Answer

Shodan has serveral filters for the HTTP protocol.

http.component
http.component_category
http.favicon.hash
http.html
http.html_hash
http.robots_hash
http.securitytxt
http.status
http.title
http.waf

You can use http.html_hash filter for filtering results by a hash of the HTML.

Shodan uses MurmurHash3 as a hashing function.

In Python, you can use mmh3 for calculating MurmurHash3.

import mmh3
mmh3.hash('foo') # 32 bit signed int
# -156908512

Let's take an HTML of http://example.com as an input.

import mmh3
import requests

res = requests.get("http://example.com")
html = res.text
print(mmh3.hash(html))
# -2087618365

The answer is http.html_hash:-2087618365.