diff --git a/mullvad-cli/src/cmds/custom_list.rs b/mullvad-cli/src/cmds/custom_list.rs
index 47e48c0c5f2e..5651ff2d16a9 100644
--- a/mullvad-cli/src/cmds/custom_list.rs
+++ b/mullvad-cli/src/cmds/custom_list.rs
@@ -31,6 +31,7 @@ pub enum CustomList {
         /// A custom list
         name: String,
     },
+    // TODO: Add `clear` command?
 }
 
 #[derive(Subcommand, Debug)]
diff --git a/mullvad-daemon/src/custom_list.rs b/mullvad-daemon/src/custom_list.rs
index c15fd14a701d..ed507468acc5 100644
--- a/mullvad-daemon/src/custom_list.rs
+++ b/mullvad-daemon/src/custom_list.rs
@@ -56,7 +56,7 @@ where
             self.relay_selector
                 .set_config(new_selector_config(&self.settings));
 
-            if self.change_should_cause_reconnect(id) {
+            if self.change_should_cause_reconnect(Some(id)) {
                 log::info!("Initiating tunnel restart because a selected custom list was deleted");
                 self.reconnect_tunnel();
             }
@@ -100,7 +100,7 @@ where
             self.relay_selector
                 .set_config(new_selector_config(&self.settings));
 
-            if self.change_should_cause_reconnect(id) {
+            if self.change_should_cause_reconnect(Some(id)) {
                 log::info!("Initiating tunnel restart because a selected custom list changed");
                 self.reconnect_tunnel();
             }
@@ -110,48 +110,77 @@ where
         Ok(())
     }
 
-    fn change_should_cause_reconnect(&self, custom_list_id: Id) -> bool {
+    pub async fn clear_custom_lists(&mut self) -> Result<(), Error> {
+        let settings_changed = self
+            .settings
+            .update(|settings| {
+                settings.custom_lists.clear();
+            })
+            .await
+            .map_err(Error::SettingsError);
+
+        if let Ok(true) = settings_changed {
+            self.relay_selector
+                .set_config(new_selector_config(&self.settings));
+
+            if self.change_should_cause_reconnect(None) {
+                log::info!("Initiating tunnel restart because a selected custom list was deleted");
+                self.reconnect_tunnel();
+            }
+        }
+
+        settings_changed?;
+        Ok(())
+    }
+
+    /// Check whether we need to reconnect after changing custom lists.
+    ///
+    /// If `custom_list_id` is `Some`, only changes to that custom list will trigger a reconnect.
+    fn change_should_cause_reconnect(&self, custom_list_id: Option<Id>) -> bool {
         use mullvad_types::states::TunnelState;
         let mut need_to_reconnect = false;
 
-        if let RelaySettings::Normal(relay_settings) = &self.settings.relay_settings {
-            if let Constraint::Only(LocationConstraint::CustomList { list_id }) =
-                &relay_settings.location
-            {
-                need_to_reconnect |= list_id == &custom_list_id;
-            }
+        let RelaySettings::Normal(relay_settings) = &self.settings.relay_settings else {
+            return false;
+        };
 
-            if let TunnelState::Connecting {
-                endpoint,
-                location: _,
-            }
-            | TunnelState::Connected {
-                endpoint,
-                location: _,
-            } = &self.tunnel_state
-            {
-                match endpoint.tunnel_type {
-                    TunnelType::Wireguard => {
-                        if relay_settings.wireguard_constraints.multihop() {
-                            if let Constraint::Only(LocationConstraint::CustomList { list_id }) =
-                                &relay_settings.wireguard_constraints.entry_location
-                            {
-                                need_to_reconnect |= list_id == &custom_list_id;
-                            }
+        if let Constraint::Only(LocationConstraint::CustomList { list_id }) =
+            &relay_settings.location
+        {
+            need_to_reconnect |= custom_list_id.map(|id| &id == list_id).unwrap_or(true);
+        }
+
+        if let TunnelState::Connecting {
+            endpoint,
+            location: _,
+        }
+        | TunnelState::Connected {
+            endpoint,
+            location: _,
+        } = &self.tunnel_state
+        {
+            match endpoint.tunnel_type {
+                TunnelType::Wireguard => {
+                    if relay_settings.wireguard_constraints.multihop() {
+                        if let Constraint::Only(LocationConstraint::CustomList { list_id }) =
+                            &relay_settings.wireguard_constraints.entry_location
+                        {
+                            need_to_reconnect |=
+                                custom_list_id.map(|id| &id == list_id).unwrap_or(true);
                         }
                     }
+                }
 
-                    TunnelType::OpenVpn => {
-                        if !matches!(self.settings.bridge_state, BridgeState::Off) {
-                            if let Ok(ResolvedBridgeSettings::Normal(bridge_settings)) =
-                                self.settings.bridge_settings.resolve()
+                TunnelType::OpenVpn => {
+                    if !matches!(self.settings.bridge_state, BridgeState::Off) {
+                        if let Ok(ResolvedBridgeSettings::Normal(bridge_settings)) =
+                            self.settings.bridge_settings.resolve()
+                        {
+                            if let Constraint::Only(LocationConstraint::CustomList { list_id }) =
+                                &bridge_settings.location
                             {
-                                if let Constraint::Only(LocationConstraint::CustomList {
-                                    list_id,
-                                }) = &bridge_settings.location
-                                {
-                                    need_to_reconnect |= list_id == &custom_list_id;
-                                }
+                                need_to_reconnect |=
+                                    custom_list_id.map(|id| &id == list_id).unwrap_or(true);
                             }
                         }
                     }
diff --git a/mullvad-daemon/src/lib.rs b/mullvad-daemon/src/lib.rs
index da02cb6ffc95..365e82efeba1 100644
--- a/mullvad-daemon/src/lib.rs
+++ b/mullvad-daemon/src/lib.rs
@@ -279,6 +279,8 @@ pub enum DaemonCommand {
     DeleteCustomList(ResponseTx<(), Error>, mullvad_types::custom_list::Id),
     /// Update a custom list with a given id
     UpdateCustomList(ResponseTx<(), Error>, CustomList),
+    /// Remove all custom lists
+    ClearCustomLists(ResponseTx<(), Error>),
     /// Add API access methods
     AddApiAccessMethod(
         ResponseTx<mullvad_types::access_method::Id, Error>,
@@ -1255,6 +1257,7 @@ where
             CreateCustomList(tx, name) => self.on_create_custom_list(tx, name).await,
             DeleteCustomList(tx, id) => self.on_delete_custom_list(tx, id).await,
             UpdateCustomList(tx, update) => self.on_update_custom_list(tx, update).await,
+            ClearCustomLists(tx) => self.on_clear_custom_lists(tx).await,
             GetVersionInfo(tx) => self.on_get_version_info(tx),
             AddApiAccessMethod(tx, name, enabled, access_method) => {
                 self.on_add_access_method(tx, name, enabled, access_method)
@@ -2435,6 +2438,11 @@ where
         Self::oneshot_send(tx, result, "update_custom_list response");
     }
 
+    async fn on_clear_custom_lists(&mut self, tx: ResponseTx<(), Error>) {
+        let result = self.clear_custom_lists().await;
+        Self::oneshot_send(tx, result, "clear_custom_lists response");
+    }
+
     async fn on_add_access_method(
         &mut self,
         tx: ResponseTx<mullvad_types::access_method::Id, Error>,
diff --git a/mullvad-daemon/src/management_interface.rs b/mullvad-daemon/src/management_interface.rs
index 52c2c50d4cc2..55573f87a7d1 100644
--- a/mullvad-daemon/src/management_interface.rs
+++ b/mullvad-daemon/src/management_interface.rs
@@ -598,6 +598,16 @@ impl ManagementService for ManagementServiceImpl {
             .map_err(map_daemon_error)
     }
 
+    async fn clear_custom_lists(&self, _: Request<()>) -> ServiceResult<()> {
+        log::debug!("clear_custom_lists");
+        let (tx, rx) = oneshot::channel();
+        self.send_command_to_daemon(DaemonCommand::ClearCustomLists(tx))?;
+        self.wait_for_result(rx)
+            .await?
+            .map(Response::new)
+            .map_err(map_daemon_error)
+    }
+
     // Access Methods
 
     async fn add_api_access_method(
diff --git a/mullvad-management-interface/proto/management_interface.proto b/mullvad-management-interface/proto/management_interface.proto
index cd3e6afaac0c..8af34aa8afe3 100644
--- a/mullvad-management-interface/proto/management_interface.proto
+++ b/mullvad-management-interface/proto/management_interface.proto
@@ -73,6 +73,7 @@ service ManagementService {
   rpc CreateCustomList(google.protobuf.StringValue) returns (google.protobuf.StringValue) {}
   rpc DeleteCustomList(google.protobuf.StringValue) returns (google.protobuf.Empty) {}
   rpc UpdateCustomList(CustomList) returns (google.protobuf.Empty) {}
+  rpc ClearCustomLists(google.protobuf.Empty) returns (google.protobuf.Empty) {}
 
   // Access methods
   rpc AddApiAccessMethod(NewAccessMethodSetting) returns (UUID) {}
diff --git a/mullvad-management-interface/src/client.rs b/mullvad-management-interface/src/client.rs
index 1e9b287f46ac..2244480ba2c2 100644
--- a/mullvad-management-interface/src/client.rs
+++ b/mullvad-management-interface/src/client.rs
@@ -535,6 +535,14 @@ impl MullvadProxyClient {
         Ok(())
     }
 
+    pub async fn clear_custom_lists(&mut self) -> Result<()> {
+        self.0
+            .clear_custom_lists(())
+            .await
+            .map_err(map_custom_list_error)?;
+        Ok(())
+    }
+
     pub async fn add_access_method(
         &mut self,
         name: String,
diff --git a/mullvad-types/src/custom_list.rs b/mullvad-types/src/custom_list.rs
index b92f128a3bd3..89febe81abad 100644
--- a/mullvad-types/src/custom_list.rs
+++ b/mullvad-types/src/custom_list.rs
@@ -98,6 +98,11 @@ impl CustomListsSettings {
     pub fn remove(&mut self, index: usize) {
         self.custom_lists.remove(index);
     }
+
+    /// Remove all custom lists
+    pub fn clear(&mut self) {
+        self.custom_lists.clear();
+    }
 }
 
 impl IntoIterator for CustomListsSettings {
diff --git a/test/test-manager/src/tests/mod.rs b/test/test-manager/src/tests/mod.rs
index e99300232b9f..f4c4563bde08 100644
--- a/test/test-manager/src/tests/mod.rs
+++ b/test/test-manager/src/tests/mod.rs
@@ -171,12 +171,11 @@ pub async fn cleanup_after_test(mullvad_client: &mut MullvadProxyClient) -> anyh
         .await
         .context("Could not clear PQ options in cleanup")?;
 
-    for custom_list in custom_lists {
-        mullvad_client
-            .delete_custom_list(custom_list.name)
-            .await
-            .context("Could not remove custom list")?;
-    }
+    let _ = custom_lists;
+    mullvad_client
+        .clear_custom_lists()
+        .await
+        .context("Could not remove custom list")?;
 
     Ok(())
 }