From cf4474b3554c579e6676a43f5e5a3fee460b93a8 Mon Sep 17 00:00:00 2001 From: Alix Pletcher <pletale@ihme.washington.edu> Date: Tue, 28 Jan 2025 11:24:23 -0800 Subject: [PATCH] Update concept model with placeholder values for antibiotics --- .../vivarium_mncnh_portfolio/concept_model.rst | 11 +++++++---- 1 file changed, 7 insertions(+), 4 deletions(-) diff --git a/docs/source/models/concept_models/vivarium_mncnh_portfolio/concept_model.rst b/docs/source/models/concept_models/vivarium_mncnh_portfolio/concept_model.rst index 750fcdfc1..e160937a0 100644 --- a/docs/source/models/concept_models/vivarium_mncnh_portfolio/concept_model.rst +++ b/docs/source/models/concept_models/vivarium_mncnh_portfolio/concept_model.rst @@ -365,11 +365,14 @@ V&V Checks: - Delivery facility type (home, BEmONC, CEmONC) value from intrapartum model - * - 2 - - XX% of each type of facility have antibiotics available - - + - Percentage of each facility type that have antibiotics for neonatal sepsis: 76.8% of CEmONC and 30.2% of BEmONC + - These values are from the 2016 EmONC Final Report and are therefore only reflective of Ethiopian health system a decade ago (we also have data on this + from SARA, via the Health Systems team). Please use these as a placeholder for now while we try to find reliable values for Nigeria and Pakistan. * - 3 - - XX relative risk on mortality from sepsis or other neonatal infections - - It seems like this relative risk will be hard to find in the literature, and we might need to use a sensitivity-analysis approach. + - 0.72 (95% CI 0.64-0.80) relative risk on mortality from sepsis or other neonatal infections + - It seems like this relative risk is hard to find in the literature, and we might need to use a sensitivity-analysis approach. + `This meta-analysis for LiST <https://pmc.ncbi.nlm.nih.gov/articles/PMC3231886/>`_ provides an estimate of the RR of antibiotics on neonatal sepsis, + and we could use their methodology to make our own estimate, or use this one (which is currently a placeholder). * - 4 - XX% of each type of facility have probiotics available - Need to determine who recevied probiotics - all newborns, only LBW, only preterm, etc. ; the coverage is probably zero in current practice, and we will model scenarios where it is nonzero.