diff --git a/boot/zephyr/boards/thingy53_nrf5340_cpuapp.conf b/boot/zephyr/boards/thingy53_nrf5340_cpuapp.conf
index 7d3bc0bec..e10656678 100644
--- a/boot/zephyr/boards/thingy53_nrf5340_cpuapp.conf
+++ b/boot/zephyr/boards/thingy53_nrf5340_cpuapp.conf
@@ -21,6 +21,7 @@ CONFIG_UART_LINE_CTRL=y
 
 # MCUBoot serial
 CONFIG_GPIO=y
+CONFIG_GPIO_NRFX_INTERRUPT=n
 CONFIG_MCUBOOT_SERIAL=y
 CONFIG_MCUBOOT_SERIAL_DIRECT_IMAGE_UPLOAD=y
 CONFIG_BOOT_SERIAL_CDC_ACM=y