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<Description>Annotator Entity Relationship Notation</Description>
<ObjectType uniqueId="118" name="Note" classification="Shape">
<description>Annotation</description>
</ObjectType>
<ObjectType uniqueId="117" name="Acceptor" classification="Shape">
<description>acceptor of influence link</description>
</ObjectType>
<ObjectType uniqueId="116" name="Decision" classification="Shape">
<description>agregator for several state assignments</description>
</ObjectType>
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<description>DelayGate</description>
</ObjectType>
<ObjectType uniqueId="114" name="Observable" classification="Shape">
<description>Observable</description>
</ObjectType>
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<description>Perturbing Agent</description>
</ObjectType>
<ObjectType uniqueId="105" name="NonInteraction" classification="Shape">
<description>NonInteraction entity</description>
</ObjectType>
<ObjectType uniqueId="125" name="NOT" classification="Shape">
<description>NOT Logical Operator</description>
</ObjectType>
<ObjectType uniqueId="123" name="AND" classification="Shape">
<description>AndGate</description>
</ObjectType>
<ObjectType uniqueId="124" name="OR" classification="Shape">
<description>OR Logical Operator</description>
</ObjectType>
<ObjectType uniqueId="0" name="ROOT_OBJECT" classification="Root">
<description>No descn</description>
</ObjectType>
<ObjectType uniqueId="221" name="AbsStimulation" classification="Link">
<description>A Absolute Stimulation effect, or absolute stimulation, is a stimulation that is necessary for a process to take place.</description>
</ObjectType>
<ObjectType uniqueId="10" name="State" classification="Shape">
<description>State variable value</description>
</ObjectType>
<ObjectType uniqueId="11" name="LocState" classification="Shape">
<description>Location State variable</description>
</ObjectType>
<ObjectType uniqueId="12" name="ExState" classification="Shape">
<description>Existence State variable</description>
</ObjectType>
<ObjectType uniqueId="13" name="Unit Of Information" classification="Shape">
<description>Auxiliary information box</description>
</ObjectType>
<ObjectType uniqueId="14" name="Entity" classification="Shape">
<description>Interacting entity</description>
</ObjectType>
<ObjectType uniqueId="15" name="Interaction" classification="Shape">
<description>Interacting entity</description>
</ObjectType>
<ObjectType uniqueId="16" name="Outcome" classification="Shape">
<description>Interaction outcome</description>
</ObjectType>
<ObjectType uniqueId="20" name="Modulation" classification="Link">
<description>A modulation affects the flux of a process represented by the target transition.</description>
</ObjectType>
<ObjectType uniqueId="21" name="Stimulation" classification="Link">
<description>A stimulation affects positively the flux of a process represented by the target transition.</description>
</ObjectType>
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<description>An absolute inhibition block the flux of a process represented by the target transition.</description>
</ObjectType>
<ObjectType uniqueId="23" name="Inhibition" classification="Link">
<description>An inhibition affects negatively the flux of a process represented by the target transition.</description>
</ObjectType>
<ObjectType uniqueId="26" name="LogicArc" classification="Link">
<description>Logic arc is the arc used to represent the fact that an entity influences outcome of logic operator.</description>
</ObjectType>
<ObjectType uniqueId="25" name="NecessaryStimulation" classification="Link">
<description>A Necessary Stimulation effect, or absolute stimulation, is a stimulation that is necessary for a process to take place.</description>
</ObjectType>
<ObjectType uniqueId="28" name="AssignmenArc" classification="Link">
<description>Assignment arc is the arc.</description>
</ObjectType>
<ObjectType uniqueId="27" name="InteractionArc" classification="Link">
<description>Interaction arc is the arc.</description>
</ObjectType>
<ObjectType uniqueId="29" name="VarArc" classification="Link">
<description>Arc is the arc connecting state value to decision point or state variable to outcome or two outcomes or outcome to decision point.</description>
</ObjectType>
<ObjectType uniqueId="271" name="SInteractionArc" classification="Link">
<description>Interaction arc is the arc.</description>
</ObjectType>
<ObjectType uniqueId="210" name="AnnotationArc" classification="Link">
<description>Annotation Arc is the arc used to connetc Annotation ot entity it annotates.</description>
</ObjectType>
</Notation>
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The reduction in <b>ACE2</b> (<span color='blue' font='mname'>ACE2</span>) mRNA by ANG II or ET-1 was blocked by inhibitors of <b>mitogen-activated protein kinase kinase 1</b> (<span color='red' font='mname'>MAP2K1</span>) , suggesting that ANG II or ET-1 activates extracellular signal-regulated kinase (ERK) 1/ERK2 to reduce <b>ACE2</b> (<span color='blue' font='mname'>ACE2</span>) .	true	true	false	 The reduction in ACE2 mRNA by ANG II or ET-1 was blocked by inhibitors of mitogen-activated protein kinase kinase 1 , suggesting that ANG II or ET-1 activates extracellular signal-regulated kinase (ERK) 1/ERK2 to reduce ACE2 ."/>
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Activation of <b>adenosine A1 receptor</b> (<span color='blue' font='mname'>ADORA1</span>) -induced neural stem cell proliferation via <b>MEK</b> (<span color='red' font='mname'>MAP2K1</span>) /ERK and Akt signaling pathways.	true	true	false	 Activation of adenosine A1 receptor -induced neural stem cell proliferation via MEK /ERK and Akt signaling pathways."/>
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The treatment of BMMSC with <b>MEK</b> (<span color='red' font='mname'>MAP2K1</span>) inhibitor up-regulated the expression of alpha-smooth muscle actin (<b>ASMA</b> (<span color='blue' font='mname'>ACTA1</span>) ), h-caldesmon, and SMMHC in BMMSC in low serum condition.	true	true	false	 The treatment of BMMSC with MEK inhibitor up-regulated the expression of alpha-smooth muscle actin (ASMA ), h-caldesmon, and SMMHC in BMMSC in low serum condition."/>
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<b>PACAP</b> (<span color='blue' font='mname'>ADCYAP1</span>) -induced neuritogenesis was blocked by the <b>MEK1</b> (<span color='red' font='mname'>MAP2K1</span>) inhibitor PD98059 and partially by the p38 MAP kinase inhibitor SB203580.	true	true	false	 PACAP -induced neuritogenesis was blocked by the MEK1 inhibitor PD98059 and partially by the p38 MAP kinase inhibitor SB203580."/>
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