diff --git a/streamlit_pdf_viewer/__init__.py b/streamlit_pdf_viewer/__init__.py
index 886be9e..54fff1a 100644
--- a/streamlit_pdf_viewer/__init__.py
+++ b/streamlit_pdf_viewer/__init__.py
@@ -1,7 +1,7 @@
 import base64
 import os
 from pathlib import Path
-from typing import Union, List, Optional
+from typing import Union, List, Optional, Callable
 
 import streamlit.components.v1 as components
 import json
@@ -39,7 +39,8 @@ def pdf_viewer(
         resolution_boost: int = 1,
         scroll_to_page: int = None,
         scroll_to_annotation: int = None,
-):
+        on_annotation_click: Optional[Callable[[dict], None]] = None,
+    ):
     """
     pdf_viewer function to display a PDF file in a Streamlit app.
 
@@ -59,6 +60,7 @@ def pdf_viewer(
     :param resolution_boost: Boost the resolution by a factor from 2 to 10. Defaults to 1.
     :param scroll_to_page: Scroll to a specific page in the PDF. The parameter is an integer, which represent the positional value of the page. E.g. 1, will be the first page. Defaults to None.
     :param scroll_to_annotation: Scroll to a specific annotation in the PDF. The parameter is an integer, which represent the positional value of the annotation. E.g. 1, will be the first annotation. Defaults to None.
+    :param on_annotation_click: A callback function that will be called when an annotation is clicked. The function should accept a single argument, which is the annotation that was clicked. Defaults to None.
 
     The function reads the PDF file (from a file path, URL, or binary data), encodes it in base64,
     and uses a Streamlit component to render it in the app. It supports optional annotations and adjustable margins.
@@ -118,6 +120,12 @@ def pdf_viewer(
         scroll_to_page=scroll_to_page,
         scroll_to_annotation=scroll_to_annotation
     )
+
+    # Execute the custom callback function
+    if component_value and 'clicked_annotation' in component_value:
+        clicked_annotation = component_value['clicked_annotation']
+        if on_annotation_click is not None and callable(on_annotation_click):
+            on_annotation_click(clicked_annotation)
     return component_value
 
 
diff --git a/streamlit_pdf_viewer/frontend/src/PdfViewer.vue b/streamlit_pdf_viewer/frontend/src/PdfViewer.vue
index 4881016..9900b38 100644
--- a/streamlit_pdf_viewer/frontend/src/PdfViewer.vue
+++ b/streamlit_pdf_viewer/frontend/src/PdfViewer.vue
@@ -2,12 +2,20 @@
   <div id="pdfContainer" :style="pdfContainerStyle">
     <div v-if="args.rendering==='unwrap'">
       <div id="pdfViewer" :style="pdfViewerStyle">
-      <div id="pdfAnnotations" v-if="args.annotations">
-        <div v-for="(annotation, index) in filteredAnnotations" :key="index" :style="getPageStyle">
-          <div :style="getAnnotationStyle(annotation, index)" :id="`annotation-${index}`"></div>
+        <div id="pdfAnnotations" v-if="args.annotations">
+          <div
+              v-for="(annotation, index) in filteredAnnotations"
+              :key="index"
+              :style="getPageStyle"
+              @click="handleAnnotationClick(annotation, index)"
+          >
+            <div
+                :style="getAnnotationStyle(annotation, index)"
+                :id="`annotation-${index}`"
+            ></div>
+          </div>
         </div>
       </div>
-      </div>
     </div>
     <div v-else-if="args.rendering==='legacy_embed'">
       <embed :src="`data:application/pdf;base64,${args.binary}`" :width="`${args.width}`" :height="`${args.height}`" type="application/pdf"/>
@@ -55,6 +63,16 @@ export default {
       })
     });
 
+    const handleAnnotationClick = (annotation, index) => {
+      // Convert the Proxy object to a plain object
+      const serializedAnnotation = JSON.parse(JSON.stringify(annotation));
+
+      // Send data to Streamlit
+      Streamlit.setComponentValue({
+        clicked_annotation: { index, ...serializedAnnotation },
+      });
+    };
+
     const renderText = props.args.render_text === true
 
     const pdfContainerStyle = computed(() => ({
@@ -355,6 +373,7 @@ export default {
 
     return {
       filteredAnnotations,
+      handleAnnotationClick,
       getAnnotationStyle,
       pdfContainerStyle,
       pdfViewerStyle,