}); - Map[] data = new Map[] {vmi.findByMultipleVariantSpec(variants)}; + , Set.of("Gene_with_variant=LOC102723996;Variant_severity=MODERATE;Variant_consequence_calculated=missense_variant;Variant_class=SNV;Variant_frequency_in_gnomAD=0.0009728;Variant_frequency_as_text=Rare")); + Map> data = vmi.findByMultipleVariantSpec(variants); - assertEquals("Wrong number of records in response.", data[0].size(), 2); + assertEquals("Wrong number of records in response.", data.size(), 2); variants.stream().forEach(variant->{ - assertEquals("The expected values were not found.", expectedResult.get(variant), data[0].get(variant)); + assertEquals("The expected values were not found.", expectedResult.get(variant), data.get(variant)); }); } @@ -88,42 +89,42 @@ public void findByMultipleVariantSpec_validSpecs() { public void testMultipleVariantSpecSamePOS() { List variants = List.of(spec1, spec4); - Map expectedResult = Map.of( - spec1, new String[]{spec1Info}, - spec4, new String[]{spec4Info}); - Map[] data = new Map[] {vmi.findByMultipleVariantSpec(variants)}; + Map> expectedResult = Map.of( + spec1, Set.of(spec1Info), + spec4, Set.of(spec4Info)); + Map> data = vmi.findByMultipleVariantSpec(variants); - assertEquals("Wrong number of records in response.", data[0].size(), 2); + assertEquals("Wrong number of records in response.", data.size(), 2); variants.stream().forEach(variant->{ - assertEquals("The expected values were not found.", expectedResult.get(variant), data[0].get(variant)); + assertEquals("The expected values were not found.", expectedResult.get(variant), data.get(variant)); }); } @Test public void testMultipleVariantSpecSamePOSAndREF() { List variants = List.of(spec1, spec5); - Map expectedResult = Map.of( - spec1, new String[]{spec1Info}, - spec5, new String[]{spec5Info}); - Map[] data = new Map[] {vmi.findByMultipleVariantSpec(variants)}; + Map> expectedResult = Map.of( + spec1, Set.of(spec1Info), + spec5, Set.of(spec5Info)); + Map> data = vmi.findByMultipleVariantSpec(variants); - assertEquals("Wrong number of records in response.", data[0].size(), 2); + assertEquals("Wrong number of records in response.", data.size(), 2); variants.stream().forEach(variant->{ - assertEquals("The expected values were not found.", expectedResult.get(variant), data[0].get(variant)); + assertEquals("The expected values were not found.", expectedResult.get(variant), data.get(variant)); }); } @Test public void testMultipleVariantSpecSamePOSAndALT() { List variants = List.of(spec1, spec2); - Map expectedResult = Map.of( - spec1, new String[]{spec1Info}, - spec2, new String[]{spec2Info}); - Map[] data = new Map[] {vmi.findByMultipleVariantSpec(variants)}; + Map> expectedResult = Map.of( + spec1, Set.of(spec1Info), + spec2, Set.of(spec2Info)); + Map> data = vmi.findByMultipleVariantSpec(variants); - assertEquals("Wrong number of records in response.", data[0].size(), 2); + assertEquals("Wrong number of records in response.", data.size(), 2); variants.stream().forEach(variant->{ - assertEquals("The expected values were not found.", expectedResult.get(variant), data[0].get(variant)); + assertEquals("The expected values were not found.", expectedResult.get(variant), data.get(variant)); }); } @@ -134,13 +135,13 @@ public void testMultipleVariantSpecSamePOSAndALT() { public void testMultipleVariantSpecSameSpec() { assertThrows(IllegalStateException.class, () -> { List variants = List.of(spec1, spec1); - Map expectedResult = Map.of( - spec1, new String[]{spec1Info}); - Map[] data = new Map[] {vmi.findByMultipleVariantSpec(variants)}; + Map> expectedResult = Map.of( + spec1, Set.of(spec1Info)); + Map> data = vmi.findByMultipleVariantSpec(variants); - assertEquals("Wrong number of records in response.", data[0].size(), 1); + assertEquals("Wrong number of records in response.", data.size(), 1); variants.stream().forEach(variant->{ - assertEquals("The expected values were not found.", expectedResult.get(variant), data[0].get(variant)); + assertEquals("The expected values were not found.", expectedResult.get(variant), data.get(variant)); }); }); } diff --git a/service/src/test/java/edu/harvard/hms/dbmi/avillach/hpds/test/util/BuildIntegrationTestEnvironment.java b/service/src/test/java/edu/harvard/hms/dbmi/avillach/hpds/test/util/BuildIntegrationTestEnvironment.java index 942f03c9..74d6b3fa 100644 --- a/service/src/test/java/edu/harvard/hms/dbmi/avillach/hpds/test/util/BuildIntegrationTestEnvironment.java +++ b/service/src/test/java/edu/harvard/hms/dbmi/avillach/hpds/test/util/BuildIntegrationTestEnvironment.java @@ -19,7 +19,6 @@ public enum BuildIntegrationTestEnvironment { public String binFile = "target/VariantMetadata.javabin"; BuildIntegrationTestEnvironment() { - System.out.println("HELLO WORLD"); try { NewVCFLoader.main(new String[] {VCF_INDEX_FILE, STORAGE_DIR, MERGED_DIR}); CSVLoader.main(new String[] {PHENOTYPIC_DATA_DIRECTORY}); diff --git a/service/src/test/resources/open_access-1000Genomes.chr20.annotated.vcf b/service/src/test/resources/open_access-1000Genomes.chr20.annotated.vcf new file mode 100644 index 00000000..19f1d0ea --- /dev/null +++ b/service/src/test/resources/open_access-1000Genomes.chr20.annotated.vcf @@ -0,0 +1,21 @@ +##fileformat=VCFv4.2 +## NOTE: this is not a real VCF file. It is a copy of chr20 but with no call data +##FORMAT= +##INFO= +##INFO= +##INFO= +##INFO= +##INFO= +##INFO= +#CHROM POS ID REF ALT QUAL FILTER INFO FORMAT HG00096 HG00097 HG00099 HG00100 HG00101 HG00102 HG00103 HG00105 HG00106 HG00107 HG00108 HG00109 HG00110 HG00111 HG00112 HG00113 HG00114 HG00115 HG00116 HG00117 HG00118 HG00119 HG00120 HG00121 HG00122 HG00123 HG00125 HG00126 HG00127 HG00128 HG00129 HG00130 HG00131 HG00132 HG00133 HG00136 HG00137 HG00138 HG00139 HG00140 HG00141 HG00142 HG00143 HG00145 HG00146 HG00148 HG00149 HG00150 HG00151 HG00154 HG00155 HG00157 HG00158 HG00159 HG00160 HG00171 HG00173 HG00174 HG00176 HG00177 HG00178 HG00179 HG00180 HG00181 HG00182 HG00183 HG00185 HG00186 HG00187 HG00188 HG00189 HG00190 HG00231 HG00232 HG00233 HG00234 HG00235 HG00236 HG00237 HG00238 HG00239 HG00240 HG00242 HG00243 HG00244 HG00245 HG00246 HG00250 HG00251 HG00252 HG00253 HG00254 HG00255 HG00256 HG00257 HG00258 HG00259 HG00260 HG00261 HG00262 HG00263 HG00264 HG00265 HG00266 HG00267 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NA20852 NA20853 NA20854 NA20856 NA20858 NA20859 NA20861 NA20862 NA20863 NA20864 NA20866 NA20867 NA20868 NA20869 NA20870 NA20872 NA20874 NA20875 NA20876 NA20877 NA20878 NA20881 NA20882 NA20884 NA20885 NA20886 NA20887 NA20888 NA20889 NA20890 NA20891 NA20892 NA20894 NA20895 NA20896 NA20897 NA20899 NA20900 NA20901 NA20902 NA20903 NA20904 NA20905 NA20906 NA20908 NA20910 NA20911 NA21086 NA21087 NA21088 NA21089 NA21090 NA21091 NA21092 NA21093 NA21094 NA21095 NA21097 NA21098 NA21099 NA21100 NA21101 NA21102 NA21103 NA21104 NA21105 NA21106 NA21107 NA21108 NA21109 NA21110 NA21111 NA21112 NA21113 NA21114 NA21115 NA21116 NA21117 NA21118 NA21119 NA21120 NA21122 NA21123 NA21124 NA21125 NA21126 NA21127 NA21128 NA21129 NA21130 NA21133 NA21135 NA21137 NA21141 NA21142 NA21143 NA21144 +chr20 5032061 20:5032061:A:G A G . . 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NA21137 NA21141 NA21142 NA21143 NA21144 -chr21 5032061 21:5032061:A:G A G . . 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diff --git a/service/src/test/resources/test_vcfIndex.tsv b/service/src/test/resources/test_vcfIndex.tsv index 1636be51..f3182757 100755 --- a/service/src/test/resources/test_vcfIndex.tsv +++ b/service/src/test/resources/test_vcfIndex.tsv @@ -1,3 +1,4 @@ filename chromosome annotated gzip sample_ids patient_ids sample_relationship related_sample_ids src/test/resources/open_access-1000Genomes.chr4.annotated.vcf 4 1 0 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src/test/resources/open_access-1000Genomes.chr21.annotated.vcf 21 1 0 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\ No newline at end of file