diff --git a/change/react-native-windows-908658ce-9dd6-444b-9d6b-b49cd12b2bdd.json b/change/react-native-windows-908658ce-9dd6-444b-9d6b-b49cd12b2bdd.json
new file mode 100644
index 00000000000..67e73e0b3d9
--- /dev/null
+++ b/change/react-native-windows-908658ce-9dd6-444b-9d6b-b49cd12b2bdd.json
@@ -0,0 +1,7 @@
+{
+  "type": "patch",
+  "comment": "Fix calls to std::mutex::lock",
+  "packageName": "react-native-windows",
+  "email": "vmorozov@microsoft.com",
+  "dependentChangeType": "patch"
+}
diff --git a/vnext/PropertySheets/React.Cpp.props b/vnext/PropertySheets/React.Cpp.props
index 15ed96e5704..f5d391b111b 100644
--- a/vnext/PropertySheets/React.Cpp.props
+++ b/vnext/PropertySheets/React.Cpp.props
@@ -57,6 +57,12 @@
       <PreprocessorDefinitions Condition="'$(UseV8)'=='true'">USE_V8;%(PreprocessorDefinitions)</PreprocessorDefinitions>
       <PreprocessorDefinitions Condition="'$(UseFabric)'=='true'">USE_FABRIC;%(PreprocessorDefinitions)</PreprocessorDefinitions>
       <PreprocessorDefinitions>JSI_VERSION=10;%(PreprocessorDefinitions)</PreprocessorDefinitions>
+      <!--
+        To address the crash on the first call to std::mutex::lock.
+        See: https://github.com/microsoft/STL/wiki/Changelog#vs-2022-1710
+             https://stackoverflow.com/questions/78598141/first-stdmutexlock-crashes-in-application-built-with-latest-visual-studio
+      -->
+      <PreprocessorDefinitions>_DISABLE_CONSTEXPR_MUTEX_CONSTRUCTOR;%(PreprocessorDefinitions)</PreprocessorDefinitions>
     </ClCompile>
   </ItemDefinitionGroup>