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drug_targets.txt
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drug_targets.txt
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Drug Target Drug Name
ABL WH-4-023,Nilotinib,Imatinib,Dasatinib,Bosutinib,AP-24534
ABL1 VX-680,AZD-0530
AKT1 MK-2206,AKTinhibitorVIII,A-443654
AKT2 MK-2206,AKTinhibitorVIII,A-443654
AKT3 A-443654
ALK PF-02341066,NVP-TAE684
AMPKagonist Metformin,AICAR,A-769662
ARFGAP QS11
ATM KU-55933
ATPase Thapsigargin
AURKB ZM-447439,SL0101-1,BX-795,BI-D1870
AURKC BX-795
Androgenreceptor(ANDR) Bicalutamide
AuroraA VX-680
AuroraB VX-680
AuroraC VX-680
BCL-2 TW37,ObatoclaxMesylate
BCL-W ABT-263
BCL-XL TW37,ObatoclaxMesylate,ABT-263
BCL2 ABT-263
BCR-ABL GNF-2
BMX WZ-1-84
BRAF SB590885,PLX4720,AZ628
BTK LFM-A13
CASP3activator PAC-1
CDK1 RO-3306,CGP-60474
CDK2 CGP-60474
CDK4 PD-0332991,CGP-082996
CDK5 CGP-60474
CDK6 PD-0332991
CDK7 CGP-60474
CDK9 CGP-60474
CDKs Roscovitine
CHK1 AZD7762,681640
CHK2 AZD7762
Ca++transporting Thapsigargin
DNAPK NU-7441
DNAcrosslinker MitomycinC,Cisplatin
DNAdamage Bleomycin
DNAintercalating Doxorubicin
DNAreplication Gemcitabine
DNAsynthesis Cytarabine
Dihydrofolatereductase(DHFR) Pyrimethamine,Methotrexate
EGFR Lapatinib,Gefitinib,Erlotinib,BIBW2992
ERBB2 Lapatinib,BIBW2992
ERK5(MK07) XMD8-85
FAK PF-562271
FGFR1 PD-173074
FGFR3 PD-173074
FLT3 VX-680,Sunitinib,Sorafenib,CEP-701
Farnesyl-transferase(FNTA) Tipifarnib
Farnesyltransferase(FNTA) FTI-277
GADD34-PP1Cphosphatase Salubrinal
GSK3A SB216763
GSK3B SB216763,CHIR-99021
HDAC MS-275
HDACinhibitorClassI Vorinostat
HSP70 Elesclomol
HSP90 CCT018159,AUY922,17-AAG
IGF1R OSI-906,BMS-754807,BMS-536924
IIa Vorinostat
IIb Vorinostat
IKK BX-795
IKKE KIN001-135
ITK BMS-509744
IV Vorinostat
JAK2 VX-680,CEP-701
JNK JNK-9L,JNKInhibitorVIII,AS601245
JNK2 BIRB0796
KDR Sunitinib,Sorafenib
KIF11 S-Trityl-L-cysteine
KIT Sunitinib,Sorafenib,Pazopanib,Midostaurin,Imatinib,Dasatinib,Axitinib
MCL-1 ObatoclaxMesylate
MDM2 Nutlin-3a,JNJ-26854165
MEK1 RDEA119,PD-0325901,CI-1040,AZD6244
MEK2 RDEA119,PD-0325901,CI-1040,AZD6244
MET PHA-665752,PF-02341066
MTOR Temsirolimus,Rapamycin,JW-7-52-1
Microtubules Vinorelbine,Vinblastine,Paclitaxel,EpothiloneB,Docetaxel
NFKB1 Parthenolide
NTRK1 GW441756,CEP-701
PAK IPA-3
PARP1 AZD-2281,AG-014699,ABT-888
PARP2 AZD-2281,AG-014699,ABT-888
PDGFR Imatinib,Dasatinib,Axitinib,AMG-706
PDGFRA Sunitinib,Sorafenib,Pazopanib
PDGFRB Sunitinib,Sorafenib,Pazopanib
PDK1 BX-795
PI3K(Class1)andmTORC1 NVP-BEZ235
PI3K(Class1)andmTORC2 NVP-BEZ235
PI3K(class1) GDC0941
PI3Kb WO2009093972
PI3Kb(P3C2B) AZD6482
PIM3 SL0101-1
PLK1 GW843682X,BI-D1870,BI-2536
PLK2 BI-2536
PLK3 BI-2536
PPM1D CCT007093
PRKC Bryostatin1
Prolyl-4-Hydroxylase DMOG
Proteasome MG-132,Bortezomib
RET CEP-701,AMG-706
ROCK GSK269962A
RSK SL0101-1,CMK
RSK1 BI-D1870
RSK2 BI-D1870
RSK3 BI-D1870
RSK5 BI-D1870
RacGTPases EHT1864
RetinioicacidXfamilyagonist Bexarotene
RetinoicacidandretinoidXreceptoragonist ATRA
SGK3 GSK-650394
SHP1 NSC-87877
SHP11) NSC-87877
SHP2(PTN6 NSC-87877
SMO GDC-0449,Cyclopamine
SRC Dasatinib,Bosutinib,AZD-0530
SRCfamily WH-4-023,A-770041
SYK BAY61-3606
TBK1 BX-795
TEC Bosutinib
TNFalpha Lenalidomide
TOP1 Camptothecin
TOP2 Etoposide
Targets Drug Name
VEGFR Pazopanib,Axitinib,AMG-706
WEE1 681640
XIAP Embelin
c-KIT AMG-706
cardiacmuscle Thapsigargin
g-secretase Z-LLNle-CHO
gamma-secretase BMS-708163
mTORC1 AZD8055
mTORC2 AZD8055
p38 VX-702,BIRB0796
p70S6KA PF-4708671
slowtwitch2 Thapsigargin
unknown Shikonin,FH535