diff --git a/cookie_consent/migrations/0004_cookie_natural_key.py b/cookie_consent/migrations/0004_cookie_natural_key.py
new file mode 100644
index 0000000..6dfa54a
--- /dev/null
+++ b/cookie_consent/migrations/0004_cookie_natural_key.py
@@ -0,0 +1,19 @@
+# Generated by Django 4.2.13 on 2024-05-09 20:22
+
+from django.db import migrations, models
+
+
+class Migration(migrations.Migration):
+
+    dependencies = [
+        ("cookie_consent", "0003_alter_cookiegroup_varname"),
+    ]
+
+    operations = [
+        migrations.AddConstraint(
+            model_name="cookie",
+            constraint=models.UniqueConstraint(
+                fields=("cookiegroup", "name", "domain"), name="natural_key"
+            ),
+        ),
+    ]
diff --git a/cookie_consent/models.py b/cookie_consent/models.py
index 7fe0d85..c9a66ba 100644
--- a/cookie_consent/models.py
+++ b/cookie_consent/models.py
@@ -48,6 +48,11 @@ def update(self, **kwargs):
         return super().update(**kwargs)
 
 
+class CookieGroupManager(models.Manager.from_queryset(BaseQueryset)):
+    def get_by_natural_key(self, varname):
+        return self.get(varname=varname)
+
+
 class CookieGroup(models.Model):
     varname = models.CharField(
         _("Variable name"),
@@ -70,7 +75,7 @@ class CookieGroup(models.Model):
     ordering = models.IntegerField(_("Ordering"), default=0)
     created = models.DateTimeField(_("Created"), auto_now_add=True, blank=True)
 
-    objects = BaseQueryset.as_manager()
+    objects = CookieGroupManager()
 
     class Meta:
         verbose_name = _("Cookie Group")
@@ -88,6 +93,9 @@ def save(self, *args, **kwargs):
     def delete(self, *args, **kwargs):
         return super().delete(*args, **kwargs)
 
+    def natural_key(self):
+        return (self.varname,)
+
     def get_version(self) -> str:
         try:
             return str(self.cookie_set.all()[0].get_version())
@@ -104,6 +112,12 @@ def for_json(self) -> CookieGroupDict:
         }
 
 
+class CookieManager(models.Manager.from_queryset(BaseQueryset)):
+    def get_by_natural_key(self, name, domain, cookiegroup):
+        group = CookieGroup.objects.get_by_natural_key(cookiegroup)
+        return self.get(cookiegroup=group, name=name, domain=domain)
+
+
 class Cookie(models.Model):
     cookiegroup = models.ForeignKey(
         CookieGroup,
@@ -116,11 +130,17 @@ class Cookie(models.Model):
     domain = models.CharField(_("Domain"), max_length=250, blank=True)
     created = models.DateTimeField(_("Created"), auto_now_add=True, blank=True)
 
-    objects = BaseQueryset.as_manager()
+    objects = CookieManager()
 
     class Meta:
         verbose_name = _("Cookie")
         verbose_name_plural = _("Cookies")
+        constraints = [
+            models.UniqueConstraint(
+                fields=("cookiegroup", "name", "domain"),
+                name="natural_key",
+            ),
+        ]
         ordering = ["-created"]
 
     def __str__(self):
@@ -134,6 +154,11 @@ def save(self, *args, **kwargs):
     def delete(self, *args, **kwargs):
         return super().delete(*args, **kwargs)
 
+    def natural_key(self):
+        return (self.name, self.domain) + self.cookiegroup.natural_key()
+
+    natural_key.dependencies = ["cookie_consent.cookiegroup"]
+
     @property
     def varname(self):
         return "%s=%s:%s" % (self.cookiegroup.varname, self.name, self.domain)
diff --git a/docs/changelog.rst b/docs/changelog.rst
index ad28241..a5dd5f9 100644
--- a/docs/changelog.rst
+++ b/docs/changelog.rst
@@ -6,8 +6,9 @@ Changelog
 ------------------
 
 💥 This feature release has a potential breaking change. The ``CookieGroup.varname``
-field now has a unique constraint on it. If you have duplicate values, this migration
-will crash.
+field now has a unique constraint on it. The ``Cookie`` model now has a unique
+constraint on ``cookiegroup``, ``name`` and ``domain``. If you have duplicate values,
+this migration will crash.
 
 * ...
 
diff --git a/tests/test_cookie_group_model.py b/tests/test_cookie_group_model.py
new file mode 100644
index 0000000..0a979bc
--- /dev/null
+++ b/tests/test_cookie_group_model.py
@@ -0,0 +1,19 @@
+import pytest
+
+from cookie_consent.models import CookieGroup
+
+
+def test_natural_key():
+    group = CookieGroup(varname="social")
+
+    assert group.natural_key() == ("social",)
+
+
+@pytest.mark.django_db
+def test_load_by_natural_key():
+    social_group = CookieGroup.objects.create(varname="social")
+    CookieGroup.objects.create(varname="other")
+
+    loaded_group = CookieGroup.objects.get_by_natural_key("social")
+
+    assert loaded_group == social_group
diff --git a/tests/test_cookie_model.py b/tests/test_cookie_model.py
new file mode 100644
index 0000000..58111a5
--- /dev/null
+++ b/tests/test_cookie_model.py
@@ -0,0 +1,24 @@
+import pytest
+
+from cookie_consent.models import Cookie, CookieGroup
+
+
+def test_natural_key():
+    cookie = Cookie(
+        cookiegroup=CookieGroup(varname="analytics"), name="trck", domain="example.com"
+    )
+
+    assert cookie.natural_key() == ("trck", "example.com", "analytics")
+
+
+@pytest.mark.django_db
+def test_load_by_natural_key():
+    social_group = CookieGroup.objects.create(varname="social")
+    cookie = Cookie.objects.create(
+        cookiegroup=social_group, name="trck", domain="example.com"
+    )
+    Cookie.objects.create(cookiegroup=social_group, name="other", domain="example.com")
+
+    loaded_cookie = Cookie.objects.get_by_natural_key("trck", "example.com", "social")
+
+    assert loaded_cookie == cookie
diff --git a/tests/test_models.py b/tests/test_models.py
index 96afc79..5e51c1d 100644
--- a/tests/test_models.py
+++ b/tests/test_models.py
@@ -1,6 +1,5 @@
 # -*- coding: utf-8 -*-
 from copy import deepcopy
-from unittest import mock
 
 from django.conf import settings
 from django.core.cache import caches