diff --git a/packaging/apple/mac_packager.sh.in b/packaging/apple/mac_packager.sh.in
index dd3519b7f0..2e693c6dc1 100755
--- a/packaging/apple/mac_packager.sh.in
+++ b/packaging/apple/mac_packager.sh.in
@@ -33,6 +33,10 @@ done
 
 @dtk_DIR@/bin/dtkDeploy medInria.app $injectDirs &>/dev/null
 
+@CMAKE_COMMAND@ --install @pyncpp_ROOT@ --prefix . --component Runtime
+mkdir medInria.app/Contents/Resources/lib
+mv lib/python@PYTHON_VERSION_MAJOR@.@PYTHON_VERSION_MINOR@ medInria.app/Contents/Resources/lib
+
 #Run fancy packaging apple script
 
 \cp -f @medInria_SOURCE_DIR@/utils/osx_packaging/BaseMedinriaPackage.sparseimage.gz @PROJECT_BINARY_DIR@/MedinriaPackage.sparseimage.gz
diff --git a/packaging/linux/LinuxPackaging.cmake b/packaging/linux/LinuxPackaging.cmake
index 7d70129e92..89866a0533 100644
--- a/packaging/linux/LinuxPackaging.cmake
+++ b/packaging/linux/LinuxPackaging.cmake
@@ -84,11 +84,16 @@ set(backup_CPACK_INSTALL_CMAKE_PROJECTS ${CPACK_INSTALL_CMAKE_PROJECTS} ${CMAKE_
 
 #clear it
 set(CPACK_INSTALL_CMAKE_PROJECTS "")
-foreach(external_project ${external_projects}) 
-	if(NOT USE_SYSTEM_${external_project} AND BUILD_SHARED_LIBS_${external_project})
-		ExternalProject_Get_Property(${external_project} binary_dir)
-		set(CPACK_INSTALL_CMAKE_PROJECTS ${CPACK_INSTALL_CMAKE_PROJECTS} ${binary_dir} ${external_project} ALL "/")
-	endif()
+foreach(external_project ${external_projects})
+    if(NOT USE_SYSTEM_${external_project}
+            AND BUILD_SHARED_LIBS_${external_project}
+            AND DEFINED ${external_project}_ROOT)
+        install(CODE "
+            execute_process(
+                COMMAND ${CMAKE_COMMAND} --install ${${external_project}_ROOT} --prefix \"\${CMAKE_INSTALL_PREFIX}\"
+                )
+            ")
+    endif()
 endforeach()
 
 foreach(dir ${PRIVATE_PLUGINS_DIRS})
diff --git a/packaging/windows/WindowsPackaging.cmake b/packaging/windows/WindowsPackaging.cmake
index 9e36e36b86..2adca34c39 100644
--- a/packaging/windows/WindowsPackaging.cmake
+++ b/packaging/windows/WindowsPackaging.cmake
@@ -117,6 +117,9 @@ list(APPEND
   ${DCMTK_ROOT}/bin/${CONFIG_MODE}
   )
 
+
+install(CODE "execute_process(COMMAND ${CMAKE_COMMAND} --install ${pyncpp_ROOT} --prefix \"\${CMAKE_INSTALL_PREFIX}\" --component Runtime)" COMPONENT Runtime)
+
 install(CODE "
 
 file(GLOB_RECURSE itk_files LIST_DIRECTORIES true \"${ITK_ROOT}/bin/*.dll\")
@@ -139,6 +142,7 @@ endforeach()
 
 file(INSTALL ${MEDINRIA_FILES}/                         DESTINATION \${CMAKE_INSTALL_PREFIX}/bin/              FILES_MATCHING PATTERN \"*${CMAKE_EXECUTABLE_SUFFIX}\")
 file(INSTALL ${MEDINRIA_FILES}/                         DESTINATION \${CMAKE_INSTALL_PREFIX}/bin/              FILES_MATCHING PATTERN \"*${CMAKE_SHARED_LIBRARY_SUFFIX}\")
+file(INSTALL ${MEDINRIA_FILES}/                         DESTINATION \${CMAKE_INSTALL_PREFIX}/bin/              FILES_MATCHING PATTERN \"*.pyd\")
 file(INSTALL ${QT_PLUGINS_DIR}/imageformats/qgif.dll    DESTINATION \${CMAKE_INSTALL_PREFIX}/bin/imageformats/ FILES_MATCHING PATTERN \"*${CMAKE_SHARED_LIBRARY_SUFFIX}\")
 file(INSTALL ${QT_PLUGINS_DIR}/imageformats/qicns.dll   DESTINATION \${CMAKE_INSTALL_PREFIX}/bin/imageformats/ FILES_MATCHING PATTERN \"*${CMAKE_SHARED_LIBRARY_SUFFIX}\")
 file(INSTALL ${QT_PLUGINS_DIR}/imageformats/qico.dll    DESTINATION \${CMAKE_INSTALL_PREFIX}/bin/imageformats/ FILES_MATCHING PATTERN \"*${CMAKE_SHARED_LIBRARY_SUFFIX}\")
@@ -206,4 +210,4 @@ if(${SDK_PACKAGING} )
     else()
         message("No folder  ${SDK_DIR} exists. SDK will not be installed.")
     endif()
-endif()
\ No newline at end of file
+endif()
diff --git a/src/CMakeLists.txt b/src/CMakeLists.txt
index 1ce34e993c..1e8975d001 100644
--- a/src/CMakeLists.txt
+++ b/src/CMakeLists.txt
@@ -83,6 +83,11 @@ option(USE_FFmpeg
   )
 endif()
 
+option(USE_Python
+  "Build with Python support"
+  ON
+  )
+
 ## #############################################################################
 ## Find package
 ## #############################################################################
@@ -103,6 +108,10 @@ find_package(Qt${QT_VERSION_MAJOR} REQUIRED COMPONENTS
 
 find_package(dtk REQUIRED)
 
+if(USE_Python)
+    find_package(pyncpp REQUIRED COMPONENTS CPP_API Qt5)
+endif()
+
 ## #############################################################################
 ## enable c++ 17
 ## #############################################################################
diff --git a/src/app/medInria/CMakeLists.txt b/src/app/medInria/CMakeLists.txt
index 45586eec24..5ab8006572 100644
--- a/src/app/medInria/CMakeLists.txt
+++ b/src/app/medInria/CMakeLists.txt
@@ -141,6 +141,41 @@ target_link_libraries(${TARGET_NAME} PRIVATE
   med::CoreGui
   )
 
+## #############################################################################
+## Python
+## #############################################################################
+
+if(USE_Python)
+    target_link_libraries(${TARGET_NAME} PUBLIC ${pyncpp_CPP_API_LIBRARY})
+
+    if(APPLE)
+        set(python_home "../Resources")
+    else()
+        set(python_home "..")
+    endif()
+
+    set(python_home "${python_home}/${pyncpp_PYTHON_INSTALL_DESTINATION}")
+
+    if(APPLE)
+        set(python_plugin_path "../Plugins/python")
+    else()
+        set(python_plugin_path "python_plugins")
+    endif()
+
+    target_compile_definitions(${TARGET_NAME} PUBLIC
+        USE_PYTHON
+        PYTHON_HOME="${python_home}"
+        PYTHON_PLUGIN_PATH="${python_plugin_path}"
+        BUILD_PYTHON_HOME="${pyncpp_PYTHON_DIR}"
+        BUILD_PYTHON_PLUGIN_PATH="${CMAKE_BINARY_DIR}/bin/python_plugins"
+        )
+
+    if(WIN32)
+        target_compile_definitions(${TARGET_NAME} PUBLIC
+            PLUGINS_LEGACY_PATH="plugins_legacy"
+            )
+    endif()
+endif()
 
 ## #############################################################################
 ## install
diff --git a/src/app/medInria/main.cpp b/src/app/medInria/main.cpp
index f7f432fa81..b5619e761b 100644
--- a/src/app/medInria/main.cpp
+++ b/src/app/medInria/main.cpp
@@ -43,6 +43,10 @@
 
 #include<medFirstStart.h>
 
+#ifdef USE_PYTHON
+#include <pyncpp.h>
+#endif
+
 void forceShow(medMainWindow &mainwindow)
 {
     // Idea and code taken from the OpenCOR project, Thanks Allan for the code!
@@ -181,6 +185,89 @@ int main(int argc, char *argv[])
     if (runningMedInria)
         return 0;
 
+#ifdef USE_PYTHON
+    pyncpp::Manager pythonManager;
+    QString pythonHomePath = PYTHON_HOME;
+    QDir applicationPath = qApp->applicationDirPath();
+    QDir pythonHome = applicationPath;
+    QDir pythonPluginPath = pythonHome;
+    bool pythonHomeFound = false;
+    bool pythonPluginsFound = false;
+    QString pythonErrorMessage;
+
+    if (pythonHome.cd(PYTHON_HOME))
+    {
+        pythonHomeFound = true;
+        pythonPluginsFound = pythonPluginPath.cd(PYTHON_PLUGIN_PATH);
+    }
+    else
+    {
+        if (pythonHome.cd(BUILD_PYTHON_HOME))
+        {
+            pythonHomeFound = true;
+            pythonPluginsFound = pythonPluginPath.cd(BUILD_PYTHON_PLUGIN_PATH);
+        }
+    }
+
+    if (!pythonHomeFound)
+    {
+        pythonErrorMessage = "The embedded Python could not be found ";
+    }
+    else
+    {
+        if(!pythonManager.initialize(qUtf8Printable(pythonHome.absolutePath())))
+        {
+            pythonErrorMessage = "Initialization of the embedded Python failed.";
+        }
+        else
+        {
+            if (pythonPluginsFound)
+            {
+                try
+                {
+                    pyncpp::Module sysModule = pyncpp::Module::import("sys");
+                    pyncpp::Object sysPath = sysModule.attribute("path");
+                    sysPath.append(pyncpp::Object(pythonPluginPath.absolutePath()));
+                    qInfo() << "Added Python plugin path: " << pythonPluginPath.path();
+
+#ifdef Q_OS_WIN
+                    QDir sitePackages = pythonHome;
+
+                    if (sitePackages.cd("lib/site-packages"))
+                    {
+                        sysPath.append(pyncpp::Object(sitePackages.absolutePath()));
+                    }
+                    else
+                    {
+                        pythonErrorMessage = "Cannot find site directory.";
+                    }
+
+                    pyncpp::Module osModule = pyncpp::Module::import("os");
+                    osModule.callMethod("add_dll_directory", applicationPath.absolutePath());
+                    qInfo() << "Added Python DLL path: " << applicationPath.path();
+
+                    QDir pluginsLegacyPath = applicationPath;
+
+                    if (pluginsLegacyPath.cd(PLUGINS_LEGACY_PATH))
+                    {
+                        osModule.callMethod("add_dll_directory", pluginsLegacyPath.absolutePath());
+                        qInfo() << "Added Python DLL path: " << pluginsLegacyPath.path();
+                    }
+                    else
+                    {
+                        pythonErrorMessage = "Could not find legacy plugins path.";
+                    }
+#endif // Q_OS_WIN
+                }
+                catch (pyncpp::Exception& e)
+                {
+                    pythonErrorMessage = e.what();
+                }
+            }
+        }
+    }
+#endif // USE_PYTHON
+
     QNetworkAccessManager  *qnam = new QNetworkAccessManager(&application);
     medFirstStart firstStart(qnam);
     firstStart.pushPathToCheck(medSourcesLoader::path(), ":/configs/DataSourcesDefault.json", "dataSourceLoader", "", medSourcesLoader::initSourceLoaderCfg);
@@ -291,6 +378,14 @@ int main(int argc, char *argv[])
         QGLFormat::setDefaultFormat(format);
     }
 
+#ifdef USE_PYTHON
+    if(!pythonErrorMessage.isEmpty())
+    {
+        qWarning() << "(Python error) " << pythonErrorMessage;
+        QMessageBox::warning(mainwindow, "Python error", pythonErrorMessage);
+    }
+#endif
+
     if (medPluginManager::instance()->plugins().isEmpty())
     {
         QMessageBox::warning(
diff --git a/superbuild/CMakeLists.txt b/superbuild/CMakeLists.txt
index d2be24f338..2e69628d86 100644
--- a/superbuild/CMakeLists.txt
+++ b/superbuild/CMakeLists.txt
@@ -11,6 +11,8 @@
 #
 ################################################################################
 
+option(USE_Python "Build with Python support" ON)
+
 ## #############################################################################
 ## Add packages
 ## #############################################################################
@@ -28,6 +30,16 @@ find_package(Qt${QT_VERSION_MAJOR} REQUIRED COMPONENTS
   Quick
   )
 
+if (USE_Python AND UNIX)
+    if(APPLE)
+        set(default_root_dir "/usr/local/opt/openssl")
+    else()
+        set(default_root_dir)
+    endif()
+    set(OPENSSL_ROOT_DIR ${default_root_dir} CACHE PATH "Root directory of OpenSSL.")
+    find_package(OpenSSL COMPONENTS SSL)
+endif()
+
 ## #############################################################################
 ## Add exteral projects
 ## #############################################################################
@@ -71,6 +83,12 @@ if (USE_DTKIMAGING)
         )
 endif()
 
+if (USE_Python)
+    list(APPEND external_projects
+        pyncpp
+        )
+endif()
+
 list(APPEND external_projects
     medInria
     )
diff --git a/superbuild/projects_modules/medInria.cmake b/superbuild/projects_modules/medInria.cmake
index 301bba9728..ab96978a62 100644
--- a/superbuild/projects_modules/medInria.cmake
+++ b/superbuild/projects_modules/medInria.cmake
@@ -33,6 +33,12 @@ if (USE_DTKIMAGING)
        dtkImaging
        )
 endif()
+
+if (USE_Python)
+  list(APPEND ${ep}_dependencies
+      pyncpp
+      )
+endif()
   
 ## #############################################################################
 ## Prepare the project
@@ -107,6 +113,12 @@ if (USE_DTKIMAGING)
     -DdtkImaging_DIR:PATH=${dtkImaging_DIR}
     )
 endif()
+
+if (USE_Python)
+  list(APPEND cmake_cache_args
+      -Dpyncpp_ROOT:PATH=${pyncpp_ROOT}
+      )
+endif()
   
 ## #############################################################################
 ## Add external-project
diff --git a/superbuild/projects_modules/pyncpp.cmake b/superbuild/projects_modules/pyncpp.cmake
new file mode 100644
index 0000000000..32a5f0be41
--- /dev/null
+++ b/superbuild/projects_modules/pyncpp.cmake
@@ -0,0 +1,78 @@
+################################################################################
+#
+# medInria
+#
+# Copyright (c) INRIA 2024. All rights reserved.
+# See LICENSE.txt for details.
+#
+#  This software is distributed WITHOUT ANY WARRANTY; without even
+#  the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR
+#  PURPOSE.
+#
+################################################################################
+
+set(PYTHON_VERSION_MAJOR 3 CACHE STRING "Python major version")
+set(PYTHON_VERSION_MINOR 10 CACHE STRING "Python minor version")
+set(PYTHON_VERSION_PATCH 10 CACHE STRING "Python patch version")
+
+function(pyncpp_project)
+
+    set(ep pyncpp)
+
+    EP_Initialisation(${ep}
+        USE_SYSTEM OFF
+        BUILD_SHARED_LIBS ON
+        REQUIRED_FOR_PLUGINS ON
+        )
+
+    if(NOT USE_SYSTEM_${ep})
+
+        epComputPath(${ep})
+
+        set(project_args
+            GIT_REPOSITORY ${GITHUB_PREFIX}LIRYC-IHU/pyncpp.git
+            GIT_TAG 0.1.x
+            GIT_SHALLOW True
+            GIT_PROGRESS True
+            )
+
+        set(cmake_args
+            ${ep_common_cache_args}
+            -D "PYNCPP_PYTHON_VERSION_MAJOR:STRING=${PYTHON_VERSION_MAJOR}"
+            -D "PYNCPP_PYTHON_VERSION_MINOR:STRING=${PYTHON_VERSION_MINOR}"
+            -D "PYNCPP_PYTHON_VERSION_PATCH:STRING=${PYTHON_VERSION_PATCH}"
+            -D "CMAKE_BUILD_TYPE=${CMAKE_BUILD_TYPE_ExtProjs}"
+            )
+
+        if(UNIX)
+            list(APPEND cmake_args
+                -D Qt5_DIR:PATH=${Qt5_DIR}
+                -D OPENSSL_ROOT_DIR:PATH=${OPENSSL_ROOT_DIR}
+                )
+        endif()
+
+        ## #####################################################################
+        ## Add external project
+        ## #####################################################################
+
+        ExternalProject_Add(${ep}
+            PREFIX ${EP_PATH_SOURCE}
+            SOURCE_DIR ${EP_PATH_SOURCE}/${ep}
+            BINARY_DIR ${build_path}
+            TMP_DIR ${tmp_path}
+            STAMP_DIR ${stamp_path}
+            DEPENDS ${${ep}_dependencies}
+            CMAKE_ARGS ${cmake_args}
+            INSTALL_COMMAND ""
+            "${project_args}"
+            )
+
+        ## #####################################################################
+        ## Export variables
+        ## #####################################################################
+
+        set(${ep}_ROOT "${build_path}" PARENT_SCOPE)
+
+    endif()
+
+endfunction()