diff --git a/nipype/interfaces/mrtrix3/tests/test_auto_TckSift2.py b/nipype/interfaces/mrtrix3/tests/test_auto_TckSift2.py
new file mode 100644
index 0000000000..7ee92fa257
--- /dev/null
+++ b/nipype/interfaces/mrtrix3/tests/test_auto_TckSift2.py
@@ -0,0 +1,50 @@
+# AUTO-GENERATED by tools/checkspecs.py - DO NOT EDIT
+from ..utils import TckSift2
+
+
+def test_TckSift2_inputs():
+    input_map = dict(
+        args=dict(
+            argstr="%s",
+        ),
+        environ=dict(
+            nohash=True,
+            usedefault=True,
+        ),
+        in_file=dict(
+            argstr="%s",
+            extensions=None,
+            mandatory=True,
+            position=-3,
+        ),
+        in_fod=dict(
+            argstr="%s",
+            extensions=None,
+            mandatory=True,
+            position=-2,
+        ),
+        out_weights=dict(
+            argstr="%s",
+            extensions=None,
+            mandatory=True,
+            position=-1,
+        ),
+    )
+    inputs = TckSift2.input_spec()
+
+    for key, metadata in list(input_map.items()):
+        for metakey, value in list(metadata.items()):
+            assert getattr(inputs.traits()[key], metakey) == value
+
+
+def test_TckSift2_outputs():
+    output_map = dict(
+        out_weights=dict(
+            extensions=None,
+        ),
+    )
+    outputs = TckSift2.output_spec()
+
+    for key, metadata in list(output_map.items()):
+        for metakey, value in list(metadata.items()):
+            assert getattr(outputs.traits()[key], metakey) == value
diff --git a/nipype/interfaces/mrtrix3/utils.py b/nipype/interfaces/mrtrix3/utils.py
index 8a69232ecd..0a71e9c8f9 100644
--- a/nipype/interfaces/mrtrix3/utils.py
+++ b/nipype/interfaces/mrtrix3/utils.py
@@ -1,7 +1,6 @@
 # emacs: -*- mode: python; py-indent-offset: 4; indent-tabs-mode: nil -*-
 # vi: set ft=python sts=4 ts=4 sw=4 et:
 # -*- coding: utf-8 -*-
-
 import os.path as op
 
 from ...utils.filemanip import split_filename
@@ -19,6 +18,43 @@
 from .base import MRTrix3BaseInputSpec, MRTrix3Base
 
 
+class TckSift2InputSpec(CommandLineInputSpec):
+    in_file = File(exists=True, argstr="%s", mandatory=True, position=-3, desc="input streamlines file")
+    in_fod = File(exists=True, argstr="%s", mandatory=True, position=-2, desc="input FOD file")
+    out_weights = File(argstr="%s", mandatory=True, position=-1, desc="output weights file")
+
+
+class TckSift2OutputSpec(TraitedSpec):
+    out_weights = File(exists=True, desc="output weights file")
+
+
+class TckSift2(CommandLine):
+    """
+    Interface for MRTrix's tcksift2 command
+
+    Example
+    -------
+
+    >>> import nipype.interfaces.mrtrix3 as mrt
+    >>> tcksift2 = mrt.TckSift2()
+    >>> tcksift2.inputs.in_file = 'streamlines.tck'
+    >>> tcksift2.inputs.in_fod = 'fod.mif'
+    >>> tcksift2.inputs.out_weights = 'streamlines_weights.txt'
+    >>> tcksift2.cmdline
+    'tcksift2 streamlines.tck fod.mif streamlines_weights.txt'
+    >>> tcksift2.run()                                 # doctest: +SKIP
+    """
+        
+    _cmd = 'tcksift2'
+    input_spec = TckSift2InputSpec
+    output_spec = TckSift2OutputSpec
+    
+    def _list_outputs(self):
+        outputs = self.output_spec().get()
+        outputs["out_weights"] = op.abspath(self.inputs.out_weights)
+        return outputs
+
+
 class BrainMaskInputSpec(MRTrix3BaseInputSpec):
     in_file = File(
         exists=True,