diff --git a/.github/workflows/wheels.yml b/.github/workflows/wheels.yml
new file mode 100644
index 0000000000..e44967e0a8
--- /dev/null
+++ b/.github/workflows/wheels.yml
@@ -0,0 +1,100 @@
+name: Build NEURON Python wheels
+
+on:
+  push:
+    branches:
+      - master
+  pull_request:
+    branches:
+      - master
+
+  workflow_dispatch:
+    inputs:
+      rel_release:
+        description: Release branch/commit
+        default: 'release/x.y'
+        required: true
+      rel_version:
+        description: Release version (tag name)
+        default: 'x.y.z'
+        required: true
+
+
+jobs:
+  build-test:
+    name: Build Python wheels
+    runs-on: ${{ matrix.os }}
+    timeout-minutes: 60
+    strategy:
+      matrix:
+        os: [macos-14]
+        python-version: ['3.9', '3.10', '3.11', '3.12', '3.13']
+
+    steps:
+      - name: Check out code
+        if: github.event_name != 'workflow_dispatch'
+        uses: actions/checkout@v4
+
+      - name: Check out code for release
+        if: github.event_name == 'workflow_dispatch'
+        uses: actions/checkout@v4
+        with:
+          ref: ${{ github.inputs.rel_release }}
+
+      - uses: actions/setup-python@v5
+        with:
+          python-version: ${{ matrix.python-version }}
+
+      - name: Install MacOS System Dependencies
+        if: startsWith(runner.os, 'macOS')
+        run: |
+          brew install --cask xquartz
+          brew install flex bison mpich
+          brew unlink mpich && brew install openmpi
+          cmake --version
+          # Uninstall libomp for compatibility with issue #817
+          brew uninstall --ignore-dependencies libomp || echo "libomp doesn't exist"
+          brew install cmake
+          echo "$(brew --prefix)/opt/cmake/bin" >> $GITHUB_PATH
+          echo "$(brew --prefix)/opt/flex/bin:$(brew --prefix)/opt/bison/bin" >> $GITHUB_PATH
+
+      - name: Install readline
+        if: startsWith(runner.os, 'macOS')
+        run: |
+          sudo mkdir -p /opt/nrnwheel/$(uname -m)
+          sudo bash packaging/python/build_static_readline_osx.bash
+
+      - name: Set env for release
+        if: github.event_name == 'workflow_dispatch'
+        run: |
+          echo "NRN_NIGHTLY_UPLOAD=false" >> $GITHUB_ENV
+          echo NRN_RELEASE_UPLOAD=${{ github.event.inputs.upload }} >> $GITHUB_ENV
+          echo "NEURON_NIGHTLY_TAG=" >> $GITHUB_ENV
+          echo SETUPTOOLS_SCM_PRETEND_VERSION=${{ github.event.inputs.rel_version }} >> $GITHUB_ENV
+
+      - name: Build wheels on MacOS
+        if: startsWith(runner.os, 'macOS')
+        run: |
+          packaging/python/build_wheels.bash osx ${{ matrix.python-version }} coreneuron
+
+      - name: Test wheel
+        run: |
+          minor_version="$(python -c 'import sys;print(sys.version_info.minor)')"
+          packaging/python/test_wheels.sh $(which python) wheelhouse/*cp3${minor_version}*.whl
+
+      - name: Upload wheel files
+        uses: actions/upload-artifact@v4
+        with:
+          name: wheels-${{ matrix.python-version }}-${{ matrix.os }}
+          path: wheelhouse/*.whl
+
+  merge:
+    runs-on: ubuntu-latest
+    needs: build-test
+    steps:
+      - name: Merge Artifacts
+        uses: actions/upload-artifact/merge@v4
+        with:
+          delete-merged: true
+          name: wheels
+          pattern: wheels-*