diff --git a/src/annotator/config/index.ts b/src/annotator/config/index.ts
index 8ddc75e5c8f..030ec763028 100644
--- a/src/annotator/config/index.ts
+++ b/src/annotator/config/index.ts
@@ -39,6 +39,7 @@ function configurationKeys(context: Context): string[] {
     annotator: [
       'clientUrl',
       'contentInfoBanner',
+      'contentReady',
       'subFrameIdentifier',
       'sideBySide',
     ],
@@ -120,6 +121,11 @@ const configDefinitions: ConfigDefinitionMap = {
     defaultValue: null,
     getValue: getHostPageSetting,
   },
+  contentReady: {
+    allowInBrowserExt: true,
+    defaultValue: null,
+    getValue: getHostPageSetting,
+  },
   enableExperimentalNewNoteButton: {
     allowInBrowserExt: false,
     defaultValue: null,
diff --git a/src/annotator/config/test/index-test.js b/src/annotator/config/test/index-test.js
index f11ba19b3a6..b6432d401bb 100644
--- a/src/annotator/config/test/index-test.js
+++ b/src/annotator/config/test/index-test.js
@@ -81,6 +81,7 @@ describe('annotator/config/index', () => {
             bucketContainerSelector: null,
             clientUrl: 'fakeValue',
             contentInfoBanner: null,
+            contentReady: 'fakeValue',
             enableExperimentalNewNoteButton: null,
             externalContainerSelector: null,
             focus: null,
@@ -116,6 +117,7 @@ describe('annotator/config/index', () => {
             bucketContainerSelector: 'fakeValue',
             clientUrl: 'fakeValue',
             contentInfoBanner: 'fakeValue',
+            contentReady: 'fakeValue',
             enableExperimentalNewNoteButton: 'fakeValue',
             externalContainerSelector: 'fakeValue',
             focus: 'fakeValue',
@@ -175,6 +177,7 @@ describe('annotator/config/index', () => {
         bucketContainerSelector: null,
         clientUrl: null,
         contentInfoBanner: null,
+        contentReady: null,
         enableExperimentalNewNoteButton: null,
         externalContainerSelector: null,
         focus: null,
@@ -233,6 +236,7 @@ describe('annotator/config/index', () => {
         expectedKeys: [
           'clientUrl',
           'contentInfoBanner',
+          'contentReady',
           'subFrameIdentifier',
           'sideBySide',
         ],
diff --git a/src/annotator/guest.ts b/src/annotator/guest.ts
index e7d1b1a6c4f..91b2e9c1e47 100644
--- a/src/annotator/guest.ts
+++ b/src/annotator/guest.ts
@@ -105,6 +105,12 @@ export type GuestConfig = {
   /** Configures a banner or other indicators showing where the content has come from. */
   contentInfoBanner?: ContentInfoConfig;
 
+  /**
+   * Promise that the guest should wait for before it attempts to anchor
+   * annotations.
+   */
+  contentReady?: Promise<void>;
+
   sideBySide?: SideBySideOptions;
 };
 
@@ -191,6 +197,12 @@ export class Guest extends TinyEmitter implements Annotator, Destroyable {
   /** Promise that resolves when feature flags are received from the sidebar. */
   private _featureFlagsReceived: Promise<void>;
 
+  /**
+   * Promise that the guest will wait for before attempting to anchor
+   * annotations.
+   */
+  private _contentReady?: Promise<void>;
+
   private _adder: Adder;
   private _clusterToolbar?: HighlightClusterController;
   private _hostFrame: Window;
@@ -252,6 +264,7 @@ export class Guest extends TinyEmitter implements Annotator, Destroyable {
     super();
 
     this.element = element;
+    this._contentReady = config.contentReady;
     this._hostFrame = hostFrame;
     this._highlightsVisible = false;
     this._isAdderVisible = false;
@@ -603,6 +616,11 @@ export class Guest extends TinyEmitter implements Annotator, Destroyable {
    * re-anchoring the annotation.
    */
   async anchor(annotation: AnnotationData): Promise<Anchor[]> {
+    if (this._contentReady) {
+      await this._contentReady;
+      this._contentReady = undefined;
+    }
+
     /**
      * Resolve an annotation's selectors to a concrete range.
      */
diff --git a/src/annotator/test/guest-test.js b/src/annotator/test/guest-test.js
index 644b80483e7..18b4484c1de 100644
--- a/src/annotator/test/guest-test.js
+++ b/src/annotator/test/guest-test.js
@@ -1336,6 +1336,27 @@ describe('Guest', () => {
 
       assert.lengthOf(guest.anchors, 0);
     });
+
+    it('waits for content to be ready before anchoring', async () => {
+      const events = [];
+      fakeIntegration.anchor = async () => {
+        events.push('fakeIntegration.anchor');
+        return range;
+      };
+      const contentReady = delay(1).then(() => {
+        events.push('contentReady');
+      });
+
+      const guest = createGuest({ contentReady });
+
+      const annotation = {
+        $tag: 'tag1',
+        target: [{ selector: [{ type: 'TextQuoteSelector', exact: 'hello' }] }],
+      };
+      await guest.anchor(annotation);
+
+      assert.deepEqual(events, ['contentReady', 'fakeIntegration.anchor']);
+    });
   });
 
   describe('#detach', () => {