Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

Is it possible to compute MSAs? #1

Open
rubenalv opened this issue Aug 16, 2024 · 0 comments
Open

Is it possible to compute MSAs? #1

rubenalv opened this issue Aug 16, 2024 · 0 comments

Comments

@rubenalv
Copy link

Is it possible to compute multiple sequence alignments, or is the available software limited to pairwise ones?
I confess myself naive in the field... could anyone provide a hint as to how to use the alignment scores to cluster sequences by similarity?

P.S. Are you planning on updating your SPRINT to use embeddings? Incorporating context could give a twist to PPI prediction, perhaps allowing a better use of homologue PPIs in different organisms where sequence similarity is low (thinking of the way SPRINT uses seeds) but aminoacid properties are similar (exploiting a more powerful alignment strategy with the embeddings)?

Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Labels
None yet
Projects
None yet
Development

No branches or pull requests

1 participant