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It can be argued that under standard assumptions of hardware design (e.g. "cost of b-state circuit" is proportional to b) the most efficient base is 𝑒.
However, it is not practical.
Meanwhile, base 2 is only 5% more costly than base 3 and only 6% more costly than base 𝑒.
Which is an interesting result, given base 2 is both convenient to use and is theoretically optimal.