Alcohol induced dose dumping (AIDD): Modified-release formulations + alcohol

[davidhedlund]

"This dose dumping effect is an unintended rapid release of large amounts of a given drug, when administered through a modified-release dosage while co-ingesting ethanol.[163] This is considered a pharmaceutical disadvantage due to the high risk of causing drug-induced toxicity by increasing the absorption and serum concentration above the therapeutic window of the drug. The best way to prevent this interaction is by avoiding the co-ingestion of both substances or using specific controlled-release formulations that are resistant to AIDD." - https://en.wikipedia.org/wiki/Alcohol_(drug)#Alcohol_induced_dose_dumping_(AIDD)

"In vitro data suggest some extended-release stimulants dose dump in the presence of alcohol, which is of concern because the ADHD patient population is at risk for alcohol abuse." - https://pubmed.ncbi.nlm.nih.gov/27467139/

Example of extended-release methylphenidate brand: Concerta. See more at https://en.wikipedia.org/w/index.php?title=Methylphenidate&oldid=1218835159#Extended-release

I started https://psychonautwiki.org/wiki/Template:Warning/Alcohol_induced_dose_dumping_(AIDD)

[isaakhanimann]

Detailed substance data is a concern of PsychonautWiki, not the Journal app. The app just shows some key data that is accessible through the bifrost PW API. So for this example please just make sure that you annotate the interaction between Alcohol and other substances correctly in PW such that app users can see that there is some interaction. If they want more info on it they can open the corresponding article in PW, I'm not going to add these explanations in the app.

[davidhedlund]

Detailed substance data is a concern of PsychonautWiki, not the Journal app. The app just shows some key data that is accessible through the bifrost PW API. So for this example please just make sure that you annotate the interaction between Alcohol and other substances correctly in PW such that app users can see that there is some interaction. If they want more info on it they can open the corresponding article in PW, I'm not going to add these explanations in the app.

My suggestion was intended to include modified-release formulations, not just extended release methylphenidate. Also, alcohol is one of the most consumed drugs in the world, so I think this particular issue could help a significant number of user to prevent overdoses.

So a "modified-release formulation" checkbox in the app for any substance would be useful. It can be hidden by default.

But if you think it's too much work, then I respect if you want to close it.

[isaakhanimann]

I've been wanting to add different forms of the same substance, such as extended release formulations. But PW doesn't have that data in the API and I don't want the responsibility and work of maintaining a database such as PW.

[davidhedlund]

I've been wanting to add different forms of the same substance, such as extended release formulations. But PW doesn't have that data in the API and I don't want the responsibility and work of maintaining a database such as PW.

Perhaps you can create a "PW data required"-ish label, and add that label to this issue?