diff --git a/packages_rs/nextclade-web/package.json b/packages_rs/nextclade-web/package.json
index c4a7c2969..5adc69e4c 100644
--- a/packages_rs/nextclade-web/package.json
+++ b/packages_rs/nextclade-web/package.json
@@ -86,6 +86,7 @@
     "types:generate": "yarn run:node:prod tools/generateTypes.js -i src/gen/_SchemaRoot.json -o src/gen/_SchemaRoot.d.ts"
   },
   "dependencies": {
+    "@floating-ui/react": "0.26.1",
     "animate.css": "4.1.1",
     "auspice": "2.51.0",
     "autoprefixer": "10.4.5",
diff --git a/packages_rs/nextclade-web/src/components/Common/CardCollapsible.tsx b/packages_rs/nextclade-web/src/components/Common/CardCollapsible.tsx
index 0a55f3e6e..caf78560d 100644
--- a/packages_rs/nextclade-web/src/components/Common/CardCollapsible.tsx
+++ b/packages_rs/nextclade-web/src/components/Common/CardCollapsible.tsx
@@ -11,7 +11,7 @@ export interface CardCollapsibleProps extends PropsWithChildren<CardProps> {
 }
 
 export function CardCollapsible({ header, children, defaultCollapsed = true, ...restProps }: CardCollapsibleProps) {
-  const [collapsed, toggleCollapsed] = useToggle(defaultCollapsed)
+  const { state: collapsed, toggle: toggleCollapsed } = useToggle(defaultCollapsed)
   const isOpen = useMemo(() => !collapsed && !!children, [children, collapsed])
   const Icon = useMemo(
     () => <ArrowIcon color={children ? '#999' : 'transparent'} size={22} $rotated={isOpen} />,
diff --git a/packages_rs/nextclade-web/src/components/Common/InfoButton.tsx b/packages_rs/nextclade-web/src/components/Common/InfoButton.tsx
new file mode 100644
index 000000000..6d079fa97
--- /dev/null
+++ b/packages_rs/nextclade-web/src/components/Common/InfoButton.tsx
@@ -0,0 +1,87 @@
+import React, { PropsWithChildren } from 'react'
+import { Button as ButtonBase, CardBody } from 'reactstrap'
+import styled, { useTheme } from 'styled-components'
+import { FaInfo as InfoIcon } from 'react-icons/fa6'
+import { useTranslationSafe } from 'src/helpers/useTranslationSafe'
+import { useToggle } from 'src/hooks/useToggle'
+import {
+  useFloating,
+  useInteractions,
+  useFocus,
+  useDismiss,
+  useRole,
+  FloatingPortal,
+  autoPlacement,
+} from '@floating-ui/react'
+
+export interface InfoButtonProps {
+  size?: number
+}
+
+export function InfoButton({ size = 18, children }: PropsWithChildren<InfoButtonProps>) {
+  const { t } = useTranslationSafe()
+  const theme = useTheme()
+
+  const { state: isOpen, toggle, setState: setIsOpen } = useToggle(false)
+  const { refs, context, floatingStyles } = useFloating({
+    open: isOpen,
+    onOpenChange: setIsOpen,
+    middleware: [autoPlacement()],
+  })
+  const dismiss = useDismiss(context)
+  const focus = useFocus(context)
+  const role = useRole(context)
+  const { getReferenceProps, getFloatingProps } = useInteractions([focus, dismiss, role])
+
+  return (
+    <>
+      <Button
+        innerRef={refs.setReference} // NOTE: using `innerRef` to pass ref to `reactstrap` component underneath.
+        as={ButtonBase} // NOTE: this works with styled-components v5, but "as" prop is removed in v6.
+        title={t('Click to get help information')}
+        $size={size}
+        {...getReferenceProps({ onClick: toggle })}
+      >
+        <Icon color={theme.primary} size={size * 0.66} />
+      </Button>
+      {isOpen && (
+        <FloatingPortal>
+          <Floating ref={refs.setFloating} style={floatingStyles} {...getFloatingProps()}>
+            <Card>
+              <CardBody>{children}</CardBody>
+            </Card>
+          </Floating>
+        </FloatingPortal>
+      )}
+    </>
+  )
+}
+
+const Floating = styled.div`
+  z-index: 1005;
+  width: 500px;
+  max-width: 80vw;
+  max-height: 80vh;
+`
+
+const Card = styled.div`
+  overflow-y: auto;
+  box-shadow: 1px 1px 10px 5px #0005;
+  border-radius: 5px;
+  height: 100%;
+  background-color: ${(props) => props.theme.bodyBg};
+`
+
+const Button = styled.button<{ $size?: number }>`
+  display: flex;
+  width: ${(props) => props.$size}px;
+  height: ${(props) => props.$size}px;
+  border-radius: ${(props) => props.$size}px;
+  padding: 0 !important;
+  margin: auto 0.5rem;
+`
+
+const Icon = styled(InfoIcon)`
+  padding: 0 !important;
+  margin: auto !important;
+`
diff --git a/packages_rs/nextclade-web/src/components/Help/SelectDatasetHelp.tsx b/packages_rs/nextclade-web/src/components/Help/SelectDatasetHelp.tsx
new file mode 100644
index 000000000..953417c9f
--- /dev/null
+++ b/packages_rs/nextclade-web/src/components/Help/SelectDatasetHelp.tsx
@@ -0,0 +1,44 @@
+import React from 'react'
+import { useTranslationSafe } from 'src/helpers/useTranslationSafe'
+import { InfoButton } from 'src/components/Common/InfoButton'
+import { LinkExternal } from 'src/components/Link/LinkExternal'
+
+export function SelectDatasetHelp() {
+  const { t } = useTranslationSafe()
+
+  return (
+    <InfoButton>
+      <p>
+        {t(
+          'Nextclade software is built to be agnostic to pathogens it analyzes. The information about concrete pathogens is provided in the form of so-called Nextclade datasets.',
+        )}
+      </p>
+
+      <p>
+        {t(
+          'Datasets vary by the pathogen, strain and other attributes. Each dataset is based on a particular reference sequence. Certain datasets only have enough information for basic analysis, others - more information to allow for more in-depth analysis and checks. Dataset authors periodically update and improve their datasets.',
+        )}
+      </p>
+
+      <p>
+        {t(
+          'You can select one of the datasets manually or to use automatic dataset suggestion function. Automatic suggestion will attempt to guess the most appropriate dataset from your sequence data.',
+        )}
+      </p>
+
+      <p>
+        {t(
+          "If you don't find a dataset for a pathogen or a strain you need, then you can create your own dataset. You can also publish it to our community collection, so that other people can use it too.",
+        )}
+      </p>
+
+      <p>
+        {t('Learn more about Nextclade datasets in the {{documentation}}')}
+        <LinkExternal href="https://docs.nextstrain.org/projects/nextclade/en/stable/user/datasets.html">
+          {t('documentation')}
+        </LinkExternal>
+        {t('.')}
+      </p>
+    </InfoButton>
+  )
+}
diff --git a/packages_rs/nextclade-web/src/components/Main/DatasetSelector.tsx b/packages_rs/nextclade-web/src/components/Main/DatasetSelector.tsx
index 227692a61..8f2c44767 100644
--- a/packages_rs/nextclade-web/src/components/Main/DatasetSelector.tsx
+++ b/packages_rs/nextclade-web/src/components/Main/DatasetSelector.tsx
@@ -1,6 +1,7 @@
 import React, { useEffect, useState } from 'react'
 import { useRecoilState } from 'recoil'
 import { Container as ContainerBase } from 'reactstrap'
+import { SelectDatasetHelp } from 'src/components/Help/SelectDatasetHelp'
 import { DatasetSelectorList } from 'src/components/Main/DatasetSelectorList'
 import { SuggestionPanel } from 'src/components/Main/SuggestionPanel'
 import { useDatasetSuggestionResults } from 'src/hooks/useRunSeqAutodetect'
@@ -56,7 +57,10 @@ export function DatasetSelectorImpl({
   return (
     <Container>
       <Header>
-        <Title>{t('Select dataset')}</Title>
+        <Title>
+          <H4Inline>{t('Select dataset')}</H4Inline>
+          <SelectDatasetHelp />
+        </Title>
 
         <SearchBox searchTitle={t('Search datasets')} searchTerm={searchTerm} onSearchTermChange={setSearchTerm} />
       </Header>
@@ -104,6 +108,11 @@ const Main = styled.div`
 `
 
 const Title = styled.h4`
+  display: flex;
   flex: 1;
+`
+
+const H4Inline = styled.h4`
+  display: inline-flex;
   margin: auto 0;
 `
diff --git a/packages_rs/nextclade-web/src/components/Main/MainInputForm.tsx b/packages_rs/nextclade-web/src/components/Main/MainInputForm.tsx
index bd81f26a7..e51177de5 100644
--- a/packages_rs/nextclade-web/src/components/Main/MainInputForm.tsx
+++ b/packages_rs/nextclade-web/src/components/Main/MainInputForm.tsx
@@ -2,12 +2,13 @@ import { useRouter } from 'next/router'
 import React, { useCallback, useEffect, useMemo } from 'react'
 import { isNil } from 'lodash'
 import { useRecoilState, useRecoilValue } from 'recoil'
+import styled from 'styled-components'
+import { SelectDatasetHelp } from 'src/components/Help/SelectDatasetHelp'
 import { ButtonRun } from 'src/components/Main/ButtonRun'
 import { SuggestionPanel } from 'src/components/Main/SuggestionPanel'
 import { useRunAnalysis } from 'src/hooks/useRunAnalysis'
 import { AutodetectRunState, autodetectRunStateAtom } from 'src/state/autodetect.state'
 import { shouldSuggestDatasetsOnDatasetPageAtom } from 'src/state/settings.state'
-import styled from 'styled-components'
 import { hasRequiredInputsAtom } from 'src/state/inputs.state'
 import { datasetCurrentAtom } from 'src/state/dataset.state'
 import { DatasetCurrentSummary } from 'src/components/Main/DatasetCurrentSummary'
@@ -133,7 +134,10 @@ function DatasetCurrentOrSelectButton({ toDatasetSelection }: DatasetCurrentOrSe
     return (
       <Container>
         <Header>
-          <h4>{text}</h4>
+          <Title>
+            <H4Inline>{text}</H4Inline>
+            <SelectDatasetHelp />
+          </Title>
         </Header>
 
         <Main>
@@ -150,7 +154,10 @@ function DatasetCurrentOrSelectButton({ toDatasetSelection }: DatasetCurrentOrSe
   return (
     <Container>
       <Header>
-        <h4>{text}</h4>
+        <Title>
+          <H4Inline>{text}</H4Inline>
+          <SelectDatasetHelp />
+        </Title>
       </Header>
 
       <Main>
@@ -168,3 +175,13 @@ function DatasetCurrentOrSelectButton({ toDatasetSelection }: DatasetCurrentOrSe
     </Container>
   )
 }
+
+const Title = styled.h4`
+  display: flex;
+  flex: 1;
+`
+
+const H4Inline = styled.h4`
+  display: inline-flex;
+  margin: auto 0;
+`
diff --git a/packages_rs/nextclade-web/src/hooks/useToggle.ts b/packages_rs/nextclade-web/src/hooks/useToggle.ts
index da562079c..ce807e935 100644
--- a/packages_rs/nextclade-web/src/hooks/useToggle.ts
+++ b/packages_rs/nextclade-web/src/hooks/useToggle.ts
@@ -3,12 +3,12 @@ import { RecoilState, useRecoilState } from 'recoil'
 
 export type VoidFunc = () => void
 
-export function useToggle(initialState = false): [boolean, VoidFunc, VoidFunc, VoidFunc] {
+export function useToggle(initialState = false) {
   const [state, setState] = useState(initialState)
   const toggle = useCallback(() => setState((state) => !state), [])
   const enable = useCallback(() => setState(true), [])
   const disable = useCallback(() => setState(false), [])
-  return [state, toggle, enable, disable]
+  return { state, setState, toggle, enable, disable }
 }
 
 export function useRecoilToggle(recoilState: RecoilState<boolean>) {
diff --git a/packages_rs/nextclade-web/yarn.lock b/packages_rs/nextclade-web/yarn.lock
index c57aa3353..a3c29efe9 100644
--- a/packages_rs/nextclade-web/yarn.lock
+++ b/packages_rs/nextclade-web/yarn.lock
@@ -2074,6 +2074,42 @@
     minimatch "^3.0.4"
     strip-json-comments "^3.1.1"
 
+"@floating-ui/core@^1.4.2":
+  version "1.5.0"
+  resolved "https://registry.yarnpkg.com/@floating-ui/core/-/core-1.5.0.tgz#5c05c60d5ae2d05101c3021c1a2a350ddc027f8c"
+  integrity sha512-kK1h4m36DQ0UHGj5Ah4db7R0rHemTqqO0QLvUqi1/mUUp3LuAWbWxdxSIf/XsnH9VS6rRVPLJCncjRzUvyCLXg==
+  dependencies:
+    "@floating-ui/utils" "^0.1.3"
+
+"@floating-ui/dom@^1.5.1":
+  version "1.5.3"
+  resolved "https://registry.yarnpkg.com/@floating-ui/dom/-/dom-1.5.3.tgz#54e50efcb432c06c23cd33de2b575102005436fa"
+  integrity sha512-ClAbQnEqJAKCJOEbbLo5IUlZHkNszqhuxS4fHAVxRPXPya6Ysf2G8KypnYcOTpx6I8xcgF9bbHb6g/2KpbV8qA==
+  dependencies:
+    "@floating-ui/core" "^1.4.2"
+    "@floating-ui/utils" "^0.1.3"
+
+"@floating-ui/react-dom@^2.0.2":
+  version "2.0.2"
+  resolved "https://registry.yarnpkg.com/@floating-ui/react-dom/-/react-dom-2.0.2.tgz#fab244d64db08e6bed7be4b5fcce65315ef44d20"
+  integrity sha512-5qhlDvjaLmAst/rKb3VdlCinwTF4EYMiVxuuc/HVUjs46W0zgtbMmAZ1UTsDrRTxRmUEzl92mOtWbeeXL26lSQ==
+  dependencies:
+    "@floating-ui/dom" "^1.5.1"
+
+"@floating-ui/react@0.26.1":
+  version "0.26.1"
+  resolved "https://registry.yarnpkg.com/@floating-ui/react/-/react-0.26.1.tgz#a790bd3cff5f334d9e87d3ec132a3dc39d937800"
+  integrity sha512-5gyJIJ2tZOPMgmZ/vEcVhdmQiy75b7LPO71sYIiDsxGcZ4hxLuygQWCuT0YXHqppt//Eese+L6t5KnX/gZ3tVA==
+  dependencies:
+    "@floating-ui/react-dom" "^2.0.2"
+    "@floating-ui/utils" "^0.1.5"
+    tabbable "^6.0.1"
+
+"@floating-ui/utils@^0.1.3", "@floating-ui/utils@^0.1.5":
+  version "0.1.6"
+  resolved "https://registry.yarnpkg.com/@floating-ui/utils/-/utils-0.1.6.tgz#22958c042e10b67463997bd6ea7115fe28cbcaf9"
+  integrity sha512-OfX7E2oUDYxtBvsuS4e/jSn4Q9Qb6DzgeYtsAdkPZ47znpoNsMgZw0+tVijiv3uGNR6dgNlty6r9rzIzHjtd/A==
+
 "@google-cloud/common@^3.0.0":
   version "3.10.0"
   resolved "https://registry.yarnpkg.com/@google-cloud/common/-/common-3.10.0.tgz#454d1155bb512109cd83c6183aabbd39f9aabda7"
@@ -15425,6 +15461,11 @@ synesthesia@^1.0.1:
   dependencies:
     css-color-names "0.0.3"
 
+tabbable@^6.0.1:
+  version "6.2.0"
+  resolved "https://registry.yarnpkg.com/tabbable/-/tabbable-6.2.0.tgz#732fb62bc0175cfcec257330be187dcfba1f3b97"
+  integrity sha512-Cat63mxsVJlzYvN51JmVXIgNoUokrIaT2zLclCXjRd8boZ0004U4KCs/sToJ75C6sdlByWxpYnb5Boif1VSFew==
+
 table@^6.6.0, table@^6.8.0:
   version "6.8.0"
   resolved "https://registry.yarnpkg.com/table/-/table-6.8.0.tgz#87e28f14fa4321c3377ba286f07b79b281a3b3ca"