diff --git a/cl.obo b/cl.obo index 0d07b8684..35d18b4c6 100644 --- a/cl.obo +++ b/cl.obo @@ -1,5 +1,5 @@ format-version: 1.2 -data-version: releases/2021-06-21 +data-version: releases/2021-06-28 subsetdef: 1_STAR "" subsetdef: 3_STAR "" subsetdef: abnormal_slim "" @@ -74,7 +74,7 @@ property_value: dc-description "An ontology of cell types." xsd:string property_value: dc-title "Cell Ontology" xsd:string property_value: dcterms-license http://creativecommons.org/licenses/by/4.0/ property_value: IAO:0000700 CL:0000000 -property_value: owl:versionInfo "2021-06-21" xsd:string +property_value: owl:versionInfo "2021-06-28" xsd:string [Term] id: BFO:0000002 @@ -109,6 +109,20 @@ name: process def: "An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t." [] is_a: BFO:0000003 ! occurrent +[Term] +id: BFO:0000016 +name: disposition +is_a: BFO:0000017 ! realizable entity +disjoint_from: BFO:0000023 ! role + +[Term] +id: BFO:0000017 +name: realizable entity +def: "A specifically dependent continuant that inheres in continuant entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances." [] +is_a: BFO:0000020 ! specifically dependent continuant +disjoint_from: BFO:0000019 ! quality +relationship: part_of BFO:0000017 ! realizable entity + [Term] id: BFO:0000019 name: quality @@ -124,6 +138,12 @@ is_a: BFO:0000002 ! continuant disjoint_from: BFO:0000031 ! generically dependent continuant relationship: part_of BFO:0000020 ! specifically dependent continuant +[Term] +id: BFO:0000023 +name: role +def: "A realizable entity the manifestation of which brings about some result or end that is not essential to a continuant in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant in some kinds of natural, social or institutional contexts." [] +is_a: BFO:0000017 ! realizable entity + [Term] id: BFO:0000024 name: fiat object part @@ -143,6 +163,11 @@ def: "A continuant that is dependent on one or other independent continuant bear is_a: BFO:0000002 ! continuant relationship: part_of BFO:0000031 ! generically dependent continuant +[Term] +id: BFO:0000034 +name: function +is_a: BFO:0000016 ! disposition + [Term] id: BFO:0000040 name: material entity @@ -1469,23 +1494,10 @@ synonym: "polymorphonuclear leucocyte" BROAD [] synonym: "polymorphonuclear leukocyte" BROAD [] is_a: CL:0000145 ! professional antigen presenting cell is_a: CL:0000771 {is_inferred="true"} ! eosinophil -intersection_of: CL:0000771 ! eosinophil -intersection_of: capable_of GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II -intersection_of: capable_of GO:0002540 ! leukotriene production involved in inflammatory response -intersection_of: capable_of GO:0045730 ! respiratory burst -intersection_of: has_part GO:0098537 ! obsolete lobed nucleus -intersection_of: has_part PR:000007152 ! eosinophil peroxidase -intersection_of: has_part PR:000007857 ! erythroid transcription factor -intersection_of: has_part PR:000007858 ! endothelial transcription factor GATA-2 -intersection_of: has_part PR:000014046 ! non-secretory ribonuclease -intersection_of: has_part PR:000014047 ! eosinophil cationic protein -intersection_of: has_part PR:000022006 ! eosinophil granule major basic protein -intersection_of: RO:0002104 PR:000009129 ! has plasma membrane part integrin alpha-4 relationship: capable_of GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II relationship: capable_of GO:0002540 ! leukotriene production involved in inflammatory response relationship: capable_of GO:0045730 ! respiratory burst relationship: develops_from CL:0000774 ! band form eosinophil -relationship: has_part GO:0098537 ! obsolete lobed nucleus relationship: has_part PR:000007152 ! eosinophil peroxidase relationship: has_part PR:000007857 ! erythroid transcription factor relationship: has_part PR:000007858 ! endothelial transcription factor GATA-2 @@ -1533,15 +1545,6 @@ xref: BTO:0001026 xref: CALOHA:TS-0688 is_a: CL:0000767 {is_inferred="true"} ! basophil is_a: CL:0002274 ! histamine secreting cell -intersection_of: CL:0000767 ! basophil -intersection_of: capable_of GO:0002349 ! histamine production involved in inflammatory response -intersection_of: capable_of GO:0002351 ! serotonin production involved in inflammatory response -intersection_of: capable_of GO:0002830 ! positive regulation of type 2 immune response -intersection_of: capable_of GO:0008015 ! blood circulation -intersection_of: capable_of GO:0032616 ! interleukin-13 production -intersection_of: capable_of GO:0032633 ! interleukin-4 production -intersection_of: capable_of GO:0048295 ! positive regulation of isotype switching to IgE isotypes -intersection_of: has_part GO:0098537 ! obsolete lobed nucleus relationship: capable_of GO:0002349 ! histamine production involved in inflammatory response relationship: capable_of GO:0002351 ! serotonin production involved in inflammatory response relationship: capable_of GO:0002830 ! positive regulation of type 2 immune response @@ -1549,7 +1552,6 @@ relationship: capable_of GO:0032616 ! interleukin-13 production relationship: capable_of GO:0032633 ! interleukin-4 production relationship: capable_of GO:0048295 ! positive regulation of isotype switching to IgE isotypes relationship: develops_from CL:0000770 ! band form basophil -relationship: has_part GO:0098537 ! obsolete lobed nucleus [Term] id: CL:0000045 @@ -2208,30 +2210,11 @@ synonym: "polynuclear neutrophilic leukocyte" EXACT [] xref: BTO:0003473 is_a: CL:0000234 ! phagocyte is_a: CL:0000775 {is_inferred="true"} ! neutrophil -intersection_of: CL:0000775 ! neutrophil -intersection_of: capable_of GO:0002536 ! respiratory burst involved in inflammatory response -intersection_of: capable_of GO:0002690 ! positive regulation of leukocyte chemotaxis -intersection_of: capable_of GO:0006909 ! phagocytosis -intersection_of: capable_of GO:0032637 ! interleukin-8 production -intersection_of: has_part CP:0000000 ! neutrophillic cytoplasm -intersection_of: has_part GO:0070820 ! tertiary granule -intersection_of: has_part GO:0098537 ! obsolete lobed nucleus -intersection_of: lacks_part PR:000009978 ! lactotransferrin -intersection_of: lacks_part PR:000010543 ! myeloperoxidase -intersection_of: lacks_part PR:000010799 ! myb proto-oncogene protein -intersection_of: RO:0002104 PR:000001256 ! has plasma membrane part C-X-C chemokine receptor type 1 -intersection_of: RO:0002104 PR:000001257 ! has plasma membrane part C-X-C chemokine receptor type 2 -intersection_of: RO:0002104 PR:000001456 ! has plasma membrane part alpha-(1,3)-fucosyltransferase 4 -intersection_of: RO:0002104 PR:000001483 ! has plasma membrane part low affinity immunoglobulin gamma Fc region receptor III -intersection_of: RO:0002104 PR:000001879 ! has plasma membrane part leukosialin -intersection_of: RO:0002104 PR:000001944 ! has plasma membrane part transcription factor PU.1 -intersection_of: RO:0002104 PR:000007597 ! has plasma membrane part proto-oncogene c-Fos relationship: capable_of GO:0002536 ! respiratory burst involved in inflammatory response relationship: capable_of GO:0002690 ! positive regulation of leukocyte chemotaxis relationship: capable_of GO:0032637 ! interleukin-8 production relationship: has_part CP:0000000 ! neutrophillic cytoplasm relationship: has_part GO:0070820 ! tertiary granule -relationship: has_part GO:0098537 ! obsolete lobed nucleus relationship: lacks_part PR:000009978 ! lactotransferrin relationship: lacks_part PR:000010543 ! myeloperoxidase relationship: lacks_part PR:000010799 ! myb proto-oncogene protein @@ -5266,14 +5249,16 @@ is_a: CL:0000402 ! CNS interneuron [Term] id: CL:0000411 -name: flatworm hypodermal cell +name: Caenorhabditis hypodermal cell namespace: cell -def: "An epithelial cell of the hypodermis of flatworms." [GOC:tfm, http://www.wormatlas.org/hermaphrodite/hypodermis/mainframe.htm] +def: "An epithelial cell of the hypodermis of Caenorhabditis." [GOC:tfm, http://www.wormatlas.org/hermaphrodite/hypodermis/mainframe.htm] +comment: This term was originally added to CL for parity with the Worm anatomy ontology, which is dedicated to C elegans. It is not clear if it makes sense to try and generalize the concept and include in CL, and this term may be obsoleted in future. Note there is no similarity to the hypodermis in vertebrates. +synonym: "roundworm hypodermal cell" BROAD [] xref: WBbt:0007846 is_a: CL:0000076 ! squamous epithelial cell is_a: CL:0000228 ! multinucleate cell is_a: CL:0002371 ! somatic cell -relationship: in_taxon NCBITaxon:6157 ! Platyhelminthes +relationship: in_taxon NCBITaxon:6237 ! Caenorhabditis [Term] id: CL:0000412 @@ -31977,7 +31962,9 @@ synonym: "L5b neuron" EXACT [] synonym: "pyramidal tract (PT) neuron" EXACT [] synonym: "subcerebral projection (SCPN) neuron" EXACT [] synonym: "thick-tufted layer 5 pyramidal neuron" EXACT [] +is_a: CL:0000104 ! multipolar neuron is_a: CL:4023009 ! extratelencephalic-projecting glutamatergic cortical neuron +relationship: bearer_of PATO:0070015 ! pyramidal family morphology relationship: dc-creator http://orcid.org/0000-0001-7258-9596 [Term] @@ -44980,7 +44967,7 @@ def: "A tissue-specific, membrane-bounded cytoplasmic organelle within which mel xref: Wikipedia:Melanosome is_a: GO:0048770 ! pigment granule relationship: never_in_taxon NCBITaxon:4895 -relationship: never_in_taxon NCBITaxon:6237 +relationship: never_in_taxon NCBITaxon:6237 ! Caenorhabditis [Term] id: GO:0042475 @@ -53874,17 +53861,6 @@ is_a: GO:0140112 ! extracellular vesicle biogenesis created_by: pr creation_date: 2016-10-03T14:35:25Z -[Term] -id: GO:0098537 -name: obsolete lobed nucleus -namespace: cellular_component -def: "OBSOLETE. Nucleus with two or more lobes connected by a thin filament that contains no internal chromatin. Examples include the nuclei of mature basophils, eosinophils and neutrophils in mice and humans." [GOC:dos, GOC:tfm] -comment: This term was obsoleted because it does not correspond to a specific type of nucleus, it is a morphologically different nucleus present in certain cell types. -property_value: IAO:0000233 https://github.com/geneontology/go-ontology/issues/20764 xsd:anyURI -is_obsolete: true -created_by: dos -creation_date: 2013-10-22T18:31:36Z - [Term] id: GO:0098542 name: defense response to other organism @@ -59462,7 +59438,6 @@ name: Teleostomi namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:7776 ! Gnathostomata -property_value: has_rank NCBITaxon:clade [Term] id: NCBITaxon:117571 @@ -59472,7 +59447,16 @@ alt_id: NCBITaxon:40673 synonym: "bony vertebrates" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:117570 ! Teleostomi -property_value: has_rank NCBITaxon:clade + +[Term] +id: NCBITaxon:119089 +name: Chromadorea +namespace: ncbi_taxonomy +alt_id: NCBITaxon:27837 +synonym: "Adenophorea" RELATED synonym [] +xref: GC_ID:1 +is_a: NCBITaxon:6231 ! Nematoda +property_value: has_rank NCBITaxon:class [Term] id: NCBITaxon:1206794 @@ -59480,7 +59464,6 @@ name: Ecdysozoa namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:33317 ! Protostomia -property_value: has_rank NCBITaxon:clade [Term] id: NCBITaxon:1206795 @@ -59488,7 +59471,6 @@ name: Lophotrochozoa namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:2697495 ! Spiralia -property_value: has_rank NCBITaxon:clade [Term] id: NCBITaxon:131567 @@ -59504,7 +59486,6 @@ name: Dipnotetrapodomorpha namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:8287 ! Sarcopterygii -property_value: has_rank NCBITaxon:clade [Term] id: NCBITaxon:142796 @@ -59528,7 +59509,6 @@ xref: GC_ID:1 xref: PMID:11743200 xref: PMID:11791233 is_a: NCBITaxon:9347 ! Eutheria -property_value: has_rank NCBITaxon:clade [Term] id: NCBITaxon:1963758 @@ -59549,6 +59529,22 @@ xref: GC_ID:1 is_a: NCBITaxon:9604 ! Hominidae property_value: has_rank NCBITaxon:subfamily +[Term] +id: NCBITaxon:2301116 +name: Rhabditina +namespace: ncbi_taxonomy +xref: GC_ID:1 +is_a: NCBITaxon:6236 ! Rhabditida +property_value: has_rank NCBITaxon:suborder + +[Term] +id: NCBITaxon:2301119 +name: Rhabditomorpha +namespace: ncbi_taxonomy +xref: GC_ID:1 +is_a: NCBITaxon:2301116 ! Rhabditina +property_value: has_rank NCBITaxon:infraorder + [Term] id: NCBITaxon:2605435 name: Evosea @@ -59563,7 +59559,6 @@ name: Spiralia namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:33317 ! Protostomia -property_value: has_rank NCBITaxon:clade [Term] id: NCBITaxon:2759 @@ -59617,7 +59612,6 @@ xref: PMID:11214319 xref: PMID:12082125 xref: PMID:15522813 is_a: NCBITaxon:314146 ! Euarchontoglires -property_value: has_rank NCBITaxon:clade [Term] id: NCBITaxon:314293 @@ -59645,7 +59639,6 @@ namespace: ncbi_taxonomy synonym: "tetrapods" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:1338369 ! Dipnotetrapodomorpha -property_value: has_rank NCBITaxon:clade [Term] id: NCBITaxon:32524 @@ -59654,7 +59647,6 @@ namespace: ncbi_taxonomy synonym: "amniotes" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:32523 ! Tetrapoda -property_value: has_rank NCBITaxon:clade [Term] id: NCBITaxon:32525 @@ -59663,7 +59655,6 @@ namespace: ncbi_taxonomy synonym: "Theria" EXACT scientific_name [] xref: GC_ID:1 is_a: NCBITaxon:40674 ! Mammalia -property_value: has_rank NCBITaxon:clade [Term] id: NCBITaxon:33154 @@ -59673,7 +59664,6 @@ synonym: "Fungi/Metazoa group" RELATED synonym [] synonym: "opisthokonts" RELATED synonym [] xref: GC_ID:1 is_a: NCBITaxon:2759 ! Eukaryota -property_value: has_rank NCBITaxon:clade [Term] id: NCBITaxon:33208 @@ -59694,7 +59684,6 @@ name: Bilateria namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:6072 ! Eumetazoa -property_value: has_rank NCBITaxon:clade [Term] id: NCBITaxon:33317 @@ -59702,7 +59691,6 @@ name: Protostomia namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:33213 ! Bilateria -property_value: has_rank NCBITaxon:clade [Term] id: NCBITaxon:33511 @@ -59711,7 +59699,6 @@ namespace: ncbi_taxonomy synonym: "deuterostomes" EXACT common_name [] xref: GC_ID:1 is_a: NCBITaxon:33213 ! Bilateria -property_value: has_rank NCBITaxon:clade [Term] id: NCBITaxon:33554 @@ -59731,7 +59718,6 @@ xref: GC_ID:1 xref: PMID:15019624 xref: PMID:15371245 is_a: NCBITaxon:1963758 ! Myomorpha -property_value: has_rank NCBITaxon:clade [Term] id: NCBITaxon:338152 @@ -59800,7 +59786,22 @@ xref: GC_ID:1 xref: PMID:23020233 xref: PMID:30257078 is_a: NCBITaxon:2759 ! Eukaryota -property_value: has_rank NCBITaxon:clade + +[Term] +id: NCBITaxon:55879 +name: Rhabditoidea +namespace: ncbi_taxonomy +xref: GC_ID:1 +is_a: NCBITaxon:2301119 ! Rhabditomorpha +property_value: has_rank NCBITaxon:superfamily + +[Term] +id: NCBITaxon:55885 +name: Peloderinae +namespace: ncbi_taxonomy +xref: GC_ID:1 +is_a: NCBITaxon:6243 ! Rhabditidae +property_value: has_rank NCBITaxon:subfamily [Term] id: NCBITaxon:6072 @@ -59808,7 +59809,6 @@ name: Eumetazoa namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:33208 ! Metazoa -property_value: has_rank NCBITaxon:clade [Term] id: NCBITaxon:6157 @@ -59821,6 +59821,46 @@ xref: GC_ID:1 is_a: NCBITaxon:1206795 ! Lophotrochozoa property_value: has_rank NCBITaxon:phylum +[Term] +id: NCBITaxon:6231 +name: Nematoda +namespace: ncbi_taxonomy +synonym: "Nemata" RELATED synonym [] +synonym: "nematode" EXACT common_name [] +synonym: "nematodes" EXACT common_name [] +synonym: "nematodes" RELATED blast_name [] +synonym: "roundworm" EXACT common_name [] +synonym: "roundworms" EXACT genbank_common_name [] +xref: GC_ID:1 +is_a: NCBITaxon:1206794 ! Ecdysozoa +property_value: has_rank NCBITaxon:phylum + +[Term] +id: NCBITaxon:6236 +name: Rhabditida +namespace: ncbi_taxonomy +alt_id: NCBITaxon:33251 +xref: GC_ID:1 +is_a: NCBITaxon:119089 ! Chromadorea +property_value: has_rank NCBITaxon:order + +[Term] +id: NCBITaxon:6237 +name: Caenorhabditis +namespace: ncbi_taxonomy +xref: GC_ID:1 +is_a: NCBITaxon:55885 ! Peloderinae +property_value: has_rank NCBITaxon:genus + +[Term] +id: NCBITaxon:6243 +name: Rhabditidae +namespace: ncbi_taxonomy +alt_id: NCBITaxon:54603 +xref: GC_ID:1 +is_a: NCBITaxon:55879 ! Rhabditoidea +property_value: has_rank NCBITaxon:family + [Term] id: NCBITaxon:6656 name: Arthropoda @@ -59850,7 +59890,6 @@ synonym: "vertebrates" EXACT genbank_common_name [] synonym: "vertebrates" RELATED blast_name [] xref: GC_ID:1 is_a: NCBITaxon:89593 ! Craniata -property_value: has_rank NCBITaxon:clade [Term] id: NCBITaxon:7776 @@ -59860,7 +59899,6 @@ synonym: "Gnathostomata" EXACT scientific_name [] synonym: "jawed vertebrates" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:7742 ! Vertebrata -property_value: has_rank NCBITaxon:clade [Term] id: NCBITaxon:8287 @@ -59885,7 +59923,6 @@ name: Panarthropoda namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:1206794 ! Ecdysozoa -property_value: has_rank NCBITaxon:clade [Term] id: NCBITaxon:89593 @@ -59907,7 +59944,6 @@ synonym: "placentals" EXACT genbank_common_name [] synonym: "placentals" RELATED blast_name [] xref: GC_ID:1 is_a: NCBITaxon:32525 ! Theria -property_value: has_rank NCBITaxon:clade [Term] id: NCBITaxon:9443 @@ -60511,6 +60547,15 @@ comment: This quality either inheres directly in the surface, or in the entity t subset: attribute_slim is_a: PATO:0000052 ! shape +[Term] +id: PATO:0001979 +name: lobed +namespace: quality +def: "A shape quality inhering in a bearer by virtue of the bearer's being partly divided into a determinate number of regions." [ISBN:0881923214] +subset: mpath_slim +subset: value_slim +is_a: PATO:0000052 ! shape + [Term] id: PATO:0001992 name: cellularity @@ -82216,8 +82261,8 @@ def: "external genital organs of the female mammal[WP]." [http://en.wikipedia.or subset: efo_slim subset: pheno_slim subset: uberon_slim -synonym: "female pudendum" EXACT [FMA:20462] synonym: "female pudendum" EXACT [BTO:0003101] +synonym: "female pudendum" EXACT [FMA:20462] synonym: "mammalian vulva" EXACT [] synonym: "puboperineal region" EXACT [FMA:20462] synonym: "pudendum" RELATED [BTO:0003101] @@ -105084,8 +105129,8 @@ xref: EV:0100173 xref: FMA:77624 xref: GAID:633 xref: HBA:9303 -xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=279 {source="BIRNLEX:1137"} xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=279 +xref: http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=279 {source="BIRNLEX:1137"} xref: http://linkedlifedata.com/resource/umls/id/C0028936 xref: http://www.snomedbrowser.com/Codes/Details/279394006 xref: MA:0000194 @@ -169129,14 +169174,20 @@ property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl [Typedef] id: RO:0000052 +name: characteristic of name: inheres in +def: "a relation between a specifically dependent continuant (the characteristic) and any other entity (the bearer), in which the characteristic depends on the bearer for its existence." [] def: "a relation between a specifically dependent continuant (the dependent) and an independent continuant (the bearer), in which the dependent specifically depends on the bearer for its existence" [] +comment: Note that this relation was previously called "inheres in", but was changed to be called "characteristic of" because BFO2 uses "inheres in" in a more restricted fashion. This relation differs from BFO2:inheres_in in two respects: (1) it does not impose a range constraint, and thus it allows qualities of processes, as well as of information entities, whereas BFO2 restricts inheres_in to only apply to independent continuants (2) it is declared functional, i.e. something can only be a characteristic of one thing. property_value: editor_note "A dependent inheres in its bearer at all times for which the dependent exists." xsd:string property_value: IAO:0000111 "inheres in" xsd:string property_value: IAO:0000112 "this fragility inheres in this vase" xsd:string +property_value: IAO:0000112 "this fragility is a characteristic of this vase" xsd:string property_value: IAO:0000112 "this red color inheres in this apple" xsd:string +property_value: IAO:0000112 "this red color is a characteristic of this apple" xsd:string property_value: IAO:0000118 "inheres_in" xsd:string property_value: RO:0001900 RO:0001901 +is_functional: true is_a: RO:0002314 ! inheres in part of inverse_of: bearer_of ! bearer of @@ -169155,6 +169206,71 @@ domain: BFO:0000003 ! occurrent range: BFO:0000002 ! continuant holds_over_chain: has_part RO:0000057 +[Typedef] +id: RO:0000079 +name: function of +def: "a relation between a function and an independent continuant (the bearer), in which the function specifically depends on the bearer for its existence" [] +comment: This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020. +property_value: editor_note "A function inheres in its bearer at all times for which the function exists, however the function need not be realized at all the times that the function exists." xsd:string +property_value: IAO:0000112 "this catalysis function is a function of this enzyme" xsd:string +property_value: IAO:0000118 "function_of" xsd:string +property_value: IAO:0000118 "is function of" xsd:string +domain: BFO:0000034 ! function +is_a: RO:0000052 ! inheres in +inverse_of: RO:0000085 ! has function + +[Typedef] +id: RO:0000080 +name: quality of +def: "a relation between a quality and an independent continuant (the bearer), in which the quality specifically depends on the bearer for its existence" [] +comment: This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020. +property_value: editor_note "A quality inheres in its bearer at all times for which the quality exists." xsd:string +property_value: IAO:0000112 "this red color is a quality of this apple" xsd:string +property_value: IAO:0000118 "is quality of" xsd:string +property_value: IAO:0000118 "quality_of" xsd:string +is_a: RO:0000052 ! inheres in +inverse_of: has_quality ! has quality + +[Typedef] +id: RO:0000081 +name: role of +def: "a relation between a role and an independent continuant (the bearer), in which the role specifically depends on the bearer for its existence" [] +comment: This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020. +property_value: editor_note "A role inheres in its bearer at all times for which the role exists, however the role need not be realized at all the times that the role exists." xsd:string +property_value: IAO:0000112 "this investigator role is a role of this person" xsd:string +property_value: IAO:0000118 "is role of" xsd:string +property_value: IAO:0000118 "role_of" xsd:string +is_a: RO:0000052 ! inheres in +inverse_of: has_role ! has role + +[Typedef] +id: RO:0000085 +name: has function +def: "a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence" [] +property_value: editor_note "A bearer can have many functions, and its functions can exist for different periods of time, but none of its functions can exist when the bearer does not exist. A function need not be realized at all the times that the function exists." xsd:string +property_value: IAO:0000112 "this enzyme has function this catalysis function (more colloquially: this enzyme has this catalysis function)" xsd:string +property_value: IAO:0000118 "has_function" xsd:string +domain: BFO:0000004 ! independent continuant +range: BFO:0000034 ! function +is_a: bearer_of ! bearer of + +[Typedef] +id: RO:0000091 +name: has disposition +def: "a relation between an independent continuant (the bearer) and a disposition, in which the disposition specifically depends on the bearer for its existence" [] +domain: BFO:0000004 ! independent continuant +range: BFO:0000016 ! disposition +is_a: bearer_of ! bearer of +inverse_of: RO:0000092 ! disposition of + +[Typedef] +id: RO:0000092 +name: disposition of +def: "inverse of has disposition" [] +comment: This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020. +subset: RO:0002259 +is_a: RO:0000052 ! inheres in + [Typedef] id: RO:0001001 name: derives into @@ -169184,6 +169300,7 @@ inverse_of: contains ! contains [Typedef] id: RO:0002006 name: has synaptic terminal of +property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.nih.gov/pubmed/22402613 property_value: IAO:0000117 "David Osumi-Sutherland" xsd:string is_a: RO:0002131 ! overlaps inverse_of: RO:0002130 ! has synaptic terminal in @@ -169455,12 +169572,12 @@ name: spatially disjoint from def: "A is spatially_disjoint_from B if and only if they have no parts in common" [] subset: ro-eco property_value: editor_note "There are two ways to encode this as a shortcut relation. The other possibility to use an annotation assertion between two classes, and expand this to a disjointness axiom. " xsd:string -property_value: http://xmlns.com/foaf/0.1/page https://github.com/obophenotype/uberon/wiki/Part-disjointness-Design-Pattern xsd:anyURI property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/22293552 property_value: IAO:0000232 "Note that it would be possible to use the relation to label the relationship between a near infinite number of structures - between the rings of saturn and my left earlobe. The intent is that this is used for parsiomoniously for disambiguation purposes - for example, between siblings in a jointly exhaustive pairwise disjointness hierarchy" xsd:string property_value: RO:0001900 RO:0001901 +property_value: seeAlso https://github.com/obophenotype/uberon/wiki/Part-disjointness-Design-Pattern xsd:anyURI is_a: RO:0002323 ! mereotopologically related to expand_expression_to: "BFO_0000051 exactly 0 (BFO_0000050 some ?Y)" [] @@ -169578,13 +169695,18 @@ is_a: RO:0004046 ! causally upstream of or within, negative effect [Typedef] id: RO:0002314 +name: characteristic of part of name: inheres in part of +def: "q characteristic of part of w if and only if there exists some p such that q inheres in p and p part of w." [] def: "q inheres in part of w if and only if there exists some p such that q inheres in p and p part of w." [] +property_value: editor_note "Because part_of is transitive, inheres in is a sub-relation of characteristic of part of" xsd:string property_value: editor_note "Because part_of is transitive, inheres in is a sub-relation of inheres in part of" xsd:string property_value: IAO:0000117 "Chris Mungall" xsd:string +property_value: IAO:0000118 "inheres in part of" xsd:string property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/20064205 property_value: RO:0001900 RO:0001901 property_value: seeAlso "defining-property-chains-involving-reflexivity" +property_value: seeAlso http://purl.obolibrary.org/obo/ro/docs/reflexivity/ holds_over_chain: RO:0000052 part_of {http://purl.obolibrary.org/obo/RO_0002582="true"} is_a: RO:0002502 ! depends on transitive_over: part_of ! part_of @@ -169856,12 +169978,14 @@ name: interacts with def: "A relationship that holds between two entities in which the processes executed by the two entities are causally connected." [] subset: ro-eco synonym: "in pairwise interaction with" EXACT [] +property_value: closeMatch http://purl.obolibrary.org/obo/MI_0914 xsd:anyURI property_value: editor_note "Considering relabeling as 'pairwise interacts with'" xsd:anyURI property_value: editor_note "This relation and all sub-relations can be applied to either (1) pairs of entities that are interacting at any moment of time (2) populations or species of entity whose members have the disposition to interact (3) classes whose members have the disposition to interact." xsd:string property_value: http://xmlns.com/foaf/0.1/page https://github.com/oborel/obo-relations/wiki/InteractionRelations xsd:anyURI property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000232 "Note that this relationship type, and sub-relationship types may be redundant with process terms from other ontologies. For example, the symbiotic relationship hierarchy parallels GO. The relations are provided as a convenient shortcut. Consider using the more expressive processual form to capture your data. In the future, these relations will be linked to their cognate processes through rules." xsd:string property_value: seeAlso http://purl.obolibrary.org/obo/MI_0914 xsd:anyURI +property_value: seeAlso http://purl.obolibrary.org/obo/ro/docs/interaction-relations/ xsd:anyURI domain: BFO:0000040 ! material entity range: BFO:0000040 ! material entity is_symmetric: true @@ -169870,6 +169994,7 @@ is_symmetric: true id: RO:0002436 name: molecularly interacts with def: "An interaction relationship in which the two partners are molecular entities that directly physically interact with each other for example via a stable binding interaction or a brief interaction during which one modifies the other." [] +property_value: closeMatch http://purl.obolibrary.org/obo/MI_0915 xsd:anyURI property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000118 "binds" xsd:string property_value: IAO:0000118 "molecularly binds with" xsd:string @@ -170010,6 +170135,7 @@ name: interaction relation helper property property_value: http://xmlns.com/foaf/0.1/page https://github.com/oborel/obo-relations/wiki/InteractionRelations xsd:anyURI property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: seeAlso http://ontologydesignpatterns.org/wiki/Submissions:N-Ary_Relation_Pattern_%28OWL_2%29 +property_value: seeAlso http://purl.obolibrary.org/obo/ro/docs/interaction-relations/ xsd:anyURI is_a: RO:0002464 ! helper property (not for use in curation) [Typedef] @@ -170288,8 +170414,10 @@ equivalent_to_chain: attaches_to part_of ! part_of [Typedef] id: bearer_of name: bearer of +name: has characteristic namespace: uberon def: "a relation between an independent continuant (the bearer) and a specifically dependent continuant (the dependent), in which the dependent specifically depends on the bearer for its existence" [] +def: "Inverse of characteristic_of" [] xref: RO:0000053 property_value: editor_note "A bearer can have many dependents, and its dependents can exist for different periods of time, but none of its dependents can exist when the bearer does not exist." xsd:string property_value: IAO:0000111 "bearer of" xsd:string @@ -170299,6 +170427,7 @@ property_value: IAO:0000118 "bearer_of" xsd:string property_value: IAO:0000118 "is bearer of" xsd:string property_value: RO:0001900 RO:0001901 range: BFO:0000020 ! specifically dependent continuant +is_inverse_functional: true [Typedef] id: bounding_layer_of @@ -170349,6 +170478,7 @@ xref: RO:0002216 property_value: IAO:0000117 "Chris Mungall" xsd:string property_value: IAO:0000118 "has function in" xsd:string property_value: seeAlso "defining-property-chains-involving-reflexivity" +property_value: seeAlso http://purl.obolibrary.org/obo/ro/docs/reflexivity/ holds_over_chain: capable_of part_of {http://purl.obolibrary.org/obo/RO_0002582="true"} is_a: functionally_related_to ! functionally related to is_a: RO:0002500 ! causal agent in process @@ -170395,10 +170525,10 @@ def: "a is connected to b if and only if a and b are discrete structure, and the def: "Binary relationship: x connected_to y if and only if there exists some z such that z connects x and y in a ternary connected_to(x,y,z) relationship." [http://purl.obolibrary.org/obo/uberon/docs/Connectivity-Design-Pattern] comment: Connection does not imply overlaps. xref: RO:0002170 -property_value: http://xmlns.com/foaf/0.1/page https://github.com/obophenotype/uberon/wiki/Connectivity-Design-Pattern xsd:anyURI -property_value: http://xmlns.com/foaf/0.1/page https://github.com/obophenotype/uberon/wiki/Modeling-articulations-Design-Pattern xsd:anyURI property_value: IAO:0000112 "a 'toe distal phalanx bone' that is connected to a 'toe medial phalanx bone' (an interphalangeal joint *connects* these two bones)." xsd:string property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/22293552 +property_value: seeAlso https://github.com/obophenotype/uberon/wiki/Connectivity-Design-Pattern xsd:anyURI +property_value: seeAlso https://github.com/obophenotype/uberon/wiki/Modeling-articulations-Design-Pattern xsd:anyURI property_value: seeAlso SIO:000652 is_a: RO:0002323 ! mereotopologically related to is_a: transitively_connected_to ! transitively_connected to @@ -170893,6 +171023,7 @@ subset: http://purl.obolibrary.org/obo/valid_for_go_ontology subset: http://purl.obolibrary.org/obo/valid_for_gocam xref: BFO:0000051 property_value: editor_note "Everything has itself as a part. Any part of any part of a thing is itself part of that thing. Two distinct things cannot have each other as a part." xsd:string +property_value: editor_note "Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/" xsd:string property_value: editor_note "Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime" xsd:string property_value: editor_note "Parthood requires the part and the whole to have compatible classes: only an occurrent have an occurrent as part; only a process can have a process as part; only a continuant can have a continuant as part; only an independent continuant can have an independent continuant as part; only a specifically dependent continuant can have a specifically dependent continuant as part; only a generically dependent continuant can have a generically dependent continuant as part. (This list is not exhaustive.)\n\nA continuant cannot have an occurrent as part: use 'participates in'. An occurrent cannot have a continuant as part: use 'has participant'. An immaterial entity cannot have a material entity as part: use 'location of'. An independent continuant cannot have a specifically dependent continuant as part: use 'bearer of'. A specifically dependent continuant cannot have an independent continuant as part: use 'inheres in'." xsd:string property_value: IAO:0000111 "has part" xsd:string @@ -170927,10 +171058,17 @@ is_a: RO:0002384 ! has developmental potential involving [Typedef] id: has_quality +name: has quality name: has_quality namespace: protein +def: "a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence" [] xref: RO:0000086 +property_value: editor_note "A bearer can have many qualities, and its qualities can exist for different periods of time, but none of its qualities can exist when the bearer does not exist." xsd:string +property_value: IAO:0000112 "this apple has quality this red color" xsd:string +property_value: IAO:0000118 "has_quality" xsd:string +range: BFO:0000019 ! quality is_transitive: false +is_a: bearer_of ! bearer of [Typedef] id: has_relative_magnitude @@ -170941,9 +171079,16 @@ namespace: quality id: has_role name: has role namespace: chebi_ontology +def: "a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence" [] xref: RO:0000087 +property_value: editor_note "A bearer can have many roles, and its roles can exist for different periods of time, but none of its roles can exist when the bearer does not exist. A role need not be realized at all the times that the role exists." xsd:string +property_value: IAO:0000112 "this person has role this investigator role (more colloquially: this person has this role of investigator)" xsd:string +property_value: IAO:0000118 "has_role" xsd:string +domain: BFO:0000004 ! independent continuant +range: BFO:0000023 ! role is_cyclic: false is_transitive: false +is_a: bearer_of ! bearer of [Typedef] id: has_skeleton @@ -171205,7 +171350,7 @@ def: "a relation between two independent continuants, the target and the locatio subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term xref: RO:0001025 property_value: editor_note "Location as a relation between instances: The primitive instance-level relation c located_in r at t reflects the fact that each continuant is at any given time associated with exactly one spatial region, namely its exact location. Following we can use this relation to define a further instance-level location relation - not between a continuant and the region which it exactly occupies, but rather between one continuant and another. c is located in c1, in this sense, whenever the spatial region occupied by c is part_of the spatial region occupied by c1. Note that this relation comprehends both the relation of exact location between one continuant and another which obtains when r and r1 are identical (for example, when a portion of fluid exactly fills a cavity), as well as those sorts of inexact location relations which obtain, for example, between brain and head or between ovum and uterus" xsd:string -property_value: editor_note "Most location relations will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime" xsd:string +property_value: editor_note "Most location relations will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/" xsd:string property_value: http://purl.org/dc/elements/1.1/source http://www.obofoundry.org/ro/#OBO_REL:located_in xsd:string property_value: IAO:0000111 "located in" xsd:string property_value: IAO:0000112 "my brain is located in my head" xsd:string @@ -171224,7 +171369,7 @@ name: location_of namespace: uberon def: "a relation between two independent continuants, the location and the target, in which the target is entirely within the location" [] xref: RO:0001015 -property_value: editor_note "Most location relations will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime" xsd:string +property_value: editor_note "Most location relations will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/" xsd:string property_value: IAO:0000111 "is location of" xsd:string property_value: IAO:0000112 "my head is the location of my brain" xsd:string property_value: IAO:0000112 "this cage is the location of this rat" xsd:string @@ -171357,6 +171502,7 @@ subset: http://purl.obolibrary.org/obo/valid_for_go_ontology subset: http://purl.obolibrary.org/obo/valid_for_gocam xref: BFO:0000050 property_value: editor_note "Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other." xsd:string +property_value: editor_note "Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/" xsd:string property_value: editor_note "Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime" xsd:string property_value: editor_note "Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.)\n\nA continuant cannot be part of an occurrent: use 'participates in'. An occurrent cannot be part of a continuant: use 'has participant'. A material entity cannot be part of an immaterial entity: use 'has location'. A specifically dependent continuant cannot be part of an independent continuant: use 'inheres in'. An independent continuant cannot be part of a specifically dependent continuant: use 'bearer of'." xsd:string property_value: IAO:0000111 "is part of" xsd:string diff --git a/cl.owl b/cl.owl index 5785c12ed..defb8de68 100644 --- a/cl.owl +++ b/cl.owl @@ -14,6 +14,7 @@ xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:pato="http://purl.obolibrary.org/obo/pato#" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" + xmlns:skos="http://www.w3.org/2004/02/skos/core#" xmlns:swrl="http://www.w3.org/2003/11/swrl#" xmlns:chebi="http://purl.obolibrary.org/obo/chebi/" xmlns:core1="http://purl.obolibrary.org/obo/core#" @@ -25,11 +26,11 @@ xmlns:uberon="http://purl.obolibrary.org/obo/uberon#" xmlns:ubprop="http://purl.obolibrary.org/obo/ubprop#" xmlns:subsets="http://purl.obolibrary.org/obo/ro/subsets#" + xmlns:taxslim="http://purl.obolibrary.org/obo/ncbitaxon/subsets/taxslim#" xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#" - xmlns:ncbitaxon="http://purl.obolibrary.org/obo/ncbitaxon#" xmlns:oboInOwl2="http://geneontology.org/formats/oboInOwl#"> - + Alexander Diehl Ceri van Slyke @@ -44,7 +45,7 @@ Cell Ontology See PMID:15693950, PMID:12799354, PMID:20123131, PMID:21208450; Contact Alexander Diehl, addiehl@buffalo.edu, University at Buffalo. - 2021-06-21 + 2021-06-28 @@ -665,9 +666,9 @@ - + - + @@ -1424,6 +1425,12 @@ + + + + + + @@ -1466,6 +1473,7 @@ this day is part of this year (occurrent parthood) a core relation that holds between a part and its whole Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other. + Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/ Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.) @@ -1512,6 +1520,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Q1 has_part Q2 if and only if: every instance of Q1 is a quality_of an entity that has_quality some Q2. a core relation that holds between a whole and its part Everything has itself as a part. Any part of any part of a thing is itself part of that thing. Two distinct things cannot have each other as a part. + Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/ Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime Parthood requires the part and the whole to have compatible classes: only an occurrent have an occurrent as part; only a process can have a process as part; only a continuant can have a continuant as part; only an independent continuant can have an independent continuant as part; only a specifically dependent continuant can have a specifically dependent continuant as part; only a generically dependent continuant can have a generically dependent continuant as part. (This list is not exhaustive.) @@ -2103,13 +2112,19 @@ A continuant cannot have an occurrent as part: use 'participates in'. + inheres in this fragility inheres in this vase + this fragility is a characteristic of this vase this red color inheres in this apple + this red color is a characteristic of this apple + a relation between a specifically dependent continuant (the characteristic) and any other entity (the bearer), in which the characteristic depends on the bearer for its existence. a relation between a specifically dependent continuant (the dependent) and an independent continuant (the bearer), in which the dependent specifically depends on the bearer for its existence A dependent inheres in its bearer at all times for which the dependent exists. inheres_in + Note that this relation was previously called "inheres in", but was changed to be called "characteristic of" because BFO2 uses "inheres in" in a more restricted fashion. This relation differs from BFO2:inheres_in in two respects: (1) it does not impose a range constraint, and thus it allows qualities of processes, as well as of information entities, whereas BFO2 restricts inheres_in to only apply to independent continuants (2) it is declared functional, i.e. something can only be a characteristic of one thing. + characteristic of inheres in @@ -2118,10 +2133,12 @@ A continuant cannot have an occurrent as part: use 'participates in'. + bearer of this apple is bearer of this red color this vase is bearer of this fragility + Inverse of characteristic_of a relation between an independent continuant (the bearer) and a specifically dependent continuant (the dependent), in which the dependent specifically depends on the bearer for its existence A bearer can have many dependents, and its dependents can exist for different periods of time, but none of its dependents can exist when the bearer does not exist. bearer_of @@ -2133,6 +2150,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. bearer_of bearer of bearer of + has characteristic @@ -2184,14 +2202,85 @@ A continuant cannot have an occurrent as part: use 'participates in'. + + + + + + + this catalysis function is a function of this enzyme + a relation between a function and an independent continuant (the bearer), in which the function specifically depends on the bearer for its existence + A function inheres in its bearer at all times for which the function exists, however the function need not be realized at all the times that the function exists. + function_of + is function of + This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020. + function of + + + + + + + + + + this red color is a quality of this apple + a relation between a quality and an independent continuant (the bearer), in which the quality specifically depends on the bearer for its existence + A quality inheres in its bearer at all times for which the quality exists. + is quality of + quality_of + This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020. + quality of + + + + + + + + + + this investigator role is a role of this person + a relation between a role and an independent continuant (the bearer), in which the role specifically depends on the bearer for its existence + A role inheres in its bearer at all times for which the role exists, however the role need not be realized at all the times that the role exists. + is role of + role_of + This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020. + role of + + + + + + + + + + + this enzyme has function this catalysis function (more colloquially: this enzyme has this catalysis function) + a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence + A bearer can have many functions, and its functions can exist for different periods of time, but none of its functions can exist when the bearer does not exist. A function need not be realized at all the times that the function exists. + has_function + has function + + + + + + + this apple has quality this red color + a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence + A bearer can have many qualities, and its qualities can exist for different periods of time, but none of its qualities can exist when the bearer does not exist. + has_quality RO:0000086 protein has_quality false has_quality + has quality has_quality @@ -2200,6 +2289,13 @@ A continuant cannot have an occurrent as part: use 'participates in'. + + + + this person has role this investigator role (more colloquially: this person has this role of investigator) + a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence + A bearer can have many roles, and its roles can exist for different periods of time, but none of its roles can exist when the bearer does not exist. A role need not be realized at all the times that the role exists. + has_role RO:0000087 chebi_ontology has_role @@ -2207,6 +2303,32 @@ A continuant cannot have an occurrent as part: use 'participates in'. false has_role has role + has role + + + + + + + + + + + + a relation between an independent continuant (the bearer) and a disposition, in which the disposition specifically depends on the bearer for its existence + has disposition + + + + + + + + + inverse of has disposition + + This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020. + disposition of @@ -2258,7 +2380,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. my head is the location of my brain this cage is the location of this rat a relation between two independent continuants, the location and the target, in which the target is entirely within the location - Most location relations will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime + Most location relations will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/ location_of RO:0001015 @@ -2347,7 +2469,7 @@ range: spatial region or site (immaterial continuant) this rat is located in this cage a relation between two independent continuants, the target and the location, in which the target is entirely within the location Location as a relation between instances: The primitive instance-level relation c located_in r at t reflects the fact that each continuant is at any given time associated with exactly one spatial region, namely its exact location. Following we can use this relation to define a further instance-level location relation - not between a continuant and the region which it exactly occupies, but rather between one continuant and another. c is located in c1, in this sense, whenever the spatial region occupied by c is part_of the spatial region occupied by c1. Note that this relation comprehends both the relation of exact location between one continuant and another which obtains when r and r1 are identical (for example, when a portion of fluid exactly fills a cavity), as well as those sorts of inexact location relations which obtain, for example, between brain and head or between ovum and uterus - Most location relations will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime + Most location relations will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/ located_in http://www.obofoundry.org/ro/#OBO_REL:located_in @@ -2425,6 +2547,7 @@ range: spatial region or site (immaterial continuant) David Osumi-Sutherland + has synaptic terminal of @@ -3188,7 +3311,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. spatially disjoint from - https://github.com/obophenotype/uberon/wiki/Part-disjointness-Design-Pattern + https://github.com/obophenotype/uberon/wiki/Part-disjointness-Design-Pattern @@ -3222,8 +3345,8 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.connected to connected to - https://github.com/obophenotype/uberon/wiki/Connectivity-Design-Pattern - https://github.com/obophenotype/uberon/wiki/Modeling-articulations-Design-Pattern + https://github.com/obophenotype/uberon/wiki/Connectivity-Design-Pattern + https://github.com/obophenotype/uberon/wiki/Modeling-articulations-Design-Pattern @@ -3581,6 +3704,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.capable_of_part_of capable of part of capable of part of + @@ -4007,12 +4131,17 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. + q characteristic of part of w if and only if there exists some p such that q inheres in p and p part of w. q inheres in part of w if and only if there exists some p such that q inheres in p and p part of w. + Because part_of is transitive, inheres in is a sub-relation of characteristic of part of Because part_of is transitive, inheres in is a sub-relation of inheres in part of Chris Mungall + inheres in part of + characteristic of part of inheres in part of + @@ -4705,6 +4834,8 @@ Each of these 3 primitives can be composed to yield a cross-product of different interacts with http://purl.obolibrary.org/obo/MI_0914 + http://purl.obolibrary.org/obo/ro/docs/interaction-relations/ + http://purl.obolibrary.org/obo/MI_0914 https://github.com/oborel/obo-relations/wiki/InteractionRelations @@ -4722,6 +4853,7 @@ Each of these 3 primitives can be composed to yield a cross-product of different molecularly interacts with http://purl.obolibrary.org/obo/MI_0915 + http://purl.obolibrary.org/obo/MI_0915 @@ -5190,6 +5322,7 @@ For example, A and B may be gene products and binding of B by A positively regul Chris Mungall interaction relation helper property + http://purl.obolibrary.org/obo/ro/docs/interaction-relations/ https://github.com/oborel/obo-relations/wiki/InteractionRelations @@ -6224,6 +6357,33 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + + disposition + + + + + + + + + + + + + + + + A specifically dependent continuant that inheres in continuant entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances. + realizable entity + + + + @@ -6259,6 +6419,16 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + A realizable entity the manifestation of which brings about some result or end that is not essential to a continuant in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant in some kinds of natural, social or institutional contexts. + role + + + + @@ -6297,6 +6467,15 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + function + + + + @@ -8016,7 +8195,7 @@ For example, A and B may be gene products and binding of B by A positively regul protein residue - PRO:DAN + PRO:DAN @@ -8852,7 +9031,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A cell found in the embryo before the formation of all the gem layers is complete. - GOC:tfm + GOC:tfm @@ -9094,7 +9273,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A male germ cell that develops from spermatogonia. The euploid primary spermatocytes undergo meiosis and give rise to the haploid secondary spermatocytes which in turn give rise to spermatids. - GOC:tfm + GOC:tfm MESH:A05.360.490.890.880 @@ -9211,7 +9390,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A mature male germ cell that develops from a spermatid. - GOC:tfm + GOC:tfm MESH:A05.360.490.890 @@ -9304,7 +9483,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u Female germ cell is a germ cell that supports female gamete production. - GOC:tfm + GOC:tfm PMID:11023867 PMID:20454446 @@ -9376,7 +9555,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A female germ cell that has entered meiosis. - GOC:tfm + GOC:tfm ISBN:0721662544 @@ -9424,7 +9603,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u An undifferentiated germ cell that proliferates rapidly and gives rise to oocytes. - GOC:tfm + GOC:tfm ISBN:0721662544 @@ -9468,7 +9647,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A female gamete where meiosis has progressed to metaphase II and is able to participate in fertilization. - GOC:tfm + GOC:tfm ISBN:0721662544 @@ -9496,7 +9675,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A germline cell that contributes to the development of the oocyte by transferring cytoplasm directly to oocyte. - GOC:tfm + GOC:tfm PMID:15848391 @@ -9662,7 +9841,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A cell of a platelike structure, especially a thickened plate of ectoderm in the early embryo, from which a sense organ develops. - GOC:tfm + GOC:tfm ISBN:0618947256 @@ -9680,7 +9859,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u An apocrine cell is a secretory cell characterized loss of part of the cytoplasm during the process of secretion - secretions are budded off through the plasma membrane producing membrane bound vesicles containing the secreted substance. - GOC:tfm + GOC:tfm ISBN:0721662544 @@ -9717,7 +9896,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. - GOC:tfm + GOC:tfm MESH:A11.872 @@ -9759,7 +9938,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A stem cell that self-renews as well as give rise to a single mature cell type. - GOC:tfm + GOC:tfm @@ -9947,7 +10126,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119. GOC:add GOC:dsd - GOC:tfm + GOC:tfm PMID:19022770 http://en.wikipedia.org/wiki/Hematopoietic_stem_cell @@ -10013,7 +10192,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring. - GOC:tfm + GOC:tfm ISBN:0721662544 @@ -10117,10 +10296,6 @@ Covers cells actively being cultured or stored in a quiescent state for future u - - - - @@ -10145,6 +10320,20 @@ Covers cells actively being cultured or stored in a quiescent state for future u + + + + + + + + + + + + + + @@ -10166,12 +10355,6 @@ Covers cells actively being cultured or stored in a quiescent state for future u - - - - - - @@ -10208,6 +10391,22 @@ Covers cells actively being cultured or stored in a quiescent state for future u + + + + + + + + + + + + + + + + @@ -10261,7 +10460,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A fully differentiated eosinophil, a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Cells are also differentiated from other granulocytes by a small nuclear-to-cytoplasm ratio (1:3). This cell type is CD49d-positive. GOC:add GOC:dsd - GOC:tfm + GOC:tfm ISBN:0721601464 http://www.cap.org @@ -10373,7 +10572,17 @@ Covers cells actively being cultured or stored in a quiescent state for future u - + + + + + + + + + + + @@ -10411,7 +10620,17 @@ Covers cells actively being cultured or stored in a quiescent state for future u - + + + + + + + + + + + @@ -10480,7 +10699,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A fully differentiated basophil, a granular leukocyte with an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation. GOC:add GOC:dsd - GOC:tfm + GOC:tfm ISBN:0721601464 PMID:18466030 PMID:19231594 @@ -10560,7 +10779,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u Neural stem cell is characterized as an undifferentiated cell that originates from the neuroectoderm and has the capacity both to perpetually self-renew without differentiating and to generate multiple types of lineage-restricted progenitors. - GOC:tfm + GOC:tfm MESH:D058953 PMID:15247488 http://en.wikipedia.org/wiki/Neural_stem_cell @@ -10751,7 +10970,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A progenitor cell committed to the megakaryocyte and erythroid lineages. GOC:add GOC:dsd - GOC:tfm + GOC:tfm MESH:D055015 PMID:16647566 http://en.wikipedia.org/wiki/Megakaryocyte-erythroid_progenitor_cell @@ -10808,7 +11027,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A oligopotent progenitor cell committed to the lymphoid lineage. GOC:add GOC:dsd - GOC:tfm + GOC:tfm PMID:10407577 PMID:16551251 @@ -10830,7 +11049,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A stem cell from which all cells of the body can form. GOC:add - GOC:tfm + GOC:tfm @@ -10883,7 +11102,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A cell that is commited to differentiating into a muscle cell. Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes. Myoblasts also occur as transient populations of cells in muscles undergoing repair. - GOC:tfm + GOC:tfm MESH:A11.635 PMID:21849021 @@ -10949,7 +11168,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u Skeletogenic cell that is typically non-terminally differentiated, secretes an avascular, GAG rich matrix; is not buried in cartilage tissue matrix, retains the ability to divide, located adjacent to cartilage tissue (including within the perichondrium), and develops from prechondroblast (and thus prechondrogenic) cell. - GOC:tfm + GOC:tfm GO_REF:0000034 ISBN:0618947256 @@ -11007,7 +11226,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u Skeletogenic cell that produces enamel, overlies the odontogenic papilla, and arises from the differentiation of a preameloblast cell. - GOC:tfm + GOC:tfm GO_REF:0000034 MESH:A11.436.107 @@ -11152,7 +11371,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u OBSOLETE: A classification of cells by their microscopic appearance. FB:ma - GOC:tfm + GOC:tfm @@ -11188,7 +11407,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A cell that has a filiform extrusion of the cell surface. - GOC:tfm + GOC:tfm @@ -11209,7 +11428,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A neurectoderm derived cell that lines the neural lumen. - GOC:tfm + GOC:tfm JB:jb PMID:9550134 @@ -11254,7 +11473,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina. FB:ma - GOC:tfm + GOC:tfm MESH:A11.436 @@ -11285,7 +11504,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u An epithelial cell that has a cilia. - GOC:tfm + GOC:tfm @@ -11388,7 +11607,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u An endothelial cell that lines the vasculature. - GOC:tfm + GOC:tfm @@ -11480,7 +11699,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A flattened epithelial cell of mesenchymal origin that lines the serous cavity. - GOC:tfm + GOC:tfm ISBN:0721662544 @@ -11585,7 +11804,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A cell found predominately in the blood. GOC:add - GOC:tfm + GOC:tfm @@ -11671,7 +11890,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u An epithelial cell of the pancreas. - GOC:tfm + GOC:tfm @@ -11730,7 +11949,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex. GOC:add - GOC:tfm + GOC:tfm ISBN:0781735149 @@ -11922,7 +12141,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A tissue-resident macrophage of the reticuloendothelial system found on the luminal surface of the hepatic sinusoids involved in erythrocyte clearance. Markers include F4/80+, CD11b-low, CD68-positive, sialoadhesin-positive, CD163/SRCR-positive. Irregular, with long processes including lamellipodia extending into the sinusoid lumen, have flattened nucleus with cytoplasm containing characteristic invaginations of the plasma membrane (vermiform bodies); lie within the sinusoid lumen attached to the endothelial surface; derived from the bone marrow, form a major part of the body's mononuclear phagocyte system. GOC:add - GOC:tfm + GOC:tfm GO_REF:0000031 ISBN:0517223651 MESH:A11.329.372.588 @@ -12060,7 +12279,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive. GOC:add - GOC:tfm + GOC:tfm GO_REF:0000031 ISBN:0781735149 PMID:10428500 @@ -12200,7 +12419,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A leukocyte with abundant granules in the cytoplasm. GOC:amm - GOC:tfm + GOC:tfm MESH:A11.118.637.415 MESH:D006098 http://en.wikipedia.org/wiki/Granulocyte @@ -12241,7 +12460,17 @@ Covers cells actively being cultured or stored in a quiescent state for future u - + + + + + + + + + + + @@ -12319,7 +12548,17 @@ Covers cells actively being cultured or stored in a quiescent state for future u - + + + + + + + + + + + @@ -12423,7 +12662,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A fully differentiated neutrophil, a granular leukocyte having a nucleus with three to five lobes connected by slender threads, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes. They are produced in bone marrow at a rate of 5e10-10e10/day and have a half-life of 6-8 hours. Neutrophils are CD15-positive, CD16-positive, CD32-positive, CD43-positive, CD181-positive, and CD182-positive. GOC:add - GOC:tfm + GOC:tfm MESH:A11.118.637.415.583 MESH:D009504 PMID:11138776 @@ -12597,7 +12836,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development. GOC:add GOC:dsd - GOC:tfm + GOC:tfm ISBN:068340007X MESH:A11.329.427 MESH:D008407 @@ -12658,7 +12897,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A specialized epithelial cell involved in sensory perception. Restricted to special sense organs of the olfactory, gustatory, and vestibulocochlear receptor systems; contain sensory cells surrounded by supportive, non-receptive cells. - GOC:tfm + GOC:tfm ISBN:0517223651 ISBN:0721662544 @@ -12681,7 +12920,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions. - GOC:tfm + GOC:tfm MESH:A08.663.358 @@ -12787,7 +13026,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A type of interneuron that has two neurites, usually an axon and a dendrite, extending from opposite poles of an ovoid cell body. - GOC:tfm + GOC:tfm ISBN:0444009442 @@ -12824,7 +13063,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u Neuron with an axon and two or more dendrites. FMA:67287 - GOC:tfm + GOC:tfm @@ -12843,7 +13082,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u Neuron with two neurites that are fused grossly when they protrude from the soma and bifurcate a short distance from the soma. FMA:67305 - GOC:tfm + GOC:tfm @@ -12897,7 +13136,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A neruon whose cell body is within an autonomic ganglion. - GOC:tfm + GOC:tfm @@ -12935,7 +13174,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A neuron that uses acetylcholine as a vesicular neurotransmitter. - GOC:tfm + GOC:tfm @@ -13027,7 +13266,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A vertebrate phagocyte with a single nucleus. GOC:add - GOC:tfm + GOC:tfm ISBN:0781735149 @@ -13064,7 +13303,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm. - GOC:tfm + GOC:tfm MESH:D042783 PMID:21275341 http://en.wikipedia.org/wiki/Endothelial_cell @@ -13087,7 +13326,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u Pioneer neurons establish a pathway in the developing central nervous system and then undergo programmed cell death once the adult axons, which follow them, have made connections with the target site. Thus, they are a transient cell type involved in axon guidance. GOC:cvs - GOC:tfm + GOC:tfm @@ -13356,7 +13595,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A neuroglial cell of ectodermal origin, i.e., the astrocytes and oligodendrocytes considered together. - GOC:tfm + GOC:tfm ISBN:0721662544 @@ -13380,7 +13619,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from 'star' cells) are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier. They regulate the extracellular ionic and chemical environment, and 'reactive astrocytes' (along with microglia) respond to injury. GOC:dsd - GOC:tfm + GOC:tfm MESH:A08.637.200 MESH:D001253 PMID:11746784 @@ -13524,7 +13763,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive. GOC:add GOC:dsd - GOC:tfm + GOC:tfm ISBN:0721601464 MESH:D017628 PMID:11517395 @@ -13608,7 +13847,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u Cell of the single layer of large flattened cells covering the surface of the cornea. - GOC:tfm + GOC:tfm MESH:A09.371.060.067.31 @@ -13627,7 +13866,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u Ectoderm destined to be nervous tissue. - GOC:tfm + GOC:tfm ISBN:068340007X @@ -13769,7 +14008,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u An inactive fibroblast; cytoplasm is sparse, endoplasmic reticulum is scanty with flattened nucleus. Term used by some histologists; when fibroblasts become relatively inactive in fiber formation. However, this cell has the potential for fibrogenesis in quiescent connective tissue of the adult, as well as during development, other histologists prefer to use the term fibroblast in all circumstances. These cells represent ~0.5% of peripheral blood leukocytes. GOC:dsd - GOC:tfm + GOC:tfm ISBN:0412046911 ISBN:0517223651 PMID:11641248 @@ -13843,7 +14082,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A mature osteoblast that has become embedded in the bone matrix. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi. - GOC:tfm + GOC:tfm MESH:A11.329.629.500 @@ -13965,7 +14204,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A cell occurring in the peripheral part of the vitreous body of the eye that may be responsible for production of hyaluronic acid and collagen. - GOC:tfm + GOC:tfm PMID:19073178 @@ -14064,7 +14303,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A pigment cell is a cell that contains pigment granules. - GOC:tfm + GOC:tfm @@ -14159,7 +14398,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A specialized epithelial cell that is capable of synthesizing and secreting certain biomolecules. - GOC:tfm + GOC:tfm @@ -14195,7 +14434,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A cell that specializes in controlled release of one or more substances. - GOC:tfm + GOC:tfm ISBN:0721662544 @@ -14251,7 +14490,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A cell that secretes glycosaminoglycans. - GOC:tfm + GOC:tfm @@ -14301,7 +14540,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A cell that is usually basal in position, cuboidal with round nucleus, short microvilli, secretes pepsinogen. - GOC:tfm + GOC:tfm @@ -14353,7 +14592,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A cell that specializes in secretion of surfactant in the alveoli of the lung. - GOC:tfm + GOC:tfm ISBN:0721662544 @@ -14420,7 +14659,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u Epithelial progenitor cell of the lung. Club cells are dome-shaped with short microvilli but no cilia. They function to protect the bronchiolar epithelium. Club cells also multiply and differentiate into ciliated cells to regenerate the bronchiolar epithelium. DOI:10.1183/09031936.00146609 DOI:https://doi.org/10.1378/chest.12-2762 - GOC:tfm + GOC:tfm PMID:28128362 PMID:7905712 @@ -14508,7 +14747,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A large, oval stomach epithelial cell with a central nucleus; source of gastric acid. Secretes HCl. - GOC:tfm + GOC:tfm ISBN:0517223651 @@ -14571,7 +14810,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas. - GOC:tfm + GOC:tfm SANBI:mhl @@ -14751,7 +14990,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A cell that secretes insulin and is located towards the center of the islets of Langerhans. - GOC:tfm + GOC:tfm ISBN:0517223651 http://en.wikipedia.org/wiki/Pancreatic_b_cell @@ -14843,7 +15082,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A cell that secretes glucagon. - GOC:tfm + GOC:tfm @@ -14889,7 +15128,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A type of enteocrine cell found in the periphery of the islets of Langerhans that secretes glucagon. - GOC:tfm + GOC:tfm ISBN:0721662544 @@ -14968,7 +15207,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A D cell located in the pancreas. Peripherally placed within the islets like type A cells; contains somatostatin. FMA:0517223651 - GOC:tfm + GOC:tfm @@ -15106,7 +15345,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis. - GOC:tfm + GOC:tfm PMID:12050120 @@ -15234,7 +15473,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated. - GOC:tfm + GOC:tfm ISBN:0412046911 MESH:A11.436.348 PMID:19717280 @@ -15279,7 +15518,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u Contractile cells resembling smooth muscle cells that are present in glands, notably the mammary gland, and aid in secretion. This cell has long weaving dendritic processes containing myofilament. - GOC:tfm + GOC:tfm ISBN:0721662544 @@ -15302,7 +15541,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u An animal cell that has characteristics of both a fibroblast cell and a smooth muscle cell. GOC:dsd - GOC:tfm + GOC:tfm MESH:D058628 PMID:19800625 PMID:20630469 @@ -15383,7 +15622,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A somatic cell located in skeletal muscle. - GOC:tfm + GOC:tfm @@ -15408,7 +15647,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A muscle cell that develops tension more slowly than a fast-twitch fiber. - GOC:tfm + GOC:tfm ISBN:0323052908 @@ -15439,7 +15678,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A muscle cell that can develop high tension rapidly. It is usually innervated by a single alpha neuron . - GOC:tfm + GOC:tfm ISBN:0323052908 @@ -15796,7 +16035,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A cellular receptor which mediates the sense of temperature. Thermoreceptor cells in vertebrates are mostly located under the skin. In mammals there are separate types of thermoreceptors for cold and for warmth and pain receptor cells which detect cold or heat extreme enough to cause pain. - GOC:tfm + GOC:tfm MESH:A08.800.550.700.840 MP:0000971 @@ -15929,7 +16168,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A cell type found in the spherical or ovoid clusters of receptor cells found mainly in the epithelium of the tongue and constituting the end organs of the sense of taste. - GOC:tfm + GOC:tfm ISBN:0618947256 @@ -16073,7 +16312,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A meso-epithelial cell that lies between the cartilaginous fibers in the synovial membrane of a joint and produces hyaluronic acid. - GOC:tfm + GOC:tfm ISBN:0721662544 PMID:17942474 @@ -16173,7 +16412,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A neuroglial cell of the peripheral nervous system which forms the insulating myelin sheaths of peripheral axons. GOC:cvs - GOC:tfm + GOC:tfm MESH:A08.637.800 @@ -16320,7 +16559,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u OBSOLETE: A classification of cells by the number of their nuclei. FB:ma - GOC:tfm + GOC:tfm @@ -16392,7 +16631,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A cell with a single nucleus. FB:ma - GOC:tfm + GOC:tfm @@ -16575,7 +16814,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen. - GOC:tfm + GOC:tfm MESH:A11.118.290 @@ -16652,7 +16891,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation. GOC:add GOC:dsd - GOC:tfm + GOC:tfm MESH:A11.118.188 MESH:D001792 PMID:11110672 @@ -16762,7 +17001,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells. GOC:add - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:16213494 PMID:1919437 @@ -16815,7 +17054,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A lymphocyte of B lineage that is capable of B cell mediated immunity. GOC:add - GOC:tfm + GOC:tfm GO_REF:0000031 ISBN:0781735149 @@ -16824,7 +17063,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A lymphocyte of B lineage with the phenotype CD19-positive, CD20-positive, and capable of B cell mediated immunity. GOC:add - GOC:tfm + GOC:tfm GO_REF:0000031 ISBN:0781735149 @@ -16957,7 +17196,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A cell characteristically found lining hollow organs that are subject to great mechanical change due to contraction and distention; originally thought to represent a transition between stratified squamous and columnar epithelium. - GOC:tfm + GOC:tfm ISBN:0721662544 @@ -17768,7 +18007,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A peptide hormone secreting cell that produces growth hormone, somatotropin. - GOC:tfm + GOC:tfm SANBI:mhl @@ -17892,7 +18131,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A mature sexual reproductive cell having a single set of unpaired chromosomes. - GOC:tfm + GOC:tfm ISBN:0721662544 @@ -18014,7 +18253,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u An epithelial cell found in the trachea. - GOC:tfm + GOC:tfm @@ -18153,7 +18392,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u Columnar glandular cell with irregular nucleus, copious granular endoplasmic reticulum and supranuclear granules. Secretes a watery fluid containing proteins known as serous fluid. - GOC:tfm + GOC:tfm ISBN:0517223651 ISBN:0721662544 @@ -18334,7 +18573,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u An epithelial cell that lines the peripheral gas exchange region of the lungs of air-breathing vertebrates. - GOC:tfm + GOC:tfm PMID:20054144 @@ -18565,7 +18804,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors. - GOC:tfm + GOC:tfm PMID:5025404 @@ -18610,7 +18849,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A cell found within the adrenal medulla that secrete biogenic amine hormones upon stimulation. - GOC:tfm + GOC:tfm http://www.britannica.com/EBchecked/topic/6405/adrenal-gland @@ -18659,7 +18898,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u An early neural cell developing from the early ependymal cell of the neural tube. - GOC:tfm + GOC:tfm ISBN:0618947256 @@ -18725,7 +18964,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u Any animal cell containing pigment granules. - GOC:tfm + GOC:tfm ISBN:0721662544 @@ -18768,7 +19007,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A pigment cell that is capable of detecting light stimulus that is involved in visual perception. - GOC:tfm + GOC:tfm @@ -18808,7 +19047,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A mesenchymal cell that is part of a small mass of condensed mesenchyme in the enamel organ; it differentiates into the dentin and dental pulp. - GOC:tfm + GOC:tfm ISBN:0721662544 @@ -18857,7 +19096,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A specialized mesenchymal cell that resides in the dermal papilla located at the bottom of hair follicles. This cell plays a pivotal roles in hair formation, growth, and cycling. - GOC:tfm + GOC:tfm PMID:9893172 @@ -19025,7 +19264,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A cell lining the outside of the blastocyst. After binding to the endometrium, trophoblast cells develop into two distinct layers, an inner layer of mononuclear cytotrophoblast cells and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblast cells, which form the early fetal-maternal interface. - GOC:tfm + GOC:tfm MESH:A11.936 @@ -19043,7 +19282,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A cell of the outer layer of a blastula that gives rise to the ectoderm after gastrulation. - GOC:tfm + GOC:tfm ISBN:0618947256 @@ -19216,7 +19455,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A smooth muscle cell assocatiated with the vasculature. GOC:dsd - GOC:tfm + GOC:tfm @@ -19778,7 +20017,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u An elongated fibrocyte that is part of a tendon. The cytoplasm is stretched between the collagen fibres of the tendon. They have a central cell nucleus with a prominent nucleolus. Tendon cells have a well-developed rough endoplasmic reticulum and they are responsible for synthesis and turnover of tendon fibres and ground substance. GOC:NV - GOC:tfm + GOC:tfm PMID:957445 @@ -19956,7 +20195,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u Obsolete. Consult Plant Ontology instead. OBSOLETED, not defined prior to obsoletion. - GOC:tfm + GOC:tfm @@ -20138,19 +20377,21 @@ Covers cells actively being cultured or stored in a quiescent state for future u - + - An epithelial cell of the hypodermis of flatworms. + An epithelial cell of the hypodermis of Caenorhabditis. + roundworm hypodermal cell WBbt:0007846 cell - flatworm hypodermal cell + This term was originally added to CL for parity with the Worm anatomy ontology, which is dedicated to C elegans. It is not clear if it makes sense to try and generalize the concept and include in CL, and this term may be obsoleted in future. Note there is no similarity to the hypodermis in vertebrates. + Caenorhabditis hypodermal cell - An epithelial cell of the hypodermis of flatworms. - GOC:tfm + An epithelial cell of the hypodermis of Caenorhabditis. + GOC:tfm http://www.wormatlas.org/hermaphrodite/hypodermis/mainframe.htm @@ -20203,7 +20444,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A cell whose nucleus contains a single haploid genome. FB:ma - GOC:tfm + GOC:tfm @@ -20226,7 +20467,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u OBSOLETE: A classification of cells by the number of haploid genome equivalents of their nucleus or nuclei. FB:ma - GOC:tfm + GOC:tfm @@ -20283,7 +20524,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u An epithelial cell found in C. elegans that firmly hold the outer body wall and the lips to the inner cylinder of the pharynx in a manner that keeps these organs from breaking apart, while still giving each organ freedom of movement during feeding. - GOC:tfm + GOC:tfm http://www.wormatlas.org/ver1/handbook/hypodermis/hypsupportother.htm#arcadecells @@ -20302,7 +20543,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u An epithelial fate stem cell found in flatworms. - GOC:tfm + GOC:tfm http://www.wormatlas.org/hermaphrodite/seam%20cells/mainframe.htm @@ -20334,7 +20575,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A free floating cell, including amebocytes and eleocytes, in the coelom of certain animals, especially annelids. - GOC:tfm + GOC:tfm ISBN:0721662544 @@ -20380,7 +20621,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A cell involved in the elimination of metabolic and foreign toxins, and in maintaining the ionic, acid-base and water balance of biological fluids. - GOC:tfm + GOC:tfm PMID:19783135 @@ -20427,7 +20668,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A scaffolding cell type found in C. elegans, this cell plays a supportive role to the muscle arms. May also have an endocrine role. - GOC:tfm + GOC:tfm http://wormatlas.psc.edu/hermaphrodite/muscleGLR/mainframe.htm @@ -20516,7 +20757,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u Large, stellate fibroblast found along the network of collagen fibers of the reticulum of the spleen; synthesize the matrix components of the reticulum. - GOC:tfm + GOC:tfm ISBN:0517223651 http://en.wikipedia.org/wiki/Reticular_cell @@ -20606,7 +20847,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A rounded cell that is usually situated next to sinusoids; secretes follicular stimulating hormone (FSH) and luteinizing hormone (LH). - GOC:tfm + GOC:tfm ISBN:0517223651 http://en.wikipedia.org/wiki/Gonadotroph @@ -20642,7 +20883,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A peptide hormone secreting cell pituitary that produces luteinizing hormone. - GOC:tfm + GOC:tfm @@ -20677,7 +20918,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A peptide hormone cell that secretes prolactin. - GOC:tfm + GOC:tfm SANBI:mhl @@ -20849,7 +21090,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u An epithelial cell of the parathyroid gland that is arranged in wide, irregular interconnecting columns; responsible for the synthesis and secretion of parathyroid hormone. FMA:69078 - GOC:tfm + GOC:tfm ISBN:0517223651 @@ -20894,7 +21135,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u Fat cells with light coloration and few mitochondria. They contain a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole. - GOC:tfm + GOC:tfm MESH:A11.329.114.500 @@ -21167,7 +21408,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A cell capable of producing epinephrine. Epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme, which is expressed in the adrenal glands, androgenic neurons, and in other cell types. - GOC:tfm + GOC:tfm PMID:12438093 @@ -21265,7 +21506,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A cell type that secretes 5-Hydroxytryptamine (serotonin). - GOC:tfm + GOC:tfm PMID:19630576 @@ -21303,7 +21544,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A cell capable of producting norepiniphrine. Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. In addition, epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme. - GOC:tfm + GOC:tfm ISBN:068340007X @@ -21393,7 +21634,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u An epidermal progenitor cell that arises from neuroectoderm and in turn gives rise to the epidermal sheath of ventral and cephalic regions. - GOC:tfm + GOC:tfm PMID:7576311 @@ -21446,7 +21687,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A peptide hormone secreting cell that produces adrenocorticotropin, or corticotropin. - GOC:tfm + GOC:tfm SANBI:mhl @@ -21567,7 +21808,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u An insect renal cell that filters hemolymph and is found with other pericardial nephrocytes in two rows flanking the dorsal vessel. FBbt:00003184 GO:0061320 - GOC:tfm + GOC:tfm PMID:19783135 @@ -21802,7 +22043,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u Mast cell subtype whose granules contain both the serine proteases tryptase and chymase. These cells are primarily found in connective tissue, such as the peritoneal cavity, skin, and intestinal submucosa. Their development is T-cell independent. GOC:add GOC:dsd - GOC:tfm + GOC:tfm PMID:19923473 PMID:9354811 @@ -21883,7 +22124,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A large binucleate cell that forms a 'garland' around the anterior end of the proventriculus (cardia) at its junction with the esophagus in both adults and larvae flies. Each cell is surrounded by a basement membrane and there are numerous micro-invaginations (lacunae) extending from the surface into the cytoplasm. At the mouth of each lacuna is a doubled filament forming a specialised filtration system (diaphragm). The filtrate is endocytosed from the lacunae. - GOC:tfm + GOC:tfm PMID:19783135 fbbt:00005059 @@ -21944,7 +22185,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A photoreceptor cell that detects visible light. - GOC:tfm + GOC:tfm @@ -22036,7 +22277,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A CD4-positive, alpha-beta T cell that cooperates with other lymphocytes via direct contact or cytokine release to initiate a variety of immune functions. GOC:add GOC:pam - GOC:tfm + GOC:tfm GO_REF:0000031 ISBN:0781735149 MESH:A11.118.637.555.567.569.200.400 @@ -22085,7 +22326,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A photoreceptor cell that detects ultraviolet light. - GOC:tfm + GOC:tfm @@ -22154,7 +22395,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u An interneuron (also called relay neuron, association neuron or local circuit neuron) is a multipolar neuron which connects afferent neurons and efferent neurons in neural pathways. Like motor neurons, interneuron cell bodies are always located in the central nervous system (CNS). - GOC:tfm + GOC:tfm http://en.wikipedia.org/wiki/Interneuron @@ -22180,7 +22421,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A connective tissue cell of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere. - GOC:tfm + GOC:tfm MESH:A11.329.830 @@ -22281,7 +22522,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A enteroendocrine cell part of the glands of the gastric mucosa. They produce histamine and peptides such as chromogranins. This cell type respond to gastrin by releasing histamine which acts as a paracrine stimulator of the release of hydrochloric acid from the gastric parietal cells. - GOC:tfm + GOC:tfm MESH:A06.224.365 @@ -22362,7 +22603,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u An endocrine cell found in the pyloric gland mucosa (antral mucosa) of the stomach of mammals and responsible for the secretion of gastrin and enkephalin. Most abundant in pyloric antrum, pyramidal in form with a narrow apex bearing long microvilli. - GOC:tfm + GOC:tfm ISBN:0517223651 MESH:A03.492.766.440.300 @@ -22408,7 +22649,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u An epithelial cell found in the basal part of the intestinal glands (crypts of Lieberkuhn) including the appendix. Paneth cells synthesize and secrete lysozyme and cryptdins. Numerous in the deeper parts of the intestinal crypts, particularly in the duodenum, rich in zinc, contain large acidophilic granules, with irregular apical microvilli and prominent membrane-bound vacuoles containing matrix. - GOC:tfm + GOC:tfm ISBN:0517223651 MESH:A03.492.411.369.700 @@ -22444,7 +22685,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A paracrine cell is a secretory cell that secretes an agonist into intercellular spaces in which it diffuses to a target cell other than that which produced it. - GOC:tfm + GOC:tfm ISBN:0198529171 @@ -22488,7 +22729,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A precursor cell destined to differentiate into cardiac muscle cell. - GOC:tfm + GOC:tfm MESH:A11.635.470 @@ -22532,7 +22773,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A precursor cell destined to differentiate into smooth muscle myocytes. - GOC:tfm + GOC:tfm MESH:A11.635.510 MESH:D032390 @@ -22616,7 +22857,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A non-neuronal cell that surrounds the neuronal cell bodies of the ganglia. - GOC:tfm + GOC:tfm MESH:A08.340.685 @@ -22665,7 +22906,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A phagocyte in vertebrates that is able to phagocytosis. - GOC:tfm + GOC:tfm @@ -22692,7 +22933,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A phagocyte from organisms in the Nematoda or Protostomia clades. - GOC:tfm + GOC:tfm @@ -22776,7 +23017,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A cell from the inner layer of the trophoblast of the early mammalian embryo that gives rise to the outer surface and villi of the chorion. Mononuclear crytoblasts fuse to give rise to a multinuclear cytotrophoblast. - GOC:tfm + GOC:tfm ISBN:0323052908 @@ -22828,7 +23069,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo, directly associated with the maternal blood supply. It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy. - GOC:tfm + GOC:tfm ISBN:0323052908 @@ -22848,7 +23089,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A neuron which conveys sensory information centrally from the periphery. - GOC:tfm + GOC:tfm MESH:A08.663.650 @@ -23105,7 +23346,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A cell that originates from the neural crest and differentiates into a pigment cell. - GOC:tfm + GOC:tfm SANBI:mhl @@ -23291,7 +23532,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive, CXCR3-positive, CCR6-negative, and is capable of producing interferon-gamma. GOC:add GOC:pam - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:19375293 PMID:20303875 @@ -23379,7 +23620,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A CD4-positive, alpha-beta T cell that has the phenotype GATA-3-positive, CXCR3-negative, CCR6-negative, and is capable of producing interleukin-4. GOC:add GOC:pam - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:19375293 PMID:20103781 @@ -23684,7 +23925,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared. This cell is CD71-positive and lacks hematopoeitic lineage markers. - GOC:tfm + GOC:tfm ISBN:0721601464 @@ -24106,7 +24347,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative). GOC:dsd - GOC:tfm + GOC:tfm ISBN:0721601464 @@ -24149,7 +24390,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A peptide hormone secreting cell that secretes gastrin stimulating hormone. - GOC:tfm + GOC:tfm @@ -24331,7 +24572,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1. GOC:amm GOC:dsd - GOC:tfm + GOC:tfm GO_REF:0000031 ISBN:0721601464 MESH:D055014 @@ -24547,7 +24788,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds. GOC:add - GOC:tfm + GOC:tfm PMID:15946868 PMID:2037622 @@ -24613,7 +24854,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A precursor in the monocytic series, being a cell intermediate in development between the monoblast and monocyte. This cell is CD11b-positive and has fine azurophil granules. - GOC:tfm + GOC:tfm ISBN:0721601464 @@ -24762,7 +25003,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A late neutrophilic metamyelocyte in which the nucleus is indented to more than half the distance to the farthest nuclear margin but in no area being condensed to a single filament. The nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature neutrophil. These cells are fMLP receptor-positive, CD11b-positive, CD35-negative, and CD49d-negative. GOC:add GOC:dsd - GOC:tfm + GOC:tfm ISBN:0721601464 PMID:10618520 PMID:12560239 @@ -24795,7 +25036,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u Interneuron of the vertebrate retina. They integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. They lack large axons. - GOC:tfm + GOC:tfm MESH:A08.663.358.050 @@ -24859,7 +25100,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A rounded, inactive form that certain bacteria assume under conditions of extreme temperature, dryness, or lack of food. The bacterium develops a waterproof cell wall that protects it from being dried out or damaged. - GOC:tfm + GOC:tfm ISBN:0618947256 @@ -24967,7 +25208,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A promyelocyte committed to the neutrophil lineage. This cell type is GATA-1-positive, C/EBPa-positive, AML-1-positive, MPO-positive, has low expression of PU.1 transcription factor and lacks lactotransferrin expression. GOC:add GOC:dsd - GOC:tfm + GOC:tfm ISBN:0721601464 PMID:12560239 PMID:15514007 @@ -25058,7 +25299,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A mesenchymal stem cell capable of developing into blood vessel endothelium. GOC:dsd - GOC:tfm + GOC:tfm PMID:12768659 @@ -25089,7 +25330,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A cell that originates in the neural crest, that has certain cytochemical and ultrastructural characteristics and is found scattered throughout the body; types include melanocytes, the cells of the chromaffin system, and cells in the hypothalamus, hypophysis, thyroid, parathyroids, lungs, gastrointestinal tract, and pancreas. This cell type concentrates the amino acid precursors of certain amines and decarboxylate them, forming amines that function as regulators and neurotransmitters. This cell type produces substances such as epinephrine, norepinephrine, dopamine, serotonin, enkephalin, somatostatin, neurotensin, and substance P, the actions of which may affect contiguous cells, nearby groups of cells, or distant cells, thus functioning as local or systemic hormones. The name is an acronym for amine precursor uptake and decarboxylation cell. - GOC:tfm + GOC:tfm ISBN:0721662544 MESH:A11.070 @@ -25210,7 +25451,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A neuroepithelial cells that occurs singly or in small groups, close to the outer follicular borders but within the follicular basement membrane of the thyroid. Expresses a form of the neural cell adhesion molecule (N-CAM) on their surface. Secretes calcitonin, 5-hydroxytryptamine and dopamine. - GOC:tfm + GOC:tfm ISBN:0517223651 @@ -25353,7 +25594,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u An epithelial cell of the cornea. - GOC:tfm + GOC:tfm @@ -25681,7 +25922,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A neutrophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte; in this stage, production of primary granules is complete and neutrophil-specific granules has started. No nucleolus is present. This cell type is CD13-positive, CD16-negative, integrin alpha-M-positive, CD15-positive, CD33-positive, CD24-positive, C/EBP-a-positive, C/EBPe-positive, PU.1-positive, lactotransferrin-positive, myeloperoxidase-positive and NGAL-positive. GOC:add GOC:dsd - GOC:tfm + GOC:tfm ISBN:0721601464 PMID:10618520 PMID:12560239 @@ -26027,7 +26268,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A neutrophil precursor in the granulocytic series, being a cell intermediate in development between a myelocyte and the band form neutrophil. The protein synthesis seen in earlier stages decreases or stops; the nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare; and the cytoplasm becomes amphophilic like that of a mature granulocyte. This cell type is integrin alpha-M-positive, CD13-negative, CD15-positive, CD16-positive, CD33-positive, CD24-positive, fMLP receptor-negative and has expression of C/EBP-a, C/EBP-e, PU.1 transcription factor, lactotransferrin, myeloperoxidase and neutrophil gelatinase associated lipocalin. GOC:add GOC:dsd - GOC:tfm + GOC:tfm ISBN:0721601464 PMID:10618520 PMID:12560239 @@ -26165,7 +26406,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A tissue-resident macrophage found in the alveoli of the lungs. Ingests small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells. Markers include F4/80-positive, CD11b-/low, CD11c-positive, CD68-positive, sialoadhesin-positive, dectin-1-positive, MR-positive, CX3CR1-negative. GOC:ana GOC:dsd - GOC:tfm + GOC:tfm GO_REF:0000031 MESH:A11.329.372.600 @@ -26249,7 +26490,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A thermoreceptor cell that detects reduced temperatures. - GOC:tfm + GOC:tfm @@ -26339,7 +26580,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A progesterone secreting cell in the corpus luteum that develops from theca cells. - GOC:tfm + GOC:tfm MESH:A05.360.319.114.630.278.400 @@ -26357,7 +26598,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A thermoreceptor cell that detects increased temperatures. - GOC:tfm + GOC:tfm https://orcid.org/0000-0001-5208-3432 @@ -26385,7 +26626,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A large, progesterone secreting cell in the corpus luteum that develops from the granulosa cells. - GOC:tfm + GOC:tfm MESH:A05.360.319.114.630.278.400 @@ -26420,7 +26661,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A steroid hormone secreting cell that secretes androgen. - GOC:tfm + GOC:tfm @@ -26439,7 +26680,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u An elongated, spindle-shaped, cell that is located between the basal lamina and the plasmalemma of a muscle fiber. These cells are mostly quiescent, but upon activation they divide to produce cells that generate new muscle fibers. - GOC:tfm + GOC:tfm MESH:A11.635.500.700 PMID:21849021 PMID:23303905 @@ -26486,7 +26727,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u An erythrocyte lacking a nucleus. GOC:add - GOC:tfm + GOC:tfm @@ -26506,7 +26747,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A spore formed following meiosis. Sometimes following meiosis, prospores may undergo one or more rounds of mitosis before they are fully mature. FAO:0000017 - GOC:tfm + GOC:tfm SGD:clt @@ -26525,7 +26766,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u The smaller of two types of asexual spores formed by some fungi. An ovoid to pear-shaped asexual spore that contains very little cytoplasm and organelles, is uninucleate, and forms in vegetative hypae within a mycelium. Micronidia are extruded from the hyphal cell wall. - GOC:tfm + GOC:tfm ISBN:0471940526 PMID:8357339 SGD:clt @@ -26570,7 +26811,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u Pyramidal neurons have a pyramid-shaped soma with a single axon, a large apical dendrite and multiple basal dendrites. The apex and an apical dendrite typically point toward the pial surface and other dendrites and an axon emerging from the base. The axons may have local collaterals but also project outside their region. Pyramidal neurons are found in the cerebral cortex, the hippocampus, and the amygdala. - GOC:tfm + GOC:tfm MESH:A08.186.211.577.405.700 @@ -26710,7 +26951,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A spore formed following mitosis or mitoses. - GOC:tfm + GOC:tfm PMID:2524423 PMID:9529886 SGD:clt @@ -26731,7 +26972,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u The larger of two types of asexual spores formed by some fungi; usually round or oblong. - GOC:tfm + GOC:tfm ISBN:0471940526 SGD:clt @@ -26752,7 +26993,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A thick walled spore that stores and protects one or more nuclei following sexual reproduction in an Ascomycete. - GOC:tfm + GOC:tfm ISBN:08199377X SGD:clt @@ -26793,7 +27034,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A mechanoreceptor located in the acoustic maculae and the semicircular canals that mediates the sense of balance, movement, and head position. The vestibular hair cells are connected to accessory structures in such a way that movements of the head displace their stereocilia. This influences the membrane potential of the cells which relay information about movements via the vestibular part of the vestibulocochlear nerve to the brain stem. - GOC:tfm + GOC:tfm MESH:A08.663.650.250.380 @@ -27523,7 +27764,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A basophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte; in this stage, production of primary granules is complete and basophil-specific granules has started. No nucleolus is present. Markers are being integrin alpha-M-positive, fucosyltransferase FUT4-positive, CD33-positive, CD24-positive, aminopeptidase N-positive. GOC:add - GOC:tfm + GOC:tfm ISBN:0721601464 PMID:18466030 http://www.cap.org @@ -27602,7 +27843,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A neuron that uses GABA as a vesicular neurotransmitter - GOC:tfm + GOC:tfm @@ -27684,7 +27925,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus). - GOC:tfm + GOC:tfm http://www.copewithcytokines.de @@ -27883,7 +28124,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A T cell expressing an alpha-beta T cell receptor and the CD8 coreceptor. GOC:add - GOC:tfm + GOC:tfm ISBN:0781735149 @@ -27995,7 +28236,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A cell whose primary function is to support other cell types. FB:ma - GOC:tfm + GOC:tfm @@ -28101,7 +28342,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A tall supporting cell that is arranged in rows adjacent to the last row of outer phalangeal cells. This cell type constitutes the outer border of the organ of Corti. - GOC:tfm + GOC:tfm ISBN:0721662544 @@ -28123,7 +28364,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A cuboidal cell which along with Boettcher's cells form the floor of the external spiral sulcus, external to the organ of Corti. - GOC:tfm + GOC:tfm ISBN:0721662544 @@ -28144,7 +28385,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u The outer phalangeal cells of the organ of Corti. This cell holds the base of the hair cell in a cup-shaped depression. - GOC:tfm + GOC:tfm ISBN:0721662544 http://www.britannica.com/EBchecked/topic/156177/Deiters-cell @@ -28196,7 +28437,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A cell that stains readily in the anterior pituitary gland. - GOC:tfm + GOC:tfm ISBN:0618947256 @@ -28225,7 +28466,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u An acidophilic chromophil cell that of the anterior pituitary gland. - GOC:tfm + GOC:tfm @@ -28246,7 +28487,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A basophillic chromophil cell that of the anterior pituitary gland. - GOC:tfm + GOC:tfm @@ -28265,7 +28506,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A cell that is resistant to stains. - GOC:tfm + GOC:tfm @@ -28303,7 +28544,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u Type of radial astrocyte in the cerebellar cortex that have their cell bodies in the Purkinje cell layer and processes that extend into the molecular layer, terminating with bulbous endfeet at the pial surface. Bergmann glia express high densities of glutamate transporters that limit diffusion of the neurotransmitter glutamate during its release from synaptic terminals. Besides their role in early development of the cerebellum, Bergmann glia are also required for the pruning or addition of synapses. - GOC:tfm + GOC:tfm http://www.neurolex.org/wiki/Category:Bergmann_Glial_Cell @@ -28344,7 +28585,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u Undifferentiated; mitotic stem cell for other epithelial cell types; rounded or elliptical with little cytoplasm and few organelles; contain cytokeratin intermediate filament. - GOC:tfm + GOC:tfm ISBN:0517223651 @@ -28415,7 +28656,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A phagocytic cell formed by the fusion of macrophages, occurs in chronic inflammatory responses to persistent microorganism such as M.tuberculosis, component of granulomas. Sometimes used to refer to megakaryocytes. GOC:add - GOC:tfm + GOC:tfm ISBN:0702022918 ISBN:0702024783 @@ -28498,7 +28739,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A smooth muscle cell that synthesizes, stores, and secretes the enzyme renin. This cell type are located in the wall of the afferent arteriole at the entrance to the glomerulus. While having a different origin than other kidney smooth muscle cells, this cell type expresses smooth muscle actin upon maturation. GOC:cvs - GOC:tfm + GOC:tfm PMID:11457727 @@ -28525,7 +28766,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A cell with delicate radiating processes known as desmosomes that form intercellular bridges between other cells of this type. This cell type forms the stratum spinosum (prickle cell layer). A function of this cell is to generate keratin. - GOC:tfm + GOC:tfm ISBN:0721662544 ISBN:0815332181 @@ -28555,7 +28796,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A cell type that encapsulates the capillaries and venules in the kidney. This cell secretes mesangial matrix that provides the structural support for the capillaries. - GOC:tfm + GOC:tfm http://www.copewithcytokines.de/cope.cgi?key=mesangial%20cells @@ -28575,7 +28816,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A mucus-secreting cell, with numerous apical secretory vesicles containing mucins; nucleus are basally displaced; numerous at the neck of mucus secreting glands - GOC:tfm + GOC:tfm @@ -28608,7 +28849,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u This cell type produces and secretes melatonin and forms the pineal parenchyma. Extending from each cell body, which has a spherical, oval or lobulated mucleus, are one or more tortuous basophilic processes, containing parallel microtubules known as synaptic ribbons. These processes end in expanded terminal buds near capillaries or less, frequently, ependymal cells of the pineal recess. The terminal buds contain granular endoplasmic reticulum, mitochondria and electron-dense cored vesicles, which store monoamines and polypeptide hormones, release of which appears to require sympathetic innervation. - GOC:tfm + GOC:tfm ISBN:0517223651 PMID:16687276 http://en.wikipedia.org/wiki/Pinealocyte @@ -28641,7 +28882,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A glomerular visceral epithelial cell is a specialized kidney epithelial cell that contains "feet" that interdigitate with the "feet" of other glomerular epithelial cells. - GOC:tfm + GOC:tfm @@ -28702,7 +28943,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A primary oocyte is an oocyte that has not completed female meosis I. - GOC:tfm + GOC:tfm ISBN:0721662544 @@ -28752,7 +28993,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A secondary oocyte is an oocyte that has not completed meiosis II. - GOC:tfm + GOC:tfm ISBN:0721662544 @@ -28806,7 +29047,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A diploid cell that has derived from a spermatogonium and can subsequently begin meiosis and divide into two haploid secondary spermatocytes. - GOC:tfm + GOC:tfm ISBN:0721662544 @@ -28862,7 +29103,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u One of the two haploid cells into which a primary spermatocyte divides, and which in turn gives origin to spermatids. - GOC:tfm + GOC:tfm ISBN:0721662544 @@ -28881,7 +29122,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u An epithelial cell that secretes cuticle. - GOC:tfm + GOC:tfm @@ -28899,7 +29140,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u An extracellular matrix secreting cell that secretes eggshell. - GOC:tfm + GOC:tfm @@ -28916,7 +29157,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u An extracellular matrix secreting cell that secretes glycocalyx. - GOC:tfm + GOC:tfm @@ -28997,7 +29238,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u An extracellular matrix secreting cell that secretes collagen. - GOC:tfm + GOC:tfm @@ -29048,7 +29289,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u An elongated, contractile cell found wrapped about precapillary arterioles outside the basement membrane. Pericytes are present in capillaries where proper adventitia and muscle layer are missing (thus distingushing this cell type from adventitial cells). They are relatively undifferentiated and may become fibroblasts, macrophages, or smooth muscle cells. GOC:dsd - GOC:tfm + GOC:tfm ISBN:0721662544 MESH:D020286 PMID:16807374 @@ -29113,7 +29354,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A primordial germ cell is a diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells. - GOC:tfm + GOC:tfm PMID:1381289 @@ -29189,7 +29430,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A mature sexual reproductive cell of the female germline. - GOC:tfm + GOC:tfm @@ -29355,7 +29596,7 @@ radial glial cells acting as neural progenitors throughout life. An absorptive cell of the gut epithelium that endocytoses microorganisms and intact macromolecules from the gut lumen and transports them to the subepithelial space where they are presented to antigen-presenting cells and lymphocytes. GOC:jb - GOC:tfm + GOC:tfm @@ -29455,7 +29696,7 @@ radial glial cells acting as neural progenitors throughout life. A columnar/cuboidal epithelial cell that secretes cerebrospinal fluid. - GOC:tfm + GOC:tfm @@ -29619,7 +29860,7 @@ radial glial cells acting as neural progenitors throughout life. NGF cell - PMID:18568015 + PMID:18568015 @@ -29682,7 +29923,7 @@ radial glial cells acting as neural progenitors throughout life. A cell that stores and secretes pancreatic polypeptide hormone. - GOC:tfm + GOC:tfm JB:jb PMID:15153415 @@ -29729,7 +29970,7 @@ radial glial cells acting as neural progenitors throughout life. A type of glomus or chief cell, is sensitive to hypoxia and produce catecholamines. - GOC:tfm + GOC:tfm @@ -29896,7 +30137,7 @@ radial glial cells acting as neural progenitors throughout life. Specialized ependymal cell that produces the cerebrospinal fluid from the blood and secretes it into the lumen of the brain and spinal chord. GOC:add - GOC:tfm + GOC:tfm JB:jb PMID:9550134 @@ -30009,7 +30250,7 @@ radial glial cells acting as neural progenitors throughout life. Epithelial cells derived from neural plate and neural crest. - GOC:tfm + GOC:tfm @@ -30034,7 +30275,7 @@ radial glial cells acting as neural progenitors throughout life. Cumulus cell is a specialized granulosa cell that surrounds and nourishes the oocyte. This cell-type surrounds the fully-grown oocyte to form a cumulus-oocyte complex (abbr. COC). The terms cumulus oophorus cells, cumulus granulosa cells, cumulus oophorous granulosa cells, granulosa-cumulus cells are used to make a distinction between this cell and the other functionally different subpopulation of granulosa cells at the wall of the Graafian follicle. - GOC:tfm + GOC:tfm http://www.copewithcytokines.org/cope.cgi?key=cumulus%20cells @@ -30282,7 +30523,7 @@ radial glial cells acting as neural progenitors throughout life. An asexual 1-celled spore (primarily for perennation, not dissemination). Originates endogenously and singly within part of a pre-existing cell by the contraction of the protoplast. Possesses an inner secondary and often thickened hyaline or brown wall, usually impregnated with hydrophobic material. - GOC:tfm + GOC:tfm ISBN:085199377X @@ -30375,7 +30616,7 @@ radial glial cells acting as neural progenitors throughout life. A cell of a layer of transitional epithelium in the wall of the bladder, ureter, and renal pelvis, external to the lamina propria. - GOC:tfm + GOC:tfm MA:ma @@ -30476,7 +30717,7 @@ radial glial cells acting as neural progenitors throughout life. Muscle cell which has as its direct parts myofilaments organized into sarcomeres. - GOC:tfm + GOC:tfm ISBN:0721662544 @@ -30548,7 +30789,7 @@ radial glial cells acting as neural progenitors throughout life. An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. GOC:add - GOC:tfm + GOC:tfm ISBN:978-0-323-05290-0 @@ -30744,7 +30985,7 @@ radial glial cells acting as neural progenitors throughout life. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei. GOC:mtg_cardiacconduct_nov11 - GOC:tfm + GOC:tfm ISBN:0323052908 PMID:22426062 PMID:4711263 @@ -30900,7 +31141,7 @@ radial glial cells acting as neural progenitors throughout life. A bipolar neuron found in the retina that is synapsed by rod photoreceptor cells but not by cone photoreceptor cells. These neurons depolarize in response to light. - GOC:tfm + GOC:tfm PMID:14689473 @@ -31289,7 +31530,7 @@ radial glial cells acting as neural progenitors throughout life. A nucleated blood cell involved in coagulation, typically seen in birds and other non-mammalian vertebrates. GOC:add - GOC:tfm + GOC:tfm PMID:16360205 @@ -31356,7 +31597,7 @@ radial glial cells acting as neural progenitors throughout life. A immature or mature cell in the lineage leading to and including erythrocytes. GOC:add - GOC:tfm + GOC:tfm @@ -31665,7 +31906,7 @@ radial glial cells acting as neural progenitors throughout life. GOC:add GOC:amm GOC:dsd - GOC:tfm + GOC:tfm ISBN:0721601464 MESH:D001491 PMCID:PMC2626675 @@ -31853,7 +32094,7 @@ radial glial cells acting as neural progenitors throughout life. A basophil precursor in the granulocytic series, being a cell intermediate in development between a basophilic myelocyte and a band form basophil. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare. Markers are CD11b-positive, CD15-positive, CD16-positive, CD24-positive, CD33-positive, and CD13-positive. - GOC:tfm + GOC:tfm ISBN:0721601464 PMID:18466030 @@ -31997,7 +32238,7 @@ radial glial cells acting as neural progenitors throughout life. GOC:add GOC:amm GOC:dsd - GOC:tfm + GOC:tfm ISBN:0721601464 PMCID:PMC2626675 PMID:10914487 @@ -32193,7 +32434,7 @@ radial glial cells acting as neural progenitors throughout life. A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a eosinophilic myelocyte and a band form eosinophil. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare. Markers are integrin alpha-M-positive, fucosyltransferase FUT4-positive, low affinity immunoglobulin gamma Fc region receptor III-positive, CD33-positive, CD24-positive and aminopeptidase N-negative. GOC:add - GOC:tfm + GOC:tfm ISBN:0721601464 PMID:19622087 @@ -32242,7 +32483,7 @@ radial glial cells acting as neural progenitors throughout life. A late eosinophilic metamyelocyte in which the nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature eosinophil. GOC:add - GOC:tfm + GOC:tfm ISBN:0721601464 PMID:19622087 http://www.cap.org @@ -32312,7 +32553,7 @@ radial glial cells acting as neural progenitors throughout life. Any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes. GOC:add GOC:amm - GOC:tfm + GOC:tfm ISBN:0721601464 @@ -32421,7 +32662,7 @@ radial glial cells acting as neural progenitors throughout life. A tissue-resident macrophage of the renal glomerular mesangium involved in the disposal and degradation of filtration residues, presentation of antigen to T cells and in tissue remodeling. GOC:add - GOC:tfm + GOC:tfm ISBN:0702022918 ISBN:3540536663 PMID:1600140 @@ -32462,7 +32703,7 @@ radial glial cells acting as neural progenitors throughout life. A specialized mononuclear osteoclast associated with the absorption and removal of bone, precursor of multinuclear osteoclasts. GOC:add - GOC:tfm + GOC:tfm PMID:12713016 PMID:15055519 PMID:17380158 @@ -32694,7 +32935,7 @@ radial glial cells acting as neural progenitors throughout life. A phagocyte formed by the fusion of mononuclear phagocytes. GOC:add - GOC:tfm + GOC:tfm @@ -33154,7 +33395,7 @@ radial glial cells acting as neural progenitors throughout life. A T cell that expresses an alpha-beta T cell receptor complex. GOC:add - GOC:tfm + GOC:tfm ISBN:0781735149 @@ -33194,7 +33435,7 @@ radial glial cells acting as neural progenitors throughout life. An alpha-beta T cell that has an immature phenotype and has not completed T cell selection. GOC:add - GOC:tfm + GOC:tfm ISBN:0781735149 @@ -33240,7 +33481,7 @@ radial glial cells acting as neural progenitors throughout life. A alpha-beta T cell that has a mature phenotype. GOC:add - GOC:tfm + GOC:tfm ISBN:0781735149 @@ -33306,7 +33547,7 @@ radial glial cells acting as neural progenitors throughout life. A CD4-positive, CD25-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release. GOC:add - GOC:tfm + GOC:tfm ISBN:0781735149 PMID:19464985 PMID:22343568 @@ -33366,7 +33607,7 @@ radial glial cells acting as neural progenitors throughout life. A CD4-positive, alpha-beta T cell that is found in the columnar epithelium of the gastrointestinal tract. GOC:add - GOC:tfm + GOC:tfm ISBN:0781735149 @@ -33469,7 +33710,7 @@ radial glial cells acting as neural progenitors throughout life. A CD8-positive, alpha-beta T cell that is capable of killing target cells in an antigen specific manner with the phenotype perforin-positive and granzyme B-positive. GOC:add GOC:pam - GOC:tfm + GOC:tfm GO_REF:0000031 ISBN:0781735149 @@ -33520,7 +33761,7 @@ radial glial cells acting as neural progenitors throughout life. A CD8-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release. GOC:add - GOC:tfm + GOC:tfm ISBN:0781735149 @@ -33612,7 +33853,7 @@ radial glial cells acting as neural progenitors throughout life. A mature alpha-beta T cell of the columnar epithelium of the gastrointestinal tract. Intraepithelial T cells often have distinct developmental pathways and activation requirements. GOC:add - GOC:tfm + GOC:tfm ISBN:0781735149 @@ -33660,7 +33901,7 @@ radial glial cells acting as neural progenitors throughout life. A T cell that expresses a gamma-delta T cell receptor complex. GOC:add - GOC:tfm + GOC:tfm ISBN:0781735149 @@ -33762,7 +34003,7 @@ radial glial cells acting as neural progenitors throughout life. A gamma-delta T cell that has a mature phenotype. These cells can be found in tissues and circulation where they express unique TCR repertoire depending on their location. GOC:add - GOC:tfm + GOC:tfm ISBN:0781735149 @@ -33808,7 +34049,7 @@ radial glial cells acting as neural progenitors throughout life. A mature gamma-delta T cell that is found in the columnar epithelium of the gastrointestinal tract. These cells participate in mucosal immune responses. GOC:add - GOC:tfm + GOC:tfm ISBN:0781735149 @@ -33855,7 +34096,7 @@ radial glial cells acting as neural progenitors throughout life. A gamma-delta intraepithelial T cell that has the phenotype CD8-alpha alpha-positive. GOC:add - GOC:tfm + GOC:tfm ISBN:0781735149 @@ -33912,7 +34153,7 @@ radial glial cells acting as neural progenitors throughout life. A gamma-delta intraepithelial T cell that has the phenotype CD4-negative and CD8-negative. GOC:add - GOC:tfm + GOC:tfm ISBN:0781735149 @@ -34016,7 +34257,7 @@ radial glial cells acting as neural progenitors throughout life. A thymocyte that has the phenotype CD4-negative, CD8-positive, CD44-negative, CD25-negative, and pre-TCR-positive. GOC:add - GOC:tfm + GOC:tfm GO_REF:0000031 ISBN:0781735149 http://www.immgen.org/index_content.html @@ -34088,7 +34329,7 @@ radial glial cells acting as neural progenitors throughout life. A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-positive. GOC:add - GOC:tfm + GOC:tfm GO_REF:0000031 ISBN:0781735149 @@ -34169,7 +34410,7 @@ radial glial cells acting as neural progenitors throughout life. A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, and CD25-positive and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain. GOC:add - GOC:tfm + GOC:tfm GO_REF:0000031 ISBN:0781735149 @@ -34249,7 +34490,7 @@ radial glial cells acting as neural progenitors throughout life. A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive. GOC:add - GOC:tfm + GOC:tfm GO_REF:0000031 ISBN:0781735149 @@ -34318,7 +34559,7 @@ radial glial cells acting as neural progenitors throughout life. A thymocyte expressing the alpha-beta T cell receptor complex as well as both the CD4 and CD8 coreceptors. GOC:add - GOC:tfm + GOC:tfm GO_REF:0000031 ISBN:0781735149 @@ -34386,7 +34627,7 @@ radial glial cells acting as neural progenitors throughout life. An immature alpha-beta T cell that is located in the thymus and is CD4-positive and CD8-negative. GOC:add - GOC:tfm + GOC:tfm GO_REF:0000031 ISBN:0781735149 @@ -34455,7 +34696,7 @@ radial glial cells acting as neural progenitors throughout life. An immature alpha-beta T cell that is located in the thymus and is CD8-positive and CD4-negative. GOC:add - GOC:tfm + GOC:tfm GO_REF:0000031 ISBN:0781735149 @@ -34518,7 +34759,7 @@ radial glial cells acting as neural progenitors throughout life. A long-lived, antigen-experienced T cell that has acquired a memory phenotype including distinct surface markers and the ability to differentiate into an effector T cell upon antigen reexposure. GOC:add GOC:pam - GOC:tfm + GOC:tfm GO_REF:0000031 ISBN:0781735149 @@ -34735,7 +34976,7 @@ radial glial cells acting as neural progenitors throughout life. GOC:add GOC:dsd GOC:rhs - GOC:tfm + GOC:tfm GO_REF:0000031 ISBN:0781735149 PMID:20081059 @@ -34800,7 +35041,7 @@ radial glial cells acting as neural progenitors throughout life. A precursor B cell is a B cell with the phenotype CD10-positive. GOC:rhs - GOC:tfm + GOC:tfm GO_REF:0000031 @@ -35164,7 +35405,7 @@ radial glial cells acting as neural progenitors throughout life. A conventional B cell subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells. These cells are CD43-negative. GOC:add GOC:dsd - GOC:tfm + GOC:tfm ISBN:0781735149 PMID:11861604 PMID:20933013 @@ -35585,7 +35826,7 @@ radial glial cells acting as neural progenitors throughout life. A progenitor cell of the thrombocyte, a nucleated blood cell involved in coagulation typically seen in birds and other non-mammalian vertebrates. GOC:add - GOC:tfm + GOC:tfm PMID:7758949 @@ -36113,7 +36354,7 @@ radial glial cells acting as neural progenitors throughout life. A progenitor cell of the neutrophil lineage. GOC:add - GOC:tfm + GOC:tfm ISBN:0721601464 @@ -36321,7 +36562,7 @@ radial glial cells acting as neural progenitors throughout life. A precursor in the granulocytic series, being a cell intermediate in development between a myeloblast and myelocyte, that has distinct nucleoli, a nuclear-to-cytoplasmic ratio of 5:1 to 3:1, and containing a few primary cytoplasmic granules. Markers for this cell are fucosyltransferase FUT4-positive, CD33-positive, integrin alpha-M-negative, low affinity immunoglobulin gamma Fc region receptor III-negative, and CD24-negative. GOC:add GOC:amm - GOC:tfm + GOC:tfm ISBN:0721601464 http://www.cap.org @@ -36510,7 +36751,7 @@ radial glial cells acting as neural progenitors throughout life. A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans. GOC:add - GOC:tfm + GOC:tfm PMID:19022770 @@ -36559,7 +36800,7 @@ radial glial cells acting as neural progenitors throughout life. A progenitor cell restricted to the lymphoid lineage. GOC:add - GOC:tfm + GOC:tfm @@ -36606,7 +36847,7 @@ radial glial cells acting as neural progenitors throughout life. A progenitor cell restricted to the myeloid lineage. GOC:add - GOC:tfm + GOC:tfm PMID:19022770 @@ -36676,7 +36917,7 @@ radial glial cells acting as neural progenitors throughout life. An immature cell of the conventional dendritic cell lineage, characterized by high levels of antigen uptake via endocytosis, macropinocytosis, and phagocytosis, and typically found resident in the tissues. Markers for this cell are CD80-low, CD86-low, and MHC-II-low. GOC:add - GOC:tfm + GOC:tfm PMID:9521319 @@ -36758,7 +36999,7 @@ radial glial cells acting as neural progenitors throughout life. A mature cell of the conventional dendritic cell lineage, characterized by a high capacity for antigen presentation and typically found in a lymph node. GOC:add - GOC:tfm + GOC:tfm PMID:9521319 @@ -36974,7 +37215,7 @@ radial glial cells acting as neural progenitors throughout life. A rapidly cycling mature B cell that has distinct phenotypic characteristics and is involved in T-dependent immune responses and located typically in the germinal centers of lymph nodes. This cell type expresses Ly77 after activation. GOC:add GOC:dsd - GOC:tfm + GOC:tfm ISBN:0781735149 PMID:19447676 PMID:20933013 @@ -37301,7 +37542,7 @@ radial glial cells acting as neural progenitors throughout life. Olfactory epithelial support cell is a columnar cell that extends from the epithelial free margin to the basement membrane of the olfactory epithelium. This cell type has a large, vertically, elongate, euchromatic nucleus, along with other nuclei, forms a layer superficial to the cell body of the receptor cell; sends long somewhat irregular microvilli into the mucus layer; at the base, with expanded end-feet containing numerous lamellated dense bodies resembling lipofuscin of neurons. - GOC:tfm + GOC:tfm ISBN:0517223651 SANBI:mhl @@ -37633,7 +37874,7 @@ radial glial cells acting as neural progenitors throughout life. A macrophage which develops from an inflammatory monocyte and is recruited into the tissues in response to injury and infection as part of an inflammatory response. Markers include CD11b-positive, CD68-positive, and F4/80-positive. GOC:add GOC:ana - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:15771589 @@ -37677,7 +37918,7 @@ radial glial cells acting as neural progenitors throughout life. A macrophage that suppresses immune responses. GOC:add - GOC:tfm + GOC:tfm PMID:20402419 @@ -37857,7 +38098,7 @@ radial glial cells acting as neural progenitors throughout life. A gut-associated lymphoid tissue macrophage found in lamina propria of the gut. GOC:ana - GOC:tfm + GOC:tfm GO_REF:0000031 https://orcid.org/0000-0002-2825-0621 @@ -37911,7 +38152,7 @@ radial glial cells acting as neural progenitors throughout life. A tissue-resident macrophage resident found in the thymus, involved in the clearance of apoptotic thymocytes. GOC:ana - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:9048205 @@ -37931,7 +38172,7 @@ radial glial cells acting as neural progenitors throughout life. A tissue-resident macrophage found in a secondary lymphoid organ. GOC:ana - GOC:tfm + GOC:tfm GO_REF:0000031 @@ -38005,7 +38246,7 @@ radial glial cells acting as neural progenitors throughout life. A secondary lymphoid organ macrophage found in a lymph node. This cell is CD169-high. GOC:ana - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:11971865 @@ -38094,7 +38335,7 @@ radial glial cells acting as neural progenitors throughout life. A gut-associated lymphoid tissue macrophage found in the Peyer's patches. GOC:ana - GOC:tfm + GOC:tfm GO_REF:0000031 @@ -38685,7 +38926,7 @@ radial glial cells acting as neural progenitors throughout life. A splenic white pulp macrophage found in and around the germinal centers of the white pulp of the spleen that participates in phagocytosis of apoptotic B cells from the germinal centers. A marker for a cell of this type is Mertk-positive. GOC:ana - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:19631584 @@ -38905,7 +39146,7 @@ radial glial cells acting as neural progenitors throughout life. A central nervous system macrophage found in small blood vessels in the brain. Markers include CD14+CD16+CD163+. - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:16507898 @@ -38990,7 +39231,7 @@ radial glial cells acting as neural progenitors throughout life. A thymic macrophage found in the thymic cortex. GOC:ana - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:9048205 @@ -39033,7 +39274,7 @@ radial glial cells acting as neural progenitors throughout life. A tissue-resident macrophage found in the mucosa associated lymphoid tissue. GOC:ana - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:19906191 @@ -39199,7 +39440,7 @@ radial glial cells acting as neural progenitors throughout life. A lymph node macrophage found in the subcapsular sinus of lymph nodes that participates in sensing, clearance, and antigen presentation of lymph-borne particulate antigens. This macrophage is capable of activating invaraint NKT cells and is CD169-positive. - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:14668803 PMID:17934446 @@ -39264,7 +39505,7 @@ radial glial cells acting as neural progenitors throughout life. A lymph node macrophage found in the cortex of lymph nodes, in particular in and around the germinal centers, and that participates in phagocytosis of apoptotic B cells from the germinal centers. GOC:ana - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:19631584 @@ -39395,7 +39636,7 @@ radial glial cells acting as neural progenitors throughout life. An elicited macrophage characterized by low production of pro-inflammatory and Th1 polarizing cytokines and high expression of arginase-1, and associated with tissue remodelling. GOC:ana - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:20510870 @@ -39493,7 +39734,7 @@ radial glial cells acting as neural progenitors throughout life. An immature T cell located in the thymus. GOC:add - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:12415312 @@ -39589,7 +39830,7 @@ radial glial cells acting as neural progenitors throughout life. A pro-T cell that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative. GOC:add - GOC:tfm + GOC:tfm GO_REF:0000031 @@ -39665,7 +39906,7 @@ radial glial cells acting as neural progenitors throughout life. An antigen inexperienced CD4-positive, alpha-beta T cell with the phenotype CCR7-positive, CD127-positive and CD62L-positive. This cell type develops in the thymus. This cell type is also described as being CD25-negative, CD62L-high, and CD44-low. GOC:add - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:19100699 PMID:22343568 @@ -39681,7 +39922,7 @@ radial glial cells acting as neural progenitors throughout life. Th0 - GOC:tfm + GOC:tfm @@ -39895,7 +40136,7 @@ radial glial cells acting as neural progenitors throughout life. Mature T cell not yet exposed to antigen with the phenotype CCR7-positive, CD45RA-positive, and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low. GOC:add GOC:pam - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:19100699 @@ -40063,7 +40304,7 @@ radial glial cells acting as neural progenitors throughout life. A CD8-positive, alpha-beta T cell that has not experienced activation via antigen contact and has the phenotype CD45RA-positive, CCR7-positive and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low. GOC:add - GOC:tfm + GOC:tfm GO_REF:0000031 ISBN:0781735149 PMID:22343568 @@ -40191,7 +40432,7 @@ radial glial cells acting as neural progenitors throughout life. CD4-positive alpha-beta T cell with the phenotype CD25-positive, CTLA-4-positive, and FoxP3-positive with regulatory function. GOC:add GOC:pam - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:19464985 @@ -40271,7 +40512,7 @@ radial glial cells acting as neural progenitors throughout life. CD4-positive alpha-beta T cell with the phenotype FoxP3-positive, CD25-positive, CD62L-positive, and CTLA-4 positive with regulatory function. GOC:add GOC:pam - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:19464985 @@ -40410,7 +40651,7 @@ radial glial cells acting as neural progenitors throughout life. CD4-positive, alpha-beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative. GOC:add GOC:pam - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:22343568 @@ -40509,7 +40750,7 @@ radial glial cells acting as neural progenitors throughout life. A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, CD25-positive, and CCR7-negative. GOC:add GOC:pam - GOC:tfm + GOC:tfm GO_REF:0000031 @@ -40575,7 +40816,7 @@ radial glial cells acting as neural progenitors throughout life. CD8-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative. GOC:add GOC:pam - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:20146720 PMID:22343568 @@ -40685,7 +40926,7 @@ radial glial cells acting as neural progenitors throughout life. A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive, that secretes cytokines. GOC:add GOC:pam - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:20146720 @@ -40778,7 +41019,7 @@ radial glial cells acting as neural progenitors throughout life. A mature T cell that differentiated and acquired cytotoxic function with the phenotype perforin-positive and granzyme-B positive. GOC:add GOC:pam - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:18395547 @@ -40838,7 +41079,7 @@ radial glial cells acting as neural progenitors throughout life. A differentiated T cell with ability to traffic to peripheral tissues and is capable of mounting a specific immune response. GOC:PAM-ADD - GOC:tfm + GOC:tfm ISBN:0877799148 PMID:18395547 @@ -40887,7 +41128,7 @@ radial glial cells acting as neural progenitors throughout life. A effector T cell that provides help in the form of secreted cytokines to other immune cells. GOC:add GOC:pam - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:18395547 @@ -41014,7 +41255,7 @@ radial glial cells acting as neural progenitors throughout life. An immature alpha-beta T-cell that express Egr2. These cells give rise to T cells expressing NK markers. GOC:add GOC:pam - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:17589542 PMID:19169262 @@ -41152,7 +41393,7 @@ radial glial cells acting as neural progenitors throughout life. A mature gamma-delta T cell located in the epidermis that regulates wound healing. GOC:add GOC:pam - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:11976459 @@ -41329,7 +41570,7 @@ radial glial cells acting as neural progenitors throughout life. A CD8-positive, alpha-beta positive T cell expressing GATA-3 and secreting IL-4. GOC:add GOC:pam - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:9914231 @@ -41399,7 +41640,7 @@ radial glial cells acting as neural progenitors throughout life. A CD8-positive alpha beta-positive T cell with the phenotype FoxP3-positive and having suppressor function. GOC:add GOC:pam - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:19118505 @@ -41470,7 +41711,7 @@ radial glial cells acting as neural progenitors throughout life. CD8-positive, alpha-beta positive regulatory T cell with the phenotype CD28-negative and FoxP3-positive. GOC:add GOC:pam - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:19118505 @@ -41521,7 +41762,7 @@ radial glial cells acting as neural progenitors throughout life. An alpha-beta T cell expressing NK cell markers that is CD1d restricted and expresses specific V-alpha chains. NK T cells of this type recognize the glycolipid alpha-galactosylceramide in the context of CD1d. GOC:add GOC:pam - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:15039760 @@ -41569,7 +41810,7 @@ radial glial cells acting as neural progenitors throughout life. An alpha-beta T cell expressing NK call markers that is CD1d restricted and expresses a diverse TCR repertoire. Type II NKT cells do not become activated by alpha-galactosylceramide when presented by CD1d. GOC:add GOC:pam - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:15039760 @@ -41618,7 +41859,7 @@ radial glial cells acting as neural progenitors throughout life. A type I NK T cell that has the phenotype CD4-positive. GOC:add GOC:pam - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:17303398 @@ -41677,7 +41918,7 @@ radial glial cells acting as neural progenitors throughout life. A type I NK T cell that has the phenotype CD4-negative and CD8-negative. GOC:add GOC:pam - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:18997862 @@ -41749,7 +41990,7 @@ radial glial cells acting as neural progenitors throughout life. A type I NK T cell that has been recently activated, secretes interferon-gamma and IL-4, and has the phenotype CD4-positive, CD69-positive, and downregulated NK markers. GOC:add GOC:pam - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:17303398 @@ -41812,7 +42053,7 @@ radial glial cells acting as neural progenitors throughout life. A mature NK T cell that secretes interferon-gamma and enhances type 1 immune responses. GOC:add GOC:pam - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:17303398 @@ -41885,7 +42126,7 @@ radial glial cells acting as neural progenitors throughout life. A mature NK T cell that predominantly secretes type 2 cytokines such as interleukin-4 and interleukin-13 and enhances type 2 immune responses. GOC:add GOC:pam - GOC:tfm + GOC:tfm GO_REF:0000031 @@ -41950,7 +42191,7 @@ radial glial cells acting as neural progenitors throughout life. A type I NK T cell that has been recently activated, secretes interferon-gamma and interleukin-4, and has phenotype CD4-negative, CD8-negative, CD69-positive, and downregulated NK markers. GOC:add GOC:pam - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:17303398 @@ -42017,7 +42258,7 @@ radial glial cells acting as neural progenitors throughout life. A mature NK T cell that secretes interferon-gamma and enhances Th1 immune responses. GOC:add GOC:pam - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:17303398 @@ -42084,7 +42325,7 @@ radial glial cells acting as neural progenitors throughout life. A mature NK T cell that secretes interleukin-4 and enhances Th2 immune responses. GOC:add GOC:pam - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:17303398 @@ -42142,7 +42383,7 @@ radial glial cells acting as neural progenitors throughout life. A type II NK T cell that has been recently activated, secretes interferon-gamma and interleukin-4, and has the phenotype CD69-positive and downregulated NK markers. GOC:add GOC:pam - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:17964217 @@ -42271,7 +42512,7 @@ radial glial cells acting as neural progenitors throughout life. A type II NK T cell that has been recently activated, secretes interleukin-4, and has the phenotype CD69-positive and downregulated NK markers. GOC:add GOC:pam - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:17964217 @@ -42334,7 +42575,7 @@ radial glial cells acting as neural progenitors throughout life. A CD4-positive, alpha-beta T cell that has cytotoxic function. GOC:add GOC:pam - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:18440213 @@ -42491,7 +42732,7 @@ radial glial cells acting as neural progenitors throughout life. GOC:add GOC:dsd GOC:pam - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:19022770 @@ -42558,7 +42799,7 @@ radial glial cells acting as neural progenitors throughout life. GOC:add GOC:dsd GOC:pam - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:16551251 PMID:17100874 @@ -42646,7 +42887,7 @@ radial glial cells acting as neural progenitors throughout life. NK cell that has the phenotype CD56-bright, CD16-negative, and CD84-positive with the function to secrete interferon-gamma but is not cytotoxic. GOC:add GOC:pam - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:19796267 PMID:22343568 @@ -42817,7 +43058,7 @@ radial glial cells acting as neural progenitors throughout life. An alpha-beta T cell that is found in the lamina propria of mucosal tissues and is restricted by the MR-1 molecule. GOC:add GOC:pam - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:19416870 @@ -42967,7 +43208,7 @@ radial glial cells acting as neural progenitors throughout life. A plasmacytoid dendritic cell developing in the thymus with phenotype CD11c-negative or low, CD45RA-positive, CD11b-negative, and CD123-positive. GOC:add GOC:pam - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:19941119 @@ -43044,7 +43285,7 @@ radial glial cells acting as neural progenitors throughout life. A Be cell that facilitates development of T-helper 1 (Th1) phenotype in CD4-positive T cells, and secretes high levels of interleukin-2, tumor necrosis factor-alpha and interferon-gamma. GOC:dsd GOC:msz - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:11101868 PMID:20224569 @@ -43139,7 +43380,7 @@ radial glial cells acting as neural progenitors throughout life. A Be cell that facilitates development of T-helper 2 (Th2) phenotype T cells, and secretes high levels of interleukin-2, interleukin-10, interleukin-4, and interleukin-6. GOC:dsd GOC:msz - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:11101868 PMID:20224569 @@ -43181,7 +43422,7 @@ radial glial cells acting as neural progenitors throughout life. A lymphocyte of B lineage with the commitment to express an immunoglobulin complex. GOC:add GOC:rhs - GOC:tfm + GOC:tfm GO_REF:0000031 ISBN:0781735149 @@ -43224,7 +43465,7 @@ radial glial cells acting as neural progenitors throughout life. A lymphocyte of B lineage that is devoted to secreting large amounts of immunoglobulin. GOC:add - GOC:tfm + GOC:tfm GO_REF:0000031 ISBN:0721601464 ISBN:0781735149 @@ -43513,7 +43754,7 @@ radial glial cells acting as neural progenitors throughout life. An preBRC-positive large pre-B-II cell is a large pre-B-II cell that is pre-B cell receptor-positive, composed of surrogate light chain protein (SL), which is composed of VpreB , Lambda 5/14.1, in complex with immunoglobulin mu heavy chain (IgHmu) on the cell surface. GOC:rhs - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:9785673 @@ -43586,7 +43827,7 @@ radial glial cells acting as neural progenitors throughout life. A pre-BCR-negative large pre-B-II cell is a large pre-B-II cell that is pre-B cell receptor-negative, composed of surrogate light chain protein (SL), which is composed of VpreB and Lambda 5/14.1, in complex with immunoglobulin mu heavy chain (IgHmu), on the cell surface, and lack a DNA rearrangement of immunoglobulin light chain genes. GOC:rhs - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:9785673 @@ -43672,7 +43913,7 @@ radial glial cells acting as neural progenitors throughout life. A small pre-B-II cell is a pre-B-II cell that is Rag1-positive, Rag2-positive, pre-BCR-negative, and BCR-negative, is not proliferating, and carries a DNA rearrangement of one or more immunoglobulin light chain genes. GOC:dsd GOC:rhs - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:16551251 PMID:18432934 @@ -43744,7 +43985,7 @@ radial glial cells acting as neural progenitors throughout life. A pre-B-II cell is a precursor B cell that expresses immunoglobulin mu heavy chain (IgHmu+), and lack expression of CD34, TdT, immunoglobulin kappa light chain and immunoglobulin lambda light chain. GOC:dsd GOC:rhs - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:9785673 @@ -43851,7 +44092,7 @@ radial glial cells acting as neural progenitors throughout life. A pre-B-I cell is a precursor B cell that expresses CD34 and surrogate immunoglobulin light chain (VpreB , Lambda 5 (mouse)/14.1 (human)) on the cell surface, and TdT, Rag1,and Rag2 intracellularly. Cell type carries a D-JH DNA rearrangement, and lacks expression of immunglobulin heavy chain protein. GOC:dsd GOC:rhs - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:16551251 PMID:18432934 @@ -44023,7 +44264,7 @@ radial glial cells acting as neural progenitors throughout life. A transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen. This cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative, and CD93-positive. This cell type has also been described as IgM-high, CD19-positive, B220-positive, AA4-positive, and CD23-negative. GOC:dsd GOC:msz - GOC:tfm + GOC:tfm GO_REF:0000031 PMCID:PMC2193793 PMID:12810111 @@ -44123,7 +44364,7 @@ radial glial cells acting as neural progenitors throughout life. A transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, CD93-positive and is located in the splenic B follicles. This cell type has also been described as IgM-high, CD19-positive, B220-positive, AA4-positive, and CD23-positive. GOC:dsd GOC:msz - GOC:tfm + GOC:tfm GO_REF:0000031 PMCID:PMC2193793 PMID:12810111 @@ -44222,7 +44463,7 @@ radial glial cells acting as neural progenitors throughout life. A transitional stage B cell that expresses surface IgM and IgD, and CD62L. This cell type appears to be an anergic B cell that does not proliferate upon BCR signaling, is found in the spleen and lymph nodes, and has the phenotype surface IgM-positive, surface IgD-positive, CD21-positive, CD23-positive, CD62L-positive, and CD93-positive. This cell type has also been described as IgM-low, CD19-positive, B220-positive, AA4-positive, and CD23-positive (i.e. this cell-type is distinguished from T2 cells by surface expression of IgM). GOC:msz - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:12810111 PMID:17174121 @@ -44430,7 +44671,7 @@ radial glial cells acting as neural progenitors throughout life. A germinal center B cell that develops from a Bm3 B cell. This cell has the phenotype IgM-negative, IgD-positive, and CD38-positive. GOC:add GOC:msz - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:9280752 @@ -44516,7 +44757,7 @@ radial glial cells acting as neural progenitors throughout life. A germinal center B cell that founds a germinal center, and has the phenotype IgD-positive, CD38-positive, and CD23-negative. GOC:dsd GOC:msz - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:17992590 PMID:18432934 @@ -44762,7 +45003,7 @@ radial glial cells acting as neural progenitors throughout life. A memory B cell arising in the germinal center that is IgD-negative and has undergone somatic mutation of the variable region of the immunoglobulin heavy and light chain genes. GOC:dsd GOC:msz - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:18432934 PMID:8006591 @@ -44831,7 +45072,7 @@ radial glial cells acting as neural progenitors throughout life. A mature B cell that produces cytokines that can influence CD4 T cell differentiation. GOC:msz - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:11101868 PMID:20224569 @@ -44913,7 +45154,7 @@ radial glial cells acting as neural progenitors throughout life. A mature B cell that has the phenotype CD1d-positive and expresses interleukin-10. This cell type has been associated with suppression of chronic inflammatory responses and T cell responses. GOC:dsd GOC:msz - GOC:tfm + GOC:tfm GO_REF:0000031 MESH:D060151 PMID:11869683 @@ -45309,7 +45550,7 @@ radial glial cells acting as neural progenitors throughout life. A fully differentiated plasma cell that lives for years, as opposed to months, secretes immunoglobulin, and has the phenotype weakly CD19-positive, CD20-negative, CD38-negative, strongly CD138-positive, MHC Class II-negative, surface immunoglobulin-negative, IgD-negative, and strongly CXCR4-positive. The majority of these cells of this type reside in the bone marrow. GOC:msz - GOC:tfm + GOC:tfm GO_REF:0000031 ISBN:9780781765190 PMID:16014527 @@ -45616,7 +45857,7 @@ radial glial cells acting as neural progenitors throughout life. An activated mature (naive or memory) B cell that is secreting immunoglobulin, typified by being CD27-positive, CD38-positive, CD138-negative. GOC:dsd GOC:msz - GOC:tfm + GOC:tfm GO_REF:0000031 PMCID:PMC2673126 @@ -45664,7 +45905,7 @@ radial glial cells acting as neural progenitors throughout life. A memory B cell with the phenotype IgD-negative and CD27-negative. GOC:msz - GOC:tfm + GOC:tfm GO_REF:0000031 @@ -46509,7 +46750,7 @@ radial glial cells acting as neural progenitors throughout life. Immature CD8_alpha-negative CD11b-positive dendritic cell is a CD8_alpha-negative CD11b-positive dendritic cell that is CD80-low, CD86-low, and MHCII-low. GOC:amm - GOC:tfm + GOC:tfm GO_REF:0000031 PMCID:PMC2346585 @@ -46682,7 +46923,7 @@ radial glial cells acting as neural progenitors throughout life. CD8_alpha-negative CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-positive and is CD205-negative and CD8_alpha-negative. GOC:amm - GOC:tfm + GOC:tfm GO_REF:0000031 PMCID:PMC2346585 @@ -46788,7 +47029,7 @@ radial glial cells acting as neural progenitors throughout life. CD8_alpha-positive CD11b-negative dendritic cell is a conventional dendritic cell that is CD11b-negative, CD4-negative and is CD205-positive and CD8_alpha-positive. GOC:amm - GOC:tfm + GOC:tfm GO_REF:0000031 PMCID:PMC2346585 @@ -46895,7 +47136,7 @@ radial glial cells acting as neural progenitors throughout life. Mature CD8_alpha-negative CD11b-negative dendritic cell is a CD8_alpha-negative CD11b-negative dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive. GOC:amm - GOC:tfm + GOC:tfm GO_REF:0000031 PMCID:PMC2346585 @@ -46952,7 +47193,7 @@ radial glial cells acting as neural progenitors throughout life. Mature CD8_alpha-negative CD11b-positive dendritic cell is a CD8_alpha-negative CD11b-positive dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive. GOC:amm - GOC:tfm + GOC:tfm GO_REF:0000031 PMCID:PMC2346585 @@ -46999,7 +47240,7 @@ radial glial cells acting as neural progenitors throughout life. Immature CD8_alpha-positive CD11b-negative dendritic cell is a CD8_alpha-positive CD11b-negative dendritic cell that is CD80-low, CD86-low, and MHCII-low. GOC:amm - GOC:tfm + GOC:tfm GO_REF:0000031 PMCID:PMC2346585 @@ -47318,7 +47559,7 @@ radial glial cells acting as neural progenitors throughout life. A hematopoietic stem cell that has plasma membrane part Kit-positive, SCA-1-positive, CD150-positive and CD34-negative. GOC:add GOC:amm - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:17952047 PMID:19022770 @@ -47468,7 +47709,7 @@ radial glial cells acting as neural progenitors throughout life. Immature interstitial dendritic cell is a interstitial dendritic cell that is CD80-low, CD86-low, and MHCII-low. GOC:amm - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:17850486 @@ -47544,7 +47785,7 @@ radial glial cells acting as neural progenitors throughout life. Mature interstitial dendritic cell is a interstitial dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive. GOC:amm - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:17850486 @@ -47698,7 +47939,7 @@ radial glial cells acting as neural progenitors throughout life. Immature CD1a-positive Langerhans cell is a CD1a-positive Langerhans cell that is CD80-low, CD86-low, and MHCII-low. GOC:amm - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:17850486 @@ -47755,7 +47996,7 @@ radial glial cells acting as neural progenitors throughout life. Mature CD1a-positive Langerhans cell is a CD1a-positive Langerhans cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive. GOC:amm - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:17850486 @@ -47802,7 +48043,7 @@ radial glial cells acting as neural progenitors throughout life. Immature CD8_alpha-low Langerhans cell is a CD8_alpha-low Langerhans cell that is CD80-low, CD86-low, and MHCII-low. GOC:amm - GOC:tfm + GOC:tfm GO_REF:0000031 PMCID:PMC2346585 @@ -47963,7 +48204,7 @@ radial glial cells acting as neural progenitors throughout life. A common lymphoid progenitor that is CD10-positive, CD45RA-positive, CD34-positive and CD38-positive. GOC:add GOC:amm - GOC:tfm + GOC:tfm GO_REF:0000031 PMCID:PMC2346585 PMID:19022770 @@ -48120,7 +48361,7 @@ radial glial cells acting as neural progenitors throughout life. A common myeloid progenitor that is Kit-positive and CD34-positive, Il7ra-negative, and is SCA1-low and Fcgr2-low and Fcgr3-low. GOC:add GOC:amm - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:1261582 PMID:17952047 @@ -48244,7 +48485,7 @@ radial glial cells acting as neural progenitors throughout life. CD133-positive hematopoietic stem cell is a hematopoietic stem cell that is CD34-positive, CD90-positive, and CD133-positive. GOC:add GOC:amm - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:10430905 PMID:11750107 @@ -48369,7 +48610,7 @@ radial glial cells acting as neural progenitors throughout life. A common lymphoid progenitor that is Kit-low, FLT3-positive, IL7ralpha-positive, and SCA1-low. GOC:add GOC:amm - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:17952047 http://www.immgen.org/index_content.html @@ -48609,7 +48850,7 @@ radial glial cells acting as neural progenitors throughout life. CD7-positive lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-positive and is CD45RA-negative. GOC:amm - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:16551251 PMID:19491395 @@ -48798,7 +49039,7 @@ radial glial cells acting as neural progenitors throughout life. Common dendritic precursor is a hematopoietic progenitor cell that is CD117-low, CD135-positive, CD115-positive and lacks plasma membrane parts for hematopoietic lineage markers. GOC:amm - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:16551251 PMID:17922016 @@ -50139,7 +50380,7 @@ radial glial cells acting as neural progenitors throughout life. A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. These cells are CD34-positive, and express Gata1, Gata2, C/EBPa, and Pu.1. GOC:add GOC:dsd - GOC:tfm + GOC:tfm ISBN:0878932437 PMCID:PMC2212039 PMID:10724173 @@ -50336,7 +50577,7 @@ radial glial cells acting as neural progenitors throughout life. A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers. - GOC:tfm + GOC:tfm PMID:19022770 @@ -51891,7 +52132,7 @@ radial glial cells acting as neural progenitors throughout life. A CD8-positive, alpha-beta T cell with memory phenotype indicated by being CD45RO and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high. - GOC:tfm + GOC:tfm GO_REF:0000031 PMID:20146720 @@ -51997,7 +52238,7 @@ radial glial cells acting as neural progenitors throughout life. CD4-positive, alpha-beta long-lived T cell with the phenotype CD45RO-positive and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high. GOC:add - GOC:tfm + GOC:tfm GO_REF:0000031 ISBN:0781735149 http://www.immgen.org/index_content.html @@ -52133,7 +52374,7 @@ radial glial cells acting as neural progenitors throughout life. An erythroid progenitor cell is Kit-positive, Ly6A-negative, CD41-negative, CD127-negative, and CD123-negative. This cell type is also described as being lin-negative, Kit-positive, CD150-negative, CD41-negative, CD105-positive, and FcgR-negative. GOC:ak - GOC:tfm + GOC:tfm PMID:19805084 http://www.immgen.org/index_content.html @@ -52198,7 +52439,7 @@ radial glial cells acting as neural progenitors throughout life. A granulocyte monocyte progenitor is CD34-positive, CD38-positive, IL-3receptor-alpha-positive and is CD45RA-negative. - GOC:tfm + GOC:tfm PMID:12615892 PMID:19022770 @@ -52319,7 +52560,7 @@ radial glial cells acting as neural progenitors throughout life. A granulocyte monocyte progenitor that is Kit-positive, CD34-positive, Fc-gamma receptor II/II-positive, and is Sca-1-negative, Il7ra-negative, Cxc3r1-negative, and CD90-negative. - GOC:tfm + GOC:tfm PMID:12615892 PMID:16322423 PMID:19022770 @@ -52385,7 +52626,7 @@ radial glial cells acting as neural progenitors throughout life. An erythroid progenitor cell that is CD34-positive and is GlyA-negative. GOC:ak - GOC:tfm + GOC:tfm PMID:19621348 @@ -52446,7 +52687,7 @@ radial glial cells acting as neural progenitors throughout life. A proerythoblast that is CD34-negative and GlyA-negative. GOC:ak - GOC:tfm + GOC:tfm PMID:19621348 @@ -52520,7 +52761,7 @@ radial glial cells acting as neural progenitors throughout life. A megakaryocyte erythroid progenitor cell is CD34-positive, CD38-positive and is IL3-receptor alpha-negative and CD45RA-negative. - GOC:tfm + GOC:tfm PMID:12615892 PMID:190227700 @@ -52625,7 +52866,7 @@ radial glial cells acting as neural progenitors throughout life. A megakaryocyte erythroid progenitor cell that is Kit-positive and is Sca1-negative, CD34-negative, CD90-negative, IL7r-alpha-negative and Fcgr II/III-low. - GOC:tfm + GOC:tfm PMID:12615892 PMID:19022770 http://www.immgen.org/index_content.html @@ -52695,7 +52936,7 @@ radial glial cells acting as neural progenitors throughout life. A lineage marker-negative, CD34-positive, IL5r-alpha-positive, and Sca1-negative eosinophil progenitor cell. - GOC:tfm + GOC:tfm PMID:17582345 @@ -52753,7 +52994,7 @@ radial glial cells acting as neural progenitors throughout life. A lineage marker-negative, CD34-positive, CD38-positive, IL3r-alpha-positive, IL5r-alpha-positive, and CD45RA-negative eosinophil progenitor cell. - GOC:tfm + GOC:tfm PMCID:PMC2626675 @@ -52815,7 +53056,7 @@ radial glial cells acting as neural progenitors throughout life. A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages. - GOC:tfm + GOC:tfm PMID:19273628 @@ -53015,7 +53256,7 @@ radial glial cells acting as neural progenitors throughout life. A lin-negative, MHC-II-negative, CD11c-positive, FLT3-positive cell with intermediate expression of SIRP-alpha. - GOC:tfm + GOC:tfm @@ -53095,7 +53336,7 @@ radial glial cells acting as neural progenitors throughout life. A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages. Marker for this cell is Kit-high, CD115-positive, CD135-positive, Cx3cr1-positive, and is Il7ra-negative. - GOC:tfm + GOC:tfm PMID:19273628 @@ -53186,7 +53427,7 @@ radial glial cells acting as neural progenitors throughout life. A proerythoblast that is Kit-low, Lyg76-positive, and CD71-positive. GOC:ak - GOC:tfm + GOC:tfm PMID:19805084 @@ -53247,7 +53488,7 @@ radial glial cells acting as neural progenitors throughout life. A basophilic erythroblast that is GlyA-positive. GOC:ak - GOC:tfm + GOC:tfm PMID:1638021 @@ -53328,7 +53569,7 @@ radial glial cells acting as neural progenitors throughout life. A basophilic erythroblast that is Lyg 76-high and is Kit-negative. GOC:ak - GOC:tfm + GOC:tfm PMID:19805084 @@ -53409,7 +53650,7 @@ radial glial cells acting as neural progenitors throughout life. A polychromatophilic erythroblast that is Lyg 76-high and is Kit-negative. GOC:ak - GOC:tfm + GOC:tfm PMID:19805084 @@ -53470,7 +53711,7 @@ radial glial cells acting as neural progenitors throughout life. A polychromatiic erythroblast that is Gly-A-positive and CD71-low. GOC:ak - GOC:tfm + GOC:tfm PMID:1638021 @@ -53561,7 +53802,7 @@ radial glial cells acting as neural progenitors throughout life. An orthochromatophilic erythroblast that is ter119-high, CD71-low, and Kit-negative. GOC:ak - GOC:tfm + GOC:tfm PMID:19805084 @@ -53622,7 +53863,7 @@ radial glial cells acting as neural progenitors throughout life. An erythroblast that is GlyA-positive and CD71-negative. GOC:ak - GOC:tfm + GOC:tfm PMID:1638021 @@ -53673,7 +53914,7 @@ radial glial cells acting as neural progenitors throughout life. A reticulocyte that is Ly76-high and is Kit-negative. GOC:ak - GOC:tfm + GOC:tfm PMID:18539294 @@ -53724,7 +53965,7 @@ radial glial cells acting as neural progenitors throughout life. A reticulocyte that is GlyA-positive. GOC:ak - GOC:tfm + GOC:tfm PMID:1638021 @@ -53775,7 +54016,7 @@ radial glial cells acting as neural progenitors throughout life. An enucleate erythrocyte that is GlyA-positive. GOC:ak - GOC:tfm + GOC:tfm PMID:20134094 @@ -53826,7 +54067,7 @@ radial glial cells acting as neural progenitors throughout life. An enucleate erythrocyte that is Lyg-76-high. GOC:ak - GOC:tfm + GOC:tfm PMID:19805084 @@ -53897,7 +54138,7 @@ radial glial cells acting as neural progenitors throughout life. A megakaroycotye progenitor cell that is CD34-positive, CD41-positive and CD42-positive on the cell surface. GOC:ak - GOC:tfm + GOC:tfm PMID:15232614 @@ -54008,7 +54249,7 @@ radial glial cells acting as neural progenitors throughout life. A megakaryocyte progenitor cell that is Kit-positive, CD41-positive, CD9-positive, Sca-1-negative, IL7ralpha-negative, CD150-negative, and Fcgamma receptor II/III-low. GOC:ak - GOC:tfm + GOC:tfm PMID:16951553 @@ -54079,7 +54320,7 @@ radial glial cells acting as neural progenitors throughout life. A megakaryocyte progenitor cell that is CD34-positive, CD41-positive, and CD42-negative. GOC:ak - GOC:tfm + GOC:tfm PMID:15232614 @@ -54150,7 +54391,7 @@ radial glial cells acting as neural progenitors throughout life. A megakaryocyte progenitor cell that is CD34-negative, CD41-positive and CD42-positive. GOC:ak - GOC:tfm + GOC:tfm PMID:15232614 @@ -54210,7 +54451,7 @@ radial glial cells acting as neural progenitors throughout life. A megakaryocyte cell with is CD9-positive and CD41-positive. - GOC:tfm + GOC:tfm @@ -54327,7 +54568,7 @@ radial glial cells acting as neural progenitors throughout life. A cell type that can give rise to basophil and mast cells. This cell is CD34-positive, CD117-positive, CD125-positive, FceRIa-negative, and T1/ST2-negative, and expresses Gata-1, Gata-2, C/EBPa GOC:ak GOC:dsd - GOC:tfm + GOC:tfm PMCID:PMC1312421 @@ -54404,7 +54645,7 @@ radial glial cells acting as neural progenitors throughout life. A lineage-negative, Kit-positive, CD45-positive mast cell progenitor that is Fc-epsilon RIalpha-low. - GOC:tfm + GOC:tfm PMCID:PMC1312421 @@ -54472,7 +54713,7 @@ radial glial cells acting as neural progenitors throughout life. A lineage negative, Sca1-negative basophil progenitor cell that is Fc epsilon RIalpha-high. - GOC:tfm + GOC:tfm PMCID:PMC1312421 @@ -54516,7 +54757,7 @@ radial glial cells acting as neural progenitors throughout life. A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells. - GOC:tfm + GOC:tfm PMID:19022770 @@ -54560,7 +54801,7 @@ radial glial cells acting as neural progenitors throughout life. A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. - GOC:tfm + GOC:tfm PMID:19022770 https://orcid.org/0000-0001-5208-3432 @@ -54627,7 +54868,7 @@ radial glial cells acting as neural progenitors throughout life. A hematopoietic stem cell capable of rapid replenishment of myeloerythroid progenitors and limited self renewal capability. This cell is Kit-positive, Sca1-positive, CD34-positive, CD150-positive, and is Flt3-negative. - GOC:tfm + GOC:tfm PMID:15572596 PMID:19022770 @@ -54698,7 +54939,7 @@ radial glial cells acting as neural progenitors throughout life. A hematopoietic stem cell with long term self renewal capability. This cell is Kit-positive, Sca1-positive, CD150-positive, CD90-low, CD34-negative and Flt3-negative. - GOC:tfm + GOC:tfm PMID:15572596 PMID:17582345 @@ -54779,7 +55020,7 @@ radial glial cells acting as neural progenitors throughout life. A hematopoietic progenitor that has restricted self-renewal capability. Cell is Kit-positive, Ly6-positive, CD150-negative and Flt3-negative. - GOC:tfm + GOC:tfm PMID:19022770 @@ -54851,7 +55092,7 @@ radial glial cells acting as neural progenitors throughout life. A hematopoietic progenitor that has some limited self-renewal capability. Cells are lin-negative, Kit-positive, CD34-positive, and Slamf1-positive. - GOC:tfm + GOC:tfm PMID:19022770 @@ -54915,7 +55156,7 @@ radial glial cells acting as neural progenitors throughout life. Intraepithelial T cells with a memory phenotype of CD2-positive, CD5-positive, and CD44-positive. - GOC:tfm + GOC:tfm PMID:16048545 @@ -55032,7 +55273,7 @@ radial glial cells acting as neural progenitors throughout life. A CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cell located in follicles of secondary lymph nodes that expresses is BCL6-high, ICOS-high and PD1-high, and stimulates follicular B cells to undergo class-switching and antibody production. - GOC:tfm + GOC:tfm PMID:19855402 PMID:20107805 PMID:22043829 @@ -55161,7 +55402,7 @@ radial glial cells acting as neural progenitors throughout life. A CD24-high, CD4-low, CD8-low, CD44-negative, NK1.1-negative NK T cell. - GOC:tfm + GOC:tfm PMID:17589542 @@ -55232,7 +55473,7 @@ radial glial cells acting as neural progenitors throughout life. A CD24-low, CD44-negative, NK1.1-negative NK T cell. - GOC:tfm + GOC:tfm PMID:17589542 http://www.immgen.org/index_content.html @@ -55392,7 +55633,7 @@ radial glial cells acting as neural progenitors throughout life. A CD24-low, CD44-positive, DX5-high, NK1.1-negative NK T cell. - GOC:tfm + GOC:tfm PMID:17589542 http://www.immgen.org/index_content.html @@ -55467,7 +55708,7 @@ radial glial cells acting as neural progenitors throughout life. A hematopoietic multipotent progenitor cell that is CD34-positive, CD38-negative, CD45RA-negative, and CD90-negative. - GOC:tfm + GOC:tfm PMID:18371405 PMID:19022770 @@ -55553,7 +55794,7 @@ radial glial cells acting as neural progenitors throughout life. A basophil mast progenitor cell that is Beta-7 integrin-high, Kit-positive FcRgammaII/III-positive and Sca1-negative. GOC:ak - GOC:tfm + GOC:tfm @@ -55659,7 +55900,7 @@ radial glial cells acting as neural progenitors throughout life. A pro-B cell that CD45R/B220-positive, CD43-positive, HSA-low, BP-1-negative and Ly6c-negative. This cell type is also described as being lin-negative, AA4-positive, Kit-positive, IL7Ra-positive and CD45R-positive. GOC:ak - GOC:tfm + GOC:tfm PMID:12633665 PMID:17582343 http://www.immgen.org/index_content.html @@ -55786,7 +56027,7 @@ radial glial cells acting as neural progenitors throughout life. A pro-B cell that is CD22-positive, CD34-positive, CD38-positive and TdT-positive (has TdT activity). Pre-BCR is expressed on the cell surface. Cell is CD19-negative, CD20-negative, complement receptor type 2-negative and CD10-low. D-to-J recombination of the heavy chain occurs at this stage. GOC:dsd - GOC:tfm + GOC:tfm PMID:18432934 @@ -55853,7 +56094,7 @@ radial glial cells acting as neural progenitors throughout life. A precursor B cell that is CD45RA-positive, CD43-positive, CD24-positive and BP-1-negative. GOC:ak - GOC:tfm + GOC:tfm PMID:18432934 @@ -55934,7 +56175,7 @@ radial glial cells acting as neural progenitors throughout life. A pre-B cell precursor is CD19-low, CD22-positive , CD34-positive, CD38-positive. GOC:dsd - GOC:tfm + GOC:tfm PMID:18432934 @@ -56048,7 +56289,7 @@ radial glial cells acting as neural progenitors throughout life. A precursor B cell is CD45R-positive, CD43-positive, CD24-positive, and BP-positive. Intracellularly expression of surrogate light chain, Rag1 and Rag2, TdT, occurs while there is no expression of mu heavy chain. - GOC:tfm + GOC:tfm PMID:17582343 @@ -56149,7 +56390,7 @@ radial glial cells acting as neural progenitors throughout life. A pre-BCR-positive precursor B cell that is CD24-high, CD25-positive, CD43-positive, CD45R-positive and BP-positive. - GOC:tfm + GOC:tfm PMID:17582343 @@ -56210,7 +56451,7 @@ radial glial cells acting as neural progenitors throughout life. A pre-BCR positive B cell that is CD38-high. - GOC:tfm + GOC:tfm PMID:18432934 @@ -56320,7 +56561,7 @@ radial glial cells acting as neural progenitors throughout life. A pre-B cell that is pre-BCR-negative, and the kappa- and lambda- light immunoglobulin light chain-negative, CD43-low, and is BP-1-positive, CD45R-positive and CD25-positive. This cell type is also described as being AA4-positive, IgM-negative, CD19-positive, CD43-low/negative, and HSA-positive. GOC:ak GOC:dsd - GOC:tfm + GOC:tfm PMID:17582343 PMID:18432934 http://www.immgen.org/index_content.html @@ -56329,7 +56570,7 @@ radial glial cells acting as neural progenitors throughout life. Fraction D pre-B cell - GOC:tfm + GOC:tfm @@ -56389,7 +56630,7 @@ radial glial cells acting as neural progenitors throughout life. A small pre-B cell that is CD22-positive and CD38-low. - GOC:tfm + GOC:tfm PMID:18432934 @@ -56485,7 +56726,7 @@ radial glial cells acting as neural progenitors throughout life. An immature B cell that is IgM-positive, CD45R-positive, CD43-low, CD25-negative, and CD127-negative. This cell type has also been described as being AA4-positive, IgM-positive, CD19-positive, CD43-low/negative, and HSA-positive. GOC:ak GOC:dsd - GOC:tfm + GOC:tfm PMID:17582343 PMID:18432934 @@ -56566,7 +56807,7 @@ radial glial cells acting as neural progenitors throughout life. An immature B cell that is CD38-negative, CD10-low, CD21-low, and CD22-high. - GOC:tfm + GOC:tfm PMID:18432934 @@ -56667,7 +56908,7 @@ radial glial cells acting as neural progenitors throughout life. A mature B cell subset originally defined as having being CD45R-positive, IgM-positive, IgD-positive and CD43-negative. Subsequent research demonstrated being CD21-positive and CD23-negative and CD93 negative. - GOC:tfm + GOC:tfm PMID:17582343 @@ -56739,7 +56980,7 @@ radial glial cells acting as neural progenitors throughout life. A classical monocyte that is CD14-positive, CD16-negative, CD64-positive, CD163-positive. GOC:add - GOC:tfm + GOC:tfm PMID:15615263 PMID:1706877 PMID:19689341 @@ -56841,7 +57082,7 @@ radial glial cells acting as neural progenitors throughout life. A resident monocyte that is Gr-1 low, CD43-positive, and CX3CR1-positive. - GOC:tfm + GOC:tfm PMID:8890901 @@ -56886,7 +57127,7 @@ radial glial cells acting as neural progenitors throughout life. A conventional thymic dendritic cell that is CD8alpha-positive. - GOC:tfm + GOC:tfm PMID:19273629 http://www.immgen.org/index_content.html @@ -56940,7 +57181,7 @@ radial glial cells acting as neural progenitors throughout life. A melanin-containing macrophage that obtains the pigment by phagocytosis of melanosomes. - GOC:tfm + GOC:tfm PMID:20479296 PMID:2943821 @@ -57007,7 +57248,7 @@ radial glial cells acting as neural progenitors throughout life. A T-helper cell that is characterized by secreting interleukin 9 and responding to helminth infections. This cell-type can derives from Th2 cells in the presence of TGF-beta and IL-4. Th2 cytokine production is surpressed. - GOC:tfm + GOC:tfm PMID:18931678 PMID:19604299 PMID:20154671 @@ -57066,7 +57307,7 @@ radial glial cells acting as neural progenitors throughout life. A type I pneumocyte is a flattened, branched pneumocyte that covers more than 98% of the alveolar surface. This large cell has thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange. - GOC:tfm + GOC:tfm PMID:20054144 http://www.copewithcytokines.de @@ -57120,7 +57361,7 @@ radial glial cells acting as neural progenitors throughout life. A type II pneumocyte is a pneumocyte that modulates the fluid surrounding the alveolar epithelium by secreting and recycling surfactants. This cell type also contributes to tissue repair and can differentiate after injury into a type I pneumocyte. Thicker than squamous alveolar cells, have a rounded apical surface that projects above the level of surrounding epithelium. The free surface is covered by short microvilli. - GOC:tfm + GOC:tfm ISBN:0412046911 PMID:8540632 http://www.copewithcytokines.de @@ -57176,7 +57417,7 @@ radial glial cells acting as neural progenitors throughout life. A secretory cell found in pancreatic acini that secretes digestive enzymes and mucins. This cell is a typical zymogenic cell, have a basal nucleus and basophilic cytoplasm consisting of regular arrays of granular endoplasmic reticulum with mitochondria and dense secretory granules. - GOC:tfm + GOC:tfm ISBN:0517223651 PMID:20395539 http://www.copewithcytokines.de/cope.cgi?key=pancreatic%20acinar%20cells @@ -57203,7 +57444,7 @@ radial glial cells acting as neural progenitors throughout life. A neuroendocrine cell found in the epithelium of the lungs and respiratory tract. This cell type is rounded or elliptical in shape, situated mainly in the basal part of the epithelium; regulates bronchial secretion, smooth muscle contraction, lobular growth, ciliary activity and chemoreception. Cell has an electron-lucent cytoplasm, contains numerous dense-cored vesicles with a clear halo between the core and the limiting membrane. - GOC:tfm + GOC:tfm ISBN:0412046911 ISBN:0517223651 @@ -57237,7 +57478,7 @@ radial glial cells acting as neural progenitors throughout life. An enteroendocrine cell that produces glucagon. - GOC:tfm + GOC:tfm ISBN:0412046911 @@ -57263,7 +57504,7 @@ radial glial cells acting as neural progenitors throughout life. Specialized cardiac myocyte that is subendocardially interspersed with the regular cardiac muscle cell. They are uninucleate cylindrical cells, associated end-to-end in long rows, continue from the node to the atrioventricular bundle; relatively short compared to ordinary myocytes but are nearly twice their diameter. FMA:0412046911 - GOC:tfm + GOC:tfm PMID:19939742 @@ -57287,7 +57528,7 @@ radial glial cells acting as neural progenitors throughout life. Mostly cylindrical, resemble Type 1 in their contents and the presence of a kinocilium and stereocilium apically; much greater variation in size, some almost span the entire thickness of the sensory epithelium, while others are smaller than Type 1; receive multiple efferent nerve boutons around their bases as well as afferent endings, which are small expansions rather than chalices. - GOC:tfm + GOC:tfm ISBN:0517223651 @@ -57311,7 +57552,7 @@ radial glial cells acting as neural progenitors throughout life. Bottle-shaped with narrow neck; broad, rounded basal portion where nucleus is located; stereocilia and a single kinocilium is present apically; receive nerve bouton at their base from an afferent cup-shaped (chalice or calyx) nerve ending. - GOC:tfm + GOC:tfm ISBN:0517223651 @@ -57361,7 +57602,7 @@ radial glial cells acting as neural progenitors throughout life. Columnar cell which populate the epithelium of large intestine and absorb water. This cell is the most numerous of the epithelial cell types in the large intestine; bear apical microvilli, contain secretory granules in their apical cytoplasm; secretion appears to be largely mucins, but is also rich in antibodies of the IgA type. - GOC:tfm + GOC:tfm ISBN:0517223651 @@ -57388,7 +57629,7 @@ radial glial cells acting as neural progenitors throughout life. A specialized cardiac myocyte in the sinoatrial and atrioventricular nodes. The cell is slender and fusiform confined to the nodal center, circumferentially arranged around the nodal artery. FMA:67101 - GOC:tfm + GOC:tfm @@ -57415,7 +57656,7 @@ radial glial cells acting as neural progenitors throughout life. Specialized cardiac myocyte which is in the internodal tract and atrioventricular node. The cell is more slender than ordinary atrial myocytes and has more myofibrils than nodal myocytes. FMA:67142 - GOC:tfm + GOC:tfm @@ -57437,7 +57678,7 @@ radial glial cells acting as neural progenitors throughout life. The myoendocrine cellis a specialized myocyte localized mainly in the right and left atrial appendages, and also scattered within other areas of the atria and along the conductive system in the ventricular septum. The most conspicuous feature distinguishing myoendocrine cells from other atrial myoctyes is the presence of membane-bounded secretory granules (these granules contain precursor of cardiodilatins or atrial natriuretic polypeptides). FMA:67111 - GOC:tfm + GOC:tfm @@ -57469,7 +57710,7 @@ radial glial cells acting as neural progenitors throughout life. Infrequent type of columnar epithelial cell. This cell is characterized by the presence of a tuft of blunt, squat microvilli (approximately 120-140/cell) on the cell surface. The microvilli contain filaments that stretch into the underlying cytoplasm. They have a distinctive pear shape with a wide base and a narrow microvillous apex. Function not known. - GOC:tfm + GOC:tfm ISBN:0517223651 PMID:15817800 @@ -57499,7 +57740,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell derived from endoderm. FMA:69075 - GOC:tfm + GOC:tfm @@ -57538,7 +57779,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell derived from ectoderm. FMA:69074 - GOC:tfm + GOC:tfm @@ -57578,7 +57819,7 @@ radial glial cells acting as neural progenitors throughout life. Epithelial cell derived from mesoderm or mesenchyme. FMA:69076 - GOC:tfm + GOC:tfm @@ -57627,7 +57868,7 @@ radial glial cells acting as neural progenitors throughout life. Epithelial cell found in the ducts of the pancreas. This cell type contributes to the high luminal pH. FMA:63099 - GOC:tfm + GOC:tfm PMID:14740223 @@ -57677,7 +57918,7 @@ radial glial cells acting as neural progenitors throughout life. A cubodial epithelial cell that is continuous with the lining of intercalated ducts that drain the acinus. This cell type secretes a high pH solution to aid in activation of zymogens, and can differentiate into endocrine and exocrine pancreatic cell types. - GOC:tfm + GOC:tfm PMID:12142741 PMID:20018761 PMID:8185160 @@ -57702,7 +57943,7 @@ radial glial cells acting as neural progenitors throughout life. This cell resembles a glia cell, express the glial marker S100 and act as a supporting cell to type I cell. This cell is located in a small cluster of type I and type II cells near the fork of the carotid artery. - GOC:tfm + GOC:tfm PMID:7938227 http://en.wikipedia.org/wiki/Carotid_body @@ -57749,7 +57990,7 @@ radial glial cells acting as neural progenitors throughout life. A chromaffin cell of the adrenal medulla that produces epinephrine. - GOC:tfm + GOC:tfm @@ -57792,7 +58033,7 @@ radial glial cells acting as neural progenitors throughout life. A chromaffin cell of the adrenal medulla that produces norepinephrine. - GOC:tfm + GOC:tfm ISBN:068340007X @@ -57815,7 +58056,7 @@ radial glial cells acting as neural progenitors throughout life. A Boettcher cell is a polyhedral cells on the basilar membrane of the cochlea, and is located beneath Claudius cells. A Boettcher cell is considered a supporting cell for the organ of Corti, and is present only in the lower turn of the cochlea. These cells interweave with each other, and project microvilli into the intercellular space. Because of their structural specialization, a Boettcher cell is believed to play a significant role in the function of the cochlea. They demonstrate high levels of calmodulin, and may be involved in mediating Ca(2+) regulation and ion transport. - GOC:tfm + GOC:tfm http://en.wikipedia.org/wiki/Boettcher_cell @@ -57839,7 +58080,7 @@ radial glial cells acting as neural progenitors throughout life. Specialized elongated ventricular ependymal cell that has processes that extend to the outer, or pial, surface of the CNS. Resemble spongioblasts seen in developing brain. Found in the adult brain in the third ventricle, cerebral aqueduct, spinal canal and floor of the fourth ventricle. - GOC:tfm + GOC:tfm http://neurolex.org/wiki/Category:Tanycyte @@ -57861,7 +58102,7 @@ radial glial cells acting as neural progenitors throughout life. A cardiac myocyte that is an excitable cells in the myocardium, specifically in the conducting system of heart. FMA:67968 - GOC:tfm + GOC:tfm @@ -57905,7 +58146,7 @@ radial glial cells acting as neural progenitors throughout life. A leukocyte that lacks granules. - GOC:tfm + GOC:tfm @@ -57952,7 +58193,7 @@ radial glial cells acting as neural progenitors throughout life. This is a cell found in the gastrointestinal tract of mammals and serves as a pacemaker that triggers gut contraction. ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which gastrointestinal stromal tumors (GISTs) arise. - GOC:tfm + GOC:tfm PMID:16460275 PMID:19520112 @@ -58156,7 +58397,7 @@ radial glial cells acting as neural progenitors throughout life. A group 2 innate lymphoid cell in the mouse capable of secreting IL-13 in response to a helminth infection. This cell is lineage-negative, ICOS-positive, IL1RL1-positive, IL7Ralpha-positive, and IL17Br-positive. GOC:add - GOC:tfm + GOC:tfm PMID:20200518 @@ -58180,7 +58421,7 @@ radial glial cells acting as neural progenitors throughout life. One of two small cells formed by the first and second meiotic division of oocytes. - GOC:tfm + GOC:tfm ISBN:068340007X http://en.wikipedia.org/wiki/Polar_body @@ -58207,7 +58448,7 @@ radial glial cells acting as neural progenitors throughout life. A small cell formed by the first meiotic division of oocytes. - GOC:tfm + GOC:tfm ISBN:068340007X @@ -58265,7 +58506,7 @@ radial glial cells acting as neural progenitors throughout life. A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells. - GOC:tfm + GOC:tfm ISBN:0618947256 @@ -58291,7 +58532,7 @@ radial glial cells acting as neural progenitors throughout life. A small cell formed by the second meiotic division of oocytes. In mammals, the second polar body may fail to form unless the ovum has been penetrated by a sperm cell. - GOC:tfm + GOC:tfm ISBN:068340007X @@ -58324,7 +58565,7 @@ radial glial cells acting as neural progenitors throughout life. A cell that makes up the loose connective tissue of the ovary. - GOC:tfm + GOC:tfm @@ -58346,7 +58587,7 @@ radial glial cells acting as neural progenitors throughout life. A cell in the hilum of the ovary that produces androgens. - GOC:tfm + GOC:tfm ISBN:068340007X @@ -58384,7 +58625,7 @@ radial glial cells acting as neural progenitors throughout life. A specialised myocyte that lies between the sinoatrial node and the atrioventricular node and is involved in the conduction of electrical signals. - GOC:tfm + GOC:tfm ISBN:0781729300 @@ -58426,7 +58667,7 @@ radial glial cells acting as neural progenitors throughout life. A cell of the adrenal cortex. Cell types include those that synthesize and secrete chemical derivatives (steroids) of cholesterol. - GOC:tfm + GOC:tfm @@ -58448,7 +58689,7 @@ radial glial cells acting as neural progenitors throughout life. A cardiac myocyte that is connected to other cardiac myocytes by transverse intercalated discs (GO:0014704) at a regular interval. - GOC:tfm + GOC:tfm @@ -58494,7 +58735,7 @@ radial glial cells acting as neural progenitors throughout life. A small, polyhedral, cell found in rounded groups or curved columns with deeply staining nuclei, scanty basophilic cytoplasm and a few lipid droplets. This cell in the zona glomerulosa produces mineralocorticoids. - GOC:tfm + GOC:tfm ISBN:0517223651 @@ -58515,7 +58756,7 @@ radial glial cells acting as neural progenitors throughout life. A regular cardiac myocyte of the interventricular region of the heart. - GOC:tfm + GOC:tfm @@ -58564,7 +58805,7 @@ radial glial cells acting as neural progenitors throughout life. A CD38-positive naive B cell is a mature B cell that has the phenotype CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery. GOC:dsd GOC:rhs - GOC:tfm + GOC:tfm PMID:20123131 @@ -58614,7 +58855,7 @@ radial glial cells acting as neural progenitors throughout life. A CD38-negative naive B cell is a mature B cell that has the phenotype CD38-negative, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery. GOC:dsd GOC:rhs - GOC:tfm + GOC:tfm PMID:20123131 @@ -58672,7 +58913,7 @@ radial glial cells acting as neural progenitors throughout life. An IgG-positive double negative memory B cell is a double negative memory B cell with the phenotype IgG-positive, IgD-negative, and CD27-negative. GOC:dsd GOC:rhs - GOC:tfm + GOC:tfm PMID:20123131 @@ -58730,7 +58971,7 @@ radial glial cells acting as neural progenitors throughout life. An IgG-negative double negative memory B cell is a double negative memory B cell with the phenotype IgG-negative, IgD-negative, and CD27-negative. GOC:dsd GOC:rhs - GOC:tfm + GOC:tfm PMID:20123131 @@ -58780,7 +59021,7 @@ radial glial cells acting as neural progenitors throughout life. A CD38-positive IgG memory B cell is a class switched memory B cell that expresses IgG on the cell surface with the phenotype CD38-positive and IgG-positive. GOC:dsd GOC:rhs - GOC:tfm + GOC:tfm PMID:20123131 @@ -58823,7 +59064,7 @@ radial glial cells acting as neural progenitors throughout life. An IgD-positive CD38-positive IgG memory B cell is a CD38-positive IgG-positive class switched memory B cell that has class switched and expresses IgD on the cell surface with the phenotype IgD-positive, CD38-positive, and IgG-positive. GOC:dsd GOC:rhs - GOC:tfm + GOC:tfm PMID:20123131 @@ -58861,7 +59102,7 @@ radial glial cells acting as neural progenitors throughout life. An IgD-negative CD38-positive IgG memory B cell is a CD38-positive IgG-positive that has class switched and lacks expression of IgD on the cell surface with the phenotype IgD-negative, CD38-positive, and IgG-positive. GOC:dsd GOC:rhs - GOC:tfm + GOC:tfm PMID:20123131 @@ -58909,7 +59150,7 @@ radial glial cells acting as neural progenitors throughout life. A CD38-negative IgG memory B cell is a IgG-positive class switched memory B cell that has class switched and expresses IgG on the cell surface with the phenotype CD38-negative, IgD-negative, and IgG-positive. GOC:dsd GOC:rhs - GOC:tfm + GOC:tfm PMID:20123131 @@ -58963,7 +59204,7 @@ radial glial cells acting as neural progenitors throughout life. A B220-positive CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-positive, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery. GOC:dsd GOC:rhs - GOC:tfm + GOC:tfm PMID:20123131 @@ -59000,7 +59241,7 @@ radial glial cells acting as neural progenitors throughout life. A B220-low CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-low, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery. GOC:dsd GOC:rhs - GOC:tfm + GOC:tfm PMID:20123131 @@ -59050,7 +59291,7 @@ radial glial cells acting as neural progenitors throughout life. An CD38-negative unswitched memory B cell is an unswitched memory B cell that has the phenotype CD38-negative, IgD-positive, CD138-negative, and IgG-negative. GOC:dsd GOC:rhs - GOC:tfm + GOC:tfm PMID:20123131 @@ -59093,7 +59334,7 @@ radial glial cells acting as neural progenitors throughout life. A B220-positive CD38-negative unswitched memory B cell is a CD38-negative unswitched memory B cell that has the phenotype B220-positive, CD38-negative, IgD-positive, CD138-negative, and IgG-negative. GOC:dsd GOC:rhs - GOC:tfm + GOC:tfm PMID:20123131 @@ -59130,7 +59371,7 @@ radial glial cells acting as neural progenitors throughout life. A B220-low CD38-negative unswitched memory B cell is a CD38-negative unswitched memory B cell that has the phenotype B220-low, CD38-negative, IgD-positive, CD138-negative, and IgG-negative. GOC:dsd GOC:rhs - GOC:tfm + GOC:tfm PMID:20123131 @@ -59180,7 +59421,7 @@ radial glial cells acting as neural progenitors throughout life. A CD38-positive unswitched memory B cell is an unswitched memory B cell that has the phenotype CD38-positive, IgD-positive, CD138-negative, and IgG-negative. GOC:dsd GOC:rhs - GOC:tfm + GOC:tfm PMID:20123131 @@ -59223,7 +59464,7 @@ radial glial cells acting as neural progenitors throughout life. A B220-positive CD38-positive unswitched memory B cell is a CD38-positive unswitched memory B cell that has the phenotype B220-positive, CD38-positive, IgD-positive, CD138-negative, and IgG-negative. GOC:dsd GOC:rhs - GOC:tfm + GOC:tfm PMID:20123131 @@ -59260,7 +59501,7 @@ radial glial cells acting as neural progenitors throughout life. A B220-low CD38-positive unswitched memory B cell is a CD38-positive unswitched memory B cell that has the phenotype B220-low, CD38-positive, IgD-positive, CD138-negative, and IgG-negative. GOC:dsd GOC:rhs - GOC:tfm + GOC:tfm PMID:20123131 @@ -59310,7 +59551,7 @@ radial glial cells acting as neural progenitors throughout life. A class switched memory B cell that lacks IgG on the cell surface. GOC:dsd GOC:rhs - GOC:tfm + GOC:tfm PMID:20123131 @@ -59353,7 +59594,7 @@ radial glial cells acting as neural progenitors throughout life. A CD38-negative IgG-negative memory B cell is a IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-negative and IgG-negative. GOC:dsd GOC:rhs - GOC:tfm + GOC:tfm PMID:20123131 @@ -59396,7 +59637,7 @@ radial glial cells acting as neural progenitors throughout life. A CD38-positive IgG-negative memory B cell is an IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-positive and IgG-negative. GOC:dsd GOC:rhs - GOC:tfm + GOC:tfm PMID:20123131 @@ -59439,7 +59680,7 @@ radial glial cells acting as neural progenitors throughout life. An CD24-positive CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-positive, CD38-negative, and IgG-negative. GOC:dsd GOC:rhs - GOC:tfm + GOC:tfm PMID:20123131 @@ -59482,7 +59723,7 @@ radial glial cells acting as neural progenitors throughout life. A CD24-negative CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-negative, CD38-negative, and IgG-negative. GOC:dsd GOC:rhs - GOC:tfm + GOC:tfm PMID:20123131 @@ -59525,7 +59766,7 @@ radial glial cells acting as neural progenitors throughout life. A B220-positive CD38-positive IgG-negative memory B cell is a CD38-positive IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype B220-positive, CD38-positive, and IgG-negative. GOC:dsd GOC:rhs - GOC:tfm + GOC:tfm PMID:20123131 @@ -59562,7 +59803,7 @@ radial glial cells acting as neural progenitors throughout life. A B220-low CD38-positive IgG-negative memory B cell is a CD38-positive IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype B220-low, CD38-positive, and IgG-positive. GOC:dsd GOC:rhs - GOC:tfm + GOC:tfm PMID:20123131 @@ -59634,7 +59875,7 @@ radial glial cells acting as neural progenitors throughout life. A circulating gamma-delta T cell that is CD27-positive and capable of producing IFN-gamma. GOC:dsd - GOC:tfm + GOC:tfm PMID:19270712 @@ -59715,7 +59956,7 @@ radial glial cells acting as neural progenitors throughout life. A circulating gamma-delta T cell that expresses RORgamma(t), is CD27-negative and is capable of IL-17 secretion. GOC:dsd - GOC:tfm + GOC:tfm PMID:19270712 @@ -59829,7 +60070,7 @@ radial glial cells acting as neural progenitors throughout life. A CD25-positive, CD27-positive immature gamma-delta T cell found in the thymus that has an immature phenotype (i.e. CD24-high, CD25-high, CD62L-high, CD44-high, CD2-low, CD5-low). - GOC:tfm + GOC:tfm PMID:19270712 @@ -59872,7 +60113,7 @@ radial glial cells acting as neural progenitors throughout life. A T cell with a receptor of limited diversity that is capable of immediate effector functions upon stimulation. - GOC:tfm + GOC:tfm PMID:20581831 @@ -59954,7 +60195,7 @@ radial glial cells acting as neural progenitors throughout life. A CD8-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-positive, CCR5-high, CD45RA-negative, and capable of producing IL-17 and some IFNg. GOC:add GOC:dsd - GOC:tfm + GOC:tfm PMID:19201830 PMID:22343568 @@ -59986,7 +60227,7 @@ radial glial cells acting as neural progenitors throughout life. Regular cardiac myocyte of a cardiac atrium. - GOC:tfm + GOC:tfm @@ -60012,7 +60253,7 @@ radial glial cells acting as neural progenitors throughout life. A cardiac myocyte of the interatrial region of the heart. - GOC:tfm + GOC:tfm @@ -60036,7 +60277,7 @@ radial glial cells acting as neural progenitors throughout life. Regular cardiac myocyte of a cardiac ventricle. - GOC:tfm + GOC:tfm @@ -60080,7 +60321,7 @@ radial glial cells acting as neural progenitors throughout life. A stomal cell of the ovary - GOC:tfm + GOC:tfm @@ -60106,7 +60347,7 @@ radial glial cells acting as neural progenitors throughout life. A stromal cell of the ovarian cortex. - GOC:tfm + GOC:tfm @@ -60149,7 +60390,7 @@ radial glial cells acting as neural progenitors throughout life. A stromal cell of the ovarian medulla. - GOC:tfm + GOC:tfm @@ -60198,7 +60439,7 @@ radial glial cells acting as neural progenitors throughout life. A cell in the zona fasciculata that produce glucocorticoids, e.g cortisol. - GOC:tfm + GOC:tfm ISBN:0517223651 @@ -60220,7 +60461,7 @@ radial glial cells acting as neural progenitors throughout life. A cell in the zona reticularis that produce sex hormones. - GOC:tfm + GOC:tfm ISBN:0517223651 @@ -60278,7 +60519,7 @@ radial glial cells acting as neural progenitors throughout life. A endothelial cell of a lymphatic vessel. The border of the oak leaf-shaped endothelial cell of initial lymphatics are joined by specialized buttons. The discontinuous feature of buttons distinguishes them from zippers in collecting lymphatics, but both types of junctions are composed of proteins typical of adherens junctions and tight junctions found in the endothelium of blood vessels. Buttons seal the sides of flaps of the oak leaf-shaped endothelial cell, leaving open the tips of flaps as routes for fluid entry without disassembly and reformation of intercellular junctions. - GOC:tfm + GOC:tfm PMID:17846148 @@ -60305,7 +60546,7 @@ radial glial cells acting as neural progenitors throughout life. An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels. GOC:dsd - GOC:tfm + GOC:tfm PMID:12768659 @@ -60354,7 +60595,7 @@ radial glial cells acting as neural progenitors throughout life. A sebum secreting cell of the skin that secretes sebum into the hair follicles. - GOC:tfm + GOC:tfm @@ -60375,7 +60616,7 @@ radial glial cells acting as neural progenitors throughout life. A parathyroid chief cell that is actively secreting hormone. Have large Golgi complexes with numerous vesicles and small membrane-bound granules; secretory granules are rare, cytoplasmic glycogen sparse, much of the cytoplasm being occupied by flat sacs of granular endoplasmic reticulum in parallel arrays; in normal humans, inactive chief cells outnumber active chief cells in a ratio of 3-5:1 FMA:0517223651 - GOC:tfm + GOC:tfm @@ -60424,7 +60665,7 @@ radial glial cells acting as neural progenitors throughout life. A chief cell that is smaller than light chief cells and has a smaller and darker nucleus and a finely granular cytoplasm with many granules. - GOC:tfm + GOC:tfm ISBN:0721662544 @@ -60470,7 +60711,7 @@ radial glial cells acting as neural progenitors throughout life. An endothelial cell found in capillaries. - GOC:tfm + GOC:tfm @@ -60497,7 +60738,7 @@ radial glial cells acting as neural progenitors throughout life. A ciliated columnar cell found in the trachea and bronchus. Vary from low to tall columnar; possesses up to 300 cilia at its surface, interspersed with long irregular microvilli with the cilia varying in length from about 6um in the trachea to about 4um in the terminal bronchioles; driving force of the ciliary current in the bronchial tree. - GOC:tfm + GOC:tfm ISBN:0517223651 @@ -60527,7 +60768,7 @@ radial glial cells acting as neural progenitors throughout life. A sweat producing cell of eccrine sweat glands. Pyramidal in shape, with its base resting on the basal lamina or myoepitheliocytes, and its microvillus-covered apical plasma membrane line up the intercellular canaliculi. Cell is not stained by hematoxylin or eosin. - GOC:tfm + GOC:tfm ISBN:0517223651 @@ -60549,7 +60790,7 @@ radial glial cells acting as neural progenitors throughout life. A chief cell of parathyroid glands that does not stain with hematoxylin or eosin. This cell is larger, has a larger nucleus and fewer secretory granules than dark chief cells. - GOC:tfm + GOC:tfm ISBN:0618947256 @@ -60590,7 +60831,7 @@ radial glial cells acting as neural progenitors throughout life. A cell found within the dental pulp. - GOC:tfm + GOC:tfm PMID:11087820 @@ -60635,7 +60876,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell of the uterus. - GOC:tfm + GOC:tfm @@ -60719,7 +60960,7 @@ radial glial cells acting as neural progenitors throughout life. A columnar cell of the cervix uteri. - GOC:tfm + GOC:tfm ISBN:0721662544 @@ -60754,7 +60995,7 @@ radial glial cells acting as neural progenitors throughout life. The dead keratin-filled squamous cell of the stratum corneum. This cell type lacks a nucleus. - GOC:tfm + GOC:tfm ISBN:068340007X @@ -60776,7 +61017,7 @@ radial glial cells acting as neural progenitors throughout life. A promyelocyte with a nucleus that is indented and contains more marginated heterochromatin compared to its precursor cell (myeloblast); cytoplasm is deeply basophilic and contains numerous mitochondria and meandering cysternae of endoplasmic reticulum; largest of the granulocyte lineages. FMA:0412046911 - GOC:tfm + GOC:tfm @@ -60797,7 +61038,7 @@ radial glial cells acting as neural progenitors throughout life. A crenated erythrocyte with 30+ crenations, bumps or spurs that are the result of damage due to age or disease. - GOC:tfm + GOC:tfm @@ -60825,7 +61066,7 @@ radial glial cells acting as neural progenitors throughout life. A cell type that makes up the highly vascular membrane lining the marrow cavity of long bones. FMA:0618947256 - GOC:tfm + GOC:tfm @@ -60845,7 +61086,7 @@ radial glial cells acting as neural progenitors throughout life. Epithelial cell found on the external side of the tympanic membrane - GOC:tfm + GOC:tfm PMID:5686391 @@ -60866,7 +61107,7 @@ radial glial cells acting as neural progenitors throughout life. Epithelial cells derived from general body ectoderm and ectoderm placodes. - GOC:tfm + GOC:tfm @@ -60931,7 +61172,7 @@ radial glial cells acting as neural progenitors throughout life. An extremely flattened cell type found on the inner side of the tympanic membrane. The surface of this cell type carries sparse pleomorphic microvilli that are more common near the junctional zones. FMA:5686391 - GOC:tfm + GOC:tfm @@ -60952,7 +61193,7 @@ radial glial cells acting as neural progenitors throughout life. A rod-shpaed cell that forms a single row adjacent to and supporting the inner hair cells. - GOC:tfm + GOC:tfm http://www.theodora.com/anatomy/the_internal_ear_or_labyrinth.html @@ -60973,7 +61214,7 @@ radial glial cells acting as neural progenitors throughout life. A rod-shaped cell found in 3 or 4 rows that lie adjacent to and support the outer hair cells. - GOC:tfm + GOC:tfm http://www.theodora.com/anatomy/the_internal_ear_or_labyrinth.html @@ -60994,7 +61235,7 @@ radial glial cells acting as neural progenitors throughout life. A supporting cell that is attached to the basement membrane and forms rows that support the hair cells. - GOC:tfm + GOC:tfm ISBN:0618947256 @@ -61030,7 +61271,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell that remains from the disintegration of the epithelial root sheath involved in the development of teeth. - GOC:tfm + GOC:tfm ISBN:0517223651 ISBN:0815129521 @@ -61070,7 +61311,7 @@ radial glial cells acting as neural progenitors throughout life. A specialized cell involved in sensory perception of smell. - GOC:tfm + GOC:tfm PMID:7143026 @@ -61092,7 +61333,7 @@ radial glial cells acting as neural progenitors throughout life. A border cell is a slender columnar cell on the medial portion of the basilar membrane. FMA:0412046911 - GOC:tfm + GOC:tfm @@ -61138,7 +61379,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell located on the basal lamina of the olfactory epithelium. - GOC:tfm + GOC:tfm PMID:7143026 @@ -61177,7 +61418,7 @@ radial glial cells acting as neural progenitors throughout life. A keratinized cell located in the hard palate or gingiva. - GOC:tfm + GOC:tfm PMID:12014572 @@ -61199,7 +61440,7 @@ radial glial cells acting as neural progenitors throughout life. A rounded or elliptical epithelial cell, with pale-staining open face nucleus and pale cytoplasm rich in free ribosomes and clusters of centrioles; form a distinct basal zone spaced slightly from the basal surface of the epithelium. - GOC:tfm + GOC:tfm PMID:17468753 @@ -61227,7 +61468,7 @@ radial glial cells acting as neural progenitors throughout life. A long, spindle-shaped supporting cells arranged in parallel rows that secretes components of the tectorial membrane and potassium ions into the endolymph. - GOC:tfm + GOC:tfm MP:0004482 PMID:2111803 @@ -61280,7 +61521,7 @@ radial glial cells acting as neural progenitors throughout life. A cell that is a specialized type of pericyte providing structural support for the capillary loops of kidney. A flat, elongated cell with extensive fine cytoplasmic processes found outside the kidney glomerulus near the macula densa and bound laterally by afferent and efferent arterioles. Being phagocytic, this cell participates in the continuous turnover of the basal lamina by removing its outer portion containing residues of filtration, while the lamina is renewed on its inner surface by the endothelial cells. - GOC:tfm + GOC:tfm ISBN:0412046911 http:/www.copewithcytokines.de/cope.cgi?key=Lacis%20cells @@ -61303,7 +61544,7 @@ radial glial cells acting as neural progenitors throughout life. A cell within the follicle of an ovary. - GOC:tfm + GOC:tfm @@ -61323,7 +61564,7 @@ radial glial cells acting as neural progenitors throughout life. A cell within the primary follicle of the ovary. - GOC:tfm + GOC:tfm @@ -61343,7 +61584,7 @@ radial glial cells acting as neural progenitors throughout life. A cell of a secondary follicile within the ovary. - GOC:tfm + GOC:tfm @@ -61390,7 +61631,7 @@ radial glial cells acting as neural progenitors throughout life. A supporting cell of the anterior pituitary gland involved in trophic and catabolic processes; expresses a broad spectrum of cytokeratins indicative of their epithelial nature. - GOC:tfm + GOC:tfm @@ -61434,7 +61675,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell found in the lining of the stomach. - GOC:tfm + GOC:tfm @@ -61454,7 +61695,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell within one of the pits in the embryonic gastric mucosa from which the gastric glands develop . - GOC:tfm + GOC:tfm http://www.merriam-webster.com/medical/foveolar @@ -61493,7 +61734,7 @@ radial glial cells acting as neural progenitors throughout life. A mucous cell in the epithelium of the stomach. - GOC:tfm + GOC:tfm @@ -61545,7 +61786,7 @@ radial glial cells acting as neural progenitors throughout life. A neck cell that secretes mucus within the stomach. Its products are distinct histochemically from those of the surface mucous cells of stomach. - GOC:tfm + GOC:tfm ISBN:0517223651 @@ -61567,7 +61808,7 @@ radial glial cells acting as neural progenitors throughout life. A simple columnar cell that populates the entire luminal surface including the gastric pits. This cell types secrete mucus to form a thick protective, lubricant layer over the gastric wall. - GOC:tfm + GOC:tfm ISBN:0517223651 @@ -61614,7 +61855,7 @@ radial glial cells acting as neural progenitors throughout life. A stomach epithelial cell that is olumnar in form with a few short apical microvilli; relatively undifferentiated mitotic cell from which other types of gland are derived; few in number, situated in the isthmus region of the gland and base of the gastric pit. - GOC:tfm + GOC:tfm ISBN:0517223651 @@ -61636,7 +61877,7 @@ radial glial cells acting as neural progenitors throughout life. A flat or angular epithelial cell with condensed nuclei and darkly staining cytoplasm containing numerous intermediate filaments inserted into desmosomes contacting surrounding supporting cells; lie in contact with the basal lamina of olfactory epithelium. - GOC:tfm + GOC:tfm PMID:0517223651 PMID:11891623 @@ -61679,7 +61920,7 @@ radial glial cells acting as neural progenitors throughout life. A basally situated, mitotically active, columnar-shaped keratinocyte attached to the basement membrane. - GOC:tfm + GOC:tfm ISBN:0517223651 @@ -61720,7 +61961,7 @@ radial glial cells acting as neural progenitors throughout life. An endothelial cell found in the glomerulus of the kidney. This cell is flattened, highly fenestrated, and plays a vital role in the formation of glomerular ultrafiltrate. - GOC:tfm + GOC:tfm PMID:15840009 @@ -61761,7 +62002,7 @@ radial glial cells acting as neural progenitors throughout life. A flat keratinocyte immediately below the cornified layer. - GOC:tfm + GOC:tfm ISBN:0517223651 @@ -61805,7 +62046,7 @@ radial glial cells acting as neural progenitors throughout life. A cell involved in the formation of a granulocyte. - GOC:tfm + GOC:tfm @@ -61832,7 +62073,7 @@ radial glial cells acting as neural progenitors throughout life. A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a myelocyte and a band form cell. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare. - GOC:tfm + GOC:tfm ISBN:0721601464 http://en.wikipedia.org/wiki/Metamyelocyte @@ -61862,7 +62103,7 @@ radial glial cells acting as neural progenitors throughout life. A cell type that is the first of the maturation stages of the granulocytic leukocytes normally found in the bone marrow. Granules are seen in the cytoplasm. The nuclear material of the myelocyte is denser than that of the myeloblast but lacks a definable membrane. The cell is flat and contains increasing numbers of granules as maturation progresses. - GOC:tfm + GOC:tfm ISBN:0323052908 http://en.wikipedia.org/wiki/Myelocyte @@ -61907,7 +62148,7 @@ radial glial cells acting as neural progenitors throughout life. A cell involved in the formation of a monocyte (monopoiesis). - GOC:tfm + GOC:tfm @@ -61950,7 +62191,7 @@ radial glial cells acting as neural progenitors throughout life. A stem cell that can give rise to the cells of the liver. - GOC:tfm + GOC:tfm @@ -61992,7 +62233,7 @@ radial glial cells acting as neural progenitors throughout life. A parathyroid chief cell that is not actively secreting hormone. Contains small Golgi complexes with only a few grouped vesicles and membrane-bound secretory granules; glycogen and many lipofuscin granules abound but sacs of granular endoplasmic reticulum are rare and dispersed. In normal humans, inactive chief cells out number active chief cells in a ratio of 3-5:1. - GOC:tfm + GOC:tfm ISBN:0517223651 @@ -62014,7 +62255,7 @@ radial glial cells acting as neural progenitors throughout life. A large epithelial cell with an extremely acidophilic and granular cytoplasm, containing vast numbers of mitochondria; such cells may undergo neoplastic transformation. From the Greek word onkos meaning swelling, this cell type is found in parathyroid, salivary and thyroid glands. - GOC:tfm + GOC:tfm ISBN:0721662544 PMID:20013317 @@ -62071,7 +62312,7 @@ radial glial cells acting as neural progenitors throughout life. An oncocyte located in the thyroid. - GOC:tfm + GOC:tfm PMID:20013317 @@ -62091,7 +62332,7 @@ radial glial cells acting as neural progenitors throughout life. A renal intercalated cell that secretes base and reabsorbs acid in the coritcal collecting duct to mantain acid/base balance. - GOC:tfm + GOC:tfm PMID:11781354 @@ -62130,7 +62371,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell of the tracheobronchial tree. - GOC:tfm + GOC:tfm @@ -62167,7 +62408,7 @@ radial glial cells acting as neural progenitors throughout life. Brush cell found in the epithelial layer of the colon. - GOC:tfm + GOC:tfm @@ -62209,7 +62450,7 @@ radial glial cells acting as neural progenitors throughout life. A cell type found in the gastrointestinal and respiratory tracts that is characterized by the presence of a tuft of blunt, squat microvilli (120-140 per cell). Function of this cell type is not known. - GOC:tfm + GOC:tfm ISBN:0517223651 PMID:15817800 @@ -62250,7 +62491,7 @@ radial glial cells acting as neural progenitors throughout life. A brush cell found in the epithelium of lobular bronchiole. - GOC:tfm + GOC:tfm @@ -62288,7 +62529,7 @@ radial glial cells acting as neural progenitors throughout life. A brush cell of the epithelium in the terminal bronchiole. - GOC:tfm + GOC:tfm @@ -62339,7 +62580,7 @@ radial glial cells acting as neural progenitors throughout life. Brush cell of the epithelium in the trachea. - GOC:tfm + GOC:tfm @@ -62384,7 +62625,7 @@ radial glial cells acting as neural progenitors throughout life. A brush cell found in the epithelium of bronchus. - GOC:tfm + GOC:tfm @@ -62405,7 +62646,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell present in the trachea and bronchi; columnar in shape; generally lack cilia; immature forms of ciliated or secretory cells which have been formed from stem cells. - GOC:tfm + GOC:tfm ISBN:0517223651 @@ -62428,7 +62669,7 @@ radial glial cells acting as neural progenitors throughout life. A slow muscle cell that contains high levels of myoglobin and oxygen storing proteins giving the cell a red appearance. - GOC:tfm + GOC:tfm ISBN:0517223651 @@ -62461,7 +62702,7 @@ radial glial cells acting as neural progenitors throughout life. A slow muscle cell that has large amounts of myoglobin, stores energy as triglycerides, generates ATP by the oxidative method and is resistant to fatigue. - GOC:tfm + GOC:tfm ISBN:0517223651 @@ -62504,7 +62745,7 @@ radial glial cells acting as neural progenitors throughout life. A fast muscle fiber cell that stores energy in the form of glycogen and creatine phosphate. - GOC:tfm + GOC:tfm @@ -62524,7 +62765,7 @@ radial glial cells acting as neural progenitors throughout life. A muscle cell with low content of myoglobin and other oxygen storing proteins. This muscle cell has a white appearance. - GOC:tfm + GOC:tfm ISBN:0517223651 @@ -62552,7 +62793,7 @@ radial glial cells acting as neural progenitors throughout life. A type II muscle cell that contains large amounts of myoglobin, has many mitochondria and very many blood capillaries. Type II A cells are red, have a very high capacity for generating ATP by oxidative metabolic processes, split ATP at a very rapid rate, have a fast contraction velocity and are resistant to fatigue. - GOC:tfm + GOC:tfm @@ -62576,7 +62817,7 @@ radial glial cells acting as neural progenitors throughout life. A type II muscle cell that contains a low content of myoglobin, relatively few mitochondria, relatively few blood capillaries and large amounts of glycogen. Type II B fibres are white, geared to generate ATP by anaerobic metabolic processes, not able to supply skeletal muscle fibres continuously with sufficient ATP, fatigue easily, split ATP at a fast rate and have a fast contraction velocity. - GOC:tfm + GOC:tfm ISBN:0517223651 http://en.wikipedia.org/wiki/Skeletal_muscle @@ -62598,7 +62839,7 @@ radial glial cells acting as neural progenitors throughout life. An intermediate muscle cell that has characteristics of both fast and slow muscle cells. - GOC:tfm + GOC:tfm @@ -62619,7 +62860,7 @@ radial glial cells acting as neural progenitors throughout life. A trophoblast that leaves the placenta and invades the endometrium and myometrium. This cell type is crucial in increasing blood flow to the fetus. - GOC:tfm + GOC:tfm http://www.med.yale.edu/obgyn/kliman/placenta/articles/EOR_Placenta/Trophtoplacenta.html @@ -62642,7 +62883,7 @@ radial glial cells acting as neural progenitors throughout life. A double negative thymocyte that has a T cell receptor consisting of a gamma chain that has as part a Vgamma3 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-positive. This cell-type is found in the fetal thymus with highest numbers occurring at E17-E18. - GOC:tfm + GOC:tfm http://www.immgen.org @@ -62662,7 +62903,7 @@ radial glial cells acting as neural progenitors throughout life. A trophoblast found at the junction of the placenta. This cell type makes a unique fibronectin-trophouteronectin junction that helps mediate attachment of the placenta to the uterus. This cell type is also found junction of the chorion layer of the external membranes and the decidua. - GOC:tfm + GOC:tfm http://www.med.yale.edu/obgyn/kliman/placenta/articles/EOR_Placenta/Trophtoplacenta.html @@ -62683,7 +62924,7 @@ radial glial cells acting as neural progenitors throughout life. A cell located between the pinealocytes. - GOC:tfm + GOC:tfm ISBN:0517223651 @@ -62705,7 +62946,7 @@ radial glial cells acting as neural progenitors throughout life. A squamous cell that has keratin in the esophagus. - GOC:tfm + GOC:tfm PMID:11694559 @@ -62734,7 +62975,7 @@ radial glial cells acting as neural progenitors throughout life. A cell comprising the transparent, biconvex body separating the posterior chamber and vitreous body, and constituting part of the refracting mechanism of the mammalian eye. - GOC:tfm + GOC:tfm ISBN:0721662544 @@ -62755,7 +62996,7 @@ radial glial cells acting as neural progenitors throughout life. A cell of the transparent layer of simple cuboidal epithelium over the anterior surface of the lens; transform into lens fiber(s). - GOC:tfm + GOC:tfm ISBN:0517223651 @@ -62800,7 +63041,7 @@ radial glial cells acting as neural progenitors throughout life. A cell of the cuboidal epithelium that covers the lens. The cells of the lens epithelium regulate most of the homeostatic functions of the lens. As ions, nutrients, and liquid enter the lens from the aqueous humor, Na+/K+ ATPase pumps in the lens epithelial cells pump ions out of the lens to maintain appropriate lens osmolarity and volume, with equatorially positioned lens epithelium cells contributing most to this current. The activity of the Na+/K+ ATPases keeps water and current flowing through the lens from the poles and exiting through the equatorial regions. The cells of the lens epithelium also serve as the progenitors for new lens fibers. It constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth. - GOC:tfm + GOC:tfm ISBN:0721662544 http://en.wikipedia.org/wiki/Lens_%28anatomy%29#Lens_epithelium @@ -62828,7 +63069,7 @@ radial glial cells acting as neural progenitors throughout life. A lens fiber cell that develops from primary lens fiber; located towards the center of lens; cell organelles are normally degraded or in the process of being degraded. - GOC:tfm + GOC:tfm ISBN:0517223651 @@ -62856,7 +63097,7 @@ radial glial cells acting as neural progenitors throughout life. A secondary lens fiber cell that lacks a nucleus. - GOC:tfm + GOC:tfm @@ -62877,7 +63118,7 @@ radial glial cells acting as neural progenitors throughout life. A secondary fiber cell that contains a nucleus. - GOC:tfm + GOC:tfm @@ -62904,7 +63145,7 @@ radial glial cells acting as neural progenitors throughout life. An elongating cell that rapidly obliterates the lumen of the lens vesicle. Subsequently, differentiation of this cell type at the lens equator leads to the formation of secondary fiber cells that come to overlie the primary fibers. - GOC:tfm + GOC:tfm PMID:10711704 @@ -62925,7 +63166,7 @@ radial glial cells acting as neural progenitors throughout life. A chief cell that is bigger than dark chief cells and has a larger and lighter nucleus and a cytoplasm with few granules. - GOC:tfm + GOC:tfm ISBN:0721662544 @@ -62973,7 +63214,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell of the prostate. - GOC:tfm + GOC:tfm @@ -63019,7 +63260,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell of prostatic duct. - GOC:tfm + GOC:tfm @@ -63070,7 +63311,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell of the prostatic acinus. - GOC:tfm + GOC:tfm PMCID:PMC2673349 @@ -63111,7 +63352,7 @@ radial glial cells acting as neural progenitors throughout life. A cell of the basal layer of the epithelium in the prostatic acinus. - GOC:tfm + GOC:tfm @@ -63149,7 +63390,7 @@ radial glial cells acting as neural progenitors throughout life. A cell of the luminal layer of the epithelium in the prostatic acinus. - GOC:tfm + GOC:tfm @@ -63188,7 +63429,7 @@ radial glial cells acting as neural progenitors throughout life. A cell that constitutes the basal layer of epithelium in the prostatic duct. - GOC:tfm + GOC:tfm PMID:15226377 @@ -63227,7 +63468,7 @@ radial glial cells acting as neural progenitors throughout life. A cell that constitutes the luminal layer of epithelium of prostatic duct. - GOC:tfm + GOC:tfm @@ -63258,7 +63499,7 @@ radial glial cells acting as neural progenitors throughout life. A primordial germ cell that is destined to become a male germ cell. - GOC:tfm + GOC:tfm @@ -63296,7 +63537,7 @@ radial glial cells acting as neural progenitors throughout life. A primordial cell from which an oocyte (ovum) ultimately is developed. - GOC:tfm + GOC:tfm @@ -63340,7 +63581,7 @@ radial glial cells acting as neural progenitors throughout life. A fibroblast in the bone marrow. - GOC:tfm + GOC:tfm @@ -63395,7 +63636,7 @@ radial glial cells acting as neural progenitors throughout life. A fibroblasts found in interstitial spaces in the pulmonary tract. Greater numbers of these cells are found in idiopathic pulmonary fibrosis. - GOC:tfm + GOC:tfm @@ -63432,7 +63673,7 @@ radial glial cells acting as neural progenitors throughout life. A cell containing at least one nucleus. - GOC:tfm + GOC:tfm @@ -63483,7 +63724,7 @@ radial glial cells acting as neural progenitors throughout life. A circular smooth muscle cell of the iris, innervated by the ciliary nerves (parasympathetic), and acting to contract the pupil. This muscle cell derives from neuroectoderm. This smooth muscle cell results from transformation of epithelial cells to smooth muscle cells. - GOC:tfm + GOC:tfm ISBN:0721662544 ISBN:0721694128 @@ -63507,7 +63748,7 @@ radial glial cells acting as neural progenitors throughout life. A nonstratified squamous cell located in the ectocervix. - GOC:tfm + GOC:tfm http://www.bu.edu/histology/p/19404loa.htm @@ -63528,7 +63769,7 @@ radial glial cells acting as neural progenitors throughout life. OBSOLETE: A lymphocyte that lacks T or B cell surface markers. - GOC:tfm + GOC:tfm ISBN:068340007X @@ -63575,7 +63816,7 @@ radial glial cells acting as neural progenitors throughout life. A hematopoeitic stem cell found in the blood. Normally found in very limited numbers in the peripheral circulation (less than 0.1% of all nucleated cells). - GOC:tfm + GOC:tfm @@ -63595,7 +63836,7 @@ radial glial cells acting as neural progenitors throughout life. A tissue macrophage that is in the pleural space. - GOC:tfm + GOC:tfm @@ -63615,7 +63856,7 @@ radial glial cells acting as neural progenitors throughout life. A pluripotent stem cell has the ability to form cells from all three germ layers (ectoderm, mesoderm, and endoderm). However, unlike totipotent stem cells, they cell can not generate all the cells of the whole organism such as placenta. - GOC:tfm + GOC:tfm PMID:19343304 @@ -63637,7 +63878,7 @@ radial glial cells acting as neural progenitors throughout life. A stem cell that can differentiate into a cardiac myocyte. - GOC:tfm + GOC:tfm PMID:16938308 @@ -63677,7 +63918,7 @@ radial glial cells acting as neural progenitors throughout life. A cell that is found in a zone occupying the bottom region of the crypt; provide the source of most of the cell types of the intestinal epithelium; proliferate by mitotic division; differentiates into columnar or goblet cells. - GOC:tfm + GOC:tfm ISBN:0517223651 @@ -63714,7 +63955,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell of the musculomembranous digestive tube extending from the mouth to the anus. - GOC:tfm + GOC:tfm ISBN:0721662544 @@ -63759,7 +64000,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell of the esophagus. - GOC:tfm + GOC:tfm @@ -63805,7 +64046,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell of the large intestine. - GOC:tfm + GOC:tfm @@ -63849,7 +64090,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell of the small intestine. - GOC:tfm + GOC:tfm @@ -63918,7 +64159,7 @@ radial glial cells acting as neural progenitors throughout life. A supportive cell that has characteristics of glial cell. Processes of this cell envelope the junctions between glomus cells and nerve endings. - GOC:tfm + GOC:tfm PMID:8985136 http://www.copewithcytokines.de/cope.cgi?key=glomus%20cells @@ -63965,7 +64206,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell of thyroid gland. - GOC:tfm + GOC:tfm @@ -63990,7 +64231,7 @@ radial glial cells acting as neural progenitors throughout life. A cell type that varies from squamous to columnar, depending on their activity with microvillus directed luminally. This cell produces and secretes thyroid hormones. - GOC:tfm + GOC:tfm ISBN:0517223651 @@ -64012,7 +64253,7 @@ radial glial cells acting as neural progenitors throughout life. The stem cell from which glial precursor cell arises from. - GOC:tfm + GOC:tfm PMID:11687496 @@ -64052,7 +64293,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell of the parathyroid gland. - GOC:tfm + GOC:tfm @@ -64073,7 +64314,7 @@ radial glial cells acting as neural progenitors throughout life. An endothelial cell found in the mucosa associated with the facial skeleton. - GOC:tfm + GOC:tfm ISBN:0618947256 @@ -64112,7 +64353,7 @@ radial glial cells acting as neural progenitors throughout life. An endothelial cell that lines any of the venous cavities through which blood passes in various glands and organs such as the spleen and liver. - GOC:tfm + GOC:tfm ISBN:0618947256 @@ -64133,7 +64374,7 @@ radial glial cells acting as neural progenitors throughout life. One of three types of epithelial cells that populate the parathyroid gland; cytological characteristics intermediate between those of the chief cell and of the oxyphil cell. Because only one hormone is produced, the three cell forms are widely believed to be different phases in the life cycle of a single cell type, with the chief cell being its physiologically active stage. - GOC:tfm + GOC:tfm ISBN:0412046911 @@ -64166,7 +64407,7 @@ radial glial cells acting as neural progenitors throughout life. A type of enteroendocrine cell found in the stomach that secretes glucagon. - GOC:tfm + GOC:tfm @@ -64202,7 +64443,7 @@ radial glial cells acting as neural progenitors throughout life. A D cell located in the colon. - GOC:tfm + GOC:tfm @@ -64238,7 +64479,7 @@ radial glial cells acting as neural progenitors throughout life. A type D cell of the small intestine. - GOC:tfm + GOC:tfm @@ -64273,7 +64514,7 @@ radial glial cells acting as neural progenitors throughout life. A type D cell found in the stomach. - GOC:tfm + GOC:tfm @@ -64295,7 +64536,7 @@ radial glial cells acting as neural progenitors throughout life. An enteroendocrine cell that stores and secretes Ghrelin. - GOC:tfm + GOC:tfm ISBN:0517223651 PMID:15153415 @@ -64316,7 +64557,7 @@ radial glial cells acting as neural progenitors throughout life. An endocrine cell that secretes vasoactive intestinal peptide. - GOC:tfm + GOC:tfm @@ -64338,7 +64579,7 @@ radial glial cells acting as neural progenitors throughout life. A type EC enteroendocrine cell in the duodenum and jejunum that stores and secretes motilin and 5-hydroxytryptamine. - GOC:tfm + GOC:tfm ISBN:0517223651 PMID:15153415 @@ -64361,7 +64602,7 @@ radial glial cells acting as neural progenitors throughout life. A type EC enteredocrine cell in the intestines that stores and secretes substance P and 5-hydroxytryptamine. - GOC:tfm + GOC:tfm ISBN:0517223651 @@ -64381,7 +64622,7 @@ radial glial cells acting as neural progenitors throughout life. A cell that secretes motilin, a gastric hormone that at low pH inhibits gastric motor activity, whereas at high pH has a stimulating effect. - GOC:tfm + GOC:tfm MESH:D06.472.317.525 @@ -64403,7 +64644,7 @@ radial glial cells acting as neural progenitors throughout life. A type EC enteroendocrine cell type that is numerous in the fundus of the stomach; stores 5-hydroxytryptamine and histamine. - GOC:tfm + GOC:tfm ISBN:0517223651 PMID:15153415 @@ -64441,7 +64682,7 @@ radial glial cells acting as neural progenitors throughout life. A cell type that secretes histamine. - GOC:tfm + GOC:tfm @@ -64489,7 +64730,7 @@ radial glial cells acting as neural progenitors throughout life. A PP cell located in the islets of the pancreas. - GOC:tfm + GOC:tfm @@ -64510,7 +64751,7 @@ radial glial cells acting as neural progenitors throughout life. OBSOLETE: A PP cell located in the pancreatic acinus. Obsoleted due to a lack of published evidence that this cell type is actually found in the pancreatic acinus. - GOC:tfm + GOC:tfm @@ -64532,7 +64773,7 @@ radial glial cells acting as neural progenitors throughout life. An enteroendocrine cell commonest in the duodenum and jejunum, rare in ileum, that secretes cholecystokinin. This cell type is involved in the regulation of digestive enzymes and bile. - GOC:tfm + GOC:tfm @@ -64554,7 +64795,7 @@ radial glial cells acting as neural progenitors throughout life. An enteroendocrine cell of duodenum and jejunum that produces gastric inhibitory peptide. - GOC:tfm + GOC:tfm @@ -64598,7 +64839,7 @@ radial glial cells acting as neural progenitors throughout life. An enteroendorcine cell found in the ileum and jejunum that produces neurotensin. - GOC:tfm + GOC:tfm @@ -64620,7 +64861,7 @@ radial glial cells acting as neural progenitors throughout life. Scattered in duodenojejunal mucosa, this enteroendocrine cell secretes secretin and serotonin. - GOC:tfm + GOC:tfm PMID:15153415 @@ -64643,7 +64884,7 @@ radial glial cells acting as neural progenitors throughout life. An enteroendocrine cell which produces a gastrin- and cholecystokinin-like peptide. The apical microvilli-rich plasma membrane is in open contact with the small intestine mucosa. This cell type is devoid of gastrin-17 but contains other fragments of the gastrin polypeptide. DOI:10.1007/978-3-211-99390-3 - GOC:tfm + GOC:tfm PMID:7013499 @@ -64665,7 +64906,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell of the mucosa associated with facial skeleton. - GOC:tfm + GOC:tfm ISBN:0323052908 @@ -64689,7 +64930,7 @@ radial glial cells acting as neural progenitors throughout life. An enteroendorcine cell found in the fundus and pylorus, this cell type has dense round secretory granules that contain ghrelin. - GOC:tfm + GOC:tfm PMID:20616512 @@ -64713,7 +64954,7 @@ radial glial cells acting as neural progenitors throughout life. A taste receptor cell that is characterized by morphologically identifiable synaptic contacts with the gustatory nerve fibers and expression of the synaptic membrane protein-25 (SNAP-25) and NCAM. - GOC:tfm + GOC:tfm ISBN:0517223651 PMID:15738192 @@ -64736,7 +64977,7 @@ radial glial cells acting as neural progenitors throughout life. A taste receptor cell that has a short microvilli, a projecting apical region, a large rounded nucleus, and expresses taste chemoreceptors thus making them the transducing cell for taste qualities. - GOC:tfm + GOC:tfm PMID:15738192 @@ -64761,7 +65002,7 @@ radial glial cells acting as neural progenitors throughout life. A rounded, mitotically active stem cell which is the source of new cells of the taste bud; located basally. - GOC:tfm + GOC:tfm ISBN:0517223651 PMID:15738192 @@ -64783,7 +65024,7 @@ radial glial cells acting as neural progenitors throughout life. A cell type that forms the boundary with the surrounding epithelium. - GOC:tfm + GOC:tfm ISBN:0517223651 @@ -64808,7 +65049,7 @@ radial glial cells acting as neural progenitors throughout life. A densely staining taste receptor cell that contains many dense vacuoles in their apical regions which project into the apical space and bear microvilli. This cell type serves as a supporting cell by surrounding and isolating the other cell types from each other; secrete a dense amorphous material that surrounds the microvilli in the taste pore. This cell type expresses a glial glutumate transporter, GLAST. - GOC:tfm + GOC:tfm ISBN:0412046911 ISBN:0517223651 PMID:15738192 @@ -64833,7 +65074,7 @@ radial glial cells acting as neural progenitors throughout life. A sperm bearing a Y chromosome. Chromosomal and genetic sex is established at fertilization in mammals and depends upon whether an X-bearing sperm or a Y-bearing sperm fertilizes the X-bearing ovum. - GOC:tfm + GOC:tfm ISBN:0721669743 @@ -64856,7 +65097,7 @@ radial glial cells acting as neural progenitors throughout life. A sperm bearing an X chromosome. Chromosomal and genetic sex is established at fertilization in mammals and depends upon whether an X-bearing sperm or a Y-bearing sperm fertilizes the X-bearing ovum. - GOC:tfm + GOC:tfm ISBN:0721669743 @@ -64878,7 +65119,7 @@ radial glial cells acting as neural progenitors throughout life. A round or oval neuroepithelial cell that contacts other type I cells or capillaries. They occur in clusters that are surrounded by sheath cells (type-II cells) in the carotid body. This cell type is capable of secreting a number of neurotransmitters. - GOC:tfm + GOC:tfm ISBN:0517223651 @@ -64929,7 +65170,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell of the thymus. Epithelial reticular cells are pleomorphic, stellate, non-phagocytic cells which seem to be supportive in function and are held together by desmosomes. They replace the fibroblastoid reticular cells found in other lymphoid organs. Other epithelial cells in the medulla have the ultrastructure of secretory cells. Although different epithelial cells throughout the thymus appear alike by light microscopy their ultrastructure and function varies. FMA:72208 - GOC:tfm + GOC:tfm @@ -64950,7 +65191,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell with a well defined Golgi apparatus that makes up the continuous layer of cells bordering the thymic tissue beneath the capsule. - GOC:tfm + GOC:tfm PMID:9264335 @@ -64974,7 +65215,7 @@ radial glial cells acting as neural progenitors throughout life. A thymic epithelial cell that has an eccentric, round, or irregularly shaped hetero or euchromatic nucleus. The hallmark of this cell type is the presence of vacuoles, which are clustered in one area of the cytoplasm in the vicinity of the nucleus. The vacuoles are small and acquire a grape-like form, occasionally showing delicate internal microvillous projections. - GOC:tfm + GOC:tfm PMID:19721455 PMID:9264335 @@ -64999,7 +65240,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell with high nuclear and cytoplasmic electron-density. This cell type is found in the deeper portions of the cortex but is more abundant in the medulla of the thymus. FMA:0412046911 - GOC:tfm + GOC:tfm PMID:9264335 @@ -65044,7 +65285,7 @@ radial glial cells acting as neural progenitors throughout life. A thymic epithelial cell type with low nuclear and cytoplasmic electrondensity; has a round, euchromatic nucleus and occurs in small groups at the corticomedullary junction or scattered singly in the medulla. - GOC:tfm + GOC:tfm ISBN:0412046911 PMID:19721455 PMID:9264335 @@ -65068,7 +65309,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell scattered in the cortex, predominant in the outer cortex with a large pale nucleus and a prominent nucleolus. - GOC:tfm + GOC:tfm ISBN:0412046911 PMID:9264335 @@ -65091,7 +65332,7 @@ radial glial cells acting as neural progenitors throughout life. A small medullary thymic epithelial cell with a spindle shape, often arranged in groups and connected to each other by large desmosomes and interdigitations. The cytoplasm is sparse, with scanty organelles and thick bundles of cytokeratin. - GOC:tfm + GOC:tfm PMID:19721455 @@ -65112,7 +65353,7 @@ radial glial cells acting as neural progenitors throughout life. A synovial cell type that resembles fibroblasts, has abundant granular endoplasmic reticulum but contains fewer vacuoles and vesicles. This cell type secretes glycoproteins and hyaluronic acid. - GOC:tfm + GOC:tfm ISBN:0517223651 @@ -65134,7 +65375,7 @@ radial glial cells acting as neural progenitors throughout life. A synovial cell that is macrophage-like, characterized by surface ruffles or lamellipodia, plasma membrane invaginations and associated micropinocytotic vesicles, Golgi apparatus and little granular endoplasmic reticulum. - GOC:tfm + GOC:tfm ISBN:0517223651 @@ -65179,7 +65420,7 @@ radial glial cells acting as neural progenitors throughout life. A multi-ciliated cell of the retina that lacks visual pigment and contributes to aqueous humor by secreting chloride ions. This cell type maintains gap junctions with pigmented epithelial cells. - GOC:tfm + GOC:tfm PMID:15106942 @@ -65226,7 +65467,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell of the distal convoluted tubule of the kidney that helps regulate systemic levels of potassium, sodium, calcium, and pH. - GOC:tfm + GOC:tfm ISBN:0517223651 @@ -65274,7 +65515,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell of the proximal tubule of the kidney. - GOC:tfm + GOC:tfm ISBN:1-4160-2328-3 @@ -65294,7 +65535,7 @@ radial glial cells acting as neural progenitors throughout life. A brush border epithelial cell located in the proximal tubule of the kidney that detects fluid flow. - GOC:tfm + GOC:tfm ISBN:1-4160-2328-3 @@ -65333,7 +65574,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell of a skin gland. - GOC:tfm + GOC:tfm @@ -65355,7 +65596,7 @@ radial glial cells acting as neural progenitors throughout life. A basophil chromphil cell of the anterior pitiutary gland that produce adrenocorticotropic hormone, melanocyte-stimulating hormone and lipotropin. This cell type is irregular in shape and has short dendritic processes which are inserted among other neighboring cells; - GOC:tfm + GOC:tfm ISBN:0517223651 @@ -65378,7 +65619,7 @@ radial glial cells acting as neural progenitors throughout life. An acidophil cell of the anterior pitiuatry gland that produces both prolactin and growth hormone. - GOC:tfm + GOC:tfm @@ -65482,7 +65723,7 @@ radial glial cells acting as neural progenitors throughout life. An ecto-epithelial cell of the prostate gland that secretes hormones. - GOC:tfm + GOC:tfm @@ -65502,7 +65743,7 @@ radial glial cells acting as neural progenitors throughout life. An auditory epithelial support cell located in the vestibular epithelium that has many hallmarks of glial cells. This cell type express glial markers such as vimentin, S100, glutamate-aspartate transporter, low affinity neurotrophin receptor p75, glial fibrillary acidic protein, and proteolipid protein. - GOC:tfm + GOC:tfm PMID:20837532 @@ -65541,7 +65782,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial supporting cell located in the cochlea. - GOC:tfm + GOC:tfm @@ -65578,7 +65819,7 @@ radial glial cells acting as neural progenitors throughout life. A supporting cell of the vestibular epithelium. - GOC:tfm + GOC:tfm PMID:20837532 @@ -65599,7 +65840,7 @@ radial glial cells acting as neural progenitors throughout life. An external limiting cell found in the vestibular epithelium. - GOC:tfm + GOC:tfm @@ -65625,7 +65866,7 @@ radial glial cells acting as neural progenitors throughout life. A mesothelial cell capable of circulating in the blood by first losing its squamous character. This cell can incorporate into the regenerating mesothelium. - GOC:tfm + GOC:tfm PMID:14592528 @@ -65665,7 +65906,7 @@ radial glial cells acting as neural progenitors throughout life. A cell that is part of the nervous system. - GOC:tfm + GOC:tfm ISBN:0618947256 @@ -65712,7 +65953,7 @@ radial glial cells acting as neural progenitors throughout life. A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone. - GOC:tfm + GOC:tfm ISBN:0618947256 @@ -65762,7 +66003,7 @@ radial glial cells acting as neural progenitors throughout life. A stem cell of embryonic origin. GOC:dsd - GOC:tfm + GOC:tfm ISBN:068340007X PMID:18179856 @@ -65808,7 +66049,7 @@ radial glial cells acting as neural progenitors throughout life. A cell of a fetus which is suspended in the amniotic fluid. Amniocytes are considered to arise from several tissues including fetal skin, the fetal urinary tract, umbilical cord, and the inner amniotic surface. BFO:0000066 - GOC:tfm + GOC:tfm PMID:3211847 @@ -65828,7 +66069,7 @@ radial glial cells acting as neural progenitors throughout life. A myoepithelial cell that surrounds milk-secreting luminal epithelial cells. This cell type contracts under the stimulation of oxytocin and is attached to the basement membrane by hemidesmosomes and to the adjacent luminal cells by desmosomes. This cell type expresses high level of keratin-14 and is estrogen receptor alpha negative. - GOC:tfm + GOC:tfm PMID:11250738 PMID:19022771 @@ -65880,7 +66121,7 @@ radial glial cells acting as neural progenitors throughout life. The milk-producing cell of the alveolar unit that emerges during pregnancy. - GOC:tfm + GOC:tfm PMID:19022771 @@ -65902,7 +66143,7 @@ radial glial cells acting as neural progenitors throughout life. A mammary epithelial cell that occurs in the lumen of the ductal and alveoli structure in the breast. - GOC:tfm + GOC:tfm PMID:19022771 @@ -65943,7 +66184,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell of the mammary gland. - GOC:tfm + GOC:tfm PMID:19022771 @@ -65981,7 +66222,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell of the bronchus. - GOC:tfm + GOC:tfm @@ -66000,7 +66241,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell type that lacks the columnar shape typical for other respiratory epithelial cells. This cell type is able to differentiate into other respiratory epithelial cells in response to injury. - GOC:tfm + GOC:tfm @@ -66019,7 +66260,7 @@ radial glial cells acting as neural progenitors throughout life. An undifferentiated columnar cell of the bronchus epithelium - GOC:tfm + GOC:tfm PMID:18757316 @@ -66051,7 +66292,7 @@ radial glial cells acting as neural progenitors throughout life. A ciliated cell of the bronchus. - GOC:tfm + GOC:tfm PMID:18757316 @@ -66088,7 +66329,7 @@ radial glial cells acting as neural progenitors throughout life. A fat cell derived from a neural crest cell. - GOC:tfm + GOC:tfm PMID:17507398 @@ -66109,7 +66350,7 @@ radial glial cells acting as neural progenitors throughout life. An undifferentiated fibroblast that can be stimulated to form a fat cell. - GOC:tfm + GOC:tfm PMID:18793119 @@ -66129,7 +66370,7 @@ radial glial cells acting as neural progenitors throughout life. A preadipocyte that is capable of differentiating into a brown adipocyte. This cell type expresses uncoupling protein-1, PPAR-gamma, PR-domain-containing 16; and PGC-1alpha (peroxisome proliferator-activated receptor-gamma (PPARgamma) coactivator-1alpha). - GOC:tfm + GOC:tfm PMID:18719589 @@ -66149,7 +66390,7 @@ radial glial cells acting as neural progenitors throughout life. An endothelial cell that lines the oral cavitiy including the mucosa of the gums, the palate, the lip, and the cheek. - GOC:tfm + GOC:tfm MESH:A10.615.550.599 @@ -66307,7 +66548,7 @@ radial glial cells acting as neural progenitors throughout life. A prostate epithelial cell that is CD133-positive, CD44-positive, integrin A2beta3-high. This cell is a stem cell for the prostate epithelium. - GOC:tfm + GOC:tfm PMID:15226377 @@ -66327,7 +66568,7 @@ radial glial cells acting as neural progenitors throughout life. The exocrine cell of the prostate, this epithelial cell secretes prostatic acid phosphotase and PSA, and is dependent on androgen hormones for survival. - GOC:tfm + GOC:tfm @@ -66346,7 +66587,7 @@ radial glial cells acting as neural progenitors throughout life. An undifferentiated cell of the prostate epithelium that lacks secretory activity. - GOC:tfm + GOC:tfm PMCID:PMC2673349 @@ -66366,7 +66607,7 @@ radial glial cells acting as neural progenitors throughout life. A circulating endothelial cell of the phenotype CD146-positive, CD105-positive, CD45-negative. This cell type is indicative of recent vascular damage. - GOC:tfm + GOC:tfm PMID:19652886 @@ -66627,7 +66868,7 @@ radial glial cells acting as neural progenitors throughout life. An immature natural killer cell that is NK1.1-positive, DX5-positive, Ly49-positive, CD27-low and CD11b-low. This cell type is found in high numbers in the liver. - GOC:tfm + GOC:tfm PMID:19949422 http:www.immgen.org/index_content.html @@ -66685,7 +66926,7 @@ radial glial cells acting as neural progenitors throughout life. An immature natural killer cell that is NK1.1-positive and DX-5 negative. - GOC:tfm + GOC:tfm PMID:12766763 @@ -66752,7 +66993,7 @@ radial glial cells acting as neural progenitors throughout life. A mature natural killer cell that is CD27-high and CD11b-high. This cell type is capable of interferon-gamma secretion. - GOC:tfm + GOC:tfm PMID:19949422 @@ -66815,7 +67056,7 @@ radial glial cells acting as neural progenitors throughout life. A CD27-low, CD11b-high natural killer cell that has a higher threshold of activation due to higher expression of inhibitory receptors. - GOC:tfm + GOC:tfm PMID:1994922 @@ -66878,7 +67119,7 @@ radial glial cells acting as neural progenitors throughout life. A natural killer cell that is CD27-high and CD11b-low. - GOC:tfm + GOC:tfm PMID:1994922 @@ -66919,7 +67160,7 @@ radial glial cells acting as neural progenitors throughout life. An endothelial cell that lines the intracavitary lumen of the heart, separating the circulating blood from the underlying myocardium. This cell type releases a number of vasoactive substances including prostacyclin, nitrous oxide and endothelin. - GOC:tfm + GOC:tfm ISSN:0452-3458 @@ -66947,7 +67188,7 @@ radial glial cells acting as neural progenitors throughout life. A multi-fate stem cell that is able to differentiate into the pancreas alpha, beta and delta endocrine cells. This cell type expresses neurogenin-3 and Isl-1. - GOC:tfm + GOC:tfm PMID:20025937 PMID:20217494 @@ -66985,7 +67226,7 @@ radial glial cells acting as neural progenitors throughout life. A hematopoietic stem cell that exists during embryogenesis. - GOC:tfm + GOC:tfm ISBN:978-60327-246-6 @@ -67104,7 +67345,7 @@ radial glial cells acting as neural progenitors throughout life. A hematopoietic stem cell that resides in the fetal liver. In mice, this cell type is first observed at E10.5. This cell type is MHC-positive, HSA-positive, AA4.1-positive, CD45-positive, Sca-1 positive, CD150-positive, CD48-negative and CD244-negative. - GOC:tfm + GOC:tfm ISBN:978-1-60327-346-6 PMID:16569764 @@ -67206,7 +67447,7 @@ radial glial cells acting as neural progenitors throughout life. A hematopoietic stem found in the yolk sac. In mice, this cell type is Sca-1-negative, CD45-negative, MHC-negative, HSA-positive, AA4.1-positive, CD44-positive. - GOC:tfm + GOC:tfm doi:10.1097/MOH.0b013e3282f97ae1 @@ -67289,7 +67530,7 @@ radial glial cells acting as neural progenitors throughout life. A large nucleated basophilic erythrocyte found in mammalian embryos. This cell type arises from the blood islands of yolk sacs and expresses different types of hemoglobins (beta-H1, gamma-1 and zeta) than adult erythrocytes. Considered a type of erythroblast as this cell type can enucleate in circulation. DOI:10.1097/MOH.0b013e3282f97ae1 - GOC:tfm + GOC:tfm PMID:11495698 @@ -67343,7 +67584,7 @@ radial glial cells acting as neural progenitors throughout life. A primitive erythrocyte that has undergone enucleation. This cell type is 3-6 fold bigger than the fetal derived erythrocytes that they co-circulate with during fetal development. Expresses epsilon-gamma hemoglobin chains. - GOC:tfm + GOC:tfm PMID:11495698 doi:10.1097/MOH.0b013e3282f97ae1 @@ -67404,7 +67645,7 @@ radial glial cells acting as neural progenitors throughout life. A fetal liver derived enucleated erythrocyte. This erythrocyte resembles adult erythrocytes in that they are small (3- to 6- times smaller than primitive erythrocytes) and produce adult hemaglobins. - GOC:tfm + GOC:tfm PMID:11495698 @@ -67457,7 +67698,7 @@ radial glial cells acting as neural progenitors throughout life. Derived from the Greek word pyren (the pit of a stone fruit), this is a transient nucleated cell type that results from exclusion of the nucleus from the primitive erythrocyte. - GOC:tfm + GOC:tfm @@ -67493,7 +67734,7 @@ radial glial cells acting as neural progenitors throughout life. A hematopoietic stem cell of the placenta. This cell type is first observed E10.5 This cell type may give rise to fetal liver hematopoietic stem cells. - GOC:tfm + GOC:tfm ISBN:978-1-60327-346-6 @@ -67513,7 +67754,7 @@ radial glial cells acting as neural progenitors throughout life. A hematopoietic stem cell from the aorta-gonad-mesonephros region of the developing embryo. First seen at E10.5 in mouse embryos. May give rise to fetal liver HSC. - GOC:tfm + GOC:tfm ISBN:978-1-60327-346-6 @@ -67564,7 +67805,7 @@ radial glial cells acting as neural progenitors throughout life. A progenitor cell that is capable of forming colonies of primitive erythrocytes in the blood island of the yolk sac. First arrive at E7.5 in mouse and expresses CD41. - GOC:tfm + GOC:tfm ISBN:0813817986 PMID:20711979 @@ -67585,7 +67826,7 @@ radial glial cells acting as neural progenitors throughout life. A cell located in the outermost proliferative zone of the external germinal layer that can differentiate into astroglial cells and granule cells. This cell type is glial fibrillary acidic protein-positive and NK1-positive. - GOC:tfm + GOC:tfm PMID:14745007 @@ -67624,7 +67865,7 @@ radial glial cells acting as neural progenitors throughout life. A keratocyte is a specialized fibroblast residing in the cornea stroma that has a flattened, dendritic cell located between the lamellae with a large flattened nucleus and lengthy processes which communicate with neighboring cells. This corneal layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components. This cell type secretes collagen I, V, VI, and keratin sulfate. - GOC:tfm + GOC:tfm ISBN:978-0-7020-2958-5 @@ -67663,7 +67904,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell of the cortical portion of the thymus. Epithelial cells in this region are required for positive selection of CD8-positive T cells. - GOC:tfm + GOC:tfm PMID:18403190 @@ -67702,7 +67943,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell of the medullary thymus. This cell type expresses a diverse range of tissue-specific antigens. This promiscuous gene expression is a cell-autonomous property of medullary epithelial cells and is maintained during the entire period of thymic T cell output. - GOC:tfm + GOC:tfm PMID:18180458 @@ -67741,7 +67982,7 @@ radial glial cells acting as neural progenitors throughout life. A smooth muscle cell of the myometrium that enlarges and stretches during pregnancy, and contracts in response to oxytocin. - GOC:tfm + GOC:tfm PMID:11429640 @@ -67785,7 +68026,7 @@ radial glial cells acting as neural progenitors throughout life. A cell that lines the trabecular meshwork, which is an area of tissue in the eye located around the base of the cornea, near the ciliary body, and is responsible for draining the aqueous humor from the eye via the anterior chamber (the chamber on the front of the eye covered by the cornea). This cell may play a role in regulating intraocular pressure. - GOC:tfm + GOC:tfm PMID:14500801 @@ -67830,7 +68071,7 @@ radial glial cells acting as neural progenitors throughout life. An endo-epithelial cell of the respiratory tract. - GOC:tfm + GOC:tfm @@ -67850,7 +68091,7 @@ radial glial cells acting as neural progenitors throughout life. A differentiated form of a fungus produced during or as a result of an asexual or sexual reproductive process; usually a cell with a thick cell wall that stores and protects one or more nuclei. Spores may be produced in response to, and are characteristically resistant to, adverse environmental conditions. FAO:0000019 - GOC:tfm + GOC:tfm @@ -67887,7 +68128,7 @@ radial glial cells acting as neural progenitors throughout life. A simple columnar epithelial cell that secretes mucin. Rough endoplasmic reticulum, mitochondria, the nucleus, and other organelles are concentrated in the basal portion. The apical plasma membrane projects microvilli to increase surface area for secretion. - GOC:tfm + GOC:tfm ISBN:0721662544 @@ -67917,7 +68158,7 @@ radial glial cells acting as neural progenitors throughout life. A cell of an organism that does not pass on its genetic material to the organism's offspring (i.e. a non-germ line cell). - GOC:tfm + GOC:tfm ISBN:0721662544 @@ -67967,7 +68208,7 @@ radial glial cells acting as neural progenitors throughout life. A transversely striated, synctial muscle cell, formed by the fusion of myoblasts. GOC:dos - GOC:tfm + GOC:tfm ISBN:0323052908 PMID:22274696 @@ -67991,7 +68232,7 @@ radial glial cells acting as neural progenitors throughout life. A peptide hormone secreting cell that secretes growth hormone releasing hormone. GOC:dph - GOC:tfm + GOC:tfm @@ -68012,7 +68253,7 @@ radial glial cells acting as neural progenitors throughout life. A hair cell of the ear that contains the organs of balance and hearing. GOC:dph - GOC:tfm + GOC:tfm ISBN:0192801023 @@ -68040,7 +68281,7 @@ radial glial cells acting as neural progenitors throughout life. A giioblast cell that develops from a migratory neural crest cell. The SCP is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has no basal lamina. In rodents SCPs are the only cells in the Schwann cell linage that expresses Cdh19. - GOC:tfm + GOC:tfm @@ -68067,7 +68308,7 @@ radial glial cells acting as neural progenitors throughout life. A glial cell that ensheaths multiple small diameter axons in the peripheral nervous system. The non-myelinating Schwann cell is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has a basal lamina. Cells can survive without an axon present. These cells can de-differentiate into immature Schwann cells. GOC:cvs - GOC:tfm + GOC:tfm ISBN:0721662544 @@ -68096,7 +68337,7 @@ radial glial cells acting as neural progenitors throughout life. A glial cell that develops from a Schwann cell precursor. The immature Schwann cell is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has a basal lamina. Cells can survive without an axon present. Immature Schwann cell can be found communally ensheathing large groups of axons. GOC:cvs - GOC:tfm + GOC:tfm ISBN:0721662544 @@ -68118,7 +68359,7 @@ radial glial cells acting as neural progenitors throughout life. A double negative thymocyte that has a T cell receptor consisting of a gamma chain containing a Vgamma2 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-positive and is found in the fetal thymus. - GOC:tfm + GOC:tfm http://www.immgen.org @@ -68140,7 +68381,7 @@ radial glial cells acting as neural progenitors throughout life. A neurecto-epithelial cell found in the arachnoid villi of dura mater. This cell type facilitates flow of cerebrospinal fluid into the blood. - GOC:tfm + GOC:tfm http://www.aippg.net/forum/viewtopic.php?t=62590 @@ -68161,7 +68402,7 @@ radial glial cells acting as neural progenitors throughout life. An asexual spore formed by Oomycetes; formed upon fertilization of an oosphere. - GOC:tfm + GOC:tfm ISBN:0851988857 SGD:clt @@ -68183,7 +68424,7 @@ radial glial cells acting as neural progenitors throughout life. A conidium that has only one nucleus. - GOC:tfm + GOC:tfm SGD:clt @@ -68204,7 +68445,7 @@ radial glial cells acting as neural progenitors throughout life. A conidium that has more than one nucleus. - GOC:tfm + GOC:tfm SGD:clt @@ -68223,7 +68464,7 @@ radial glial cells acting as neural progenitors throughout life. A uninucleate spore formed on specialized cells or projections, sterigma, of a conidiophore head. - GOC:tfm + GOC:tfm PMID:9529886 SGD:clt @@ -68244,7 +68485,7 @@ radial glial cells acting as neural progenitors throughout life. A macroconidium that has only one nucleus. - GOC:tfm + GOC:tfm SGD:clt @@ -68265,7 +68506,7 @@ radial glial cells acting as neural progenitors throughout life. An oblong or round asexual spore formed from conidial chains. - GOC:tfm + GOC:tfm PMID:2524423 SGD:clt @@ -68286,7 +68527,7 @@ radial glial cells acting as neural progenitors throughout life. A macroconidium that has more than one nucleus. - GOC:tfm + GOC:tfm SGD:clt @@ -68306,7 +68547,7 @@ radial glial cells acting as neural progenitors throughout life. Cylindrical spore formed by development and compartmentation of hyphae; the hyphae are often supporting blastoconidiophores. - GOC:tfm + GOC:tfm PMID:2524423 SGD:clt @@ -68327,7 +68568,7 @@ radial glial cells acting as neural progenitors throughout life. An arthroconidium that has more than one nucleus. - GOC:tfm + GOC:tfm SGD:clt @@ -68347,7 +68588,7 @@ radial glial cells acting as neural progenitors throughout life. An arthroconidium that has only one nucleus. - GOC:tfm + GOC:tfm SGD:clt @@ -68367,7 +68608,7 @@ radial glial cells acting as neural progenitors throughout life. A blastoconidium that has only one nucleus. - GOC:tfm + GOC:tfm SGD:clt @@ -68387,7 +68628,7 @@ radial glial cells acting as neural progenitors throughout life. A blastoconidium that has more than one nucleus. - GOC:tfm + GOC:tfm SGD:clt @@ -68406,7 +68647,7 @@ radial glial cells acting as neural progenitors throughout life. Obsolete. Use PO:0025017 from Plant Ontology instead. A plant cell that arises through meiosis and develops into a gametophyte. - GOC:tfm + GOC:tfm PO:0025017 @@ -68489,7 +68730,7 @@ radial glial cells acting as neural progenitors throughout life. A monocyte that has characteristics of both patrolling and inflammatory monocytes. - GOC:tfm + GOC:tfm PMID:20628149 PMID:20870168 @@ -68560,7 +68801,7 @@ radial glial cells acting as neural progenitors throughout life. A myeloid dendritic cell found in the blood, lymph nodes, tonsil, bone marrow, and spleen that is CD141-positive (BDCA-3), XCR1-positive, and Clec9A-positive. This cell-type can cross-present antigen to CD8-positive T cells and can produce inteferon-beta. GOC:dsd - GOC:tfm + GOC:tfm PMCID:PMC2882828 PMCID:PMC2882837 PMID:17332250 @@ -68646,7 +68887,7 @@ radial glial cells acting as neural progenitors throughout life. A resident monocyte that is Gr-1 high, CD43-negative, CX3CR1-negative, CD115-positive, and B220-negative. - GOC:tfm + GOC:tfm PMID:20628149 PMID:8890901 http://www.immgen.org/index_content.html @@ -68710,7 +68951,7 @@ radial glial cells acting as neural progenitors throughout life. A patrolling monocyte that is CD14-low and CD16-positive. - GOC:tfm + GOC:tfm PMID:20870168 @@ -68759,7 +69000,7 @@ radial glial cells acting as neural progenitors throughout life. A CD14-positive monocyte that is also CD16-positive and CCR2-negative. - GOC:tfm + GOC:tfm PMID:20628149 PMID:21937707 PMID:22343568 @@ -68829,7 +69070,7 @@ radial glial cells acting as neural progenitors throughout life. An intermediate monocyte that is Gr1-positive, CD43-positive. - GOC:tfm + GOC:tfm PMID:20628149 @@ -68884,7 +69125,7 @@ radial glial cells acting as neural progenitors throughout life. A myeloid dendritic cell found in the blood that is CD1c-positive. GOC:dsd - GOC:tfm + GOC:tfm PMID:20204387 PMID:20628149 @@ -68956,7 +69197,7 @@ radial glial cells acting as neural progenitors throughout life. A precursor B cell that is AA4-positive, IgM-negative, CD19-positive, CD43-positive and HSA-positive. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -68985,7 +69226,7 @@ radial glial cells acting as neural progenitors throughout life. A thymocyte that has a T cell receptor consisting of a gamma chain that has as part a Vgamma3 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus with highest numbers occurring at E17-E18. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -69076,7 +69317,7 @@ radial glial cells acting as neural progenitors throughout life. A resting mature B cell within the Peyer's patch that is CD19-positive, B220-positive, IgM-positive, AA4-negative, CD23-positive, CD43-negative, and CD5-negative. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -69104,7 +69345,7 @@ radial glial cells acting as neural progenitors throughout life. A thymocyte that has a T cell receptor consisting of a gamma chain containing Vgamma2 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -69124,7 +69365,7 @@ radial glial cells acting as neural progenitors throughout life. A thymocyte found in the fetal thymus. - GOC:tfm + GOC:tfm @@ -69165,7 +69406,7 @@ radial glial cells acting as neural progenitors throughout life. A post-natal thymocyte expressing components of the gamma-delta T cell receptor. This cell type is always double-negative (i.e. CD4-negative, CD8-negative). - GOC:tfm + GOC:tfm PMID:20725107 @@ -69187,7 +69428,7 @@ radial glial cells acting as neural progenitors throughout life. A double negative post-natal thymocyte that has a T cell receptor consisting of a gamma chain containing a Vgamma2 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-positive. - GOC:tfm + GOC:tfm http://www.immgen.org @@ -69215,7 +69456,7 @@ radial glial cells acting as neural progenitors throughout life. A thymocyte that has a T cell receptor consisting of a gamma chain containing Vgamma2 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-negative. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -69237,7 +69478,7 @@ radial glial cells acting as neural progenitors throughout life. A double negative post-natal thymocyte that has a T cell receptor consisting of a gamma chain that does not contain a Vgamma2 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-positive. - GOC:tfm + GOC:tfm http://www.immgen.org @@ -69265,7 +69506,7 @@ radial glial cells acting as neural progenitors throughout life. A thymocyte that has a T cell receptor consisting of a gamma chain that does not contain the Vgamma2 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-negative. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -69294,7 +69535,7 @@ radial glial cells acting as neural progenitors throughout life. A cell that is found in the periacinar space of the exocrine pancreas and in perivascular and periductal regions of the pancreas, and has long cytoplasmic processes that encircle the base of the acinus. Expresses several intermediate filament proteins including vimentin and nestin. Shares many of the characteristics of hepatatic stellate cells, but not stellate cells of the central nervous system. Upon activation, this cell type undergoes morphological and gene expression changes that make the cell suggestive of being a type of myofibroblast. GOC:mah - GOC:tfm + GOC:tfm PMID:17200706 @@ -69315,7 +69556,7 @@ radial glial cells acting as neural progenitors throughout life. A gamma-delta receptor that expresses Vgamma1.1 but does not express Vdelta6.3 chains in the T-cell receptor. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -69336,7 +69577,7 @@ radial glial cells acting as neural progenitors throughout life. A gamma-delta receptor that expresses Vgamma1.1-Vdelta6.3 chains in the T-cell receptor. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -69357,7 +69598,7 @@ radial glial cells acting as neural progenitors throughout life. A Vgamma1.1-positive, Vdelta6.3-negative thymocyte that is CD24-negative. - GOC:tfm + GOC:tfm http://www.immgen.org @@ -69378,7 +69619,7 @@ radial glial cells acting as neural progenitors throughout life. A Vgamma1.1-positive, Vdelta6.3-negative thymocyte that is CD24-positive. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -69399,7 +69640,7 @@ radial glial cells acting as neural progenitors throughout life. A Vgamma1.1-positive, Vdelta6.3-positive thymocyte that is CD24-positive. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -69420,7 +69661,7 @@ radial glial cells acting as neural progenitors throughout life. A Vgamma1.1-positive, Vdelta6.3-positive thymocyte that is CD24-negative. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -69440,7 +69681,7 @@ radial glial cells acting as neural progenitors throughout life. An immature or mature cell of the first erythroid lineage to arise during embryonic development. - GOC:tfm + GOC:tfm @@ -69465,7 +69706,7 @@ radial glial cells acting as neural progenitors throughout life. A pluripotent cell in the yolk sac that can give rise to mesenchymal cells including erythrocytes and endothelial cells. - GOC:tfm + GOC:tfm ISBN:0813817986 PMID:11495698 @@ -69522,7 +69763,7 @@ radial glial cells acting as neural progenitors throughout life. A T cell that expresses a T cell receptor complex and has completed T cell selection. - GOC:tfm + GOC:tfm @@ -69567,7 +69808,7 @@ radial glial cells acting as neural progenitors throughout life. A T cell that has not completed T cell selection. - GOC:tfm + GOC:tfm @@ -69604,7 +69845,7 @@ radial glial cells acting as neural progenitors throughout life. A reticulocyte that retains the nucleus and other organelles. Found in birds, fish, amphibians and reptiles. - GOC:tfm + GOC:tfm PMID:18182572 PMID:9011180 PMID:9046052 @@ -69656,7 +69897,7 @@ radial glial cells acting as neural progenitors throughout life. A reticulocyte lacking a nucleus and showing a basophilic reticulum under vital staining due to the presence of ribosomes. - GOC:tfm + GOC:tfm ISBN:0-12203-052-4 ISBN:0721601464 @@ -69701,7 +69942,7 @@ radial glial cells acting as neural progenitors throughout life. A DN2 thymocyte that is Kit-hi. - GOC:tfm + GOC:tfm PMID:20595614 @@ -69751,7 +69992,7 @@ radial glial cells acting as neural progenitors throughout life. A DN2 thymocyte that is Kit-low. - GOC:tfm + GOC:tfm PMID:20595614 @@ -69828,7 +70069,7 @@ radial glial cells acting as neural progenitors throughout life. A pro-T cell that is lin-negative, CD25-negative, CD127-negative, CD44-positive and kit-positive. GOC:dsd - GOC:tfm + GOC:tfm PMID:16551251 http://www.immgen.org/index_content.html @@ -69881,7 +70122,7 @@ radial glial cells acting as neural progenitors throughout life. A mature natural killer cell that is CD11b-positive and CD27-positive. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -69925,7 +70166,7 @@ radial glial cells acting as neural progenitors throughout life. A double-positive, alpha-beta thymocyte that is small and not proliferating. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -69986,7 +70227,7 @@ radial glial cells acting as neural progenitors throughout life. A double-positive thymocyte that is large (i.e. has a high forward scatter signal in flow cytometry) and is actively proliferating. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -70056,7 +70297,7 @@ radial glial cells acting as neural progenitors throughout life. A double-positive thymocyte that is CD69-positive and has begun positive selection. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -70136,7 +70377,7 @@ radial glial cells acting as neural progenitors throughout life. A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD4 co-receptor. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -70216,7 +70457,7 @@ radial glial cells acting as neural progenitors throughout life. A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD8 co-receptor. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -70278,7 +70519,7 @@ radial glial cells acting as neural progenitors throughout life. A CD4-positive, CD8-negative thymocyte that is CD24-positive and expresses high levels of the alpha-beta T cell receptor. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -70339,7 +70580,7 @@ radial glial cells acting as neural progenitors throughout life. A CD4-positive, CD8-negative thymocyte that expresses high levels of the alpha-beta T cell receptor and is CD69-positive. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -70401,7 +70642,7 @@ radial glial cells acting as neural progenitors throughout life. A CD8-positive, CD4-negative thymocyte that is CD24-positive and expresses high levels of the alpha-beta T cell receptor. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -70462,7 +70703,7 @@ radial glial cells acting as neural progenitors throughout life. A CD8-positive, CD4-negative thymocyte that expresses high levels of the alpha-beta T cell receptor and is CD69-positive. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html https://orcid.org/0000-0001-5208-3432 @@ -70523,7 +70764,7 @@ radial glial cells acting as neural progenitors throughout life. A mature CD4-positive, CD8-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -70583,7 +70824,7 @@ radial glial cells acting as neural progenitors throughout life. A mature CD8-positive, CD4-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor. - GOC:tfm + GOC:tfm http:www.immgen.org/index_content.html @@ -70633,7 +70874,7 @@ radial glial cells acting as neural progenitors throughout life. A mature NK cell that is NK1.1-positive. - GOC:tfm + GOC:tfm @@ -70674,7 +70915,7 @@ radial glial cells acting as neural progenitors throughout life. A NK1.1-positive T cell that is NKGA2-positive. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -70716,7 +70957,7 @@ radial glial cells acting as neural progenitors throughout life. A NK1.1-positive T cell that is Ly49D-positive. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -70758,7 +70999,7 @@ radial glial cells acting as neural progenitors throughout life. A NK1.1-positive T cell that is CD94-positive. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -70817,7 +71058,7 @@ radial glial cells acting as neural progenitors throughout life. A NK1.1-positive T cell that is CD94-negative and Ly49Cl-negative. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -70860,7 +71101,7 @@ radial glial cells acting as neural progenitors throughout life. A NK1.1-positive T cell that is Ly49Cl-positive. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -70902,7 +71143,7 @@ radial glial cells acting as neural progenitors throughout life. A NK1.1-positive T cell that is Ly49H-positive. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -70944,7 +71185,7 @@ radial glial cells acting as neural progenitors throughout life. A NK1.1-positive T cell that is Ly49D-negative. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -70987,7 +71228,7 @@ radial glial cells acting as neural progenitors throughout life. A NK1.1-positive T cell that is Ly49Cl-negative. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -71029,7 +71270,7 @@ radial glial cells acting as neural progenitors throughout life. A NK1.1-positive T cell that is CD94-negative. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -71071,7 +71312,7 @@ radial glial cells acting as neural progenitors throughout life. A NK1.1-positive T cell that is Ly49H-negative. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -71112,7 +71353,7 @@ radial glial cells acting as neural progenitors throughout life. A NK1.1-positive T cell that is CD94-positive and Ly49Cl-positive. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -71133,7 +71374,7 @@ radial glial cells acting as neural progenitors throughout life. A specialized hair cell that has an elongated kinocilium upon which an otolith accretes. The tether cell then anchors the otolith in place. GOC:cvs - GOC:tfm + GOC:tfm PMID:9398434 @@ -71154,7 +71395,7 @@ radial glial cells acting as neural progenitors throughout life. A multi-fate stem cell that is the source of cells for growth of the mammary gland during puberty and gestation. This cell type gives rise to both the luminal and myoepithelial cell types of the gland, and have been shown to have the ability to regenerate the entire organ in mice. This cell type also plays an important role in carcinogenesis of the breast. This cell type is Lin-, CD24-positive, CD29-hi. GOC:hjd - GOC:tfm + GOC:tfm PMID:15987436 PMID:16397499 PMID:17851544 @@ -71205,7 +71446,7 @@ radial glial cells acting as neural progenitors throughout life. The cell type from which oligodendrocytes develop. This cell originates from multiple structures within the developing brain including the medial ganglion eminence and the lateral ganglionic eminence. These cells migrate throughout the central nervous system and persist into adulthood where they play an important role in remyelination of injured neurons. - GOC:tfm + GOC:tfm PMID:20142420 @@ -71260,7 +71501,7 @@ radial glial cells acting as neural progenitors throughout life. Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-negative, CD8_alpha-negative and is CD205-positive. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -71314,7 +71555,7 @@ radial glial cells acting as neural progenitors throughout life. A CD11c-low plasmacytoid dendritic cell that is CD8alpha-negative and CD4-positive. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -71368,7 +71609,7 @@ radial glial cells acting as neural progenitors throughout life. A CD11c-low plasmacytoid dendritic cell that is CD8alpha-positive and CD4-positive. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -71436,7 +71677,7 @@ radial glial cells acting as neural progenitors throughout life. A Langerhans cell that is in the epidermis and is CD45-positive, MHCII-positive, and CD11b-positive. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -71474,7 +71715,7 @@ radial glial cells acting as neural progenitors throughout life. A dermal dendritic cell that is langerin-positive and CD103-positive. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -71543,7 +71784,7 @@ radial glial cells acting as neural progenitors throughout life. A dermal dendritic cell that is langerin-negative, CD103-negative, and CD11b-positive. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -71587,7 +71828,7 @@ radial glial cells acting as neural progenitors throughout life. A conventional thymic dendritic cell that is CD8alpha-negative. - GOC:tfm + GOC:tfm PMID:19273629 http://www.immgen.org/index_content.html @@ -71638,7 +71879,7 @@ radial glial cells acting as neural progenitors throughout life. A conventional dendritic cell that is CD103-positive. This cell type is usually found in non-lymphoid tissue. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -71699,7 +71940,7 @@ radial glial cells acting as neural progenitors throughout life. A F4/80-negative dendritic cell located in adipose tissue. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -71737,7 +71978,7 @@ radial glial cells acting as neural progenitors throughout life. An adipose dendritic cell that is SIRPa-positive. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -71775,7 +72016,7 @@ radial glial cells acting as neural progenitors throughout life. An adipose dendritic cell that is SIRPa-negative. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -71818,7 +72059,7 @@ radial glial cells acting as neural progenitors throughout life. A conventional dendritic cell that expresses CD11b (ITGAM). - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -71892,7 +72133,7 @@ radial glial cells acting as neural progenitors throughout life. A CD11b-positive dendritic cell located in the serosal portion of the small intestine epithelium. This cell type is CD45-positive, MHC-II-positive, CD11c-low, CD103-negative. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -71946,7 +72187,7 @@ radial glial cells acting as neural progenitors throughout life. A myeloid suppressor cell that is Gr1-high and CD11c-negative. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -72000,7 +72241,7 @@ radial glial cells acting as neural progenitors throughout life. A myeloid suppressor cell that is Gr1-low and CD11c-positive. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -72044,7 +72285,7 @@ radial glial cells acting as neural progenitors throughout life. Gr1-high monocyte that lacks MHC-II receptor complex. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -72088,7 +72329,7 @@ radial glial cells acting as neural progenitors throughout life. Gr1-high monocyte that has a MHC-II receptor complex. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -72132,7 +72373,7 @@ radial glial cells acting as neural progenitors throughout life. Gr1-low non-classical monocyte that lacks expression of a MHC-II complex. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -72176,7 +72417,7 @@ radial glial cells acting as neural progenitors throughout life. Gr1-low non-classical monocyte that has low to intermediate expression of the MHC-II complex. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -72220,7 +72461,7 @@ radial glial cells acting as neural progenitors throughout life. Gr1-low non-classical monocyte that has high surface expression of a MHC-II complex. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -72283,7 +72524,7 @@ radial glial cells acting as neural progenitors throughout life. A MHC-II-negative classical monocyte located in lymphoid tissue that is F4/80-positive, CD11c-negative, and CD11b-high. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -72340,7 +72581,7 @@ radial glial cells acting as neural progenitors throughout life. A MHC-II-negative classical monocyte located in lymphoid tissue that is F4/80-positive, CD11c-intermediate, and CD11b-high. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -72426,7 +72667,7 @@ radial glial cells acting as neural progenitors throughout life. A tissue-resident macrophage located in the bone marrow. This cell type is B220-negative, CD3e-negative, Ly-6C-negative, CD115-positive, F4/80-positive. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -72489,7 +72730,7 @@ radial glial cells acting as neural progenitors throughout life. A macrophage located in adipose tissue that is CD45-positive, CD11c-positive, and SIRPa-positive. - GOC:tfm + GOC:tfm @@ -72542,7 +72783,7 @@ radial glial cells acting as neural progenitors throughout life. An adipose macrophage that does not express F4/80but is MHC-II-positive. This cell type exhibits autofluorescence under typical flow cyometry conditions. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -72596,7 +72837,7 @@ radial glial cells acting as neural progenitors throughout life. An adipose macrophage that does not express MHC-II but is F4/80-positive. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -72635,7 +72876,7 @@ radial glial cells acting as neural progenitors throughout life. A goblet cell located in the nasal epithelium. GOC:cjm - GOC:tfm + GOC:tfm @@ -72673,7 +72914,7 @@ radial glial cells acting as neural progenitors throughout life. The flattened smooth myoepithelial cells of mesodermal origin that lie just outside the basal lamina of the seminiferous tubule. GOC:cjm - GOC:tfm + GOC:tfm MP:0006420 @@ -72711,7 +72952,7 @@ radial glial cells acting as neural progenitors throughout life. A melanocyte that produces pigment in the dermis. GOC:cjm - GOC:tfm + GOC:tfm MP:0009386 @@ -72743,7 +72984,7 @@ radial glial cells acting as neural progenitors throughout life. A melanocyte that produces pigment within the hair follicle. - GOC:tfm + GOC:tfm MP:0004381 @@ -72787,7 +73028,7 @@ radial glial cells acting as neural progenitors throughout life. A melanocyte that produces pigment in the epithelium. - GOC:tfm + GOC:tfm MP:0009388 @@ -72830,7 +73071,7 @@ radial glial cells acting as neural progenitors throughout life. A melanocyte of the retina. This cell type is distinct from pigmented retinal epithelium. - GOC:tfm + GOC:tfm MP:0010190 @@ -72869,7 +73110,7 @@ radial glial cells acting as neural progenitors throughout life. A melanocyte located between the epithelial marginal cell layer and the mesodermal basal cell layer within the intrastrial space; the predominant cellular component of the electrogenic machinery that generates an endocochlear potential (80-100 mV) . - GOC:tfm + GOC:tfm MP:0000048 @@ -72889,7 +73130,7 @@ radial glial cells acting as neural progenitors throughout life. A neuronal receptor that respond to mechanical pressure or distortion in the skin. - GOC:tfm + GOC:tfm MP:0000973 @@ -72943,7 +73184,7 @@ radial glial cells acting as neural progenitors throughout life. A trophoblast cell that has a large volume of cytoplasm, is polyploid and is usually mononuclear but is also occasionally multi-nucleate. This cell type is important in establishing maternal physiology and remodeling of the vasculature of the placenta. - GOC:tfm + GOC:tfm MP:0001714 MP:19876834 @@ -73000,7 +73241,7 @@ radial glial cells acting as neural progenitors throughout life. A thymocyte that lacks expression of CD4 and CD8. - GOC:tfm + GOC:tfm MP:0002407 @@ -73043,7 +73284,7 @@ radial glial cells acting as neural progenitors throughout life. A supporting cell of the organ of Corti. - GOC:tfm + GOC:tfm MP:0004300 @@ -73080,7 +73321,7 @@ radial glial cells acting as neural progenitors throughout life. A specialized cell involved in auditory sensory perception. - GOC:tfm + GOC:tfm @@ -73099,7 +73340,7 @@ radial glial cells acting as neural progenitors throughout life. A polarized columnar cell that covesr the lateral surface of the cochlear duct, secretes potassium ions and forms a continuous sheet in contact with the endolymph; marginal cells form extensive interdigitations with the basal and intermediate cells in the normal adult stria. - GOC:tfm + GOC:tfm MP:0004366 @@ -73126,7 +73367,7 @@ radial glial cells acting as neural progenitors throughout life. A polarized cell that is juxtaposed to fibrocytes in the underlying spiral ligament. This cell type secretes potassium ions derived from fibrocytes through gap junctions. - GOC:tfm + GOC:tfm MP:0004365 @@ -73176,7 +73417,7 @@ radial glial cells acting as neural progenitors throughout life. A cell located in the heart, including both muscle and non muscle cells. - GOC:tfm + GOC:tfm @@ -73197,7 +73438,7 @@ radial glial cells acting as neural progenitors throughout life. A fetal and neonatal heart cell that undergoes proliferation and is not yet terminally differentiated into a binucleate or a multinucleate cardiac myocyte. - GOC:tfm + GOC:tfm MP:0008788 @@ -73253,7 +73494,7 @@ radial glial cells acting as neural progenitors throughout life. A T cell that is located in the intestinal epithelium and is capable of a mucosal immune response. - GOC:tfm + GOC:tfm MP:0008894 @@ -73274,7 +73515,7 @@ radial glial cells acting as neural progenitors throughout life. A trophoblast giant cell derived from the mural trophectoderm. - GOC:tfm + GOC:tfm PMCID:PMC85124 @@ -73294,7 +73535,7 @@ radial glial cells acting as neural progenitors throughout life. A trophoblast giant cell that is derived from ectoplacental cone and, later in gestation, the spongiotrophoblast. - GOC:tfm + GOC:tfm PMCID:PMC85124 @@ -73314,7 +73555,7 @@ radial glial cells acting as neural progenitors throughout life. A trophoblast cell that arises in the junctional zone (basal plate) of the placenta. - GOC:tfm + GOC:tfm MP:0008959 @@ -73335,7 +73576,7 @@ radial glial cells acting as neural progenitors throughout life. A P/D1 enteroendocrine cell that is Grimelius positive and stores bombesin-like polypeptide. FMA:63418 - GOC:tfm + GOC:tfm @@ -73356,7 +73597,7 @@ radial glial cells acting as neural progenitors throughout life. A P/D1 enteroendocrine cell that is argyrophilic and stores vasoactive intestinal polypeptide. FMA:63207 - GOC:tfm + GOC:tfm @@ -73379,7 +73620,7 @@ radial glial cells acting as neural progenitors throughout life. An enteroendocrine cell of the small intestine that secretes motilin. - GOC:tfm + GOC:tfm PMID:15153415 @@ -73419,7 +73660,7 @@ radial glial cells acting as neural progenitors throughout life. A cell of the adventitial layer of ductal structures such as the uterer, defent duct, biliary duct, etc - GOC:tfm + GOC:tfm @@ -73462,7 +73703,7 @@ radial glial cells acting as neural progenitors throughout life. A smooth muscle cell of the intestine. - GOC:tfm + GOC:tfm @@ -73545,7 +73786,7 @@ radial glial cells acting as neural progenitors throughout life. A CD11b-positive dendritic cell that is CD11b-high, CD45-positive, MHC-II-positive and CD103-negative. - GOC:tfm + GOC:tfm http:http://www.immgen.org/index_content.html @@ -73624,7 +73865,7 @@ radial glial cells acting as neural progenitors throughout life. A CD11b-positive dendritic cell that is CD11b-low, CD45-positive, MHC-II-high and CD103-positive that is located in the liver. - GOC:tfm + GOC:tfm http:http://www.immgen.org/index_content.html @@ -73697,7 +73938,7 @@ radial glial cells acting as neural progenitors throughout life. A dermal dendritic cell isolated from skin draining lymph nodes that is langerin-positive, MHC-II-positive, and CD4-negative and CD8a-negative. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -73780,7 +74021,7 @@ radial glial cells acting as neural progenitors throughout life. A dermal dendritic cell isolated from skin draining lymph nodes that is langerin-negative, MHC-II-positive, and CD4-negative and CD8a-negative. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -73829,7 +74070,7 @@ radial glial cells acting as neural progenitors throughout life. A langerin-positive lymph node dendritic cell that is CD103-positive and CD11b-low. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -73883,7 +74124,7 @@ radial glial cells acting as neural progenitors throughout life. A langerin-positive lymph node dendritic cell that is CD103-negative and CD11b-high. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -73927,7 +74168,7 @@ radial glial cells acting as neural progenitors throughout life. A langerin-negative lymph node dendritic cell that is CD103-negative and CD11b-low. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -73971,7 +74212,7 @@ radial glial cells acting as neural progenitors throughout life. A langerin-negative lymph node dendritic cell that is CD103-negative and CD11b-high. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -73992,7 +74233,7 @@ radial glial cells acting as neural progenitors throughout life. A CD8alpha alpha positive gamma-delta intraepithelial T cell that expresses a TCR encoded in part by the Vgamma5 gene segment. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -74013,7 +74254,7 @@ radial glial cells acting as neural progenitors throughout life. A CD8alpha alpha positive gamma-delta intraepithelial T cell that does not express a TCR partially encoded by the Vgamma5 gene segment. - GOC:tfm + GOC:tfm http://www.immgen.org/index_content.html @@ -74037,7 +74278,7 @@ radial glial cells acting as neural progenitors throughout life. An interrenal chromaffin cell found in teleosts that contain heterogeneous vesicles with electron-dense granules located asymmetrically within the vesicular membrane. GOC:MH - GOC:tfm + GOC:tfm PMID:12668625 @@ -74058,7 +74299,7 @@ radial glial cells acting as neural progenitors throughout life. A chromaffin cell interspersed among the interrenal epithelial layer of the anterior kidney of teloest fish. GOC:MH - GOC:tfm + GOC:tfm PMID:12668625 @@ -74082,7 +74323,7 @@ radial glial cells acting as neural progenitors throughout life. An interrenal chromaffin cell found in teleosts that contain small, homogeneous electron-lucent granules that are separated from the vesicular membrane by a visible halo. GOC:MH - GOC:tfm + GOC:tfm PMID:12668625 @@ -74121,7 +74362,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell of the kidney. - GOC:tfm + GOC:tfm KUPO:SJ @@ -74142,7 +74383,7 @@ radial glial cells acting as neural progenitors throughout life. An interrenal epithelial kidney cell is an epithelial cell found in the anterior kidney of teleosts fish. This cell type is arranged in layers around the posterior cardinal vein and contains many mitochondria with tubulovesicular cristae. Interrenal chromaffin cells are interspersed among the tissue layer created by this cell type. GOC:mh - GOC:tfm + GOC:tfm PMID:12668625 @@ -74164,7 +74405,7 @@ radial glial cells acting as neural progenitors throughout life. An insect excretory cell that regulates haemolymph composition by filtration and filtrate endocytosis. - GOC:tfm + GOC:tfm PMID:19783135 @@ -74208,7 +74449,7 @@ radial glial cells acting as neural progenitors throughout life. A fat cell that is part of subcutaneous adipose tissue. - GOC:tfm + GOC:tfm @@ -74233,7 +74474,7 @@ radial glial cells acting as neural progenitors throughout life. A renal filtration cell is a specialized cell of the renal system that filter fluids by charge, size or both. - GOC:tfm + GOC:tfm @@ -74269,7 +74510,7 @@ radial glial cells acting as neural progenitors throughout life. A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains "feet" that interdigitate with the "feet" of other glomerular epithelial cells in the mesonephros - GOC:tfm + GOC:tfm @@ -74288,7 +74529,7 @@ radial glial cells acting as neural progenitors throughout life. A disseminated nephrocyte is a nephrocyte that filters hemolymph and is found at scattered locations in the fat body or other tissues. - GOC:tfm + GOC:tfm PMID:19783135 @@ -74325,7 +74566,7 @@ radial glial cells acting as neural progenitors throughout life. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains "feet" that interdigitate with the "feet" of other glomerular epithelial cells in the metanephros. - GOC:tfm + GOC:tfm @@ -74828,73 +75069,73 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell of the cervix. - GOC:tfm + GOC:tfm cervical canal epithelial cell - GOC:tfm + GOC:tfm cervical canal of uterus epithelial cell - GOC:tfm + GOC:tfm cervix epithelial cell - GOC:tfm + GOC:tfm cervix of uterus epithelial cell - GOC:tfm + GOC:tfm epithelial cell of cervical canal - GOC:tfm + GOC:tfm epithelial cell of cervical canal of uterus - GOC:tfm + GOC:tfm epithelial cell of cervix of uterus - GOC:tfm + GOC:tfm epithelial cell of neck of uterus - GOC:tfm + GOC:tfm epithelial cell of uterine cervix - GOC:tfm + GOC:tfm neck of uterus epithelial cell - GOC:tfm + GOC:tfm uterine cervix epithelial cell - GOC:tfm + GOC:tfm @@ -74944,7 +75185,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell that is part of the amnion. - GOC:tfm + GOC:tfm @@ -74981,7 +75222,7 @@ radial glial cells acting as neural progenitors throughout life. A mesenchymal stem cell of the amnion membrane. - GOC:tfm + GOC:tfm PMID:20446274 PMID:21339039 @@ -75026,7 +75267,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell of the intrahepatic portion of the bile duct. These cells are flattened or cuboidal in shape, and have a small nuclear-to-cytoplasmic ratio relative to large/extrahepatic cholangiocytes. - GOC:tfm + GOC:tfm PMID:23720296 @@ -75070,7 +75311,7 @@ radial glial cells acting as neural progenitors throughout life. A smooth muscle cell of the aorta. - GOC:tfm + GOC:tfm @@ -75101,7 +75342,7 @@ radial glial cells acting as neural progenitors throughout life. A mesenchymal stem cell that is part of the bone marrow. - GOC:tfm + GOC:tfm @@ -75137,7 +75378,7 @@ radial glial cells acting as neural progenitors throughout life. A mesenchymal stem cell of the chorionic membrane. - GOC:tfm + GOC:tfm @@ -75184,7 +75425,7 @@ radial glial cells acting as neural progenitors throughout life. An endothelial cell that is part of the vein. - GOC:tfm + GOC:tfm @@ -75205,7 +75446,7 @@ radial glial cells acting as neural progenitors throughout life. An arterial endothelial cell that is part of the aorta endothelium. - GOC:tfm + GOC:tfm @@ -75247,7 +75488,7 @@ radial glial cells acting as neural progenitors throughout life. An endothelial cell that is part of the thoracic endothelium. - GOC:tfm + GOC:tfm @@ -75268,7 +75509,7 @@ radial glial cells acting as neural progenitors throughout life. An endothelial progenitor cell that participates in angiogenesis during development. - GOC:tfm + GOC:tfm @@ -75310,7 +75551,7 @@ radial glial cells acting as neural progenitors throughout life. A fibroblast of the aortic adventitia. - GOC:tfm + GOC:tfm @@ -75360,7 +75601,7 @@ radial glial cells acting as neural progenitors throughout life. A fibroblast that is part of the heart. - GOC:tfm + GOC:tfm @@ -75403,7 +75644,7 @@ radial glial cells acting as neural progenitors throughout life. A fibroblast that is part of the choroid plexus. - GOC:tfm + GOC:tfm @@ -75439,7 +75680,7 @@ radial glial cells acting as neural progenitors throughout life. A fibroblast that is part of the conjuctiva of the eye. - GOC:tfm + GOC:tfm @@ -75553,7 +75794,7 @@ radial glial cells acting as neural progenitors throughout life. A fibroblast that is part of lung. - GOC:tfm + GOC:tfm @@ -75595,7 +75836,7 @@ radial glial cells acting as neural progenitors throughout life. A fibroblast of the lymphatic system. - GOC:tfm + GOC:tfm @@ -75637,7 +75878,7 @@ radial glial cells acting as neural progenitors throughout life. A fibroblast that is part of the mammary gland. - GOC:tfm + GOC:tfm @@ -75679,7 +75920,7 @@ radial glial cells acting as neural progenitors throughout life. A fibroblast of the periodontium. - GOC:tfm + GOC:tfm @@ -75721,7 +75962,7 @@ radial glial cells acting as neural progenitors throughout life. A fibroblast of pulmonary artery. - GOC:tfm + GOC:tfm @@ -75746,7 +75987,7 @@ radial glial cells acting as neural progenitors throughout life. A fibroblast that is part of villous mesenchyme. - GOC:tfm + GOC:tfm @@ -75788,7 +76029,7 @@ radial glial cells acting as neural progenitors throughout life. An animal cell that is part of a hair follicle. - GOC:tfm + GOC:tfm @@ -75831,7 +76072,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell that resides in the inner root sheath of the hair follicle. - GOC:tfm + GOC:tfm @@ -75874,7 +76115,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell that is part of the outer root sheath. - GOC:tfm + GOC:tfm @@ -75918,7 +76159,7 @@ radial glial cells acting as neural progenitors throughout life. An epidermal cell that is part of the germinal matrix. - GOC:tfm + GOC:tfm @@ -75960,7 +76201,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell of the intestine. - GOC:tfm + GOC:tfm @@ -75996,7 +76237,7 @@ radial glial cells acting as neural progenitors throughout life. A connective tissue cell of the nucleus pulposus cell of intervertebral disc. - GOC:tfm + GOC:tfm @@ -76039,7 +76280,7 @@ radial glial cells acting as neural progenitors throughout life. A pigment cell located in the epithelium of the iris. - GOC:tfm + GOC:tfm @@ -76058,7 +76299,7 @@ radial glial cells acting as neural progenitors throughout life. A melanocyte that appears darker due to content or amount of melanin granules. - GOC:tfm + GOC:tfm @@ -76077,7 +76318,7 @@ radial glial cells acting as neural progenitors throughout life. A melanocyte that appears lighter in color. - GOC:tfm + GOC:tfm @@ -76096,7 +76337,7 @@ radial glial cells acting as neural progenitors throughout life. A mesenchymal stem cell that is part of Wharton's jelly. - GOC:tfm + GOC:tfm @@ -76133,7 +76374,7 @@ radial glial cells acting as neural progenitors throughout life. A mesenchymal stem cell of the umbilical cord. - GOC:tfm + GOC:tfm @@ -76169,7 +76410,7 @@ radial glial cells acting as neural progenitors throughout life. A mesenchymal stem cell of adipose tissue. - GOC:tfm + GOC:tfm @@ -76206,7 +76447,7 @@ radial glial cells acting as neural progenitors throughout life. A mesenchymal stem cell of liver. - GOC:tfm + GOC:tfm @@ -76249,7 +76490,7 @@ radial glial cells acting as neural progenitors throughout life. A mesenchymal stem cell of the vertebrae. - GOC:tfm + GOC:tfm @@ -76287,7 +76528,7 @@ radial glial cells acting as neural progenitors throughout life. A glial cell that ensheathes axons of neuron in the peripheral nervous system and are necessary for their maintainance and function. - GOC:tfm + GOC:tfm @@ -76329,7 +76570,7 @@ radial glial cells acting as neural progenitors throughout life. A stromal cell of the pancreas. - GOC:tfm + GOC:tfm @@ -76372,7 +76613,7 @@ radial glial cells acting as neural progenitors throughout life. A pericyte of the central nervous system. - GOC:tfm + GOC:tfm @@ -76460,7 +76701,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell of the placenta. - GOC:tfm + GOC:tfm @@ -76502,7 +76743,7 @@ radial glial cells acting as neural progenitors throughout life. A preadipocyte found in mesenteric tissue. - GOC:tfm + GOC:tfm @@ -76574,7 +76815,7 @@ radial glial cells acting as neural progenitors throughout life. A preadipocyte that is part of the breast. - GOC:tfm + GOC:tfm @@ -76628,7 +76869,7 @@ radial glial cells acting as neural progenitors throughout life. A preadipocyte that is part of visceral tissue. - GOC:tfm + GOC:tfm @@ -76670,7 +76911,7 @@ radial glial cells acting as neural progenitors throughout life. A preadipocyte that is part of subcutaneous tissue. - GOC:tfm + GOC:tfm @@ -76712,7 +76953,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell of the kidney cortex. - GOC:tfm + GOC:tfm @@ -76755,7 +76996,7 @@ radial glial cells acting as neural progenitors throughout life. A blood vessel endothelial cell that is part of the retina. - GOC:tfm + GOC:tfm @@ -76807,7 +77048,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell of the retinal pigmented epithelium. - GOC:tfm + GOC:tfm @@ -76843,7 +77084,7 @@ radial glial cells acting as neural progenitors throughout life. A smooth muscle cell of the umbilical vein. - GOC:tfm + GOC:tfm @@ -76879,7 +77120,7 @@ radial glial cells acting as neural progenitors throughout life. A smooth muscle cell of the bachiocephalic vasculature. - GOC:tfm + GOC:tfm @@ -76922,7 +77163,7 @@ radial glial cells acting as neural progenitors throughout life. A vascular associated smooth muscle cell of the brain vasculature. - GOC:tfm + GOC:tfm @@ -76959,7 +77200,7 @@ radial glial cells acting as neural progenitors throughout life. A smooth muscle of the pulmonary artery. - GOC:tfm + GOC:tfm @@ -76996,7 +77237,7 @@ radial glial cells acting as neural progenitors throughout life. A smooth muscle cell of the coronary artery. - GOC:tfm + GOC:tfm @@ -77032,7 +77273,7 @@ radial glial cells acting as neural progenitors throughout life. A smooth muscle of the internal thoracic artery. - GOC:tfm + GOC:tfm @@ -77068,7 +77309,7 @@ radial glial cells acting as neural progenitors throughout life. A smooth muscle cell of the umbilical artery. - GOC:tfm + GOC:tfm @@ -77104,7 +77345,7 @@ radial glial cells acting as neural progenitors throughout life. A smooth muscle cell of the subclavian artery. - GOC:tfm + GOC:tfm @@ -77140,7 +77381,7 @@ radial glial cells acting as neural progenitors throughout life. Smooth muscle cell of the carotid artery. - GOC:tfm + GOC:tfm @@ -77250,7 +77491,7 @@ radial glial cells acting as neural progenitors throughout life. A smooth muscle cell of the esophagus. - GOC:tfm + GOC:tfm @@ -77286,7 +77527,7 @@ radial glial cells acting as neural progenitors throughout life. A smooth muscle cell of the trachea. - GOC:tfm + GOC:tfm @@ -77328,7 +77569,7 @@ radial glial cells acting as neural progenitors throughout life. A smooth muscle cell of the uterus. - GOC:tfm + GOC:tfm @@ -77407,7 +77648,7 @@ radial glial cells acting as neural progenitors throughout life. An astrocyte of the cerebellum. - GOC:tfm + GOC:tfm @@ -77462,7 +77703,7 @@ radial glial cells acting as neural progenitors throughout life. An astrocyte of the cerebral cortex. - GOC:tfm + GOC:tfm @@ -77504,7 +77745,7 @@ radial glial cells acting as neural progenitors throughout life. An astrocyte of the spinal cord. - GOC:tfm + GOC:tfm @@ -77523,7 +77764,7 @@ radial glial cells acting as neural progenitors throughout life. A neural crest cell that gives rise to cells of the enteric nervous system. - GOC:tfm + GOC:tfm @@ -77565,7 +77806,7 @@ radial glial cells acting as neural progenitors throughout life. A neuron of the hippocampus. - GOC:tfm + GOC:tfm @@ -77599,7 +77840,7 @@ radial glial cells acting as neural progenitors throughout life. A CNS neuron of the cerebral cortex. - GOC:tfm + GOC:tfm @@ -77642,7 +77883,7 @@ radial glial cells acting as neural progenitors throughout life. A neuron of the raphe nuclei. - GOC:tfm + GOC:tfm @@ -77685,7 +77926,7 @@ radial glial cells acting as neural progenitors throughout life. A CNS neuron of the dorsal spinal cord. - GOC:tfm + GOC:tfm @@ -77728,7 +77969,7 @@ radial glial cells acting as neural progenitors throughout life. A neuron of the ventral spinal cord. - GOC:tfm + GOC:tfm @@ -77764,7 +78005,7 @@ radial glial cells acting as neural progenitors throughout life. A neuron of the striatum. - GOC:tfm + GOC:tfm @@ -77807,7 +78048,7 @@ radial glial cells acting as neural progenitors throughout life. A neuron of the substantia nigra. - GOC:tfm + GOC:tfm @@ -77851,7 +78092,7 @@ radial glial cells acting as neural progenitors throughout life. A fat cell that is part of omentum tissue. - GOC:tfm + GOC:tfm @@ -77894,7 +78135,7 @@ radial glial cells acting as neural progenitors throughout life. A fat cell of perirenal fat tissue. - GOC:tfm + GOC:tfm @@ -77940,7 +78181,7 @@ radial glial cells acting as neural progenitors throughout life. A fat cell that is part of the breast. - GOC:tfm + GOC:tfm @@ -77977,7 +78218,7 @@ radial glial cells acting as neural progenitors throughout life. An endothelial cell of the umbilical vein. - GOC:tfm + GOC:tfm @@ -77997,7 +78238,7 @@ radial glial cells acting as neural progenitors throughout life. An adult angioblastic cell released from the bone marrow, capable of blood circulation and participation in angiogenesis by differentiating into blood vessel endothelial cells. Their existence is controversial. - GOC:tfm + GOC:tfm PMID:20807818 PMID:9020076 @@ -78043,7 +78284,7 @@ radial glial cells acting as neural progenitors throughout life. A fibroblast of skin. - GOC:tfm + GOC:tfm @@ -78115,7 +78356,7 @@ radial glial cells acting as neural progenitors throughout life. A stromal cell of the prostate. - GOC:tfm + GOC:tfm @@ -78152,7 +78393,7 @@ radial glial cells acting as neural progenitors throughout life. An acinar cell of salivary gland. - GOC:tfm + GOC:tfm @@ -78183,7 +78424,7 @@ radial glial cells acting as neural progenitors throughout life. A paneth cell of the appendix. - GOC:tfm + GOC:tfm @@ -78226,7 +78467,7 @@ radial glial cells acting as neural progenitors throughout life. A cell of the seminiferous tubule epithelium. - GOC:tfm + GOC:tfm @@ -78411,7 +78652,7 @@ radial glial cells acting as neural progenitors throughout life. A spore formed from bacteria in the order Actinomycetales. GO:0034304 - GOC:tfm + GOC:tfm @@ -78503,7 +78744,7 @@ radial glial cells acting as neural progenitors throughout life. A basal cell in the respiratory tract. - GOC:tfm + GOC:tfm PMID:20699479 @@ -78540,7 +78781,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell of the anal column. - GOC:tfm + GOC:tfm @@ -78560,7 +78801,7 @@ radial glial cells acting as neural progenitors throughout life. A nonkeratinized epithelial cell of the anal canal. - GOC:tfm + GOC:tfm @@ -78581,7 +78822,7 @@ radial glial cells acting as neural progenitors throughout life. A nonkeratinized cell epithleial cell of the inferior part of the anal canal. - GOC:tfm + GOC:tfm @@ -78612,7 +78853,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell of the anal canal that is keratinized. This cell type is found towards the lower, rectal end of the anal canal. - GOC:tfm + GOC:tfm @@ -78649,7 +78890,7 @@ radial glial cells acting as neural progenitors throughout life. A respiratory stem cell found at the junction of the terminal (conductive) bronchiole and the respiratory bronchiole. This cell types gives rise to alveolar cell types and club cells in response to lung injury. This cell type expresses markers Scgb1a1 and Sftpc. - GOC:tfm + GOC:tfm PMID:15960971 @@ -78671,7 +78912,7 @@ radial glial cells acting as neural progenitors throughout life. An amniotic stem cell is a mesenchymalstem cell extracted from amniotic fluid. Amniotic stem cells are able to differentiate into various tissue type such as skin, cartilage, cardiac tissue, nerves, muscle, and bone - GOC:tfm + GOC:tfm PMID:20942606 @@ -78691,7 +78932,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial fate stem cell derived form the amnion membrane. - GOC:tfm + GOC:tfm PMID:20446274 @@ -78712,7 +78953,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell of the esophageal gland proper. - GOC:tfm + GOC:tfm @@ -78732,7 +78973,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell of the esophageal cardiac gland that occurs both in the proximal and distal esophagus, within the lamina propia. - GOC:tfm + GOC:tfm http://web.mac.com/wjkrause/iWeb/Histology/Blog/E3FA5916-1AA9-4885-B579-5051838D98CB.html @@ -78753,7 +78994,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell of stratum corneum of esophageal epithelium that lacks keratin. - GOC:tfm + GOC:tfm @@ -78773,7 +79014,7 @@ radial glial cells acting as neural progenitors throughout life. An endothelial cell of viscerocranial mucosa that is part of the tympanic region of the viscerocranial mucosa. - GOC:tfm + GOC:tfm @@ -78793,7 +79034,7 @@ radial glial cells acting as neural progenitors throughout life. An endocranial viscerocranial mucosa cell that is part of viscerocranial mucosa. - GOC:tfm + GOC:tfm @@ -78813,7 +79054,7 @@ radial glial cells acting as neural progenitors throughout life. An ecto-epithelial cell of the buccal region of the viscerocranial mucosa. - GOC:tfm + GOC:tfm @@ -78833,7 +79074,7 @@ radial glial cells acting as neural progenitors throughout life. An ecto-epithelial cell of the palatal region of the viscerocranial mucosa. - GOC:tfm + GOC:tfm @@ -78853,7 +79094,7 @@ radial glial cells acting as neural progenitors throughout life. An ecto-epithelial cell of the nasal region of the viscerocranial mucosa. - GOC:tfm + GOC:tfm @@ -78873,7 +79114,7 @@ radial glial cells acting as neural progenitors throughout life. An ecto-epithelial cell of the gingival region of the viscerocranial mucosa. - GOC:tfm + GOC:tfm @@ -78893,7 +79134,7 @@ radial glial cells acting as neural progenitors throughout life. An ecto-epithelial cell of the paranasal region of the viscerocranial mucosa. - GOC:tfm + GOC:tfm @@ -78914,7 +79155,7 @@ radial glial cells acting as neural progenitors throughout life. An endothelial cell that is part of the venous sinus of spleen. This endothelial cell has an elongated, spindle-shaped, flattened morphology that is parallel to long axis of sinus. This cell type rests on a basement membrane interrupted by numerous narrow slits. - GOC:tfm + GOC:tfm @@ -78944,7 +79185,7 @@ radial glial cells acting as neural progenitors throughout life. A venule endothelial cell that is cubodial, expresses leukocyte-specific receptors, and allows for passage of lymphocytes into bloodstream. - GOC:tfm + GOC:tfm PMID:20726857 @@ -78965,7 +79206,7 @@ radial glial cells acting as neural progenitors throughout life. A endothelial cell of the venule that is squamous shaped. This is in contrast to the cubodial shape of high endothelial venule cells. - GOC:tfm + GOC:tfm @@ -78985,7 +79226,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell of stratum corneum of esophageal epithelium. - GOC:tfm + GOC:tfm @@ -79005,7 +79246,7 @@ radial glial cells acting as neural progenitors throughout life. An epithelial cell of stratum spinosum of esophageal epithelium. - GOC:tfm + GOC:tfm @@ -79042,7 +79283,7 @@ radial glial cells acting as neural progenitors throughout life. A glandular epithelial cell of the endometrium. - GOC:tfm + GOC:tfm @@ -79086,7 +79327,7 @@ radial glial cells acting as neural progenitors throughout life. A glandular epithelial cell of the esophagus. - GOC:tfm + GOC:tfm @@ -79124,7 +79365,7 @@ radial glial cells acting as neural progenitors throughout life. A glandular epithelial cell of the large intestine. - GOC:tfm + GOC:tfm @@ -79163,7 +79404,7 @@ radial glial cells acting as neural progenitors throughout life. A glandular epithelial cell that is part of the stomach. - GOC:tfm + GOC:tfm @@ -79184,7 +79425,7 @@ radial glial cells acting as neural progenitors throughout life. A luminal epithelial cell of mammary gland located in acinus of structure. - GOC:tfm + GOC:tfm @@ -79204,7 +79445,7 @@ radial glial cells acting as neural progenitors throughout life. A luminal cell of terminal ducts, i.e.e the terminal branch of a lactiferous duct which alveolar cells drain into. - GOC:tfm + GOC:tfm @@ -79225,7 +79466,7 @@ radial glial cells acting as neural progenitors throughout life. A luminal epithelial cell of the lactiferous duct. This cuboidal epithelial cell expresses keratin-18 and is estrogen-receptor alpha positive. - GOC:tfm + GOC:tfm PMID:19022771 @@ -79269,7 +79510,7 @@ radial glial cells acting as neural progenitors throughout life. A myocardial endocrine cell that is part of the atrium. - GOC:tfm + GOC:tfm @@ -79291,7 +79532,7 @@ radial glial cells acting as neural progenitors throughout life. A stem cell that can give rise to multiple cell types (i.e. smooth muscle, endothelial) in the developing heart. - GOC:tfm + GOC:tfm PMID:19745164 @@ -79330,7 +79571,7 @@ radial glial cells acting as neural progenitors throughout life. A fibrocyte of the cochlea that has specialized structural and molecular adaptions. - GOC:tfm + GOC:tfm PMID:18353863 @@ -79352,7 +79593,7 @@ radial glial cells acting as neural progenitors throughout life. An otic fibrocyte that underlies the spiral prominence and is part of a mesenchymal gap junction network that regulates ionic homeostasis of the endolymph. - GOC:tfm + GOC:tfm PMID:18353863 @@ -79380,7 +79621,7 @@ radial glial cells acting as neural progenitors throughout life. An otic fibrocyte that resides above the stria vasularis and is part of a mesenchymal gap junction network that regulates ionic homeostasis of the endolymph. - GOC:tfm + GOC:tfm PMID:18353863 @@ -79402,7 +79643,7 @@ radial glial cells acting as neural progenitors throughout life. An otic fibrocyte that is lateral to the basilar membrane and anchoris it to the lateral wall. - GOC:tfm + GOC:tfm PMID:18353863 @@ -79430,7 +79671,7 @@ radial glial cells acting as neural progenitors throughout life. An otic fibrocyte that lines the otic capsule. - GOC:tfm + GOC:tfm PMID:18353863 @@ -79458,7 +79699,7 @@ radial glial cells acting as neural progenitors throughout life. An otic fibrocyte that underlies the stria vascularis and is part of a mesenchymal gap junction network that regulates ionic homeostasis of the endolymph. - GOC:tfm + GOC:tfm PMID:18353863 @@ -79484,7 +79725,7 @@ radial glial cells acting as neural progenitors throughout life. An endothelial stalk cell is a specialized endothelial cell that follows behind the tip cell of an angiogenic sprout. - GOC:tfm + GOC:tfm PMID:21521739 @@ -79510,7 +79751,7 @@ radial glial cells acting as neural progenitors throughout life. A multi-fate stem cell that can give rise to different retinal cell types including rod and cone cells. - GOC:tfm + GOC:tfm PMID:20959166 PMID:21148186 @@ -79548,7 +79789,7 @@ radial glial cells acting as neural progenitors throughout life. A skeletal muscle cell that is part of the tongue. - GOC:tfm + GOC:tfm PMID:18816858 @@ -79569,7 +79810,7 @@ radial glial cells acting as neural progenitors throughout life. A S. pombe mating type determined by the mat1-Mc and mat1-Mi on the mat1 locus. - GOC:tfm + GOC:tfm @@ -79588,7 +79829,7 @@ radial glial cells acting as neural progenitors throughout life. A S. pombe cell type determined by mat1-Pc and mat1-Pi on the mat1 locus. - GOC:tfm + GOC:tfm @@ -79614,7 +79855,7 @@ radial glial cells acting as neural progenitors throughout life. A neuroblast derived from a neural crest cell. - GOC:tfm + GOC:tfm PMID:17407019 @@ -79639,7 +79880,7 @@ radial glial cells acting as neural progenitors throughout life. A regulatory T cell that has not encountered antigen. - GOC:tfm + GOC:tfm @@ -79671,7 +79912,7 @@ radial glial cells acting as neural progenitors throughout life. A CD4-positive, CD25-positive alpha-beta regulatory T cell that has encountered antigen. - GOC:tfm + GOC:tfm PMID:21739668 @@ -79804,7 +80045,7 @@ radial glial cells acting as neural progenitors throughout life. A lymphocyte found in adipose tissue that lacks lineage markers of other lymphocytes but is capable of mediating TH2 cytokine responses. This cell type is found in fat associated lymphoid clusters, proliferates in response to IL2 and produce large amounts of TH2 cytokines such as IL5, IL6 and IL13 - GOC:tfm + GOC:tfm PMID:20023630 @@ -79842,7 +80083,7 @@ radial glial cells acting as neural progenitors throughout life. A PP cell found in intestine. - GOC:tfm + GOC:tfm PMID:2420136 PMID:728970 @@ -80242,7 +80483,7 @@ radial glial cells acting as neural progenitors throughout life. A non-sensory cell that extends from the basement membrane to the apical surface of the auditory epithelium and provides support for auditory hair cells. CL:CVS - GOC:tfm + GOC:tfm @@ -81302,7 +81543,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A transversely striated, synctial cell of skeletal muscle. It is formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. - GOC:tfm + GOC:tfm ISBN:0323052908 @@ -86565,7 +86806,7 @@ plexiform layer using GABA. A rod-like cell in the inner ear, having their heads joined and their bases on the basilar membrane widely separated so as to form a spiral tunnel known as the tunnel of Corti. - GOC:tfm + GOC:tfm PMID:12417662 @@ -86818,7 +87059,7 @@ plexiform layer using GABA. A smooth muscle cell that is part of the small intestine. - GOC:tfm + GOC:tfm @@ -86866,7 +87107,7 @@ plexiform layer using GABA. A smooth muscle cell that is part of the duodenum. - GOC:tfm + GOC:tfm @@ -86914,7 +87155,7 @@ plexiform layer using GABA. A smooth muscle cell that is part of the jejunum. - GOC:tfm + GOC:tfm @@ -86962,7 +87203,7 @@ plexiform layer using GABA. A smooth muscle cell that is part of the ileum. - GOC:tfm + GOC:tfm @@ -87010,7 +87251,7 @@ plexiform layer using GABA. A smooth muscle cell that is part of the large intestine. - GOC:tfm + GOC:tfm @@ -87052,7 +87293,7 @@ plexiform layer using GABA. A smooth muscle cell that is part of the colon. - GOC:tfm + GOC:tfm @@ -87095,7 +87336,7 @@ plexiform layer using GABA. A smooth muscle cell that is part of the cecum. - GOC:tfm + GOC:tfm @@ -87143,7 +87384,7 @@ plexiform layer using GABA. A smooth muscle cell that is part of the ascending colon. - GOC:tfm + GOC:tfm @@ -87191,7 +87432,7 @@ plexiform layer using GABA. A smooth muscle cell that is part of the transverse colon. - GOC:tfm + GOC:tfm @@ -87239,7 +87480,7 @@ plexiform layer using GABA. A smooth muscle cell that is part of the descending colon. - GOC:tfm + GOC:tfm @@ -87287,7 +87528,7 @@ plexiform layer using GABA. A smooth muscle cell that is part of the sigmoid colon. - GOC:tfm + GOC:tfm @@ -87330,7 +87571,7 @@ plexiform layer using GABA. A smooth muscle cell that is part of the rectum. - GOC:tfm + GOC:tfm @@ -87354,7 +87595,7 @@ plexiform layer using GABA. A muscle cell that is part of the anterior internodal tract. - GOC:tfm + GOC:tfm @@ -87372,7 +87613,7 @@ plexiform layer using GABA. A muscle cell that is part of the atrial branch of anterior internodal tract. - GOC:tfm + GOC:tfm @@ -87390,7 +87631,7 @@ plexiform layer using GABA. A muscle cell that is part of the atrial septal branch of anterior internodal tract. - GOC:tfm + GOC:tfm @@ -87408,7 +87649,7 @@ plexiform layer using GABA. A muscle cell that is part of the middle internodal tract. - GOC:tfm + GOC:tfm @@ -87426,7 +87667,7 @@ plexiform layer using GABA. A muscle cell that is part of the posterior internodal tract. - GOC:tfm + GOC:tfm @@ -87463,7 +87704,7 @@ plexiform layer using GABA. An epithelial cell that is part of the urethra. - GOC:tfm + GOC:tfm @@ -87506,7 +87747,7 @@ plexiform layer using GABA. A mesothelial cell that is part of the dura mater. - GOC:tfm + GOC:tfm @@ -87536,7 +87777,7 @@ plexiform layer using GABA. A fibroblast that is part of the connective tissue of prostate. - GOC:tfm + GOC:tfm @@ -87560,7 +87801,7 @@ plexiform layer using GABA. A fibroblast that is part of the outer membrane of prostatic capsule. - GOC:tfm + GOC:tfm @@ -87584,7 +87825,7 @@ plexiform layer using GABA. A fibroblast that is part of the subepithelial connective tissue of prostatic gland. - GOC:tfm + GOC:tfm @@ -87625,7 +87866,7 @@ plexiform layer using GABA. A fibroblast that is part of the papillary layer of dermis. - GOC:tfm + GOC:tfm @@ -87666,7 +87907,7 @@ plexiform layer using GABA. A fibroblast that is part of the areolar connective tissue. - GOC:tfm + GOC:tfm @@ -87690,7 +87931,7 @@ plexiform layer using GABA. A fibroblast that is part of the connective tissue of nonglandular part of prostate. - GOC:tfm + GOC:tfm @@ -87714,7 +87955,7 @@ plexiform layer using GABA. A fibroblast that is part of the connective tissue of glandular part of prostate. - GOC:tfm + GOC:tfm @@ -87756,7 +87997,7 @@ plexiform layer using GABA. A fibroblast that is part of the tunica adventitia of artery. - GOC:tfm + GOC:tfm @@ -87797,7 +88038,7 @@ plexiform layer using GABA. A fibroblast that is part of the dense regular elastic tissue. - GOC:tfm + GOC:tfm @@ -87833,7 +88074,7 @@ plexiform layer using GABA. A fibrocyte that is part of the adventitia of ureter. - GOC:tfm + GOC:tfm @@ -87860,7 +88101,7 @@ plexiform layer using GABA. A fat cell that is part of the epicardial fat. - GOC:tfm + GOC:tfm @@ -87909,7 +88150,7 @@ plexiform layer using GABA. A fat cell that is part of the epicardial fat of right ventricle. - GOC:tfm + GOC:tfm @@ -87958,7 +88199,7 @@ plexiform layer using GABA. A fat cell that is part of the epicardial fat of left ventricle. - GOC:tfm + GOC:tfm @@ -88001,7 +88242,7 @@ plexiform layer using GABA. A goblet cell that is part of the epithelium of bronchus. - GOC:tfm + GOC:tfm @@ -88044,7 +88285,7 @@ plexiform layer using GABA. A goblet cell that is part of the epithelium of stomach. - GOC:tfm + GOC:tfm @@ -88097,7 +88338,7 @@ plexiform layer using GABA. A goblet cell that is part of the epithelium of gastric cardiac gland. - GOC:tfm + GOC:tfm @@ -88134,7 +88375,7 @@ plexiform layer using GABA. A goblet cell that is part of the epithelium of principal gastric gland. - GOC:tfm + GOC:tfm @@ -88153,7 +88394,7 @@ plexiform layer using GABA. OBSOLETE: A goblet cell that is part of the epithelium of small intestine. - GOC:tfm + GOC:tfm @@ -88189,7 +88430,7 @@ plexiform layer using GABA. A goblet cell that is part of the epithelium of intestinal villus. - GOC:tfm + GOC:tfm @@ -88207,7 +88448,7 @@ plexiform layer using GABA. A goblet cell that is part of the epithelium of crypt of lieberkuhn of small intestine. - GOC:tfm + GOC:tfm @@ -88225,7 +88466,7 @@ plexiform layer using GABA. OBSOLETE: A goblet cell that is part of the epithelium proper of small intestine. - GOC:tfm + GOC:tfm @@ -88262,7 +88503,7 @@ plexiform layer using GABA. A goblet cell that is part of the epithelium of large intestine. - GOC:tfm + GOC:tfm @@ -88327,7 +88568,7 @@ plexiform layer using GABA. A goblet cell that is part of the epithelium of crypt of lieberkuhn of large intestine. - GOC:tfm + GOC:tfm @@ -88365,7 +88606,7 @@ plexiform layer using GABA. A goblet cell that is part of the epithelium of pancreatic duct. - GOC:tfm + GOC:tfm @@ -88418,7 +88659,7 @@ plexiform layer using GABA. A goblet cell that is part of the epithelium of pyloric gland. - GOC:tfm + GOC:tfm @@ -88449,7 +88690,7 @@ plexiform layer using GABA. A goblet cell that is part of the epithelium proper of duodenum. - GOC:tfm + GOC:tfm @@ -88495,7 +88736,7 @@ plexiform layer using GABA. A goblet cell that is part of the epithelium proper of jejunum. - GOC:tfm + GOC:tfm @@ -88541,7 +88782,7 @@ plexiform layer using GABA. A goblet cell that is part of the epithelium proper of ileum. - GOC:tfm + GOC:tfm @@ -88572,7 +88813,7 @@ plexiform layer using GABA. A goblet cell that is part of the epithelium proper of appendix. - GOC:tfm + GOC:tfm @@ -88590,7 +88831,7 @@ plexiform layer using GABA. OBSOLETE: A goblet cell that is part of the epithelium proper of large intestine. - GOC:tfm + GOC:tfm @@ -88627,7 +88868,7 @@ plexiform layer using GABA. A goblet cell that is part of the epithelium of trachea. - GOC:tfm + GOC:tfm @@ -88668,7 +88909,7 @@ plexiform layer using GABA. A serous secreting cell that is part of the epithelium of trachea. - GOC:tfm + GOC:tfm @@ -88703,7 +88944,7 @@ plexiform layer using GABA. A serous secreting cell that is part of the epithelium of bronchus. - GOC:tfm + GOC:tfm @@ -88738,7 +88979,7 @@ plexiform layer using GABA. A serous secreting cell that is part of the epithelium of terminal bronchiole. - GOC:tfm + GOC:tfm @@ -88774,7 +89015,7 @@ plexiform layer using GABA. A serous secreting cell that is part of the epithelium of bronchiole. - GOC:tfm + GOC:tfm @@ -88816,7 +89057,7 @@ plexiform layer using GABA. An enterocyte that is part of the epithelium of small intestine. - GOC:tfm + GOC:tfm @@ -88851,7 +89092,7 @@ plexiform layer using GABA. An enterocyte that is part of the epithelium of intestinal villus. - GOC:tfm + GOC:tfm @@ -88887,7 +89128,7 @@ plexiform layer using GABA. An enterocyte that is part of the epithelium of duodenal gland. - GOC:tfm + GOC:tfm @@ -88911,7 +89152,7 @@ plexiform layer using GABA. An enterocyte that is part of the epithelium of crypt of lieberkuhn of small intestine. - GOC:tfm + GOC:tfm @@ -88929,7 +89170,7 @@ plexiform layer using GABA. An enterocyte that is part of the epithelium proper of small intestine. - GOC:tfm + GOC:tfm @@ -88953,7 +89194,7 @@ plexiform layer using GABA. An enterocyte that is part of the epithelium proper of duodenum. - GOC:tfm + GOC:tfm @@ -88971,7 +89212,7 @@ plexiform layer using GABA. An enterocyte that is part of the epithelium proper of jejunum. - GOC:tfm + GOC:tfm @@ -88989,7 +89230,7 @@ plexiform layer using GABA. An enterocyte that is part of the epithelium proper of ileum. - GOC:tfm + GOC:tfm @@ -89025,7 +89266,7 @@ plexiform layer using GABA. A paneth cell that is part of the epithelium of small intestine. - GOC:tfm + GOC:tfm @@ -89043,7 +89284,7 @@ plexiform layer using GABA. A Paneth cell that is part of the epithelium proper of small intestine. - GOC:tfm + GOC:tfm @@ -89067,7 +89308,7 @@ plexiform layer using GABA. A Paneth cell that is part of the epithelium of crypt of lieberkuhn of small intestine. - GOC:tfm + GOC:tfm @@ -89088,7 +89329,7 @@ plexiform layer using GABA. MERGED DEFINITION: TARGET DEFINITION: A columnar cell of the colon that is part of the epithelium proper of large intestine. SOURCE DEFINITION: An enterocyte that is part of the epithelium proper of large intestine. - GOC:tfm + GOC:tfm @@ -89124,7 +89365,7 @@ plexiform layer using GABA. A columnar cell of the colon that is part of the colonic epithelium. - GOC:tfm + GOC:tfm @@ -89166,7 +89407,7 @@ plexiform layer using GABA. A basal cell that is part of the epithelium of trachea. - GOC:tfm + GOC:tfm @@ -89199,7 +89440,7 @@ plexiform layer using GABA. A basal cell found in the bronchus epithelium. - GOC:tfm + GOC:tfm @@ -89234,7 +89475,7 @@ plexiform layer using GABA. A basal cell that is part of the epithelium of terminal bronchiole. - GOC:tfm + GOC:tfm @@ -89269,7 +89510,7 @@ plexiform layer using GABA. A basal cell that is part of the epithelium of respiratory bronchiole. - GOC:tfm + GOC:tfm @@ -89305,7 +89546,7 @@ plexiform layer using GABA. A basal cell that is part of the epithelium of bronchiole. - GOC:tfm + GOC:tfm @@ -89347,7 +89588,7 @@ plexiform layer using GABA. A M cell that is part of the epithelium of small intestine. - GOC:tfm + GOC:tfm @@ -89382,7 +89623,7 @@ plexiform layer using GABA. A M cell that is part of the epithelium of intestinal villus. - GOC:tfm + GOC:tfm @@ -89400,7 +89641,7 @@ plexiform layer using GABA. A M cell that is part of the epithelium proper of small intestine. - GOC:tfm + GOC:tfm @@ -89435,7 +89676,7 @@ plexiform layer using GABA. A M cell that is part of the epithelium proper of duodenum. - GOC:tfm + GOC:tfm @@ -89470,7 +89711,7 @@ plexiform layer using GABA. A M cell that is part of the epithelium proper of jejunum. - GOC:tfm + GOC:tfm @@ -89505,7 +89746,7 @@ plexiform layer using GABA. A M cell that is part of the epithelium proper of ileum. - GOC:tfm + GOC:tfm @@ -89537,7 +89778,7 @@ plexiform layer using GABA. A M cell that is part of the epithelium proper of appendix. - GOC:tfm + GOC:tfm @@ -89567,7 +89808,7 @@ plexiform layer using GABA. A M cell that is part of the epithelium proper of large intestine. - GOC:tfm + GOC:tfm @@ -89609,7 +89850,7 @@ plexiform layer using GABA. A transitional myocyte that is part of the interatrial septum. - GOC:tfm + GOC:tfm @@ -89651,7 +89892,7 @@ plexiform layer using GABA. A transitional myocyte that is part of the interventricular septum. - GOC:tfm + GOC:tfm @@ -89669,7 +89910,7 @@ plexiform layer using GABA. A transitional myocyte that is part of the atrial branch of anterior internodal tract. - GOC:tfm + GOC:tfm @@ -89687,7 +89928,7 @@ plexiform layer using GABA. A transitional myocyte that is part of the anterior internodal tract. - GOC:tfm + GOC:tfm @@ -89705,7 +89946,7 @@ plexiform layer using GABA. A transitional myocyte that is part of the atrial septal branch of anterior internodal tract. - GOC:tfm + GOC:tfm @@ -89723,7 +89964,7 @@ plexiform layer using GABA. A transitional myocyte that is part of the middle internodal tract. - GOC:tfm + GOC:tfm @@ -89741,7 +89982,7 @@ plexiform layer using GABA. A transitional myocyte that is part of the posterior internodal tract. - GOC:tfm + GOC:tfm @@ -89759,7 +90000,7 @@ plexiform layer using GABA. A transitional myocyte that is part of the anterior division of left branch of atrioventricular bundle. - GOC:tfm + GOC:tfm @@ -89777,7 +90018,7 @@ plexiform layer using GABA. A transitional myocyte that is part of the septal division of left branch of atrioventricular bundle. - GOC:tfm + GOC:tfm @@ -89812,7 +90053,7 @@ plexiform layer using GABA. A transitional myocyte that is part of the left branch of atrioventricular bundle. - GOC:tfm + GOC:tfm @@ -89847,7 +90088,7 @@ plexiform layer using GABA. A transitional myocyte that is part of the right branch of atrioventricular bundle. - GOC:tfm + GOC:tfm @@ -89865,7 +90106,7 @@ plexiform layer using GABA. A transitional myocyte that is part of the atrial part of atrioventricular bundle. - GOC:tfm + GOC:tfm @@ -89883,7 +90124,7 @@ plexiform layer using GABA. A transitional myocyte that is part of the ventricular part of atrioventricular bundle. - GOC:tfm + GOC:tfm @@ -89901,7 +90142,7 @@ plexiform layer using GABA. A transitional myocyte that is part of the posterior division of left branch of atrioventricular bundle. - GOC:tfm + GOC:tfm @@ -89927,7 +90168,7 @@ plexiform layer using GABA. A myocardial endocrine cell that is part of the septal division of left branch of atrioventricular bundle. - GOC:tfm + GOC:tfm @@ -89969,7 +90210,7 @@ plexiform layer using GABA. A Purkinje myocyte that is part of the interventricular septum. - GOC:tfm + GOC:tfm @@ -90017,7 +90258,7 @@ plexiform layer using GABA. A Feyrter cell that is part of the epithelium of trachea. - GOC:tfm + GOC:tfm @@ -90054,7 +90295,7 @@ plexiform layer using GABA. A type I vestibular sensory cell that is part of the stato-acoustic epithelium. - GOC:tfm + GOC:tfm @@ -90091,7 +90332,7 @@ plexiform layer using GABA. A type I vestibular sensory cell that is part of the epithelium of macula of utricle of membranous labyrinth. - GOC:tfm + GOC:tfm @@ -90134,7 +90375,7 @@ plexiform layer using GABA. A type I vestibular sensory cell that is part of the epithelium of macula of saccule of membranous labyrinth. - GOC:tfm + GOC:tfm @@ -90171,7 +90412,7 @@ plexiform layer using GABA. A type I vestibular sensory cell that is part of the epithelium of crista of ampulla of semicircular duct of membranous labyrinth. - GOC:tfm + GOC:tfm @@ -90208,7 +90449,7 @@ plexiform layer using GABA. A type II vestibular sensory cell that is part of the stato-acoustic epithelium. - GOC:tfm + GOC:tfm @@ -90245,7 +90486,7 @@ plexiform layer using GABA. A type II vestibular sensory cell that is part of the epithelium of macula of utricle of membranous labyrinth. - GOC:tfm + GOC:tfm @@ -90288,7 +90529,7 @@ plexiform layer using GABA. A type II vestibular sensory cell that is part of the epithelium of macula of saccule of membranous labyrinth. - GOC:tfm + GOC:tfm @@ -90325,7 +90566,7 @@ plexiform layer using GABA. A type II vestibular sensory cell that is part of the epithelium of crista of ampulla of semicircular duct of membranous labyrinth. - GOC:tfm + GOC:tfm @@ -90368,7 +90609,7 @@ plexiform layer using GABA. A melanocyte that is part of the eyelid. - GOC:tfm + GOC:tfm @@ -90398,7 +90639,7 @@ plexiform layer using GABA. A myoepithelial cell that is part of the intralobular part of terminal lactiferous duct. - GOC:tfm + GOC:tfm @@ -90435,7 +90676,7 @@ plexiform layer using GABA. An endothelial cell that is part of the venous sinus of red pulp of spleen. - GOC:tfm + GOC:tfm @@ -90474,7 +90715,7 @@ plexiform layer using GABA. An endothelial cell that is part of the hepatic sinusoid. These cells possess flattened areas containing perforations about 0.1 micrometers in diameter, known as fenestrae. The fenestrae are arranged in groups known as sieve plates. - GOC:tfm + GOC:tfm PMID:3926620 @@ -90530,7 +90771,7 @@ plexiform layer using GABA. An epithelial cell that is part of the appendix. - GOC:tfm + GOC:tfm @@ -90584,7 +90825,7 @@ plexiform layer using GABA. A muscle cell that is part of the sinoatrial node. FMA:67102 - GOC:tfm + GOC:tfm @@ -90656,7 +90897,7 @@ plexiform layer using GABA. A muscle cell that is part of the atrioventricular node. FMA:67106 - GOC:tfm + GOC:tfm @@ -90728,7 +90969,7 @@ plexiform layer using GABA. An endothelial cell that is part of the small intestine Peyer's patch. - GOC:tfm + GOC:tfm @@ -90770,7 +91011,7 @@ plexiform layer using GABA. An endothelial cell that is part of the arteriole. - GOC:tfm + GOC:tfm @@ -90809,7 +91050,7 @@ plexiform layer using GABA. A blood vessel endothelial cell that is part of an arterial endothelium. - GOC:tfm + GOC:tfm @@ -90850,7 +91091,7 @@ plexiform layer using GABA. An endothelial cell that is part of the venule. - GOC:tfm + GOC:tfm @@ -90892,7 +91133,7 @@ plexiform layer using GABA. An epithelial cell that is part of the gallbladder. - GOC:tfm + GOC:tfm @@ -90930,7 +91171,7 @@ plexiform layer using GABA. A myoepithelial cell that is part of the mammary gland. - GOC:tfm + GOC:tfm @@ -90972,7 +91213,7 @@ plexiform layer using GABA. A myoepithelial cell that is part of the sweat gland. - GOC:tfm + GOC:tfm @@ -91009,7 +91250,7 @@ plexiform layer using GABA. A myoepithelial cell that is part of the mammary gland alveolus. - GOC:tfm + GOC:tfm @@ -91057,7 +91298,7 @@ plexiform layer using GABA. A myoepithelial cell that is part of the lactiferous duct. - GOC:tfm + GOC:tfm @@ -91075,7 +91316,7 @@ plexiform layer using GABA. A myoepithelial cell that is part of the terminal lactiferous duct. - GOC:tfm + GOC:tfm @@ -91111,7 +91352,7 @@ plexiform layer using GABA. A chromaffin cell that is part of the paraaortic body. - GOC:tfm + GOC:tfm @@ -91158,7 +91399,7 @@ plexiform layer using GABA. A chromaffin cell that is part of the paraganglion. - GOC:tfm + GOC:tfm @@ -91201,7 +91442,7 @@ plexiform layer using GABA. A chromaffin cell that is part of the adrenal gland. - GOC:tfm + GOC:tfm @@ -91239,7 +91480,7 @@ plexiform layer using GABA. A chromaffin cell that is part of the adrenal cortex. - GOC:tfm + GOC:tfm @@ -91281,7 +91522,7 @@ plexiform layer using GABA. A somatic stem cell that is part of the epidermis. - GOC:tfm + GOC:tfm @@ -91330,7 +91571,7 @@ plexiform layer using GABA. An epithelial cell that is part of the conjunctiva. - GOC:tfm + GOC:tfm @@ -91378,7 +91619,7 @@ plexiform layer using GABA. An epithelial cell that is part of the lacrimal canaliculus. - GOC:tfm + GOC:tfm @@ -91420,7 +91661,7 @@ plexiform layer using GABA. An epithelial cell that is part of the external acoustic meatus. - GOC:tfm + GOC:tfm @@ -91461,7 +91702,7 @@ plexiform layer using GABA. An epithelial cell that is part of the lacrimal duct. - GOC:tfm + GOC:tfm @@ -91496,7 +91737,7 @@ plexiform layer using GABA. An epithelial cell that is part of the lacrimal sac. - GOC:tfm + GOC:tfm @@ -91531,7 +91772,7 @@ plexiform layer using GABA. An epithelial cell that is part of the nasolacrimal duct. - GOC:tfm + GOC:tfm @@ -91549,7 +91790,7 @@ plexiform layer using GABA. An epithelial cell that is part of the wall of inferior part of anal canal. - GOC:tfm + GOC:tfm @@ -91568,7 +91809,7 @@ plexiform layer using GABA. An epithelial cell that is part of the viscerocranial mucosa. - GOC:tfm + GOC:tfm @@ -91611,7 +91852,7 @@ plexiform layer using GABA. An urothelial cell that is part of the trigone of urinary bladder. - GOC:tfm + GOC:tfm @@ -91659,7 +91900,7 @@ plexiform layer using GABA. A smooth muscle cell that is part of the ciliary body. - GOC:tfm + GOC:tfm @@ -91706,7 +91947,7 @@ plexiform layer using GABA. A mesothelial cell that is part of the anterior chamber of eyeball. - GOC:tfm + GOC:tfm @@ -91747,7 +91988,7 @@ plexiform layer using GABA. A myoepithelial cell that is part of the dilatator pupillae. - GOC:tfm + GOC:tfm @@ -91789,7 +92030,7 @@ plexiform layer using GABA. A basal cell that is part of the epithelium of esophagus. - GOC:tfm + GOC:tfm @@ -91831,7 +92072,7 @@ plexiform layer using GABA. An epithelial cell that is part of the sweat gland. - GOC:tfm + GOC:tfm @@ -91866,7 +92107,7 @@ plexiform layer using GABA. An epithelial cell that is part of the nephron. - GOC:tfm + GOC:tfm @@ -91904,7 +92145,7 @@ plexiform layer using GABA. An epithelial cell that is part of the glomerular capsule. - GOC:tfm + GOC:tfm @@ -91958,7 +92199,7 @@ plexiform layer using GABA. An epithelial cell that is part of the glomerular parietal epithelium. - GOC:tfm + GOC:tfm @@ -91999,7 +92240,7 @@ plexiform layer using GABA. An epithelial cell that is part of the intermediate tubule. - GOC:tfm + GOC:tfm @@ -92043,7 +92284,7 @@ plexiform layer using GABA. An epithelial cell that is part of the collecting duct of renal tubule. - GOC:tfm + GOC:tfm @@ -92084,7 +92325,7 @@ plexiform layer using GABA. A mesothelial cell that is part of the parietal peritoneum. - GOC:tfm + GOC:tfm @@ -92119,7 +92360,7 @@ plexiform layer using GABA. A mesothelial cell that is part of the visceral peritoneum. - GOC:tfm + GOC:tfm @@ -92162,7 +92403,7 @@ plexiform layer using GABA. A melanocyte that is part of the skin of body. - GOC:tfm + GOC:tfm @@ -92204,7 +92445,7 @@ plexiform layer using GABA. A chromaffin cell that is part of the ovary. - GOC:tfm + GOC:tfm @@ -92239,7 +92480,7 @@ plexiform layer using GABA. A chromaffin cell that is part of the right ovary. - GOC:tfm + GOC:tfm @@ -92274,7 +92515,7 @@ plexiform layer using GABA. A chromaffin cell that is part of the left ovary. - GOC:tfm + GOC:tfm @@ -92299,7 +92540,7 @@ plexiform layer using GABA. A myoepithelial cell that is part of the acinus of lactiferous gland. - GOC:tfm + GOC:tfm @@ -92323,7 +92564,7 @@ plexiform layer using GABA. A myoepithelial cell that is part of the main lactiferous duct. - GOC:tfm + GOC:tfm @@ -92341,7 +92582,7 @@ plexiform layer using GABA. A myoepithelial cell that is part of the primary lactiferous duct. - GOC:tfm + GOC:tfm @@ -92359,7 +92600,7 @@ plexiform layer using GABA. A myoepithelial cell that is part of the secondary lactiferous duct. - GOC:tfm + GOC:tfm @@ -92377,7 +92618,7 @@ plexiform layer using GABA. A myoepithelial cell that is part of the tertiary lactiferous duct. - GOC:tfm + GOC:tfm @@ -92395,7 +92636,7 @@ plexiform layer using GABA. A myoepithelial cell that is part of the quarternary lactiferous duct. - GOC:tfm + GOC:tfm @@ -92416,7 +92657,7 @@ plexiform layer using GABA. A nodal myocyte that is part of the sinoatrial node. - GOC:tfm + GOC:tfm @@ -92453,7 +92694,7 @@ plexiform layer using GABA. A transitional myocyte that is part of the sinoatrial node. - GOC:tfm + GOC:tfm @@ -92489,7 +92730,7 @@ plexiform layer using GABA. A Purkinje myocyte that is part of the atrioventricular node. - GOC:tfm + GOC:tfm @@ -92525,7 +92766,7 @@ plexiform layer using GABA. A transitional myocyte that is part of the internodal tract. - GOC:tfm + GOC:tfm @@ -92563,7 +92804,7 @@ plexiform layer using GABA. A transitional myocyte that is part of the atrioventricular bundle. - GOC:tfm + GOC:tfm @@ -92605,7 +92846,7 @@ plexiform layer using GABA. A myocardial endocrine cell that is part of the interventricular septum. - GOC:tfm + GOC:tfm @@ -92641,7 +92882,7 @@ plexiform layer using GABA. A Purkinje myocyte that is part of the internodal tract. - GOC:tfm + GOC:tfm @@ -92678,7 +92919,7 @@ plexiform layer using GABA. A Purkinje myocyte that is part of the atrioventricular bundle. - GOC:tfm + GOC:tfm @@ -92719,7 +92960,7 @@ plexiform layer using GABA. A basal cell that is part of the urothelium. - GOC:tfm + GOC:tfm @@ -92761,7 +93002,7 @@ plexiform layer using GABA. A smooth muscle cell that is part of the prostate gland. - GOC:tfm + GOC:tfm @@ -92835,7 +93076,7 @@ plexiform layer using GABA. An epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts. - GOC:tfm + GOC:tfm PMID:16550043 PMID:18356246 @@ -92879,7 +93120,7 @@ plexiform layer using GABA. A reticular cell that is part of the splenic cord. - GOC:tfm + GOC:tfm @@ -92921,7 +93162,7 @@ plexiform layer using GABA. A mesothelial cell that is part of the peritoneum. - GOC:tfm + GOC:tfm @@ -92969,7 +93210,7 @@ plexiform layer using GABA. A mesothelial cell that is part of the pleura. - GOC:tfm + GOC:tfm @@ -93010,7 +93251,7 @@ plexiform layer using GABA. A mesothelial cell that is part of the parietal pleura. - GOC:tfm + GOC:tfm @@ -93046,7 +93287,7 @@ plexiform layer using GABA. A mesothelial cell that is part of the visceral pleura. - GOC:tfm + GOC:tfm @@ -93084,7 +93325,7 @@ plexiform layer using GABA. An epithelial cell that is part of a nephron tubule. - GOC:tfm + GOC:tfm @@ -93117,7 +93358,7 @@ plexiform layer using GABA. A goblet cell that is part of the small intestine. - GOC:tfm + GOC:tfm @@ -96548,7 +96789,7 @@ plexiform layer using GABA. An epithelial cell of the exocrine pancreas. - GOC:tfm + GOC:tfm @@ -103636,7 +103877,14 @@ plexiform layer using GABA. + + + + + + + A glutamatergic neuron, with a soma found in the deeper portion of L5, that has long-range axonal projections including deep subcortical targets outside of the telencephalon and, in some cases, the spinal cord. While the L5 ET neuron projections are not limited to ET targets, they are clearly differentiated from the neuron subclasses whose projections are constrained to intratelencephalic (IT) targets. L5 ET neurons are generally the largest excitatory cortical neurons, typically having a thick apical dendrite with a prominent dendritic tuft in layer 1 and displaying burst-firing physiological characteristics. L5b neuron @@ -104471,7 +104719,7 @@ plexiform layer using GABA. A type of interneuron that has two clusters of dendritic branches that originate directly from the soma and extend in opposite directions and axons that form a plexus which spreads widely. Compared to bipolar neurons, bitufted neurons have branching that occur close to the soma. - PMID:18568015 + PMID:18568015 @@ -104970,7 +105218,7 @@ plexiform layer using GABA. Nucleus with two or more lobes connected by a thin filament that contains no internal chromatin. - GOC:tfm + GOC:tfm @@ -105026,7 +105274,7 @@ plexiform layer using GABA. Cytoplasm that exhibits molecular interaction for basic dyes under specific pH conditions. - GOC:tfm + GOC:tfm @@ -105045,7 +105293,7 @@ plexiform layer using GABA. Cytoplasm that exhibits affinity for both basic and acid stains under specific pH conditions. - GOC:tfm + GOC:tfm @@ -105081,7 +105329,7 @@ plexiform layer using GABA. A nucleus size quality which is relatively high compared to the amount of cytoplasm present in the same cell. - GOC:tfm + GOC:tfm @@ -105100,7 +105348,7 @@ plexiform layer using GABA. A concave nuclear shape where the nucleus is indented to more than half the distance to the farthest nuclear margin, but in no area is the chromatin condensed to a single filament. - GOC:tfm + GOC:tfm @@ -105136,7 +105384,7 @@ plexiform layer using GABA. A concave nucleus shape where the indentation is smaller than half of the distance to the farthest nuclear margin. - GOC:tfm + GOC:tfm @@ -105155,7 +105403,7 @@ plexiform layer using GABA. Heterochromatin that is arranged in a carthwheel pattern. - GOC:tfm + GOC:tfm @@ -126903,7 +127151,7 @@ plexiform layer using GABA. The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. - GOC:nln + GOC:nln ISBN:0198506732 @@ -130378,8 +130626,8 @@ plexiform layer using GABA. The appearance of type I interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. GOC:add - ISBN:0126896631 - PMID:15546383 + ISBN:0126896631 + PMID:15546383 PMID:16681834 @@ -130414,7 +130662,7 @@ plexiform layer using GABA. The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon. GOC:add GOC:mah - PMID:15546383 + PMID:15546383 @@ -130549,7 +130797,7 @@ plexiform layer using GABA. The appearance of any member of the interleukin-17 family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. GOC:mah - GOC:rv + GOC:rv Wikipedia:Interleukin_17 @@ -130836,7 +131084,7 @@ plexiform layer using GABA. Any process that modulates the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. GOC:add GOC:mah - PMID:15546383 + PMID:15546383 @@ -131422,7 +131670,7 @@ plexiform layer using GABA. Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. GOC:add GOC:mah - PMID:15546383 + PMID:15546383 @@ -132082,7 +132330,7 @@ plexiform layer using GABA. Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. GOC:add GOC:mah - PMID:15546383 + PMID:15546383 @@ -139006,7 +139254,7 @@ plexiform layer using GABA. The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte. - GOC:rk + GOC:rk PMID:14685684 @@ -140020,7 +140268,7 @@ plexiform layer using GABA. Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. - GO:jl + GO:jl @@ -140057,7 +140305,7 @@ plexiform layer using GABA. Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. - GO:jl + GO:jl @@ -140285,7 +140533,7 @@ plexiform layer using GABA. Any process evolved to enable an interaction with an organism of a different species. - GOC:cc + GOC:cc @@ -153491,7 +153739,7 @@ plexiform layer using GABA. The chemical reactions and pathways resulting in the formation of a nitric-oxide synthase, an enzyme which catalyzes the reaction L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+. - EC:1.14.13.39 + EC:1.14.13.39 GOC:ai @@ -159246,7 +159494,7 @@ plexiform layer using GABA. TNF superfamily production - GOC:rv + GOC:rv @@ -159861,7 +160109,7 @@ plexiform layer using GABA. The aggregation, arrangement and bonding together of a set of components to form an extracellular vesicular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Exosomes are defined by their size, which generally ranges from 30 nm to 100 nm. GOC:mah - GOC:tfm + GOC:tfm PMID:19442504 PMID:27462458 @@ -161125,7 +161373,7 @@ plexiform layer using GABA. Any process that activates or increases the frequency, rate or extent of inhibitory postsynaptic potential (IPSP). IPSP is a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential. GOC:BHF - GOC:sjp + GOC:sjp PMID:18550748 @@ -161146,7 +161394,7 @@ plexiform layer using GABA. Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure. - GOC:sjw + GOC:sjw PMID:7583672 @@ -161393,29 +161641,6 @@ plexiform layer using GABA. - - - - OBSOLETE. Nucleus with two or more lobes connected by a thin filament that contains no internal chromatin. Examples include the nuclei of mature basophils, eosinophils and neutrophils in mice and humans. - https://github.com/geneontology/go-ontology/issues/20764 - dos - 2013-10-22T18:31:36Z - cellular_component - GO:0098537 - This term was obsoleted because it does not correspond to a specific type of nucleus, it is a morphologically different nucleus present in certain cell types. - obsolete lobed nucleus - true - - - - - OBSOLETE. Nucleus with two or more lobes connected by a thin filament that contains no internal chromatin. Examples include the nuclei of mature basophils, eosinophils and neutrophils in mice and humans. - GOC:dos - GOC:tfm - - - - @@ -183857,13 +184082,14 @@ plexiform layer using GABA. GC_ID:1 ncbi_taxonomy all + NCBITaxon:1 root all - + @@ -183872,10 +184098,11 @@ plexiform layer using GABA. - + GC_ID:1 PMID:15371245 ncbi_taxonomy + NCBITaxon:10066 Muridae @@ -183885,31 +184112,32 @@ plexiform layer using GABA. - + GC_ID:1 Mus mice mouse ncbi_taxonomy + NCBITaxon:10088 Mus <genus> Mus - + mice - + mouse - + @@ -183918,7 +184146,7 @@ plexiform layer using GABA. - + NCBITaxon:85055 GC_ID:1 house mouse @@ -183933,19 +184161,19 @@ plexiform layer using GABA. house mouse - + mouse - + m - PRO:DAN + PRO:DAN @@ -183961,9 +184189,9 @@ plexiform layer using GABA. - GC_ID:1 ncbi_taxonomy + NCBITaxon:117570 Teleostomi @@ -183973,18 +184201,39 @@ plexiform layer using GABA. - NCBITaxon:40673 GC_ID:1 bony vertebrates ncbi_taxonomy + NCBITaxon:117571 Euteleostomi bony vertebrates - + + + + + + + + + + + NCBITaxon:27837 + GC_ID:1 + ncbi_taxonomy + Adenophorea + NCBITaxon:119089 + Chromadorea + + + + + Adenophorea + @@ -183993,9 +184242,9 @@ plexiform layer using GABA. - GC_ID:1 ncbi_taxonomy + NCBITaxon:1206794 Ecdysozoa @@ -184005,9 +184254,9 @@ plexiform layer using GABA. - GC_ID:1 ncbi_taxonomy + NCBITaxon:1206795 Lophotrochozoa @@ -184020,13 +184269,14 @@ plexiform layer using GABA. GC_ID:1 ncbi_taxonomy biota + NCBITaxon:131567 cellular organisms biota - + @@ -184035,9 +184285,9 @@ plexiform layer using GABA. - GC_ID:1 ncbi_taxonomy + NCBITaxon:1338369 Dipnotetrapodomorpha @@ -184047,7 +184297,7 @@ plexiform layer using GABA. - + GC_ID:1 PMID:11062127 PMID:9342353 @@ -184055,25 +184305,26 @@ plexiform layer using GABA. Eumycetozoa Zopf, 1884 Mycetozoa mycetozoans + NCBITaxon:142796 Eumycetozoa Eumycetozoa Zopf, 1884 - + Mycetozoa - + mycetozoans - + @@ -184082,19 +184333,19 @@ plexiform layer using GABA. - GC_ID:1 PMID:11743200 PMID:11791233 ncbi_taxonomy Boreotheria + NCBITaxon:1437010 Boreoeutheria Boreotheria - + @@ -184103,24 +184354,25 @@ plexiform layer using GABA. - + GC_ID:1 mice and others ncbi_taxonomy Sciurognathi + NCBITaxon:1963758 Myomorpha mice and others - + Sciurognathi - + @@ -184129,28 +184381,56 @@ plexiform layer using GABA. - + GC_ID:1 ncbi_taxonomy Homo/Pan/Gorilla group + NCBITaxon:207598 Homininae Homo/Pan/Gorilla group - + + + + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:2301116 + Rhabditina + + + + + + + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:2301119 + Rhabditomorpha + + + + - + GC_ID:1 ncbi_taxonomy + NCBITaxon:2605435 Evosea @@ -184160,9 +184440,9 @@ plexiform layer using GABA. - GC_ID:1 ncbi_taxonomy + NCBITaxon:2697495 Spiralia @@ -184173,7 +184453,7 @@ plexiform layer using GABA. - + GC_ID:1 PMID:23020233 PMID:30257078 @@ -184193,50 +184473,50 @@ plexiform layer using GABA. eucaryotes - + eukaryotes - + Eucarya - + Eucaryotae - + Eukarya - + Eukaryotae - + euk- - PRO:DAN + PRO:DAN eukaryotes - + @@ -184245,12 +184525,13 @@ plexiform layer using GABA. - + GC_ID:1 PMID:11214318 PMID:11214319 PMID:12878460 ncbi_taxonomy + NCBITaxon:314145 Laurasiatheria @@ -184260,13 +184541,14 @@ plexiform layer using GABA. - + GC_ID:1 PMID:11214319 PMID:12082125 PMID:12878460 PMID:15522813 ncbi_taxonomy + NCBITaxon:314146 Euarchontoglires @@ -184276,20 +184558,20 @@ plexiform layer using GABA. - GC_ID:1 PMID:11214319 PMID:12082125 PMID:15522813 Rodents and rabbits ncbi_taxonomy + NCBITaxon:314147 Glires Rodents and rabbits - + @@ -184298,17 +184580,18 @@ plexiform layer using GABA. - + GC_ID:1 ncbi_taxonomy Anthropoidea + NCBITaxon:314293 Simiiformes Anthropoidea - + @@ -184317,24 +184600,25 @@ plexiform layer using GABA. - + GC_ID:1 ape apes ncbi_taxonomy + NCBITaxon:314295 Hominoidea ape - + apes - + @@ -184343,17 +184627,17 @@ plexiform layer using GABA. - GC_ID:1 tetrapods ncbi_taxonomy + NCBITaxon:32523 Tetrapoda tetrapods - + @@ -184362,17 +184646,17 @@ plexiform layer using GABA. - GC_ID:1 amniotes ncbi_taxonomy + NCBITaxon:32524 Amniota amniotes - + @@ -184381,17 +184665,17 @@ plexiform layer using GABA. - GC_ID:1 Theria ncbi_taxonomy + NCBITaxon:32525 Theria <mammals> Theria - + @@ -184400,7 +184684,6 @@ plexiform layer using GABA. - GC_ID:1 ncbi_taxonomy Fungi/Metazoa group @@ -184412,13 +184695,13 @@ plexiform layer using GABA. Fungi/Metazoa group - + opisthokonts - + @@ -184427,7 +184710,7 @@ plexiform layer using GABA. - + GC_ID:1 metazoans multicellular animals @@ -184442,31 +184725,31 @@ plexiform layer using GABA. metazoans - + multicellular animals - + Animalia - + animals - + metazoan- - PRO:DAN + PRO:DAN @@ -184476,9 +184759,9 @@ plexiform layer using GABA. - GC_ID:1 ncbi_taxonomy + NCBITaxon:33213 Bilateria @@ -184488,9 +184771,9 @@ plexiform layer using GABA. - GC_ID:1 ncbi_taxonomy + NCBITaxon:33317 Protostomia @@ -184500,17 +184783,17 @@ plexiform layer using GABA. - GC_ID:1 deuterostomes ncbi_taxonomy + NCBITaxon:33511 Deuterostomia deuterostomes - + @@ -184519,24 +184802,25 @@ plexiform layer using GABA. - + GC_ID:1 carnivores ncbi_taxonomy carnivores + NCBITaxon:33554 Carnivora carnivores - + carnivores - + @@ -184545,11 +184829,11 @@ plexiform layer using GABA. - GC_ID:1 PMID:15019624 PMID:15371245 ncbi_taxonomy + NCBITaxon:337687 Muroidea @@ -184559,9 +184843,10 @@ plexiform layer using GABA. - + GC_ID:1 ncbi_taxonomy + NCBITaxon:338152 Felinae @@ -184571,9 +184856,10 @@ plexiform layer using GABA. - + GC_ID:1 ncbi_taxonomy + NCBITaxon:376913 Haplorrhini @@ -184583,9 +184869,10 @@ plexiform layer using GABA. - + GC_ID:1 ncbi_taxonomy + NCBITaxon:379583 Feliformia @@ -184595,10 +184882,11 @@ plexiform layer using GABA. - + NCBITaxon:109679 GC_ID:1 ncbi_taxonomy + NCBITaxon:39107 Murinae @@ -184608,7 +184896,7 @@ plexiform layer using GABA. - + GC_ID:1 mammal mammals @@ -184628,20 +184916,20 @@ plexiform layer using GABA. mammals - + mammal- - PRO:DAN + PRO:DAN mammals - + @@ -184650,7 +184938,7 @@ plexiform layer using GABA. - + GC_ID:1 PMID:11062127 PMID:12684019 @@ -184665,26 +184953,26 @@ plexiform layer using GABA. Mycota - + fungal- - PRO:DAN + PRO:DAN fungi - + fungi - + @@ -184693,23 +184981,49 @@ plexiform layer using GABA. - GC_ID:1 PMID:23020233 PMID:30257078 ncbi_taxonomy + NCBITaxon:554915 Amoebozoa + + + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:55879 + Rhabditoidea + + + + + + + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:55885 + Peloderinae + + + + - GC_ID:1 ncbi_taxonomy + NCBITaxon:6072 Eumetazoa @@ -184719,32 +185033,129 @@ plexiform layer using GABA. - + GC_ID:1 flatworm flatworms ncbi_taxonomy flatworms + NCBITaxon:6157 Platyhelminthes flatworm - + flatworms - + flatworms - + + + + + + + + + + + GC_ID:1 + nematode + nematodes + roundworm + roundworms + ncbi_taxonomy + Nemata + nematodes + NCBITaxon:6231 + Nematoda + + + + + nematode + + + + + + nematodes + + + + + + roundworm + + + + + roundworms + + + + + + Nemata + + + + + + nematodes + + + + + + + + + + + NCBITaxon:33251 + GC_ID:1 + ncbi_taxonomy + NCBITaxon:6236 + Rhabditida + + + + + + + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:6237 + Caenorhabditis + + + + + + + + + + NCBITaxon:54603 + GC_ID:1 + ncbi_taxonomy + NCBITaxon:6243 + Rhabditidae + @@ -184752,24 +185163,25 @@ plexiform layer using GABA. - + GC_ID:1 arthropods ncbi_taxonomy arthropods + NCBITaxon:6656 Arthropoda arthropods - + arthropods - + @@ -184778,24 +185190,25 @@ plexiform layer using GABA. - + GC_ID:1 chordates ncbi_taxonomy chordates + NCBITaxon:7711 Chordata chordates - + chordates - + @@ -184804,31 +185217,31 @@ plexiform layer using GABA. - GC_ID:1 Vertebrata vertebrates ncbi_taxonomy vertebrates + NCBITaxon:7742 Vertebrata <vertebrates> Vertebrata - + vertebrates - + vertebrates - + @@ -184837,24 +185250,24 @@ plexiform layer using GABA. - GC_ID:1 Gnathostomata jawed vertebrates ncbi_taxonomy + NCBITaxon:7776 Gnathostomata <vertebrates> Gnathostomata - + jawed vertebrates - + @@ -184863,9 +185276,10 @@ plexiform layer using GABA. - + GC_ID:1 ncbi_taxonomy + NCBITaxon:8287 Sarcopterygii @@ -184875,17 +185289,18 @@ plexiform layer using GABA. - + GC_ID:1 Mus ncbi_taxonomy + NCBITaxon:862507 Mus <subgenus> Mus - + @@ -184894,9 +185309,9 @@ plexiform layer using GABA. - GC_ID:1 ncbi_taxonomy + NCBITaxon:88770 Panarthropoda @@ -184906,17 +185321,18 @@ plexiform layer using GABA. - + GC_ID:1 Craniata ncbi_taxonomy + NCBITaxon:89593 Craniata <chordates> Craniata - + @@ -184925,7 +185341,6 @@ plexiform layer using GABA. - GC_ID:1 eutherian mammals placental mammals @@ -184933,37 +185348,38 @@ plexiform layer using GABA. ncbi_taxonomy Placentalia placentals + NCBITaxon:9347 Eutheria eutherian mammals - + placental mammals - + placentals - + Placentalia - + placentals - + @@ -184972,31 +185388,32 @@ plexiform layer using GABA. - + GC_ID:1 primate ncbi_taxonomy Primata primates + NCBITaxon:9443 Primates primate - + Primata - + primates - + @@ -185005,9 +185422,10 @@ plexiform layer using GABA. - + GC_ID:1 ncbi_taxonomy + NCBITaxon:9526 Catarrhini @@ -185017,24 +185435,25 @@ plexiform layer using GABA. - + GC_ID:1 great apes ncbi_taxonomy Pongidae + NCBITaxon:9604 Hominidae great apes - + Pongidae - + @@ -185043,17 +185462,18 @@ plexiform layer using GABA. - + GC_ID:1 humans ncbi_taxonomy + NCBITaxon:9605 Homo humans - + @@ -185062,7 +185482,7 @@ plexiform layer using GABA. - + GC_ID:1 human man @@ -185076,26 +185496,26 @@ plexiform layer using GABA. human - + man - + h - PRO:DAN + PRO:DAN human - PRO:DAN + PRO:DAN @@ -185105,17 +185525,18 @@ plexiform layer using GABA. - + GC_ID:1 cat family ncbi_taxonomy + NCBITaxon:9681 Felidae cat family - + @@ -185124,9 +185545,10 @@ plexiform layer using GABA. - + GC_ID:1 ncbi_taxonomy + NCBITaxon:9682 Felis @@ -185136,7 +185558,7 @@ plexiform layer using GABA. - + NCBITaxon:36475 GC_ID:1 PMID:17600185 @@ -185155,7 +185577,7 @@ plexiform layer using GABA. cat - + @@ -185167,25 +185589,25 @@ plexiform layer using GABA. cats - + domestic cat - + Felis domesticus - + Felis silvestris catus - + @@ -185194,7 +185616,7 @@ plexiform layer using GABA. - + GC_ID:1 rodent ncbi_taxonomy @@ -185206,7 +185628,7 @@ plexiform layer using GABA. rodent - + @@ -185218,7 +185640,7 @@ plexiform layer using GABA. rodents - + @@ -186310,6 +186732,26 @@ plexiform layer using GABA. + + + + + A shape quality inhering in a bearer by virtue of the bearer's being partly divided into a determinate number of regions. + quality + PATO:0001979 + + + lobed + + + + + A shape quality inhering in a bearer by virtue of the bearer's being partly divided into a determinate number of regions. + ISBN:0881923214 + + + + @@ -187685,14 +188127,14 @@ plexiform layer using GABA. An amino acid chain that is produced de novo by ribosome-mediated translation of a genetically-encoded mRNA, and any derivatives thereof. - PRO:DAN - PRO:WCB + PRO:DAN + PRO:WCB natural protein - PRO:DAN + PRO:DAN @@ -187722,13 +188164,13 @@ plexiform layer using GABA. PMID:16382100 PMID:16460286 PMID:17579562 - PRO:WCB + PRO:WCB fam:TRPC - PRO:DAN + PRO:DAN @@ -187759,7 +188201,7 @@ plexiform layer using GABA. fam:TRPC[3/6/7] - PRO:DAN + PRO:DAN @@ -187789,13 +188231,13 @@ plexiform layer using GABA. A transient receptor potential cation channel TRPC3/6/7 that is a translation product of the human TRPC3 gene or a 1:1 ortholog thereof. - PRO:CNA + PRO:CNA TRPC3 - PRO:DNx + PRO:DNx @@ -187839,7 +188281,7 @@ plexiform layer using GABA. CD19 - PRO:DNx + PRO:DNx @@ -187869,7 +188311,7 @@ plexiform layer using GABA. CD34 - PRO:DNx + PRO:DNx @@ -187900,7 +188342,7 @@ plexiform layer using GABA. CD4 - PRO:DNx + PRO:DNx @@ -187951,19 +188393,19 @@ plexiform layer using GABA. A protein that is a translation product of the human PTPRC gene or a 1:1 ortholog thereof. It is composed of an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic protein-tyrosine phosphatase domains. Contains 1 to 3 copies of the Fibronectin type III domain (Pfam:PF00041) followed by two copies of the Protein-tyrosine phosphatase (Pfam:PF00102) domain. Receptor-type tyrosine-protein phosphatase C (CD45) regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T and B cells. Multiple isoforms of CD45 (180-235 kDa) can be generated asa result of alternative splicing of three variable exons 4(A), 5(B) and 6(C), encoding sequences at the N-terminal extracellular domain of the molecule. PMID:1351092 - PRO:CNA + PRO:CNA T200 - PRO:DNx + PRO:DNx PTPRC - PRO:DNx + PRO:DNx @@ -187992,13 +188434,13 @@ plexiform layer using GABA. An integrin alpha with A domain that is a translation product of the human ITGA2 gene or a 1:1 ortholog thereof. - PRO:CNA + PRO:CNA ITGA2 - PRO:DNx + PRO:DNx @@ -188031,13 +188473,13 @@ plexiform layer using GABA. An integrin alpha with A domain that is a translation product of the human ITGAE gene or a 1:1 ortholog thereof. - PRO:CNA + PRO:CNA ITGAE - PRO:DNx + PRO:DNx @@ -188073,7 +188515,7 @@ plexiform layer using GABA. ITGAM - PRO:DNx + PRO:DNx @@ -188119,7 +188561,7 @@ plexiform layer using GABA. ITGAX - PRO:DNx + PRO:DNx @@ -188150,14 +188592,14 @@ plexiform layer using GABA. A receptor-type tyrosine-protein phosphatase C that is a translation product of some mRNA giving rise to a protein with the amino acid sequence represented by UniProtKB:P08575-3 or a 1:1 ortholog thereof. PMID:1351092 - PRO:CNA - PRO:DAN + PRO:CNA + PRO:DAN PTPRC/iso:CD45RABC - PRO:DNx + PRO:DNx @@ -188180,14 +188622,14 @@ plexiform layer using GABA. A receptor-type tyrosine-protein phosphatase C isoform CD45R that is a translation product of some mRNA giving rise to a protein with the amino acid sequence represented by UniProtKB:P08575-8 or a 1:1 ortholog thereof. PMID:1351092 - PRO:CNA - PRO:DAN + PRO:CNA + PRO:DAN PTPRC/iso:CD45RA - PRO:DNx + PRO:DNx @@ -188212,8 +188654,8 @@ plexiform layer using GABA. A receptor-type tyrosine-protein phosphatase C that is a translation product of some mRNA giving rise to a protein with the amino acid sequence represented by UniProtKB:P08575-4 or a 1:1 ortholog thereof. PMID:1351092 - PRO:CNA - PRO:DAN + PRO:CNA + PRO:DAN @@ -188226,7 +188668,7 @@ plexiform layer using GABA. PTPRC/iso:CD45RO - PRO:DNx + PRO:DNx @@ -188273,13 +188715,13 @@ plexiform layer using GABA. A CD3 subunit with immunoglobulin domain that is a translation product of the human CD3E gene or a 1:1 ortholog thereof. - PRO:CNA + PRO:CNA CD3E - PRO:DNx + PRO:DNx @@ -188306,7 +188748,7 @@ plexiform layer using GABA. A protein with a domain composition consisting of a large extracellular domain, including five Ig-like C2-type domains followed by two copies of the Fibronectin type-III domain (Pfam:PF00041), a single-pass transmembrane domain and a short cytoplasmic C-terminal domain. - PRO:CNA + PRO:CNA @@ -188351,13 +188793,13 @@ plexiform layer using GABA. A neural cell adhesion molecule NCAM that is a translation product of the human NCAM1 gene or a 1:1 ortholog thereof. - PRO:CNA + PRO:CNA NCAM1 - PRO:DNx + PRO:DNx @@ -188416,7 +188858,7 @@ plexiform layer using GABA. LY75 - PRO:DNx + PRO:DNx @@ -188449,13 +188891,13 @@ plexiform layer using GABA. A protein that is a translation product of the human CD2 gene or a 1:1 ortholog thereof. - PRO:CNA + PRO:CNA CD2 - PRO:DNx + PRO:DNx @@ -188490,14 +188932,14 @@ plexiform layer using GABA. A protein that is a translation product of the human CD8A gene or a 1:1 ortholog thereof. CD8 is a transmembrane that is a co-receptor for MHC class-I antigen/T-cell receptor interaction. The most common form of CD8 is composed of a CD8 alpha and a CD8 beta chain. PMID:11114424 - PRO:CNA + PRO:CNA Wikipedia:CD8 CD8A - PRO:DNx + PRO:DNx @@ -188544,14 +188986,14 @@ plexiform layer using GABA. A protein that is a translation product of the human CD8B gene or a 1:1 ortholog thereof. CD8 is a transmembrane receptor that is a co-receptor for MHC class-I antigen/T-cell receptor interaction. The most common form of CD8 is composed of a CD8 alpha and a CD8 beta chain. - PRO:CNA + PRO:CNA Wikipedia:CD8 CD8B - PRO:DNx + PRO:DNx @@ -188602,8 +189044,8 @@ plexiform layer using GABA. A G-protein coupled receptor with a 7 transmembrane (secretin family) domain (Pfam:PF00002) preceded by an amino-terminal region containing one or more functional domains with adhesion-like motifs. PMID:12761335 - PRO:DAN - PRO:WCB + PRO:DAN + PRO:WCB @@ -188615,7 +189057,7 @@ plexiform layer using GABA. fam:adhesion - PRO:DAN + PRO:DAN @@ -188647,8 +189089,8 @@ plexiform layer using GABA. A G-protein coupled receptor that contains the 7 transmembrane receptor (rhodopsin family) domain (Pfam:PF00001), which includes 7 transmembrane helices (TMI-TM7) with 3 intracellular loops (IL1-IL3) and 3 extracellular loops (EL1-EL3) between the helices. The amino-terminal region is extracellular and the carboxyl-terminal region is intracellular. Rhodopsin-like G-protein coupled receptors (GPCRs) are unique among the several classes of GPCRs in that most have a very short amino-terminal segment and several characteristic sequence motifs, particularly NSxxNPxxY in TM7 and D/E-R-Y/F between TM3 and loop IL2. Most bind their ligands within a cavity between the TM regions. PMID:12761335 - PRO:DAN - PRO:WCB + PRO:DAN + PRO:WCB @@ -188666,7 +189108,7 @@ plexiform layer using GABA. fam:rhodopsin - PRO:DAN + PRO:DAN @@ -188689,7 +189131,7 @@ plexiform layer using GABA. A rhodopsin-like G-protein coupled receptor that in active form binds to one or more chemokines. PMID:12037138 - PRO:WCB + PRO:WCB PRO:XQ @@ -188710,8 +189152,8 @@ plexiform layer using GABA. A chemokine receptor that is a translation product of the human CCR1 or CCR3 genes, the mouse CCR1L1 gene, 1:1 orthologs thereof, or a semi-ortholog thereof. - PRO:DAN - PRO:WCB + PRO:DAN + PRO:WCB @@ -188743,13 +189185,13 @@ plexiform layer using GABA. A chemokine receptor that is a translation product of the human CCR2 gene or a 1:1 ortholog thereof. The preferred ligands include CCL2, CCL7, CCL8, CCL13. PMID:12037138 - PRO:WCB + PRO:WCB CCR2 - PRO:DNx + PRO:DNx @@ -188785,13 +189227,13 @@ plexiform layer using GABA. A chemokine receptor that is a translation product of the human CCR4 gene or a 1:1 ortholog thereof. The preferred ligands include CCL17 and CCL22. PMID:12037138 - PRO:WCB + PRO:WCB CCR4 - PRO:DNx + PRO:DNx @@ -188829,13 +189271,13 @@ plexiform layer using GABA. A chemokine receptor that is a translation product of the human CCR5 gene or a 1:1 ortholog thereof. The preferred ligands include CCL3, CCL4, CCL5, CCL8, CCL14. PMID:12037138 - PRO:WCB + PRO:WCB CCR5 - PRO:DNx + PRO:DNx @@ -188881,13 +189323,13 @@ plexiform layer using GABA. A chemokine receptor that is a translation product of the human CCR6 gene or a 1:1 ortholog thereof. The preferred ligand is CCL20. PMID:12037138 - PRO:WCB + PRO:WCB CCR6 - PRO:DNx + PRO:DNx @@ -188948,13 +189390,13 @@ plexiform layer using GABA. A chemokine receptor that is a translation product of the human CCR7 gene or a 1:1 ortholog thereof. The preferred ligands are CCL19 and CCL21. PMID:12037138 - PRO:WCB + PRO:WCB CCR7 - PRO:DNx + PRO:DNx @@ -189006,13 +189448,13 @@ plexiform layer using GABA. A chemokine receptor that is a translation product of the human CX3CR1 gene or a 1:1 ortholog thereof. The preferred ligand is CX3CL1. PMID:12037138 - PRO:WCB + PRO:WCB CX3CR1 - PRO:DNx + PRO:DNx @@ -189058,13 +189500,13 @@ plexiform layer using GABA. A chemokine receptor that is a translation product of the human CXCR3 gene or a 1:1 ortholog thereof. The preferred ligands include CXCL9, CXCL10, CXCL11. PMID:12037138 - PRO:WCB + PRO:WCB CXCR3 - PRO:DNx + PRO:DNx @@ -189117,13 +189559,13 @@ plexiform layer using GABA. A chemokine receptor that is a translation product of the human CXCR4 gene or a 1:1 ortholog thereof. The preferred ligand is CXCL12. PMID:12037138 - PRO:WCB + PRO:WCB CXCR4 - PRO:DNx + PRO:DNx @@ -189170,13 +189612,13 @@ plexiform layer using GABA. A chemokine receptor that is a translation product of the human CXCR5 gene or a 1:1 ortholog thereof. The preferred ligand is CXCL13. PMID:12037138 - PRO:WCB + PRO:WCB CXCR5 - PRO:DNx + PRO:DNx @@ -189215,7 +189657,7 @@ plexiform layer using GABA. A chemokine receptor whose active form binds interleukin-8 with high affinity. - PRO:WCB + PRO:WCB @@ -189249,13 +189691,13 @@ plexiform layer using GABA. A chemokine receptor CCR1/3/1L that is a translation product of the human CCR1 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB CCR1 - PRO:DNx + PRO:DNx @@ -189307,13 +189749,13 @@ plexiform layer using GABA. A chemokine receptor CCR1/3/1L that is a translation product of the human CCR3 gene or a 1:1 ortholog thereof. PMID:12037138 - PRO:WCB + PRO:WCB CCR3 - PRO:DNx + PRO:DNx @@ -189356,13 +189798,13 @@ plexiform layer using GABA. A high affinity interleukin-8 receptor that is a translation product of the human CXCR1 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB CXCR1 - PRO:DNx + PRO:DNx @@ -189407,13 +189849,13 @@ plexiform layer using GABA. A high affinity interleukin-8 receptor that is a translation product of the human CXCR2 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB CXCR2 - PRO:DNx + PRO:DNx @@ -189452,7 +189894,7 @@ plexiform layer using GABA. A protein that contains the ADP-ribosyl cyclase domain (Pfam:PF02267). - PRO:WCB + PRO:WCB @@ -189480,13 +189922,13 @@ plexiform layer using GABA. A protein that is a translation product of the human CD22 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB CD22 - PRO:DNx + PRO:DNx @@ -189531,13 +189973,13 @@ plexiform layer using GABA. A protein that is a translation product of the human MS4A1 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB MS4A1 - PRO:DNx + PRO:DNx @@ -189569,7 +190011,7 @@ plexiform layer using GABA. A protein that is a member of a family that includes translation products of genes CD86, CD276, ICOSLG, and others. These are membrane-anchored proteins with a small intracellular domain and an extracellular domain with signal sequence, an Immunoglobulin V-set domain (Pfam:PF07686), and a CD80-like C2-set immunoglobulin domain (Pfam:PF08205). - PRO:WCB + PRO:WCB @@ -189600,13 +190042,13 @@ plexiform layer using GABA. A protein that is a translation product of the human CLEC4C gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB CLEC4C - PRO:DNx + PRO:DNx @@ -189665,13 +190107,13 @@ plexiform layer using GABA. A protein that is a translation product of the human CD207 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB CD207 - PRO:DNx + PRO:DNx @@ -189705,13 +190147,13 @@ plexiform layer using GABA. A protein that is a translation product of the human CD209 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB CD209 - PRO:DNx + PRO:DNx @@ -189758,13 +190200,13 @@ plexiform layer using GABA. A protein that is a translation product of the human CD44 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB CD44 - PRO:DNx + PRO:DNx @@ -189826,13 +190268,13 @@ plexiform layer using GABA. A protein that is a translation product of the human CD48 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB CD48 - PRO:DNx + PRO:DNx @@ -189874,13 +190316,13 @@ plexiform layer using GABA. A protein that is a translation product of the human CD83 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB CD83 - PRO:DNx + PRO:DNx @@ -189919,13 +190361,13 @@ plexiform layer using GABA. A protein that is a translation product of the human SELL gene or a 1:1 ortholog thereof. It is a leukocyte adhesion receptor that play an important role in regulating the inflammatory response by mediating leukocyte tethering and rolling on adherent leukocytes. PMID:12403782 - PRO:JAN + PRO:JAN SELL - PRO:DNx + PRO:DNx @@ -189970,13 +190412,13 @@ plexiform layer using GABA. A protein that is a translation product of the human CD84 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB CD84 - PRO:DNx + PRO:DNx @@ -190028,13 +190470,13 @@ plexiform layer using GABA. A protein that is a translation product of the human BST2 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB BST2 - PRO:DNx + PRO:DNx @@ -190055,7 +190497,7 @@ plexiform layer using GABA. A protein that has a core domain structure of signal sequence, propeptide, five Cadherin domains (Pfam:PF00028), a transmembrane region, and a Cadherin cytoplasmic region (Pfam:PF01049). Cadherins function as adhesion molecules that mediate Ca2+-dependent cell-cell adhesion in solid tissues. - PRO:WCB + PRO:WCB @@ -190080,13 +190522,13 @@ plexiform layer using GABA. A protein that is a translation product of the human CEACAM8 gene or a 1:1 ortholog thereof. - PRO:CNA + PRO:CNA CEACAM8 - PRO:DNx + PRO:DNx @@ -190116,13 +190558,13 @@ plexiform layer using GABA. A protein that is a translation product of the human CR1 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB CR1 - PRO:DNx + PRO:DNx @@ -190156,13 +190598,13 @@ plexiform layer using GABA. A protein that is a translation product of the human CR2 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB CR2 - PRO:DNx + PRO:DNx @@ -190201,14 +190643,14 @@ plexiform layer using GABA. A protein that is a translation product of the human CD69 gene or a 1:1 ortholog thereof. A type II transmembrane protein with a C-type lectin binding domain in the extracellular portion of the molecule. Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets. PMID:10466080 - PRO:CNA + PRO:CNA UniProtKB:Q07108 CD69 - PRO:DNx + PRO:DNx @@ -190242,13 +190684,13 @@ plexiform layer using GABA. A protein that is a translation product of the human ENPP3 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB ENPP3 - PRO:DNx + PRO:DNx @@ -190281,13 +190723,13 @@ plexiform layer using GABA. A protein that is a translation product of the human ENG gene or a 1:1 ortholog thereof. - PRO:CNA + PRO:CNA ENG - PRO:DNx + PRO:DNx @@ -190323,13 +190765,13 @@ plexiform layer using GABA. A protein that is a translation product of the human FOXP3 gene or a 1:1 ortholog thereof. - PRO:CNA + PRO:CNA FOXP3 - PRO:DNx + PRO:DNx @@ -190363,7 +190805,7 @@ plexiform layer using GABA. A protein that contains an extracellular Glycophorin A domain (Pfam:PF01102), followed by a single-pass transmembrane region and a small intracellular domain. A protein that is an integral protein of the red cell membrane. Proteins in this class are responsible for the molecular basis of the blood group antigens, surface markers on the outside of the red blood cell membrane. InterPro:IPR001195 - PRO:CNA + PRO:CNA @@ -190383,7 +190825,7 @@ plexiform layer using GABA. A protein with a core domain architecture consisting of an extracellular domain containing two copies of the Immunoglobulin domain (Pfam:PF00047), followed by a single-pass transmembrane region and a small intracellular domain. The active protein is a low affinity receptor for immunoglobulin gamma chain Fc region. Human II-a, II-b, and II-c represent a recent gene expansion and are equally related to mouse II, III, and IV. Human III-A and III-B are closely related and closer to mouse IV than to mouse III. - PRO:WCB + PRO:WCB @@ -190404,7 +190846,7 @@ plexiform layer using GABA. A protein with a core domain architecture consisting of an extracellular domain containing two or three copies of the Immunoglobulin domain (Pfam:PF00047), followed by a single-pass transmembrane region and a small intracellular domain. - PRO:CNA + PRO:CNA @@ -190434,19 +190876,19 @@ plexiform layer using GABA. A protein that is a translation product of the human IL2RA gene or a 1:1 ortholog thereof. - PRO:CNA + PRO:CNA p55 - PRO:DNx + PRO:DNx IL2RA - PRO:DNx + PRO:DNx @@ -190482,19 +190924,19 @@ plexiform layer using GABA. A protein that is a translation product of the human IL2RB gene or a 1:1 ortholog thereof. - PRO:CNA + PRO:CNA p75 - PRO:DNx + PRO:DNx IL2RB - PRO:DNx + PRO:DNx @@ -190527,13 +190969,13 @@ plexiform layer using GABA. A leukocyte immunoglobulin-like receptor subfamily member that is a translation product of the human LILRA4 gene or a 1:1 ortholog thereof. This gene is a member of a lineage-specific gene expansion in primates. - PRO:WCB + PRO:WCB LILRA4 - PRO:DNx + PRO:DNx @@ -190564,13 +191006,13 @@ plexiform layer using GABA. A protein that is a translation product of the human KLRD1 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB KLRD1 - PRO:DNx + PRO:DNx @@ -190591,7 +191033,7 @@ plexiform layer using GABA. A protein with four transmembrane domains, small intracellular amino- and carboxyl-terminal regions, and two extracellular loops, a small one (EC1) and a larger one (EC2) of about 100 residues. The EC2 loop contains at least 4 cysteine residues, including a highly conserved 'CCG' motif. - PRO:WCB + PRO:WCB Wikipedia:Tetraspanin @@ -190623,13 +191065,13 @@ plexiform layer using GABA. An ADP-ribosyl cyclase that is a translation product of the human CD38 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB CD38 - PRO:DNx + PRO:DNx @@ -190662,13 +191104,13 @@ plexiform layer using GABA. A B7-related protein that is a translation product of the human CD86 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB CD86 - PRO:DNx + PRO:DNx @@ -190698,8 +191140,8 @@ plexiform layer using GABA. A rhodopsin-like G-protein coupled receptor that is a translation product of the human FPR1, FPR2, or FPR3 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds N-formyl methionyl peptides. InterPro:IPR000826 - PRO:DAN - PRO:WCB + PRO:DAN + PRO:WCB PRO:XQ @@ -190735,13 +191177,13 @@ plexiform layer using GABA. A B7-related protein that is a translation product of the human CD80 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB CD80 - PRO:DNx + PRO:DNx @@ -190784,13 +191226,13 @@ plexiform layer using GABA. A cadherin that is a translation product of the human CDH5 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB CDH5 - PRO:DNx + PRO:DNx @@ -190819,13 +191261,13 @@ plexiform layer using GABA. A cadherin that is a translation product of the human CDH1 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB CDH1 - PRO:DNx + PRO:DNx @@ -190869,19 +191311,19 @@ plexiform layer using GABA. An alpha-(1,3)-fucosyltransferase that is a translation product of the human FUT4 gene or a 1:1 ortholog thereof. - PRO:CNA + PRO:CNA galactoside 3-L-fucosyltransferase - PRO:DNx + PRO:DNx FUT4 - PRO:DNx + PRO:DNx @@ -190920,13 +191362,13 @@ plexiform layer using GABA. A glycophorin that is a translation product of the human GYPA gene or a 1:1 ortholog thereof. It is the major sialoglycoprotein of the erythrocyte membrane. Structurally, glycophorin A consists of an N-terminal extracellular domain, heavily glycosylated on Ser and threonine residues, followed by a transmembrane region and a C-terminal cytoplasmic domain. InterPro:IPR001195 - PRO:CNA + PRO:CNA GYPA - PRO:DNx + PRO:DNx @@ -190960,13 +191402,13 @@ plexiform layer using GABA. An immunoglobulin gamma Fc receptor I that is a translation product of the human FCGR1A gene or a 1:1 ortholog thereof. - PRO:CNA + PRO:CNA FCGR1A - PRO:DNx + PRO:DNx @@ -191014,19 +191456,19 @@ plexiform layer using GABA. An immunoglobulin gamma Fc receptor II/III/IV that is a translation product of the mouse Fcgr2 gene or a 1:1 ortholog thereof. - PRO:CNA + PRO:CNA CD32 - PRO:DNx + PRO:DNx Fcgr2 - PRO:DNx + PRO:DNx @@ -191061,26 +191503,26 @@ plexiform layer using GABA. An immunoglobulin gamma Fc receptor II/III/IV that is a translation product of the human FCGR2B gene or a 1:1 ortholog thereof. - PRO:CNA + PRO:CNA CD32 - PRO:DNx + PRO:DNx CDw32 - PRO:DNx + PRO:DNx FCGR2B - PRO:DNx + PRO:DNx @@ -191117,13 +191559,13 @@ plexiform layer using GABA. An immunoglobulin gamma Fc receptor II/III/IV that is a translation product of the mouse Fcgr3 gene or a 1:1 ortholog thereof. - PRO:CNA + PRO:CNA Fcgr3 - PRO:DNx + PRO:DNx @@ -191152,13 +191594,13 @@ plexiform layer using GABA. A prostanoid receptor that is a translation product of the human PTGDR2 gene or a 1:1 ortholog thereof. The preferred ligand is 11-dehydro-thromboxane B2. This receptor is not closely related to the prostaglandin D2 receptor encoded by PGD2. - PRO:WCB + PRO:WCB PTGDR2 - PRO:DNx + PRO:DNx @@ -191199,7 +191641,7 @@ plexiform layer using GABA. A rhodopsin-like G-protein coupled receptor that is a translation product of the human PTGDR, PTGDR2, PTGER1 to PTGER4, PTGFR, PTGIR, or TBXA2R genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds prostanoids (prostaglandins and thromboxanes). PMID:7938166 - PRO:WCB + PRO:WCB PRO:XQ @@ -191226,19 +191668,19 @@ plexiform layer using GABA. An N-formyl peptide receptor that is a translation product of the human FPR1 gene or a 1:1 ortholog thereof. The preferred ligand is the peptide fMet-Leu-Phe, a bacterial peptide that acts as a chemoattractant in various pathophysiological conditions. InterPro:IPR000826 - PRO:WCB + PRO:WCB N-formyl peptide receptor - PRO:DNx + PRO:DNx FPR1 - PRO:DNx + PRO:DNx @@ -191260,7 +191702,7 @@ plexiform layer using GABA. A protein with a core domain composition consisting of a Rel homology domain (RHD) (Pfam:PF00554), an IPT/TIG domain (Pfam:PF01833), six copies of the Ankyrin repeat (Pfam:PF00023), a Death domain (Pfam:PF00531) and a C-terminal PEST region. - PRO:JAN + PRO:JAN @@ -191309,13 +191751,13 @@ plexiform layer using GABA. A prominin that is a translation product of the human PROM1 gene or a 1:1 ortholog thereof. - PRO:CNA + PRO:CNA PROM1 - PRO:DNx + PRO:DNx @@ -191362,13 +191804,13 @@ plexiform layer using GABA. A protein that is a translation product of the human CLEC6A gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB CLEC6A - PRO:DNx + PRO:DNx @@ -191418,13 +191860,13 @@ plexiform layer using GABA. A protein that is a translation product of the human CLEC7A gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB CLEC7A - PRO:DNx + PRO:DNx @@ -191469,7 +191911,7 @@ plexiform layer using GABA. A protein that is a translation product of the human CD59 gene, a 1:1 ortholog thereof, or pro-orthologs thereof. This gene is present as a single copy in human and has undergone a lineage-specific duplication in mouse. CD59 antigen has a core architecture consisting of one UPAR/Ly-6 domain (Pfam:PF00021), a small domain of about 70 amino acids and containing 5 conserved disulfide bonds. It is both N- and O-glycosylated and is a GPI-anchored protein that releases soluble forms in some tissues. - PRO:WCB + PRO:WCB @@ -191489,7 +191931,7 @@ plexiform layer using GABA. A protein with core architecture consisting of asignal sequence, 5 Ig-like domains, followed by a transmembrane sequence, followed by a Protein tyrosine kinase domain (Pfam:PF07714). However, only 1-3 of the Ig domains are detected by the Pfam HMMs in most of the sequences. Pfam:PF00047 is most common, but other members of the Ig domain clan, Pfam:PF07679 and Pfam:PF07686 can be identified instead. The fourth Ig domain lacks the disulfide-bonded cysteines. - PRO:WCB + PRO:WCB @@ -191518,21 +191960,21 @@ plexiform layer using GABA. An adhesion G-protein coupled receptor that is a translation product of the human ADGRE1 gene or a 1:1 ortholog thereof. - PRO:DAN - PRO:WCB + PRO:DAN + PRO:WCB ADGRE1 - PRO:DNx + PRO:DNx EMR1 - PRO:DNx + PRO:DNx @@ -191564,14 +192006,14 @@ plexiform layer using GABA. A protein with core architecture consisting of a signal sequence, a Class II histocompatibility antigen, alpha domain (Pfam:PF00993) and an Immunoglobulin C1-set domain (Pfam:PF07654); these form the extracellular domain and are followed by a single-pass transmembrane region and a small cytoplasmic region. - PRO:WCB + PRO:WCB Wikipedia:Human_leukocyte_antigen MHCcIIalpha - PRO:DAN + PRO:DAN @@ -191592,7 +192034,7 @@ plexiform layer using GABA. A protein with core architecture consisting of a signal sequence, one Immunoglobulin V-set domain (Pfam:PF07686), two Immunoglobulin C1-set domains (Pfam:PF07654), a single-pass transmembrane region and a very small cytoplasmic region. - PRO:WCB + PRO:WCB @@ -191617,13 +192059,13 @@ plexiform layer using GABA. A protein that is a translation product of the human SLAMF1 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB SLAMF1 - PRO:DNx + PRO:DNx @@ -191655,13 +192097,13 @@ plexiform layer using GABA. A protein that is a translation product of the human TBX21 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB TBX21 - PRO:DNx + PRO:DNx @@ -191700,13 +192142,13 @@ plexiform layer using GABA. A protein that is a translation product of the human CD7 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB CD7 - PRO:DNx + PRO:DNx @@ -191728,13 +192170,13 @@ plexiform layer using GABA. A protein with core architecture consisting of a signal sequence, an extracellular region with Class I Histocompatibility antigen, domains alpha 1 and alpha two (Pfam:PF00129) and an Immunoglobulin C1-set domain (Pfam:PF07654), a single-pass transmembrane region, and a very short cytoplasmic region. Forms a heterodimer with beta-2 microglobulin. - PRO:WCB + PRO:WCB CD1 - PRO:DAN + PRO:DAN @@ -191761,13 +192203,13 @@ plexiform layer using GABA. A protein that is a translation product of the human CD5 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB CD5 - PRO:DNx + PRO:DNx @@ -191796,13 +192238,13 @@ plexiform layer using GABA. A protein that is a translation product of the human CD28 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB CD28 - PRO:DNx + PRO:DNx @@ -191828,13 +192270,13 @@ plexiform layer using GABA. A protein that is a translation product of the human THY1 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB THY1 - PRO:DNx + PRO:DNx @@ -191864,13 +192306,13 @@ plexiform layer using GABA. A protein that is a translation product of the human ARG1 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB ARG1 - PRO:DNx + PRO:DNx @@ -191897,14 +192339,14 @@ plexiform layer using GABA. A cathepsin-like protease that is a translation product of the human CTSK gene or a 1:1 ortholog thereof. - PRO:DAN - PRO:WCB + PRO:DAN + PRO:WCB CTSK - PRO:DNx + PRO:DNx @@ -191941,13 +192383,13 @@ plexiform layer using GABA. A protein that is a translation product of the human CTLA4 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB CTLA4 - PRO:DNx + PRO:DNx @@ -191975,13 +192417,13 @@ plexiform layer using GABA. A protein that is a translation product of the human VPREB1 gene or a 1:1 ortholog thereof. The gene is recently and independently duplicated in mouse and rabbit, giving rise to very closely related VPREB2 genes in those species. The protein associates with the Ig-mu chain to form a molecular complex that is expressed only on the surface of pre-B-cells. - PRO:WCB + PRO:WCB VPREB1 - PRO:DNx + PRO:DNx @@ -192015,13 +192457,13 @@ plexiform layer using GABA. A protein that is a translation product of the human IGLL1 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB IGLL1 - PRO:DNx + PRO:DNx @@ -192056,13 +192498,13 @@ plexiform layer using GABA. A protein that is a translation product of the human ICOS gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB ICOS - PRO:DNx + PRO:DNx @@ -192089,7 +192531,7 @@ plexiform layer using GABA. A protein with core architecture consisting of a large extracellular region containing one Integrin, beta chain domain (Pfam:PF00362), up to four EGF-like domains (Pfam:PF07974), and an Integrin beta tail domain (Pfam:PF07965), followed by a single-pass transmembrane region and a small cytoplasmic region often containing an Integrin beta cytoplasmic domain (Pfam:PF08725). - PRO:WCB + PRO:WCB @@ -192118,13 +192560,13 @@ plexiform layer using GABA. A protein that is a translation product of the human IL3RA gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB IL3RA - PRO:DNx + PRO:DNx @@ -192166,13 +192608,13 @@ plexiform layer using GABA. A protein that is a translation product of the human IL5RA gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB IL5RA - PRO:DNx + PRO:DNx @@ -192207,13 +192649,13 @@ plexiform layer using GABA. A protein that is a translation product of the human IL7R gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB IL7R - PRO:DNx + PRO:DNx @@ -192234,7 +192676,7 @@ plexiform layer using GABA. A protein that is a translation product of the KLRB1 gene or its closely related paralogs (KLRB1A-F). There are lineage-specific expansions in mouse and rat. - PRO:WCB + PRO:WCB @@ -192263,13 +192705,13 @@ plexiform layer using GABA. A protein that is a translation product of the human SPN gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB SPN - PRO:DNx + PRO:DNx @@ -192303,13 +192745,13 @@ plexiform layer using GABA. A protein that is a translation product of the human FCER2 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB FCER2 - PRO:DNx + PRO:DNx @@ -192360,7 +192802,7 @@ plexiform layer using GABA. A protein with core architecture consisting of a Lysosome-associated membrane glycoprotein (Pfam:PF01299) domain. It is a single-pass type I membrane protein that shuttles between lysosomes, endosomes, and the plasma membrane. - PRO:WCB + PRO:WCB @@ -192383,13 +192825,13 @@ plexiform layer using GABA. A protein that is a translation product of the human MARCO gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB MARCO - PRO:DNx + PRO:DNx @@ -192423,13 +192865,13 @@ plexiform layer using GABA. A protein that is a translation product of the human MSR1 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB MSR1 - PRO:DNx + PRO:DNx @@ -192462,7 +192904,7 @@ plexiform layer using GABA. A protein with core architecture consisting of a Peptidase family M1 domain (Pfam:PF01433). - PRO:WCB + PRO:WCB @@ -192485,13 +192927,13 @@ plexiform layer using GABA. A protein that is a translation product of the human CD14 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB CD14 - PRO:DNx + PRO:DNx @@ -192518,13 +192960,13 @@ plexiform layer using GABA. A protein that is a translation product of the human CD33 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB CD33 - PRO:DNx + PRO:DNx @@ -192561,19 +193003,19 @@ plexiform layer using GABA. A protein that is a translation product of the human NCR1 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB NK cell-activating receptor - PRO:DNx + PRO:DNx NCR1 - PRO:DNx + PRO:DNx @@ -192608,19 +193050,19 @@ plexiform layer using GABA. A protein that is a translation product of the human NCR2 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB NK cell-activating receptor - PRO:DNx + PRO:DNx NCR2 - PRO:DNx + PRO:DNx @@ -192657,13 +193099,13 @@ plexiform layer using GABA. A protein that is a translation product of the human CD244 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB CD244 - PRO:DNx + PRO:DNx @@ -192696,7 +193138,7 @@ plexiform layer using GABA. A protein with core architecture consisting of an as yet unnamed domain in the amino-terminal half and a carboxyl-terminal Lectin C-type domain (Pfam:PF00059). - PRO:WCB + PRO:WCB @@ -192729,13 +193171,13 @@ plexiform layer using GABA. A protein that is a translation product of the human MME gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB MME - PRO:DNx + PRO:DNx @@ -192773,13 +193215,13 @@ plexiform layer using GABA. A protein that is a translation product of the human RORC gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB RORC - PRO:DNx + PRO:DNx @@ -192827,13 +193269,13 @@ plexiform layer using GABA. A protein that is a translation product of the human PAX5 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB PAX5 - PRO:DNx + PRO:DNx @@ -192873,13 +193315,13 @@ plexiform layer using GABA. A protein that is a translation product of the human CD36 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB CD36 - PRO:DNx + PRO:DNx @@ -192919,13 +193361,13 @@ plexiform layer using GABA. A protein that is a translation product of the human GP1BA gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB GP1BA - PRO:DNx + PRO:DNx @@ -192952,13 +193394,13 @@ plexiform layer using GABA. A protein that is a translation product of the human PDCD1 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB PDCD1 - PRO:DNx + PRO:DNx @@ -192987,13 +193429,13 @@ plexiform layer using GABA. A protein that is a translation product of the human CD163 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB CD163 - PRO:DNx + PRO:DNx @@ -193031,13 +193473,13 @@ plexiform layer using GABA. A protein that is a translation product of the human SIGLEC5 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB SIGLEC5 - PRO:DNx + PRO:DNx @@ -193077,13 +193519,13 @@ plexiform layer using GABA. A protein that is a translation product of the human SIGLEC1 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB SIGLEC1 - PRO:DNx + PRO:DNx @@ -193125,13 +193567,13 @@ plexiform layer using GABA. A protein that is a translation product of the human CD24 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB CD24 - PRO:DNx + PRO:DNx @@ -193163,13 +193605,13 @@ plexiform layer using GABA. A protein that is a translation product of the human SDC1 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB SDC1 - PRO:DNx + PRO:DNx @@ -193209,13 +193651,13 @@ plexiform layer using GABA. A protein that is a translation product of the human ACP5 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB ACP5 - PRO:DNx + PRO:DNx @@ -193248,7 +193690,7 @@ plexiform layer using GABA. A protein with core architecture consisting of a signal sequence, a Lectin C-type domain (Pfam:PF00059), 5 or 6 EGF-like domains (Pfam:PF00008, Pfam:PF09064, or Pfam:PF07645), a transmembrane region, and a small cytoplasmic region (36-51 amino acids). - PRO:WCB + PRO:WCB @@ -193270,13 +193712,13 @@ plexiform layer using GABA. A protein that is a translation product of the human GATA3 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB GATA3 - PRO:DNx + PRO:DNx @@ -193307,13 +193749,13 @@ plexiform layer using GABA. A protein that is a translation product of the human SPI1 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB SPI1 - PRO:DNx + PRO:DNx @@ -193353,19 +193795,19 @@ plexiform layer using GABA. A protein that is a translation product of the human TFRC gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB p90 - PRO:DNx + PRO:DNx TFRC - PRO:DNx + PRO:DNx @@ -193394,20 +193836,20 @@ plexiform layer using GABA. A protein that is a translation product of the human CD40LG gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB TRAP - PRO:DNx + PRO:DNx CD40LG - PRO:DNx + PRO:DNx @@ -193447,13 +193889,13 @@ plexiform layer using GABA. A protein that is a translation product of the human TNFRSF11A gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB TNFRSF11A - PRO:DNx + PRO:DNx @@ -193487,13 +193929,13 @@ plexiform layer using GABA. A protein that is a translation product of the human CD27 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB CD27 - PRO:DNx + PRO:DNx @@ -193543,19 +193985,19 @@ plexiform layer using GABA. A SIRP/SHPS-1 family protein that is a translation product of the human SIRPA gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB p84 - PRO:DNx + PRO:DNx SIRPA - PRO:DNx + PRO:DNx @@ -193619,13 +194061,13 @@ plexiform layer using GABA. A protein that is a translation product of the human PLAUR gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB PLAUR - PRO:DNx + PRO:DNx @@ -193658,7 +194100,7 @@ plexiform layer using GABA. A protein with core architecture consisting of a signal sequence, followed by 7 Ig-like domains (Pfam:PF00047, Pfam:PF07679, or Pfam:PF07686), a transmembrane region, and a cytoplasmic Protein tyrosine kinase domain. - PRO:WCB + PRO:WCB @@ -193693,13 +194135,13 @@ plexiform layer using GABA. A CSF-1/PDGF receptor-type tyrosine-protein kinase that is a translation product of the human FLT3 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB FLT3 - PRO:DNx + PRO:DNx @@ -193737,13 +194179,13 @@ plexiform layer using GABA. An MHC class II histocompatibility antigen alpha chain that is a translation product of the human HLA-DRA gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB MHCcIIalpha_DRA - PRO:DAN + PRO:DAN @@ -193782,13 +194224,13 @@ plexiform layer using GABA. A natural killer cell receptor NKG2 that is a translation product of the human KLRC1 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB KLRC1 - PRO:DNx + PRO:DNx @@ -193818,13 +194260,13 @@ plexiform layer using GABA. A T-cell surface glycoprotein CD1 that is a translation product of the human CD1A gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB CD1A - PRO:DNx + PRO:DNx @@ -193846,13 +194288,13 @@ plexiform layer using GABA. A T-cell surface glycoprotein CD1 that is a translation product of the human CD1C gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB CD1C - PRO:DNx + PRO:DNx @@ -193879,13 +194321,13 @@ plexiform layer using GABA. A T-cell surface glycoprotein CD1 that is a translation product of the human CD1D gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB CD1D - PRO:DNx + PRO:DNx @@ -193930,13 +194372,13 @@ plexiform layer using GABA. A CSF-1/PDGF receptor-type tyrosine-protein kinase that is a translation product of the human PDGFRA gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB PDGFRA - PRO:DNx + PRO:DNx @@ -193983,13 +194425,13 @@ plexiform layer using GABA. A membrane alanyl aminopeptidase-like metallopeptidase that is a translation product of the human ANPEP gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB ANPEP - PRO:DNx + PRO:DNx @@ -194048,13 +194490,13 @@ plexiform layer using GABA. A thrombomodulin-like receptor that is a translation product of the human CD93 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB CD93 - PRO:DNx + PRO:DNx @@ -194106,13 +194548,13 @@ plexiform layer using GABA. A membrane alanyl aminopeptidase-like metallopeptidase that is a translation product of the human ENPEP gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB ENPEP - PRO:DNx + PRO:DNx @@ -194143,13 +194585,13 @@ plexiform layer using GABA. A CSF-1/PDGF receptor-type tyrosine-protein kinase that is a translation product of the human CSF1R gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB CSF1R - PRO:DNx + PRO:DNx @@ -194183,13 +194625,13 @@ plexiform layer using GABA. A lysosome-associated membrane protein that is a translation product of the human CD68 gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB CD68 - PRO:DNx + PRO:DNx @@ -194217,13 +194659,13 @@ plexiform layer using GABA. A CSF-1/PDGF receptor-type tyrosine-protein kinase that is a translation product of the human KIT gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB KIT - PRO:DNx + PRO:DNx @@ -194256,7 +194698,7 @@ plexiform layer using GABA. A thrombomodulin-like receptor that is a translation product of the human THBD gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB @@ -194274,7 +194716,7 @@ plexiform layer using GABA. THBD - PRO:DNx + PRO:DNx @@ -194311,13 +194753,13 @@ plexiform layer using GABA. A vascular endothelial growth factor receptor that is a translation product of the human KDR gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB KDR - PRO:DNx + PRO:DNx @@ -194359,13 +194801,13 @@ plexiform layer using GABA. A C-type lectin with multiple lectin domains that is a translation product of the human MRC1 gene or a 1:1 ortholog thereof. PMID:8297379 - PRO:CNA + PRO:CNA MRC1 - PRO:DNx + PRO:DNx @@ -194404,7 +194846,7 @@ plexiform layer using GABA. A protein that is the translation product of any of the LY6 genes (LY6A-LY6I). - PRO:CNA + PRO:CNA @@ -194435,13 +194877,13 @@ plexiform layer using GABA. A KLRB1-like protein that is a translation product of the mouse Klrb1c gene or a 1:1 ortholog thereof. - PRO:CNA + PRO:CNA Klrb1c - PRO:DNx + PRO:DNx @@ -194476,13 +194918,13 @@ plexiform layer using GABA. An Ly-6-like protein that is a translation product of the mouse Ly6g gene or a 1:1 ortholog thereof. - PRO:CNA + PRO:CNA Ly6g - PRO:DNx + PRO:DNx @@ -194509,13 +194951,13 @@ plexiform layer using GABA. An Ly-6-like protein that is a translation product of the mouse Ly6a gene or a 1:1 ortholog thereof. - PRO:CNA + PRO:CNA Ly6a - PRO:DNx + PRO:DNx @@ -194544,13 +194986,13 @@ plexiform layer using GABA. An Ly-6-like protein that is a translation product of the mouse Ly6c2 gene or a 1:1 ortholog thereof. - PRO:CNA + PRO:CNA Ly6c2 - PRO:DNx + PRO:DNx @@ -194601,13 +195043,13 @@ plexiform layer using GABA. A protein that is a translation product of the Ly76 gene in mouse. PMID:10848813 - PRO:DAN + PRO:DAN mLy76 - PRO:DNx + PRO:DNx @@ -194648,8 +195090,8 @@ plexiform layer using GABA. A collagen alpha chain that is a translation product of the human COL1A1 or COL1A2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. - PRO:CNA - PRO:DAN + PRO:CNA + PRO:DAN @@ -194671,13 +195113,13 @@ plexiform layer using GABA. A collagen type I alpha chain that is a translation product of the human COL1A1 gene or a 1:1 ortholog thereof. - PRO:CNA + PRO:CNA COL1A1 - PRO:DNx + PRO:DNx @@ -194715,13 +195157,13 @@ plexiform layer using GABA. A protein that is a translation product of the human BCL6 gene or a 1:1 ortholog thereof. - PRO:CNA + PRO:CNA BCL6 - PRO:DNx + PRO:DNx @@ -194766,13 +195208,13 @@ plexiform layer using GABA. A nuclear receptor ROR-gamma that is a translation product of some mRNA giving rise to a protein with the amino acid sequence represented by UniProtKB:P51450-2 or a 1:1 ortholog thereof. - PRO:CNA + PRO:CNA RORC/iso:2 - PRO:DNx + PRO:DNx @@ -194796,13 +195238,13 @@ plexiform layer using GABA. A protein that is a translation product of the human RAG1 gene or a 1:1 ortholog thereof. - PRO:CNA + PRO:CNA RAG1 - PRO:DNx + PRO:DNx @@ -194830,13 +195272,13 @@ plexiform layer using GABA. A protein that is a translation product of the human RAG2 gene or a 1:1 ortholog thereof. - PRO:CNA + PRO:CNA RAG2 - PRO:DNx + PRO:DNx @@ -194862,13 +195304,13 @@ plexiform layer using GABA. A T-brain transcription factor that is a translation product of the human EOMES gene or a 1:1 ortholog thereof. PMID:10407135 - PRO:CNA + PRO:CNA EOMES - PRO:DNx + PRO:DNx @@ -194899,13 +195341,13 @@ plexiform layer using GABA. A protein that is a translation product of the human PRF1 gene or a 1:1 ortholog thereof. - PRO:CNA + PRO:CNA PRF1 - PRO:DNx + PRO:DNx @@ -194933,13 +195375,13 @@ plexiform layer using GABA. A protein that is a translation product of the human EGR2 gene or a 1:1 ortholog thereof. - PRO:CNA + PRO:CNA EGR2 - PRO:DNx + PRO:DNx @@ -194994,25 +195436,25 @@ plexiform layer using GABA. A leukocyte granule-associated proteinase that is a translation product of the human GZMB gene or a 1:1 ortholog thereof. - PRO:CNA + PRO:CNA CTLA-1 - PRO:DNx + PRO:DNx fragmentin-2 - PRO:DNx + PRO:DNx GZMB - PRO:DNx + PRO:DNx @@ -195109,19 +195551,19 @@ plexiform layer using GABA. A protein that is a translation product of the human A4GALT gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx alpha-1,4-N-acetylglucosaminyltransferase - PRO:DNx + PRO:DNx A4GALT - PRO:DNx + PRO:DNx @@ -195154,13 +195596,13 @@ plexiform layer using GABA. A protein that is a translation product of the human CCK gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx CCK - PRO:DNx + PRO:DNx @@ -195193,19 +195635,19 @@ plexiform layer using GABA. A tetraspanin that is a translation product of the human CD9 gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx p24 - PRO:DNx + PRO:DNx CD9 - PRO:DNx + PRO:DNx @@ -195246,13 +195688,13 @@ plexiform layer using GABA. A protein that is a translation product of the human CEBPA gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx CEBPA - PRO:DNx + PRO:DNx @@ -195281,13 +195723,13 @@ plexiform layer using GABA. A protein that is a translation product of the human CEBPE gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx CEBPE - PRO:DNx + PRO:DNx @@ -195317,13 +195759,13 @@ plexiform layer using GABA. A nicotinic acetylcholine receptor protein that is a translation product of the human CHRNA7 gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx CHRNA7 - PRO:DNx + PRO:DNx @@ -195361,13 +195803,13 @@ plexiform layer using GABA. A protein that is a translation product of the mouse Cd200r3 gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx Cd200r3 - PRO:DNx + PRO:DNx @@ -195391,13 +195833,13 @@ plexiform layer using GABA. A protein that is a translation product of the mouse Cd209b gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx Cd209b - PRO:DNx + PRO:DNx @@ -195422,13 +195864,13 @@ plexiform layer using GABA. A protein that is a translation product of the human DNTT gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx DNTT - PRO:DNx + PRO:DNx @@ -195452,20 +195894,20 @@ plexiform layer using GABA. A protein that is a translation product of the human EPX gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx EPO - PRO:DNx + PRO:DNx EPX - PRO:DNx + PRO:DNx @@ -195503,13 +195945,13 @@ plexiform layer using GABA. An immunoglobulin gamma Fc receptor II/III/IV that is a translation product of the human FCER1A gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx FCER1A - PRO:DNx + PRO:DNx @@ -195540,13 +195982,13 @@ plexiform layer using GABA. A protein that is a translation product of the human FOS gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx FOS - PRO:DNx + PRO:DNx @@ -195580,13 +196022,13 @@ plexiform layer using GABA. A protein that is a translation product of the human GATA1 gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx GATA1 - PRO:DNx + PRO:DNx @@ -195620,13 +196062,13 @@ plexiform layer using GABA. A protein that is a translation product of the human GATA2 gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx GATA2 - PRO:DNx + PRO:DNx @@ -195647,13 +196089,13 @@ plexiform layer using GABA. A protein that is a translation product of the human GFAP gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx GFAP - PRO:DNx + PRO:DNx @@ -195674,13 +196116,13 @@ plexiform layer using GABA. A hemoglobin subunit that is a translation product of the human HBB gene, a 1:1 ortholog thereof, or pro-orthologs thereof. - PRO:DAN + PRO:DAN b-globin - PRO:DNx + PRO:DNx @@ -195708,13 +196150,13 @@ plexiform layer using GABA. A hemoglobin subunit that is a translation product of the human HBZ gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx HBZ - PRO:DNx + PRO:DNx @@ -195756,13 +196198,13 @@ plexiform layer using GABA. A beta-globin that is a translation product of the mouse Hbb-b1 gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx Hbb-b1 - PRO:DNx + PRO:DNx @@ -195797,13 +196239,13 @@ plexiform layer using GABA. A protein that is a translation product of the human IL17RB gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx IL17RB - PRO:DNx + PRO:DNx @@ -195857,13 +196299,13 @@ plexiform layer using GABA. A protein that is a translation product of the human IL1RL1 gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx IL1RL1 - PRO:DNx + PRO:DNx @@ -195921,13 +196363,13 @@ plexiform layer using GABA. An integrin alpha lacking A domain that is a translation product of the human ITGA2B gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx ITGA2B - PRO:DNx + PRO:DNx @@ -195968,13 +196410,13 @@ plexiform layer using GABA. An integrin alpha lacking A domain that is a translation product of the human ITGA4 gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx ITGA4 - PRO:DNx + PRO:DNx @@ -196005,13 +196447,13 @@ plexiform layer using GABA. An integrin beta that is a translation product of the human ITGB7 gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx ITGB7 - PRO:DNx + PRO:DNx @@ -196040,13 +196482,13 @@ plexiform layer using GABA. A protein that is a translation product of the human KLRG1 gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx KLRG1 - PRO:DNx + PRO:DNx @@ -196091,13 +196533,13 @@ plexiform layer using GABA. A protein that is a translation product of the mouse Klra1 gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx Klra1 - PRO:DNx + PRO:DNx @@ -196141,13 +196583,13 @@ plexiform layer using GABA. A protein that is a translation product of the mouse Klra3 gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx Klra3 - PRO:DNx + PRO:DNx @@ -196179,13 +196621,13 @@ plexiform layer using GABA. A protein that is a translation product of the mouse Klra4 gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx Klra4 - PRO:DNx + PRO:DNx @@ -196223,13 +196665,13 @@ plexiform layer using GABA. A protein that is a translation product of the mouse Klra8 gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx Klra8 - PRO:DNx + PRO:DNx @@ -196269,19 +196711,19 @@ plexiform layer using GABA. A protein that is a translation product of the human LCN2 gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx p25 - PRO:DNx + PRO:DNx LCN2 - PRO:DNx + PRO:DNx @@ -196321,13 +196763,13 @@ plexiform layer using GABA. A protein that is a translation product of the human LGALS1 gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx LGALS1 - PRO:DNx + PRO:DNx @@ -196360,13 +196802,13 @@ plexiform layer using GABA. A protein that is a translation product of the human LHX3 gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx LHX3 - PRO:DNx + PRO:DNx @@ -196409,13 +196851,13 @@ plexiform layer using GABA. A protein that is a translation product of the human LTF gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx LTF - PRO:DNx + PRO:DNx @@ -196453,13 +196895,13 @@ plexiform layer using GABA. A protein that is a translation product of the human LUM gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx LUM - PRO:DNx + PRO:DNx @@ -196501,13 +196943,13 @@ plexiform layer using GABA. A protein that is a translation product of the human MEIS2 gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx MEIS2 - PRO:DNx + PRO:DNx @@ -196545,13 +196987,13 @@ plexiform layer using GABA. A protein that is a translation product of the human MERTK gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx MERTK - PRO:DNx + PRO:DNx @@ -196579,13 +197021,13 @@ plexiform layer using GABA. A protein that is a translation product of the human MPO gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx MPO - PRO:DNx + PRO:DNx @@ -196607,13 +197049,13 @@ plexiform layer using GABA. A protein that is a translation product of the human MYB gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx MYB - PRO:DNx + PRO:DNx @@ -196636,13 +197078,13 @@ plexiform layer using GABA. A protein that is a translation product of the human NETO1 gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx NETO1 - PRO:DNx + PRO:DNx @@ -196676,13 +197118,13 @@ plexiform layer using GABA. A transcription factor NF-kappa-B subunit that is a translation product of the human NFKB2 gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx NFKB2 - PRO:DNx + PRO:DNx @@ -196713,13 +197155,13 @@ plexiform layer using GABA. A protein that is a translation product of the human NTNG1 gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx NTNG1 - PRO:DNx + PRO:DNx @@ -196762,13 +197204,13 @@ plexiform layer using GABA. A protein that is a translation product of the human PRG2 gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx PRG2 - PRO:DNx + PRO:DNx @@ -196802,13 +197244,13 @@ plexiform layer using GABA. A protein that is a translation product of the human PVALB gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx PVALB - PRO:DNx + PRO:DNx @@ -196845,13 +197287,13 @@ plexiform layer using GABA. A protein that is a translation product of the human RNASE2 gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx RNASE2 - PRO:DNx + PRO:DNx @@ -196888,13 +197330,13 @@ plexiform layer using GABA. A protein that is a translation product of the human RNASE3 gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx RNASE3 - PRO:DNx + PRO:DNx @@ -196933,13 +197375,13 @@ plexiform layer using GABA. A protein that is a translation product of the human RUNX1 gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx RUNX1 - PRO:DNx + PRO:DNx @@ -196985,13 +197427,13 @@ plexiform layer using GABA. A protein that is a translation product of the human SNCG gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx SNCG - PRO:DNx + PRO:DNx @@ -197032,13 +197474,13 @@ plexiform layer using GABA. A protein that is a translation product of the human SST gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx SST - PRO:DNx + PRO:DNx @@ -197073,13 +197515,13 @@ plexiform layer using GABA. A protein that is a translation product of the human TAL1 gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx TAL1 - PRO:DNx + PRO:DNx @@ -197124,13 +197566,13 @@ plexiform layer using GABA. A protein that is a translation product of the human TMED1 gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx TMED1 - PRO:DNx + PRO:DNx @@ -197166,26 +197608,26 @@ plexiform layer using GABA. A protein that is a translation product of the human VIP gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx VIP - PRO:DNx + PRO:DNx vasoactive intestinal peptides - PRO:DNx + PRO:DNx vasoactive intestinal polypeptides - PRO:DNx + PRO:DNx @@ -197212,20 +197654,20 @@ plexiform layer using GABA. An organic amino compound that consists of amino acid residues (unmodified amino-acid residues and/or modified amino-acid residues) linked by peptide bonds or derivatives of such bonds. - PRO:DAN + PRO:DAN PRO:JSG peptide - PRO:DAN + PRO:DAN polypeptide - PRO:DAN + PRO:DAN @@ -197262,13 +197704,13 @@ plexiform layer using GABA. A CD19 molecule that has had the signal peptide removed. - PRO:DNx + PRO:DNx CD19/SigPep- - PRO:DNx + PRO:DNx @@ -197306,13 +197748,13 @@ plexiform layer using GABA. A CD34 molecule that has had the signal peptide removed. - PRO:DNx + PRO:DNx CD34/SigPep- - PRO:DNx + PRO:DNx @@ -197350,13 +197792,13 @@ plexiform layer using GABA. A CD4 molecule that has had the signal peptide removed. - PRO:DNx + PRO:DNx CD4/SigPep- - PRO:DNx + PRO:DNx @@ -197394,13 +197836,13 @@ plexiform layer using GABA. A receptor-type tyrosine-protein phosphatase C that has had the signal peptide removed. - PRO:DNx + PRO:DNx PTPRC/SigPep- - PRO:DNx + PRO:DNx @@ -197438,13 +197880,13 @@ plexiform layer using GABA. An integrin alpha-2 that has had the signal peptide removed. - PRO:DNx + PRO:DNx ITGA2/SigPep- - PRO:DNx + PRO:DNx @@ -197482,13 +197924,13 @@ plexiform layer using GABA. An integrin alpha-E that has had the signal peptide removed. - PRO:DNx + PRO:DNx ITGAE/SigPep- - PRO:DNx + PRO:DNx @@ -197526,13 +197968,13 @@ plexiform layer using GABA. An integrin alpha-M that has had the signal peptide removed. - PRO:DNx + PRO:DNx ITGAM/SigPep- - PRO:DNx + PRO:DNx @@ -197570,13 +198012,13 @@ plexiform layer using GABA. An integrin alpha-X that has had the signal peptide removed. - PRO:DNx + PRO:DNx ITGAX/SigPep- - PRO:DNx + PRO:DNx @@ -197614,13 +198056,13 @@ plexiform layer using GABA. A CD3 epsilon that has had the signal peptide removed. - PRO:DNx + PRO:DNx CD3E/SigPep- - PRO:DNx + PRO:DNx @@ -197658,13 +198100,13 @@ plexiform layer using GABA. A neural cell adhesion molecule 1 that has had the signal peptide removed. - PRO:DNx + PRO:DNx NCAM1/SigPep- - PRO:DNx + PRO:DNx @@ -197702,13 +198144,13 @@ plexiform layer using GABA. A lymphocyte antigen 75 that has had the signal peptide removed. - PRO:DNx + PRO:DNx LY75/SigPep- - PRO:DNx + PRO:DNx @@ -197746,13 +198188,13 @@ plexiform layer using GABA. A CD2 molecule that has had the signal peptide removed. - PRO:DNx + PRO:DNx CD2/SigPep- - PRO:DNx + PRO:DNx @@ -197790,13 +198232,13 @@ plexiform layer using GABA. A T-cell surface glycoprotein CD8 alpha chain that has had the signal peptide removed. - PRO:DNx + PRO:DNx CD8A/SigPep- - PRO:DNx + PRO:DNx @@ -197834,13 +198276,13 @@ plexiform layer using GABA. A T-cell surface glycoprotein CD8 beta chain that has had the signal peptide removed. - PRO:DNx + PRO:DNx CD8B/SigPep- - PRO:DNx + PRO:DNx @@ -197878,13 +198320,13 @@ plexiform layer using GABA. A CD48 molecule that has had the signal peptide removed. - PRO:DNx + PRO:DNx CD48/SigPep- - PRO:DNx + PRO:DNx @@ -197922,13 +198364,13 @@ plexiform layer using GABA. A CD83 molecule that has had the signal peptide removed. - PRO:DNx + PRO:DNx CD83/SigPep- - PRO:DNx + PRO:DNx @@ -197966,13 +198408,13 @@ plexiform layer using GABA. An L-selectin that has had the signal peptide removed. - PRO:DNx + PRO:DNx SELL/SigPep- - PRO:DNx + PRO:DNx @@ -198010,13 +198452,13 @@ plexiform layer using GABA. A SLAM family member 5 that has had the signal peptide removed. - PRO:DNx + PRO:DNx CD84/SigPep- - PRO:DNx + PRO:DNx @@ -198054,13 +198496,13 @@ plexiform layer using GABA. A carcinoembryonic antigen-related cell adhesion molecule 8 that has had the signal peptide removed. - PRO:DNx + PRO:DNx CEACAM8/SigPep- - PRO:DNx + PRO:DNx @@ -198098,13 +198540,13 @@ plexiform layer using GABA. A complement receptor type 1 that has had the signal peptide removed. - PRO:DNx + PRO:DNx CR1/SigPep- - PRO:DNx + PRO:DNx @@ -198142,13 +198584,13 @@ plexiform layer using GABA. A complement receptor type 2 that has had the signal peptide removed. - PRO:DNx + PRO:DNx CR2/SigPep- - PRO:DNx + PRO:DNx @@ -198186,13 +198628,13 @@ plexiform layer using GABA. An endoglin that has had the signal peptide removed. - PRO:DNx + PRO:DNx ENG/SigPep- - PRO:DNx + PRO:DNx @@ -198230,13 +198672,13 @@ plexiform layer using GABA. An interleukin-2 receptor subunit alpha that has had the signal peptide removed. - PRO:DNx + PRO:DNx IL2RA/SigPep- - PRO:DNx + PRO:DNx @@ -198274,13 +198716,13 @@ plexiform layer using GABA. An interleukin-2 receptor subunit beta that has had the signal peptide removed. - PRO:DNx + PRO:DNx IL2RB/SigPep- - PRO:DNx + PRO:DNx @@ -198318,13 +198760,13 @@ plexiform layer using GABA. A CD80 molecule that has had the signal peptide removed. - PRO:DNx + PRO:DNx CD80/SigPep- - PRO:DNx + PRO:DNx @@ -198362,13 +198804,13 @@ plexiform layer using GABA. A glycophorin-A that has had the signal peptide removed. - PRO:DNx + PRO:DNx GYPA/SigPep- - PRO:DNx + PRO:DNx @@ -198406,13 +198848,13 @@ plexiform layer using GABA. A high affinity immunoglobulin gamma Fc receptor I that has had the signal peptide removed. - PRO:DNx + PRO:DNx FCGR1A/SigPep- - PRO:DNx + PRO:DNx @@ -198450,13 +198892,13 @@ plexiform layer using GABA. A low affinity immunoglobulin gamma Fc region receptor II that has had the signal peptide removed. - PRO:DNx + PRO:DNx Fcgr2/SigPep- - PRO:DNx + PRO:DNx @@ -198494,13 +198936,13 @@ plexiform layer using GABA. A CD7 molecule that has had the signal peptide removed. - PRO:DNx + PRO:DNx CD7/SigPep- - PRO:DNx + PRO:DNx @@ -198538,13 +198980,13 @@ plexiform layer using GABA. A T-cell surface glycoprotein CD5 that has had the signal peptide removed. - PRO:DNx + PRO:DNx CD5/SigPep- - PRO:DNx + PRO:DNx @@ -198582,13 +199024,13 @@ plexiform layer using GABA. A T-cell-specific surface glycoprotein CD28 that has had the signal peptide removed. - PRO:DNx + PRO:DNx CD28/SigPep- - PRO:DNx + PRO:DNx @@ -198626,13 +199068,13 @@ plexiform layer using GABA. A Thy-1 membrane glycoprotein that has had the signal peptide removed. - PRO:DNx + PRO:DNx THY1/SigPep- - PRO:DNx + PRO:DNx @@ -198670,13 +199112,13 @@ plexiform layer using GABA. An interleukin-5 receptor subunit alpha that has had the signal peptide removed. - PRO:DNx + PRO:DNx IL5RA/SigPep- - PRO:DNx + PRO:DNx @@ -198714,13 +199156,13 @@ plexiform layer using GABA. An interleukin-7 receptor subunit alpha that has had the signal peptide removed. - PRO:DNx + PRO:DNx IL7R/SigPep- - PRO:DNx + PRO:DNx @@ -198758,13 +199200,13 @@ plexiform layer using GABA. A leukosialin that has had the signal peptide removed. - PRO:DNx + PRO:DNx SPN/SigPep- - PRO:DNx + PRO:DNx @@ -198802,13 +199244,13 @@ plexiform layer using GABA. A CD14 molecule that has had the signal peptide removed. - PRO:DNx + PRO:DNx CD14/SigPep- - PRO:DNx + PRO:DNx @@ -198846,13 +199288,13 @@ plexiform layer using GABA. A natural killer cell receptor 2B4 that has had the signal peptide removed. - PRO:DNx + PRO:DNx CD244/SigPep- - PRO:DNx + PRO:DNx @@ -198890,13 +199332,13 @@ plexiform layer using GABA. A platelet glycoprotein Ib alpha chain that has had the signal peptide removed. - PRO:DNx + PRO:DNx GP1BA/SigPep- - PRO:DNx + PRO:DNx @@ -198934,13 +199376,13 @@ plexiform layer using GABA. A sialoadhesin that has had the signal peptide removed. - PRO:DNx + PRO:DNx SIGLEC1/SigPep- - PRO:DNx + PRO:DNx @@ -198978,13 +199420,13 @@ plexiform layer using GABA. A signal transducer CD24 that has had the signal peptide removed. - PRO:DNx + PRO:DNx CD24/SigPep- - PRO:DNx + PRO:DNx @@ -199022,13 +199464,13 @@ plexiform layer using GABA. A tartrate-resistant acid phosphatase type 5 that has had the signal peptide removed. - PRO:DNx + PRO:DNx ACP5/SigPep- - PRO:DNx + PRO:DNx @@ -199066,13 +199508,13 @@ plexiform layer using GABA. A CD27 molecule that has had the signal peptide removed. - PRO:DNx + PRO:DNx CD27/SigPep- - PRO:DNx + PRO:DNx @@ -199110,13 +199552,13 @@ plexiform layer using GABA. A tyrosine-protein phosphatase non-receptor type substrate 1 that has had the signal peptide removed. - PRO:DNx + PRO:DNx SIRPA/SigPep- - PRO:DNx + PRO:DNx @@ -199154,13 +199596,13 @@ plexiform layer using GABA. A urokinase plasminogen activator surface receptor that has had the signal peptide removed. - PRO:DNx + PRO:DNx PLAUR/SigPep- - PRO:DNx + PRO:DNx @@ -199199,20 +199641,20 @@ plexiform layer using GABA. An MHC class II histocompatibility antigen alpha chain DRA that has had the signal peptide removed. - PRO:DNx + PRO:DNx MHCcIIalpha_DRA/SigPep- - PRO:DAN + PRO:DAN HLA-DRA/SigPep- - PRO:DNx + PRO:DNx @@ -199249,13 +199691,13 @@ plexiform layer using GABA. A T-cell surface glycoprotein CD1a that has had the signal peptide removed. - PRO:DNx + PRO:DNx CD1A/SigPep- - PRO:DNx + PRO:DNx @@ -199293,13 +199735,13 @@ plexiform layer using GABA. An antigen-presenting glycoprotein CD1d that has had the signal peptide removed. - PRO:DNx + PRO:DNx CD1D/SigPep- - PRO:DNx + PRO:DNx @@ -199337,13 +199779,13 @@ plexiform layer using GABA. An alpha-type platelet-derived growth factor receptor that has had the signal peptide removed. - PRO:DNx + PRO:DNx PDGFRA/SigPep- - PRO:DNx + PRO:DNx @@ -199381,13 +199823,13 @@ plexiform layer using GABA. A complement component C1q receptor that has had the signal peptide removed. - PRO:DNx + PRO:DNx CD93/SigPep- - PRO:DNx + PRO:DNx @@ -199425,13 +199867,13 @@ plexiform layer using GABA. A thrombomodulin that has had the signal peptide removed. - PRO:DNx + PRO:DNx THBD/SigPep- - PRO:DNx + PRO:DNx @@ -199469,13 +199911,13 @@ plexiform layer using GABA. A lymphocyte antigen 6A-2/6E-1 that has had the signal peptide removed. - PRO:DNx + PRO:DNx Ly6a/SigPep- - PRO:DNx + PRO:DNx @@ -199513,13 +199955,13 @@ plexiform layer using GABA. A lymphocyte antigen 6C2 that has had the signal peptide removed. - PRO:DNx + PRO:DNx Ly6c2/SigPep- - PRO:DNx + PRO:DNx @@ -199557,13 +199999,13 @@ plexiform layer using GABA. A collagen alpha-1(I) chain that has had the signal peptide removed. - PRO:DNx + PRO:DNx COL1A1/SigPep- - PRO:DNx + PRO:DNx @@ -199601,13 +200043,13 @@ plexiform layer using GABA. A perforin-1 that has had the signal peptide removed. - PRO:DNx + PRO:DNx PRF1/SigPep- - PRO:DNx + PRO:DNx @@ -199645,13 +200087,13 @@ plexiform layer using GABA. A cholecystokinin that has had the signal peptide removed. - PRO:DNx + PRO:DNx CCK/SigPep- - PRO:DNx + PRO:DNx @@ -199689,13 +200131,13 @@ plexiform layer using GABA. A high affinity immunoglobulin epsilon receptor subunit alpha that has had the signal peptide removed. - PRO:DNx + PRO:DNx FCER1A/SigPep- - PRO:DNx + PRO:DNx @@ -199733,13 +200175,13 @@ plexiform layer using GABA. An interleukin-17 receptor B that has had the signal peptide removed. - PRO:DNx + PRO:DNx IL17RB/SigPep- - PRO:DNx + PRO:DNx @@ -199777,13 +200219,13 @@ plexiform layer using GABA. An interleukin-1 receptor-like 1 that has had the signal peptide removed. - PRO:DNx + PRO:DNx IL1RL1/SigPep- - PRO:DNx + PRO:DNx @@ -199821,13 +200263,13 @@ plexiform layer using GABA. An integrin alpha-IIb that has had the signal peptide removed. - PRO:DNx + PRO:DNx ITGA2B/SigPep- - PRO:DNx + PRO:DNx @@ -199865,13 +200307,13 @@ plexiform layer using GABA. An integrin alpha-4 that has had the signal peptide removed. - PRO:DNx + PRO:DNx ITGA4/SigPep- - PRO:DNx + PRO:DNx @@ -199909,13 +200351,13 @@ plexiform layer using GABA. An integrin beta-7 that has had the signal peptide removed. - PRO:DNx + PRO:DNx ITGB7/SigPep- - PRO:DNx + PRO:DNx @@ -199953,13 +200395,13 @@ plexiform layer using GABA. A neutrophil gelatinase-associated lipocalin that has had the signal peptide removed. - PRO:DNx + PRO:DNx LCN2/SigPep- - PRO:DNx + PRO:DNx @@ -199997,13 +200439,13 @@ plexiform layer using GABA. A lactotransferrin that has had the signal peptide removed. - PRO:DNx + PRO:DNx LTF/SigPep- - PRO:DNx + PRO:DNx @@ -200041,13 +200483,13 @@ plexiform layer using GABA. A lumican that has had the signal peptide removed. - PRO:DNx + PRO:DNx LUM/SigPep- - PRO:DNx + PRO:DNx @@ -200085,13 +200527,13 @@ plexiform layer using GABA. A myeloperoxidase that has had the signal peptide removed. - PRO:DNx + PRO:DNx MPO/SigPep- - PRO:DNx + PRO:DNx @@ -200129,13 +200571,13 @@ plexiform layer using GABA. A netrin-G1 that has had the signal peptide removed. - PRO:DNx + PRO:DNx NTNG1/SigPep- - PRO:DNx + PRO:DNx @@ -200173,13 +200615,13 @@ plexiform layer using GABA. A bone marrow proteoglycan that has had the signal peptide removed. - PRO:DNx + PRO:DNx PRG2/SigPep- - PRO:DNx + PRO:DNx @@ -200217,13 +200659,13 @@ plexiform layer using GABA. A non-secretory ribonuclease that has had the signal peptide removed. - PRO:DNx + PRO:DNx RNASE2/SigPep- - PRO:DNx + PRO:DNx @@ -200261,13 +200703,13 @@ plexiform layer using GABA. An eosinophil cationic protein that has had the signal peptide removed. - PRO:DNx + PRO:DNx RNASE3/SigPep- - PRO:DNx + PRO:DNx @@ -200305,13 +200747,13 @@ plexiform layer using GABA. A somatostatin that has had the signal peptide removed. - PRO:DNx + PRO:DNx SST/SigPep- - PRO:DNx + PRO:DNx @@ -200337,7 +200779,7 @@ plexiform layer using GABA. A part of a protein that is removed during the protein maturation process. - PRO:DAN + PRO:DAN @@ -200363,13 +200805,13 @@ plexiform layer using GABA. A bone marrow proteoglycan that is a translation product of some mRNA giving rise to a protein with the amino acid sequence represented by UniProtKB:P13727-1 or a 1:1 ortholog thereof. - PRO:CNA + PRO:CNA PRG2/iso:1 - PRO:DNx + PRO:DNx @@ -200408,14 +200850,14 @@ plexiform layer using GABA. A bone marrow proteoglycan isoform 1, signal peptide removed form that has had the acidic propeptide removed. PMID:9657764 - PRO:CNA - PRO:DAN + PRO:CNA + PRO:DAN PRG2/iso:1/EMBP - PRO:DAN + PRO:DAN @@ -200451,7 +200893,7 @@ plexiform layer using GABA. A protein-containing complex that is a membrane-bound heterodimeric co-receptor for MHC class-I antigen/T-cell receptor interaction. PMID:18275828 PMID:3264320 - PRO:DAN + PRO:DAN @@ -200472,13 +200914,13 @@ plexiform layer using GABA. A T-cell surface glycoprotein CD8 alpha chain that is a translation product of some mRNA giving rise to a protein with the amino acid sequence represented by UniProtKB:P01732-1 or a 1:1 ortholog thereof. Having a single-pass transmembrane domain, this form is membrane bound. - PRO:DAN + PRO:DAN CD8A/iso:1 - PRO:DNx + PRO:DNx @@ -200500,13 +200942,13 @@ plexiform layer using GABA. A T-cell surface glycoprotein CD8 beta chain that is a translation product of some mRNA giving rise to a protein with the amino acid sequence represented by UniProtKB:P10966-1 or a 1:1 ortholog thereof. - PRO:DAN + PRO:DAN CD8B/iso:1 - PRO:DNx + PRO:DNx @@ -200545,13 +200987,13 @@ plexiform layer using GABA. A T-cell surface glycoprotein CD8 alpha chain isoform 1 that has had the signal peptide removed to yield the mature form. - PRO:DAN + PRO:DAN CD8A/iso:1/SigPep- - PRO:DNx + PRO:DNx @@ -200584,13 +201026,13 @@ plexiform layer using GABA. A T-cell surface glycoprotein CD8 beta chain isoform 1 that has had the signal peptide removed to yield the mature form. - PRO:DAN + PRO:DAN CD8B/iso:1/SigPep- - PRO:DNx + PRO:DNx @@ -200623,13 +201065,13 @@ plexiform layer using GABA. A T-cell surface glycoprotein CD8 alpha chain isoform 1, signal peptide removed form that includes at least one glycosylated residue. - PRO:DAN + PRO:DAN CD8A/iso:1/SigPep-/GlycoRes+ - PRO:DNx + PRO:DNx @@ -200662,13 +201104,13 @@ plexiform layer using GABA. A T-cell surface glycoprotein CD8 beta chain isoform 1, signal peptide removed form that includes at least one glycosylated residue. - PRO:DAN + PRO:DAN CD8B/iso:1/SigPep-/GlycoRes+ - PRO:DNx + PRO:DNx @@ -200701,13 +201143,13 @@ plexiform layer using GABA. A bone marrow proteoglycan isoform 1 that has had the signal peptide removed. - PRO:DAN + PRO:DAN PRG2/iso:1/SigPep- - PRO:DNx + PRO:DNx @@ -200729,20 +201171,20 @@ plexiform layer using GABA. An organic group that results from covalent modification or chemical alteration to the side chain or backbone atoms of an amino acid residue or derivative thereof, where such alteration maintains the integrity of the amino acid chain containing the residue. - PRO:DAN + PRO:DAN PRO:JSG modified amino acid chain residue - PRO:DAN + PRO:DAN modified protein residue - PRO:DAN + PRO:DAN @@ -200770,19 +201212,19 @@ plexiform layer using GABA. A KLRB1-like protein that is a translation product of the human KLRB1 gene or a 1:1 ortholog thereof. - PRO:DAN + PRO:DAN NKR-P1A - PRO:DNx + PRO:DNx KLRB1 - PRO:DNx + PRO:DNx @@ -200834,7 +201276,7 @@ plexiform layer using GABA. An integrin alpha that lacks an A domain. This type of integrin is often cleaved into heavy and light chains. - PRO:DAN + PRO:DAN @@ -200866,13 +201308,13 @@ plexiform layer using GABA. A receptor-type tyrosine-protein phosphatase C isoform CD45RABC that has had the signal peptide removed. - PRO:DAN + PRO:DAN PTPRC/iso:CD45RABC/SigPep- - PRO:DNx + PRO:DNx @@ -200906,13 +201348,13 @@ plexiform layer using GABA. A receptor-type tyrosine-protein phosphatase C isoform CD45RA that has had the signal peptide removed. PMID:1351092 - PRO:CNA + PRO:CNA PTPRC/iso:CD45RA/SigPep- - PRO:DNx + PRO:DNx @@ -200945,13 +201387,13 @@ plexiform layer using GABA. A receptor-type tyrosine-protein phosphatase C isoform CD45RO that has had the signal peptide removed. - PRO:DAN + PRO:DAN PTPRC/iso:CD45RO/SigPep- - PRO:DNx + PRO:DNx @@ -200985,13 +201427,13 @@ plexiform layer using GABA. A receptor-type tyrosine-protein phosphatase C isoform CD45RABC, signal peptide removed form that includes at least one glycosylated residue. - PRO:DAN + PRO:DAN PTPRC/iso:CD45R/SigPep-/GlycoRes+ - PRO:DNx + PRO:DNx @@ -201025,13 +201467,13 @@ plexiform layer using GABA. A receptor-type tyrosine-protein phosphatase C isoform CD45RA, signal peptide removed form that includes at least one glycosylated residue. PMID:1351092 - PRO:CNA + PRO:CNA PTPRC/iso:CD45RA/SigPep-/GlycoRes+ - PRO:DNx + PRO:DNx @@ -201065,19 +201507,19 @@ plexiform layer using GABA. A receptor-type tyrosine-protein phosphatase C isoform CD45RO, signal peptide removed form that includes at least one glycosylated residue. - PRO:DAN + PRO:DAN T200 - PRO:DNx + PRO:DNx PTPRC/iso:CD45RO/SigPep-/GlycoRes+ - PRO:DNx + PRO:DNx @@ -201115,13 +201557,13 @@ plexiform layer using GABA. A transmembrane emp24 domain-containing protein 1 that has had the signal peptide removed. - PRO:DNx + PRO:DNx TMED1/SigPep- - PRO:DNx + PRO:DNx @@ -201159,13 +201601,13 @@ plexiform layer using GABA. A granzyme B that has had the signal peptide removed. - PRO:DNx + PRO:DNx GZMB/SigPep- - PRO:DNx + PRO:DNx @@ -201201,7 +201643,7 @@ plexiform layer using GABA. An integrin alpha-E, signal peptide removed form in human. UniProtKB:P38570, 19-1179. - PRO:CNA + PRO:CNA Reactome:R-HSA-265403 @@ -201214,21 +201656,21 @@ plexiform layer using GABA. PRO_0000016283 - PRO:DNx + PRO:DNx UniProtKB:P38570, 19-1179 - PRO:DNx + PRO:DNx hITGAE/SigPep- - PRO:DNx + PRO:DNx @@ -201265,7 +201707,7 @@ plexiform layer using GABA. A T-cell-specific surface glycoprotein CD28, signal peptide removed form in human. Example: UniProtKB:P10747-1, 19-220. - PRO:CNA + PRO:CNA Reactome:R-HSA-167628 Reactome:R-HSA-167632 @@ -201285,21 +201727,21 @@ plexiform layer using GABA. hCD28/SigPep- - PRO:DNx + PRO:DNx PRO_0000014652 - PRO:DNx + PRO:DNx UniProtKB:P10747-1, 19-220 - PRO:DNx + PRO:DNx @@ -201337,7 +201779,7 @@ plexiform layer using GABA. An integrin alpha-M, signal peptide removed form in human. Example: UniProtKB:P11215-1, 17-1152. - PRO:DNx + PRO:DNx @@ -201361,21 +201803,21 @@ plexiform layer using GABA. hITGAM/SigPep- - PRO:DNx + PRO:DNx PRO_0000016289 - PRO:DNx + PRO:DNx UniProtKB:P11215-1, 17-1152 - PRO:DNx + PRO:DNx @@ -201411,7 +201853,7 @@ plexiform layer using GABA. An integrin alpha-IIb, signal peptide removed form in human. Example: UniProtKB:P08514-1, 32-1039. - PRO:DNx + PRO:DNx @@ -201423,21 +201865,21 @@ plexiform layer using GABA. hITGA2B/SigPep- - PRO:DNx + PRO:DNx PRO_0000016276 - PRO:DNx + PRO:DNx UniProtKB:P08514-1, 32-1039 - PRO:DNx + PRO:DNx @@ -201476,7 +201918,7 @@ plexiform layer using GABA. A CD4 molecule, signal peptide removed form in human. UniProtKB:P01730, 26-458. - PRO:DNx + PRO:DNx @@ -201506,21 +201948,21 @@ plexiform layer using GABA. PRO_0000014621 - PRO:DNx + PRO:DNx UniProtKB:P01730, 26-458 - PRO:DNx + PRO:DNx hCD4/SigPep- - PRO:DNx + PRO:DNx @@ -201557,13 +201999,13 @@ plexiform layer using GABA. A protein that is encoded in the genome of Mus musculus. - PRO:DAN + PRO:DAN mouse protein - PRO:DAN + PRO:DAN @@ -201600,13 +202042,13 @@ plexiform layer using GABA. A protein that is encoded in the genome of Homo sapiens. - PRO:DAN + PRO:DAN human protein - PRO:DAN + PRO:DAN @@ -201631,13 +202073,13 @@ plexiform layer using GABA. A protein that is a translation product of the human IRX6 gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx IRX6 - PRO:DNx + PRO:DNx @@ -201691,7 +202133,7 @@ plexiform layer using GABA. A protein that has G protein-coupled receptor (GPCR) activity. Each GPCR consists of a single polypeptide with an extracellular N-terminus, an intracellular C-terminus and seven hydrophobic transmembrane domains (TM1-TM7) linked by three extracellular loops (ECL1-ECL3) and three intracellular loops (ICL1-ICL3). GPCRs function as part of a heterotrimeric complex to transmit an extracellular signal across the membrane by activating an associated G-protein via the exchange of GDP for GTP on the alpha subunit. IUPHARfam:694 - PRO:DAN + PRO:DAN Wikipedia:GPCR @@ -201710,7 +202152,7 @@ plexiform layer using GABA. fam:GPCR - PRO:DAN + PRO:DAN @@ -201737,13 +202179,13 @@ plexiform layer using GABA. A protein that is a translation product of the human LAMP5 gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx LAMP5 - PRO:DNx + PRO:DNx @@ -201794,7 +202236,7 @@ plexiform layer using GABA. A lymphocyte antigen 75 that is encoded in the genome of human. - PRO:DAN + PRO:DAN UniProtKB:O60449 @@ -201831,7 +202273,7 @@ plexiform layer using GABA. hLY75 - PRO:DNx + PRO:DNx @@ -201874,13 +202316,13 @@ plexiform layer using GABA. A protein that is encoded in the genome of some Eukaryota. - PRO:DAN + PRO:DAN Eukaryota protein - PRO:DAN + PRO:DAN @@ -201914,7 +202356,7 @@ plexiform layer using GABA. A T-cell surface glycoprotein CD1 that is encoded in the genome of human. - PRO:DAN + PRO:DAN @@ -201926,7 +202368,7 @@ plexiform layer using GABA. hCD1 - PRO:DAN + PRO:DAN @@ -201966,26 +202408,26 @@ plexiform layer using GABA. A protein that includes at least one glycosylated residue. - PRO:DAN + PRO:DAN Prot/GlycoRes+ - PRO:DAN + PRO:DAN glycated protein - PRO:DAN + PRO:DAN glycosylated protein - PRO:DAN + PRO:DAN @@ -202012,20 +202454,20 @@ plexiform layer using GABA. A protein that is a translation product of some metazoan gene that encodes a signal peptide followed by a single Cathepsin propeptide inhibitor domain (Pfam:PF08246) followed by a single Papain family cysteine protease (Pfam:PF00112) domain at the C terminus. - PRO:DAN + PRO:DAN fam:CTS - PRO:DNx + PRO:DNx cathepsin - PRO:DAN + PRO:DAN @@ -202062,13 +202504,13 @@ plexiform layer using GABA. A neuronal acetylcholine receptor subunit alpha-7 that has had the signal peptide removed. - PRO:DAN + PRO:DAN CHRNA7/SigPep- - PRO:DAN + PRO:DAN @@ -202104,7 +202546,7 @@ plexiform layer using GABA. A neuronal acetylcholine receptor subunit alpha-7, signal peptide removed form in human. Example: UniProtKB:P36544-1, 23-502. - PRO:DAN + PRO:DAN @@ -202116,21 +202558,21 @@ plexiform layer using GABA. hCHRNA7/SigPep- - PRO:DAN + PRO:DAN PRO_0000000366 - PRO:DNx + PRO:DNx UniProtKB:P36544-1, 23-502 - PRO:DNx + PRO:DNx @@ -202176,7 +202618,7 @@ plexiform layer using GABA. fam:vgate_ion_chan - PRO:DAN + PRO:DAN @@ -202204,7 +202646,7 @@ plexiform layer using GABA. fam:TRP_chan - PRO:DAN + PRO:DAN @@ -202331,7 +202773,7 @@ plexiform layer using GABA. fam:chan - PRO:DAN + PRO:DAN @@ -202369,7 +202811,7 @@ plexiform layer using GABA. fam:LILR - PRO:DAN + PRO:DAN @@ -202405,7 +202847,7 @@ plexiform layer using GABA. A tartrate-resistant acid phosphatase type 5 (human) that has had the signal peptide removed. UniProtKB:P13686, 22-325. - PRO:DNx + PRO:DNx Reactome:R-HSA-196938 @@ -202418,21 +202860,21 @@ plexiform layer using GABA. PRO_0000023981 - PRO:DNx + PRO:DNx UniProtKB:P13686, 22-325 - PRO:DNx + PRO:DNx hACP5/SigPep- - PRO:DNx + PRO:DNx @@ -202468,7 +202910,7 @@ plexiform layer using GABA. A cholecystokinin (human) that has had the signal peptide removed. UniProtKB:P06307, 21-115. - PRO:DNx + PRO:DNx Reactome:R-HSA-388539 @@ -202481,21 +202923,21 @@ plexiform layer using GABA. PRO_0000010536 - PRO:DNx + PRO:DNx UniProtKB:P06307, 21-115 - PRO:DNx + PRO:DNx hCCK/SigPep- - PRO:DNx + PRO:DNx @@ -202536,7 +202978,7 @@ plexiform layer using GABA. A C-C chemokine receptor type 7 (human) that has had the signal peptide removed. UniProtKB:P32248, 25-378. - PRO:DNx + PRO:DNx Reactome:R-HSA-373125 @@ -202549,21 +202991,21 @@ plexiform layer using GABA. PRO_0000012735 - PRO:DNx + PRO:DNx UniProtKB:P32248, 25-378 - PRO:DNx + PRO:DNx hCCR7/SigPep- - PRO:DNx + PRO:DNx @@ -202605,7 +203047,7 @@ plexiform layer using GABA. A scavenger receptor cysteine-rich type 1 protein M130 (human) that has had the signal peptide removed. UniProtKB:Q86VB7, 42-1156. - PRO:DNx + PRO:DNx Reactome:R-HSA-2168868 Reactome:R-HSA-2230974 @@ -202625,21 +203067,21 @@ plexiform layer using GABA. PRO_0000238938 - PRO:DNx + PRO:DNx UniProtKB:Q86VB7, 42-1156 - PRO:DNx + PRO:DNx hCD163/SigPep- - PRO:DNx + PRO:DNx @@ -202675,7 +203117,7 @@ plexiform layer using GABA. A B-lymphocyte antigen CD19 (human) that has had the signal peptide removed. UniProtKB:P15391, 20-556. - PRO:DNx + PRO:DNx Reactome:R-HSA-197740 @@ -202688,21 +203130,21 @@ plexiform layer using GABA. PRO_0000014648 - PRO:DNx + PRO:DNx UniProtKB:P15391, 20-556 - PRO:DNx + PRO:DNx hCD19/SigPep- - PRO:DNx + PRO:DNx @@ -202738,7 +203180,7 @@ plexiform layer using GABA. A T-cell surface glycoprotein CD1a (human) that has had the signal peptide removed. UniProtKB:P06126, 17-327. - PRO:DNx + PRO:DNx Reactome:R-HSA-197792 @@ -202751,21 +203193,21 @@ plexiform layer using GABA. PRO_0000014578 - PRO:DNx + PRO:DNx UniProtKB:P06126, 17-327 - PRO:DNx + PRO:DNx hCD1A/SigPep- - PRO:DNx + PRO:DNx @@ -202806,7 +203248,7 @@ plexiform layer using GABA. A T-cell surface glycoprotein CD1c (human) that has had the signal peptide removed. UniProtKB:P29017, 18-333. - PRO:DNx + PRO:DNx Reactome:R-HSA-8850110 @@ -202819,21 +203261,21 @@ plexiform layer using GABA. PRO_0000014580 - PRO:DNx + PRO:DNx UniProtKB:P29017, 18-333 - PRO:DNx + PRO:DNx hCD1C/SigPep- - PRO:DNx + PRO:DNx @@ -202869,7 +203311,7 @@ plexiform layer using GABA. An antigen-presenting glycoprotein CD1d (human) that has had the signal peptide removed. UniProtKB:P15813, 20-335. - PRO:DNx + PRO:DNx Reactome:R-HSA-197833 @@ -202882,21 +203324,21 @@ plexiform layer using GABA. PRO_0000014581 - PRO:DNx + PRO:DNx UniProtKB:P15813, 20-335 - PRO:DNx + PRO:DNx hCD1D/SigPep- - PRO:DNx + PRO:DNx @@ -202932,7 +203374,7 @@ plexiform layer using GABA. A T-cell surface antigen CD2 (human) that has had the signal peptide removed. UniProtKB:P06729, 25-351. - PRO:DNx + PRO:DNx Reactome:R-HSA-197795 @@ -202945,21 +203387,21 @@ plexiform layer using GABA. PRO_0000014600 - PRO:DNx + PRO:DNx UniProtKB:P06729, 25-351 - PRO:DNx + PRO:DNx hCD2/SigPep- - PRO:DNx + PRO:DNx @@ -203000,7 +203442,7 @@ plexiform layer using GABA. A B-cell receptor CD22 (human) that has had the signal peptide removed. UniProtKB:P20273, 20-847. - PRO:DNx + PRO:DNx Reactome:R-HSA-197703 @@ -203013,21 +203455,21 @@ plexiform layer using GABA. PRO_0000014873 - PRO:DNx + PRO:DNx UniProtKB:P20273, 20-847 - PRO:DNx + PRO:DNx hCD22/SigPep- - PRO:DNx + PRO:DNx @@ -203063,7 +203505,7 @@ plexiform layer using GABA. A natural killer cell receptor 2B4 (human) that has had the signal peptide removed. UniProtKB:Q9BZW8, 22-370. - PRO:DNx + PRO:DNx Reactome:R-HSA-197846 @@ -203076,21 +203518,21 @@ plexiform layer using GABA. PRO_0000014668 - PRO:DNx + PRO:DNx UniProtKB:Q9BZW8, 22-370 - PRO:DNx + PRO:DNx hCD244/SigPep- - PRO:DNx + PRO:DNx @@ -203126,7 +203568,7 @@ plexiform layer using GABA. A CD27 antigen (human) that has had the signal peptide removed. UniProtKB:P26842, 20-260. - PRO:DNx + PRO:DNx Reactome:R-HSA-5666994 @@ -203139,21 +203581,21 @@ plexiform layer using GABA. PRO_0000034571 - PRO:DNx + PRO:DNx UniProtKB:P26842, 20-260 - PRO:DNx + PRO:DNx hCD27/SigPep- - PRO:DNx + PRO:DNx @@ -203196,7 +203638,7 @@ plexiform layer using GABA. A myeloid cell surface antigen CD33 (human) that has had the signal peptide removed. UniProtKB:P20138, 18-364. - PRO:DNx + PRO:DNx Reactome:R-HSA-197719 @@ -203221,21 +203663,21 @@ plexiform layer using GABA. PRO_0000014878 - PRO:DNx + PRO:DNx UniProtKB:P20138, 18-364 - PRO:DNx + PRO:DNx hCD33/SigPep- - PRO:DNx + PRO:DNx @@ -203271,7 +203713,7 @@ plexiform layer using GABA. A T-cell surface glycoprotein CD3 epsilon chain (human) that has had the signal peptide removed. UniProtKB:P07766, 23-207. - PRO:DNx + PRO:DNx Reactome:R-HSA-197906 @@ -203284,21 +203726,21 @@ plexiform layer using GABA. PRO_0000014607 - PRO:DNx + PRO:DNx UniProtKB:P07766, 23-207 - PRO:DNx + PRO:DNx hCD3E/SigPep- - PRO:DNx + PRO:DNx @@ -203340,7 +203782,7 @@ plexiform layer using GABA. A CD44 antigen (human) that has had the signal peptide removed. UniProtKB:P16070, 21-742. - PRO:DNx + PRO:DNx Reactome:R-HSA-1031688 @@ -203359,21 +203801,21 @@ plexiform layer using GABA. PRO_0000026687 - PRO:DNx + PRO:DNx UniProtKB:P16070, 21-742 - PRO:DNx + PRO:DNx hCD44/SigPep- - PRO:DNx + PRO:DNx @@ -203409,7 +203851,7 @@ plexiform layer using GABA. A T-lymphocyte activation antigen CD80 (human) that has had the signal peptide removed. UniProtKB:P33681, 35-288. - PRO:DNx + PRO:DNx Reactome:R-HSA-179789 @@ -203422,21 +203864,21 @@ plexiform layer using GABA. PRO_0000014547 - PRO:DNx + PRO:DNx UniProtKB:P33681, 35-288 - PRO:DNx + PRO:DNx hCD80/SigPep- - PRO:DNx + PRO:DNx @@ -203472,7 +203914,7 @@ plexiform layer using GABA. A SLAM family member 5 (human) that has had the signal peptide removed. UniProtKB:Q9UIB8, 22-345. - PRO:DNx + PRO:DNx Reactome:R-HSA-3325587 @@ -203485,21 +203927,21 @@ plexiform layer using GABA. PRO_0000252029 - PRO:DNx + PRO:DNx UniProtKB:Q9UIB8, 22-345 - PRO:DNx + PRO:DNx hCD84/SigPep- - PRO:DNx + PRO:DNx @@ -203540,7 +203982,7 @@ plexiform layer using GABA. A T-lymphocyte activation antigen CD86 (human) that has had the signal peptide removed. UniProtKB:P42081, 24-329. - PRO:DNx + PRO:DNx Reactome:R-HSA-179784 @@ -203553,21 +203995,21 @@ plexiform layer using GABA. PRO_0000014550 - PRO:DNx + PRO:DNx UniProtKB:P42081, 24-329 - PRO:DNx + PRO:DNx hCD86/SigPep- - PRO:DNx + PRO:DNx @@ -203603,7 +204045,7 @@ plexiform layer using GABA. A T-cell surface glycoprotein CD8 alpha chain (human) that has had the signal peptide removed. UniProtKB:P01732, 22-235. - PRO:DNx + PRO:DNx Reactome:R-HSA-197601 @@ -203616,21 +204058,21 @@ plexiform layer using GABA. PRO_0000014638 - PRO:DNx + PRO:DNx UniProtKB:P01732, 22-235 - PRO:DNx + PRO:DNx hCD8A/SigPep- - PRO:DNx + PRO:DNx @@ -203667,7 +204109,7 @@ plexiform layer using GABA. A T-cell surface glycoprotein CD8 beta chain (human) that has had the signal peptide removed. UniProtKB:P10966, 22-210. - PRO:DNx + PRO:DNx Reactome:R-HSA-2980537 Reactome:R-HSA-3149571 @@ -203687,21 +204129,21 @@ plexiform layer using GABA. PRO_0000014643 - PRO:DNx + PRO:DNx UniProtKB:P10966, 22-210 - PRO:DNx + PRO:DNx hCD8B/SigPep- - PRO:DNx + PRO:DNx @@ -203737,7 +204179,7 @@ plexiform layer using GABA. A collagen alpha-1(I) chain (human) that has had the signal peptide removed. UniProtKB:P02452, 23-1464. - PRO:DNx + PRO:DNx Reactome:R-HSA-1650777 Reactome:R-HSA-2268635 @@ -203757,14 +204199,14 @@ plexiform layer using GABA. UniProtKB:P02452, 23-1464 - PRO:DNx + PRO:DNx hCOL1A1/SigPep- - PRO:DNx + PRO:DNx @@ -203802,7 +204244,7 @@ plexiform layer using GABA. A complement receptor type 1 (human) that has had the signal peptide removed. UniProtKB:P17927, 42-2039. - PRO:DNx + PRO:DNx Reactome:R-HSA-977369 @@ -203827,21 +204269,21 @@ plexiform layer using GABA. PRO_0000006009 - PRO:DNx + PRO:DNx UniProtKB:P17927, 42-2039 - PRO:DNx + PRO:DNx hCR1/SigPep- - PRO:DNx + PRO:DNx @@ -203882,7 +204324,7 @@ plexiform layer using GABA. A macrophage colony-stimulating factor 1 receptor (human) that has had the signal peptide removed. UniProtKB:P07333, 20-972. - PRO:DNx + PRO:DNx Reactome:R-HSA-197667 @@ -203895,21 +204337,21 @@ plexiform layer using GABA. PRO_0000016765 - PRO:DNx + PRO:DNx UniProtKB:P07333, 20-972 - PRO:DNx + PRO:DNx hCSF1R/SigPep- - PRO:DNx + PRO:DNx @@ -203950,7 +204392,7 @@ plexiform layer using GABA. A cytotoxic T-lymphocyte protein 4 (human) that has had the signal peptide removed. UniProtKB:P16410, 36-223. - PRO:DNx + PRO:DNx Reactome:R-HSA-179764 @@ -203963,21 +204405,21 @@ plexiform layer using GABA. PRO_0000014734 - PRO:DNx + PRO:DNx UniProtKB:P16410, 36-223 - PRO:DNx + PRO:DNx hCTLA4/SigPep- - PRO:DNx + PRO:DNx @@ -204013,7 +204455,7 @@ plexiform layer using GABA. A high affinity immunoglobulin epsilon receptor subunit alpha (human) that has had the signal peptide removed. UniProtKB:P12319, 26-257. - PRO:DNx + PRO:DNx Reactome:R-HSA-197802 @@ -204026,21 +204468,21 @@ plexiform layer using GABA. PRO_0000015161 - PRO:DNx + PRO:DNx UniProtKB:P12319, 26-257 - PRO:DNx + PRO:DNx hFCER1A/SigPep- - PRO:DNx + PRO:DNx @@ -204078,7 +204520,7 @@ plexiform layer using GABA. A high affinity immunoglobulin gamma Fc receptor I (human) that has had the signal peptide removed. UniProtKB:P12314, 16-374. - PRO:DNx + PRO:DNx Reactome:R-HSA-1236781 Reactome:R-HSA-1236890 Reactome:R-HSA-197835 @@ -204105,21 +204547,21 @@ plexiform layer using GABA. PRO_0000015139 - PRO:DNx + PRO:DNx UniProtKB:P12314, 16-374 - PRO:DNx + PRO:DNx hFCGR1A/SigPep- - PRO:DNx + PRO:DNx @@ -204160,7 +204602,7 @@ plexiform layer using GABA. A low affinity immunoglobulin gamma Fc region receptor II-b (human) that has had the signal peptide removed. UniProtKB:P31994, 43-310. - PRO:DNx + PRO:DNx Reactome:R-HSA-197854 @@ -204173,21 +204615,21 @@ plexiform layer using GABA. PRO_0000015147 - PRO:DNx + PRO:DNx UniProtKB:P31994, 43-310 - PRO:DNx + PRO:DNx hFCGR2B/SigPep- - PRO:DNx + PRO:DNx @@ -204228,7 +204670,7 @@ plexiform layer using GABA. A receptor-type tyrosine-protein kinase FLT3 (human) that has had the signal peptide removed. UniProtKB:P36888, 27-993. - PRO:DNx + PRO:DNx Reactome:R-HSA-6786756 @@ -204241,21 +204683,21 @@ plexiform layer using GABA. PRO_0000016778 - PRO:DNx + PRO:DNx UniProtKB:P36888, 27-993 - PRO:DNx + PRO:DNx hFLT3/SigPep- - PRO:DNx + PRO:DNx @@ -204291,7 +204733,7 @@ plexiform layer using GABA. An interleukin-17 receptor B (human) that has had the signal peptide removed. UniProtKB:Q9NRM6, 18-502. - PRO:DNx + PRO:DNx Reactome:R-HSA-447257 @@ -204304,21 +204746,21 @@ plexiform layer using GABA. PRO_0000011032 - PRO:DNx + PRO:DNx UniProtKB:Q9NRM6, 18-502 - PRO:DNx + PRO:DNx hIL17RB/SigPep- - PRO:DNx + PRO:DNx @@ -204355,7 +204797,7 @@ plexiform layer using GABA. An interleukin-1 receptor-like 1 (human) that has had the signal peptide removed. UniProtKB:Q01638, 19-556. - PRO:DNx + PRO:DNx Reactome:R-HSA-197594 @@ -204374,21 +204816,21 @@ plexiform layer using GABA. PRO_0000015442 - PRO:DNx + PRO:DNx UniProtKB:Q01638, 19-556 - PRO:DNx + PRO:DNx hIL1RL1/SigPep- - PRO:DNx + PRO:DNx @@ -204424,7 +204866,7 @@ plexiform layer using GABA. An interleukin-2 receptor subunit alpha (human) that has had the signal peptide removed. UniProtKB:P01589, 22-272. - PRO:DNx + PRO:DNx Reactome:R-HSA-450046 @@ -204437,21 +204879,21 @@ plexiform layer using GABA. PRO_0000011024 - PRO:DNx + PRO:DNx UniProtKB:P01589, 22-272 - PRO:DNx + PRO:DNx hIL2RA/SigPep- - PRO:DNx + PRO:DNx @@ -204488,7 +204930,7 @@ plexiform layer using GABA. An interleukin-2 receptor subunit beta (human) that has had the signal peptide removed. UniProtKB:P14784, 27-551. - PRO:DNx + PRO:DNx Reactome:R-HSA-197876 @@ -204507,21 +204949,21 @@ plexiform layer using GABA. PRO_0000010878 - PRO:DNx + PRO:DNx UniProtKB:P14784, 27-551 - PRO:DNx + PRO:DNx hIL2RB/SigPep- - PRO:DNx + PRO:DNx @@ -204562,7 +205004,7 @@ plexiform layer using GABA. An interleukin-3 receptor subunit alpha (human) that has had the signal peptide removed. UniProtKB:P26951, 19-378. - PRO:DNx + PRO:DNx Reactome:R-HSA-879938 @@ -204575,21 +205017,21 @@ plexiform layer using GABA. PRO_0000010883 - PRO:DNx + PRO:DNx UniProtKB:P26951, 19-378 - PRO:DNx + PRO:DNx hIL3RA/SigPep- - PRO:DNx + PRO:DNx @@ -204625,7 +205067,7 @@ plexiform layer using GABA. An interleukin-5 receptor subunit alpha (human) that has had the signal peptide removed. UniProtKB:Q01344, 21-420. - PRO:DNx + PRO:DNx Reactome:R-HSA-450072 @@ -204638,21 +205080,21 @@ plexiform layer using GABA. PRO_0000010893 - PRO:DNx + PRO:DNx UniProtKB:Q01344, 21-420 - PRO:DNx + PRO:DNx hIL5RA/SigPep- - PRO:DNx + PRO:DNx @@ -204689,7 +205131,7 @@ plexiform layer using GABA. An interleukin-7 receptor subunit alpha (human) that has had the signal peptide removed. UniProtKB:P16871, 21-459. - PRO:DNx + PRO:DNx Reactome:R-HSA-449945 @@ -204708,21 +205150,21 @@ plexiform layer using GABA. PRO_0000010909 - PRO:DNx + PRO:DNx UniProtKB:P16871, 21-459 - PRO:DNx + PRO:DNx hIL7R/SigPep- - PRO:DNx + PRO:DNx @@ -204758,7 +205200,7 @@ plexiform layer using GABA. An integrin alpha-2 (human) that has had the signal peptide removed. UniProtKB:P17301, 30-1181. - PRO:DNx + PRO:DNx Reactome:R-HSA-57562 @@ -204771,21 +205213,21 @@ plexiform layer using GABA. PRO_0000016233 - PRO:DNx + PRO:DNx UniProtKB:P17301, 30-1181 - PRO:DNx + PRO:DNx hITGA2/SigPep- - PRO:DNx + PRO:DNx @@ -204821,7 +205263,7 @@ plexiform layer using GABA. An integrin alpha-4 (human) that has had the signal peptide removed. UniProtKB:P13612, 34-1032. - PRO:DNx + PRO:DNx Reactome:R-HSA-198007 @@ -204834,21 +205276,21 @@ plexiform layer using GABA. PRO_0000016244 - PRO:DNx + PRO:DNx UniProtKB:P13612, 34-1032 - PRO:DNx + PRO:DNx hITGA4/SigPep- - PRO:DNx + PRO:DNx @@ -204887,7 +205329,7 @@ plexiform layer using GABA. An integrin alpha-X (human) that has had the signal peptide removed. UniProtKB:P20702, 20-1163. - PRO:DNx + PRO:DNx Reactome:R-HSA-202764 @@ -204918,21 +205360,21 @@ plexiform layer using GABA. PRO_0000016294 - PRO:DNx + PRO:DNx UniProtKB:P20702, 20-1163 - PRO:DNx + PRO:DNx hITGAX/SigPep- - PRO:DNx + PRO:DNx @@ -204973,7 +205415,7 @@ plexiform layer using GABA. A vascular endothelial growth factor receptor 2 (human) that has had the signal peptide removed. UniProtKB:P35968, 20-1356. - PRO:DNx + PRO:DNx Reactome:R-HSA-195382 @@ -204986,21 +205428,21 @@ plexiform layer using GABA. PRO_0000016771 - PRO:DNx + PRO:DNx UniProtKB:P35968, 20-1356 - PRO:DNx + PRO:DNx hKDR/SigPep- - PRO:DNx + PRO:DNx @@ -205041,7 +205483,7 @@ plexiform layer using GABA. A mast/stem cell growth factor receptor Kit (human) that has had the signal peptide removed. UniProtKB:P10721, 26-976. - PRO:DNx + PRO:DNx Reactome:R-HSA-197662 @@ -205054,21 +205496,21 @@ plexiform layer using GABA. PRO_0000016754 - PRO:DNx + PRO:DNx UniProtKB:P10721, 26-976 - PRO:DNx + PRO:DNx hKIT/SigPep- - PRO:DNx + PRO:DNx @@ -205105,7 +205547,7 @@ plexiform layer using GABA. A neutrophil gelatinase-associated lipocalin (human) that has had the signal peptide removed. UniProtKB:P80188, 21-198. - PRO:DNx + PRO:DNx Reactome:R-HSA-5215934 @@ -205124,21 +205566,21 @@ plexiform layer using GABA. PRO_0000017933 - PRO:DNx + PRO:DNx UniProtKB:P80188, 21-198 - PRO:DNx + PRO:DNx hLCN2/SigPep- - PRO:DNx + PRO:DNx @@ -205179,7 +205621,7 @@ plexiform layer using GABA. A leukocyte immunoglobulin-like receptor subfamily A member 4 (human) that has had the signal peptide removed. UniProtKB:P59901, 24-499. - PRO:DNx + PRO:DNx Reactome:R-HSA-6786744 @@ -205192,21 +205634,21 @@ plexiform layer using GABA. PRO_0000014819 - PRO:DNx + PRO:DNx UniProtKB:P59901, 24-499 - PRO:DNx + PRO:DNx hLILRA4/SigPep- - PRO:DNx + PRO:DNx @@ -205245,7 +205687,7 @@ plexiform layer using GABA. A lactotransferrin (human) that has had the signal peptide removed. UniProtKB:P02788, 20-710. - PRO:DNx + PRO:DNx Reactome:R-HSA-1222567 Reactome:R-HSA-977171 @@ -205277,21 +205719,21 @@ plexiform layer using GABA. PRO_0000035732 - PRO:DNx + PRO:DNx UniProtKB:P02788, 20-710 - PRO:DNx + PRO:DNx hLTF/SigPep- - PRO:DNx + PRO:DNx @@ -205327,7 +205769,7 @@ plexiform layer using GABA. A lumican (human) that has had the signal peptide removed. UniProtKB:P51884, 19-338. - PRO:DNx + PRO:DNx Reactome:R-HSA-2466189 @@ -205340,21 +205782,21 @@ plexiform layer using GABA. PRO_0000032733 - PRO:DNx + PRO:DNx UniProtKB:P51884, 19-338 - PRO:DNx + PRO:DNx hLUM/SigPep- - PRO:DNx + PRO:DNx @@ -205395,7 +205837,7 @@ plexiform layer using GABA. A tyrosine-protein kinase Mer (human) that has had the signal peptide removed. UniProtKB:Q12866, 21-999. - PRO:DNx + PRO:DNx Reactome:R-HSA-197593 @@ -205408,21 +205850,21 @@ plexiform layer using GABA. PRO_0000024443 - PRO:DNx + PRO:DNx UniProtKB:Q12866, 21-999 - PRO:DNx + PRO:DNx hMERTK/SigPep- - PRO:DNx + PRO:DNx @@ -205465,7 +205907,7 @@ plexiform layer using GABA. A macrophage mannose receptor 1 (human) that has had the signal peptide removed. UniProtKB:P22897, 19-1456. - PRO:DNx + PRO:DNx Reactome:R-HSA-1216515 Reactome:R-HSA-1236785 Reactome:R-HSA-1236818 @@ -205492,21 +205934,21 @@ plexiform layer using GABA. PRO_0000017548 - PRO:DNx + PRO:DNx UniProtKB:P22897, 19-1456 - PRO:DNx + PRO:DNx hMRC1/SigPep- - PRO:DNx + PRO:DNx @@ -205542,7 +205984,7 @@ plexiform layer using GABA. A neural cell adhesion molecule 1 (human) that has had the signal peptide removed. UniProtKB:P13591, 20-858. - PRO:DNx + PRO:DNx Reactome:R-HSA-190987 @@ -205555,21 +205997,21 @@ plexiform layer using GABA. PRO_0000015009 - PRO:DNx + PRO:DNx UniProtKB:P13591, 20-858 - PRO:DNx + PRO:DNx hNCAM1/SigPep- - PRO:DNx + PRO:DNx @@ -205610,7 +206052,7 @@ plexiform layer using GABA. A natural cytotoxicity triggering receptor 1 (human) that has had the signal peptide removed. UniProtKB:O76036, 22-304. - PRO:DNx + PRO:DNx Reactome:R-HSA-197739 @@ -205623,21 +206065,21 @@ plexiform layer using GABA. PRO_0000015027 - PRO:DNx + PRO:DNx UniProtKB:O76036, 22-304 - PRO:DNx + PRO:DNx hNCR1/SigPep- - PRO:DNx + PRO:DNx @@ -205678,7 +206120,7 @@ plexiform layer using GABA. A natural cytotoxicity triggering receptor 2 (human) that has had the signal peptide removed. UniProtKB:O95944, 22-276. - PRO:DNx + PRO:DNx Reactome:R-HSA-197652 @@ -205691,21 +206133,21 @@ plexiform layer using GABA. PRO_0000015031 - PRO:DNx + PRO:DNx UniProtKB:O95944, 22-276 - PRO:DNx + PRO:DNx hNCR2/SigPep- - PRO:DNx + PRO:DNx @@ -205746,7 +206188,7 @@ plexiform layer using GABA. A programmed cell death protein 1 (human) that has had the signal peptide removed. UniProtKB:Q15116, 21-288. - PRO:DNx + PRO:DNx Reactome:R-HSA-197604 @@ -205759,21 +206201,21 @@ plexiform layer using GABA. PRO_0000014892 - PRO:DNx + PRO:DNx UniProtKB:Q15116, 21-288 - PRO:DNx + PRO:DNx hPDCD1/SigPep- - PRO:DNx + PRO:DNx @@ -205809,7 +206251,7 @@ plexiform layer using GABA. A platelet-derived growth factor receptor alpha (human) that has had the signal peptide removed. UniProtKB:P16234, 24-1089. - PRO:DNx + PRO:DNx Reactome:R-HSA-186794 @@ -205822,21 +206264,21 @@ plexiform layer using GABA. PRO_0000016760 - PRO:DNx + PRO:DNx UniProtKB:P16234, 24-1089 - PRO:DNx + PRO:DNx hPDGFRA/SigPep- - PRO:DNx + PRO:DNx @@ -205871,7 +206313,7 @@ plexiform layer using GABA. A urokinase plasminogen activator surface receptor (human) that has had the signal peptide removed. UniProtKB:Q03405, 23-335. - PRO:DNx + PRO:DNx Reactome:R-HSA-162866 @@ -205884,14 +206326,14 @@ plexiform layer using GABA. UniProtKB:Q03405, 23-335 - PRO:DNx + PRO:DNx hPLAUR/SigPep- - PRO:DNx + PRO:DNx @@ -205928,7 +206370,7 @@ plexiform layer using GABA. A receptor-type tyrosine-protein phosphatase C (human) that has had the signal peptide removed. UniProtKB:P08575, 24-1304. - PRO:DNx + PRO:DNx Reactome:R-HSA-197931 @@ -205947,21 +206389,21 @@ plexiform layer using GABA. PRO_0000025470 - PRO:DNx + PRO:DNx UniProtKB:P08575, 24-1304 - PRO:DNx + PRO:DNx hPTPRC/SigPep- - PRO:DNx + PRO:DNx @@ -206004,7 +206446,7 @@ plexiform layer using GABA. A syndecan-1 (human) that has had the signal peptide removed. UniProtKB:P18827, 23-310. - PRO:DNx + PRO:DNx Reactome:R-HSA-174758 Reactome:R-HSA-2054105 Reactome:R-HSA-2090025 @@ -206031,21 +206473,21 @@ plexiform layer using GABA. PRO_0000033499 - PRO:DNx + PRO:DNx UniProtKB:P18827, 23-310 - PRO:DNx + PRO:DNx hSDC1/SigPep- - PRO:DNx + PRO:DNx @@ -206081,7 +206523,7 @@ plexiform layer using GABA. A sialoadhesin (human) that has had the signal peptide removed. UniProtKB:Q9BZZ2, 20-1709. - PRO:DNx + PRO:DNx Reactome:R-HSA-197569 @@ -206094,21 +206536,21 @@ plexiform layer using GABA. PRO_0000014968 - PRO:DNx + PRO:DNx UniProtKB:Q9BZZ2, 20-1709 - PRO:DNx + PRO:DNx hSIGLEC1/SigPep- - PRO:DNx + PRO:DNx @@ -206152,7 +206594,7 @@ plexiform layer using GABA. A sialic acid-binding Ig-like lectin 5 (human) that has had the signal peptide removed. UniProtKB:O15389, 17-551. - PRO:DNx + PRO:DNx Reactome:R-HSA-197711 @@ -206183,21 +206625,21 @@ plexiform layer using GABA. PRO_0000014944 - PRO:DNx + PRO:DNx UniProtKB:O15389, 17-551 - PRO:DNx + PRO:DNx hSIGLEC5/SigPep- - PRO:DNx + PRO:DNx @@ -206235,7 +206677,7 @@ plexiform layer using GABA. A tyrosine-protein phosphatase non-receptor type substrate 1 (human) that has had the signal peptide removed. UniProtKB:P78324, 31-504. - PRO:DNx + PRO:DNx Reactome:R-HSA-3209922 @@ -206260,21 +206702,21 @@ plexiform layer using GABA. PRO_0000014941 - PRO:DNx + PRO:DNx UniProtKB:P78324, 31-504 - PRO:DNx + PRO:DNx hSIRPA/SigPep- - PRO:DNx + PRO:DNx @@ -206310,7 +206752,7 @@ plexiform layer using GABA. A leukosialin (human) that has had the signal peptide removed. UniProtKB:P16150, 20-400. - PRO:DNx + PRO:DNx Reactome:R-HSA-204438 @@ -206323,21 +206765,21 @@ plexiform layer using GABA. PRO_0000021588 - PRO:DNx + PRO:DNx UniProtKB:P16150, 20-400 - PRO:DNx + PRO:DNx hSPN/SigPep- - PRO:DNx + PRO:DNx @@ -206373,7 +206815,7 @@ plexiform layer using GABA. A thrombomodulin (human) that has had the signal peptide removed. UniProtKB:P07204, 19-575. - PRO:DNx + PRO:DNx Reactome:R-HSA-141030 @@ -206386,21 +206828,21 @@ plexiform layer using GABA. PRO_0000007771 - PRO:DNx + PRO:DNx UniProtKB:P07204, 19-575 - PRO:DNx + PRO:DNx hTHBD/SigPep- - PRO:DNx + PRO:DNx @@ -206441,7 +206883,7 @@ plexiform layer using GABA. A tumor necrosis factor receptor superfamily member 11A (human) that has had the signal peptide removed. UniProtKB:Q9Y6Q6, 30-616. - PRO:DNx + PRO:DNx Reactome:R-HSA-5668756 @@ -206454,21 +206896,21 @@ plexiform layer using GABA. PRO_0000034585 - PRO:DNx + PRO:DNx UniProtKB:Q9Y6Q6, 30-616 - PRO:DNx + PRO:DNx hTNFRSF11A/SigPep- - PRO:DNx + PRO:DNx @@ -206514,7 +206956,7 @@ plexiform layer using GABA. fam:ion_chan - PRO:DAN + PRO:DAN @@ -206552,13 +206994,13 @@ plexiform layer using GABA. An immunoglobulin complex whose components are encoded in the genome of human. - PRO:DAN + PRO:DAN hIg - PRO:DAN + PRO:DAN @@ -206614,7 +207056,7 @@ plexiform layer using GABA. hIgD - PRO:DAN + PRO:DAN @@ -206678,7 +207120,7 @@ plexiform layer using GABA. hIgD/circulating - PRO:DAN + PRO:DAN @@ -206706,7 +207148,7 @@ plexiform layer using GABA. IgH - PRO:DAN + PRO:DAN @@ -206734,7 +207176,7 @@ plexiform layer using GABA. IgL - PRO:DAN + PRO:DAN @@ -206755,13 +207197,13 @@ plexiform layer using GABA. An immunoglobulin light chain protein that is produced from the immunoglobulin kappa locus. - PRO:DAN + PRO:DAN IgKappa - PRO:DAN + PRO:DAN @@ -206782,13 +207224,13 @@ plexiform layer using GABA. An immunoglobulin light chain protein that is produced from the immunoglobulin lambda locus. - PRO:DAN + PRO:DAN IgLambda - PRO:DAN + PRO:DAN @@ -206818,13 +207260,13 @@ plexiform layer using GABA. An immunoglobulin light chain protein that is encoded in the genome of human. - PRO:DAN + PRO:DAN hIgL - PRO:DAN + PRO:DAN @@ -206857,13 +207299,13 @@ plexiform layer using GABA. An Ig kappa light chain protein that is encoded in the genome of human. - PRO:DAN + PRO:DAN hIgKappa - PRO:DAN + PRO:DAN @@ -206896,13 +207338,13 @@ plexiform layer using GABA. An Ig lambda light chain protein that is encoded in the genome of human. - PRO:DAN + PRO:DAN hIgLambda - PRO:DAN + PRO:DAN @@ -206926,32 +207368,32 @@ plexiform layer using GABA. An immunoglobulin heavy chain protein in which the constant region is encoded by the IgD gene segment. - PRO:DAN + PRO:DAN IgHD - PRO:DAN + PRO:DAN immunoglobulin D heavy chain - PRO:DAN + PRO:DAN immunoglobulin delta heavy chain - PRO:DAN + PRO:DAN immunoglobulin heavy chain delta - PRO:DAN + PRO:DAN @@ -206986,32 +207428,32 @@ plexiform layer using GABA. An IgD heavy chain protein that is encoded in the genome of human. - PRO:DAN + PRO:DAN hIgHD - PRO:DAN + PRO:DAN immunoglobulin D heavy chain (human) - PRO:DAN + PRO:DAN immunoglobulin delta heavy chain (human) - PRO:DAN + PRO:DAN immunoglobulin heavy chain delta (human) - PRO:DAN + PRO:DAN @@ -207034,13 +207476,13 @@ plexiform layer using GABA. A receptor-type tyrosine-protein phosphatase C that is a translation product of a transcript that minimally includes the region encoded by the variable exon 4(A). GOC:add PRO:ADD - PRO:DAN + PRO:DAN PTPRC/iso:CD45R - PRO:DNx + PRO:DNx @@ -207079,13 +207521,13 @@ plexiform layer using GABA. An MHC class II histocompatibility antigen alpha chain DRA that is encoded in the genome of mouse. - PRO:DAN + PRO:DAN mH2-Ea - PRO:DAN + PRO:DAN @@ -207106,13 +207548,13 @@ plexiform layer using GABA. A protein that is a translation product of the human HBA1, HBA2, HBB, HBD, HBE1, HBG1, HBG2, HBM, HBQ1, or HBZ genes, 1:1 orthologs thereof, or semi-orthologs thereof. - PRO:DAN + PRO:DAN fam:Hb - PRO:DAN + PRO:DAN @@ -207155,7 +207597,7 @@ plexiform layer using GABA. An endothelial transcription factor GATA-2 that is encoded in the genome of mouse. OMA:O09100 - PRO:DNx + PRO:DNx @@ -207167,7 +207609,7 @@ plexiform layer using GABA. mGATA2 - PRO:DNx + PRO:DNx @@ -207223,7 +207665,7 @@ plexiform layer using GABA. An ectonucleotide pyrophosphatase/phosphodiesterase family member 3 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:O14638 @@ -207260,7 +207702,7 @@ plexiform layer using GABA. hENPP3 - PRO:DNx + PRO:DNx @@ -207329,7 +207771,7 @@ plexiform layer using GABA. A homeobox protein Meis2 that is encoded in the genome of human. - PRO:DNx + PRO:DNx UniProtKB:O14770 @@ -207342,7 +207784,7 @@ plexiform layer using GABA. hMEIS2 - PRO:DNx + PRO:DNx @@ -207405,7 +207847,7 @@ plexiform layer using GABA. A sialic acid-binding Ig-like lectin 5 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:O15389 @@ -207436,7 +207878,7 @@ plexiform layer using GABA. hSIGLEC5 - PRO:DNx + PRO:DNx @@ -207516,7 +207958,7 @@ plexiform layer using GABA. A tumor necrosis factor receptor superfamily member 11A that is encoded in the genome of mouse. OMA:O35305 - PRO:DNx + PRO:DNx @@ -207534,7 +207976,7 @@ plexiform layer using GABA. mTNFRSF11A - PRO:DNx + PRO:DNx @@ -207607,7 +208049,7 @@ plexiform layer using GABA. A platelet glycoprotein Ib alpha chain that is encoded in the genome of mouse. OMA:O35930 - PRO:DNx + PRO:DNx @@ -207643,7 +208085,7 @@ plexiform layer using GABA. mGP1BA - PRO:DNx + PRO:DNx @@ -207696,7 +208138,7 @@ plexiform layer using GABA. A prominin-1 that is encoded in the genome of human. - PRO:CNA + PRO:CNA UniProtKB:O43490 @@ -207715,7 +208157,7 @@ plexiform layer using GABA. hPROM1 - PRO:DNx + PRO:DNx @@ -207790,7 +208232,7 @@ plexiform layer using GABA. A C-C chemokine receptor type 6 that is encoded in the genome of mouse. OMA:O54689 - PRO:DNx + PRO:DNx @@ -207826,7 +208268,7 @@ plexiform layer using GABA. mCCR6 - PRO:DNx + PRO:DNx @@ -207886,7 +208328,7 @@ plexiform layer using GABA. A killer cell lectin-like receptor subfamily D member 1 that is encoded in the genome of mouse. OMA:O54707 PANTHER:PTHR22800:SF15 - PRO:DNx + PRO:DNx @@ -207904,7 +208346,7 @@ plexiform layer using GABA. mKLRD1 - PRO:DNx + PRO:DNx @@ -207964,7 +208406,7 @@ plexiform layer using GABA. An eomesodermin that is encoded in the genome of mouse. OMA:O54839 - PRO:DNx + PRO:DNx @@ -207988,7 +208430,7 @@ plexiform layer using GABA. mEOMES - PRO:DNx + PRO:DNx @@ -208049,7 +208491,7 @@ plexiform layer using GABA. A prominin-1 that is encoded in the genome of mouse. OMA:O54990 - PRO:DNx + PRO:DNx @@ -208067,7 +208509,7 @@ plexiform layer using GABA. mPROM1 - PRO:DNx + PRO:DNx @@ -208143,7 +208585,7 @@ plexiform layer using GABA. A natural cytotoxicity triggering receptor 1 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:O76036 @@ -208174,7 +208616,7 @@ plexiform layer using GABA. hNCR1 - PRO:DNx + PRO:DNx @@ -208253,7 +208695,7 @@ plexiform layer using GABA. A gamma-synuclein that is encoded in the genome of human. - PRO:DNx + PRO:DNx UniProtKB:O76070 @@ -208272,7 +208714,7 @@ plexiform layer using GABA. hSNCG - PRO:DNx + PRO:DNx @@ -208350,7 +208792,7 @@ plexiform layer using GABA. A CD83 molecule that is encoded in the genome of mouse. OMA:O88324 PANTHER:PTHR15193:SF0 - PRO:DNx + PRO:DNx @@ -208362,7 +208804,7 @@ plexiform layer using GABA. mCD83 - PRO:DNx + PRO:DNx @@ -208417,7 +208859,7 @@ plexiform layer using GABA. A C-X-C chemokine receptor type 3 that is encoded in the genome of mouse. OMA:O88410 - PRO:DNx + PRO:DNx @@ -208453,7 +208895,7 @@ plexiform layer using GABA. mCXCR3 - PRO:DNx + PRO:DNx @@ -208511,13 +208953,13 @@ plexiform layer using GABA. A killer cell lectin-like receptor subfamily G member 1 that is encoded in the genome of mouse. OMA:O88713 - PRO:DNx + PRO:DNx mKLRG1 - PRO:DNx + PRO:DNx @@ -208591,7 +209033,7 @@ plexiform layer using GABA. A complement component C1q receptor that is encoded in the genome of mouse. OMA:O89103 - PRO:DNx + PRO:DNx @@ -208645,7 +209087,7 @@ plexiform layer using GABA. mCD93 - PRO:DNx + PRO:DNx @@ -208725,7 +209167,7 @@ plexiform layer using GABA. An eomesodermin that is encoded in the genome of human. - PRO:CNA + PRO:CNA UniProtKB:O95936 @@ -208750,7 +209192,7 @@ plexiform layer using GABA. hEOMES - PRO:DNx + PRO:DNx @@ -208812,7 +209254,7 @@ plexiform layer using GABA. A natural cytotoxicity triggering receptor 2 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:O95944 @@ -208843,7 +209285,7 @@ plexiform layer using GABA. hNCR2 - PRO:DNx + PRO:DNx @@ -208914,7 +209356,7 @@ plexiform layer using GABA. A proto-oncogene c-Fos that is encoded in the genome of human. - PRO:DNx + PRO:DNx UniProtKB:P01100 @@ -208939,7 +209381,7 @@ plexiform layer using GABA. hFOS - PRO:DNx + PRO:DNx @@ -208996,7 +209438,7 @@ plexiform layer using GABA. A proto-oncogene c-Fos that is encoded in the genome of mouse. OMA:P01101 - PRO:DNx + PRO:DNx @@ -209008,7 +209450,7 @@ plexiform layer using GABA. mFOS - PRO:DNx + PRO:DNx @@ -209058,27 +209500,27 @@ plexiform layer using GABA. A VIP peptides that is encoded in the genome of human. - PRO:DNx + PRO:DNx UniProtKB:P01282 hVIP - PRO:DNx + PRO:DNx vasoactive intestinal peptides (human) - PRO:DAN + PRO:DAN vasoactive intestinal polypeptides (human) - PRO:DAN + PRO:DAN @@ -209132,7 +209574,7 @@ plexiform layer using GABA. An interleukin-2 receptor subunit alpha that is encoded in the genome of human. - PRO:CNA + PRO:CNA UniProtKB:P01589 @@ -209181,7 +209623,7 @@ plexiform layer using GABA. hIL2RA - PRO:DNx + PRO:DNx @@ -209237,7 +209679,7 @@ plexiform layer using GABA. An interleukin-2 receptor subunit alpha that is encoded in the genome of mouse. OMA:P01590 - PRO:DNx + PRO:DNx @@ -209279,7 +209721,7 @@ plexiform layer using GABA. mIL2RA - PRO:DNx + PRO:DNx @@ -209335,7 +209777,7 @@ plexiform layer using GABA. A CD4 molecule that is encoded in the genome of human. - PRO:DNx + PRO:DNx UniProtKB:P01730 @@ -209348,7 +209790,7 @@ plexiform layer using GABA. hCD4 - PRO:DNx + PRO:DNx @@ -209401,7 +209843,7 @@ plexiform layer using GABA. A T-cell surface glycoprotein CD8 alpha chain that is encoded in the genome of mouse. OMA:P01731 - PRO:DNx + PRO:DNx @@ -209419,7 +209861,7 @@ plexiform layer using GABA. mCD8A - PRO:DNx + PRO:DNx @@ -209484,7 +209926,7 @@ plexiform layer using GABA. A T-cell surface glycoprotein CD8 alpha chain that is encoded in the genome of human. - PRO:CNA + PRO:CNA UniProtKB:P01732 @@ -209503,7 +209945,7 @@ plexiform layer using GABA. hCD8A - PRO:DNx + PRO:DNx @@ -209553,7 +209995,7 @@ plexiform layer using GABA. A T-cell surface glycoprotein CD8 alpha chain isoform 1 that is encoded in the genome of human. - PRO:DAN + PRO:DAN @@ -209571,7 +210013,7 @@ plexiform layer using GABA. hCD8A/iso:1 - PRO:DNx + PRO:DNx @@ -209616,7 +210058,7 @@ plexiform layer using GABA. A Thy-1 membrane glycoprotein that is encoded in the genome of mouse. OMA:P01831 - PRO:DNx + PRO:DNx @@ -209634,7 +210076,7 @@ plexiform layer using GABA. mTHY1 - PRO:DNx + PRO:DNx @@ -209693,7 +210135,7 @@ plexiform layer using GABA. An MHC class II histocompatibility antigen alpha chain DRA that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P01903 @@ -209712,7 +210154,7 @@ plexiform layer using GABA. hHLA-DRA - PRO:DNx + PRO:DNx @@ -209771,7 +210213,7 @@ plexiform layer using GABA. A hemoglobin subunit zeta that is encoded in the genome of human. - PRO:DNx + PRO:DNx UniProtKB:P02008 @@ -209784,7 +210226,7 @@ plexiform layer using GABA. hHBZ - PRO:DNx + PRO:DNx @@ -209854,7 +210296,7 @@ plexiform layer using GABA. A hemoglobin subunit beta-1 that is encoded in the genome of mouse. - PRO:DNx + PRO:DNx UniProtKB:P02088 @@ -209879,7 +210321,7 @@ plexiform layer using GABA. mHbb-b1 - PRO:DNx + PRO:DNx @@ -209928,7 +210370,7 @@ plexiform layer using GABA. A collagen alpha-1(I) chain that is encoded in the genome of human. - PRO:CNA + PRO:CNA UniProtKB:P02452 @@ -209941,7 +210383,7 @@ plexiform layer using GABA. hCOL1A1 - PRO:DNx + PRO:DNx @@ -209994,7 +210436,7 @@ plexiform layer using GABA. A glycophorin-A that is encoded in the genome of human. - PRO:CNA + PRO:CNA UniProtKB:P02724 @@ -210019,7 +210461,7 @@ plexiform layer using GABA. hGYPA - PRO:DNx + PRO:DNx @@ -210092,7 +210534,7 @@ plexiform layer using GABA. A transferrin receptor protein 1 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P02786 @@ -210171,7 +210613,7 @@ plexiform layer using GABA. hTFRC - PRO:DNx + PRO:DNx @@ -210224,7 +210666,7 @@ plexiform layer using GABA. A lactotransferrin that is encoded in the genome of human. - PRO:DNx + PRO:DNx UniProtKB:P02788 @@ -210237,7 +210679,7 @@ plexiform layer using GABA. hLTF - PRO:DNx + PRO:DNx @@ -210313,7 +210755,7 @@ plexiform layer using GABA. A glial fibrillary acidic protein that is encoded in the genome of mouse. OMA:P03995 - PRO:DNx + PRO:DNx @@ -210325,7 +210767,7 @@ plexiform layer using GABA. mGFAP - PRO:DNx + PRO:DNx @@ -210377,7 +210819,7 @@ plexiform layer using GABA. A DNA nucleotidylexotransferase that is encoded in the genome of human. - PRO:DNx + PRO:DNx UniProtKB:P04053 @@ -210390,7 +210832,7 @@ plexiform layer using GABA. hDNTT - PRO:DNx + PRO:DNx @@ -210460,7 +210902,7 @@ plexiform layer using GABA. A Thy-1 membrane glycoprotein that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P04216 @@ -210485,7 +210927,7 @@ plexiform layer using GABA. hTHY1 - PRO:DNx + PRO:DNx @@ -210539,7 +210981,7 @@ plexiform layer using GABA. An arginase-1 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P05089 @@ -210570,7 +211012,7 @@ plexiform layer using GABA. hARG1 - PRO:DNx + PRO:DNx @@ -210630,14 +211072,14 @@ plexiform layer using GABA. A myeloperoxidase that is encoded in the genome of human. - PRO:DNx + PRO:DNx UniProtKB:P05164 hMPO - PRO:DNx + PRO:DNx @@ -210691,7 +211133,7 @@ plexiform layer using GABA. A mast/stem cell growth factor receptor that is encoded in the genome of mouse. OMA:MOUSE17014 - PRO:DNx + PRO:DNx @@ -210709,7 +211151,7 @@ plexiform layer using GABA. mKIT - PRO:DNx + PRO:DNx @@ -210782,7 +211224,7 @@ plexiform layer using GABA. A lymphocyte antigen 6A-2/6E-1 that is encoded in the genome of mouse. - PRO:CNA + PRO:CNA UniProtKB:P05533 @@ -210819,7 +211261,7 @@ plexiform layer using GABA. mLy6a - PRO:DNx + PRO:DNx @@ -210880,7 +211322,7 @@ plexiform layer using GABA. An integrin alpha-M that is encoded in the genome of mouse. OMA:P05555 - PRO:DNx + PRO:DNx @@ -210916,7 +211358,7 @@ plexiform layer using GABA. mITGAM - PRO:DNx + PRO:DNx @@ -210969,7 +211411,7 @@ plexiform layer using GABA. A T-cell surface glycoprotein CD1a that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P06126 @@ -210988,7 +211430,7 @@ plexiform layer using GABA. hCD1A - PRO:DNx + PRO:DNx @@ -211050,14 +211492,14 @@ plexiform layer using GABA. A T-cell surface glycoprotein CD5 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P06127 hCD5 - PRO:DNx + PRO:DNx @@ -211118,14 +211560,14 @@ plexiform layer using GABA. A cholecystokinin that is encoded in the genome of human. - PRO:DNx + PRO:DNx UniProtKB:P06307 hCCK - PRO:DNx + PRO:DNx @@ -211177,7 +211619,7 @@ plexiform layer using GABA. A CD4 molecule that is encoded in the genome of mouse. OMA:P06332 - PRO:DNx + PRO:DNx @@ -211201,7 +211643,7 @@ plexiform layer using GABA. mCD4 - PRO:DNx + PRO:DNx @@ -211255,7 +211697,7 @@ plexiform layer using GABA. A hemoglobin subunit zeta that is encoded in the genome of mouse. OMA:P06467 - PRO:DNx + PRO:DNx @@ -211273,7 +211715,7 @@ plexiform layer using GABA. mHBZ - PRO:DNx + PRO:DNx @@ -211347,7 +211789,7 @@ plexiform layer using GABA. A CD2 molecule that is encoded in the genome of human. - PRO:CNA + PRO:CNA UniProtKB:P06729 @@ -211378,7 +211820,7 @@ plexiform layer using GABA. hCD2 - PRO:DNx + PRO:DNx @@ -211450,7 +211892,7 @@ plexiform layer using GABA. A low affinity immunoglobulin epsilon Fc receptor that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P06734 @@ -211487,7 +211929,7 @@ plexiform layer using GABA. hFCER2 - PRO:DNx + PRO:DNx @@ -211577,13 +212019,13 @@ plexiform layer using GABA. A myb proto-oncogene protein that is encoded in the genome of mouse. OMA:P06876 - PRO:DNx + PRO:DNx mMYB - PRO:DNx + PRO:DNx @@ -211641,7 +212083,7 @@ plexiform layer using GABA. A thrombomodulin that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P07204 @@ -211666,7 +212108,7 @@ plexiform layer using GABA. hTHBD - PRO:DNx + PRO:DNx @@ -211729,7 +212171,7 @@ plexiform layer using GABA. A macrophage colony-stimulating factor 1 receptor that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P07333 @@ -211766,7 +212208,7 @@ plexiform layer using GABA. hCSF1R - PRO:DNx + PRO:DNx @@ -211833,7 +212275,7 @@ plexiform layer using GABA. A platelet glycoprotein Ib alpha chain that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P07359 @@ -211876,7 +212318,7 @@ plexiform layer using GABA. hGP1BA - PRO:DNx + PRO:DNx @@ -211927,7 +212369,7 @@ plexiform layer using GABA. A CD3 epsilon that is encoded in the genome of human. - PRO:CNA + PRO:CNA UniProtKB:P07766 @@ -211946,7 +212388,7 @@ plexiform layer using GABA. hCD3E - PRO:DNx + PRO:DNx @@ -212003,7 +212445,7 @@ plexiform layer using GABA. A lactotransferrin that is encoded in the genome of mouse. OMA:P08071 - PRO:DNx + PRO:DNx @@ -212015,7 +212457,7 @@ plexiform layer using GABA. mLTF - PRO:DNx + PRO:DNx @@ -212072,7 +212514,7 @@ plexiform layer using GABA. A low affinity immunoglobulin gamma Fc region receptor II that is encoded in the genome of mouse. - PRO:CNA + PRO:CNA UniProtKB:P08101 @@ -212121,7 +212563,7 @@ plexiform layer using GABA. mFcgr2 - PRO:DNx + PRO:DNx @@ -212191,7 +212633,7 @@ plexiform layer using GABA. An early growth response protein 2 that is encoded in the genome of mouse. OMA:P08152 - PRO:DNx + PRO:DNx @@ -212215,7 +212657,7 @@ plexiform layer using GABA. mEGR2 - PRO:DNx + PRO:DNx @@ -212301,7 +212743,7 @@ plexiform layer using GABA. A neprilysin that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P08473 @@ -212350,7 +212792,7 @@ plexiform layer using GABA. hMME - PRO:DNx + PRO:DNx @@ -212427,7 +212869,7 @@ plexiform layer using GABA. A low affinity immunoglobulin gamma Fc region receptor III that is encoded in the genome of mouse. - PRO:CNA + PRO:CNA UniProtKB:P08508 @@ -212458,7 +212900,7 @@ plexiform layer using GABA. mFcgr3 - PRO:DNx + PRO:DNx @@ -212512,7 +212954,7 @@ plexiform layer using GABA. An integrin alpha-IIb that is encoded in the genome of human. - PRO:DNx + PRO:DNx UniProtKB:P08514 @@ -212537,7 +212979,7 @@ plexiform layer using GABA. hITGA2B - PRO:DNx + PRO:DNx @@ -212606,14 +213048,14 @@ plexiform layer using GABA. A CD14 molecule that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P08571 hCD14 - PRO:DNx + PRO:DNx @@ -212671,7 +213113,7 @@ plexiform layer using GABA. A receptor-type tyrosine-protein phosphatase C that is encoded in the genome of human. - PRO:CNA + PRO:CNA UniProtKB:P08575 @@ -212690,7 +213132,7 @@ plexiform layer using GABA. hPTPRC - PRO:DNx + PRO:DNx @@ -212744,13 +213186,13 @@ plexiform layer using GABA. A receptor-type tyrosine-protein phosphatase C isoform CD45RABC that is encoded in the genome of human. - PRO:DAN + PRO:DAN hPTPRC/iso:CD45RABC - PRO:DNx + PRO:DNx @@ -212787,7 +213229,7 @@ plexiform layer using GABA. A receptor-type tyrosine-protein phosphatase C isoform CD45RO that is encoded in the genome of human. GOC:add PRO:ADD - PRO:DAN + PRO:DAN @@ -212800,7 +213242,7 @@ plexiform layer using GABA. hPTPRC/iso:CD45RO - PRO:DNx + PRO:DNx @@ -212837,13 +213279,13 @@ plexiform layer using GABA. A receptor-type tyrosine-protein phosphatase C isoform CD45RA that is encoded in the genome of human. GOC:add PRO:ADD - PRO:DAN + PRO:DAN hPTPRC/iso:CD45RA - PRO:DNx + PRO:DNx @@ -212891,7 +213333,7 @@ plexiform layer using GABA. A CD2 molecule that is encoded in the genome of mouse. OMA:P08920 - PRO:DNx + PRO:DNx @@ -212927,7 +213369,7 @@ plexiform layer using GABA. mCD2 - PRO:DNx + PRO:DNx @@ -212984,7 +213426,7 @@ plexiform layer using GABA. A cholecystokinin that is encoded in the genome of mouse. OMA:P09240 - PRO:DNx + PRO:DNx @@ -212996,7 +213438,7 @@ plexiform layer using GABA. mCCK - PRO:DNx + PRO:DNx @@ -213053,7 +213495,7 @@ plexiform layer using GABA. A CD48 molecule that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P09326 @@ -213090,7 +213532,7 @@ plexiform layer using GABA. hCD48 - PRO:DNx + PRO:DNx @@ -213176,7 +213618,7 @@ plexiform layer using GABA. A galectin-1 that is encoded in the genome of human. - PRO:DNx + PRO:DNx UniProtKB:P09382 @@ -213237,7 +213679,7 @@ plexiform layer using GABA. hLGALS1 - PRO:DNx + PRO:DNx @@ -213307,7 +213749,7 @@ plexiform layer using GABA. A CD7 molecule that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P09564 @@ -213338,7 +213780,7 @@ plexiform layer using GABA. hCD7 - PRO:DNx + PRO:DNx @@ -213395,7 +213837,7 @@ plexiform layer using GABA. A macrophage colony-stimulating factor 1 receptor that is encoded in the genome of mouse. OMA:P09581 - PRO:DNx + PRO:DNx @@ -213431,7 +213873,7 @@ plexiform layer using GABA. mCSF1R - PRO:DNx + PRO:DNx @@ -213504,7 +213946,7 @@ plexiform layer using GABA. A cytotoxic T-lymphocyte protein 4 that is encoded in the genome of mouse. OMA:P09793 - PRO:DNx + PRO:DNx @@ -213528,7 +213970,7 @@ plexiform layer using GABA. mCTLA4 - PRO:DNx + PRO:DNx @@ -213589,7 +214031,7 @@ plexiform layer using GABA. A cadherin-1 that is encoded in the genome of mouse. OMA:P09803 - PRO:DNx + PRO:DNx @@ -213619,7 +214061,7 @@ plexiform layer using GABA. mCDH1 - PRO:DNx + PRO:DNx @@ -213679,7 +214121,7 @@ plexiform layer using GABA. A DNA nucleotidylexotransferase that is encoded in the genome of mouse. OMA:P09838 - PRO:DNx + PRO:DNx @@ -213691,7 +214133,7 @@ plexiform layer using GABA. mDNTT - PRO:DNx + PRO:DNx @@ -213766,7 +214208,7 @@ plexiform layer using GABA. A lymphocyte antigen 6C2 that is encoded in the genome of mouse. - PRO:CNA + PRO:CNA UniProtKB:P0CW03 @@ -213779,7 +214221,7 @@ plexiform layer using GABA. mLy6c2 - PRO:DNx + PRO:DNx @@ -213850,7 +214292,7 @@ plexiform layer using GABA. A granzyme B that is encoded in the genome of human. - PRO:CNA + PRO:CNA UniProtKB:P10144 @@ -213917,7 +214359,7 @@ plexiform layer using GABA. hGZMB - PRO:DNx + PRO:DNx @@ -214012,7 +214454,7 @@ plexiform layer using GABA. A non-secretory ribonuclease that is encoded in the genome of human. - PRO:DNx + PRO:DNx UniProtKB:P10153 @@ -214037,7 +214479,7 @@ plexiform layer using GABA. hRNASE2 - PRO:DNx + PRO:DNx @@ -214113,7 +214555,7 @@ plexiform layer using GABA. A myb proto-oncogene protein that is encoded in the genome of human. - PRO:DNx + PRO:DNx UniProtKB:P10242 @@ -214126,7 +214568,7 @@ plexiform layer using GABA. hMYB - PRO:DNx + PRO:DNx @@ -214189,7 +214631,7 @@ plexiform layer using GABA. A T-cell surface glycoprotein CD8 beta chain that is encoded in the genome of mouse. OMA:P10300 - PRO:DNx + PRO:DNx @@ -214219,7 +214661,7 @@ plexiform layer using GABA. mCD8B - PRO:DNx + PRO:DNx @@ -214304,7 +214746,7 @@ plexiform layer using GABA. A mast/stem cell growth factor receptor that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P10721 @@ -214323,7 +214765,7 @@ plexiform layer using GABA. hKIT - PRO:DNx + PRO:DNx @@ -214409,7 +214851,7 @@ plexiform layer using GABA. A T-cell-specific surface glycoprotein CD28 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P10747 @@ -214422,7 +214864,7 @@ plexiform layer using GABA. hCD28 - PRO:DNx + PRO:DNx @@ -214473,7 +214915,7 @@ plexiform layer using GABA. A CD14 molecule that is encoded in the genome of mouse. OMA:P10810 - PRO:WCB + PRO:WCB @@ -214485,7 +214927,7 @@ plexiform layer using GABA. mCD14 - PRO:DNx + PRO:DNx @@ -214544,7 +214986,7 @@ plexiform layer using GABA. A perforin-1 that is encoded in the genome of mouse. OMA:P10820 - PRO:DNx + PRO:DNx @@ -214568,7 +215010,7 @@ plexiform layer using GABA. mPRF1 - PRO:DNx + PRO:DNx @@ -214625,7 +215067,7 @@ plexiform layer using GABA. A T-cell surface glycoprotein CD8 beta chain that is encoded in the genome of human. - PRO:CNA + PRO:CNA UniProtKB:P10966 @@ -214638,7 +215080,7 @@ plexiform layer using GABA. hCD8B - PRO:DNx + PRO:DNx @@ -214688,7 +215130,7 @@ plexiform layer using GABA. A T-cell surface glycoprotein CD8 beta chain isoform 1 that is encoded in the genome of human. - PRO:DAN + PRO:DAN @@ -214706,7 +215148,7 @@ plexiform layer using GABA. hCD8B/iso:1 - PRO:DNx + PRO:DNx @@ -214750,7 +215192,7 @@ plexiform layer using GABA. A collagen alpha-1(I) chain that is encoded in the genome of mouse. OMA:P11087 - PRO:DNx + PRO:DNx @@ -214762,7 +215204,7 @@ plexiform layer using GABA. mCOL1A1 - PRO:DNx + PRO:DNx @@ -214824,7 +215266,7 @@ plexiform layer using GABA. An early growth response protein 2 that is encoded in the genome of human. - PRO:CNA + PRO:CNA UniProtKB:P11161 @@ -214861,7 +215303,7 @@ plexiform layer using GABA. hEGR2 - PRO:DNx + PRO:DNx @@ -214929,7 +215371,7 @@ plexiform layer using GABA. An integrin alpha-M that is encoded in the genome of human. - PRO:DNx + PRO:DNx UniProtKB:P11215 @@ -214954,7 +215396,7 @@ plexiform layer using GABA. hITGAM - PRO:DNx + PRO:DNx @@ -215030,7 +215472,7 @@ plexiform layer using GABA. A myeloperoxidase that is encoded in the genome of mouse. OMA:P11247 - PRO:DNx + PRO:DNx @@ -215042,7 +215484,7 @@ plexiform layer using GABA. mMPO - PRO:DNx + PRO:DNx @@ -215092,7 +215534,7 @@ plexiform layer using GABA. An antigen-presenting glycoprotein CD1d that is encoded in the genome of mouse. - PRO:WCB + PRO:WCB @@ -215104,7 +215546,7 @@ plexiform layer using GABA. mCD1D - PRO:DNx + PRO:DNx @@ -215167,7 +215609,7 @@ plexiform layer using GABA. A neutrophil gelatinase-associated lipocalin that is encoded in the genome of mouse. OMA:P11672 - PRO:DNx + PRO:DNx @@ -215203,7 +215645,7 @@ plexiform layer using GABA. mLCN2 - PRO:DNx + PRO:DNx @@ -215266,14 +215708,14 @@ plexiform layer using GABA. An eosinophil peroxidase that is encoded in the genome of human. - PRO:DNx + PRO:DNx UniProtKB:P11678 hEPX - PRO:DNx + PRO:DNx @@ -215347,7 +215789,7 @@ plexiform layer using GABA. A membrane-spanning 4-domains subfamily A member 1 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P11836 @@ -215366,7 +215808,7 @@ plexiform layer using GABA. hMS4A1 - PRO:DNx + PRO:DNx @@ -215439,7 +215881,7 @@ plexiform layer using GABA. An immunoglobulin iota chain that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P12018 @@ -215470,7 +215912,7 @@ plexiform layer using GABA. hVPREB1 - PRO:DNx + PRO:DNx @@ -215540,7 +215982,7 @@ plexiform layer using GABA. A high affinity immunoglobulin gamma Fc receptor I that is encoded in the genome of human. - PRO:CNA + PRO:CNA UniProtKB:P12314 @@ -215583,7 +216025,7 @@ plexiform layer using GABA. hFCGR1A - PRO:DNx + PRO:DNx @@ -215656,7 +216098,7 @@ plexiform layer using GABA. A high affinity immunoglobulin epsilon receptor subunit alpha that is encoded in the genome of human. - PRO:DNx + PRO:DNx UniProtKB:P12319 @@ -215681,7 +216123,7 @@ plexiform layer using GABA. hFCER1A - PRO:DNx + PRO:DNx @@ -215740,7 +216182,7 @@ plexiform layer using GABA. An eosinophil cationic protein that is encoded in the genome of human. - PRO:DNx + PRO:DNx UniProtKB:P12724 @@ -215753,7 +216195,7 @@ plexiform layer using GABA. hRNASE3 - PRO:DNx + PRO:DNx @@ -215828,7 +216270,7 @@ plexiform layer using GABA. A cadherin-1 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P12830 @@ -215859,7 +216301,7 @@ plexiform layer using GABA. hCDH1 - PRO:DNx + PRO:DNx @@ -215932,7 +216374,7 @@ plexiform layer using GABA. A T-cell surface glycoprotein CD5 that is encoded in the genome of mouse. OMA:P13379 - PRO:DNx + PRO:DNx @@ -215956,7 +216398,7 @@ plexiform layer using GABA. mCD5 - PRO:DNx + PRO:DNx @@ -216015,7 +216457,7 @@ plexiform layer using GABA. A neural cell adhesion molecule 1 that is encoded in the genome of human. - PRO:CNA + PRO:CNA UniProtKB:P13591 @@ -216040,7 +216482,7 @@ plexiform layer using GABA. hNCAM1 - PRO:DNx + PRO:DNx @@ -216100,7 +216542,7 @@ plexiform layer using GABA. A neural cell adhesion molecule 1 that is encoded in the genome of mouse. OMA:P13595 - PRO:DNx + PRO:DNx @@ -216124,7 +216566,7 @@ plexiform layer using GABA. mNCAM1 - PRO:DNx + PRO:DNx @@ -216183,7 +216625,7 @@ plexiform layer using GABA. An integrin alpha-4 that is encoded in the genome of human. - PRO:DNx + PRO:DNx UniProtKB:P13612 @@ -216202,7 +216644,7 @@ plexiform layer using GABA. hITGA4 - PRO:DNx + PRO:DNx @@ -216267,7 +216709,7 @@ plexiform layer using GABA. A tartrate-resistant acid phosphatase type 5 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P13686 @@ -216286,7 +216728,7 @@ plexiform layer using GABA. hACP5 - PRO:DNx + PRO:DNx @@ -216349,7 +216791,7 @@ plexiform layer using GABA. A bone marrow proteoglycan that is encoded in the genome of human. - PRO:DNx + PRO:DNx UniProtKB:P13727 @@ -216362,7 +216804,7 @@ plexiform layer using GABA. hPRG2 - PRO:DNx + PRO:DNx @@ -216416,13 +216858,13 @@ plexiform layer using GABA. A bone marrow proteoglycan isoform 1 that is encoded in the genome of human. - PRO:CNA + PRO:CNA hPRG2/iso:1 - PRO:DNx + PRO:DNx @@ -216465,7 +216907,7 @@ plexiform layer using GABA. A glial fibrillary acidic protein that is encoded in the genome of human. - PRO:DNx + PRO:DNx UniProtKB:P14136 @@ -216484,7 +216926,7 @@ plexiform layer using GABA. hGFAP - PRO:DNx + PRO:DNx @@ -216544,7 +216986,7 @@ plexiform layer using GABA. An L-selectin that is encoded in the genome of human. - PRO:JAN + PRO:JAN UniProtKB:P14151 @@ -216587,7 +217029,7 @@ plexiform layer using GABA. hSELL - PRO:DNx + PRO:DNx @@ -216677,7 +217119,7 @@ plexiform layer using GABA. A perforin-1 that is encoded in the genome of human. - PRO:CNA + PRO:CNA UniProtKB:P14222 @@ -216696,7 +217138,7 @@ plexiform layer using GABA. hPRF1 - PRO:DNx + PRO:DNx @@ -216765,7 +217207,7 @@ plexiform layer using GABA. An interleukin-1 receptor-like 1 that is encoded in the genome of mouse. OMA:P14719 - PRO:DNx + PRO:DNx @@ -216783,7 +217225,7 @@ plexiform layer using GABA. mIL1RL1 - PRO:DNx + PRO:DNx @@ -216873,7 +217315,7 @@ plexiform layer using GABA. An interleukin-2 receptor subunit beta that is encoded in the genome of human. - PRO:CNA + PRO:CNA UniProtKB:P14784 @@ -216910,7 +217352,7 @@ plexiform layer using GABA. hIL2RB - PRO:DNx + PRO:DNx @@ -216994,7 +217436,7 @@ plexiform layer using GABA. An aminopeptidase N that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P15144 @@ -217031,7 +217473,7 @@ plexiform layer using GABA. hANPEP - PRO:DNx + PRO:DNx @@ -217122,7 +217564,7 @@ plexiform layer using GABA. A thrombomodulin that is encoded in the genome of mouse. OMA:P15306 - PRO:DNx + PRO:DNx @@ -217146,7 +217588,7 @@ plexiform layer using GABA. mTHBD - PRO:DNx + PRO:DNx @@ -217208,7 +217650,7 @@ plexiform layer using GABA. A CD44 molecule that is encoded in the genome of mouse. OMA:P15379 - PRO:WCB + PRO:WCB @@ -217274,7 +217716,7 @@ plexiform layer using GABA. mCD44 - PRO:DNx + PRO:DNx @@ -217362,7 +217804,7 @@ plexiform layer using GABA. hCD19 - PRO:DNx + PRO:DNx @@ -217417,7 +217859,7 @@ plexiform layer using GABA. A leukosialin that is encoded in the genome of mouse. OMA:P15702 - PRO:DNx + PRO:DNx @@ -217453,7 +217895,7 @@ plexiform layer using GABA. mSPN - PRO:DNx + PRO:DNx @@ -217511,7 +217953,7 @@ plexiform layer using GABA. An antigen-presenting glycoprotein CD1d that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P15813 @@ -217530,7 +217972,7 @@ plexiform layer using GABA. hCD1D - PRO:DNx + PRO:DNx @@ -217590,7 +218032,7 @@ plexiform layer using GABA. An immunoglobulin lambda-like polypeptide 1 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P15814 @@ -217615,7 +218057,7 @@ plexiform layer using GABA. hIGLL1 - PRO:DNx + PRO:DNx @@ -217686,7 +218128,7 @@ plexiform layer using GABA. A V(D)J recombination-activating protein 1 that is encoded in the genome of human. - PRO:CNA + PRO:CNA UniProtKB:P15918 @@ -217711,7 +218153,7 @@ plexiform layer using GABA. hRAG1 - PRO:DNx + PRO:DNx @@ -217768,7 +218210,7 @@ plexiform layer using GABA. A V(D)J recombination-activating protein 1 that is encoded in the genome of mouse. OMA:P15919 - PRO:DNx + PRO:DNx @@ -217780,7 +218222,7 @@ plexiform layer using GABA. mRAG1 - PRO:DNx + PRO:DNx @@ -217835,7 +218277,7 @@ plexiform layer using GABA. An erythroid transcription factor that is encoded in the genome of human. - PRO:DNx + PRO:DNx UniProtKB:P15976 @@ -217872,7 +218314,7 @@ plexiform layer using GABA. hGATA1 - PRO:DNx + PRO:DNx @@ -217943,7 +218385,7 @@ plexiform layer using GABA. A galectin-1 that is encoded in the genome of mouse. OMA:P16045 - PRO:DNx + PRO:DNx @@ -217991,7 +218433,7 @@ plexiform layer using GABA. mLGALS1 - PRO:DNx + PRO:DNx @@ -218063,7 +218505,7 @@ plexiform layer using GABA. A CD44 molecule that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P16070 @@ -218118,7 +218560,7 @@ plexiform layer using GABA. hCD44 - PRO:DNx + PRO:DNx @@ -218230,7 +218672,7 @@ plexiform layer using GABA. A leukosialin that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P16150 @@ -218255,7 +218697,7 @@ plexiform layer using GABA. hSPN - PRO:DNx + PRO:DNx @@ -218335,7 +218777,7 @@ plexiform layer using GABA. An alpha-type platelet-derived growth factor receptor that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P16234 @@ -218390,7 +218832,7 @@ plexiform layer using GABA. hPDGFRA - PRO:DNx + PRO:DNx @@ -218471,7 +218913,7 @@ plexiform layer using GABA. An interleukin-2 receptor subunit beta that is encoded in the genome of mouse. OMA:P16297 - PRO:DNx + PRO:DNx @@ -218507,7 +218949,7 @@ plexiform layer using GABA. mIL2RB - PRO:DNx + PRO:DNx @@ -218567,7 +219009,7 @@ plexiform layer using GABA. A glutamyl aminopeptidase that is encoded in the genome of mouse. OMA:P16406 - PRO:DNx + PRO:DNx @@ -218603,7 +219045,7 @@ plexiform layer using GABA. mENPEP - PRO:DNx + PRO:DNx @@ -218654,7 +219096,7 @@ plexiform layer using GABA. A cytotoxic T-lymphocyte protein 4 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P16410 @@ -218673,7 +219115,7 @@ plexiform layer using GABA. hCTLA4 - PRO:DNx + PRO:DNx @@ -218741,7 +219183,7 @@ plexiform layer using GABA. A platelet glycoprotein 4 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P16671 @@ -218790,7 +219232,7 @@ plexiform layer using GABA. hCD36 - PRO:DNx + PRO:DNx @@ -218882,7 +219324,7 @@ plexiform layer using GABA. An interleukin-7 receptor subunit alpha that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P16871 @@ -218925,7 +219367,7 @@ plexiform layer using GABA. hIL7R - PRO:DNx + PRO:DNx @@ -218979,7 +219421,7 @@ plexiform layer using GABA. An interleukin-7 receptor subunit alpha that is encoded in the genome of mouse. OMA:P16872 - PRO:DNx + PRO:DNx @@ -219015,7 +219457,7 @@ plexiform layer using GABA. mIL7R - PRO:DNx + PRO:DNx @@ -219069,7 +219511,7 @@ plexiform layer using GABA. An integrin alpha-2 that is encoded in the genome of human. - PRO:CNA + PRO:CNA UniProtKB:P17301 @@ -219100,7 +219542,7 @@ plexiform layer using GABA. hITGA2 - PRO:DNx + PRO:DNx @@ -219166,7 +219608,7 @@ plexiform layer using GABA. A transcription factor PU.1 that is encoded in the genome of mouse. OMA:P17433 - PRO:DNx + PRO:DNx @@ -219184,7 +219626,7 @@ plexiform layer using GABA. mSPI1 - PRO:DNx + PRO:DNx @@ -219254,7 +219696,7 @@ plexiform layer using GABA. A T-cell acute lymphocytic leukemia protein 1 that is encoded in the genome of human. - PRO:DNx + PRO:DNx UniProtKB:P17542 @@ -219291,7 +219733,7 @@ plexiform layer using GABA. hTAL1 - PRO:DNx + PRO:DNx @@ -219367,7 +219809,7 @@ plexiform layer using GABA. An erythroid transcription factor that is encoded in the genome of mouse. OMA:P17679 - PRO:DNx + PRO:DNx @@ -219403,7 +219845,7 @@ plexiform layer using GABA. mGATA1 - PRO:DNx + PRO:DNx @@ -219460,7 +219902,7 @@ plexiform layer using GABA. An endoglin that is encoded in the genome of human. - PRO:CNA + PRO:CNA UniProtKB:P17813 @@ -219473,7 +219915,7 @@ plexiform layer using GABA. hENG - PRO:DNx + PRO:DNx @@ -219531,7 +219973,7 @@ plexiform layer using GABA. A complement receptor type 1 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P17927 @@ -219550,7 +219992,7 @@ plexiform layer using GABA. hCR1 - PRO:DNx + PRO:DNx @@ -219607,7 +220049,7 @@ plexiform layer using GABA. A transcription factor PU.1 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P17947 @@ -219626,7 +220068,7 @@ plexiform layer using GABA. hSPI1 - PRO:DNx + PRO:DNx @@ -219685,7 +220127,7 @@ plexiform layer using GABA. A CD48 molecule that is encoded in the genome of mouse. OMA:P18181 - PRO:DNx + PRO:DNx @@ -219733,7 +220175,7 @@ plexiform layer using GABA. mCD48 - PRO:DNx + PRO:DNx @@ -219813,7 +220255,7 @@ plexiform layer using GABA. An L-selectin that is encoded in the genome of mouse. OMA:P18337 - PRO:DNx + PRO:DNx @@ -219873,7 +220315,7 @@ plexiform layer using GABA. mSELL - PRO:DNx + PRO:DNx @@ -219945,7 +220387,7 @@ plexiform layer using GABA. A syndecan-1 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P18827 @@ -219964,7 +220406,7 @@ plexiform layer using GABA. hSDC1 - PRO:DNx + PRO:DNx @@ -220024,7 +220466,7 @@ plexiform layer using GABA. A syndecan-1 that is encoded in the genome of mouse. OMA:P18828 - PRO:DNx + PRO:DNx @@ -220042,7 +220484,7 @@ plexiform layer using GABA. mSDC1 - PRO:DNx + PRO:DNx @@ -220106,7 +220548,7 @@ plexiform layer using GABA. A complement receptor type 2 that is encoded in the genome of mouse. - PRO:WCB + PRO:WCB @@ -220124,7 +220566,7 @@ plexiform layer using GABA. mCR2 - PRO:DNx + PRO:DNx @@ -220180,7 +220622,7 @@ plexiform layer using GABA. A membrane-spanning 4-domains subfamily A member 1 that is encoded in the genome of mouse. OMA:P19437 - PRO:DNx + PRO:DNx @@ -220204,7 +220646,7 @@ plexiform layer using GABA. mMS4A1 - PRO:DNx + PRO:DNx @@ -220285,7 +220727,7 @@ plexiform layer using GABA. A complement receptor type 2 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P20023 @@ -220322,7 +220764,7 @@ plexiform layer using GABA. hCR2 - PRO:DNx + PRO:DNx @@ -220381,7 +220823,7 @@ plexiform layer using GABA. A CD33 molecule that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P20138 @@ -220394,7 +220836,7 @@ plexiform layer using GABA. hCD33 - PRO:DNx + PRO:DNx @@ -220467,7 +220909,7 @@ plexiform layer using GABA. A B-cell receptor CD22 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P20273 @@ -220492,7 +220934,7 @@ plexiform layer using GABA. hCD22 - PRO:DNx + PRO:DNx @@ -220559,14 +221001,14 @@ plexiform layer using GABA. A parvalbumin alpha that is encoded in the genome of human. - PRO:DNx + PRO:DNx UniProtKB:P20472 hPVALB - PRO:DNx + PRO:DNx @@ -220619,7 +221061,7 @@ plexiform layer using GABA. A high affinity immunoglobulin epsilon receptor subunit alpha that is encoded in the genome of mouse. OMA:P20489 - PRO:DNx + PRO:DNx @@ -220637,7 +221079,7 @@ plexiform layer using GABA. mFCER1A - PRO:DNx + PRO:DNx @@ -220703,7 +221145,7 @@ plexiform layer using GABA. A low affinity immunoglobulin epsilon Fc receptor that is encoded in the genome of mouse. OMA:P20693 - PRO:DNx + PRO:DNx @@ -220727,7 +221169,7 @@ plexiform layer using GABA. mFCER2 - PRO:DNx + PRO:DNx @@ -220799,7 +221241,7 @@ plexiform layer using GABA. hITGAX - PRO:DNx + PRO:DNx @@ -220872,7 +221314,7 @@ plexiform layer using GABA. A T-cell surface glycoprotein YE1/48 that is encoded in the genome of mouse. - PRO:DNx + PRO:DNx UniProtKB:P20937 @@ -220891,7 +221333,7 @@ plexiform layer using GABA. mKlra1 - PRO:DNx + PRO:DNx @@ -220974,7 +221416,7 @@ plexiform layer using GABA. An interleukin-5 receptor subunit alpha that is encoded in the genome of mouse. OMA:P21183 - PRO:DNx + PRO:DNx @@ -221010,7 +221452,7 @@ plexiform layer using GABA. mIL5RA - PRO:DNx + PRO:DNx @@ -221074,7 +221516,7 @@ plexiform layer using GABA. An fMet-Leu-Phe receptor that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P21462 @@ -221129,7 +221571,7 @@ plexiform layer using GABA. hFPR1 - PRO:DNx + PRO:DNx @@ -221181,7 +221623,7 @@ plexiform layer using GABA. A macrophage scavenger receptor types I and II that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P21757 @@ -221194,7 +221636,7 @@ plexiform layer using GABA. hMSR1 - PRO:DNx + PRO:DNx @@ -221264,7 +221706,7 @@ plexiform layer using GABA. A V(D)J recombination-activating protein 2 that is encoded in the genome of mouse. OMA:P21784 - PRO:DNx + PRO:DNx @@ -221276,7 +221718,7 @@ plexiform layer using GABA. mRAG2 - PRO:DNx + PRO:DNx @@ -221342,7 +221784,7 @@ plexiform layer using GABA. A CD9 molecule that is encoded in the genome of human. - PRO:DNx + PRO:DNx UniProtKB:P21926 @@ -221373,7 +221815,7 @@ plexiform layer using GABA. hCD9 - PRO:DNx + PRO:DNx @@ -221475,7 +221917,7 @@ plexiform layer using GABA. An alpha-(1,3)-fucosyltransferase 4 that is encoded in the genome of human. - PRO:CNA + PRO:CNA UniProtKB:P22083 @@ -221524,7 +221966,7 @@ plexiform layer using GABA. hFUT4 - PRO:DNx + PRO:DNx @@ -221591,7 +222033,7 @@ plexiform layer using GABA. A T-cell acute lymphocytic leukemia protein 1 that is encoded in the genome of mouse. OMA:P22091 - PRO:DNx + PRO:DNx @@ -221609,7 +222051,7 @@ plexiform layer using GABA. mTAL1 - PRO:DNx + PRO:DNx @@ -221674,7 +222116,7 @@ plexiform layer using GABA. A CD3 epsilon that is encoded in the genome of mouse. OMA:P22646 - PRO:DNx + PRO:DNx @@ -221692,7 +222134,7 @@ plexiform layer using GABA. mCD3E - PRO:DNx + PRO:DNx @@ -221750,7 +222192,7 @@ plexiform layer using GABA. A macrophage mannose receptor 1 that is encoded in the genome of human. - PRO:CNA + PRO:CNA UniProtKB:P22897 @@ -221787,7 +222229,7 @@ plexiform layer using GABA. hMRC1 - PRO:DNx + PRO:DNx @@ -221870,7 +222312,7 @@ plexiform layer using GABA. An endothelial transcription factor GATA-2 that is encoded in the genome of human. - PRO:DNx + PRO:DNx UniProtKB:P23769 @@ -221889,7 +222331,7 @@ plexiform layer using GABA. hGATA2 - PRO:DNx + PRO:DNx @@ -221939,7 +222381,7 @@ plexiform layer using GABA. A trans-acting T-cell-specific transcription factor GATA-3 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P23771 @@ -221958,7 +222400,7 @@ plexiform layer using GABA. hGATA3 - PRO:DNx + PRO:DNx @@ -222009,7 +222451,7 @@ plexiform layer using GABA. A trans-acting T-cell-specific transcription factor GATA-3 that is encoded in the genome of mouse. OMA:P23772 - PRO:DNx + PRO:DNx @@ -222021,7 +222463,7 @@ plexiform layer using GABA. mGATA3 - PRO:DNx + PRO:DNx @@ -222086,7 +222528,7 @@ plexiform layer using GABA. A signal transducer CD24 that is encoded in the genome of mouse. OMA:P24807 - PRO:WCB + PRO:WCB @@ -222128,7 +222570,7 @@ plexiform layer using GABA. mCD24 - PRO:DNx + PRO:DNx @@ -222208,7 +222650,7 @@ plexiform layer using GABA. A C-X-C chemokine receptor type 1 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P25024 @@ -222263,7 +222705,7 @@ plexiform layer using GABA. hCXCR1 - PRO:DNx + PRO:DNx @@ -222343,7 +222785,7 @@ plexiform layer using GABA. A C-X-C chemokine receptor type 2 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P25025 @@ -222404,7 +222846,7 @@ plexiform layer using GABA. hCXCR2 - PRO:DNx + PRO:DNx @@ -222467,14 +222909,14 @@ plexiform layer using GABA. A signal transducer CD24 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P25063 hCD24 - PRO:DNx + PRO:DNx @@ -222538,7 +222980,7 @@ plexiform layer using GABA. A CD19 molecule that is encoded in the genome of mouse. OMA:P25918 - PRO:DNx + PRO:DNx @@ -222556,7 +222998,7 @@ plexiform layer using GABA. mCD19 - PRO:DNx + PRO:DNx @@ -222605,7 +223047,7 @@ plexiform layer using GABA. An integrin beta-7 that is encoded in the genome of human. - PRO:DNx + PRO:DNx UniProtKB:P26010 @@ -222618,7 +223060,7 @@ plexiform layer using GABA. hITGB7 - PRO:DNx + PRO:DNx @@ -222669,7 +223111,7 @@ plexiform layer using GABA. An integrin beta-7 that is encoded in the genome of mouse. OMA:P26011 - PRO:DNx + PRO:DNx @@ -222687,7 +223129,7 @@ plexiform layer using GABA. mITGB7 - PRO:DNx + PRO:DNx @@ -222741,7 +223183,7 @@ plexiform layer using GABA. A high affinity immunoglobulin gamma Fc receptor I that is encoded in the genome of mouse. OMA:P26151 - PRO:DNx + PRO:DNx @@ -222771,7 +223213,7 @@ plexiform layer using GABA. mFCGR1A - PRO:DNx + PRO:DNx @@ -222834,7 +223276,7 @@ plexiform layer using GABA. An alpha-type platelet-derived growth factor receptor that is encoded in the genome of mouse. OMA:P26618 - PRO:DNx + PRO:DNx @@ -222876,7 +223318,7 @@ plexiform layer using GABA. mPDGFRA - PRO:DNx + PRO:DNx @@ -222936,7 +223378,7 @@ plexiform layer using GABA. An NKG2-A/NKG2-B type II integral membrane protein that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P26715 @@ -222973,7 +223415,7 @@ plexiform layer using GABA. hKLRC1 - PRO:DNx + PRO:DNx @@ -223033,7 +223475,7 @@ plexiform layer using GABA. A CD27 molecule that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P26842 @@ -223058,7 +223500,7 @@ plexiform layer using GABA. hCD27 - PRO:DNx + PRO:DNx @@ -223125,7 +223567,7 @@ plexiform layer using GABA. An interleukin-3 receptor class 2 alpha chain that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P26951 @@ -223162,7 +223604,7 @@ plexiform layer using GABA. hIL3RA - PRO:DNx + PRO:DNx @@ -223225,7 +223667,7 @@ plexiform layer using GABA. An interleukin-3 receptor class 2 alpha chain that is encoded in the genome of mouse. OMA:P26952 - PRO:DNx + PRO:DNx @@ -223267,7 +223709,7 @@ plexiform layer using GABA. mIL3RA - PRO:DNx + PRO:DNx @@ -223331,7 +223773,7 @@ plexiform layer using GABA. A tumor necrosis factor ligand superfamily member 5 that is encoded in the genome of mouse. OMA:P27548 - PRO:DNx + PRO:DNx @@ -223367,7 +223809,7 @@ plexiform layer using GABA. mCD40LG - PRO:DNx + PRO:DNx @@ -223446,7 +223888,7 @@ plexiform layer using GABA. A killer cell lectin-like receptor subfamily B member 1C that is encoded in the genome of mouse. - PRO:CNA + PRO:CNA UniProtKB:P27814 @@ -223501,7 +223943,7 @@ plexiform layer using GABA. mKlrb1c - PRO:DNx + PRO:DNx @@ -223569,7 +224011,7 @@ plexiform layer using GABA. hCD34 - PRO:DNx + PRO:DNx @@ -223626,7 +224068,7 @@ plexiform layer using GABA. An ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P28907 @@ -223681,7 +224123,7 @@ plexiform layer using GABA. hCD38 - PRO:DNx + PRO:DNx @@ -223732,7 +224174,7 @@ plexiform layer using GABA. A T-cell surface glycoprotein CD1c that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P29017 @@ -223745,7 +224187,7 @@ plexiform layer using GABA. hCD1C - PRO:DNx + PRO:DNx @@ -223808,7 +224250,7 @@ plexiform layer using GABA. A tumor necrosis factor ligand superfamily member 5 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P29965 @@ -223845,7 +224287,7 @@ plexiform layer using GABA. hCD40LG - PRO:DNx + PRO:DNx @@ -223926,7 +224368,7 @@ plexiform layer using GABA. A macrophage scavenger receptor types I and II that is encoded in the genome of mouse. OMA:P30204 - PRO:DNx + PRO:DNx @@ -223944,7 +224386,7 @@ plexiform layer using GABA. mMSR1 - PRO:DNx + PRO:DNx @@ -224013,7 +224455,7 @@ plexiform layer using GABA. A T-cell-specific surface glycoprotein CD28 that is encoded in the genome of mouse. OMA:P31041 - PRO:DNx + PRO:DNx @@ -224025,7 +224467,7 @@ plexiform layer using GABA. mCD28 - PRO:DNx + PRO:DNx @@ -224082,7 +224524,7 @@ plexiform layer using GABA. A low affinity immunoglobulin gamma Fc region receptor II-b that is encoded in the genome of human. - PRO:CNA + PRO:CNA UniProtKB:P31994 @@ -224125,7 +224567,7 @@ plexiform layer using GABA. hFCGR2B - PRO:DNx + PRO:DNx @@ -224196,7 +224638,7 @@ plexiform layer using GABA. A macrosialin that is encoded in the genome of mouse. OMA:P31996 - PRO:DNx + PRO:DNx @@ -224208,7 +224650,7 @@ plexiform layer using GABA. mCD68 - PRO:DNx + PRO:DNx @@ -224261,7 +224703,7 @@ plexiform layer using GABA. A carcinoembryonic antigen-related cell adhesion molecule 8 that is encoded in the genome of human. - PRO:CNA + PRO:CNA UniProtKB:P31997 @@ -224286,7 +224728,7 @@ plexiform layer using GABA. hCEACAM8 - PRO:DNx + PRO:DNx @@ -224361,7 +224803,7 @@ plexiform layer using GABA. A C-C chemokine receptor type 1 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P32246 @@ -224422,7 +224864,7 @@ plexiform layer using GABA. hCCR1 - PRO:DNx + PRO:DNx @@ -224510,7 +224952,7 @@ plexiform layer using GABA. A C-C chemokine receptor type 7 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P32248 @@ -224571,7 +225013,7 @@ plexiform layer using GABA. hCCR7 - PRO:DNx + PRO:DNx @@ -224650,7 +225092,7 @@ plexiform layer using GABA. A C-X-C chemokine receptor type 5 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P32302 @@ -224693,7 +225135,7 @@ plexiform layer using GABA. hCXCR5 - PRO:DNx + PRO:DNx @@ -224762,13 +225204,13 @@ plexiform layer using GABA. A VIP peptides that is encoded in the genome of mouse. OMA:P32648 - PRO:DNx + PRO:DNx mVIP - PRO:DNx + PRO:DNx @@ -224818,13 +225260,13 @@ plexiform layer using GABA. A parvalbumin alpha that is encoded in the genome of mouse. OMA:P32848 - PRO:DNx + PRO:DNx mPVALB - PRO:DNx + PRO:DNx @@ -224883,7 +225325,7 @@ plexiform layer using GABA. A cadherin-5 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P33151 @@ -224908,7 +225350,7 @@ plexiform layer using GABA. hCDH5 - PRO:DNx + PRO:DNx @@ -224969,7 +225411,7 @@ plexiform layer using GABA. A CD80 molecule that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P33681 @@ -225000,7 +225442,7 @@ plexiform layer using GABA. hCD80 - PRO:DNx + PRO:DNx @@ -225074,7 +225516,7 @@ plexiform layer using GABA. An fMet-Leu-Phe receptor that is encoded in the genome of mouse. OMA:P33766 - PRO:DNx + PRO:DNx @@ -225104,7 +225546,7 @@ plexiform layer using GABA. mFPR1 - PRO:DNx + PRO:DNx @@ -225153,7 +225595,7 @@ plexiform layer using GABA. A macrosialin that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P34810 @@ -225166,7 +225608,7 @@ plexiform layer using GABA. hCD68 - PRO:DNx + PRO:DNx @@ -225222,7 +225664,7 @@ plexiform layer using GABA. A B-cell receptor CD22 that is encoded in the genome of mouse. - PRO:WCB + PRO:WCB @@ -225252,7 +225694,7 @@ plexiform layer using GABA. mCD22 - PRO:DNx + PRO:DNx @@ -225335,7 +225777,7 @@ plexiform layer using GABA. A C-X-C chemokine receptor type 2 that is encoded in the genome of mouse. - PRO:WCB + PRO:WCB @@ -225377,7 +225819,7 @@ plexiform layer using GABA. mCXCR2 - PRO:DNx + PRO:DNx @@ -225450,7 +225892,7 @@ plexiform layer using GABA. A urokinase plasminogen activator surface receptor that is encoded in the genome of mouse. OMA:P35456 - PRO:DNx + PRO:DNx @@ -225468,7 +225910,7 @@ plexiform layer using GABA. mPLAUR - PRO:DNx + PRO:DNx @@ -225524,7 +225966,7 @@ plexiform layer using GABA. A lymphocyte antigen 6G that is encoded in the genome of mouse. - PRO:CNA + PRO:CNA UniProtKB:P35461 @@ -225543,7 +225985,7 @@ plexiform layer using GABA. mLy6g - PRO:DNx + PRO:DNx @@ -225600,7 +226042,7 @@ plexiform layer using GABA. A vascular endothelial growth factor receptor 2 that is encoded in the genome of mouse. OMA:P35918 - PRO:DNx + PRO:DNx @@ -225636,7 +226078,7 @@ plexiform layer using GABA. mKDR - PRO:DNx + PRO:DNx @@ -225713,7 +226155,7 @@ plexiform layer using GABA. A vascular endothelial growth factor receptor 2 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P35968 @@ -225744,7 +226186,7 @@ plexiform layer using GABA. hKDR - PRO:DNx + PRO:DNx @@ -225820,14 +226262,14 @@ plexiform layer using GABA. A neuronal acetylcholine receptor subunit alpha-7 that is encoded in the genome of human. - PRO:DNx + PRO:DNx UniProtKB:P36544 hCHRNA7 - PRO:DNx + PRO:DNx @@ -225893,7 +226335,7 @@ plexiform layer using GABA. A receptor-type tyrosine-protein kinase FLT3 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P36888 @@ -225942,7 +226384,7 @@ plexiform layer using GABA. hFLT3 - PRO:DNx + PRO:DNx @@ -226013,7 +226455,7 @@ plexiform layer using GABA. A CD69 molecule that is encoded in the genome of mouse. OMA:P37217 - PRO:DNx + PRO:DNx @@ -226025,7 +226467,7 @@ plexiform layer using GABA. mCD69 - PRO:DNx + PRO:DNx @@ -226077,7 +226519,7 @@ plexiform layer using GABA. An integrin alpha-E that is encoded in the genome of human. - PRO:CNA + PRO:CNA UniProtKB:P38570 @@ -226096,7 +226538,7 @@ plexiform layer using GABA. hITGAE - PRO:DNx + PRO:DNx @@ -226158,7 +226600,7 @@ plexiform layer using GABA. A CD9 molecule that is encoded in the genome of mouse. OMA:P40240 - PRO:DNx + PRO:DNx @@ -226170,7 +226612,7 @@ plexiform layer using GABA. mCD9 - PRO:DNx + PRO:DNx @@ -226229,7 +226671,7 @@ plexiform layer using GABA. A B-cell lymphoma 6 protein that is encoded in the genome of human. - PRO:CNA + PRO:CNA UniProtKB:P41182 @@ -226260,7 +226702,7 @@ plexiform layer using GABA. hBCL6 - PRO:DNx + PRO:DNx @@ -226356,13 +226798,13 @@ plexiform layer using GABA. A B-cell lymphoma 6 protein that is encoded in the genome of mouse. OMA:P41183 - PRO:DNx + PRO:DNx mBCL6 - PRO:DNx + PRO:DNx @@ -226423,7 +226865,7 @@ plexiform layer using GABA. A CD27 molecule that is encoded in the genome of mouse. OMA:P41272 - PRO:DNx + PRO:DNx @@ -226447,7 +226889,7 @@ plexiform layer using GABA. mCD27 - PRO:DNx + PRO:DNx @@ -226517,7 +226959,7 @@ plexiform layer using GABA. A C-C chemokine receptor type 2 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P41597 @@ -226560,7 +227002,7 @@ plexiform layer using GABA. hCCR2 - PRO:DNx + PRO:DNx @@ -226627,7 +227069,7 @@ plexiform layer using GABA. A CD86 molecule that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P42081 @@ -226664,7 +227106,7 @@ plexiform layer using GABA. hCD86 - PRO:DNx + PRO:DNx @@ -226724,7 +227166,7 @@ plexiform layer using GABA. A CD86 molecule that is encoded in the genome of mouse. OMA:P42082 - PRO:DNx + PRO:DNx @@ -226754,7 +227196,7 @@ plexiform layer using GABA. mCD86 - PRO:DNx + PRO:DNx @@ -226807,7 +227249,7 @@ plexiform layer using GABA. A cathepsin K that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P43235 @@ -226826,7 +227268,7 @@ plexiform layer using GABA. hCTSK - PRO:DNx + PRO:DNx @@ -226906,7 +227348,7 @@ plexiform layer using GABA. A C-C chemokine receptor type 7 that is encoded in the genome of mouse. OMA:P47774 - PRO:DNx + PRO:DNx @@ -226960,7 +227402,7 @@ plexiform layer using GABA. mCCR7 - PRO:DNx + PRO:DNx @@ -227040,7 +227482,7 @@ plexiform layer using GABA. A CX3C chemokine receptor 1 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P49238 @@ -227095,7 +227537,7 @@ plexiform layer using GABA. hCX3CR1 - PRO:DNx + PRO:DNx @@ -227160,7 +227602,7 @@ plexiform layer using GABA. An eosinophil peroxidase that is encoded in the genome of mouse. OMA:P49290 - PRO:DNx + PRO:DNx @@ -227172,7 +227614,7 @@ plexiform layer using GABA. mEPX - PRO:DNx + PRO:DNx @@ -227228,13 +227670,13 @@ plexiform layer using GABA. A neuronal acetylcholine receptor subunit alpha-7 that is encoded in the genome of mouse. - PRO:DAN + PRO:DAN mChrna7 - PRO:DNx + PRO:DNx @@ -227299,7 +227741,7 @@ plexiform layer using GABA. A C-X-C chemokine receptor type 3 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P49682 @@ -227348,7 +227790,7 @@ plexiform layer using GABA. hCXCR3 - PRO:DNx + PRO:DNx @@ -227412,7 +227854,7 @@ plexiform layer using GABA. A CCAAT/enhancer-binding protein alpha that is encoded in the genome of human. - PRO:DNx + PRO:DNx UniProtKB:P49715 @@ -227431,7 +227873,7 @@ plexiform layer using GABA. hCEBPA - PRO:DNx + PRO:DNx @@ -227488,7 +227930,7 @@ plexiform layer using GABA. A CD7 molecule that is encoded in the genome of mouse. OMA:P50283 - PRO:DNx + PRO:DNx @@ -227500,7 +227942,7 @@ plexiform layer using GABA. mCD7 - PRO:DNx + PRO:DNx @@ -227555,7 +227997,7 @@ plexiform layer using GABA. A LIM/homeobox protein Lhx3 that is encoded in the genome of mouse. OMA:P50481 - PRO:DNx + PRO:DNx @@ -227579,7 +228021,7 @@ plexiform layer using GABA. mLHX3 - PRO:DNx + PRO:DNx @@ -227657,7 +228099,7 @@ plexiform layer using GABA. A nuclear receptor ROR-gamma that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P51449 @@ -227676,7 +228118,7 @@ plexiform layer using GABA. hRORC - PRO:DNx + PRO:DNx @@ -227773,7 +228215,7 @@ plexiform layer using GABA. A nuclear receptor ROR-gamma that is encoded in the genome of mouse. OMA:P51450 - PRO:DNx + PRO:DNx @@ -227791,7 +228233,7 @@ plexiform layer using GABA. mRORC - PRO:DNx + PRO:DNx @@ -227878,13 +228320,13 @@ plexiform layer using GABA. A nuclear receptor ROR-gamma isoform 2 that is encoded in the genome of mouse. - PRO:CNA + PRO:CNA mRORC/iso:2 - PRO:DNx + PRO:DNx @@ -227941,7 +228383,7 @@ plexiform layer using GABA. A C-C chemokine receptor type 1 that is encoded in the genome of mouse. OMA:P51675 - PRO:DNx + PRO:DNx @@ -227989,7 +228431,7 @@ plexiform layer using GABA. mCCR1 - PRO:DNx + PRO:DNx @@ -228061,7 +228503,7 @@ plexiform layer using GABA. A C-C chemokine receptor type 3 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P51677 @@ -228122,7 +228564,7 @@ plexiform layer using GABA. hCCR3 - PRO:DNx + PRO:DNx @@ -228188,7 +228630,7 @@ plexiform layer using GABA. A C-C chemokine receptor type 3 that is encoded in the genome of mouse. OMA:P51678 - PRO:DNx + PRO:DNx @@ -228236,7 +228678,7 @@ plexiform layer using GABA. mCCR3 - PRO:DNx + PRO:DNx @@ -228312,7 +228754,7 @@ plexiform layer using GABA. A C-C chemokine receptor type 4 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P51679 @@ -228355,7 +228797,7 @@ plexiform layer using GABA. hCCR4 - PRO:DNx + PRO:DNx @@ -228417,7 +228859,7 @@ plexiform layer using GABA. A C-C chemokine receptor type 4 that is encoded in the genome of mouse. OMA:P51680 - PRO:DNx + PRO:DNx @@ -228453,7 +228895,7 @@ plexiform layer using GABA. mCCR4 - PRO:DNx + PRO:DNx @@ -228517,7 +228959,7 @@ plexiform layer using GABA. A C-C chemokine receptor type 5 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P51681 @@ -228566,7 +229008,7 @@ plexiform layer using GABA. hCCR5 - PRO:DNx + PRO:DNx @@ -228628,7 +229070,7 @@ plexiform layer using GABA. A C-C chemokine receptor type 5 that is encoded in the genome of mouse. OMA:P51682 - PRO:DNx + PRO:DNx @@ -228664,7 +229106,7 @@ plexiform layer using GABA. mCCR5 - PRO:DNx + PRO:DNx @@ -228728,7 +229170,7 @@ plexiform layer using GABA. A C-C chemokine receptor type 2 that is encoded in the genome of mouse. OMA:P51683 - PRO:DNx + PRO:DNx @@ -228776,7 +229218,7 @@ plexiform layer using GABA. mCCR2 - PRO:DNx + PRO:DNx @@ -228848,7 +229290,7 @@ plexiform layer using GABA. A C-C chemokine receptor type 6 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P51684 @@ -228927,7 +229369,7 @@ plexiform layer using GABA. hCCR6 - PRO:DNx + PRO:DNx @@ -229007,7 +229449,7 @@ plexiform layer using GABA. A lumican that is encoded in the genome of human. - PRO:DNx + PRO:DNx UniProtKB:P51884 @@ -229020,7 +229462,7 @@ plexiform layer using GABA. hLUM - PRO:DNx + PRO:DNx @@ -229093,7 +229535,7 @@ plexiform layer using GABA. A lumican that is encoded in the genome of mouse. OMA:P51885 - PRO:DNx + PRO:DNx @@ -229111,7 +229553,7 @@ plexiform layer using GABA. mLUM - PRO:DNx + PRO:DNx @@ -229176,7 +229618,7 @@ plexiform layer using GABA. A CCAAT/enhancer-binding protein alpha that is encoded in the genome of mouse. OMA:P53566 - PRO:DNx + PRO:DNx @@ -229188,7 +229630,7 @@ plexiform layer using GABA. mCEBPA - PRO:DNx + PRO:DNx @@ -229244,13 +229686,13 @@ plexiform layer using GABA. A cathepsin K that is encoded in the genome of mouse. OMA:P55097 - PRO:DNx + PRO:DNx mCTSK - PRO:DNx + PRO:DNx @@ -229302,7 +229744,7 @@ plexiform layer using GABA. A cadherin-5 that is encoded in the genome of mouse. OMA:P55284 - PRO:DNx + PRO:DNx @@ -229320,7 +229762,7 @@ plexiform layer using GABA. mCDH5 - PRO:DNx + PRO:DNx @@ -229376,7 +229818,7 @@ plexiform layer using GABA. A V(D)J recombination-activating protein 2 that is encoded in the genome of human. - PRO:CNA + PRO:CNA UniProtKB:P55895 @@ -229395,7 +229837,7 @@ plexiform layer using GABA. hRAG2 - PRO:DNx + PRO:DNx @@ -229454,7 +229896,7 @@ plexiform layer using GABA. An ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 that is encoded in the genome of mouse. OMA:P56528 - PRO:DNx + PRO:DNx @@ -229520,7 +229962,7 @@ plexiform layer using GABA. mCD38 - PRO:DNx + PRO:DNx @@ -229573,7 +230015,7 @@ plexiform layer using GABA. A leukocyte immunoglobulin-like receptor subfamily A member 4 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P59901 @@ -229598,7 +230040,7 @@ plexiform layer using GABA. hLILRA4 - PRO:DNx + PRO:DNx @@ -229661,13 +230103,13 @@ plexiform layer using GABA. A somatostatin that is encoded in the genome of mouse. OMA:P60041 - PRO:DNx + PRO:DNx mSST - PRO:DNx + PRO:DNx @@ -229739,7 +230181,7 @@ plexiform layer using GABA. A C-X-C chemokine receptor type 4 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P61073 @@ -229824,7 +230266,7 @@ plexiform layer using GABA. hCXCR4 - PRO:DNx + PRO:DNx @@ -229891,7 +230333,7 @@ plexiform layer using GABA. A somatostatin that is encoded in the genome of human. - PRO:DNx + PRO:DNx UniProtKB:P61278 @@ -229904,7 +230346,7 @@ plexiform layer using GABA. hSST - PRO:DNx + PRO:DNx @@ -229966,7 +230408,7 @@ plexiform layer using GABA. A C-X-C chemokine receptor type 4 that is encoded in the genome of mouse. OMA:P70658 - PRO:DNx + PRO:DNx @@ -230020,7 +230462,7 @@ plexiform layer using GABA. mCXCR4 - PRO:DNx + PRO:DNx @@ -230122,7 +230564,7 @@ plexiform layer using GABA. A tyrosine-protein phosphatase non-receptor type substrate 1 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:P78324 @@ -230189,7 +230631,7 @@ plexiform layer using GABA. hSIRPA - PRO:DNx + PRO:DNx @@ -230313,14 +230755,14 @@ plexiform layer using GABA. An iroquois-class homeodomain protein IRX-6 that is encoded in the genome of human. - PRO:DNx + PRO:DNx UniProtKB:P78412 hIRX6 - PRO:DNx + PRO:DNx @@ -230401,7 +230843,7 @@ plexiform layer using GABA. A neutrophil gelatinase-associated lipocalin that is encoded in the genome of human. - PRO:DNx + PRO:DNx UniProtKB:P80188 @@ -230420,7 +230862,7 @@ plexiform layer using GABA. hLCN2 - PRO:DNx + PRO:DNx @@ -230504,7 +230946,7 @@ plexiform layer using GABA. A homeobox protein Meis2 that is encoded in the genome of mouse. OMA:P97367 - PRO:DNx + PRO:DNx @@ -230516,7 +230958,7 @@ plexiform layer using GABA. mMEIS2 - PRO:DNx + PRO:DNx @@ -230589,7 +231031,7 @@ plexiform layer using GABA. An aminopeptidase N that is encoded in the genome of mouse. OMA:P97449 - PRO:DNx + PRO:DNx @@ -230625,7 +231067,7 @@ plexiform layer using GABA. mANPEP - PRO:DNx + PRO:DNx @@ -230721,7 +231163,7 @@ plexiform layer using GABA. A tyrosine-protein phosphatase non-receptor type substrate 1 that is encoded in the genome of mouse. - PRO:DAN + PRO:DAN @@ -230787,7 +231229,7 @@ plexiform layer using GABA. mSIRPA - PRO:DNx + PRO:DNx @@ -230886,7 +231328,7 @@ plexiform layer using GABA. A receptor-type tyrosine-protein kinase FLT3 that is encoded in the genome of mouse. OMA:Q00342 - PRO:DNx + PRO:DNx @@ -230928,7 +231370,7 @@ plexiform layer using GABA. mFLT3 - PRO:DNx + PRO:DNx @@ -231000,7 +231442,7 @@ plexiform layer using GABA. A CD80 molecule that is encoded in the genome of mouse. OMA:Q00609 - PRO:DNx + PRO:DNx @@ -231018,7 +231460,7 @@ plexiform layer using GABA. mCD80 - PRO:DNx + PRO:DNx @@ -231080,7 +231522,7 @@ plexiform layer using GABA. An integrin alpha-4 that is encoded in the genome of mouse. OMA:Q00651 - PRO:DNx + PRO:DNx @@ -231122,7 +231564,7 @@ plexiform layer using GABA. mITGA4 - PRO:DNx + PRO:DNx @@ -231177,7 +231619,7 @@ plexiform layer using GABA. A nuclear factor NF-kappa-B p100 subunit that is encoded in the genome of human. - PRO:DNx + PRO:DNx UniProtKB:Q00653 @@ -231202,7 +231644,7 @@ plexiform layer using GABA. hNFKB2 - PRO:DNx + PRO:DNx @@ -231277,7 +231719,7 @@ plexiform layer using GABA. A CD83 molecule that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:Q01151 @@ -231296,7 +231738,7 @@ plexiform layer using GABA. hCD83 - PRO:DNx + PRO:DNx @@ -231417,7 +231859,7 @@ plexiform layer using GABA. hRUNX1 - PRO:DNx + PRO:DNx @@ -231498,7 +231940,7 @@ plexiform layer using GABA. An interleukin-5 receptor subunit alpha that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:Q01344 @@ -231541,7 +231983,7 @@ plexiform layer using GABA. hIL5RA - PRO:DNx + PRO:DNx @@ -231600,14 +232042,14 @@ plexiform layer using GABA. An interleukin-1 receptor-like 1 that is encoded in the genome of human. - PRO:DNx + PRO:DNx UniProtKB:Q01638 hIL1RL1 - PRO:DNx + PRO:DNx @@ -231687,7 +232129,7 @@ plexiform layer using GABA. A programmed cell death protein 1 that is encoded in the genome of mouse. OMA:Q02242 - PRO:DNx + PRO:DNx @@ -231705,7 +232147,7 @@ plexiform layer using GABA. mPDCD1 - PRO:DNx + PRO:DNx @@ -231769,7 +232211,7 @@ plexiform layer using GABA. A paired box protein PAX-5 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:Q02548 @@ -231794,7 +232236,7 @@ plexiform layer using GABA. hPAX5 - PRO:DNx + PRO:DNx @@ -231846,7 +232288,7 @@ plexiform layer using GABA. A paired box protein PAX-5 that is encoded in the genome of mouse. OMA:Q02650 - PRO:DNx + PRO:DNx @@ -231864,7 +232306,7 @@ plexiform layer using GABA. mPAX5 - PRO:DNx + PRO:DNx @@ -231932,7 +232374,7 @@ plexiform layer using GABA. A runt-related transcription factor 1 that is encoded in the genome of mouse. OMA:Q03347 - PRO:DNx + PRO:DNx @@ -231980,7 +232422,7 @@ plexiform layer using GABA. mRUNX1 - PRO:DNx + PRO:DNx @@ -232066,7 +232508,7 @@ plexiform layer using GABA. A urokinase plasminogen activator surface receptor that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:Q03405 @@ -232085,7 +232527,7 @@ plexiform layer using GABA. hPLAUR - PRO:DNx + PRO:DNx @@ -232160,7 +232602,7 @@ plexiform layer using GABA. A C-X-C chemokine receptor type 5 that is encoded in the genome of mouse. OMA:Q04683 - PRO:DNx + PRO:DNx @@ -232190,7 +232632,7 @@ plexiform layer using GABA. mCXCR5 - PRO:DNx + PRO:DNx @@ -232259,7 +232701,7 @@ plexiform layer using GABA. A tartrate-resistant acid phosphatase type 5 that is encoded in the genome of mouse. OMA:Q05117 - PRO:DNx + PRO:DNx @@ -232277,7 +232719,7 @@ plexiform layer using GABA. mACP5 - PRO:DNx + PRO:DNx @@ -232357,7 +232799,7 @@ plexiform layer using GABA. A glutamyl aminopeptidase that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:Q07075 @@ -232400,7 +232842,7 @@ plexiform layer using GABA. hENPEP - PRO:DNx + PRO:DNx @@ -232458,7 +232900,7 @@ plexiform layer using GABA. A CD69 molecule that is encoded in the genome of human. - PRO:CNA + PRO:CNA UniProtKB:Q07108 @@ -232513,7 +232955,7 @@ plexiform layer using GABA. hCD69 - PRO:DNx + PRO:DNx @@ -232584,7 +233026,7 @@ plexiform layer using GABA. A natural killer cell receptor 2B4 that is encoded in the genome of mouse. OMA:Q07763 - PRO:DNx + PRO:DNx @@ -232620,7 +233062,7 @@ plexiform layer using GABA. mCD244 - PRO:DNx + PRO:DNx @@ -232702,7 +233144,7 @@ plexiform layer using GABA. A platelet glycoprotein 4 that is encoded in the genome of mouse. OMA:Q08857 - PRO:DNx + PRO:DNx @@ -232744,7 +233186,7 @@ plexiform layer using GABA. mCD36 - PRO:DNx + PRO:DNx @@ -232802,7 +233244,7 @@ plexiform layer using GABA. A bone marrow stromal antigen 2 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:Q10589 @@ -232827,7 +233269,7 @@ plexiform layer using GABA. hBST2 - PRO:DNx + PRO:DNx @@ -232888,7 +233330,7 @@ plexiform layer using GABA. An alpha-(1,3)-fucosyltransferase 4 that is encoded in the genome of mouse. OMA:Q11127 - PRO:DNx + PRO:DNx @@ -232924,7 +233366,7 @@ plexiform layer using GABA. mFUT4 - PRO:DNx + PRO:DNx @@ -232983,14 +233425,14 @@ plexiform layer using GABA. A tyrosine-protein kinase Mer that is encoded in the genome of human. - PRO:DNx + PRO:DNx UniProtKB:Q12866 hMERTK - PRO:DNx + PRO:DNx @@ -233065,7 +233507,7 @@ plexiform layer using GABA. A killer cell lectin-like receptor subfamily B member 1 that is encoded in the genome of human. - PRO:DAN + PRO:DAN @@ -233101,7 +233543,7 @@ plexiform layer using GABA. hKLRB1 - PRO:DNx + PRO:DNx @@ -233174,7 +233616,7 @@ plexiform layer using GABA. A killer cell lectin-like receptor subfamily D member 1 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:Q13241 @@ -233199,7 +233641,7 @@ plexiform layer using GABA. hKLRD1 - PRO:DNx + PRO:DNx @@ -233265,7 +233707,7 @@ plexiform layer using GABA. A SLAM family member 1 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:Q13291 @@ -233296,7 +233738,7 @@ plexiform layer using GABA. hSLAMF1 - PRO:DNx + PRO:DNx @@ -233358,7 +233800,7 @@ plexiform layer using GABA. A transmembrane emp24 domain-containing protein 1 that is encoded in the genome of human. - PRO:DNx + PRO:DNx UniProtKB:Q13445 @@ -233371,7 +233813,7 @@ plexiform layer using GABA. hTMED1 - PRO:DNx + PRO:DNx @@ -233465,7 +233907,7 @@ plexiform layer using GABA. A short transient receptor potential cation channel TRPC3 that is encoded in the genome of human. - PRO:CNA + PRO:CNA UniProtKB:Q13507 @@ -233490,7 +233932,7 @@ plexiform layer using GABA. hTRPC3 - PRO:DNx + PRO:DNx @@ -233569,7 +234011,7 @@ plexiform layer using GABA. An adhesion G protein-coupled receptor E1 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:Q14246 @@ -233588,7 +234030,7 @@ plexiform layer using GABA. hADGRE1 - PRO:DNx + PRO:DNx @@ -233654,7 +234096,7 @@ plexiform layer using GABA. A programmed cell death protein 1 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:Q15116 @@ -233673,7 +234115,7 @@ plexiform layer using GABA. hPDCD1 - PRO:DNx + PRO:DNx @@ -233736,7 +234178,7 @@ plexiform layer using GABA. A CCAAT/enhancer-binding protein epsilon that is encoded in the genome of human. - PRO:DNx + PRO:DNx UniProtKB:Q15744 @@ -233755,7 +234197,7 @@ plexiform layer using GABA. hCEBPE - PRO:DNx + PRO:DNx @@ -233808,7 +234250,7 @@ plexiform layer using GABA. A SLAM family member 5 that is encoded in the genome of mouse. OMA:Q18PI6 - PRO:DNx + PRO:DNx @@ -233826,7 +234268,7 @@ plexiform layer using GABA. mCD84 - PRO:DNx + PRO:DNx @@ -233890,7 +234332,7 @@ plexiform layer using GABA. A scavenger receptor cysteine-rich type 1 protein M130 that is encoded in the genome of mouse. OMA:Q2VLH6 - PRO:DNx + PRO:DNx @@ -233902,7 +234344,7 @@ plexiform layer using GABA. mCD163 - PRO:DNx + PRO:DNx @@ -233963,7 +234405,7 @@ plexiform layer using GABA. A transmembrane emp24 domain-containing protein 1 that is encoded in the genome of mouse. OMA:Q3V009 - PRO:DNx + PRO:DNx @@ -233975,7 +234417,7 @@ plexiform layer using GABA. mTMED1 - PRO:DNx + PRO:DNx @@ -234053,7 +234495,7 @@ plexiform layer using GABA. A cell surface glycoprotein CD200 receptor 3 that is encoded in the genome of mouse. - PRO:DNx + PRO:DNx UniProtKB:Q5UKY4 @@ -234084,7 +234526,7 @@ plexiform layer using GABA. mCd200r3 - PRO:DNx + PRO:DNx @@ -234144,7 +234586,7 @@ plexiform layer using GABA. A killer cell lectin-like receptor 4 that is encoded in the genome of mouse. - PRO:DNx + PRO:DNx UniProtKB:Q60651 @@ -234163,7 +234605,7 @@ plexiform layer using GABA. mKlra4 - PRO:DNx + PRO:DNx @@ -234235,7 +234677,7 @@ plexiform layer using GABA. An integrin alpha-E that is encoded in the genome of mouse. OMA:Q60677 - PRO:DNx + PRO:DNx @@ -234253,7 +234695,7 @@ plexiform layer using GABA. mITGAE - PRO:DNx + PRO:DNx @@ -234306,7 +234748,7 @@ plexiform layer using GABA. A killer cell lectin-like receptor 8 that is encoded in the genome of mouse. - PRO:DNx + PRO:DNx UniProtKB:Q60682 @@ -234325,7 +234767,7 @@ plexiform layer using GABA. mKlra8 - PRO:DNx + PRO:DNx @@ -234396,13 +234838,13 @@ plexiform layer using GABA. A macrophage receptor MARCO that is encoded in the genome of mouse. OMA:Q60754 - PRO:DNx + PRO:DNx mMARCO - PRO:DNx + PRO:DNx @@ -234460,7 +234902,7 @@ plexiform layer using GABA. A lymphocyte antigen 75 that is encoded in the genome of mouse. - PRO:DAN + PRO:DAN @@ -234484,7 +234926,7 @@ plexiform layer using GABA. mLY75 - PRO:DNx + PRO:DNx @@ -234543,13 +234985,13 @@ plexiform layer using GABA. A tyrosine-protein kinase Mer that is encoded in the genome of mouse. OMA:Q60805 - PRO:DNx + PRO:DNx mMERTK - PRO:DNx + PRO:DNx @@ -234619,7 +235061,7 @@ plexiform layer using GABA. An arginase-1 that is encoded in the genome of mouse. OMA:Q61176 - PRO:DNx + PRO:DNx @@ -234631,7 +235073,7 @@ plexiform layer using GABA. mARG1 - PRO:DNx + PRO:DNx @@ -234694,7 +235136,7 @@ plexiform layer using GABA. A neprilysin that is encoded in the genome of mouse. OMA:Q61391 - PRO:DNx + PRO:DNx @@ -234730,7 +235172,7 @@ plexiform layer using GABA. mMME - PRO:DNx + PRO:DNx @@ -234803,7 +235245,7 @@ plexiform layer using GABA. An adhesion G protein-coupled receptor E1 that is encoded in the genome of mouse. OMA:Q61549 - PRO:DNx + PRO:DNx @@ -234833,7 +235275,7 @@ plexiform layer using GABA. mADGRE1 - PRO:DNx + PRO:DNx @@ -234898,7 +235340,7 @@ plexiform layer using GABA. A macrophage mannose receptor 1 that is encoded in the genome of mouse. OMA:Q61830 - PRO:DNx + PRO:DNx @@ -234916,7 +235358,7 @@ plexiform layer using GABA. mMRC1 - PRO:DNx + PRO:DNx @@ -234968,7 +235410,7 @@ plexiform layer using GABA. A bone marrow proteoglycan that is encoded in the genome of mouse. OMA:Q61878 - PRO:DNx + PRO:DNx @@ -234980,7 +235422,7 @@ plexiform layer using GABA. mPRG2 - PRO:DNx + PRO:DNx @@ -235034,13 +235476,13 @@ plexiform layer using GABA. A bone marrow proteoglycan isoform 1 that is encoded in the genome of mouse. - PRO:CNA + PRO:CNA mPRG2/iso:1 - PRO:DNx + PRO:DNx @@ -235088,7 +235530,7 @@ plexiform layer using GABA. A sialoadhesin that is encoded in the genome of mouse. - PRO:WCB + PRO:WCB @@ -235106,7 +235548,7 @@ plexiform layer using GABA. mSIGLEC1 - PRO:DNx + PRO:DNx @@ -235192,7 +235634,7 @@ plexiform layer using GABA. A transferrin receptor protein 1 that is encoded in the genome of mouse. OMA:Q62351 - PRO:DNx + PRO:DNx @@ -235216,7 +235658,7 @@ plexiform layer using GABA. mTFRC - PRO:DNx + PRO:DNx @@ -235284,7 +235726,7 @@ plexiform layer using GABA. An integrin alpha-2 that is encoded in the genome of mouse. OMA:Q62469 - PRO:DNx + PRO:DNx @@ -235320,7 +235762,7 @@ plexiform layer using GABA. mITGA2 - PRO:DNx + PRO:DNx @@ -235378,7 +235820,7 @@ plexiform layer using GABA. An endoglin that is encoded in the genome of mouse. OMA:Q63961 - PRO:DNx + PRO:DNx @@ -235396,7 +235838,7 @@ plexiform layer using GABA. mENG - PRO:DNx + PRO:DNx @@ -235456,7 +235898,7 @@ plexiform layer using GABA. A CD33 molecule that is encoded in the genome of mouse. OMA:Q63994 - PRO:DNx + PRO:DNx @@ -235468,7 +235910,7 @@ plexiform layer using GABA. mCD33 - PRO:DNx + PRO:DNx @@ -235537,7 +235979,7 @@ plexiform layer using GABA. A CD34 molecule that is encoded in the genome of mouse. OMA:Q64314 - PRO:DNx + PRO:DNx @@ -235549,7 +235991,7 @@ plexiform layer using GABA. mCD34 - PRO:DNx + PRO:DNx @@ -235603,7 +236045,7 @@ plexiform layer using GABA. A killer cell lectin-like receptor 3 that is encoded in the genome of mouse. - PRO:DNx + PRO:DNx UniProtKB:Q64329 @@ -235634,7 +236076,7 @@ plexiform layer using GABA. mKlra3 - PRO:DNx + PRO:DNx @@ -235703,7 +236145,7 @@ plexiform layer using GABA. A lactosylceramide 4-alpha-galactosyltransferase that is encoded in the genome of mouse. OMA:Q67BJ4 - PRO:DNx + PRO:DNx @@ -235739,7 +236181,7 @@ plexiform layer using GABA. mA4GALT - PRO:DNx + PRO:DNx @@ -235753,7 +236195,7 @@ plexiform layer using GABA. alpha-1,4-N-acetylglucosaminyltransferase (mouse) - PRO:DNx + PRO:DNx UniProtKB:Q67BJ4 @@ -235800,7 +236242,7 @@ plexiform layer using GABA. An ectonucleotide pyrophosphatase/phosphodiesterase family member 3 that is encoded in the genome of mouse. OMA:Q6DYE8 - PRO:DNx + PRO:DNx @@ -235824,7 +236266,7 @@ plexiform layer using GABA. mENPP3 - PRO:DNx + PRO:DNx @@ -235891,7 +236333,7 @@ plexiform layer using GABA. A C-type lectin domain family 6 member A that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:Q6EIG7 @@ -235928,7 +236370,7 @@ plexiform layer using GABA. hCLEC6A - PRO:DNx + PRO:DNx @@ -235993,7 +236435,7 @@ plexiform layer using GABA. A CCAAT/enhancer-binding protein epsilon that is encoded in the genome of mouse. OMA:Q6PZD9 - PRO:DNx + PRO:DNx @@ -236005,7 +236447,7 @@ plexiform layer using GABA. mCEBPE - PRO:DNx + PRO:DNx @@ -236070,7 +236512,7 @@ plexiform layer using GABA. A C-type lectin domain family 7 member A that is encoded in the genome of mouse. OMA:Q6QLQ4 - PRO:DNx + PRO:DNx @@ -236112,7 +236554,7 @@ plexiform layer using GABA. mCLEC7A - PRO:DNx + PRO:DNx @@ -236183,14 +236625,14 @@ plexiform layer using GABA. A scavenger receptor cysteine-rich type 1 protein M130 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:Q86VB7 hCD163 - PRO:DNx + PRO:DNx @@ -236260,7 +236702,7 @@ plexiform layer using GABA. A natural cytotoxicity triggering receptor 1 that is encoded in the genome of mouse. - PRO:WCB + PRO:WCB @@ -236302,7 +236744,7 @@ plexiform layer using GABA. mNCR1 - PRO:DNx + PRO:DNx @@ -236373,7 +236815,7 @@ plexiform layer using GABA. A CD209 molecule-like protein B that is encoded in the genome of mouse. - PRO:DNx + PRO:DNx UniProtKB:Q8CJ91 @@ -236404,7 +236846,7 @@ plexiform layer using GABA. mCd209b - PRO:DNx + PRO:DNx @@ -236456,7 +236898,7 @@ plexiform layer using GABA. A bone marrow stromal antigen 2 that is encoded in the genome of mouse. OMA:Q8R2Q8 - PRO:DNx + PRO:DNx @@ -236480,7 +236922,7 @@ plexiform layer using GABA. mBST2 - PRO:DNx + PRO:DNx @@ -236532,7 +236974,7 @@ plexiform layer using GABA. A netrin-G1 that is encoded in the genome of mouse. OMA:Q8R4G0 - PRO:DNx + PRO:DNx @@ -236544,7 +236986,7 @@ plexiform layer using GABA. mNTNG1 - PRO:DNx + PRO:DNx @@ -236609,7 +237051,7 @@ plexiform layer using GABA. A neuropilin and tolloid-like protein 1 that is encoded in the genome of mouse. OMA:Q8R4I7 - PRO:DNx + PRO:DNx @@ -236621,7 +237063,7 @@ plexiform layer using GABA. mNETO1 - PRO:DNx + PRO:DNx @@ -236678,7 +237120,7 @@ plexiform layer using GABA. A neuropilin and tolloid-like protein 1 that is encoded in the genome of human. - PRO:DNx + PRO:DNx UniProtKB:Q8TDF5 @@ -236691,7 +237133,7 @@ plexiform layer using GABA. hNETO1 - PRO:DNx + PRO:DNx @@ -236750,7 +237192,7 @@ plexiform layer using GABA. A C-type lectin domain family 4 member K that is encoded in the genome of mouse. OMA:Q8VBX4 - PRO:DNx + PRO:DNx @@ -236768,7 +237210,7 @@ plexiform layer using GABA. mCD207 - PRO:DNx + PRO:DNx @@ -236838,7 +237280,7 @@ plexiform layer using GABA. A C-type lectin domain family 4 member C that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:Q8WTT0 @@ -236899,7 +237341,7 @@ plexiform layer using GABA. hCLEC4C - PRO:DNx + PRO:DNx @@ -236997,7 +237439,7 @@ plexiform layer using GABA. A killer cell lectin-like receptor subfamily G member 1 that is encoded in the genome of human. - PRO:DNx + PRO:DNx UniProtKB:Q96E93 @@ -237028,7 +237470,7 @@ plexiform layer using GABA. hKLRG1 - PRO:DNx + PRO:DNx @@ -237105,13 +237547,13 @@ plexiform layer using GABA. A forkhead box protein P3 that is encoded in the genome of mouse. OMA:Q99JB6 - PRO:DNx + PRO:DNx mFOXP3 - PRO:DNx + PRO:DNx @@ -237176,7 +237618,7 @@ plexiform layer using GABA. A C-type lectin domain family 7 member A that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:Q9BXN2 @@ -237225,7 +237667,7 @@ plexiform layer using GABA. hCLEC7A - PRO:DNx + PRO:DNx @@ -237305,7 +237747,7 @@ plexiform layer using GABA. A forkhead box protein P3 that is encoded in the genome of human. - PRO:CNA + PRO:CNA UniProtKB:Q9BZS1 @@ -237318,7 +237760,7 @@ plexiform layer using GABA. hFOXP3 - PRO:DNx + PRO:DNx @@ -237395,7 +237837,7 @@ plexiform layer using GABA. A natural killer cell receptor 2B4 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:Q9BZW8 @@ -237444,7 +237886,7 @@ plexiform layer using GABA. hCD244 - PRO:DNx + PRO:DNx @@ -237509,7 +237951,7 @@ plexiform layer using GABA. A sialoadhesin that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:Q9BZZ2 @@ -237522,7 +237964,7 @@ plexiform layer using GABA. hSIGLEC1 - PRO:DNx + PRO:DNx @@ -237595,7 +238037,7 @@ plexiform layer using GABA. A lysosome-associated membrane glycoprotein 5 that is encoded in the genome of mouse. OMA:Q9D387 - PRO:DNx + PRO:DNx @@ -237631,7 +238073,7 @@ plexiform layer using GABA. mLAMP5 - PRO:DNx + PRO:DNx @@ -237683,7 +238125,7 @@ plexiform layer using GABA. An iroquois-class homeodomain protein IRX-6 that is encoded in the genome of mouse. OMA:Q9ER75 - PRO:DNx + PRO:DNx @@ -237701,7 +238143,7 @@ plexiform layer using GABA. mIRX6 - PRO:DNx + PRO:DNx @@ -237767,7 +238209,7 @@ plexiform layer using GABA. An interleukin-17 receptor B that is encoded in the genome of mouse. OMA:Q9JIP3 - PRO:DNx + PRO:DNx @@ -237821,7 +238263,7 @@ plexiform layer using GABA. mIL17RB - PRO:DNx + PRO:DNx @@ -237889,7 +238331,7 @@ plexiform layer using GABA. A T-box transcription factor TBX21 that is encoded in the genome of mouse. OMA:Q9JKD8 - PRO:DNx + PRO:DNx @@ -237907,7 +238349,7 @@ plexiform layer using GABA. mTBX21 - PRO:DNx + PRO:DNx @@ -237983,7 +238425,7 @@ plexiform layer using GABA. A C-type lectin domain family 6 member A that is encoded in the genome of mouse. OMA:Q9JKF4 - PRO:DNx + PRO:DNx @@ -238013,7 +238455,7 @@ plexiform layer using GABA. mCLEC6A - PRO:DNx + PRO:DNx @@ -238071,7 +238513,7 @@ plexiform layer using GABA. A CD209 molecule that is encoded in the genome of human. Reactome:R-HSA-2079928 - UniProtKB:Q9NNX6 + UniProtKB:Q9NNX6 C-type lectin domain family 4 member L (human) DC-SIGN (human) DC-SIGN1 (human) @@ -238088,8 +238530,8 @@ plexiform layer using GABA. A CD209 molecule that is encoded in the genome of human. - PRO:WCB - UniProtKB:Q9NNX6 + PRO:WCB + UniProtKB:Q9NNX6 @@ -238101,45 +238543,45 @@ plexiform layer using GABA. C-type lectin domain family 4 member L (human) - UniProtKB:Q9NNX6 + UniProtKB:Q9NNX6 DC-SIGN (human) - UniProtKB:Q9NNX6 + UniProtKB:Q9NNX6 DC-SIGN1 (human) - UniProtKB:Q9NNX6 + UniProtKB:Q9NNX6 dendritic cell-specific ICAM-3-grabbing non-integrin 1 (human) - UniProtKB:Q9NNX6 + UniProtKB:Q9NNX6 hCD209 - PRO:DNx + PRO:DNx CD209 - UniProtKB:Q9NNX6 + UniProtKB:Q9NNX6 CLEC4L - UniProtKB:Q9NNX6 + UniProtKB:Q9NNX6 @@ -238190,7 +238632,7 @@ plexiform layer using GABA. A lactosylceramide 4-alpha-galactosyltransferase that is encoded in the genome of human. - PRO:DNx + PRO:DNx UniProtKB:Q9NPC4 @@ -238239,7 +238681,7 @@ plexiform layer using GABA. hA4GALT - PRO:DNx + PRO:DNx @@ -238316,7 +238758,7 @@ plexiform layer using GABA. A complement component C1q receptor that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:Q9NPY3 @@ -238359,7 +238801,7 @@ plexiform layer using GABA. hCD93 - PRO:DNx + PRO:DNx @@ -238439,7 +238881,7 @@ plexiform layer using GABA. An interleukin-17 receptor B that is encoded in the genome of human. - PRO:DNx + PRO:DNx UniProtKB:Q9NRM6 @@ -238488,7 +238930,7 @@ plexiform layer using GABA. hIL17RB - PRO:DNx + PRO:DNx @@ -238575,7 +239017,7 @@ plexiform layer using GABA. An integrin alpha-IIb that is encoded in the genome of mouse. OMA:Q9QUM0 - PRO:DNx + PRO:DNx @@ -238599,7 +239041,7 @@ plexiform layer using GABA. mITGA2B - PRO:DNx + PRO:DNx @@ -238657,7 +239099,7 @@ plexiform layer using GABA. A SLAM family member 1 that is encoded in the genome of mouse. OMA:Q9QUM4 - PRO:DNx + PRO:DNx @@ -238675,7 +239117,7 @@ plexiform layer using GABA. mSLAMF1 - PRO:DNx + PRO:DNx @@ -238735,7 +239177,7 @@ plexiform layer using GABA. An integrin alpha-X that is encoded in the genome of mouse. OMA:Q9QXH4 - PRO:DNx + PRO:DNx @@ -238765,7 +239207,7 @@ plexiform layer using GABA. mITGAX - PRO:DNx + PRO:DNx @@ -238822,7 +239264,7 @@ plexiform layer using GABA. A short transient receptor potential cation channel TRPC3 that is encoded in the genome of mouse. OMA:Q9QZC1 - PRO:DNx + PRO:DNx @@ -238846,7 +239288,7 @@ plexiform layer using GABA. mTRPC3 - PRO:DNx + PRO:DNx @@ -238928,7 +239370,7 @@ plexiform layer using GABA. A LIM/homeobox protein Lhx3 that is encoded in the genome of human. - PRO:DNx + PRO:DNx UniProtKB:Q9UBR4 @@ -238947,7 +239389,7 @@ plexiform layer using GABA. hLHX3 - PRO:DNx + PRO:DNx @@ -238998,14 +239440,14 @@ plexiform layer using GABA. A macrophage receptor MARCO that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:Q9UEW3 hMARCO - PRO:DNx + PRO:DNx @@ -239077,7 +239519,7 @@ plexiform layer using GABA. A SLAM family member 5 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:Q9UIB8 @@ -239096,7 +239538,7 @@ plexiform layer using GABA. hCD84 - PRO:DNx + PRO:DNx @@ -239168,7 +239610,7 @@ plexiform layer using GABA. A C-type lectin domain family 4 member K that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:Q9UJ71 @@ -239193,7 +239635,7 @@ plexiform layer using GABA. hCD207 - PRO:DNx + PRO:DNx @@ -239260,7 +239702,7 @@ plexiform layer using GABA. A lysosome-associated membrane glycoprotein 5 that is encoded in the genome of human. - PRO:DNx + PRO:DNx UniProtKB:Q9UJQ1 @@ -239291,7 +239733,7 @@ plexiform layer using GABA. hLAMP5 - PRO:DNx + PRO:DNx @@ -239357,7 +239799,7 @@ plexiform layer using GABA. A T-box transcription factor TBX21 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:Q9UL17 @@ -239376,7 +239818,7 @@ plexiform layer using GABA. hTBX21 - PRO:DNx + PRO:DNx @@ -239447,7 +239889,7 @@ plexiform layer using GABA. A nuclear factor NF-kappa-B p100 subunit that is encoded in the genome of mouse. OMA:Q9WTK5 - PRO:DNx + PRO:DNx @@ -239459,7 +239901,7 @@ plexiform layer using GABA. mNFKB2 - PRO:DNx + PRO:DNx @@ -239521,7 +239963,7 @@ plexiform layer using GABA. An inducible T-cell costimulator that is encoded in the genome of mouse. OMA:Q9WVS0 - PRO:DNx + PRO:DNx @@ -239557,7 +239999,7 @@ plexiform layer using GABA. mICOS - PRO:DNx + PRO:DNx @@ -239606,7 +240048,7 @@ plexiform layer using GABA. A netrin-G1 that is encoded in the genome of human. - UniProtKB:Q9Y2I2 + UniProtKB:Q9Y2I2 hNTNG1 laminet-1 (human) protein @@ -239622,48 +240064,48 @@ plexiform layer using GABA. A netrin-G1 that is encoded in the genome of human. - PRO:DNx - UniProtKB:Q9Y2I2 + PRO:DNx + UniProtKB:Q9Y2I2 hNTNG1 - PRO:DNx + PRO:DNx laminet-1 (human) - UniProtKB:Q9Y2I2 + UniProtKB:Q9Y2I2 KIAA0976 - UniProtKB:Q9Y2I2 + UniProtKB:Q9Y2I2 LMNT1 - UniProtKB:Q9Y2I2 + UniProtKB:Q9Y2I2 NTNG1 - UniProtKB:Q9Y2I2 + UniProtKB:Q9Y2I2 UNQ571/PRO1133 - UniProtKB:Q9Y2I2 + UniProtKB:Q9Y2I2 @@ -239712,7 +240154,7 @@ plexiform layer using GABA. A prostaglandin D2 receptor DP2 that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:Q9Y5Y4 @@ -239743,7 +240185,7 @@ plexiform layer using GABA. hPTGDR2 - PRO:DNx + PRO:DNx @@ -239817,7 +240259,7 @@ plexiform layer using GABA. A tumor necrosis factor receptor superfamily member 11A that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:Q9Y6Q6 @@ -239836,7 +240278,7 @@ plexiform layer using GABA. hTNFRSF11A - PRO:DNx + PRO:DNx @@ -239906,7 +240348,7 @@ plexiform layer using GABA. An inducible T-cell costimulator that is encoded in the genome of human. - PRO:WCB + PRO:WCB UniProtKB:Q9Y6W8 @@ -239925,7 +240367,7 @@ plexiform layer using GABA. hICOS - PRO:DNx + PRO:DNx @@ -239984,7 +240426,7 @@ plexiform layer using GABA. A CX3C chemokine receptor 1 that is encoded in the genome of mouse. OMA:Q9Z0D9 - PRO:DNx + PRO:DNx @@ -240008,7 +240450,7 @@ plexiform layer using GABA. mCX3CR1 - PRO:DNx + PRO:DNx @@ -240059,13 +240501,13 @@ plexiform layer using GABA. A gamma-synuclein that is encoded in the genome of mouse. OMA:Q9Z0F7 - PRO:DNx + PRO:DNx mSNCG - PRO:DNx + PRO:DNx @@ -240132,7 +240574,7 @@ plexiform layer using GABA. A prostaglandin D2 receptor DP2 that is encoded in the genome of mouse. OMA:Q9Z2J6 - PRO:DNx + PRO:DNx @@ -240156,7 +240598,7 @@ plexiform layer using GABA. mPTGDR2 - PRO:DNx + PRO:DNx @@ -241033,7 +241475,7 @@ plexiform layer using GABA. Hp BIRNLEX:1353 - NIFSTD:NeuroNames_abbrevSource + NIFSTD:NeuroNames_abbrevSource @@ -241970,7 +242412,7 @@ plexiform layer using GABA. A light sensing organ composed of ommatidia - FB:gg + FB:gg @@ -242239,19 +242681,19 @@ plexiform layer using GABA. organ of sense organ system - OBOL:accepted + OBOL:accepted organ of sensory organ system - OBOL:accepted + OBOL:accepted organ of sensory system - OBOL:accepted + OBOL:accepted @@ -242269,7 +242711,7 @@ plexiform layer using GABA. sensory system organ - OBOL:accepted + OBOL:accepted @@ -245615,7 +246057,7 @@ plexiform layer using GABA. Wolffian body BTO:0001542 - GOC:yaf + GOC:yaf MESH:A16.254.500 @@ -245761,7 +246203,7 @@ plexiform layer using GABA. - ISBN:9780878932504 + ISBN:9780878932504 @@ -245981,7 +246423,7 @@ plexiform layer using GABA. - ISBN:9780878932504 + ISBN:9780878932504 @@ -246569,7 +247011,7 @@ plexiform layer using GABA. bilaminary germ disc - ISBN:9780878932504 + ISBN:9780878932504 @@ -248358,7 +248800,7 @@ plexiform layer using GABA. - Wikipathways:WP2062 + Wikipathways:WP2062 @@ -249459,7 +249901,7 @@ plexiform layer using GABA. - FMA-abduced + FMA-abduced @@ -252346,7 +252788,7 @@ plexiform layer using GABA. - BTO + BTO @@ -253658,7 +254100,7 @@ plexiform layer using GABA. muscle organ of tongue - OBOL:accepted + OBOL:accepted @@ -254889,7 +255331,7 @@ plexiform layer using GABA. - BTO + BTO @@ -257965,7 +258407,7 @@ plexiform layer using GABA. Epithelium which consists of more than one layer of epithelial cells that may or may not be in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, ciliated stratified columnar epithelium.[FMA] - FMA:FMA + FMA:FMA @@ -259499,7 +259941,7 @@ plexiform layer using GABA. Cranial nerve fiber tract which is comprised of retinal ganglion cell axons running posterior medially towards the optic chiasm, at which some of the axons cross the midline and after which the structure is termed the optic tract. Transmits visual information from the retina to the brain[ZFA]. - ISBN:0471209627 + ISBN:0471209627 ISBN:0471888893 @@ -259541,7 +259983,7 @@ plexiform layer using GABA. 2n BIRNLEX:1640 - NIFSTD:NeuroNames_abbrevSource + NIFSTD:NeuroNames_abbrevSource @@ -260551,7 +260993,7 @@ plexiform layer using GABA. - GO + GO ISBN:0471888893 @@ -261975,7 +262417,7 @@ plexiform layer using GABA. Paired endochondral long bone that extends between the pectoral girdle and the skeletal parts of the forelimb. [PHENOSCAPE:mah] AAO:0000679 - PHENOSCAPE:mah + PHENOSCAPE:mah @@ -262013,21 +262455,21 @@ plexiform layer using GABA. mesomere 1 of pectoral appendage - ISBN:0226313409 + ISBN:0226313409 proximal metapterygial mesomere of pectoral appendage - ISBN:0226313409 + ISBN:0226313409 proximal metapterygial mesomere of pectoral fin - ISBN:0226313409 + ISBN:0226313409 @@ -262309,7 +262751,7 @@ plexiform layer using GABA. The major preaxial endochondral bone in the posterior zeugopod[Phenoscape]. - PHENOSCAPE:mah + PHENOSCAPE:mah @@ -262443,7 +262885,7 @@ plexiform layer using GABA. 2012-08-14 VSAO:0000186 VSAO - VSAO:NI + VSAO:NI @@ -262480,7 +262922,7 @@ plexiform layer using GABA. mesomere 1 of pevlic appendage - ISBN:0226313409 + ISBN:0226313409 @@ -262508,14 +262950,14 @@ plexiform layer using GABA. proximal metapterygial mesomere of pelvic appendage - ISBN:0226313409 + ISBN:0226313409 proximal metapterygial mesomere of pelvic fin - ISBN:0226313409 + ISBN:0226313409 @@ -265936,7 +266378,7 @@ plexiform layer using GABA. - FBbt + FBbt @@ -268706,7 +269148,7 @@ plexiform layer using GABA. 2012-06-20 AAO:0000739 AAO - AAO:Pugener_2002 + AAO:Pugener_2002 @@ -271797,7 +272239,7 @@ plexiform layer using GABA. A major subdivision of an organism that is the entire part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane. In vertebrares this includes the vertebral column.. BSPO:0000063 - UBERONREF:0000006 + UBERONREF:0000006 @@ -275334,7 +275776,7 @@ plexiform layer using GABA. Origin: abdominal aorta; branches, inferior pancreaticoduodenal, jejunal, ileal, ileocolic, right colic, and middle colic arteries; distribution: small intestine, proximal half of colon - BTO + BTO @@ -278966,7 +279408,7 @@ plexiform layer using GABA. 2012-11-28 XAO:0000146 XAO - XAO:curator + XAO:curator @@ -281424,7 +281866,7 @@ plexiform layer using GABA. - BTO + BTO @@ -288785,7 +289227,7 @@ plexiform layer using GABA. 2012-08-14 VSAO:0000027 VSAO - GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 + GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 PSPUB:0000170 @@ -289117,7 +289559,7 @@ plexiform layer using GABA. 2012-06-20 AAO:0000742 AAO - AAO:Pugener_2002 + AAO:Pugener_2002 @@ -290123,7 +290565,7 @@ plexiform layer using GABA. ossa tarsalia - FMA:71339 + FMA:71339 FMA:TA @@ -290131,7 +290573,7 @@ plexiform layer using GABA. ossa tarsi - FMA:71339 + FMA:71339 FMA:TA @@ -297028,7 +297470,7 @@ plexiform layer using GABA. Nerve that carries information from the olfactory epithelium to the olfactory bulb[Butler and Hodos]. - ISBN:0471209627 + ISBN:0471209627 @@ -297059,14 +297501,14 @@ plexiform layer using GABA. VHOG:0000703 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 1n BIRNLEX:1319 - NIFSTD:NeuroNames_abbrevSource + NIFSTD:NeuroNames_abbrevSource @@ -297856,7 +298298,7 @@ plexiform layer using GABA. - BTO + BTO @@ -298071,7 +298513,7 @@ plexiform layer using GABA. - BTO + BTO @@ -299568,7 +300010,7 @@ plexiform layer using GABA. Cranial nerve that has three branches - the ophthalmic (supplying the skin of the nose and upper jaw), the maxillary and the mandibular (supplying the lower jaw). - ISBN:0471209627 + ISBN:0471209627 @@ -299587,7 +300029,7 @@ plexiform layer using GABA. VHOG:0000704 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 @@ -299600,7 +300042,7 @@ plexiform layer using GABA. 5n BIRNLEX:869 - NIFSTD:NeuroNames_abbrevSource + NIFSTD:NeuroNames_abbrevSource @@ -299807,7 +300249,7 @@ plexiform layer using GABA. Cranial nerve that branches into the supraorbital (supplying the skin of the eye region and the lateral line organs here), the palatine (to the roof of the buccal cavity), and the hyomandibular (dividing into the jugular and mental branches). - ISBN:0471209627 + ISBN:0471209627 @@ -299826,14 +300268,14 @@ plexiform layer using GABA. VHOG:0000706 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 7n BIRNLEX:827 - NIFSTD:NeuroNames_abbrevSource + NIFSTD:NeuroNames_abbrevSource @@ -300034,7 +300476,7 @@ plexiform layer using GABA. Cranial nerve that transmits sound and equilibrium (balance) information from the inner ear to the brain. - ISBN:0471209627 + ISBN:0471209627 @@ -300053,14 +300495,14 @@ plexiform layer using GABA. VHOG:0000695 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 8n BIRNLEX:890 - NIFSTD:NeuroNames_abbrevSource + NIFSTD:NeuroNames_abbrevSource @@ -300227,7 +300669,7 @@ plexiform layer using GABA. Cranial nerve that branches into the ramus communicans (to the skin), the pretrematic (to the walls of the pharynx and mouth, viscero-sensory fibers), and the larval post-trematic branch (lost in the adult). - ISBN:0471209627 + ISBN:0471209627 @@ -300246,14 +300688,14 @@ plexiform layer using GABA. VHOG:0000701 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 9n BIRNLEX:899 - NIFSTD:NeuroNames_abbrevSource + NIFSTD:NeuroNames_abbrevSource @@ -300459,7 +300901,7 @@ plexiform layer using GABA. 12n BIRNLEX:820 - NIFSTD:NeuroNames_abbrevSource + NIFSTD:NeuroNames_abbrevSource @@ -302220,7 +302662,7 @@ plexiform layer using GABA. in XAO this includes and is only the tympanum - XAO + XAO @@ -303691,7 +304133,7 @@ plexiform layer using GABA. - BTO + BTO EHDAA2 FMA ZFA @@ -304853,7 +305295,7 @@ plexiform layer using GABA. parenchyma of thyroid - OBOL:accepted + OBOL:accepted @@ -304883,7 +305325,7 @@ plexiform layer using GABA. thyroid parenchyma - OBOL:accepted + OBOL:accepted @@ -305103,7 +305545,7 @@ plexiform layer using GABA. - ISBN:0781772214 + ISBN:0781772214 @@ -306004,7 +306446,7 @@ plexiform layer using GABA. Cranial nerve that branches into the lateral (to body sense organs) and the intestino-accessorial (to the skin, muscles of shoulder, hyoid, larynx, gut, lungs, and heart). - ISBN:0471209627 + ISBN:0471209627 @@ -306023,14 +306465,14 @@ plexiform layer using GABA. VHOG:0000737 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 10n BIRNLEX:801 - NIFSTD:NeuroNames_abbrevSource + NIFSTD:NeuroNames_abbrevSource @@ -307628,7 +308070,7 @@ plexiform layer using GABA. cjm - ISBN:0781772214 + ISBN:0781772214 Wikipedia @@ -309568,7 +310010,7 @@ plexiform layer using GABA. FMA def states A and P located_in in EHDAA2 - VHOG + VHOG @@ -309582,7 +310024,7 @@ plexiform layer using GABA. The fluid produced by the ciliary process in the eye and occupying the anterior and posterior chambers. It provides nourishment for the lens and cornea and maintains the ocular pressure, and hence the optical integrity of the eyeball. [TFD][VHOG] 2012-09-17 VHOG:0000548 - VHOG + VHOG @@ -309592,7 +310034,7 @@ plexiform layer using GABA. (...) we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya (reference 1); Although the eye varies greatly in adaptative details among vertebrates, its basic structure is the same in all. The human eye is representative of the design typical for a tetrapod. (...) A watery aqueous humor fills the spaces in the eye in front of the lens (...) (reference 2).[well established][VHOG] 2012-09-17 VHOG:0000548 - VHOG + VHOG DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007), ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.424 and p.426 and p.429 and Figure 12-24 @@ -312197,9 +312639,9 @@ plexiform layer using GABA. - BTO + BTO FMA-implicit - VHOG + VHOG ZFA @@ -314242,7 +314684,7 @@ plexiform layer using GABA. - FMA-abduced-lr + FMA-abduced-lr @@ -314988,7 +315430,7 @@ plexiform layer using GABA. FB BIRNLEX:1509 - NIFSTD:NeuroNames_abbrevSource + NIFSTD:NeuroNames_abbrevSource @@ -315159,7 +315601,7 @@ plexiform layer using GABA. MB BIRNLEX:1667 - NIFSTD:NeuroNames_abbrevSource + NIFSTD:NeuroNames_abbrevSource @@ -315692,7 +316134,7 @@ plexiform layer using GABA. DiE BIRNLEX:1503 - NIFSTD:NeuroNames_abbrevSource + NIFSTD:NeuroNames_abbrevSource @@ -316129,7 +316571,7 @@ plexiform layer using GABA. - FMA-abduced-lr + FMA-abduced-lr @@ -316172,7 +316614,7 @@ plexiform layer using GABA. Th BIRNLEX:954 - NIFSTD:NeuroNames_abbrevSource + NIFSTD:NeuroNames_abbrevSource @@ -316379,7 +316821,7 @@ plexiform layer using GABA. Hy BIRNLEX:734 - NIFSTD:NeuroNames_abbrevSource + NIFSTD:NeuroNames_abbrevSource @@ -316517,7 +316959,7 @@ plexiform layer using GABA. ETh BIRNLEX:1710 - NIFSTD:NeuroNames_abbrevSource + NIFSTD:NeuroNames_abbrevSource @@ -316920,7 +317362,7 @@ plexiform layer using GABA. Pi BIRNLEX:1184 - NIFSTD:NeuroNames_abbrevSource + NIFSTD:NeuroNames_abbrevSource @@ -317869,7 +318311,7 @@ plexiform layer using GABA. Pa BIRNLEX:1407 - NIFSTD:NeuroNames_abbrevSource + NIFSTD:NeuroNames_abbrevSource @@ -318047,7 +318489,7 @@ plexiform layer using GABA. MTg BIRNLEX:1200 - NIFSTD:NeuroNames_abbrevSource + NIFSTD:NeuroNames_abbrevSource @@ -318575,7 +319017,7 @@ plexiform layer using GABA. - ABA + ABA @@ -324469,7 +324911,7 @@ plexiform layer using GABA. Muscle tissue that contains fibers that are divided by transverse bands into striations. CL:0000737 GOC:dph - GOC:mtg_muscle + GOC:mtg_muscle @@ -324820,7 +325262,7 @@ plexiform layer using GABA. SN BIRNLEX:789 - NIFSTD:NeuroNames_abbrevSource + NIFSTD:NeuroNames_abbrevSource @@ -329017,7 +329459,7 @@ plexiform layer using GABA. Organism subdivision which is the part of the body posterior to the cervical region (or head, when cervical region not present) and anterior to the caudal region. Includes the sacrum when present. TAO:0001115 - UBERONREF:0000006 + UBERONREF:0000006 @@ -329826,7 +330268,7 @@ plexiform layer using GABA. - BTO + BTO EHDAA2 GO-def @@ -330216,7 +330658,7 @@ plexiform layer using GABA. - BTO + BTO @@ -331292,7 +331734,7 @@ plexiform layer using GABA. 2012-06-20 AAO:0011089 AAO - XAO:curator + XAO:curator @@ -333602,7 +334044,7 @@ plexiform layer using GABA. VHOG:0000141 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.510 and Figure 15-5 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.510 and Figure 15-5 @@ -333615,7 +334057,7 @@ plexiform layer using GABA. AHP BIRNLEX:1581 - NIFSTD:NeuroNames_abbrevSource + NIFSTD:NeuroNames_abbrevSource @@ -333847,7 +334289,7 @@ plexiform layer using GABA. VHOG:0000142 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.510 and Figure 15-5 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.510 and Figure 15-5 @@ -333860,7 +334302,7 @@ plexiform layer using GABA. NHP BIRNLEX:1586 - NIFSTD:NeuroNames_abbrevSource + NIFSTD:NeuroNames_abbrevSource @@ -334661,7 +335103,7 @@ plexiform layer using GABA. - ABA + ABA @@ -334691,7 +335133,7 @@ plexiform layer using GABA. MMB BIRNLEX:865 - NIFSTD:NeuroNames_abbrevSource + NIFSTD:NeuroNames_abbrevSource @@ -335782,7 +336224,7 @@ plexiform layer using GABA. 2012-06-20 AAO:0000545 AAO - AAO:Pugener_2002 + AAO:Pugener_2002 @@ -336762,7 +337204,7 @@ plexiform layer using GABA. - FMA-abduced-lr + FMA-abduced-lr @@ -339337,13 +339779,13 @@ plexiform layer using GABA. fimbria (Vieussens) - NeuroNames:187 + NeuroNames:187 fimbria fornicis - NeuroNames:187 + NeuroNames:187 @@ -339357,20 +339799,20 @@ plexiform layer using GABA. fimbria hippocampi - NeuroNames:187 + NeuroNames:187 fimbria of fornix - NeuroNames:187 + NeuroNames:187 fimbria of the hippocampus - NeuroNames:187 + NeuroNames:187 @@ -341471,7 +341913,7 @@ plexiform layer using GABA. - BTO + BTO @@ -345384,7 +345826,7 @@ plexiform layer using GABA. The middle limb segment of the pectoral free limb, between the autopod and stylopod segments. Includes as parts the forelimb zeugopodial skeleton, which includes as parts the radius and ulna, or their cartilage precursors, or evolutionary variants. - PHENOSCAPE:curators + PHENOSCAPE:curators @@ -348013,7 +348455,7 @@ plexiform layer using GABA. 2012-08-14 VSAO:0000040 VSAO - GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 + GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 PSPUB:0000170 @@ -349249,7 +349691,7 @@ plexiform layer using GABA. - BTO + BTO @@ -350879,7 +351321,7 @@ plexiform layer using GABA. The middle free limb segment, between the autopod and stylopod segments. Includes as parts the zeugopodial skeleton. Examples: There are two types of zeugopod: forelimb zeugopod (aka forearm), hindlimb zeugopod (aka crus). - PHENOSCAPE:curators + PHENOSCAPE:curators @@ -351313,7 +351755,7 @@ plexiform layer using GABA. 2012-08-14 VSAO:0000047 VSAO - GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 + GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 PSPUB:0000170 @@ -352288,7 +352730,7 @@ plexiform layer using GABA. 2012-08-14 VSAO:0000145 VSAO - GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 + GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 PSPUB:0000170 @@ -353439,7 +353881,7 @@ plexiform layer using GABA. A line of sensory organs and associated structures along the sides of fish and amphibia that detect vibrations and pressure changes. - ISBN:0471209627 + ISBN:0471209627 ISBN:0815318960 @@ -354310,13 +354752,13 @@ plexiform layer using GABA. corticospinal fibers - NeuroNames:1320 + NeuroNames:1320 fasciculus cerebro-spinalis - NeuroNames:1320 + NeuroNames:1320 @@ -354330,7 +354772,7 @@ plexiform layer using GABA. fibrae corticospinales - NeuroNames:1320 + NeuroNames:1320 @@ -354343,7 +354785,7 @@ plexiform layer using GABA. tractus cortico-spinalis - NeuroNames:1320 + NeuroNames:1320 @@ -354357,7 +354799,7 @@ plexiform layer using GABA. tractus corticospinalis - NeuroNames:1320 + NeuroNames:1320 @@ -354622,7 +355064,7 @@ plexiform layer using GABA. - BTO + BTO @@ -354749,7 +355191,7 @@ plexiform layer using GABA. PHR BIRNLEX:1651 - NIFSTD:NeuroNames_abbrevSource + NIFSTD:NeuroNames_abbrevSource @@ -355883,7 +356325,7 @@ plexiform layer using GABA. LF BIRNLEX:4041 - NIFSTD:NeuroNames_abbrevSource + NIFSTD:NeuroNames_abbrevSource @@ -358031,7 +358473,7 @@ plexiform layer using GABA. VHOG:0000297 VHOG - DOI:10.1111/j.1469-7580.2005.00472.x Graham A, Okabe M and Quinlan R, The role of the endoderm in the development and evolution of the pharyngeal arches. J Anat (2005) + DOI:10.1111/j.1469-7580.2005.00472.x Graham A, Okabe M and Quinlan R, The role of the endoderm in the development and evolution of the pharyngeal arches. J Anat (2005) @@ -358727,7 +359169,7 @@ plexiform layer using GABA. - NCBIBook:NBK53175 + NCBIBook:NBK53175 @@ -358759,7 +359201,7 @@ plexiform layer using GABA. Classical transplantation experiments using amphibian embryos suggested that the optic vesicle is the source of lens-inducing signals sufficient to generate lens tissues in competent ectoderm (reviewed in Grainger et al., 1996). More recent findings suggest a multistep model for lens induction. There is now good evidence that lens specification occurs at the neurula stage, before the optic vesicle contact the surface ectoderm, and that neural crest cell migration in the frontonasal region is required to restrict the position of the lens placode (Bailey et al., 2006) - NCBIBook:NBK53175 + NCBIBook:NBK53175 @@ -358902,7 +359344,7 @@ plexiform layer using GABA. Wolffian duct - GOC:yaf + GOC:yaf ZFA:0000546 @@ -359010,7 +359452,7 @@ plexiform layer using GABA. A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA] - ISBN:0815318960 + ISBN:0815318960 OMD:neural+plate ZFIN:curator @@ -359472,7 +359914,7 @@ plexiform layer using GABA. EHDAA2 - VHOG + VHOG @@ -359496,7 +359938,7 @@ plexiform layer using GABA. The portion of the mesoderm of the trunk of vertebrate embryos lying lateral to the intermediate mesoderm. [...] [It] subdivides into two plates: one dorsal, called the somatopleure, and one ventral, called the splanchnopleure. [Gastrulation:_From_cells_to_embryo_(2004)_Cold_Spring_Harbor, Glossary_XV, New_York:_Cold_Spring_Harbor_Laboratory_Press, Stern_CD][VHOG] 2012-09-17 VHOG:0000118 - VHOG + VHOG @@ -359505,7 +359947,7 @@ plexiform layer using GABA. A ventrolateral zone of amphioxus mesoderm grows down to surround the gut. Homology of this zone to the lateral plate mesoderm of vertebrates is supported by site of origin and fate.[well established][VHOG] 2012-09-17 VHOG:0000118 - VHOG + VHOG DOI:10.1073/pnas.97.9.4449 Shimeld SM and Holland PW. Vertebrate innovations. PNAS (2000) @@ -359950,7 +360392,7 @@ plexiform layer using GABA. 2012-06-20 AAO:0011023 AAO - ISBN:0-226-55763-4 + ISBN:0-226-55763-4 @@ -360144,7 +360586,7 @@ plexiform layer using GABA. - VHOG + VHOG @@ -360958,7 +361400,7 @@ plexiform layer using GABA. VHOG:0000298 VHOG - DOI:10.1111/j.1469-7580.2005.00472.x Graham A, Okabe M and Quinlan R, The role of the endoderm in the development and evolution of the pharyngeal arches. J Anat (2005) + DOI:10.1111/j.1469-7580.2005.00472.x Graham A, Okabe M and Quinlan R, The role of the endoderm in the development and evolution of the pharyngeal arches. J Anat (2005) @@ -361070,7 +361512,7 @@ plexiform layer using GABA. VHOG:0000299 VHOG - DOI:10.1111/j.1469-7580.2005.00472.x Graham A, Okabe M and Quinlan R, The role of the endoderm in the development and evolution of the pharyngeal arches. J Anat (2005) + DOI:10.1111/j.1469-7580.2005.00472.x Graham A, Okabe M and Quinlan R, The role of the endoderm in the development and evolution of the pharyngeal arches. J Anat (2005) @@ -363053,7 +363495,7 @@ plexiform layer using GABA. - ISBN:9780878932504 + ISBN:9780878932504 @@ -364314,7 +364756,7 @@ plexiform layer using GABA. EHDAA2 - Wikipathways:WP2062 + Wikipathways:WP2062 @@ -364802,7 +365244,7 @@ plexiform layer using GABA. amnionic ectoderm - ISBN:9780878932504 + ISBN:9780878932504 @@ -366641,7 +367083,7 @@ plexiform layer using GABA. - BTO + BTO @@ -369459,7 +369901,7 @@ plexiform layer using GABA. - BTO + BTO @@ -372688,7 +373130,7 @@ plexiform layer using GABA. hind limb digit nerve - OBOL:accepted + OBOL:accepted @@ -372743,7 +373185,7 @@ plexiform layer using GABA. foot digit nerve NCBITaxon:9606 - OBOL:accepted + OBOL:accepted @@ -377273,7 +377715,7 @@ plexiform layer using GABA. hind limb digit blood vessel - OBOL:accepted + OBOL:accepted @@ -377292,7 +377734,7 @@ plexiform layer using GABA. foot digit blood vessel NCBITaxon:9606 - OBOL:accepted + OBOL:accepted @@ -378146,7 +378588,7 @@ plexiform layer using GABA. hand digit blood vessel NCBITaxon:9606 - OBOL:accepted + OBOL:accepted @@ -378762,7 +379204,7 @@ plexiform layer using GABA. hind limb digit skin - OBOL:accepted + OBOL:accepted @@ -378817,7 +379259,7 @@ plexiform layer using GABA. foot digit skin NCBITaxon:9606 - OBOL:accepted + OBOL:accepted @@ -379102,7 +379544,7 @@ plexiform layer using GABA. fore limb digit skin - OBOL:accepted + OBOL:accepted @@ -379157,7 +379599,7 @@ plexiform layer using GABA. hand digit skin NCBITaxon:9606 - OBOL:accepted + OBOL:accepted @@ -382943,14 +383385,14 @@ plexiform layer using GABA. hind limb digit connective tissue - OBOL:accepted + OBOL:accepted foot digit connective tissue NCBITaxon:9606 - OBOL:accepted + OBOL:accepted @@ -384821,7 +385263,7 @@ plexiform layer using GABA. fore limb digit connective tissue - OBOL:accepted + OBOL:accepted @@ -384834,7 +385276,7 @@ plexiform layer using GABA. hand digit connective tissue NCBITaxon:9606 - OBOL:accepted + OBOL:accepted @@ -387280,7 +387722,7 @@ plexiform layer using GABA. hind limb digit muscle - OBOL:accepted + OBOL:accepted @@ -387335,7 +387777,7 @@ plexiform layer using GABA. foot digit muscle NCBITaxon:9606 - OBOL:accepted + OBOL:accepted @@ -387480,7 +387922,7 @@ plexiform layer using GABA. limb muscle organ - OBOL:accepted + OBOL:accepted @@ -387492,7 +387934,7 @@ plexiform layer using GABA. muscle organ of limb - OBOL:accepted + OBOL:accepted @@ -387854,7 +388296,7 @@ plexiform layer using GABA. fore limb digit muscle - OBOL:accepted + OBOL:accepted @@ -387915,7 +388357,7 @@ plexiform layer using GABA. hand digit muscle NCBITaxon:9606 - OBOL:accepted + OBOL:accepted @@ -390246,19 +390688,19 @@ plexiform layer using GABA. mouth mucous membrane - OBOL:accepted + OBOL:accepted mouth organ mucosa - OBOL:accepted + OBOL:accepted mucosa of mouth - OBOL:accepted + OBOL:accepted @@ -390745,7 +391187,7 @@ plexiform layer using GABA. The middle limb segment of the pelvic free limb, between the autopod and stylopod segments. Includes as parts the hindlimb zeugopodial skeleton, which includes as parts the tibia and fibula, or their cartilage precursors, or evolutionary variants. - PHENOSCAPE:curators + PHENOSCAPE:curators @@ -393764,7 +394206,7 @@ plexiform layer using GABA. 2012-06-20 AAO:0000725 AAO - AAO:Pugener_2002 + AAO:Pugener_2002 @@ -396011,7 +396453,7 @@ plexiform layer using GABA. 2012-06-20 AAO:0011031 AAO - XAO:curator + XAO:curator @@ -396431,13 +396873,13 @@ plexiform layer using GABA. cartilage of chondrocranium - OBOL:accepted + OBOL:accepted cartilaginous element of chondrocranium - OBOL:accepted + OBOL:accepted @@ -398251,7 +398693,7 @@ plexiform layer using GABA. primary spleen B cell follicle - CL:tm + CL:tm @@ -398602,7 +399044,7 @@ plexiform layer using GABA. - BTO + BTO @@ -407960,7 +408402,7 @@ plexiform layer using GABA. hind limb digit bone - OBOL:accepted + OBOL:accepted @@ -407979,7 +408421,7 @@ plexiform layer using GABA. foot digit bone NCBITaxon:9606 - OBOL:accepted + OBOL:accepted @@ -408048,7 +408490,7 @@ plexiform layer using GABA. fore limb digit bone - OBOL:accepted + OBOL:accepted @@ -408061,7 +408503,7 @@ plexiform layer using GABA. hand digit bone NCBITaxon:9606 - OBOL:accepted + OBOL:accepted @@ -410597,7 +411039,7 @@ plexiform layer using GABA. 2012-08-14 VSAO:0000026 VSAO - GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 + GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 @@ -411706,7 +412148,7 @@ plexiform layer using GABA. - ISBN:9780878932504 + ISBN:9780878932504 @@ -411714,7 +412156,7 @@ plexiform layer using GABA. An outgrowth on the lateral trunk of the embryo that develops into a limb. The limb bud is divided into ectoderm and mesenchyme[cjm, modified from MP]. - ISBN:9780878932504 + ISBN:9780878932504 MP:0005650 @@ -412182,7 +412624,7 @@ plexiform layer using GABA. One of a series of paired embryological vascular structures formed within a pharyngeal arch; in the adult, some of these vessels give rise to the great vessels[MP] - MP:0002672 + MP:0002672 @@ -412214,7 +412656,7 @@ plexiform layer using GABA. PAA - MP:0002672 + MP:0002672 @@ -412248,13 +412690,13 @@ plexiform layer using GABA. embryonic aortic arch artery EMAPA:16684 - MP:0002672 + MP:0002672 pharyngeal arch artery - MP:0002672 + MP:0002672 @@ -412991,7 +413433,7 @@ plexiform layer using GABA. 2012-08-14 VSAO:0000300 VSAO - GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 + GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 @@ -423310,7 +423752,7 @@ plexiform layer using GABA. VSAO:0000015 taken from version of VSAO used in TAO and used directly in Uberon VSAO - GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 + GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 PSPUB:0000170 @@ -429787,7 +430229,7 @@ plexiform layer using GABA. parietal mesoderm - ISBN:9780878932504 + ISBN:9780878932504 @@ -429848,7 +430290,7 @@ plexiform layer using GABA. splanchnic mesoderm - ISBN:9780878932504 + ISBN:9780878932504 @@ -430159,7 +430601,7 @@ plexiform layer using GABA. - BTO + BTO @@ -440533,7 +440975,7 @@ plexiform layer using GABA. - Wikipathways:WP2062 + Wikipathways:WP2062 @@ -440740,7 +441182,7 @@ plexiform layer using GABA. - Wikipathways:WP2062 + Wikipathways:WP2062 @@ -440800,7 +441242,7 @@ plexiform layer using GABA. - Wikipathways:WP2062 + Wikipathways:WP2062 @@ -442280,7 +442722,7 @@ plexiform layer using GABA. - ISBN:9780878932504 + ISBN:9780878932504 @@ -443987,7 +444429,7 @@ plexiform layer using GABA. - BTO + BTO @@ -445107,14 +445549,14 @@ plexiform layer using GABA. hind limb digit epithelium - OBOL:accepted + OBOL:accepted foot digit epithelium NCBITaxon:9606 - OBOL:accepted + OBOL:accepted @@ -445180,14 +445622,14 @@ plexiform layer using GABA. fore limb digit epithelium - OBOL:accepted + OBOL:accepted hand digit epithelium NCBITaxon:9606 - OBOL:accepted + OBOL:accepted @@ -445885,14 +446327,14 @@ plexiform layer using GABA. hind limb digit mesenchyme - OBOL:accepted + OBOL:accepted foot digit mesenchyme NCBITaxon:9606 - OBOL:accepted + OBOL:accepted @@ -446037,14 +446479,14 @@ plexiform layer using GABA. fore limb digit mesenchyme - OBOL:accepted + OBOL:accepted hand digit mesenchyme NCBITaxon:9606 - OBOL:accepted + OBOL:accepted @@ -448969,7 +449411,7 @@ plexiform layer using GABA. Layer that is part of the CA fields of the hippocampus consisting of a narrow relatively cell free layer located deep to the pyramidal cell layer extending through areas CA1, CA2 and CA3. (adapted from Paxinos The rat central nervous system, 2nd ed, Academic Press, San Diego, 1995) BAMS:Or - BIRNLEX:4113 + BIRNLEX:4113 EMAPA:35412 FMA:83893 MA:0000958 @@ -448990,43 +449432,43 @@ plexiform layer using GABA. Layer that is part of the CA fields of the hippocampus consisting of a narrow relatively cell free layer located deep to the pyramidal cell layer extending through areas CA1, CA2 and CA3. (adapted from Paxinos The rat central nervous system, 2nd ed, Academic Press, San Diego, 1995) - BIRNLEX:4113 + BIRNLEX:4113 http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=157 - BIRNLEX:4113 + BIRNLEX:4113 oriens layer of hippocampus - BIRNLEX:4113 + BIRNLEX:4113 oriens layer of the hippocampus - BIRNLEX:4113 + BIRNLEX:4113 polymorphic layer of hippocampus - BIRNLEX:4113 + BIRNLEX:4113 polymorphic layer of the hippocampus - BIRNLEX:4113 + BIRNLEX:4113 stratum oriens - BIRNLEX:4113 + BIRNLEX:4113 @@ -451474,7 +451916,7 @@ plexiform layer using GABA. 2012-06-20 AAO:0010382 AAO - XAO:curator + XAO:curator @@ -455018,7 +455460,7 @@ plexiform layer using GABA. we place the XAO structure here for now. In terms of analagy, it is more closely related to common iliac, but the relationships currently attached to this class are mammal specific - XAO + XAO @@ -457109,7 +457551,7 @@ plexiform layer using GABA. 2012-06-20 AAO:0011090 AAO - XAO:curator + XAO:curator @@ -457439,14 +457881,14 @@ plexiform layer using GABA. - ISBN:9780878932504 + ISBN:9780878932504 ZFA-inferred A ring of cells capable of forming a limb or paired fin[Gilbert,modified]. - ISBN:9780878932504 + ISBN:9780878932504 @@ -457483,7 +457925,7 @@ plexiform layer using GABA. A ring of cells capable of forming a limb. - ISBN:9780878932504 + ISBN:9780878932504 @@ -463669,7 +464111,7 @@ plexiform layer using GABA. 2012-06-20 AAO:0000092 AAO - AAO:Duellman_and_Trueb_1994 + AAO:Duellman_and_Trueb_1994 @@ -463795,7 +464237,7 @@ plexiform layer using GABA. 2012-06-20 AAO:0000612 AAO - AAO:Duellman_and_Trueb_1994 + AAO:Duellman_and_Trueb_1994 @@ -463883,7 +464325,7 @@ plexiform layer using GABA. Subdivision of vertebral column that corresponds to the caudal subdivision of the body, containing the caudal vertebrae. - UBERONREF:0000006 + UBERONREF:0000006 @@ -463892,7 +464334,7 @@ plexiform layer using GABA. 2012-06-20 AAO:0000082 AAO - AAO:Duellman_and_Trueb_1994 + AAO:Duellman_and_Trueb_1994 @@ -463910,7 +464352,7 @@ plexiform layer using GABA. caudal skeleton - UBERONREF:0000006 + UBERONREF:0000006 @@ -469836,7 +470278,7 @@ plexiform layer using GABA. - FMA-abduced + FMA-abduced @@ -472089,7 +472531,7 @@ plexiform layer using GABA. 2012-08-14 VSAO:0005019 VSAO - VSAO:NI + VSAO:NI @@ -472120,7 +472562,7 @@ plexiform layer using GABA. autopodium VSAO:0005019 - VSAO:NI + VSAO:NI @@ -472651,7 +473093,7 @@ plexiform layer using GABA. - BTO + BTO @@ -476006,14 +476448,14 @@ plexiform layer using GABA. VHOG:0000244 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.510 and Figure 15-5 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.510 and Figure 15-5 DHP BIRNLEX:1022 - NIFSTD:NeuroNames_abbrevSource + NIFSTD:NeuroNames_abbrevSource @@ -477136,7 +477578,7 @@ plexiform layer using GABA. 2012-06-20 AAO:0011115 AAO - ISBN:0-226-55763-4 + ISBN:0-226-55763-4 @@ -477146,7 +477588,7 @@ plexiform layer using GABA. VHOG:0000967 VHOG - DOI:10.1111/j.1469-7580.2005.00472.x Graham A, Okabe M and Quinlan R, The role of the endoderm in the development and evolution of the pharyngeal arches. J Anat (2005) + DOI:10.1111/j.1469-7580.2005.00472.x Graham A, Okabe M and Quinlan R, The role of the endoderm in the development and evolution of the pharyngeal arches. J Anat (2005) @@ -477331,7 +477773,7 @@ plexiform layer using GABA. 2012-06-20 AAO:0011116 AAO - ISBN:0-226-55763-4 + ISBN:0-226-55763-4 @@ -477341,7 +477783,7 @@ plexiform layer using GABA. VHOG:0000966 VHOG - DOI:10.1111/j.1469-7580.2005.00472.x Graham A, Okabe M and Quinlan R, The role of the endoderm in the development and evolution of the pharyngeal arches. J Anat (2005) + DOI:10.1111/j.1469-7580.2005.00472.x Graham A, Okabe M and Quinlan R, The role of the endoderm in the development and evolution of the pharyngeal arches. J Anat (2005) @@ -480950,13 +481392,13 @@ plexiform layer using GABA. duct of pancreas - OBOL:accepted + OBOL:accepted pancreas duct - OBOL:accepted + OBOL:accepted @@ -482239,7 +482681,7 @@ plexiform layer using GABA. - BTO + BTO @@ -483323,7 +483765,7 @@ plexiform layer using GABA. - VHOG + VHOG @@ -484079,7 +484521,7 @@ plexiform layer using GABA. - BTO + BTO @@ -484126,7 +484568,7 @@ plexiform layer using GABA. - BTO + BTO @@ -485418,7 +485860,7 @@ plexiform layer using GABA. 2012-08-14 VSAO:0000023 VSAO - GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 + GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 PSPUB:0000170 @@ -485649,7 +486091,7 @@ plexiform layer using GABA. 2012-08-14 VSAO:0000050 VSAO - GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 + GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 PSPUB:0000170 @@ -486700,7 +487142,7 @@ plexiform layer using GABA. - BTO + BTO @@ -487077,7 +487519,7 @@ plexiform layer using GABA. - BTO + BTO @@ -487505,7 +487947,7 @@ plexiform layer using GABA. - BTO + BTO @@ -489841,7 +490283,7 @@ plexiform layer using GABA. 2012-08-14 VSAO:0000046 VSAO - GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 + GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 PSPUB:0000170 @@ -490834,7 +491276,7 @@ plexiform layer using GABA. A retinal neural layer that is immediately adjacent to the inner nuclear layer and comprises 20 percent of the inner plexiform layer of retina. - GOC:tfm + GOC:tfm @@ -490885,7 +491327,7 @@ plexiform layer using GABA. A retinal neural layer that is immediately adjacent to the S1 and S3 layers and comprises 20 percent of the inner plexiform layer of retina. - GOC:tfm + GOC:tfm @@ -490937,7 +491379,7 @@ plexiform layer using GABA. A retinal neural layer that is immediately adjacent to the S2 and S4 layers and comprises 20 percent of the inner plexiform layer of retina. - GOC:tfm + GOC:tfm @@ -490988,7 +491430,7 @@ plexiform layer using GABA. A retinal neural layer that is immediately adjacent to the S3 and S5 layer and comprises 20 percent of the inner plexiform layer of retina. - GOC:tfm + GOC:tfm @@ -491036,7 +491478,7 @@ plexiform layer using GABA. A retinal neural layer that is immediately adjacent to the retinal ganglion cell layer and comprises 20 percent of the ganglion plexiform layer of retina. - GOC:tfm + GOC:tfm @@ -491072,7 +491514,7 @@ plexiform layer using GABA. One of sublaminar layers S1 or S2. - GOC:tfm + GOC:tfm @@ -491108,7 +491550,7 @@ plexiform layer using GABA. One of sublaminar layers S2 or S3. - GOC:tfm + GOC:tfm @@ -491144,7 +491586,7 @@ plexiform layer using GABA. One of sublaminar layers S4 or S5. - GOC:tfm + GOC:tfm @@ -495629,7 +496071,7 @@ plexiform layer using GABA. Subdivision of vertebral column that corresponds to the trunk of the body, containing the trunk/presacral vertebrae. In organisms that have a thoracic and lumbar distinction, this corresponds to the sum of both of these regions. - UBERONREF:0000006 + UBERONREF:0000006 @@ -495638,7 +496080,7 @@ plexiform layer using GABA. 2012-06-20 AAO:0000612 AAO - AAO:Duellman_and_Trueb_1994 + AAO:Duellman_and_Trueb_1994 @@ -500040,7 +500482,7 @@ plexiform layer using GABA. 2012-08-14 VSAO:0005022 VSAO - VSAO:NI + VSAO:NI @@ -500055,7 +500497,7 @@ plexiform layer using GABA. basipodium skeleton VSAO:0005022 - VSAO:NI + VSAO:NI @@ -500080,14 +500522,14 @@ plexiform layer using GABA. basipodium VSAO:0005022 - VSAO:NI + VSAO:NI mesopodium VSAO:0005022 - VSAO:NI + VSAO:NI @@ -502121,7 +502563,7 @@ plexiform layer using GABA. one of the gastric glands that secretes the hydrochloric acid of the gastric juice[Stedman's]. - MP:0003892 + MP:0003892 @@ -502133,7 +502575,7 @@ plexiform layer using GABA. gastric gland - MP:0003892 + MP:0003892 @@ -502169,13 +502611,13 @@ plexiform layer using GABA. Wassman gland - MP:0003892 + MP:0003892 gastric follicle - MP:0003892 + MP:0003892 @@ -504660,7 +505102,7 @@ plexiform layer using GABA. - BTO + BTO @@ -511540,7 +511982,7 @@ plexiform layer using GABA. 2012-08-14 VSAO:0005025 VSAO - VSAO:NI + VSAO:NI @@ -511581,7 +512023,7 @@ plexiform layer using GABA. metapodium VSAO:0005025 - VSAO:NI + VSAO:NI @@ -511631,14 +512073,14 @@ plexiform layer using GABA. hind limb digit phalanx pre-cartilage condensation - OBOL:accepted + OBOL:accepted foot digit phalanx pre-cartilage condensation NCBITaxon:9606 - OBOL:accepted + OBOL:accepted @@ -511683,7 +512125,7 @@ plexiform layer using GABA. fore limb digit phalanx pre-cartilage condensation - OBOL:accepted + OBOL:accepted @@ -511696,7 +512138,7 @@ plexiform layer using GABA. hand digit phalanx pre-cartilage condensation NCBITaxon:9606 - OBOL:accepted + OBOL:accepted @@ -511743,14 +512185,14 @@ plexiform layer using GABA. hind limb digit phalanx cartilage condensation - OBOL:accepted + OBOL:accepted foot digit phalanx cartilage element NCBITaxon:9606 - OBOL:accepted + OBOL:accepted @@ -511797,14 +512239,14 @@ plexiform layer using GABA. fore limb digit phalanx cartilage condensation - OBOL:accepted + OBOL:accepted hand digit phalanx cartilage condensation NCBITaxon:9606 - OBOL:accepted + OBOL:accepted @@ -511844,7 +512286,7 @@ plexiform layer using GABA. hind limb digit metatarsal pre-cartilage condensation - OBOL:accepted + OBOL:accepted @@ -511857,7 +512299,7 @@ plexiform layer using GABA. foot digit metatarsal pre-cartilage condensation NCBITaxon:9606 - OBOL:accepted + OBOL:accepted @@ -512141,14 +512583,14 @@ plexiform layer using GABA. hind limb digit metatarsal cartilage condensation - OBOL:accepted + OBOL:accepted foot digit metatarsal cartilage condensation NCBITaxon:9606 - OBOL:accepted + OBOL:accepted @@ -512191,7 +512633,7 @@ plexiform layer using GABA. fore limb digit metacarpus pre-cartilage condensation - OBOL:accepted + OBOL:accepted @@ -512210,7 +512652,7 @@ plexiform layer using GABA. hand digit metacarpus pre-cartilage condensation NCBITaxon:9606 - OBOL:accepted + OBOL:accepted @@ -512253,14 +512695,14 @@ plexiform layer using GABA. fore limb digit metacarpus cartilage element - OBOL:accepted + OBOL:accepted hand digit metacarpus cartilage element NCBITaxon:9606 - OBOL:accepted + OBOL:accepted @@ -512477,7 +512919,7 @@ plexiform layer using GABA. antebrachium skeleton - PHENOSCAPE:ni + PHENOSCAPE:ni @@ -512531,7 +512973,7 @@ plexiform layer using GABA. mesomere 2 of pectoral appendage - ISBN:0226313409 + ISBN:0226313409 @@ -512582,7 +513024,7 @@ plexiform layer using GABA. 2012-08-14 VSAO:0000214 VSAO - GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 + GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 @@ -512984,7 +513426,7 @@ plexiform layer using GABA. 2012-08-14 VSAO:0000302 VSAO - GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 + GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 @@ -513086,13 +513528,13 @@ plexiform layer using GABA. crus skeleton - PHENOSCAPE:ni + PHENOSCAPE:ni skeleton cruris - NominaAnatomicaVeterinaria:2005 + NominaAnatomicaVeterinaria:2005 @@ -513112,7 +513554,7 @@ plexiform layer using GABA. mesomere 2 of pelvic appendage - ISBN:0226313409 + ISBN:0226313409 @@ -518227,7 +518669,7 @@ plexiform layer using GABA. The part of the trunk that is in the dorsum[cjm]. - UBERONREF:0000006 + UBERONREF:0000006 @@ -519038,7 +519480,7 @@ plexiform layer using GABA. - ISBN:9780878932504 + ISBN:9780878932504 @@ -519053,7 +519495,7 @@ plexiform layer using GABA. 2012-08-14 VSAO:0000301 VSAO - GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 + GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 @@ -519138,13 +519580,13 @@ plexiform layer using GABA. 2012-08-14 VSAO:0005007 VSAO - VSAO:NI + VSAO:NI mesomere 1 - ISBN:0226313409 + ISBN:0226313409 @@ -519157,7 +519599,7 @@ plexiform layer using GABA. proximal metapterygial mesomere - ISBN:0226313409 + ISBN:0226313409 @@ -519263,14 +519705,14 @@ plexiform layer using GABA. mesomere 2 - ISBN:0226313409 + ISBN:0226313409 mesomere 2 skeleton - ISBN:0226313409 + ISBN:0226313409 @@ -523260,7 +523702,7 @@ plexiform layer using GABA. A segment of the autopod consisting of both acropodial region and metapodial region, but excluding the mesopodial/basopodial region. - PHENOSCAPE:ni + PHENOSCAPE:ni @@ -523388,13 +523830,13 @@ plexiform layer using GABA. A subdivision of the autopod skeleton consisting of both acropodial skeleon and metapodial skeleton, but excluding the mesopodial/basopodial skeleton. - PHENOSCAPE:ni + PHENOSCAPE:ni digitopodium - PHENOSCAPE:ni + PHENOSCAPE:ni @@ -523456,7 +523898,7 @@ plexiform layer using GABA. A subdivision of the manus skeleton consisting of both manual acropodial skeleton and metacarpal skeleton, but excluding the carpal skeleton. - PHENOSCAPE:ni + PHENOSCAPE:ni @@ -523501,7 +523943,7 @@ plexiform layer using GABA. A subdivision of the pes skeleton consisting of both pedal acropodial skeleton and metatarsal skeleton, but excluding the tarsal skeleton. - PHENOSCAPE:ni + PHENOSCAPE:ni @@ -524360,7 +524802,7 @@ plexiform layer using GABA. - BTO + BTO @@ -525480,7 +525922,7 @@ plexiform layer using GABA. - MESH + MESH @@ -533956,41 +534398,41 @@ plexiform layer using GABA. isthmus cinguli - NeuroNames:163 + NeuroNames:163 isthmus gyri cingulatus - NeuroNames:163 + NeuroNames:163 isthmus gyri cinguli - NeuroNames:163 + NeuroNames:163 isthmus of gyrus fornicatus - NeuroNames:163 + NeuroNames:163 isthmus of the cingulate gyrus - NeuroNames:163 + NeuroNames:163 isthmus-2 - NeuroNames:163 + NeuroNames:163 @@ -534296,7 +534738,7 @@ plexiform layer using GABA. c11n BIRNLEX:1580 - NIFSTD:NeuroNames_abbrevSource + NIFSTD:NeuroNames_abbrevSource @@ -534911,7 +535353,7 @@ plexiform layer using GABA. - VHOG + VHOG @@ -536695,7 +537137,7 @@ plexiform layer using GABA. The major preaxial endochondral element in the posterior zeugopod[Phenoscape]. - PHENOSCAPE:mah + PHENOSCAPE:mah @@ -556658,7 +557100,7 @@ plexiform layer using GABA. A collection of hairs that grows on the external ear. - UBERON:EJS + UBERON:EJS @@ -556708,7 +557150,7 @@ plexiform layer using GABA. A zone of skin that is part of the face. - UBERON:EJS + UBERON:EJS @@ -557706,7 +558148,7 @@ plexiform layer using GABA. Dermal, epidermal, glandular and pigment structures of the body integument. - AAO:EJS + AAO:EJS @@ -557742,7 +558184,7 @@ plexiform layer using GABA. Dermal, epidermal, glandular and pigment structures of the limb integument. - AAO:EJS + AAO:EJS @@ -557778,7 +558220,7 @@ plexiform layer using GABA. Dermal, epidermal, glandular and pigment structures of the tail integument. - AAO:EJS + AAO:EJS @@ -559494,7 +559936,7 @@ plexiform layer using GABA. A protein coding gene BCL6 in human. - PRO:DNx + PRO:DNx @@ -559519,7 +559961,7 @@ plexiform layer using GABA. A protein coding gene RNASE2 in human. - PRO:DNx + PRO:DNx @@ -559544,7 +559986,7 @@ plexiform layer using GABA. A protein coding gene RNASE3 in human. - PRO:DNx + PRO:DNx @@ -559569,7 +560011,7 @@ plexiform layer using GABA. A protein coding gene RORC in human. - PRO:DNx + PRO:DNx @@ -559594,7 +560036,7 @@ plexiform layer using GABA. A protein coding gene RUNX1 in human. - PRO:DNx + PRO:DNx @@ -559619,7 +560061,7 @@ plexiform layer using GABA. A protein coding gene CXCR5 in human. - PRO:DNx + PRO:DNx @@ -559644,7 +560086,7 @@ plexiform layer using GABA. A protein coding gene SDC1 in human. - PRO:DNx + PRO:DNx @@ -559669,7 +560111,7 @@ plexiform layer using GABA. A protein coding gene SELL in human. - PRO:DNx + PRO:DNx @@ -559694,7 +560136,7 @@ plexiform layer using GABA. A protein coding gene SIGLEC5 in human. - PRO:DNx + PRO:DNx @@ -559719,7 +560161,7 @@ plexiform layer using GABA. A protein coding gene SLAMF1 in human. - PRO:DNx + PRO:DNx @@ -559744,7 +560186,7 @@ plexiform layer using GABA. A protein coding gene SIGLEC1 in human. - PRO:DNx + PRO:DNx @@ -559769,7 +560211,7 @@ plexiform layer using GABA. A protein coding gene SNCG in human. - PRO:DNx + PRO:DNx @@ -559794,7 +560236,7 @@ plexiform layer using GABA. A protein coding gene BST2 in human. - PRO:DNx + PRO:DNx @@ -559819,7 +560261,7 @@ plexiform layer using GABA. A protein coding gene SPI1 in human. - PRO:DNx + PRO:DNx @@ -559844,7 +560286,7 @@ plexiform layer using GABA. A protein coding gene SPN in human. - PRO:DNx + PRO:DNx @@ -559869,7 +560311,7 @@ plexiform layer using GABA. A protein coding gene SST in human. - PRO:DNx + PRO:DNx @@ -559894,7 +560336,7 @@ plexiform layer using GABA. A protein coding gene TAL1 in human. - PRO:DNx + PRO:DNx @@ -559919,7 +560361,7 @@ plexiform layer using GABA. A protein coding gene TBX21 in human. - PRO:DNx + PRO:DNx @@ -559944,7 +560386,7 @@ plexiform layer using GABA. A protein coding gene TFRC in human. - PRO:DNx + PRO:DNx @@ -559969,7 +560411,7 @@ plexiform layer using GABA. A protein coding gene THBD in human. - PRO:DNx + PRO:DNx @@ -559994,7 +560436,7 @@ plexiform layer using GABA. A protein coding gene THY1 in human. - PRO:DNx + PRO:DNx @@ -560019,7 +560461,7 @@ plexiform layer using GABA. A protein coding gene TNFRSF11A in human. - PRO:DNx + PRO:DNx @@ -560044,7 +560486,7 @@ plexiform layer using GABA. A protein coding gene CD27 in human. - PRO:DNx + PRO:DNx @@ -560069,7 +560511,7 @@ plexiform layer using GABA. A protein coding gene CD40LG in human. - PRO:DNx + PRO:DNx @@ -560094,7 +560536,7 @@ plexiform layer using GABA. A protein coding gene TRPC3 in human. - PRO:DNx + PRO:DNx @@ -560119,7 +560561,7 @@ plexiform layer using GABA. A protein coding gene ACP5 in human. - PRO:DNx + PRO:DNx @@ -560144,7 +560586,7 @@ plexiform layer using GABA. A protein coding gene VIP in human. - PRO:DNx + PRO:DNx @@ -560169,7 +560611,7 @@ plexiform layer using GABA. A protein coding gene VPREB1 in human. - PRO:DNx + PRO:DNx @@ -560194,7 +560636,7 @@ plexiform layer using GABA. A protein coding gene CLEC4C in human. - PRO:DNx + PRO:DNx @@ -560219,7 +560661,7 @@ plexiform layer using GABA. A protein coding gene NETO1 in human. - PRO:DNx + PRO:DNx @@ -560244,7 +560686,7 @@ plexiform layer using GABA. A protein coding gene CLEC6A in human. - PRO:DNx + PRO:DNx @@ -560269,7 +560711,7 @@ plexiform layer using GABA. A protein coding gene CLEC7A in human. - PRO:DNx + PRO:DNx @@ -560294,7 +560736,7 @@ plexiform layer using GABA. A protein coding gene IRX6 in human. - PRO:DNx + PRO:DNx @@ -560319,7 +560761,7 @@ plexiform layer using GABA. A protein coding gene LILRA4 in human. - PRO:DNx + PRO:DNx @@ -560344,7 +560786,7 @@ plexiform layer using GABA. A protein coding gene CCK in human. - PRO:DNx + PRO:DNx @@ -560369,7 +560811,7 @@ plexiform layer using GABA. A protein coding gene CD93 in human. - PRO:DNx + PRO:DNx @@ -560394,7 +560836,7 @@ plexiform layer using GABA. A protein coding gene CCR1 in human. - PRO:DNx + PRO:DNx @@ -560419,7 +560861,7 @@ plexiform layer using GABA. A protein coding gene CCR2 in human. - PRO:DNx + PRO:DNx @@ -560444,7 +560886,7 @@ plexiform layer using GABA. A protein coding gene CCR3 in human. - PRO:DNx + PRO:DNx @@ -560469,7 +560911,7 @@ plexiform layer using GABA. A protein coding gene CCR4 in human. - PRO:DNx + PRO:DNx @@ -560494,7 +560936,7 @@ plexiform layer using GABA. A protein coding gene CCR5 in human. - PRO:DNx + PRO:DNx @@ -560519,7 +560961,7 @@ plexiform layer using GABA. A protein coding gene CCR6 in human. - PRO:DNx + PRO:DNx @@ -560544,7 +560986,7 @@ plexiform layer using GABA. A protein coding gene CCR7 in human. - PRO:DNx + PRO:DNx @@ -560569,7 +561011,7 @@ plexiform layer using GABA. A protein coding gene LAMP5 in human. - PRO:DNx + PRO:DNx @@ -560594,7 +561036,7 @@ plexiform layer using GABA. A protein coding gene CD14 in human. - PRO:DNx + PRO:DNx @@ -560619,7 +561061,7 @@ plexiform layer using GABA. A protein coding gene CD163 in human. - PRO:DNx + PRO:DNx @@ -560644,7 +561086,7 @@ plexiform layer using GABA. A protein coding gene CD19 in human. - PRO:DNx + PRO:DNx @@ -560669,7 +561111,7 @@ plexiform layer using GABA. A protein coding gene CD1A in human. - PRO:DNx + PRO:DNx @@ -560694,7 +561136,7 @@ plexiform layer using GABA. A protein coding gene CD1C in human. - PRO:DNx + PRO:DNx @@ -560719,7 +561161,7 @@ plexiform layer using GABA. A protein coding gene CD1D in human. - PRO:DNx + PRO:DNx @@ -560744,7 +561186,7 @@ plexiform layer using GABA. A protein coding gene CD2 in human. - PRO:DNx + PRO:DNx @@ -560769,7 +561211,7 @@ plexiform layer using GABA. A protein coding gene CD209 in human. - PRO:DNx + PRO:DNx @@ -560794,7 +561236,7 @@ plexiform layer using GABA. A protein coding gene CD22 in human. - PRO:DNx + PRO:DNx @@ -560819,7 +561261,7 @@ plexiform layer using GABA. A protein coding gene CD24 in human. - PRO:DNx + PRO:DNx @@ -560844,7 +561286,7 @@ plexiform layer using GABA. A protein coding gene CD28 in human. - PRO:DNx + PRO:DNx @@ -560869,7 +561311,7 @@ plexiform layer using GABA. A protein coding gene CD33 in human. - PRO:DNx + PRO:DNx @@ -560894,7 +561336,7 @@ plexiform layer using GABA. A protein coding gene CD34 in human. - PRO:DNx + PRO:DNx @@ -560919,7 +561361,7 @@ plexiform layer using GABA. A protein coding gene CD36 in human. - PRO:DNx + PRO:DNx @@ -560944,7 +561386,7 @@ plexiform layer using GABA. A protein coding gene CD38 in human. - PRO:DNx + PRO:DNx @@ -560969,7 +561411,7 @@ plexiform layer using GABA. A protein coding gene CD3E in human. - PRO:DNx + PRO:DNx @@ -560994,7 +561436,7 @@ plexiform layer using GABA. A protein coding gene CD4 in human. - PRO:DNx + PRO:DNx @@ -561019,7 +561461,7 @@ plexiform layer using GABA. A protein coding gene CD44 in human. - PRO:DNx + PRO:DNx @@ -561044,7 +561486,7 @@ plexiform layer using GABA. A protein coding gene CD48 in human. - PRO:DNx + PRO:DNx @@ -561069,7 +561511,7 @@ plexiform layer using GABA. A protein coding gene CD5 in human. - PRO:DNx + PRO:DNx @@ -561094,7 +561536,7 @@ plexiform layer using GABA. A protein coding gene CD68 in human. - PRO:DNx + PRO:DNx @@ -561119,7 +561561,7 @@ plexiform layer using GABA. A protein coding gene CD69 in human. - PRO:DNx + PRO:DNx @@ -561144,7 +561586,7 @@ plexiform layer using GABA. A protein coding gene CD7 in human. - PRO:DNx + PRO:DNx @@ -561169,7 +561611,7 @@ plexiform layer using GABA. A protein coding gene CD80 in human. - PRO:DNx + PRO:DNx @@ -561194,7 +561636,7 @@ plexiform layer using GABA. A protein coding gene CD83 in human. - PRO:DNx + PRO:DNx @@ -561219,7 +561661,7 @@ plexiform layer using GABA. A protein coding gene CD84 in human. - PRO:DNx + PRO:DNx @@ -561244,7 +561686,7 @@ plexiform layer using GABA. A protein coding gene CD86 in human. - PRO:DNx + PRO:DNx @@ -561269,7 +561711,7 @@ plexiform layer using GABA. A protein coding gene CD8A in human. - PRO:DNx + PRO:DNx @@ -561294,7 +561736,7 @@ plexiform layer using GABA. A protein coding gene CD8B in human. - PRO:DNx + PRO:DNx @@ -561319,7 +561761,7 @@ plexiform layer using GABA. A protein coding gene CD9 in human. - PRO:DNx + PRO:DNx @@ -561344,7 +561786,7 @@ plexiform layer using GABA. A protein coding gene TMED1 in human. - PRO:DNx + PRO:DNx @@ -561369,7 +561811,7 @@ plexiform layer using GABA. A protein coding gene CDH1 in human. - PRO:DNx + PRO:DNx @@ -561394,7 +561836,7 @@ plexiform layer using GABA. A protein coding gene CDH5 in human. - PRO:DNx + PRO:DNx @@ -561419,7 +561861,7 @@ plexiform layer using GABA. A protein coding gene CD207 in human. - PRO:DNx + PRO:DNx @@ -561444,7 +561886,7 @@ plexiform layer using GABA. A protein coding gene IL17RB in human. - PRO:DNx + PRO:DNx @@ -561469,7 +561911,7 @@ plexiform layer using GABA. A protein coding gene A4GALT in human. - PRO:DNx + PRO:DNx @@ -561494,7 +561936,7 @@ plexiform layer using GABA. A protein coding gene CD244 in human. - PRO:DNx + PRO:DNx @@ -561519,7 +561961,7 @@ plexiform layer using GABA. A protein coding gene CEACAM8 in human. - PRO:DNx + PRO:DNx @@ -561544,7 +561986,7 @@ plexiform layer using GABA. A protein coding gene CEBPA in human. - PRO:DNx + PRO:DNx @@ -561569,7 +562011,7 @@ plexiform layer using GABA. A protein coding gene CEBPE in human. - PRO:DNx + PRO:DNx @@ -561594,7 +562036,7 @@ plexiform layer using GABA. A protein coding gene CHRNA7 in human. - PRO:DNx + PRO:DNx @@ -561619,7 +562061,7 @@ plexiform layer using GABA. A protein coding gene COL1A1 in human. - PRO:DNx + PRO:DNx @@ -561644,7 +562086,7 @@ plexiform layer using GABA. A protein coding gene NTNG1 in human. - PRO:DNx + PRO:DNx @@ -561669,7 +562111,7 @@ plexiform layer using GABA. A protein coding gene CR1 in human. - PRO:DNx + PRO:DNx @@ -561694,7 +562136,7 @@ plexiform layer using GABA. A protein coding gene CR2 in human. - PRO:DNx + PRO:DNx @@ -561719,7 +562161,7 @@ plexiform layer using GABA. A protein coding gene CSF1R in human. - PRO:DNx + PRO:DNx @@ -561744,7 +562186,7 @@ plexiform layer using GABA. A protein coding gene CTLA4 in human. - PRO:DNx + PRO:DNx @@ -561769,7 +562211,7 @@ plexiform layer using GABA. A protein coding gene CTSK in human. - PRO:DNx + PRO:DNx @@ -561794,7 +562236,7 @@ plexiform layer using GABA. A protein coding gene CX3CR1 in human. - PRO:DNx + PRO:DNx @@ -561819,7 +562261,7 @@ plexiform layer using GABA. A protein coding gene CXCR4 in human. - PRO:DNx + PRO:DNx @@ -561844,7 +562286,7 @@ plexiform layer using GABA. A protein coding gene DNTT in human. - PRO:DNx + PRO:DNx @@ -561869,7 +562311,7 @@ plexiform layer using GABA. A protein coding gene EGR2 in human. - PRO:DNx + PRO:DNx @@ -561894,7 +562336,7 @@ plexiform layer using GABA. A protein coding gene ADGRE1 in human. - PRO:DNx + PRO:DNx @@ -561919,7 +562361,7 @@ plexiform layer using GABA. A protein coding gene ENG in human. - PRO:DNx + PRO:DNx @@ -561944,7 +562386,7 @@ plexiform layer using GABA. A protein coding gene ENPEP in human. - PRO:DNx + PRO:DNx @@ -561969,7 +562411,7 @@ plexiform layer using GABA. A protein coding gene ENPP3 in human. - PRO:DNx + PRO:DNx @@ -561994,7 +562436,7 @@ plexiform layer using GABA. A protein coding gene EOMES in human. - PRO:DNx + PRO:DNx @@ -562019,7 +562461,7 @@ plexiform layer using GABA. A protein coding gene EPX in human. - PRO:DNx + PRO:DNx @@ -562044,7 +562486,7 @@ plexiform layer using GABA. A protein coding gene FCER1A in human. - PRO:DNx + PRO:DNx @@ -562069,7 +562511,7 @@ plexiform layer using GABA. A protein coding gene FCER2 in human. - PRO:DNx + PRO:DNx @@ -562094,7 +562536,7 @@ plexiform layer using GABA. A protein coding gene FCGR1A in human. - PRO:DNx + PRO:DNx @@ -562119,7 +562561,7 @@ plexiform layer using GABA. A protein coding gene FCGR2B in human. - PRO:DNx + PRO:DNx @@ -562144,7 +562586,7 @@ plexiform layer using GABA. A protein coding gene FLT3 in human. - PRO:DNx + PRO:DNx @@ -562169,7 +562611,7 @@ plexiform layer using GABA. A protein coding gene FOS in human. - PRO:DNx + PRO:DNx @@ -562194,7 +562636,7 @@ plexiform layer using GABA. A protein coding gene FPR1 in human. - PRO:DNx + PRO:DNx @@ -562219,7 +562661,7 @@ plexiform layer using GABA. A protein coding gene FUT4 in human. - PRO:DNx + PRO:DNx @@ -562244,7 +562686,7 @@ plexiform layer using GABA. A protein coding gene GATA1 in human. - PRO:DNx + PRO:DNx @@ -562269,7 +562711,7 @@ plexiform layer using GABA. A protein coding gene GATA2 in human. - PRO:DNx + PRO:DNx @@ -562294,7 +562736,7 @@ plexiform layer using GABA. A protein coding gene GATA3 in human. - PRO:DNx + PRO:DNx @@ -562319,7 +562761,7 @@ plexiform layer using GABA. A protein coding gene GFAP in human. - PRO:DNx + PRO:DNx @@ -562344,7 +562786,7 @@ plexiform layer using GABA. A protein coding gene GP1BA in human. - PRO:DNx + PRO:DNx @@ -562369,7 +562811,7 @@ plexiform layer using GABA. A protein coding gene PTGDR2 in human. - PRO:DNx + PRO:DNx @@ -562394,7 +562836,7 @@ plexiform layer using GABA. A protein coding gene CXCR3 in human. - PRO:DNx + PRO:DNx @@ -562419,7 +562861,7 @@ plexiform layer using GABA. A protein coding gene GYPA in human. - PRO:DNx + PRO:DNx @@ -562444,7 +562886,7 @@ plexiform layer using GABA. A protein coding gene GZMB in human. - PRO:DNx + PRO:DNx @@ -562469,7 +562911,7 @@ plexiform layer using GABA. A protein coding gene HBZ in human. - PRO:DNx + PRO:DNx @@ -562494,7 +562936,7 @@ plexiform layer using GABA. A protein coding gene HLA-DRA in human. - PRO:DNx + PRO:DNx @@ -562519,7 +562961,7 @@ plexiform layer using GABA. A protein coding gene ANPEP in human. - PRO:DNx + PRO:DNx @@ -562544,7 +562986,7 @@ plexiform layer using GABA. A protein coding gene ICOS in human. - PRO:DNx + PRO:DNx @@ -562569,7 +563011,7 @@ plexiform layer using GABA. A protein coding gene IGLL1 in human. - PRO:DNx + PRO:DNx @@ -562594,7 +563036,7 @@ plexiform layer using GABA. A protein coding gene IL1RL1 in human. - PRO:DNx + PRO:DNx @@ -562619,7 +563061,7 @@ plexiform layer using GABA. A protein coding gene IL2RA in human. - PRO:DNx + PRO:DNx @@ -562644,7 +563086,7 @@ plexiform layer using GABA. A protein coding gene IL2RB in human. - PRO:DNx + PRO:DNx @@ -562669,7 +563111,7 @@ plexiform layer using GABA. A protein coding gene IL3RA in human. - PRO:DNx + PRO:DNx @@ -562694,7 +563136,7 @@ plexiform layer using GABA. A protein coding gene IL5RA in human. - PRO:DNx + PRO:DNx @@ -562719,7 +563161,7 @@ plexiform layer using GABA. A protein coding gene IL7R in human. - PRO:DNx + PRO:DNx @@ -562744,7 +563186,7 @@ plexiform layer using GABA. A protein coding gene CXCR1 in human. - PRO:DNx + PRO:DNx @@ -562769,7 +563211,7 @@ plexiform layer using GABA. A protein coding gene CXCR2 in human. - PRO:DNx + PRO:DNx @@ -562794,7 +563236,7 @@ plexiform layer using GABA. A protein coding gene FOXP3 in human. - PRO:DNx + PRO:DNx @@ -562819,7 +563261,7 @@ plexiform layer using GABA. A protein coding gene ITGA2 in human. - PRO:DNx + PRO:DNx @@ -562844,7 +563286,7 @@ plexiform layer using GABA. A protein coding gene ITGA2B in human. - PRO:DNx + PRO:DNx @@ -562869,7 +563311,7 @@ plexiform layer using GABA. A protein coding gene ITGA4 in human. - PRO:DNx + PRO:DNx @@ -562894,7 +563336,7 @@ plexiform layer using GABA. A protein coding gene ITGAE in human. - PRO:DNx + PRO:DNx @@ -562919,7 +563361,7 @@ plexiform layer using GABA. A protein coding gene ITGAM in human. - PRO:DNx + PRO:DNx @@ -562944,7 +563386,7 @@ plexiform layer using GABA. A protein coding gene ITGAX in human. - PRO:DNx + PRO:DNx @@ -562969,7 +563411,7 @@ plexiform layer using GABA. A protein coding gene ITGB7 in human. - PRO:DNx + PRO:DNx @@ -562994,7 +563436,7 @@ plexiform layer using GABA. A protein coding gene KDR in human. - PRO:DNx + PRO:DNx @@ -563019,7 +563461,7 @@ plexiform layer using GABA. A protein coding gene KIT in human. - PRO:DNx + PRO:DNx @@ -563044,7 +563486,7 @@ plexiform layer using GABA. A protein coding gene KLRB1 in human. - PRO:DNx + PRO:DNx @@ -563069,7 +563511,7 @@ plexiform layer using GABA. A protein coding gene KLRC1 in human. - PRO:DNx + PRO:DNx @@ -563094,7 +563536,7 @@ plexiform layer using GABA. A protein coding gene KLRD1 in human. - PRO:DNx + PRO:DNx @@ -563119,7 +563561,7 @@ plexiform layer using GABA. A protein coding gene KLRG1 in human. - PRO:DNx + PRO:DNx @@ -563144,7 +563586,7 @@ plexiform layer using GABA. A protein coding gene LCN2 in human. - PRO:DNx + PRO:DNx @@ -563169,7 +563611,7 @@ plexiform layer using GABA. A protein coding gene LGALS1 in human. - PRO:DNx + PRO:DNx @@ -563194,7 +563636,7 @@ plexiform layer using GABA. A protein coding gene LHX3 in human. - PRO:DNx + PRO:DNx @@ -563219,7 +563661,7 @@ plexiform layer using GABA. A protein coding gene ARG1 in human. - PRO:DNx + PRO:DNx @@ -563244,7 +563686,7 @@ plexiform layer using GABA. A protein coding gene LTF in human. - PRO:DNx + PRO:DNx @@ -563269,7 +563711,7 @@ plexiform layer using GABA. A protein coding gene LUM in human. - PRO:DNx + PRO:DNx @@ -563294,7 +563736,7 @@ plexiform layer using GABA. A protein coding gene LY75 in human. - PRO:DNx + PRO:DNx @@ -563319,7 +563761,7 @@ plexiform layer using GABA. A protein coding gene NCR1 in human. - PRO:DNx + PRO:DNx @@ -563344,7 +563786,7 @@ plexiform layer using GABA. A protein coding gene NCR2 in human. - PRO:DNx + PRO:DNx @@ -563369,7 +563811,7 @@ plexiform layer using GABA. A protein coding gene MARCO in human. - PRO:DNx + PRO:DNx @@ -563394,7 +563836,7 @@ plexiform layer using GABA. A protein coding gene MEIS2 in human. - PRO:DNx + PRO:DNx @@ -563419,7 +563861,7 @@ plexiform layer using GABA. A protein coding gene MERTK in human. - PRO:DNx + PRO:DNx @@ -563444,7 +563886,7 @@ plexiform layer using GABA. A protein coding gene MME in human. - PRO:DNx + PRO:DNx @@ -563469,7 +563911,7 @@ plexiform layer using GABA. A protein coding gene MPO in human. - PRO:DNx + PRO:DNx @@ -563494,7 +563936,7 @@ plexiform layer using GABA. A protein coding gene MRC1 in human. - PRO:DNx + PRO:DNx @@ -563519,7 +563961,7 @@ plexiform layer using GABA. A protein coding gene MS4A1 in human. - PRO:DNx + PRO:DNx @@ -563544,7 +563986,7 @@ plexiform layer using GABA. A protein coding gene MSR1 in human. - PRO:DNx + PRO:DNx @@ -563569,7 +564011,7 @@ plexiform layer using GABA. A protein coding gene MYB in human. - PRO:DNx + PRO:DNx @@ -563594,7 +564036,7 @@ plexiform layer using GABA. A protein coding gene NCAM1 in human. - PRO:DNx + PRO:DNx @@ -563619,7 +564061,7 @@ plexiform layer using GABA. A protein coding gene NFKB2 in human. - PRO:DNx + PRO:DNx @@ -563644,7 +564086,7 @@ plexiform layer using GABA. A protein coding gene PAX5 in human. - PRO:DNx + PRO:DNx @@ -563669,7 +564111,7 @@ plexiform layer using GABA. A protein coding gene PDCD1 in human. - PRO:DNx + PRO:DNx @@ -563694,7 +564136,7 @@ plexiform layer using GABA. A protein coding gene PDGFRA in human. - PRO:DNx + PRO:DNx @@ -563719,7 +564161,7 @@ plexiform layer using GABA. A protein coding gene PLAUR in human. - PRO:DNx + PRO:DNx @@ -563744,7 +564186,7 @@ plexiform layer using GABA. A protein coding gene PRF1 in human. - PRO:DNx + PRO:DNx @@ -563769,7 +564211,7 @@ plexiform layer using GABA. A protein coding gene PRG2 in human. - PRO:DNx + PRO:DNx @@ -563794,7 +564236,7 @@ plexiform layer using GABA. A protein coding gene PROM1 in human. - PRO:DNx + PRO:DNx @@ -563819,7 +564261,7 @@ plexiform layer using GABA. A protein coding gene SIRPA in human. - PRO:DNx + PRO:DNx @@ -563844,7 +564286,7 @@ plexiform layer using GABA. A protein coding gene PTPRC in human. - PRO:DNx + PRO:DNx @@ -563869,7 +564311,7 @@ plexiform layer using GABA. A protein coding gene PVALB in human. - PRO:DNx + PRO:DNx @@ -563894,7 +564336,7 @@ plexiform layer using GABA. A protein coding gene RAG1 in human. - PRO:DNx + PRO:DNx @@ -563919,7 +564361,7 @@ plexiform layer using GABA. A protein coding gene RAG2 in human. - PRO:DNx + PRO:DNx @@ -563944,7 +564386,7 @@ plexiform layer using GABA. A protein coding gene Cd86 in mouse. - PRO:DNx + PRO:DNx @@ -563969,7 +564411,7 @@ plexiform layer using GABA. A protein coding gene Cd80 in mouse. - PRO:DNx + PRO:DNx @@ -563994,7 +564436,7 @@ plexiform layer using GABA. A protein coding gene Klra4 in mouse. - PRO:DNx + PRO:DNx @@ -564019,7 +564461,7 @@ plexiform layer using GABA. A protein coding gene Klra3 in mouse. - PRO:DNx + PRO:DNx @@ -564044,7 +564486,7 @@ plexiform layer using GABA. A protein coding gene Klra1 in mouse. - PRO:DNx + PRO:DNx @@ -564069,7 +564511,7 @@ plexiform layer using GABA. A protein coding gene Lhx3 in mouse. - PRO:DNx + PRO:DNx @@ -564094,7 +564536,7 @@ plexiform layer using GABA. A protein coding gene Klra8 in mouse. - PRO:DNx + PRO:DNx @@ -564119,7 +564561,7 @@ plexiform layer using GABA. A protein coding gene Ccr7 in mouse. - PRO:DNx + PRO:DNx @@ -564144,7 +564586,7 @@ plexiform layer using GABA. A protein coding gene Prg2 in mouse. - PRO:DNx + PRO:DNx @@ -564169,7 +564611,7 @@ plexiform layer using GABA. A protein coding gene Cxcr5 in mouse. - PRO:DNx + PRO:DNx @@ -564194,7 +564636,7 @@ plexiform layer using GABA. A protein coding gene Cebpe in mouse. - PRO:DNx + PRO:DNx @@ -564219,7 +564661,7 @@ plexiform layer using GABA. A protein coding gene Ccr3 in mouse. - PRO:DNx + PRO:DNx @@ -564244,7 +564686,7 @@ plexiform layer using GABA. A protein coding gene Ccr1 in mouse. - PRO:DNx + PRO:DNx @@ -564269,7 +564711,7 @@ plexiform layer using GABA. A protein coding gene Rorc in mouse. - PRO:DNx + PRO:DNx @@ -564294,7 +564736,7 @@ plexiform layer using GABA. A protein coding gene Pdcd1 in mouse. - PRO:DNx + PRO:DNx @@ -564319,7 +564761,7 @@ plexiform layer using GABA. A protein coding gene Cdh5 in mouse. - PRO:DNx + PRO:DNx @@ -564344,7 +564786,7 @@ plexiform layer using GABA. A protein coding gene Cxcr2 in mouse. - PRO:DNx + PRO:DNx @@ -564369,7 +564811,7 @@ plexiform layer using GABA. A protein coding gene Ccr2 in mouse. - PRO:DNx + PRO:DNx @@ -564394,7 +564836,7 @@ plexiform layer using GABA. A protein coding gene Tmed1 in mouse. - PRO:DNx + PRO:DNx @@ -564419,7 +564861,7 @@ plexiform layer using GABA. A protein coding gene Enpep in mouse. - PRO:DNx + PRO:DNx @@ -564444,7 +564886,7 @@ plexiform layer using GABA. A protein coding gene Ly75 in mouse. - PRO:DNx + PRO:DNx @@ -564469,7 +564911,7 @@ plexiform layer using GABA. A protein coding gene Cd93 in mouse. - PRO:DNx + PRO:DNx @@ -564494,7 +564936,7 @@ plexiform layer using GABA. A protein coding gene Ly76 in mouse. - PRO:DNx + PRO:DNx @@ -564519,7 +564961,7 @@ plexiform layer using GABA. A protein coding gene Adgre1 in mouse. - PRO:DNx + PRO:DNx @@ -564544,7 +564986,7 @@ plexiform layer using GABA. A protein coding gene Ccr5 in mouse. - PRO:DNx + PRO:DNx @@ -564569,7 +565011,7 @@ plexiform layer using GABA. A protein coding gene Bcl6 in mouse. - PRO:DNx + PRO:DNx @@ -564594,7 +565036,7 @@ plexiform layer using GABA. A protein coding gene Fpr1 in mouse. - PRO:DNx + PRO:DNx @@ -564619,7 +565061,7 @@ plexiform layer using GABA. A protein coding gene Cd38 in mouse. - PRO:DNx + PRO:DNx @@ -564644,7 +565086,7 @@ plexiform layer using GABA. A protein coding gene Ly6a in mouse. - PRO:DNx + PRO:DNx @@ -564669,7 +565111,7 @@ plexiform layer using GABA. A protein coding gene Klrb1c in mouse. - PRO:DNx + PRO:DNx @@ -564694,7 +565136,7 @@ plexiform layer using GABA. A protein coding gene Epx in mouse. - PRO:DNx + PRO:DNx @@ -564719,7 +565161,7 @@ plexiform layer using GABA. A protein coding gene Cd1d1 in mouse. - PRO:DNx + PRO:DNx @@ -564744,7 +565186,7 @@ plexiform layer using GABA. A protein coding gene Ctsk in mouse. - PRO:DNx + PRO:DNx @@ -564769,7 +565211,7 @@ plexiform layer using GABA. A protein coding gene Ccr4 in mouse. - PRO:DNx + PRO:DNx @@ -564794,7 +565236,7 @@ plexiform layer using GABA. A protein coding gene Cd36 in mouse. - PRO:DNx + PRO:DNx @@ -564819,7 +565261,7 @@ plexiform layer using GABA. A protein coding gene Sirpa in mouse. - PRO:DNx + PRO:DNx @@ -564844,7 +565286,7 @@ plexiform layer using GABA. A protein coding gene Meis2 in mouse. - PRO:DNx + PRO:DNx @@ -564869,7 +565311,7 @@ plexiform layer using GABA. A protein coding gene Cd244 in mouse. - PRO:DNx + PRO:DNx @@ -564894,7 +565336,7 @@ plexiform layer using GABA. A protein coding gene Lum in mouse. - PRO:DNx + PRO:DNx @@ -564919,7 +565361,7 @@ plexiform layer using GABA. A protein coding gene Ly6g in mouse. - PRO:DNx + PRO:DNx @@ -564944,7 +565386,7 @@ plexiform layer using GABA. A protein coding gene Trpc3 in mouse. - PRO:DNx + PRO:DNx @@ -564969,7 +565411,7 @@ plexiform layer using GABA. A protein coding gene Cxcr4 in mouse. - PRO:DNx + PRO:DNx @@ -564994,7 +565436,7 @@ plexiform layer using GABA. A protein coding gene Nfkb2 in mouse. - PRO:DNx + PRO:DNx @@ -565019,7 +565461,7 @@ plexiform layer using GABA. A protein coding gene Prom1 in mouse. - PRO:DNx + PRO:DNx @@ -565044,7 +565486,7 @@ plexiform layer using GABA. A protein coding gene Klrd1 in mouse. - PRO:DNx + PRO:DNx @@ -565069,7 +565511,7 @@ plexiform layer using GABA. A protein coding gene Eomes in mouse. - PRO:DNx + PRO:DNx @@ -565094,7 +565536,7 @@ plexiform layer using GABA. A protein coding gene Cxcr3 in mouse. - PRO:DNx + PRO:DNx @@ -565119,7 +565561,7 @@ plexiform layer using GABA. A protein coding gene Itgae in mouse. - PRO:DNx + PRO:DNx @@ -565144,7 +565586,7 @@ plexiform layer using GABA. A protein coding gene Sncg in mouse. - PRO:DNx + PRO:DNx @@ -565169,7 +565611,7 @@ plexiform layer using GABA. A protein coding gene Marco in mouse. - PRO:DNx + PRO:DNx @@ -565194,7 +565636,7 @@ plexiform layer using GABA. A protein coding gene Tnfrsf11a in mouse. - PRO:DNx + PRO:DNx @@ -565219,7 +565661,7 @@ plexiform layer using GABA. A protein coding gene Cd83 in mouse. - PRO:DNx + PRO:DNx @@ -565244,7 +565686,7 @@ plexiform layer using GABA. A protein coding gene Ptgdr2 in mouse. - PRO:DNx + PRO:DNx @@ -565269,7 +565711,7 @@ plexiform layer using GABA. A protein coding gene Gp1ba in mouse. - PRO:DNx + PRO:DNx @@ -565294,7 +565736,7 @@ plexiform layer using GABA. A protein coding gene Ccr6 in mouse. - PRO:DNx + PRO:DNx @@ -565319,7 +565761,7 @@ plexiform layer using GABA. A protein coding gene Cx3cr1 in mouse. - PRO:DNx + PRO:DNx @@ -565344,7 +565786,7 @@ plexiform layer using GABA. A protein coding gene Ncr1 in mouse. - PRO:DNx + PRO:DNx @@ -565369,7 +565811,7 @@ plexiform layer using GABA. A protein coding gene Cd84 in mouse. - PRO:DNx + PRO:DNx @@ -565394,7 +565836,7 @@ plexiform layer using GABA. A protein coding gene Csf1r in mouse. - PRO:DNx + PRO:DNx @@ -565419,7 +565861,7 @@ plexiform layer using GABA. A protein coding gene Sdc1 in mouse. - PRO:DNx + PRO:DNx @@ -565444,7 +565886,7 @@ plexiform layer using GABA. A protein coding gene Slamf1 in mouse. - PRO:DNx + PRO:DNx @@ -565469,7 +565911,7 @@ plexiform layer using GABA. A protein coding gene Il17rb in mouse. - PRO:DNx + PRO:DNx @@ -565494,7 +565936,7 @@ plexiform layer using GABA. A protein coding gene Klrg1 in mouse. - PRO:DNx + PRO:DNx @@ -565519,7 +565961,7 @@ plexiform layer using GABA. A protein coding gene Icos in mouse. - PRO:DNx + PRO:DNx @@ -565544,7 +565986,7 @@ plexiform layer using GABA. A protein coding gene Clec4n in mouse. - PRO:DNx + PRO:DNx @@ -565569,7 +566011,7 @@ plexiform layer using GABA. A protein coding gene Clec7a in mouse. - PRO:DNx + PRO:DNx @@ -565594,7 +566036,7 @@ plexiform layer using GABA. A protein coding gene Tbx21 in mouse. - PRO:DNx + PRO:DNx @@ -565619,7 +566061,7 @@ plexiform layer using GABA. A protein coding gene Foxp3 in mouse. - PRO:DNx + PRO:DNx @@ -565644,7 +566086,7 @@ plexiform layer using GABA. A protein coding gene Cd209b in mouse. - PRO:DNx + PRO:DNx @@ -565669,7 +566111,7 @@ plexiform layer using GABA. A protein coding gene Bst2 in mouse. - PRO:DNx + PRO:DNx @@ -565694,7 +566136,7 @@ plexiform layer using GABA. A protein coding gene Cd200r3 in mouse. - PRO:DNx + PRO:DNx @@ -565719,7 +566161,7 @@ plexiform layer using GABA. A protein coding gene Lamp5 in mouse. - PRO:DNx + PRO:DNx @@ -565744,7 +566186,7 @@ plexiform layer using GABA. A protein coding gene Irx6 in mouse. - PRO:DNx + PRO:DNx @@ -565769,7 +566211,7 @@ plexiform layer using GABA. A protein coding gene Ntng1 in mouse. - PRO:DNx + PRO:DNx @@ -565794,7 +566236,7 @@ plexiform layer using GABA. A protein coding gene Cd163 in mouse. - PRO:DNx + PRO:DNx @@ -565819,7 +566261,7 @@ plexiform layer using GABA. A protein coding gene Enpp3 in mouse. - PRO:DNx + PRO:DNx @@ -565844,7 +566286,7 @@ plexiform layer using GABA. A protein coding gene Cd207 in mouse. - PRO:DNx + PRO:DNx @@ -565869,7 +566311,7 @@ plexiform layer using GABA. A protein coding gene Neto1 in mouse. - PRO:DNx + PRO:DNx @@ -565894,7 +566336,7 @@ plexiform layer using GABA. A protein coding gene A4galt in mouse. - PRO:DNx + PRO:DNx @@ -565919,7 +566361,7 @@ plexiform layer using GABA. A protein coding gene Ly6c2 in mouse. - PRO:DNx + PRO:DNx @@ -565944,7 +566386,7 @@ plexiform layer using GABA. A protein coding gene Anpep in mouse. - PRO:DNx + PRO:DNx @@ -565969,7 +566411,7 @@ plexiform layer using GABA. A protein coding gene Acp5 in mouse. - PRO:DNx + PRO:DNx @@ -565994,7 +566436,7 @@ plexiform layer using GABA. A protein coding gene Arg1 in mouse. - PRO:DNx + PRO:DNx @@ -566019,7 +566461,7 @@ plexiform layer using GABA. A protein coding gene Cck in mouse. - PRO:DNx + PRO:DNx @@ -566044,7 +566486,7 @@ plexiform layer using GABA. A protein coding gene Cd14 in mouse. - PRO:DNx + PRO:DNx @@ -566069,7 +566511,7 @@ plexiform layer using GABA. A protein coding gene Cd19 in mouse. - PRO:DNx + PRO:DNx @@ -566094,7 +566536,7 @@ plexiform layer using GABA. A protein coding gene Cd2 in mouse. - PRO:DNx + PRO:DNx @@ -566119,7 +566561,7 @@ plexiform layer using GABA. A protein coding gene Ms4a1 in mouse. - PRO:DNx + PRO:DNx @@ -566144,7 +566586,7 @@ plexiform layer using GABA. A protein coding gene Cd22 in mouse. - PRO:DNx + PRO:DNx @@ -566169,7 +566611,7 @@ plexiform layer using GABA. A protein coding gene Cd24a in mouse. - PRO:DNx + PRO:DNx @@ -566194,7 +566636,7 @@ plexiform layer using GABA. A protein coding gene Cd27 in mouse. - PRO:DNx + PRO:DNx @@ -566219,7 +566661,7 @@ plexiform layer using GABA. A protein coding gene Cd28 in mouse. - PRO:DNx + PRO:DNx @@ -566244,7 +566686,7 @@ plexiform layer using GABA. A protein coding gene Cd34 in mouse. - PRO:DNx + PRO:DNx @@ -566269,7 +566711,7 @@ plexiform layer using GABA. A protein coding gene Cd3e in mouse. - PRO:DNx + PRO:DNx @@ -566294,7 +566736,7 @@ plexiform layer using GABA. A protein coding gene Cd4 in mouse. - PRO:DNx + PRO:DNx @@ -566319,7 +566761,7 @@ plexiform layer using GABA. A protein coding gene Cd40lg in mouse. - PRO:DNx + PRO:DNx @@ -566344,7 +566786,7 @@ plexiform layer using GABA. A protein coding gene Cd44 in mouse. - PRO:DNx + PRO:DNx @@ -566369,7 +566811,7 @@ plexiform layer using GABA. A protein coding gene Cd48 in mouse. - PRO:DNx + PRO:DNx @@ -566394,7 +566836,7 @@ plexiform layer using GABA. A protein coding gene Cd5 in mouse. - PRO:DNx + PRO:DNx @@ -566419,7 +566861,7 @@ plexiform layer using GABA. A protein coding gene Cd68 in mouse. - PRO:DNx + PRO:DNx @@ -566444,7 +566886,7 @@ plexiform layer using GABA. A protein coding gene Cd69 in mouse. - PRO:DNx + PRO:DNx @@ -566469,7 +566911,7 @@ plexiform layer using GABA. A protein coding gene Cd7 in mouse. - PRO:DNx + PRO:DNx @@ -566494,7 +566936,7 @@ plexiform layer using GABA. A protein coding gene Cd8a in mouse. - PRO:DNx + PRO:DNx @@ -566519,7 +566961,7 @@ plexiform layer using GABA. A protein coding gene Cd8b1 in mouse. - PRO:DNx + PRO:DNx @@ -566544,7 +566986,7 @@ plexiform layer using GABA. A protein coding gene Cd9 in mouse. - PRO:DNx + PRO:DNx @@ -566569,7 +567011,7 @@ plexiform layer using GABA. A protein coding gene Cdh1 in mouse. - PRO:DNx + PRO:DNx @@ -566594,7 +567036,7 @@ plexiform layer using GABA. A protein coding gene Col1a1 in mouse. - PRO:DNx + PRO:DNx @@ -566619,7 +567061,7 @@ plexiform layer using GABA. A protein coding gene Cr2 in mouse. - PRO:DNx + PRO:DNx @@ -566644,7 +567086,7 @@ plexiform layer using GABA. A protein coding gene Ctla4 in mouse. - PRO:DNx + PRO:DNx @@ -566669,7 +567111,7 @@ plexiform layer using GABA. A protein coding gene Egr2 in mouse. - PRO:DNx + PRO:DNx @@ -566694,7 +567136,7 @@ plexiform layer using GABA. A protein coding gene Eng in mouse. - PRO:DNx + PRO:DNx @@ -566719,7 +567161,7 @@ plexiform layer using GABA. A protein coding gene Fcer1a in mouse. - PRO:DNx + PRO:DNx @@ -566744,7 +567186,7 @@ plexiform layer using GABA. A protein coding gene Fcer2a in mouse. - PRO:DNx + PRO:DNx @@ -566769,7 +567211,7 @@ plexiform layer using GABA. A protein coding gene Fcgr1 in mouse. - PRO:DNx + PRO:DNx @@ -566794,7 +567236,7 @@ plexiform layer using GABA. A protein coding gene Fcgr2 in mouse. - PRO:DNx + PRO:DNx @@ -566819,7 +567261,7 @@ plexiform layer using GABA. A protein coding gene Fcgr3 in mouse. - PRO:DNx + PRO:DNx @@ -566844,7 +567286,7 @@ plexiform layer using GABA. A protein coding gene Flt3 in mouse. - PRO:DNx + PRO:DNx @@ -566869,7 +567311,7 @@ plexiform layer using GABA. A protein coding gene Fos in mouse. - PRO:DNx + PRO:DNx @@ -566894,7 +567336,7 @@ plexiform layer using GABA. A protein coding gene Fut4 in mouse. - PRO:DNx + PRO:DNx @@ -566919,7 +567361,7 @@ plexiform layer using GABA. A protein coding gene Gata1 in mouse. - PRO:DNx + PRO:DNx @@ -566944,7 +567386,7 @@ plexiform layer using GABA. A protein coding gene Gata2 in mouse. - PRO:DNx + PRO:DNx @@ -566969,7 +567411,7 @@ plexiform layer using GABA. A protein coding gene Gata3 in mouse. - PRO:DNx + PRO:DNx @@ -566994,7 +567436,7 @@ plexiform layer using GABA. A protein coding gene Gfap in mouse. - PRO:DNx + PRO:DNx @@ -567019,7 +567461,7 @@ plexiform layer using GABA. A protein coding gene H2-Ea in mouse. - PRO:DNx + PRO:DNx @@ -567044,7 +567486,7 @@ plexiform layer using GABA. A protein coding gene Hba-x in mouse. - PRO:DNx + PRO:DNx @@ -567069,7 +567511,7 @@ plexiform layer using GABA. A protein coding gene Hbb-b1 in mouse. - PRO:DNx + PRO:DNx @@ -567094,7 +567536,7 @@ plexiform layer using GABA. A protein coding gene Il2ra in mouse. - PRO:DNx + PRO:DNx @@ -567119,7 +567561,7 @@ plexiform layer using GABA. A protein coding gene Il2rb in mouse. - PRO:DNx + PRO:DNx @@ -567144,7 +567586,7 @@ plexiform layer using GABA. A protein coding gene Il3ra in mouse. - PRO:DNx + PRO:DNx @@ -567169,7 +567611,7 @@ plexiform layer using GABA. A protein coding gene Il5ra in mouse. - PRO:DNx + PRO:DNx @@ -567194,7 +567636,7 @@ plexiform layer using GABA. A protein coding gene Il7r in mouse. - PRO:DNx + PRO:DNx @@ -567219,7 +567661,7 @@ plexiform layer using GABA. A protein coding gene Itga2 in mouse. - PRO:DNx + PRO:DNx @@ -567244,7 +567686,7 @@ plexiform layer using GABA. A protein coding gene Itga2b in mouse. - PRO:DNx + PRO:DNx @@ -567269,7 +567711,7 @@ plexiform layer using GABA. A protein coding gene Itga4 in mouse. - PRO:DNx + PRO:DNx @@ -567294,7 +567736,7 @@ plexiform layer using GABA. A protein coding gene Itgam in mouse. - PRO:DNx + PRO:DNx @@ -567319,7 +567761,7 @@ plexiform layer using GABA. A protein coding gene Itgax in mouse. - PRO:DNx + PRO:DNx @@ -567344,7 +567786,7 @@ plexiform layer using GABA. A protein coding gene Itgb7 in mouse. - PRO:DNx + PRO:DNx @@ -567369,7 +567811,7 @@ plexiform layer using GABA. A protein coding gene Kit in mouse. - PRO:DNx + PRO:DNx @@ -567394,7 +567836,7 @@ plexiform layer using GABA. A protein coding gene Kdr in mouse. - PRO:DNx + PRO:DNx @@ -567419,7 +567861,7 @@ plexiform layer using GABA. A protein coding gene Lcn2 in mouse. - PRO:DNx + PRO:DNx @@ -567444,7 +567886,7 @@ plexiform layer using GABA. A protein coding gene Lgals1 in mouse. - PRO:DNx + PRO:DNx @@ -567469,7 +567911,7 @@ plexiform layer using GABA. A protein coding gene Ltf in mouse. - PRO:DNx + PRO:DNx @@ -567494,7 +567936,7 @@ plexiform layer using GABA. A protein coding gene Mertk in mouse. - PRO:DNx + PRO:DNx @@ -567519,7 +567961,7 @@ plexiform layer using GABA. A protein coding gene Mme in mouse. - PRO:DNx + PRO:DNx @@ -567544,7 +567986,7 @@ plexiform layer using GABA. A protein coding gene Mpo in mouse. - PRO:DNx + PRO:DNx @@ -567569,7 +568011,7 @@ plexiform layer using GABA. A protein coding gene Mrc1 in mouse. - PRO:DNx + PRO:DNx @@ -567594,7 +568036,7 @@ plexiform layer using GABA. A protein coding gene Myb in mouse. - PRO:DNx + PRO:DNx @@ -567619,7 +568061,7 @@ plexiform layer using GABA. A protein coding gene Ncam1 in mouse. - PRO:DNx + PRO:DNx @@ -567644,7 +568086,7 @@ plexiform layer using GABA. A protein coding gene Pax5 in mouse. - PRO:DNx + PRO:DNx @@ -567669,7 +568111,7 @@ plexiform layer using GABA. A protein coding gene Pdgfra in mouse. - PRO:DNx + PRO:DNx @@ -567694,7 +568136,7 @@ plexiform layer using GABA. A protein coding gene Prf1 in mouse. - PRO:DNx + PRO:DNx @@ -567719,7 +568161,7 @@ plexiform layer using GABA. A protein coding gene Plaur in mouse. - PRO:DNx + PRO:DNx @@ -567744,7 +568186,7 @@ plexiform layer using GABA. A protein coding gene Pvalb in mouse. - PRO:DNx + PRO:DNx @@ -567769,7 +568211,7 @@ plexiform layer using GABA. A protein coding gene Rag1 in mouse. - PRO:DNx + PRO:DNx @@ -567794,7 +568236,7 @@ plexiform layer using GABA. A protein coding gene Rag2 in mouse. - PRO:DNx + PRO:DNx @@ -567819,7 +568261,7 @@ plexiform layer using GABA. A protein coding gene Msr1 in mouse. - PRO:DNx + PRO:DNx @@ -567844,7 +568286,7 @@ plexiform layer using GABA. A protein coding gene Sell in mouse. - PRO:DNx + PRO:DNx @@ -567869,7 +568311,7 @@ plexiform layer using GABA. A protein coding gene Spi1 in mouse. - PRO:DNx + PRO:DNx @@ -567894,7 +568336,7 @@ plexiform layer using GABA. A protein coding gene Sst in mouse. - PRO:DNx + PRO:DNx @@ -567919,7 +568361,7 @@ plexiform layer using GABA. A protein coding gene Spn in mouse. - PRO:DNx + PRO:DNx @@ -567944,7 +568386,7 @@ plexiform layer using GABA. A protein coding gene Il1rl1 in mouse. - PRO:DNx + PRO:DNx @@ -567969,7 +568411,7 @@ plexiform layer using GABA. A protein coding gene Tal1 in mouse. - PRO:DNx + PRO:DNx @@ -567994,7 +568436,7 @@ plexiform layer using GABA. A protein coding gene Dntt in mouse. - PRO:DNx + PRO:DNx @@ -568019,7 +568461,7 @@ plexiform layer using GABA. A protein coding gene Thbd in mouse. - PRO:DNx + PRO:DNx @@ -568044,7 +568486,7 @@ plexiform layer using GABA. A protein coding gene Thy1 in mouse. - PRO:DNx + PRO:DNx @@ -568069,7 +568511,7 @@ plexiform layer using GABA. A protein coding gene Tfrc in mouse. - PRO:DNx + PRO:DNx @@ -568094,7 +568536,7 @@ plexiform layer using GABA. A protein coding gene Vip in mouse. - PRO:DNx + PRO:DNx @@ -568119,7 +568561,7 @@ plexiform layer using GABA. A protein coding gene Cd33 in mouse. - PRO:DNx + PRO:DNx @@ -568144,7 +568586,7 @@ plexiform layer using GABA. A protein coding gene Cebpa in mouse. - PRO:DNx + PRO:DNx @@ -568169,7 +568611,7 @@ plexiform layer using GABA. A protein coding gene Siglec1 in mouse. - PRO:DNx + PRO:DNx @@ -568194,7 +568636,7 @@ plexiform layer using GABA. A protein coding gene Chrna7 in mouse. - PRO:DNx + PRO:DNx @@ -568219,7 +568661,7 @@ plexiform layer using GABA. A protein coding gene Runx1 in mouse. - PRO:DNx + PRO:DNx @@ -569056,6 +569498,12 @@ plexiform layer using GABA. + + + + + + @@ -569165,6 +569613,178 @@ plexiform layer using GABA. + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + true MF(X)-directly_regulates->MF(Y)-enabled_by->GP(Z) => MF(Y)-has_input->GP(Y) e.g. if 'protein kinase activity'(X) directly_regulates 'protein binding activity (Y)and this is enabled by GP(Z) then X has_input Z diff --git a/imports/chebi_import.owl b/imports/chebi_import.owl index 1b996988d..bf1e907b8 100644 --- a/imports/chebi_import.owl +++ b/imports/chebi_import.owl @@ -12,8 +12,8 @@ xmlns:chebi2="http://purl.obolibrary.org/obo/chebi#1" xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"> - - 2021-02-01 + + 2021-06-28 diff --git a/imports/clo_import.owl b/imports/clo_import.owl index 39c720d34..68c6cb643 100644 --- a/imports/clo_import.owl +++ b/imports/clo_import.owl @@ -4,8 +4,6 @@ xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:go="http://purl.obolibrary.org/obo/go#" xmlns:efo="http://www.ebi.ac.uk/efo/" - xmlns:go1="http://purl.oboInOwllibrary.org/oboInOwl/go#" - xmlns:go2="http://purl.oboInOwlInOwllibrary.org/oboInOwlInOwl/go#" xmlns:obo="http://purl.obolibrary.org/obo/" xmlns:owl="http://www.w3.org/2002/07/owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" @@ -15,22 +13,15 @@ xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:pato="http://purl.obolibrary.org/obo/pato#" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" - xmlns:chebi="http://purl.oboInOwllibrary.org/oboInOwl/chebi#3" - xmlns:pato8="http://purl.oboInOwllibrary.org/oboInOwl/pato#" - xmlns:chebi4="http://purl.oboInOwlInOwllibrary.org/oboInOwlInOwl/chebi#3" - xmlns:uberon="http://purl.oboInOwllibrary.org/oboInOwl/uberon#" - xmlns:ubprop="http://purl.oboInOwlInOwllibrary.org/oboInOwlInOwl/ubprop#" + xmlns:uberon="http://purl.obolibrary.org/obo/uberon#" + xmlns:ubprop="http://purl.obolibrary.org/obo/ubprop#" xmlns:subsets="http://purl.obolibrary.org/obo/ro/subsets#" - xmlns:uberon3="http://purl.obolibrary.org/obo/uberon#" - xmlns:ubprop5="http://purl.oboInOwllibrary.org/oboInOwl/ubprop#" - xmlns:ubprop7="http://purl.obolibrary.org/obo/ubprop#" xmlns:cellline="http://www.ebi.ac.uk/cellline/" xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#" - xmlns:subsets6="http://purl.oboInOwllibrary.org/oboInOwl/ro/subsets#" xmlns:ncbitaxon="http://purl.obolibrary.org/obo/ncbitaxon#"> - - 2021-02-01 + + 2021-06-28 @@ -46,358 +37,6 @@ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - @@ -623,7 +262,30 @@ We also have the outstanding issue of how to aim different definitions to differ - + + RO:0002175 + RO:0002175 + applicable for taxon + applicable for taxon + 适用于分类单元 + uberon + uberon + present_in_taxon + present_in_taxon + 存在_于_分类 + true + true + present_in_taxon + present_in_taxon + 存在_于_分类 + present_in_taxon + present_in_taxon + 存在_于_分类 + 存在_于_分类 + S present_in_taxon T if some instance of T has some S. This does not means that all instances of T have an S - it may only be certain life stages or sexes that have S + S present_in_taxon T if some instance of T has some S. This does not means that all instances of T have an S - it may only be certain life stages or sexes that have S + S存在_于_分类 T如果T的某个实例有一些S，这并不意味着T的所有实例都有S - 它可能只是某些生命阶段或者性别具有S + @@ -759,6 +421,12 @@ We also have the outstanding issue of how to aim different definitions to differ + + + + + + @@ -1090,6 +758,12 @@ We also have the outstanding issue of how to aim different definitions to differ + + + + + + @@ -1317,9 +991,19 @@ We also have the outstanding issue of how to aim different definitions to differ + + + + + + - + + depicted_by + depicted_by + 由_描述 + @@ -3313,6 +2997,28 @@ Some currently missing phenomena that should be considered "about" are + + + + + + + + + + + + + + + + An immortal skin-derived cell line cell that derives from cat. + Yongqun He + immortal cat cell line cell + + + + @@ -3494,6 +3200,44 @@ The definition provided here establishes the 'scale' of cell populatio + + + + + + + + + + + + + + + + + + + + + + + + + + + An immortal cell line cell that derives from cat. + An immortal cell line cell that derives from cat. + 源自猫的永生细胞系细胞。 + Yue Liu, Yongqun He + Yue Liu, Yongqun He + + immortal cat cell line cell + 永生的猫细胞系细胞 + + + + @@ -21713,6 +21457,22 @@ IAO澄清这些或改变定义不使用它们的要求 + + + + + Laurasiatheria + Laurasiatheria + 劳亚兽总目 + + + Laurasiatheria + Laurasiatheria + 劳亚兽总目 + + + + @@ -22013,6 +21773,37 @@ IAO澄清这些或改变定义不使用它们的要求 + + + + + + + Carnivora + Carnivora + 食肉目 + "carnivores" EXACT genbank_common_name [] + "carnivores" EXACT genbank_common_name [] + "carnivores" RELATED blast_name [] + "carnivores" RELATED blast_name [] + carnivores + carnivores + “食肉动物(carnivores)” EXACT genbank_common_name [] + “食肉动物(carnivores)” RELATED blast_name [] + 食肉动物(carnivores) + + + Carnivora + Carnivora + 食肉目 + GC_ID:1 + GC_ID:1 + URI: http://www.ebi.ac.uk/cellline#Carnivora + URI: http://www.ebi.ac.uk/cellline#Carnivora + + + + @@ -22029,6 +21820,22 @@ IAO澄清这些或改变定义不使用它们的要求 + + + + + Feliformia + Feliformia + 猫型亚目 + + + Feliformia + Feliformia + 猫型亚目 + + + + @@ -22341,6 +22148,51 @@ IAO澄清这些或改变定义不使用它们的要求 + + + + + + Felis catus + Felis catus + 家猫 + "Felis domesticus" RELATED synonym [] + "Felis domesticus" RELATED synonym [] + "Felis silvestris catus" RELATED synonym [] + "Felis silvestris catus" RELATED synonym [] + "cat" EXACT common_name [] + "cat" EXACT common_name [] + "cats" EXACT common_name [] + "cats" EXACT common_name [] + "domestic cat" EXACT genbank_common_name [] + "domestic cat" EXACT genbank_common_name [] + cat + cat + cats + cats + domestic cat + domestic cat + “家猫(Felis domesticus)” RELATED synonym [] + “家猫(domestic cat)” EXACT genbank_common_name [] + “猫(Felis silvestris catus)” RELATED synonym [] + “猫(cat)” EXACT common_name [] + “猫(cats)” EXACT common_name [] + 家猫(domestic cat) + 猫(cat) + 猫(cats) + + + Felis catus + Felis catus + 家猫 + GC_ID:1 + GC_ID:1 + URI: http://www.ebi.ac.uk/cellline#Felis_catus + URI: http://www.ebi.ac.uk/cellline#Felis_catus + + + + @@ -26783,7 +26635,7 @@ A cultured cell population maintained in vitro: "Rat cortical neurons from A major division of the nervous system that contains nerves which connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands. - + PNS pars peripherica systema nervosum periphericum @@ -27231,8 +27083,8 @@ A cultured cell population maintained in vitro: "Rat cortical neurons from - - + + head (volume) head (volume) 头（体积） @@ -31488,9 +31340,9 @@ A cultured cell population maintained in vitro: "Rat cortical neurons from - - - + + + thorax thorax 胸部 @@ -33662,7 +33514,7 @@ A cultured cell population maintained in vitro: "Rat cortical neurons from - + muscle group muscle group muscles set @@ -35699,7 +35551,7 @@ A cultured cell population maintained in vitro: "Rat cortical neurons from - + skeleton system skeleton system 骨架系统 @@ -35983,7 +35835,7 @@ A cultured cell population maintained in vitro: "Rat cortical neurons from - + upper respiratory tract @@ -36311,7 +36163,7 @@ A cultured cell population maintained in vitro: "Rat cortical neurons from UBERON:0001744 - + lymphatic tissue lymphatic tissue lymphocytic tissue @@ -36363,7 +36215,7 @@ A cultured cell population maintained in vitro: "Rat cortical neurons from - + tunica vasculosa of eyeball tunica vasculosa of eyeball uvea @@ -36650,7 +36502,7 @@ A cultured cell population maintained in vitro: "Rat cortical neurons from - + anterior eye segment anterior eye segment anterior segment eye @@ -37097,8 +36949,8 @@ A cultured cell population maintained in vitro: "Rat cortical neurons from - - + + DiE DiE between brain @@ -37839,8 +37691,8 @@ A cultured cell population maintained in vitro: "Rat cortical neurons from - - + + cerebellum @@ -38570,8 +38422,8 @@ A cultured cell population maintained in vitro: "Rat cortical neurons from - - + + thoracolumbar region thoracolumbar region torso @@ -38604,7 +38456,7 @@ A cultured cell population maintained in vitro: "Rat cortical neurons from - + photosensory system photosensory system visual organ system @@ -39791,7 +39643,7 @@ A cultured cell population maintained in vitro: "Rat cortical neurons from - + @@ -41007,7 +40859,7 @@ A cultured cell population maintained in vitro: "Rat cortical neurons from UBERON:0002385 UBERON:0002385 - + muscular tissue muscular tissue portion of muscle tissue @@ -42341,7 +42193,7 @@ A cultured cell population maintained in vitro: "Rat cortical neurons from Gonochoristic organism that can produce female gametes. - + female human body female @@ -47022,7 +46874,7 @@ A cultured cell population maintained in vitro: "Rat cortical neurons from - + non neural ectoderm non neural ectoderm 非神经外胚层 @@ -48304,7 +48156,7 @@ A cultured cell population maintained in vitro: "Rat cortical neurons from - + dorsal tube dorsal tube heart @@ -52790,6 +52642,12 @@ pulmonary arterial and venous trees. Examples: There is only one heart. + + + + + @@ -52890,26 +52748,26 @@ pulmonary arterial and venous trees. Examples: There is only one heart. CALOHA:TS-0579 - Lymph nodes that are associated with the lymphatic system have evolved in mammals.[well established][VHOG] EV:0100050 + Lymph nodes that are associated with the lymphatic system have evolved in mammals.[well established][VHOG] UBERON:0000029 UMLS:C0024204 MA:0000139 - 淋巴结 GAID:947 ZFA_RETIRED:0005318 + 淋巴结 UMLS:C0024204 - + ZFA_RETIRED:0005318 OpenCyc:Mx4rwLPqLpwpEbGdrcN5Y29ycA 结节淋巴瘤 EV:0100050 - galen:Lymphnode - Any of the rounded masses of lymphoid tissue that are surrounded by a capsule of connective tissue, are distributed along the lymphatic vessels, and contain numerous lymphocytes which filter the flow of lymph. + galen:Lymphnode lymph gland + Any of the rounded masses of lymphoid tissue that are surrounded by a capsule of connective tissue, are distributed along the lymphatic vessels, and contain numerous lymphocytes which filter the flow of lymph. EFO:0000872 lymph node BTO:0000784 @@ -52918,14 +52776,14 @@ pulmonary arterial and venous trees. Examples: There is only one heart. BTO:0000784 MAT:0000442 - FMA:5034 uberon + FMA:5034 VHOG:0001273 lymph node nodus lymphaticus + EMAPA:35523 nodus lymphaticus VHOG:0001273 - EMAPA:35523 uberon TAO_RETIRED:0005318 OpenCyc:Mx4rwLPqLpwpEbGdrcN5Y29ycA @@ -52934,9 +52792,9 @@ pulmonary arterial and venous trees. Examples: There is only one heart. MA:0000139 - EMAPA:35523 - + EMAPA:35523 + 淋巴腺 EFO:0000872 @@ -52953,8 +52811,8 @@ pulmonary arterial and venous trees. Examples: There is only one heart. CALOHA:TS-0579 - TAO_RETIRED:0005318 与淋巴系统有关的淋巴结已经在哺乳动物中进化。[well established][VHOG] + TAO_RETIRED:0005318 UBERON:0000029 galen:Lymphnode @@ -52966,18 +52824,18 @@ pulmonary arterial and venous trees. Examples: There is only one heart.中胚层套膜 The middle germ layer of the embryo, between the endoderm and ectoderm. The middle germ layer of the embryo, between the endoderm and ectoderm. - entire mesoderm + 整个中胚层 中胚层 mesodermal mantle - embryonic mesoderm 胚胎的中间胚层，在内胚层和外胚层之间。 - + embryonic mesoderm 胚胎中胚层 + embryonic mesoderm mesoderm @@ -52990,10 +52848,10 @@ pulmonary arterial and venous trees. Examples: There is only one heart.由呼吸相关结构组成的功能系统。 apparatus respiratorius - - Functional system which consists of structures involved in respiration. - + + Functional system which consists of structures involved in respiration. + systema respiratorium apparatus respiratorius @@ -53014,8 +52872,8 @@ pulmonary arterial and venous trees. Examples: There is only one heart.系统呼吸器 呼吸系统(respiratory system) Atmungssystem - respiratory system systema respiratorium + respiratory system @@ -53038,8 +52896,8 @@ pulmonary arterial and venous trees. Examples: There is only one heart.central nervous system MA:0000167 CALOHA:TS-0150 - CNS + CNS FBbt:00005094 XAO:0000215 The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord. @@ -53052,8 +52910,8 @@ pulmonary arterial and venous trees. Examples: There is only one heart.The brain and spinal cord. Kimmel et al, 1995.[TAO] neuraxis 神经轴 - EHDAA:828 FMA:55675 + EHDAA:828 BAMS:CNS 中枢神经系统(CNS)是神经系统的一部分，其包括视网膜的脑、脊髓和神经细胞层 (CUMBO)。 neuraxis @@ -53064,15 +52922,15 @@ pulmonary arterial and venous trees. Examples: There is only one heart.neuraxis EFO:0000908 The brain and spinal cord. Kimmel et al, 1995.[TAO] - uberon MESH:D002490 + uberon EHDAA2:0000225 BTO:0000227 EMAPA:16754 The central nervous system (CNS) is the part of the nervous system which includes the brain, spinal cord, and nerve cell layer of the retina (CUMBO). - FBbt:00005094 (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...) (reference 1); The neural tube is destined to differentiate into the brain and spinal cord (the central nervous system) (reference 2); Taken together, our data make a very strong case that the complex molecular mediolateral architecture of the developing trunk CNS (central nervous system), as shared between Platynereis and vertebrates, was already present in their last common ancestor, Urbilateria. The concept of bilaterian nervous system centralization implies that neuron types concentrate on one side of the trunk, as is the case in vertebrates and many invertebrates including Platynereis, where they segregate and become spatially organized (as opposed to a diffuse nerve net). Our data reveal that a large part of the spatial organization of the annelid and vertebrate CNS was already present in their last common ancestor, which implies that Urbilateria had already possessed a CNS (reference 3).[well established][VHOG] XAO:0000215 + FBbt:00005094 cerebrospinal axis CALOHA:TS-0150 @@ -53088,8 +52946,8 @@ pulmonary arterial and venous trees. Examples: There is only one heart.OpenCyc:Mx4rvzYt3pwpEbGdrcN5Y29ycA UBERON:0001017 - UBERON:0001017 cerebrospinal axis + UBERON:0001017 (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...) (reference 1); The neural tube is destined to differentiate into the brain and spinal cord (the central nervous system) (reference 2); Taken together, our data make a very strong case that the complex molecular mediolateral architecture of the developing trunk CNS (central nervous system), as shared between Platynereis and vertebrates, was already present in their last common ancestor, Urbilateria. The concept of bilaterian nervous system centralization implies that neuron types concentrate on one side of the trunk, as is the case in vertebrates and many invertebrates including Platynereis, where they segregate and become spatially organized (as opposed to a diffuse nerve net). Our data reveal that a large part of the spatial organization of the annelid and vertebrate CNS was already present in their last common ancestor, which implies that Urbilateria had already possessed a CNS (reference 3).[well established][VHOG] EHDAA:828 GAID:570 @@ -53101,8 +52959,8 @@ pulmonary arterial and venous trees. Examples: There is only one heart.uberon EMAPA:16470 - TAO:0000012 大脑和脊髓。Kimmel et al, 1995.[TAO] + TAO:0000012 The central nervous system (CNS) is the part of the nervous system which includes the brain, spinal cord, and nerve cell layer of the retina (CUMBO). GAID:570 @@ -53129,12 +52987,12 @@ pulmonary arterial and venous trees. Examples: There is only one heart.脑脊髓轴 - gut tube digestive canal + gut tube 消化道(digestive canal) 肠道 - alimentary canal digestive tube + alimentary canal alimentary tract @@ -53146,12 +53004,12 @@ pulmonary arterial and venous trees. Examples: There is only one heart.从口腔延伸到肛门的管 digestive tract - gut 消化道(alimentary canal) + gut alimentary tract - gut + gut tube digestive tract diff --git a/imports/go_import.owl b/imports/go_import.owl index 2cb446a19..0c697e4cd 100644 --- a/imports/go_import.owl +++ b/imports/go_import.owl @@ -1,6 +1,7 @@ - - 2021-02-01 + + + 2021-06-28 @@ -1976,7 +1978,7 @@ - The vesicular release of dopamine. from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. + The vesicular release of dopamine. from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. dopaminergic synaptic transmission biological_process GO:0001963 @@ -1985,7 +1987,7 @@ - The vesicular release of dopamine. from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. + The vesicular release of dopamine. from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. GOC:dos GOC:dph @@ -2589,7 +2591,7 @@ acquired immune response - ISBN:068340007X + ISBN:068340007X @@ -2624,7 +2626,8 @@ - Any process of the immune system that can potentially contribute to an immune response. + Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation. + https://github.com/geneontology/go-ontology/issues/18737 biological_process GO:0002252 immune effector process @@ -2632,7 +2635,7 @@ - Any process of the immune system that can potentially contribute to an immune response. + Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation. GOC:add GO_REF:0000022 ISBN:0781735149 @@ -3966,9 +3969,9 @@ The formation of nodular inflammatory lesions, usually small or granular, firm, persistent, well-structured, and containing compactly grouped T lymphocytes and modified phagocytes such as epithelioid cells, giant cells, and other macrophages. Granuloma formation represents a chronic inflammatory response initiated by various infectious and noninfectious agents. The center of a granuloma consists of fused macrophages, which can become necrotic. GOC:add GO_REF:0000022 - ISBN:068340007X + ISBN:068340007X ISBN:0721601464 - ISBN:081533642X + ISBN:081533642X @@ -4235,7 +4238,7 @@ The process in which germinal centers form. A germinal center is a specialized microenvironment formed when activated B cells enter lymphoid follicles. Germinal centers are the foci for B cell proliferation and somatic hypermutation. GOC:jal GO_REF:0000022 - ISBN:081533642X + ISBN:081533642X @@ -8799,7 +8802,6 @@ - @@ -8840,7 +8842,6 @@ - @@ -10397,7 +10398,7 @@ - A developmental process in which a progressive change in the state of some part of an organism specifically contributes to its ability to form offspring. + A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring. puberty biological_process reproductive developmental process @@ -10407,7 +10408,7 @@ - A developmental process in which a progressive change in the state of some part of an organism specifically contributes to its ability to form offspring. + A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring. GOC:dph GOC:isa_complete @@ -10987,7 +10988,7 @@ A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. These actions are described from two distinct but related perspectives: (1) biochemical activity, and (2) role as a component in a larger system/process. - GOC:pdt + GOC:pdt @@ -10997,7 +10998,7 @@ - Interacting selectively and non-covalently with any nucleic acid. + Binding to a nucleic acid. GO:0000496 base pairing molecular_function @@ -11011,7 +11012,7 @@ - Interacting selectively and non-covalently with any nucleic acid. + Binding to a nucleic acid. GOC:jl @@ -11126,7 +11127,7 @@ - Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. + Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. receptor binding Wikipedia:Ligand_(biochemistry) receptor ligand @@ -11144,7 +11145,7 @@ - Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. + Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. GOC:bf GOC:ceb ISBN:0198506732 @@ -11229,7 +11230,7 @@ - Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). + Binding to a protein. GO:0001948 GO:0045308 protein amino acid binding @@ -11247,7 +11248,7 @@ - Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). + Binding to a protein. GOC:go_curators @@ -11279,7 +11280,7 @@ A location, relative to cellular compartments and structures, occupied by a macromolecular machine when it carries out a molecular function. There are two ways in which the gene ontology describes locations of gene products: (1) relative to cellular structures (e.g., cytoplasmic side of plasma membrane) or compartments (e.g., mitochondrion), and (2) the stable macromolecular complexes of which they are parts (e.g., the ribosome). - GOC:pdt + GOC:pdt NIF_Subcellular:sao1337158144 @@ -11438,6 +11439,41 @@ + + + + + + + + + + + + + + + + + The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). + GO:0005636 + Wikipedia:Nuclear_envelope + cellular_component + GO:0005635 + + + + nuclear envelope + + + + + The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). + ISBN:0198547684 + + + + @@ -11542,6 +11578,7 @@ A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. + NIF_Subcellular:sao585356902 Wikipedia:Lysosome cellular_component @@ -11633,7 +11670,6 @@ - @@ -11934,7 +11970,7 @@ - + @@ -12090,7 +12126,7 @@ The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars. - ISBN:0192800981 + ISBN:0192800981 @@ -12898,7 +12934,7 @@ A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. GOC:cjm - GOC:dhl + GOC:dhl GOC:ecd GOC:go_curators GOC:mtg_apoptosis @@ -14098,8 +14134,10 @@ The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). + https://github.com/geneontology/go-ontology/issues/21234 biological_process GO:0007275 + Note that this term was 'developmental process'. @@ -14240,13 +14278,7 @@ - - - - - - - + The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement. @@ -14823,7 +14855,7 @@ A biological process represents a specific objective that the organism is genetically programmed to achieve. Biological processes are often described by their outcome or ending state, e.g., the biological process of cell division results in the creation of two daughter cells (a divided cell) from a single parent cell. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence. - GOC:pdt + GOC:pdt @@ -14890,7 +14922,7 @@ - The chemical reactions and pathways involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. + The chemical reactions and pathways involving bile acids, a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. bile acid metabolism biological_process GO:0008206 @@ -14899,7 +14931,7 @@ - The chemical reactions and pathways involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. + The chemical reactions and pathways involving bile acids, a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. GOC:go_curators @@ -15082,7 +15114,7 @@ - Interacting selectively and non-covalently with a lipid. + Binding to a lipid. molecular_function GO:0008289 @@ -15100,7 +15132,7 @@ - Interacting selectively and non-covalently with a lipid. + Binding to a lipid. GOC:ai @@ -15432,7 +15464,6 @@ - @@ -17708,6 +17739,17 @@ + + + + + + + + + + + @@ -17755,11 +17797,8 @@ - - - The controlled release of glutamate by a cell. The glutamate is the most abundant excitatory neurotransmitter in the nervous system. biological_process GO:0014047 @@ -17788,9 +17827,9 @@ + - @@ -17828,7 +17867,7 @@ - + @@ -17871,7 +17910,7 @@ - + @@ -17930,6 +17969,7 @@ + @@ -17970,6 +18010,7 @@ + @@ -18012,6 +18053,7 @@ + @@ -18089,6 +18131,7 @@ + @@ -18128,6 +18171,7 @@ + @@ -18170,6 +18214,7 @@ + @@ -18210,6 +18255,7 @@ + @@ -18317,7 +18363,7 @@ - + @@ -18361,8 +18407,8 @@ + - @@ -18409,8 +18455,8 @@ + - @@ -18446,8 +18492,9 @@ - + + The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0015831 enzyme transport @@ -18499,7 +18546,6 @@ - @@ -18528,29 +18574,6 @@ - - - - - Enables the transfer of an inorganic molecular entity from the outside of a cell to the inside of the cell across a membrane. An inorganic molecular entity is a molecular entity that contains no carbon. - https://github.com/geneontology/go-ontology/issues/14372 - inorganic solute uptake transmembrane transporter activity - inorganic uptake permease activity - molecular_function - GO:0015318 - - inorganic molecular entity transmembrane transporter activity - - - - - Enables the transfer of an inorganic molecular entity from the outside of a cell to the inside of the cell across a membrane. An inorganic molecular entity is a molecular entity that contains no carbon. - GOC:mtg_transport - ISBN:0815340729 - - - - @@ -18649,6 +18672,7 @@ + The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. biological_process @@ -18923,25 +18947,6 @@ - - - - - - The directed movement of fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. - biological_process - GO:0015908 - fatty acid transport - - - - - The directed movement of fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. - GOC:ai - - - - @@ -20465,7 +20470,7 @@ - Interacting selectively and non-covalently with major histocompatibility complex class Ib molecules. + Binding to a major histocompatibility complex class Ib molecules. 2010-02-16T09:30:50Z molecular_function GO:0023029 @@ -20474,7 +20479,7 @@ - Interacting selectively and non-covalently with major histocompatibility complex class Ib molecules. + Binding to a major histocompatibility complex class Ib molecules. GOC:mtg_signal GOC:vw @@ -20724,8 +20729,6 @@ The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism. Wikipedia:Myofibril cellular_component - striated muscle fiber - striated muscle fibre GO:0030016 myofibril @@ -21407,7 +21410,7 @@ The chemical reactions and pathways involving glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars. Formerly known as mucopolysaccharides, they include hyaluronic acid and chondroitin, which provide lubrication in joints and form part of the matrix of cartilage. The three-dimensional structure of these molecules enables them to trap water, which forms a gel and gives glycosaminoglycans their elastic properties. - ISBN:0192800981 + ISBN:0192800981 @@ -22024,6 +22027,17 @@ + + + + + + + + + + + @@ -22374,6 +22388,17 @@ + + + + + + + + + + + @@ -22404,6 +22429,26 @@ + + + + + The regrowth of a lost or destroyed body part, such as an organ or tissue. This process may occur via renewal, repair, and/or growth alone (i.e. increase in size or mass). + Wikipedia:Regeneration_(biology) + biological_process + GO:0031099 + regeneration + + + + + The regrowth of a lost or destroyed body part, such as an organ or tissue. This process may occur via renewal, repair, and/or growth alone (i.e. increase in size or mass). + GOC:mah + GOC:pr + + + + @@ -23258,7 +23303,7 @@ A vesicle found in the cytoplasm of a cell. GOC:ai GOC:mah - GOC:vesicles + GOC:vesicles @@ -23266,7 +23311,7 @@ - + A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location. establishment and maintenance of protein complex localization protein complex localisation @@ -23442,6 +23487,75 @@ + + + + + + + + + + + + + + + + + + + + + + Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. + NIF_Subcellular:sao1687101204 + cellular_component + GO:0031965 + nuclear membrane + + + + + Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. + GOC:mah + GOC:pz + + + + + + + + + + + + + + + + + + + + + A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes. + cellular_component + GO:0031967 + + organelle envelope + + + + + A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes. + GOC:mah + GOC:pz + + + + @@ -23461,10 +23575,28 @@ + + + + + A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers. + cellular_component + GO:0031975 + envelope + + + + + A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers. + GOC:mah + GOC:pz + + + + - @@ -23508,7 +23640,7 @@ Any small, fluid-filled, spherical organelle enclosed by membrane. GOC:mah GOC:pz - GOC:vesicles + GOC:vesicles @@ -24504,7 +24636,7 @@ - + @@ -24541,7 +24673,7 @@ - + @@ -24582,7 +24714,7 @@ - + @@ -25273,8 +25405,13 @@ - + + + + + + The directed movement of a protein from one location to another within a lipid bilayer. protein translocation within membrane receptor translocation within membrane @@ -25314,8 +25451,8 @@ The appearance of type I interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. GOC:add - ISBN:0126896631 - PMID:15546383 + ISBN:0126896631 + PMID:15546383 PMID:16681834 @@ -25350,7 +25487,7 @@ The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon. GOC:add GOC:mah - PMID:15546383 + PMID:15546383 @@ -25772,7 +25909,7 @@ Any process that modulates the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. GOC:add GOC:mah - PMID:15546383 + PMID:15546383 @@ -26358,7 +26495,7 @@ Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. GOC:add GOC:mah - PMID:15546383 + PMID:15546383 @@ -27018,7 +27155,7 @@ Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. GOC:add GOC:mah - PMID:15546383 + PMID:15546383 @@ -28071,7 +28208,7 @@ - + @@ -28107,7 +28244,7 @@ - + @@ -28147,7 +28284,7 @@ - + @@ -29260,6 +29397,7 @@ + @@ -29300,6 +29438,7 @@ + @@ -31193,6 +31332,76 @@ + + + + + The increase in size or mass of an entire organism, a part of an organism or a cell. + GO:0048590 + biological_process + growth pattern + non-developmental growth + GO:0040007 + + + + + + See also the biological process term 'cell growth ; GO:0016049'. + growth + + + + + The increase in size or mass of an entire organism, a part of an organism or a cell. + GOC:bf + GOC:ma + + + + + non-developmental growth + GOC:mah + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development. + biological_process + GO:0040008 + regulation of growth + + + + + Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development. + GOC:ems + GOC:mah + + + + @@ -31380,6 +31589,12 @@ + + + + + + The series of events that restore integrity to a damaged tissue, following an injury. Wikipedia:Wound_healing biological_process @@ -31399,8 +31614,8 @@ + - @@ -31899,6 +32114,25 @@ + + + + + + The regrowth of lost or destroyed tissues. + biological_process + GO:0042246 + tissue regeneration + + + + + The regrowth of lost or destroyed tissues. + GOC:curators + + + + @@ -31978,7 +32212,7 @@ - Interacting selectively and non-covalently with major histocompatibility complex molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. + Binding to a major histocompatibility complex molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. major histocompatibility complex binding major histocompatibility complex ligand molecular_function @@ -31989,7 +32223,7 @@ - Interacting selectively and non-covalently with major histocompatibility complex molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. + Binding to a major histocompatibility complex molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. GOC:jl @@ -32017,7 +32251,7 @@ The directed movement of a motile cell or organism in response to an external stimulus. GOC:jl - ISBN:0192801023 + ISBN:0192801023 @@ -33385,7 +33619,7 @@ - Interacting selectively and non-covalently with glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide. + Binding to glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide. molecular_function GO:0043208 glycosphingolipid binding @@ -33393,7 +33627,7 @@ - Interacting selectively and non-covalently with glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide. + Binding to glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide. GOC:jl @@ -33425,7 +33659,24 @@ + + + + + + + + + + + + + + + + + Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. NIF_Subcellular:sao414196390 membrane-enclosed organelle @@ -33465,7 +33716,24 @@ - + + + + + + + + + + + + + + + + + + Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. cellular_component GO:0043229 @@ -33521,6 +33789,17 @@ + + + + + + + + + + + Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. @@ -33555,12 +33834,6 @@ - - - - - - Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes. intracellular non-membrane-enclosed organelle cellular_component @@ -33633,6 +33906,37 @@ + + + + + + + + + + + + + + + + + Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring outside the cell. + extracellular non-membrane-enclosed organelle + cellular_component + GO:0043264 + extracellular non-membrane-bounded organelle + + + + + Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring outside the cell. + GOC:jl + + + + @@ -33790,8 +34094,6 @@ Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle. - muscle fiber - muscle fibre contractile fibre cellular_component GO:0043292 @@ -34480,113 +34782,6 @@ - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species. - biological_process - GO:0043900 - regulation of multi-organism process - - - - - Any process that modulates the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species. - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species. - biological_process - GO:0043901 - negative regulation of multi-organism process - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species. - GOC:jl - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species. - biological_process - GO:0043902 - positive regulation of multi-organism process - - - - - Any process that activates or increases the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species. - GOC:jl - - - - @@ -34931,60 +35126,6 @@ - - - - - - - - - - - - - - - - - - - - - - The progression of an organism from an initial condition to a later condition, occurring when the organism is in a symbiotic interaction. - jl - 2009-07-30T02:26:46Z - GO:0044152 - development on or near surface of other organism involved in symbiotic interaction - biological_process - development during symbiotic interaction - development on or near surface of other organism during symbiotic interaction - GO:0044111 - development involved in symbiotic interaction - - - - - The progression of an organism from an initial condition to a later condition, occurring when the organism is in a symbiotic interaction. - GO:jl - GOC:pamgo_curators - - - - - development during symbiotic interaction - gOC:dph - - - - - development on or near surface of other organism during symbiotic interaction - GOC:dph - - - - @@ -35208,7 +35349,70 @@ Any process evolved to enable an interaction with an organism of a different species. - GOC:cc + GOC:cc + + + + + + + + + The aggregation, arrangement and bonding together of a set of components to form a motile cilium. + krc + 2015-02-06T17:23:23Z + GO:1903887 + biological_process + motile primary cilia assembly + motile primary cilia formation + motile primary cilium assembly + motile primary cilium formation + nodal cilium assembly + nodal cilium formation + GO:0044458 + motile cilium assembly + + + + + The aggregation, arrangement and bonding together of a set of components to form a motile cilium. + GOC:TermGenie + GOC:cilia + GOC:krc + GO_REF:0000079 + PMID:19776033 + PMID:21129373 + ZFIN:dsf + + + + + motile primary cilia assembly + GOC:TermGenie + + + + + motile primary cilia formation + GOC:TermGenie + + + + + motile primary cilium formation + GOC:TermGenie + + + + + nodal cilium assembly + GOC:TermGenie + + + + + nodal cilium formation + GOC:TermGenie @@ -35357,7 +35561,6 @@ - Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. @@ -39361,6 +39564,87 @@ + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism. + down regulation of growth + down-regulation of growth + downregulation of growth + inhibition of growth + biological_process + GO:0045926 + negative regulation of growth + + + + + Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism. + up regulation of growth + up-regulation of growth + upregulation of growth + activation of growth + stimulation of growth + biological_process + GO:0045927 + positive regulation of growth + + + + + Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism. + GOC:go_curators + + + + @@ -40146,7 +40430,7 @@ - Interacting selectively and non-covalently with sphingolipids, a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). + Binding to a sphingolipid, a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). molecular_function GO:0046625 sphingolipid binding @@ -40154,7 +40438,7 @@ - Interacting selectively and non-covalently with sphingolipids, a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). + Binding to a sphingolipid, a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). ISBN:0198506732 @@ -42320,6 +42604,25 @@ + + + + + + The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another. + biological_process + GO:0048589 + developmental growth + + + + + The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another. + GOC:go_curators + + + + @@ -42331,7 +42634,7 @@ - The reproductive developmental process whose specific outcome is the progression of structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures. + The reproductive developmental process whose specific outcome is the progression of somatic structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures. biological_process GO:0048608 reproductive structure development @@ -42339,7 +42642,7 @@ - The reproductive developmental process whose specific outcome is the progression of structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures. + The reproductive developmental process whose specific outcome is the progression of somatic structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures. GOC:dph GOC:isa_complete GOC:jid @@ -42375,6 +42678,125 @@ + + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of developmental growth. + biological_process + GO:0048638 + regulation of developmental growth + + + + + Any process that modulates the frequency, rate or extent of developmental growth. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates, maintains or increases the rate of developmental growth. + up regulation of developmental growth + up-regulation of developmental growth + upregulation of developmental growth + activation of developmental growth + stimulation of developmental growth + biological_process + GO:0048639 + positive regulation of developmental growth + + + + + Any process that activates, maintains or increases the rate of developmental growth. + GOC:go_curators + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth. + down regulation of developmental growth + down-regulation of developmental growth + downregulation of developmental growth + inhibition of developmental growth + biological_process + GO:0048640 + negative regulation of developmental growth + + + + + Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth. + GOC:go_curators + + + + @@ -42976,7 +43398,6 @@ - @@ -43013,7 +43434,6 @@ - @@ -43055,7 +43475,6 @@ - @@ -43899,7 +44318,7 @@ - Interacting selectively and non-covalently with a cell adhesion molecule. + Binding to a cell adhesion molecule. CAM binding molecular_function adhesive extracellular matrix constituent @@ -43911,7 +44330,7 @@ - Interacting selectively and non-covalently with a cell adhesion molecule. + Binding to a cell adhesion molecule. GOC:ai @@ -46431,8 +46850,8 @@ + - @@ -46473,8 +46892,8 @@ + - @@ -46509,8 +46928,8 @@ + - @@ -47931,52 +48350,6 @@ - - - - - - - - - - - - - - - - - - - - - - Any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane. - establishment and maintenance of localization in membrane - establishment and maintenance of position in membrane - localisation within membrane - localization to membrane - positioning within membrane - biological_process - GO:0051668 - localization within membrane - - - - - Any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane. - GOC:ai - - - - - localisation within membrane - GOC:mah - - - - @@ -48096,12 +48469,23 @@ Any process that modulates the rate or extent of progression through the cell cycle. GO:0000074 + GO:0007050 + GO:0071156 + GO:0071157 + GO:0071158 + GO:0071850 cell cycle modulation cell cycle regulation control of cell cycle progression modulation of cell cycle progression regulation of cell cycle progression regulation of progression through cell cycle + arrest of mitotic cell cycle progression + cell cycle arrest + mitotic cell cycle arrest + negative regulation of cell cycle arrest + positive regulation of cell cycle arrest + regulation of cell cycle arrest biological_process cell cycle regulator tumor suppressor @@ -48117,6 +48501,12 @@ GOC:dph GOC:tb + + + + arrest of mitotic cell cycle progression + GOC:mah + @@ -48578,7 +48968,7 @@ - Interacting selectively and non-covalently with a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic group such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate. + Binding to a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic group such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate. molecular_function GO:0051861 glycolipid binding @@ -48586,7 +48976,7 @@ - Interacting selectively and non-covalently with a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic group such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate. + Binding to a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic group such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate. PMID:19635802 @@ -48684,7 +49074,7 @@ - + @@ -48719,8 +49109,8 @@ + - @@ -48759,8 +49149,8 @@ + - @@ -49532,7 +49922,7 @@ A compound molecular function in which an effector function is controlled by one or more regulatory components. GOC:dos - GOC:pdt + GOC:pdt @@ -50801,7 +51191,6 @@ - @@ -50909,6 +51298,50 @@ + + + + + + + + + + + + + + + + + + + + + + The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape. + dph + 2009-04-28T08:42:53Z + differential growth + biological_process + GO:0060560 + developmental growth involved in morphogenesis + + + + + The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape. + GOC:dph + + + + + differential growth + GOC:dph + + + + @@ -51945,6 +52378,37 @@ + + + + + + + + + + + + + + + + + Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell. + extracellular membrane-enclosed organelle + cellular_component + GO:0065010 + extracellular membrane-bounded organelle + + + + + Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell. + GOC:isa_complete + + + + @@ -51959,7 +52423,7 @@ - + @@ -52434,8 +52898,6 @@ - - The regulated release of mucus by the mucosa. Mucus is a viscous slimy secretion consisting of mucins and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes. The mucosa, or mucous membrane, is the membrane covered with epithelium that lines the tubular organs of the body. Mucins are carbohydrate-rich glycoproteins that have a lubricating and protective function. mucus production biological_process @@ -52447,7 +52909,7 @@ The regulated release of mucus by the mucosa. Mucus is a viscous slimy secretion consisting of mucins and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes. The mucosa, or mucous membrane, is the membrane covered with epithelium that lines the tubular organs of the body. Mucins are carbohydrate-rich glycoproteins that have a lubricating and protective function. GOC:add - ISBN:068340007X + ISBN:068340007X ISBN:0721662544 @@ -52473,7 +52935,6 @@ - @@ -52521,7 +52982,6 @@ - @@ -52566,7 +53026,6 @@ - @@ -53750,7 +54209,7 @@ - + The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon. mah 2010-03-08T02:15:14Z @@ -54464,7 +54923,7 @@ extracellular vesicular exosome assembly - GOC:vesicles + GOC:vesicles @@ -54647,7 +55106,7 @@ Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). - GOC:dhl + GOC:dhl @@ -54666,7 +55125,6 @@ - @@ -54982,7 +55440,7 @@ - + @@ -55640,7 +56098,7 @@ The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. - CL:0000451 + CL:0000451 GOC:pr @@ -55721,7 +56179,7 @@ Any process that activates or increases the frequency, rate or extent of inhibitory postsynaptic potential (IPSP). IPSP is a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential. GOC:BHF - GOC:sjp + GOC:sjp PMID:18550748 @@ -55731,7 +56189,7 @@ - Interacting selectively and non-covalently with an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure. + Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure. pr 2011-09-23T02:31:01Z molecular_function @@ -55741,7 +56199,7 @@ - Interacting selectively and non-covalently with an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure. + Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure. GOC:sjw PMID:7583672 @@ -55812,7 +56270,7 @@ - Interacting selectively and non-covalently with a carbohydrate derivative. + Binding to a carbohydrate derivative. pr 2012-08-02T13:03:39Z molecular_function @@ -55824,7 +56282,7 @@ - Interacting selectively and non-covalently with a carbohydrate derivative. + Binding to a carbohydrate derivative. GOC:pr @@ -55845,7 +56303,7 @@ The movement of a myeloid leukocyte within or between different tissues and organs of the body. - GOC:cvs + GOC:cvs PMID:22342843 PMID:24157461 @@ -55867,7 +56325,7 @@ The movement of a granulocyte within or between different tissues and organs of the body. - GOC:cvs + GOC:cvs PMID:24163421 PMID:24193336 @@ -55889,12 +56347,7 @@ - - - - - - + Any vesicle that is part of the intracellular region. pr 2016-03-29T17:39:45Z @@ -55906,7 +56359,7 @@ Any vesicle that is part of the intracellular region. - GOC:vesicles + GOC:vesicles @@ -55994,33 +56447,14 @@ - - - - - Nucleus with two or more lobes connected by a thin filament that contains no internal chromatin. Examples include the nuclei of mature basophils, eosinophils and neutrophils in mice and humans. - dos - 2013-10-22T18:31:36Z - cellular_component - GO:0098537 - lobed nucleus - - - - - Nucleus with two or more lobes connected by a thin filament that contains no internal chromatin. Examples include the nuclei of mature basophils, eosinophils and neutrophils in mice and humans. - GOC:dos - GOC:tfm - - - - + Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism. + https://github.com/geneontology/go-ontology/issues/18737 dos 2013-11-11T12:59:11Z GO:0009814 @@ -56519,27 +56953,6 @@ - - - - - - - The directed movement of a protein along a microtubule, mediated by motor proteins. - microtubule-based protein transport - biological_process - GO:0098840 - protein transport along microtubule - - - - - The directed movement of a protein along a microtubule, mediated by motor proteins. - PMID:25987607 - - - - @@ -56816,25 +57229,6 @@ - - - - - - A microtubule-based process that results in the transport of proteins. - biological_process - GO:0099118 - microtubule-based protein transport - - - - - A microtubule-based process that results in the transport of proteins. - GOC:vw - - - - @@ -58182,6 +58576,41 @@ + + + + + + + + + + + + + + + + + + + The assembly and organization of the sperm flagellum, the microtubule-based axoneme and associated structures that are part of a sperm flagellum (or cilium). + krc + 2021-04-29T01:27:27Z + biological_process + GO:0120316 + sperm flagellum assembly + + + + + The assembly and organization of the sperm flagellum, the microtubule-based axoneme and associated structures that are part of a sperm flagellum (or cilium). + GOC:krc + PMID:32791035 + + + + @@ -59724,6 +60153,7 @@ + @@ -59829,6 +60259,7 @@ + @@ -60089,6 +60520,7 @@ + @@ -60428,28 +60860,6 @@ - - - - - The directed movement of a carbohydrate derivative into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - bf - 2012-08-16T14:51:22Z - biological_process - GO:1901264 - carbohydrate derivative transport - - - - - The directed movement of a carbohydrate derivative into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. - GOC:TermGenie - GOC:bf - GOC:jl - - - - @@ -60830,7 +61240,7 @@ - Interacting selectively and non-covalently with heterocyclic compound. + Binding to heterocyclic compound. bf 2012-09-14T13:53:50Z molecular_function @@ -60840,7 +61250,7 @@ - Interacting selectively and non-covalently with heterocyclic compound. + Binding to heterocyclic compound. GOC:TermGenie @@ -66418,7 +66828,7 @@ regulation of extracellular vesicular exosome assembly - GOC:vesicles + GOC:vesicles @@ -66487,7 +66897,7 @@ negative regulation of extracellular vesicular exosome assembly - GOC:vesicles + GOC:vesicles @@ -66568,7 +66978,7 @@ positive regulation of extracellular vesicular exosome assembly - GOC:vesicles + GOC:vesicles @@ -66917,7 +67327,7 @@ - + Any vesicle that is part of the extracellular region. jl 2014-10-22T14:26:11Z @@ -66939,7 +67349,7 @@ microparticle - GOC:vesicles + GOC:vesicles @@ -69577,6 +69987,7 @@ + @@ -69621,6 +70032,7 @@ + @@ -69691,6 +70103,7 @@ + @@ -70019,7 +70432,7 @@ - + @@ -73256,6 +73669,575 @@ + + + + + + + + + + + + + + + + + + + + + + Any process that modulates the frequency, rate or extent of motile cilium assembly. + krc + 2016-09-27T18:27:47Z + biological_process + regulation of motile primary cilia assembly + regulation of motile primary cilia formation + regulation of motile primary cilium assembly + regulation of motile primary cilium formation + regulation of nodal cilium assembly + regulation of nodal cilium formation + GO:1905503 + regulation of motile cilium assembly + + + + + Any process that modulates the frequency, rate or extent of motile cilium assembly. + GOC:TermGenie + GOC:cilia + GOC:krc + GO_REF:0000058 + PMID:25294941 + + + + + regulation of motile primary cilia assembly + GOC:TermGenie + + + + + regulation of motile primary cilia formation + GOC:TermGenie + + + + + regulation of motile primary cilium formation + GOC:TermGenie + + + + + regulation of nodal cilium assembly + GOC:TermGenie + + + + + regulation of nodal cilium formation + GOC:TermGenie + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of motile cilium assembly. + krc + 2016-09-27T18:27:55Z + inhibition of motile primary cilia assembly + inhibition of motile primary cilia formation + inhibition of motile primary cilium assembly + inhibition of motile primary cilium formation + biological_process + down regulation of motile primary cilia assembly + down regulation of motile primary cilia formation + down regulation of motile primary cilium assembly + down regulation of motile primary cilium formation + down regulation of nodal cilium assembly + down regulation of nodal cilium formation + down-regulation of motile primary cilia assembly + down-regulation of motile primary cilia formation + down-regulation of motile primary cilium assembly + down-regulation of motile primary cilium formation + down-regulation of nodal cilium assembly + down-regulation of nodal cilium formation + downregulation of motile primary cilia assembly + downregulation of motile primary cilia formation + downregulation of motile primary cilium assembly + downregulation of motile primary cilium formation + downregulation of nodal cilium assembly + downregulation of nodal cilium formation + inhibition of nodal cilium assembly + inhibition of nodal cilium formation + negative regulation of motile primary cilia assembly + negative regulation of motile primary cilia formation + negative regulation of motile primary cilium assembly + negative regulation of motile primary cilium formation + negative regulation of nodal cilium assembly + negative regulation of nodal cilium formation + GO:1905504 + negative regulation of motile cilium assembly + + + + + Any process that stops, prevents or reduces the frequency, rate or extent of motile cilium assembly. + GOC:TermGenie + GOC:cilia + GOC:krc + GO_REF:0000058 + PMID:25294941 + + + + + inhibition of motile primary cilia assembly + GOC:TermGenie + + + + + inhibition of motile primary cilia formation + GOC:TermGenie + + + + + inhibition of motile primary cilium assembly + GOC:TermGenie + + + + + inhibition of motile primary cilium formation + GOC:TermGenie + + + + + down regulation of motile primary cilia assembly + GOC:TermGenie + + + + + down regulation of motile primary cilia formation + GOC:TermGenie + + + + + down regulation of motile primary cilium assembly + GOC:TermGenie + + + + + down regulation of motile primary cilium formation + GOC:TermGenie + + + + + down regulation of nodal cilium assembly + GOC:TermGenie + + + + + down regulation of nodal cilium formation + GOC:TermGenie + + + + + down-regulation of motile primary cilia assembly + GOC:TermGenie + + + + + down-regulation of motile primary cilia formation + GOC:TermGenie + + + + + down-regulation of motile primary cilium assembly + GOC:TermGenie + + + + + down-regulation of motile primary cilium formation + GOC:TermGenie + + + + + down-regulation of nodal cilium assembly + GOC:TermGenie + + + + + down-regulation of nodal cilium formation + GOC:TermGenie + + + + + downregulation of motile primary cilia assembly + GOC:TermGenie + + + + + downregulation of motile primary cilia formation + GOC:TermGenie + + + + + downregulation of motile primary cilium assembly + GOC:TermGenie + + + + + downregulation of motile primary cilium formation + GOC:TermGenie + + + + + downregulation of nodal cilium assembly + GOC:TermGenie + + + + + downregulation of nodal cilium formation + GOC:TermGenie + + + + + inhibition of nodal cilium assembly + GOC:TermGenie + + + + + inhibition of nodal cilium formation + GOC:TermGenie + + + + + negative regulation of motile primary cilia assembly + GOC:TermGenie + + + + + negative regulation of motile primary cilia formation + GOC:TermGenie + + + + + negative regulation of motile primary cilium formation + GOC:TermGenie + + + + + negative regulation of nodal cilium assembly + GOC:TermGenie + + + + + negative regulation of nodal cilium formation + GOC:TermGenie + + + + + + + + + + + + + + + + + + + + + + + + + + + Any process that activates or increases the frequency, rate or extent of motile cilium assembly. + krc + 2016-09-27T18:28:03Z + activation of motile primary cilia assembly + activation of motile primary cilia formation + activation of motile primary cilium assembly + activation of motile primary cilium formation + biological_process + activation of nodal cilium assembly + activation of nodal cilium formation + positive regulation of motile primary cilia assembly + positive regulation of motile primary cilia formation + positive regulation of motile primary cilium assembly + positive regulation of motile primary cilium formation + positive regulation of nodal cilium assembly + positive regulation of nodal cilium formation + up regulation of motile primary cilia assembly + up regulation of motile primary cilia formation + up regulation of motile primary cilium assembly + up regulation of motile primary cilium formation + up regulation of nodal cilium assembly + up regulation of nodal cilium formation + up-regulation of motile primary cilia assembly + up-regulation of motile primary cilia formation + up-regulation of motile primary cilium assembly + up-regulation of motile primary cilium formation + up-regulation of nodal cilium assembly + up-regulation of nodal cilium formation + upregulation of motile primary cilia assembly + upregulation of motile primary cilia formation + upregulation of motile primary cilium assembly + upregulation of motile primary cilium formation + upregulation of nodal cilium assembly + upregulation of nodal cilium formation + GO:1905505 + positive regulation of motile cilium assembly + + + + + Any process that activates or increases the frequency, rate or extent of motile cilium assembly. + GOC:TermGenie + GOC:cilia + GOC:krc + GO_REF:0000058 + PMID:25294941 + + + + + activation of motile primary cilia assembly + GOC:TermGenie + + + + + activation of motile primary cilia formation + GOC:TermGenie + + + + + activation of motile primary cilium assembly + GOC:TermGenie + + + + + activation of motile primary cilium formation + GOC:TermGenie + + + + + activation of nodal cilium assembly + GOC:TermGenie + + + + + activation of nodal cilium formation + GOC:TermGenie + + + + + positive regulation of motile primary cilia assembly + GOC:TermGenie + + + + + positive regulation of motile primary cilia formation + GOC:TermGenie + + + + + positive regulation of motile primary cilium formation + GOC:TermGenie + + + + + positive regulation of nodal cilium assembly + GOC:TermGenie + + + + + positive regulation of nodal cilium formation + GOC:TermGenie + + + + + up regulation of motile primary cilia assembly + GOC:TermGenie + + + + + up regulation of motile primary cilia formation + GOC:TermGenie + + + + + up regulation of motile primary cilium assembly + GOC:TermGenie + + + + + up regulation of motile primary cilium formation + GOC:TermGenie + + + + + up regulation of nodal cilium assembly + GOC:TermGenie + + + + + up regulation of nodal cilium formation + GOC:TermGenie + + + + + up-regulation of motile primary cilia assembly + GOC:TermGenie + + + + + up-regulation of motile primary cilia formation + GOC:TermGenie + + + + + up-regulation of motile primary cilium assembly + GOC:TermGenie + + + + + up-regulation of motile primary cilium formation + GOC:TermGenie + + + + + up-regulation of nodal cilium assembly + GOC:TermGenie + + + + + up-regulation of nodal cilium formation + GOC:TermGenie + + + + + upregulation of motile primary cilia assembly + GOC:TermGenie + + + + + upregulation of motile primary cilia formation + GOC:TermGenie + + + + + upregulation of motile primary cilium assembly + GOC:TermGenie + + + + + upregulation of motile primary cilium formation + GOC:TermGenie + + + + + upregulation of nodal cilium assembly + GOC:TermGenie + + + + + upregulation of nodal cilium formation + GOC:TermGenie + + + + @@ -73270,7 +74252,6 @@ - @@ -75430,122 +76411,6 @@ - - - - - - - - - - - - - - - - - - - - - - - Any process that modulates the frequency, rate or extent of fatty acid transport. - rl - 2010-10-18T10:37:13Z - biological_process - GO:2000191 - regulation of fatty acid transport - - - - - Any process that modulates the frequency, rate or extent of fatty acid transport. - GOC:BHF - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid transport. - rl - 2010-10-18T10:37:15Z - biological_process - GO:2000192 - negative regulation of fatty acid transport - - - - - Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid transport. - GOC:BHF - - - - - - - - - - - - - - - - - - - - - - - - - - - - Any process that activates or increases the frequency, rate or extent of fatty acid transport. - rl - 2010-10-18T10:37:17Z - biological_process - GO:2000193 - positive regulation of fatty acid transport - - - - - Any process that activates or increases the frequency, rate or extent of fatty acid transport. - GOC:BHF - - - - diff --git a/imports/ncbitaxon_import.obo b/imports/ncbitaxon_import.obo index 7fd3e1eba..82bd601e4 100644 --- a/imports/ncbitaxon_import.obo +++ b/imports/ncbitaxon_import.obo @@ -1,3733 +1,318 @@ format-version: 1.2 -data-version: cl/releases/2019-02-21/imports/ncbitaxon_import.owl +data-version: cl/releases/2020-11-17/imports/ncbitaxon_import.owl ontology: cl/imports/ncbitaxon_import +property_value: owl:versionInfo "2020-11-17" xsd:string [Term] id: NCBITaxon:1 name: root -namespace: ncbi_taxonomy -synonym: "all" RELATED synonym [] xref: GC_ID:1 [Term] id: NCBITaxon:10066 name: Muridae -namespace: ncbi_taxonomy xref: GC_ID:1 xref: PMID:15371245 is_a: NCBITaxon:337687 ! Muroidea -property_value: has_rank NCBITaxon:family [Term] id: NCBITaxon:10088 -name: Mus -namespace: ncbi_taxonomy -synonym: "mice" EXACT common_name [] -synonym: "mouse" EXACT common_name [] -synonym: "Mus" EXACT scientific_name [] +name: Mus xref: GC_ID:1 is_a: NCBITaxon:39107 ! Murinae -property_value: has_rank NCBITaxon:genus [Term] id: NCBITaxon:10090 name: Mus musculus -namespace: ncbi_taxonomy -alt_id: NCBITaxon:85055 -synonym: "house mouse" EXACT genbank_common_name [] -synonym: "mice C57BL/6xCBA/CaJ hybrid" RELATED misspelling [] -synonym: "mouse" EXACT common_name [] -synonym: "Mus muscaris" RELATED misnomer [] xref: GC_ID:1 -is_a: NCBITaxon:862507 ! Mus -property_value: has_rank NCBITaxon:species - -[Term] -id: NCBITaxon:10114 -name: Rattus -namespace: ncbi_taxonomy -synonym: "rat" EXACT common_name [] -synonym: "rats" EXACT common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:39107 ! Murinae -property_value: has_rank NCBITaxon:genus - -[Term] -id: NCBITaxon:10116 -name: Rattus norvegicus -namespace: ncbi_taxonomy -alt_id: NCBITaxon:36465 -synonym: "brown rat" EXACT common_name [] -synonym: "Gunn rats" RELATED misnomer [] -synonym: "Norway rat" EXACT genbank_common_name [] -synonym: "rat" EXACT common_name [] -synonym: "rats" EXACT common_name [] -synonym: "Rattus norvegicus8" RELATED misspelling [] -synonym: "Rattus norwegicus" RELATED misspelling [] -synonym: "Rattus rattiscus" RELATED misnomer [] -synonym: "Rattus sp. strain Wistar" EXACT equivalent_name [] -xref: GC_ID:1 -is_a: NCBITaxon:10114 ! Rattus -property_value: has_rank NCBITaxon:species - -[Term] -id: NCBITaxon:10205 -name: Bryozoa -namespace: ncbi_taxonomy -synonym: "bryozoans" EXACT genbank_common_name [] -synonym: "bryozoans" RELATED blast_name [] -synonym: "Ectoprocta" RELATED synonym [] -xref: GC_ID:1 -is_a: NCBITaxon:1206795 ! Lophotrochozoa -property_value: has_rank NCBITaxon:phylum - -[Term] -id: NCBITaxon:10206 -name: Gymnolaemata -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:10205 ! Bryozoa -property_value: has_rank NCBITaxon:class - -[Term] -id: NCBITaxon:10219 -name: Hemichordata -namespace: ncbi_taxonomy -synonym: "hemichordates" EXACT genbank_common_name [] -synonym: "hemichordates" RELATED blast_name [] -xref: GC_ID:1 -is_a: NCBITaxon:33511 ! Deuterostomia -property_value: has_rank NCBITaxon:phylum - -[Term] -id: NCBITaxon:10239 -name: Viruses -namespace: ncbi_taxonomy -synonym: "Vira" RELATED synonym [] -synonym: "Viridae" RELATED synonym [] -synonym: "viruses" RELATED blast_name [] -xref: GC_ID:1 -is_a: NCBITaxon:1 ! root -property_value: has_rank NCBITaxon:superkingdom - -[Term] -id: NCBITaxon:104431 -name: Obtectomera -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:37567 ! Ditrysia - -[Term] -id: NCBITaxon:105389 -name: Palpata -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:6341 ! Polychaeta -property_value: has_rank NCBITaxon:subclass - -[Term] -id: NCBITaxon:105390 -name: Aciculata -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:105389 ! Palpata -property_value: has_rank NCBITaxon:infraclass - -[Term] -id: NCBITaxon:105391 -name: Canalipalpata -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:105389 ! Palpata -property_value: has_rank NCBITaxon:infraclass - -[Term] -id: NCBITaxon:110551 -name: Myxininae -namespace: ncbi_taxonomy -alt_id: NCBITaxon:7768 -xref: GC_ID:1 -is_a: NCBITaxon:7762 ! Myxinidae -property_value: has_rank NCBITaxon:subfamily - -[Term] -id: NCBITaxon:110555 -name: Myxine -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:110551 ! Myxininae -property_value: has_rank NCBITaxon:genus - -[Term] -id: NCBITaxon:110814 -name: Xenoturbellida -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:1312402 ! Xenacoelomorpha -property_value: has_rank NCBITaxon:subphylum - -[Term] -id: NCBITaxon:110815 -name: Xenoturbella -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:1547233 ! Xenoturbellidae -property_value: has_rank NCBITaxon:genus - -[Term] -id: NCBITaxon:117565 -name: Hyperotreti -namespace: ncbi_taxonomy -synonym: "Agnatha" RELATED in_part [] -synonym: "fish" EXACT common_name [] -synonym: "fishes" EXACT common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:1476529 ! Cyclostomata - -[Term] -id: NCBITaxon:117569 -name: Hyperoartia -namespace: ncbi_taxonomy -synonym: "Agnatha" RELATED in_part [] -synonym: "Cephalaspidomorphi" RELATED in_part [] -synonym: "fish" EXACT common_name [] -synonym: "fishes" EXACT common_name [] -synonym: "Monorhina" RELATED in_part [] -xref: GC_ID:1 -is_a: NCBITaxon:1476529 ! Cyclostomata +is_a: NCBITaxon:862507 ! Mus [Term] id: NCBITaxon:117570 name: Teleostomi -namespace: ncbi_taxonomy xref: GC_ID:1 -is_a: NCBITaxon:7776 ! Gnathostomata +is_a: NCBITaxon:7776 ! Gnathostomata [Term] id: NCBITaxon:117571 name: Euteleostomi -namespace: ncbi_taxonomy -alt_id: NCBITaxon:40673 -synonym: "bony vertebrates" EXACT genbank_common_name [] xref: GC_ID:1 is_a: NCBITaxon:117570 ! Teleostomi -[Term] -id: NCBITaxon:117893 -name: Batoidea -namespace: ncbi_taxonomy -synonym: "rays" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:7778 ! Elasmobranchii -property_value: has_rank NCBITaxon:superorder - -[Term] -id: NCBITaxon:118072 -name: Coelacanthimorpha -namespace: ncbi_taxonomy -synonym: "Actinistia" RELATED synonym [] -synonym: "Choanichthyes" RELATED in_part [] -synonym: "Crossopterygii" RELATED in_part [] -synonym: "fish" EXACT common_name [] -synonym: "fishes" EXACT common_name [] -synonym: "lobe-finned fishes" EXACT common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:8287 ! Sarcopterygii - -[Term] -id: NCBITaxon:119089 -name: Chromadorea -namespace: ncbi_taxonomy -alt_id: NCBITaxon:27837 -synonym: "Adenophorea" RELATED synonym [] -xref: GC_ID:1 -is_a: NCBITaxon:6231 ! Nematoda -property_value: has_rank NCBITaxon:class - [Term] id: NCBITaxon:1206794 name: Ecdysozoa -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:33317 ! Protostomia - -[Term] -id: NCBITaxon:1206795 -name: Lophotrochozoa -namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:33317 ! Protostomia -[Term] -id: NCBITaxon:123365 -name: Neoteleostei -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:1489388 ! Euteleosteomorpha - -[Term] -id: NCBITaxon:123366 -name: Eurypterygia -namespace: ncbi_taxonomy -synonym: "Eurypterygii" RELATED synonym [] -xref: GC_ID:1 -is_a: NCBITaxon:123365 ! Neoteleostei - -[Term] -id: NCBITaxon:123367 -name: Ctenosquamata -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:123366 ! Eurypterygia - -[Term] -id: NCBITaxon:123368 -name: Acanthomorphata -namespace: ncbi_taxonomy -synonym: "Acanthomorpha" RELATED synonym [] -xref: GC_ID:1 -is_a: NCBITaxon:123367 ! Ctenosquamata - -[Term] -id: NCBITaxon:123369 -name: Euacanthomorphacea -namespace: ncbi_taxonomy -synonym: "Euacanthomorpha" RELATED synonym [] -xref: GC_ID:1 -is_a: NCBITaxon:123368 ! Acanthomorphata - -[Term] -id: NCBITaxon:126287 -name: Didelphinae -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:9265 ! Didelphidae -property_value: has_rank NCBITaxon:subfamily - -[Term] -id: NCBITaxon:1294634 -name: Crocodylia -namespace: ncbi_taxonomy -synonym: "Crocodilia" RELATED synonym [] -synonym: "reptiles" RELATED in_part [] -synonym: "Reptilia" RELATED in_part [] -xref: GC_ID:1 -is_a: NCBITaxon:8492 ! Archosauria -property_value: has_rank NCBITaxon:order - -[Term] -id: NCBITaxon:1298654 -name: Longirostres -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:1294634 ! Crocodylia - -[Term] -id: NCBITaxon:1312402 -name: Xenacoelomorpha -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:33213 ! Bilateria -property_value: has_rank NCBITaxon:phylum - [Term] id: NCBITaxon:131567 name: cellular organisms -namespace: ncbi_taxonomy -synonym: "biota" RELATED synonym [] xref: GC_ID:1 is_a: NCBITaxon:1 ! root -[Term] -id: NCBITaxon:1329799 -name: Archelosauria -namespace: ncbi_taxonomy -synonym: "Archosauria-Testudines" RELATED synonym [] -synonym: "Testudines + Archosauria group" RELATED synonym [] -xref: GC_ID:1 -xref: PMID:22839753 -xref: PMID:25450099 -is_a: NCBITaxon:32561 ! Sauria - -[Term] -id: NCBITaxon:1329911 -name: Toxicofera -namespace: ncbi_taxonomy -xref: GC_ID:1 -xref: PMID:16286089 -xref: PMID:19281946 -xref: PMID:22982760 -is_a: NCBITaxon:1329912 ! Episquamata - -[Term] -id: NCBITaxon:1329912 -name: Episquamata -namespace: ncbi_taxonomy -xref: GC_ID:1 -xref: PMID:16286089 -xref: PMID:22982760 -is_a: NCBITaxon:1329950 ! Unidentata - -[Term] -id: NCBITaxon:1329950 -name: Unidentata -namespace: ncbi_taxonomy -xref: GC_ID:1 -xref: PMID:22982760 -is_a: NCBITaxon:1329961 ! Bifurcata - -[Term] -id: NCBITaxon:1329961 -name: Bifurcata -namespace: ncbi_taxonomy -synonym: "split-tongued squamates" EXACT genbank_common_name [] -xref: GC_ID:1 -xref: PMID:22982760 -is_a: NCBITaxon:8509 ! Squamata - -[Term] -id: NCBITaxon:133551 -name: Eleutherozoa -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:7586 ! Echinodermata - [Term] id: NCBITaxon:1338369 name: Dipnotetrapodomorpha -namespace: ncbi_taxonomy xref: GC_ID:1 is_a: NCBITaxon:8287 ! Sarcopterygii [Term] -id: NCBITaxon:13615 -name: Monodelphis -namespace: ncbi_taxonomy -synonym: "short-tailed opossums" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:126287 ! Didelphinae -property_value: has_rank NCBITaxon:genus - -[Term] -id: NCBITaxon:13616 -name: Monodelphis domestica -namespace: ncbi_taxonomy -synonym: "gray short-tailed opossum" EXACT genbank_common_name [] -synonym: "Monodelphis domesticus" RELATED misspelling [] +id: NCBITaxon:142796 +name: Eumycetozoa xref: GC_ID:1 -is_a: NCBITaxon:13615 ! Monodelphis -property_value: has_rank NCBITaxon:species +xref: PMID:11062127 +xref: PMID:9342353 +is_a: NCBITaxon:2605435 ! Evosea [Term] id: NCBITaxon:1437010 name: Boreoeutheria -namespace: ncbi_taxonomy -synonym: "Boreotheria" RELATED synonym [] xref: GC_ID:1 xref: PMID:11743200 xref: PMID:11791233 is_a: NCBITaxon:9347 ! Eutheria [Term] -id: NCBITaxon:147099 -name: Acoelomorpha -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:1312402 ! Xenacoelomorpha -property_value: has_rank NCBITaxon:subphylum - -[Term] -id: NCBITaxon:1476529 -name: Cyclostomata -namespace: ncbi_taxonomy -synonym: "Agnatha" RELATED synonym [] -synonym: "jawless vertebrates" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:7742 ! Vertebrata - -[Term] -id: NCBITaxon:1489340 -name: Elopocephalai -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:32443 ! Teleostei - -[Term] -id: NCBITaxon:1489341 -name: Osteoglossocephalai -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:32443 ! Teleostei - -[Term] -id: NCBITaxon:1489343 -name: Osteoglossocephala -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:1489341 ! Osteoglossocephalai - -[Term] -id: NCBITaxon:1489388 -name: Euteleosteomorpha -namespace: ncbi_taxonomy +id: NCBITaxon:1963758 +name: Myomorpha xref: GC_ID:1 -is_a: NCBITaxon:186625 ! Clupeocephala +is_a: NCBITaxon:9989 ! Rodentia [Term] -id: NCBITaxon:1489872 -name: Percomorphaceae -namespace: ncbi_taxonomy +id: NCBITaxon:207598 +name: Homininae xref: GC_ID:1 -is_a: NCBITaxon:123369 ! Euacanthomorphacea +is_a: NCBITaxon:9604 ! Hominidae [Term] -id: NCBITaxon:1489873 -name: Ophidiaria -namespace: ncbi_taxonomy -synonym: "Ophidiimorpharia" RELATED synonym [] +id: NCBITaxon:2605435 +name: Evosea xref: GC_ID:1 -is_a: NCBITaxon:1489872 ! Percomorphaceae +is_a: NCBITaxon:554915 ! Amoebozoa [Term] -id: NCBITaxon:1489908 -name: Ovalentaria -namespace: ncbi_taxonomy -synonym: "Stiassnyiformes" RELATED synonym [] +id: NCBITaxon:2759 +name: Eukaryota xref: GC_ID:1 -is_a: NCBITaxon:1489872 ! Percomorphaceae +xref: PMID:23020233 +xref: PMID:30257078 +is_a: NCBITaxon:131567 ! cellular organisms [Term] -id: NCBITaxon:1489913 -name: Atherinomorphae -namespace: ncbi_taxonomy -alt_id: NCBITaxon:32456 -synonym: "Atherinomorpha" RELATED synonym [] +id: NCBITaxon:314146 +name: Euarchontoglires xref: GC_ID:1 -is_a: NCBITaxon:1489908 ! Ovalentaria -property_value: has_rank NCBITaxon:superorder +xref: PMID:11214319 +xref: PMID:12082125 +xref: PMID:12878460 +xref: PMID:15522813 +is_a: NCBITaxon:1437010 ! Boreoeutheria [Term] -id: NCBITaxon:1489922 -name: Eupercaria -namespace: ncbi_taxonomy -synonym: "Percomorpharia" RELATED synonym [] +id: NCBITaxon:314147 +name: Glires xref: GC_ID:1 -is_a: NCBITaxon:1489872 ! Percomorphaceae +xref: PMID:11214319 +xref: PMID:12082125 +xref: PMID:15522813 +is_a: NCBITaxon:314146 ! Euarchontoglires [Term] -id: NCBITaxon:1547233 -name: Xenoturbellidae -namespace: ncbi_taxonomy +id: NCBITaxon:314293 +name: Simiiformes xref: GC_ID:1 -is_a: NCBITaxon:110814 ! Xenoturbellida -property_value: has_rank NCBITaxon:family +is_a: NCBITaxon:376913 ! Haplorrhini [Term] -id: NCBITaxon:1549675 -name: Galloanserae -namespace: ncbi_taxonomy -synonym: "ducks, geese, chickens, fowl, quail, currasows and allies" EXACT equivalent_name [] -synonym: "Galloanseri" RELATED synonym [] +id: NCBITaxon:314295 +name: Hominoidea xref: GC_ID:1 -is_a: NCBITaxon:8825 ! Neognathae +is_a: NCBITaxon:9526 ! Catarrhini [Term] -id: NCBITaxon:181400 -name: Bythitoidei -namespace: ncbi_taxonomy +id: NCBITaxon:32523 +name: Tetrapoda xref: GC_ID:1 -is_a: NCBITaxon:94929 ! Ophidiiformes -property_value: has_rank NCBITaxon:suborder +is_a: NCBITaxon:1338369 ! Dipnotetrapodomorpha [Term] -id: NCBITaxon:182222 -name: Muraeninae -namespace: ncbi_taxonomy +id: NCBITaxon:32524 +name: Amniota xref: GC_ID:1 -is_a: NCBITaxon:46660 ! Muraenidae -property_value: has_rank NCBITaxon:subfamily +is_a: NCBITaxon:32523 ! Tetrapoda [Term] -id: NCBITaxon:183770 -name: Enterogona -namespace: ncbi_taxonomy +id: NCBITaxon:32525 +name: Theria xref: GC_ID:1 -is_a: NCBITaxon:7713 ! Ascidiacea -property_value: has_rank NCBITaxon:order +is_a: NCBITaxon:40674 ! Mammalia [Term] -id: NCBITaxon:186623 -name: Actinopteri -namespace: ncbi_taxonomy +id: NCBITaxon:33154 +name: Opisthokonta xref: GC_ID:1 -is_a: NCBITaxon:7898 ! Actinopterygii -property_value: has_rank NCBITaxon:class +is_a: NCBITaxon:2759 ! Eukaryota [Term] -id: NCBITaxon:186624 -name: Elopocephala -namespace: ncbi_taxonomy +id: NCBITaxon:33208 +name: Metazoa xref: GC_ID:1 -is_a: NCBITaxon:1489340 ! Elopocephalai +is_a: NCBITaxon:33154 ! Opisthokonta [Term] -id: NCBITaxon:186625 -name: Clupeocephala -namespace: ncbi_taxonomy +id: NCBITaxon:33213 +name: Bilateria xref: GC_ID:1 -is_a: NCBITaxon:1489341 ! Osteoglossocephalai +is_a: NCBITaxon:6072 ! Eumetazoa [Term] -id: NCBITaxon:186626 -name: Otophysi -namespace: ncbi_taxonomy -synonym: "Otophysa" RELATED synonym [] +id: NCBITaxon:33317 +name: Protostomia xref: GC_ID:1 -is_a: NCBITaxon:32519 ! Ostariophysi +is_a: NCBITaxon:33213 ! Bilateria [Term] -id: NCBITaxon:186627 -name: Cypriniphysae -namespace: ncbi_taxonomy -synonym: "Cypriniphysi" RELATED synonym [] +id: NCBITaxon:33511 +name: Deuterostomia xref: GC_ID:1 -is_a: NCBITaxon:186626 ! Otophysi -property_value: has_rank NCBITaxon:superorder +is_a: NCBITaxon:33213 ! Bilateria [Term] -id: NCBITaxon:186634 -name: Otomorpha -namespace: ncbi_taxonomy -synonym: "Ostarioclupeomorpha" RELATED synonym [] -synonym: "Otocephala" RELATED synonym [] +id: NCBITaxon:337687 +name: Muroidea xref: GC_ID:1 -is_a: NCBITaxon:186625 ! Clupeocephala +xref: PMID:15019624 +xref: PMID:15371245 +is_a: NCBITaxon:1963758 ! Myomorpha [Term] -id: NCBITaxon:189497 -name: Echidna -namespace: ncbi_taxonomy +id: NCBITaxon:376913 +name: Haplorrhini xref: GC_ID:1 -is_a: NCBITaxon:182222 ! Muraeninae -property_value: has_rank NCBITaxon:genus +is_a: NCBITaxon:9443 ! Primates [Term] -id: NCBITaxon:1963758 -name: Myomorpha -namespace: ncbi_taxonomy -synonym: "Sciurognathi" RELATED in_part [] +id: NCBITaxon:39107 +name: Murinae xref: GC_ID:1 -is_a: NCBITaxon:9989 ! Rodentia -property_value: has_rank NCBITaxon:suborder +is_a: NCBITaxon:10066 ! Muridae [Term] -id: NCBITaxon:1963761 -name: Dipodoidea -namespace: ncbi_taxonomy +id: NCBITaxon:40674 +name: Mammalia xref: GC_ID:1 -is_a: NCBITaxon:1963758 ! Myomorpha -property_value: has_rank NCBITaxon:superfamily +is_a: NCBITaxon:32524 ! Amniota [Term] -id: NCBITaxon:197562 -name: Pancrustacea -namespace: ncbi_taxonomy +id: NCBITaxon:4751 +name: Fungi xref: GC_ID:1 -xref: PMID:10874751 -xref: PMID:11557979 -is_a: NCBITaxon:197563 ! Mandibulata +xref: PMID:11062127 +xref: PMID:12684019 +is_a: NCBITaxon:33154 ! Opisthokonta [Term] -id: NCBITaxon:197563 -name: Mandibulata -namespace: ncbi_taxonomy -synonym: "mandibulates" EXACT common_name [] +id: NCBITaxon:554915 +name: Amoebozoa xref: GC_ID:1 -xref: PMID:11557979 -xref: PMID:9727836 -is_a: NCBITaxon:6656 ! Arthropoda - -[Term] -id: NCBITaxon:2 -name: Bacteria -namespace: ncbi_taxonomy -synonym: "bacteria" RELATED blast_name [] -synonym: "eubacteria" EXACT genbank_common_name [] -synonym: "Monera" RELATED in_part [] -synonym: "Procaryotae" RELATED in_part [] -synonym: "Prokaryota" RELATED in_part [] -synonym: "Prokaryotae" RELATED in_part [] -synonym: "prokaryote" RELATED in_part [] -synonym: "prokaryotes" RELATED in_part [] -xref: GC_ID:11 -xref: PMID:10425795 -xref: PMID:10425796 -xref: PMID:10425797 -xref: PMID:10490293 -xref: PMID:10843050 -xref: PMID:10939651 -xref: PMID:10939673 -xref: PMID:10939677 -xref: PMID:11211268 -xref: PMID:11321083 -xref: PMID:11321113 -xref: PMID:11411719 -xref: PMID:11540071 -xref: PMID:11542017 -xref: PMID:11542087 -xref: PMID:11760965 -xref: PMID:12054223 -xref: PMID:2112744 -xref: PMID:270744 -xref: PMID:8123559 -xref: PMID:8590690 -xref: PMID:9103655 -xref: PMID:9336922 -is_a: NCBITaxon:131567 ! cellular organisms -property_value: has_rank NCBITaxon:superkingdom +xref: PMID:23020233 +xref: PMID:30257078 +is_a: NCBITaxon:2759 ! Eukaryota [Term] -id: NCBITaxon:2024747 -name: Dactyloidae -namespace: ncbi_taxonomy +id: NCBITaxon:6072 +name: Eumetazoa xref: GC_ID:1 -is_a: NCBITaxon:8511 ! Iguania -property_value: has_rank NCBITaxon:family +is_a: NCBITaxon:33208 ! Metazoa [Term] -id: NCBITaxon:207598 -name: Homininae -namespace: ncbi_taxonomy -synonym: "Homo/Pan/Gorilla group" RELATED synonym [] +id: NCBITaxon:6656 +name: Arthropoda xref: GC_ID:1 -is_a: NCBITaxon:9604 ! Hominidae -property_value: has_rank NCBITaxon:subfamily - -[Term] -id: NCBITaxon:2157 -name: Archaea -namespace: ncbi_taxonomy -synonym: "archaea" RELATED blast_name [] -synonym: "Archaebacteria" RELATED synonym [] -synonym: "Mendosicutes" RELATED synonym [] -synonym: "Metabacteria" RELATED synonym [] -synonym: "Monera" RELATED in_part [] -synonym: "Procaryotae" RELATED in_part [] -synonym: "Prokaryota" RELATED in_part [] -synonym: "Prokaryotae" RELATED in_part [] -synonym: "prokaryote" RELATED in_part [] -synonym: "prokaryotes" RELATED in_part [] -xref: GC_ID:11 -xref: PMID:10425795 -xref: PMID:10425796 -xref: PMID:10425797 -xref: PMID:10490293 -xref: PMID:10843050 -xref: PMID:10939651 -xref: PMID:10939673 -xref: PMID:10939677 -xref: PMID:11211268 -xref: PMID:11321083 -xref: PMID:11321113 -xref: PMID:11411719 -xref: PMID:11540071 -xref: PMID:11541975 -xref: PMID:11542064 -xref: PMID:11542149 -xref: PMID:11760965 -xref: PMID:12054223 -xref: PMID:2112744 -xref: PMID:25527841 -xref: PMID:270744 -xref: PMID:8123559 -xref: PMID:8590690 -xref: PMID:9103655 -xref: PMID:9336922 -is_a: NCBITaxon:131567 ! cellular organisms -property_value: has_rank NCBITaxon:superkingdom +is_a: NCBITaxon:88770 ! Panarthropoda [Term] -id: NCBITaxon:2172821 -name: Multicrustacea -namespace: ncbi_taxonomy +id: NCBITaxon:7711 +name: Chordata xref: GC_ID:1 -is_a: NCBITaxon:6657 ! Crustacea -property_value: has_rank NCBITaxon:superclass +is_a: NCBITaxon:33511 ! Deuterostomia [Term] -id: NCBITaxon:2182372 -name: Osphranter -namespace: ncbi_taxonomy +id: NCBITaxon:7742 +name: Vertebrata xref: GC_ID:1 -is_a: NCBITaxon:9307 ! Macropodidae -property_value: has_rank NCBITaxon:genus +is_a: NCBITaxon:89593 ! Craniata [Term] -id: NCBITaxon:262014 -name: Xenopus -namespace: ncbi_taxonomy -synonym: "Xenopus" EXACT scientific_name [] +id: NCBITaxon:7776 +name: Gnathostomata xref: GC_ID:1 -is_a: NCBITaxon:8353 ! Xenopus -property_value: has_rank NCBITaxon:subgenus +is_a: NCBITaxon:7742 ! Vertebrata [Term] -id: NCBITaxon:2759 -name: Eukaryota -namespace: ncbi_taxonomy -synonym: "Eucarya" RELATED synonym [] -synonym: "Eucaryotae" RELATED synonym [] -synonym: "eucaryotes" EXACT genbank_common_name [] -synonym: "Eukarya" RELATED synonym [] -synonym: "Eukaryotae" RELATED synonym [] -synonym: "eukaryotes" EXACT common_name [] -synonym: "eukaryotes" RELATED blast_name [] +id: NCBITaxon:8287 +name: Sarcopterygii xref: GC_ID:1 -xref: PMID:23020233 -is_a: NCBITaxon:131567 ! cellular organisms -property_value: has_rank NCBITaxon:superkingdom +is_a: NCBITaxon:117571 ! Euteleostomi [Term] -id: NCBITaxon:27592 -name: Bovinae -namespace: ncbi_taxonomy +id: NCBITaxon:862507 +name: Mus xref: GC_ID:1 -is_a: NCBITaxon:9895 ! Bovidae -property_value: has_rank NCBITaxon:subfamily +is_a: NCBITaxon:10088 ! Mus [Term] -id: NCBITaxon:28376 -name: Anolis -namespace: ncbi_taxonomy -alt_id: NCBITaxon:323564 -alt_id: NCBITaxon:75277 -synonym: "Norops" RELATED in_part [] +id: NCBITaxon:88770 +name: Panarthropoda xref: GC_ID:1 -is_a: NCBITaxon:2024747 ! Dactyloidae -property_value: has_rank NCBITaxon:genus +is_a: NCBITaxon:1206794 ! Ecdysozoa [Term] -id: NCBITaxon:28377 -name: Anolis carolinensis -namespace: ncbi_taxonomy -synonym: "Carolina anole" EXACT common_name [] -synonym: "green anole" EXACT genbank_common_name [] +id: NCBITaxon:89593 +name: Craniata xref: GC_ID:1 -is_a: NCBITaxon:28376 ! Anolis -property_value: has_rank NCBITaxon:species +is_a: NCBITaxon:7711 ! Chordata [Term] -id: NCBITaxon:28781 -name: Adrianichthyoidei -namespace: ncbi_taxonomy +id: NCBITaxon:9347 +name: Eutheria xref: GC_ID:1 -is_a: NCBITaxon:76071 ! Beloniformes -property_value: has_rank NCBITaxon:suborder +is_a: NCBITaxon:32525 ! Theria [Term] -id: NCBITaxon:30309 -name: Eptatretinae -namespace: ncbi_taxonomy +id: NCBITaxon:9443 +name: Primates xref: GC_ID:1 -is_a: NCBITaxon:7762 ! Myxinidae -property_value: has_rank NCBITaxon:subfamily +is_a: NCBITaxon:314146 ! Euarchontoglires [Term] -id: NCBITaxon:30319 -name: Pipoidea -namespace: ncbi_taxonomy +id: NCBITaxon:9526 +name: Catarrhini xref: GC_ID:1 -is_a: NCBITaxon:8342 ! Anura -property_value: has_rank NCBITaxon:superfamily +is_a: NCBITaxon:314293 ! Simiiformes [Term] -id: NCBITaxon:30458 -name: Strigiformes -namespace: ncbi_taxonomy -synonym: "owls" EXACT genbank_common_name [] +id: NCBITaxon:9604 +name: Hominidae xref: GC_ID:1 -is_a: NCBITaxon:8825 ! Neognathae -property_value: has_rank NCBITaxon:order +is_a: NCBITaxon:314295 ! Hominoidea [Term] -id: NCBITaxon:30577 -name: Erinaceinae -namespace: ncbi_taxonomy -synonym: "spiny hedgehogs" EXACT genbank_common_name [] +id: NCBITaxon:9605 +name: Homo xref: GC_ID:1 -is_a: NCBITaxon:9363 ! Erinaceidae -property_value: has_rank NCBITaxon:subfamily +is_a: NCBITaxon:207598 ! Homininae [Term] -id: NCBITaxon:30648 -name: Dipodidae -namespace: ncbi_taxonomy -synonym: "jerboas" EXACT genbank_common_name [] +id: NCBITaxon:9606 +name: Homo sapiens xref: GC_ID:1 -is_a: NCBITaxon:1963761 ! Dipodoidea -property_value: has_rank NCBITaxon:family +is_a: NCBITaxon:9605 ! Homo [Term] -id: NCBITaxon:30727 -name: Cyprinoidea -namespace: ncbi_taxonomy -synonym: "Cyprinoidei" RELATED synonym [] -xref: GC_ID:1 -is_a: NCBITaxon:7952 ! Cypriniformes -property_value: has_rank NCBITaxon:superfamily - -[Term] -id: NCBITaxon:31022 -name: Tetraodontiformes -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:1489922 ! Eupercaria -property_value: has_rank NCBITaxon:order - -[Term] -id: NCBITaxon:31028 -name: Tetraodontoidei -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:31022 ! Tetraodontiformes -property_value: has_rank NCBITaxon:suborder - -[Term] -id: NCBITaxon:31031 -name: Tetraodontidae -namespace: ncbi_taxonomy -synonym: "puffer fishes" EXACT common_name [] -synonym: "puffers" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:32517 ! Tetradontoidea -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:31032 -name: Takifugu -namespace: ncbi_taxonomy -synonym: "Fugu" RELATED synonym [] -xref: GC_ID:1 -is_a: NCBITaxon:31031 ! Tetraodontidae -property_value: has_rank NCBITaxon:genus - -[Term] -id: NCBITaxon:31033 -name: Takifugu rubripes -namespace: ncbi_taxonomy -synonym: "Fugu rubripes" RELATED genbank_synonym [] -synonym: "Sphaeroides rubripes" RELATED synonym [] -synonym: "Tetraodon rubripes" RELATED synonym [] -synonym: "tiger puffer" EXACT common_name [] -synonym: "torafugu" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:31032 ! Takifugu -property_value: has_rank NCBITaxon:species - -[Term] -id: NCBITaxon:31089 -name: Osteoglossomorpha -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:1489343 ! Osteoglossocephala - -[Term] -id: NCBITaxon:311790 -name: Afrotheria -namespace: ncbi_taxonomy -xref: GC_ID:1 -xref: PMID:11114173 -xref: PMID:11214319 -xref: PMID:12128031 -xref: PMID:12878460 -xref: PMID:15306319 -xref: PMID:9214502 -xref: PMID:9667998 -is_a: NCBITaxon:9347 ! Eutheria -property_value: has_rank NCBITaxon:superorder - -[Term] -id: NCBITaxon:314145 -name: Laurasiatheria -namespace: ncbi_taxonomy -xref: GC_ID:1 -xref: PMID:11214318 -xref: PMID:11214319 -xref: PMID:12878460 -is_a: NCBITaxon:1437010 ! Boreoeutheria -property_value: has_rank NCBITaxon:superorder - -[Term] -id: NCBITaxon:314146 -name: Euarchontoglires -namespace: ncbi_taxonomy -xref: GC_ID:1 -xref: PMID:11214319 -xref: PMID:12082125 -xref: PMID:12878460 -xref: PMID:15522813 -is_a: NCBITaxon:1437010 ! Boreoeutheria -property_value: has_rank NCBITaxon:superorder - -[Term] -id: NCBITaxon:314147 -name: Glires -namespace: ncbi_taxonomy -synonym: "Rodents and rabbits" EXACT genbank_common_name [] -xref: GC_ID:1 -xref: PMID:11214319 -xref: PMID:12082125 -xref: PMID:15522813 -is_a: NCBITaxon:314146 ! Euarchontoglires - -[Term] -id: NCBITaxon:314293 -name: Simiiformes -namespace: ncbi_taxonomy -synonym: "Anthropoidea" RELATED synonym [] -xref: GC_ID:1 -is_a: NCBITaxon:376913 ! Haplorrhini -property_value: has_rank NCBITaxon:infraorder - -[Term] -id: NCBITaxon:314294 -name: Cercopithecoidea -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:9526 ! Catarrhini -property_value: has_rank NCBITaxon:superfamily - -[Term] -id: NCBITaxon:314295 -name: Hominoidea -namespace: ncbi_taxonomy -synonym: "ape" EXACT common_name [] -synonym: "apes" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:9526 ! Catarrhini -property_value: has_rank NCBITaxon:superfamily - -[Term] -id: NCBITaxon:32341 -name: Sophophora -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:7215 ! Drosophila -property_value: has_rank NCBITaxon:subgenus - -[Term] -id: NCBITaxon:32346 -name: melanogaster group -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:32341 ! Sophophora -property_value: has_rank http://purl.obolibrary.org/obo/NCBITaxon_species_group - -[Term] -id: NCBITaxon:32351 -name: melanogaster subgroup -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:32346 ! melanogaster group -property_value: has_rank http://purl.obolibrary.org/obo/NCBITaxon_species_subgroup - -[Term] -id: NCBITaxon:32443 -name: Teleostei -namespace: ncbi_taxonomy -synonym: "teleost fishes" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:41665 ! Neopterygii -property_value: has_rank NCBITaxon:infraclass - -[Term] -id: NCBITaxon:32517 -name: Tetradontoidea -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:31028 ! Tetraodontoidei -property_value: has_rank NCBITaxon:superfamily - -[Term] -id: NCBITaxon:32519 -name: Ostariophysi -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:186634 ! Otomorpha - -[Term] -id: NCBITaxon:32521 -name: Elopomorpha -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:186624 ! Elopocephala - -[Term] -id: NCBITaxon:32523 -name: Tetrapoda -namespace: ncbi_taxonomy -synonym: "tetrapods" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:1338369 ! Dipnotetrapodomorpha - -[Term] -id: NCBITaxon:32524 -name: Amniota -namespace: ncbi_taxonomy -synonym: "amniotes" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:32523 ! Tetrapoda - -[Term] -id: NCBITaxon:32525 -name: Theria -namespace: ncbi_taxonomy -synonym: "Theria" EXACT scientific_name [] -xref: GC_ID:1 -is_a: NCBITaxon:40674 ! Mammalia - -[Term] -id: NCBITaxon:32561 -name: Sauria -namespace: ncbi_taxonomy -synonym: "Diapsida" RELATED synonym [] -synonym: "diapsids" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:8457 ! Sauropsida - -[Term] -id: NCBITaxon:33154 -name: Opisthokonta -namespace: ncbi_taxonomy -synonym: "Fungi/Metazoa group" RELATED synonym [] -synonym: "opisthokonts" RELATED synonym [] -xref: GC_ID:1 -is_a: NCBITaxon:2759 ! Eukaryota - -[Term] -id: NCBITaxon:33208 -name: Metazoa -namespace: ncbi_taxonomy -synonym: "Animalia" RELATED synonym [] -synonym: "animals" RELATED blast_name [] -synonym: "metazoans" EXACT genbank_common_name [] -synonym: "multicellular animals" EXACT common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:33154 ! Opisthokonta -property_value: has_rank NCBITaxon:kingdom - -[Term] -id: NCBITaxon:33213 -name: Bilateria -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:6072 ! Eumetazoa - -[Term] -id: NCBITaxon:33317 -name: Protostomia -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:33213 ! Bilateria - -[Term] -id: NCBITaxon:33340 -name: Neoptera -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:7496 ! Pterygota -property_value: has_rank NCBITaxon:infraclass - -[Term] -id: NCBITaxon:33392 -name: Holometabola -namespace: ncbi_taxonomy -synonym: "Endopterygota" RELATED synonym [] -xref: GC_ID:1 -is_a: NCBITaxon:33340 ! Neoptera -property_value: has_rank NCBITaxon:cohort - -[Term] -id: NCBITaxon:33511 -name: Deuterostomia -namespace: ncbi_taxonomy -synonym: "deuterostomes" EXACT common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:33213 ! Bilateria - -[Term] -id: NCBITaxon:33553 -name: Sciuromorpha -namespace: ncbi_taxonomy -alt_id: NCBITaxon:10024 -alt_id: NCBITaxon:9990 -synonym: "Sciurognathi" RELATED in_part [] -xref: GC_ID:1 -is_a: NCBITaxon:9989 ! Rodentia -property_value: has_rank NCBITaxon:suborder - -[Term] -id: NCBITaxon:33554 -name: Carnivora -namespace: ncbi_taxonomy -synonym: "carnivores" EXACT genbank_common_name [] -synonym: "carnivores" RELATED blast_name [] -xref: GC_ID:1 -is_a: NCBITaxon:314145 ! Laurasiatheria -property_value: has_rank NCBITaxon:order - -[Term] -id: NCBITaxon:337687 -name: Muroidea -namespace: ncbi_taxonomy -xref: GC_ID:1 -xref: PMID:15019624 -xref: PMID:15371245 -is_a: NCBITaxon:1963758 ! Myomorpha - -[Term] -id: NCBITaxon:34989 -name: Colubroidea -namespace: ncbi_taxonomy -synonym: "Xenophidia" RELATED synonym [] -xref: GC_ID:1 -is_a: NCBITaxon:8570 ! Serpentes -property_value: has_rank NCBITaxon:superfamily - -[Term] -id: NCBITaxon:35497 -name: Suina -namespace: ncbi_taxonomy -synonym: "Artiodactyla" RELATED in_part [] -synonym: "Suiformes" RELATED in_part [] -xref: GC_ID:1 -is_a: NCBITaxon:91561 ! Cetartiodactyla -property_value: has_rank NCBITaxon:infraorder - -[Term] -id: NCBITaxon:35500 -name: Pecora -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:9845 ! Ruminantia -property_value: has_rank NCBITaxon:infraorder - -[Term] -id: NCBITaxon:35737 -name: Dipodinae -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:30648 ! Dipodidae -property_value: has_rank NCBITaxon:subfamily - -[Term] -id: NCBITaxon:37512 -name: Ceriantharia -namespace: ncbi_taxonomy -synonym: "tube anemones" RELATED blast_name [] -synonym: "tube-dwelling anemones" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:6102 ! Hexacorallia -property_value: has_rank NCBITaxon:order - -[Term] -id: NCBITaxon:37567 -name: Ditrysia -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:41197 ! Heteroneura - -[Term] -id: NCBITaxon:37572 -name: Papilionoidea -namespace: ncbi_taxonomy -synonym: "butterflies" EXACT genbank_common_name [] -synonym: "butterflies" RELATED blast_name [] -xref: GC_ID:1 -is_a: NCBITaxon:104431 ! Obtectomera -property_value: has_rank NCBITaxon:superfamily - -[Term] -id: NCBITaxon:376912 -name: Tarsiiformes -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:376913 ! Haplorrhini -property_value: has_rank NCBITaxon:infraorder - -[Term] -id: NCBITaxon:376913 -name: Haplorrhini -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:9443 ! Primates -property_value: has_rank NCBITaxon:suborder - -[Term] -id: NCBITaxon:378855 -name: Atelidae -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:9479 ! Platyrrhini -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:379583 -name: Feliformia -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:33554 ! Carnivora -property_value: has_rank NCBITaxon:suborder - -[Term] -id: NCBITaxon:379584 -name: Caniformia -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:33554 ! Carnivora -property_value: has_rank NCBITaxon:suborder - -[Term] -id: NCBITaxon:38066 -name: Alouattinae -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:378855 ! Atelidae -property_value: has_rank NCBITaxon:subfamily - -[Term] -id: NCBITaxon:38605 -name: Didelphimorphia -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:9263 ! Metatheria -property_value: has_rank NCBITaxon:order - -[Term] -id: NCBITaxon:38609 -name: Diprotodontia -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:9263 ! Metatheria -property_value: has_rank NCBITaxon:order - -[Term] -id: NCBITaxon:39107 -name: Murinae -namespace: ncbi_taxonomy -alt_id: NCBITaxon:109679 -xref: GC_ID:1 -is_a: NCBITaxon:10066 ! Muridae -property_value: has_rank NCBITaxon:subfamily - -[Term] -id: NCBITaxon:39820 -name: Nereididae -namespace: ncbi_taxonomy -synonym: "Nereidae" RELATED synonym [] -synonym: "sandworms" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:6348 ! Phyllodocida -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:40150 -name: Monodon -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:9747 ! Monodontidae -property_value: has_rank NCBITaxon:genus - -[Term] -id: NCBITaxon:40151 -name: Monodon monoceros -namespace: ncbi_taxonomy -synonym: "narwhal" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:40150 ! Monodon -property_value: has_rank NCBITaxon:species - -[Term] -id: NCBITaxon:40674 -name: Mammalia -namespace: ncbi_taxonomy -synonym: "mammals" EXACT genbank_common_name [] -synonym: "mammals" RELATED blast_name [] -xref: GC_ID:1 -is_a: NCBITaxon:32524 ! Amniota -property_value: has_rank NCBITaxon:class - -[Term] -id: NCBITaxon:41191 -name: Glossata -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:7088 ! Lepidoptera -property_value: has_rank NCBITaxon:suborder - -[Term] -id: NCBITaxon:41196 -name: Neolepidoptera -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:41191 ! Glossata -property_value: has_rank NCBITaxon:infraorder - -[Term] -id: NCBITaxon:41197 -name: Heteroneura -namespace: ncbi_taxonomy -alt_id: NCBITaxon:37583 -xref: GC_ID:1 -is_a: NCBITaxon:41196 ! Neolepidoptera -property_value: has_rank NCBITaxon:parvorder - -[Term] -id: NCBITaxon:41324 -name: Siboglinidae -namespace: ncbi_taxonomy -alt_id: NCBITaxon:167797 -alt_id: NCBITaxon:27906 -alt_id: NCBITaxon:29174 -alt_id: NCBITaxon:41329 -alt_id: NCBITaxon:54122 -alt_id: NCBITaxon:55674 -alt_id: NCBITaxon:55678 -alt_id: NCBITaxon:6422 -synonym: "Frenulata" RELATED synonym [] -synonym: "Lamellibrachiidae" RELATED synonym [] -synonym: "Obturata" RELATED synonym [] -synonym: "Oligobrachiidae" RELATED synonym [] -synonym: "Perviata" RELATED synonym [] -synonym: "Pogonophora" RELATED synonym [] -synonym: "pogonophores" EXACT common_name [] -synonym: "Polybrachiidae" RELATED synonym [] -synonym: "Sclerolinidae" RELATED synonym [] -synonym: "tube worms" RELATED blast_name [] -synonym: "Vestimentifera" RELATED synonym [] -synonym: "vestimentiferans" EXACT common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:6362 ! Sabellida -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:41665 -name: Neopterygii -namespace: ncbi_taxonomy -synonym: "Neopterygi" RELATED synonym [] -xref: GC_ID:1 -is_a: NCBITaxon:186623 ! Actinopteri -property_value: has_rank NCBITaxon:subclass - -[Term] -id: NCBITaxon:41666 -name: Batrachia -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:8292 ! Amphibia -property_value: has_rank NCBITaxon:superorder - -[Term] -id: NCBITaxon:41712 -name: Osteoglossiformes -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:31089 ! Osteoglossomorpha -property_value: has_rank NCBITaxon:order - -[Term] -id: NCBITaxon:43453 -name: Caecilia -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:8446 ! Caeciliidae -property_value: has_rank NCBITaxon:genus - -[Term] -id: NCBITaxon:436486 -name: Dinosauria -namespace: ncbi_taxonomy -synonym: "dinosaur" EXACT common_name [] -synonym: "dinosaurs" EXACT common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:8492 ! Archosauria - -[Term] -id: NCBITaxon:436489 -name: Saurischia -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:436486 ! Dinosauria - -[Term] -id: NCBITaxon:436491 -name: Theropoda -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:436489 ! Saurischia - -[Term] -id: NCBITaxon:436492 -name: Coelurosauria -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:436491 ! Theropoda - -[Term] -id: NCBITaxon:43733 -name: Muscomorpha -namespace: ncbi_taxonomy -alt_id: NCBITaxon:43732 -synonym: "Asilomorpha" RELATED synonym [] -xref: GC_ID:1 -is_a: NCBITaxon:7203 ! Brachycera -property_value: has_rank NCBITaxon:infraorder - -[Term] -id: NCBITaxon:43738 -name: Schizophora -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:480117 ! Cyclorrhapha - -[Term] -id: NCBITaxon:43741 -name: Acalyptratae -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:43738 ! Schizophora - -[Term] -id: NCBITaxon:43746 -name: Ephydroidea -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:43741 ! Acalyptratae -property_value: has_rank NCBITaxon:superfamily - -[Term] -id: NCBITaxon:43845 -name: Drosophilinae -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:7214 ! Drosophilidae -property_value: has_rank NCBITaxon:subfamily - -[Term] -id: NCBITaxon:46660 -name: Muraenidae -namespace: ncbi_taxonomy -synonym: "moray eels" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:7933 ! Anguilliformes -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:46877 -name: Drosophilini -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:43845 ! Drosophilinae -property_value: has_rank NCBITaxon:tribe - -[Term] -id: NCBITaxon:47144 -name: Tetraodon -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:31031 ! Tetraodontidae -property_value: has_rank NCBITaxon:genus - -[Term] -id: NCBITaxon:47757 -name: Adrianichthyidae -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:28781 ! Adrianichthyoidei -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:480117 -name: Cyclorrhapha -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:480118 ! Eremoneura - -[Term] -id: NCBITaxon:480118 -name: Eremoneura -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:43733 ! Muscomorpha - -[Term] -id: NCBITaxon:48867 -name: Jaculus -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:35737 ! Dipodinae -property_value: has_rank NCBITaxon:genus - -[Term] -id: NCBITaxon:50557 -name: Insecta -namespace: ncbi_taxonomy -synonym: "true insects" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:6960 ! Hexapoda -property_value: has_rank NCBITaxon:class - -[Term] -id: NCBITaxon:51337 -name: Jaculus jaculus -namespace: ncbi_taxonomy -synonym: "lesser Egyptian jerboa" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:48867 ! Jaculus -property_value: has_rank NCBITaxon:species - -[Term] -id: NCBITaxon:51985 -name: Ctenostomatida -namespace: ncbi_taxonomy -synonym: "Ctenostomata" RELATED synonym [] -xref: GC_ID:1 -is_a: NCBITaxon:10206 ! Gymnolaemata -property_value: has_rank NCBITaxon:order - -[Term] -id: NCBITaxon:55879 -name: Rhabditoidea -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:6236 ! Rhabditida -property_value: has_rank NCBITaxon:superfamily - -[Term] -id: NCBITaxon:55885 -name: Peloderinae -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:6243 ! Rhabditidae -property_value: has_rank NCBITaxon:subfamily - -[Term] -id: NCBITaxon:569420 -name: Paludicellidae -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:51985 ! Ctenostomatida -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:569421 -name: Paludicella -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:569420 ! Paludicellidae -property_value: has_rank NCBITaxon:genus - -[Term] -id: NCBITaxon:569425 -name: Paludicella articulata -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:569421 ! Paludicella -property_value: has_rank NCBITaxon:species - -[Term] -id: NCBITaxon:6040 -name: Porifera -namespace: ncbi_taxonomy -synonym: "Parazoa" RELATED synonym [] -synonym: "sponges" EXACT genbank_common_name [] -synonym: "sponges" RELATED blast_name [] -xref: GC_ID:1 -is_a: NCBITaxon:33208 ! Metazoa -property_value: has_rank NCBITaxon:phylum - -[Term] -id: NCBITaxon:6072 -name: Eumetazoa -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:33208 ! Metazoa - -[Term] -id: NCBITaxon:6073 -name: Cnidaria -namespace: ncbi_taxonomy -synonym: "cnidarians" EXACT genbank_common_name [] -synonym: "cnidarians" RELATED blast_name [] -synonym: "Coelenterata" RELATED in_part [] -synonym: "coelenterates" EXACT common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:6072 ! Eumetazoa -property_value: has_rank NCBITaxon:phylum - -[Term] -id: NCBITaxon:607660 -name: Ponginae -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:9604 ! Hominidae -property_value: has_rank NCBITaxon:subfamily - -[Term] -id: NCBITaxon:6101 -name: Anthozoa -namespace: ncbi_taxonomy -synonym: "anthozoans" EXACT genbank_common_name [] -synonym: "anthozoans" RELATED blast_name [] -xref: GC_ID:1 -is_a: NCBITaxon:6073 ! Cnidaria -property_value: has_rank NCBITaxon:class - -[Term] -id: NCBITaxon:6102 -name: Hexacorallia -namespace: ncbi_taxonomy -alt_id: NCBITaxon:44167 -synonym: "Zoantharia" RELATED synonym [] -xref: GC_ID:1 -is_a: NCBITaxon:6101 ! Anthozoa -property_value: has_rank NCBITaxon:subclass - -[Term] -id: NCBITaxon:6157 -name: Platyhelminthes -namespace: ncbi_taxonomy -synonym: "flatworm" EXACT common_name [] -synonym: "flatworms" EXACT genbank_common_name [] -synonym: "flatworms" RELATED blast_name [] -xref: GC_ID:1 -is_a: NCBITaxon:33213 ! Bilateria -property_value: has_rank NCBITaxon:phylum - -[Term] -id: NCBITaxon:6178 -name: Trematoda -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:6157 ! Platyhelminthes -property_value: has_rank NCBITaxon:class - -[Term] -id: NCBITaxon:6199 -name: Cestoda -namespace: ncbi_taxonomy -synonym: "tapeworms" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:6157 ! Platyhelminthes -property_value: has_rank NCBITaxon:class - -[Term] -id: NCBITaxon:6200 -name: Eucestoda -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:6199 ! Cestoda -property_value: has_rank NCBITaxon:subclass - -[Term] -id: NCBITaxon:6201 -name: Cyclophyllidea -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:6200 ! Eucestoda -property_value: has_rank NCBITaxon:order - -[Term] -id: NCBITaxon:6208 -name: Taeniidae -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:6201 ! Cyclophyllidea -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:6209 -name: Echinococcus -namespace: ncbi_taxonomy -xref: GC_ID:1 -xref: PMID:12377596 -xref: PMID:12964823 -xref: PMID:16352465 -xref: PMID:17156584 -xref: PMID:18180956 -xref: PMID:18338180 -is_a: NCBITaxon:6208 ! Taeniidae -property_value: has_rank NCBITaxon:genus - -[Term] -id: NCBITaxon:6211 -name: Echinococcus multilocularis -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:6209 ! Echinococcus -property_value: has_rank NCBITaxon:species - -[Term] -id: NCBITaxon:6217 -name: Nemertea -namespace: ncbi_taxonomy -synonym: "bootlace worms" EXACT common_name [] -synonym: "nemertines" EXACT common_name [] -synonym: "Nemertini" RELATED synonym [] -synonym: "ribbon worms" EXACT genbank_common_name [] -synonym: "ribbon worms" RELATED blast_name [] -xref: GC_ID:1 -is_a: NCBITaxon:1206795 ! Lophotrochozoa -property_value: has_rank NCBITaxon:phylum - -[Term] -id: NCBITaxon:6231 -name: Nematoda -namespace: ncbi_taxonomy -synonym: "Nemata" RELATED synonym [] -synonym: "nematode" EXACT common_name [] -synonym: "nematodes" EXACT common_name [] -synonym: "nematodes" RELATED blast_name [] -synonym: "roundworm" EXACT common_name [] -synonym: "roundworms" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:1206794 ! Ecdysozoa -property_value: has_rank NCBITaxon:phylum - -[Term] -id: NCBITaxon:6236 -name: Rhabditida -namespace: ncbi_taxonomy -alt_id: NCBITaxon:33251 -xref: GC_ID:1 -is_a: NCBITaxon:119089 ! Chromadorea -property_value: has_rank NCBITaxon:order - -[Term] -id: NCBITaxon:6237 -name: Caenorhabditis -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:55885 ! Peloderinae -property_value: has_rank NCBITaxon:genus - -[Term] -id: NCBITaxon:6239 -name: Caenorhabditis elegans -namespace: ncbi_taxonomy -synonym: "Rhabditis elegans" RELATED synonym [] -synonym: "roundworm" EXACT common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:6237 ! Caenorhabditis -property_value: has_rank NCBITaxon:species - -[Term] -id: NCBITaxon:6243 -name: Rhabditidae -namespace: ncbi_taxonomy -alt_id: NCBITaxon:54603 -xref: GC_ID:1 -is_a: NCBITaxon:55879 ! Rhabditoidea -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:6340 -name: Annelida -namespace: ncbi_taxonomy -synonym: "annelid worms" EXACT genbank_common_name [] -synonym: "segmented worms" RELATED blast_name [] -xref: GC_ID:1 -is_a: NCBITaxon:1206795 ! Lophotrochozoa -property_value: has_rank NCBITaxon:phylum - -[Term] -id: NCBITaxon:6341 -name: Polychaeta -namespace: ncbi_taxonomy -synonym: "polychaetes" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:6340 ! Annelida -property_value: has_rank NCBITaxon:class - -[Term] -id: NCBITaxon:6348 -name: Phyllodocida -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:105390 ! Aciculata -property_value: has_rank NCBITaxon:order - -[Term] -id: NCBITaxon:6358 -name: Platynereis -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:39820 ! Nereididae -property_value: has_rank NCBITaxon:genus - -[Term] -id: NCBITaxon:6362 -name: Sabellida -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:105391 ! Canalipalpata -property_value: has_rank NCBITaxon:order - -[Term] -id: NCBITaxon:6425 -name: Riftia -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:41324 ! Siboglinidae -property_value: has_rank NCBITaxon:genus - -[Term] -id: NCBITaxon:6447 -name: Mollusca -namespace: ncbi_taxonomy -synonym: "molluscs" EXACT common_name [] -synonym: "molluscs" RELATED blast_name [] -synonym: "mollusks" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:1206795 ! Lophotrochozoa -property_value: has_rank NCBITaxon:phylum - -[Term] -id: NCBITaxon:6448 -name: Gastropoda -namespace: ncbi_taxonomy -synonym: "gastropods" EXACT genbank_common_name [] -synonym: "gastropods" RELATED blast_name [] -xref: GC_ID:1 -is_a: NCBITaxon:6447 ! Mollusca -property_value: has_rank NCBITaxon:class - -[Term] -id: NCBITaxon:6544 -name: Bivalvia -namespace: ncbi_taxonomy -synonym: "bivalves" EXACT genbank_common_name [] -synonym: "bivalves" RELATED blast_name [] -synonym: "Lamellibranchiata" RELATED synonym [] -synonym: "Pelecypoda" RELATED synonym [] -xref: GC_ID:1 -is_a: NCBITaxon:6447 ! Mollusca -property_value: has_rank NCBITaxon:class - -[Term] -id: NCBITaxon:6656 -name: Arthropoda -namespace: ncbi_taxonomy -synonym: "arthropods" EXACT genbank_common_name [] -synonym: "arthropods" RELATED blast_name [] -xref: GC_ID:1 -is_a: NCBITaxon:88770 ! Panarthropoda -property_value: has_rank NCBITaxon:phylum - -[Term] -id: NCBITaxon:6657 -name: Crustacea -namespace: ncbi_taxonomy -synonym: "crustaceans" EXACT genbank_common_name [] -synonym: "crustaceans" RELATED blast_name [] -xref: GC_ID:1 -is_a: NCBITaxon:197562 ! Pancrustacea -property_value: has_rank NCBITaxon:subphylum - -[Term] -id: NCBITaxon:6830 -name: Copepoda -namespace: ncbi_taxonomy -synonym: "copepods" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:72037 ! Hexanauplia -property_value: has_rank NCBITaxon:subclass - -[Term] -id: NCBITaxon:6843 -name: Chelicerata -namespace: ncbi_taxonomy -synonym: "chelicerates" EXACT common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:6656 ! Arthropoda -property_value: has_rank NCBITaxon:subphylum - -[Term] -id: NCBITaxon:6854 -name: Arachnida -namespace: ncbi_taxonomy -synonym: "arachnids" EXACT genbank_common_name [] -synonym: "arachnids" RELATED blast_name [] -xref: GC_ID:1 -is_a: NCBITaxon:6843 ! Chelicerata -property_value: has_rank NCBITaxon:class - -[Term] -id: NCBITaxon:6960 -name: Hexapoda -namespace: ncbi_taxonomy -synonym: "Atelocerata" RELATED in_part [] -synonym: "insects" EXACT genbank_common_name [] -synonym: "insects" RELATED blast_name [] -synonym: "Tracheata" RELATED in_part [] -synonym: "Uniramia" RELATED in_part [] -xref: GC_ID:1 -is_a: NCBITaxon:197562 ! Pancrustacea -property_value: has_rank NCBITaxon:subphylum - -[Term] -id: NCBITaxon:7088 -name: Lepidoptera -namespace: ncbi_taxonomy -synonym: "butterflies and moths" EXACT genbank_common_name [] -synonym: "moths" EXACT common_name [] -synonym: "moths" RELATED blast_name [] -xref: GC_ID:1 -is_a: NCBITaxon:85604 ! Amphiesmenoptera -property_value: has_rank NCBITaxon:order - -[Term] -id: NCBITaxon:7147 -name: Diptera -namespace: ncbi_taxonomy -synonym: "flies" EXACT genbank_common_name [] -synonym: "flies" RELATED blast_name [] -xref: GC_ID:1 -is_a: NCBITaxon:33392 ! Holometabola -property_value: has_rank NCBITaxon:order - -[Term] -id: NCBITaxon:7203 -name: Brachycera -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:7147 ! Diptera -property_value: has_rank NCBITaxon:suborder - -[Term] -id: NCBITaxon:72037 -name: Hexanauplia -namespace: ncbi_taxonomy -alt_id: NCBITaxon:2172815 -xref: GC_ID:1 -is_a: NCBITaxon:2172821 ! Multicrustacea -property_value: has_rank NCBITaxon:class - -[Term] -id: NCBITaxon:7214 -name: Drosophilidae -namespace: ncbi_taxonomy -synonym: "pomace flies" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:43746 ! Ephydroidea -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:7215 -name: Drosophila -namespace: ncbi_taxonomy -alt_id: NCBITaxon:7326 -synonym: "Drosophila" EXACT scientific_name [] -synonym: "fruit flies" EXACT genbank_common_name [] -synonym: "fruit fly" EXACT common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:46877 ! Drosophilini -property_value: has_rank NCBITaxon:genus - -[Term] -id: NCBITaxon:7227 -name: Drosophila melanogaster -namespace: ncbi_taxonomy -synonym: "Drosophila melangaster" RELATED misspelling [] -synonym: "fruit fly" EXACT genbank_common_name [] -synonym: "Sophophora melanogaster" RELATED synonym [] -xref: GC_ID:1 -is_a: NCBITaxon:32351 ! melanogaster subgroup -property_value: has_rank NCBITaxon:species - -[Term] -id: NCBITaxon:7496 -name: Pterygota -namespace: ncbi_taxonomy -synonym: "Pterygota" EXACT scientific_name [] -synonym: "winged insects" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:85512 ! Dicondylia -property_value: has_rank NCBITaxon:subclass - -[Term] -id: NCBITaxon:7586 -name: Echinodermata -namespace: ncbi_taxonomy -synonym: "echinoderms" EXACT genbank_common_name [] -synonym: "echinoderms" RELATED blast_name [] -xref: GC_ID:1 -is_a: NCBITaxon:33511 ! Deuterostomia -property_value: has_rank NCBITaxon:phylum - -[Term] -id: NCBITaxon:7587 -name: Asterozoa -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:133551 ! Eleutherozoa -property_value: has_rank NCBITaxon:superclass - -[Term] -id: NCBITaxon:7588 -name: Asteroidea -namespace: ncbi_taxonomy -synonym: "sea stars" EXACT common_name [] -synonym: "starfish" EXACT common_name [] -synonym: "starfish" RELATED blast_name [] -synonym: "starfishes" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:7587 ! Asterozoa -property_value: has_rank NCBITaxon:class - -[Term] -id: NCBITaxon:76071 -name: Beloniformes -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:1489913 ! Atherinomorphae -property_value: has_rank NCBITaxon:order - -[Term] -id: NCBITaxon:7624 -name: Echinozoa -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:133551 ! Eleutherozoa -property_value: has_rank NCBITaxon:superclass - -[Term] -id: NCBITaxon:7625 -name: Echinoidea -namespace: ncbi_taxonomy -synonym: "sea urchins" EXACT genbank_common_name [] -synonym: "sea urchins" RELATED blast_name [] -xref: GC_ID:1 -is_a: NCBITaxon:7624 ! Echinozoa -property_value: has_rank NCBITaxon:class - -[Term] -id: NCBITaxon:7711 -name: Chordata -namespace: ncbi_taxonomy -synonym: "chordates" EXACT genbank_common_name [] -synonym: "chordates" RELATED blast_name [] -xref: GC_ID:1 -is_a: NCBITaxon:33511 ! Deuterostomia -property_value: has_rank NCBITaxon:phylum - -[Term] -id: NCBITaxon:7712 -name: Tunicata -namespace: ncbi_taxonomy -synonym: "tunicates" EXACT genbank_common_name [] -synonym: "tunicates" RELATED blast_name [] -synonym: "Urochordata" RELATED synonym [] -xref: GC_ID:1 -is_a: NCBITaxon:7711 ! Chordata -property_value: has_rank NCBITaxon:subphylum - -[Term] -id: NCBITaxon:7713 -name: Ascidiacea -namespace: ncbi_taxonomy -synonym: "sea squirts" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:7712 ! Tunicata -property_value: has_rank NCBITaxon:class - -[Term] -id: NCBITaxon:7716 -name: Phlebobranchia -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:183770 ! Enterogona -property_value: has_rank NCBITaxon:suborder - -[Term] -id: NCBITaxon:7717 -name: Cionidae -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:7716 ! Phlebobranchia -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:7718 -name: Ciona -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:7717 ! Cionidae -property_value: has_rank NCBITaxon:genus - -[Term] -id: NCBITaxon:7735 -name: Cephalochordata -namespace: ncbi_taxonomy -synonym: "lancelets" RELATED blast_name [] -xref: GC_ID:1 -is_a: NCBITaxon:7711 ! Chordata -property_value: has_rank NCBITaxon:subphylum - -[Term] -id: NCBITaxon:7736 -name: Branchiostomidae -namespace: ncbi_taxonomy -synonym: "amphioxi" EXACT common_name [] -synonym: "amphioxius" EXACT common_name [] -synonym: "Branchiostomatidae" RELATED synonym [] -synonym: "lancelets" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:7735 ! Cephalochordata -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:7737 -name: Branchiostoma -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:7736 ! Branchiostomidae -property_value: has_rank NCBITaxon:genus - -[Term] -id: NCBITaxon:7742 -name: Vertebrata -namespace: ncbi_taxonomy -synonym: "Vertebrata" EXACT scientific_name [] -synonym: "vertebrates" EXACT genbank_common_name [] -synonym: "vertebrates" RELATED blast_name [] -xref: GC_ID:1 -is_a: NCBITaxon:89593 ! Craniata - -[Term] -id: NCBITaxon:7745 -name: Petromyzontiformes -namespace: ncbi_taxonomy -synonym: "lampreys" RELATED blast_name [] -synonym: "Petromyzoniformes" RELATED synonym [] -xref: GC_ID:1 -is_a: NCBITaxon:117569 ! Hyperoartia -property_value: has_rank NCBITaxon:order - -[Term] -id: NCBITaxon:7746 -name: Petromyzontidae -namespace: ncbi_taxonomy -synonym: "lampreys" EXACT genbank_common_name [] -synonym: "Petromyzonidae" RELATED misspelling [] -xref: GC_ID:1 -is_a: NCBITaxon:7745 ! Petromyzontiformes -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:7761 -name: Myxiniformes -namespace: ncbi_taxonomy -synonym: "hagfishes" RELATED blast_name [] -synonym: "Myxinoidea" RELATED synonym [] -xref: GC_ID:1 -is_a: NCBITaxon:117565 ! Hyperotreti -property_value: has_rank NCBITaxon:order - -[Term] -id: NCBITaxon:7762 -name: Myxinidae -namespace: ncbi_taxonomy -synonym: "hagfishes" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:7761 ! Myxiniformes -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:7763 -name: Eptatretus -namespace: ncbi_taxonomy -alt_id: NCBITaxon:159853 -alt_id: NCBITaxon:50611 -synonym: "Paramyxine" RELATED synonym [] -xref: GC_ID:1 -is_a: NCBITaxon:30309 ! Eptatretinae -property_value: has_rank NCBITaxon:genus - -[Term] -id: NCBITaxon:7764 -name: Eptatretus burgeri -namespace: ncbi_taxonomy -synonym: "Bdellostoma burgeri" RELATED synonym [] -synonym: "inshore hagfish" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:7763 ! Eptatretus -property_value: has_rank NCBITaxon:species - -[Term] -id: NCBITaxon:7769 -name: Myxine glutinosa -namespace: ncbi_taxonomy -synonym: "Atlantic hagfish" EXACT genbank_common_name [] -synonym: "common hagfish" EXACT common_name [] -synonym: "hagfish" EXACT common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:110555 ! Myxine -property_value: has_rank NCBITaxon:species - -[Term] -id: NCBITaxon:7776 -name: Gnathostomata -namespace: ncbi_taxonomy -synonym: "Gnathostomata" EXACT scientific_name [] -synonym: "jawed vertebrates" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:7742 ! Vertebrata - -[Term] -id: NCBITaxon:7777 -name: Chondrichthyes -namespace: ncbi_taxonomy -synonym: "cartilaginous fishes" EXACT genbank_common_name [] -synonym: "cartilaginous fishes" RELATED blast_name [] -synonym: "fish" EXACT common_name [] -synonym: "fishes" EXACT common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:7776 ! Gnathostomata -property_value: has_rank NCBITaxon:class - -[Term] -id: NCBITaxon:7778 -name: Elasmobranchii -namespace: ncbi_taxonomy -synonym: "elasmobranchs" EXACT genbank_common_name [] -synonym: "sharks and rays" RELATED blast_name [] -xref: GC_ID:1 -is_a: NCBITaxon:7777 ! Chondrichthyes -property_value: has_rank NCBITaxon:subclass - -[Term] -id: NCBITaxon:7863 -name: Holocephali -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:7777 ! Chondrichthyes -property_value: has_rank NCBITaxon:subclass - -[Term] -id: NCBITaxon:7864 -name: Chimaeriformes -namespace: ncbi_taxonomy -synonym: "chimaeras" EXACT genbank_common_name [] -synonym: "chimaeras" RELATED blast_name [] -xref: GC_ID:1 -is_a: NCBITaxon:7863 ! Holocephali -property_value: has_rank NCBITaxon:order - -[Term] -id: NCBITaxon:7878 -name: Dipnoi -namespace: ncbi_taxonomy -synonym: "Choanichthyes" RELATED in_part [] -synonym: "Dipneusti" RELATED synonym [] -synonym: "dipnoans" EXACT common_name [] -synonym: "Dipnomorpha" RELATED synonym [] -synonym: "fish" EXACT common_name [] -synonym: "fishes" EXACT common_name [] -synonym: "lungfishes" EXACT genbank_common_name [] -synonym: "lungfishes" RELATED blast_name [] -synonym: "Osteichthyes" RELATED in_part [] -xref: GC_ID:1 -is_a: NCBITaxon:1338369 ! Dipnotetrapodomorpha - -[Term] -id: NCBITaxon:7898 -name: Actinopterygii -namespace: ncbi_taxonomy -synonym: "Actinopterygi" RELATED synonym [] -synonym: "bony fishes" RELATED blast_name [] -synonym: "fish" EXACT common_name [] -synonym: "fishes" EXACT common_name [] -synonym: "Osteichthyes" RELATED in_part [] -synonym: "ray-finned fishes" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:117571 ! Euteleostomi -property_value: has_rank NCBITaxon:superclass - -[Term] -id: NCBITaxon:7933 -name: Anguilliformes -namespace: ncbi_taxonomy -alt_id: NCBITaxon:30678 -synonym: "eels" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:32521 ! Elopomorpha -property_value: has_rank NCBITaxon:order - -[Term] -id: NCBITaxon:7952 -name: Cypriniformes -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:186627 ! Cypriniphysae -property_value: has_rank NCBITaxon:order - -[Term] -id: NCBITaxon:7953 -name: Cyprinidae -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:30727 ! Cyprinoidea -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:7954 -name: Danio -namespace: ncbi_taxonomy -alt_id: NCBITaxon:46777 -alt_id: NCBITaxon:487617 -synonym: "Brachydanio" RELATED synonym [] -synonym: "Celestichthys" RELATED synonym [] -xref: GC_ID:1 -is_a: NCBITaxon:7953 ! Cyprinidae -property_value: has_rank NCBITaxon:genus - -[Term] -id: NCBITaxon:7955 -name: Danio rerio -namespace: ncbi_taxonomy -alt_id: NCBITaxon:27702 -alt_id: NCBITaxon:37966 -synonym: "Brachidanio rerio" RELATED misspelling [] -synonym: "Brachydanio rerio" RELATED synonym [] -synonym: "Brachydanio rerio frankei" RELATED synonym [] -synonym: "Cyprinus rerio" RELATED synonym [] -synonym: "Danio frankei" RELATED synonym [] -synonym: "Danio rerio frankei" RELATED synonym [] -synonym: "leopard danio" EXACT common_name [] -synonym: "zebra danio" EXACT common_name [] -synonym: "zebra fish" EXACT common_name [] -synonym: "zebrafish" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:7954 ! Danio -property_value: has_rank NCBITaxon:species - -[Term] -id: NCBITaxon:8075 -name: Atheriniformes -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:1489913 ! Atherinomorphae -property_value: has_rank NCBITaxon:order - -[Term] -id: NCBITaxon:8088 -name: Oryziinae -namespace: ncbi_taxonomy -synonym: "medakas" EXACT genbank_common_name [] -synonym: "Oryziatinae" RELATED synonym [] -synonym: "ricefishes" EXACT common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:47757 ! Adrianichthyidae -property_value: has_rank NCBITaxon:subfamily - -[Term] -id: NCBITaxon:8089 -name: Oryzias -namespace: ncbi_taxonomy -alt_id: NCBITaxon:123687 -synonym: "Orizias" RELATED misspelling [] -synonym: "Xenopoecilus" RELATED synonym [] -xref: GC_ID:1 -is_a: NCBITaxon:8088 ! Oryziinae -property_value: has_rank NCBITaxon:genus - -[Term] -id: NCBITaxon:8090 -name: Oryzias latipes -namespace: ncbi_taxonomy -synonym: "Japanese medaka" EXACT genbank_common_name [] -synonym: "Japanese rice fish" EXACT common_name [] -synonym: "medaka" EXACT common_name [] -synonym: "Orizias latipes" RELATED misspelling [] -synonym: "Poecilia latipes" RELATED synonym [] -xref: GC_ID:1 -is_a: NCBITaxon:8089 ! Oryzias -property_value: has_rank NCBITaxon:species - -[Term] -id: NCBITaxon:80999 -name: Homoscleromorpha -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:6040 ! Porifera -property_value: has_rank NCBITaxon:class - -[Term] -id: NCBITaxon:81957 -name: Polychrotidae -namespace: ncbi_taxonomy -alt_id: NCBITaxon:42423 -alt_id: NCBITaxon:43613 -synonym: "Anolinae" RELATED misnomer [] -synonym: "Polychrinae" RELATED synonym [] -synonym: "Polychrotinae" RELATED synonym [] -xref: GC_ID:1 -is_a: NCBITaxon:8511 ! Iguania -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:8287 -name: Sarcopterygii -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:117571 ! Euteleostomi -property_value: has_rank NCBITaxon:superclass - -[Term] -id: NCBITaxon:8292 -name: Amphibia -namespace: ncbi_taxonomy -synonym: "amphibians" EXACT genbank_common_name [] -synonym: "amphibians" RELATED blast_name [] -xref: GC_ID:1 -is_a: NCBITaxon:32523 ! Tetrapoda -property_value: has_rank NCBITaxon:class - -[Term] -id: NCBITaxon:8293 -name: Caudata -namespace: ncbi_taxonomy -synonym: "salamanders" RELATED blast_name [] -synonym: "Urodela" RELATED synonym [] -xref: GC_ID:1 -is_a: NCBITaxon:41666 ! Batrachia -property_value: has_rank NCBITaxon:order - -[Term] -id: NCBITaxon:8342 -name: Anura -namespace: ncbi_taxonomy -synonym: "anurans" EXACT common_name [] -synonym: "frogs" EXACT common_name [] -synonym: "frogs & toads" RELATED blast_name [] -synonym: "frogs and toads" EXACT genbank_common_name [] -synonym: "Salientia" RELATED synonym [] -xref: GC_ID:1 -is_a: NCBITaxon:41666 ! Batrachia -property_value: has_rank NCBITaxon:order - -[Term] -id: NCBITaxon:8352 -name: Pipidae -namespace: ncbi_taxonomy -synonym: "pipid frogs" EXACT common_name [] -synonym: "tongueless frogs" EXACT genbank_common_name [] -xref: GC_ID:1 -xref: PMID:2385174 -is_a: NCBITaxon:30319 ! Pipoidea -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:8353 -name: Xenopus -namespace: ncbi_taxonomy -synonym: "Xenopus" EXACT scientific_name [] -xref: GC_ID:1 -xref: PMID:2385174 -is_a: NCBITaxon:8360 ! Xenopodinae -property_value: has_rank NCBITaxon:genus - -[Term] -id: NCBITaxon:8355 -name: Xenopus laevis -namespace: ncbi_taxonomy -synonym: "African clawed frog" EXACT genbank_common_name [] -synonym: "Bufo laevis" RELATED synonym [] -synonym: "clawed frog" EXACT common_name [] -synonym: "common platanna" EXACT common_name [] -synonym: "platanna" EXACT common_name [] -synonym: "Xenopus leavis" RELATED misspelling [] -xref: GC_ID:1 -is_a: NCBITaxon:262014 ! Xenopus -property_value: has_rank NCBITaxon:species - -[Term] -id: NCBITaxon:8360 -name: Xenopodinae -namespace: ncbi_taxonomy -synonym: "Siluraninae" RELATED synonym [] -xref: GC_ID:1 -xref: PMID:2385174 -is_a: NCBITaxon:8352 ! Pipidae -property_value: has_rank NCBITaxon:subfamily - -[Term] -id: NCBITaxon:8445 -name: Gymnophiona -namespace: ncbi_taxonomy -alt_id: NCBITaxon:30377 -synonym: "caecilians" RELATED blast_name [] -xref: GC_ID:1 -is_a: NCBITaxon:8292 ! Amphibia -property_value: has_rank NCBITaxon:order - -[Term] -id: NCBITaxon:8446 -name: Caeciliidae -namespace: ncbi_taxonomy -alt_id: NCBITaxon:264007 -synonym: "Caeciliinae" RELATED synonym [] -synonym: "true caecilians" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:8445 ! Gymnophiona -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:8457 -name: Sauropsida -namespace: ncbi_taxonomy -synonym: "sauropsids" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:32524 ! Amniota - -[Term] -id: NCBITaxon:8459 -name: Testudines -namespace: ncbi_taxonomy -synonym: "anapsid reptiles" EXACT common_name [] -synonym: "Anapsida" RELATED synonym [] -synonym: "reptiles" RELATED in_part [] -synonym: "Reptilia" RELATED in_part [] -synonym: "Testudinata" RELATED synonym [] -synonym: "turtles" EXACT genbank_common_name [] -synonym: "turtles" RELATED blast_name [] -xref: GC_ID:1 -xref: PMID:22839753 -xref: PMID:25450099 -is_a: NCBITaxon:1329799 ! Archelosauria -property_value: has_rank NCBITaxon:order - -[Term] -id: NCBITaxon:8492 -name: Archosauria -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:1329799 ! Archelosauria - -[Term] -id: NCBITaxon:8493 -name: Crocodylidae -namespace: ncbi_taxonomy -alt_id: NCBITaxon:8494 -synonym: "crocodiles" RELATED blast_name [] -synonym: "crocodilians" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:1298654 ! Longirostres -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:8504 -name: Lepidosauria -namespace: ncbi_taxonomy -synonym: "lepidosaurs" EXACT genbank_common_name [] -synonym: "lizards" RELATED blast_name [] -synonym: "reptiles" RELATED in_part [] -synonym: "Reptilia" RELATED in_part [] -xref: GC_ID:1 -xref: PMID:22982760 -is_a: NCBITaxon:32561 ! Sauria -property_value: has_rank NCBITaxon:superorder - -[Term] -id: NCBITaxon:8505 -name: Sphenodontia -namespace: ncbi_taxonomy -synonym: "beaked reptiles" EXACT genbank_common_name [] -synonym: "Rhynchocephalia" RELATED synonym [] -synonym: "rhynchocephalians" EXACT common_name [] -synonym: "Rhynchosauria" RELATED synonym [] -xref: GC_ID:1 -is_a: NCBITaxon:8504 ! Lepidosauria -property_value: has_rank NCBITaxon:order - -[Term] -id: NCBITaxon:8506 -name: Sphenodontidae -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:8505 ! Sphenodontia -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:8507 -name: Sphenodon -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:8506 ! Sphenodontidae -property_value: has_rank NCBITaxon:genus - -[Term] -id: NCBITaxon:8508 -name: Sphenodon punctatus -namespace: ncbi_taxonomy -synonym: "hatteria" EXACT common_name [] -synonym: "Hatteria punctata" RELATED synonym [] -synonym: "tuatara" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:8507 ! Sphenodon -property_value: has_rank NCBITaxon:species - -[Term] -id: NCBITaxon:8509 -name: Squamata -namespace: ncbi_taxonomy -synonym: "squamates" EXACT genbank_common_name [] -xref: GC_ID:1 -xref: PMID:16286089 -xref: PMID:22982760 -xref: PMID:23627680 -is_a: NCBITaxon:8504 ! Lepidosauria -property_value: has_rank NCBITaxon:order - -[Term] -id: NCBITaxon:8511 -name: Iguania -namespace: ncbi_taxonomy -synonym: "iguanian lizards" EXACT genbank_common_name [] -synonym: "Lacertilia" RELATED in_part [] -xref: GC_ID:1 -xref: PMID:19281946 -xref: PMID:9169559 -is_a: NCBITaxon:1329911 ! Toxicofera -property_value: has_rank NCBITaxon:suborder - -[Term] -id: NCBITaxon:8515 -name: Iguanidae -namespace: ncbi_taxonomy -synonym: "iguanid lizards" EXACT genbank_common_name [] -xref: GC_ID:1 -xref: PMID:10051389 -xref: PMID:9169559 -is_a: NCBITaxon:8511 ! Iguania -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:85512 -name: Dicondylia -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:50557 ! Insecta - -[Term] -id: NCBITaxon:85604 -name: Amphiesmenoptera -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:33392 ! Holometabola - -[Term] -id: NCBITaxon:8570 -name: Serpentes -namespace: ncbi_taxonomy -synonym: "Ophidia" RELATED synonym [] -synonym: "snakes" EXACT genbank_common_name [] -synonym: "snakes" RELATED blast_name [] -xref: GC_ID:1 -xref: PMID:19281946 -is_a: NCBITaxon:1329911 ! Toxicofera -property_value: has_rank NCBITaxon:infraorder - -[Term] -id: NCBITaxon:8578 -name: Colubridae -namespace: ncbi_taxonomy -synonym: "colubrid snakes" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:34989 ! Colubroidea -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:862507 -name: Mus -namespace: ncbi_taxonomy -synonym: "Mus" EXACT scientific_name [] -xref: GC_ID:1 -is_a: NCBITaxon:10088 ! Mus -property_value: has_rank NCBITaxon:subgenus - -[Term] -id: NCBITaxon:8782 -name: Aves -namespace: ncbi_taxonomy -synonym: "avian" RELATED synonym [] -synonym: "birds" EXACT genbank_common_name [] -synonym: "birds" RELATED blast_name [] -xref: GC_ID:1 -is_a: NCBITaxon:436492 ! Coelurosauria -property_value: has_rank NCBITaxon:class - -[Term] -id: NCBITaxon:8825 -name: Neognathae -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:8782 ! Aves -property_value: has_rank NCBITaxon:superorder - -[Term] -id: NCBITaxon:8826 -name: Anseriformes -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:1549675 ! Galloanserae -property_value: has_rank NCBITaxon:order - -[Term] -id: NCBITaxon:8827 -name: Anhimidae -namespace: ncbi_taxonomy -synonym: "screamers" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:8826 ! Anseriformes -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:88770 -name: Panarthropoda -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:1206794 ! Ecdysozoa - -[Term] -id: NCBITaxon:89593 -name: Craniata -namespace: ncbi_taxonomy -synonym: "Craniata" EXACT scientific_name [] -xref: GC_ID:1 -is_a: NCBITaxon:7711 ! Chordata -property_value: has_rank NCBITaxon:subphylum - -[Term] -id: NCBITaxon:8976 -name: Galliformes -namespace: ncbi_taxonomy -synonym: "fowls" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:1549675 ! Galloanserae -property_value: has_rank NCBITaxon:order - -[Term] -id: NCBITaxon:9005 -name: Phasianidae -namespace: ncbi_taxonomy -alt_id: NCBITaxon:9099 -synonym: "turkeys" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:8976 ! Galliformes -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:9030 -name: Gallus -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:9072 ! Phasianinae -property_value: has_rank NCBITaxon:genus - -[Term] -id: NCBITaxon:9031 -name: Gallus gallus -namespace: ncbi_taxonomy -synonym: "bantam" EXACT common_name [] -synonym: "chicken" EXACT genbank_common_name [] -synonym: "chickens" EXACT common_name [] -synonym: "Gallus domesticus" RELATED misnomer [] -synonym: "Gallus gallus domesticus" RELATED synonym [] -xref: GC_ID:1 -is_a: NCBITaxon:9030 ! Gallus -property_value: has_rank NCBITaxon:species - -[Term] -id: NCBITaxon:9072 -name: Phasianinae -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:9005 ! Phasianidae -property_value: has_rank NCBITaxon:subfamily - -[Term] -id: NCBITaxon:91561 -name: Cetartiodactyla -namespace: ncbi_taxonomy -synonym: "even-toed ungulates" RELATED blast_name [] -synonym: "whales, hippos, ruminants, pigs, camels etc." EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:314145 ! Laurasiatheria - -[Term] -id: NCBITaxon:9254 -name: Prototheria -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:40674 ! Mammalia - -[Term] -id: NCBITaxon:9255 -name: Monotremata -namespace: ncbi_taxonomy -synonym: "egg-laying mammals" EXACT genbank_common_name [] -synonym: "monotremes" RELATED blast_name [] -xref: GC_ID:1 -is_a: NCBITaxon:9254 ! Prototheria -property_value: has_rank NCBITaxon:order - -[Term] -id: NCBITaxon:9256 -name: Ornithorhynchidae -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:9255 ! Monotremata -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:9257 -name: Ornithorhynchus -namespace: ncbi_taxonomy -synonym: "Ornythorhynchus" RELATED misspelling [] -xref: GC_ID:1 -is_a: NCBITaxon:9256 ! Ornithorhynchidae -property_value: has_rank NCBITaxon:genus - -[Term] -id: NCBITaxon:9258 -name: Ornithorhynchus anatinus -namespace: ncbi_taxonomy -synonym: "duck-billed platypus" EXACT common_name [] -synonym: "duckbill platypus" EXACT common_name [] -synonym: "Ornythorhynchus anatinus" RELATED misspelling [] -synonym: "platypus" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:9257 ! Ornithorhynchus -property_value: has_rank NCBITaxon:species - -[Term] -id: NCBITaxon:9259 -name: Tachyglossidae -namespace: ncbi_taxonomy -synonym: "echidnas" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:9255 ! Monotremata -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:9263 -name: Metatheria -namespace: ncbi_taxonomy -synonym: "Marsupialia" RELATED synonym [] -synonym: "marsupials" EXACT genbank_common_name [] -synonym: "marsupials" RELATED blast_name [] -xref: GC_ID:1 -is_a: NCBITaxon:32525 ! Theria - -[Term] -id: NCBITaxon:9265 -name: Didelphidae -namespace: ncbi_taxonomy -synonym: "American opossums" EXACT common_name [] -synonym: "opossums" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:38605 ! Didelphimorphia -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:9307 -name: Macropodidae -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:38609 ! Diprotodontia -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:9312 -name: Macropus -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:9307 ! Macropodidae -property_value: has_rank NCBITaxon:genus - -[Term] -id: NCBITaxon:9321 -name: Osphranter rufus -namespace: ncbi_taxonomy -synonym: "Macropus rufus" RELATED synonym [] -synonym: "Megaleia rufa" RELATED synonym [] -synonym: "red kangaroo" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:2182372 ! Osphranter -property_value: has_rank NCBITaxon:species - -[Term] -id: NCBITaxon:9347 -name: Eutheria -namespace: ncbi_taxonomy -synonym: "eutherian mammals" EXACT common_name [] -synonym: "placental mammals" EXACT common_name [] -synonym: "Placentalia" RELATED synonym [] -synonym: "placentals" EXACT genbank_common_name [] -synonym: "placentals" RELATED blast_name [] -xref: GC_ID:1 -is_a: NCBITaxon:32525 ! Theria - -[Term] -id: NCBITaxon:9348 -name: Xenarthra -namespace: ncbi_taxonomy -synonym: "Edentata" RELATED in_part [] -xref: GC_ID:1 -xref: PMID:11214319 -is_a: NCBITaxon:9347 ! Eutheria -property_value: has_rank NCBITaxon:superorder - -[Term] -id: NCBITaxon:9359 -name: Dasypodidae -namespace: ncbi_taxonomy -synonym: "armadillo" EXACT common_name [] -synonym: "armadillos" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:948951 ! Cingulata -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:9362 -name: Insectivora -namespace: ncbi_taxonomy -synonym: "hedgehogs, shrews, moles and others" EXACT genbank_common_name [] -synonym: "insectivores" RELATED blast_name [] -synonym: "Soricomorpha" RELATED synonym [] -xref: GC_ID:1 -is_a: NCBITaxon:314145 ! Laurasiatheria -property_value: has_rank NCBITaxon:order - -[Term] -id: NCBITaxon:9363 -name: Erinaceidae -namespace: ncbi_taxonomy -synonym: "hedgehogs" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:9362 ! Insectivora -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:9364 -name: Erinaceus -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:30577 ! Erinaceinae -property_value: has_rank NCBITaxon:genus - -[Term] -id: NCBITaxon:9365 -name: Erinaceus europaeus -namespace: ncbi_taxonomy -synonym: "common hedgehog" EXACT common_name [] -synonym: "Erinaceous europaeus" RELATED misspelling [] -synonym: "Erinaceus europeus" RELATED misspelling [] -synonym: "European hedgehog" EXACT common_name [] -synonym: "western European hedgehog" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:9364 ! Erinaceus -property_value: has_rank NCBITaxon:species - -[Term] -id: NCBITaxon:9369 -name: Tenrecidae -namespace: ncbi_taxonomy -synonym: "tenrecs" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:311790 ! Afrotheria -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:9373 -name: Talpidae -namespace: ncbi_taxonomy -synonym: "moles, shrew-moles, and desmans" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:9362 ! Insectivora -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:9397 -name: Chiroptera -namespace: ncbi_taxonomy -synonym: "bats" EXACT genbank_common_name [] -synonym: "bats" RELATED blast_name [] -xref: GC_ID:1 -is_a: NCBITaxon:314145 ! Laurasiatheria -property_value: has_rank NCBITaxon:order - -[Term] -id: NCBITaxon:9443 -name: Primates -namespace: ncbi_taxonomy -synonym: "Primata" RELATED synonym [] -synonym: "primate" EXACT equivalent_name [] -synonym: "primates" RELATED blast_name [] -xref: GC_ID:1 -is_a: NCBITaxon:314146 ! Euarchontoglires -property_value: has_rank NCBITaxon:order - -[Term] -id: NCBITaxon:9475 -name: Tarsiidae -namespace: ncbi_taxonomy -synonym: "tarsiers" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:376912 ! Tarsiiformes -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:9479 -name: Platyrrhini -namespace: ncbi_taxonomy -synonym: "monkey" EXACT common_name [] -synonym: "monkeys" EXACT common_name [] -synonym: "New World monkeys" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:314293 ! Simiiformes -property_value: has_rank NCBITaxon:parvorder - -[Term] -id: NCBITaxon:948951 -name: Cingulata -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:9348 ! Xenarthra -property_value: has_rank NCBITaxon:order - -[Term] -id: NCBITaxon:94929 -name: Ophidiiformes -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:1489873 ! Ophidiaria -property_value: has_rank NCBITaxon:order - -[Term] -id: NCBITaxon:9499 -name: Alouatta -namespace: ncbi_taxonomy -synonym: "howler monkeys" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:38066 ! Alouattinae -property_value: has_rank NCBITaxon:genus - -[Term] -id: NCBITaxon:9526 -name: Catarrhini -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:314293 ! Simiiformes -property_value: has_rank NCBITaxon:parvorder - -[Term] -id: NCBITaxon:9527 -name: Cercopithecidae -namespace: ncbi_taxonomy -synonym: "monkey" EXACT common_name [] -synonym: "monkeys" EXACT common_name [] -synonym: "Old World monkeys" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:314294 ! Cercopithecoidea -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:9528 -name: Cercopithecinae -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:9527 ! Cercopithecidae -property_value: has_rank NCBITaxon:subfamily - -[Term] -id: NCBITaxon:9539 -name: Macaca -namespace: ncbi_taxonomy -synonym: "macaque" EXACT common_name [] -synonym: "macaques" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:9528 ! Cercopithecinae -property_value: has_rank NCBITaxon:genus - -[Term] -id: NCBITaxon:9544 -name: Macaca mulatta -namespace: ncbi_taxonomy -alt_id: NCBITaxon:36502 -synonym: "rhesus macaque" EXACT common_name [] -synonym: "rhesus macaques" EXACT common_name [] -synonym: "Rhesus monkey" EXACT genbank_common_name [] -synonym: "rhesus monkeys" EXACT common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:9539 ! Macaca -property_value: has_rank NCBITaxon:species - -[Term] -id: NCBITaxon:9592 -name: Gorilla -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:207598 ! Homininae -property_value: has_rank NCBITaxon:genus - -[Term] -id: NCBITaxon:9593 -name: Gorilla gorilla -namespace: ncbi_taxonomy -synonym: "gorilla" EXACT common_name [] -synonym: "Troglodytes gorilla" RELATED synonym [] -synonym: "western gorilla" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:9592 ! Gorilla -property_value: has_rank NCBITaxon:species - -[Term] -id: NCBITaxon:9596 -name: Pan -namespace: ncbi_taxonomy -alt_id: NCBITaxon:317028 -alt_id: NCBITaxon:445518 -synonym: "chimpanzees" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:207598 ! Homininae -property_value: has_rank NCBITaxon:genus - -[Term] -id: NCBITaxon:9597 -name: Pan paniscus -namespace: ncbi_taxonomy -synonym: "bonobo" EXACT common_name [] -synonym: "pygmy chimpanzee" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:9596 ! Pan -property_value: has_rank NCBITaxon:species - -[Term] -id: NCBITaxon:9598 -name: Pan troglodytes -namespace: ncbi_taxonomy -synonym: "Chimpansee troglodytes" RELATED misspelling [] -synonym: "chimpanzee" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:9596 ! Pan -property_value: has_rank NCBITaxon:species - -[Term] -id: NCBITaxon:9599 -name: Pongo -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:607660 ! Ponginae -property_value: has_rank NCBITaxon:genus - -[Term] -id: NCBITaxon:9600 -name: Pongo pygmaeus -namespace: ncbi_taxonomy -synonym: "Bornean orangutan" EXACT genbank_common_name [] -synonym: "orang utan" EXACT common_name [] -synonym: "Orang-utan" EXACT common_name [] -synonym: "Orangutan" EXACT common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:9599 ! Pongo -property_value: has_rank NCBITaxon:species - -[Term] -id: NCBITaxon:9604 -name: Hominidae -namespace: ncbi_taxonomy -synonym: "great apes" EXACT genbank_common_name [] -synonym: "Pongidae" RELATED synonym [] -xref: GC_ID:1 -is_a: NCBITaxon:314295 ! Hominoidea -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:9605 -name: Homo -namespace: ncbi_taxonomy -synonym: "humans" EXACT common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:207598 ! Homininae -property_value: has_rank NCBITaxon:genus - -[Term] -id: NCBITaxon:9606 -name: Homo sapiens -namespace: ncbi_taxonomy -synonym: "Home sapiens" RELATED misspelling [] -synonym: "Homo sampiens" RELATED misspelling [] -synonym: "Homo sapeins" RELATED misspelling [] -synonym: "Homo sapian" RELATED misspelling [] -synonym: "Homo sapians" RELATED misspelling [] -synonym: "Homo sapien" RELATED misspelling [] -synonym: "Homo sapience" RELATED misspelling [] -synonym: "Homo sapiense" RELATED misspelling [] -synonym: "Homo sapients" RELATED misspelling [] -synonym: "Homo sapines" RELATED misspelling [] -synonym: "Homo spaiens" RELATED misspelling [] -synonym: "Homo spiens" RELATED misspelling [] -synonym: "human" EXACT genbank_common_name [] -synonym: "Humo sapiens" RELATED misspelling [] -synonym: "man" EXACT common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:9605 ! Homo -property_value: has_rank NCBITaxon:species - -[Term] -id: NCBITaxon:9608 -name: Canidae -namespace: ncbi_taxonomy -synonym: "dog, coyote, wolf, fox" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:379584 ! Caniformia -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:9611 -name: Canis -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:9608 ! Canidae -property_value: has_rank NCBITaxon:genus - -[Term] -id: NCBITaxon:9681 -name: Felidae -namespace: ncbi_taxonomy -synonym: "cat family" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:379583 ! Feliformia -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:9709 -name: Phocidae -namespace: ncbi_taxonomy -synonym: "crawling seals" EXACT common_name [] -synonym: "earless seals" EXACT common_name [] -synonym: "seal" EXACT common_name [] -synonym: "seals" EXACT common_name [] -synonym: "true seals" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:379584 ! Caniformia -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:9721 -name: Cetacea -namespace: ncbi_taxonomy -synonym: "cetaceans" RELATED synonym [] -synonym: "whale" EXACT common_name [] -synonym: "whales" EXACT genbank_common_name [] -synonym: "whales & dolphins" RELATED blast_name [] -synonym: "whales, dolphins, and porpoises" EXACT common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:91561 ! Cetartiodactyla -property_value: has_rank NCBITaxon:order - -[Term] -id: NCBITaxon:9722 -name: Odontoceti -namespace: ncbi_taxonomy -synonym: "tooth whales" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:9721 ! Cetacea -property_value: has_rank NCBITaxon:suborder - -[Term] -id: NCBITaxon:9747 -name: Monodontidae -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:9722 ! Odontoceti -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:9750 -name: Physeteridae -namespace: ncbi_taxonomy -synonym: "sperm whales" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:9722 ! Odontoceti -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:9753 -name: Physeter -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:9750 ! Physeteridae -property_value: has_rank NCBITaxon:genus - -[Term] -id: NCBITaxon:9761 -name: Mysticeti -namespace: ncbi_taxonomy -synonym: "baleen whales" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:9721 ! Cetacea -property_value: has_rank NCBITaxon:suborder - -[Term] -id: NCBITaxon:9765 -name: Balaenopteridae -namespace: ncbi_taxonomy -synonym: "finback whales" EXACT common_name [] -synonym: "rorquals" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:9761 ! Mysticeti -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:9774 -name: Sirenia -namespace: ncbi_taxonomy -synonym: "manatees and dugongs (seacows)" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:311790 ! Afrotheria -property_value: has_rank NCBITaxon:order - -[Term] -id: NCBITaxon:9775 -name: Trichechidae -namespace: ncbi_taxonomy -synonym: "manatees" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:9774 ! Sirenia -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:9779 -name: Proboscidea -namespace: ncbi_taxonomy -synonym: "elephants" EXACT genbank_common_name [] -synonym: "Proboscidea" EXACT scientific_name [] -xref: GC_ID:1 -is_a: NCBITaxon:311790 ! Afrotheria -property_value: has_rank NCBITaxon:order - -[Term] -id: NCBITaxon:9787 -name: Perissodactyla -namespace: ncbi_taxonomy -synonym: "odd-toed ungulates" EXACT genbank_common_name [] -synonym: "odd-toed ungulates" RELATED blast_name [] -xref: GC_ID:1 -is_a: NCBITaxon:314145 ! Laurasiatheria -property_value: has_rank NCBITaxon:order - -[Term] -id: NCBITaxon:9788 -name: Equidae -namespace: ncbi_taxonomy -synonym: "horses" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:9787 ! Perissodactyla -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:9815 -name: Tubulidentata -namespace: ncbi_taxonomy -synonym: "aardvarks" EXACT genbank_common_name [] -synonym: "Edentata" RELATED in_part [] -xref: GC_ID:1 -is_a: NCBITaxon:311790 ! Afrotheria -property_value: has_rank NCBITaxon:order - -[Term] -id: NCBITaxon:9816 -name: Orycteropodidae -namespace: ncbi_taxonomy -synonym: "aardvark" EXACT genbank_common_name [] -synonym: "aardvarks" EXACT common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:9815 ! Tubulidentata -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:9821 -name: Suidae -namespace: ncbi_taxonomy -alt_id: NCBITaxon:39423 -synonym: "boars" EXACT common_name [] -synonym: "pigs" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:35497 ! Suina -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:9822 -name: Sus -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:9821 ! Suidae -property_value: has_rank NCBITaxon:genus - -[Term] -id: NCBITaxon:9823 -name: Sus scrofa -namespace: ncbi_taxonomy -synonym: "pig" EXACT genbank_common_name [] -synonym: "pigs" EXACT common_name [] -synonym: "Sus scrofus" RELATED misspelling [] -synonym: "swine" EXACT common_name [] -synonym: "wild boar" EXACT common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:9822 ! Sus -property_value: has_rank NCBITaxon:species - -[Term] -id: NCBITaxon:9834 -name: Tylopoda -namespace: ncbi_taxonomy -synonym: "Artiodactyla" RELATED in_part [] -xref: GC_ID:1 -is_a: NCBITaxon:91561 ! Cetartiodactyla -property_value: has_rank NCBITaxon:suborder - -[Term] -id: NCBITaxon:9835 -name: Camelidae -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:9834 ! Tylopoda -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:9836 -name: Camelus -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:9835 ! Camelidae -property_value: has_rank NCBITaxon:genus - -[Term] -id: NCBITaxon:9845 -name: Ruminantia -namespace: ncbi_taxonomy -synonym: "Artiodactyla" RELATED in_part [] -xref: GC_ID:1 -is_a: NCBITaxon:91561 ! Cetartiodactyla -property_value: has_rank NCBITaxon:suborder - -[Term] -id: NCBITaxon:9850 -name: Cervidae -namespace: ncbi_taxonomy -synonym: "deer" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:35500 ! Pecora -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:9892 -name: Giraffidae -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:35500 ! Pecora -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:9895 -name: Bovidae -namespace: ncbi_taxonomy -xref: GC_ID:1 -is_a: NCBITaxon:35500 ! Pecora -property_value: has_rank NCBITaxon:family - -[Term] -id: NCBITaxon:9903 -name: Bos -namespace: ncbi_taxonomy -synonym: "oxen, cattle" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:27592 ! Bovinae -property_value: has_rank NCBITaxon:genus - -[Term] -id: NCBITaxon:9913 -name: Bos taurus -namespace: ncbi_taxonomy -alt_id: NCBITaxon:272461 -synonym: "Bos bovis" RELATED synonym [] -synonym: "Bos primigenius taurus" RELATED synonym [] -synonym: "Bos Tauurus" RELATED misspelling [] -synonym: "bovine" EXACT common_name [] -synonym: "cattle" EXACT genbank_common_name [] -synonym: "cow" EXACT common_name [] -synonym: "dairy cow" EXACT common_name [] -synonym: "domestic cattle" EXACT common_name [] -synonym: "domestic cow" EXACT common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:9903 ! Bos -property_value: has_rank NCBITaxon:species - -[Term] -id: NCBITaxon:9975 -name: Lagomorpha -namespace: ncbi_taxonomy -synonym: "rabbits & hares" RELATED blast_name [] -xref: GC_ID:1 -is_a: NCBITaxon:314147 ! Glires -property_value: has_rank NCBITaxon:order - -[Term] -id: NCBITaxon:99883 -name: Tetraodon nigroviridis -namespace: ncbi_taxonomy -synonym: "spotted green pufferfish" EXACT genbank_common_name [] -xref: GC_ID:1 -is_a: NCBITaxon:47144 ! Tetraodon -property_value: has_rank NCBITaxon:species - -[Term] -id: NCBITaxon:9989 -name: Rodentia -namespace: ncbi_taxonomy -synonym: "rodent" EXACT genbank_common_name [] -synonym: "rodents" RELATED blast_name [] +id: NCBITaxon:9989 +name: Rodentia xref: GC_ID:1 is_a: NCBITaxon:314147 ! Glires -property_value: has_rank NCBITaxon:order - -[Term] -id: NCBITaxon:class -name: class -namespace: ncbi_taxonomy -is_a: NCBITaxon:taxonomic_rank ! taxonomic rank - -[Term] -id: NCBITaxon:family -name: family -namespace: ncbi_taxonomy -is_a: NCBITaxon:taxonomic_rank ! taxonomic rank - -[Term] -id: NCBITaxon:genus -name: genus -namespace: ncbi_taxonomy -is_a: NCBITaxon:taxonomic_rank ! taxonomic rank - -[Term] -id: NCBITaxon:infraclass -name: infraclass -namespace: ncbi_taxonomy -is_a: NCBITaxon:taxonomic_rank ! taxonomic rank - -[Term] -id: NCBITaxon:infraorder -name: infraorder -namespace: ncbi_taxonomy -is_a: NCBITaxon:taxonomic_rank ! taxonomic rank - -[Term] -id: NCBITaxon:kingdom -name: kingdom -namespace: ncbi_taxonomy -is_a: NCBITaxon:taxonomic_rank ! taxonomic rank - -[Term] -id: NCBITaxon:order -name: order -namespace: ncbi_taxonomy -is_a: NCBITaxon:taxonomic_rank ! taxonomic rank - -[Term] -id: NCBITaxon:parvorder -name: parvorder -namespace: ncbi_taxonomy -is_a: NCBITaxon:taxonomic_rank ! taxonomic rank - -[Term] -id: NCBITaxon:phylum -name: phylum -namespace: ncbi_taxonomy -is_a: NCBITaxon:taxonomic_rank ! taxonomic rank - -[Term] -id: NCBITaxon:species -name: species -namespace: ncbi_taxonomy -is_a: NCBITaxon:taxonomic_rank ! taxonomic rank - -[Term] -id: NCBITaxon:subclass -name: subclass -namespace: ncbi_taxonomy -is_a: NCBITaxon:taxonomic_rank ! taxonomic rank - -[Term] -id: NCBITaxon:subfamily -name: subfamily -namespace: ncbi_taxonomy -is_a: NCBITaxon:taxonomic_rank ! taxonomic rank - -[Term] -id: NCBITaxon:subgenus -name: subgenus -namespace: ncbi_taxonomy -is_a: NCBITaxon:taxonomic_rank ! taxonomic rank - -[Term] -id: NCBITaxon:suborder -name: suborder -namespace: ncbi_taxonomy -is_a: NCBITaxon:taxonomic_rank ! taxonomic rank - -[Term] -id: NCBITaxon:subphylum -name: subphylum -namespace: ncbi_taxonomy -is_a: NCBITaxon:taxonomic_rank ! taxonomic rank - -[Term] -id: NCBITaxon:superclass -name: superclass -namespace: ncbi_taxonomy -is_a: NCBITaxon:taxonomic_rank ! taxonomic rank - -[Term] -id: NCBITaxon:superfamily -name: superfamily -namespace: ncbi_taxonomy -is_a: NCBITaxon:taxonomic_rank ! taxonomic rank - -[Term] -id: NCBITaxon:superkingdom -name: superkingdom -namespace: ncbi_taxonomy -is_a: NCBITaxon:taxonomic_rank ! taxonomic rank - -[Term] -id: NCBITaxon:superorder -name: superorder -namespace: ncbi_taxonomy -is_a: NCBITaxon:taxonomic_rank ! taxonomic rank - -[Term] -id: NCBITaxon:taxonomic_rank -name: taxonomic rank -namespace: ncbi_taxonomy -comment: This is an abstract class for use with the NCBI taxonomy to name the depth of the node within the tree. The link between the node term and the rank is only visible if you are using an obo 1.3 aware browser/editor; otherwise this can be ignored. - -[Term] -id: NCBITaxon:tribe -name: tribe -namespace: ncbi_taxonomy -is_a: NCBITaxon:taxonomic_rank ! taxonomic rank diff --git a/imports/ncbitaxon_import.owl b/imports/ncbitaxon_import.owl index 8fe86486a..57b1b407a 100644 --- a/imports/ncbitaxon_import.owl +++ b/imports/ncbitaxon_import.owl @@ -1,17 +1,16 @@ + xmlns:taxslim="http://purl.obolibrary.org/obo/ncbitaxon/subsets/taxslim#" + xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"> - - 2021-02-01 + + 2021-06-28 @@ -27,17 +26,9 @@ - + - - definition - - - - - - - + @@ -105,6 +96,24 @@ + + + + + + + + + + + + + + + + + + + + + + + NCBITaxon:27837 + GC_ID:1 + ncbi_taxonomy + Adenophorea + NCBITaxon:119089 + Chromadorea + + + + + Adenophorea + @@ -242,11 +278,24 @@ GC_ID:1 ncbi_taxonomy + NCBITaxon:1206794 Ecdysozoa + + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:1206795 + Lophotrochozoa + + + + @@ -254,13 +303,14 @@ GC_ID:1 ncbi_taxonomy biota + NCBITaxon:131567 cellular organisms biota - + @@ -271,6 +321,7 @@ GC_ID:1 ncbi_taxonomy + NCBITaxon:1338369 Dipnotetrapodomorpha @@ -280,7 +331,7 @@ - + GC_ID:1 PMID:11062127 PMID:9342353 @@ -288,25 +339,26 @@ Eumycetozoa Zopf, 1884 Mycetozoa mycetozoans + NCBITaxon:142796 Eumycetozoa - Mycetozoa - + Eumycetozoa Zopf, 1884 + - mycetozoans - + Mycetozoa + - Eumycetozoa Zopf, 1884 - + mycetozoans + @@ -320,13 +372,14 @@ PMID:11791233 ncbi_taxonomy Boreotheria + NCBITaxon:1437010 Boreoeutheria Boreotheria - + @@ -335,24 +388,25 @@ - + GC_ID:1 mice and others ncbi_taxonomy Sciurognathi + NCBITaxon:1963758 Myomorpha mice and others - + Sciurognathi - + @@ -361,38 +415,78 @@ - + GC_ID:1 ncbi_taxonomy Homo/Pan/Gorilla group + NCBITaxon:207598 Homininae Homo/Pan/Gorilla group - + + + + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:2301116 + Rhabditina + + + + + + + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:2301119 + Rhabditomorpha + + + + - + GC_ID:1 ncbi_taxonomy + NCBITaxon:2605435 Evosea + + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:2697495 + Spiralia + + + + - + GC_ID:1 PMID:23020233 PMID:30257078 @@ -404,64 +498,82 @@ Eukarya Eukaryotae eukaryotes + NCBITaxon:2759 Eukaryota eucaryotes - + eukaryotes - + Eucarya - + Eucaryotae - + Eukarya - + Eukaryotae - + eukaryotes - + + + + + + + GC_ID:1 + PMID:11214318 + PMID:11214319 + PMID:12878460 + ncbi_taxonomy + NCBITaxon:314145 + Laurasiatheria + + + + - + GC_ID:1 PMID:11214319 PMID:12082125 PMID:12878460 PMID:15522813 ncbi_taxonomy + NCBITaxon:314146 Euarchontoglires @@ -477,13 +589,14 @@ PMID:15522813 Rodents and rabbits ncbi_taxonomy + NCBITaxon:314147 Glires Rodents and rabbits - + @@ -492,17 +605,18 @@ - + GC_ID:1 ncbi_taxonomy Anthropoidea + NCBITaxon:314293 Simiiformes Anthropoidea - + @@ -511,24 +625,25 @@ - + GC_ID:1 ape apes ncbi_taxonomy + NCBITaxon:314295 Hominoidea ape - + apes - + @@ -540,13 +655,14 @@ GC_ID:1 tetrapods ncbi_taxonomy + NCBITaxon:32523 Tetrapoda tetrapods - + @@ -558,13 +674,14 @@ GC_ID:1 amniotes ncbi_taxonomy + NCBITaxon:32524 Amniota amniotes - + @@ -576,13 +693,14 @@ GC_ID:1 Theria ncbi_taxonomy + NCBITaxon:32525 Theria <mammals> Theria - + @@ -595,19 +713,20 @@ ncbi_taxonomy Fungi/Metazoa group opisthokonts + NCBITaxon:33154 Opisthokonta Fungi/Metazoa group - + opisthokonts - + @@ -616,38 +735,39 @@ - + GC_ID:1 metazoans multicellular animals ncbi_taxonomy Animalia animals + NCBITaxon:33208 Metazoa metazoans - + multicellular animals - + Animalia - + animals - + @@ -658,6 +778,7 @@ GC_ID:1 ncbi_taxonomy + NCBITaxon:33213 Bilateria @@ -669,6 +790,7 @@ GC_ID:1 ncbi_taxonomy + NCBITaxon:33317 Protostomia @@ -681,13 +803,41 @@ GC_ID:1 deuterostomes ncbi_taxonomy + NCBITaxon:33511 Deuterostomia deuterostomes - + + + + + + + + + + + GC_ID:1 + carnivores + ncbi_taxonomy + carnivores + NCBITaxon:33554 + Carnivora + + + + + carnivores + + + + + + carnivores + @@ -700,31 +850,60 @@ PMID:15019624 PMID:15371245 ncbi_taxonomy + NCBITaxon:337687 Muroidea + + + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:338152 + Felinae + + + + - + GC_ID:1 ncbi_taxonomy + NCBITaxon:376913 Haplorrhini + + + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:379583 + Feliformia + + + + - + NCBITaxon:109679 GC_ID:1 ncbi_taxonomy + NCBITaxon:39107 Murinae @@ -734,24 +913,25 @@ - + GC_ID:1 mammals ncbi_taxonomy mammals + NCBITaxon:40674 Mammalia mammals - + mammals - + @@ -760,32 +940,33 @@ - + GC_ID:1 PMID:11062127 PMID:12684019 ncbi_taxonomy Mycota fungi + NCBITaxon:4751 Fungi Mycota - + fungi - + fungi - + @@ -798,44 +979,203 @@ PMID:23020233 PMID:30257078 ncbi_taxonomy + NCBITaxon:554915 Amoebozoa + + + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:55879 + Rhabditoidea + + + + + + + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:55885 + Peloderinae + + + + GC_ID:1 ncbi_taxonomy + NCBITaxon:6072 Eumetazoa + + + + + + GC_ID:1 + flatworm + flatworms + ncbi_taxonomy + flatworms + NCBITaxon:6157 + Platyhelminthes + + + + + flatworm + + + + + + flatworms + + + + + + flatworms + + + + + + + + + + + GC_ID:1 + nematode + nematodes + roundworm + roundworms + ncbi_taxonomy + Nemata + nematodes + NCBITaxon:6231 + Nematoda + + + + + nematode + + + + + + nematodes + + + + + + roundworm + + + + + + roundworms + + + + + + Nemata + + + + + + nematodes + + + + + + + + + + + NCBITaxon:33251 + GC_ID:1 + ncbi_taxonomy + NCBITaxon:6236 + Rhabditida + + + + + + + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:6237 + Caenorhabditis + + + + + + + + + + NCBITaxon:54603 + GC_ID:1 + ncbi_taxonomy + NCBITaxon:6243 + Rhabditidae + + + + - + GC_ID:1 arthropods ncbi_taxonomy arthropods + NCBITaxon:6656 Arthropoda arthropods - + arthropods - + @@ -844,24 +1184,25 @@ - + GC_ID:1 chordates ncbi_taxonomy chordates + NCBITaxon:7711 Chordata chordates - + chordates - + @@ -875,25 +1216,26 @@ vertebrates ncbi_taxonomy vertebrates + NCBITaxon:7742 Vertebrata <vertebrates> Vertebrata - + vertebrates - + vertebrates - + @@ -906,19 +1248,20 @@ Gnathostomata jawed vertebrates ncbi_taxonomy + NCBITaxon:7776 Gnathostomata <vertebrates> Gnathostomata - + jawed vertebrates - + @@ -927,9 +1270,10 @@ - + GC_ID:1 ncbi_taxonomy + NCBITaxon:8287 Sarcopterygii @@ -939,17 +1283,18 @@ - + GC_ID:1 Mus ncbi_taxonomy + NCBITaxon:862507 Mus <subgenus> Mus - + @@ -960,6 +1305,7 @@ GC_ID:1 ncbi_taxonomy + NCBITaxon:88770 Panarthropoda @@ -969,17 +1315,18 @@ - + GC_ID:1 Craniata ncbi_taxonomy + NCBITaxon:89593 Craniata <chordates> Craniata - + @@ -995,37 +1342,38 @@ ncbi_taxonomy Placentalia placentals + NCBITaxon:9347 Eutheria eutherian mammals - + placental mammals - + placentals - + Placentalia - + placentals - + @@ -1034,31 +1382,32 @@ - + GC_ID:1 primate ncbi_taxonomy Primata primates + NCBITaxon:9443 Primates primate - + Primata - + primates - + @@ -1067,9 +1416,10 @@ - + GC_ID:1 ncbi_taxonomy + NCBITaxon:9526 Catarrhini @@ -1079,24 +1429,25 @@ - + GC_ID:1 great apes ncbi_taxonomy Pongidae + NCBITaxon:9604 Hominidae great apes - + Pongidae - + @@ -1105,17 +1456,18 @@ - + GC_ID:1 humans ncbi_taxonomy + NCBITaxon:9605 Homo humans - + @@ -1124,24 +1476,110 @@ - + GC_ID:1 human man ncbi_taxonomy + NCBITaxon:9606 Homo sapiens human - + man - + + + + + + + + + + + GC_ID:1 + cat family + ncbi_taxonomy + NCBITaxon:9681 + Felidae + + + + + cat family + + + + + + + + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:9682 + Felis + + + + + + + + + + NCBITaxon:36475 + GC_ID:1 + PMID:17600185 + PMID:8581300 + PMID:8603894 + cat + cats + domestic cat + ncbi_taxonomy + Felis domesticus + Felis silvestris catus + NCBITaxon:9685 + Felis catus + + + + + cat + + + + + + cats + + + + + + domestic cat + + + + + + Felis domesticus + + + + + + Felis silvestris catus + @@ -1150,24 +1588,25 @@ - + GC_ID:1 rodent ncbi_taxonomy rodents + NCBITaxon:9989 Rodentia rodent - + rodents - + diff --git a/imports/pato_import.owl b/imports/pato_import.owl index 7096099e6..7eb5e8153 100644 --- a/imports/pato_import.owl +++ b/imports/pato_import.owl @@ -8,18 +8,22 @@ xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:xml="http://www.w3.org/XML/1998/namespace" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" + xmlns:cito="http://purl.org/spar/cito/" + xmlns:core="http://purl.obolibrary.org/obo/uberon/core#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:pato="http://purl.obolibrary.org/obo/pato#" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" xmlns:swrl="http://www.w3.org/2003/11/swrl#" + xmlns:core1="http://purl.obolibrary.org/obo/core#" xmlns:swrla="http://swrl.stanford.edu/ontologies/3.3/swrla.owl#" xmlns:swrlb="http://www.w3.org/2003/11/swrlb#" xmlns:terms="http://purl.org/dc/terms/" xmlns:subsets="http://purl.obolibrary.org/obo/ro/subsets#" xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"> - - 2021-02-01 + + + 2021-06-28 @@ -92,6 +96,12 @@ + + + + + + @@ -124,6 +134,12 @@ + + + + + + @@ -136,6 +152,18 @@ + + + + + + + + + + + + @@ -192,6 +220,116 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + @@ -384,6 +522,153 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + uberon + dc-creator + true + dc-creator + creator + + + + @@ -408,6 +693,12 @@ + + + + + + @@ -430,6 +721,12 @@ + + + + + + @@ -442,6 +739,30 @@ + + + + + + + + + + + + + + + + + + + + + + + + @@ -498,6 +819,12 @@ + + + + + + @@ -512,58 +839,118 @@ - + - - shorthand - + - + - + - + - + - + - + - + - + - + + + shorthand + - + - - - - - is part of - my brain is part of my body (continuant parthood, two material entities) - my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity) + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + is part of + my brain is part of my body (continuant parthood, two material entities) + my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity) this day is part of this year (occurrent parthood) a core relation that holds between a part and its whole Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other. @@ -583,7 +970,12 @@ A continuant cannot be part of an occurrent: use 'participates in'. An BFO:0000050 external quality + uberon part_of + + + + part_of part of part of @@ -616,7 +1008,11 @@ A continuant cannot have an occurrent as part: use 'participates in'. BFO:0000051 external quality + uberon has_part + + + has_part We use the has_part relation to relate complex qualities to more primitive ones. A complex quality is a collection of qualities. The complex quality cannot exist without the sub-qualities. For example, the quality 'swollen' necessarily comes with the qualities of 'protruding' and 'increased size'. has part @@ -645,14 +1041,34 @@ A continuant cannot have an occurrent as part: use 'participates in'. preceded by + X preceded_by Y iff: end(Y) before_or_simultaneous_with start(X) x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. An example is: translation preceded_by transcription; aging preceded_by development (not however death preceded_by aging). Where derives_from links classes of continuants, preceded_by links classes of processes. Clearly, however, these two relations are not independent of each other. Thus if cells of type C1 derive_from cells of type C, then any cell division involving an instance of C1 in a given lineage is preceded_by cellular processes involving an instance of C. The assertion P preceded_by P1 tells us something about Ps in general: that is, it tells us something about what happened earlier, given what we know about what happened later. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be succeeded by some instance of P. Note that an assertion to the effect that P preceded_by P1 is rather weak; it tells us little about the relations between the underlying instances in virtue of which the preceded_by relation obtains. Typically we will be interested in stronger relations, for example in the relation immediately_preceded_by, or in relations which combine preceded_by with a condition to the effect that the corresponding instances of P and P1 share participants, or that their participants are connected by relations of derivation, or (as a first step along the road to a treatment of causality) that the one process in some way affects (for example, initiates or regulates) the other. is preceded by preceded_by http://www.obofoundry.org/ro/#OBO_REL:preceded_by + BFO:0000062 + is preceded by + takes place after + uberon + preceded_by + preceded_by preceded by + preceded_by + + + + is preceded by + SIO:000249 + + + + + takes place after + Allen:precedes + @@ -669,7 +1085,12 @@ A continuant cannot have an occurrent as part: use 'participates in'. precedes x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. + BFO:0000063 + uberon + precedes + precedes + precedes precedes @@ -694,6 +1115,9 @@ A continuant cannot have an occurrent as part: use 'participates in'. occurs_in unfolds in unfolds_in + + + Paraphrase of definition: a relation between a process and an independent continuant, in which the process takes place entirely within the independent continuant occurs in @@ -713,6 +1137,272 @@ A continuant cannot have an occurrent as part: use 'participates in'. + + + + + x anterior_to y iff x is further along the antero-posterior axis than y, towards the head. An antero-posterior axis is an axis that bisects an organism from head end to opposite end of body or tail: bearer + cjm + 2009-07-31T02:15:46Z + BSPO:0000096 + uberon + anterior_to + anterior_to + anterior_to + + + + + x anterior_to y iff x is further along the antero-posterior axis than y, towards the head. An antero-posterior axis is an axis that bisects an organism from head end to opposite end of body or tail: bearer + + + + + + + + + + + x dorsal_to y iff x is further along the dorso-ventral axis than y, towards the back. A dorso-ventral axis is an axis that bisects an organism from back (e.g. spinal column) to front (e.g. belly). + BSPO:0000098 + uberon + dorsal_to + dorsal_to + dorsal_to + + + + + x dorsal_to y iff x is further along the dorso-ventral axis than y, towards the back. A dorso-ventral axis is an axis that bisects an organism from back (e.g. spinal column) to front (e.g. belly). + + + + + + + + + + x posterior_to y iff x is further along the antero-posterior axis than y, towards the body/tail. An antero-posterior axis is an axis that bisects an organism from head end to opposite end of body or tail. + BSPO:0000099 + caudal_to + uberon + posterior_to + posterior_to + posterior_to + + + + + x posterior_to y iff x is further along the antero-posterior axis than y, towards the body/tail. An antero-posterior axis is an axis that bisects an organism from head end to opposite end of body or tail. + + + + + + + + + + x ventral_to y iff x is further along the dorso-ventral axis than y, towards the front. A dorso-ventral axis is an axis that bisects an organism from back (e.g. spinal column) to front (e.g. belly). + BSPO:0000102 + uberon + ventral_to + ventral_to + ventral_to + + + + + x ventral_to y iff x is further along the dorso-ventral axis than y, towards the front. A dorso-ventral axis is an axis that bisects an organism from back (e.g. spinal column) to front (e.g. belly). + + + + + + + + + + Further away from the surface of the organism. Thus, the muscular layer is deep to the skin, but superficial to the intestines. + BSPO:0000107 + uberon + deep_to + deep_to + deep_to + + + + + Further away from the surface of the organism. Thus, the muscular layer is deep to the skin, but superficial to the intestines. + + + + + + + + + Near the outer surface of the organism. Thus, skin is superficial to the muscle layer. + BSPO:0000108 + uberon + superficial_to + superficial_to + superficial_to + + + + + Near the outer surface of the organism. Thus, skin is superficial to the muscle layer. + + + + + + + + + + X posterior_side_of Y <=> if Y is subdivided into two anterior and posterior portions, X is part_of the posterior portion. + BSPO:0000122 + uberon + in_posterior_side_of + in_posterior_side_of + in_posterior_side_of + + + + + X posterior_side_of Y <=> if Y is subdivided into two anterior and posterior portions, X is part_of the posterior portion. + BSPO:PATO_mtg_2009 + + + + + + + + + X anterior_side_of Y <=> if Y is subdivided into two anterior and posterior portions, X is part_of the anterior portion. + BSPO:0000123 + uberon + in_anterior_side_of + in_anterior_side_of + in_anterior_side_of + + + + + X anterior_side_of Y <=> if Y is subdivided into two anterior and posterior portions, X is part_of the anterior portion. + BSPO:PATO_mtg_2009 + + + + + + + + + + X proximal_side_of Y <=> if Y is subdivided into distal and proximal portions, X is part_of the proximal portion. + BSPO:0000124 + uberon + in_proximal_side_of + in_proximal_side_of + in_proximal_side_of + + + + + X proximal_side_of Y <=> if Y is subdivided into distal and proximal portions, X is part_of the proximal portion. + BSPO:PATO_mtg_2009 + + + + + + + + + X distal_side_of Y <=> if Y is subdivided into distal and proximal portions, X is part_of the distal portion. + BSPO:0000125 + uberon + in_distal_side_of + in_distal_side_of + in_distal_side_of + + + + + X distal_side_of Y <=> if Y is subdivided into distal and proximal portions, X is part_of the distal portion. + BSPO:PATO_mtg_2009 + + + + + + + + + X in_lateral_side_of Y <=> if X is in_left_side_of Y or X is in_right_side_of Y. X is often, but not always a paired structure + BSPO:0000126 + uberon + in_lateral_side_of + in_lateral_side_of + in_lateral_side_of + https://github.com/obophenotype/uberon/wiki/Modeling-paired-structures-Design-Pattern + + + + + X in_lateral_side_of Y <=> if X is in_left_side_of Y or X is in_right_side_of Y. X is often, but not always a paired structure + + + + + + + + + + X proximalmost_part_of Y <=> X is part_of Y and X is adjacent_to the proximal boundary of Y + BSPO:0001106 + uberon + proximalmost_part_of + proximalmost_part_of + proximalmost_part_of + + + + + X proximalmost_part_of Y <=> X is part_of Y and X is adjacent_to the proximal boundary of Y + + + + + + + + + + + This relation holds when both the deep_to and ajdacent_to relationship similarly hold. + BSPO:0001107 + uberon + immediately_deep_to + immediately_deep_to + immediately_deep_to + + + + + This relation holds when both the deep_to and ajdacent_to relationship similarly hold. + + + + + @@ -742,6 +1432,11 @@ A continuant cannot have an occurrent as part: use 'participates in'. bearer_of is bearer of + RO:0000053 + uberon + bearer_of + bearer_of + bearer of bearer of @@ -786,6 +1481,79 @@ A continuant cannot have an occurrent as part: use 'participates in'. + + + + RO:0001015 + uberon + location_of + location_of + location_of + + + + + + + + RO:0001019 + uberon + contains + contains + contains + + + + + + + + RO:0001025 + uberon + located_in + located_in + located_in + + + + + + + + RO:0002002 + uberon + has_boundary + has_boundary + has boundary + + + + + + + + + + David Osumi-Sutherland + has synaptic terminal of + + + + + + + + + RO:0002007 + uberon + bounding_layer_of + bounding_layer_of + A relationship that applies between a continuant and its outer, bounding layer. Examples include the relationship between a multicellular organism and its integument, between an animal cell and its plasma membrane, and between a membrane bound organelle and its outer/bounding membrane. + bounding layer of + + + + @@ -914,7 +1682,6 @@ A continuant cannot have an occurrent as part: use 'participates in'. - A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity. dos @@ -949,11 +1716,35 @@ A continuant cannot have an occurrent as part: use 'participates in'. + X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y) David Osumi-Sutherland starts_at_end_of + A non-transitive temporal relation in which one process immediately precedes another process, such that there is no interval of time between the two processes[SIO:000251]. + RO:0002087 + directly preceded by + is directly preceded by + is immediately preceded by + starts_at_end_of + uberon + immediately_preceded_by + immediately_preceded_by X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y) immediately preceded by + immediately_preceded_by + + + + + A non-transitive temporal relation in which one process immediately precedes another process, such that there is no interval of time between the two processes[SIO:000251]. + SIO:000251 + + + + + is immediately preceded by + SIO:000251 + @@ -972,46 +1763,257 @@ A continuant cannot have an occurrent as part: use 'participates in'. - + - - - - - - + + + + - + + + Relation between a neuron and an anatomical structure that its soma is part of. + David Osumi-Sutherland + <http://purl.obolibrary.org/obo/BFO_0000051> some ( + <http://purl.obolibrary.org/obo/GO_0043025> and <http://purl.obolibrary.org/obo/BFO_0000050> some ?Y) + + has soma location + + + + + + + + + - - - - - + - x overlaps y if and only if there exists some z such that x has part z and z part of y - http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.obolibrary.org/obo/BFO_0000050 some ?Y) + Relation between a neuron and some structure its axon forms (chemical) synapses in. + Chris Mungall + David Osumi-Sutherland + David Osumi-Sutherland + <http://purl.obolibrary.org/obo/BFO_0000051> some ( + <http://purl.obolibrary.org/obo/GO_0030424> and <http://purl.obolibrary.org/obo/BFO_0000051> some ( + <http://purl.obolibrary.org/obo/GO_0042734> and <http://purl.obolibrary.org/obo/BFO_0000050> some ( + <http://purl.obolibrary.org/obo/GO_0045202> and <http://purl.obolibrary.org/obo/BFO_0000050> some ?Y))) - - overlaps + + axon synapses in - - - - - - - - true - - + + + + + + + + + + + + Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input. + Chris Mungall + David Osumi-Sutherland + synapsed in + http://purl.obolibrary.org/obo/BFO_0000051 some ( + http://purl.org/obo/owl/GO#GO_0045211 and http://purl.obolibrary.org/obo/BFO_0000050 some ( + http://purl.org/obo/owl/GO#GO_0045202 and http://purl.obolibrary.org/obo/BFO_0000050 some ?Y)) + + + has postsynaptic terminal in + + + + + + + + + + + + + + + Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input. + synapses in + <http://purl.obolibrary.org/obo/BFO_0000051> some (<http://purl.obolibrary.org/obo/GO_0042734> that <http://purl.obolibrary.org/obo/BFO_0000050> some (<http://purl.obolibrary.org/obo/GO_0045202> that <http://purl.obolibrary.org/obo/BFO_0000050> some Y?) + + + has presynaptic terminal in + + + + + + + + + + + + + + + A general relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input. + David Osumi-Sutherland + has synapse in + <http://purl.obolibrary.org/obo/RO_0002131> some (<http://purl.obolibrary.org/obo/GO_0045202> that <http://purl.obolibrary.org/obo/BFO_0000050> some Y?) + + + has synaptic terminal in + + + + + + + + + + + + + + + + + + + + + + + + + + x overlaps y if and only if there exists some z such that x has part z and z part of y + http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.obolibrary.org/obo/BFO_0000050 some ?Y) + + + + + overlaps + + + + + + + + + true + + + + + + + + + RO:0002150 + uberon + continuous_with + continuous_with + continuous_with + + + + + + + + + Binary relationship: x connected_to y if and only if there exists some z such that z connects x and y in a ternary connected_to(x,y,z) relationship. + RO:0002170 + uberon + connected_to + connected_to + Connection does not imply overlaps. + connected to + + + + + + Binary relationship: x connected_to y if and only if there exists some z such that z connects x and y in a ternary connected_to(x,y,z) relationship. + + + + + + + + + Binary relationship: z connects x if and only if there exists some y such that z connects x and y in a ternary connected_to(x,y,z) relationship. + this is currently used for both structural relationships (such as between a valve and the chamber it connects) and abstract relationships (anatomical lines and the entities they connect) + RO:0002176 + uberon + connects + connects + connects + + + + + Binary relationship: z connects x if and only if there exists some y such that z connects x and y in a ternary connected_to(x,y,z) relationship. + + + + + + + + + + + + + RO:0002177 + uberon + attaches_to_part_of + attaches_to_part_of + attaches_to_part_of + + + + + + + + + true + + + + + + + + + + RO:0002179 + drains blood from + drains from + uberon + drains + drains + source: Wikipedia + drains + + + + + @@ -1020,7 +2022,12 @@ A continuant cannot have an occurrent as part: use 'participates in'. The definition of 'has component' is still under discussion. The challenge is in providing a definition that does not imply transitivity. For use in recording has_part with a cardinality constraint, because OWL does not permit cardinality constraints to be used in combination with transitive object properties. In situations where you would want to say something like 'has part exactly 5 digit, you would instead use has_component exactly 5 digit. + RO:0002180 + uberon + has_component + has_component + has component has component @@ -1030,19 +2037,33 @@ A continuant cannot have an occurrent as part: use 'participates in'. + + + + + + + + + x develops from y if and only if either (a) x directly develops from y or (b) there exists some z such that x directly develops from z and z develops from y Chris Mungall David Osumi-Sutherland Melissa Haendel Terry Meehan + RO:0002202 + uberon + develops_from + develops_from This is the transitive form of the develops from relation develops from + develops_from @@ -1059,8 +2080,13 @@ A continuant cannot have an occurrent as part: use 'participates in'. Chris Mungall David Osumi-Sutherland Terry Meehan + RO:0002203 + uberon + develops_into + develops_into develops into + develops_into @@ -1073,6 +2099,10 @@ A continuant cannot have an occurrent as part: use 'participates in'. + + + + @@ -1088,6 +2118,9 @@ A continuant cannot have an occurrent as part: use 'participates in'. Regulation precludes parthood; the regulatory process may not be within the regulated process. regulates (processual) false + + + regulates @@ -1104,6 +2137,9 @@ A continuant cannot have an occurrent as part: use 'participates in'. negatively regulates (process to process) + + + negatively regulates @@ -1125,6 +2161,9 @@ A continuant cannot have an occurrent as part: use 'participates in'. positively regulates (process to process) + + + positively regulates @@ -1144,7 +2183,6 @@ A continuant cannot have an occurrent as part: use 'participates in'. For compatibility with BFO, this relation has a shortcut definition in which the expression "capable of some P" expands to "bearer_of (some realized_by only P)". - RO_0000053 some (RO_0000054 only ?Y) capable of @@ -1163,7 +2201,6 @@ A continuant cannot have an occurrent as part: use 'participates in'. c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p. Chris Mungall has function in - RO_0000053 some (RO_0000054 only (BFO_0000050 some ?Y)) capable of part of @@ -1179,6 +2216,59 @@ A continuant cannot have an occurrent as part: use 'participates in'. + + + + + x surrounded_by y iff: x is adjacent to y and for every region r adjacent to x, r overlaps y + RO:0002219 + uberon + surrounded_by + surrounded_by + surrounded_by + + + + + x surrounded_by y iff: x is adjacent to y and for every region r adjacent to x, r overlaps y + + + + + + + + + + x adjacent_to y iff: x and y share a boundary + RO:0002220 + uberon + adjacent_to + adjacent_to + adjacent_to + + + + + + + + inverse of surrounded_by + RO:0002221 + uberon + surrounds + surrounds + surrounds + + + + + inverse of surrounded_by + + + + + @@ -1196,17 +2286,92 @@ A continuant cannot have an occurrent as part: use 'participates in'. + + + + + + Relation between occurrents, shares a start boundary with. + RO:0002223 + uberon + starts + starts + starts + + + + + Relation between occurrents, shares a start boundary with. + + Allen:starts + + + + + + + + + + RO:0002224 + uberon + starts_with + starts_with + starts with + + + + + + + + + Relation between occurrents, shares an end boundary with. + RO:0002229 + finishes + uberon + ends + ends + ends + + + + + Relation between occurrents, shares an end boundary with. + + Allen:starts + ZFS:finishes + + + + + + + + + + RO:0002230 + uberon + ends_with + ends_with + ends with + + + + - p has input c iff: p is a process, c is a material entity, c is a participant in p, c is present at the start of p, and the state of c is modified during p. Chris Mungall consumes + + + has input @@ -1218,6 +2383,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. + @@ -1228,6 +2394,11 @@ A continuant cannot have an occurrent as part: use 'participates in'. x has developmental contribution from y iff x has some part z such that z develops from y Chris Mungall + RO:0002254 + uberon + has_developmental_contribution_from + has_developmental_contribution_from + has developmental contribution from has developmental contribution from @@ -1245,9 +2416,34 @@ A continuant cannot have an occurrent as part: use 'participates in'. inverse of has developmental contribution from Chris Mungall + RO:0002255 + uberon + developmentally_contributes_to + developmentally_contributes_to developmentally contributes to + developmentally_contributes_to + + + + + + + + t1 developmentally_induced_by t2 if there is a process of organ induction (GO:0001759) with t1 and t2 as interacting participants. t2 causes t1 to change its fate from a precursor tissue type T to T', where T' develops_from T. + RO:0002256 + uberon + developmentally_induced_by + developmentally_induced_by + sources for developmentally_induced_by relationships in Uberon: Developmental Biology, Gilbert, 8th edition, figure 6.5(F) + developmentally_induced_by + + + + t1 developmentally_induced_by t2 if there is a process of organ induction (GO:0001759) with t1 and t2 as interacting participants. t2 causes t1 to change its fate from a precursor tissue type T to T', where T' develops_from T. + GO:0001759 + @@ -1279,6 +2475,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. A faulty traffic light (material entity) whose malfunctioning (a process) is causally upstream of a traffic collision (a process): the traffic light acts upstream of the collision. c acts upstream of p if and only if c enables some f that is involved in p' and p' occurs chronologically before p, is not part of p, and affects the execution of p. c is a material entity and f, p, p' are processes. + acts upstream of @@ -1296,12 +2493,25 @@ A continuant cannot have an occurrent as part: use 'participates in'. A gene product that has some activity, where that activity may be a part of a pathway or upstream of the pathway. c acts upstream of or within p if c is enables f, and f is causally upstream of or within p. c is a material entity and p is an process. affects + acts upstream of or within + + + + RO:0002285 + uberon + developmentally_replaces + developmentally_replaces + developmentally_replaces + + + + @@ -1321,6 +2531,8 @@ A continuant cannot have an occurrent as part: use 'participates in'. cjm + + holds between x and y if and only if x is causally upstream of y and the progression of x increases the frequency, rate or extent of y causally upstream of, positive effect @@ -1417,6 +2629,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. is executing This relation differs from the parent relation 'capable of' in that the parent is weaker and only expresses a capability that may not be actually realized, whereas this relation is always realized. This relation is currently used experimentally by the Gene Ontology Consortium. It may not be stable and may be obsoleted at some future time. + enables @@ -1488,6 +2701,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. inverse of enables Chris Mungall + enabled by @@ -1533,6 +2747,33 @@ A continuant cannot have an occurrent as part: use 'participates in'. + + + + + + RO:0002350 + uberon + member_of + member_of + member of + + + + + + + + + RO:0002351 + uberon + has_member + has_member + has member + + + + @@ -1547,6 +2788,56 @@ A continuant cannot have an occurrent as part: use 'participates in'. + + + + + + RO:0002371 + uberon + attaches_to + attaches_to + attaches_to + + + + + + + + + RO:0002376 + uberon + drains into + tributary_of + tributary_of + tributary_of + + + + + drains into + dbpowl:drainsTo + + + + + + + + + + we need to check if FMA branch_of implies part_of. the relation we intend to use here should - for example, see vestibulocochlear nerve + RO:0002380 + uberon + branching_part_of + branching_part_of + branching_part_of + + + + + @@ -1566,8 +2857,14 @@ A continuant cannot have an occurrent as part: use 'participates in'. + x has potential to developmentrally contribute to y iff x developmentally contributes to y or x is capable of developmentally contributing to y x has potential to developmentrally contribute to y iff x developmentally contributes to y or x is capable of developmentally contributing to y Chris Mungall + RO:0002385 + uberon + has_potential_to_developmentally_contribute_to + has_potential_to_developmentally_contribute_to + has potential to developmentally contribute to has potential to developmentally contribute to @@ -1578,8 +2875,14 @@ A continuant cannot have an occurrent as part: use 'participates in'. + x has the potential to develop into y iff x develops into y or if x is capable of developing into y x has the potential to develop into y iff x develops into y or if x is capable of developing into y Chris Mungall + RO:0002387 + uberon + has_potential_to_develop_into + has_potential_to_develop_into + has potential to develop into has potential to develop into @@ -1660,6 +2963,8 @@ Each of these 3 primitives can be composed to yield a cross-product of different p is causally upstream of q if and only if p precedes q and p and q are linked in a causal chain Chris Mungall + + causally upstream of @@ -1820,6 +3125,18 @@ Each of these 3 primitives can be composed to yield a cross-product of different + + + + RO:0002433 + uberon + contributes_to_morphology_of + contributes_to_morphology_of + contributes to morphology of + + + + @@ -1945,6 +3262,21 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + x composed_primarily_of y iff: more than half of the mass of x is made from parts of y + RO:0002473 + uberon + RO:0002473 + composed_primarily_of + composed_primarily_of + composed primarily of + + + + @@ -1981,29 +3313,233 @@ For example, A and B may be gene products and binding of B by A positively regul - + - - - - A relationship between a material entity and a process where the material entity has some causal role that influences the process - - causal agent in process + + + + + + + Relation between continuant c and occurrent s, such that every instance of c comes into existing during some s. + RO:0002488 + begins_to_exist_during + uberon + RO:0002488 + existence_starts_during + existence_starts_during + existence starts during + + + + Relation between continuant c and occurrent s, such that every instance of c comes into existing during some s. + + - + - - - - - p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one of direct activation or direct inhibition. p may be upstream, downstream, part of or a container of q. - Chris Mungall - - Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect. - causal relation between processes + + + Relation between continuant and occurrent, such that c comes into existence at the start of p. + RO:0002489 + uberon + existence_starts_with + existence_starts_with + existence starts with + + + + + Relation between continuant and occurrent, such that c comes into existence at the start of p. + + + + + + + + + + + RO:0002491 + uberon + existence_starts_and_ends_during + existence_starts_and_ends_during + existence starts and ends during + + + + + + + + + + + + + Relation between continuant c and occurrent s, such that every instance of c ceases to exist during some s, if it does not die prematurely. + RO:0002492 + ceases_to_exist_during + uberon + RO:0002492 + existence_ends_during + existence_ends_during + existence ends during + + + + + Relation between continuant c and occurrent s, such that every instance of c ceases to exist during some s, if it does not die prematurely. + + + + + + + + + + Relation between continuant and occurrent, such that c ceases to exist at the end of p. + RO:0002493 + uberon + existence_ends_with + existence_ends_with + existence ends with + + + + + Relation between continuant and occurrent, such that c ceases to exist at the end of p. + + + + + + + + + + + RO:0002494 + transforms from + uberon + transformation_of + transformation_of + transformation of + + + + + + transforms from + SIO:000657 + + + + + + + + + RO:0002495 + direct_transformation_of + immediately transforms from + uberon + immediate_transformation_of + immediate_transformation_of + immediate transformation of + + + + + + direct_transformation_of + + + + + + immediately transforms from + SIO:000658 + + + + + + + + + + + + + + + + + + + + RO:0002496 + uberon + existence_starts_during_or_after + existence_starts_during_or_after + existence starts during or after + + + + + + + + + + + + + + + + + + + + RO:0002497 + uberon + existence_ends_during_or_before + existence_ends_during_or_before + existence ends during or before + + + + + + + + + + A relationship between a material entity and a process where the material entity has some causal role that influences the process + + causal agent in process + + + + + + + + + + + p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one of direct activation or direct inhibition. p may be upstream, downstream, part of or a container of q. + Chris Mungall + + Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect. + causal relation between processes @@ -2033,6 +3569,31 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + + + + A relation between a subdivision of an organism and the single subdivision of skeleton that provides structural support for that subdivision. + RO:0002551 + uberon + has sekeletal support + has supporting framework + has_skeleton + has_skeleton + has skeleton + + + + + A relation between a subdivision of an organism and the single subdivision of skeleton that provides structural support for that subdivision. + + + + + @@ -2094,6 +3655,45 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + RO:0002569 + uberon + has_branching_part + has_branching_part + has branching part + + + + + + + + + RO:0002572 + uberon + luminal_space_of + luminal_space_of + luminal space of + + + + + + + + + RO:0002576 + uberon + skeleton_of + skeleton_of + skeleton of + + + + @@ -2104,6 +3704,9 @@ For example, A and B may be gene products and binding of B by A positively regul directly regulates (processual) + + + directly regulates @@ -2208,6 +3811,9 @@ For example, A and B may be gene products and binding of B by A positively regul directly positively regulates (process to process) + + + directly positively regulates @@ -2222,11 +3828,38 @@ For example, A and B may be gene products and binding of B by A positively regul directly negatively regulates (process to process) + + + directly negatively regulates + + + + RO:0003000 + uberon + produces + produces + produces + + + + + + + + RO:0003001 + uberon + produced_by + produced_by + produced_by + + + + @@ -2254,6 +3887,7 @@ For example, A and B may be gene products and binding of B by A positively regul cjm 2018-01-26T23:49:30Z + acts upstream of or within, positive effect @@ -2271,6 +3905,7 @@ For example, A and B may be gene products and binding of B by A positively regul cjm 2018-01-26T23:49:51Z + acts upstream of or within, negative effect @@ -2289,6 +3924,7 @@ For example, A and B may be gene products and binding of B by A positively regul cjm 2018-01-26T23:53:14Z + acts upstream of, positive effect @@ -2308,6 +3944,7 @@ For example, A and B may be gene products and binding of B by A positively regul cjm 2018-01-26T23:53:22Z + acts upstream of, negative effect @@ -2442,6 +4079,142 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + + + x anteriorly_connected_to y iff the anterior part of x is connected to y. i.e. x connected_to y and x posterior_to y. + uberon + anteriorly_connected_to + anteriorly connected to + + + + + x anteriorly_connected_to y iff the anterior part of x is connected to y. i.e. x connected_to y and x posterior_to y. + + + + + + + + + + + carries + uberon + channel_for + channel for + + + + + + + + + uberon + channels_from + channels_from + + + + + + + + x is a conduit for y iff y passes through the lumen of x. + uberon + conduit_for + conduit for + + + + + + + + Relationship between a fluid and a material entity, where the fluid is the output of a realization of a filtration role that inheres in the material entity. + uberon + filtered_through + Relationship between a fluid and a filtration barrier, where the portion of fluid arises as a transformation of another portion of fluid on the other side of the barrier, with larger particles removed + filtered through + + + + + + + + + + x posteriorly_connected_to y iff the posterior part of x is connected to y. i.e. x connected_to y and x anterior_to y. + uberon + posteriorly_connected_to + posteriorly connected to + + + + + x posteriorly_connected_to y iff the posterior part of x is connected to y. i.e. x connected_to y and x anterior_to y. + + + + + + + + + uberon + protects + protects + + + + + + + + uberon + subdivision_of + placeholder relation. X = 'subdivision of A' and subdivision_of some B means that X is the mereological sum of A and B + subdivision of + + + + + + + + + . + uberon + transitively_anteriorly_connected_to + transitively anteriorly connected to + + + + + . + + + + + + + + + + uberon + transitively_connected_to + transitively_connected to + + + + + + + + + neuron + + + + @@ -2674,10 +4457,12 @@ For example, A and B may be gene products and binding of B by A positively regul - - The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. + + A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm. + https://github.com/geneontology/go-ontology/issues/17776 Wikipedia:Intracellular internal to cell + intracellular protoplasm cellular_component nucleocytoplasm @@ -2688,12 +4473,12 @@ For example, A and B may be gene products and binding of B by A positively regul - intracellular + intracellular anatomical structure - The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. + A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm. ISBN:0198506732 @@ -2751,73 +4536,178 @@ For example, A and B may be gene products and binding of B by A positively regul horsetail nucleus GOC:al GOC:mah - GOC:vw + GOC:vw PMID:15030757 - + - - + + - + - The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. - GO:0005904 - juxtamembrane - NIF_Subcellular:sao1663586795 - Wikipedia:Cell_membrane - cell membrane - cellular membrane - cytoplasmic membrane - plasmalemma - bacterial inner membrane - inner endospore membrane - plasma membrane lipid bilayer + + + + + + + The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). + GO:0005636 + Wikipedia:Nuclear_envelope cellular_component - GO:0005886 - - - + GO:0005635 - - - - - plasma membrane + nuclear envelope - + - The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. - ISBN:0716731363 - - - - - cellular membrane - NIF_Subcellular:sao6433132645 - - - - - plasma membrane lipid bilayer - GOC:mah + The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). + ISBN:0198547684 - + - - + + + + + + + + + All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. + Wikipedia:Cytoplasm + cellular_component + GO:0005737 + + + + + + + + cytoplasm + + + + + All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. + ISBN:0198547684 + + + + + + + + + + + + + + + A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. + Wikipedia:Vacuole + cellular_component + vacuolar carboxypeptidase Y + GO:0005773 + + + + + + + + + + + + vacuole + + + + + A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. + GOC:mtg_sensu + ISBN:0198506732 + + + + + + + + + + + + + + + The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. + GO:0005904 + juxtamembrane + NIF_Subcellular:sao1663586795 + Wikipedia:Cell_membrane + cell membrane + cellular membrane + cytoplasmic membrane + plasmalemma + bacterial inner membrane + inner endospore membrane + plasma membrane lipid bilayer + cellular_component + GO:0005886 + + + + + + + + + + + plasma membrane + + + + + The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. + ISBN:0716731363 + + + + + cellular membrane + NIF_Subcellular:sao6433132645 + + + + + plasma membrane lipid bilayer + GOC:mah + + + + + + + + @@ -2856,7 +4746,7 @@ For example, A and B may be gene products and binding of B by A positively regul GOC:cilia GOC:curators GOC:kmv - GOC:vw + GOC:vw ISBN:0198547684 PMID:16824949 PMID:17009929 @@ -2865,6 +4755,48 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + + + + + + + + + + + + + + + + + + The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. + Wikipedia:Cell_cortex + cellular_component + cell periphery + peripheral cytoplasm + GO:0005938 + + + + cell cortex + + + + + The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. + GOC:mah + ISBN:0815316194 + + + + @@ -2903,12 +4835,53 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + + + + + + + + + + + + + A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. + Wikipedia:Endomembrane_system + cellular_component + GO:0012505 + + + + + endomembrane system + + + + + A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. + GOC:lh + + + + A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. + 2014-03-06T11:37:54Z + GO:0098589 + GO:0098805 Wikipedia:Biological_membrane + membrane region + region of membrane + whole membrane cellular_component GO:0016020 @@ -2992,72 +4965,240 @@ For example, A and B may be gene products and binding of B by A positively regul - + - - - A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. - GO:0043234 - macromolecular complex - macromolecule complex - protein containing complex - protein complex - protein-protein complex + + + + + + + + + + + + + + + + + + + + A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle. + NIF_Subcellular:sao830981606 cellular_component - GO:0032991 - - - - - - A protein complex in this context is meant as a stable set of interacting proteins which can be co-purified by an acceptable method, and where the complex has been shown to exist as an isolated, functional unit in vivo. Acceptable experimental methods include stringent protein purification followed by detection of protein interaction. The following methods should be considered non-acceptable: simple immunoprecipitation, pull-down experiments from cell extracts without further purification, colocalization and 2-hybrid screening. Interactions that should not be captured as protein complexes include: 1) enzyme/substrate, receptor/ligand or any similar transient interactions, unless these are a critical part of the complex assembly or are required e.g. for the receptor to be functional; 2) proteins associated in a pull-down/co-immunoprecipitation assay with no functional link or any evidence that this is a defined biological entity rather than a loose-affinity complex; 3) any complex where the only evidence is based on genetic interaction data; 4) partial complexes, where some subunits (e.g. transmembrane ones) cannot be expressed as recombinant proteins and are excluded from experiments (in this case, independent evidence is necessary to find out the composition of the full complex, if known). Interactions that may be captured as protein complexes include: 1) enzyme/substrate or receptor/ligand if the complex can only assemble and become functional in the presence of both classes of subunits; 2) complexes where one of the members has not been shown to be physically linked to the other(s), but is a homologue of, and has the same functionality as, a protein that has been experimentally demonstrated to form a complex with the other member(s); 3) complexes whose existence is accepted based on localization and pharmacological studies, but for which experimental evidence is not yet available for the complex as a whole. - protein-containing complex + intracellular membrane + GO:0031090 + organelle membrane - + - A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. + A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle. GOC:dos GOC:mah + + + + intracellular membrane + NIF_Subcellular:sao830981606 + - + - - - A prolongation or process extending from a cell, e.g. a flagellum or axon. - cell process - cellular process - cellular projection + + + + + + + + + + + + + + + + + + + + Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. + NIF_Subcellular:sao1687101204 cellular_component - GO:0042995 - - - - - cell projection + GO:0031965 + nuclear membrane - + - A prolongation or process extending from a cell, e.g. a flagellum or axon. - GOC:jl - http://www.cogsci.princeton.edu/~wn/ + Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. + GOC:mah + GOC:pz - + - - - Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane. - NIF_Subcellular:sao1539965131 - Wikipedia:Organelle + + + + + + + + + + + + + + + A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes. cellular_component - GO:0043226 + GO:0031967 + + organelle envelope + + + + + A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes. + GOC:mah + GOC:pz + + + + + + + + + A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers. + cellular_component + GO:0031975 + envelope + + + + + A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers. + GOC:mah + GOC:pz + + + + + + + + + + + + + + + + + + + + + + + + + + All of the contents of a plasma membrane bounded cell projection, excluding the plasma membrane surrounding the projection. + cellular_component + GO:0032838 + plasma membrane bounded cell projection cytoplasm + + + + + All of the contents of a plasma membrane bounded cell projection, excluding the plasma membrane surrounding the projection. + GOC:krc + GOC:mah + + + + + + + + + A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. + GO:0043234 + macromolecular complex + macromolecule complex + protein containing complex + protein complex + protein-protein complex + cellular_component + GO:0032991 + + + + + + A protein complex in this context is meant as a stable set of interacting proteins which can be co-purified by an acceptable method, and where the complex has been shown to exist as an isolated, functional unit in vivo. Acceptable experimental methods include stringent protein purification followed by detection of protein interaction. The following methods should be considered non-acceptable: simple immunoprecipitation, pull-down experiments from cell extracts without further purification, colocalization and 2-hybrid screening. Interactions that should not be captured as protein complexes include: 1) enzyme/substrate, receptor/ligand or any similar transient interactions, unless these are a critical part of the complex assembly or are required e.g. for the receptor to be functional; 2) proteins associated in a pull-down/co-immunoprecipitation assay with no functional link or any evidence that this is a defined biological entity rather than a loose-affinity complex; 3) any complex where the only evidence is based on genetic interaction data; 4) partial complexes, where some subunits (e.g. transmembrane ones) cannot be expressed as recombinant proteins and are excluded from experiments (in this case, independent evidence is necessary to find out the composition of the full complex, if known). Interactions that may be captured as protein complexes include: 1) enzyme/substrate or receptor/ligand if the complex can only assemble and become functional in the presence of both classes of subunits; 2) complexes where one of the members has not been shown to be physically linked to the other(s), but is a homologue of, and has the same functionality as, a protein that has been experimentally demonstrated to form a complex with the other member(s); 3) complexes whose existence is accepted based on localization and pharmacological studies, but for which experimental evidence is not yet available for the complex as a whole. + protein-containing complex + + + + + A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. + GOC:dos + GOC:mah + + + + + + + + + A prolongation or process extending from a cell, e.g. a flagellum or axon. + cell process + cellular process + cellular projection + cellular_component + GO:0042995 + + + + + cell projection + + + + + A prolongation or process extending from a cell, e.g. a flagellum or axon. + GOC:jl + http://www.cogsci.princeton.edu/~wn/ + + + + + + + + + Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane. + NIF_Subcellular:sao1539965131 + Wikipedia:Organelle + cellular_component + GO:0043226 @@ -3075,7 +5216,24 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + + + + + + + + + + + + + Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. NIF_Subcellular:sao414196390 membrane-enclosed organelle @@ -3131,6 +5289,17 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + + + + + + + Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. @@ -3180,6 +5349,55 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + + + + + + + + + + + + + + + + + + All of the contents of a cilium, excluding the plasma membrane surrounding the cilium. + pr + 2011-03-23T01:52:31Z + cilium plasm + microtubule-based flagellar matrix + microtubule-based flagellum matrix + cellular_component + cilial cytoplasm + ciliary cytoplasm + cilium cytoplasm + microtubule-based flagellar cytoplasm + microtubule-based flagellum cytoplasm + GO:0097014 + Note that we deem cilium and microtubule-based flagellum to be equivalent. Also, researchers consider the composition of both the plasm and the membrane of the cilium to be detectably different from that in the non-ciliary cytosol and plasma membrane (e.g. in terms of calcium ion concentration, membrane lipid composition, and more). For this reason, the term "ciliary plasm" is not linked to "cytoplasm". + ciliary plasm + + + + + All of the contents of a cilium, excluding the plasma membrane surrounding the cilium. + GOC:BHF + GOC:cilia + GOC:dos + PMID:17895364 + + + + @@ -3291,6 +5509,78 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + + + + + + + + + + + + + + + + + + Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm. + cellular_component + GO:0099568 + cytoplasmic region + + + + + Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm. + GOC:dos + + + + + + + + + + + + + + + + + + + + + + + + + + + The complete extent of cell cortex that underlies some some region of the plasma membrane. + perimembrane region + cellular_component + GO:0099738 + cell cortex region + + + + + The complete extent of cell cortex that underlies some some region of the plasma membrane. + GOC:dos + + + + @@ -3333,6 +5623,7 @@ For example, A and B may be gene products and binding of B by A positively regul A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon. + https://github.com/geneontology/go-ontology/issues/13193 krc 2017-03-21T17:26:07Z cellular_component @@ -3348,6 +5639,45 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + + + + + + + + + + + + + + + + + + A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus. + pg + 2020-09-09T05:12:38Z + nuclear complex + cellular_component + GO:0140513 + + nuclear protein-containing complex + + + + + A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus. + GOC:pg + + + + @@ -3503,7 +5833,7 @@ For example, A and B may be gene products and binding of B by A positively regul conformation - VT:1000738 + VT:1000738 @@ -3808,7 +6138,7 @@ For example, A and B may be gene products and binding of B by A positively regul A cellular quality inhering in a bearer by virtue of the bearer's number of homologous sets of chromosomes in the nucleus or primary chromosome-containing compartment of the cell, each set essentially coding for all the biological traits of the organism. - Wikipedia:http://en.wikipedia.org/wiki/Ploidy + Wikipedia:http://en.wikipedia.org/wiki/Ploidy @@ -3828,7 +6158,7 @@ For example, A and B may be gene products and binding of B by A positively regul A ploidy quality inhering in a bearer by virtue of the bearer's containing a single set of homologous chromosomes. - Wikipedia:http://en.wikipedia.org/wiki/Haploid + Wikipedia:http://en.wikipedia.org/wiki/Haploid @@ -4423,6 +6753,26 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + A shape quality inhering in a bearer by virtue of the bearer's being partly divided into a determinate number of regions. + quality + PATO:0001979 + + + lobed + + + + + A shape quality inhering in a bearer by virtue of the bearer's being partly divided into a determinate number of regions. + ISBN:0881923214 + + + + @@ -4796,7 +7146,7 @@ For example, A and B may be gene products and binding of B by A positively regul A shape that inheres in a 3 dimensional entity. - PATOC:OREGON + PATOC:OREGON @@ -5048,146 +7398,58303 @@ For example, A and B may be gene products and binding of B by A positively regul A surface feature shape quality inhering in a bearer by virtue of the bearer's not having undulating edges forming lobes. - PATOC:DOS + PATOC:DOS - + - - + + + A quality of a single cell inhering in the bearer by virtue of the bearer's size or shape or structure. + http://orcid.org/0000-0002-7073-9172 + 2021-01-23T11:31:53Z + quality + PATO:0010006 + Use this term for morphologies that can *only* inhere in a cell, e.g. morphological qualities inhering in a cell by virtue of the presence, location or shape of one or more cell parts. + cell morphology + + + + + A quality of a single cell inhering in the bearer by virtue of the bearer's size or shape or structure. + ORCID:0000-0002-7073-9172 + + + + + + + + + + + + + + + + + + + + + + + + + + A quality of an object that has a value that is normal or average. + Luke Slater + 2017-12-21T14:11:01Z + quality + PATO:0045001 + normal object quality + + + + + + + + + + + + + + + + + + + + + An affinity which is relatively normal or average. + Luke Slater + 2017-12-22T14:16:43Z + quality + PATO:0045004 + + normal affinity + + + + + + + + + + + + + + + + + + + + + A curvature which is relatively normal or average. + Luke Slater + 2017-12-22T14:16:43Z + quality + PATO:0045013 + + normal curvature + + + + + + + + + + + + + + + + + + + + + A life span which is relatively normal or average. + Luke Slater + 2017-12-22T14:16:43Z + quality + PATO:0045026 + normal life span + + + + + + + + + + + + + + + + + + + + + A size quality which is relatively normal or average + Luke Slater + 2017-12-22T14:16:43Z + quality + PATO:0045050 + + normal size + + + + + + + + + A cell morphology that inheres in neurons which have a small round soma, a large number of short, smooth, or slightly beaded primary dendrites that give rise to only a few secondary branches, and a branched axon that establishes a dense axonal mesh with thin shafts. + http://orcid.org/0000-0001-7258-9596 + ilxtr:NeurogliaformPhenotype + quality + PATO:0070001 + neurogliaform morphology + + + + + A cell morphology that inheres in neurons which have a small round soma, a large number of short, smooth, or slightly beaded primary dendrites that give rise to only a few secondary branches, and a branched axon that establishes a dense axonal mesh with thin shafts. + PMID:17122314 + + + + + + + + + A cell morphology that inheres in multipolar neurons with densely branched terminal axonal arborizations that form basket-like structures surrounding and synapsing to the somas of target cells. + http://orcid.org/0000-0001-7258-9596 + ILX:0101123 + ilxtr:BasketPhenotype + nifext:3 + quality + PATO:0070002 + basket cell morphology + + + + + A cell morphology that inheres in multipolar neurons with densely branched terminal axonal arborizations that form basket-like structures surrounding and synapsing to the somas of target cells. + WikipediaVersioned:Basket_cell&oldid=951703880 + doi:10.1016/b978-0-12-369497-3.10004-4 + + + + + + + + + A basket cell morphology that inheres in neurons with axonal arbors composed of frequent, short, curvy axonal branches that tend to be near their somata and within the same layer. + http://orcid.org/0000-0001-7258-9596 + ilxtr:SmallBasketPhenotype + quality + PATO:0070003 + small basket cell morphology + + + + + A basket cell morphology that inheres in neurons with axonal arbors composed of frequent, short, curvy axonal branches that tend to be near their somata and within the same layer. + PMID:11884355 + + + + + + + + + A basket cell morphology that inheres in neurons that are large, and typically ascend to give rise to many long horizontally and vertically projecting axon collaterals that traverse neighboring columns and can extend through all cortical layers. + http://orcid.org/0000-0001-7258-9596 + ilxtr:LargeBasketPhenotype + quality + PATO:0070004 + large basket cell morphology + + + + + A basket cell morphology that inheres in neurons that are large, and typically ascend to give rise to many long horizontally and vertically projecting axon collaterals that traverse neighboring columns and can extend through all cortical layers. + PMID:11884355 + + + + + + + + + A basket cell morphology that inheres in neurons which have simpler dendritic arbors (compared to small or large basket cell morphology), and an axonal plexus of intermediate density, composed of a few long, smooth axonal branches. + http://orcid.org/0000-0001-7258-9596 + ilxtr:NestBasketPhenotype + quality + PATO:0070005 + nest basket cell morphology + + + + + A basket cell morphology that inheres in neurons which have simpler dendritic arbors (compared to small or large basket cell morphology), and an axonal plexus of intermediate density, composed of a few long, smooth axonal branches. + PMID:11884355 + + + + + + + + + A cell morphology that inheres in neurons which have two principal fibres (dendrites or axon) that emerge from the soma and begin to branch some distance from it, have few spines, and branch in narrow fields. This is in contrast to bitufted morphology where branching occurs close to the soma. + http://orcid.org/0000-0001-7258-9596 + ILX:0101312 + ilxtr:BipolarPhenotype + nifext:2 + quality + PATO:0070006 + bipolar morphology + + + + + A cell morphology that inheres in neurons which have two principal fibres (dendrites or axon) that emerge from the soma and begin to branch some distance from it, have few spines, and branch in narrow fields. This is in contrast to bitufted morphology where branching occurs close to the soma. + PMID:18568015 + doi:10.1016/b978-0-12-369497-3.10004-4 + + + + + + + + + A cell morphology that inheres in neurons which are large and non-spiny, with dendrites radiating in a multipolar or bitufted pattern, often favouring the descending side, and axons that ascend directly from the superficial side of the soma, and travel upward without branching. + http://orcid.org/0000-0001-7258-9596 + ilxtr:MartinottiPhenotype + quality + PATO:0070007 + martinotti morphology + + + + + A cell morphology that inheres in neurons which are large and non-spiny, with dendrites radiating in a multipolar or bitufted pattern, often favouring the descending side, and axons that ascend directly from the superficial side of the soma, and travel upward without branching. + doi:10.1016/b978-0-12-369497-3.10004-4 + + + + + + + + + A martinotti cell morphology that inheres in neurons which have axons that form a horizontal ramification, making it T-shaped. + http://orcid.org/0000-0001-7258-9596 + quality + PATO:0070008 + 'T-shaped' martinotti morphology + + + + + A martinotti cell morphology that inheres in neurons which have axons that form a horizontal ramification, making it T-shaped. + doi:10.1016/b978-0-12-369497-3.10004-4 + + + + + + + + + A martinotti cell morphology that inheres in neurons which have axons that form a fan-like plexus. + http://orcid.org/0000-0001-7258-9596 + quality + PATO:0070009 + 'fanning-out' martinotti morphology + + + + + A martinotti cell morphology that inheres in neurons which have axons that form a fan-like plexus. + doi:10.1016/b978-0-12-369497-3.10004-4 + + + + + + + + + A cell morphology that inheres in neurons that have dendritic processes radiating from the cell body forming a star-like shape. + http://orcid.org/0000-0001-7258-9596 + ILX:0111036 + SAO:9271919883 + quality + PATO:0070010 + stellate morphology + + + + + A cell morphology that inheres in neurons that have dendritic processes radiating from the cell body forming a star-like shape. + ISBN:9780123973481 + + + + + + + + + A cell morphology that inheres in neurons which are small and round, and make highly specialized synapses with the axon initial segments of pyramidal neurons, wrapping them with candle-shaped synaptic “cartridges”. + http://orcid.org/0000-0001-7258-9596 + ILX:0102028 + ilxtr:ChandelierPhenotype + nifext:4 + quality + PATO:0070011 + Chandelier cells can be bitufted or multipolar. + chandelier cell morphology + + + + + A cell morphology that inheres in neurons which are small and round, and make highly specialized synapses with the axon initial segments of pyramidal neurons, wrapping them with candle-shaped synaptic “cartridges”. + doi:10.1016/b978-0-12-369497-3.10004-4 + + + + + Chandelier cells can be bitufted or multipolar. + DOI:10.1016/B978-0-12-369497-3.10004-4 + + + + + + + + + A cell morphology that inheres in neurons which have two clusters of primary dendrites that originate directly and extend from opposite ends of the soma, and axons that form a plexus which spreads widely. Compared to the narrow vertical axonal projection of bipolar morphology, and the 'horse-tail' axonal cluster of double boquet cells, bitufted morphology has wide horizontal axonal spans, and branching that occur close to the soma. Their vertical projection is also less extensive and crosses mostly to neighboring layers. + http://orcid.org/0000-0001-7258-9596 + ilxtr:BituftedPhenotype + quality + PATO:0070012 + bitufted cell morphology + + + + + A cell morphology that inheres in neurons which have two clusters of primary dendrites that originate directly and extend from opposite ends of the soma, and axons that form a plexus which spreads widely. Compared to the narrow vertical axonal projection of bipolar morphology, and the 'horse-tail' axonal cluster of double boquet cells, bitufted morphology has wide horizontal axonal spans, and branching that occur close to the soma. Their vertical projection is also less extensive and crosses mostly to neighboring layers. + PMID:15378039 + PMID:18568015 + doi:10.1016/b978-0-12-369497-3.10004-4 + + + + + + + + + A cell morphology that inheres in neurons which have spiny basal dendrites and resemble pyramidal cells but lose their apical dendrites as they mature. Their axons nearly always emerge from the descending side of the soma, but often recurve and ascend with arc-like collaterals. + http://orcid.org/0000-0001-7258-9596 + ilxtr:SpinyStellatePhenotype + quality + PATO:0070013 + spiny stellate cell morphology + + + + + A cell morphology that inheres in neurons which have spiny basal dendrites and resemble pyramidal cells but lose their apical dendrites as they mature. Their axons nearly always emerge from the descending side of the soma, but often recurve and ascend with arc-like collaterals. + doi:10.1016/b978-0-12-369497-3.10004-4 + + + + + + + + + A cell morphology that inheres in neurons which have a pyramidal shaped soma, a single axon, a large apical dendrite and multiple basal dendrites. + http://orcid.org/0000-0001-7258-9596 + ILX:0109553 + SAO:1465673360 + quality + PATO:0070015 + pyramidal family morphology + + + + + A cell morphology that inheres in neurons which have a pyramidal shaped soma, a single axon, a large apical dendrite and multiple basal dendrites. + doi:10.1016/b978-0-12-369497-3.10004-4 + + + + + + + + + + A pyramidal family morphology that inheres in neurons which have an apical tree which is oriented parallel to the pia. + http://orcid.org/0000-0001-7258-9596 + ilxtr:HorizontalPyramidalPhenotype + quality + PATO:0070016 + horizontal pyramidal morphology + + + + + A pyramidal family morphology that inheres in neurons which have an apical tree which is oriented parallel to the pia. + PMID:30715238 + + + + + + + + + A pyramidal family morphology that inheres in neurons which have a standard pyramidal shape with its apical dendrite aligned vertically. + http://orcid.org/0000-0001-7258-9596 + ilxtr:PyramidalPhenotype + pyramidal cell morphology + vertical pyramidal morphology + quality + PATO:0070017 + standard pyramidal morphology + + + + + A pyramidal family morphology that inheres in neurons which have a standard pyramidal shape with its apical dendrite aligned vertically. + doi:10.1016/b978-0-12-369497-3.10004-4 + + + + + + + + + A pyramidal cell morphology that inheres in neurons which have a distinct tuft formation, distal from the soma. + http://orcid.org/0000-0001-7258-9596 + ilxtr:TuftedPyramidalPhenotype + quality + PATO:0070018 + tufted pyramidal morphology + + + + + A pyramidal cell morphology that inheres in neurons which have a distinct tuft formation, distal from the soma. + PMID:30715238 + + + + + + + + + A pyramidal cell morphology that inheres in neurons which lack a clear tuft formation but extend to large radial distances. + http://orcid.org/0000-0001-7258-9596 + ilxtr:UntuftedPyramidalPhenotype + quality + PATO:0070019 + untufted pyramidal morphology + + + + + A pyramidal cell morphology that inheres in neurons which lack a clear tuft formation but extend to large radial distances. + PMID:30715238 + + + + + + + + + A pyramidal cell morphology that inheres in neurons which lack a tuft formation but extend to small radial distances forming a star-like shape. + http://orcid.org/0000-0001-7258-9596 + ilxtr:StarPyramidalPhenotype + quality + PATO:0070020 + stellate pyramidal morphology + + + + + A pyramidal cell morphology that inheres in neurons which lack a tuft formation but extend to small radial distances forming a star-like shape. + PMID:30715238 + + + + + + + + + A pyramidal cell morphology that inheres in neurons which have an apical tree which is oriented towards the white matter. + http://orcid.org/0000-0001-7258-9596 + ilxtr:InvertedPyramidalPhenotype + quality + PATO:0070021 + inverted pyramidal morphology + + + + + A pyramidal cell morphology that inheres in neurons which have an apical tree which is oriented towards the white matter. + PMID:30715238 + + + + + + + + + A cell morphology that inheres in neurons which possess a single axon and many dendrites and dendritic branches. + http://orcid.org/0000-0001-7258-9596 + ILX:0107196 + NLX:378 + quality + PATO:0070026 + multipolar neuron morphology + + + + + A cell morphology that inheres in neurons which possess a single axon and many dendrites and dendritic branches. + WikipediaVersioned:Multipolar_neuron&oldid=1022942606 + + + + + + + + + A neuron projection quality that is a characteristic of neurons whose soma is located in the telencephalon and that project to structures outside the telencephalon + http://orcid.org/0000-0001-7258-9596 + ILX:0770101 + ET projecting + quality + PATO:0070028 + extratelencephalic projecting + + + + + A neuron projection quality that is a characteristic of neurons whose soma is located in the telencephalon and that project to structures outside the telencephalon + DOI:10.1101/2020.10.19.343129 + + + + + + + + + A neuron projection quality that is a characteristic of neurons with soma in the cerebral cortex and projections to the thalamus. + http://orcid.org/0000-0001-7258-9596 + ILX:0770102 + CT projecting + quality + PATO:0070029 + corticothalamic projecting + + + + + A neuron projection quality that is a characteristic of neurons with soma in the cerebral cortex and projections to the thalamus. + DOI:10.1101/2020.10.19.343129 + + + + + + + + + A neuron projection quality that is a characteristic of neurons with projections that terminate locally rather than distantly. + http://orcid.org/0000-0001-7258-9596 + ILX:0770103 + NP + quality + PATO:0070030 + near projecting + + + + + A neuron projection quality that is a characteristic of neurons with projections that terminate locally rather than distantly. + DOI:10.1101/2020.10.19.343129 + + + + + + + + + A neuron projection quality that is a characteristic of neurons that project to the medulla oblongata from other brain regions. + http://orcid.org/0000-0001-7258-9596 + MY projecting + quality + PATO:0070031 + corticomedulla projecting + + + + + A neuron projection quality that is a characteristic of neurons that project to the medulla oblongata from other brain regions. + DOI:10.1101/2020.10.19.343129 + + + + + + + + + A physical quality inhering in a neuron by virtue of the relative location of its soma and the regions to which it projects and makes synaptic contacts in. + http://orcid.org/0000-0001-7258-9596 + quality + PATO:0070033 + neuron projection quality + + + + + A physical quality inhering in a neuron by virtue of the relative location of its soma and the regions to which it projects and makes synaptic contacts in. + DOI:10.1101/2020.10.19.343129 + + + + + + + + + A neuron projection quality that is a characteristic of neurons with both soma and projections entirely within the telencephalon. + http://orcid.org/0000-0001-7258-9596 + ILX:0770100 + IT projecting + quality + PATO:0070034 + intratelencephalic projecting + + + + + A neuron projection quality that is a characteristic of neurons with both soma and projections entirely within the telencephalon. + DOI:10.1101/2020.10.19.343129 + + + + + + + + + An occurrent [span:Occurrent] that exists in time by occurring or happening, has temporal parts and always involves and depends on some entity. + uberon + UBERON:0000000 + + processual entity + + + + + An occurrent [span:Occurrent] that exists in time by occurring or happening, has temporal parts and always involves and depends on some entity. + span:ProcessualEntity + + + + + + + + + + + + + + + + + + + + + A layer of dense irregular connective tissue that lines organs and supports the mucosa, as well as joins the mucosa to the bulk of underlying smooth muscle. [WP,unvetted]. + submucosal + + + + BTO:0002107 + FMA:85391 + FMA:85392 + NCIT:C13167 + UMLS:C0225344 + organ submucosa + region of submucosa + submucosa of organ + submucosa of region of organ + uberon + submucous layer + tela submucosa + tunica submucosa + UBERON:0000009 + + + submucosa + http://upload.wikimedia.org/wikipedia/commons/4/4e/Ens.png + http://upload.wikimedia.org/wikipedia/en/thumb/4/4e/Ens.png/200px-Ens.png + + + + + A layer of dense irregular connective tissue that lines organs and supports the mucosa, as well as joins the mucosa to the bulk of underlying smooth muscle. [WP,unvetted]. + + + + + + UMLS:C0225344 + ncithesaurus:Submucosa + + + + + organ submucosa + FMA:85391 + + + + + region of submucosa + FMA:85392 + + + + + submucosa of organ + FMA:85391 + + + + + submucosa of region of organ + FMA:85392 + + + + + submucous layer + BTO:0002107 + + + + + tela submucosa + BTO:0002107 + + + + + + + + + + + + + + + + A major division of the nervous system that contains nerves which connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands. + Nervous structures including ganglia outside of the central nervous system. Kimmel et al, 1995.[TAO] + Part of nervous system in which nerves extend throughout the body outside of the brain and spinal cord.[AAO] + The peripheral nervous system (PNS) is the part of the nervous system connected to the CNS which contains cranial nerves III - XII, spinal, peripheral and autonomic nerves. (CUMBO) + (...) specific vertebrate traits within the chordate phylum such as skeletal tissues, PNS, and spectacular head and brain development, are linked to the NC (neural crest) and its derivatives.[well established][VHOG] + PNS + + + + + + AAO:0000429 + BAMS:PNS + BILA:0000081 + BIRNLEX:1111 + BTO:0001028 + CALOHA:TS-0808 + EFO:0000891 + EHDAA2:0001445 + EHDAA:2893 + EMAPA:16665 + EV:0100335 + FBbt:00005098 + FMA:9903 + GAID:715 + MA:0000218 + MAT:0000338 + MESH:D017933 + MIAA:0000338 + NCIT:C12465 + TAO:0000142 + UMLS:C0206417 + UMLS:C1305921 + VHOG:0000399 + XAO:0000178 + ZFA:0000142 + pars peripherica + systema nervosum periphericum + uberon + UBERON:0000010 + + + + + + peripheral nervous system + http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png + + + + + + cjm + + + + + A major division of the nervous system that contains nerves which connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands. + GO:0007422 + + + + + Nervous structures including ganglia outside of the central nervous system. Kimmel et al, 1995.[TAO] + 2012-08-14 + TAO:0000142 + TAO + ZFIN:curator + + + + + Part of nervous system in which nerves extend throughout the body outside of the brain and spinal cord.[AAO] + 2012-06-20 + AAO:0000429 + AAO + AAO:BJB + + + + + The peripheral nervous system (PNS) is the part of the nervous system connected to the CNS which contains cranial nerves III - XII, spinal, peripheral and autonomic nerves. (CUMBO) + + + + + + (...) specific vertebrate traits within the chordate phylum such as skeletal tissues, PNS, and spectacular head and brain development, are linked to the NC (neural crest) and its derivatives.[well established][VHOG] + 2012-09-17 + VHOG:0000399 + VHOG + + DOI:10.1007/978-0-387-46954-6_6 Dupin E, Creuzet S, Le Douarin NM, The contribution of the neural crest to the vertebrate body. Advances in experimental medicine and biology (2006) + + + + + PNS + + + + + + UMLS:C0206417 + BIRNLEX:1111 + + + + + UMLS:C0206417 + ncithesaurus:Peripheral_Nervous_System + + + + + UMLS:C1305921 + BIRNLEX:1111 + + + + + pars peripherica + + FMA:9903 + FMA:TA + + + + + + systema nervosum periphericum + + FMA:9903 + FMA:TA + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any portion of the organ that covers that body and consists of a layer of epidermis and a layer of dermis. + Note the distinction between the entire skin of the body, of which there is only 1 in an organism, and zones of skin, of which there can be many. Examples: skin of knee + (...) it is well-established that neural crest cells contribute to both the dermal skeleton (craniofacial bone, teeth, and the caudal fin rays of teleosts) and the integument, including craniofacial dermis and all pigment cells outside the retina (...).[well established][VHOG] + we assume that mouse, HOG and GAID all mean zone of skin when they say skin. We also choose skin as an exact synonym, as it is more intuitive + + + EHDAA2:0001844 + EHDAA:6530 + EMAPA:17525 + EV:0100152 + FMA:86166 + GAID:933 + MA:0000151 + MAT:0000284 + MESH:D012867 + MIAA:0000284 + OpenCyc:Mx4rvVjX3ZwpEbGdrcN5Y29ycA + VHOG:0000860 + portion of skin + region of skin + skin + skin region + skin zone + uberon + UBERON:0000014 + + zone of skin + http://upload.wikimedia.org/wikipedia/commons/6/6d/Skin.svg + http://upload.wikimedia.org/wikipedia/commons/e/e8/HumanSkinDiagram.jpg + + + + + + FMA + + + + + Any portion of the organ that covers that body and consists of a layer of epidermis and a layer of dermis. + + + + + + + (...) it is well-established that neural crest cells contribute to both the dermal skeleton (craniofacial bone, teeth, and the caudal fin rays of teleosts) and the integument, including craniofacial dermis and all pigment cells outside the retina (...).[well established][VHOG] + 2012-09-17 + VHOG:0000860 + VHOG + + DOI:10.1111/j.1469-7580.2008.01043.x Vickaryous MK, Sire JY, The integumentary skeleton of tetrapods: origin, evolution, and development. J Anat (2009) + + + + + skin + MA:0000151 + + + + + + + + + A non-material anatomical entity of two dimensions. Anatomical boundaries are contiguous structures. + AEO:0000192 + CARO:0000010 + FMA:50705 + anatomical boundary + uberon + UBERON:0000015 + + Except in the case of abstracted fiat boundaries such as the midline plane of an organism, all 2D anatomical entities have a 3 dimensional projection. For example, the surface of the shell of a muscle has a distinct shape that projects into the third dimension. Note that boundaries are 2D structures. They have no thickness - and so can not be sites of gene expression or gene product localisation. For this, use boundary region terms. + non-material anatomical boundary + + + + + + CARO + + + + + A non-material anatomical entity of two dimensions. Anatomical boundaries are contiguous structures. + CARO:0000010 + + + + + anatomical boundary + CARO:0000010 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An organ of sight that includes the camera-type eyeball and supporting structures such as the lacrimal apparatus, the conjunctiva, the eyelid. + A cavitated compound organ that transduces light waves into neural signals.[TAO] + The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG] + FMA distinguishes Eye (subdivision of face) which has its parts an Eyeball (organ), as well as other structures, and the orbit of skull. MA includes eyelid, conjunctiva and lacrimal apparatus as part of MA:eye - consistent with FMA - so we can infer that MA:eye is more like FMA:eye than FMA:eyeball. For other AOs this distinction is less meaningful - e.g. ZFA has no eyelid; XAO has no eyelid, but it has conjuctiva, which is considered part of the xao:eye. GO considers eyelid development part of eye development. See also notes on optic nerve - XAO, AAO and BTO consider this part of the eye. MA considers the eye muscles part of the eye, whereas FMA has a class 'orbital content' for this + eye + + + + AAO:0010340 + BIRNLEX:1169 + BTO:0004688 + EHDAA2:0000484 + EHDAA:936 + EMAPA:16198 + FMA:54448 + MA:0000261 + NCIT:C12401 + OpenCyc:Mx8Ngx4rwKSh9pwpEbGdrcN5Y29ycB4rvVil5pwpEbGdrcN5Y29ycB4rvViTvpwpEbGdrcN5Y29ycA + TAO:0000107 + UMLS:C0015392 + UMLS:C1280202 + VHOG:0000275 + XAO:0000179 + ZFA:0000107 + regio orbitalis + vertebrate eye + uberon + camera-type eye plus associated structures + eyes + orbital part of face + orbital region + UBERON:0000019 + + + + camera-type eye + + + + + + + + + + + definitional + + + + + An organ of sight that includes the camera-type eyeball and supporting structures such as the lacrimal apparatus, the conjunctiva, the eyelid. + + GO:0043010 + + + + + A cavitated compound organ that transduces light waves into neural signals.[TAO] + 2012-08-14 + TAO:0000107 + TAO + TAO:wd + + + + + The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG] + 2012-09-17 + VHOG:0000275 + VHOG + + DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007) + + + + + FMA distinguishes Eye (subdivision of face) which has its parts an Eyeball (organ), as well as other structures, and the orbit of skull. MA includes eyelid, conjunctiva and lacrimal apparatus as part of MA:eye - consistent with FMA - so we can infer that MA:eye is more like FMA:eye than FMA:eyeball. For other AOs this distinction is less meaningful - e.g. ZFA has no eyelid; XAO has no eyelid, but it has conjuctiva, which is considered part of the xao:eye. GO considers eyelid development part of eye development. See also notes on optic nerve - XAO, AAO and BTO consider this part of the eye. MA considers the eye muscles part of the eye, whereas FMA has a class 'orbital content' for this + FMA + + + + + eye + FMA:54448 + + + + + UMLS:C0015392 + BIRNLEX:1169 + + + + + UMLS:C0015392 + ncithesaurus:Eye + + + + + UMLS:C1280202 + BIRNLEX:1169 + + + + + regio orbitalis + FMA:54448 + FMA:TA + + + + + + eyes + TAO:0000107 + + + + + + orbital part of face + FMA:54448 + + + + + orbital region + FMA:54448 + + + + + + + + + + + + + + + An organ that is capable of transducing sensory stimulus to the nervous system. + + + + AEO:0000094 + BSA:0000121 + BTO:0000202 + CALOHA:TS-2043 + EHDAA2:0001824 + EHDAA:500 + EMAPA:35955 + FBbt:00005155 + GAID:63 + HAO:0000930 + MA:0000017 + MESH:D012679 + NCIT:C33224 + UMLS:C0935626 + VHOG:0001407 + WBbt:0006929 + organ of sense organ system + organ of sensory organ system + organ of sensory system + sense organ system organ + sensory organ + sensory organ system organ + sensory system organ + sensillum + uberon + Sinnesorgan + sensor + UBERON:0000020 + + sense organ + http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray722.png + + + + + An organ that is capable of transducing sensory stimulus to the nervous system. + + + + + + + UMLS:C0935626 + ncithesaurus:Organ_of_the_Special_Sense + + + + + organ of sense organ system + OBOL:accepted + + + + + organ of sensory organ system + OBOL:accepted + + + + + organ of sensory system + OBOL:accepted + + + + + sense organ system organ + OBOL:automatic + + + + + sensory organ system organ + OBOL:automatic + + + + + sensory system organ + OBOL:accepted + + + + + sensillum + WBbt:0006929 + + + + + Sinnesorgan + BTO:0000202 + + + + + + + + + + + + + + + Any hollow cylindrical anatomical structure containing a lumen through which substances are transported. + not every anatomical conduit is a tube - for example, a bone foramen is an opening in the bone, and there is no distinct separate tube structure. Tubes may transport large mixed objects (for example, a bolus of food in the digestive tube) or they may transport the secretions of a single gland (for example, gland ducts) + tubular + galen:Tube + anatomical tube + duct + uberon + UBERON:0000025 + tube + + + + + Any hollow cylindrical anatomical structure containing a lumen through which substances are transported. + + + + + + + + + + + + + + + + + + + + + + + + + + + + A thin layer of loose connective tissue which lies beneath the epithelium and together with the epithelium constitutes the mucosa[WP]. The lamina propria contains capillaries and a central lacteal (lymph vessel) in the small intestine, as well as lymphoid tissue. Lamina propria also contains glands with the ducts opening on to the mucosal epithelium, that secrete mucus and serous secretions. + + + + BTO:0002330 + FMA:62517 + NCIT:C32918 + UMLS:C1179187 + lamina propria mucosa + lamina propria mucosae + uberon + tunica propria + UBERON:0000030 + + lamina propria + GI:Organization.svg + + + + + A thin layer of loose connective tissue which lies beneath the epithelium and together with the epithelium constitutes the mucosa[WP]. The lamina propria contains capillaries and a central lacteal (lymph vessel) in the small intestine, as well as lymphoid tissue. Lamina propria also contains glands with the ducts opening on to the mucosal epithelium, that secrete mucus and serous secretions. + + + + + + UMLS:C1179187 + ncithesaurus:Lamina_Propria + + + + + tunica propria + BTO:0002330 + + + + + + + + + + + + + + + The head is the anterior-most division of the body [GO]. + Organism subdivision that is the part of the body consisting of the cranial and pharyngeal regions.[AAO] + Organism subdivision which is the part of the body which consists of the cranial and pharygeal regions.[TAO] + Vertebrate evolution has been characterized by a fresh and vast array of cranial structures that collectively form the head.[well established][VHOG] + + + + AAO:0010335 + AEO:0000106 + BILA:0000115 + BIRNLEX:1230 + BTO:0000282 + CALOHA:TS-0436 + EFO:0000964 + EHDAA2:0003106 + EMAPA:31858 + FBbt:00000004 + FMA:7154 + GAID:61 + HAO:0000397 + MA:0000023 + MAT:0000294 + MESH:D006257 + MIAA:0000294 + NCIT:C12419 + OpenCyc:Mx4rEOLm4rgPEdmAAAACs6hRjg + OpenCyc:Mx4rvVi6YJwpEbGdrcN5Y29ycA + SPD:0000016 + TAO:0001114 + TGMA:0000002 + UMLS:C0018670 + VHOG:0001644 + WBbt:0005739 + XAO:0003024 + ZFA:0001114 + galen:Head + head (volume) + adult head + uberon + cephalic area + UBERON:0000033 + + + + + head + + + + + The head is the anterior-most division of the body [GO]. + + GO:0060322 + + + + + Organism subdivision that is the part of the body consisting of the cranial and pharyngeal regions.[AAO] + 2012-06-20 + AAO:0010335 + AAO + AAO:BJB + + + + + Organism subdivision which is the part of the body which consists of the cranial and pharygeal regions.[TAO] + 2012-08-14 + TAO:0001114 + TAO + ZFIN:curator + + + + + Vertebrate evolution has been characterized by a fresh and vast array of cranial structures that collectively form the head.[well established][VHOG] + 2012-09-17 + VHOG:0001644 + VHOG + + ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.82 + + + + + UMLS:C0018670 + BIRNLEX:1230 + + + + + UMLS:C0018670 + ncithesaurus:Head + + + + + head (volume) + FMA:7154 + + + + + cephalic area + SPD:0000016 + + + + + + + + + + + + + + + + + + + + + + + + + + + + multi-tissue structure that is comprised of a secretory epithelial layer (mesothelium) and a connective tissue layer. + A multi-tissue structure that is comprised of a secretory epithelial layer and a connective tissue layer.[TAO] + a smooth membrane consisting of a thin layer of cells which excrete serous fluid. Serous membranes line and enclose several body cavities, known as serous cavities, where they secrete a lubricating fluid which reduces friction from muscle movement. Serosa is not to be confused with adventitia, a connective tissue layer which binds together structures rather than reducing friction between them. Each serous membrane is composed of a secretory epithelial layer and a connective tissue layer underneath. The epithelial layer, known as mesothelium, consists of a single layer of avascular flat nucleated cells (cuboidal epithelium) which produce the lubricating serous fluid. This fluid has a consistency similar to thin mucus. These cells are bound tightly to the underlying connective tissue. The connective tissue layer provides the blood vessels and nerves for the overlying secretory cells, and also serves as the binding layer which allows the whole serous membrane to adhere to organs and other structures.[WP] + in FMA, SM = mesothelium + connective tissue. It excludes the cavity. Serous sac = SM + cavity. Note that the SM is a subtype of wall in FMA. + + + + + FMA:9581 + GAID:19 + MESH:D012704 + NCIT:C13169 + TAO:0005425 + UMLS:C0036760 + ZFA:0005425 + tunica serosa + wall of serous sac + uberon + serosa + UBERON:0000042 + + + serous membrane + http://upload.wikimedia.org/wikipedia/commons/4/4e/Ens.png + http://upload.wikimedia.org/wikipedia/en/thumb/4/4e/Ens.png/200px-Ens.png + + + + + multi-tissue structure that is comprised of a secretory epithelial layer (mesothelium) and a connective tissue layer. + + + + + + + A multi-tissue structure that is comprised of a secretory epithelial layer and a connective tissue layer.[TAO] + 2012-08-14 + TAO:0005425 + TAO + + + + + + a smooth membrane consisting of a thin layer of cells which excrete serous fluid. Serous membranes line and enclose several body cavities, known as serous cavities, where they secrete a lubricating fluid which reduces friction from muscle movement. Serosa is not to be confused with adventitia, a connective tissue layer which binds together structures rather than reducing friction between them. Each serous membrane is composed of a secretory epithelial layer and a connective tissue layer underneath. The epithelial layer, known as mesothelium, consists of a single layer of avascular flat nucleated cells (cuboidal epithelium) which produce the lubricating serous fluid. This fluid has a consistency similar to thin mucus. These cells are bound tightly to the underlying connective tissue. The connective tissue layer provides the blood vessels and nerves for the overlying secretory cells, and also serves as the binding layer which allows the whole serous membrane to adhere to organs and other structures.[WP] + + + + + + in FMA, SM = mesothelium + connective tissue. It excludes the cavity. Serous sac = SM + cavity. Note that the SM is a subtype of wall in FMA. + FMA + + + + + UMLS:C0036760 + ncithesaurus:Serosa + + + + + tunica serosa + FMA:9581 + + + + + + wall of serous sac + FMA:9581 + + + + + serosa + + + + + + + + + + An eye with one concave chamber. Note that 'simple' does not imply a reduced level of complexity or acuity. + + TGMA:0000729 + uberon + UBERON:0000047 + + + simple eye + + + + + An eye with one concave chamber. Note that 'simple' does not imply a reduced level of complexity or acuity. + + + + + + + + + + + + + + + + A tubular structure that contains, conveys body fluid, such as blood or lymph. + uberon + UBERON:0000055 + + + vessel + + + + + A tubular structure that contains, conveys body fluid, such as blood or lymph. + + + + + + + + + + + + + + + + + + + + + + A tubular structure that transports secreted or excreted substances. + A tube shaped portion of tissue lined with epithelial cells that collects secretions and routes them to their destination[ZFA:0005171]. + Most ducts, but not all, are exocrine gland ducts. Some ontologies classify structures such as the oviduct here. + + + + AAO:0011123 + FBbt:00100314 + FMA:30320 + NCIT:C12948 + TAO:0005171 + UMLS:C0687028 + XAO:0004000 + ZFA:0005171 + galen:Duct + anatomical duct + exocrine duct + exocrine gland duct + uberon + ducts + UBERON:0000058 + + duct + + + + + A tubular structure that transports secreted or excreted substances. + + + + + + + A tube shaped portion of tissue lined with epithelial cells that collects secretions and routes them to their destination[ZFA:0005171]. + ZFA:0005171 + + + + + UMLS:C0687028 + ncithesaurus:Duct + + + + + ducts + XAO:0004000 + + + + + + + + + + + + + + + + + + + + + + Organ component adjacent to an organ cavity and which consists of a maximal aggregate of organ component layers. + in FMA, serosa is a wall + UBERON:0009915 + wall + EMAPA:25036 + FMA:82482 + galen:Wall + wall of organ + uberon + organ wall + UBERON:0000060 + + anatomical wall + + + + + Organ component adjacent to an organ cavity and which consists of a maximal aggregate of organ component layers. + FMA:82482 + + + + + in FMA, serosa is a wall + FMA + + + + + wall of organ + FMA:82482 + + + + + organ wall + FMA:82482 + + + + + + + + + + + + + + + + + + + + + Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome. + + + AAO:0010825 + AEO:0000003 + BILA:0000003 + CARO:0000003 + EHDAA2:0003003 + EMAPA:0 + FBbt:00007001 + FMA:305751 + FMA:67135 + GAID:781 + HAO:0000003 + MA:0003000 + MESH:D000825 + TAO:0000037 + TGMA:0001823 + VHOG:0001759 + XAO:0003000 + ZFA:0000037 + biological structure + connected biological structure + uberon + UBERON:0000061 + + anatomical structure + + + + + Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome. + CARO:0000003 + + + + + connected biological structure + CARO:0000003 + + + + + + + + + + + + + + + + + + + + + + + + + + + + Anatomical structure that performs a specific function or group of functions [WP]. + Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. + CARO v1 does not include a generic 'organ' class, only simple and compound organ. CARO v2 may include organ, see https://github.com/obophenotype/caro/issues/4 + + + + BIRNLEX:4 + CARO:0020004 + EFO:0000634 + EMAPA:35949 + ENVO:01000162 + FMA:67498 + MA:0003001 + NCIT:C13018 + OpenCyc:Mx4rv5XMb5wpEbGdrcN5Y29ycA + OpenCyc:Mx4rwP3iWpwpEbGdrcN5Y29ycA + UMLS:C0178784 + WBbt:0003760 + uberon + anatomical unit + body organ + element + UBERON:0000062 + + organ + + + + + Anatomical structure that performs a specific function or group of functions [WP]. + + + + + + Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. + GO:0048513 + + + + + UMLS:C0178784 + ncithesaurus:Organ + + + + + element + + + + + + + + + + A part of an organ that constitutes a distinct modular sub-unit. In some cases, the organ may also contain other sub-units of identical or similar types, in other cases this may be a distinct entity. + FMA distinguishes segment from zone by whether the fiat boundaries are fixed/anchored (segments) or floating (zone). It's not completely clear how to apply this distinction + Organ region with one or more anchored fiat boundaries. Examples: artery, trunk of nerve, cervical part of esophagus, pelvic part of vagina, horn of thyroid cartilage, anterior segment of eyeball. + Organ region with one or more fixed or anchored fiat boundaries. Examples: artery, trunk of nerve, cervical part of esophagus, pelvic part of vagina, horn of thyroid cartilage, anterior segment of eyebal. + FMA:86140 + uberon + organ region with fixed fiat boundary + organ segment + segment of organ + UBERON:0000063 + + organ subunit + + + + + A part of an organ that constitutes a distinct modular sub-unit. In some cases, the organ may also contain other sub-units of identical or similar types, in other cases this may be a distinct entity. + + + + + + Organ region with one or more anchored fiat boundaries. Examples: artery, trunk of nerve, cervical part of esophagus, pelvic part of vagina, horn of thyroid cartilage, anterior segment of eyeball. + FMA:86140 + 3 + + + + + Organ region with one or more fixed or anchored fiat boundaries. Examples: artery, trunk of nerve, cervical part of esophagus, pelvic part of vagina, horn of thyroid cartilage, anterior segment of eyebal. + FMA:86140 + 1 + + + + + organ region with fixed fiat boundary + FMA:86140 + + + + + organ segment + FMA:86140 + + + + + segment of organ + FMA:86140 + + + + + + + + + + + + + + + A multicellular structure that is a part of an organ. + currently defined in a very broad sense, may be replaced by more specific classes in the future + + + AAO:0011124 + BIRNLEX:16 + EFO:0000635 + FMA:82472 + cardinal organ part + uberon + regional part of organ + UBERON:0000064 + + + + organ part + + + + + A multicellular structure that is a part of an organ. + + + + + + cardinal organ part + FMA:82472 + + + + + regional part of organ + BIRNLEX:16 + + + + + + + + + + + + + + + + + + + + + + + + + + + + The stage of development at which the animal is fully formed, including immaturity and maturity. Includes both sexually immature stage, and adult stage. + adult stage + BTO:0001043 + BilaDO:0000004 + EFO:0001272 + FBdv:00005369 + WBls:0000041 + XtroDO:0000084 + fully formed animal stage + juvenile-adult stage + uberon + UBERON:0000066 + + fully formed stage + https://github.com/obophenotype/uberon/issues/566 + + + + + The stage of development at which the animal is fully formed, including immaturity and maturity. Includes both sexually immature stage, and adult stage. + + + + + + + + + + + + + + + + + + + + + + + + A life cycle stage that starts with fertilization and ends with the fully formed embryo. + + BilaDO:0000002 + EV:0300001 + FBdv:00005289 + FMA:72652 + HsapDv:0000002 + MmusDv:0000002 + OGES:000000 + OGES:000022 + WBls:0000003 + WBls:0000092 + WBls:0000102 + XAO:1000012 + embryonic stage + uberon + embryogenesis + UBERON:0000068 + embryo stage + + + + + A life cycle stage that starts with fertilization and ends with the fully formed embryo. + + + + + + + + + + + + + + + + End of the life of an organism. + ncit:Death is an outcome + XAO:0000437 + XtroDO:0000085 + uberon + death + UBERON:0000071 + death stage + + + + + End of the life of an organism. + XAO:0000437 + + + + + ncit:Death is an outcome + ncit + + + + + + + + + + + + + + + + + + + + + + + + + + + Any part or collection of parts of the central or peripheral nervous system. Parts may span both CNS and PNS. + Melissa Haendel + 2009-06-18T09:00:04Z + + + BIRNLEX:1157 + NCIT:C13040 + UMLS:C1518256 + part of nervous system + uberon + UBERON:0000073 + + + regional part of nervous system + + + + + Any part or collection of parts of the central or peripheral nervous system. Parts may span both CNS and PNS. + BIRNLEX:1157 + + + + + UMLS:C1518256 + ncithesaurus:Nervous_System_Part + + + + + part of nervous system + BIRNLEX:1157 + + + + + + + + + + + + + + + + + + + + + Anatomical cluster consisting of the skeletal elements and articular elements that are part of an individual subdivision of the organism. + UBERON:0010322 + + + FMA:85544 + NCIT:C34076 + UMLS:C1519343 + galen:ComplexSkeletalStructure + skeletal system subdivision + uberon + skeletal system part + UBERON:0000075 + + subdivision of skeletal system + + + + + + cjm + + + + + Anatomical cluster consisting of the skeletal elements and articular elements that are part of an individual subdivision of the organism. + + UBERONREF:0000003 + + + + + UMLS:C1519343 + ncithesaurus:Skeletal_System_Part + + + + + skeletal system subdivision + FMA:85544 + + + + + + + + + + + + + + + + + The surface (external) layer of ectoderm which begins to proliferate shortly after separation from the neuroectoderm. + merge with non-neural. In vertebrates, the ectoderm has three parts: external ectoderm (also known as surface ectoderm), the neurectoderm (neural crest, and neural tube) + (or external ectoderm) forms the following structures: Skin Epithelium of the mouth and nasal cavity saliavary glands, and glands of mouth and nasal cavity Enamel - as a side note dentin and dental pulp are formed from ectomesenchyme which is derived from ectoderm Epithelium of pineal and pituitary glands Lens and cornea of the eye Apical ectodermal ridge inducing development of the limb buds of the embryo. Sensory receptors in epidermis + + + EHDAA2:0001968 + EHDAA:1494 + EHDAA:350 + EHDAA:4784 + EHDAA:4790 + EHDAA:4796 + EHDAA:7860 + EMAPA:16096 + FMA:87656 + NCIT:C34309 + UMLS:C1515087 + surface (external) ectoderm + surface ectoderm + uberon + UBERON:0000076 + + external ectoderm + http://upload.wikimedia.org/wikipedia/commons/1/1d/Ectoderm.png + + + + + + EHDAA2 + + + + + + + + + + + EHDAA2 + + + + + The surface (external) layer of ectoderm which begins to proliferate shortly after separation from the neuroectoderm. + MGI:anna + MP:0012532 + + + + + UMLS:C1515087 + ncithesaurus:Surface_Ectoderm + + + + + surface ectoderm + MP:0012532 + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical structure that develops from the endoderm and the mesoderm. + Grouping term for query purposes. Notes that the developmental relationships are being refined such that most structures should develop in whole from at most one layer, but may have contributions from multiple + uberon + UBERON:0000077 + + mixed endoderm/mesoderm-derived structure + + + + + An anatomical structure that develops from the endoderm and the mesoderm. + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical structure that develops from the ectoderm, mesoderm and endoderm. + Grouping term for query purposes. Notes that the developmental relationships are being refined such that most structures should develop in whole from at most one layer, but may have contributions from multiple + uberon + UBERON:0000078 + + mixed ectoderm/mesoderm/endoderm-derived structure + + + + + An anatomical structure that develops from the ectoderm, mesoderm and endoderm. + + + + + + + + + + + + + + + + + stage succeeding embryo, including mature structure + In birds, the postnatal stage begins when the beak penetrates the shell (i.e., external pipping) (Brown et al. 1997) + BilaDO:0000003 + OGES:000010 + OGES:000014 + OGES:000024 + WBls:0000022 + WBls:0000093 + WBls:0000103 + postembryonic stage + post-hatching stage + uberon + postembryonic + UBERON:0000092 + post-embryonic stage + https://github.com/obophenotype/uberon/issues/344 + + + + + stage succeeding embryo, including mature structure + + + + + + + + + + + + + + + + Nonparenchymatous organ that primarily consists of dense connective tissue organized into a sheet which interconnects two or more organs, separates two or more body spaces from one another, or surrounds an organ or body part. Examples: interosseous membrane of forearm, obturator membrane, tympanic membrane, fibrous pericardium, fascia lata, dura mater. [FMA] + cjm + 2009-07-30T05:19:13Z + membrane + FMA:7145 + membrane of organ + uberon + UBERON:0000094 + membrane organ + + + + + + + + + + + FMA-def + + + + + Nonparenchymatous organ that primarily consists of dense connective tissue organized into a sheet which interconnects two or more organs, separates two or more body spaces from one another, or surrounds an organ or body part. Examples: interosseous membrane of forearm, obturator membrane, tympanic membrane, fibrous pericardium, fascia lata, dura mater. [FMA] + FMA:7145 + + + + + + + + + + + + + + + + + + + + + + + + + + + An entire span of an organism's life, commencing with the zygote stage and ending in the death of the organism. + FBdv:00000000 + HsapDv:0000001 + MmusDv:0000001 + OGES:000011 + ncithesaurus:Life + entire life cycle + entire lifespan + life + lifespan + uberon + UBERON:0000104 + + life cycle + https://github.com/obophenotype/uberon/issues/532 + + + + + An entire span of an organism's life, commencing with the zygote stage and ending in the death of the organism. + + + + + + + + + + + + + + + + A spatiotemporal region encompassing some part of the life cycle of an organism. + this class represents a proper part of the life cycle of an organism. The class 'life cycle' should not be placed here + the WBls class 'all stages' belongs here as it is the superclass of other WBls stages + we map the ZFS unknown stage here as it is logically equivalent to saying *some* life cycle stage + BILS:0000105 + EFO:0000399 + FBdv:00007012 + FMA:24120 + HsapDv:0000000 + MmusDv:0000000 + OlatDv:0000010 + PdumDv:0000090 + WBls:0000002 + XAO:1000000 + ZFS:0000000 + ZFS:0100000 + ncithesaurus:Developmental_Stage + developmental stage + stage + uberon + UBERON:0000105 + + + life cycle stage + + + + + A spatiotemporal region encompassing some part of the life cycle of an organism. + + + + + + + + + + + + + + + + + + + + + + + A stage at which the organism is a single cell produced by means of sexual reproduction. + As in all metazoans, eumetazoan development begins with a fertilized egg, or zygote.[well established][VHOG] + + BILS:0000106 + BilaDO:0000005 + EFO:0001322 + EHDAA:27 + FBdv:00005288 + NCIT:C12601 + PdumDv:0000100 + VHOG:0000745 + XAO:1000001 + ZFS:0000001 + 1-cell stage + fertilized egg stage + one cell stage + uberon + fertilized egg stage + one-cell stage + zygote + zygotum + UBERON:0000106 + + zygote stage + + + + + + A stage at which the organism is a single cell produced by means of sexual reproduction. + + + + + + As in all metazoans, eumetazoan development begins with a fertilized egg, or zygote.[well established][VHOG] + 2012-09-17 + VHOG:0000745 + VHOG + + ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.107 + + + + + fertilized egg stage + BTO:0000854 + + + + + one-cell stage + VHOG:0000745 + + + + + zygote + VHOG:0000745 + + + + + zygotum + + + + + + + + + + + + + + + + + + + + + + + + The first few specialized divisions of an activated animal egg; Stage consisting of division of cells in the early embryo. The zygotes of many species undergo rapid cell cycles with no significant growth, producing a cluster of cells the same size as the original zygote. The different cells derived from cleavage are called blastomeres and form a compact mass called the morula. Cleavage ends with the formation of the blastula. + + BILS:0000107 + BilaDO:0000006 + EFO:0001290 + FBdv:00000054 + MESH:A16.254.270 + MmusDv:0000004 + OGES:000015 + OGES:000020 + PdumDv:0000200 + XAO:1000004 + ZFS:0000046 + uberon + UBERON:0000107 + + cleavage stage + + + + + The first few specialized divisions of an activated animal egg; Stage consisting of division of cells in the early embryo. The zygotes of many species undergo rapid cell cycles with no significant growth, producing a cluster of cells the same size as the original zygote. The different cells derived from cleavage are called blastomeres and form a compact mass called the morula. Cleavage ends with the formation of the blastula. + + GO:0040016 + + + + + + + + + + + + + + + + + + + + + + An early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence. + consider adding a preceding stage 'morula stage' as part of cleavage + + BILS:0000108 + BilaDO:0000007 + EFO:0001282 + HsapDv:0000006 + MmusDv:0000007 + OGES:000003 + OGES:000016 + OGES:000021 + OpenCyc:Mx4rEetFnKP2EdqAAAACs4vPlg + WBls:0000005 + XAO:1000003 + ZFS:0000045 + uberon + UBERON:0000108 + + blastula stage + http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png + + + + + An early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence. + + + + + + + + + + + + + + + + + + + + + + + A stage defined by complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm. + BILS:0000109 + BilaDO:0000008 + EFO:0001296 + FBdv:00005317 + HsapDv:0000010 + MmusDv:0000013 + OGES:000004 + OGES:000019 + WBls:0000010 + XAO:1000005 + ZFS:0000047 + uberon + blastocystis trilaminaris stage + trilaminar blastocyst stage + trilaminar blastoderm stage + trilaminar disk stage + trilaminar germ stage + trilaminar stage + UBERON:0000109 + + gastrula stage + + + + + + + + + + + BILS + + + + + A stage defined by complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm. + GO:0007369 + + + + + blastocystis trilaminaris stage + + + + + + trilaminar blastocyst stage + + + + + + trilaminar blastoderm stage + + + + + + trilaminar disk stage + + + + + + trilaminar germ stage + + + + + + trilaminar stage + + + + + + + + + + + + + + + + + + + + + + + Staged defined by the formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system. + BILS:0000110 + BilaDO:0000009 + HsapDv:0000012 + MmusDv:0000017 + XAO:1000006 + uberon + UBERON:0000110 + neurula stage + https://github.com/obophenotype/uberon/issues/343 + + + + + Staged defined by the formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system. + GO:0001841 + + + + + + + + + + + + + + + + + + + + + + A stage at which the ectoderm, endoderm, and mesoderm develop into the internal organs of the organism. + + BILS:0000111 + BilaDO:0000010 + HsapDv:0000015 + MmusDv:0000018 + OGES:000005 + OGES:000032 + uberon + segmentation stage + UBERON:0000111 + organogenesis stage + https://github.com/obophenotype/uberon/issues/533 + + + + + A stage at which the ectoderm, endoderm, and mesoderm develop into the internal organs of the organism. + + + + + + + + + + + + + + + + A spatially aggregated collection of nerve cell bodies in the CNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections, and including nearby cells that share the same cell type, chemical phenotype, and connections. (CUMBO) + Anatomical structure consisting of a discrete aggregate of neuronal soma[GO][GO_REF:0000021]. + Proposed CUMBO def from MM: A subcortical part of the nervous system consisting of a relatively compact group of cells that is distinguishable histologically that share a commonality of cytoarchitecture, chemoarchitecturel and connectivity. (comments: I put in 'subcortical' because I don't think we consider either the cerebellar cortex or cerebral cortex to be nuclei. Some people distinguish between a nucleus and a laminar structure (see Wikipedia definition). However, there are structures identified as nuclei that are laminar, e.g., lateral geniculate nucleus, although they are not laminated in all species. Also, I put in 'relatively compact' and 'distiguishable by histology' because we have groups of cells, e.g., cholinergic cell groups, doparminergic cell groups that are related on the 3 criteria but which we don't tend to consider nuclei because they don't occupy an easily defined territory. But all is open to debate. + nucleus + + AEO:0000136 + FMA:83686 + NCIT:C13197 + NLX:28443 + nervous system nucleus + neuraxis nucleus + neuronal nucleus + nucleus of CNS + uberon + nucleus of neuraxis + UBERON:0000125 + + neural nucleus + + + + + A spatially aggregated collection of nerve cell bodies in the CNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections, and including nearby cells that share the same cell type, chemical phenotype, and connections. (CUMBO) + NLX:28443 + + + + + Anatomical structure consisting of a discrete aggregate of neuronal soma[GO][GO_REF:0000021]. + GO_REF:0000021 + + + + + neuraxis nucleus + FMA:83686 + + + + + neuronal nucleus + AEO:0000136 + + + + + nucleus of CNS + NLX:28443 + + + + + + + + + + + + + + + + uberon + UBERON:0000153 + anterior region of body + + + + + + lexical + + + + + + + + + uberon + UBERON:0000154 + posterior region of body + + + + + + lexical + + + + + + + + + Anatomical conduit that connects two adjacent body spaces (or a body space with the space surrounding the organism)[FMA,modified]. + in FMA, this is an anatomical conduit *space*, rather than anatomical conduit + anatomical ostium + ostium + + FMA:3724 + anatomical orifice + hilum + uberon + UBERON:0000161 + orifice + + + + + Anatomical conduit that connects two adjacent body spaces (or a body space with the space surrounding the organism)[FMA,modified]. + FMA:3724 + + + + + in FMA, this is an anatomical conduit *space*, rather than anatomical conduit + FMA + + + + + anatomical ostium + FMA:3724 + + + + + anatomical orifice + FMA:3724 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The proximal portion of the digestive tract, containing the oral cavity and bounded by the oral opening. In vertebrates, this extends to the pharynx and includes gums, lips, tongue and parts of the palate. Typically also includes the teeth, except where these occur elsewhere (e.g. pharyngeal jaws) or protrude from the mouth (tusks). + Cavity in which food is initially ingested and generally contains teeth, tongue and glands.[AAO] + Molecular and developmental cell lineage data suggest that the acoel mouth opening is homologous to the mouth of protostomes and deuterostomes and that the last common ancestor of the Bilateria (the 'urbilaterian') had only this single digestive opening.[well established][VHOG] + oral + some AOs place this as developing from the stomodeum but we weaken this to developmental contribution, as the mouth includes non-ectodermal derivatives + in FMA, the tongue, palate etc are part of the mouth which is itself a subdivision of the face. ZFA includes a separate class 'oral region' which is part of the mouth, but excludes tongue and lips + + + + AAO:0010355 + BTO:0001090 + BTO:0004698 + CALOHA:TS-1315 + EFO:0000825 + EHDAA2:0001326 + EHDAA:542 + EMAPA:16262 + FBbt:00003126 + FMA:49184 + GAID:75 + MA:0000341 + MA:0002474 + MAT:0000038 + MESH:D009055 + MIAA:0000038 + OpenCyc:Mx4rvVidh5wpEbGdrcN5Y29ycA + TADS:0000040 + TAO:0000547 + TAO:0000590 + TGMA:0000131 + VHOG:0000280 + VHOG:0000812 + XAO:0003029 + ZFA:0000547 + ZFA:0000590 + galen:Mouth + regio oralis + adult mouth + uberon + cavital oralis + cavitas oris + cavum oris + mouth cavity + oral region + oral vestibule + rima oris + stoma + stomatodaeum + trophic apparatus + vestibule of mouth + vestibulum oris + UBERON:0000165 + + + + + + mouth + https://github.com/obophenotype/uberon/issues/661 + http://upload.wikimedia.org/wikipedia/commons/0/06/Mouth_illustration-Otis_Archives.jpg + + + + + + the mouth contains structures such as jaw skeleton that may not strictly be considered tract parts + + + + + + + + + + + + + + + + exceptions in some taxa + + + + + The proximal portion of the digestive tract, containing the oral cavity and bounded by the oral opening. In vertebrates, this extends to the pharynx and includes gums, lips, tongue and parts of the palate. Typically also includes the teeth, except where these occur elsewhere (e.g. pharyngeal jaws) or protrude from the mouth (tusks). + + + + + + + Cavity in which food is initially ingested and generally contains teeth, tongue and glands.[AAO] + 2012-06-20 + AAO:0010355 + AAO + AAO:BJB + + + + + Molecular and developmental cell lineage data suggest that the acoel mouth opening is homologous to the mouth of protostomes and deuterostomes and that the last common ancestor of the Bilateria (the 'urbilaterian') had only this single digestive opening.[well established][VHOG] + 2012-09-17 + VHOG:0000812 + VHOG + + DOI:10.1038/nature07309 Hejnol A, Martindale MQ, Acoel development indicates the independent evolution of the bilaterian mouth and anus. Nature (2008) + + + + + in FMA, the tongue, palate etc are part of the mouth which is itself a subdivision of the face. ZFA includes a separate class 'oral region' which is part of the mouth, but excludes tongue and lips + FMA + + + + + regio oralis + BTO:0004698 + + + + + regio oralis + FMA:49184 + FMA:TA + + + + + + cavital oralis + + + + + + + cavitas oris + BTO:0001090 + + + + + cavum oris + BTO:0001090 + + + + + mouth cavity + BTO:0001090 + + + + + oral region + EHDAA2:0001326 + + + + + oral vestibule + BTO:0001090 + + + + + rima oris + BTO:0001090 + + + + + stomatodaeum + VHOG:0000812 + + + + + trophic apparatus + + + + + + vestibule of mouth + BTO:0001090 + + + + + vestibulum oris + BTO:0001090 + + + + + + + + + + + + + + + + The orifice that connects the mouth to the exterior of the body. + (...) mouth development is very similar in protostomes and 'basal' deuterostomes, whereas the chordate mouth seems to develop at a new position. Recent data for echinoderms and hemichordates further suggest that this change in mouth position may result from change in the influence of a conserved ectodermal patterning system on mouth development. It has been suggested that the mouths of vertebrates and urochordates may constitute a 'new' mouth.[well established][VHOG] + FMA:59806 + oral fissure + oral orifice + uberon + mouth + oral part of face + UBERON:0000166 + + + oral opening + + + + + + FMA + + + + + The orifice that connects the mouth to the exterior of the body. + + + + + + (...) mouth development is very similar in protostomes and 'basal' deuterostomes, whereas the chordate mouth seems to develop at a new position. Recent data for echinoderms and hemichordates further suggest that this change in mouth position may result from change in the influence of a conserved ectodermal patterning system on mouth development. It has been suggested that the mouths of vertebrates and urochordates may constitute a 'new' mouth.[well established][VHOG] + 2012-09-17 + VHOG:0000280 + VHOG + + DOI:10.1016/j.semcdb.2007.06.002 Christiaen L, Jaszczyszyn Y, Kerfant M, Kanob S, Thermes V, Joly JS, Evolutionary modification of mouth position in deuterostomes. Seminars in Cell and Developmental Biology (2007) + + + + + oral fissure + FMA:59806 + + + + + oral orifice + FMA:59806 + + + + + mouth + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Anatomical cavity at the start of the digestive tract that that is enclosed by the mouth. The boundaries and contents vary depending on the species. In vertebrates, the boundaries are the oral opening, the cheeks, the palate and (if present) the palatoglossal arch - if this is not present then the mouth and pharynx form the oropharyngeal cavity. The buccal cavity contains the teeth, tongue and palate (when present) + Anatomical cavity bounded anteriorly by the mouth and posteriorly by the derivatives of the branchial arches.[AAO] + The cavity of the mouth, bounded by the jaw bones and associated structures (muscles and mucosa). [TFD][VHOG] + Echinoderms, hemichordates, and chordates are called deuterostomes because the mouth arises not from the blastopore but from a second invagination at the anterior end of the larva that pushes in to connect with the archenteron.[well established][VHOG] + + + AAO:0000053 + AAO:0000960 + BSA:0000107 + CALOHA:TS-1315 + EFO:0001975 + EHDAA2:0001324 + EHDAA:6970 + EMAPA:17411 + EMAPA:18399 + EV:0100057 + FMA:20292 + HAO:0000669 + NCIT:C12421 + TAO:0001027 + TGMA:0000102 + UMLS:C0226896 + VHOG:0000188 + WBbt:0005255 + XAO:0000126 + ZFA:0001027 + buccal cavity + cavity of mouth + uberon + bucca + UBERON:0000167 + + + + oral cavity + + + + + Anatomical cavity at the start of the digestive tract that that is enclosed by the mouth. The boundaries and contents vary depending on the species. In vertebrates, the boundaries are the oral opening, the cheeks, the palate and (if present) the palatoglossal arch - if this is not present then the mouth and pharynx form the oropharyngeal cavity. The buccal cavity contains the teeth, tongue and palate (when present) + + + ISBN:0073040584 + + + + + Anatomical cavity bounded anteriorly by the mouth and posteriorly by the derivatives of the branchial arches.[AAO] + 2012-06-20 + AAO:0000960 + AAO + AAO:EJS + + + + + The cavity of the mouth, bounded by the jaw bones and associated structures (muscles and mucosa). [TFD][VHOG] + 2012-09-17 + VHOG:0000188 + VHOG + + + + + + + Echinoderms, hemichordates, and chordates are called deuterostomes because the mouth arises not from the blastopore but from a second invagination at the anterior end of the larva that pushes in to connect with the archenteron.[well established][VHOG] + 2012-09-17 + VHOG:0000188 + VHOG + + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.32 + + + + + UMLS:C0226896 + ncithesaurus:Oral_Cavity + + + + + buccal cavity + FMA:20292 + ISBN:0073040584 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A fluid that is composed of blood plasma and erythrocytes. + This class excludes blood analogues, such as the insect analog of blood. See UBERON:0000179 haemolymphatic fluid. + A complex mixture of cells suspended in a liquid matrix that delivers nutrients to cells and removes wastes. (Source: BioGlossary, www.Biology-Text.com)[TAO] + Highly specialized circulating tissue consisting of several types of cells suspended in a fluid medium known as plasma.[AAO] + relationship loss: subclass specialized connective tissue (AAO:0000571)[AAO] + Recent findings strongly suggest that the molecular pathways involved in the development and function of blood cells are highly conserved among vertebrates and various invertebrates phyla. (...) There is now good reason to believe that, in vertebrates and invertebrates alike, blood cell lineages diverge from a common type of progenitor cell, the hemocytoblast.[well established][VHOG] + + + + + AAO:0000046 + BTO:0000089 + CALOHA:TS-0079 + EFO:0000296 + EHDAA2:0000176 + EHDAA:418 + EMAPA:16332 + ENVO:02000027 + EV:0100047 + FMA:9670 + GAID:965 + MA:0000059 + MESH:D001769 + MIAA:0000315 + NCIT:C12434 + OpenCyc:Mx4rvVjI8JwpEbGdrcN5Y29ycA + TAO:0000007 + UMLS:C0005767 + VHOG:0000224 + XAO:0000124 + ZFA:0000007 + galen:Blood + portion of blood + vertebrate blood + uberon + whole blood + UBERON:0000178 + + + + + blood + + + + + + + + + + + + + + + + + + + + + + Bgee:AN + + + + + A fluid that is composed of blood plasma and erythrocytes. + + + + FMA:9670 + + + + + A complex mixture of cells suspended in a liquid matrix that delivers nutrients to cells and removes wastes. (Source: BioGlossary, www.Biology-Text.com)[TAO] + 2012-08-14 + TAO:0000007 + TAO + ZFIN:curator + + + + + Highly specialized circulating tissue consisting of several types of cells suspended in a fluid medium known as plasma.[AAO] + 2012-06-20 + AAO:0000046 + AAO + AAO:LAP + + + + + relationship loss: subclass specialized connective tissue (AAO:0000571)[AAO] + 2012-06-20 + AAO:0000046 + AAO + + + + + Recent findings strongly suggest that the molecular pathways involved in the development and function of blood cells are highly conserved among vertebrates and various invertebrates phyla. (...) There is now good reason to believe that, in vertebrates and invertebrates alike, blood cell lineages diverge from a common type of progenitor cell, the hemocytoblast.[well established][VHOG] + 2012-09-17 + VHOG:0000224 + VHOG + + DOI:10.1146/annurev.cellbio.22.010605.093317 Hartenstein V, Blood cells and blood cell development in the animal kingdom. Annual review of cell and developmental biology (2006) + + + + + UMLS:C0005767 + ncithesaurus:Blood + + + + + whole blood + BTO:0000089 + + + + + + + + + + + + + + + + + + + + + + + + + + Circulating fluid that is part of the hemolymphoid system. Blood, lymph, interstitial fluid or its analogs. + cjm + 2009-04-08T04:38:19Z + CARO:0000081 + uberon + blood or blood analog + circulating fluid + UBERON:0000179 + haemolymphatic fluid + + + + + Circulating fluid that is part of the hemolymphoid system. Blood, lymph, interstitial fluid or its analogs. + + + + + + + + + + + + + + + + + Dorsal part (roof region) of the telencephalon[GO]. + + In the anatomy of animals, an avian pallium is the dorsal telencephalon of a bird's brain. Pallium of avian species tend to be relatively large, comprising ~75% of the telencephalic volume. + In humans the cerebrum has three parts: the archipallium, the paleopallium and the neopallium. The developing telencephalon or forebrain is divided into pallium and subpallium. In amphibians, the cerebrum includes archipallium, paleopallium and some of the basal nuclei. Reptiles first developed a neopallium, which continued to develop in the brains of more recent species to become the neocortex of humans and Old World monkeys. In fish, the archipallium is the largest part of the cerebrum. Some researchers suggest the early archipallium gave rise to the human hippocampus + cjm + 2009-04-18T12:03:09Z + UBERON:0007333 + + + + + BTO:0003399 + DMBA:15903 + EFO:0003534 + TAO:0000505 + TAO:0007007 + ZFA:0000505 + area dorsalis telencephali + dorsal part of telencephalon + dorsal telencephalic area + dorsal telencephalon + uberon + UBERON:0000203 + + + pallium + https://sourceforge.net/p/obo/zebrafish-anatomy-zfa-term-requests/87 + + + + + Dorsal part (roof region) of the telencephalon[GO]. + + + GO:0021543 + ISBN:0471888893 + + + + + + + + + + + In the anatomy of animals, an avian pallium is the dorsal telencephalon of a bird's brain. Pallium of avian species tend to be relatively large, comprising ~75% of the telencephalic volume. + + NCBITaxon:8782 + + + + + In humans the cerebrum has three parts: the archipallium, the paleopallium and the neopallium. The developing telencephalon or forebrain is divided into pallium and subpallium. In amphibians, the cerebrum includes archipallium, paleopallium and some of the basal nuclei. Reptiles first developed a neopallium, which continued to develop in the brains of more recent species to become the neocortex of humans and Old World monkeys. In fish, the archipallium is the largest part of the cerebrum. Some researchers suggest the early archipallium gave rise to the human hippocampus + WP + + + + + area dorsalis telencephali + ZFA:0000505 + + + + + dorsal part of telencephalon + ISBN:0471888893 + + + + + dorsal telencephalic area + ZFA:0000505 + + + + + dorsal telencephalon + ZFA:0000505 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Organism at the blastula stage - an early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence. + TODO - check relationship with epiblast. Note in FMA this is not a subclass of embryo, but in uberon embryo is the whole organism from zygote onwards and thus includes the blastula + UBERON:0007011 + + BILA:0000059 + BTO:0000128 + GAID:1294 + MESH:A16.254.270.274 + OGEM:000006 + OpenCyc:Mx4rEetFnKP2EdqAAAACs4vPlg + blastula embryo + uberon + blastosphere + UBERON:0000307 + + blastula + http://upload.wikimedia.org/wikipedia/commons/c/c6/Blastulation.png + + + + + Organism at the blastula stage - an early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence. + + + + + + blastula embryo + BILA:0000059 + + + + + blastosphere + + + + + + + + + + + + + + + + + + + + + + + + + + + + The wall of the digestive tract. This encompasses all parts of the digestive tract with the exception of the lumen (cavity). + We model the digestive tract as consisting of two parts: the wall and the lumen. + BTO:0000547 + FMA:45653 + digestive tract wall + wall of digestive tract + wall of gut + uberon + wall of alimentary tract + UBERON:0000328 + gut wall + + + + + The wall of the digestive tract. This encompasses all parts of the digestive tract with the exception of the lumen (cavity). + + + + + + wall of gut + FMA:45653 + + + + + + + + + + + + + + + + + + + + + A lining of mostly endodermal origin, covered in epithelium, which is involved in absorption and secretion. They line various body cavities that are exposed to the external environment and internal organs. It is at several places continuous with skin: at the nostrils, the lips, the ears, the genital area, and the anus. The sticky, thick fluid secreted by the mucous membranes and gland is termed mucus. The term mucous membrane refers to where they are found in the body and not every mucous membrane secretes mucus[WP] + mucosal + FMA has mucosa vs region of mucosa; these are subtypes of Mucosa: Mucosa of gallbladder, tongue, .... The following are subtypes of Region of mucosa: Mucosa of zone of stomach, trachea, bronchus, dorsum of tongue.... Depends on whether the covered area is an organ or organ component. Uberon does not regard organ vs organ component as crucial distinction and thus collapses these into a single class deliberately + + + + AEO:0000199 + BTO:0000886 + CALOHA:TS-2031 + EHDAA2_RETIRED:0003234 + EV:0100382 + FMA:85355 + FMA:85358 + GAID:297 + MESH:D009092 + NCIT:C13166 + OpenCyc:Mx4rvmKNOpwpEbGdrcN5Y29ycA + UMLS:C0026724 + galen:Mucosa + mucosa of organ + mucosa of organ part + mucosal region + mucous membrane + organ mucosa + uberon + region of mucosa + tunica mucosa + UBERON:0000344 + + mucosa + http://upload.wikimedia.org/wikipedia/commons/4/4e/Ens.png + http://upload.wikimedia.org/wikipedia/en/thumb/4/4e/Ens.png/200px-Ens.png + + + + + A lining of mostly endodermal origin, covered in epithelium, which is involved in absorption and secretion. They line various body cavities that are exposed to the external environment and internal organs. It is at several places continuous with skin: at the nostrils, the lips, the ears, the genital area, and the anus. The sticky, thick fluid secreted by the mucous membranes and gland is termed mucus. The term mucous membrane refers to where they are found in the body and not every mucous membrane secretes mucus[WP] + + + + + + FMA has mucosa vs region of mucosa; these are subtypes of Mucosa: Mucosa of gallbladder, tongue, .... The following are subtypes of Region of mucosa: Mucosa of zone of stomach, trachea, bronchus, dorsum of tongue.... Depends on whether the covered area is an organ or organ component. Uberon does not regard organ vs organ component as crucial distinction and thus collapses these into a single class deliberately + FMA + + + + + UMLS:C0026724 + ncithesaurus:Mucosa + + + + + mucosa of organ + FMA:85355 + + + + + mucosa of organ part + FMA:85358 + + + + + mucosal region + FMA:85358 + + + + + mucous membrane + FMA:85355 + + + + + organ mucosa + FMA:85355 + + + + + region of mucosa + FMA:85358 + + + + + tunica mucosa + + + + + + + tunica mucosa + BTO:0000886 + + + + + + + + + + + + + + + + + + + + + + + + + + + A mucosa that is part of a pharynx [Automatically generated definition]. + UBERON:0003344 + + BTO:0001047 + EMAPA:26957 + FMA:55031 + MA:0003143 + mucosa of organ of pharynx + mucosa of pharynx + mucous membrane of pharynx + organ mucosa of pharynx + pharynx mucosa + pharynx mucosa of organ + pharynx mucous membrane + pharynx organ mucosa + tunica mucosa pharyngea + tunica mucosa pharyngis + uberon + mucous membrane of the pharynx + UBERON:0000355 + pharyngeal mucosa + + + + + A mucosa that is part of a pharynx [Automatically generated definition]. + OBOL:automatic + + + + + mucosa of organ of pharynx + OBOL:automatic + + + + + mucosa of pharynx + OBOL:automatic + + + + + mucous membrane of pharynx + FMA:55031 + + + + + mucous membrane of pharynx + OBOL:automatic + + + + + organ mucosa of pharynx + OBOL:automatic + + + + + pharynx mucosa + OBOL:automatic + + + + + pharynx mucosa of organ + OBOL:automatic + + + + + pharynx mucous membrane + OBOL:automatic + + + + + pharynx organ mucosa + OBOL:automatic + + + + + tunica mucosa pharyngea + FMA:55031 + FMA:TA + + + + + + mucous membrane of the pharynx + BTO:0001047 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The subdivision of the musculoskeletal system that consists of all the muscles of the body[VSAO, modified]. + consider whether this should be restricted to skeletal musculature. See https://github.com/obophenotype/uberon/issues/77 + Anatomical system that consists of the muscles of the body.[VSAO] + we place the MA term musculature here, rather than under uberon:musculature, as this seems more appropriate given the structure of MA + AAO:0000307 + BILA:0000088 + BTO:0001369 + BTO:0001485 + EFO:0000801 + EMAPA:35578 + FBbt:00005069 + FMA:72954 + MA:0002888 + MAT:0000025 + MIAA:0000025 + VSAO:0000033 + XAO:0004042 + muscle system + muscle system of body + muscular system + musculature system + set of all muscles + set of muscles of body + vertebrate muscular system + uberon + muskelsystem + UBERON:0000383 + + + musculature of body + + + + + The subdivision of the musculoskeletal system that consists of all the muscles of the body[VSAO, modified]. + VSAO:0000033 + + + + + Anatomical system that consists of the muscles of the body.[VSAO] + 2012-08-14 + VSAO:0000033 + VSAO + VSAO:curator + + + + + we place the MA term musculature here, rather than under uberon:musculature, as this seems more appropriate given the structure of MA + MA + + + + + muscular system + FMA:72954 + + + + + musculature system + BILA:0000088 + + + + + set of all muscles + FMA:72954 + + + + + set of muscles of body + FMA:72954 + + + + + vertebrate muscular system + BTO:0001369 + + + + + muskelsystem + BTO:0001485 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Tissue that surrounds the lens nucleus + + BTO:0001632 + CALOHA:TS-0542 + FMA:58970 + MESH:A09.371.509.225 + cortex of lens + uberon + UBERON:0000389 + lens cortex + + + + + Tissue that surrounds the lens nucleus + + + + + + cortex of lens + FMA:58970 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The core of the crystalline lens, surrounded by the cortex. + + BTO:0001633 + FMA:58971 + MESH:A09.371.509.670 + nucleus of lens + uberon + UBERON:0000390 + lens nucleus + + + + + The core of the crystalline lens, surrounded by the cortex. + BTO:0001633 + + + + + nucleus of lens + FMA:58971 + + + + + + + + + + + + + + + + + + + + + A gland in which the principal secretory cells are serous secreting cells. + glands that secrete watery albuminous material that often contains enzymes[MP:0008052]. + + BTO:0001837 + EMAPA:37950 + FMA:62889 + uberon + UBERON:0000409 + + + serous gland + http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray1021.png + + + + + A gland in which the principal secretory cells are serous secreting cells. + + + + + + + glands that secrete watery albuminous material that often contains enzymes[MP:0008052]. + MP:0008052 + + + + + EMAPA:37950 + MA:th + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical wall that is part of an artery [Automatically generated definition]. + BTO:0002009 + FMA:14155 + galen:ArterialWall + arterial wall + wall of artery + uberon + UBERON:0000415 + artery wall + + + + + An anatomical wall that is part of an artery [Automatically generated definition]. + OBOL:automatic + + + + + arterial wall + FMA:14155 + + + + + wall of artery + FMA:14155 + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of organism substance that is produced by exocrine glands. + BTO has two distunct classes, with exocrine glandular secretion a subtype of secretion - however, all examples in BTO directly under secretion appear to be exocrine gland secretions + UBERON:0006540 + secretion + + AEO:0001005 + BTO:0002977 + BTO:0002979 + EMAPA:36535 + FMA:9675 + MA:0002504 + MESH:D012634 + NCIT:C34062 + UMLS:C1516992 + galen:Secretion + bodily secretion + exocrine gland fluid/secretion + secreted substance + uberon + exocrine gland fluid + exocrine gland fluid or secretion + exocrine gland secretion + external secretion + UBERON:0000456 + secretion of exocrine gland + + + + + A portion of organism substance that is produced by exocrine glands. + + + + + + BTO has two distunct classes, with exocrine glandular secretion a subtype of secretion - however, all examples in BTO directly under secretion appear to be exocrine gland secretions + BTO + + + + + secretion + FMA:9675 + + + + + UMLS:C1516992 + ncithesaurus:Exocrine_Gland_Fluid_or_Secretion + + + + + bodily secretion + MESH:D012634 + + + + + exocrine gland fluid/secretion + MA:0002504 + + + + + external secretion + BTO:0002977 + + + + + + + + + + + + + + + Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body. + AAO:0010839 + AEO:0000004 + BILA:0000004 + CALOHA:TS-2101 + CARO:0000004 + EHDAA2:0003004 + EMAPA:35178 + FBbt:00007019 + FMA:9669 + HAO:0000004 + MA:0002450 + NCIT:C13236 + SPD:0000008 + TAO:0001487 + TGMA:0001824 + VHOG:0001726 + XAO:0004001 + ZFA:0001487 + galen:BodySubstance + body fluid or substance + body substance + organism substance + portion of body substance + portion of organism substance + uberon + UBERON:0000463 + + + organism substance + + + + + + + + + + + this relationship may be too strong and may be weakened in future + + + + + Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body. + + + + + + body fluid or substance + MA:0002450 + + + + + body substance + FMA:9669 + + + + + organism substance + CARO:0000004 + + + + + portion of body substance + FMA:9669 + + + + + portion of organism substance + ZFA:0001487 + + + + + + + + + + + + + + + Non-material anatomical entity of three dimensions, that is generated by morphogenetic or other physiologic processes; is surrounded by one or more anatomical structures; contains one or more organism substances or anatomical structures. + lumen + space + + AAO:0010110 + AEO:0000005 + BILA:0000005 + CARO:0000005 + EHDAA2:0003005 + FBbt:00007017 + FMA:5897 + HAO:0000005 + NCIT:C94478 + TAO:0001668 + TGMA:0001825 + UMLS:C0524461 + VHOG:0001728 + XAO:0003190 + ZFA:0001643 + lumen space + uberon + anatomical spaces + UBERON:0000464 + + anatomical space + + + + + Non-material anatomical entity of three dimensions, that is generated by morphogenetic or other physiologic processes; is surrounded by one or more anatomical structures; contains one or more organism substances or anatomical structures. + + + + + + UMLS:C0524461 + ncithesaurus:Lumen_Space + + + + + anatomical spaces + ZFA:0001643 + + + + + + + + + + Anatomical entity that has mass. + AAO:0010264 + AEO:0000006 + BILA:0000006 + CARO:0000006 + EHDAA2:0003006 + FBbt:00007016 + FMA:67165 + HAO:0000006 + TAO:0001836 + TGMA:0001826 + VHOG:0001721 + uberon + UBERON:0000465 + + material anatomical entity + + + + + Anatomical entity that has mass. + + + + + + + + + + Anatomical entity that has no mass. + AAO:0010265 + AEO:0000007 + BILA:0000007 + CARO:0000007 + EHDAA2:0003007 + FBbt:00007015 + FMA:67112 + HAO:0000007 + TAO:0001835 + TGMA:0001827 + VHOG:0001727 + immaterial physical anatomical entity + uberon + UBERON:0000466 + + immaterial anatomical entity + + + + + Anatomical entity that has no mass. + + + + + + immaterial physical anatomical entity + FMA:67112 + + + + + + + + + + + + + + + + + + + + + + + + + + + Multicellular, connected anatomical structure that has multiple organs as parts and whose parts work together to achieve some shared function. + system + + + + AAO:0000007 + AEO:0000011 + BILA:0000011 + BIRNLEX:14 + BSA:0000049 + CALOHA:TS-2088 + CARO:0000011 + EHDAA2:0003011 + EHDAA:392 + EMAPA:16103 + EV:0100000 + FBbt:00004856 + FMA:7149 + HAO:0000011 + MA:0000003 + NCIT:C12919 + OpenCyc:Mx4rCWM0QCtDEdyAAADggVbxzQ + TAO:0001439 + TGMA:0001831 + UMLS:C0460002 + VHOG:0001725 + WBbt:0005746 + WBbt:0005763 + XAO:0003002 + ZFA:0001439 + galen:AnatomicalSystem + body system + connected anatomical system + organ system + uberon + anatomical systems + UBERON:0000467 + + + + anatomical system + + + + + + Multicellular, connected anatomical structure that has multiple organs as parts and whose parts work together to achieve some shared function. + CARO:0000011 + + + + + system + GO:0048731 + + + + + UMLS:C0460002 + ncithesaurus:Organ_System + + + + + body system + BIRNLEX:14 + + + + + connected anatomical system + CARO:0000011 + + + + + anatomical systems + ZFA:0001439 + + + + + + + + + + Anatomical structure that is an individual member of a species and consists of more than one cell. + TODO - split body and mc organism? body continues after death stage + organismal + organism + + + AAO:0010026 + AEO:0000191 + BILA:0000012 + BIRNLEX:18 + BSA:0000038 + BTO:0000042 + CARO:0000012 + EFO:0002906 + EHDAA2:0003103 + EHDAA2:0003191 + EHDAA:1 + EMAPA:25765 + EV:0100016 + FBbt:00000001 + FMA:256135 + HAO:0000012 + NCIT:C13041 + TADS:0000001 + TAO:0001094 + TGMA:0001832 + VHOG:0000671 + WBbt:0007833 + XAO:0003004 + ZFA:0001094 + galen:Organism + ncithesaurus:Whole_Organism + multi-cellular organism + animal + uberon + Koerper + body + whole body + whole organism + UBERON:0000468 + + + + + multicellular organism + + + + + Anatomical structure that is an individual member of a species and consists of more than one cell. + + + CARO:0000012 + + + + + organism + FBbt:00000001 + VHOG:0000671 + WBbt:0007833 + + + + + multi-cellular organism + CARO:0000012 + + + + + animal + BTO:0000042 + + + + + Koerper + BTO:0001489 + + + + + body + AEO:0000103 + BIRNLEX:18 + FMA:256135 + NCIT:C13041 + + + + + whole body + BTO:0001489 + + + + + whole organism + FBbt:00000001 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Anatomical structure which is a subdivision of a whole organism, consisting of components of multiple anatomical systems, largely surrounded by a contiguous region of integument. + Reflects CARO2. todo - check the inclusion of FMA 'cardinal body part here', and check child terms for consistency + + + AAO:0010053 + AEO:0000032 + BILA:0000032 + BIRNLEX:7 + CALOHA:TS-2084 + CARO:0000032 + EFO:0000808 + EHDAA2:0003032 + EMAPA:36031 + FBbt:00007009 + FMA:7153 + HAO:0000032 + MA:0002433 + MAT:0000293 + MESH:D001829 + MIAA:0000293 + NCIT:C32221 + OpenCyc:Mx4rvViAHJwpEbGdrcN5Y29ycA + TAO:0001308 + TGMA:0001840 + UMLS:C0229962 + VHOG:0001758 + XAO:0003013 + ZFA:0001308 + galen:BodyPart + anatomic region + uberon + body part + body region + cardinal body part + UBERON:0000475 + + + + + organism subdivision + + + + + + CARO + + + + + Anatomical structure which is a subdivision of a whole organism, consisting of components of multiple anatomical systems, largely surrounded by a contiguous region of integument. + + CARO:0000032 + CARO:DOS + + + + + UMLS:C0229962 + ncithesaurus:Body_Part + + + + + anatomic region + MA:0002433 + + + + + body region + FMA:7153 + + + + + cardinal body part + FMA:7153 + + + + + + + + + + Anatomical structure that consists of cell parts and cell substances and together does not constitute a cell or a tissue. + AAO:0010268 + AEO:0000040 + BILA:0000040 + CARO:0000040 + EHDAA2:0003040 + FBbt:00007013 + FMA:63863 + HAO:0000040 + TAO:0000382 + TGMA:0001841 + XAO:0003162 + ZFA:0000382 + uberon + acellular anatomical structures + UBERON:0000476 + + acellular anatomical structure + + + + + + CARO + + + + + Anatomical structure that consists of cell parts and cell substances and together does not constitute a cell or a tissue. + + + + + + acellular anatomical structures + ZFA:0000382 + + + + + + + + + + Anatomical group that has its parts adjacent to one another. + Will be obsoleted in CARO v2 [https://github.com/obophenotype/caro/issues/3] + AAO:0010009 + AEO:0000041 + BILA:0000041 + CARO:0000041 + EHDAA2:0003041 + FBbt:00007277 + FMA:49443 + HAO:0000041 + TADS:0000605 + TAO:0001478 + TGMA:0001842 + VHOG:0001737 + XAO:0003160 + ZFA:0001478 + uberon + UBERON:0000477 + + anatomical cluster + + + + + Anatomical group that has its parts adjacent to one another. + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A multicellular anatomical structure that is associated with an embryo and derived from the zygote from which it develops, but which does not contribute to the embryo proper or to structures that are part of the same organism after embryogenesis. + + + AAO:0010020 + AEO:0000042 + BILA:0000042 + CALOHA:TS-2119 + CARO:0000042 + EHDAA2:0003042 + EHDAA:46 + FBbt:00005835 + FMA:85537 + HAO:0000042 + NCIT:C34055 + TAO:0000020 + TGMA:0001843 + UMLS:C1282438 + VHOG:0000292 + XAO:0004005 + ZFA:0000020 + extra-embryonic structure + uberon + extraembryonic structures + extraembryonic tissue + UBERON:0000478 + + + + see also conceptus extraembryonic component in EHDAA2. + extraembryonic structure + + + + + A multicellular anatomical structure that is associated with an embryo and derived from the zygote from which it develops, but which does not contribute to the embryo proper or to structures that are part of the same organism after embryogenesis. + + + CARO:DOS + + + + + UMLS:C1282438 + ncithesaurus:Extraembryonic_Structure + + + + + extraembryonic structures + ZFA:0000020 + + + + + + + + + + + + + + + + Multicellular anatomical structure that consists of many cells of one or a few types, arranged in an extracellular matrix such that their long-range organisation is at least partly a repetition of their short-range organisation. + changed label and definition to reflect CARO2 + + AAO:0000607 + AAO:0010054 + AEO:0000043 + BILA:0000043 + BIRNLEX:19 + CALOHA:TS-2090 + CARO:0000043 + EHDAA2:0003043 + EMAPA:35868 + FBbt:00007003 + FMA:9637 + HAO:0000043 + MA:0003002 + MESH:D014024 + NCIT:C12801 + TAO:0001477 + TGMA:0001844 + UMLS:C0040300 + VHOG:0001757 + WBbt:0005729 + XAO:0003040 + ZFA:0001477 + galen:Tissue + portion of tissue + tissue portion + simple tissue + uberon + UBERON:0000479 + + + tissue + + + + + + CARO + + + + + Multicellular anatomical structure that consists of many cells of one or a few types, arranged in an extracellular matrix such that their long-range organisation is at least partly a repetition of their short-range organisation. + CARO:0000043 + + + + + UMLS:C0040300 + ncithesaurus:Tissue + + + + + portion of tissue + CARO:0000043 + + + + + simple tissue + AEO:0000043 + + + + + + + + + + + + + + + Anatomical structure that has as its parts two or more portions of tissue of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona-fide boundaries from other distinct structural units of different types. + AAO:0010048 + AEO:0000055 + BILA:0000055 + CARO:0000055 + EHDAA2:0003055 + FBbt:00007010 + HAO:0000055 + TAO:0001488 + TGMA:0001847 + VHOG:0001762 + XAO:0003037 + ZFA:0001488 + uberon + multi-tissue structures + UBERON:0000481 + + multi-tissue structure + + + + + + CARO + + + + + Anatomical structure that has as its parts two or more portions of tissue of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona-fide boundaries from other distinct structural units of different types. + + CARO:0000055 + + + + + multi-tissue structures + ZFA:0001488 + + + + + + + + + + + + + + + + + + + + + + + + Portion of tissue, that consists of one or more layers of epithelial cells connected to each other by cell junctions and which is underlain by a basal lamina. Examples: simple squamous epithelium, glandular cuboidal epithelium, transitional epithelium, myoepithelium[CARO]. + The two basic types of metazoan tissue are epithelial and connective. The simplest metazoans, and developmental stages of many primitive invertebrates, consist solely of these two layers. Thus, epithelial and connective tissues may be the primary (original) tissues of metazoans, and both are important in the functional organization of animals.[well established][VHOG] + epithelial + + + + AAO:0000144 + AAO:0010055 + AEO:0000066 + BILA:0000066 + BTO:0000416 + CALOHA:TS-0288 + CARO:0000066 + EHDAA2:0003066 + EMAPA:32738 + FBbt:00007005 + FMA:9639 + GAID:402 + HAO:0000066 + MA:0003060 + MESH:D004848 + NCIT:C12710 + TAO:0001486 + UMLS:C0014609 + VHOG:0000387 + XAO:0003045 + ZFA:0001486 + epithelial tissue + portion of epithelium + uberon + UBERON:0000483 + + + + epithelium + Tkanka:nablonkowa.png + + + + + Portion of tissue, that consists of one or more layers of epithelial cells connected to each other by cell junctions and which is underlain by a basal lamina. Examples: simple squamous epithelium, glandular cuboidal epithelium, transitional epithelium, myoepithelium[CARO]. + + + + + + + The two basic types of metazoan tissue are epithelial and connective. The simplest metazoans, and developmental stages of many primitive invertebrates, consist solely of these two layers. Thus, epithelial and connective tissues may be the primary (original) tissues of metazoans, and both are important in the functional organization of animals.[well established][VHOG] + 2012-09-17 + VHOG:0000387 + VHOG + + ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.59 + + + + + UMLS:C0014609 + ncithesaurus:Epithelium + + + + + portion of epithelium + FMA:9639 + + + + + + + + + + Unilaminar epithelium that consists of a single layer of cuboidal cells. + needs to be synchronized with CL - there is no distinct cuboidal cell in CL + + + AAO:0010064 + AEO:0000067 + BILA:0000067 + CARO:0000067 + EHDAA2:0003067 + FMA:45566 + HAO:0000067 + NCIT:C33553 + TAO:0001497 + UMLS:C0836134 + XAO:0004009 + ZFA:0001497 + epithelium simplex cuboideum + uberon + simple cuboidal epithelia + UBERON:0000484 + + + simple cuboidal epithelium + http://upload.wikimedia.org/wikipedia/commons/d/d0/Gray1133.png + + + + + Unilaminar epithelium that consists of a single layer of cuboidal cells. + + + + + + + UMLS:C0836134 + ncithesaurus:Simple_Cuboidal_Epithelium + + + + + simple cuboidal epithelia + ZFA:0001497 + + + + + + + + + + Epithelium which consists of more than one layer of epithelial cells that may or may not be in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, ciliated stratified columnar epithelium.[FMA] + Epithelium that consists of more than one layer of epithelial cells.[CARO] + + + + AAO:0010059 + AEO:0000069 + BILA:0000069 + BTO:0002074 + CARO:0000069 + EHDAA2:0003069 + FMA:45562 + HAO:0000069 + NCIT:C33622 + TAO:0001494 + UMLS:C0682575 + XAO:0004006 + ZFA:0001494 + stratified epithelium + uberon + laminated epithelium + UBERON:0000486 + + + multilaminar epithelium + + + + + Epithelium which consists of more than one layer of epithelial cells that may or may not be in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, ciliated stratified columnar epithelium.[FMA] + + + FMA:FMA + + + + + Epithelium that consists of more than one layer of epithelial cells.[CARO] + 2012-06-20 + CARO:0000069 + CARO + + FMA:45562 + + + + + UMLS:C0682575 + ncithesaurus:Stratified_Epithelium + + + + + laminated epithelium + BTO:0002074 + + + + + + + + + + Unilaminar epithelium which consists of a single layer of squamous cells. Examples: pulmonary alveolar epithelium, endothelium.[FMA] + Unilaminar epithelium that consists of a single layer of squamous cells.[CARO] + + + AAO:0010066 + AEO:0000070 + BILA:0000070 + BTO:0002073 + CARO:0000070 + EHDAA2:0003070 + FMA:45565 + HAO:0000070 + NCIT:C13178 + TAO:0001498 + UMLS:C0836133 + XAO:0004010 + ZFA:0001498 + epithelium simplex squamosum + uberon + simple squamous epithelia + UBERON:0000487 + + + simple squamous epithelium + Illu:epithelium.jpg + + + + + Unilaminar epithelium which consists of a single layer of squamous cells. Examples: pulmonary alveolar epithelium, endothelium.[FMA] + + + FMA:45565 + + + + + Unilaminar epithelium that consists of a single layer of squamous cells.[CARO] + 2012-06-20 + CARO:0000070 + CARO + + FMA:45565 + + + + + UMLS:C0836133 + ncithesaurus:Simple_Squamous_Epithelium + + + + + simple squamous epithelia + ZFA:0001498 + + + + + + + + + + Epithelium that consists of epithelial cells not arranged in one ore more layers. + AAO:0010057 + AEO:0000071 + BILA:0000071 + CARO:0000071 + EHDAA2:0003071 + FMA:61741 + HAO:0000071 + TAO:0001493 + XAO:0004004 + ZFA:0001493 + heterogenous epithelium + uberon + atypical epithelia + UBERON:0000488 + + atypical epithelium + + + + + Epithelium that consists of epithelial cells not arranged in one ore more layers. + + + + + + atypical epithelia + ZFA:0001493 + + + + + + + + + + + + + + + + + + + + + + + + + + + Compound organ that contains one or more macroscopic anatomical spaces. + this class was introduced for consistency with CARO, however, it has yet to be used in this or other ontologies. It may be retired in the future + AAO:0010016 + AEO:0000072 + BILA:0000072 + CARO:0000072 + EHDAA2:0003072 + FMA:55671 + HAO:0000072 + TAO:0001490 + TGMA:0001857 + VHOG:0001730 + XAO:0003165 + ZFA:0001490 + cavitated organ + uberon + cavitated compound organs + UBERON:0000489 + + + cavitated compound organ + + + + + cavitated organ + FMA:55671 + + + + + cavitated compound organs + ZFA:0001490 + + + + + + Compound organ that contains one or more macroscopic anatomical spaces. + + + + + + + + + + Epithelium which consists of a single layer of epithelial cells. Examples: endothelium, mesothelium, glandular squamous epithelium.[FMA] + consider adding disjointness axiom between unilaminar and multilaminar - but note that this will render EHDAA2:0003244 (chorionic trophoblast) unsatisfiable + Epithelium that consists of a single layer of epithelial cells.[CARO] + + + AAO:0010062 + AEO:0000073 + BILA:0000073 + BTO:0002073 + CARO:0000073 + EHDAA2:0003073 + FMA:45561 + HAO:0000073 + NCIT:C33554 + TAO:0001495 + UMLS:C0682574 + XAO:0004007 + ZFA:0001495 + simple epithelium + uberon + unilaminar epithelia + UBERON:0000490 + + unilaminar epithelium + + + + + Epithelium which consists of a single layer of epithelial cells. Examples: endothelium, mesothelium, glandular squamous epithelium.[FMA] + + FMA:45561 + + + + + Epithelium that consists of a single layer of epithelial cells.[CARO] + 2012-06-20 + CARO:0000073 + CARO + + FMA:45561 + + + + + UMLS:C0682574 + ncithesaurus:Simple_Epithelium + + + + + simple epithelium + FMA:45561 + + + + + unilaminar epithelia + ZFA:0001495 + + + + + + + + + + + + + + + + + + + + + + + + + + + + Subdivision of trunk that lies between the head and the abdomen. + note that we use the slightly verbose term 'thoracic segment of trunk' to avoid confusuon with insect thorax. todo - taxonomic constraints. Also, in FMA 'thorax' is a synonym for chest + + + EMAPA:35862 + FMA:259209 + MA:0000022 + thorax + uberon + anterior subdivision of trunk + upper body + upper trunk + UBERON:0000915 + + thoracic segment of trunk + + + + + + FMA + + + + + Subdivision of trunk that lies between the head and the abdomen. + + + + + + thorax + MA:0000022 + + + + + upper trunk + FMA:259209 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Anatomical entity that comprises the organism in the early stages of growth and differentiation that are characterized by cleavage, the laying down of fundamental tissues, and the formation of primitive organs and organ systems. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant. + embryonic + Obsoleted in ZFA. Note that embryo is not classified as an embryonic structure - an embryonic structure is only the parts of an embryo + + + + + AAO:0011035 + AEO:0000169 + BILA:0000056 + BSA:0000039 + BTO:0000379 + CALOHA:TS-0229 + EFO:0001367 + EHDAA2:0000002 + EHDAA2_RETIRED:0003236 + EHDAA:38 + EMAPA:16039 + FBbt:00000052 + FMA:69068 + GAID:963 + MAT:0000226 + MESH:D004622 + MIAA:0000019 + NCIT:C28147 + OGEM:000001 + OpenCyc:Mx4rwP1ceZwpEbGdrcN5Y29ycA + UMLS:C0013935 + VHOG:0001766 + XAO:0000113 + ZFA:0000103 + embryonic organism + uberon + developing organism + developmental tissue + UBERON:0000922 + + + + + embryo + https://github.com/obophenotype/uberon/issues/503 + Wrinkledfrog:embryos.jpg + + + + + Anatomical entity that comprises the organism in the early stages of growth and differentiation that are characterized by cleavage, the laying down of fundamental tissues, and the formation of primitive organs and organ systems. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant. + + BTO:0000379 + FB:FBrf0039741 + FB:FBrf0041814 + GO:0009790 + + + + + Obsoleted in ZFA. Note that embryo is not classified as an embryonic structure - an embryonic structure is only the parts of an embryo + ZFA + + + + + UMLS:C0013935 + ncithesaurus:Embryo + + + + + embryonic organism + BILA:0000056 + + + + + developing organism + BILA:0000056 + + + + + + + + + A layer of cells produced during the process of gastrulation during the early development of the animal embryo, which is distinct from other such layers of cells, as an early step of cell differentiation. The three types of germ layers are the endoderm, ectoderm, and mesoderm. + The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG] + embryonic tissue + + + + AAO:0000480 + BILA:0000035 + BTO:0000556 + EMAPA:36033 + FBbt:00000110 + FMA:69069 + GAID:1303 + MESH:A16.254.425 + NCIT:C12950 + NCIT:C54105 + TAO:0001122 + UMLS:C0920502 + UMLS:C1708239 + VHOG:0001223 + XAO:0003011 + ZFA:0001122 + germinal layer + primary germ layer + uberon + embryonic germ layer + embryonic germ layers + UBERON:0000923 + + + Classically the germ layers are ectoderm, mesoderm and endoderm. Alternatively: primary = ectoderm, endoderm; secondary=mesoderm; tertiary=dorsal mesoderm, NC[https://github.com/obophenotype/uberon/wiki/The-neural-crest] + germ layer + + + + + A layer of cells produced during the process of gastrulation during the early development of the animal embryo, which is distinct from other such layers of cells, as an early step of cell differentiation. The three types of germ layers are the endoderm, ectoderm, and mesoderm. + + + + + + + The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG] + 2012-09-17 + VHOG:0001223 + VHOG + + ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) Limb development and evolution, p.722 + + + + + embryonic tissue + FMA:69069 + + + + + UMLS:C0920502 + ncithesaurus:Embryonic_Tissue + + + + + UMLS:C1708239 + ncithesaurus:Germinal_Layer + + + + + germinal layer + ncithesaurus:Germinal_Layer + + + + + primary germ layer + GO:0001704 + ZFA:0001122 + + + + + + + + + + + + + + + + + + + + + Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue. + Primary germ layer that is the outer of the embryonic germ layers and gives rise to epidermis and neural tissue.[AAO] + The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG] + ectodermal + + + + AAO:0000137 + BILA:0000036 + BTO:0000315 + CALOHA:TS-0216 + EFO:0000414 + EHDAA2:0000428 + EMAPA:16069 + EV:0100003 + FBbt:00000111 + FMA:69070 + GAID:1304 + MAT:0000155 + MAT:0000173 + MESH:A16.254.425.273 + MIAA:0000173 + NCIT:C12703 + TAO:0000016 + UMLS:C0013574 + VHOG:0000153 + XAO:0000001 + ZFA:0000016 + embryonic ectoderm + uberon + UBERON:0000924 + + + + + ectoderm + http://upload.wikimedia.org/wikipedia/commons/1/19/Gray32.png + + + + + + + + + + + Bgee:AN + + + + + Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue. + + + + + + Primary germ layer that is the outer of the embryonic germ layers and gives rise to epidermis and neural tissue.[AAO] + 2012-06-20 + AAO:0000137 + AAO + AAO:EJS + + + + + The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG] + 2012-09-17 + VHOG:0000153 + VHOG + + ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) Limb development and evolution, p.722 + + + + + UMLS:C0013574 + ncithesaurus:Ectoderm + + + + + embryonic ectoderm + VHOG:0000153 + + + + + + + + + + + + + + + + + + + + + Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut. + The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG] + endodermal + + + + AAO:0000139 + BILA:0000038 + BTO:0000800 + CALOHA:TS-0273 + EFO:0002545 + EHDAA2:0000436 + EMAPA:16062 + EV:0100005 + FBbt:00000125 + FMA:69071 + GAID:1305 + MAT:0000175 + MESH:A16.254.425.407 + MIAA:0000175 + NCIT:C12706 + TAO:0000017 + UMLS:C0014144 + VHOG:0000154 + XAO:0000090 + ZFA:0000017 + uberon + entoderm + UBERON:0000925 + + + + + endoderm + http://upload.wikimedia.org/wikipedia/commons/c/c0/Endoderm2.png + http://upload.wikimedia.org/wikipedia/commons/d/df/Gray10.png + + + + + + + + + + + Bgee:AN + + + + + Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut. + + + + + + The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG] + 2012-09-17 + VHOG:0000154 + VHOG + + ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) Limb development and evolution, p.722 + + + + + UMLS:C0014144 + ncithesaurus:Endoderm + + + + + entoderm + + + + + + + + + + + + + + + + + + + + + + + The middle germ layer of the embryo, between the endoderm and ectoderm. + Primary germ layer that is the middle of the embryonic germ layers.[AAO] + The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG] + mesodermal + sponges do not seem to have a mesoderm and accordingly Amphimedon lacks transcription factors involved in mesoderm development (Fkh, Gsc, Twist, Snail)[http://www.nature.com/nature/journal/v466/n7307/full/nature09201.html]. Mesoderm may not be homologous across verteberates + UBERON:0003263 + + + + AAO:0000304 + BILA:0000037 + BTO:0000839 + CALOHA:TS-0623 + EFO:0001981 + EHDAA2:0001128 + EHDAA:124 + EHDAA:160 + EHDAA:183 + EMAPA:16083 + EV:0100006 + FBbt:00000126 + FMA:69072 + GAID:522 + MAT:0000174 + MESH:A16.254.425.660 + MIAA:0000174 + NCIT:C12750 + TAO:0000041 + UMLS:C0025485 + VHOG:0000152 + XAO:0000050 + ZFA:0000041 + uberon + embryonic mesoderm + entire mesoderm + mesodermal mantle + UBERON:0000926 + + + + + mesoderm + http://upload.wikimedia.org/wikipedia/commons/e/e8/Mesoderm.png + + + + + + sometimes not considered primary + + + + + + + + + + + Bgee:AN + + + + + The middle germ layer of the embryo, between the endoderm and ectoderm. + + + + + + Primary germ layer that is the middle of the embryonic germ layers.[AAO] + 2012-06-20 + AAO:0000304 + AAO + AAO:EJS + + + + + The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG] + 2012-09-17 + VHOG:0000152 + VHOG + + ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) Limb development and evolution, p.722 + + + + + sponges do not seem to have a mesoderm and accordingly Amphimedon lacks transcription factors involved in mesoderm development (Fkh, Gsc, Twist, Snail)[http://www.nature.com/nature/journal/v466/n7307/full/nature09201.html]. Mesoderm may not be homologous across verteberates + + + + + + UMLS:C0025485 + ncithesaurus:Mesoderm + + + + + embryonic mesoderm + VHOG:0000152 + + + + + entire mesoderm + + + + + + + + + + + + + + + + + + + + + + + + Anterior part of the embryonic digestive tract that develops into a mouth. The stomodeum includes as parts an invagination of the ectoderm and the stomodeal cavity. + consider indicating location. e.g. anterior. Note some AOs place this as part of oral opening, but it's not clear when this structure comes into existence + Anterior part of the embryonic alimentary canal formed as an invagination of the ectoderm; the future mouth.[TAO] + the primordial mouth region of the developing head, initially a midline ectodermal depression between the forebrain bulge (cranially) and the heart bulge (caudally) and between the maxillary and mandibular components of the first pharyngeal arch; the stomodeum is separated from the anterior end of the foregut by the buccopharyngeal membrane; the mouth is developed partly from the stomodeum, and partly from the floor of the anterior portion of the foregut; the lips, teeth, and gums are formed from the walls of the stomodeum, but the tongue is developed in the floor of the pharynx + stomodeal + This class groups together disparate structures as all being the anterior part of the early metazoan digestive tract and precursor of the mouth. However, the developmental processes vary, so this class may be split in future. E.g. in mammals it is a rostral depression surrounded by prominences. Outgrowth of the prominences produces a stomodeal cavity. + stomodeal-hypophyseal primordium + + + BTO:0004224 + EHDAA2:0001929 + EMAPA:16263 + FBbt:00000439 + FMA:295846 + NCIT:C34306 + TAO:0001290 + TGMA:0000135 + UMLS:C1514977 + XAO:0000269 + ZFA:0001290 + mouth primordium + primitive oral cavity + stomatodeum + stomodaeum + uberon + mouth pit + oral ectoderm + oral pit + UBERON:0000930 + + + + + stomodeum + http://upload.wikimedia.org/wikipedia/commons/9/93/Gray977.png + + + + + Anterior part of the embryonic digestive tract that develops into a mouth. The stomodeum includes as parts an invagination of the ectoderm and the stomodeal cavity. + + + + + + + + Anterior part of the embryonic alimentary canal formed as an invagination of the ectoderm; the future mouth.[TAO] + 2012-08-14 + TAO:0001290 + TAO + ZFIN:curator + + + + + the primordial mouth region of the developing head, initially a midline ectodermal depression between the forebrain bulge (cranially) and the heart bulge (caudally) and between the maxillary and mandibular components of the first pharyngeal arch; the stomodeum is separated from the anterior end of the foregut by the buccopharyngeal membrane; the mouth is developed partly from the stomodeum, and partly from the floor of the anterior portion of the foregut; the lips, teeth, and gums are formed from the walls of the stomodeum, but the tongue is developed in the floor of the pharynx + MP:0012522 + NCBITaxon:40674 + + + + + stomodeal-hypophyseal primordium + XAO:0000269 + + + + + UMLS:C1514977 + ncithesaurus:Stomodeum + + + + + mouth primordium + XAO:0000269 + + + + + primitive oral cavity + + + + + + stomatodeum + + + + + + mouth pit + EMAPA:16263 + + + + + oral ectoderm + ZFA:0001290 + ZFIN:ZDB-PUB-100726-23 + + + + + oral pit + EMAPA:16263 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A myogenic muscular circulatory organ found in the vertebrate cardiovascular system composed of chambers of cardiac muscle. It is the primary circulatory organ. + Blood pumping organ composed of four chambers: sinus venosus, atrium, cardiac ventricle and bulbus arteriosus.[TAO] + Part of the circulatory system responsible for pumping blood; composed of three chambers--two atria and one ventricle.[AAO] + relationship type change: differentiates_from lateral plate mesoderm (AAO:0010574) CHANGED TO: develops_from lateral plate mesoderm (UBERON:0003081)[AAO] + As noted, the hearts of birds and mammals have four chambers that arises from the two chambers (atrium and ventricle) of the fish heart.[well established][VHOG] + cardiac + + + + AAO:0010210 + BILA:0000020 + BTO:0000562 + CALOHA:TS-0445 + EFO:0000815 + EHDAA2:0000738 + EHDAA:420 + EMAPA:16105 + EV:0100018 + FMA:7088 + GAID:174 + MA:0000072 + MAT:0000036 + MESH:D006321 + MIAA:0000036 + NCIT:C12727 + OpenCyc:Mx4rvVjvDpwpEbGdrcN5Y29ycA + TAO:0000114 + UMLS:C0018787 + VHOG:0000276 + XAO:0000064 + ZFA:0000114 + galen:Heart + chambered heart + vertebrate heart + branchial heart + uberon + Herz@de + cardium + UBERON:0000948 + + + + + + + Taxon notes:" the ascidian tube-like heart lacks chambers....The ascidian heart is formed after metamorphosis as a simple tube-like structure with a single-layered myoepithelium that is continuous with a single-layered pericar- dial wall. It lacks chambers and endocardium.... The innovation of the chambered heart was a key event in vertebrate evolution, because the chambered heart generates one-way blood flow with high pressure, a critical requirement for the efficient blood supply of large-body vertebrates... all extant vertebrates have hearts with two or more chambers (Moorman and Christoffels 2003)" DOI:10.1101/gad.1485706 + heart + + + + + + + + + + + MA + + + + + A myogenic muscular circulatory organ found in the vertebrate cardiovascular system composed of chambers of cardiac muscle. It is the primary circulatory organ. + + + + + + + Blood pumping organ composed of four chambers: sinus venosus, atrium, cardiac ventricle and bulbus arteriosus.[TAO] + 2012-08-14 + TAO:0000114 + TAO + ZFIN:curator + + + + + Part of the circulatory system responsible for pumping blood; composed of three chambers--two atria and one ventricle.[AAO] + 2012-06-20 + AAO:0010210 + AAO + AAO:BJB + + + + + relationship type change: differentiates_from lateral plate mesoderm (AAO:0010574) CHANGED TO: develops_from lateral plate mesoderm (UBERON:0003081)[AAO] + 2012-06-20 + AAO:0010210 + AAO + + + + + As noted, the hearts of birds and mammals have four chambers that arises from the two chambers (atrium and ventricle) of the fish heart.[well established][VHOG] + 2012-09-17 + VHOG:0000276 + VHOG + + ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.481 + + + + + UMLS:C0018787 + ncithesaurus:Heart + + + + + chambered heart + + + + + + branchial heart + + + + + + Herz@de + BTO:0000562 + + + + + cardium + EMAPA:16105 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP]. + requires review for applicability to invertebrate structures, e.g. synganglion + Cavitated compound organ which is comprised of gray and white matter and surrounds the cerebral ventricular system.[TAO] + Part of the central nervous system situated within the cranium and composed of both nerve cell bodies and nerve fibers.[AAO] + The part of the central nervous system contained within the cranium, comprising the forebrain, midbrain, hindbrain, and metencephalon. It is derived from the anterior part of the embryonic neural tube (or the encephalon). Does not include retina. (CUMBO) + (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...) (reference 1); The neural tube is destined to differentiate into the brain and spinal cord (the central nervous system) (reference 2).[well established][VHOG] + + + + + + + AAO:0010478 + ABA:Brain + BAMS:Br + BAMS:Brain + BILA:0000135 + BIRNLEX:796 + BTO:0000142 + CALOHA:TS-0095 + DHBA:10155 + EFO:0000302 + EHDAA2:0000183 + EHDAA:2641 + EHDAA:6485 + EMAPA:16894 + EV:0100164 + FBbt:00005095 + FMA:50801 + GAID:571 + HBA:4005 + MA:0000168 + MAT:0000098 + MBA:8 + MBA:997 + MESH:D001921 + MIAA:0000098 + NCIT:C12439 + OpenCyc:Mx4rvVjT65wpEbGdrcN5Y29ycA + PBA:3999 + TAO:0000008 + UMLS:C0006104 + UMLS:C1269537 + VHOG:0000157 + XAO:0000010 + ZFA:0000008 + galen:Brain + http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=21 + uberon + encephalon + suprasegmental levels of nervous system + suprasegmental structures + synganglion + the brain + UBERON:0000955 + + + + + + + brain + + + + + + GO + + + + + + + + + + + FMA + + + + + + + + + + + Bgee:AN + + + + + The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP]. + + + + + + + Cavitated compound organ which is comprised of gray and white matter and surrounds the cerebral ventricular system.[TAO] + 2012-08-14 + TAO:0000008 + TAO + ZFIN:curator + + + + + Part of the central nervous system situated within the cranium and composed of both nerve cell bodies and nerve fibers.[AAO] + 2012-06-20 + AAO:0010478 + AAO + AAO:BJB + + + + + The part of the central nervous system contained within the cranium, comprising the forebrain, midbrain, hindbrain, and metencephalon. It is derived from the anterior part of the embryonic neural tube (or the encephalon). Does not include retina. (CUMBO) + + + + + + (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...) (reference 1); The neural tube is destined to differentiate into the brain and spinal cord (the central nervous system) (reference 2).[well established][VHOG] + 2012-09-17 + VHOG:0000157 + VHOG + + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.165 + + + + + UMLS:C0006104 + BIRNLEX:796 + + + + + UMLS:C0006104 + ncithesaurus:Brain + + + + + UMLS:C1269537 + BIRNLEX:796 + + + + + http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=21 + BIRNLEX:796 + + + + + encephalon + BTO:0000142 + + + + + suprasegmental levels of nervous system + NeuroNames:21 + + + + + suprasegmental structures + NeuroNames:21 + + + + + the brain + NeuroNames:21 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The thin layer of gray matter on the surface of the cerebral hemisphere that develops from the telencephalon. It consists of the neocortex (6 layered cortex or isocortex), the hippocampal formation and the olfactory cortex. + We follow NIFSTD in defining cerebral cortex and including both neocortex and hippocampal formation (DG+hippocampus). + + The cerebral cortex is a structure within the brain that plays a key role in memory, attention, perceptual awareness, thought, language, and consciousness. It constitutes the outermost layer of the cerebrum. In preserved brains, it has a grey color, hence the name 'grey matter'. Grey matter is formed by neurons and their unmyelinated fibers, whereas the white matter below the grey matter of the cortex is formed predominantly by myelinated axons interconnecting different regions of the central nervous system. The human cerebral cortex is 2-4 mm (0.08-0.16 inches) thick. The surface of the cerebral cortex is folded in large mammals, such that more than two-thirds of the cortical surface is buried in the grooves, called 'sulci. ' The phylogenetically most recent part of the cerebral cortex, the neocortex, also called isocortex, is differentiated into six horizontal layers; the more ancient part of the cerebral cortex, the hippocampus (also called archicortex), has at most three cellular layers, and is divided into subfields. Relative variations in thickness or cell type (among other parameters) allow us to distinguish between different neocortical architectonic fields. The geometry of at least some of these fields seems to be related to the anatomy of the cortical folds, and, for example, layers in the upper part of the cortical ridges seem to be more clearly differentiated than in its deeper parts. [WP,unvetted][Wikipedia:Cerebral_cortex]. + Migration of neurons from the basal or striatal portions of the anterior part of the neural tube occurs to varying degrees in different vertebrate classes, but a true cerebral cortex is generally acknowledged to have made its first appearance in reptiles. The definition can be unambiguous, since 'cortex' simply implies the existence of a surface neuronal layer with an overlying 'zonal lamina' or 'molecular' layer containing dendrites and axons, which is separated from the underlying basal 'matrix' by white matter. Although reptilian cerebral cortex does indeed fulfill these conditions in certain locations, the separation from striatal structures is often indistinct, so that it may even be argued that some primitive dipnoans possess a pallium or cortex. Nevertheless, an extensive laminated layer separated by underlying white matter is well represented only in reptiles and mammals.[well established][VHOG] + hagfishes have independently evolved a highly laminated cerebral cortex, comparable in many ways to the cerebral cortex of mammals [http://icb.oxfordjournals.org/content/42/4/743] + + + + + BAMS:C + BAMS:CTX + BAMS:Cerebral_cortex + BAMS:Cx + BIRNLEX:1494 + BM:Tel-Cx + BTO:0000233 + CALOHA:TS-0091 + DHBA:10159 + EFO:0000328 + EHDAA2:0000234 + EHDAA:5464 + EMAPA:17544 + EV:0100166 + FMA:61830 + GAID:629 + HBA:4008 + MA:0000185 + MAT:0000108 + MBA:688 + MESH:A08.186.211.730.885.213 + MIAA:0000108 + NCIT:C12443 + PBA:128011354 + UMLS:C0007776 + VHOG:0000722 + http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=39 + cortex of cerebral hemisphere + uberon + brain cortex + cortex cerebralis + cortex cerebri + cortical plate (CTXpl) + cortical plate (areas) + pallium of the brain + UBERON:0000956 + + + + cerebral cortex + http://upload.wikimedia.org/wikipedia/commons/7/7b/Cerebral_Cortex_location.jpg + http://upload.wikimedia.org/wikipedia/commons/9/9a/Brainmaps-macaque-hippocampus.jpg + + + + + + FMA + + + + + + + + + + + GO + ISBN:0471888893 + + + + + + + + + + + FMA + MA + + + + + The thin layer of gray matter on the surface of the cerebral hemisphere that develops from the telencephalon. It consists of the neocortex (6 layered cortex or isocortex), the hippocampal formation and the olfactory cortex. + BIRNLEX:1494 + + + + + The cerebral cortex is a structure within the brain that plays a key role in memory, attention, perceptual awareness, thought, language, and consciousness. It constitutes the outermost layer of the cerebrum. In preserved brains, it has a grey color, hence the name 'grey matter'. Grey matter is formed by neurons and their unmyelinated fibers, whereas the white matter below the grey matter of the cortex is formed predominantly by myelinated axons interconnecting different regions of the central nervous system. The human cerebral cortex is 2-4 mm (0.08-0.16 inches) thick. The surface of the cerebral cortex is folded in large mammals, such that more than two-thirds of the cortical surface is buried in the grooves, called 'sulci. ' The phylogenetically most recent part of the cerebral cortex, the neocortex, also called isocortex, is differentiated into six horizontal layers; the more ancient part of the cerebral cortex, the hippocampus (also called archicortex), has at most three cellular layers, and is divided into subfields. Relative variations in thickness or cell type (among other parameters) allow us to distinguish between different neocortical architectonic fields. The geometry of at least some of these fields seems to be related to the anatomy of the cortical folds, and, for example, layers in the upper part of the cortical ridges seem to be more clearly differentiated than in its deeper parts. [WP,unvetted][Wikipedia:Cerebral_cortex]. + + + + + + Migration of neurons from the basal or striatal portions of the anterior part of the neural tube occurs to varying degrees in different vertebrate classes, but a true cerebral cortex is generally acknowledged to have made its first appearance in reptiles. The definition can be unambiguous, since 'cortex' simply implies the existence of a surface neuronal layer with an overlying 'zonal lamina' or 'molecular' layer containing dendrites and axons, which is separated from the underlying basal 'matrix' by white matter. Although reptilian cerebral cortex does indeed fulfill these conditions in certain locations, the separation from striatal structures is often indistinct, so that it may even be argued that some primitive dipnoans possess a pallium or cortex. Nevertheless, an extensive laminated layer separated by underlying white matter is well represented only in reptiles and mammals.[well established][VHOG] + 2012-09-17 + VHOG:0000722 + VHOG + + DOI:10.1111/j.1749-6632.1969.tb20437.x Kruger L, Experimental analyses of the reptilian nervous system. Annals of the New York Academy of Sciences (1969) + + + + + UMLS:C0007776 + BIRNLEX:1494 + + + + + UMLS:C0007776 + ncithesaurus:Cortex + + + + + http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=39 + BIRNLEX:1494 + + + + + cortex of cerebral hemisphere + BTO:0000233 + FMA:61830 + + + + + brain cortex + BTO:0000233 + + + + + cortex cerebralis + NeuroNames:39 + + + + + + cortex cerebri + + + + + + + cortical plate (CTXpl) + NeuroNames:39 + + + + + cortical plate (areas) + NeuroNames:39 + + + + + pallium of the brain + BTO:0000233 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure + corneal + Compared to terrestial animals, the cornea of zebrafish is relatively flat. It consists of nonpigmented, stratified squamous nonkeratinizing epithelial cells, attached to a thick basement membrane that is considered to be analogous to the Bowman's membrane in mammals. In fish, and aquatic vertebrates in general, the cornea plays no role in focusing light, since it has virtually the same refractive index as water + + + + AAO:0010344 + BTO:0000286 + CALOHA:TS-0171 + EFO:0000377 + EHDAA2:0000316 + EHDAA:10199 + EMAPA:17161 + EV:0100341 + FMA:58238 + GAID:892 + MA:0000266 + MESH:D003315 + NCIT:C12342 + OpenCyc:Mx4rvViBa5wpEbGdrcN5Y29ycA + TAO:0000640 + UMLS:C0010031 + VHOG:0000164 + XAO:0000180 + ZFA:0000640 + cornea of camera-type eye + uberon + corneas + tunica cornea + UBERON:0000964 + + + + + cornea + http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg + + + + + + XAO + + + + + + + + + + + MA + + + + + + + + + + + MA + + + + + + + + + + + FMA-isa + + + + + + + + + + + definitional + + + + + the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure + ISBN:0-683-40008-8 + MESH:A09.371.060.217 + MP:0001312 + + + + + UMLS:C0010031 + ncithesaurus:Cornea + + + + + cornea of camera-type eye + GO:0061303 + + + + + corneas + ZFA:0000640 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Transparent part of camera-type eye that helps to refract light to be focused on the retina. + The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG] + This class excludes compound eye corneal lenses. + + + + AAO:0010348 + BTO:0000723 + CALOHA:TS-0545 + EHDAA:9057 + EMAPA:17838 + EV:0100343 + FMA:58241 + MA:0000275 + MAT:0000141 + MESH:A09.371.509 + MIAA:0000141 + NCIT:C12743 + OpenCyc:Mx4rvVj0fZwpEbGdrcN5Y29ycA + RETIRED_EHDAA2:0000975 + TAO:0000035 + UMLS:C0023317 + VHOG:0000169 + XAO:0000008 + ZFA:0000035 + camera-type eye lens + eye lens + lens + lens crystallina + uberon + crystalline lens + lenses + ocular lens + UBERON:0000965 + + + + The lens is avascular and nourished by diffusion from the aqueous and vitreous + lens of camera-type eye + + + + + Transparent part of camera-type eye that helps to refract light to be focused on the retina. + + + + + + + The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG] + 2012-09-17 + VHOG:0000169 + VHOG + + DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007) + + + + + UMLS:C0023317 + ncithesaurus:Crystalline_Lens + + + + + camera-type eye lens + GO:0002088 + + + + + eye lens + + + + + + lens + + + + + + lens crystallina + + + + + + crystalline lens + BTO:0000723 + + + + + lenses + ZFA:0000035 + + + + + + ocular lens + BTO:0000723 + + + + + + + + + + + + + + + + + + + + + + + + + + + + The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. + The portion of the eye developing from the optic primordium and including the neural retina and the retinal pigment layer. Kimmel et al, 1995.[TAO] + The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG] + retinal + + + + + + AAO:0010352 + BAMS:R + BIRNLEX:1153 + BTO:0001175 + CALOHA:TS-0865 + EFO:0000832 + EHDAA2:0001627 + EHDAA:4757 + EMAPA:17168 + EV:0100348 + FMA:58301 + GAID:755 + MA:0000276 + MAT:0000142 + MBA:304325711 + MESH:D012160 + MIAA:0000142 + NCIT:C12343 + NIFSTD_RETIRED:birnlex_1156 + OpenCyc:Mx4rvViTfpwpEbGdrcN5Y29ycA + TAO:0000152 + UMLS:C0035298 + UMLS:C1278894 + VHOG:0000229 + XAO:0000009 + ZFA:0000152 + inner layer of eyeball + retina of camera-type eye + tunica interna of eyeball + uberon + Netzhaut + retinas + UBERON:0000966 + + + + + Currently this class encompasses only verteberate AOs but could in theory also include cephalopod - we may want to make a more specific class for vertebrate retina. note that this class excludes ommatidial retinas, as the retina must be part of an eyeball. Use the parent class photoreceptor array / light-sensitive tissue for arthropods + retina + http://upload.wikimedia.org/wikipedia/commons/e/ed/Human_eye_cross-sectional_view_grayscale.png + + + + + + + + + + + EHDAA2 + + + + + The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. + + ZFIN:curator + + + + + The portion of the eye developing from the optic primordium and including the neural retina and the retinal pigment layer. Kimmel et al, 1995.[TAO] + 2012-08-14 + TAO:0000152 + TAO + ZFIN:curator + + + + + The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG] + 2012-09-17 + VHOG:0000229 + VHOG + + DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007) + + + + + UMLS:C0035298 + BIRNLEX:1153 + + + + + UMLS:C0035298 + ncithesaurus:Retina + + + + + UMLS:C1278894 + BIRNLEX:1153 + + + + + retina of camera-type eye + GO:0060041 + + + + + Netzhaut + BTO:0001175 + + + + + retinas + ZFA:0000152 + + + + + + + + + + + + + + + + An organ that detects light. + This class encompasses a variety of light-detecting structures from different phyla with no implication of homology, from the compound insect eye to the vertebrate camera-type eye (distinct classes are provided for each) + ocular + optic + Note that whilst this is classified as an organ, it is in fact more of a unit composed of different structures: in Drosophila, it includes the interommatidial bristle as a part; we consider here the vertebrate eye to include the eyeball/eye proper as a part, with the eye having as parts (when present): eyelids, conjuctiva, + + BILA:0000017 + BTO:0000439 + CALOHA:TS-0309 + EFO:0000827 + EV:0100336 + FBbt:00005162 + GAID:69 + MAT:0000140 + MESH:D005123 + MIAA:0000140 + OpenCyc:Mx4rvViTvpwpEbGdrcN5Y29ycA + uberon + light-detecting organ + visual apparatus + UBERON:0000970 + + + + + + eye + + + + + An organ that detects light. + + + + + + visual apparatus + EV:0100336 + + + + + + + + + + + + + + + + + + + + + + + + + + + An organism subdivision that extends from the head to the pectoral girdle, encompassing the cervical vertebral column. + true necks are considered to be present when the pectoral girdle is separate from the skull - Tiktaalik is the earliest known fish to have a true neck. + + cervical + + + + AEO:0000108 + BTO:0000420 + CALOHA:TS-2045 + EFO:0000967 + EHDAA2:0003108 + EMAPA:35587 + FMA:7155 + GAID:86 + MA:0000024 + MAT:0000297 + MESH:D009333 + MIAA:0000297 + NCIT:C13063 + OpenCyc:Mx4rvVjLF5wpEbGdrcN5Y29ycA + UMLS:C0027530 + galen:Neck + uberon + collum + neck (volume) + UBERON:0000974 + + + + neck + Female:neck.jpg + + + + + An organism subdivision that extends from the head to the pectoral girdle, encompassing the cervical vertebral column. + + + + + + + ISBN:9780674021839 + + + + + UMLS:C0027530 + ncithesaurus:Neck + + + + + collum + + + + + + + neck (volume) + FMA:7155 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Anatomical cluster that consists of two or more adjacent skeletal structures, which may be interconnected by various types of tissue[VSAO]. + Anatomical cluster that consists of two or more adjacent bones or cartilages, which may be interconnected by various types of tissue.[VSAO] + Anatomical cluster which consists of two or more adjacent bones or cartilages, which may be interconnected by various types of tissue.[TAO] + articulation + joint + + + + AEO:0000182 + BTO:0001686 + CALOHA:TS-2023 + EFO:0000948 + EMAPA:35456 + FMA:7490 + GAID:102 + MA:0000319 + MAT:0000188 + MESH:D007596 + MIAA:0000188 + NCIT:C13044 + OpenCyc:Mx4rvVjjdpwpEbGdrcN5Y29ycA + RETIRED_EHDAA2:0003182 + TAO:0000367 + UMLS:C0022417 + VHOG:0001276 + VSAO:0000101 + XAO:0000171 + ZFA:0001596 + galen:Joint + uberon + articular joint + joints + UBERON:0000982 + + + + + + skeletal joint + + + + + Anatomical cluster that consists of two or more adjacent skeletal structures, which may be interconnected by various types of tissue[VSAO]. + + + GO_REF:0000034 + VSAO:0000101 + + + + + Anatomical cluster that consists of two or more adjacent bones or cartilages, which may be interconnected by various types of tissue.[VSAO] + 2012-08-14 + VSAO:0000101 + VSAO + PSPUB:0000170 + + + + + Anatomical cluster which consists of two or more adjacent bones or cartilages, which may be interconnected by various types of tissue.[TAO] + 2012-08-14 + TAO:0000367 + TAO + TAO:pem + + + + + articulation + VSAO:0000101 + + + + + joint + FMA:7490 + VSAO:0000101 + + + + + UMLS:C0022417 + ncithesaurus:Joint + + + + + articular joint + BTO:0001686 + + + + + joints + ZFA:0001596 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The outer epithelial layer of the skin that is superficial to the dermis. + A cellular, multilayered epithelium derived from the ectoderm. Zebrafish epidermis consists only of living cells unlike terrestrial vertebrates in which dead, keratinized cells are present. Le Guellec et al, 2004.[TAO] + The outer epithelial layer of the external integument of the body that is derived from the embryonic epiblast.[AAO] + relationship loss: subclass external integument structures (AAO:0000961)[AAO] + (...) outer epithelia in all metazoan animals are homologous. (...) The ancestor of all metazoans likely had an epidermis with a basal extracellular matrix (ECM), an apical extracellular glycocalyx, and one cilium with a striated rootlet per cell.[well established][VHOG] + epidermal + Zebrafish epidermis consists only of living cells unlike terrestrial vertebrates in which dead, keratinized cells are present. In terrestrial vertebrates the epidermis often forms an outer keratinized or cornified layer, the stratum corneum. Interaction between the epideris and dermis gives rise to feathers (birds), hair and mammary glands (mammals), teeth and scales (placoid: chondrichthyans; cosmoids, ganoid, cycloid in bony fishes). + epidermis + skin + + + + AAO:0000143 + BTO:0000404 + CALOHA:TS-0283 + EFO:0000954 + EMAPA:17528 + EV:0100153 + FMA:70596 + GAID:932 + MA:0000153 + MAT:0000154 + MESH:D004817 + MIAA:0000154 + NCIT:C12708 + TAO:0000105 + UMLS:C0014520 + VHOG:0000077 + XAO:0000028 + ZFA:0000105 + vertebrate epidermis + uberon + UBERON:0001003 + + + + + skin epidermis + + + + + The outer epithelial layer of the skin that is superficial to the dermis. + + ISBN:0073040584 + + + + + A cellular, multilayered epithelium derived from the ectoderm. Zebrafish epidermis consists only of living cells unlike terrestrial vertebrates in which dead, keratinized cells are present. Le Guellec et al, 2004.[TAO] + 2012-08-14 + TAO:0000105 + TAO + ZFIN:curator + + + + + The outer epithelial layer of the external integument of the body that is derived from the embryonic epiblast.[AAO] + 2012-06-20 + AAO:0000143 + AAO + AAO:BJB + + + + + relationship loss: subclass external integument structures (AAO:0000961)[AAO] + 2012-06-20 + AAO:0000143 + AAO + + + + + (...) outer epithelia in all metazoan animals are homologous. (...) The ancestor of all metazoans likely had an epidermis with a basal extracellular matrix (ECM), an apical extracellular glycocalyx, and one cilium with a striated rootlet per cell.[well established][VHOG] + 2012-09-17 + VHOG:0000077 + VHOG + + ISBN:978-0198566694 Schmidt-Rhaesa A, The evolution of organ systems (2007) p.71-72 + + + + + UMLS:C0014520 + ncithesaurus:Epidermis + + + + + + + + + + + + + + + + + + + + + + + + Functional system which consists of structures involved in respiration. + The anatomical system in which the exchange of oxygen and carbon dioxide between the organism and its environment.[AAO] + There is no doubt that the primitive pattern of vertebrate air-breathing is the buccal pulse pump found in actinopterygian fishes.[well established][VHOG] + + + + AAO:0000541 + BTO:0000203 + CALOHA:TS-1319 + EFO:0000804 + EHDAA2:0001604 + EHDAA:2203 + EMAPA:16727 + EV:0100036 + FMA:7158 + GAID:78 + MA:0000327 + MAT:0000030 + MESH:D012137 + MIAA:0000030 + NCIT:C12779 + OpenCyc:Mx4rvVjzFJwpEbGdrcN5Y29ycA + TAO:0000272 + UMLS:C0035237 + VHOG:0000202 + XAO:0000117 + ZFA:0000272 + apparatus respiratorius + respiratory system + uberon + Atmungssystem + apparatus respiratorius + systema respiratorium + UBERON:0001004 + + + + + + respiratory system + http://upload.wikimedia.org/wikipedia/commons/5/5e/Respiratory_system_complete_en.svg + + + + + Functional system which consists of structures involved in respiration. + + + + + + + The anatomical system in which the exchange of oxygen and carbon dioxide between the organism and its environment.[AAO] + 2012-06-20 + AAO:0000541 + AAO + AAO:BJB + + + + + There is no doubt that the primitive pattern of vertebrate air-breathing is the buccal pulse pump found in actinopterygian fishes.[well established][VHOG] + 2012-09-17 + VHOG:0000202 + VHOG + + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.599 and Figure 18-23 + + + + + UMLS:C0035237 + ncithesaurus:Respiratory_System + + + + + Atmungssystem + BTO:0000203 + + + + + apparatus respiratorius + BTO:0000203 + + + + + systema respiratorium + + + + + + + + + + + + + + + + + + + + + + + + + Anatomical system that has as its parts the organs devoted to the ingestion, digestion, and assimilation of food and the discharge of residual wastes. + An anatomical system consisting of the alimentary canal and digestive glands responsible for intake, absorption, digestion and excretion of food.[AAO] + digestive + many anatomy ontologies consider gastrointestinal system synonymous with digestive system. here we follow MA in dividing digestive system into gastrointestinal and hepatobiliary. hepatobiliary includes the liver and biliary tract. species-specific AO classes are categorized according to whether liver is included. For example, XAO includes liver as part of XAO:0000125 alimentary system, so we assume this class is the more generic class + + + AAO:0000129 + BILA:0000082 + BTO:0000058 + CALOHA:TS-1293 + EFO:0000793 + EV:0100056 + FBbt:00005055 + FMA:7152 + GAID:278 + MA:0002431 + MAT:0000018 + MESH:D004064 + MIAA:0000018 + TADS:0000170 + TAO:0000339 + WBbt:0005748 + XAO:0000125 + ZFA:0000339 + galen:DigestiveSystem + ncithesaurus:Digestive_System + uberon + alimentary system + alimentary tract + gastrointestinal system + gut + UBERON:0001007 + + + + + digestive system + + + + + Anatomical system that has as its parts the organs devoted to the ingestion, digestion, and assimilation of food and the discharge of residual wastes. + + FB:gg + NLM:alimentary+system + + + + + An anatomical system consisting of the alimentary canal and digestive glands responsible for intake, absorption, digestion and excretion of food.[AAO] + 2012-06-20 + AAO:0000129 + AAO + AAO:BJB + + + + + many anatomy ontologies consider gastrointestinal system synonymous with digestive system. here we follow MA in dividing digestive system into gastrointestinal and hepatobiliary. hepatobiliary includes the liver and biliary tract. species-specific AO classes are categorized according to whether liver is included. For example, XAO includes liver as part of XAO:0000125 alimentary system, so we assume this class is the more generic class + MA + + + + + + + + + + + + + + + + + + + + + + organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis[WP]. + the cardiovascular system and the lymphatic system are parts of the circulatory system + + Anatomical system of ion binding, a pumping mechanism, and an efficient vascular system; consisting of the blood, heart, and blood and lymph vessels, respectively.[AAO] + We should divest ourselves of the view that earlier vertebrate groups were 'on their way' to becoming mammals, as clearly they were not such visionaries. Neither were their systems 'imperfect' as earlier anatomists thought. Instead, their circulatory systems served them well to address the ecological demands arising from their lifestyles.[well established][VHOG] + + AAO:0000959 + CALOHA:TS-2103 + FBbt:00005057 + OpenCyc:Mx4rvVjzG5wpEbGdrcN5Y29ycA + VHOG:0001248 + uberon + systema cardiovasculare + UBERON:0001009 + + circulatory system + http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg + + + + + organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis[WP]. + + + + + + + WBbt coelomocyte currently classified as circulating cell + + + + + Anatomical system of ion binding, a pumping mechanism, and an efficient vascular system; consisting of the blood, heart, and blood and lymph vessels, respectively.[AAO] + 2012-06-20 + AAO:0000959 + AAO + AAO:BJB + + + + + We should divest ourselves of the view that earlier vertebrate groups were 'on their way' to becoming mammals, as clearly they were not such visionaries. Neither were their systems 'imperfect' as earlier anatomists thought. Instead, their circulatory systems served them well to address the ecological demands arising from their lifestyles.[well established][VHOG] + 2012-09-17 + VHOG:0001248 + VHOG + + ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.493 + + + + + systema cardiovasculare + + + + + + + + + + + + Portion of connective tissue composed of adipocytes enmeshed in areolar tissue + Connective tissue in which fat is stored.[TAO] + Tissue that contains adipocytes, used for cushioning, thermal insulation, lubrication (primarily in the pericardium) and energy storage.[AAO] + relationship loss: subclass connective tissue proper (AAO:0000099)[AAO] + Adipose tissue is unique to vertebrates. It is found in mostmammals, birds, reptiles and amphibians, and a variety is found in some species of fish. Furthermore, in insects the fat body found in larvae as well as in adults shares some homology with adipose tissue.[well established][VHOG] + adipose + In humans, adipose tissue is located beneath the skin (subcutaneous fat), around internal organs (visceral fat), in bone marrow (yellow bone marrow) and in breast tissue. Adipose tissue is found in specific locations, which are referred to as adipose depots. Adipose tissue contains several cell types, with the highest percentage of cells being adipocytes, which contain fat droplets. Other cell types include fibroblasts, macrophages, and endothelial cells. Adipose tissue contains many small blood vessels.; Mice have eight major adipose depots, four of which are within the abdominal cavity. The paired gonadal depots are attached to the uterus and ovaries in females and the epididymis and testes in males; the paired retroperitoneal depots are found along the dorsal wall of the abdomen, surrounding the kidney, and, when massive, extend into the pelvis. The mesenteric depot forms a glue-like web that supports the intestines, and the omental depot, which originates near the stomach and spleen, and, when massive, extends into the ventral abdomen. + in FMA this is dense irregular connective tissue + + + + AAO:0000001 + AEO:000020 + BTO:0001487 + CALOHA:TS-0013 + EFO:0000790 + EHDAA2:0003120 + EMAPA:35112 + EV:0100381 + FMA:20110 + GAID:920 + MA:0000009 + MAT:0000015 + MESH:D000273 + MIAA:0000015 + NCIT:C12472 + OpenCyc:Mx4rvVjc_ZwpEbGdrcN5Y29ycA + TAO:0002134 + UMLS:C0001527 + VHOG:0001284 + XAO:0003049 + ZFA:0005345 + galen:FattyTissue + fat + fat tissue + fatty tissue + uberon + adipose + bodyfat + fatty depot + UBERON:0001013 + + + + + adipose tissue + + + + + + FMA + + + + + Portion of connective tissue composed of adipocytes enmeshed in areolar tissue + + + MESH:A10.165.114 + MGI:cwg + MP:0000003 + + + + + Connective tissue in which fat is stored.[TAO] + 2012-08-14 + TAO:0002134 + TAO + ZFIN:curator + + + + + Tissue that contains adipocytes, used for cushioning, thermal insulation, lubrication (primarily in the pericardium) and energy storage.[AAO] + 2012-06-20 + AAO:0000001 + AAO + AAO:LAP + + + + + relationship loss: subclass connective tissue proper (AAO:0000099)[AAO] + 2012-06-20 + AAO:0000001 + AAO + + + + + Adipose tissue is unique to vertebrates. It is found in mostmammals, birds, reptiles and amphibians, and a variety is found in some species of fish. Furthermore, in insects the fat body found in larvae as well as in adults shares some homology with adipose tissue.[well established][VHOG] + 2012-09-17 + VHOG:0001284 + VHOG + + DOI:10.1017/S0029665107005423 Haugen F, Drevon CA, The interplay between nutrients and the adipose tissue. The Proceedings of the Nutrition Society (2007) + + + + + in FMA this is dense irregular connective tissue + FMA + + + + + UMLS:C0001527 + ncithesaurus:Adipose_Tissue + + + + + fat + MA:0000009 + + + + + adipose + BTO:0001487 + + + + + bodyfat + BTO:0001487 + + + + + + + + + + + + + + + + + + + + + + A subdivision of the muscular system corresponding to a subdisivision of an organism. + In FMA this is classified as a set of organs. ZFA musculature system has subtypes, so it is classified here. WBbt muscular system has subtypes so it goes here. Note that we use the MA term set of skeletal muscles here as it seems most appropriate (*not* MA:musculature). AAO is generally confused here. + + + AAO:0011066 + BTO:0000887 + EFO:0001949 + EMAPA:32715 + EMAPA:35577 + FMA:32558 + MA:0000165 + NCIT:C13056 + OpenCyc:Mx4rvVjmr5wpEbGdrcN5Y29ycA + TAO:0000548 + UMLS:C0026845 + VSAO:0005038 + WBbt:0005737 + ZFA:0000548 + muscle group + muscles set + musculature + musculi + set of muscles + set of skeletal muscles + uberon + muscle system + muscles + musculature system + UBERON:0001015 + + + + + musculature + http://upload.wikimedia.org/wikipedia/commons/e/e5/Muscles_anterior_labeled.png + + + + + A subdivision of the muscular system corresponding to a subdisivision of an organism. + + + + + + + In FMA this is classified as a set of organs. ZFA musculature system has subtypes, so it is classified here. WBbt muscular system has subtypes so it goes here. Note that we use the MA term set of skeletal muscles here as it seems most appropriate (*not* MA:musculature). AAO is generally confused here. + FMA + + + + + UMLS:C0026845 + ncithesaurus:Muscle + + + + + musculi + FMA:32558 + FMA:TA + + + + + + set of muscles + FMA:32558 + + + + + set of skeletal muscles + MA:0000165 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior [CUMBO]. + A regulatory system of the body that consists of neurons and neuroglial cells. The nervous system is divided into two parts, the central nervous system (CNS) and the peripheral nervous system (PNS). (Source: BioGlossary, www.Biology-Text.com)[TAO] + Anatomical system consisting of nerve bodies and nerve fibers which regulate the response of the body to external and internal stimuli.[AAO] + Nervous systems evolved in the ancestor of Eumetazoa.[well established][VHOG] + nervous + neural + + + + + AAO:0000324 + BILA:0000079 + BIRNLEX:844 + BTO:0001484 + CALOHA:TS-1313 + EFO:0000802 + EHDAA2:0001246 + EHDAA:826 + EMAPA:16469 + EV:0100162 + FBbt:00005093 + FMA:7157 + GAID:466 + MA:0000016 + MAT:0000026 + MESH:D009420 + MIAA:0000026 + NCIT:C12755 + OpenCyc:Mx4rvViT_pwpEbGdrcN5Y29ycA + TAO:0000396 + UMLS:C0027763 + VHOG:0000402 + WBbt:0005735 + XAO:0000177 + ZFA:0000396 + neurological system + nerve net + uberon + systema nervosum + UBERON:0001016 + + + + + + nervous system + http://upload.wikimedia.org/wikipedia/commons/b/b2/TE-Nervous_system_diagram.svg + http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png + + + + + + + + + + + Bgee:AN + + + + + The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior [CUMBO]. + + BIRNLEX:844 + ISBN:0-14-051288-8 + ISBN:3110148986 + NLM:nervous+system + WB:rynl + ZFIN:curator + + + + + A regulatory system of the body that consists of neurons and neuroglial cells. The nervous system is divided into two parts, the central nervous system (CNS) and the peripheral nervous system (PNS). (Source: BioGlossary, www.Biology-Text.com)[TAO] + 2012-08-14 + TAO:0000396 + TAO + ZFIN:curator + + + + + Anatomical system consisting of nerve bodies and nerve fibers which regulate the response of the body to external and internal stimuli.[AAO] + 2012-06-20 + AAO:0000324 + AAO + AAO:BJB + + + + + Nervous systems evolved in the ancestor of Eumetazoa.[well established][VHOG] + 2012-09-17 + VHOG:0000402 + VHOG + + ISBN:978-0198566694 Schmidt-Rhaesa A, The evolution of organ systems (2007) p.117 + + + + + UMLS:C0027763 + ncithesaurus:Nervous_System + + + + + neurological system + GO:0050877 + + + + + nerve net + + + + + + systema nervosum + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord. + Part of the nervous system which includes the brain and spinal cord.[AAO] + The brain and spinal cord. Kimmel et al, 1995.[TAO] + The central nervous system (CNS) is the part of the nervous system which includes the brain, spinal cord, and nerve cell layer of the retina (CUMBO). + (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...) (reference 1); The neural tube is destined to differentiate into the brain and spinal cord (the central nervous system) (reference 2); Taken together, our data make a very strong case that the complex molecular mediolateral architecture of the developing trunk CNS (central nervous system), as shared between Platynereis and vertebrates, was already present in their last common ancestor, Urbilateria. The concept of bilaterian nervous system centralization implies that neuron types concentrate on one side of the trunk, as is the case in vertebrates and many invertebrates including Platynereis, where they segregate and become spatially organized (as opposed to a diffuse nerve net). Our data reveal that a large part of the spatial organization of the annelid and vertebrate CNS was already present in their last common ancestor, which implies that Urbilateria had already possessed a CNS (reference 3).[well established][VHOG] + + + + + AAO:0000090 + BAMS:CNS + BILA:0000080 + BIRNLEX:1099 + BTO:0000227 + CALOHA:TS-0150 + EFO:0000908 + EHDAA2:0000225 + EHDAA:828 + EMAPA:16470 + EMAPA:16754 + EV:0100163 + FBbt:00005094 + FMA:55675 + GAID:570 + MA:0000167 + MAT:0000457 + MESH:D002490 + NCIT:C12438 + OpenCyc:Mx4rvzYt3pwpEbGdrcN5Y29ycA + TAO:0000012 + UMLS:C0927232 + VHOG:0000293 + XAO:0000215 + ZFA:0000012 + CNS + systema nervosum centrale + cerebrospinal axis + uberon + neuraxis + UBERON:0001017 + + + + + + central nervous system + + + + + + FBbt + cjm + + + + + + + + + + + Bgee:AN + + + + + The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord. + + + GO:0021551 + + + + + Part of the nervous system which includes the brain and spinal cord.[AAO] + 2012-06-20 + AAO:0000090 + AAO + AAO:BJB + + + + + The brain and spinal cord. Kimmel et al, 1995.[TAO] + 2012-08-14 + TAO:0000012 + TAO + ZFIN:curator + + + + + The central nervous system (CNS) is the part of the nervous system which includes the brain, spinal cord, and nerve cell layer of the retina (CUMBO). + BIRNLEX:1099 + + + + + (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...) (reference 1); The neural tube is destined to differentiate into the brain and spinal cord (the central nervous system) (reference 2); Taken together, our data make a very strong case that the complex molecular mediolateral architecture of the developing trunk CNS (central nervous system), as shared between Platynereis and vertebrates, was already present in their last common ancestor, Urbilateria. The concept of bilaterian nervous system centralization implies that neuron types concentrate on one side of the trunk, as is the case in vertebrates and many invertebrates including Platynereis, where they segregate and become spatially organized (as opposed to a diffuse nerve net). Our data reveal that a large part of the spatial organization of the annelid and vertebrate CNS was already present in their last common ancestor, which implies that Urbilateria had already possessed a CNS (reference 3).[well established][VHOG] + 2012-09-17 + VHOG:0000293 + VHOG + + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28 (reference 1), ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.165 (reference 2), DOI:10.1016/j.cell.2007.02.040 Denes AS, Jekely G, Steinmetz PRH, Raible F, Snyman H, Prud'homme B, Ferrier DEK, Balavoine G and Arendt D, Molecular architecture of annelid nerve cord supports common origin of nervous system centralization in Bilateria. Cell (2007) (reference 3) + + + + + UMLS:C0927232 + BIRNLEX:1099 + + + + + UMLS:C0927232 + ncithesaurus:Central_Nervous_System + + + + + CNS + + + + + + systema nervosum centrale + FMA:55675 + FMA:TA + + + + + + cerebrospinal axis + FMA:55675 + + + + + neuraxis + FMA:55675 + + + + + + + + + + + + + + + + + + + + + + + + + + + Anatomical system that overlaps the nervous system and is responsible for receiving and processing sensory information. + An early step in the evolution of neural crest, therefore, may have been the origin of a specific dorsal neural cell population contributing to sensory processing; this would predate the divergence of the amphioxus and vertebrate lineages.[well established][VHOG] + note the distinct between entire sensory system and individual system. this reconciles is_a and part_of distinctions between ssAOs + + AAO:0000555 + BAMS:SEN + BILA:0000099 + EFO:0000805 + EHDAA2:0003094 + EMAPA:16192 + FBbt:00007692 + FMA:75259 + MA:0002442 + MAT:0000031 + MIAA:0000031 + NLXANAT:090816 + TAO:0000282 + VHOG:0001674 + XAO:0003194 + ZFA:0000282 + organa sensuum + sense organ subsystem + sense organs + sense organs set + sensory subsystem + sensory systems + uberon + organa sensuum + sensory organ system + set of sense organs + UBERON:0001032 + + + + sensory system + http://upload.wikimedia.org/wikipedia/commons/c/c0/Gray722.png + + + + + Anatomical system that overlaps the nervous system and is responsible for receiving and processing sensory information. + + + + + + An early step in the evolution of neural crest, therefore, may have been the origin of a specific dorsal neural cell population contributing to sensory processing; this would predate the divergence of the amphioxus and vertebrate lineages.[well established][VHOG] + 2012-09-17 + VHOG:0001674 + VHOG + + DOI:10.1073/pnas.97.9.4449 Shimeld SM and Holland PW. Vertebrate innovations. PNAS (2000) + + + + + organa sensuum + FMA:75259 + FMA:TA + + + + + + sense organs + FMA:75259 + + + + + sense organs set + FMA:75259 + + + + + sensory systems + TAO:0000282 + + + + + + organa sensuum + + + + + + + set of sense organs + FMA:75259 + + + + + + + + + Anterior subdivision of a digestive tract. + Note we define this generically to include invertebrates (partly for consistency with GO), but the class may be split in future. In vertebrates the term may refer to a developmental structure + The anterior portion of the primitive digestive tube of the embryo that lies cephalic to the junction of the yolk stalk, consists of endodermal tissue, and gives rise to the the pharynx, lower respiratory system, esophagus, stomach, duodenum proximal to the biliary tract, liver, pancreas, biliary tract, and gall bladder. + The bilaterian gut is typically a complete tube that opens to the exterior at both ends. It consists of mouth, foregut, midgut, hindgut, and anus (reference 1); Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut (reference 2).[well established][VHOG] + + + + AAO:0011042 + BILA:0000085 + BTO:0000507 + EHDAA2:0000557 + EHDAA:520 + EMAPA:16548 + FBbt:00005379 + FMA:45616 + MA:0001526 + NCIT:C34180 + TGMA:0001014 + UMLS:C0231051 + VHOG:0000285 + XAO:0000232 + uberon + praeenteron + proenteron + UBERON:0001041 + + + + foregut + http://upload.wikimedia.org/wikipedia/commons/9/9a/Gray27.png + + + + + Anterior subdivision of a digestive tract. + + + + + + The anterior portion of the primitive digestive tube of the embryo that lies cephalic to the junction of the yolk stalk, consists of endodermal tissue, and gives rise to the the pharynx, lower respiratory system, esophagus, stomach, duodenum proximal to the biliary tract, liver, pancreas, biliary tract, and gall bladder. + MP:0000474 + + + + + The bilaterian gut is typically a complete tube that opens to the exterior at both ends. It consists of mouth, foregut, midgut, hindgut, and anus (reference 1); Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut (reference 2).[well established][VHOG] + 2012-09-17 + VHOG:0000285 + VHOG + + ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.203, ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11 + + + + + UMLS:C0231051 + ncithesaurus:Foregut + + + + + praeenteron + + + + + + + proenteron + + + + + + + + + + + + + + + + + + + + + + + A portion of the respiratory and digestive tracts; its distal limit is the superior part of the esophagus and it connects the nasal and oral cavities with the esophagus and larynx; it contains the valleculae and the pyriform recesses; its upper limits are the nasal cavity and cranial base.[FEED]. + A funnel-shaped fibromuscular tube that conducts food to the ESOPHAGUS, and air to the LARYNYX and LUNGS. It is located posterior to the NASAL CAVITY; ORAL CAVITY; and LARYNX, and extends from the SKULL BASE to the inferior border of the CRICOID CARTILAGE anteriorly and to the inferior border of the C6 vertebra posteriorly. It is divided into the NASOPHARYNX; OROPHARYNX; and HYPOPHARYNX (laryngopharynx)[MESH:A03.867]. + Anatomical cavity bounded by the derivatives of the branchial arches.[AAO] + Swollen region of the anterior foregut, posterior to the mouth and anterior to the liver; its walls form the jaws and gills. Kimmel et al, 1995.[TAO] + Swollen region of the anterior foregut, posterior to the mouth and anterior to the liver; its walls form the jaws and gills[ZFA:0000056, ZFIN:ZDB-PUB-961014-576]. + The portion of the alimentary canal between the mouth and the oesophagus. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG] + relationship type change: part_of_proxy respiratory system (AAO:0000541) CHANGED TO: develops_from respiratory system (UBERON:0001004)[AAO] + relationship type change: part_of_proxy respiratory system (AAO:0000541) CHANGED TO: part_of respiratory system (UBERON:0001004)[AAO] + (...) the earliest vertebrates possessed unjointed internal and external branchial arches, and musculature encircling the pharynx.[well established][VHOG] + MA/FMA pharynx not part of digestive/alimentary system, we are consistent with this scheme + pharynx + + + + AAO:0000967 + BTO:0001049 + CALOHA:TS-0785 + EFO:0000836 + EHDAA2:0001458 + EHDAA:2947 + EMAPA:16706 + EV:0100065 + FMA:46688 + GAID:155 + MA:0000432 + MESH:A03.867 + NCIT:C12425 + OpenCyc:Mx4rvViv7ZwpEbGdrcN5Y29ycA + TAO:0000056 + UMLS:C0031354 + VHOG:0000462 + XAO:0003227 + ZFA:0000056 + galen:Pharynx + uberon + UBERON:0001042 + + + + + Consider generalizing to deuterostome pharynx + chordate pharynx + + + + + + + + + + + EHDAA2 + + + + + A portion of the respiratory and digestive tracts; its distal limit is the superior part of the esophagus and it connects the nasal and oral cavities with the esophagus and larynx; it contains the valleculae and the pyriform recesses; its upper limits are the nasal cavity and cranial base.[FEED]. + + + + + + A funnel-shaped fibromuscular tube that conducts food to the ESOPHAGUS, and air to the LARYNYX and LUNGS. It is located posterior to the NASAL CAVITY; ORAL CAVITY; and LARYNX, and extends from the SKULL BASE to the inferior border of the CRICOID CARTILAGE anteriorly and to the inferior border of the C6 vertebra posteriorly. It is divided into the NASOPHARYNX; OROPHARYNX; and HYPOPHARYNX (laryngopharynx)[MESH:A03.867]. + MESH:A03.867 + + + + + Anatomical cavity bounded by the derivatives of the branchial arches.[AAO] + 2012-06-20 + AAO:0000967 + AAO + AAO:EJS + + + + + Swollen region of the anterior foregut, posterior to the mouth and anterior to the liver; its walls form the jaws and gills. Kimmel et al, 1995.[TAO] + 2012-08-14 + TAO:0000056 + TAO + ZFIN:curator + + + + + Swollen region of the anterior foregut, posterior to the mouth and anterior to the liver; its walls form the jaws and gills[ZFA:0000056, ZFIN:ZDB-PUB-961014-576]. + ZFIN:ZDB-PUB-961014-576 + + + + + The portion of the alimentary canal between the mouth and the oesophagus. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG] + 2012-09-17 + VHOG:0000462 + VHOG + + + + + + relationship type change: part_of_proxy respiratory system (AAO:0000541) CHANGED TO: develops_from respiratory system (UBERON:0001004)[AAO] + 2012-06-20 + AAO:0000967 + AAO + + + + + relationship type change: part_of_proxy respiratory system (AAO:0000541) CHANGED TO: part_of respiratory system (UBERON:0001004)[AAO] + 2012-06-20 + AAO:0000967 + AAO + + + + + (...) the earliest vertebrates possessed unjointed internal and external branchial arches, and musculature encircling the pharynx.[well established][VHOG] + 2012-09-17 + VHOG:0000462 + VHOG + + ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) Box essay 13.1 and Box figure I, p.502-503 + + + + + MA/FMA pharynx not part of digestive/alimentary system, we are consistent with this scheme + MA + + + + + pharynx + FMA:46688 + + + + + + UMLS:C0031354 + ncithesaurus:Pharynx + + + + + + + + + + + + + + + Primordia are populations of contiguous cells that are morphologically distinct and already correspond in extent to a later organ/tissue[FBbt, Hartenstein, V. (2004)]. + + + AEO:0000171 + BTO:0001886 + EFO:0001652 + EHDAA2:0003171 + FBbt:00005495 + FMA:86589 + MAT:0000482 + NCIT:C34275 + UMLS:C0678727 + XAO:0003043 + uberon + bud + future organ + placode + primordia + rudiment + UBERON:0001048 + + + + primordium + + + + + + EHDAA2 + + + + + Primordia are populations of contiguous cells that are morphologically distinct and already correspond in extent to a later organ/tissue[FBbt, Hartenstein, V. (2004)]. + + BTO:0001886 + FB:DJS + FB:FBrf0089570 + + + + + UMLS:C0678727 + ncithesaurus:Primordium + + + + + placode + FBbt:00005495 + + + + + primordia + XAO:0003043 + + + + + + + + + + + + + + + + + + + In the developing vertebrate, the neural tube is the embryo's precursor to the central nervous system, which comprises the brain and spinal cord. The neural groove gradually deepens as the neural folds become elevated, and ultimately the folds meet and coalesce in the middle line and convert the groove into a closed tube, the neural tube or neural canal (which strictly speaking is the center of the neural tube), the ectodermal wall of which forms the rudiment of the nervous system. [WP,unvetted]. + Hollow epithelial tube on dorsal side of the embryo that develops into the central nervous system.[AAO] + The dorsal tubular structure in the vertebrate embryo that develops into the brain and spinal cord. [TFD][VHOG] + (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG] + The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium + + + + + AAO:0010617 + BTO:0001057 + CALOHA:TS-2371 + DHBA:10154 + EHDAA2:0001254 + EHDAA:2869 + EHDAA:908 + EMAPA:16164 + EMAPA:16757 + FMA:293882 + MAT:0000069 + MIAA:0000069 + NCIT:C34226 + TAO:0001135 + UMLS:C0231024 + VHOG:0000307 + XAO:0003204 + ZFA:0001135 + uberon + neural primordium + presumptive central nervous system + tubus neuralis + UBERON:0001049 + + + + neural tube + http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png + + + + + + EHDAA2 + + + + + In the developing vertebrate, the neural tube is the embryo's precursor to the central nervous system, which comprises the brain and spinal cord. The neural groove gradually deepens as the neural folds become elevated, and ultimately the folds meet and coalesce in the middle line and convert the groove into a closed tube, the neural tube or neural canal (which strictly speaking is the center of the neural tube), the ectodermal wall of which forms the rudiment of the nervous system. [WP,unvetted]. + + + + + + Hollow epithelial tube on dorsal side of the embryo that develops into the central nervous system.[AAO] + 2012-06-20 + AAO:0010617 + AAO + AAO:JOR + + + + + The dorsal tubular structure in the vertebrate embryo that develops into the brain and spinal cord. [TFD][VHOG] + 2012-09-17 + VHOG:0000307 + VHOG + + + + + + + (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG] + 2012-09-17 + VHOG:0000307 + VHOG + + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28 + + + + + The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium + GO:0021915 + + + + + UMLS:C0231024 + ncithesaurus:Neural_Tube + + + + + tubus neuralis + + + + + + + + + + Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species. + + AAO:0010841 + AEO:0000000 + BILA:0000000 + BIRNLEX:6 + CARO:0000000 + EHDAA2:0002229 + FBbt:10000000 + FBbt_root:00000000 + FMA:62955 + HAO:0000000 + MA:0000001 + NCIT:C12219 + TAO:0100000 + TGMA:0001822 + UMLS:C1515976 + WBbt:0000100 + XAO:0000000 + ZFA:0100000 + uberon + UBERON:0001062 + + anatomical entity + + + + + Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species. + + FMA:62955 + + + + + UMLS:C1515976 + ncithesaurus:Anatomic_Structure_System_or_Substance + + + + + + + + + + + + + + + + + + + + + + + + + + A zone of skin that is part of a back [Automatically generated definition]. + TODO - distinguish between entire skin of region and arbitrary zone of skin on region + + EMAPA:36392 + FMA:10462 + FMA:22985 + MA:0000498 + back skin + back zone of skin + skin, dorsal region + zone of skin of back + uberon + UBERON:0001068 + + skin of back + + + + + + MA + + + + + + + + + + + MA + + + + + A zone of skin that is part of a back [Automatically generated definition]. + OBOL:automatic + + + + + back zone of skin + OBOL:automatic + + + + + skin, dorsal region + + + + + + zone of skin of back + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + It ascends beneath the anterior margin of the trapezius, distributing branches to it, and to the neighboring muscles and lymph glands in the neck, and anastomosing with the superficial branch of the descending branch of the occipital artery. + + + + EMAPA:37117 + FMA:10665 + MA:0002052 + NCIT:C53005 + UMLS:C0226271 + superficial branch of transverse cervical artery + uberon + UBERON:0001071 + + The transverse cervical artery splits into two branches, a superficial one and a deep one[WP] + superficial cervical artery + + + + + It ascends beneath the anterior margin of the trapezius, distributing branches to it, and to the neighboring muscles and lymph glands in the neck, and anastomosing with the superficial branch of the descending branch of the occipital artery. + + + + + + EMAPA:37117 + MA:th + + + + + UMLS:C0226271 + ncithesaurus:Superficial_Cervical_Artery + + + + + superficial branch of transverse cervical artery + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A potential space between the visceral and parietal layers of the pericardium. + + Anatomical space in which the heart is located and is surrounded by the pericardium.[TAO] + In hagfishes a transverse septum extends upward from the ventral body wall posterior to the heart, partly separating an anterior pericardial cavity from a larger peritoneal cavity. (...) These basic relationships have not been modified by urodeles. The small pericardial cavity remains far forward where it is separated by a transverse septum from the principal coelom, which may now be called a pleuroperitoneal cavity because slender lungs are present. (...) The heart (of other tetrapods) is separated from the lungs (and liver if present) by more or less horizontal partitions that have their origin in the embryo as folds on the serous membrane of the right and left lateral body walls. These grow out to join in the midline of the body. They are called lateral mesocardia (birds) or pleuropericardial membranes. Posteriorly they join the transverse septum to form the adult pericardial membrane, or pericardium. (...) In their partitioning of their coelom, embryonic mammals resemble first early fishes (incomplete partition, posterior to heart, consisting of the transverse septum) and then reptiles (pericardium derived from transverse septum and pleuropericardial membranes). Mammals then separate paired pleural cavities from the peritoneal cavity by a diaphragm. The ventral portion of this organ comes from the transverse septum. The dorsal portion is derived from the dorsal mesentery and from still another pair of outgrowths from the lateral body wall, the pleuroperitoneal membranes.[well established][VHOG] + check ZFA, should actually be thoracic cavity. Note that Hyman defines the cavity as the space between the heart and the sac (but defines the sac as parietal) + + + + BSA:0000091 + EHDAA2:0001434 + EMAPA:16131 + EMAPA:16132 + FMA:11350 + MA:0000053 + NCIT:C38662 + TAO:0002220 + UMLS:C0225972 + VHOG:0000556 + ZFA:0001655 + galen:PericardialSpace + cavity of pericardial sac + pericardial space + uberon + cavitas pericardiaca + UBERON:0001074 + + + + pericardial cavity + + + + + + MA + + + + + + + + + + + FMA + + + + + + + + + + + Wikipedia + + + + + A potential space between the visceral and parietal layers of the pericardium. + + + + + + + + + + + + Anatomical space in which the heart is located and is surrounded by the pericardium.[TAO] + 2012-08-14 + TAO:0002220 + TAO + ZFIN:curator + + + + + In hagfishes a transverse septum extends upward from the ventral body wall posterior to the heart, partly separating an anterior pericardial cavity from a larger peritoneal cavity. (...) These basic relationships have not been modified by urodeles. The small pericardial cavity remains far forward where it is separated by a transverse septum from the principal coelom, which may now be called a pleuroperitoneal cavity because slender lungs are present. (...) The heart (of other tetrapods) is separated from the lungs (and liver if present) by more or less horizontal partitions that have their origin in the embryo as folds on the serous membrane of the right and left lateral body walls. These grow out to join in the midline of the body. They are called lateral mesocardia (birds) or pleuropericardial membranes. Posteriorly they join the transverse septum to form the adult pericardial membrane, or pericardium. (...) In their partitioning of their coelom, embryonic mammals resemble first early fishes (incomplete partition, posterior to heart, consisting of the transverse septum) and then reptiles (pericardium derived from transverse septum and pleuropericardial membranes). Mammals then separate paired pleural cavities from the peritoneal cavity by a diaphragm. The ventral portion of this organ comes from the transverse septum. The dorsal portion is derived from the dorsal mesentery and from still another pair of outgrowths from the lateral body wall, the pleuroperitoneal membranes.[well established][VHOG] + 2012-09-17 + VHOG:0000556 + VHOG + + ISBN:978-0471090588 Hildebrand M, Analysis of vertebrate structure (1983) p.205-206 + + + + + check ZFA, should actually be thoracic cavity. Note that Hyman defines the cavity as the space between the heart and the sac (but defines the sac as parietal) + ZFA + + + + + UMLS:C0225972 + ncithesaurus:Pericardial_Cavity + + + + + pericardial space + + + + + + cavitas pericardiaca + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Endocardium that is part of the cardiac ventricle. + + EMAPA:32747 + FMA:12148 + MA:0000079 + TAO:0002247 + VHOG:0000607 + ZFA:0001615 + cardiac ventricle endocardium + endocardium of cardiac ventricle + endocardium of heart ventricle + endocardium of lower chamber of heart + endocardium of ventricle of heart + heart ventricle endocardium + lower chamber of heart endocardium + ventricle endocardium + ventricle of heart endocardium + ventricular endocardium + uberon + ventricle endocardial tissue + UBERON:0001081 + + + endocardium of ventricle + + + + + + + + + + + + + + + + Endocardium that is part of the cardiac ventricle. + ZFIN:curator + + + + + cardiac ventricle endocardium + OBOL:automatic + + + + + endocardium of cardiac ventricle + OBOL:automatic + + + + + endocardium of heart ventricle + OBOL:automatic + + + + + endocardium of lower chamber of heart + OBOL:automatic + + + + + endocardium of ventricle of heart + OBOL:automatic + + + + + heart ventricle endocardium + OBOL:automatic + + + + + lower chamber of heart endocardium + OBOL:automatic + + + + + ventricle of heart endocardium + OBOL:automatic + + + + + ventricle endocardial tissue + VHOG:0000607 + + + + + + + + + + + + + + + + + + + + + + + + + + An epicardial layer that lines a cardiac ventricle + The external layer of the ventricle bounding the ventricular myocardium. It is formed by a single layer of mesothelial cells supported by a basal lamina, and imbricated with collagen, fibroblasts, and vascular structures in the subepicardial space. Hu et al. 2001.[TAO] + FMA:12150 + TAO:0005058 + ZFA:0005058 + cardiac ventricle epicardium + ventricular epicardium + uberon + UBERON:0001082 + + epicardium of ventricle + + + + + An epicardial layer that lines a cardiac ventricle + + + + + + The external layer of the ventricle bounding the ventricular myocardium. It is formed by a single layer of mesothelial cells supported by a basal lamina, and imbricated with collagen, fibroblasts, and vascular structures in the subepicardial space. Hu et al. 2001.[TAO] + 2012-08-14 + TAO:0005058 + TAO + ZFIN:curator + + + + + cardiac ventricle epicardium + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Muscular layer of the cardiac ventricle composed of a compact myocardial layer surrounding the trabecular layer. + Muscular layer of the cardiac ventricle composed of a compact myocardial layer surrounding the trabecular layer Hu et al. 2001.[TAO] + As noted, the hearts of birds and mammals have four chambers that arises from the two chambers (atrium and ventricle) of the fish heart.[uncertain][VHOG] + + EFO:0003088 + EMAPA:32748 + FMA:12151 + MA:0000082 + TAO:0005061 + VHOG:0000604 + ZFA:0005061 + ventricle myocardium + ventricular myocardium + uberon + ventricle cardiac muscle + UBERON:0001083 + + + + myocardium of ventricle + + + + + + + + + + + + + + + + Muscular layer of the cardiac ventricle composed of a compact myocardial layer surrounding the trabecular layer. + ZFIN:curator + + + + + Muscular layer of the cardiac ventricle composed of a compact myocardial layer surrounding the trabecular layer Hu et al. 2001.[TAO] + 2012-08-14 + TAO:0005061 + TAO + ZFIN:curator + + + + + As noted, the hearts of birds and mammals have four chambers that arises from the two chambers (atrium and ventricle) of the fish heart.[uncertain][VHOG] + 2012-09-17 + VHOG:0000604 + VHOG + + ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.481 + + + + + ventricle cardiac muscle + VHOG:0000604 + + + + + + + + + + + + + + + + + + + + + + + + + + A zone of skin that is part of a head [Automatically generated definition]. + TODO - distinguish between entire skin of region and arbitrary zone of skin on region + + + FMA:12166 + FMA:24756 + MA:0000582 + NCIT:C52757 + UMLS:C0205029 + adult head zone of skin + head skin + head zone of skin + zone of skin of adult head + zone of skin of head + uberon + UBERON:0001084 + skin of head + + + + + A zone of skin that is part of a head [Automatically generated definition]. + OBOL:automatic + + + + + UMLS:C0205029 + ncithesaurus:Head_Skin + + + + + adult head zone of skin + OBOL:automatic + + + + + head zone of skin + OBOL:automatic + + + + + zone of skin of adult head + OBOL:automatic + + + + + zone of skin of head + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A zone of skin that is part of a trunk [Automatically generated definition]. + TODO - distinguish between entire skin of region and arbitrary zone of skin on region + + + EMAPA:37278 + FMA:12167 + FMA:23093 + MA:0000517 + NCIT:C12295 + UMLS:C0205031 + torso zone of skin + trunk skin + trunk zone of skin + zone of skin of torso + zone of skin of trunk + uberon + UBERON:0001085 + skin of trunk + + + + + A zone of skin that is part of a trunk [Automatically generated definition]. + OBOL:automatic + + + + + EMAPA:37278 + MA:th + + + + + UMLS:C0205031 + ncithesaurus:Skin_of_the_Trunk + + + + + torso zone of skin + OBOL:automatic + + + + + trunk zone of skin + OBOL:automatic + + + + + zone of skin of torso + OBOL:automatic + + + + + zone of skin of trunk + OBOL:automatic + + + + + + + + + + + + + + + + Joint fluid is a transudate of plasma that is actively secreted by synovial cells. + Portion of organism substance that is a clear fluid that occupies the space in synovial joints.[TAO] + It provides nutrients and lubrication for articular cartilage + The fluid contains hyaluronan secreted by fibroblast-like cells in the synovial membrane, lubricin (proteoglycan 4; PRG4) secreted by the surface chondrocytes of the articular cartilage and interstitial fluid filtered from the blood plasma + + + BTO:0001339 + CALOHA:TS-0996 + ENVO:02000039 + FMA:12277 + GAID:265 + MA:0002544 + MESH:D013582 + NCIT:C33718 + TAO:0005154 + UMLS:C0039097 + ZFA:0005154 + galen:SynovialFluid + joint fluid + uberon + UBERON:0001090 + + + synovial fluid + + + + + + FMA + + + + + Joint fluid is a transudate of plasma that is actively secreted by synovial cells. + + + + + + Portion of organism substance that is a clear fluid that occupies the space in synovial joints.[TAO] + 2012-08-14 + TAO:0005154 + TAO + ZFIN:curator + + + + + UMLS:C0039097 + ncithesaurus:Synovial_Fluid + + + + + joint fluid + + + + + + + + + + + + + + + + + Muscle tissue composed of cardiac muscle cells, forming the muscles of the heart[ZFA,modified]. + check relationship with myocardium. part_of in MA - but we also have a more specific class 'cardiac muscle tissue of myocardium'. Check ncit + UBERON:0007096 + + AAO:0010245 + AEO:0000142 + BILA:0000134 + BTO:0000199 + CALOHA:TS-0440 + EHDAA2:0003142 + EMAPA:32688 + FMA:14068 + TAO:0005280 + ZFA:0005280 + galen:CardiacMuscle + galen:CardiacMuscleTissue + ncithesaurus:Heart_Muscle + cardiac muscle + cardiac muscle muscle tissue + cardiac muscle textus muscularis + heart muscle muscle tissue + heart muscle textus muscularis + heart myocardium muscle tissue + heart myocardium textus muscularis + muscle of heart muscle tissue + muscle of heart textus muscularis + muscle tissue of cardiac muscle + muscle tissue of heart muscle + muscle tissue of heart myocardium + muscle tissue of muscle of heart + muscle tissue of myocardium + myocardium muscle tissue + myocardium textus muscularis + textus muscularis of cardiac muscle + textus muscularis of heart muscle + textus muscularis of heart myocardium + textus muscularis of muscle of heart + textus muscularis of myocardium + uberon + cardiac musculature + UBERON:0001133 + + + + cardiac muscle tissue + + + + + + + + + + + ZFA + + + + + Muscle tissue composed of cardiac muscle cells, forming the muscles of the heart[ZFA,modified]. + ZFA:0005280 + + + + + cardiac muscle muscle tissue + OBOL:automatic + + + + + cardiac muscle textus muscularis + OBOL:automatic + + + + + heart muscle muscle tissue + OBOL:automatic + + + + + heart muscle textus muscularis + OBOL:automatic + + + + + heart myocardium muscle tissue + OBOL:automatic + + + + + heart myocardium textus muscularis + OBOL:automatic + + + + + muscle of heart muscle tissue + OBOL:automatic + + + + + muscle of heart textus muscularis + OBOL:automatic + + + + + muscle tissue of cardiac muscle + OBOL:automatic + + + + + muscle tissue of heart muscle + OBOL:automatic + + + + + muscle tissue of heart myocardium + OBOL:automatic + + + + + muscle tissue of muscle of heart + OBOL:automatic + + + + + muscle tissue of myocardium + OBOL:automatic + + + + + myocardium muscle tissue + OBOL:automatic + + + + + myocardium textus muscularis + OBOL:automatic + + + + + textus muscularis of cardiac muscle + OBOL:automatic + + + + + textus muscularis of heart muscle + OBOL:automatic + + + + + textus muscularis of heart myocardium + OBOL:automatic + + + + + textus muscularis of muscle of heart + OBOL:automatic + + + + + textus muscularis of myocardium + OBOL:automatic + + + + + cardiac musculature + BILA:0000134 + + + + + + + + + + Muscle tissue which is unstriated, composed primarily of smooth muscle fibers surrounded by a reticulum of collagen and elastic fibers. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length[GO]. + A non-striated muscle that is composed of spindle-shaped cells. Smooth muscle usually is organized into sheets that line cavitated organs.[TAO] + Involuntary muscle tissue consisting of uninucleate spindle-shaped fibers.[AAO] + (...) the first bilateral animals possessed only smooth muscles with the molecular repertoire necessary to build a striated muscle. (...) it is more parsimonious to regard striated muscle cells as a sister cell type to the smooth muscle cells. In this scenario, striated and smooth muscles would have arisen in the stem lineage that led to the Nephrozoa (i.e. all Bilateria exclusive the acoelomorphs) (Hejnol et al., 2009), from an 'acoel-like' smooth muscle, by segregation and divergence of functions and through differential recruitment of additional genes[well established][VHOG] + GO uses visceral and smooth interchangeably. However visceral can also be used in the sense of the viscera. Many fly annotations to smooth muscle terms. If we want to be inclusive of insects have to have a general definition of tissue that includes cells. + + + AAO:0010244 + AEO:0000141 + BTO:0001260 + CALOHA:TS-0943 + EFO:0000889 + EHDAA2:0003141 + EMAPA:32717 + EV:0100378 + FBbt:00003525 + FMA:14070 + GAID:167 + MA:0000166 + MAT:0000303 + MESH:D009130 + MIAA:0000303 + NCIT:C12437 + OpenCyc:Mx4rvvSS3pwpEbGdrcN5Y29ycA + TAO:0005274 + UMLS:C1267092 + VHOG:0001246 + WBbt:0005781 + XAO:0000175 + ZFA:0005274 + galen:SmoothMuscle + galen:SmoothMuscleTissue + involuntary muscle + non-striated muscle + smooth muscle + textus muscularis nonstriatus + visceral muscle + visceral muscle tissue + uberon + textus muscularis levis; textus muscularis nonstriatus + UBERON:0001135 + + + + + smooth muscle tissue + Glatte:Muskelzellen.jpg + + + + + Muscle tissue which is unstriated, composed primarily of smooth muscle fibers surrounded by a reticulum of collagen and elastic fibers. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length[GO]. + + GO:0006939 + + + + + A non-striated muscle that is composed of spindle-shaped cells. Smooth muscle usually is organized into sheets that line cavitated organs.[TAO] + 2012-08-14 + TAO:0005274 + TAO + ZFIN:curator + + + + + Involuntary muscle tissue consisting of uninucleate spindle-shaped fibers.[AAO] + 2012-06-20 + AAO:0010244 + AAO + AAO:CAM + + + + + (...) the first bilateral animals possessed only smooth muscles with the molecular repertoire necessary to build a striated muscle. (...) it is more parsimonious to regard striated muscle cells as a sister cell type to the smooth muscle cells. In this scenario, striated and smooth muscles would have arisen in the stem lineage that led to the Nephrozoa (i.e. all Bilateria exclusive the acoelomorphs) (Hejnol et al., 2009), from an 'acoel-like' smooth muscle, by segregation and divergence of functions and through differential recruitment of additional genes[well established][VHOG] + 2012-09-17 + VHOG:0001246 + VHOG + + DOI:10.1002/jez.b.21416 Chiodin M, Achatz JG, Wanninger A, Martinez P, Molecular architecture of muscles in an acoel and its evolutionary implications. Journal of Experimental Zoology (2011) + + + + + UMLS:C1267092 + ncithesaurus:Smooth_Muscle_Tissue + + + + + textus muscularis nonstriatus + FMA:14070 + FMA:TA + + + + + + visceral muscle + + + + + + visceral muscle tissue + + + + + + textus muscularis levis; textus muscularis nonstriatus + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Simple squamous epithelium of mesodermal origin which lines serous membranes. Examples: mesothelium of pleura, mesothelium of peritoneum[FMA]. Wikipedia: The mesothelium is a membrane that forms the lining of several body cavities: the pleura (thoracal cavity), peritoneum (abdominal cavity including the mesentery) and pericardium (heart sac). Mesothelial tissue also surrounds the male internal reproductive organs (the tunica vaginalis testis) and covers the internal reproductive organs of women (the tunica serosa uteri). + + + + AEO:0000111 + BTO:0002422 + CALOHA:TS-1183 + EHDAA2_RETIRED:0003111 + EHDAA:2331 + EHDAA:2349 + EHDAA:295 + EHDAA:6073 + EHDAA:640 + EHDAA:646 + EMAPA:32856 + FMA:14074 + MA:0000565 + NCIT:C33105 + UMLS:C0086610 + uberon + UBERON:0001136 + + mesothelium + http://upload.wikimedia.org/wikipedia/commons/2/25/Mesothelium_peritoneal_wash_high_mag.jpg + + + + + Simple squamous epithelium of mesodermal origin which lines serous membranes. Examples: mesothelium of pleura, mesothelium of peritoneum[FMA]. Wikipedia: The mesothelium is a membrane that forms the lining of several body cavities: the pleura (thoracal cavity), peritoneum (abdominal cavity including the mesentery) and pericardium (heart sac). Mesothelial tissue also surrounds the male internal reproductive organs (the tunica vaginalis testis) and covers the internal reproductive organs of women (the tunica serosa uteri). + + FMA:14074 + + + + + UMLS:C0086610 + ncithesaurus:Mesothelium + + + + + + + + + A major subdivision of an organism that is the entire part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane. In vertebrares this includes the vertebral column.. + dorsal + In humans, called the back, a large posterior area of the human body, rising from the top of the buttocks to the back of the neck and the shoulders. It is the surface opposite to the chest, its height being defined by the vertebral column (commonly referred to as the spine or backbone) and its breadth being supported by the ribcage and shoulders. The spinal canal runs through the spine and provides nerves to the rest of the body + + + + BTO:0001713 + CALOHA:TS-2223 + EFO:0001405 + FMA:14181 + GAID:30 + MESH:A01.176 + NCIT:C13062 + OpenCyc:Mx4rvVkEU5wpEbGdrcN5Y29ycA + UMLS:C0004600 + galen:Back + back + back of body proper + dorsal part of organism + uberon + UBERON:0001137 + + + dorsum + http://upload.wikimedia.org/wikipedia/commons/e/ee/432px-Gray-back.PNG + + + + + A major subdivision of an organism that is the entire part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane. In vertebrares this includes the vertebral column.. + + BSPO:0000063 + UBERONREF:0000006 + + + + + UMLS:C0004600 + ncithesaurus:Back + + + + + back + FMA:14181 + + + + + back of body proper + FMA:14181 + + + + + + + + + + + + + + + + + + + + + + + + + + A zone of skin that is part of a neck [Automatically generated definition]. + + + EMAPA:37277 + FMA:23021 + FMA:23022 + MA:0000590 + NCIT:C52756 + UMLS:C0205030 + neck (volume) zone of skin + neck skin + neck zone of skin + zone of skin of neck + zone of skin of neck (volume) + uberon + UBERON:0001417 + skin of neck + + + + + A zone of skin that is part of a neck [Automatically generated definition]. + OBOL:automatic + + + + + EMAPA:37277 + MA:th + + + + + UMLS:C0205030 + ncithesaurus:Neck_Skin + + + + + neck (volume) zone of skin + OBOL:automatic + + + + + neck zone of skin + OBOL:automatic + + + + + zone of skin of neck + OBOL:automatic + + + + + zone of skin of neck (volume) + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A zone of skin that is part of a thorax [Automatically generated definition]. + + EMAPA:37765 + FMA:23028 + FMA:23029 + MA:0000564 + thoracic skin + thorax skin + thorax zone of skin + zone of skin of thorax + uberon + upper body skin + UBERON:0001418 + skin of thorax + + + + + A zone of skin that is part of a thorax [Automatically generated definition]. + OBOL:automatic + + + + + EMAPA:37765 + MA:th + + + + + thorax zone of skin + OBOL:automatic + + + + + zone of skin of thorax + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Anatomical system that is a multi-element, multi-tissue anatomical cluster that consists of the skeleton and the articular system. + Anatomical system consisting of multiple elements and tissues that provides physical support.[TAO] + Anatomical system that is a multi-element, multi-tissue anatomical cluster that consists of the skeleton and the articular system.[VSAO] + System that provides physical support to the organism.[AAO] + By taking a holistic approach, integration of the evidence from molecular and developmental features of model organisms, the phylogenetic distribution in the 'new animal phylogeny' and the earliest fossilized remains of mineralized animal skeletons suggests independent origins of the skeleton at the phylum level.[debated][VHOG] + skeletal + GO defines skeletal system very generically: The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton) GO:0001501; however, all annotations are to vertebrates + + AAO:0000566 + BTO:0001486 + CALOHA:TS-1320 + EFO:0000806 + EHDAA2:0003168 + EMAPA:35773 + FMA:23881 + MA:0000018 + NCIT:C12788 + OpenCyc:Mx4rvVi1rpwpEbGdrcN5Y29ycA + TAO:0000434 + UMLS:C0037253 + VHOG:0001254 + VSAO:0000027 + XAO:0003060 + ZFA:0000434 + skeleton system + set of all bones and joints + uberon + Skelettsystem + UBERON:0001434 + + + + + skeletal system + https://github.com/obophenotype/uberon/wiki/The-skeletal-system + + + + + Anatomical system that is a multi-element, multi-tissue anatomical cluster that consists of the skeleton and the articular system. + + GO_REF:0000034 + VSAO:0000027 + + + + + Anatomical system consisting of multiple elements and tissues that provides physical support.[TAO] + 2012-08-14 + TAO:0000434 + TAO + TAO:wd + + + + + Anatomical system that is a multi-element, multi-tissue anatomical cluster that consists of the skeleton and the articular system.[VSAO] + 2012-08-14 + VSAO:0000027 + VSAO + GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 + PSPUB:0000170 + + + + + System that provides physical support to the organism.[AAO] + 2012-06-20 + AAO:0000566 + AAO + AAO:LAP + + + + + By taking a holistic approach, integration of the evidence from molecular and developmental features of model organisms, the phylogenetic distribution in the 'new animal phylogeny' and the earliest fossilized remains of mineralized animal skeletons suggests independent origins of the skeleton at the phylum level.[debated][VHOG] + 2012-09-17 + VHOG:0001254 + VHOG + + DOI:10.1159/000324245 Donoghue PCJ, Sansom IJ, Origin and early evolution of vertebrate skeletonization. Microscopy research and technique (2002) + + + + + GO defines skeletal system very generically: The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton) GO:0001501; however, all annotations are to vertebrates + GO + + + + + UMLS:C0037253 + ncithesaurus:Skeletal_System + + + + + set of all bones and joints + + + + + + Skelettsystem + BTO:0001486 + + + + + + + + + + + + + + + + FMA:24218 + XAO:0000040 + head subdivision + uberon + head region + region of head + UBERON:0001444 + + subdivision of head + + + + + + + + + + + + + + + + + + + + + A subdivision of the head that has as parts the layers deep to the surface of the anterior surface, including the mouth, eyes, and nose (when present). In vertebrates, this includes the facial skeleton and structures superficial to the facial skeleton (cheeks, mouth, eyeballs, skin of face, etc). + Subdivision of head which consists of the viscerocranium and all layers superficial to it. Examples: There is only one face. + The area that extends from the median ocellus to the oral foramen[HAO]. + facial + The face develops from outward growth of tissue located rostral to the cranium & pharynx. The lower jaw and most of the upper jaw are formed by growth of the first pharyngeal (branchial) arch. The upper incisor region and the nose and forehead (frontal region) are formed from tissue located rostral to the neural tube (frontonasal prominence) + + + + BTO:0003369 + CALOHA:TS-2216 + EMAPA:32763 + FMA:24728 + GAID:64 + HAO:0000316 + MA:0002473 + MESH:D005145 + NCIT:C13071 + OpenCyc:Mx4rvVi5GZwpEbGdrcN5Y29ycA + UMLS:C0015450 + galen:Face + uberon + facia/facies + visage + UBERON:0001456 + + + face + http://upload.wikimedia.org/wikipedia/commons/5/55/Mona_Lisa_headcrop.jpg + + + + + A subdivision of the head that has as parts the layers deep to the surface of the anterior surface, including the mouth, eyes, and nose (when present). In vertebrates, this includes the facial skeleton and structures superficial to the facial skeleton (cheeks, mouth, eyeballs, skin of face, etc). + + + + + + Subdivision of head which consists of the viscerocranium and all layers superficial to it. Examples: There is only one face. + FMA:24728 + + + + + The area that extends from the median ocellus to the oral foramen[HAO]. + + HAO:0000316 + NCBITaxon:7399 + + + + + The face develops from outward growth of tissue located rostral to the cranium & pharynx. The lower jaw and most of the upper jaw are formed by growth of the first pharyngeal (branchial) arch. The upper incisor region and the nose and forehead (frontal region) are formed from tissue located rostral to the neural tube (frontonasal prominence) + vanat.cvm.umn.edu/TFFlectPDFs/LectFaceDevelop.pdf + + + + + UMLS:C0015450 + ncithesaurus:Face + + + + + facia/facies + + + + + + + visage + BTO:0003369 + + + + + + + + + + + + + + + + + + + + + + + + + + A zone of skin that is part of a lip [Automatically generated definition]. + + + EMAPA:37643 + FMA:24764 + MA:0001579 + NCIT:C12291 + UMLS:C0222101 + lip skin + lip zone of skin + zone of skin of lip + uberon + skin of lips + UBERON:0001458 + skin of lip + + + + + A zone of skin that is part of a lip [Automatically generated definition]. + OBOL:automatic + + + + + EMAPA:37643 + MA:th + + + + + UMLS:C0222101 + ncithesaurus:Skin_of_the_Lip + + + + + lip zone of skin + OBOL:automatic + + + + + zone of skin of lip + OBOL:automatic + + + + + skin of lips + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An articular capsule (or joint capsule) is an envelope surrounding a synovial joint. [WP,unvetted]. + check ncita + + + + EMAPA:37621 + FMA:34836 + GAID:263 + MA:0001519 + MESH:D017746 + NCIT:C32259 + NCIT:C84388 + UMLS:C0206207 + galen:JointCapsule + capsula articularis + fibrous capsule of joint + joint capsule + joint fibrous capsule + uberon + capsulae articulares + UBERON:0001484 + + + articular capsule + http://upload.wikimedia.org/wikipedia/commons/1/19/Joint.png + http://upload.wikimedia.org/wikipedia/commons/4/4a/Gray299.png + + + + + An articular capsule (or joint capsule) is an envelope surrounding a synovial joint. [WP,unvetted]. + + + + + + check ncita + ncit + + + + + EMAPA:37621 + MA:th + + + + + UMLS:C0206207 + ncithesaurus:Joint_Capsule + + + + + capsula articularis + FMA:34836 + FMA:TA + + + + + + capsulae articulares + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A tube extending from the mouth to the anus. + The alimentary or digestive tract, and associated organs.[TAO] + The bilaterian gut is typically a complete tube that opens to the exterior at both ends. It consists of mouth, foregut, midgut, hindgut, and anus (reference 1); Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut (reference 2).[well established][VHOG] + FMA also has a term 'gastrointestinal tract', but this includes the liver. + we place the MA and EMAPA class here, although the intent is probably a smaller region. See https://github.com/obophenotype/uberon/issues/509 + we following Kardong in naming the entire tube from mouth to anus the alimentary canal. Kardong calls the portion of this tract that excludes buccal cavity and pharynx the 'alimentary canal', consider adding an extra class for this + gut + + AAO:0010023 + BILA:0000083 + BTO:0000511 + BTO:0000545 + EHDAA2:0000726 + EHDAA:518 + EMAPA:16247 + FBbt:00003125 + FMA:45615 + MA:0000917 + NCIT:C34082 + OpenCyc:Mx4rvVi0GpwpEbGdrcN5Y29ycA + TAO:0000112 + TGMA:0001819 + UMLS:C0017189 + VHOG:0000309 + WBbt:0005743 + ZFA:0000112 + galen:AlimentaryTract + digestive tube + enteric tract + alimentary canal + alimentary tract + uberon + digestive canal + gut tube + UBERON:0001555 + + + digestive tract + + + + + + + + + + + NCBIBook:NBK10107 + + + + + A tube extending from the mouth to the anus. + + + + + + + The alimentary or digestive tract, and associated organs.[TAO] + 2012-08-14 + TAO:0000112 + TAO + ZFIN:curator + + + + + The bilaterian gut is typically a complete tube that opens to the exterior at both ends. It consists of mouth, foregut, midgut, hindgut, and anus (reference 1); Although all vertebrates have a digestive tract and accessory glands, various parts of this system are not necessarily homologous, analogous, or even present in all species. Therefore, broad comparisons can be best made under the listings of headgut, foregut, midgut, pancreas and biliary system, hindgut (reference 2).[well established][VHOG] + 2012-09-17 + VHOG:0000309 + VHOG + + ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.203, ISBN:978-0521617147 Stevens CE and Hume ID, Comparative physiology of the vertebrate digestive system (2004) p.11 + + + + + FMA also has a term 'gastrointestinal tract', but this includes the liver. + FMA + + + + + we place the MA and EMAPA class here, although the intent is probably a smaller region. See https://github.com/obophenotype/uberon/issues/509 + MA + + + + + UMLS:C0017189 + ncithesaurus:Gastrointestinal_Tract + + + + + enteric tract + ZFA:0000112 + + + + + digestive canal + BTO:0000058 + + + + + + + + + + + + + + + + + + + + + One of two jugular veins that collect the blood from the brain, the superficial parts of the face, and the neck. [WP,unvetted]. + Vein which receives many veins draining the palate, brain, and the orbital, nasal, and auditory regions.[AAO] + + + + AAO:0010236 + EHDAA2:0000877 + EHDAA:5407 + EMAPA:17620 + FMA:4724 + MA:0002157 + NCIT:C32849 + OpenCyc:Mx4rvqdb95wpEbGdrcN5Y29ycA + RETIRED_EHDAA2:0000878 + UMLS:C0226550 + XAO:0000382 + galen:InternalJugularVein + internal jugular + internal jugular venous tree + uberon + vena jugularis interna + UBERON:0001586 + + internal jugular vein + http://upload.wikimedia.org/wikipedia/commons/e/e9/Gray562.png + + + + + One of two jugular veins that collect the blood from the brain, the superficial parts of the face, and the neck. [WP,unvetted]. + + + + + + Vein which receives many veins draining the palate, brain, and the orbital, nasal, and auditory regions.[AAO] + 2012-06-20 + AAO:0010236 + AAO + AAO:BJB + + + + + UMLS:C0226550 + ncithesaurus:Internal_Jugular_Vein + + + + + internal jugular + EHDAA2:0000877 + + + + + vena jugularis interna + + + + + + + + + + + + + + + + + + + The ciliary muscle is a ring of smooth muscle in the middle layer of the eye that controls the eye's accommodation for viewing objects at varying distances and regulates the flow of aqueous humour through Schlemm's canal. [WP,unvetted]. + + + + BTO:0000654 + EMAPA:35240 + FMA:49151 + MA:0001269 + NCIT:C32315 + UMLS:C0559230 + musculus ciliarus + uberon + Bowman`s muscles + ciliaris + musculus ciliaris + UBERON:0001605 + + + ciliary muscle + http://upload.wikimedia.org/wikipedia/commons/2/28/Gray872.png + + + + + + MA + + + + + + FMA + + + + + + + + + + + FMA + + + + + The ciliary muscle is a ring of smooth muscle in the middle layer of the eye that controls the eye's accommodation for viewing objects at varying distances and regulates the flow of aqueous humour through Schlemm's canal. [WP,unvetted]. + + + + + + UMLS:C0559230 + ncithesaurus:Ciliary_Muscle + + + + + musculus ciliarus + BTO:0000654 + + + + + Bowman`s muscles + BTO:0000654 + + + + + ciliaris + + + + + + musculus ciliaris + + + + + + + + + + + + + + + + + + + + + + + + + + + + . + revisit this, see issue #331 + The muscle cells of the iris are smooth muscle in mammals and amphibians, but are striated muscle in birds and reptiles. Many fish have neither, and, as a result, their irides are unable to dilate and contract, so that the pupil always remains of a fixed size[Romer, via WP] + in aves, stromal mesenchymal cells may migrate to the iris and become skeletal + + + EMAPA:35448 + FMA:49154 + MA:0001287 + iris muscle + iris muscle organ + muscle organ of iris + uberon + UBERON:0001606 + + muscle of iris + + + + + + FMA + + + + + . + + + + + + iris muscle organ + OBOL:automatic + + + + + muscle organ of iris + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work[GO]. + Portion of tissue composed of contractile fibers.[TAO] + It seems clear that the metazoan ancestor inherited from its unicellular descendants an actin cytoskeleton and motor-proteins of the myosin superfamily. Within metazoans, these two molecules were arranged into effective contractile units, the muscles. The basic trends for muscle evolution are already expressed in the diploblastic taxa.[well established][VHOG] + muscular + muscle + + AAO:0011066 + EMAPA:32715 + EMAPA:37474 + EV:0100146 + FMA:5022 + GAID:131 + MA:0000015 + OpenCyc:Mx4rv2kf-5wpEbGdrcN5Y29ycA + TAO:0005145 + VHOG:0001245 + XAO:0000172 + ZFA:0005145 + galen:Muscle + uberon + UBERON:0001630 + + + + + muscle organ + + + + + Organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work[GO]. + GO:0007517 + + + + + Portion of tissue composed of contractile fibers.[TAO] + 2012-08-14 + TAO:0005145 + TAO + ZFIN:curator + + + + + It seems clear that the metazoan ancestor inherited from its unicellular descendants an actin cytoskeleton and motor-proteins of the myosin superfamily. Within metazoans, these two molecules were arranged into effective contractile units, the muscles. The basic trends for muscle evolution are already expressed in the diploblastic taxa.[well established][VHOG] + 2012-09-17 + VHOG:0001245 + VHOG + + ISBN:978-0198566694 Schmidt-Rhaesa A, The evolution of organ systems (2007) p.75 + + + + + muscle + ZFA:0005145 + + + + + EMAPA:37474 + MA:th + + + + + + + + + + + + + + + An epithelial tube or tree of tibes that transports blood away from the heart[modified from AEO definition]. + Note that in FMA an artery is a tree, whereas AEO/JB defines it as a tube; FMA includes a separate class for what it calls the trunk. Classification in this ontology may currently (Jan 2012) represent a mix of both schemes, although we are gradually revising in the direction of the AEO scheme. + Part of the circulatory system composed of blood vessels which carry oxygenated blood away from the heart to the rest of the body.[AAO] + The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG] + arterial + + + + + AAO:0010211 + AEO:0000208 + BTO:0000573 + CALOHA:TS-0054 + EFO:0000814 + EHDAA2:0000143 + EHDAA2:0003253 + EMAPA:35147 + EV:0100026 + FMA:50720 + GAID:468 + MA:0000064 + MAT:0000034 + MESH:D001158 + MIAA:0000034 + NCIT:C12372 + OpenCyc:Mx4rvVjknZwpEbGdrcN5Y29ycA + TAO:0000005 + UMLS:C0003842 + VHOG:0001251 + XAO:0000114 + ZFA:0000005 + galen:Artery + arterial subtree + arterial tree organ part + arteries + uberon + arterial system + arterial vessel + UBERON:0001637 + + + + + artery + + + + + An epithelial tube or tree of tibes that transports blood away from the heart[modified from AEO definition]. + AEO:JB + + + + + Part of the circulatory system composed of blood vessels which carry oxygenated blood away from the heart to the rest of the body.[AAO] + 2012-06-20 + AAO:0010211 + AAO + AAO:BJB + + + + + The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG] + 2012-09-17 + VHOG:0001251 + VHOG + + DOI:10.1196/annals.1341.002 Bishopric NH, Evolution of the heart from bacteria to man. Annals of the New York Academy of Sciences (2006) + + + + + UMLS:C0003842 + ncithesaurus:Artery + + + + + arteries + TAO:0000005 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any of the tubular branching vessels that carry blood from the capillaries toward the heart. + TODO - check with MA - vein vs venous blood vessel + Part of the circulatory system composed of blood vessels which carry blood from other organs, tissues, and cells to the heart.[AAO] + The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG] + venous + + venous subtree + venous vessel + + + + AAO:0010212 + AEO:0000209 + BTO:0000234 + CALOHA:TS-1108 + EFO:0000816 + EHDAA2:0003254 + EMAPA:35906 + EV:0100031 + FMA:50723 + GAID:492 + MA:0000067 + MAT:0000037 + MESH:D014680 + MIAA:0000037 + NCIT:C12814 + OpenCyc:Mx4rvVjkWpwpEbGdrcN5Y29ycA + TAO:0000082 + UMLS:C0042449 + VHOG:0001743 + XAO:0000115 + ZFA:0000082 + galen:Vein + venous tree organ part + uberon + vascular element + vena + venae + UBERON:0001638 + + + + + vein + http://upload.wikimedia.org/wikipedia/commons/c/c2/Venous_system_en.svg + + + + + Any of the tubular branching vessels that carry blood from the capillaries toward the heart. + + + + + + Part of the circulatory system composed of blood vessels which carry blood from other organs, tissues, and cells to the heart.[AAO] + 2012-06-20 + AAO:0010212 + AAO + AAO:BJB + + + + + The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG] + 2012-09-17 + VHOG:0001743 + VHOG + + DOI:10.1196/annals.1341.002 Bishopric NH, Evolution of the heart from bacteria to man. Annals of the New York Academy of Sciences (2006) + + + + + UMLS:C0042449 + ncithesaurus:Vein + + + + + vascular element + EMAPA:th + + + + + vena + + + + + + + venae + VHOG:0001743 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The anterior facial vein (facial vein) commences at the side of the root of the nose, and is a direct continuation of the angular vein where it also receives a small nasal branch. It lies behind the facial artery and follows a less tortuous course. It receives blood from the external palatine vein before it either joins the anterior branch of the retromandibular vein to form the common facial vein, or drains directly into the internal jugular vein. [WP,unvetted]. + Vein which collects blood from muscles of the head and drains into the external jugular vein.[AAO] + MA and NCITA also has 'anterior facial vein' + + + + AAO:0010513 + EMAPA:19220 + FMA:50874 + MA:0002115 + NCIT:C32579 + OpenCyc:Mx4rvziz3JwpEbGdrcN5Y29ycA + UMLS:C0226532 + face vein + vein of face + uberon + anterior facial vein + vena facialis anterior + UBERON:0001653 + + facial vein + http://upload.wikimedia.org/wikipedia/commons/8/8c/Gray557.png + + + + + + + + + + + FMA + + + + + The anterior facial vein (facial vein) commences at the side of the root of the nose, and is a direct continuation of the angular vein where it also receives a small nasal branch. It lies behind the facial artery and follows a less tortuous course. It receives blood from the external palatine vein before it either joins the anterior branch of the retromandibular vein to form the common facial vein, or drains directly into the internal jugular vein. [WP,unvetted]. + + + + + + Vein which collects blood from muscles of the head and drains into the external jugular vein.[AAO] + 2012-06-20 + AAO:0010513 + AAO + AAO:BJB + + + + + MA and NCITA also has 'anterior facial vein' + MA + + + + + UMLS:C0226532 + ncithesaurus:Facial_Vein + + + + + face vein + OBOL:automatic + + + + + vein of face + OBOL:automatic + + + + + anterior facial vein + + + + + + + vena facialis anterior + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The cerebral veins are divisible into external and internal groups according to the outer surfaces or the inner parts of the hemispheres they drain into. The external veins are the superior cerebral veins, inferior cerebral veins, and middle cerebral vein. [WP,unvetted]. + + + + + EMAPA:37140 + FMA:50981 + GAID:530 + MA:0002096 + MESH:D002550 + NCIT:C53037 + UMLS:C0007797 + XAO:0004160 + uberon + venae cerebri + venae encephali + UBERON:0001663 + + cerebral vein + http://upload.wikimedia.org/wikipedia/commons/9/9f/Gray568.png + + + + + The cerebral veins are divisible into external and internal groups according to the outer surfaces or the inner parts of the hemispheres they drain into. The external veins are the superior cerebral veins, inferior cerebral veins, and middle cerebral vein. [WP,unvetted]. + + + + + + EMAPA:37140 + MA:th + + + + + UMLS:C0007797 + ncithesaurus:Cerebral_Vein + + + + + venae cerebri + + + + + + + venae encephali + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Subdivision of skeleton which includes upper and lower jaw skeletons. + TODO - move ZFA:0001227 (it is the entire jaw skeleton). + Skeletal and cartilage elements of the first pharyngeal arch.[TAO] + There are cellular contributions from all three embryonic germ layers: pharyngeal mesoderm, endoderm and neural crest that migrates out of the ectoderm (Noden, 1983). + in FMA, the jaw is an organism subdivision cluster, and includes mucosal tissue such as the gingiva as parts. It appears to be skeletal in MA (and has teeth as parts). It is reasonable to assume that ZFA and XAO consider the upper and lower jaws to be skeletal elements or clusters. EHDAA2 also considers these clusters. TODO - follow EHDAA2 model. These arbitrary differences in terminology and classification have to be reconciled with the genuine well-known biological differences in the skeletal elements across vertebrates + + + + AAO:0000988 + BTO:0001749 + EMAPA:35455 + FMA:54396 + GAID:214 + MA:0001905 + MESH:D007568 + NCIT:C48821 + OpenCyc:Mx4rvVjjEZwpEbGdrcN5Y29ycA + TAO:0001227 + UMLS:C0022359 + ZFA:0001227 + galen:Jaw + jaw + jaw cartilage + mandibular arch skeleton + uberon + anterior splanchnocranium + jaws + mandibular arch + oral jaw skeleton + pharyngeal arch 1 skeleton + visceral arch 1 + UBERON:0001708 + + + + jaw skeleton + + + + + + + + + + + cjm + + + + + Subdivision of skeleton which includes upper and lower jaw skeletons. + + + + + + + Skeletal and cartilage elements of the first pharyngeal arch.[TAO] + 2012-08-14 + TAO:0001227 + TAO + ZFIN:curator + + + + + in FMA, the jaw is an organism subdivision cluster, and includes mucosal tissue such as the gingiva as parts. It appears to be skeletal in MA (and has teeth as parts). It is reasonable to assume that ZFA and XAO consider the upper and lower jaws to be skeletal elements or clusters. EHDAA2 also considers these clusters. TODO - follow EHDAA2 model. These arbitrary differences in terminology and classification have to be reconciled with the genuine well-known biological differences in the skeletal elements across vertebrates + FMA + + + + + UMLS:C0022359 + ncithesaurus:Jaw + + + + + jaw + MA:0001905 + + + + + jaw cartilage + ZFA:0001227 + + + + + mandibular arch skeleton + ZFA:0001227 + + + + + mandibular arch + TAO:0001227 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Subdivision of head that consists of the lower jaw skeletal elements plus associated soft tissue (skin, lips, muscle)[cjm]. + Inferior mandibular arch located on the anterior and lateral sides of the skull.[AAO] + Subsequent vertebrate evolution has also involved major alterations to the pharynx; perhaps the most notable occurred with the evolution of the gnathostomes. This involved substantial modifications to the most anterior pharyngeal segments, with the jaw forming from the first, anterior, pharyngeal segment, while the second formed its supporting apparatus, the hyoid.[well established][VHOG] + Note isa/partof difference MA/FMA + + + AAO:0000272 + EFO:0003660 + EHDAA2:0001018 + EHDAA:7995 + EMAPA:17906 + FMA:59398 + MESH:D008334 + VHOG:0000453 + ncithesaurus:Lower_Jaw + mandibular part of mouth + uberon + lower part of mouth + mandibular series + UBERON:0001710 + + + + See notes for jaw w.r.t skeletal element vs subdivision of head + lower jaw region + http://upload.wikimedia.org/wikipedia/commons/6/64/Gray176.png + + + + + + + + + + + + + + + + Subdivision of head that consists of the lower jaw skeletal elements plus associated soft tissue (skin, lips, muscle)[cjm]. + + + + + + Inferior mandibular arch located on the anterior and lateral sides of the skull.[AAO] + 2012-06-20 + AAO:0000272 + AAO + AAO:LAP + + + + + Subsequent vertebrate evolution has also involved major alterations to the pharynx; perhaps the most notable occurred with the evolution of the gnathostomes. This involved substantial modifications to the most anterior pharyngeal segments, with the jaw forming from the first, anterior, pharyngeal segment, while the second formed its supporting apparatus, the hyoid.[well established][VHOG] + 2012-09-17 + VHOG:0000453 + VHOG + + DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) + + + + + Note isa/partof difference MA/FMA + MA + + + + + mandibular part of mouth + FMA:59398 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A anatomical space that is enclosed by a pharynx. + See notes for pharynx - as a grouping class this is probably too bad. We exclude WBbt:0005790 (pharyngeal lumen) because of the developmental relationship + TOODO check + + AAO:0010435 + BSA:0000113 + BTO:0002097 + EMAPA:18381 + FMA:54935 + XAO:0000105 + lumen of pharynx + pharyngeal cavity + uberon + cavitas pharyngealis + cavitas pharyngis + UBERON:0001731 + cavity of pharynx + + + + + + + + + + + XAO + + + + + A anatomical space that is enclosed by a pharynx. + OBOL:automatic + + + + + cavitas pharyngealis + + + + + + cavitas pharyngis + BTO:0002097 + + + + + + + + + + + + + + + + + + + + + the space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens + The part of the eyeball between the cornea and the iris, filled with aqueous humor. [TFD][VHOG] + space in EHDAA2 - consider adding Cavity of anterior chamber of eyeball + + + + BTO:0002084 + EHDAA2:0000129 + EHDAA:9033 + EMAPA:18231 + FMA:58078 + GAID:889 + MA:0000262 + MESH:D000867 + NCIT:C12667 + UMLS:C0003151 + VHOG:0001431 + anterior chamber + anterior chamber of eye + camera anterior + eye anterior chamber + uberon + camera anterior bulbi + camera anterior bulbi oculi + camera oculi anterior + UBERON:0001766 + + anterior chamber of eyeball + http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg + + + + + + FMA + + + + + the space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens + MESH:A09.371.060.067 + MP:0005205 + + + + + The part of the eyeball between the cornea and the iris, filled with aqueous humor. [TFD][VHOG] + 2012-09-17 + VHOG:0001431 + VHOG + + + + + + + space in EHDAA2 - consider adding Cavity of anterior chamber of eyeball + EHDAA2 + + + + + UMLS:C0003151 + ncithesaurus:Anterior_Chamber_of_the_Eye + + + + + anterior chamber + HP:0000593 + MP:0010709 + + + + + camera anterior bulbi + BTO:0002084 + + + + + camera anterior bulbi oculi + + + + + + + camera oculi anterior + BTO:0002084 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + the pigmented middle of the three concentric layers that make up an eye, consisting of the iris, ciliary body and choroid[WP,edited]. + TODO - check child terms, isa vs partof. See also MA:0001284 ! tunica vasculosa plexus + + uveal + + + + CALOHA:TS-2228 + EMAPA:35901 + FMA:58103 + GAID:912 + MA:0002480 + MESH:D014602 + NCIT:C12811 + UMLS:C0042160 + tunica vasculosa of eyeball + uvea + uveal tract + uberon + pars iridica retinae + tunica vasculatis oculi + tunica vasculosa bulbi + vascular layer of eyeball + UBERON:0001768 + + + uvea + http://upload.wikimedia.org/wikipedia/commons/e/eb/Gray869.png + + + + + + FMA + + + + + the pigmented middle of the three concentric layers that make up an eye, consisting of the iris, ciliary body and choroid[WP,edited]. + + MP:0005197 + + + + + + + + + + + UMLS:C0042160 + ncithesaurus:Uvea + + + + + tunica vasculosa of eyeball + FMA:58103 + + + + + uvea + FMA:58103 + + + + + uveal tract + FMA:58103 + + + + + pars iridica retinae + + + + + + tunica vasculatis oculi + + + + + + tunica vasculosa bulbi + + + + + + + vascular layer of eyeball + FMA:58103 + + + + + + + + + + + + + + + + + + + + + + + + + + + + the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye + The opaque muscular contractile diaphragm suspended in the aqueous humour in front of the lens of the eye. The organ is perforated by the pupil and continues peripherally with the ciliary body. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG] + The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG] + iridial + The avian iris and ciliary body undergoes a transition from smooth-to-striated muscle during embryonic development [DOI:dx.doi.org/10.1006/dbio.1998.9019] + + + + AAO:0010347 + BTO:0000653 + CALOHA:TS-0491 + EFO:0004245 + EMAPA:19154 + EV:0100345 + FMA:58235 + GAID:917 + MA:0000273 + MESH:D007498 + NCIT:C12737 + OpenCyc:Mx4rvVjbppwpEbGdrcN5Y29ycA + TAO:0001238 + UMLS:C0022077 + VHOG:0000101 + XAO:0000185 + ZFA:0001238 + uberon + anterior uvea + irides + irises + UBERON:0001769 + + + + + iris + + + + + + + + + + + XAO + + + + + the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye + ISBN:0-683-40008-8 + MP:0001322 + + + + + The opaque muscular contractile diaphragm suspended in the aqueous humour in front of the lens of the eye. The organ is perforated by the pupil and continues peripherally with the ciliary body. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG] + 2012-09-17 + VHOG:0000101 + VHOG + + + + + + The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG] + 2012-09-17 + VHOG:0000101 + VHOG + + DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007) + + + + + UMLS:C0022077 + ncithesaurus:Iris + + + + + irides + + + + + + irises + VHOG:0000101 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + the smooth stratified squamous epithelium that covers the outer surface of the cornea + Portion of tissue comprised of four to six layers of nonkeratinized, stratified squamous cells and represents approximately 60% of the thickness of the cornea.[TAO] + In Humans: It consists of several layers of cells. The cells of the deepest layer are columnar; then follow two or three layers of polyhedral cells, the majority of which are prickle cells similar to those found in the stratum mucosum of the cuticle. Lastly, there are three or four layers of squamous cells, with flattened nuclei + In zebrafish: nonpigmented, stratified squamous nonkeratinizing epithelial cells, attached to a thick basement membrane that is considered to be analogous to the Bowman's membrane in mammals + + + + BTO:0000287 + CALOHA:TS-0173 + EFO:0001917 + EHDAA2:0000319 + EMAPA:17162 + FMA:58263 + GAID:895 + MA:0001243 + MESH:D019573 + NCIT:C12928 + TAO:0002187 + UMLS:C0459875 + ZFA:0001683 + anterior corneal epithelium + cornea epithelial tissue + cornea epithelium + epithelial tissue of cornea + epithelium anterius (cornea) + epithelium anterius corneae + epithelium corneæ anterior layer + epithelium of cornea + external epithelium of cornea + uberon + anterior endothelium of cornea + e. anterius corneae + endothelium anterius corneae + endothelium camerae anterioris bulbi + endothelium corneale + epithelium posterius corneae + UBERON:0001772 + + + + + corneal epithelium + http://upload.wikimedia.org/wikipedia/commons/6/66/Gray871.png + + + + + + + + + + + ISBN:0781772214 + + + + + the smooth stratified squamous epithelium that covers the outer surface of the cornea + MESH:A09.371.060.217.325 + MGI:smb + MP:0006000 + + + + + Portion of tissue comprised of four to six layers of nonkeratinized, stratified squamous cells and represents approximately 60% of the thickness of the cornea.[TAO] + 2012-08-14 + TAO:0002187 + TAO + ZFIN:ZDB-PUB-061010-3 + + + + + UMLS:C0459875 + ncithesaurus:Corneal_Epithelium + + + + + cornea epithelial tissue + OBOL:automatic + + + + + cornea epithelium + OBOL:automatic + + + + + epithelial tissue of cornea + OBOL:automatic + + + + + epithelium anterius corneae + FMA:58263 + FMA:TA + + + + + + anterior endothelium of cornea + BTO:0000287 + + + + + e. anterius corneae + + + + + + + endothelium anterius corneae + BTO:0000287 + + + + + endothelium camerae anterioris bulbi + BTO:0000287 + + + + + endothelium corneale + BTO:0000287 + + + + + epithelium posterius corneae + BTO:0000287 + + + + + + + + + + + + + + + + + + + + + + + + + + + + Opaque fibrous outer layer of the eyeball[ZFA,Kardong,WP]. + The sclera, also known as the white part of the eye, is the opaque (usually white, though certain animals, such as horses and lizards, can have black sclera), fibrous, protective, outer layer of the eye containing collagen and elastic fiber. It is derived from the neural crest. In children, it is thinner and shows some of the underlying pigment, appearing slightly blue. In the elderly, however, fatty deposits on the sclera can make it appear slightly yellow. The sclera forms the posterior five sixths of the connective tissue coat of the globe. It is continuous with the dura mater and the cornea, and maintains the shape of the globe, offering resistance to internal and external forces, and provides an attachment for the extraocular muscle insertions. The sclera is perforated by plenty of nerves and vessels passing through the posterior scleral foramen, the hole that is formed by the optic nerve. At the optic disk the outer two-thirds of the sclera continues with the dura mater (outer coat of the brain) via the dural sheath of the optic nerve. The inner third joins with some choroidal tissue to form a plate (lamina cribrosa) across the optic nerve with perforations through which the optic fibers (fasciculi). The thickness of the sclera varies from 1mm at the posterior pole to 0.3 mm just behind the rectus muscle insertions. The sclera's blood vessels are mainly on the surface, and together with the conjunctiva (which lies on top) This is a thin layer covering the sclera. Along with the vessels of the conjunctiva, those of the sclera renders the inflamed eye bright red. [WP,unvetted][Wikipedia:Sclera]. + The tough, usually white, outer coat of the eyeball, covering all the posterior surface and continuous anteriorly with the cornea. [TFD][VHOG] + scleral + in fish, reptiles and monotremes the connective tissue of the sclera is skeletal + continuous with the dura mater and the cornea; The sclera forms the posterior five-sixths of the connective tissue coat of the globe. + Majority derives from NC that surrounds optic cup of neurectoderm; a small temporal portion develops from the mesoderm that contributes to striated extra-ocular muscles and vascular endothelia[Rada&Johnson]. + Seko et al demonstrate chondrogenic potential and identify this as connective tissue[DOI:10.1371/journal.pone.0003709]. + + + + AAO:0010354 + BTO:0001606 + EMAPA:19027 + EV:0100342 + FMA:58269 + GAID:911 + MA:0000280 + MESH:D012590 + NCIT:C12784 + OpenCyc:Mx4rv7yR55wpEbGdrcN5Y29ycA + UMLS:C0036410 + VHOG:0001274 + XAO:0000183 + ZFA:0005563 + uberon + scleral capsule + UBERON:0001773 + + + + Disease notes: implicated in rheumatoid arthritis. + sclera + http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg + + + + + + + + + + + FMA + + + + + + + + + + + ISBN:0781772214 + + + + + Opaque fibrous outer layer of the eyeball[ZFA,Kardong,WP]. + + ZFIN:ZDB-PUB-050701-15 + + + + + The sclera, also known as the white part of the eye, is the opaque (usually white, though certain animals, such as horses and lizards, can have black sclera), fibrous, protective, outer layer of the eye containing collagen and elastic fiber. It is derived from the neural crest. In children, it is thinner and shows some of the underlying pigment, appearing slightly blue. In the elderly, however, fatty deposits on the sclera can make it appear slightly yellow. The sclera forms the posterior five sixths of the connective tissue coat of the globe. It is continuous with the dura mater and the cornea, and maintains the shape of the globe, offering resistance to internal and external forces, and provides an attachment for the extraocular muscle insertions. The sclera is perforated by plenty of nerves and vessels passing through the posterior scleral foramen, the hole that is formed by the optic nerve. At the optic disk the outer two-thirds of the sclera continues with the dura mater (outer coat of the brain) via the dural sheath of the optic nerve. The inner third joins with some choroidal tissue to form a plate (lamina cribrosa) across the optic nerve with perforations through which the optic fibers (fasciculi). The thickness of the sclera varies from 1mm at the posterior pole to 0.3 mm just behind the rectus muscle insertions. The sclera's blood vessels are mainly on the surface, and together with the conjunctiva (which lies on top) This is a thin layer covering the sclera. Along with the vessels of the conjunctiva, those of the sclera renders the inflamed eye bright red. [WP,unvetted][Wikipedia:Sclera]. + + + + + + The tough, usually white, outer coat of the eyeball, covering all the posterior surface and continuous anteriorly with the cornea. [TFD][VHOG] + 2012-09-17 + VHOG:0001274 + VHOG + + + + + + + UMLS:C0036410 + ncithesaurus:Sclera + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + the thickened portion of the vascular tunic, which lies between the choroid and the iris, composed of ciliary muscle and ciliary processes + The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG] + + + + + AAO:0010341 + BTO:0000260 + CALOHA:TS-0694 + EMAPA:19065 + EV:0100346 + FMA:58295 + GAID:916 + MA:0000264 + MESH:D002924 + NCIT:C12345 + UMLS:C0008779 + VHOG:0000102 + XAO:0000186 + ocular ciliary body + uberon + anterior uvea + ciliary bodies + corpus ciliare + UBERON:0001775 + + + + ciliary body + http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg + + + + + + + + + + + ISBN:0781772214 + + + + + the thickened portion of the vascular tunic, which lies between the choroid and the iris, composed of ciliary muscle and ciliary processes + + ISBN:0-683-40008-8 + MP:0005099 + + + + + The eye of the adult lamprey is remarkably similar to our own, and it possesses numerous features (including the expression of opsin genes) that are very similar to those of the eyes of jawed vertebrates. The lamprey's camera-like eye has a lens, an iris and extra-ocular muscles (five of them, unlike the eyes of jawed vertebrates, which have six), although it lacks intra-ocular muscles. Its retina also has a structure very similar to that of the retinas of other vertebrates, with three nuclear layers comprised of the cell bodies of photoreceptors and bipolar, horizontal, amacrine and ganglion cells. The southern hemisphere lamprey, Geotria australis, possesses five morphological classes of retinal photoreceptor and five classes of opsin, each of which is closely related to the opsins of jawed vertebrates. Given these similarities, we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya.[well established][VHOG] + 2012-09-17 + VHOG:0000102 + VHOG + + DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007) + + + + + UMLS:C0008779 + ncithesaurus:Ciliary_Body + + + + + ciliary bodies + VHOG:0000102 + + + + + + corpus ciliare + + + + + + corpus ciliare + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + vascular layer containing connective tissue, of the eye lying between the retina and the sclera. The choroid provides oxygen and nourishment to the outer layers of the retina. Along with the ciliary body and iris, the choroid forms the uveal tract[WP]. + check choroid vs choroid layer; check ZFA/TAO placement - no homology assertion in VHOG. Note this is entirely in the posterior region of eyeball in ZFA + choroidal + MP treats posterior uvea and optic choroid as distinct + + + + BTO:0001829 + CALOHA:TS-2054 + EMAPA:19077 + EV:0100347 + FMA:58298 + GAID:913 + MA:0000263 + MESH:D002829 + NCIT:C12344 + TAO:0005229 + UMLS:C0008520 + VHOG:0001568 + ZFA:0005229 + choroid + choroid coat + choroidea + eye choroid + posterior uvea + uberon + chorioid + choroidea + optic choroid + UBERON:0001776 + + + + optic choroid + http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg + + + + + + + + + + + MA + + + + + + + + + + + + + + + + Wikipedia + + + + + + lexical + + + + + vascular layer containing connective tissue, of the eye lying between the retina and the sclera. The choroid provides oxygen and nourishment to the outer layers of the retina. Along with the ciliary body and iris, the choroid forms the uveal tract[WP]. + + + + + + MP treats posterior uvea and optic choroid as distinct + MP + + + + + UMLS:C0008520 + ncithesaurus:Choroid + + + + + choroid + MA:0000263 + + + + + choroid coat + + + + + + choroidea + + + + + + eye choroid + VHOG:0001568 + + + + + posterior uvea + + + + + + chorioid + BTO:0001829 + + + + + choroidea + + + + + + + optic choroid + ZFA:0005229 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A double layer covering the ciliary body that produces aqueous humor. + + + + BTO:0001770 + CALOHA:TS-0695 + EMAPA:35239 + FMA:58464 + MA:0001238 + NCIT:C32314 + UMLS:C0459736 + ciliary body epithelium + epithelium of ciliary body + ocular ciliary epithelium + uberon + UBERON:0001778 + ciliary epithelium + + + + + + FMA + + + + + + + + + + + MA + + + + + + + + + + + Wikipedia + + + + + A double layer covering the ciliary body that produces aqueous humor. + + + + + + UMLS:C0459736 + ncithesaurus:Ciliary_Epithelium + + + + + ciliary body epithelium + FMA:58464 + + + + + epithelium of ciliary body + FMA:58464 + + + + + + + + + + + + + + + + + + + + + Any of the layers that make up the retina[MP]. + MA does not treat internal/external limiting memranes as layers - these are classified as laminae. Here we follow other ontologies in grouping with other layers. MA also treats retinal pigment epithelium and neural retina epithelium as distinct from the layers. We follow ontologies such as FMA and ZFA in first dividing into pigmented and neural layers - these are also classified as layers, giving us over the usual 10 layers + + + AAO:0010353 + EMAPA:35742 + FMA:58617 + MA:0001319 + NCIT:C49328 + UMLS:C0459649 + XAO:0000266 + retina layer + retina neuronal layer + retinal layer + retinal neuronal layer + uberon + UBERON:0001781 + + + layer of retina + + + + + Any of the layers that make up the retina[MP]. + MP:0003727 + + + + + MA does not treat internal/external limiting memranes as layers - these are classified as laminae. Here we follow other ontologies in grouping with other layers. MA also treats retinal pigment epithelium and neural retina epithelium as distinct from the layers. We follow ontologies such as FMA and ZFA in first dividing into pigmented and neural layers - these are also classified as layers, giving us over the usual 10 layers + MA + + + + + UMLS:C0459649 + ncithesaurus:Retina_Layer + + + + + retina neuronal layer + MP:0006069 + + + + + retinal neuronal layer + MP:0006069 + + + + + + + + + + + + + + + + + + + + + + A thick watery refractive medium that fills the space between the lens and the cornea[WP]. + The fluid produced by the ciliary process in the eye and occupying the anterior and posterior chambers. It provides nourishment for the lens and cornea and maintains the ocular pressure, and hence the optical integrity of the eyeball. [TFD][VHOG] + (...) we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya (reference 1); Although the eye varies greatly in adaptative details among vertebrates, its basic structure is the same in all. The human eye is representative of the design typical for a tetrapod. (...) A watery aqueous humor fills the spaces in the eye in front of the lens (...) (reference 2).[well established][VHOG] + FMA says A+P chambers, and MA states A chamber. ZFA states A chamber and tha it is produced primarily by dorsal ciliary epithelial cells.To be investigated across taxa. + + + + EHDAA2:0000139 + EHDAA:10196 + EMAPA:18232 + ENVO:02000024 + FMA:58819 + GAID:890 + MA:0001236 + MESH:D001082 + NCIT:C13190 + OpenCyc:Mx4rvdGd-5wpEbGdrcN5Y29ycA + UMLS:C0003662 + VHOG:0000548 + ZFA:0005564 + aqueous humor + aqueous humour + humor aquosus + uberon + UBERON:0001796 + + + + aqueous humor of eyeball + http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg + + + + + + + + + + + FMA def states A and P + located_in in EHDAA2 + VHOG + + + + + A thick watery refractive medium that fills the space between the lens and the cornea[WP]. + + + + + + The fluid produced by the ciliary process in the eye and occupying the anterior and posterior chambers. It provides nourishment for the lens and cornea and maintains the ocular pressure, and hence the optical integrity of the eyeball. [TFD][VHOG] + 2012-09-17 + VHOG:0000548 + VHOG + + + + + + + (...) we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya (reference 1); Although the eye varies greatly in adaptative details among vertebrates, its basic structure is the same in all. The human eye is representative of the design typical for a tetrapod. (...) A watery aqueous humor fills the spaces in the eye in front of the lens (...) (reference 2).[well established][VHOG] + 2012-09-17 + VHOG:0000548 + VHOG + + DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007), ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.424 and p.426 and p.429 and Figure 12-24 + + + + + FMA says A+P chambers, and MA states A chamber. ZFA states A chamber and tha it is produced primarily by dorsal ciliary epithelial cells.To be investigated across taxa. + FMA + + + + + UMLS:C0003662 + ncithesaurus:Aqueous_Humor + + + + + aqueous humour + EHDAA2:0000139 + + + + + humor aquosus + FMA:58819 + FMA:TA + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive) + + + + EMAPA:36594 + FMA:58865 + MA:0002484 + MESH:D000869 + NCIT:C12668 + UMLS:C0003153 + ZFA:0005566 + anterior eye segment + anterior segment eye + anterior segment of eye + anterior segment of the eye + eye anterior segment + segmentum anterius (bulbus oculi) + uberon + segmentum anterius bulbi oculi + UBERON:0001801 + + + anterior segment of eyeball + http://upload.wikimedia.org/wikipedia/commons/b/ba/Cataract_in_human_eye.png + + + + + + + + + + + FMA + + + + + + + + + + + cjm + + + + + + lexical + + + + + any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive) + ISBN:0-683-40008-8 + MESH:A09.371.060 + MP:0005193 + + + + + UMLS:C0003153 + ncithesaurus:Anterior_Eye_Segment + + + + + anterior segment eye + ZFA:0005566 + + + + + segmentum anterius bulbi oculi + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + any of the parts of the eye that lie in back of, or dorsal to, the lens (but not inclusive) + + + + EMAPA:36595 + FMA:58868 + MA:0002485 + NCIT:C12906 + UMLS:C0278450 + ZFA:0005567 + eye posterior segment + posterior eye segment + posterior segment eye + posterior segment of eye + posterior segment of the eye + segmentum posterius (bulbus oculi) + uberon + segmentum posterius bulbi oculi + UBERON:0001802 + + + posterior segment of eyeball + http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg + + + + + + + + + + + FMA + + + + + + + + + + + cjm + + + + + + lexical + + + + + any of the parts of the eye that lie in back of, or dorsal to, the lens (but not inclusive) + ISBN:0-683-40008-8 + MP:0005195 + + + + + UMLS:C0278450 + ncithesaurus:Posterior_Eye_Segment + + + + + posterior segment eye + ZFA:0005567 + + + + + segmentum posterius bulbi oculi + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A layer of epithelial cells that is part of the eye. + this class is the superclass of the anterior epithelium and equatorial epithlium, although the term 'lens epithelium' may refer specifically to the former + + + BTO:0001873 + CALOHA:TS-0543 + EMAPA:32871 + FMA:58871 + MA:0001301 + TAO:0001326 + XAO:0004094 + ZFA:0001326 + epithelial tissue of eye lens + epithelial tissue of lens + epithelium lentis + epithelium of eye lens + eye lens epithelial tissue + eye lens epithelium + lens epithelial tissue + lens epithelium + uberon + UBERON:0001803 + + + epithelium of lens + + + + + A layer of epithelial cells that is part of the eye. + + + + + + epithelial tissue of eye lens + OBOL:automatic + + + + + epithelial tissue of lens + OBOL:automatic + + + + + epithelium lentis + FMA:58871 + FMA:TA + + + + + + epithelium of eye lens + OBOL:automatic + + + + + eye lens epithelial tissue + OBOL:automatic + + + + + eye lens epithelium + OBOL:automatic + + + + + lens epithelial tissue + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + the elastic, clear, membrane-like structure, that is outer most layer of the lens + The transparent membrane which surrounds the lens of the eye. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG] + (...) we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya (reference 1); Although the eye varies greatly in adaptative details among vertebrates, its basic structure is the same in all. The human eye is representative of the design typical for a tetrapod. (...) A watery aqueous humor fills the spaces in the eye in front of the lens (...) (reference 2).[well established][VHOG] + synthesized by the lens epithelium and its main components are Type IV collagen and sulfated glycosaminoglycans (GAGs). [Wikipedia:Capsule_of_lens + FMA classifies this is a capsule and hence an organ part. In contrast we classify this as acellular + + + + EHDAA2:0000977 + EMAPA:18237 + FMA:58881 + MA:0001300 + NCIT:C32975 + UMLS:C0229232 + VHOG:0000550 + ZFA:0005574 + capsula lentis + lens capsule + uberon + UBERON:0001804 + + + + capsule of lens + http://upload.wikimedia.org/wikipedia/commons/5/55/Gray883.png + + + + + + + + + + + EHDAA2 + + + + + the elastic, clear, membrane-like structure, that is outer most layer of the lens + + MGI:smb + MP:0003236 + + + + + The transparent membrane which surrounds the lens of the eye. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG] + 2012-09-17 + VHOG:0000550 + VHOG + + + + + + (...) we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya (reference 1); Although the eye varies greatly in adaptative details among vertebrates, its basic structure is the same in all. The human eye is representative of the design typical for a tetrapod. (...) A watery aqueous humor fills the spaces in the eye in front of the lens (...) (reference 2).[well established][VHOG] + 2012-09-17 + VHOG:0000550 + VHOG + + DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007), ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.424 and p.426 and p.429 and Figure 12-24 + + + + + FMA classifies this is a capsule and hence an organ part. In contrast we classify this as acellular + FMA + + + + + UMLS:C0229232 + ncithesaurus:Lens_Capsule + + + + + capsula lentis + + + + + + + + + + + + + + + + + + + + + + + + + + + + One of the two fleshy folds which surround the opening of the mouth. + Surface structure that is one of the two fleshy folds surrounding the opening of the mouth.[TAO] + labial + + + + BTO:0001647 + CALOHA:TS-0558 + EMAPA:32839 + FMA:59816 + GAID:76 + MA:0000343 + MESH:D008046 + NCIT:C12220 + OpenCyc:Mx4rvVi4U5wpEbGdrcN5Y29ycA + TAO:0007006 + UMLS:C0023759 + VHOG:0000677 + ZFA:0007006 + galen:Lip + uberon + labia oris + lips + UBERON:0001833 + + + + lip + http://upload.wikimedia.org/wikipedia/commons/9/90/Lips.JPG + http://upload.wikimedia.org/wikipedia/commons/9/99/Mouth.jpg + + + + + + ZFA + + + + + + + + + + + BTO + FMA-implicit + VHOG + ZFA + + + + + + + + + + + cjm + + + + + One of the two fleshy folds which surround the opening of the mouth. + + + + + + + Surface structure that is one of the two fleshy folds surrounding the opening of the mouth.[TAO] + 2012-08-14 + TAO:0007006 + TAO + + ZFIN:curator + + + + + UMLS:C0023759 + ncithesaurus:Lip + + + + + labia oris + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Lip that covers the lower portion of the mouth.[TAO]. + Lip that covers the lower portion of the mouth.[TAO] + UBERON:0003392 + + + + EHDAA2:0001020 + EMAPA:17909 + FMA:59818 + MA:0000921 + NCIT:C94572 + OpenCyc:Mx4rv842UpwpEbGdrcN5Y29ycA + TAO:0002060 + UMLS:C0458583 + ZFA:0005225 + lower jaw lip + uberon + labium inferius oris + UBERON:0001835 + + + + lower lip + http://upload.wikimedia.org/wikipedia/commons/9/99/Mouth.jpg + + + + + Lip that covers the lower portion of the mouth.[TAO]. + + TAO:0002060 + + + + + Lip that covers the lower portion of the mouth.[TAO] + 2012-08-14 + TAO:0002060 + TAO + TAO:wd + + + + + UMLS:C0458583 + ncithesaurus:Lower_Lip + + + + + lower jaw lip + + + + + + labium inferius oris + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + One of two bilateral, largely symmetrical organ subdivisions within the telencephalon which contain the cerebral cortex and cerebral white matter.[FMA] + Part of the telencephalon consisting of either of the two smooth, elongated halves of the cerebrum.[AAO] + The presence of paired evaginated hemispheres and olfactory bulbs in both agnathan and gnathostome radiations suggests that such hemispheres were also present in the common ancestor.[well established][VHOG] + + + + + + AAO:0010480 + BAMS:HEM + BIRNLEX:1042 + BTO:0000231 + CALOHA:TS-2007 + DMBA:15739 + EFO:0002521 + EMAPA:16653 + FMA:61817 + MA:0000133 + MBA:403 + NCIT:C12351 + OpenCyc:Mx4rvigx5ZwpEbGdrcN5Y29ycA + UMLS:C0228174 + UMLS:C0242202 + VHOG:0001639 + galen:CerebralHemisphere + http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=241 + uberon + cerebrum + hemisphere + hemispheric regions + hemispherium cerebri + medial amygdalar nucleus + nucleus amygdaloideus medialis + nucleus medialis amygdalae + UBERON:0001869 + + + + cerebral hemisphere + http://upload.wikimedia.org/wikipedia/commons/9/92/Hemispheres.png + + + + + + + + + + + FMA-abduced-lr + + + + + One of two bilateral, largely symmetrical organ subdivisions within the telencephalon which contain the cerebral cortex and cerebral white matter.[FMA] + + FMA:61817 + + + + + Part of the telencephalon consisting of either of the two smooth, elongated halves of the cerebrum.[AAO] + 2012-06-20 + AAO:0010480 + AAO + AAO:BJB + + + + + The presence of paired evaginated hemispheres and olfactory bulbs in both agnathan and gnathostome radiations suggests that such hemispheres were also present in the common ancestor.[well established][VHOG] + 2012-09-17 + VHOG:0001639 + VHOG + + DOI:10.1146/annurev.ne.04.030181.001505 Northcutt RG, Evolution of the telencephalon in nonmammals. Ann. Rev. Neurosci. (1981) + + + + + UMLS:C0228174 + ncithesaurus:Cerebral_Hemisphere + + + + + UMLS:C0242202 + BIRNLEX:1042 + + + + + http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=241 + BIRNLEX:1042 + + + + + cerebrum + + MA:0000133 + VHOG:0001639 + + + + + hemisphere + VHOG:0001639 + + + + + hemispheric regions + BAMS:HEM + + + + + hemispherium cerebri + + + + + + + medial amygdalar nucleus + NeuroNames:241 + + + + + nucleus amygdaloideus medialis + NeuroNames:241 + + + + + + nucleus medialis amygdalae + NeuroNames:241 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The most anterior region the brain including both the telencephalon and diencephalon. + Most anterior of the three regions of the brain consisting of the telencephalon and diencephalon.[AAO] + The most anterior region the brain including both the telencephalon and diencephalon. Kimmel et al, 1995.[TAO] + relationship loss: develops_from forebrain neural tube (TAO:0007041)[TAO] + In craniate embryos, neural expression of Distal-less-related genes is exclusively in the forebrain (...). Because the major neural expression domain of amphioxus AmphiDll is in the anterior three-fourths of the cerebral vesicle, we suggest that this region of the neural tube is homologous to parts of the craniate forebrain. This conclusion is strongly supported by three-dimensional, computer-assisted reconstruction of the neural tube of amphioxus based on serial transmission electron microscopy. At the neuroanatomical level, a number of detailed homologies are indicated between the anterior three-fourths of the amphioxus cerebral vesicle and the diencephalic region of the craniate forebrain. If one assumes that the amphioxus condition fairly represents the nervous system of the proximate ancestor of the craniates, one can suggest that they evolved from a creature that had the beginnings of a forebrain.[well established][VHOG] + prosencephalic + FB + + + + + AAO:0010147 + BAMS:FB + BAMS:Forebrain + BIRNLEX:1509 + BTO:0000478 + CALOHA:TS-0380 + DHBA:10156 + DMBA:15566 + EFO:0000909 + EHDAA2:0000556 + EHDAA:3470 + EMAPA:16895 + FMA:61992 + MA:0000170 + MAT:0000105 + MESH:D016548 + MIAA:0000105 + NCIT:C40185 + TAO:0000109 + UMLS:C0085140 + VHOG:0000383 + XAO:0000011 + ZFA:0000109 + http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=27 + uberon + prosencephalon + UBERON:0001890 + + + + + forebrain + http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg + + + + + + + + + + + definitional + + + + + The most anterior region the brain including both the telencephalon and diencephalon. + + ZFIN:ZDB-PUB-961014-576 + + + + + Most anterior of the three regions of the brain consisting of the telencephalon and diencephalon.[AAO] + 2012-06-20 + AAO:0010147 + AAO + AAO:BJB + + + + + The most anterior region the brain including both the telencephalon and diencephalon. Kimmel et al, 1995.[TAO] + 2012-08-14 + TAO:0000109 + TAO + ZFIN:curator + + + + + relationship loss: develops_from forebrain neural tube (TAO:0007041)[TAO] + 2012-08-14 + TAO:0000109 + TAO + + + + + In craniate embryos, neural expression of Distal-less-related genes is exclusively in the forebrain (...). Because the major neural expression domain of amphioxus AmphiDll is in the anterior three-fourths of the cerebral vesicle, we suggest that this region of the neural tube is homologous to parts of the craniate forebrain. This conclusion is strongly supported by three-dimensional, computer-assisted reconstruction of the neural tube of amphioxus based on serial transmission electron microscopy. At the neuroanatomical level, a number of detailed homologies are indicated between the anterior three-fourths of the amphioxus cerebral vesicle and the diencephalic region of the craniate forebrain. If one assumes that the amphioxus condition fairly represents the nervous system of the proximate ancestor of the craniates, one can suggest that they evolved from a creature that had the beginnings of a forebrain.[well established][VHOG] + 2012-09-17 + VHOG:0000383 + VHOG + + PMID:8787764 Holland ND, Panganiban G, Henyey EL, Holland LZ, Sequence and developmental expression of AmphiDll, an amphioxus Distal-less gene transcribed in the ectoderm, epidermis and nervous system: insights into evolution of craniate forebrain and neural crest. Development (1996) + + + + + FB + BIRNLEX:1509 + NIFSTD:NeuroNames_abbrevSource + + + + + + UMLS:C0085140 + BIRNLEX:1509 + + + + + UMLS:C0085140 + ncithesaurus:Fore-Brain + + + + + http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=27 + BIRNLEX:1509 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)[GO]. + developmental relationships need revised + Middle part of the brain composed of the optic tectum and penducular region.[AAO] + The brain region between the forebrain anteriorly and the hindbrain posteriorly, including the tectum dorsally and the midbrain tegmentum ventrally. Kimmel et al, 1995.[TAO] + Fine structural, computerized three-dimensional (3D) mapping of cell connectivity in the amphioxus nervous system and comparative molecular genetic studies of amphioxus and tunicates have provided recent insights into the phylogenetic origin of the vertebrate nervous system. The results suggest that several of the genetic mechanisms for establishing and patterning the vertebrate nervous system already operated in the ancestral chordate and that the nerve cord of the proximate invertebrate ancestor of the vertebrates included a diencephalon, midbrain, hindbrain, and spinal cord.[well established][VHOG] + mesencephalic + part of brainstem in ABA - we reject this in favor of ISBN:0471888893 which has an implicit overlaps relationships + MB + + + + + AAO:0010149 + BAMS:MES + BIRNLEX:1667 + BM:MB + BTO:0000138 + CALOHA:TS-0630 + DHBA:10648 + DMBA:16649 + EFO:0000919 + EHDAA2:0001162 + EHDAA:3694 + EMAPA:16974 + EV:0100242 + FMA:61993 + HBA:9001 + MA:0000207 + MAT:0000106 + MBA:313 + MESH:D008636 + MIAA:0000106 + NCIT:C12510 + OpenCyc:Mx4rvsBUqpwpEbGdrcN5Y29ycA + RETIRED_EHDAA2:0001104 + TAO:0000128 + UMLS:C0025462 + VHOG:0000069 + XAO:0000014 + ZFA:0000128 + http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=462 + uberon + mesencephalon + UBERON:0001891 + + + + + midbrain + http://upload.wikimedia.org/wikipedia/commons/f/f9/Human_brain_inferior_view_description.JPG + + + + + + + + + + + definitional + + + + + + + + + + + Bgee:AN + + + + + The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)[GO]. + GO:0030901 + + + + + Middle part of the brain composed of the optic tectum and penducular region.[AAO] + 2012-06-20 + AAO:0010149 + AAO + AAO:BJB + + + + + The brain region between the forebrain anteriorly and the hindbrain posteriorly, including the tectum dorsally and the midbrain tegmentum ventrally. Kimmel et al, 1995.[TAO] + 2012-08-14 + TAO:0000128 + TAO + ZFIN:curator + + + + + Fine structural, computerized three-dimensional (3D) mapping of cell connectivity in the amphioxus nervous system and comparative molecular genetic studies of amphioxus and tunicates have provided recent insights into the phylogenetic origin of the vertebrate nervous system. The results suggest that several of the genetic mechanisms for establishing and patterning the vertebrate nervous system already operated in the ancestral chordate and that the nerve cord of the proximate invertebrate ancestor of the vertebrates included a diencephalon, midbrain, hindbrain, and spinal cord.[well established][VHOG] + 2012-09-17 + VHOG:0000069 + VHOG + + DOI:10.1016/S0959-4388(99)00003-3 Holland LZ and Holland ND, Chordate origins of the vertebrate central nervous system. Current Opinion in Neurobiology (1999) + + + + + part of brainstem in ABA - we reject this in favor of ISBN:0471888893 which has an implicit overlaps relationships + ABA + + + + + MB + BIRNLEX:1667 + NIFSTD:NeuroNames_abbrevSource + + + + + + UMLS:C0025462 + BIRNLEX:1667 + + + + + UMLS:C0025462 + ncithesaurus:Mesencephalon + + + + + http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=462 + BIRNLEX:1667 + + + + + mesencephalon + + + + + + + + + + + + + + + + + + + + + + + + + + + + A segment of the developing hindbrain[ZFA]. In the vertebrate embryo, a rhombomere is a transiently divided segment of the developing neural tube, within the hindbrain region (a neuromere) in the area that will eventually become the rhombencephalon. The rhombomeres appear as a series of slightly constricted swellings in the neural tube, caudal to the cephalic flexure.[WP]. + A segment of the developing hindbrain. Kimmel et al, 1995.[TAO] + Rhombomeric segmentation is found in all living vertebrates and is of fundamental importance to the development of the vertebrate head.[well established][VHOG] + In human embryonic development, the rhombomeres are present by day 29 + DHBA divides this into A(1-3),B(4),C(5-7) and D(8) + hindbrain segment + segment of hindbrain + + DHBA:12664 + EFO:0003617 + EMAPA:16148 + FMA:295666 + MAT:0000272 + MIAA:0000272 + RETIRED_EHDAA2:0000669 + TAO:0001064 + VHOG:0000672 + XAO:0004079 + ZFA:0001064 + hindbrain neuromere + hindbrain neuromeres + rhombomere + uberon + future rhombencephalon + rhombomeres + UBERON:0001892 + + + + + rhombomere + + + + + A segment of the developing hindbrain[ZFA]. In the vertebrate embryo, a rhombomere is a transiently divided segment of the developing neural tube, within the hindbrain region (a neuromere) in the area that will eventually become the rhombencephalon. The rhombomeres appear as a series of slightly constricted swellings in the neural tube, caudal to the cephalic flexure.[WP]. + + ZFIN:curator + + + + + A segment of the developing hindbrain. Kimmel et al, 1995.[TAO] + 2012-08-14 + TAO:0001064 + TAO + ZFIN:curator + + + + + Rhombomeric segmentation is found in all living vertebrates and is of fundamental importance to the development of the vertebrate head.[well established][VHOG] + 2012-09-17 + VHOG:0000672 + VHOG + + DOI:10.1006/dbio.2002.0831 Mazet F, Shimeld SM, The Evolution of Chordate Neural Segmentation. Developmental Biology (2002) + + + + + hindbrain segment + ZFA:0001064 + + + + + segment of hindbrain + ZFA:0001064 + + + + + hindbrain neuromeres + DHBA:HNM + + + + + + future rhombencephalon + MIAA:0000272 + + + + + rhombomeres + VHOG:0000672 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Part of the forebrain consisting of paired olfactory bulbs and cerebral hemispheres. + Organ component of neuraxis that has as its parts the cerebral cortex, cerebral white matter, basal ganglia, septum and fornix, as well as subcortical gray and white matter structures[FMA:62000]. + Part of the forebrain consisting of paired olfactory bulbs and cerebral hemispheres.[AAO] + The anterior and dorsal forebrain neuromere, includes the olfactory bulb. Kimmel et al, 1995.[TAO] + relationship loss: develops_from presumptive telencephalon (TAO:0000571)[TAO] + From an evolutionary standpoint, the telencephalon is the most recent brain structure: the amphioxus does not have this structure as a morphological entity. Overt telencephalon is present in the hagfish and lamprey to receive numerous input fibers from various parts of the CNS, similar to gnathostomes.[well established][VHOG] + cerebral + telenencephalic + In mammals the cortex covers almost the whole of the cerebral hemispheres. + In ray-finned fishes and most pronounced in teleosts the roof plate of the embryonic telencephalon extends laterally with the effect that the paired alar plates forming the hemispheric walls roll out lateroventrally in a process called eversion. This is unlike the development in other vertebrate groups. [ZFA:0000079, ISBN:3764351209] + In ray-finned fishes the inner surfaces of the lateral and ventral regions of the cerebrum bulge up into the ventricles. + In the amniotes, the cerebrum becomes increasingly large and complex. In reptiles, the paleopallium is much larger than in amphibians, and its growth has pushed the basal nuclei into the central regions of the cerebrum. + In the most primitive living vertebrates, the hagfishes and lampreys, the cerebrum is a relatively simple structure receiving nerve impulses from the olfactory bulb. + The cerebrum of birds has evolved along different lines to that of mammals, although they are similarly enlarged, by comparison with reptiles. However, this enlargement is largely due to the basal ganglia, with the other areas remaining relatively primitive in structure. + dolphins are the only species (other than humans) to have cerebra accounting for as much as 2 percent of their body weight. + supratentorial region + + + + + AAO:0010479 + BAMS:CB + BAMS:CH + BAMS:IV + BAMS:Tel + BIRNLEX:1115 + BM:Tel + BTO:0000239 + CALOHA:TS-1018 + DHBA:10158 + EFO:0000912 + EHDAA2:0001982 + EMAPA:16910 + EV:0100165 + FMA:62000 + GAID:621 + HBA:4007 + MA:0000183 + MAT:0000421 + MBA:567 + MESH:D013687 + MIAA:0000421 + PBA:128011350 + TAO:0000079 + UMLS:C0039452 + VHOG:0000283 + XAO:0000012 + ZFA:0000079 + http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=31 + cerebrum + endbrain + uberon + UBERON:0001893 + + + + + telencephalon + + + + + + + + + + + Bgee:AN + + + + + Part of the forebrain consisting of paired olfactory bulbs and cerebral hemispheres. + AAO:0010479 + XAO:0000012 + + + + + Organ component of neuraxis that has as its parts the cerebral cortex, cerebral white matter, basal ganglia, septum and fornix, as well as subcortical gray and white matter structures[FMA:62000]. + FMA:62000 + + + + + Part of the forebrain consisting of paired olfactory bulbs and cerebral hemispheres.[AAO] + 2012-06-20 + AAO:0010479 + AAO + AAO:BJB + + + + + The anterior and dorsal forebrain neuromere, includes the olfactory bulb. Kimmel et al, 1995.[TAO] + 2012-08-14 + TAO:0000079 + TAO + ZFIN:curator + + + + + relationship loss: develops_from presumptive telencephalon (TAO:0000571)[TAO] + 2012-08-14 + TAO:0000079 + TAO + + + + + From an evolutionary standpoint, the telencephalon is the most recent brain structure: the amphioxus does not have this structure as a morphological entity. Overt telencephalon is present in the hagfish and lamprey to receive numerous input fibers from various parts of the CNS, similar to gnathostomes.[well established][VHOG] + 2012-09-17 + VHOG:0000283 + VHOG + + DOI:10.1016/j.ydbio.2005.02.008 Murakami Y, Uchida K, Rijli FM and Kuratani S, Evolution of the brain developmental plan: Insights from agnathans. Developmental Biology (2005) + + + + + In mammals the cortex covers almost the whole of the cerebral hemispheres. + + + + + + In ray-finned fishes the inner surfaces of the lateral and ventral regions of the cerebrum bulge up into the ventricles. + + + + + + In the amniotes, the cerebrum becomes increasingly large and complex. In reptiles, the paleopallium is much larger than in amphibians, and its growth has pushed the basal nuclei into the central regions of the cerebrum. + + + + + + In the most primitive living vertebrates, the hagfishes and lampreys, the cerebrum is a relatively simple structure receiving nerve impulses from the olfactory bulb. + + + + + + The cerebrum of birds has evolved along different lines to that of mammals, although they are similarly enlarged, by comparison with reptiles. However, this enlargement is largely due to the basal ganglia, with the other areas remaining relatively primitive in structure. + + + + + + dolphins are the only species (other than humans) to have cerebra accounting for as much as 2 percent of their body weight. + + + + + + supratentorial region + + + + + + UMLS:C0039452 + BIRNLEX:1115 + + + + + http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=31 + BIRNLEX:1115 + + + + + cerebrum + + + BTO:0000239 + EMAPA:16910 + FMA:62000 + + + + + endbrain + + Swanson:2004 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The division of the forebrain that develops from the foremost primary cerebral vesicle. + + The more posterior and ventral of two forebrain neuromeres, the other being the telencephalon; major derivatives are the eye cups, the brain pretectal region, the thalamus, hypothalamus, and epithalamus (including the habenula and epiphysis). Kimmel et al, 1995.[TAO] + Unpaired part of the forebrain comprised of three major parts; the epithalamus, thalamus, and hypothalamus.[AAO] + Fine structural, computerized three-dimensional (3D) mapping of cell connectivity in the amphioxus nervous system and comparative molecular genetic studies of amphioxus and tunicates have provided recent insights into the phylogenetic origin of the vertebrate nervous system. The results suggest that several of the genetic mechanisms for establishing and patterning the vertebrate nervous system already operated in the ancestral chordate and that the nerve cord of the proximate invertebrate ancestor of the vertebrates included a diencephalon, midbrain, hindbrain, and spinal cord.[well established][VHOG] + diencephalic + in ABA, this is part of the brain stem + DiE + + + + + AAO:0010481 + BAMS:DI + BAMS:Di + BAMS:DiE + BAMS:IB + BAMS:Zh. + BIRNLEX:1503 + BM:Die + BTO:0000342 + CALOHA:TS-0199 + DHBA:10389 + DMBA:16308 + EFO:0000911 + EHDAA2:0000385 + EHDAA:1969 + EHDAA:2645 + EHDAA:3472 + EMAPA:16896 + EV:0100194 + FMA:62001 + GAID:618 + HBA:4391 + MA:0000171 + MAT:0000420 + MBA:1129 + MESH:A08.186.211.730.385 + MIAA:0000420 + NCIT:C12456 + OpenCyc:Mx4rwC-V0JwpEbGdrcN5Y29ycA + PBA:128013010 + TAO:0000101 + UMLS:C0012144 + VHOG:0000318 + XAO:0000013 + ZFA:0000101 + http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=288 + between brain + interbrain + mature diencephalon + thalamencephalon + uberon + betweenbrain + diencephalon + UBERON:0001894 + + + + + diencephalon + http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg + + + + + + + + + + + definitional + + + + + + + + + + + definitional + + + + + The division of the forebrain that develops from the foremost primary cerebral vesicle. + + + + + + + not well differentiated from the cerebrum. (Ariens, p. 868) + + + + + + The more posterior and ventral of two forebrain neuromeres, the other being the telencephalon; major derivatives are the eye cups, the brain pretectal region, the thalamus, hypothalamus, and epithalamus (including the habenula and epiphysis). Kimmel et al, 1995.[TAO] + 2012-08-14 + TAO:0000101 + TAO + ZFIN:curator + + + + + Unpaired part of the forebrain comprised of three major parts; the epithalamus, thalamus, and hypothalamus.[AAO] + 2012-06-20 + AAO:0010481 + AAO + AAO:BJB + + + + + Fine structural, computerized three-dimensional (3D) mapping of cell connectivity in the amphioxus nervous system and comparative molecular genetic studies of amphioxus and tunicates have provided recent insights into the phylogenetic origin of the vertebrate nervous system. The results suggest that several of the genetic mechanisms for establishing and patterning the vertebrate nervous system already operated in the ancestral chordate and that the nerve cord of the proximate invertebrate ancestor of the vertebrates included a diencephalon, midbrain, hindbrain, and spinal cord.[well established][VHOG] + 2012-09-17 + VHOG:0000318 + VHOG + + DOI:10.1016/S0959-4388(99)00003-3 Holland LZ and Holland ND, Chordate origins of the vertebrate central nervous system. Current Opinion in Neurobiology (1999) + + + + + in ABA, this is part of the brain stem + ABA + + + + + DiE + BIRNLEX:1503 + NIFSTD:NeuroNames_abbrevSource + + + + + + UMLS:C0012144 + BIRNLEX:1503 + + + + + UMLS:C0012144 + ncithesaurus:Diencephalon + + + + + http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=288 + BIRNLEX:1503 + + + + + interbrain + Swanson:2004 + + + + + mature diencephalon + FMA:62001 + + + + + thalamencephalon + MGI:anna + + + + + betweenbrain + BTO:0000342 + + + + + diencephalon + + + + + + + + + + + + + + + + + + + + + + + + + Organ component of neuraxis that has as its parts the medullary reticular formation, inferior olivary complex and cochlear nuclear complex, among other structures[FMA]. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate[GO]. + Posterior portion of the hindbrain which controls respiration, heartbeat, digestion, and swallowing as well as some locomotor responses.[AAO] + The posterior region of the brain that is continuous with the spinal cord. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-17, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG] + Classical anatomical studies subdivided the vertebrate rhombencephalon into pons and medulla oblongata. (...) The medulla oblongata appears therefore as a tagma, that is, a group of segmental units (pseudorhombomeres, in this case) sharing some morphological and molecular characteristics, and in some aspects different from the segmental units present in adjoining brain regions, pons and spinal cord.[well established][VHOG] + bulb + medulla + + + + + + AAO:0010486 + BAMS:MY + BAMS:Md + BIRNLEX:957 + BM:Me + BTO:0000041 + CALOHA:TS-0607 + DMBA:17352 + EFO:0000924 + EHDAA2:0001088 + EHDAA:7588 + EMAPA:17550 + EV:0100275 + FMA:62004 + GAID:590 + MA:0000206 + MAT:0000111 + MAT:0000367 + MBA:354 + MESH:D008526 + MIAA:0000111 + NCIT:C12442 + OpenCyc:Mx4rvVjxSJwpEbGdrcN5Y29ycA + OpenCyc:Mx4rwCqnXJwpEbGdrcN5Y29ycA + TAO:0000545 + UMLS:C0025148 + UMLS:C1269575 + VHOG:0000181 + XAO:0003100 + ZFA:0000545 + http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=698 + bulbus + uberon + medulla oblonzata + metepencephalon + UBERON:0001896 + + + + + medulla oblongata + http://upload.wikimedia.org/wikipedia/commons/6/6b/Illu_pituitary_pineal_glands.jpg + + + + + Organ component of neuraxis that has as its parts the medullary reticular formation, inferior olivary complex and cochlear nuclear complex, among other structures[FMA]. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate[GO]. + + FMA:62004 + GO:0021550 + + + + + Posterior portion of the hindbrain which controls respiration, heartbeat, digestion, and swallowing as well as some locomotor responses.[AAO] + 2012-06-20 + AAO:0010486 + AAO + AAO:BJB + + + + + The posterior region of the brain that is continuous with the spinal cord. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-17, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG] + 2012-09-17 + VHOG:0000181 + VHOG + + + + + + Classical anatomical studies subdivided the vertebrate rhombencephalon into pons and medulla oblongata. (...) The medulla oblongata appears therefore as a tagma, that is, a group of segmental units (pseudorhombomeres, in this case) sharing some morphological and molecular characteristics, and in some aspects different from the segmental units present in adjoining brain regions, pons and spinal cord.[well established][VHOG] + 2012-09-17 + VHOG:0000181 + VHOG + + DOI:10.1016/j.ydbio.2008.08.017 Marin F, Aroca P, Puelles L, Hox gene colinear expression in the avian medulla oblongata is correlated with pseudorhombomeric domains. Developmental Biology (2008) + + + + + medulla + ABA:MY + + + + + UMLS:C0025148 + BIRNLEX:957 + + + + + UMLS:C0025148 + ncithesaurus:Medulla_Oblongata + + + + + UMLS:C1269575 + BIRNLEX:957 + + + + + http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=698 + BIRNLEX:957 + + + + + bulbus + FMA:62004 + FMA:TA + + + + + + medulla oblonzata + + + + + + + metepencephalon + FMA:62004 + + + + + + + + + + + + + + + + + + + + + + + + + + An endothelium that is part of a capillary [Automatically generated definition]. + + BTO:0004954 + CALOHA:TS-0112 + EMAPA:36292 + FMA:62114 + MA:0000711 + NCIT:C49215 + UMLS:C0006904 + blood capillary endothelium + capillary endothelium + capillary vessel endothelium + endothelium of blood capillary + endothelium of capillary vessel + uberon + UBERON:0001915 + endothelium of capillary + + + + + An endothelium that is part of a capillary [Automatically generated definition]. + OBOL:automatic + + + + + UMLS:C0006904 + ncithesaurus:Capillary_Endothelium + + + + + blood capillary endothelium + OBOL:automatic + + + + + capillary vessel endothelium + OBOL:automatic + + + + + endothelium of blood capillary + OBOL:automatic + + + + + endothelium of capillary vessel + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + An endothelium that is part of an arteriole [Automatically generated definition]. + + EMAPA:36286 + FMA:62115 + MA:0000705 + NCIT:C49192 + UMLS:C1179024 + arteriole endothelium + uberon + UBERON:0001916 + endothelium of arteriole + + + + + An endothelium that is part of an arteriole [Automatically generated definition]. + OBOL:automatic + + + + + UMLS:C1179024 + ncithesaurus:Arteriole_Endothelium + + + + + + + + + + + + + + + + + + + + + + + + + + + + An endothelium that is part of an artery [Automatically generated definition]. + The endothelium is the thin layer of cells that lines the interior surface of blood vessels, forming an interface between circulating blood in the lumen and the rest of the vessel wall.[AAO] + Vertebrates and a very few invertebrates such as squids have evolved a secondary epithelium, the endothelium, that lines their blood vessels.[well established][VHOG] + + AAO:0011013 + BTO:0004757 + EMAPA:35148 + FMA:62116 + MA:0000707 + NCIT:C49194 + UMLS:C1179025 + VHOG:0001215 + XAO:0000357 + arterial endothelium + artery endothelium + uberon + UBERON:0001917 + endothelium of artery + + + + + An endothelium that is part of an artery [Automatically generated definition]. + OBOL:automatic + + + + + The endothelium is the thin layer of cells that lines the interior surface of blood vessels, forming an interface between circulating blood in the lumen and the rest of the vessel wall.[AAO] + 2012-06-20 + AAO:0011013 + AAO + XAO:curator + + + + + Vertebrates and a very few invertebrates such as squids have evolved a secondary epithelium, the endothelium, that lines their blood vessels.[well established][VHOG] + 2012-09-17 + VHOG:0001215 + VHOG + + ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.207 + + + + + UMLS:C1179025 + ncithesaurus:Artery_Endothelium + + + + + + + + + + + + + + + + + + + + + + + + + + + An endothelium that is part of a venule [Automatically generated definition]. + + EMAPA:36290 + FMA:62117 + MA:0000716 + NCIT:C49319 + UMLS:C1179026 + venule endothelium + uberon + UBERON:0001918 + endothelium of venule + + + + + An endothelium that is part of a venule [Automatically generated definition]. + OBOL:automatic + + + + + UMLS:C1179026 + ncithesaurus:Venule_Endothelium + + + + + + + + + + + + + + + + + + + + + + + + + + + An endothelium that is part of a vein [Automatically generated definition]. + Vertebrates and a very few invertebrates such as squids have evolved a secondary epithelium, the endothelium, that lines their blood vessels.[well established][VHOG] + + AAO:0011110 + BTO:0004756 + EMAPA:36288 + FMA:62118 + MA:0000712 + NCIT:C49317 + UMLS:C1179027 + VHOG:0001216 + XAO:0000358 + vein endothelium + venous endothelium + uberon + veinous endothelium + UBERON:0001919 + endothelium of vein + + + + + An endothelium that is part of a vein [Automatically generated definition]. + OBOL:automatic + + + + + Vertebrates and a very few invertebrates such as squids have evolved a secondary epithelium, the endothelium, that lines their blood vessels.[well established][VHOG] + 2012-09-17 + VHOG:0001216 + VHOG + + ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.207 + + + + + UMLS:C1179027 + ncithesaurus:Vein_Endothelium + + + + + veinous endothelium + VHOG:0001216 + + + + + + + + + + + + + + + + + + + + + + + + + + + Ventral part of the midbrain, separated from the hindbrain by the isthmus[ISBN:0471888893]. Subdivision of the midbrain lying anterior to the tectum and posterior to the substantia nigra and cerebral peduncle[FMA] The part of the midbrain extending from the substantia nigra to the cerebral aqueduct in a horizontal section of the midbrain. It forms the floor of the midbrain that surrounds the cerebral aqueduct[WP]. + Together, our results reveal a shared basic organization in the tegmental domains of the diencephalon and midbrain of developing lamprey, indicating early appearance of the domain in vertebrate phylogeny.[well established][VHOG] + MTg + tegmentum + + + + + BAMS:MTg + BIRNLEX:1200 + BTO:0003388 + DHBA:12195 + EFO:0000921 + EHDAA2:0004475 + EMAPA:18215 + FMA:62393 + HBA:9002 + MA:0000212 + MAT:0000452 + TAO:0000160 + UMLS:C0039441 + VHOG:0001367 + XAO:0004271 + ZFA:0000160 + http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=491 + tegmentum mesencephali + tegmentum of midbrain + uberon + mesencephalic tegmentum + tegmentum mesencephalicum + UBERON:0001943 + + + + + 'tegmentum' is used generically for the ventral part of the brainstem (ISBN:0471888893). We use the label 'midbrain tegmentum' to denote the midbrain structure. In NIFSTD tegmentum is a composite structure and there is a separate class for midbrain tegmentum and pontine tegmentum + midbrain tegmentum + http://upload.wikimedia.org/wikipedia/commons/b/b6/Gray712.png + + + + + + + + + + + ZFA + + + + + Ventral part of the midbrain, separated from the hindbrain by the isthmus[ISBN:0471888893]. Subdivision of the midbrain lying anterior to the tectum and posterior to the substantia nigra and cerebral peduncle[FMA] The part of the midbrain extending from the substantia nigra to the cerebral aqueduct in a horizontal section of the midbrain. It forms the floor of the midbrain that surrounds the cerebral aqueduct[WP]. + + FMA:FMA + ISBN:0471888893 + + + + + Together, our results reveal a shared basic organization in the tegmental domains of the diencephalon and midbrain of developing lamprey, indicating early appearance of the domain in vertebrate phylogeny.[well established][VHOG] + 2012-09-17 + VHOG:0001367 + VHOG + + DOI:10.1016/j.brainresbull.2005.05.001 Villar-Cheda B, Abalo XM, Anadon R, Rodicio MC, The tegmental proliferation region in the sea lamprey. Brain Research Bulletin (2005) + + + + + MTg + BIRNLEX:1200 + NIFSTD:NeuroNames_abbrevSource + + + + + + tegmentum + ISBN:0471888893 + + + + + UMLS:C0039441 + BIRNLEX:1200 + + + + + http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=491 + BIRNLEX:1200 + + + + + tegmentum mesencephali + + + + + + + mesencephalic tegmentum + VHOG:0001367 + + + + + tegmentum mesencephalicum + NeuroNames:491 + + + + + + + + + + + + + + + + + + + + + + + + + + + + A multi-tissue structure that is part of a spinal cord. + + + BIRNLEX:1496 + NCIT:C33969 + UMLS:C1268166 + uberon + spinal cord part + UBERON:0001948 + + regional part of spinal cord + + + + + A multi-tissue structure that is part of a spinal cord. + OBOL:automatic + + + + + UMLS:C1268166 + ncithesaurus:Spinal_Cord_Part + + + + + + + + + + + + + + + + + + + + + + An area of cerebral cortex defined on the basis of cytoarchitecture that have six layers. Starting from the cortical surface the layers are: molecular layer (I), external granular layer (II), external pyramidal layer (III), internal granular layer (IV), internal pyramidal layer (V), and multiform layer (VI). Neocortex is most prominent in the frontal lobe, the parietal lobe, the temporal lobe and the occipital lobe, less so in the cingulate gyrus, the parahippocampal gyrus and the insula. It is composed of two subdivisions: true isocortex and proisocortex (Carpenter-83)(NN) + The 6-layer neocortex is well conserved in all extant mammals, but not present in birds or reptils + + + + BAMS:ISO + BAMS:Iso-cortex + BAMS:NCX + BIRNLEX:2547 + BTO:0000920 + DHBA:10160 + EHDAA2:0004662 + EMAPA:32842 + EMAPA:35589 + FMA:62429 + GAID:677 + MA:0002754 + MBA:315 + MESH:A08.186.211.730.885.213.420 + PBA:294021746 + UMLS:C0175173 + http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=757 + cerebral neocortex + homogenetic cortex + homotypical cortex + isocortex (sensu lato) + neocortex (isocortex) + neopallial cortex + neopallium + isocortex + uberon + iso-cortex + nonolfactory cortex + nucleus hypoglossalis + UBERON:0001950 + + + neocortex + http://upload.wikimedia.org/wikipedia/commons/7/77/Neocortex.jpg + + + + + An area of cerebral cortex defined on the basis of cytoarchitecture that have six layers. Starting from the cortical surface the layers are: molecular layer (I), external granular layer (II), external pyramidal layer (III), internal granular layer (IV), internal pyramidal layer (V), and multiform layer (VI). Neocortex is most prominent in the frontal lobe, the parietal lobe, the temporal lobe and the occipital lobe, less so in the cingulate gyrus, the parahippocampal gyrus and the insula. It is composed of two subdivisions: true isocortex and proisocortex (Carpenter-83)(NN) + BIRNLEX:2547 + OldNeuroNames:754 + + + + + The 6-layer neocortex is well conserved in all extant mammals, but not present in birds or reptils + + + + + + UMLS:C0175173 + BIRNLEX:2547 + + + + + http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=757 + BIRNLEX:2547 + + + + + homogenetic cortex + ISBN:0471888893 + + + + + + homotypical cortex + BIRNLEX:2547 + + + + + isocortex (sensu lato) + FMA:62429 + + + + + neocortex (isocortex) + DHBA:10160 + + + + + isocortex + BRAINSPAN:BRAINSPAN + + + + + iso-cortex + BAMS:iso-cortex + + + + + nonolfactory cortex + BTO:0000920 + + + + + nucleus hypoglossalis + NeuroNames:757 + + + + + + + + + + + + + + + + + The liquid component of blood, in which erythrocytes are suspended. + plasma + portion of plasma + + + BTO:0000131 + CALOHA:TS-0800 + EFO:0001905 + EMAPA:35690 + FMA:62970 + GAID:1178 + MA:0002501 + MAT:0000052 + MESH:D010949 + MIAA:0000052 + NCIT:C13356 + OpenCyc:Mx4rEg4ZYrIbEduAAAAOpmP6tw + UMLS:C0032105 + blood plasm + portion of blood plasma + uberon + UBERON:0001969 + + + + blood plasma + + + + + The liquid component of blood, in which erythrocytes are suspended. + + + + + + plasma + MA:0002501 + + + + + portion of plasma + FMA:62970 + + + + + UMLS:C0032105 + ncithesaurus:Plasma + + + + + + + + + + + + + + + + + + + + + One of the minute vessels that collect deoxygenated blood from the capillary plexuses returns it to the veins + Multi-tissue structure part of the blood vasculature formed by the anastomosis of capillaries. Venules carry blood toward the heart.[TAO] + + + + BTO:0002626 + EMAPA:35917 + FMA:63130 + MA:0000071 + MESH:A07.231.432.952 + NCIT:C12818 + TAO:0005315 + UMLS:C0042520 + VHOG:0001765 + ZFA:0005315 + uberon + venula + UBERON:0001979 + + + + venule + Illu:capillary.jpg + + + + + One of the minute vessels that collect deoxygenated blood from the capillary plexuses returns it to the veins + MESH:A07.231.432.952 + MP:0004125 + + + + + Multi-tissue structure part of the blood vasculature formed by the anastomosis of capillaries. Venules carry blood toward the heart.[TAO] + 2012-08-14 + TAO:0005315 + TAO + ZFIN:curator + + + + + UMLS:C0042520 + ncithesaurus:Venule + + + + + venula + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The smallest division of the artery located between the muscular arteries and the capillaries[GO]. + Multi-tissue structure part of the blood vasculature, feeds into capillaries. Arterioles carry blood away from the heart.[TAO] + Small, terminal branch of an artery which generally connects to capillaries.[AAO] + + + + AAO:0010253 + BTO:0001997 + EMAPA:35146 + FMA:63182 + MA:0000063 + MESH:D001160 + NCIT:C12672 + TAO:0002138 + UMLS:C0003847 + VHOG:0001763 + ZFA:0005255 + uberon + arteriola + UBERON:0001980 + + + + arteriole + Illu:capillary.jpg + + + + + + MA + + + + + The smallest division of the artery located between the muscular arteries and the capillaries[GO]. + GO:0014830 + + + + + Multi-tissue structure part of the blood vasculature, feeds into capillaries. Arterioles carry blood away from the heart.[TAO] + 2012-08-14 + TAO:0002138 + TAO + ZFIN:curator + + + + + Small, terminal branch of an artery which generally connects to capillaries.[AAO] + 2012-06-20 + AAO:0010253 + AAO + AAO:BJB + + + + + UMLS:C0003847 + ncithesaurus:Arteriole + + + + + arteriola + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A vessel through which blood circulates in the body. + consider adopting the EMAPA superclass 'vascular element', which includes microvasculature (e.g. capillaries), vascular plexus + Any of the vessels through which blood circulates in the body. [XAO:0001011_][VHOG] + Any of the vessels through which blood circulates in the body.[AAO] + The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG] + annelids have blood vessels, but this class is not applicable to annelids. + FMA:63183 Blood vessel is categorized as 'general anatomical term'. Suggestion to map to region of vascular tree from Terry H at JAX + vascular element + + + + AAO:0011004 + AEO:0000207 + BTO:0001102 + CALOHA:TS-0080 + EFO:0000817 + EHDAA2:0003252 + EHDAA:240 + EMAPA:32743 + EMAPA:35993 + FMA:50722 + FMA:63183 + GAID:169 + MA:0000060 + MAT:0000393 + MESH:D001808 + NCIT:C12679 + NLXANAT:090901 + OpenCyc:Mx4rvVjxlpwpEbGdrcN5Y29ycA + TAO:0002137 + UMLS:C0005847 + VHOG:0001250 + XAO:0001011 + ZFA:0005314 + region of vascular tree organ + vascular tree organ region + uberon + vas sanguineum + UBERON:0001981 + + + + + blood vessel + http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg + + + + + + + + + + + EHDAA2 + + + + + + + + + + + GO:0072360 + + + + + A vessel through which blood circulates in the body. + + BTO:0001102 + + + + + Any of the vessels through which blood circulates in the body. [XAO:0001011_][VHOG] + 2012-09-17 + VHOG:0001250 + VHOG + + + + + + Any of the vessels through which blood circulates in the body.[AAO] + 2012-06-20 + AAO:0011004 + AAO + AAO:EJS + + + + + The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG] + 2012-09-17 + VHOG:0001250 + VHOG + + DOI:10.1196/annals.1341.002 Bishopric NH, Evolution of the heart from bacteria to man. Annals of the New York Academy of Sciences (2006) + + + + + FMA:63183 Blood vessel is categorized as 'general anatomical term'. Suggestion to map to region of vascular tree from Terry H at JAX + FMA + + + + + vascular element + EMAPA:35993 + + + + + UMLS:C0005847 + ncithesaurus:Blood_Vessel + + + + + region of vascular tree organ + FMA:50722 + + + + + vascular tree organ region + FMA:50722 + + + + + vas sanguineum + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any of the smallest blood vessels connecting arterioles with venules. + not all sources agree capillary is a blood vessel - consider adopting EMAPA superclass of vascular element + Any of the tiny blood vessels connecting the arterioles to the venules.[AAO] + The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG] + capillaries lack tunica media and tunica adventitia; only the endothelial wall of the tunica intima belongs + + + AAO:0010252 + BTO:0002045 + CALOHA:TS-2006 + EFO:0001906 + EMAPA:35198 + EV:0100035 + FMA:63194 + MA:0000065 + MESH:A07.231.432.410 + NCIT:C12685 + NLXANAT:090902 + OpenCyc:Mx4rvWEU-5wpEbGdrcN5Y29ycA + TAO:0005250 + UMLS:C0935624 + VHOG:0001253 + XAO:0000116 + ZFA:0005250 + blood capillary + capillary vessel + uberon + UBERON:0001982 + + + + + capillary + http://upload.wikimedia.org/wikipedia/commons/2/2f/A_red_blood_cell_in_a_capillary,_pancreatic_tissue_-_TEM.jpg + + + + + + FMA + MA + XAO + + + + + + ZFA + + + + + Any of the smallest blood vessels connecting arterioles with venules. + + + ISBN:0073040584 + + + + + Any of the tiny blood vessels connecting the arterioles to the venules.[AAO] + 2012-06-20 + AAO:0010252 + AAO + AAO:BJB + + + + + The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG] + 2012-09-17 + VHOG:0001253 + VHOG + + DOI:10.1196/annals.1341.002 Bishopric NH, Evolution of the heart from bacteria to man. Annals of the New York Academy of Sciences (2006) + + + + + UMLS:C0935624 + ncithesaurus:Capillary + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A monolayer of specialized, flattened, mitochondria-rich cells that lines the posterior surface of the cornea and faces the anterior chamber of the eye[WP]. + + + + CALOHA:TS-0172 + EMAPA:35935 + FMA:63882 + GAID:891 + MA:0001242 + MESH:D004728 + NCIT:C12707 + TAO:0002186 + UMLS:C0014259 + ZFA:0001687 + cornea endothelium + endothelium of cornea + uberon + epithelium posterius corneae + UBERON:0001985 + + + + corneal endothelium + http://upload.wikimedia.org/wikipedia/commons/6/66/Gray871.png + + + + + A monolayer of specialized, flattened, mitochondria-rich cells that lines the posterior surface of the cornea and faces the anterior chamber of the eye[WP]. + + + + + + UMLS:C0014259 + ncithesaurus:Corneal_Endothelium + + + + + cornea endothelium + OBOL:automatic + + + + + endothelium of cornea + OBOL:automatic + + + + + epithelium posterius corneae + + + + + + + + + + + + A layer of epithelium that lines the heart, blood vessels (endothelium, vascular), lymph vessels (endothelium, lymphatic), and the serous cavities of the body[MESH]. Simple squamous epithelium which lines blood and lymphatic vessels and the heart[FMA] + endothelial + + + BTO:0000393 + CALOHA:TS-0278 + EFO:0002548 + FMA:63916 + GAID:520 + MESH:D004727 + NCIT:C12481 + UMLS:C0014257 + galen:Endothelium + uberon + UBERON:0001986 + + + The term 'endothelium' has been either restricted to the continuous cell layer of the vertebrates, as we are assuming here, or applied to all the cells able to adhere to the luminal surface of the vascular basement membrane (Casley-Smith 1980) + endothelium + + + + + + + FMA-text-def + + + + + A layer of epithelium that lines the heart, blood vessels (endothelium, vascular), lymph vessels (endothelium, lymphatic), and the serous cavities of the body[MESH]. Simple squamous epithelium which lines blood and lymphatic vessels and the heart[FMA] + + FMA:63916 + MESH:A10.272.491 + + + + + UMLS:C0014257 + ncithesaurus:Endothelium + + + + + + + + + A nervous system structure composed primarily of nerve cell bodies (somas). May also include dendrites and the initial unmyelinated portion of axons. + Multi-tissue comprised of neurons, dendrites, axon terminals, glial cells, and capillaries.[TAO] + + + + AEO:0001012 + EHDAA2:0003136 + EHDAA2_RETIRED:0004658 + EMAPA:37596 + FMA:67242 + HBA:4006 + MA:0001112 + NCIT:C32695 + OpenCyc:Mx4rwDdKMpwpEbGdrcN5Y29ycA + TAO:0002197 + UMLS:C0018220 + VHOG:0001768 + ZFA:0001681 + gray matter + gray matter of neuraxis + grey matter + grey matter of neuraxis + grey substance + neuronal grey matter + substantia grisea + uberon + gray mater + grisea + UBERON:0002020 + + + + gray matter + Spinal:nerve.svg + + + + + A nervous system structure composed primarily of nerve cell bodies (somas). May also include dendrites and the initial unmyelinated portion of axons. + + + + + + + Multi-tissue comprised of neurons, dendrites, axon terminals, glial cells, and capillaries.[TAO] + 2012-08-14 + TAO:0002197 + TAO + ZFIN:curator + + + + + EMAPA:37596 + MA:th + + + + + UMLS:C0018220 + ncithesaurus:Gray_Matter + + + + + gray matter of neuraxis + FMA:67242 + + + + + neuronal grey matter + AEO:0001012 + + + + + substantia grisea + FMA:67242 + FMA:TA + + + + + + gray mater + ZFA:0001681 + + + + + grisea + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The most posterior of the three principal regions of the brain. In mammals and birds the hindbrain is divided into a rostral metencephalon and a caudal myelencephalon. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata (From: Neuroanatomy of the Zebrafish Brain)[ZFA]. Organ component of neuraxis that has as its parts the pons, cerebellum and medulla oblongata[FMA]. + + Posterior part of the brain consisting of the cerebellum and medulla oblongata.[AAO] + The most posterior of the three principal regions of the brain, forming the rhombencephalon and all or most of the metencephalon. Kimmel et al, 1995.[TAO] + relationship loss: develops_from hindbrain neural tube (TAO:0007043)[TAO] + Fine structural, computerized three-dimensional (3D) mapping of cell connectivity in the amphioxus nervous system and comparative molecular genetic studies of amphioxus and tunicates have provided recent insights into the phylogenetic origin of the vertebrate nervous system. The results suggest that several of the genetic mechanisms for establishing and patterning the vertebrate nervous system already operated in the ancestral chordate and that the nerve cord of the proximate invertebrate ancestor of the vertebrates included a diencephalon, midbrain, hindbrain, and spinal cord.[well established][VHOG] + rhombencephalic + in MA, brainstem and hindbrain and part-of siblings under brain, consistent with FMA and NIF. See also notes for cerebellum. We weaken the relation in ABA to overlaps + + + + + + AAO:0010150 + BAMS:HB + BIRNLEX:942 + BTO:0000672 + CALOHA:TS-0457 + DHBA:10653 + DMBA:16808 + EFO:0000923 + EHDAA2:0000746 + EHDAA:3514 + EHDAA:6487 + EMAPA:16916 + FMA:67687 + MA:0000195 + MAT:0000107 + MBA:1065 + MESH:D012249 + MIAA:0000107 + NCIT:C40336 + TAO:0000029 + UMLS:C0035507 + UMLS:C1522180 + VHOG:0000070 + XAO:0000015 + ZFA:0000029 + http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=540 + uberon + rhombencephalon + UBERON:0002028 + + + + + hindbrain + http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg + + + + + + + + + + + + + + + + modified-source-relation + ABA + + + + + + + + + + + Bgee:AN + + + + + The most posterior of the three principal regions of the brain. In mammals and birds the hindbrain is divided into a rostral metencephalon and a caudal myelencephalon. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata (From: Neuroanatomy of the Zebrafish Brain)[ZFA]. Organ component of neuraxis that has as its parts the pons, cerebellum and medulla oblongata[FMA]. + + ZFA:0000029 + ZFIN:curator + + + + + + + + + + + Posterior part of the brain consisting of the cerebellum and medulla oblongata.[AAO] + 2012-06-20 + AAO:0010150 + AAO + AAO:BJB + + + + + The most posterior of the three principal regions of the brain, forming the rhombencephalon and all or most of the metencephalon. Kimmel et al, 1995.[TAO] + 2012-08-14 + TAO:0000029 + TAO + ZFIN:curator + + + + + relationship loss: develops_from hindbrain neural tube (TAO:0007043)[TAO] + 2012-08-14 + TAO:0000029 + TAO + + + + + Fine structural, computerized three-dimensional (3D) mapping of cell connectivity in the amphioxus nervous system and comparative molecular genetic studies of amphioxus and tunicates have provided recent insights into the phylogenetic origin of the vertebrate nervous system. The results suggest that several of the genetic mechanisms for establishing and patterning the vertebrate nervous system already operated in the ancestral chordate and that the nerve cord of the proximate invertebrate ancestor of the vertebrates included a diencephalon, midbrain, hindbrain, and spinal cord.[well established][VHOG] + 2012-09-17 + VHOG:0000070 + VHOG + + DOI:10.1016/S0959-4388(99)00003-3 Holland LZ and Holland ND, Chordate origins of the vertebrate central nervous system. Current Opinion in Neurobiology (1999) + + + + + in MA, brainstem and hindbrain and part-of siblings under brain, consistent with FMA and NIF. See also notes for cerebellum. We weaken the relation in ABA to overlaps + MA + + + + + UMLS:C0035507 + BIRNLEX:942 + + + + + UMLS:C0035507 + ncithesaurus:Hind-Brain + + + + + UMLS:C1522180 + BIRNLEX:942 + + + + + http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=540 + BIRNLEX:942 + + + + + + + + + Muscle tissue that contains fibers that are divided by transverse bands into striations. + Voluntary muscle tissue arranged in bundles of fibers.[AAO] + + + AAO:0010762 + AEO:0000140 + CALOHA:TS-2047 + EHDAA2:0003140 + EMAPA:36390 + FMA:67905 + MA:0002438 + NCIT:C12436 + OpenCyc:Mx4rwAoze5wpEbGdrcN5Y29ycA + UMLS:C1331262 + WBbt:0005779 + galen:StriatedMuscle + striated muscle + uberon + UBERON:0002036 + + + striated muscle tissue + + + + + Muscle tissue that contains fibers that are divided by transverse bands into striations. + CL:0000737 + GOC:dph + GOC:mtg_muscle + + + + + Voluntary muscle tissue arranged in bundles of fibers.[AAO] + 2012-06-20 + AAO:0010762 + AAO + AAO:CAM + + + + + UMLS:C1331262 + ncithesaurus:Striated_Muscle_Tissue + + + + + + + + + + + + + + + + + + + + + + + + + + + An interconnected tubular multi-tissue structure contains fluid that is actively transported around the organism[ZFA]. Examples: vasculature of lung, vasculature of face. + see also: vascular system. Consider merging? + vascular + BTO:0003718 + FMA:69050 + TAO:0005249 + ZFA:0005249 + vascular network + uberon + UBERON:0002049 + + + + vasculature + http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg + + + + + + FMA + + + + + An interconnected tubular multi-tissue structure contains fluid that is actively transported around the organism[ZFA]. Examples: vasculature of lung, vasculature of face. + ZFA:0005249 + + + + + vascular network + FMA:69050 + + + + + + + + + + + + + + + + + + + + + + + + + + Anatomical structure that is part of an embryo. + Anatomical structure that is part of the embryo and is comprised of portions of tissue or cells.[AAO] + Anatomical structure that is part of the embryo and is comprised of portions of tissue or cells.[TAO] + Anatomical structure that is part of the embryo and is comprised of portions of tissue or cells.[VSAO] + in FMA embryo is_a embryonic structure + + + AAO:0000138 + BILA:0000034 + BTO:0000174 + CALOHA:TS-2110 + EFO:0000461 + FBbt:00004208 + FMA:69067 + GAID:407 + MESH:D004628 + NCIT:C13229 + RETIRED_EHDAA2:0003169 + TAO:0001105 + UMLS:C0013948 + VSAO:0000178 + XAO:0003042 + ZFA:0001105 + developing embryonic structure + embryonic anatomical structure + uberon + developing structure + embryonale Struktur + embryonic structures + UBERON:0002050 + + + + embryonic structure + + + + + Anatomical structure that is part of an embryo. + BTO:0000174 + ZFIN:curator + + + + + Anatomical structure that is part of the embryo and is comprised of portions of tissue or cells.[AAO] + 2012-06-20 + AAO:0000138 + AAO + AAO:BJB + + + + + Anatomical structure that is part of the embryo and is comprised of portions of tissue or cells.[TAO] + 2012-08-14 + TAO:0001105 + TAO + ZFIN:curator + + + + + Anatomical structure that is part of the embryo and is comprised of portions of tissue or cells.[VSAO] + 2012-08-14 + VSAO:0000178 + VSAO + ZFIN:curator + + + + + in FMA embryo is_a embryonic structure + FMA + + + + + UMLS:C0013948 + ncithesaurus:Embryonic_Structure + + + + + developing embryonic structure + FBbt:00004208 + + + + + embryonic anatomical structure + RETIRED_EHDAA2:0003169 + + + + + embryonale Struktur + BTO:0000174 + + + + + embryonic structures + ZFA:0001105 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The dermis is a layer of skin between the epidermis (with which it makes up the skin) and subcutaneous tissues, and is composed of two layers, the papillary and reticular dermis[WP]. + Consider adding a layer-of-skin grouping class for all skin layers + A collagenous layer of the skin subjacent to the epidermis and covering the hypodermis. It contains various types of cells (e.g. fibroblasts, pigment cells, nerve, blood vessels and scales. Le Guellec et al, 2004.[TAO] + When approaching controversies surrounding skin evolution, we need to remember that the skin consists of two layers, an epidermis and a dermis, not a single evolving structure. (...) It is little wonder that controversies about homology exist. If we think of the epidermis, the dermis, and their interactions as an evolving unit, then their specialized products (hair, feathers, and reptilian scales) are broadly homologous.[well established][VHOG] + dermal + + + + AAO:0000128 + BTO:0000294 + CALOHA:TS-2076 + EFO:0000953 + EMAPA:17527 + EV:0100154 + FMA:70323 + GAID:1321 + MA:0000152 + MAT:0000153 + MESH:D020405 + MIAA:0000153 + NCIT:C12701 + TAO:0001119 + UMLS:C0011646 + VHOG:0000108 + XAO:0000217 + ZFA:0001119 + vertebrate dermis + uberon + corium + cutis + UBERON:0002067 + + + + + dermis + http://upload.wikimedia.org/wikipedia/commons/2/23/EpidermisPainted.svg + + + + + + + + + + + FMA + + + + + + + + + + + definitional + + + + + The dermis is a layer of skin between the epidermis (with which it makes up the skin) and subcutaneous tissues, and is composed of two layers, the papillary and reticular dermis[WP]. + + ZFIN:curator + + + + + A collagenous layer of the skin subjacent to the epidermis and covering the hypodermis. It contains various types of cells (e.g. fibroblasts, pigment cells, nerve, blood vessels and scales. Le Guellec et al, 2004.[TAO] + 2012-08-14 + TAO:0001119 + TAO + ZFIN:curator + + + + + When approaching controversies surrounding skin evolution, we need to remember that the skin consists of two layers, an epidermis and a dermis, not a single evolving structure. (...) It is little wonder that controversies about homology exist. If we think of the epidermis, the dermis, and their interactions as an evolving unit, then their specialized products (hair, feathers, and reptilian scales) are broadly homologous.[well established][VHOG] + 2012-09-17 + VHOG:0000108 + VHOG + + ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.231-232 see also p.209 and p.228 and Figure 6-1 + + + + + UMLS:C0011646 + ncithesaurus:Dermis + + + + + corium + + + + + + + corium + BTO:0000294 + + + + + cutis + BTO:0000294 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Lowermost layer of the integumentary system in vertebrates. Types of cells that are found in the hypodermis are fibroblasts, adipose cells, and macrophages. It is derived from the mesoderm, but unlike the dermis, it is not derived from the dermatome region of the mesoderm. The hypodermis is used mainly for fat storage[WP]. + A layer separating the inner face of the dermis from the subjacent muscle cells. It is covered on both sides by a basement membrane. It contains pigment cells. Le Guellec et al, 2004.[TAO] + A layer separating the inner face of the dermis from the subjacent muscle cells. It is covered on both sides by a basement membrane. It contains pigment cells[FMA:70544]. + hypodermal + subcutaneous + subcutaneus + BTO has 'subcutis', as part of dermis. We follow FMA in having distinct classes for hypodermis and superficial fascia, and including these as part of the non-skin intgeument. + + + BTO:0001314 + CALOHA:TS-2366 + EMAPA:37505 + FMA:70544 + NCIT:C33645 + TAO:0001136 + UMLS:C0278403 + ZFA:0001136 + hypoderm + vertebrate hypodermis + uberon + sub-tegumental tissue + subcutaneous tissue + subcutis + subtegumental tissue + superficial fascia + tela subcutanea + UBERON:0002072 + + + + hypodermis + http://upload.wikimedia.org/wikipedia/commons/6/6d/Skin.svg + + + + + + + + + + + ZFA + + + + + + + + + + + FMA-modified + + + + + Lowermost layer of the integumentary system in vertebrates. Types of cells that are found in the hypodermis are fibroblasts, adipose cells, and macrophages. It is derived from the mesoderm, but unlike the dermis, it is not derived from the dermatome region of the mesoderm. The hypodermis is used mainly for fat storage[WP]. + + + + + + A layer separating the inner face of the dermis from the subjacent muscle cells. It is covered on both sides by a basement membrane. It contains pigment cells. Le Guellec et al, 2004.[TAO] + 2012-08-14 + TAO:0001136 + TAO + ZFIN:curator + + + + + A layer separating the inner face of the dermis from the subjacent muscle cells. It is covered on both sides by a basement membrane. It contains pigment cells[FMA:70544]. + FMA:70544 + + + + + BTO has 'subcutis', as part of dermis. We follow FMA in having distinct classes for hypodermis and superficial fascia, and including these as part of the non-skin intgeument. + BTO + + + + + EMAPA:37505 + MA:th + + + + + UMLS:C0278403 + ncithesaurus:Subcutis + + + + + sub-tegumental tissue + BTO:0004525 + + + + + subcutaneous tissue + + + + + + subtegumental tissue + BTO:0004525 + + + + + superficial fascia + + + + + + tela subcutanea + + + + + + + + + + + + + + + + + + + + + + + + + + + + An organ that is located within the body cavity (or in its extension, in the scrotum); it consists of organ parts that are embryologically derived from endoderm, splanchnic mesoderm or intermediate mesoderm; together with other organs, the viscus constitutes the respiratory, gastrointestinal, urinary, reproductive and immune systems, or is the central organ of the cardiovascular system. Examples: heart, lung, esophagus, kidney, ovary, spleen. + An internal organ of the body; especially: one (as the heart, liver, or intestine) located in the great cavity of the trunk proper.[AAO] + general anatomical term in FMA. Note that we place the MA class here temporarily, although properly systems should be distinguished from organs. + + + + AAO:0010386 + BTO:0001491 + EHDAA:512 + EMAPA:16245 + FMA:7085 + MA:0000019 + MESH:D014781 + NCIT:C28287 + RETIRED_EHDAA2:0002201 + UMLS:C0042779 + XAO:0003034 + visceral organ + visceral organ system + uberon + Organsystem@de + splanchnic tissue + viscera + visceral tissue + UBERON:0002075 + + + + + viscus + + + + + An organ that is located within the body cavity (or in its extension, in the scrotum); it consists of organ parts that are embryologically derived from endoderm, splanchnic mesoderm or intermediate mesoderm; together with other organs, the viscus constitutes the respiratory, gastrointestinal, urinary, reproductive and immune systems, or is the central organ of the cardiovascular system. Examples: heart, lung, esophagus, kidney, ovary, spleen. + + + BTO:0001491 + + + + + An internal organ of the body; especially: one (as the heart, liver, or intestine) located in the great cavity of the trunk proper.[AAO] + 2012-06-20 + AAO:0010386 + AAO + BTO:0001491 + + + + + general anatomical term in FMA. Note that we place the MA class here temporarily, although properly systems should be distinguished from organs. + FMA + + + + + UMLS:C0042779 + ncithesaurus:Viscera + + + + + visceral organ + RETIRED_EHDAA2:0002201 + + + + + visceral organ system + MA:0000019 + + + + + Organsystem@de + BTO:0001491 + + + + + splanchnic tissue + BTO:0001491 + + + + + visceral tissue + BTO:0001491 + + + + + + + + + + + + + + + + + + + + + + + + + + + Cardiac chamber in which blood enters the heart. + One of four heart chambers.[TAO] + One of two chambers of the heart which receive blood from the veins and forces it by muscular contration to the ventricle.[AAO] + In the primitive vertebrate heart the four chambers are: 1. Sinus venosus (...) 2. Atrium (...) 3. Ventricle (...) 4. Conus arteriosus (...).[well established][VHOG] + + + + AAO:0010246 + BTO:0000903 + CALOHA:TS-0437 + EFO:0000277 + EHDAA2:0000154 + EHDAA:1265 + EMAPA:16688 + EV:0100019 + FMA:7099 + GAID:555 + MA:0000073 + MAT:0000496 + MESH:D006325 + NCIT:C12728 + TAO:0000471 + UMLS:C0018792 + VHOG:0000175 + ZFA:0000471 + galen:Atrium + atria + atrium + atrium of heart + cardiac atria + heart atrium + uberon + atrial tissue + UBERON:0002081 + + + + + cardiac atrium + + + + + Cardiac chamber in which blood enters the heart. + + + + + + + One of four heart chambers.[TAO] + 2012-08-14 + TAO:0000471 + TAO + ZFIN:curator + + + + + One of two chambers of the heart which receive blood from the veins and forces it by muscular contration to the ventricle.[AAO] + 2012-06-20 + AAO:0010246 + AAO + AAO:BJB + + + + + In the primitive vertebrate heart the four chambers are: 1. Sinus venosus (...) 2. Atrium (...) 3. Ventricle (...) 4. Conus arteriosus (...).[well established][VHOG] + 2012-09-17 + VHOG:0000175 + VHOG + + ISBN:978-0721676678 Romer AS, Vertebrate body (1970) p.428 + + + + + UMLS:C0018792 + ncithesaurus:Cardiac_Atrium + + + + + atria + + + + + + atrium + ZFA:0000471 + + + + + cardiac atria + + + + + + atrial tissue + BTO:0000903 + + + + + + + + + + + + + + + + + + + + + + + + + + + Cardiac chamber through which blood leaves the heart. + A chamber of the heart that receives blood from one or more atria and pumps it by muscular contraction into the arteries.[AAO] + One of four heart chambers.[TAO] + In the primitive vertebrate heart the four chambers are: 1. Sinus venosus (...) 2. Atrium (...) 3. Ventricle (...) 4. Conus arteriosus (...)[well established][VHOG] + ventricle + + + + AAO:0010249 + BTO:0000862 + CALOHA:TS-0444 + EFO:0000317 + EHDAA2:0004164 + EHDAA:1912 + EMAPA:17331 + EV:0100020 + FMA:7100 + GAID:568 + MA:0000091 + MAT:0000497 + MESH:D006352 + NCIT:C12730 + OpenCyc:Mx4rvVjj1pwpEbGdrcN5Y29ycA + TAO:0000009 + UMLS:C0018827 + VHOG:0000435 + XAO:0003193 + ZFA:0000009 + galen:Ventricle + heart ventricle + lower chamber of heart + ventricle of heart + uberon + UBERON:0002082 + + + + + cardiac ventricle + + + + + + + + + + + Bgee:AN + + + + + Cardiac chamber through which blood leaves the heart. + + + + + + + A chamber of the heart that receives blood from one or more atria and pumps it by muscular contraction into the arteries.[AAO] + 2012-06-20 + AAO:0010249 + AAO + AAO:BJB + + + + + One of four heart chambers.[TAO] + 2012-08-14 + TAO:0000009 + TAO + ZFIN:curator + + + + + In the primitive vertebrate heart the four chambers are: 1. Sinus venosus (...) 2. Atrium (...) 3. Ventricle (...) 4. Conus arteriosus (...)[well established][VHOG] + 2012-09-17 + VHOG:0000435 + VHOG + + ISBN:978-0721676678 Romer AS, Vertebrate body (1970) p.428 + + + + + UMLS:C0018827 + ncithesaurus:Cardiac_Ventricle + + + + + + + + + + + + + + + + + + + + + + + + + + + + The postcranial subdivision of skeleton structural components forming the long axis of the vertebrate body; in Danio, consisting of the notochord, vertebrae, ribs, supraneurals, intermuscular bones, and unpaired median fins; in human consists of the bones of the vertebral column, the thoracic cage and the pelvis[ZFA+FMA]. + Skeletal subdivision of the central body axis including vertebrae, notochord, ribs, and sternum.[VSAO] + The axial skeleton is formed by the vertebral column, a metameric, semi-flexible, arched bar located in the dorsal part of the trunk, and is formed by a series of cartilaginous or bony vertebrae. It provides suspension for the appendicular skeleton and protection for the spinal nerve cord.[AAO] + The post-cranial structural components forming the long axis of the vertebrate body; usually consists of the notochord, vertebrae, ribs, supraneurals, intermuscular bones, and unpaired median fins.[TAO] + The axial musculoskeletal system represents the plesiomorphic locomotor engine of the vertebrate body, playing a central role in locomotion. In craniates, the evolution of the postcranial skeleton is characterized by two major transformations. First, the axial skeleton became increasingly functionally and morphologically regionalized. Second, the axial-based locomotion plesiomorphic for craniates became progressively appendage-based with the evolution of extremities in tetrapods.[well established][VHOG] + axial skeleton + AAO:0000034 + EFO:0000942 + EHDAA2:0000161 + EHDAA:5049 + EMAPA:17214 + EMAPA:37721 + FMA:71221 + MA:0002986 + MAT:0000148 + MIAA:0000148 + TAO:0000317 + VHOG:0000317 + VSAO:0000093 + XAO:0003073 + ZFA:0000317 + post-cranial axial skeleton + uberon + UBERON:0002090 + + + + + previous some AOs had used the term 'axial skeleton' to include the skull. This is being resolved (see tracker items above). Status: MA - fixed. + postcranial axial skeleton + http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton + + + + + The postcranial subdivision of skeleton structural components forming the long axis of the vertebrate body; in Danio, consisting of the notochord, vertebrae, ribs, supraneurals, intermuscular bones, and unpaired median fins; in human consists of the bones of the vertebral column, the thoracic cage and the pelvis[ZFA+FMA]. + + + ZFA:0000317 + + + + + Skeletal subdivision of the central body axis including vertebrae, notochord, ribs, and sternum.[VSAO] + 2012-08-14 + VSAO:0000093 + VSAO + PSPUB:0000170 + + + + + The axial skeleton is formed by the vertebral column, a metameric, semi-flexible, arched bar located in the dorsal part of the trunk, and is formed by a series of cartilaginous or bony vertebrae. It provides suspension for the appendicular skeleton and protection for the spinal nerve cord.[AAO] + 2012-06-20 + AAO:0000034 + AAO + AAO:LAP + + + + + The post-cranial structural components forming the long axis of the vertebrate body; usually consists of the notochord, vertebrae, ribs, supraneurals, intermuscular bones, and unpaired median fins.[TAO] + 2012-08-14 + TAO:0000317 + TAO + ZFIN:curator + + + + + The axial musculoskeletal system represents the plesiomorphic locomotor engine of the vertebrate body, playing a central role in locomotion. In craniates, the evolution of the postcranial skeleton is characterized by two major transformations. First, the axial skeleton became increasingly functionally and morphologically regionalized. Second, the axial-based locomotion plesiomorphic for craniates became progressively appendage-based with the evolution of extremities in tetrapods.[well established][VHOG] + 2012-09-17 + VHOG:0000317 + VHOG + + DOI:10.1186/1742-9994-8-4 Schilling N, Evolution of the axial system in craniates: morphology and function of the perivertebral musculature. Frontiers in Zoology (2011) + + + + + axial skeleton + + FMA:71221 + + + + + EMAPA:37721 + MA:th + + + + + + + + + + + + + + + + + + + + + + + + + + + + The organ covering the body that consists of the dermis and epidermis. + consider 'integumentary system' for invertebrates + MA uses the term skin to refer to what is called here: zone of skin + + + + BTO:0001253 + CALOHA:TS-0934 + EFO:0000962 + EHDAA2:0001844 + EMAPA:17525 + FMA:7163 + MESH:D012867 + MFMO:0000099 + NCIT:C12470 + OpenCyc:Mx4rvVjX3ZwpEbGdrcN5Y29ycA + UMLS:C1123023 + XAO:0000023 + galen:Skin + entire skin + skin organ + uberon + entire integument + integument + integumental organ + pelt + skin + UBERON:0002097 + + + + + skin of body + http://upload.wikimedia.org/wikipedia/commons/6/6d/Skin.svg + + + + + + + + + + + Wikipathways:WP2062 + + + + + The organ covering the body that consists of the dermis and epidermis. + UBERON:cjm + + + + + MA uses the term skin to refer to what is called here: zone of skin + FMA + + + + + UMLS:C1123023 + ncithesaurus:Skin + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The thin membranous structure between the two heart atria or the thick muscular structure between the two heart ventricles. + 'Terrestrial vertebrates have divided hearts in which septae separate the oxygenated and deoxygenated blood within the pulmonary and systemic circulations' + in GO, septum morphogenesis is part of cardiac chamber morphogenesis; need to add axioms to infer this + + + EMAPA:35400 + FMA:7180 + GAID:562 + MA:0000083 + MESH:D006346 + NCIT:C49485 + UMLS:C0018819 + XAO:0004141 + cardiac septa + heart septa + heart septum + septum of heart + uberon + spiral septa + UBERON:0002099 + + + cardiac septum + + + + + The thin membranous structure between the two heart atria or the thick muscular structure between the two heart ventricles. + MESH:A07.541.459 + + + + + in GO, septum morphogenesis is part of cardiac chamber morphogenesis; need to add axioms to infer this + GO + + + + + UMLS:C0018819 + ncithesaurus:Heart_Septum + + + + + cardiac septa + + + + + + heart septa + + + + + + spiral septa + XAO:0004141 + + + + + + + + + + + + + + + + Organism subdivision which is the part of the body posterior to the cervical region (or head, when cervical region not present) and anterior to the caudal region. Includes the sacrum when present. + Organism subdivision that is the part of the body posterior to the head and anterior to the tail.[AAO] + Organism subdivision which is the part of the body posterior to the head and anterior to the tail.[TAO] + + + + AAO:0010339 + BILA:0000116 + BTO:0001493 + CALOHA:TS-1071 + EFO:0000966 + EMAPA:31857 + FMA:7181 + MA:0000004 + MAT:0000296 + MIAA:0000296 + NCIT:C33816 + OpenCyc:Mx4rvVkJjpwpEbGdrcN5Y29ycA + TAO:0001115 + UMLS:C0460005 + XAO:0000054 + XAO:0003025 + ZFA:0001115 + galen:Trunk + thoracolumbar region + torso + trunk region + uberon + Rumpf + UBERON:0002100 + + + + + trunk + + + + + Organism subdivision which is the part of the body posterior to the cervical region (or head, when cervical region not present) and anterior to the caudal region. Includes the sacrum when present. + + TAO:0001115 + UBERONREF:0000006 + + + + + Organism subdivision that is the part of the body posterior to the head and anterior to the tail.[AAO] + 2012-06-20 + AAO:0010339 + AAO + AAO:BJB + + + + + Organism subdivision which is the part of the body posterior to the head and anterior to the tail.[TAO] + 2012-08-14 + TAO:0001115 + TAO + ZFIN:curator + + + + + UMLS:C0460005 + ncithesaurus:Trunk + + + + + trunk region + XAO:0000054 + + + + + Rumpf + BTO:0001493 + + + + + + + + + The sensory system subserving the sense of vision. + The sensory system used for sight.[AAO] + UBERON:0007036 + + + + + AAO:0000632 + BILA:0000140 + EMAPA:36003 + FMA:7191 + MA:0002444 + NCIT:C12888 + OpenCyc:Mx4rvViCtpwpEbGdrcN5Y29ycA + TAO:0001127 + UMLS:C0587900 + XAO:0003198 + ZFA:0001127 + photosensory system + visual organ system + uberon + UBERON:0002104 + + + + visual system + + + + + The sensory system subserving the sense of vision. + NIFSTD:FMAID_7191 + + + + + The sensory system used for sight.[AAO] + 2012-06-20 + AAO:0000632 + AAO + AAO:EJS + + + + + UMLS:C0587900 + ncithesaurus:Visual_System + + + + + photosensory system + BILA:0000140 + + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of smooth muscle tissue that is part of an artery [Automatically generated definition]. + + BTO:0000087 + CALOHA:TS-1198 + EMAPA:36285 + FMA:72024 + MA:0000708 + NCIT:C49195 + UMLS:C1706851 + arterial smooth muscle + artery smooth muscle + artery smooth muscle tissue + smooth muscle of artery + uberon + arterial smooth muscle cell + UBERON:0002111 + artery smooth muscle tissue + + + + + A portion of smooth muscle tissue that is part of an artery [Automatically generated definition]. + OBOL:automatic + + + + + UMLS:C1706851 + ncithesaurus:Artery_Smooth_Muscle_Tissue + + + + + arterial smooth muscle + BTO:0000087 + + + + + smooth muscle of artery + FMA:72024 + + + + + arterial smooth muscle cell + BTO:0000087 + + + + + + + + + + + + + + + + + + + + + + + + + + + + The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers[GO]. + Layer that lines the lumen of the heart.[TAO] + Part of the heart comprised of thin serous membrane, composed of endothelial tissue, that lines the interior of the heart.[AAO] + Tunica intima which has as its parts the endothelium of endocardium and the fibroelastic connective tissue that surrounds the cavity of a cardiac chamber. + UBERON:0006225 + + + + AAO:0010408 + BTO:0000387 + CALOHA:TS-2075 + EFO:0000821 + EHDAA2:0004153 + EMAPA:17868 + EMAPA:32686 + EV:0100021 + FMA:7280 + GAID:550 + MA:0000076 + MAT:0000455 + MESH:D004699 + NCIT:C13004 + OpenCyc:Mx4rsWA75K1cEduAAADggVaqvw + TAO:0001320 + UMLS:C0014124 + VHOG:0000084 + XAO:0000066 + ZFA:0001320 + galen:Endocardium + endocardial lining + endocardial tissue + heart endocardium + uberon + heart endocardial tissue + UBERON:0002165 + + + + + fixed in GO to reflect FMA. See email to David/Varsha June 18 2010 + endocardium + http://upload.wikimedia.org/wikipedia/commons/6/6c/Gray493.png + + + + + + + + + + + Bgee:AN + + + + + The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers[GO]. + GO:0003157 + + + + + Layer that lines the lumen of the heart.[TAO] + 2012-08-14 + TAO:0001320 + TAO + ZFIN:curator + + + + + Part of the heart comprised of thin serous membrane, composed of endothelial tissue, that lines the interior of the heart.[AAO] + 2012-06-20 + AAO:0010408 + AAO + AAO:BJB + + + + + Tunica intima which has as its parts the endothelium of endocardium and the fibroelastic connective tissue that surrounds the cavity of a cardiac chamber. + FMA:7280 + + + + + UMLS:C0014124 + ncithesaurus:Endocardium + + + + + endocardial lining + EMAPA:32686 + + + + + endocardial tissue + EMAPA:17868 + + + + + heart endocardial tissue + VHOG:0000084 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Endocardium that is part of the atrium. + + EMAPA:32745 + FMA:7284 + MA:0000077 + TAO:0002169 + VHOG:0000606 + ZFA:0001614 + Cardiac atria endocardium + atrial endocardium + atrium endocardium + atrium of heart endocardium + cardiac atrium endocardium + endocardium of Cardiac atria + endocardium of atrium of heart + endocardium of cardiac atrium + endocardium of heart atrium + heart atrium endocardium + uberon + atrium endocardial tissue + UBERON:0002166 + + + endocardium of atrium + + + + + Endocardium that is part of the atrium. + ZFIN:curator + + + + + Cardiac atria endocardium + OBOL:automatic + + + + + atrium of heart endocardium + OBOL:automatic + + + + + cardiac atrium endocardium + OBOL:automatic + + + + + endocardium of Cardiac atria + OBOL:automatic + + + + + endocardium of atrium of heart + OBOL:automatic + + + + + endocardium of cardiac atrium + OBOL:automatic + + + + + endocardium of heart atrium + OBOL:automatic + + + + + heart atrium endocardium + OBOL:automatic + + + + + atrium endocardial tissue + VHOG:0000606 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of adipose tissue that is part of the hypodermis, beneath the dermis. + the superficial portion of the subcutaneous tissue which is specialized for fat storage[MP:0011156] + UBERON:0008875 + panniculus adiposus + BTO:0004042 + EMAPA:35829 + FMA:74315 + MA:0000473 + fatty layer of subcutaneous tissue + hypodermis fat layer + panniculus adiposus (tela subcutanea) + panniculus adiposus telae subcutaneae + subcutaneous fat layer + uberon + fatty layer of superficial fascia + subcutaneous fat + UBERON:0002190 + + subcutaneous adipose tissue + + + + + A portion of adipose tissue that is part of the hypodermis, beneath the dermis. + + + + + + the superficial portion of the subcutaneous tissue which is specialized for fat storage[MP:0011156] + MP:0011156 + + + + + panniculus adiposus + MP:0011156 + + + + + fatty layer of subcutaneous tissue + FMA:74315 + + + + + hypodermis fat layer + MP:0011156 + + + + + panniculus adiposus (tela subcutanea) + FMA:74315 + FMA:TA + + + + + + panniculus adiposus telae subcutaneae + FMA:74315 + FMA:TA + + + + + + subcutaneous fat layer + MP:0011156 + + + + + fatty layer of superficial fascia + FMA:74315 + + + + + subcutaneous fat + BTO:0004042 + + + + + + + + + Anatomical cluster consisting of the hematopoietic system and the lymphoid system, or its analogs. + CALOHA:TS-2018 + EHDAA2:0004615 + EMAPA:18765 + FMA:74562 + MA:0000013 + hematolymphoid system + lymphomyeloid complex + uberon + haemolymphoid system + UBERON:0002193 + hemolymphoid system + + + + + + MA + + + + + Anatomical cluster consisting of the hematopoietic system and the lymphoid system, or its analogs. + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The dermis, epidermis and hypodermis. + in FMA intergument = skin+superficial fascia(hypodermis), skin=dermis+epidermis+hair_nail. Note that the definition provided here excludes the more general sense of the term 'integument' used in invertebrates; consider 'integumental system'. Note that the VSAO class appears to include adnexa by its definition. + Anatomical system that protects the body from damage, comprising the skin and its appendages.[AAO] + Surface structure that is the outer protective covering of the body.[VSAO] + The outer protective barrier that separates the animal from its aquatic environment. Le Guellec et al, 2004.[TAO] + integumental + integumentary + + AAO:0000239 + BTO:0000634 + EMAPA:37504 + FMA:74657 + TAO:0000368 + VSAO:0000029 + ZFA:0000368 + galen:Integument + dermis plus epidermis plus hypodermis + integumentum commune + skin and subcutaneous tissue + skin plus hypodermis + the integument + uberon + Hautsystem@de + dermal system + dermoid system + skin + tegument + vertebrate integument + UBERON:0002199 + + + + integument + + + + + + FMA + + + + + + + + + + + FMA + + + + + The dermis, epidermis and hypodermis. + + + + + + Anatomical system that protects the body from damage, comprising the skin and its appendages.[AAO] + 2012-06-20 + AAO:0000239 + AAO + AAO:EJS + + + + + Surface structure that is the outer protective covering of the body.[VSAO] + 2012-08-14 + VSAO:0000029 + VSAO + PSPUB:0000170 + + + + + The outer protective barrier that separates the animal from its aquatic environment. Le Guellec et al, 2004.[TAO] + 2012-08-14 + TAO:0000368 + TAO + ZFIN:curator + + + + + EMAPA:37504 + MA:th + + + + + integumentum commune + FMA:74657 + FMA:TA + + + + + + the integument + FMA:74657 + + + + + Hautsystem@de + BTO:0000634 + + + + + dermal system + BTO:0000634 + + + + + dermoid system + BTO:0000634 + + + + + tegument + BTO:0000634 + + + + + + + + + + + + + + + + + + + + + + + + + + Vasculature that is part of a head [Automatically generated definition]. + EFO:0003656 + FMA:74710 + TAO:0001267 + XAO:0004152 + ZFA:0001267 + adult head vascular network + adult head vasculature + cranial vasculature + head vascular network + vascular network of adult head + vascular network of head + vasculature of adult head + uberon + head vasculature + UBERON:0002200 + + + vasculature of head + + + + + Vasculature that is part of a head [Automatically generated definition]. + OBOL:automatic + + + + + adult head vascular network + OBOL:automatic + + + + + adult head vasculature + OBOL:automatic + + + + + head vascular network + OBOL:automatic + + + + + vascular network of adult head + OBOL:automatic + + + + + vascular network of head + OBOL:automatic + + + + + vasculature of adult head + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A vasculature that is part of a trunk [Automatically generated definition]. + FMA:74712 + TAO:0005024 + ZFA:0005024 + torso vascular network + torso vasculature + trunk vascular network + trunk vasculature + vascular network of torso + vascular network of trunk + vasculature of torso + uberon + UBERON:0002201 + + vasculature of trunk + + + + + A vasculature that is part of a trunk [Automatically generated definition]. + OBOL:automatic + + + + + torso vascular network + OBOL:automatic + + + + + torso vasculature + OBOL:automatic + + + + + trunk vascular network + OBOL:automatic + + + + + vascular network of torso + OBOL:automatic + + + + + vascular network of trunk + OBOL:automatic + + + + + vasculature of torso + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Vasculature that is part of the eye region. + not part of the eye in ZFA. Note this changed to a blood vessel in ZFA + + FMA:74743 + TAO:0007057 + ZFA:0007057 + eye vascular network + ocular blood vessel + ocular vasculature + vascular network of eye + uberon + eye vasculature + optic vasculature + UBERON:0002203 + + + vasculature of eye + + + + + + + + + + + ISBN:0781772214 + + + + + Vasculature that is part of the eye region. + + OBOL:automatic + + + + + not part of the eye in ZFA. Note this changed to a blood vessel in ZFA + ZFA + + + + + eye vascular network + OBOL:automatic + + + + + ocular blood vessel + ZFA:0007057 + + + + + vascular network of eye + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Anatomical system that consists of the muscular and skeletal systems. + Anatomical system that provides locomotion and physical support to the organism.[AAO] + There are more than 50,000 extant vertebrate species, representing over 500 million years of evolution. During that time, the vertebrate musculoskeletal systems have adapted to aquatic, terrestrial, fossorial, and arboreal lifestyles, while simultaneously retaining functionally integrated axial and appendicular skeletal systems.[well established][VHOG] + musculoskeletal + + + + + AAO:0010546 + CALOHA:TS-1311 + EMAPA:32714 + EV:0100139 + FMA:7482 + GAID:98 + MA:0002418 + MESH:D009141 + NCIT:C12754 + OpenCyc:Mx4rQRpVNgAKEdyHxgDggVfs8g + UMLS:C0026860 + VHOG:0001275 + VSAO:0000031 + XAO:0000168 + musculo-skeletal system + uberon + UBERON:0002204 + + musculoskeletal system + + + + + + + + + + + check ctenophore + + + + + Anatomical system that consists of the muscular and skeletal systems. + + VSAO:0000031 + VSAO:curator + + + + + Anatomical system that provides locomotion and physical support to the organism.[AAO] + 2012-06-20 + AAO:0010546 + AAO + AAO:EJS + + + + + There are more than 50,000 extant vertebrate species, representing over 500 million years of evolution. During that time, the vertebrate musculoskeletal systems have adapted to aquatic, terrestrial, fossorial, and arboreal lifestyles, while simultaneously retaining functionally integrated axial and appendicular skeletal systems.[well established][VHOG] + 2012-09-17 + VHOG:0001275 + VHOG + + DOI:10.1002/jez.b.21246 Shearman RM, Burke AC, The lateral somitic frontier in ontogeny and phylogeny. Journal of Experimental Zoology (2009) + + + + + UMLS:C0026860 + ncithesaurus:Musculoskeletal_System + + + + + + + + + + + + + + + + + + + + + + + + + + + Joint in which the articulating bones or cartilages are connected by an articular capsule which encloses a synovial membrane and a synovial cavity. Examples: Temporomandibular joint, knee joint.[FMA] + Is a joint that is located at the point of contact of articulating bones allowing movement. The joint has a capsule containing synovial fluid surrounding the articulating bone surfaces.[TAO] + + + AEO:0000183 + CALOHA:TS-2138 + EHDAA2:0003183 + FMA:7501 + MA:0000322 + NCIT:C32461 + OpenCyc:Mx4rv2bBV5wpEbGdrcN5Y29ycA + TAO:0005153 + ZFA:0005153 + galen:SynovialJoint + articulatio synoviale + diarthroses + diarthrosis + diarthrosis joint + uberon + diarthrodial joints + UBERON:0002217 + + + + synovial joint + + + + + Joint in which the articulating bones or cartilages are connected by an articular capsule which encloses a synovial membrane and a synovial cavity. Examples: Temporomandibular joint, knee joint.[FMA] + + FMA:7501 + + + + + Is a joint that is located at the point of contact of articulating bones allowing movement. The joint has a capsule containing synovial fluid surrounding the articulating bone surfaces.[TAO] + 2012-08-14 + TAO:0005153 + TAO + ZFIN:Curator + + + + + diarthroses + ZFA:0005153 + + + + + + diarthrodial joints + ZFA:0005153 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The part of the coelemic cavity lumen that is enclosed by the walls of the thorax. + In many species, the diaphragm separates thoracic and abdominal cavities + + + + EMAPA:36497 + FMA:7565 + GAID:93 + MA:0000032 + MESH:A01.911.800 + NCIT:C12905 + OpenCyc:Mx4rmvyleLfEEduAAAACs6hRXg + OpenCyc:Mx4rvhU_TpwpEbGdrcN5Y29ycA + UMLS:C0230139 + cavitas thoracis + cavity of chest + cavity of thorax + chest cavity + pectoral cavity + space of thoracic compartment + thoracic lumen + uberon + UBERON:0002224 + + + thoracic cavity + http://upload.wikimedia.org/wikipedia/commons/c/ce/Gray846.png + http://upload.wikimedia.org/wikipedia/commons/e/ee/Scheme_body_cavities-en.svg + + + + + The part of the coelemic cavity lumen that is enclosed by the walls of the thorax. + + UBERON:cjm + + + + + UMLS:C0230139 + ncithesaurus:Thoracic_Cavity + + + + + cavitas thoracis + + + + + + + space of thoracic compartment + FMA:7565 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Part of the central nervous system located in the vertebral canal continuous with and caudal to the brain; demarcated from brain by plane of foramen magnum. It is composed of an inner core of gray matter in which nerve cells predominate, and an outer layer of white matter in which myelinated nerve fibers predominate, and surrounds the central canal. (CUMBO) + TODO - add superclass to unify with VNC? + Part of the central nervous system which descends from the hindbrain within the vertebral column.[AAO] + (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...) (reference 1); The neural tube is destined to differentiate into the brain and spinal cord (the central nervous system) (reference 2).[well established][VHOG] + + + + + AAO:0010151 + BAMS:SP + BAMS:Spinal + BIRNLEX:1709 + BM:SpC + BTO:0001279 + CALOHA:TS-0953 + DHBA:12890 + DMBA:17651 + EFO:0000110 + EHDAA2:0001255 + EHDAA:2863 + EMAPA:17577 + EV:0100316 + FMA:7647 + GAID:695 + MA:0000216 + MAT:0000183 + MESH:D013116 + MIAA:0000183 + NCIT:C12464 + OpenCyc:Mx4rvVjjk5wpEbGdrcN5Y29ycA + TAO:0000075 + UMLS:C0037925 + VHOG:0000601 + XAO:0000020 + ZFA:0000075 + http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=22 + uberon + SpC + cerebro-cerebellar fissure + cerebrocerebellar fissure + fissura cerebro-cerebellaris + fissura cerebrocerebellaris + medulla spinalis + spinal cord structure + spinal medulla + UBERON:0002240 + + + + + + + + spinal cord + http://upload.wikimedia.org/wikipedia/commons/5/58/Spinal_cord_direv.svg + + + + + + + + + + + definitional + + + + + + + + + + + definitional + + + + + Part of the central nervous system located in the vertebral canal continuous with and caudal to the brain; demarcated from brain by plane of foramen magnum. It is composed of an inner core of gray matter in which nerve cells predominate, and an outer layer of white matter in which myelinated nerve fibers predominate, and surrounds the central canal. (CUMBO) + BIRNLEX:1709 + + + + + Part of the central nervous system which descends from the hindbrain within the vertebral column.[AAO] + 2012-06-20 + AAO:0010151 + AAO + AAO:BJB + + + + + (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...) (reference 1); The neural tube is destined to differentiate into the brain and spinal cord (the central nervous system) (reference 2).[well established][VHOG] + 2012-09-17 + VHOG:0000601 + VHOG + + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.165 + + + + + UMLS:C0037925 + BIRNLEX:1709 + + + + + UMLS:C0037925 + ncithesaurus:Spinal_Cord + + + + + http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=22 + BIRNLEX:1709 + + + + + SpC + + + + + + cerebro-cerebellar fissure + NeuroNames:22 + + + + + cerebrocerebellar fissure + NeuroNames:22 + + + + + fissura cerebro-cerebellaris + NeuroNames:22 + + + + + + fissura cerebrocerebellaris + NeuroNames:22 + + + + + + medulla spinalis + + + + + + + medulla spinalis + BTO:0001279 + + + + + spinal cord structure + ZFA:0000075 + + + + + spinal medulla + BTO:0001279 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Stalk-like part of the brain that includes amongst its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain[ZFA,MP,generalized]. + Multi-tissue structure that has as its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain.[TAO] + Multi-tissue structure that has as its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain[ZFA,adopted][ZFA:0001707]. + the stalk-like part of the brain that comprises the midbrain (aka mesencephalon), the pons (aka pons Varolii), and the medulla oblongata, and connects the cerebral hemispheres with the cervical spinal cord[MP] + + + + + BAMS:BS + BIRNLEX:1565 + BTO:0000146 + CALOHA:TS-0093 + EFO:0001962 + EMAPA:32678 + EV:0100241 + FMA:79876 + MA:0000169 + MBA:343 + MESH:D001933 + NCIT:C12441 + TAO:0002156 + UMLS:C0006121 + VHOG:0001457 + ZFA:0001707 + http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=236 + brain stem + truncus encephali + uberon + accessory medullary lamina of pallidum + lamella pallidi incompleta + lamina medullaris accessoria + lamina medullaris incompleta pallidi + lamina pallidi incompleta + truncus encephalicus + UBERON:0002298 + + + + + 'brainstem' is a loose term that sometimes refers to the ventral parts o the brain except for any part of the telencephalon - sometimes it includes the diencephalon or subpallial telencephalon structures (ISBN:0471888893). Here we use it in a more restriced sense, to include only the medulla oblongata, pons (when present) and the midbrain tegmentum (following the ZFA definitions). + brainstem + http://upload.wikimedia.org/wikipedia/commons/b/b7/Gray719.png + + + + + Stalk-like part of the brain that includes amongst its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain[ZFA,MP,generalized]. + + ISBN:0471888893 + MP:0005277 + ZFA:0001707 + + + + + Multi-tissue structure that has as its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain.[TAO] + 2012-08-14 + TAO:0002156 + TAO + ISBN:3764351209 + + + + + Multi-tissue structure that has as its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain[ZFA,adopted][ZFA:0001707]. + ZFA:0001707 + + + + + the stalk-like part of the brain that comprises the midbrain (aka mesencephalon), the pons (aka pons Varolii), and the medulla oblongata, and connects the cerebral hemispheres with the cervical spinal cord[MP] + MP:0005277 + + + + + UMLS:C0006121 + BIRNLEX:1565 + + + + + UMLS:C0006121 + ncithesaurus:Brain_Stem + + + + + http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=236 + BIRNLEX:1565 + + + + + brain stem + ABA:BS + + + + + truncus encephali + + + + + + + accessory medullary lamina of pallidum + NeuroNames:236 + + + + + lamella pallidi incompleta + NeuroNames:236 + + + + + + lamina medullaris accessoria + NeuroNames:236 + + + + + + lamina medullaris incompleta pallidi + NeuroNames:236 + + + + + + lamina pallidi incompleta + NeuroNames:236 + + + + + + truncus encephalicus + BTO:0000146 + + + + + + + + + + + + + + + + + + + + + + + + + + + + One of the layers of the neocortex. + cortical layer + ABA:CTX1-6b + EMAPA:35588 + FMA:83138 + MA:0000186 + layer of neocortex + neocortex layer + uberon + cerebral cortex layer + lamina of neocortex + UBERON:0002301 + layer of neocortex + + + + + One of the layers of the neocortex. + + + + + + layer of neocortex + FMA:83138 + + + + + neocortex layer + MA:0000186 + + + + + cerebral cortex layer + MA:0000186 + + + + + lamina of neocortex + FMA:83138 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + the atrial part of middle layer of the heart, comprised of involuntary muscle + As noted, the hearts of birds and mammals have four chambers that arises from the two chambers (atrium and ventricle) of the fish heart.[uncertain][VHOG] + + EFO:0003087 + EMAPA:32746 + FMA:83509 + MA:0000081 + TAO:0001374 + VHOG:0000602 + ZFA:0001374 + atrial myocardium + atrium myocardium + uberon + atrium cardiac muscle + UBERON:0002302 + + + + myocardium of atrium + + + + + the atrial part of middle layer of the heart, comprised of involuntary muscle + ISBN:0-683-40008-8 + MP:0010493 + + + + + As noted, the hearts of birds and mammals have four chambers that arises from the two chambers (atrium and ventricle) of the fish heart.[uncertain][VHOG] + 2012-09-17 + VHOG:0000602 + VHOG + + ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.481 + + + + + atrial myocardium + ZFA:0001374 + + + + + atrium cardiac muscle + VHOG:0000602 + + + + + + + + + + + + + + + + + + + + + + + + + + A neural nucleus that is part of the brain. + + + EMAPA:35185 + FMA:83840 + MA:0000811 + NCIT:C49346 + UMLS:C1706993 + ZFA:0005575 + brain nucleus + uberon + brain nuclei + UBERON:0002308 + nucleus of brain + + + + + A neural nucleus that is part of the brain. + + + + + + UMLS:C1706993 + ncithesaurus:Brain_Nucleus + + + + + brain nuclei + ZFA:0005575 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The ridge-shaped grey matter of the spinal cord that extends longitudunally through the center of each half of the spinal cord, and are largely or entirely composed of nerve cell bodies and their dendrites and some supportive tissue. + + + + BAMS:Scgrey + DHBA:146035048 + EMAPA:35792 + FMA:256580 + MA:0000002 + NCIT:C32696 + NLXANAT:100204 + UMLS:C0475853 + gray matter of spinal cord + gray substance of spinal cord + grey matter of spinal cord + grey substance of spinal cord + spinal cord gray matter + spinal cord grey matter + spinal cord grey substance + substantia grisea medullae spinalis + uberon + UBERON:0002315 + + gray matter of spinal cord + + + + + The ridge-shaped grey matter of the spinal cord that extends longitudunally through the center of each half of the spinal cord, and are largely or entirely composed of nerve cell bodies and their dendrites and some supportive tissue. + MP:0008503 + + + + + UMLS:C0475853 + ncithesaurus:Gray_Matter_of_the_Spinal_Cord + + + + + gray matter of spinal cord + OBOL:automatic + + + + + gray substance of spinal cord + FMA:256580 + + + + + spinal cord gray matter + OBOL:automatic + + + + + spinal cord grey substance + OBOL:automatic + + + + + substantia grisea medullae spinalis + FMA:256580 + FMA:TA + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The cavity within the body of all animals higher than the coelenterates and certain primitive worms, formed by the splitting of the embryonic mesoderm into two layers. In mammals it forms the peritoneal, pleural, and pericardial cavities. + check the FMA placement here; ncit placement of body cavity here probably not correct + Anatomical space, part of the trunk that contains the pericardial and pleuroperitoneal cavities[ZFA]. + The cavity within the body of all animals higher than the coelenterates and certain primitive worms, formed by the splitting of the embryonic mesoderm into two layers. In mammals it forms the peritoneal, pleural, and pericardial cavities[BTO]. + In mammals it forms the peritoneal, pleural, and pericardial cavities + UBERON:0000169 + body cavity + + + AEO:0000186 + BTO:0001707 + EHDAA2:0000267 + FBbt:00005060 + FMA:85006 + NCIT:C25444 + RETIRED_EHDAA2:0003186 + TAO:0001438 + UMLS:C0333343 + ZFA:0001438 + galen:BodyCavity + coelomic cavity + coelomic cavity lumen + main body cavity + space of body compartment + ventral body cavity + uberon + celom + coelom + coelome + hemocoel + UBERON:0002323 + + + coelemic cavity lumen + + + + + + + + + + + definitional + + + + + The cavity within the body of all animals higher than the coelenterates and certain primitive worms, formed by the splitting of the embryonic mesoderm into two layers. In mammals it forms the peritoneal, pleural, and pericardial cavities. + BTO:0001707 + + + + + Anatomical space, part of the trunk that contains the pericardial and pleuroperitoneal cavities[ZFA]. + 2012-09-12 + ZFA:0001438 + ZFA + ZFIN:curator + + + + + The cavity within the body of all animals higher than the coelenterates and certain primitive worms, formed by the splitting of the embryonic mesoderm into two layers. In mammals it forms the peritoneal, pleural, and pericardial cavities[BTO]. + 2012-09-12 + BTO:0001707 + BTO + BTO + + + + + body cavity + BTO:0001707 + + + + + UMLS:C0333343 + ncithesaurus:Cavity + + + + + coelomic cavity + EHDAA2:0000267 + + + + + coelomic cavity lumen + EHDAA2:0000267 + + + + + space of body compartment + FMA:85006 + + + + + ventral body cavity + NCBITaxon:7742 + + + + + celom + BTO:0001707 + + + + + coelome + BTO:0001707 + + + + + hemocoel + FBbt:00005060 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A flexible rod-shaped body found in embryos of all chordates. It is composed of cells derived from the mesoderm and defines the primitive axis of the embryo. In some chordates, it persists throughout life as the main axial support of the body, while in most vertebrates it becomes the nucleus pulposus of the intervertebral disc. The notochord is found ventral to the neural tube. + Avascular multi-tissue structure composed of large vacuolated epithelial cells (chordablasts) and perichordal fibrous tissue.[VSAO] + Rod-like principal supportive element of the embryo and larva, present in the midline just ventral to the neural tube, and differentiating during the segmentation period to form large vacuolated epithelial cells and a surrounding a sheath of fibrous and elastic layers. Layering of the sheath may differ in structure, thickness and development among groups; in cypriniforms there are actually three very thin layers to the sheath. A functional, well developed notochord is present throughout life in certain basal fish groups but not in cypriniforms. Kimmel et al, 1995.[TAO] + Slender rod of fibrous connective tissue surrounding a core of fluid-filled cells of mesodermal origin; it lies above the gut and directly beneath the spinal cord. The notochord is present during early development and in a few cases it is retained through life; however, usually the notochord is replaced by the vertebral column.[AAO] + relationship type change: differentiates_from mesoderm (AAO:0000304) CHANGED TO: develops_from mesoderm (UBERON:0000926)[AAO] + (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (3) a stiff, longitudinal rod of turgid cells along the dorsal part of the body that is called a notochord (...).[well established][VHOG] + notochordal + In between vertebra the notochord becomes the nucleus pulposus, under it degenerates, and at anterior end in some species its tissue merges with some of the cranial bones.. Some organisms retain a post-embryonic notochord. + + + + + + + AAO:0000327 + BTO:0001768 + CALOHA:TS-0690 + EHDAA2:0001277 + EHDAA:1241 + EHDAA:6021 + EMAPA:16191 + EV:0100002 + FMA:85521 + GAID:1311 + MAT:0000281 + MESH:A16.254.610 + NCIT:C12463 + TAO:0000135 + UMLS:C0028439 + VHOG:0000199 + VSAO:0000032 + XAO:0000055 + ZFA:0000135 + embryonic notocord + notocord + uberon + notochorda + UBERON:0002328 + + + + The notochord appears early in embryogeny and plays an important role in promoting or organizing the embryonic development of nearby structures. In most adult chordates the notochord disappears or becomes highly modified. In some non-vertebrate chordates and fishes the notochord persists as a laterally flexible but incompressible skeletal rod that prevents telescopic collapse of the body during swimming[TOLWEB] + notochord + http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png + + + + + + VSAO + + + + + + + + + + + ZFA + + + + + + + + + + + EHDAA2 + + + + + A flexible rod-shaped body found in embryos of all chordates. It is composed of cells derived from the mesoderm and defines the primitive axis of the embryo. In some chordates, it persists throughout life as the main axial support of the body, while in most vertebrates it becomes the nucleus pulposus of the intervertebral disc. The notochord is found ventral to the neural tube. + + + + + ISBN:0815318960 + + + + + Avascular multi-tissue structure composed of large vacuolated epithelial cells (chordablasts) and perichordal fibrous tissue.[VSAO] + 2012-08-14 + VSAO:0000032 + VSAO + PSPUB:0000170 + + + + + Rod-like principal supportive element of the embryo and larva, present in the midline just ventral to the neural tube, and differentiating during the segmentation period to form large vacuolated epithelial cells and a surrounding a sheath of fibrous and elastic layers. Layering of the sheath may differ in structure, thickness and development among groups; in cypriniforms there are actually three very thin layers to the sheath. A functional, well developed notochord is present throughout life in certain basal fish groups but not in cypriniforms. Kimmel et al, 1995.[TAO] + 2012-08-14 + TAO:0000135 + TAO + ZFIN:curator + + + + + Slender rod of fibrous connective tissue surrounding a core of fluid-filled cells of mesodermal origin; it lies above the gut and directly beneath the spinal cord. The notochord is present during early development and in a few cases it is retained through life; however, usually the notochord is replaced by the vertebral column.[AAO] + 2012-06-20 + AAO:0000327 + AAO + AAO:LAP + + + + + relationship type change: differentiates_from mesoderm (AAO:0000304) CHANGED TO: develops_from mesoderm (UBERON:0000926)[AAO] + 2012-06-20 + AAO:0000327 + AAO + + + + + (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (3) a stiff, longitudinal rod of turgid cells along the dorsal part of the body that is called a notochord (...).[well established][VHOG] + 2012-09-17 + VHOG:0000199 + VHOG + + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28 + + + + + UMLS:C0028439 + ncithesaurus:Notochord + + + + + notocord + ZFA:0000135 + + + + + notochorda + + + + + + + + + + + + + + + + + + + Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm. + currently classified as an epithelial vesicle, consistent with EHDAA2 and https://github.com/obophenotype/uberon/wiki/The-neural-crest. Consider making 'somitic mesoderm' a separate term and correlate with regionalization processes. Consider moving ZFA term to 'trunk somite' as it is part of the trunk + Post-cranial axial segments which form sclerotome and dermomyotome.[AAO] + Undifferentiated mesodermal components of early trunk or tail segments or metameres, derived from paraxial mesoderm; forms myotomes, sclerotomes and perhaps dermatomes. Kimmel et al, 1995.[TAO] + relationship loss: develops_from paraxial mesenchyme (TAO:0000942)[TAO] + relationship type change: OBO_REL:part_of trunk (TAO:0001115) CHANGED TO: develops_from trunk (UBERON:0002100)[TAO] + relationship type change: part_of paraxial mesoderm (AAO:0010568) CHANGED TO: develops_from paraxial mesoderm (UBERON:0003077)[AAO] + (...) cephalocordates and craniates belong to a group known as Somitichordata. Somitichordate synapomorphies include (1) somites (...) (reference 1); The idea that the last common ancestor of bilaterian animals (Urbilateria) was segmented has been raised recently on evidence coming from comparative molecular embryology (reference 2).[well established][VHOG] + somitic + mesodermal cluster + + + AAO:0010569 + AEO:0001015 + BTO:0001558 + EHDAA2:0003436 + EHDAA:366 + EHDAA:699 + EMAPA:31169 + FMA:85522 + GAID:1306 + MAT:0000068 + MESH:A16.254.425.660.750 + MIAA:0000068 + NCIT:C34302 + TAO:0000155 + UMLS:C0376449 + VHOG:0000191 + XAO:0000058 + ZFA:0000155 + uberon + epimere + epimere mesoderm + epithelial somite + somites + somitic mesoderm + somitus + UBERON:0002329 + + + + When the somite becomes segmented from the segmental plate, it is composed of an epithelial sac enclosing mesenchymal somitocoel cells. Thereafter the somite differentiates into two parts, the ventro-medial mesenchymal sclerotome and the dorso-lateral epithelial dermomyotome. This change in the epithelial somite depends on surrounding tissue [PMID:15906248] + somite + http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png + + + + + + EHDAA2 + + + + + + + + + + + ZFA + + + + + Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm. + + + + + + + Post-cranial axial segments which form sclerotome and dermomyotome.[AAO] + 2012-06-20 + AAO:0010569 + AAO + AAO:EJS + + + + + Undifferentiated mesodermal components of early trunk or tail segments or metameres, derived from paraxial mesoderm; forms myotomes, sclerotomes and perhaps dermatomes. Kimmel et al, 1995.[TAO] + 2012-08-14 + TAO:0000155 + TAO + ZFIN:curator + + + + + relationship loss: develops_from paraxial mesenchyme (TAO:0000942)[TAO] + 2012-08-14 + TAO:0000155 + TAO + + + + + relationship type change: OBO_REL:part_of trunk (TAO:0001115) CHANGED TO: develops_from trunk (UBERON:0002100)[TAO] + 2012-08-14 + TAO:0000155 + TAO + + + + + relationship type change: part_of paraxial mesoderm (AAO:0010568) CHANGED TO: develops_from paraxial mesoderm (UBERON:0003077)[AAO] + 2012-06-20 + AAO:0010569 + AAO + + + + + (...) cephalocordates and craniates belong to a group known as Somitichordata. Somitichordate synapomorphies include (1) somites (...) (reference 1); The idea that the last common ancestor of bilaterian animals (Urbilateria) was segmented has been raised recently on evidence coming from comparative molecular embryology (reference 2).[well established][VHOG] + 2012-09-17 + VHOG:0000191 + VHOG + + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.40, DOI:10.1093/icb/43.1.137 Balavoine G, Adoutte A, The segmented urbilateria: a testable scenario. Integrative and Comparative Biology (2003) + + + + + mesodermal cluster + GO:0001756 + + + + + UMLS:C0376449 + ncithesaurus:Somite + + + + + epimere + ISBN:0073040584 + + + + + epithelial somite + + + + + + somites + + + + + + somitus + + + + + + + + + + + + + + + + + + + + + + + + + + Anatomical system that consists of the glands and parts of glands that produce exocrine secretions and help to integrate and control bodily metabolic activity. Exocrine glands are glands that secrete their products (hormones) into ducts (duct glands). They are the counterparts to endocrine glands, which secrete their products (hormones) directly into the bloodstream (ductless glands) or release hormones (paracrines) that affect only target cells nearby the release site. [Wikipedia]. + + + CALOHA:TS-2057 + EHDAA2:0002225 + EMAPA:35329 + FMA:85539 + MA:0002411 + NCIT:C12957 + UMLS:C1516995 + WikipediaCategory:Exocrine_system + exocrine glandular system + uberon + UBERON:0002330 + + + exocrine system + + + + + Anatomical system that consists of the glands and parts of glands that produce exocrine secretions and help to integrate and control bodily metabolic activity. Exocrine glands are glands that secrete their products (hormones) into ducts (duct glands). They are the counterparts to endocrine glands, which secrete their products (hormones) directly into the bloodstream (ductless glands) or release hormones (paracrines) that affect only target cells nearby the release site. [Wikipedia]. + + + + + + UMLS:C1516995 + ncithesaurus:Exocrine_System + + + + + exocrine glandular system + EHDAA2:0002225 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP]. + consider including subclasses for pre- and post- migratory (e.g. sheets/paths/streams). + + A cell population arising from the dorsolateral aspect of the central nervous system primordium during the segmentation period, and later migrating along stereotyped pathways to give rise to a diverse and well-defined set of cell types including pigment cells, peripheral neurons and glia, and head cartilage. Kimmel et al, 1995.[TAO] + Migratory cell population which delaminates from neural tube, borders surface ectoderm and neural ectoderm, and gives rise to many different tissue types.[AAO] + A well developed neural crest population is present in lampreys (Horigome et al. 1999 ; Tomsa & Langeland, 1999) and gnathostomes. chordate fossils from the early Cambrian (Yunnanozoan and Haikouella) with apparent neural-crest derived structures (pharyngeal denticles and pharyngeal skeletons resembling the striped mucocartilage of the branchial bars in lamprey ammocoete larvae), suggests that neural crest arose very early in vertebrate evolution (Chen et al. 1999; Holland & Chen, 2001). The invertebrate chordates apparently lack defini- tive neural crest. One marker of migrating neural crest in some vertebrates, the antibody HNK1, does not recognize any cells in amphioxus embryos (Holland, unpublished). Even so, in both amphioxus and tunicates, cells at the edges of the neural plate and adjacent nonneural ectoderm share some properties of neural crest[PMID:11523831] + We conclude that the neural crest is a vertebrate novelty, but that neural crest cells and their derivatives evolved and diversified in a step-wise fashion - first by elaboration of neural plate border cells, then by the innovation or co-option of new or ancient metazoan cell fates.[well established][VHOG] + + + + + AAO:0010578 + BTO:0001764 + CALOHA:TS-0676 + EHDAA2:0004419 + EMAPA:32737 + FMA:86666 + GAID:1310 + MAT:0000066 + MESH:A16.254.600 + MIAA:0000066 + NCIT:C34222 + TAO:0000045 + UMLS:C0027789 + VHOG:0000057 + XAO:0000048 + ZFA:0000045 + NC + uberon + crista neuralis + neural crest material + UBERON:0002342 + + + + Gene notes: Many factors and genes, such as Pax3 (Tremblay et al., 1995), slug (Nieto et al., 1994), AP-2 (Zhang et al., 1996; Schorle et al., 1996), and Wnt-1/3a (Ikeya et al., 1997) are expressed in the dorsal most region of the neural tube, and have been shown to be involved in the generation of neural crest cells. + neural crest + Neural:Crest.png + http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray644.png + + + + + + + + + + + + XAO + + + + + + + + + + + BTO + + + + + + + + + + + + + + + + + + + + + + + + + + + A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP]. + MP:0009846 + + + + + + + ISBN:0073040584 + + + + + A cell population arising from the dorsolateral aspect of the central nervous system primordium during the segmentation period, and later migrating along stereotyped pathways to give rise to a diverse and well-defined set of cell types including pigment cells, peripheral neurons and glia, and head cartilage. Kimmel et al, 1995.[TAO] + 2012-08-14 + TAO:0000045 + TAO + ZFIN:curator + + + + + Migratory cell population which delaminates from neural tube, borders surface ectoderm and neural ectoderm, and gives rise to many different tissue types.[AAO] + 2012-06-20 + AAO:0010578 + AAO + AAO:EJS + + + + + A well developed neural crest population is present in lampreys (Horigome et al. 1999 ; Tomsa & Langeland, 1999) and gnathostomes. chordate fossils from the early Cambrian (Yunnanozoan and Haikouella) with apparent neural-crest derived structures (pharyngeal denticles and pharyngeal skeletons resembling the striped mucocartilage of the branchial bars in lamprey ammocoete larvae), suggests that neural crest arose very early in vertebrate evolution (Chen et al. 1999; Holland & Chen, 2001). The invertebrate chordates apparently lack defini- tive neural crest. One marker of migrating neural crest in some vertebrates, the antibody HNK1, does not recognize any cells in amphioxus embryos (Holland, unpublished). Even so, in both amphioxus and tunicates, cells at the edges of the neural plate and adjacent nonneural ectoderm share some properties of neural crest[PMID:11523831] + + + + + + We conclude that the neural crest is a vertebrate novelty, but that neural crest cells and their derivatives evolved and diversified in a step-wise fashion - first by elaboration of neural plate border cells, then by the innovation or co-option of new or ancient metazoan cell fates.[well established][VHOG] + 2012-09-17 + VHOG:0000057 + VHOG + + DOI:10.1111/j.1469-7580.2012.01495.x Hall BK, Gillis JA, Incremental evolution of the neural crest, neural crest cells and neural crest-derived skeletal tissues. J Anat (2012) + + + + + UMLS:C0027789 + ncithesaurus:Neural_Crest + + + + + NC + XAO:0000048 + + + + + + crista neuralis + + + + + + + neural crest material + VHOG:0000057 + + + + + + + + + + Embryonic ectoderm that gives rise to nervous tissue. + (...) the ability of ectoderm to produce neuronal cells is a general metazoan feature.[well established][VHOG] + neurectodermal + we prefer neurectoderm to neural ectoderm since placodal ectoderm is not classified here + + + AAO:0011074 + BILA:0000039 + CALOHA:TS-1212 + EHDAA2:0001248 + EHDAA:1498 + EHDAA:255 + EMAPA:16073 + EV:0100004 + FBbt:00001061 + FMA:87657 + MAT:0000176 + MIAA:0000176 + NCIT:C34228 + TAO:0001120 + UMLS:C1518271 + VHOG:0000150 + XAO:0000042 + ZFA:0001120 + neural ectoderm + neuroectoderm + uberon + epithelium tubi neuralis; neuroectoderma + neuaral ectoderm + presumptive central nervous system + ventral neurogenic region + UBERON:0002346 + + + neurectoderm + + + + + Embryonic ectoderm that gives rise to nervous tissue. + + + + + + (...) the ability of ectoderm to produce neuronal cells is a general metazoan feature.[well established][VHOG] + 2012-09-17 + VHOG:0000150 + VHOG + + DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) + + + + + UMLS:C1518271 + ncithesaurus:Neuroectoderm + + + + + epithelium tubi neuralis; neuroectoderma + + + + + + + ventral neurogenic region + VHOG:0000150 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + a region of the serous membrane that forms the innermost layer of the pericardium and the outer surface of the heart. + TODO - check links with UBERON:0002425 visceral serous pericardium. develops from proepicardium. WP:Epicardium -- When considered as a part of the pericardium, it is the inner layer, or visceral pericardium, continuous with the serous layer. + External layer of the heart.[TAO] + The inner layer of the pericardium that is in contact with the surface of the heart.[AAO] + The visceral pericardium apparently produces the pericardial fluid, which lubricates motion between the inner and outer layers of the pericardium. During ventricular contraction, the wave of depolarization moves from endocardial to epicardial surface. [Wikipedia:Epicardium] + + + AAO:0010409 + EHDAA2:0002202 + FMA:9461 + NCIT:C13164 + TAO:0005057 + UMLS:C0225968 + VHOG:0000119 + XAO:0000316 + ZFA:0005057 + galen:Epicardium + heart epicardium + visceral serous pericardium of heart + visceral serous pericardium proper + uberon + pericardium visceral mesothelium + UBERON:0002348 + + + + epicardium + + + + + + + + + + + multiple + + + + + + + + + + + FMA-inferred + + + + + + + + + + + FMA + + + + + a region of the serous membrane that forms the innermost layer of the pericardium and the outer surface of the heart. + + + + + + External layer of the heart.[TAO] + 2012-08-14 + TAO:0005057 + TAO + ZFIN:curator + + + + + The inner layer of the pericardium that is in contact with the surface of the heart.[AAO] + 2012-06-20 + AAO:0010409 + AAO + AAO:BJB + + + + + UMLS:C0225968 + ncithesaurus:Epicardium + + + + + visceral serous pericardium of heart + FMA:9461 + + + + + visceral serous pericardium proper + FMA:9461 + + + + + pericardium visceral mesothelium + EMAPA:16589 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + the middle layer of the heart, comprised mainly of striated cardiac muscle fibers + TODO - check 'Myocardum proper' in FMA. We superclass the more generic class for now. FMA has is_a muscle layer - should we add this? ZFA and BTO both have is_a 'cardiac muscle' (tissue?). But in U we also follow FMA and have cardiac muscle tissue of myocardium (there is also Fibrocollagenous connective tissue of myocardium), which would be identical (see issue-10). Note that GO also treats left/right ventricular cardiac muscle tissue synonymous with ventricular myocardium + Robust muscular tunic of the heart which forms the basic part of its walls. Its external surface is covered by the pericardium and its internal one by the endocardium. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG] + The middle layer of the heart, consisting of cardiac muscle.[AAO] + myocardial + + + + AAO:0010410 + BSA:0000089 + BTO:0000901 + CALOHA:TS-0440 + EFO:0000819 + EHDAA2:0004150 + EMAPA:32688 + EV:0100022 + FMA:9462 + GAID:173 + MA:0000164 + MAT:0000453 + MESH:D009206 + NCIT:C12371 + OpenCyc:Mx4ro36AFrCvEduAAAAOpmP6tw + RETIRED_EHDAA2:0001220 + TAO:0001319 + UMLS:C0027061 + VHOG:0000083 + XAO:0000065 + ZFA:0001319 + galen:Myocardium + heart myocardium + muscle of heart + uberon + cardiac muscle + heart muscle + UBERON:0002349 + + + + + myocardium + http://upload.wikimedia.org/wikipedia/commons/6/6e/Glanzstreifen.jpg + + + + + the middle layer of the heart, comprised mainly of striated cardiac muscle fibers + ISBN:0-683-40008-8 + MP:0005329 + + + + + Robust muscular tunic of the heart which forms the basic part of its walls. Its external surface is covered by the pericardium and its internal one by the endocardium. [Dorian_AF, Elsevier's_encyclopaedic_dictionary_of_medicine, Part_B:_Anatomy_(1988)_Amsterdam_etc.:_Elsevier][VHOG] + 2012-09-17 + VHOG:0000083 + VHOG + + + + + + The middle layer of the heart, consisting of cardiac muscle.[AAO] + 2012-06-20 + AAO:0010410 + AAO + AAO:BJB + + + + + UMLS:C0027061 + ncithesaurus:Myocardium + + + + + muscle of heart + FMA:9462 + + + + + cardiac muscle + ZFA:0001319 + + + + + heart muscle + FMA:9462 + + + + + heart muscle + ZFA:0001319 + + + + + + + + + + + + + + + + The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat[GO] + EHDAA2 divides the system from the tissue + The fish heart displays clear polarity of contraction in a posterior-to-anterior direction. The contraction waves originate in the sinus venosus and terminate in the conus arteriosus. The nodal phenotype persists in the inflow region of the heart, varying from the venosinus to the sinoatrial junctional areas in different species . Similar to the mammalian situation, pacemaker tissue with a lower intrinsic rhythmicity is also found at the atrioventricular junction.[uncertain][VHOG] + + EFO:0003909 + EHDAA2:0004185 + EMAPA:35428 + EV:0100025 + FMA:9476 + MA:0000094 + MESH:D006329 + TAO:0005063 + VHOG:0001271 + ZFA:0005063 + cardiac conducting system + cardiac conduction system + cardiac impulse conducting system + cardionector + complexus stimulans cordis + heart conduction system + impulse conducting system + systema conducente cordis + uberon + central conduction system + UBERON:0002350 + + + + conducting system of heart + + + + + + FMA + + + + + The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat[GO] + GO:0003161 + + + + + The fish heart displays clear polarity of contraction in a posterior-to-anterior direction. The contraction waves originate in the sinus venosus and terminate in the conus arteriosus. The nodal phenotype persists in the inflow region of the heart, varying from the venosinus to the sinoatrial junctional areas in different species . Similar to the mammalian situation, pacemaker tissue with a lower intrinsic rhythmicity is also found at the atrioventricular junction.[uncertain][VHOG] + 2012-09-17 + VHOG:0001271 + VHOG + + DOI:10.1152/physrev.00006.2003 Moorman AFM, Christoffels VM, Cardiac Chamber Formation: Development, Genes, and Evolution. Physiological Reviews (2003) + + + + + cardiac conducting system + VHOG:0001271 + + + + + cardiac impulse conducting system + GO:0003161 + + + + + complexus stimulans cordis + FMA:9476 + FMA:TA + + + + + + heart conduction system + GO:0003161 + + + + + impulse conducting system + MA:0000094 + + + + + systema conducente cordis + FMA:9476 + FMA:TA + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Serous membrane which is divided into parietal and visceral serous pericardium. + + + EMAPA:19030 + FMA:9582 + MA:0002739 + serous portion of pericardium + uberon + pericardium serosum + UBERON:0002357 + + serous pericardium + + + + + + + + + + + FMA + + + + + + + + + + + FMA + + + + + Serous membrane which is divided into parietal and visceral serous pericardium. + + + + + + + serous portion of pericardium + FMA:9582 + + + + + pericardium serosum + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Membrane organ which is attached to the pericardial sac proper and the central tendon of diaphragm and is continuous with the pretracheal fascia.[FMA] + most superficial part of pericardium; continuous with the outer adventitial layer of the neighboring great blood vessels. [Wikipedia:Pericardium] + + + EMAPA:19029 + FMA:9586 + MA:0002738 + fibrous portion of pericardium + uberon + pericardium fibrosum + UBERON:0002359 + + + fibrous pericardium + + + + + + FMA + + + + + + + + + + + FMA + + + + + + + + + + + WP + + + + + Membrane organ which is attached to the pericardial sac proper and the central tendon of diaphragm and is continuous with the pretracheal fascia.[FMA] + FMA:9586 + + + + + pericardium fibrosum + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A gland that secretes products (excluding hormones and other chemical messengers) into ducts (duct glands) which lead directly into the external environment[WP]. Typical exocrine glands include sweat glands, salivary glands, mammary glands, stomach, liver, pancreas + Currently this is logically defined by the system it belongs to, but a better system may be base this on presence/absence of ducts. However, the dual nature of the liver should be taken into consideration here. Consider adding subclasses + + + + AEO:0000097 + BTO:0000765 + CALOHA:TS-2012 + EHDAA2:0003097 + EMAPA:35327 + FMA:9596 + GAID:34 + MA:0002564 + MESH:D005088 + NCIT:C12712 + UMLS:C0015282 + ducted gland + glandula exocrina + uberon + UBERON:0002365 + + + + exocrine gland + + + + + A gland that secretes products (excluding hormones and other chemical messengers) into ducts (duct glands) which lead directly into the external environment[WP]. Typical exocrine glands include sweat glands, salivary glands, mammary glands, stomach, liver, pancreas + + + + + + UMLS:C0015282 + ncithesaurus:Exocrine_Gland + + + + + ducted gland + AEO:0000097 + + + + + glandula exocrina + + + + + + + + + + + Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance. + One of the four types of tissue in traditional classifications. It is largely a category of exclusion rather than one with a precise definition, but there are certain characteristics shared by all or most tissues in this category, such as involvement in structure and support, derived from mesoderm, and characterized largely by the traits of non-living tissue.[AAO] + Portion of tissue that consists of mesodermally derived cells and intercellular matrix comprised of protein fibers and carbohydrates, which supports, ensheathes and binds together other tissues.[TAO] + Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance.[VSAO] + MA also has set of connective tissues + + + + + AAO:0000098 + BTO:0000421 + CALOHA:TS-2009 + EFO:0000952 + EMAPA:35251 + FMA:9640 + GAID:100 + MA:0000011 + MAT:0000301 + MESH:D003238 + MIAA:0000301 + NCIT:C12374 + OpenCyc:Mx4rv-aBgZwpEbGdrcN5Y29ycA + TAO:0001641 + UMLS:C0009780 + VSAO:0000017 + XAO:0001017 + ZFA:0001632 + galen:ConnectiveTissue + portion of connective tissue + textus connectivus + uberon + Bindegewebe + UBERON:0002384 + + + + connective tissue + + + + + Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance. + + + GO_REF:0000034 + PSPUB:0000170 + VSAO:0000017 + + + + + One of the four types of tissue in traditional classifications. It is largely a category of exclusion rather than one with a precise definition, but there are certain characteristics shared by all or most tissues in this category, such as involvement in structure and support, derived from mesoderm, and characterized largely by the traits of non-living tissue.[AAO] + 2012-06-20 + AAO:0000098 + AAO + AAO:LAP + + + + + Portion of tissue that consists of mesodermally derived cells and intercellular matrix comprised of protein fibers and carbohydrates, which supports, ensheathes and binds together other tissues.[TAO] + 2012-08-14 + TAO:0001641 + TAO + TAO:wd + + + + + Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance.[VSAO] + 2012-08-14 + VSAO:0000017 + VSAO + GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 + PSPUB:0000170 + + + + + MA also has set of connective tissues + MA + + + + + UMLS:C0009780 + ncithesaurus:Connective_Tissue + + + + + portion of connective tissue + FMA:9640 + + + + + Bindegewebe + BTO:0000421 + + + + + + + + + + + + + + + + + Muscle tissue is a contractile tissue made up of actin and myosin fibers[GO]. + One of the four types of tissue in traditional classifications. Tissue that contains cells with contractile filaments that move past each other and change the size of the cell. Muscle tissue also is separated into three distinct categories.[AAO] + + + + AAO:0000306 + AEO:0000122 + CALOHA:TS-0642 + EHDAA2:0003122 + EMAPA:32715 + FMA:9641 + MA:0002437 + MESH:D009132 + NCIT:C12435 + UMLS:C2328219 + galen:MuscleTissue + muscular tissue + portion of muscle tissue + textus muscularis + uberon + UBERON:0002385 + + Vertebrate muscle is categorized into three major muscle types defined by their structural and functional properties: skeletal, cardiac and smooth. In Dmel the counterparts are somatic, heart/cardiac and visceral. Here we take a cell type based approach. + muscle tissue + + + + + Muscle tissue is a contractile tissue made up of actin and myosin fibers[GO]. + + + GO:0060537 + + + + + One of the four types of tissue in traditional classifications. Tissue that contains cells with contractile filaments that move past each other and change the size of the cell. Muscle tissue also is separated into three distinct categories.[AAO] + 2012-06-20 + AAO:0000306 + AAO + AAO:LAP + + + + + UMLS:C2328219 + ncithesaurus:Muscle_Tissue + + + + + muscular tissue + + + + + + portion of muscle tissue + FMA:9641 + + + + + + + + + + + + + + + + + + + + + + + + Anatomical system that is involved in the production of hematopoietic cells. + Anatomical system that consists of the blood and blood forming tissues.[AAO] + Zebrafish developmental hematopoiesis shows close correspondence to the development of the mammalian hematopoietic system and is regulated by conserved molecular pathways.[well established][VHOG] + hematopoietic + In humans this is primarily the bone marrow, spleen, tonsils, and lymph nodes + + + + AAO:0011002 + BTO:0000570 + CALOHA:TS-0449 + EFO:0000798 + EMAPA:35402 + EV:0100045 + FMA:9667 + GAID:1008 + MA:0002434 + MAT:0000022 + MESH:D006413 + MIAA:0000022 + NCIT:C12909 + TAO:0005023 + UMLS:C0018957 + VHOG:0001624 + XAO:0000122 + ZFA:0005023 + haematological system + haemopoietic system + organa haemopoietica + uberon + Blutbildungssystem + haematopoietic system + hematological system + hematolymphoid system + hemopoietic system + UBERON:0002390 + + + + + hematopoietic system + + + + + + + + + + + FMA + + + + + + + + + + + definitional + + + + + Anatomical system that is involved in the production of hematopoietic cells. + + + + + + Anatomical system that consists of the blood and blood forming tissues.[AAO] + 2012-06-20 + AAO:0011002 + AAO + AAO:EJS + + + + + Zebrafish developmental hematopoiesis shows close correspondence to the development of the mammalian hematopoietic system and is regulated by conserved molecular pathways.[well established][VHOG] + 2012-09-17 + VHOG:0001624 + VHOG + + DOI:10.1016/j.coph.2010.05.004 Ellett F, Lieschke GJ, Zebrafish as a model for vertebrate hematopoiesis. Current Opinion in Pharmacology (2010) + + + + + In humans this is primarily the bone marrow, spleen, tonsils, and lymph nodes + WP + + + + + UMLS:C0018957 + ncithesaurus:Hematopoietic_System + + + + + Blutbildungssystem + BTO:0000570 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + a double-walled sac containing the heart and the roots of the great vessels. + + FMA:9868 + RETIRED_EHDAA2:0001443 + TAO:0000054 + uberon + pericardium + UBERON:0002406 + + + pericardial sac + http://upload.wikimedia.org/wikipedia/commons/7/7e/Gray489.png + + + + + + + + + + + FMA + + + + + a double-walled sac containing the heart and the roots of the great vessels. + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The combination of pericardial sac (a double-walled sac containing the heart and the roots of the great vessels) plus fibrous pericardium. + Peritoneum that surrounds the heart.[AAO] + pericardial + In GO the concept of pericardium is developmental implicitly epithelial, but here it represents a multi-tissue structure encompassing the sac (epithelium plus connective) and cavity + this class denotes a combination of fibrous PC + PC sac (itself a combination of cavity, epithelium and connective tissue). Many sources use the term 'pericardium' to denote either just the serous membrane (ZFA) or the epithelium (GO) + we follow FMA in dividing pericardium into pericardial sac and fibrous pericardium + + + + AAO:0010817 + BSA:0000090 + BTO:0000717 + CALOHA:TS-0761 + EFO:0000820 + EHDAA:5376 + EMAPA:16133 + EV:0100023 + FMA:9869 + GAID:569 + MA:0000099 + MAT:0000454 + MESH:D010496 + NCIT:C13005 + OpenCyc:Mx4rvoCLgJwpEbGdrcN5Y29ycA + RETIRED_EHDAA2:0001443 + TAO:0000054 + UMLS:C0031050 + VHOG:0001280 + XAO:0004182 + ZFA:0000054 + galen:Pericardium + uberon + UBERON:0002407 + + + + + pericardium + http://upload.wikimedia.org/wikipedia/commons/7/7e/Gray489.png + + + + + + + + + + + MA + + + + + The combination of pericardial sac (a double-walled sac containing the heart and the roots of the great vessels) plus fibrous pericardium. + + + + + + + Peritoneum that surrounds the heart.[AAO] + 2012-06-20 + AAO:0010817 + AAO + AAO:JMG + + + + + In GO the concept of pericardium is developmental implicitly epithelial, but here it represents a multi-tissue structure encompassing the sac (epithelium plus connective) and cavity + FMA + + + + + this class denotes a combination of fibrous PC + PC sac (itself a combination of cavity, epithelium and connective tissue). Many sources use the term 'pericardium' to denote either just the serous membrane (ZFA) or the epithelium (GO) + ZFA + + + + + we follow FMA in dividing pericardium into pericardial sac and fibrous pericardium + FMA + + + + + UMLS:C0031050 + ncithesaurus:Pericardium + + + + + + + + + + + + + + + + + + + + + + + + + + Parietal serous membrane which is part of the pericardium and forms the outer layer of the pericardial sac. + + + + EHDAA:3422 + EHDAA:5378 + EMAPA:19031 + FMA:9870 + MA:0000483 + NCIT:C94500 + UMLS:C0225969 + VHOG:0000537 + lamina parietalis (pericardii serosum) + lamina parietalis pericardii + parietal layer of serous pericardium + parietal pericardium + uberon + pericardial sac + UBERON:0002408 + + + parietal serous pericardium + http://upload.wikimedia.org/wikipedia/commons/7/7e/Gray489.png + + + + + Parietal serous membrane which is part of the pericardium and forms the outer layer of the pericardial sac. + + + + + + UMLS:C0225969 + ncithesaurus:Parietal_Pericardium + + + + + lamina parietalis pericardii + FMA:9870 + FMA:TA + + + + + + parietal pericardium + VHOG:0000537 + + + + + pericardial sac + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Transudate contained in the pericardial cavity.[FMA] + + BTO:0001016 + FMA:9887 + MA:0002530 + uberon + UBERON:0002409 + + pericardial fluid + + + + + + FMA + + + + + Transudate contained in the pericardial cavity.[FMA] + + FMA:9887 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Connected anatomical system that forms a barrier between an animal and its environment. In vertebrates, the integumental system consists of the epidermis, dermis plus associated glands and adnexa such as hair and scales. In invertebrates, the integumental system may include cuticle. + (...) the integument of many tetrapods is reinforced by a morphologically and structurally diverse assemblage of skeletal elements. These elements are widely understood to be derivatives of the once all-encompassing dermal skeleton of stem-gnathostomes (...).[well established][VHOG] + + + UBERON:0007029 + + + + AEO:0000154 + BILA:0000118 + CALOHA:TS-1299 + CARO:0002001 + EFO:0000807 + EHDAA2:0000836 + EHDAA2_RETIRED:0003154 + EHDAA:6520 + EMAPA:17524 + EV:0100151 + FBbt:00004969 + FMA:72979 + HAO:0000421 + MA:0000014 + MAT:0000033 + MESH:D034582 + MIAA:0000033 + NCIT:C12907 + TADS:0000108 + UMLS:C0037267 + VHOG:0000403 + XAO:0000176 + galen:Surface + integumentary system + uberon + body surface + dermal system + external covering of organism + integumentum commune + organism surface + surface + UBERON:0002416 + + + + integumental system + + + + + Connected anatomical system that forms a barrier between an animal and its environment. In vertebrates, the integumental system consists of the epidermis, dermis plus associated glands and adnexa such as hair and scales. In invertebrates, the integumental system may include cuticle. + + + CARO:0002001 + + + + + (...) the integument of many tetrapods is reinforced by a morphologically and structurally diverse assemblage of skeletal elements. These elements are widely understood to be derivatives of the once all-encompassing dermal skeleton of stem-gnathostomes (...).[well established][VHOG] + 2012-09-17 + VHOG:0000403 + VHOG + + DOI:10.1111/j.1469-7580.2008.01043.x Vickaryous MK, Sire JY, The integumentary skeleton of tetrapods: origin, evolution, and development. J Anat (2009) + + + + + UMLS:C0037267 + ncithesaurus:Integumentary_System + + + + + integumentary system + FMA:72979 + + + + + dermal system + MIAA:0000033 + + + + + integumentum commune + + + + + + + organism surface + EHDAA2:0003154 + + + + + surface + BILA:0000118 + + + + + + + + + + + + + + + + + + + + + + + + + + + + A gland that is part of a skin of body [Automatically generated definition]. + check FMA, use plural for now as general class not there + + EMAPA:35774 + FMA:71878 + MA:0000146 + glandulae cutis + uberon + set of skin glands + skin glands + skin glands set + UBERON:0002419 + + skin gland + + + + + A gland that is part of a skin of body [Automatically generated definition]. + OBOL:automatic + + + + + glandulae cutis + FMA:71878 + FMA:TA + + + + + + set of skin glands + FMA:71878 + + + + + skin glands + + + + + + skin glands set + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of the mouth and lines the oral cavity, typically stratified squamous, and may be para-, ortho- or non- keratinized. Primary barrier between oral environment and deeper tissues + consider including separate class for developmental structure (adult human is stratified; in EHDAA2 is unilaminar) + The epithelium that lines the oral cavity. The oral epithelium epithelial cells with many short microvilli as well as mucous cells, rodlet cells and taste buds[ZFIN:ZDB-PUB-060921-12, ZFIN:ZDB-PUB-091204-24]. + the avian oral epithelium has the developmental capacity to initiate tooth developmental programs with underlying grafts of non-avian oral ectomesenchyme + + AAO:0010357 + BTO:0001775 + CALOHA:TS-0715 + EHDAA2:0001325 + EHDAA:2187 + EMAPA:16839 + EMAPA:26942 + FMA:265152 + MA:0000344 + NCIT:C49595 + TAO:0000816 + UMLS:C1709332 + VHOG:0000187 + XAO:0003201 + ZFA:0000816 + epithelium of mucosa of mouth + epithelium of oral mucosa + uberon + UBERON:0002424 + + oral epithelium + + + + + + + + + + + AAO-modified + + + + + An epithelium that is part of the mouth and lines the oral cavity, typically stratified squamous, and may be para-, ortho- or non- keratinized. Primary barrier between oral environment and deeper tissues + + + + + + The epithelium that lines the oral cavity. The oral epithelium epithelial cells with many short microvilli as well as mucous cells, rodlet cells and taste buds[ZFIN:ZDB-PUB-060921-12, ZFIN:ZDB-PUB-091204-24]. + ZFA:0000816 + + + + + the avian oral epithelium has the developmental capacity to initiate tooth developmental programs with underlying grafts of non-avian oral ectomesenchyme + + + + + + UMLS:C1709332 + ncithesaurus:Oral_Cavity_Epithelium + + + + + epithelium of mucosa of mouth + FMA:265152 + + + + + epithelium of oral mucosa + FMA:265152 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Visceral serous membrane which is continuous with the parietal serous pericardium and is attached to the myocardium[FMA]. + + + EMAPA:16589 + EMAPA:19032 + FMA:84882 + MA:0000484 + VHOG:0000538 + lamina visceralis pericardii serosi + serous visceral pericardium + visceral lamina of serous pericardium + visceral layer of serous pericardium + visceral pericardium + uberon + epicardium + pericardium visceral mesothelium + UBERON:0002425 + + + visceral serous pericardium + + + + + + + + + + + cjm + + + + + + + + + + + FMA + + + + + Visceral serous membrane which is continuous with the parietal serous pericardium and is attached to the myocardium[FMA]. + + + + + + lamina visceralis pericardii serosi + + + + + + + visceral pericardium + VHOG:0000538 + + + + + epicardium + MA:0000484 + + + + + pericardium visceral mesothelium + EMAPA:16589 + + + + + + + + + + + + + + + + + + + + + + + + + + + A blood vessel that is part of a choroid [Automatically generated definition]. + EMAPA:17828 + FMA:76550 + MA:0001237 + blood vessel of choroid + blood vessel of choroid coat + blood vessel of choroidea + blood vessel of posterior uvea + choroid blood vessel + choroid blood vessels + choroid blood vessels set + choroid coat blood vessel + choroidea blood vessel + posterior uvea blood vessel + vasa sanguinea choroideae + uberon + set of choroid blood vessels + UBERON:0002443 + + cannot find singular in FMA, using Set class + choroidal blood vessel + + + + + A blood vessel that is part of a choroid [Automatically generated definition]. + OBOL:automatic + + + + + blood vessel of choroid + OBOL:automatic + + + + + blood vessel of choroid coat + OBOL:automatic + + + + + blood vessel of choroidea + OBOL:automatic + + + + + blood vessel of posterior uvea + OBOL:automatic + + + + + choroid blood vessel + OBOL:automatic + + + + + choroid coat blood vessel + OBOL:automatic + + + + + choroidea blood vessel + OBOL:automatic + + + + + posterior uvea blood vessel + OBOL:automatic + + + + + vasa sanguinea choroideae + FMA:76550 + FMA:TA + + + + + + set of choroid blood vessels + FMA:76550 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of a iris [Automatically generated definition]. + EMAPA:35447 + FMA:58517 + MA:0002826 + epithelial tissue of iris + epithelium of iris + epithelium pigmentosum (iris) + epithelium pigmentosum iridis + iris epithelial tissue + iris epithelium + pigmented epithelium of iris + uberon + iris pigmented epithelium + UBERON:0002506 + + iris epithelium + + + + + + FMA + + + + + + + + + + + MA + + + + + An epithelium that is part of a iris [Automatically generated definition]. + OBOL:automatic + + + + + epithelial tissue of iris + OBOL:automatic + + + + + epithelium of iris + OBOL:automatic + + + + + epithelium pigmentosum (iris) + FMA:58517 + + + + + epithelium pigmentosum iridis + FMA:58517 + FMA:TA + + + + + + iris epithelial tissue + OBOL:automatic + + + + + iris epithelium + FMA:58517 + + + + + pigmented epithelium of iris + FMA:58517 + + + + + iris pigmented epithelium + MA:0002826 + + + + + + + + + Connective tissue composed of elastic fibers. + + + FMA:20113 + GAID:926 + MA:0002853 + MESH:D004547 + NCIT:C32495 + elastic connective tissue + textus connectivus elasticus + elastic fiber + uberon + UBERON:0002521 + + elastic tissue + http://upload.wikimedia.org/wikipedia/commons/c/cb/Gray377.png + + + + + Connective tissue composed of elastic fibers. + + + + + + textus connectivus elasticus + + + + + + + + + + + + + + + + + + + + + + + + + + + + The middle layer of an artery or vein. [WP,unvetted]. + + + + BTO:0002011 + EMAPA:36298 + FMA:55590 + GAID:170 + MA:0002855 + MESH:D017540 + NCIT:C33821 + UMLS:C0162867 + uberon + tunica media vasorum + UBERON:0002522 + + May be composed of smooth muscle and elastic tissue + tunica media + Illu:artery.jpg + + + + + + MA + + + + + + + + + + + cjm + + + + + + + + + + + cjm + + + + + The middle layer of an artery or vein. [WP,unvetted]. + + + + + + UMLS:C0162867 + ncithesaurus:Tunica_Media + + + + + tunica media vasorum + + + + + + + tunica media vasorum + BTO:0002011 + + + + + + + + + + + + + + + + + + + + + + + + + + + + The innermost layer of a blood vessel which is a lining of endothelial cells facing the lumen[Kardong]. + the FMA class represents a more generic layer which is the superclass of the layer found in both blood vessels and lymph vessels (and also endocardium) - we should probably follow this structure + the FMA class represents a structure which may have both epithelium and fibroelastic connective tissue as parts + The tunica intima (or just intima) is the innermost layer of an artery or vein. It is made up of one layer of endothelial cells and is supported by an internal elastic lamina. The endothelial cells are in direct contact with the blood flow. The inner coat (tunica intima) can be separated from the middle by a little maceration, or it may be stripped off in small pieces; but, on account of its friability, it cannot be separated as a complete membrane. It is a fine, transparent, colorless structure which is highly elastic, and, after death, is commonly corrugated into longitudinal wrinkles. The inner coat consists of: A layer of pavement endothelium, the cells of which are polygonal, oval, or fusiform, and have very distinct round or oval nuclei. This endothelium is brought into view most distinctly by staining with silver nitrate. A subendothelial layer, consisting of delicate connective tissue with branched cells lying in the interspaces of the tissue; in arteries of less than 2 mm. in diameter the subendothelial layer consists of a single stratum of stellate cells, and the connective tissue is only largely developed in vessels of a considerable size. An elastic or fenestrated layer, which consists of a membrane containing a net-work of elastic fibers, having principally a longitudinal direction, and in which, under the microscope, small elongated apertures or perforations may be seen, giving it a fenestrated appearance. It was therefore called by Henle the fenestrated membrane. This membrane forms the chief thickness of the inner coat, and can be separated into several layers, some of which present the appearance of a network of longitudinal elastic fibers, and others a more membranous character, marked by pale lines having a longitudinal direction. In minute arteries the fenestrated membrane is a very thin layer; but in the larger arteries, and especially in the aorta, it has a very considerable thickness. [WP,unvetted].[Wikipedia] + + + + + BTO:0002012 + EMAPA:36297 + FMA:55589 + GAID:523 + MA:0002861 + MESH:D017539 + NCIT:C33820 + UMLS:C0162864 + uberon + Bichat's tunic + intima + tunica intima vasorum + UBERON:0002523 + + tunica intima + Illu:artery.jpg + + + + + + FMA + + + + + + + + + + + check for exceptions, e.g. capillaries + + + + + + + + + + + ISBN:0073040584 + + + + + The innermost layer of a blood vessel which is a lining of endothelial cells facing the lumen[Kardong]. + + ISBN:0073040584 + NCIT:C33820 + + + + + The tunica intima (or just intima) is the innermost layer of an artery or vein. It is made up of one layer of endothelial cells and is supported by an internal elastic lamina. The endothelial cells are in direct contact with the blood flow. The inner coat (tunica intima) can be separated from the middle by a little maceration, or it may be stripped off in small pieces; but, on account of its friability, it cannot be separated as a complete membrane. It is a fine, transparent, colorless structure which is highly elastic, and, after death, is commonly corrugated into longitudinal wrinkles. The inner coat consists of: A layer of pavement endothelium, the cells of which are polygonal, oval, or fusiform, and have very distinct round or oval nuclei. This endothelium is brought into view most distinctly by staining with silver nitrate. A subendothelial layer, consisting of delicate connective tissue with branched cells lying in the interspaces of the tissue; in arteries of less than 2 mm. in diameter the subendothelial layer consists of a single stratum of stellate cells, and the connective tissue is only largely developed in vessels of a considerable size. An elastic or fenestrated layer, which consists of a membrane containing a net-work of elastic fibers, having principally a longitudinal direction, and in which, under the microscope, small elongated apertures or perforations may be seen, giving it a fenestrated appearance. It was therefore called by Henle the fenestrated membrane. This membrane forms the chief thickness of the inner coat, and can be separated into several layers, some of which present the appearance of a network of longitudinal elastic fibers, and others a more membranous character, marked by pale lines having a longitudinal direction. In minute arteries the fenestrated membrane is a very thin layer; but in the larger arteries, and especially in the aorta, it has a very considerable thickness. [WP,unvetted].[Wikipedia] + Wikipedia + + + + + + UMLS:C0162864 + ncithesaurus:Tunica_Intima + + + + + Bichat's tunic + BTO:0002012 + + + + + intima + BTO:0002012 + + + + + tunica intima vasorum + BTO:0002012 + + + + + + + + + + + + + + + an organ that functions as a secretory or excretory organ + glandular + UBERON:MIAA_0000021 + + + + AAO:0000212 + AEO:0000096 + BTO:0000522 + EFO:0000797 + EHDAA2:0003096 + EHDAA:2161 + EHDAA:4475 + EHDAA:6522 + EMAPA:18425 + FBbt:00100317 + FMA:7146 + FMA:86294 + HAO:0000375 + MA:0003038 + MAT:0000021 + MIAA:0000021 + NCIT:C13319 + OpenCyc:Mx4rwP3vyJwpEbGdrcN5Y29ycA + UMLS:C1285092 + WikipediaCategory:Glands + galen:Gland + glandular organ + uberon + Druese + glandula + UBERON:0002530 + + + + gland + http://upload.wikimedia.org/wikipedia/commons/a/a1/Gray1026.png + + + + + an organ that functions as a secretory or excretory organ + MGI:csmith + MP:0002163 + + + + + UMLS:C1285092 + ncithesaurus:Gland + + + + + glandular organ + + + + + + Druese + BTO:0000522 + + + + + glandula + + + + + + + glandula + BTO:0000522 + + + + + + + + + In amniote animal embryology, the epiblast is a tissue type derived either from the inner cell mass in mammals or the blastodisc in birds and reptiles. It lies above the hypoblast. In mammalian embryogenesis, the columnar cells of the epiblast are adjacent to the trophoblast, while the cuboidal cells of the hypoblast are closer to the blastocoele. The epiblast, whilst referred to as the primary ectoderm, differentiates to form all three layers of the trilaminar germ disc in a process called gastrulation[WP]. The outer of the two layers of the blastoderm that form during gastrulation, corresponding to primitive ectoderm during gastrulation and to the definitive ectoderm after gastrulation[ZFA] + MP says - tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper. In HOG, epiblast is part of primitive streak/blastpore, which is inconsistent with the MP definition of primitive streak as a ridge of the epiblast. Note that these terms, epiblast and hypoblast, are also used to describe layers of the avian embryonic blastoderm, but the layers so-named seem to be altogether different in these two kinds of vertebrate embryos(CVS). Consider obsoleting this as a grouping class + In pregastrula zebrafish embryos, the epiblast is an inverted cup of cells that sits on top of a large yolk cell. (...) In amniote embryos (mammals and birds), gastrulation initiates in an epithelial layer called the epiblast. Cells in the epiblast undergo an epithelial to mesenchymal transition (EMT), migrate through the primitive streak (PS), and incorporate in the middle (mesoderm) or outer (endoderm) layer. The presumptive definitive endoderm (DE) cells invade and displace an outer layer of extraembryonic tissue cells, the hypoblast in chick and the visceral endoderm (VE) in mouse, which form supporting structures such as the yolk sac.[uncertain][VHOG] + + BTO:0004593 + FMA:296704 + MAT:0000067 + MIAA:0000067 + VHOG:0000243 + epiblast + uberon + blastocyst + ectoblast + epiblastus + primitive ectoderm + UBERON:0002532 + + + + + epiblast (generic) + http://upload.wikimedia.org/wikipedia/commons/e/e3/Gray21.png + + + + + In amniote animal embryology, the epiblast is a tissue type derived either from the inner cell mass in mammals or the blastodisc in birds and reptiles. It lies above the hypoblast. In mammalian embryogenesis, the columnar cells of the epiblast are adjacent to the trophoblast, while the cuboidal cells of the hypoblast are closer to the blastocoele. The epiblast, whilst referred to as the primary ectoderm, differentiates to form all three layers of the trilaminar germ disc in a process called gastrulation[WP]. The outer of the two layers of the blastoderm that form during gastrulation, corresponding to primitive ectoderm during gastrulation and to the definitive ectoderm after gastrulation[ZFA] + + ZFIN:curator + + + + + In pregastrula zebrafish embryos, the epiblast is an inverted cup of cells that sits on top of a large yolk cell. (...) In amniote embryos (mammals and birds), gastrulation initiates in an epithelial layer called the epiblast. Cells in the epiblast undergo an epithelial to mesenchymal transition (EMT), migrate through the primitive streak (PS), and incorporate in the middle (mesoderm) or outer (endoderm) layer. The presumptive definitive endoderm (DE) cells invade and displace an outer layer of extraembryonic tissue cells, the hypoblast in chick and the visceral endoderm (VE) in mouse, which form supporting structures such as the yolk sac.[uncertain][VHOG] + 2012-09-17 + VHOG:0000243 + VHOG + + DOI:10.1146/annurev.cellbio.042308.113344 Zorn AM, Wells JM, Vertebrate endoderm development and organ formation. Annual Review of Cell Developmental Biology (2009) + + + + + epiblast + VHOG:0000243 + + + + + ectoblast + MP:0003886 + + + + + epiblastus + + + + + + + primitive ectoderm + VHOG:0000243 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + One of a series of paired bulges that develop along the lateral walls of the foregut. The pharyngeal arches have developmental contributions from endoderm, mesoderm, and neural crest cells and are separated by anterior lateral endoderm out-pockets known as pharyngeal pouches. + One of a series of bony or cartilaginous arches that develop in the walls of the mouth cavity and pharynx of the embryo.[AAO] + A conserved feature of all vertebrate embryos is the presence of a series of bulges on the lateral surface of the head, the pharyngeal arches; it is within these structures that the nerves, muscles and skeletal components of the pharyngeal apparatus are laid down.[well established][VHOG] + Numbered cranial to caudal. different in mammals. branchial arch = ZFA:0001613 pharyngeal arch 3-7. generally gill arch 1 = pharyngeal arch 3. terminology varies as to whether branchial arch follows gill or pharyngeal numbering + + + + AAO:0010359 + BTO:0001785 + EFO:0000959 + EHDAA:571 + EMAPA:16117 + FMA:293015 + GAID:1292 + MAT:0000242 + MESH:A16.254.160 + MIAA:0000242 + NCIT:C34249 + TAO:0001306 + UMLS:C0080322 + VHOG:0000155 + XAO:0000096 + ZFA:0001306 + pharyngeal arches + branchial arch + uberon + arcus pharyngei + visceral arch + UBERON:0002539 + + + + + pharyngeal arch + http://upload.wikimedia.org/wikipedia/commons/8/8b/Gray41.png + + + + + + EHDAA2 + + + + + + + + + + + + + + + + + + + + + + + + + + + One of a series of paired bulges that develop along the lateral walls of the foregut. The pharyngeal arches have developmental contributions from endoderm, mesoderm, and neural crest cells and are separated by anterior lateral endoderm out-pockets known as pharyngeal pouches. + + + ZFA:yb + + + + + One of a series of bony or cartilaginous arches that develop in the walls of the mouth cavity and pharynx of the embryo.[AAO] + 2012-06-20 + AAO:0010359 + AAO + NLM:branchial+arch + + + + + A conserved feature of all vertebrate embryos is the presence of a series of bulges on the lateral surface of the head, the pharyngeal arches; it is within these structures that the nerves, muscles and skeletal components of the pharyngeal apparatus are laid down.[well established][VHOG] + 2012-09-17 + VHOG:0000155 + VHOG + + DOI:10.1111/j.1469-7580.2005.00472.x Graham A, Okabe M and Quinlan R, The role of the endoderm in the development and evolution of the pharyngeal arches. J Anat (2005) + + + + + UMLS:C0080322 + ncithesaurus:Pharyngeal_Arch + + + + + pharyngeal arches + + + + + + branchial arch + BTO:0001785 + MP:0002884 + + + + + arcus pharyngei + + + + + + + + + + + + + + + + + Ectodermal placode that develops in the head into a part of the sensory nervous system. With a few exceptions (lens, adenohypophyseal), cranial placodes are neurogenic. + Do not merge with neurogenic placode + Comparisons of developmental gene expression suggest that the anterior ectoderm in amphioxus may be homologous to the vertebrate olfactory placode, the only vertebrate placode with primary, not secondary, neurons + The term placode or placodes also applies to developing organs such as teeth, mammary glands, hair follicles, feathers and scales. We include a separate parent class for this. to avoid confusion, we include neurogenic placode as a subclass + ectodermal placode + placode + AAO:0010466 + EFO:0001650 + FMA:293966 + MAT:0000369 + MIAA:0000369 + XAO:0000305 + ectodermal cranial placode + uberon + cranial placodes + UBERON:0002546 + + cranial placode + + + + + + cjm + + + + + Ectodermal placode that develops in the head into a part of the sensory nervous system. With a few exceptions (lens, adenohypophyseal), cranial placodes are neurogenic. + + + + + + + + + + Comparisons of developmental gene expression suggest that the anterior ectoderm in amphioxus may be homologous to the vertebrate olfactory placode, the only vertebrate placode with primary, not secondary, neurons + + + + + + ectodermal placode + + FMA:293966 + + + + + + placode + + + + + + ectodermal cranial placode + UBERON:cjm + + + + + cranial placodes + XAO:0000305 + + + + + + + + + + + + + + + + Anatomical space which contains portions of one or more body substances and is bounded by the internal surface of one maximally connected anatomical structure. Examples: cranial cavity, pharyngeal recess space, nasal cavity, tooth socket, cavity of serous sac, lumen of stomach, lumen of artery, fornix of vagina. + cavity + BIRNLEX:1011 + EMAPA:37442 + FMA:67552 + MA:0002447 + NCIT:C34007 + galen:Cavity + uberon + UBERON:0002553 + + anatomical cavity + + + + + Anatomical space which contains portions of one or more body substances and is bounded by the internal surface of one maximally connected anatomical structure. Examples: cranial cavity, pharyngeal recess space, nasal cavity, tooth socket, cavity of serous sac, lumen of stomach, lumen of artery, fornix of vagina. + FMA:67552 + + + + + EMAPA:37442 + MA:th + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Anatomical divisons of the brain according to one or more criteria, e.g. cytoarchitectural, gross anatomy. Parts may be contiguous in 3D or not, e.g., basal ganglia. + + + BIRNLEX:1167 + FMA:55676 + NCIT:C13031 + UMLS:C0445620 + anatomical structure of brain + biological structure of brain + brain anatomical structure + brain biological structure + brain part + neuraxis segment + neuroanatomical region + segment of brain + uberon + UBERON:0002616 + + regional part of brain + + + + + Anatomical divisons of the brain according to one or more criteria, e.g. cytoarchitectural, gross anatomy. Parts may be contiguous in 3D or not, e.g., basal ganglia. + BIRNLEX:1167 + + + + + UMLS:C0445620 + ncithesaurus:Brain_Part + + + + + anatomical structure of brain + OBOL:automatic + + + + + biological structure of brain + OBOL:automatic + + + + + brain anatomical structure + OBOL:automatic + + + + + brain biological structure + OBOL:automatic + + + + + neuraxis segment + FMA:55676 + + + + + segment of brain + BIRNLEX:1167 + + + + + + + + + + + + + + + A wall, dividing a cavity or structure into smaller ones[WP]. + septal + + AAO:0011127 + FMA:86461 + OpenCyc:Mx4rrqot_on_EdaAAAACs0uFOQ + septa + uberon + UBERON:0003037 + + general anatomical term in FMA + septum + + + + + A wall, dividing a cavity or structure into smaller ones[WP]. + + + + + + septa + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The part of the brain that is the morphological boundary between the midbrain and hindbrain and that is the location of an organizing center which patterns the midbrain and hindbrain primordia of the neural plate. + consider adding class for organizer. Consider adding separate class for isthmus as a structure + Lampreys also have an MHB [midbrain hindbrain boundary], expressing a similar repertoire of regulatory gene cognates as in gnathostomes.[well established][VHOG] + + AAO:0011064 + DMBA:16810 + EHDAA2:0004395 + EHDAA:5789 + EMAPA:32857 + NCIT:C93172 + TAO:0000042 + VHOG:0000649 + XAO:0000016 + ZFA:0000042 + MHB + mid-hindbrain boundary + mid-hindbrain junction + midbrain hindbrain boundary + uberon + isthmic organizer territory + isthmo-cerebellar region + isthmus + isthmus/MHB + UBERON:0003052 + + + + midbrain-hindbrain boundary + + + + + + ZFA + + + + + + + + + + + + ZFA + + + + + + + + + + + ZFA + + + + + The part of the brain that is the morphological boundary between the midbrain and hindbrain and that is the location of an organizing center which patterns the midbrain and hindbrain primordia of the neural plate. + GO:0021555 + + + + + Lampreys also have an MHB [midbrain hindbrain boundary], expressing a similar repertoire of regulatory gene cognates as in gnathostomes.[well established][VHOG] + 2012-09-17 + VHOG:0000649 + VHOG + + DOI:10.1016/j.ydbio.2005.02.008 Murakami Y, Uchida K, Rijli FM and Kuratani S, Evolution of the brain developmental plan: Insights from agnathans. Developmental Biology (2005) + + + + + isthmic organizer territory + XAO:0000016 + + + + + isthmo-cerebellar region + VHOG:0000649 + + + + + isthmus/MHB + Geisha:syn + NCBITaxon:8782 + + + + + + + + + + + + + + + + + + + + + + A temporary epithelium that derives from the outer layer of the ectdoerm and is shed once the inner layer differentiates to form a true epidermis. + The outermost epidermal layer covering the fish at embryonic stages; derived from the EVL and thought to eventually be replaced by the superficial stratum of the epidermis. Sometimes used synonymously with EVL. Le Guellec et al, 2004.[TAO] + relationship type change: OBO_REL:part_of ectoderm (TAO:0000016) CHANGED TO: develops_from ectoderm (UBERON:0000924)[TAO] + In mice, the first non-basal layer formed at ~E9.5; it is a temporary structure composed of simple squamous epithelium that serves as the first barrier to the embryo's physical environment, exists throughout the entire keratinocyte stratification process, and sheds off at ~E17, when it is replaced by corneocytes[MP] + In some mammals, Eyelid Fusion is thought to be driven by a population of cells which are derived from the periderm, the outermost layer of the developing epidermis + Originally the epidermis is one layer thick, in most vertebrates it soon becomes a two-layered structure. The outer layer gives rise to the periderm. The periderm goes through distinct developmental phases and is ultimately sloughed into the amniotic fluid when differentiation of the underlying epidermal layers is complete. The function of the periderm is not known, but is thought to be related to transport/exchange between the fetus and the amniotic fluid (http://courses.washington.edu/hubio567/devbio/periderm.html) + + EHDAA2:0001846 + EHDAA:6538 + FMA:295662 + NCIT:C34247 + TAO:0001185 + UMLS:C1518973 + VHOG:0001680 + XAO:0000029 + ZFA:0001185 + skin periderm + uberon + EVL + epidermis epithelial layer + epidermis outer layer + epitrichium + periderm + UBERON:0003055 + + + periderm + + + + + + EHDAA2 + + + + + + + + + + + EHDAA2 + + + + + + + + + + + ZFA + + + + + A temporary epithelium that derives from the outer layer of the ectdoerm and is shed once the inner layer differentiates to form a true epidermis. + ISBN:9780878932504 + + + + + The outermost epidermal layer covering the fish at embryonic stages; derived from the EVL and thought to eventually be replaced by the superficial stratum of the epidermis. Sometimes used synonymously with EVL. Le Guellec et al, 2004.[TAO] + 2012-08-14 + TAO:0001185 + TAO + ZFIN:curator + + + + + relationship type change: OBO_REL:part_of ectoderm (TAO:0000016) CHANGED TO: develops_from ectoderm (UBERON:0000924)[TAO] + 2012-08-14 + TAO:0001185 + TAO + + + + + UMLS:C1518973 + ncithesaurus:Periderm + + + + + skin periderm + EHDAA2:0001846 + + + + + EVL + ZFA:0001185 + + + + + epitrichium + MP:0013530 + + + + + + + + + + + + + + + + + + + + + + The portion of neural plate anterior to the mid-hindbrain junction. + (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG] + AAO:0011084 + TAO:0007016 + VHOG:0001200 + XAO:0000045 + ZFA:0007016 + uberon + anterior neural plate + UBERON:0003056 + pre-chordal neural plate + + + + + The portion of neural plate anterior to the mid-hindbrain junction. + XB:curator + + + + + (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG] + 2012-09-17 + VHOG:0001200 + VHOG + + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28 + + + + + + + + + + + + + + + + + + + + + + The portion of neural plate posterior to the mid-hindbrain junction. + (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG] + TAO:0007017 + VHOG:0001201 + XAO:0000046 + ZFA:0007017 + uberon + posterior neural plate + UBERON:0003057 + chordal neural plate + + + + + The portion of neural plate posterior to the mid-hindbrain junction. + XB:curator + + + + + (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG] + 2012-09-17 + VHOG:0001201 + VHOG + + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form. + Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form. Kimmel et al, 1995.[TAO] + It is reasonable to assume that the proximate invertebrate ancestor of the vertebrates had an amphioxus-like tail bud in its larval stage. This archetypal tail bud would have (...) (3) lacked any component of mesenchyme cells, (4) budded off new mesodermal segments directly, without any intervening zone of presomitic mesoderm (...). Then, early in vertebrate evolution, epithelium-to-mesenchyme interconversions (and the gene networks for effecting them) became prominent features of development. (...) In any case, conspicuous mesenchymal components tended to be added to the vertebrate tail bud itself. In addition, a mesenchymatous presomitic mesoderm (not a part of the tail bud proper) came to intervene between the tail bud and the forming somites.[well established][VHOG] + AAO:0011086 + EFO:0001982 + EMAPA:16189 + EMAPA:16752 + TAO:0000279 + VHOG:0000559 + XAO:0000057 + ZFA:0000279 + segmental plate + unsegmented paraxial mesoderm + uberon + PSM + presumptive somite mesoderm + somitogenic mesoderm + somitomeric mesoderm + unsegmented mesenchyme + UBERON:0003059 + + + presomitic mesoderm + + + + + + + + + + + Bgee:AN + + + + + Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form. + ZFIN:curator + + + + + Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form. Kimmel et al, 1995.[TAO] + 2012-08-14 + TAO:0000279 + TAO + ZFIN:curator + + + + + It is reasonable to assume that the proximate invertebrate ancestor of the vertebrates had an amphioxus-like tail bud in its larval stage. This archetypal tail bud would have (...) (3) lacked any component of mesenchyme cells, (4) budded off new mesodermal segments directly, without any intervening zone of presomitic mesoderm (...). Then, early in vertebrate evolution, epithelium-to-mesenchyme interconversions (and the gene networks for effecting them) became prominent features of development. (...) In any case, conspicuous mesenchymal components tended to be added to the vertebrate tail bud itself. In addition, a mesenchymatous presomitic mesoderm (not a part of the tail bud proper) came to intervene between the tail bud and the forming somites.[well established][VHOG] + 2012-09-17 + VHOG:0000559 + VHOG + + DOI:10.1006/dbio.2001.0460 Schubert M, Holland LZ, Dale Stokes M and Holland ND, Three Amphoxius Wnt Genes (AmphiWnt3, AmphiWnt5, and AmphiWnt6) Associated with the Tail Bud: the Evolution of Somitogenesis in Chordates. Developmental Biology (2001) + + + + + unsegmented paraxial mesoderm + + + + + + somitomeric mesoderm + GO:0002075 + + + + + unsegmented mesenchyme + VHOG:0000559 + + + + + + + + + + + + + + + + + + + + + Blood islands are structures in the developing embryo which lead to many different parts of the circulatory system. They primarily derive from plexuses formed from angioblasts. Within them, vacuoles appear through liquefaction of the central part of the syncytium into plasma. The lumen of the blood vessels thus formed is probably intracellular. The flattened cells at the periphery form the endothelium. The nucleated red blood corpuscles develop either from small masses of the original angioblast left attached to the inner wall of the lumen or directly from the flat endothelial cells. In either case the syncytial mass thus formed projects from and is attached to the wall of the vessel. Such a mass is known as a blood island and hemoglobin gradually accumulates within it. Later the cells on the surface round up, giving the mass a mulberry-like appearance. Then the red blood cells break loose and are carried away in the plasma. Such free blood cells continue to divide. Blood islands have been seen in the area vasculosa in the omphalomesenteric vein and arteries, and in the dorsal aorta[WP, unvetted]. + Nests of developing blood cells arising late in the segmentation period from the intermediate mass, and located in the anterior-ventral tail, just posterior to the yolk extension. Kimmel et al, 1995.[TAO] + Region located on the ventral surface of the developing embryo that is a site of hematopoiesis and that is analogous to the yolk sac blood islands of higher vertebrates.[AAO] + relationship loss: part_of intermediate cell mass of mesoderm (TAO:0000033)[TAO] + Small clusters of mesodermal cells called blood islands mark the embryonic debut of the cardiovascular system (in vertebrates) (reference 1); In birds and mammals, primitive hemangioblasts are extraembryonic, populating the yolk sac as the so-called blood islands (reference 2).[well established][VHOG] + EHDAA2 distinguishes 3 types, but does not have a superclass. The VHOG class may refer to yolk sac + ventral lateral plate mesoderm + + + AAO:0011006 + EFO:0003489 + EHDAA:207 + NCIT:C34113 + TAO:0000094 + TE:E5.11.2.0.0.0.4 + UMLS:C1511224 + VHOG:0000085 + XAO:0000067 + ZFA:0000094 + blood islands + uberon + VBI + caudal hematopoietic tissue + posterior ICM + posterior blood island + ventral blood island + UBERON:0003061 + + + + + blood island + + + + + Blood islands are structures in the developing embryo which lead to many different parts of the circulatory system. They primarily derive from plexuses formed from angioblasts. Within them, vacuoles appear through liquefaction of the central part of the syncytium into plasma. The lumen of the blood vessels thus formed is probably intracellular. The flattened cells at the periphery form the endothelium. The nucleated red blood corpuscles develop either from small masses of the original angioblast left attached to the inner wall of the lumen or directly from the flat endothelial cells. In either case the syncytial mass thus formed projects from and is attached to the wall of the vessel. Such a mass is known as a blood island and hemoglobin gradually accumulates within it. Later the cells on the surface round up, giving the mass a mulberry-like appearance. Then the red blood cells break loose and are carried away in the plasma. Such free blood cells continue to divide. Blood islands have been seen in the area vasculosa in the omphalomesenteric vein and arteries, and in the dorsal aorta[WP, unvetted]. + + + + + + Nests of developing blood cells arising late in the segmentation period from the intermediate mass, and located in the anterior-ventral tail, just posterior to the yolk extension. Kimmel et al, 1995.[TAO] + 2012-08-14 + TAO:0000094 + TAO + ZFIN:curator + + + + + Region located on the ventral surface of the developing embryo that is a site of hematopoiesis and that is analogous to the yolk sac blood islands of higher vertebrates.[AAO] + 2012-06-20 + AAO:0011006 + AAO + AAO:EJS + + + + + relationship loss: part_of intermediate cell mass of mesoderm (TAO:0000033)[TAO] + 2012-08-14 + TAO:0000094 + TAO + + + + + Small clusters of mesodermal cells called blood islands mark the embryonic debut of the cardiovascular system (in vertebrates) (reference 1); In birds and mammals, primitive hemangioblasts are extraembryonic, populating the yolk sac as the so-called blood islands (reference 2).[well established][VHOG] + 2012-09-17 + VHOG:0000085 + VHOG + + ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.450, DOI:10.1146/annurev.cellbio.22.010605.093317 Hartenstein V, Blood cells and blood cell development in the animal kingdom. Annual Review of Cell and Developmental Biology (2006) + + + + + EHDAA2 distinguishes 3 types, but does not have a superclass. The VHOG class may refer to yolk sac + EHDAA2 + + + + + UMLS:C1511224 + ncithesaurus:Blood_Island + + + + + blood islands + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A horseshoe-shaped thickening of the endoderm at the cranial (rostral) end of the primitive streak formed by the involution of Spemann's organizer cells which, together with the notochord, induces the formation of the neural plate from the overlying ectodermal cells and contributes mesodermal type cells to the surrounding tissue + TODO - check; developmental relationship to anterior hypoblast in ZFA? + Axial hypoblast located anterior to the chorda mesoderm; the polster is its most anterior region. Kimmel et al, 1995.[TAO] + Axial mesoderm that lies anterior to the notochord and that underlies the forebrain. [Amphioxus_goosecoid_and_the_evolution_of_the_head_organizer_and_prechordal_plate._Evolution_and_Development_(2008)_2(6):303-310, Neidert_AH, Panopoulou_G_and_Langeland_JA][VHOG] + There are two opposing models that can potentially explain the differences in gsc (goosecoid) expression between amphioxus and vertebrates. In one model, the vertebrate gsc expression pattern more closely resembles the common ancestral state and the amphioxus gsc expression pattern is a derivation associated with its unique morphology. (...) In an alternate model, the amphioxus gsc expression pattern most closely represents the common ancestral state and the vertebrate pattern is derived. This model suggests that the evolution of vertebrates was accompanied by the segregation of gsc expression, from a more general domain underlying the entire brain anlage to a distinct forebrain organizer domain and subsequent prechordal plate. We feel this second model is more parsimonious than the first model in that what would be novel anterior gsc expression in vertebrates directly correlates with a novel vertebrate anterior structure, the prechordal plate.[well established][VHOG] + UBERON:0004881 + head mesenchyme + head mesoderm + + AAO:0011085 + EHDAA2:0001493 + EHDAA:181 + FMA:295532 + TAO:0000060 + VHOG:0000086 + XAO:0000079 + ZFA:0000060 + uberon + UBERON:0003063 + + + + prechordal plate + + + + + + + + + + + ZFA + + + + + + + + + + + PMID:16313393 + + + + + A horseshoe-shaped thickening of the endoderm at the cranial (rostral) end of the primitive streak formed by the involution of Spemann's organizer cells which, together with the notochord, induces the formation of the neural plate from the overlying ectodermal cells and contributes mesodermal type cells to the surrounding tissue + ISBN:0838580343 + MP:0004387 + + + + + Axial hypoblast located anterior to the chorda mesoderm; the polster is its most anterior region. Kimmel et al, 1995.[TAO] + 2012-08-14 + TAO:0000060 + TAO + ZFIN:curator + + + + + Axial mesoderm that lies anterior to the notochord and that underlies the forebrain. [Amphioxus_goosecoid_and_the_evolution_of_the_head_organizer_and_prechordal_plate._Evolution_and_Development_(2008)_2(6):303-310, Neidert_AH, Panopoulou_G_and_Langeland_JA][VHOG] + 2012-09-17 + VHOG:0000086 + VHOG + + + + + + There are two opposing models that can potentially explain the differences in gsc (goosecoid) expression between amphioxus and vertebrates. In one model, the vertebrate gsc expression pattern more closely resembles the common ancestral state and the amphioxus gsc expression pattern is a derivation associated with its unique morphology. (...) In an alternate model, the amphioxus gsc expression pattern most closely represents the common ancestral state and the vertebrate pattern is derived. This model suggests that the evolution of vertebrates was accompanied by the segregation of gsc expression, from a more general domain underlying the entire brain anlage to a distinct forebrain organizer domain and subsequent prechordal plate. We feel this second model is more parsimonious than the first model in that what would be novel anterior gsc expression in vertebrates directly correlates with a novel vertebrate anterior structure, the prechordal plate.[well established][VHOG] + 2012-09-17 + VHOG:0000086 + VHOG + + DOI:10.1046/j.1525-142x.2000.00073.x Neidert AH, Panopoulou G and Langeland JA, Amphioxus goosecoid and the evolution of the head organizer and prechordal plate. Evolution and Development (2008) + + + + + head mesenchyme + XAO:0000079 + + + + + head mesoderm + XAO:0000079 + + + + + + + + + + + + + + + + + + + + + + The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord. + The portion of the mesoderm underlying the midline of the embryo. [Gastrulation:_From_cells_to_embryo_(2004)_Cold_Spring_Harbor, Glossary_XV, New_York:_Cold_Spring_Harbor_Laboratory_Press, Stern_CD][VHOG] + + AAO:0011017 + EFO:0003647 + TAO:0001204 + VHOG:0000107 + XAO:0000205 + ZFA:0001204 + uberon + chordamesoderm + UBERON:0003068 + + + axial mesoderm + http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png + + + + + The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord. + + GO:0048318 + + + + + The portion of the mesoderm underlying the midline of the embryo. [Gastrulation:_From_cells_to_embryo_(2004)_Cold_Spring_Harbor, Glossary_XV, New_York:_Cold_Spring_Harbor_Laboratory_Press, Stern_CD][VHOG] + 2012-09-17 + VHOG:0000107 + VHOG + + + + + + chordamesoderm + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Portion of tissue that is part of the anterior neural keel and will form the optic vesicle[ZFA]. A paired ectodermal placode that becomes invaginated to form the embryonic lens vesicles. + TODO - check that GO's optic placode is the same as ZFA's eye primordium; we may want to have separate term for ocular primordium precursor. XAO has both optic field and eye primordium. + UBERON:0005060 + AAO:0011038 + EFO:0003541 + EHDAA2:0004431 + TAO:0000570 + XAO:0000227 + XAO:0004090 + ZFA:0000570 + eye placode + occular primordium + ocular primordium + optic placode + optic placode of camera-type eye + optic primordium + uberon + eye anlage + eye field + optic field + optic placodes + UBERON:0003071 + + eye primordium + + + + + + EHDAA2 + + + + + + + + + + + + XAO + + + + + Portion of tissue that is part of the anterior neural keel and will form the optic vesicle[ZFA]. A paired ectodermal placode that becomes invaginated to form the embryonic lens vesicles. + GO:0046619 + ZFA:0000570 + + + + + TODO - check that GO's optic placode is the same as ZFA's eye primordium; we may want to have separate term for ocular primordium precursor. XAO has both optic field and eye primordium. + GO + + + + + eye placode + OBOL:automatic + + + + + optic placode + GO:0046619 + + + + + optic placode of camera-type eye + + GO:0046619 + + + + + eye anlage + XAO:0000227 + + + + + optic placodes + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Multi-tissue structure that is comprised of neural and non-neural epithelial layers which will form the retina and retinal pigmented epithelium of the mature eye[ZFA]. double walled structured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye[MP]. + (...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup.[well established][VHOG] + + + BTO:0005351 + EHDAA2:0001303 + EHDAA:2912 + EMAPA:16674 + NCIT:C34233 + TAO:0001202 + UMLS:C0231109 + VHOG:0000167 + ZFA:0001202 + uberon + eye cup + eyecup + ocular cup + ophtalmic cup + UBERON:0003072 + + + optic cup + + + + + + + + + + + ZFA + + + + + + + + + + + ZFA + + + + + Multi-tissue structure that is comprised of neural and non-neural epithelial layers which will form the retina and retinal pigmented epithelium of the mature eye[ZFA]. double walled structured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye[MP]. + + MP:0004269 + ZFA:0001202 + + + + + (...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup.[well established][VHOG] + 2012-09-17 + VHOG:0000167 + VHOG + + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429 + + + + + UMLS:C0231109 + ncithesaurus:Optic_Cup + + + + + eyecup + BTO:0005351 + + + + + ocular cup + VHOG:0000167 + + + + + ophtalmic cup + BTO:0005351 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A thickened portion of ectoderm which serves as the precursor to the lens. SOX2 and Pou2f1 are involved in its development[WP]. + Ectodermal primordium of the lens of the eye. Kimmel et al, 1995.[TAO] + (...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The optic cup induces the overlying surface ectoderm first to thicken as a lens placode and then to invaginate and form a lens vesicle that differentiates into the lens.[well established][VHOG] + Classical transplantation experiments using amphibian embryos suggested that the optic vesicle is the source of lens-inducing signals sufficient to generate lens tissues in competent ectoderm (reviewed in Grainger et al., 1996). More recent findings suggest a multistep model for lens induction. There is now good evidence that lens specification occurs at the neurula stage, before the optic vesicle contact the surface ectoderm, and that neural crest cell migration in the frontonasal region is required to restrict the position of the lens placode (Bailey et al., 2006) + + + AAO:0011055 + EFO:0003494 + EHDAA2:0000982 + EHDAA:2908 + EMAPA:16672 + FMA:296767 + NCIT:C34202 + TAO:0000122 + UMLS:C1517770 + VHOG:0000166 + XAO:0000240 + ZFA:0000122 + uberon + lens placodes + placoda lentis + UBERON:0003073 + + + + + lens placode + http://upload.wikimedia.org/wikipedia/commons/2/2f/Gray864.png + + + + + + NCBIBook:NBK53175 + + + + + A thickened portion of ectoderm which serves as the precursor to the lens. SOX2 and Pou2f1 are involved in its development[WP]. + + ZFIN:curator + + + + + Ectodermal primordium of the lens of the eye. Kimmel et al, 1995.[TAO] + 2012-08-14 + TAO:0000122 + TAO + ZFIN:curator + + + + + (...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The optic cup induces the overlying surface ectoderm first to thicken as a lens placode and then to invaginate and form a lens vesicle that differentiates into the lens.[well established][VHOG] + 2012-09-17 + VHOG:0000166 + VHOG + + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429 + + + + + Classical transplantation experiments using amphibian embryos suggested that the optic vesicle is the source of lens-inducing signals sufficient to generate lens tissues in competent ectoderm (reviewed in Grainger et al., 1996). More recent findings suggest a multistep model for lens induction. There is now good evidence that lens specification occurs at the neurula stage, before the optic vesicle contact the surface ectoderm, and that neural crest cell migration in the frontonasal region is required to restrict the position of the lens placode (Bailey et al., 2006) + NCBIBook:NBK53175 + + + + + UMLS:C1517770 + ncithesaurus:Lens_Placodes + + + + + lens placodes + ZFA:0000122 + + + + + + placoda lentis + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA] + The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium. Kimmel et al, 1995.[TAO] + (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG] + + + + AAO:0011072 + BTO:0001765 + DHBA:10153 + DMBA:15565 + EHDAA:346 + EHDAA:902 + EMAPA:35593 + FMA:293879 + NCIT:C34225 + RETIRED_EHDAA2:0001252 + TAO:0000132 + UMLS:C0920623 + VHOG:0000068 + XAO:0000249 + ZFA:0000132 + uberon + lamina neuralis + presumptive central nervous system + UBERON:0003075 + + + + neural plate + Neural:Crest.png + + + + + + + + + + + Wikipedia + + + + + + + + + + + Bgee:AN + + + + + A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA] + + ISBN:0815318960 + OMD:neural+plate + ZFIN:curator + + + + + The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium. Kimmel et al, 1995.[TAO] + 2012-08-14 + TAO:0000132 + TAO + ZFIN:curator + + + + + (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG] + 2012-09-17 + VHOG:0000068 + VHOG + + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28 + + + + + UMLS:C0920623 + ncithesaurus:Neural_Plate + + + + + lamina neuralis + + + + + + + + + + + + + + + + + + + + + + + + + (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG] + AAO:0011082 + TAO:0007037 + VHOG:0001383 + XAO:0000250 + ZFA:0007037 + uberon + UBERON:0003076 + posterior neural tube + + + + + + lexical + + + + + (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG] + 2012-09-17 + VHOG:0001383 + VHOG + + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube[GO] + Mesoderm lateral to the neural tube and notochord that is divided into cranial and post-cranial portions. The trunk portions further segment into somites.[AAO] + Presently, Cephalochordata, Urochordata, and Vertebrata are placed as subphyla of the phylum Chordata, in which the overall organization of embryonic tissues (dorsal hollow nerve cord, ventral digestive tract, axial notochord, and bilateral paraxial mesoderm) is largely conserved. In contrast, the echinoderms and hemichordates are sister groups of the chordates and they lack the notochord and paraxial mesoderm. Thus, the basic mesodermal organization of vertebrates must have appeared first in the common ancestor of the chordates.[well established][VHOG] + note that all AOs differ in the relationship between this structure and the mesoderm; in ZFA it is a subclass (and this is implied by the GO definition and GO relationships), in AAO it is part of, and in EHDAA2 it develops from the mesoderm (but in EHDAA2 the naming convention is to use 'paraxial mesenchyme', rather than 'paraxial mesoderm'). Also in ZFA it is part of the trunk whereas this conflicts with the division into head and trunk in ehdaa2 (which we follow here) + + + + AAO:0010568 + EFO:0003515 + EMAPA:16183 + EMAPA:16751 + FMA:293145 + NCIT:C34244 + TAO:0000255 + UMLS:C1284009 + VHOG:0000114 + XAO:0000259 + ZFA:0000255 + paraxial mesenchyme + somitic mesoderm + uberon + mesoderma paraxiale + UBERON:0003077 + + + + paraxial mesoderm + http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png + + + + + + EHDAA2 + + + + + + + + + + + Bgee:AN + + + + + The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube[GO] + + GO:0048339 + + + + + Mesoderm lateral to the neural tube and notochord that is divided into cranial and post-cranial portions. The trunk portions further segment into somites.[AAO] + 2012-06-20 + AAO:0010568 + AAO + AAO:EJS + + + + + Presently, Cephalochordata, Urochordata, and Vertebrata are placed as subphyla of the phylum Chordata, in which the overall organization of embryonic tissues (dorsal hollow nerve cord, ventral digestive tract, axial notochord, and bilateral paraxial mesoderm) is largely conserved. In contrast, the echinoderms and hemichordates are sister groups of the chordates and they lack the notochord and paraxial mesoderm. Thus, the basic mesodermal organization of vertebrates must have appeared first in the common ancestor of the chordates.[well established][VHOG] + 2012-09-17 + VHOG:0000114 + VHOG + + DOI:10.1002/dvdy.21177 Kusakabe R and Kuratani S. Evolutionary perspectives from development of mesodermal components in the lamprey. Developmental dynamics (2007) + + + + + note that all AOs differ in the relationship between this structure and the mesoderm; in ZFA it is a subclass (and this is implied by the GO definition and GO relationships), in AAO it is part of, and in EHDAA2 it develops from the mesoderm (but in EHDAA2 the naming convention is to use 'paraxial mesenchyme', rather than 'paraxial mesoderm'). Also in ZFA it is part of the trunk whereas this conflicts with the division into head and trunk in ehdaa2 (which we follow here) + ZFA + + + + + UMLS:C1284009 + ncithesaurus:Paraxial_Mesoderm + + + + + paraxial mesenchyme + + + ZFA:0000255 + + + + + somitic mesoderm + ISBN:9780878932504 + + + + + mesoderma paraxiale + + + + + + + + + + + + + + + + + + + + + + + + TODO - add grouping class for the anterior end of the neural tube at all stages + (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG] + AAO:0011012 + TAO:0007038 + VHOG:0001384 + XAO:0000307 + ZFA:0007038 + uberon + UBERON:0003080 + anterior neural tube + + + + + + lexical + + + + + (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG] + 2012-09-17 + VHOG:0001384 + VHOG + + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28 + + + + + + + + + + + + + + + + + + + + + + + + Portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures[MP]. + Portion of mesoderm traditionally thought to give rise to limb bones and parts of the girdles.[AAO] + The portion of the mesoderm of the trunk of vertebrate embryos lying lateral to the intermediate mesoderm. [...] [It] subdivides into two plates: one dorsal, called the somatopleure, and one ventral, called the splanchnopleure. [Gastrulation:_From_cells_to_embryo_(2004)_Cold_Spring_Harbor, Glossary_XV, New_York:_Cold_Spring_Harbor_Laboratory_Press, Stern_CD][VHOG] + A ventrolateral zone of amphioxus mesoderm grows down to surround the gut. Homology of this zone to the lateral plate mesoderm of vertebrates is supported by site of origin and fate.[well established][VHOG] + subclass of mesoderm in ZFA. + UBERON:0006258 + + + + AAO:0010574 + EHDAA2:0000919 + EHDAA:379 + EMAPA:16179 + FMA:293149 + NCIT:C34199 + TAO:0000121 + UMLS:C1517749 + VHOG:0000118 + XAO:0000311 + ZFA:0000121 + LPM + lateral mesoderm + uberon + lateral plate + lateral plate mesenchyme + mesoderma laminae lateralis + UBERON:0003081 + + + lateral plate mesoderm + http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png + + + + + + EHDAA2 + + + + + + + + + + + EHDAA2 + VHOG + + + + + Portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures[MP]. + + MP:0010117 + + + + + Portion of mesoderm traditionally thought to give rise to limb bones and parts of the girdles.[AAO] + 2012-06-20 + AAO:0010574 + AAO + AAO:EJS + + + + + The portion of the mesoderm of the trunk of vertebrate embryos lying lateral to the intermediate mesoderm. [...] [It] subdivides into two plates: one dorsal, called the somatopleure, and one ventral, called the splanchnopleure. [Gastrulation:_From_cells_to_embryo_(2004)_Cold_Spring_Harbor, Glossary_XV, New_York:_Cold_Spring_Harbor_Laboratory_Press, Stern_CD][VHOG] + 2012-09-17 + VHOG:0000118 + VHOG + + + + + + A ventrolateral zone of amphioxus mesoderm grows down to surround the gut. Homology of this zone to the lateral plate mesoderm of vertebrates is supported by site of origin and fate.[well established][VHOG] + 2012-09-17 + VHOG:0000118 + VHOG + + DOI:10.1073/pnas.97.9.4449 Shimeld SM and Holland PW. Vertebrate innovations. PNAS (2000) + + + + + subclass of mesoderm in ZFA. + ZFA + + + + + UMLS:C1517749 + ncithesaurus:Lateral_Mesoderm + + + + + LPM + ZFA:0000121 + + + + + + lateral mesoderm + GO:0048368 + + + + + lateral plate mesenchyme + EHDAA2:0000919 + + + + + mesoderma laminae lateralis + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline to form the heart rudiment or cone. + should probably be merged with heart rudiment. + Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline between 21 and 26 somites to form the heart rudiment or cone. Stainier 2001.[TAO] + The fused aspects of ventral mesoderm, which have migrated from either side of the prechordal plate, and fused ventrally, just behind the cement gland. They will give rise to the endocardium at NF stage 27&28.[AAO] + relationship loss: develops_from lateral mesoderm (TAO:0001065)[TAO] + + AAO:0011044 + BTO:0001887 + NCIT:C34276 + TAO:0000028 + UMLS:C1514450 + XAO:0000336 + ZFA:0000028 + uberon + cardiac field + fused heart primordium + UBERON:0003084 + + heart primordium + + + + + + Obol + + + + + + + + + + + ZFA + + + + + + + + + + + ZFA + + + + + + + + + + + XAO + + + + + Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline to form the heart rudiment or cone. + ZFIN:curator + + + + + Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline between 21 and 26 somites to form the heart rudiment or cone. Stainier 2001.[TAO] + 2012-08-14 + TAO:0000028 + TAO + ZFIN:curator + + + + + The fused aspects of ventral mesoderm, which have migrated from either side of the prechordal plate, and fused ventrally, just behind the cement gland. They will give rise to the endocardium at NF stage 27&28.[AAO] + 2012-06-20 + AAO:0011044 + AAO + XAO:curator + + + + + relationship loss: develops_from lateral mesoderm (TAO:0001065)[TAO] + 2012-08-14 + TAO:0000028 + TAO + + + + + UMLS:C1514450 + ncithesaurus:Primordium_of_the_Heart + + + + + cardiac field + ZFA:0000028 + + + + + + + + + + + + + + + + + Ventral somitic compartment that is a precursor of the axial skeleton[XAO]. Sclerotomes eventually differentiate into the vertebrae and most of the skull. The caudal (posterior) half of one sclerotome fuses with the rostral (anterior) half of the adjacent one to form each vertebra. From their initial location within the somite, the sclerotome cells migrate medially towards the notochord. These cells meet the sclerotome cells from the other side to form the vertebral body. From this vertebral body, sclerotome cells move dorsally and surround the developing spinal cord, forming the vertebral arch[WP]. + Skeletogenic portion of somites.[AAO] + The vertebrate sclerotome has no equivalent in amphioxus and is a novelty linked with the evolution of the axial skeleton.[well established][VHOG] + part_of somite in XAO + + + AAO:0010571 + AEO:0000212 + EHDAA2:0003439 + EMAPA:31159 + FMA:295652 + NCIT:C34287 + TAO:0001080 + UMLS:C0183176 + VHOG:0000680 + XAO:0000397 + ZFA:0001080 + sclerotomes + uberon + sclerotomus + UBERON:0003089 + + + + sclerotome + http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png + + + + + + EHDAA2 + + + + + + EHDAA2 + + + + + + + + + + + ZFA + + + + + Ventral somitic compartment that is a precursor of the axial skeleton[XAO]. Sclerotomes eventually differentiate into the vertebrae and most of the skull. The caudal (posterior) half of one sclerotome fuses with the rostral (anterior) half of the adjacent one to form each vertebra. From their initial location within the somite, the sclerotome cells migrate medially towards the notochord. These cells meet the sclerotome cells from the other side to form the vertebral body. From this vertebral body, sclerotome cells move dorsally and surround the developing spinal cord, forming the vertebral arch[WP]. + + + XB:curator + + + + + Skeletogenic portion of somites.[AAO] + 2012-06-20 + AAO:0010571 + AAO + AAO:EJS + + + + + The vertebrate sclerotome has no equivalent in amphioxus and is a novelty linked with the evolution of the axial skeleton.[well established][VHOG] + 2012-09-17 + VHOG:0000680 + VHOG + + DOI:10.1073/pnas.97.9.4449 Shimeld SM and Holland PW. Vertebrate innovations. PNAS (2000) + + + + + part_of somite in XAO + XAO + + + + + UMLS:C0183176 + ncithesaurus:Sclerotome + + + + + sclerotomes + TAO:0001080 + + + + + + sclerotomus + + + + + + + + + + + + + + + + + + + neural crest cells (NCCs) originating in the anterior part of the developing embryo and residing between the mid-diencephalon and the forming hindbrain; cranial NCCs migrate dorsolaterally to form the craniofacial mesenchyme that differentiates into various craniofacial cartilages and bones, cranial neurons, glia, and connective tissues of the face; these cells enter the pharyngeal pouches and arches where they give rise to thymic cells, bones of the middle ear and jaw (mandible), and the odontoblasts of the tooth primordia; like their counterparts in the trunk, cranial NCCs also contribute to the developing peripheral nervous system, along with the pigmented cell (i.e. melanocyte) lineage. + Anterior most portion of the neural crest. Migrates in three highly conserved streams: mandibular, hyoid and branchial.[AAO] + Neural crest that is part of the head.[TAO] + We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG] + + AAO:0010580 + EFO:0003645 + EHDAA2:0004420 + EMAPA:16091 + TAO:0001194 + VHOG:0000063 + XAO:0001001 + ZFA:0001194 + CNC + cephalic neural crest + cranial NCC population + head NCC population + uberon + crista neuralis cranialis + head crest + head neural crest + UBERON:0003099 + + + + cranial neural crest + + + + + neural crest cells (NCCs) originating in the anterior part of the developing embryo and residing between the mid-diencephalon and the forming hindbrain; cranial NCCs migrate dorsolaterally to form the craniofacial mesenchyme that differentiates into various craniofacial cartilages and bones, cranial neurons, glia, and connective tissues of the face; these cells enter the pharyngeal pouches and arches where they give rise to thymic cells, bones of the middle ear and jaw (mandible), and the odontoblasts of the tooth primordia; like their counterparts in the trunk, cranial NCCs also contribute to the developing peripheral nervous system, along with the pigmented cell (i.e. melanocyte) lineage. + MGI:anna + + + + + Anterior most portion of the neural crest. Migrates in three highly conserved streams: mandibular, hyoid and branchial.[AAO] + 2012-06-20 + AAO:0010580 + AAO + AAO:EJS + + + + + Neural crest that is part of the head.[TAO] + 2012-08-14 + TAO:0001194 + TAO + ZFIN:curator + + + + + We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG] + 2012-09-17 + VHOG:0000063 + VHOG + + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 + + + + + CNC + XAO:0001001 + + + + + + cephalic neural crest + EMAPA:16091 + + + + + crista neuralis cranialis + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Anatomical structure that overlaps the outer epithelial layer and is adjacent to the space surrounding the organism. + consider obsoleting. See issue/1305 + Organism subdivision which is the collection of anatomical structures on the body surface.[ZFA] + + + + AAO:0010337 + AEO_RETIRED:0000010 + EHDAA2_RETIRED:0003010 + TAO:0000292 + VSAO:0000001 + XAO:0003028 + ZFA:0000292 + galen:SurfaceRegion + anatomical surface feature + uberon + surface feature + surface region + surface structures + UBERON:0003102 + + surface structure + + + + + Anatomical structure that overlaps the outer epithelial layer and is adjacent to the space surrounding the organism. + + + + + + + Organism subdivision which is the collection of anatomical structures on the body surface.[ZFA] + 2012-08-14 + TAO:0000292 + TAO + ZFIN:curator + + + + + anatomical surface feature + EHDAA2:0003010 + + + + + surface structures + ZFA:0000292 + + + + + + + + + + Anatomical structure that has as its parts two or more multi-tissue structures of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona fide boundaries from other distinct anatomical structures of different types. + this class was introduced for consistency with CARO. However, in this ontology we typically classify organs directly under 'organ' rather than subdividing into compound and simple organs + AAO:0010015 + AEO:0000024 + BILA:0000024 + CARO:0000024 + EHDAA2:0003024 + HAO:0000024 + TADS:0000598 + TAO:0000496 + TGMA:0001837 + VHOG:0001723 + XAO:0003041 + ZFA:0000496 + uberon + organ + UBERON:0003103 + + + compound organ + + + + + Anatomical structure that has as its parts two or more multi-tissue structures of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona fide boundaries from other distinct anatomical structures of different types. + CARO:0000024 + + + + + + + + + Portion of tissue composed of mesenchymal cells (motile cells that develop from epthelia via an epithelial to mesenchymal transition) and surrounding extracellular material. Mesenchyme has different embryological origins in different metazoan taxa - in many invertebrates it derives in whole or part from ectoderm. In vertebrates it derives largely from mesoderm, and sometimes the terms are used interchangeably, e.g. lateral plate mesoderm/mesenchyme. + the relationship to mesoderm is weaker than develops_from in order to have classes such as 'head mesenchyme from mesoderm' make sense + A mesh-like cell arrangement, less compact than an epithelium. Kimmel et al, 1995.[TAO] + Portion of tissue consisting of loosely organized undifferentiated mesodermal cells that give rise to such structures as connective tissues, blood, lymphatics, bone, and cartilage.[AAO] + mesenchymal + + + AAO:0010427 + AEO:0000145 + BTO:0001393 + CALOHA:TS-0620 + EHDAA2:0003145 + EV:0100007 + NCIT:C13301 + TAO:0000393 + UMLS:C0162415 + VHOG:0000170 + XAO:0003046 + ZFA:0000393 + mesenchymal tissue + mesenchyme tissue + portion of mesenchymal tissue + portion of mesenchyme tissue + uberon + mesenchyma + UBERON:0003104 + + + + mesenchyme + http://upload.wikimedia.org/wikipedia/commons/f/f4/Mesenchymal_Stem_Cell.jpg + + + + + Portion of tissue composed of mesenchymal cells (motile cells that develop from epthelia via an epithelial to mesenchymal transition) and surrounding extracellular material. Mesenchyme has different embryological origins in different metazoan taxa - in many invertebrates it derives in whole or part from ectoderm. In vertebrates it derives largely from mesoderm, and sometimes the terms are used interchangeably, e.g. lateral plate mesoderm/mesenchyme. + + + + + + + + A mesh-like cell arrangement, less compact than an epithelium. Kimmel et al, 1995.[TAO] + 2012-08-14 + TAO:0000393 + TAO + ZFIN:curator + + + + + Portion of tissue consisting of loosely organized undifferentiated mesodermal cells that give rise to such structures as connective tissues, blood, lymphatics, bone, and cartilage.[AAO] + 2012-06-20 + AAO:0010427 + AAO + AAO:EJS + + + + + UMLS:C0162415 + ncithesaurus:Mesenchyme + + + + + mesenchyma + + + + + + + + + + + + + + + + + Upper portion of the skull that excludes the mandible (when present in the organism). + cranial + the inclusion of the FMA class here is probably not quite correct, as this class includes as parts sutures, whereas this is not part of the bones of the cranium + The term cranium can be ambiguous, in that it can refer to the neurocranium, or the neurocranium and the Facial skeleton + + + BTO:0001328 + EFO:0000831 + EHDAA:6029 + EMAPA:17680 + FMA:71325 + MA:0000316 + MAT:0000340 + MIAA:0000340 + OpenCyc:Mx4rvVlEyJwpEbGdrcN5Y29ycA + VHOG:0000334 + bones of cranium + ossa cranii + set of bones of cranium + skull minus mandible + upper part of skull + uberon + calvarium + epicranial plate + skeletal system of head + UBERON:0003128 + + + + + cranium + + + + + + FMA-inferred + + + + + Upper portion of the skull that excludes the mandible (when present in the organism). + + + + + + + the inclusion of the FMA class here is probably not quite correct, as this class includes as parts sutures, whereas this is not part of the bones of the cranium + FMA + + + + + The term cranium can be ambiguous, in that it can refer to the neurocranium, or the neurocranium and the Facial skeleton + WP + + + + + bones of cranium + FMA:71325 + + + + + ossa cranii + FMA:71325 + FMA:TA + + + + + + set of bones of cranium + FMA:71325 + + + + + calvarium + BTO:0001328 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Anatomical structure that is part of the head consisting entirely of cranium and mandible[WP]. + + in FMA the skull is divided into orbit, neurocranium (8 parts), viscerocranium (26 parts). Here we have a separate overlapping division into cranium and mandible. + in many ontologies, the structure called the cranium is inclusive of the mandible/lower jaw skeleton + A skull that is missing a mandible is only a cranium; this is the source of a very commonly made error in terminology. Those animals having skulls are called craniates + + + + BTO:0001295 + CALOHA:TS-2344 + EHDAA2:0000325 + EMAPA:17680 + FMA:46565 + GAID:82 + MESH:D012886 + NCIT:C12789 + OpenCyc:Mx4rvVjOsZwpEbGdrcN5Y29ycA + UMLS:C0037303 + WikipediaCategory:Skull + galen:Skull + uberon + cranial skeleton + skeletal system of head + UBERON:0003129 + + + skull + + + + + + FMA + + + + + Anatomical structure that is part of the head consisting entirely of cranium and mandible[WP]. + + + + + + + + in FMA the skull is divided into orbit, neurocranium (8 parts), viscerocranium (26 parts). Here we have a separate overlapping division into cranium and mandible. + FMA + + + + + A skull that is missing a mandible is only a cranium; this is the source of a very commonly made error in terminology. Those animals having skulls are called craniates + WP + + + + + UMLS:C0037303 + ncithesaurus:Skull + + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of a lower jaw [Automatically generated definition]. + EHDAA2:0001019 + EHDAA:7999 + EMAPA:35516 + VHOG:0000802 + epithelial tissue of lower jaw + epithelial tissue of ventral mandibular arch + epithelium of ventral mandibular arch + lower jaw epithelial tissue + lower jaw epithelium + ventral mandibular arch epithelial tissue + ventral mandibular arch epithelium + uberon + UBERON:0003236 + epithelium of lower jaw + + + + + An epithelium that is part of a lower jaw [Automatically generated definition]. + OBOL:automatic + + + + + epithelial tissue of lower jaw + OBOL:automatic + + + + + epithelial tissue of ventral mandibular arch + OBOL:automatic + + + + + epithelium of ventral mandibular arch + OBOL:automatic + + + + + lower jaw epithelial tissue + OBOL:automatic + + + + + lower jaw epithelium + OBOL:automatic + + + + + ventral mandibular arch epithelial tissue + OBOL:automatic + + + + + ventral mandibular arch epithelium + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + An endoderm that is part of a foregut [Automatically generated definition]. + TODO - check + EHDAA2:0004568 + EHDAA:524 + foregut endoderm + uberon + UBERON:0003258 + endoderm of foregut + + + + + An endoderm that is part of a foregut [Automatically generated definition]. + OBOL:automatic + + + + + foregut endoderm + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A subdivision of the skeleton that corresponds to the lower part of the mouth. The lower jaw skeleton includes the following elements, when present: lower jaw teeth, the mandible and other lower jaw bones, and Meckel's cartilage. + The ventral portion of the first pharyngeal arch, comprising the lower jaw.[TAO] + The jaw joint of all jawed vertebrates, except for mammals, involves the quadrate and articular bones, or the posterior ends of the palatoquadrate and mandibular cartilages; A correlate of the conversion of the articular and quadrate bones to the malleus and incus is that all adult mammals have a jaw joint that lies between the dentary of the lower jaw and the squamosal bone of the skull roof.[well established][VHOG] + Inclusion of the FMA class 'lower jaw' is debatable - this mostly corresponds to the lower jaw skeleton (with 'maxillary part of mouth' corresponding to the upper jaw region); however, the FMA class also includes gingiva. See also: https://github.com/obophenotype/mouse-anatomy-ontology/issues/102 + lower jaw + mandible + AAO:0000274 + EHDAA2:0004606 + EHDAA:8005 + EMAPA:17906 + EMAPA:17910 + FMA:54398 + MA:0001906 + TAO:0001273 + VHOG:0000428 + XAO:0003084 + ZFA:0001273 + lower jaw skeleton + uberon + mandibles + mandibular series + UBERON:0003278 + + skeleton of lower jaw + + + + + + + + + + + EHDAA2 + + + + + + + + + + + + + + + + VHOG-modified + + + + + A subdivision of the skeleton that corresponds to the lower part of the mouth. The lower jaw skeleton includes the following elements, when present: lower jaw teeth, the mandible and other lower jaw bones, and Meckel's cartilage. + + + + + + The ventral portion of the first pharyngeal arch, comprising the lower jaw.[TAO] + 2012-08-14 + TAO:0001273 + TAO + ZFIN:curator + + + + + The jaw joint of all jawed vertebrates, except for mammals, involves the quadrate and articular bones, or the posterior ends of the palatoquadrate and mandibular cartilages; A correlate of the conversion of the articular and quadrate bones to the malleus and incus is that all adult mammals have a jaw joint that lies between the dentary of the lower jaw and the squamosal bone of the skull roof.[well established][VHOG] + 2012-09-17 + VHOG:0000428 + VHOG + + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.241 and p.101 + + + + + Inclusion of the FMA class 'lower jaw' is debatable - this mostly corresponds to the lower jaw skeleton (with 'maxillary part of mouth' corresponding to the upper jaw region); however, the FMA class also includes gingiva. See also: https://github.com/obophenotype/mouse-anatomy-ontology/issues/102 + FMA + + + + + lower jaw + MA:0001906 + + + + + lower jaw + ZFA:0001273 + + + + + mandible + ZFA:0001273 + + + + + lower jaw skeleton + AAO:0000274 + + + + + mandibles + TAO:0001273 + + + + + + mandibular series + ZFA:0001273 + + + + + + + + + + + + + + + + + + + + + + + + + + A gland that is part of a foregut [Automatically generated definition]. + EHDAA2:0000567 + EHDAA:950 + EMAPA:16557 + VHOG:0000650 + foregut gland + uberon + UBERON:0003294 + gland of foregut + + + + + A gland that is part of a foregut [Automatically generated definition]. + OBOL:automatic + + + + + foregut gland + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + Racemose mucous glands beneath the mucous membrane of the pharynx. + BTO:0004849 + EHDAA2:0001461 + EHDAA:2967 + FMA:55075 + pharynx gland + uberon + glandulae pharyngeae + UBERON:0003295 + + pharyngeal gland + + + + + + + + + + + BTO + + + + + Racemose mucous glands beneath the mucous membrane of the pharynx. + + + + + + pharynx gland + EHDAA2:0001461 + + + + + glandulae pharyngeae + BTO:0004849 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any gland that is part of the diencephalon. Examples: pineal gland, neurohypophysis. + EHDAA2:0000395 + EHDAA:4475 + EMAPA:16897 + VHOG:0000653 + diencephalon gland + interbrain gland + uberon + UBERON:0003296 + gland of diencephalon + + + + + Any gland that is part of the diencephalon. Examples: pineal gland, neurohypophysis. + + + + + + diencephalon gland + OBOL:automatic + + + + + interbrain gland + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A gland that is part of a integumental system [Automatically generated definition]. + EHDAA2:0000837 + EHDAA:6522 + EMAPA:17758 + MA:0000144 + VHOG:0000654 + integumental gland + integumental system gland + integumentary gland + uberon + UBERON:0003297 + gland of integumental system + + + + + A gland that is part of a integumental system [Automatically generated definition]. + OBOL:automatic + + + + + integumental gland + + + + + + integumental system gland + + + + + + integumentary gland + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A blood island that is part of a mesoderm. + in EHDAA2, gives rise to blood and dorsal aorta + UBERON:0003305 + EHDAA2:0003241 + EHDAA:170 + EMAPA:16115 + mesoderm blood islands + uberon + mesenchyme blood island + UBERON:0003304 + mesoderm blood island + + + + + + EHDAA2 + + + + + + + + + + + EHDAA2 + + + + + A blood island that is part of a mesoderm. + OBOL:automatic + + + + + in EHDAA2, gives rise to blood and dorsal aorta + EHDAA2 + + + + + mesoderm blood islands + EHDAA2:0003241 + + + + + + mesenchyme blood island + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Mesenchyme that is part of a developing camera-type eye. + TODO - change mesenchyme relationships to precursor_of + EHDAA2:0000485 + EHDAA:2910 + EMAPA:16673 + VHOG:0001084 + mesenchyme of eye + uberon + UBERON:0003314 + eye mesenchyme + + + + + + + + + + + EHDAA2 + + + + + Mesenchyme that is part of a developing camera-type eye. + OBOL:automatic + + + + + mesenchyme of eye + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Mesenchyme that is part of a developing lower jaw [Automatically generated definition]. + EHDAA2:0001024 + EHDAA:8003 + EMAPA:17916 + VHOG:0001069 + lower jaw mesenchyme + mesenchyme of ventral mandibular arch + ventral mandibular arch mesenchyme + uberon + UBERON:0003324 + mesenchyme of lower jaw + + + + + + + + + + + EHDAA2 + + + + + Mesenchyme that is part of a developing lower jaw [Automatically generated definition]. + OBOL:automatic + + + + + lower jaw mesenchyme + OBOL:automatic + + + + + mesenchyme of ventral mandibular arch + OBOL:automatic + + + + + ventral mandibular arch mesenchyme + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A mucosa that is part of a oral opening [Automatically generated definition]. + + EMAPA:26937 + mucosa of oral opening + mucosa of oral part of face + mucosa of organ of oral opening + mucosa of organ of oral part of face + mucosa of organ of oral region + mucosa of organ of subdivision of mouth + mucosa of subdivision of mouth + mucous membrane of oral opening + mucous membrane of oral part of face + mucous membrane of oral region + mucous membrane of subdivision of mouth + oral opening mucosa + oral opening mucosa of organ + oral opening mucous membrane + oral opening organ mucosa + oral part of face mucosa + oral part of face mucosa of organ + oral part of face mucous membrane + oral part of face organ mucosa + oral region mucosa + oral region mucosa of organ + oral region mucous membrane + oral region organ mucosa + organ mucosa of oral opening + organ mucosa of oral part of face + organ mucosa of oral region + organ mucosa of subdivision of mouth + subdivision of mouth mucosa + subdivision of mouth mucosa of organ + subdivision of mouth mucous membrane + subdivision of mouth organ mucosa + uberon + UBERON:0003343 + mucosa of oral region + + + + + A mucosa that is part of a oral opening [Automatically generated definition]. + OBOL:automatic + + + + + mucosa of oral opening + OBOL:automatic + + + + + mucosa of oral part of face + OBOL:automatic + + + + + mucosa of organ of oral opening + OBOL:automatic + + + + + mucosa of organ of oral part of face + OBOL:automatic + + + + + mucosa of organ of oral region + OBOL:automatic + + + + + mucosa of organ of subdivision of mouth + OBOL:automatic + + + + + mucosa of subdivision of mouth + OBOL:automatic + + + + + mucous membrane of oral opening + OBOL:automatic + + + + + mucous membrane of oral part of face + OBOL:automatic + + + + + mucous membrane of oral region + OBOL:automatic + + + + + mucous membrane of subdivision of mouth + OBOL:automatic + + + + + oral opening mucosa + OBOL:automatic + + + + + oral opening mucosa of organ + OBOL:automatic + + + + + oral opening mucous membrane + OBOL:automatic + + + + + oral opening organ mucosa + OBOL:automatic + + + + + oral part of face mucosa + OBOL:automatic + + + + + oral part of face mucosa of organ + OBOL:automatic + + + + + oral part of face mucous membrane + OBOL:automatic + + + + + oral part of face organ mucosa + OBOL:automatic + + + + + oral region mucosa + OBOL:automatic + + + + + oral region mucosa of organ + OBOL:automatic + + + + + oral region mucous membrane + OBOL:automatic + + + + + oral region organ mucosa + OBOL:automatic + + + + + organ mucosa of oral opening + OBOL:automatic + + + + + organ mucosa of oral part of face + OBOL:automatic + + + + + organ mucosa of oral region + OBOL:automatic + + + + + organ mucosa of subdivision of mouth + OBOL:automatic + + + + + subdivision of mouth mucosa + OBOL:automatic + + + + + subdivision of mouth mucosa of organ + OBOL:automatic + + + + + subdivision of mouth mucous membrane + OBOL:automatic + + + + + subdivision of mouth organ mucosa + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A layer of epithelial cells on the surface of the mucosa. + BTO:0003752 + uberon + lamina epithelialis mucosa + lamina epithelialis mucosae + UBERON:0003350 + lies on top of lamina propria + epithelium of mucosa + + + + + A layer of epithelial cells on the surface of the mucosa. + BTO:0003752 + + + + + lamina epithelialis mucosa + BTO:0003752 + + + + + lamina epithelialis mucosae + BTO:0003752 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of a pharynx [Automatically generated definition]. + Epithelium lining the pharynx consisting largely of simple columnar epithelium with a short segment (1mm) of stratified squamous epithelium on the ventral side. Chen et al, 2007.[TAO] + BSA:0000112 + BTO:0005240 + EMAPA:16708 + MA:0002725 + RETIRED_EHDAA2:0001460 + TAO:0001174 + XAO:0003202 + ZFA:0001174 + epithelial tissue of pharynx + epithelium of pharynx + pharynx epithelial tissue + pharynx epithelium + uberon + UBERON:0003351 + + pharyngeal epithelium + + + + + + + + + + + ZFA + + + + + + + + + + + ZFA + + + + + An epithelium that is part of a pharynx [Automatically generated definition]. + OBOL:automatic + + + + + Epithelium lining the pharynx consisting largely of simple columnar epithelium with a short segment (1mm) of stratified squamous epithelium on the ventral side. Chen et al, 2007.[TAO] + 2012-08-14 + TAO:0001174 + TAO + ZFIN:curator + + + + + epithelial tissue of pharynx + OBOL:automatic + + + + + epithelium of pharynx + OBOL:automatic + + + + + pharynx epithelial tissue + OBOL:automatic + + + + + pharynx epithelium + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + any of the striated muscles that move the eye and include: superior rectus, inferior rectus, medial rectus, lateral rectus, superior oblique, inferior oblique, retractor bulbi + Not clear if we need this and intra-ocular muscle. See issue #331. MA includes ciliary and iris smooth muscle + EMAPA:18807 + MA:0001268 + ocular smooth muscle + uberon + UBERON:0003386 + + smooth muscle of eye + + + + + any of the striated muscles that move the eye and include: superior rectus, inferior rectus, medial rectus, lateral rectus, superior oblique, inferior oblique, retractor bulbi + MGI:cwg + MP:0005247 + + + + + ocular smooth muscle + MA:0001268 + + + + + + + + + + + + + + + + + + + + + + + + + + A mesothelium that is part of a pericardium [Automatically generated definition]. + RETIRED_EHDAA2:0001436 + cavity of pericardial sac meso-epithelium + cavity of pericardial sac mesothelium + meso-epithelium of cavity of pericardial sac + meso-epithelium of pericardial cavity + mesothelium of cavity of pericardial sac + pericardial cavity meso-epithelium + pericardial cavity mesothelium + uberon + UBERON:0003388 + mesothelium of pericardial cavity + + + + + A mesothelium that is part of a pericardium [Automatically generated definition]. + OBOL:automatic + + + + + cavity of pericardial sac meso-epithelium + OBOL:automatic + + + + + cavity of pericardial sac mesothelium + OBOL:automatic + + + + + meso-epithelium of cavity of pericardial sac + OBOL:automatic + + + + + meso-epithelium of pericardial cavity + OBOL:automatic + + + + + mesothelium of cavity of pericardial sac + OBOL:automatic + + + + + pericardial cavity meso-epithelium + OBOL:automatic + + + + + pericardial cavity mesothelium + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + A gland that is part of a digestive tract [Automatically generated definition]. + EMAPA:18815 + MA:0003202 + digestive tract gland + gland of digestive tract + gland of lower gastrointestinal tract + gut gland + lower gastrointestinal tract gland + uberon + UBERON:0003408 + gland of digestive tract + + + + + A gland that is part of a digestive tract [Automatically generated definition]. + OBOL:automatic + + + + + digestive tract gland + OBOL:automatic + + + + + gland of digestive tract + OBOL:automatic + + + + + gland of lower gastrointestinal tract + OBOL:automatic + + + + + gut gland + MA:0003202 + + + + + lower gastrointestinal tract gland + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + An adipose tissue that is part of a dermis [Automatically generated definition]. + MA:0000798 + adipose tissue of dermis + dermis fat tissue + dermis fatty tissue + fat tissue of dermis + fatty tissue of dermis + uberon + UBERON:0003426 + + dermis adipose tissue + + + + + An adipose tissue that is part of a dermis [Automatically generated definition]. + OBOL:automatic + + + + + adipose tissue of dermis + OBOL:automatic + + + + + dermis fat tissue + OBOL:automatic + + + + + dermis fatty tissue + OBOL:automatic + + + + + fat tissue of dermis + OBOL:automatic + + + + + fatty tissue of dermis + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + An artery that is part of a respiratory system [Automatically generated definition]. + EMAPA:37569 + MA:0001804 + uberon + UBERON:0003469 + respiratory system artery + + + + + An artery that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + + + + + EMAPA:37569 + MA:th + + + + + + + + + + + + + + + + + + + + + An artery that is part of a thoracic cavity[cjm]. + in MA, aorta is classified here - but this is problematic because the abdominal aorta is not in the thoracic cavity + EMAPA:37241 + MA:0001902 + MESH:D013895 + uberon + thoracic artery + UBERON:0003473 + thoracic cavity artery + + + + + An artery that is part of a thoracic cavity[cjm]. + + + + + + in MA, aorta is classified here - but this is problematic because the abdominal aorta is not in the thoracic cavity + MA + + + + + EMAPA:37241 + MA:th + + + + + thoracic artery + MESH:A07.231.114.891 + + + + + + + + + + + + + + + + + + + + + + + + + + A vein that is part of a respiratory system [Automatically generated definition]. + EMAPA:37584 + MA:0001809 + MA:0001810 + apparatus respiratorius vein + respiratory system vein + vein of apparatus respiratorius + vein of respiratory system + uberon + UBERON:0003476 + respiratory system venous blood vessel + + + + + A vein that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + + + + + EMAPA:37584 + MA:th + + + + + apparatus respiratorius vein + OBOL:automatic + + + + + respiratory system vein + OBOL:automatic + + + + + vein of apparatus respiratorius + OBOL:automatic + + + + + vein of respiratory system + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + The inferior labial vein is the vein receiving blood from the lower lip. + + + EMAPA:37202 + FMA:52541 + MA:0002253 + inferior labial vein + lower lip vein + vena labialis inferior + uberon + venae labiales inferiores + UBERON:0003478 + vein of lower lip + http://upload.wikimedia.org/wikipedia/commons/8/8c/Gray557.png + + + + + The inferior labial vein is the vein receiving blood from the lower lip. + + + + + + EMAPA:37202 + MA:th + + + + + inferior labial vein + FMA:52541 + + + + + lower lip vein + OBOL:automatic + + + + + vena labialis inferior + + + + + + venae labiales inferiores + + + + + + + + + + + + + + + + + + + + + + + A vein that is part of a thoracic cavity [Automatically generated definition]. + EMAPA:37242 + MA:0001903 + cavity of chest vein + cavity of thorax vein + chest cavity vein + pectoral cavity vein + vein of cavity of chest + vein of cavity of thorax + vein of chest cavity + vein of pectoral cavity + vein of thoracic cavity + uberon + UBERON:0003479 + thoracic cavity vein + + + + + A vein that is part of a thoracic cavity [Automatically generated definition]. + OBOL:automatic + + + + + EMAPA:37242 + MA:th + + + + + cavity of chest vein + OBOL:automatic + + + + + cavity of thorax vein + OBOL:automatic + + + + + chest cavity vein + OBOL:automatic + + + + + pectoral cavity vein + OBOL:automatic + + + + + vein of cavity of chest + OBOL:automatic + + + + + vein of cavity of thorax + OBOL:automatic + + + + + vein of chest cavity + OBOL:automatic + + + + + vein of pectoral cavity + OBOL:automatic + + + + + vein of thoracic cavity + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + An endothelium of capillary that is part of a respiratory system [Automatically generated definition]. + EMAPA:37575 + MA:0001808 + apparatus respiratorius blood capillary endothelium + apparatus respiratorius capillary endothelium + apparatus respiratorius capillary vessel endothelium + apparatus respiratorius endothelium of blood capillary + apparatus respiratorius endothelium of capillary + apparatus respiratorius endothelium of capillary vessel + blood capillary endothelium of apparatus respiratorius + blood capillary endothelium of respiratory system + capillary endothelium of apparatus respiratorius + capillary endothelium of respiratory system + capillary vessel endothelium of apparatus respiratorius + capillary vessel endothelium of respiratory system + endothelium of blood capillary of apparatus respiratorius + endothelium of blood capillary of respiratory system + endothelium of capillary of apparatus respiratorius + endothelium of capillary of respiratory system + endothelium of capillary vessel of apparatus respiratorius + endothelium of capillary vessel of respiratory system + respiratory system blood capillary endothelium + respiratory system capillary vessel endothelium + respiratory system endothelium of blood capillary + respiratory system endothelium of capillary + respiratory system endothelium of capillary vessel + uberon + UBERON:0003489 + respiratory system capillary endothelium + + + + + + + + + + + true + + + + + + An endothelium of capillary that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + + + + + EMAPA:37575 + MA:th + + + + + apparatus respiratorius blood capillary endothelium + OBOL:automatic + + + + + apparatus respiratorius capillary endothelium + OBOL:automatic + + + + + apparatus respiratorius capillary vessel endothelium + OBOL:automatic + + + + + apparatus respiratorius endothelium of blood capillary + OBOL:automatic + + + + + apparatus respiratorius endothelium of capillary + OBOL:automatic + + + + + apparatus respiratorius endothelium of capillary vessel + OBOL:automatic + + + + + blood capillary endothelium of apparatus respiratorius + OBOL:automatic + + + + + blood capillary endothelium of respiratory system + OBOL:automatic + + + + + capillary endothelium of apparatus respiratorius + OBOL:automatic + + + + + capillary endothelium of respiratory system + OBOL:automatic + + + + + capillary vessel endothelium of apparatus respiratorius + OBOL:automatic + + + + + capillary vessel endothelium of respiratory system + OBOL:automatic + + + + + endothelium of blood capillary of apparatus respiratorius + OBOL:automatic + + + + + endothelium of blood capillary of respiratory system + OBOL:automatic + + + + + endothelium of capillary of apparatus respiratorius + OBOL:automatic + + + + + endothelium of capillary of respiratory system + OBOL:automatic + + + + + endothelium of capillary vessel of apparatus respiratorius + OBOL:automatic + + + + + endothelium of capillary vessel of respiratory system + OBOL:automatic + + + + + respiratory system blood capillary endothelium + OBOL:automatic + + + + + respiratory system capillary vessel endothelium + OBOL:automatic + + + + + respiratory system endothelium of blood capillary + OBOL:automatic + + + + + respiratory system endothelium of capillary + OBOL:automatic + + + + + respiratory system endothelium of capillary vessel + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + A venule that is part of a respiratory system [Automatically generated definition]. + EMAPA:37587 + MA:0001813 + apparatus respiratorius venule + venule of apparatus respiratorius + venule of respiratory system + uberon + UBERON:0003494 + respiratory system venule + + + + + A venule that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + + + + + EMAPA:37587 + MA:th + + + + + apparatus respiratorius venule + OBOL:automatic + + + + + venule of apparatus respiratorius + OBOL:automatic + + + + + venule of respiratory system + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + An arteriole that is part of a respiratory system [Automatically generated definition]. + EMAPA:37568 + MA:0001803 + uberon + UBERON:0003495 + respiratory system arteriole + + + + + + + + + + + true + + + + + + An arteriole that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + + + + + EMAPA:37568 + MA:th + + + + + + + + + + + + + + + + + + + + + + + + + + A blood vessel that is part of a head [Automatically generated definition]. + + EMAPA:36610 + MA:0000575 + adult head blood vessel + blood vessel of adult head + blood vessel of head + uberon + UBERON:0003496 + head blood vessel + + + + + + + + + + + true + + + + + + A blood vessel that is part of a head [Automatically generated definition]. + OBOL:automatic + + + + + adult head blood vessel + OBOL:automatic + + + + + blood vessel of adult head + OBOL:automatic + + + + + blood vessel of head + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + A blood vessel that is part of a heart [Automatically generated definition]. + EMAPA:35397 + MA:0002483 + blood vessel of heart + uberon + cardiac blood vessel + UBERON:0003498 + + heart blood vessel + + + + + A blood vessel that is part of a heart [Automatically generated definition]. + OBOL:automatic + + + + + blood vessel of heart + OBOL:automatic + + + + + cardiac blood vessel + EMAPA:35397 + + + + + + + + + + + + + + + + + + + + + + + + + + + A blood vessel that is part of a brain [Automatically generated definition]. + EMAPA:35182 + MA:0002769 + blood vessel of brain + uberon + UBERON:0003499 + + brain blood vessel + + + + + A blood vessel that is part of a brain [Automatically generated definition]. + OBOL:automatic + + + + + blood vessel of brain + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + A blood vessel that is part of a cornea [Automatically generated definition]. + follow up on tracker item + + EMAPA:36611 + MA:0001241 + blood vessel of cornea + cornea blood vessel + uberon + UBERON:0003500 + corneal blood vessel + + + + + A blood vessel that is part of a cornea [Automatically generated definition]. + + + + + + + + + + + + + blood vessel of cornea + OBOL:automatic + + + + + cornea blood vessel + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A blood vessel that is part of a retina [Automatically generated definition]. + + EMAPA:36520 + GAID:509 + MA:0001317 + MESH:D012171 + XAO:0004153 + blood vessel of inner layer of eyeball + blood vessel of retina + blood vessel of tunica interna of eyeball + inner layer of eyeball blood vessel + retinal blood vessel + tunica interna of eyeball blood vessel + uberon + UBERON:0003501 + + retina blood vessel + + + + + A blood vessel that is part of a retina [Automatically generated definition]. + OBOL:automatic + + + + + blood vessel of inner layer of eyeball + OBOL:automatic + + + + + blood vessel of retina + OBOL:automatic + + + + + blood vessel of tunica interna of eyeball + OBOL:automatic + + + + + inner layer of eyeball blood vessel + OBOL:automatic + + + + + retinal blood vessel + OBOL:automatic + + + + + tunica interna of eyeball blood vessel + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A blood vessel that is part of a neck [Automatically generated definition]. + EMAPA:37236 + MA:0000583 + blood vessel of neck + blood vessel of neck (volume) + neck (volume) blood vessel + uberon + UBERON:0003502 + neck blood vessel + + + + + A blood vessel that is part of a neck [Automatically generated definition]. + OBOL:automatic + + + + + EMAPA:37236 + MA:th + + + + + blood vessel of neck + OBOL:automatic + + + + + blood vessel of neck (volume) + OBOL:automatic + + + + + neck (volume) blood vessel + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A blood vessel that is part of a respiratory system [Automatically generated definition]. + EMAPA:35731 + EMAPA:35995 + MA:0001799 + apparatus respiratorius blood vessel + blood vessel of apparatus respiratorius + blood vessel of respiratory system + uberon + UBERON:0003504 + respiratory system blood vessel + + + + + A blood vessel that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + + + + + apparatus respiratorius blood vessel + OBOL:automatic + + + + + blood vessel of apparatus respiratorius + OBOL:automatic + + + + + blood vessel of respiratory system + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A blood vessel that is part of the arterial system. Includes artery, arteriole and aorta. + EMAPA:35144 + MA:0000061 + uberon + UBERON:0003509 + + only in MA - supertype of artery, arteriole, aorta. + arterial blood vessel + + + + + A blood vessel that is part of the arterial system. Includes artery, arteriole and aorta. + + + + + + + + + + + + + + + + + + + + + + + + + + + + A blood vessel that is part of a iris [Automatically generated definition]. + EMAPA:37387 + MA:0001290 + ZFA:0005568 + blood vessel of iris + uberon + UBERON:0003511 + + iris blood vessel + + + + + A blood vessel that is part of a iris [Automatically generated definition]. + OBOL:automatic + + + + + EMAPA:37387 + MA:th + + + + + blood vessel of iris + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A blood vessel that is part of a trunk [Automatically generated definition]. + EMAPA:37237 + MA:0000511 + blood vessel of torso + blood vessel of trunk + torso blood vessel + uberon + UBERON:0003513 + trunk blood vessel + + + + + A blood vessel that is part of a trunk [Automatically generated definition]. + OBOL:automatic + + + + + EMAPA:37237 + MA:th + + + + + blood vessel of torso + OBOL:automatic + + + + + blood vessel of trunk + OBOL:automatic + + + + + torso blood vessel + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A blood vessel that is part of a thoracic cavity [Automatically generated definition]. + EMAPA:37240 + MA:0000554 + blood vessel of cavity of chest + blood vessel of cavity of thorax + blood vessel of chest cavity + blood vessel of pectoral cavity + blood vessel of thoracic cavity + cavity of chest blood vessel + cavity of thorax blood vessel + chest cavity blood vessel + pectoral cavity blood vessel + uberon + UBERON:0003519 + thoracic cavity blood vessel + + + + + A blood vessel that is part of a thoracic cavity [Automatically generated definition]. + OBOL:automatic + + + + + EMAPA:37240 + MA:th + + + + + blood vessel of cavity of chest + OBOL:automatic + + + + + blood vessel of cavity of thorax + OBOL:automatic + + + + + blood vessel of chest cavity + OBOL:automatic + + + + + blood vessel of pectoral cavity + OBOL:automatic + + + + + blood vessel of thoracic cavity + OBOL:automatic + + + + + cavity of chest blood vessel + OBOL:automatic + + + + + cavity of thorax blood vessel + OBOL:automatic + + + + + chest cavity blood vessel + OBOL:automatic + + + + + pectoral cavity blood vessel + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + A capillary that is part of a respiratory system [Automatically generated definition]. + EMAPA:37574 + MA:0001807 + apparatus respiratorius blood capillary + apparatus respiratorius capillary + apparatus respiratorius capillary vessel + blood capillary of apparatus respiratorius + blood capillary of respiratory system + capillary of apparatus respiratorius + capillary of respiratory system + capillary vessel of apparatus respiratorius + capillary vessel of respiratory system + respiratory system blood capillary + respiratory system capillary vessel + uberon + UBERON:0003526 + respiratory system capillary + + + + + A capillary that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + + + + + EMAPA:37574 + MA:th + + + + + apparatus respiratorius blood capillary + OBOL:automatic + + + + + apparatus respiratorius capillary + OBOL:automatic + + + + + apparatus respiratorius capillary vessel + OBOL:automatic + + + + + blood capillary of apparatus respiratorius + OBOL:automatic + + + + + blood capillary of respiratory system + OBOL:automatic + + + + + capillary of apparatus respiratorius + OBOL:automatic + + + + + capillary of respiratory system + OBOL:automatic + + + + + capillary vessel of apparatus respiratorius + OBOL:automatic + + + + + capillary vessel of respiratory system + OBOL:automatic + + + + + respiratory system blood capillary + OBOL:automatic + + + + + respiratory system capillary vessel + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A gray matter that is part of a brain [Automatically generated definition]. + + EMAPA:35184 + MA:0000810 + NCIT:C49333 + UMLS:C1707348 + brain grey matter + brain grey substance + gray matter of brain + grey matter of brain + grey substance of brain + uberon + UBERON:0003528 + brain gray matter + + + + + A gray matter that is part of a brain [Automatically generated definition]. + OBOL:automatic + + + + + UMLS:C1707348 + ncithesaurus:Cerebral_Gray_Matter + + + + + brain grey matter + MA:0000810 + + + + + brain grey substance + OBOL:automatic + + + + + gray matter of brain + OBOL:automatic + + + + + grey matter of brain + OBOL:automatic + + + + + grey substance of brain + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of connective tissue that is part of a head [Automatically generated definition]. + EMAPA:16098 + MA:0000577 + adult head connective tissue + adult head portion of connective tissue + adult head textus connectivus + connective tissue of adult head + connective tissue of head + head portion of connective tissue + head textus connectivus + portion of connective tissue of adult head + portion of connective tissue of head + textus connectivus of adult head + textus connectivus of head + uberon + UBERON:0003566 + head connective tissue + + + + + A portion of connective tissue that is part of a head [Automatically generated definition]. + OBOL:automatic + + + + + adult head connective tissue + OBOL:automatic + + + + + adult head portion of connective tissue + OBOL:automatic + + + + + adult head textus connectivus + OBOL:automatic + + + + + connective tissue of adult head + OBOL:automatic + + + + + connective tissue of head + OBOL:automatic + + + + + head portion of connective tissue + OBOL:automatic + + + + + head textus connectivus + OBOL:automatic + + + + + portion of connective tissue of adult head + OBOL:automatic + + + + + portion of connective tissue of head + OBOL:automatic + + + + + textus connectivus of adult head + OBOL:automatic + + + + + textus connectivus of head + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of connective tissue that is part of a neck [Automatically generated definition]. + EMAPA:37250 + MA:0000585 + connective tissue of neck + connective tissue of neck (volume) + neck (volume) connective tissue + neck (volume) portion of connective tissue + neck (volume) textus connectivus + neck portion of connective tissue + neck textus connectivus + portion of connective tissue of neck + portion of connective tissue of neck (volume) + textus connectivus of neck + textus connectivus of neck (volume) + uberon + UBERON:0003568 + neck connective tissue + + + + + A portion of connective tissue that is part of a neck [Automatically generated definition]. + OBOL:automatic + + + + + EMAPA:37250 + MA:th + + + + + connective tissue of neck + OBOL:automatic + + + + + connective tissue of neck (volume) + OBOL:automatic + + + + + neck (volume) connective tissue + OBOL:automatic + + + + + neck (volume) portion of connective tissue + OBOL:automatic + + + + + neck (volume) textus connectivus + OBOL:automatic + + + + + neck portion of connective tissue + OBOL:automatic + + + + + neck textus connectivus + OBOL:automatic + + + + + portion of connective tissue of neck + OBOL:automatic + + + + + portion of connective tissue of neck (volume) + OBOL:automatic + + + + + textus connectivus of neck + OBOL:automatic + + + + + textus connectivus of neck (volume) + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of connective tissue that is part of a respiratory system [Automatically generated definition]. + EMAPA:35968 + EMAPA:35977 + MA:0001814 + apparatus respiratorius connective tissue + apparatus respiratorius portion of connective tissue + apparatus respiratorius textus connectivus + connective tissue of apparatus respiratorius + connective tissue of respiratory system + portion of connective tissue of apparatus respiratorius + portion of connective tissue of respiratory system + respiratory system portion of connective tissue + respiratory system textus connectivus + textus connectivus of apparatus respiratorius + textus connectivus of respiratory system + uberon + UBERON:0003570 + respiratory system connective tissue + + + + + A portion of connective tissue that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + + + + + apparatus respiratorius connective tissue + OBOL:automatic + + + + + apparatus respiratorius portion of connective tissue + OBOL:automatic + + + + + apparatus respiratorius textus connectivus + OBOL:automatic + + + + + connective tissue of apparatus respiratorius + OBOL:automatic + + + + + connective tissue of respiratory system + OBOL:automatic + + + + + portion of connective tissue of apparatus respiratorius + OBOL:automatic + + + + + portion of connective tissue of respiratory system + OBOL:automatic + + + + + respiratory system portion of connective tissue + OBOL:automatic + + + + + respiratory system textus connectivus + OBOL:automatic + + + + + textus connectivus of apparatus respiratorius + OBOL:automatic + + + + + textus connectivus of respiratory system + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of connective tissue that is part of a dermis [Automatically generated definition]. + EMAPA:36509 + MA:0000799 + connective tissue of dermis + dermis portion of connective tissue + dermis textus connectivus + portion of connective tissue of dermis + textus connectivus of dermis + uberon + UBERON:0003585 + + dermis connective tissue + + + + + A portion of connective tissue that is part of a dermis [Automatically generated definition]. + OBOL:automatic + + + + + connective tissue of dermis + OBOL:automatic + + + + + dermis portion of connective tissue + OBOL:automatic + + + + + dermis textus connectivus + OBOL:automatic + + + + + portion of connective tissue of dermis + OBOL:automatic + + + + + textus connectivus of dermis + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of connective tissue that is part of a trunk [Automatically generated definition]. + EMAPA:37252 + MA:0000513 + connective tissue of torso + connective tissue of trunk + portion of connective tissue of torso + portion of connective tissue of trunk + textus connectivus of torso + textus connectivus of trunk + torso connective tissue + torso portion of connective tissue + torso textus connectivus + trunk portion of connective tissue + trunk textus connectivus + uberon + UBERON:0003586 + trunk connective tissue + + + + + A portion of connective tissue that is part of a trunk [Automatically generated definition]. + OBOL:automatic + + + + + EMAPA:37252 + MA:th + + + + + connective tissue of torso + OBOL:automatic + + + + + connective tissue of trunk + OBOL:automatic + + + + + portion of connective tissue of torso + OBOL:automatic + + + + + portion of connective tissue of trunk + OBOL:automatic + + + + + textus connectivus of torso + OBOL:automatic + + + + + textus connectivus of trunk + OBOL:automatic + + + + + torso connective tissue + OBOL:automatic + + + + + torso portion of connective tissue + OBOL:automatic + + + + + torso textus connectivus + OBOL:automatic + + + + + trunk portion of connective tissue + OBOL:automatic + + + + + trunk textus connectivus + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of connective tissue that is part of a thoracic cavity [Automatically generated definition]. + EMAPA:37255 + MA:0000555 + cavity of chest connective tissue + cavity of chest portion of connective tissue + cavity of chest textus connectivus + cavity of thorax connective tissue + cavity of thorax portion of connective tissue + cavity of thorax textus connectivus + chest cavity connective tissue + chest cavity portion of connective tissue + chest cavity textus connectivus + connective tissue of cavity of chest + connective tissue of cavity of thorax + connective tissue of chest cavity + connective tissue of pectoral cavity + connective tissue of thoracic cavity + pectoral cavity connective tissue + pectoral cavity portion of connective tissue + pectoral cavity textus connectivus + portion of connective tissue of cavity of chest + portion of connective tissue of cavity of thorax + portion of connective tissue of chest cavity + portion of connective tissue of pectoral cavity + portion of connective tissue of thoracic cavity + textus connectivus of cavity of chest + textus connectivus of cavity of thorax + textus connectivus of chest cavity + textus connectivus of pectoral cavity + textus connectivus of thoracic cavity + thoracic cavity portion of connective tissue + thoracic cavity textus connectivus + uberon + UBERON:0003593 + thoracic cavity connective tissue + + + + + A portion of connective tissue that is part of a thoracic cavity [Automatically generated definition]. + OBOL:automatic + + + + + EMAPA:37255 + MA:th + + + + + cavity of chest connective tissue + OBOL:automatic + + + + + cavity of chest portion of connective tissue + OBOL:automatic + + + + + cavity of chest textus connectivus + OBOL:automatic + + + + + cavity of thorax connective tissue + OBOL:automatic + + + + + cavity of thorax portion of connective tissue + OBOL:automatic + + + + + cavity of thorax textus connectivus + OBOL:automatic + + + + + chest cavity connective tissue + OBOL:automatic + + + + + chest cavity portion of connective tissue + OBOL:automatic + + + + + chest cavity textus connectivus + OBOL:automatic + + + + + connective tissue of cavity of chest + OBOL:automatic + + + + + connective tissue of cavity of thorax + OBOL:automatic + + + + + connective tissue of chest cavity + OBOL:automatic + + + + + connective tissue of pectoral cavity + OBOL:automatic + + + + + connective tissue of thoracic cavity + OBOL:automatic + + + + + pectoral cavity connective tissue + OBOL:automatic + + + + + pectoral cavity portion of connective tissue + OBOL:automatic + + + + + pectoral cavity textus connectivus + OBOL:automatic + + + + + portion of connective tissue of cavity of chest + OBOL:automatic + + + + + portion of connective tissue of cavity of thorax + OBOL:automatic + + + + + portion of connective tissue of chest cavity + OBOL:automatic + + + + + portion of connective tissue of pectoral cavity + OBOL:automatic + + + + + portion of connective tissue of thoracic cavity + OBOL:automatic + + + + + textus connectivus of cavity of chest + OBOL:automatic + + + + + textus connectivus of cavity of thorax + OBOL:automatic + + + + + textus connectivus of chest cavity + OBOL:automatic + + + + + textus connectivus of pectoral cavity + OBOL:automatic + + + + + textus connectivus of thoracic cavity + OBOL:automatic + + + + + thoracic cavity portion of connective tissue + OBOL:automatic + + + + + thoracic cavity textus connectivus + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + A skin gland that is part of a camera-type eye [Automatically generated definition]. + EMAPA:37530 + MA:0002451 + camera-type eye skin gland + camera-type eye skin glands + camera-type eye skin glands set + skin gland of camera-type eye + skin gland of vertebrate eye + skin glands of camera-type eye + skin glands of vertebrate eye + skin glands set of camera-type eye + skin glands set of vertebrate eye + vertebrate eye skin gland + vertebrate eye skin glands + vertebrate eye skin glands set + uberon + UBERON:0003605 + + eye skin gland + + + + + A skin gland that is part of a camera-type eye [Automatically generated definition]. + OBOL:automatic + + + + + EMAPA:37530 + MA:th + + + + + camera-type eye skin gland + OBOL:automatic + + + + + camera-type eye skin glands + OBOL:automatic + + + + + camera-type eye skin glands set + OBOL:automatic + + + + + skin gland of camera-type eye + OBOL:automatic + + + + + skin gland of vertebrate eye + OBOL:automatic + + + + + skin glands of camera-type eye + OBOL:automatic + + + + + skin glands of vertebrate eye + OBOL:automatic + + + + + skin glands set of camera-type eye + OBOL:automatic + + + + + skin glands set of vertebrate eye + OBOL:automatic + + + + + vertebrate eye skin gland + OBOL:automatic + + + + + vertebrate eye skin glands + OBOL:automatic + + + + + vertebrate eye skin glands set + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + The type of heart connective tissue found in the endocardial layer that consists mainly of elastic fibers. + MA:0002858 + cardiac elastic tissue + elastic connective tissue of heart + elastic tissue of heart + heart elastic connective tissue + heart textus connectivus elasticus + textus connectivus elasticus of heart + uberon + UBERON:0003610 + + heart elastic tissue + + + + + The type of heart connective tissue found in the endocardial layer that consists mainly of elastic fibers. + MP:0009863 + + + + + cardiac elastic tissue + MP:0009863 + + + + + elastic connective tissue of heart + OBOL:automatic + + + + + elastic tissue of heart + OBOL:automatic + + + + + heart elastic connective tissue + OBOL:automatic + + + + + heart textus connectivus elasticus + OBOL:automatic + + + + + textus connectivus elasticus of heart + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + An elastic tissue that is part of a respiratory system [Automatically generated definition]. + EMAPA:37579 + MA:0001820 + apparatus respiratorius elastic connective tissue + apparatus respiratorius elastic tissue + apparatus respiratorius textus connectivus elasticus + elastic connective tissue of apparatus respiratorius + elastic connective tissue of respiratory system + elastic tissue of apparatus respiratorius + elastic tissue of respiratory system + respiratory system elastic connective tissue + respiratory system textus connectivus elasticus + textus connectivus elasticus of apparatus respiratorius + textus connectivus elasticus of respiratory system + uberon + UBERON:0003611 + respiratory system elastic tissue + + + + + An elastic tissue that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + + + + + EMAPA:37579 + MA:th + + + + + apparatus respiratorius elastic connective tissue + OBOL:automatic + + + + + apparatus respiratorius elastic tissue + OBOL:automatic + + + + + apparatus respiratorius textus connectivus elasticus + OBOL:automatic + + + + + elastic connective tissue of apparatus respiratorius + OBOL:automatic + + + + + elastic connective tissue of respiratory system + OBOL:automatic + + + + + elastic tissue of apparatus respiratorius + OBOL:automatic + + + + + elastic tissue of respiratory system + OBOL:automatic + + + + + respiratory system elastic connective tissue + OBOL:automatic + + + + + respiratory system textus connectivus elasticus + OBOL:automatic + + + + + textus connectivus elasticus of apparatus respiratorius + OBOL:automatic + + + + + textus connectivus elasticus of respiratory system + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + An elastic tissue that is part of a circulatory system [Automatically generated definition]. + MA:0002857 + cardiovascular system elastic connective tissue + cardiovascular system textus connectivus elasticus + circulatory system elastic connective tissue + circulatory system elastic tissue + circulatory system textus connectivus elasticus + elastic connective tissue of cardiovascular system + elastic connective tissue of circulatory system + elastic tissue of cardiovascular system + elastic tissue of circulatory system + textus connectivus elasticus of cardiovascular system + textus connectivus elasticus of circulatory system + uberon + UBERON:0003613 + cardiovascular system elastic tissue + + + + + An elastic tissue that is part of a circulatory system [Automatically generated definition]. + OBOL:automatic + + + + + cardiovascular system elastic connective tissue + OBOL:automatic + + + + + cardiovascular system textus connectivus elasticus + OBOL:automatic + + + + + circulatory system elastic connective tissue + OBOL:automatic + + + + + circulatory system elastic tissue + OBOL:automatic + + + + + circulatory system textus connectivus elasticus + OBOL:automatic + + + + + elastic connective tissue of cardiovascular system + OBOL:automatic + + + + + elastic connective tissue of circulatory system + OBOL:automatic + + + + + elastic tissue of cardiovascular system + OBOL:automatic + + + + + elastic tissue of circulatory system + OBOL:automatic + + + + + textus connectivus elasticus of cardiovascular system + OBOL:automatic + + + + + textus connectivus elasticus of circulatory system + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + Elastic tissue layer that lines a blood vessel layer. + elastic lamina + elastic laminae + EMAPA:36300 + MA:0002856 + blood vessel elastic connective tissue + blood vessel textus connectivus elasticus + elastic connective tissue of blood vessel + elastic tissue of blood vessel + textus connectivus elasticus of blood vessel + vascular elastic lamina + vascular elastic laminae + vascular elastic tissue + uberon + UBERON:0003614 + + blood vessel elastic tissue + + + + + Elastic tissue layer that lines a blood vessel layer. + + + + + + + elastic lamina + MP:0006083 + + + + + elastic laminae + MP:0006083 + + + + + + blood vessel elastic connective tissue + OBOL:automatic + + + + + blood vessel textus connectivus elasticus + OBOL:automatic + + + + + elastic connective tissue of blood vessel + OBOL:automatic + + + + + elastic tissue of blood vessel + OBOL:automatic + + + + + textus connectivus elasticus of blood vessel + OBOL:automatic + + + + + vascular elastic lamina + + + + + + vascular elastic laminae + + + + + + + vascular elastic tissue + MP:0006083 + + + + + + + + + + + + + + + + + + + + + An arterial blood vessel that is part of a respiratory system [Automatically generated definition]. + EMAPA:37565 + MA:0001800 + uberon + UBERON:0003643 + respiratory system arterial blood vessel + + + + + An arterial blood vessel that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + + + + + EMAPA:37565 + MA:th + + + + + + + + + + + + + + + + Portion of tissue in the nervous system which consists of neurons and glial cells, and may also contain parts of the vasculature. + One of the four types of tissue in traditional classifications. Cells forming the brain, spinal cord and peripheral nervous system.[AAO] + FMA definition includes vasculature + + + AAO:0000325 + AEO:0000123 + EHDAA2:0003123 + FMA:9642 + GAID:609 + MESH:D009417 + NCIT:C13052 + OpenCyc:Mx4rVmfYCsQ_QdeM_bFAeS8NRQ + UMLS:C0027757 + nerve tissue + nervous tissue + portion of neural tissue + uberon + UBERON:0003714 + neural tissue + + + + + Portion of tissue in the nervous system which consists of neurons and glial cells, and may also contain parts of the vasculature. + FMA:9642 + + + + + One of the four types of tissue in traditional classifications. Cells forming the brain, spinal cord and peripheral nervous system.[AAO] + 2012-06-20 + AAO:0000325 + AAO + AAO:LAP + + + + + FMA definition includes vasculature + FMA + + + + + UMLS:C0027757 + ncithesaurus:Nervous_Tissue + + + + + nerve tissue + FMA:9642 + + + + + nervous tissue + FMA:9642 + + + + + portion of neural tissue + FMA:9642 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A mucous membrane that lines the mouth. + this is defined as any mucous membrane of the mouth - including palate, lips, uvula, etc. ncit split mouth/oral mucosa into lip and buccal. In future we may split into masticatory/keratinized (gingiva + hard palate) vs lining/non-keratinized (lips, cheeks, floor of mouth, soft palate). FMA distinguishes between mucosa of mouth and region of mouth (the latter including the buccal mucosa) + the mucous membrane epithelium of the mouth. It can be divided into three categories: masticatory, lining, and specialized[Wikipedia:Oral_mucosa]. + + + BTO:0002860 + CALOHA:TS-0716 + EMAPA:26937 + FMA:59660 + GAID:951 + MA:0002794 + MESH:D009061 + NCIT:C77637 + UMLS:C0026639 + mouth mucosa + mouth mucous membrane + mouth organ mucosa + mucosa of mouth + mucous membrane of mouth + oral mucous membrane + oral part of viscerocranial mucosa + tunica mucosa oris + uberon + buccal mucosa + mucosal lining of mouth + oral mucosa + tunica mucosa oris + UBERON:0003729 + + mouth mucosa + + + + + A mucous membrane that lines the mouth. + + + + + + the mucous membrane epithelium of the mouth. It can be divided into three categories: masticatory, lining, and specialized[Wikipedia:Oral_mucosa]. + + + + + + UMLS:C0026639 + ncithesaurus:Oral_Mucosa + + + + + mouth mucosa + FMA:59660 + + + + + mouth mucous membrane + OBOL:accepted + + + + + mouth organ mucosa + OBOL:accepted + + + + + mucosa of mouth + OBOL:accepted + + + + + mucous membrane of mouth + FMA:59660 + + + + + oral part of viscerocranial mucosa + FMA:59660 + + + + + tunica mucosa oris + FMA:59660 + FMA:TA + + + + + + buccal mucosa + GAID:951 + + + + + mucosal lining of mouth + MA:0002794 + + + + + oral mucosa + GAID:951 + + + + + tunica mucosa oris + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any muscle organ that is part of a respiratory system [Automatically generated definition]. + EMAPA:35733 + MA:0001828 + apparatus respiratorius muscle organ + muscle organ of apparatus respiratorius + muscle organ of respiratory system + respiratory system muscle organ + uberon + UBERON:0003831 + respiratory system muscle + + + + + Any muscle organ that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + + + + + apparatus respiratorius muscle organ + OBOL:automatic + + + + + muscle organ of apparatus respiratorius + OBOL:automatic + + + + + muscle organ of respiratory system + OBOL:automatic + + + + + respiratory system muscle organ + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A blood vessel that is part of a thorax [Automatically generated definition]. + EMAPA:37238 + MA:0000558 + blood vessel of thorax + thorax blood vessel + uberon + upper body blood vessel + UBERON:0003834 + thoracic segment blood vessel + + + + + A blood vessel that is part of a thorax [Automatically generated definition]. + OBOL:automatic + + + + + EMAPA:37238 + MA:th + + + + + blood vessel of thorax + OBOL:automatic + + + + + thorax blood vessel + OBOL:automatic + + + + + upper body blood vessel + MA:0000558 + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of connective tissue that is part of a thorax [Automatically generated definition]. + EMAPA:37253 + MA:0000560 + connective tissue of thorax + portion of connective tissue of thorax + textus connectivus of thorax + thorax connective tissue + thorax portion of connective tissue + thorax textus connectivus + uberon + upper body connective tissue + UBERON:0003837 + thoracic segment connective tissue + + + + + A portion of connective tissue that is part of a thorax [Automatically generated definition]. + OBOL:automatic + + + + + EMAPA:37253 + MA:th + + + + + connective tissue of thorax + OBOL:automatic + + + + + portion of connective tissue of thorax + OBOL:automatic + + + + + textus connectivus of thorax + OBOL:automatic + + + + + thorax connective tissue + OBOL:automatic + + + + + thorax portion of connective tissue + OBOL:automatic + + + + + thorax textus connectivus + OBOL:automatic + + + + + upper body connective tissue + MA:0000560 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical space that surrounded_by a neural tube. + (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG] + UBERON:0005713 + AAO:0011073 + EHDAA2:0001269 + EHDAA:2889 + EHDAA:914 + EMAPA:16167 + VHOG:0001119 + XAO:0000252 + cavity of neural tube + lumen of neural tube + neural tube neural lumen + prosencoel + uberon + central lumen + neural lumen + neurocoel + UBERON:0003842 + neural tube lumen + + + + + An anatomical space that surrounded_by a neural tube. + OBOL:automatic + + + + + (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG] + 2012-09-17 + VHOG:0001119 + VHOG + + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28 + + + + + cavity of neural tube + + + + + + lumen of neural tube + + + + + + neural tube neural lumen + EHDAA2:0001269 + + + + + neural lumen + EHDAA:2889 + + + + + neurocoel + VHOG:0001119 + + + + + + + + + + + + + + + + + + + + + + + + + + + A neural crest that has_potential_to_developmentally_contribute_to a midbrain. + We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG] + EFO:0003591 + EHDAA2:0001101 + EHDAA:360 + TAO:0000935 + VHOG:0000796 + ZFA:0000935 + mesencephalic neural crest + neural crest midbrain + uberon + UBERON:0003849 + + + mesencephalic neural crest + + + + + + ZFA + + + + + A neural crest that has_potential_to_developmentally_contribute_to a midbrain. + OBOL:automatic + + + + + We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG] + 2012-09-17 + VHOG:0000796 + VHOG + + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 + + + + + mesencephalic neural crest + ZFA:0000935 + + + + + neural crest midbrain + ZFA:0000935 + + + + + + + + + + + + + + + + + + + + + + + + + + A neural crest that has_potential_to_developmentally_contribute_to a telencephalon. + Cranial neural crest that is part of the telencephalon.[TAO] + We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG] + EFO:0003574 + RETIRED_EHDAA2:0001991 + TAO:0000812 + VHOG:0000799 + ZFA:0000812 + neural crest telencephalon + uberon + UBERON:0003850 + + + telencephalon neural crest + + + + + A neural crest that has_potential_to_developmentally_contribute_to a telencephalon. + OBOL:automatic + + + + + Cranial neural crest that is part of the telencephalon.[TAO] + 2012-08-14 + TAO:0000812 + TAO + ZFIN:curator + + + + + We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG] + 2012-09-17 + VHOG:0000799 + VHOG + + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 + + + + + neural crest telencephalon + ZFA:0000812 + + + + + + + + + + + + + + + + + + + + + + + + + + A neural crest that has_potential_to_developmentally_contribute_to a diencephalon. + We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG] + EFO:0003573 + EHDAA2:0000603 + EMAPA:16518 + TAO:0000811 + VHOG:0000798 + ZFA:0000811 + diencephalic neural crest + future diencephalon neural crest + neural crest diencephalon + neural crest of future diencephalon + uberon + UBERON:0003851 + + diencephalon neural crest + + + + + A neural crest that has_potential_to_developmentally_contribute_to a diencephalon. + OBOL:automatic + + + + + We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG] + 2012-09-17 + VHOG:0000798 + VHOG + + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 + + + + + diencephalic neural crest + ZFA:0000811 + + + + + future diencephalon neural crest + EHDAA2:0000603 + + + + + neural crest diencephalon + ZFA:0000811 + + + + + neural crest of future diencephalon + EMAPA:16518 + + + + + + + + + + + + + + + + + + + + + + + + + + + A neural crest that has_potential_to_developmentally_contribute_to a hindbrain. + Cranial neural crest that is part of the hindbrain.[TAO] + We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG] + EHDAA2:0001628 + EHDAA:362 + EMAPA:35747 + TAO:0007063 + VHOG:0001210 + ZFA:0007063 + neural crest hindbrain + rhombencephalic neural crest + uberon + rhombomere neural crest + UBERON:0003852 + + rhombencephalon neural crest + + + + + + ZFA + + + + + A neural crest that has_potential_to_developmentally_contribute_to a hindbrain. + OBOL:automatic + + + + + Cranial neural crest that is part of the hindbrain.[TAO] + 2012-08-14 + TAO:0007063 + TAO + ZFIN:curator + + + + + We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG] + 2012-09-17 + VHOG:0001210 + VHOG + + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 + + + + + neural crest hindbrain + ZFA:0007063 + + + + + rhombencephalic neural crest + ZFA:0007063 + + + + + rhombomere neural crest + EMAPA:35747 + + + + + + + + + + + + + + + + + + + + + + + + + + A neural crest that has_potential_to_developmentally_contribute_to a spinal cord. + We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...)[well established][VHOG] + EHDAA:696 + EMAPA:16163 + EMAPA:16881 + VHOG:0001006 + neural crest spinal cord + uberon + spinal neural crest + UBERON:0003853 + spinal cord neural crest + + + + + A neural crest that has_potential_to_developmentally_contribute_to a spinal cord. + OBOL:automatic + + + + + We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...)[well established][VHOG] + 2012-09-17 + VHOG:0001006 + VHOG + + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 + + + + + neural crest spinal cord + VHOG:0001006 + + + + + spinal neural crest + VHOG:0001006 + + + + + + + + + + + + + + + + + + + + + + + + + + A neural plate that develops_from a future spinal cord. + Neural plate that is part of the spinal cord. [Bgee_curator][VHOG] + (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...)[well established][VHOG] + FMA:312957 + TAO:0007021 + VHOG:0000439 + ZFA:0007021 + neural plate of spinal cord + uberon + UBERON:0003854 + spinal cord neural plate + + + + + + + + + + + ZFA + + + + + A neural plate that develops_from a future spinal cord. + OBOL:automatic + + + + + Neural plate that is part of the spinal cord. [Bgee_curator][VHOG] + 2012-09-17 + VHOG:0000439 + VHOG + + + + + + (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...)[well established][VHOG] + 2012-09-17 + VHOG:0000439 + VHOG + + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.28 + + + + + neural plate of spinal cord + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical cavity that has the potential to develop into a coelemic cavity lumen. + uberon + body cavity precursor + UBERON:0003886 + + + future coelemic cavity lumen + + + + + An anatomical cavity that has the potential to develop into a coelemic cavity lumen. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + The part of the coelom in the embryo between the somatopleuric and splanchnopleuric mesoderm; the principal body cavities of the trunk (thoracic, abdominal, and pelvic) arise from this embryonic part of the coelom + consider merging with coelom. TODO - add spatial relationships to halves of LPM. Note the OG places XAO and ZFA coelem terms here. editor note: TODO check ZFA, which appears to be a structure present in adults + (...) I regard it unlikely that coeloms of all bilaterian animals are comparable and evolved very early. Considering all these questions, few convincing characters concerning the evolution of body cavities remain to be named. (...) A segmental coelom appears to have evolved at least two times, in Annelida and in Myomerata (Acrania and Craniota).[well established][VHOG] + + + EHDAA:251 + EMAPA:16088 + NCIT:C34195 + UMLS:C1512940 + VHOG:0000316 + somatic coelom + uberon + UBERON:0003887 + + intraembryonic coelom + + + + + + + + + + + Wikipedia + + + + + The part of the coelom in the embryo between the somatopleuric and splanchnopleuric mesoderm; the principal body cavities of the trunk (thoracic, abdominal, and pelvic) arise from this embryonic part of the coelom + MGI:anna + MP:0012187 + + + + + (...) I regard it unlikely that coeloms of all bilaterian animals are comparable and evolved very early. Considering all these questions, few convincing characters concerning the evolution of body cavities remain to be named. (...) A segmental coelom appears to have evolved at least two times, in Annelida and in Myomerata (Acrania and Craniota).[well established][VHOG] + 2012-09-17 + VHOG:0000316 + VHOG + + ISBN:978-0198566694 Schmidt-Rhaesa A, The evolution of organ systems (2007) p.166 + + + + + UMLS:C1512940 + ncithesaurus:Intraembryonic_Coelom + + + + + somatic coelom + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The part of the retina that contains neurons and photoreceptor cells[GO]. + (...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG] + + AAO:0011095 + BTO:0000929 + CALOHA:TS-0685 + EHDAA2:0001253 + EHDAA:4763 + EMAPA:17171 + EMAPA:18590 + FMA:58628 + MA:0000277 + NCIT:C33166 + TAO:0000046 + UMLS:C1518263 + VHOG:0000535 + XAO:0003216 + ZFA:0000046 + neural layer of retina + neural retina + neuroretina + stratum nervosum (retina) + stratum nervosum retinae + uberon + neural retinal epithelium + UBERON:0003902 + + + retinal neural layer + + + + + + + + + + + Bgee:AN + + + + + The part of the retina that contains neurons and photoreceptor cells[GO]. + GO:0003407 + + + + + (...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG] + 2012-09-17 + VHOG:0000535 + VHOG + + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429 + + + + + UMLS:C1518263 + ncithesaurus:Neural_Retina + + + + + neural layer of retina + FMA:58628 + + + + + neural retina + XAO:0003216 + ZFA:0000046 + + + + + neuroretina + ZFA:0000046 + + + + + stratum nervosum (retina) + FMA:58628 + + + + + stratum nervosum retinae + FMA:58628 + FMA:TA + + + + + + neural retinal epithelium + MA:000027 + + + + + + + + + + Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. + contrast with a multi-tissue tube, which has as parts both epithelium, connective tissue, possibly muscle layers + AEO:0000114 + EHDAA2:0003114 + FBbt:00007474 + epithelial or endothelial tube + uberon + UBERON:0003914 + epithelial tube + + + + + Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. + + GO:0060562 + + + + + + + + + + Any endothelium that has the quality of being cylindrical [Automatically generated definition]. + uberon + UBERON:0003915 + endothelial tube + + + + + Any endothelium that has the quality of being cylindrical [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A blood vessel that carries blood from the capillaries toward the heart + EMAPA:35932 + FMA:86188 + MA:0000066 + segment of venous tree organ + venous tree organ segment + uberon + UBERON:0003920 + Compare to: vein + venous blood vessel + + + + + A blood vessel that carries blood from the capillaries toward the heart + + + + + + segment of venous tree organ + FMA:86188 + + + + + venous tree organ segment + FMA:86188 + + + + + + + + + + + + + + + + + + + + + + + + + + A duct that is part of a digestive system [Automatically generated definition]. + TAO:0005162 + ZFA:0005162 + duct of digestive system + duct of gastrointestinal system + gastrointestinal system duct + uberon + UBERON:0003928 + digestive system duct + + + + + A duct that is part of a digestive system [Automatically generated definition]. + OBOL:automatic + + + + + duct of digestive system + OBOL:automatic + + + + + duct of gastrointestinal system + OBOL:automatic + + + + + gastrointestinal system duct + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that lines the lumen of the digestive tract. + Epithelium lining the lumen of the gut.[TAO] + + + BTO:0000956 + EHDAA2:0004567 + EMAPA:32928 + MA:0003201 + NCIT:C12963 + TAO:0005123 + UMLS:C0836205 + XAO:0003200 + ZFA:0005123 + digestive tract epithelial tissue + epithelial tissue of digestive tract + epithelial tissue of gut + epithelium of digestive tract + epithelium of gut + gastrodermis + gut epithelial tissue + gut epithelium + uberon + alimentary tract epithelium + UBERON:0003929 + digestive tract epithelium + + + + + An epithelium that lines the lumen of the digestive tract. + + + + + + Epithelium lining the lumen of the gut.[TAO] + 2012-08-14 + TAO:0005123 + TAO + ZFIN:curator + + + + + UMLS:C0836205 + ncithesaurus:Gut_Epithelium + + + + + digestive tract epithelial tissue + OBOL:automatic + + + + + epithelial tissue of digestive tract + OBOL:automatic + + + + + epithelial tissue of gut + OBOL:automatic + + + + + epithelium of digestive tract + OBOL:automatic + + + + + epithelium of gut + OBOL:automatic + + + + + gastrodermis + BGEE:ANN + NCBITaxon:6073 + + + + + + gut epithelial tissue + OBOL:automatic + + + + + gut epithelium + EHDAA2:0004567 + MA:0003201 + ZFA:0005123 + + + + + alimentary tract epithelium + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The slender connective tissue fiber in the extracellular matrix of skin tissue that is composed of microfibrils and amorphous elastin and is characterized by great elasticity + EMAPA:37841 + cutaneous elastic fiber + dermal elastic fiber + uberon + UBERON:0003967 + + cutaneous elastic tissue + + + + + The slender connective tissue fiber in the extracellular matrix of skin tissue that is composed of microfibrils and amorphous elastin and is characterized by great elasticity + MP:0008418 + + + + + EMAPA:37841 + MA:th + + + + + cutaneous elastic fiber + MP:0008418 + + + + + dermal elastic fiber + MP:0008418 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The connection between the embryo proper and extraembryonic tissues + uberon + UBERON:0004015 + + embryonic-extraembryonic boundary + + + + + The connection between the embryo proper and extraembryonic tissues + MP:0003890 + + + + + + + + + + + + + + + + A transitional population of migrating mesenchymal cells that derive from somites and that will become dermal cells. + Not to be confused with 'dermatome segment of skin'. + + + AAO:0011028 + AEO:0001017 + EHDAA2_RETIRED:0003428 + EHDAA:1719 + EHDAA:1725 + EHDAA:1731 + EHDAA:1737 + EMAPA:32838 + FMA:295656 + NCIT:C61572 + UMLS:C0180383 + XAO:0000220 + cutis plate + dermatomal mesenchyme + uberon + epimere mesoderm + mesenchyma dermatomiale + UBERON:0004016 + + dermatome + http://upload.wikimedia.org/wikipedia/commons/f/f3/Gray64.png + + + + + + AEO + + + + + + + + + + + EHDAA2-abduced + + + + + A transitional population of migrating mesenchymal cells that derive from somites and that will become dermal cells. + AEO:0001017 + AEO:JB + + + + + UMLS:C0180383 + ncithesaurus:Dermatome + + + + + cutis plate + + + + + + dermatomal mesenchyme + + + + + + mesenchyma dermatomiale + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The single layer of epithelial cells that lines the early neural tube and develops into the nervous system and into the neural crest cells + As the cells adjacent to the lumen continue to divide, the migrating cells form a second layer around the original neural tube. This layer becomes progressively thicker as more cells are added to it from the germinal neuroepithelium. This new layer is called the mantle (or intermediate) zone, and the germinal epithelium is now called the ventricular zone (and, later, the ependyma)[NCBIBook:NBK10047] + germinal neuroepithelial layer + germinal neuroepithelium + original neural tube + uberon + UBERON:0004022 + + germinal neuroepithelium + + + + + + NCBIBook:NBK10047 + + + + + The single layer of epithelial cells that lines the early neural tube and develops into the nervous system and into the neural crest cells + + MP:0004261 + + + + + germinal neuroepithelial layer + + + + + + germinal neuroepithelium + NCBIBook:NBK10047 + + + + + original neural tube + NCBIBook:NBK10047 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The transient outer neural tube region that contains the first generated post-mitotic neurons that receive synaptic input from thalamic axons and in turn project axons to the developing cortical plate + The transient fetal subplate zone, together with the marginal zone and the cortical plate, represents the developmental anlage of the mammalian cerebral cortex. It serves as a waiting compartment for growing cortical afferents; its cells are involved in the establishment of pioneering cortical efferent projections and transient fetal circuitry, and apparently have a number of other developmental roles. The subplate zone is a phylogenetically recent structure and it is most developed in the human brain. Subplate neurons are among the first generated neurons in the mammalian cerebral cortex [1]. These neurons disappear during postnatal development and are important in establishing the correct wiring [2][3] and functional maturation [4] of the cerebral cortex. Subplate neurons appear to be selectively sensitive to injury (such as hypoxia) which in humans are associated with motor and cognitive defects + SP + + + + DHBA:10522 + EMAPA:32703 + PBA:294021932 + cerebral cortex subplate + subplate + subplate zone + uberon + UBERON:0004035 + + cortical subplate + + + + + The transient outer neural tube region that contains the first generated post-mitotic neurons that receive synaptic input from thalamic axons and in turn project axons to the developing cortical plate + + + MP:0008440 + + + + + The transient fetal subplate zone, together with the marginal zone and the cortical plate, represents the developmental anlage of the mammalian cerebral cortex. It serves as a waiting compartment for growing cortical afferents; its cells are involved in the establishment of pioneering cortical efferent projections and transient fetal circuitry, and apparently have a number of other developmental roles. The subplate zone is a phylogenetically recent structure and it is most developed in the human brain. Subplate neurons are among the first generated neurons in the mammalian cerebral cortex [1]. These neurons disappear during postnatal development and are important in establishing the correct wiring [2][3] and functional maturation [4] of the cerebral cortex. Subplate neurons appear to be selectively sensitive to injury (such as hypoxia) which in humans are associated with motor and cognitive defects + WP + + + + + SP + BRAINSPAN:BRAINSPAN + + + + + + cerebral cortex subplate + EMAPA:32833 + + + + + subplate zone + DHBA:10522 + + + + + + + + + + + + + + + The region of the developing mammalian cortex that extends between the ventricular zone and the cortical plate (CP); normally, the IZ is a region of tangential migration of cells, and at midgestation, the lower part of the IZ develops into the subventricular zone + IZ + EMAPA:17545 + EMAPA:32712 + uberon + cerebral cortex mantle layer + cerebral cortex mantle zone + cortical mantle layer + UBERON:0004040 + + cortical intermediate zone + + + + + The region of the developing mammalian cortex that extends between the ventricular zone and the cortical plate (CP); normally, the IZ is a region of tangential migration of cells, and at midgestation, the lower part of the IZ develops into the subventricular zone + MP:0008457 + + + + + IZ + BRAINSPAN:BRAINSPAN + + + + + + cerebral cortex mantle layer + EMAPA:17545 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The layer of undifferentiated, proliferating cells that line the neural tube lumen that is the immediate transformation of the germinal neuroepithelium + consider merging with 'ventricular zone'; note that the MA class probably does not belong here, as this is an embryonic structure + The layer of undifferentiated, proliferating cells that line the neural tube lumen + ependymal layer + EMAPA:17152 + EMAPA:35362 + EMAPA_RETIRED:16783 + MA:0003193 + neural tube ependymal layer + neural tube ventricular germinal zone + neural tube ventricular zone + neural tube ependymal zone + uberon + UBERON:0004060 + + neural tube ventricular layer + + + + + + NCBIBook:NBK10047 + + + + + + + + + + + NCBIBook:NBK10047 + + + + + The layer of undifferentiated, proliferating cells that line the neural tube lumen that is the immediate transformation of the germinal neuroepithelium + + MP:0009689 + + + + + The layer of undifferentiated, proliferating cells that line the neural tube lumen + MP:0009689 + + + + + ependymal layer + NCBIBook:NBK10047 + + + + + neural tube ependymal layer + NCBIBook:NBK10047 + + + + + neural tube ventricular germinal zone + NCBIBook:NBK10047 + + + + + neural tube ventricular zone + MP:0009689 + + + + + neural tube ependymal zone + MP:0009689 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The layer of glia and differentiating neurons that forms as a second layer around the germinal neuroepithium; as this develops it comes to lie between the ventricular and marginal layers and includes the basal and alar plates. Develops into neurons and glia forming a gray matter layer. + + EMAPA:17148 + EMAPA:35360 + neural tube intermediate zone + uberon + future brain marginal layer + UBERON:0004061 + + neural tube mantle layer + + + + + + NCBIBook:NBK10047 + + + + + + + + + + + by division + NCBIBook:NBK10047 + + + + + The layer of glia and differentiating neurons that forms as a second layer around the germinal neuroepithium; as this develops it comes to lie between the ventricular and marginal layers and includes the basal and alar plates. Develops into neurons and glia forming a gray matter layer. + + MP:0009690 + + + + + neural tube intermediate zone + + MP:0009690 + + + + + future brain marginal layer + EMAPA:35360 + + + + + + + + + + + + + + + + + + + + + + + + + + + + The outermost layer of the neural tube that consists of axons from the developing mantle layer and will form the white matter + + EMAPA:17151 + neural tube marginal zone + uberon + brain marginal zone + UBERON:0004062 + + neural tube marginal layer + + + + + + + + + + + forms from axons + + + + + The outermost layer of the neural tube that consists of axons from the developing mantle layer and will form the white matter + + MP:0009691 + + + + + neural tube marginal zone + MP:0009691 + + + + + + + + + + + + + + + The subdivision of the face that includes the eye (eyeball plus adnexa such as eyelids) and the orbit of the skull and associated parts of the face such as the eyebrows, if present + note the FMA class is more narrow though, and is more like eye + muscles + vasculature. The FMA also has FMA:72951 orbital part of eye + in HP covers eyelid, eyebrow. + FMA:260119 + content of orbital part of eye + eye region + orbital part of face + uberon + ocular and peri-ocular region + ocular region + orbital content + orbital part of eye + UBERON:0004088 + + orbital region + + + + + The subdivision of the face that includes the eye (eyeball plus adnexa such as eyelids) and the orbit of the skull and associated parts of the face such as the eyebrows, if present + + + + + + in HP covers eyelid, eyebrow. + HP:0000284 + + + + + content of orbital part of eye + FMA:260119 + + + + + eye region + + + + + + orbital part of face + + + + + + orbital content + FMA:260119 + + + + + orbital part of eye + FMA:72951 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + 2 + + + + + 2 + + + + + + + + + + + + + + + + + + Any tube, opening or passage that connects two distinct anatomical spaces. + FMA has both conduit and conduit space. In EHDAA2 this is a surface feature + + + AEO:0000080 + EHDAA2:0003080 + FMA:242873 + foramen + foramina + uberon + opening + ostia + ostium + UBERON:0004111 + anatomical conduit + + + + + Any tube, opening or passage that connects two distinct anatomical spaces. + + + + + + FMA has both conduit and conduit space. In EHDAA2 this is a surface feature + FMA + + + + + foramen + EHDAA2:0003080 + + + + + foramina + + + + + + + ostia + + + + + + + + + + + + + + + + + + + + + + + + + + + A vasculature that is part of a iris [Automatically generated definition]. + ZFA:0005568 + iris blood vessels + iris vascular network + iris vasculature + vascular network of iris + uberon + UBERON:0004118 + + vasculature of iris + + + + + A vasculature that is part of a iris [Automatically generated definition]. + OBOL:automatic + + + + + iris blood vessels + ZFA:0005568 + + + + + iris vascular network + OBOL:automatic + + + + + vascular network of iris + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical structure that develops (entirely or partially) from the endoderm. + Grouping term for query purposes + uberon + UBERON:0004119 + + endoderm-derived structure + + + + + An anatomical structure that develops (entirely or partially) from the endoderm. + + + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical structure that develops (entirely or partially) from the mesoderm. + Grouping term for query purposes + FBbt:00025998 + mesodermal derivative + uberon + UBERON:0004120 + + mesoderm-derived structure + + + + + An anatomical structure that develops (entirely or partially) from the mesoderm. + + + + + + mesodermal derivative + FBbt:00025998 + + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical structure that develops (entirely or partially) from the ectoderm. + Grouping term for query purposes + FBbt:00025990 + ectodermal deriviative + uberon + UBERON:0004121 + + ectoderm-derived structure + + + + + An anatomical structure that develops (entirely or partially) from the ectoderm. + + + + + + ectodermal deriviative + FBbt:00025990 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup[GO]. Portion of tissue that is comprised of neuroepitheium which has pinched off from the anterior neural keel and will form the optic cup[ZFA]. + (...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles.[well established][VHOG] + + + + AAO:0011039 + EHDAA2:0001320 + EMAPA:16540 + FMA:293357 + NCIT:C34236 + TAO:0000050 + UMLS:C0231106 + VHOG:0000165 + XAO:0000228 + ZFA:0000050 + uberon + evagination + eye vesicle + ocular vesicle + optic vesicles + UBERON:0004128 + + + Genes: Six3, Pax6, Rx1 are expressed together in the tip of the neural plate [ISBN:9780878932504 "Developmental Biology"]. Development notes: During subsequent develop- ment, the optic vesicle invaginates and becomes a two-layered structure with an inner neural retina and outer retinal pigment epithelium. As soon as the developing optic vesicle makes contact with the overlying ectoderm, it induces the ectoderm to thicken and form the lens placode [PMID:16496288] + optic vesicle + http://upload.wikimedia.org/wikipedia/commons/e/e0/Gray863.png + + + + + + + + + + + ZFA + + + + + + + + + + + GO-def + + + + + + + + + + + ZFA + + + + + The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup[GO]. Portion of tissue that is comprised of neuroepitheium which has pinched off from the anterior neural keel and will form the optic cup[ZFA]. + + GO:0003404 + + + + + (...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles.[well established][VHOG] + 2012-09-17 + VHOG:0000165 + VHOG + + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429 + + + + + UMLS:C0231106 + ncithesaurus:Optic_Vesicle + + + + + eye vesicle + XAO:0000228 + + + + + ocular vesicle + VHOG:0000165 + + + + + optic vesicles + ZFA:0000050 + + + + + + + + + + + + + + + + + The first recognizable structure derived from the heart field + TODO - check plate vs rudiment vs primordium vs endocardial tube. See XAO + (In vertebrates) The embryonic mesoderm is the source of both the cardiogenic plate, giving rise to the future myocardium as well as the endocardium that will line the system on the inner side.[well established][VHOG] + EHDAA2:0000215 + EMAPA:16106 + VHOG:0000975 + myocardial plate + uberon + cardiac crescent + cardiogenic crescent + heart rudiment + UBERON:0004139 + + cardiogenic plate + + + + + The first recognizable structure derived from the heart field + GO:0003142 + + + + + (In vertebrates) The embryonic mesoderm is the source of both the cardiogenic plate, giving rise to the future myocardium as well as the endocardium that will line the system on the inner side.[well established][VHOG] + 2012-09-17 + VHOG:0000975 + VHOG + + PMID:15611355 Gittenberger-de Groot AC, Bartelings MM, Deruiter MC, Poelmann RE, Basics of cardiac development for the understanding of congenital heart malformations. Pediatric Research (2005) + + + + + myocardial plate + EHDAA2:0000215 + + + + + cardiac crescent + EMAPA:16106 + + + + + cardiogenic crescent + GO:0003142 + + + + + + + + + + + + + + + + + + + + + + + + A specific region of the lateral mesoderm that will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle. + this term denotes the primary heart field; GO:0003128 denotes the superclass of primary and secondary: specific region of the lateral mesoderm into the area which will form the primary beating heart tube[GO:0003138] + XAO:0004185 + first heart field + primary heart field + uberon + FHF + PHF + heart field + UBERON:0004140 + primary heart field + + + + + + + + + + + GO:0003128 + + + + + + + + + + + BGEE:ann + + + + + A specific region of the lateral mesoderm that will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle. + GO:0003138 + GOC:mtg_heart + GOC:rl + + + + + this term denotes the primary heart field; GO:0003128 denotes the superclass of primary and secondary: specific region of the lateral mesoderm into the area which will form the primary beating heart tube[GO:0003138] + GO + + + + + first heart field + XAO:0004185 + + + + + primary heart field + + XAO:0004185 + + + + + FHF + XAO:0004185 + + + + + + PHF + XAO:0004185 + + + + + + heart field + XAO:0004185 + + + + + + + + + + + + + + + + + + + + + + + An epithelial tube that will give rise to the mature heart. + the paired, longitudinal, endothelial-lined channels formed from the cardiogenic mesoderm in embryonic development; angiogenic cell clusters (aka angioblastic cords) located in a horse-shoe shape configuration in the cardiogenic plate coalesce to form the right and left endocardial heart tubes which then fuse in cephalo-caudal direction to form a single primitive heart tube. + AAO:0010411 + EFO:0003526 + EMAPA:32685 + NCIT:C34161 + TAO:0000360 + XAO:0000337 + ZFA:0000360 + embryonic heart tube + endocardial heart tube + endocardial tube + uberon + UBERON:0004141 + + + + heart tube + + + + + + + + + + + ZFA-modified + + + + + An epithelial tube that will give rise to the mature heart. + GO:0003143 + GOC:mtg_heart + + + + + the paired, longitudinal, endothelial-lined channels formed from the cardiogenic mesoderm in embryonic development; angiogenic cell clusters (aka angioblastic cords) located in a horse-shoe shape configuration in the cardiogenic plate coalesce to form the right and left endocardial heart tubes which then fuse in cephalo-caudal direction to form a single primitive heart tube. + MP:0012700 + + + + + embryonic heart tube + GO:0003143 + + + + + endocardial heart tube + MP:0012700 + + + + + endocardial tube + XAO:0000337 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Vein of heart that drains the myocardium + + + + + EHDAA2:0004507 + EMAPA:37137 + FMA:12846 + NCIT:C12878 + NCIT:C12882 + UMLS:C0226654 + UMLS:C0226737 + ZFA:0005814 + galen:CoronaryVein + cardiac vein + coronary vein + heart vein + vein of heart + uberon + coronary vein + UBERON:0004148 + + cardiac vein + + + + + + FMA + + + + + Vein of heart that drains the myocardium + + + + + + EMAPA:37137 + MA:th + + + + + UMLS:C0226654 + ncithesaurus:Cardiac_Vein + + + + + UMLS:C0226737 + ncithesaurus:Coronary_Vein + + + + + cardiac vein + FMA:12846 + + + + + coronary vein + ZFA:0005814 + + + + + heart vein + OBOL:automatic + + + + + vein of heart + OBOL:automatic + + + + + coronary vein + + + + + + + + + + + + + + + + + A cardiac chamber surrounds an enclosed cavity within the heart + + FMA:7095 + OpenCyc:Mx4rmexpjPdAEduAAAAOpmP6tw + chamber of heart + heart chamber + uberon + UBERON:0004151 + generic enough to cover FBbt:00003156 heart chamber but this is a cavity. GO defines it as the cavity. TODO - move subclasses. Note this also includes sinus venosus + cardiac chamber + + + + + A cardiac chamber surrounds an enclosed cavity within the heart + GO:0003205 + + + + + + + + + + + + + + + + + + + + + An embryonic group of progenitor cells that forms from an outpouching of the septum transversum near the venous pole of the heart and gives rise to the epicardium + propepicardial + Proepicardial clusters in Zebrafish form on the pericardial wall, adjacent to the atrioventricular (AV) junction and near the venous pole[ZFA] + EMAPA:36025 + ZFA:0005808 + proepicardial cluster + proepicardial organ + uberon + UBERON:0004160 + proepicardium + + + + + + + + + + + todo check other taxa + + + + + + + + + + + ZFA + + + + + An embryonic group of progenitor cells that forms from an outpouching of the septum transversum near the venous pole of the heart and gives rise to the epicardium + + GO:0003342 + + + + + proepicardial cluster + ZFA:0005808 + + + + + proepicardial organ + ZFIN:ZDB-PUB-080218-16 + + + + + + + + + + + + + + + + + + + + + A thick plate of mesodermal tissue that occupies the space between the thoracic cavity and yolk stalk in the early embryo, forming a transverse partition partially separating the coelomic cavity into thoracic and abdominal portions. It gives rise to the central tendon of the diaphragm[VHOG]. + A thick plate of mesodermal tissue that occupies the space between the thoracic cavity and yolk stalk in the early embryo, forming a transverse partition partially separating the coelomic cavity into thoracic and abdominal portions. It gives rise to the central tendon of the diaphragm. [TFD][VHOG] + In hagfishes a transverse septum extends upward from the ventral body wall posterior to the heart, partly separating an anterior pericardial cavity from a larger peritoneal cavity. (...) These basic relationships have not been modified by urodeles. The small pericardial cavity remains far forward where it is separated by a transverse septum from the principal coelom, which may now be called a pleuroperitoneal cavity because slender lungs are present. (...) The heart (of other tetrapods) is separated from the lungs (and liver if present) by more or less horizontal partitions that have their origin in the embryo as folds on the serous membrane of the right and left lateral body walls. These grow out to join in the midline of the body. They are called lateral mesocardia (birds) or pleuropericardial membranes. Posteriorly they join the transverse septum to form the adult pericardial membrane, or pericardium. (...) In their partitioning of their coelom, embryonic mammals resemble first early fishes (incomplete partition, posterior to heart, consisting of the transverse septum) and then reptiles (pericardium derived from transverse septum and pleuropericardial membranes) Mammals then separate paired pleural cavities from the peritoneal cavity by a diaphragm. The ventral portion of this organ comes from the transverse septum. The dorsal portion is derived from the dorsal mesentery and from still another pair of outgrowths from the lateral body wall, the pleuroperitoneal membranes.[well established][VHOG] + The cranial part of the septum transversum gives rise to the central tendon of the diaphragm and is the origin of the myoblasts that invade the pleuroperitoneal folds resulting in the formation of the muscular diaphragm. The caudal part of the septum transversum is invaded by the hepatic diverticulum which divides within it to form the liver and thus gives rise to the ventral mesentery of the foregut. + in EHDAA2 this is divided into mesenchymal portion and hepatic diverticulum + + + + EHDAA2:0001829 + EHDAA:736 + EMAPA:16318 + FMA:295593 + NCIT:C34296 + UMLS:C0231004 + VHOG:0000019 + transverse septum + uberon + UBERON:0004161 + + septum transversum + + + + + A thick plate of mesodermal tissue that occupies the space between the thoracic cavity and yolk stalk in the early embryo, forming a transverse partition partially separating the coelomic cavity into thoracic and abdominal portions. It gives rise to the central tendon of the diaphragm[VHOG]. + + VHOG:0000019 + + + + + A thick plate of mesodermal tissue that occupies the space between the thoracic cavity and yolk stalk in the early embryo, forming a transverse partition partially separating the coelomic cavity into thoracic and abdominal portions. It gives rise to the central tendon of the diaphragm. [TFD][VHOG] + 2012-09-17 + VHOG:0000019 + VHOG + + + + + + + In hagfishes a transverse septum extends upward from the ventral body wall posterior to the heart, partly separating an anterior pericardial cavity from a larger peritoneal cavity. (...) These basic relationships have not been modified by urodeles. The small pericardial cavity remains far forward where it is separated by a transverse septum from the principal coelom, which may now be called a pleuroperitoneal cavity because slender lungs are present. (...) The heart (of other tetrapods) is separated from the lungs (and liver if present) by more or less horizontal partitions that have their origin in the embryo as folds on the serous membrane of the right and left lateral body walls. These grow out to join in the midline of the body. They are called lateral mesocardia (birds) or pleuropericardial membranes. Posteriorly they join the transverse septum to form the adult pericardial membrane, or pericardium. (...) In their partitioning of their coelom, embryonic mammals resemble first early fishes (incomplete partition, posterior to heart, consisting of the transverse septum) and then reptiles (pericardium derived from transverse septum and pleuropericardial membranes) Mammals then separate paired pleural cavities from the peritoneal cavity by a diaphragm. The ventral portion of this organ comes from the transverse septum. The dorsal portion is derived from the dorsal mesentery and from still another pair of outgrowths from the lateral body wall, the pleuroperitoneal membranes.[well established][VHOG] + 2012-09-17 + VHOG:0000019 + VHOG + + ISBN:978-0471090588 Hildebrand M, Analysis of vertebrate structure (1983) p.205-206 + + + + + in EHDAA2 this is divided into mesenchymal portion and hepatic diverticulum + EHDAA2 + + + + + UMLS:C0231004 + ncithesaurus:Septum_Transversum + + + + + transverse septum + + + + + + + + + + + + + + + + + + + + + + + + + + + + Organ that is part of the hematopoietic system. + consider splitting out lymph organ, compare with lymph node + the organs in which the formed elements of the blood and lymph are produced[http://encyclopedia2.thefreedictionary.com/Hematopoietic+Organs]. + the FMA class 'lymphoid organ' is a general anatomical term + + BTO:0004605 + EMAPA:37665 + FMA:7143 + MA:0000747 + haematological system organ + haemopoietic system organ + hematopoeitic organ + hematopoietic system organ + organ of haematological system + organ of haemopoietic system + organ of hematopoietic system + organ of organa haemopoietica + organa haemopoietica organ + hematopoeitic or lymphoid organ + lymph organ + lymphoid organ + uberon + UBERON:0004177 + + + hemopoietic organ + + + + + Organ that is part of the hematopoietic system. + GOC:Obol + + + + + the organs in which the formed elements of the blood and lymph are produced[http://encyclopedia2.thefreedictionary.com/Hematopoietic+Organs]. + + + + + + the FMA class 'lymphoid organ' is a general anatomical term + FMA + + + + + EMAPA:37665 + MA:th + + + + + haematological system organ + OBOL:automatic + + + + + haemopoietic system organ + OBOL:automatic + + + + + hematopoietic system organ + OBOL:automatic + + + + + organ of haematological system + OBOL:automatic + + + + + organ of haemopoietic system + OBOL:automatic + + + + + organ of hematopoietic system + OBOL:automatic + + + + + organ of organa haemopoietica + OBOL:automatic + + + + + organa haemopoietica organ + OBOL:automatic + + + + + lymph organ + MA:0000747 + + + + + lymphoid organ + BTO:0004605 + FMA:7143 + + + + + + + + + + + + + + + + + + + + + + + + + A portions of the gut that is derived from endoderm. + EMAPA:32930 + endodermal gut + gut endoderm + uberon + UBERON:0004185 + endodermal part of digestive tract + + + + + A portions of the gut that is derived from endoderm. + GO:0061031 + + + + + gut endoderm + EMAPA:32930 + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of smooth muscle tissue that is part of a respiratory system [Automatically generated definition]. + BTO:0001660 + EMAPA:35734 + MA:0001830 + respiratory smooth muscle + smooth muscle of respiratory system + uberon + airway smooth muscle + airway smooth muscle cell + UBERON:0004225 + respiratory system smooth muscle + + + + + A portion of smooth muscle tissue that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + + + + + respiratory smooth muscle + BTO:0001660 + + + + + smooth muscle of respiratory system + OBOL:automatic + + + + + airway smooth muscle + BTO:0001660 + + + + + airway smooth muscle cell + BTO:0001660 + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of smooth muscle tissue that is part of a iris [Automatically generated definition]. + see notes for muscle of iris. + BTO:0000655 + EMAPA:35448 + FMA:312338 + MA:0001270 + involuntary muscle of iris + iridial smooth muscle + iris involuntary muscle + iris non-striated muscle + iris smooth muscle tissue + non-striated muscle of iris + smooth muscle of iris + smooth muscle tissue of iris + uberon + UBERON:0004234 + iris smooth muscle + + + + + + MA + + + + + A portion of smooth muscle tissue that is part of a iris [Automatically generated definition]. + OBOL:automatic + + + + + involuntary muscle of iris + OBOL:automatic + + + + + iridial smooth muscle + + + + + + iris involuntary muscle + OBOL:automatic + + + + + iris non-striated muscle + OBOL:automatic + + + + + iris smooth muscle tissue + OBOL:automatic + + + + + non-striated muscle of iris + OBOL:automatic + + + + + smooth muscle of iris + OBOL:automatic + + + + + smooth muscle tissue of iris + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of smooth muscle tissue that is part of an arteriole [Automatically generated definition]. + EMAPA:36287 + FMA:312251 + MA:0000706 + uberon + UBERON:0004236 + arteriole smooth muscle + + + + + A portion of smooth muscle tissue that is part of an arteriole [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + smooth muscle found within, and composing the majority of the wall of blood vessels. + Vascular smooth muscle contracts or relaxes to both change the volume of blood vessels and the local blood pressure, a mechanism that is responsible for the redistribution of the blood within the body to areas where it is needed (i.e. areas with temporarily enhanced oxygen consumption). Thus the main function of vascular smooth muscle tonus is to regulate the caliber of the blood vessels in the body. Excessive vasoconstriction leads to hypertension, while excessive vasodilation as in shock leads to hypotension. + UBERON:0010508 + + + BTO:0001431 + CALOHA:TS-1107 + EMAPA:35177 + MA:0000710 + MESH:D009131 + NCIT:C33853 + TAO:0005321 + UMLS:C1519956 + ZFA:0005321 + blood vessel involuntary muscle + blood vessel non-striated muscle + blood vessel smooth muscle tissue + involuntary muscle of blood vessel + non-striated muscle of blood vessel + smooth muscle of blood vessel + smooth muscle tissue of blood vessel + vascular smooth muscle + vascular smooth muscle tissue + uberon + UBERON:0004237 + + blood vessel smooth muscle + + + + + smooth muscle found within, and composing the majority of the wall of blood vessels. + + + + + + UMLS:C1519956 + ncithesaurus:Vascular_Smooth_Muscle_Tissue + + + + + blood vessel involuntary muscle + OBOL:automatic + + + + + blood vessel non-striated muscle + OBOL:automatic + + + + + blood vessel smooth muscle tissue + OBOL:automatic + + + + + involuntary muscle of blood vessel + OBOL:automatic + + + + + non-striated muscle of blood vessel + OBOL:automatic + + + + + smooth muscle of blood vessel + OBOL:automatic + + + + + smooth muscle tissue of blood vessel + OBOL:automatic + + + + + vascular smooth muscle + ZFA:0005321 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any muscle organ that is part of a skin of body [Automatically generated definition]. + review as part of general integumentary system review - part of skin, or more generally, integumental system + in MA, the only skin muscle is arrector pili. The only integumental muscle is panniculus carnosus. In EMAPA, the arrector pili only + UBERON:0015797 + EMAPA:18187 + EMAPA:35776 + MA:0002710 + MA:0003139 + integumental system muscle + muscle of integumental system + muscle organ of skin + skin muscle organ + uberon + UBERON:0004253 + skin muscle + + + + + Any muscle organ that is part of a skin of body [Automatically generated definition]. + OBOL:automatic + + + + + in MA, the only skin muscle is arrector pili. The only integumental muscle is panniculus carnosus. In EMAPA, the arrector pili only + MA + + + + + integumental system muscle + MA:0003139 + + + + + muscle of integumental system + EMAPA:18187 + + + + + muscle organ of skin + OBOL:automatic + + + + + skin muscle organ + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A blood vessel that is part of a back [Automatically generated definition]. + EMAPA:37243 + MA:0000493 + blood vessel of back + uberon + UBERON:0004258 + back blood vessel + + + + + A blood vessel that is part of a back [Automatically generated definition]. + OBOL:automatic + + + + + EMAPA:37243 + MA:th + + + + + blood vessel of back + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of connective tissue that is part of a back [Automatically generated definition]. + EMAPA:37256 + MA:0000495 + uberon + mesenchyne of back + UBERON:0004267 + back connective tissue + + + + + A portion of connective tissue that is part of a back [Automatically generated definition]. + OBOL:automatic + + + + + EMAPA:37256 + MA:th + + + + + mesenchyne of back + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A muscle that is part of the eye region. + AAO:0000156 + EMAPA:35335 + MA:0000271 + OpenCyc:Mx8Ngx4rwKSh9pwpEbGdrcN5Y29ycB4rvViTvpwpEbGdrcN5Y29ycB4rvYA8cJwpEbGdrcN5Y29ycA + uberon + UBERON:0004277 + + eye muscle + + + + + + + + + + + MA + + + + + A muscle that is part of the eye region. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + Anatomical cluster that consists of all the skeletal elements (eg., bone, cartilage, and teeth) of the body. + Anatomical cluster that consists of all the skeletal elements (eg., bone, cartilage, and teeth) of the body.[VSAO] + skeletal + + + AEO:0000168 + EHDAA2:0001843 + EHDAA:5047 + EMAPA:17213 + FMA:23875 + GAID:177 + MA:0003006 + MAT:0000032 + MESH:D012863 + MIAA:0000032 + OpenCyc:Mx4rvVi1rpwpEbGdrcN5Y29ycA + VSAO:0000026 + XAO:0004053 + galen:Skeleton + set of all bones + set of bones of body + uberon + UBERON:0004288 + + + + skeleton + https://github.com/obophenotype/uberon/wiki/The-skeletal-system + + + + + Anatomical cluster that consists of all the skeletal elements (eg., bone, cartilage, and teeth) of the body. + VSAO:0000026 + + + + + Anatomical cluster that consists of all the skeletal elements (eg., bone, cartilage, and teeth) of the body.[VSAO] + 2012-08-14 + VSAO:0000026 + VSAO + GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 + + + + + + + + + + + + + + + + + The bilaminar epithelium formed from the myotome and dermatome. + Epithelial sheet on the external surface of the somite that gives rise to trunk, muscle and dermis. Within the dermomyotome there is also a medio-lateral difference. The central region makes dermis, the mesenchymal connective tissue of the back skin. The medial region (closest to neural tube) makes epaxial muscle, and the lateral region (furthest from neural tube) makes hypaxial muscle[http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=eurekah&part=A66768]. + Epithelial sheet on the external surface of the somite that gives rise to trunk, muscle and dermis.[TAO] + Portion of somites that gives rise to dermis and muscles.[AAO] + all but the sclerotome of a mesodermal somite; the primordium of skeletal muscle and, perhaps, of the dermis. + Thus, representatives of the agnathan vertebrates, chondrichthyans, and sarcopterygians all have a layer of undifferentiated cells external to the embryonic myotome. In the amniotes, this external cell layer is the dermomyotome. The simplest interpretation of the similar position, morphology, and lack of myosin labeling is that a dermomyotome epithelium is a shared, ancestral vertebrate characteristic.[well established][VHOG] + + AAO:0010572 + AEO:0000214 + EHDAA2:0003259 + EMAPA:31109 + FMA:295654 + NCIT:C34140 + TAO:0001513 + UMLS:C1511786 + VHOG:0000676 + ZFA:0001513 + uberon + dermamyotome + dermomyotomes + UBERON:0004290 + dermomyotome + + + + + + AEO + + + + + + AEO + + + + + + + + + + + EHDAA2 + ZFA + + + + + The bilaminar epithelium formed from the myotome and dermatome. + AEO:0000214 + + + + + Epithelial sheet on the external surface of the somite that gives rise to trunk, muscle and dermis. Within the dermomyotome there is also a medio-lateral difference. The central region makes dermis, the mesenchymal connective tissue of the back skin. The medial region (closest to neural tube) makes epaxial muscle, and the lateral region (furthest from neural tube) makes hypaxial muscle[http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=eurekah&part=A66768]. + + + + + + Epithelial sheet on the external surface of the somite that gives rise to trunk, muscle and dermis.[TAO] + 2012-08-14 + TAO:0001513 + TAO + ZFIN:curator + + + + + Portion of somites that gives rise to dermis and muscles.[AAO] + 2012-06-20 + AAO:0010572 + AAO + AAO:EJS + + + + + all but the sclerotome of a mesodermal somite; the primordium of skeletal muscle and, perhaps, of the dermis. + + + + + + Thus, representatives of the agnathan vertebrates, chondrichthyans, and sarcopterygians all have a layer of undifferentiated cells external to the embryonic myotome. In the amniotes, this external cell layer is the dermomyotome. The simplest interpretation of the similar position, morphology, and lack of myosin labeling is that a dermomyotome epithelium is a shared, ancestral vertebrate characteristic.[well established][VHOG] + 2012-09-17 + VHOG:0000676 + VHOG + + DOI:10.1111/j.1525-142X.2006.05079.x Devoto SH, Stoiber W, Hammond CL, Steinbacher P, Haslett JR, Barresi MJF, Patterson SE, Adiarte EG and Hughes SM, Generality of vertebrate developmental patterns: evidence for a dermomyotome in fish. Evolution and Development (2006) + + + + + UMLS:C1511786 + ncithesaurus:Dermomyotome + + + + + dermamyotome + VHOG:0000676 + + + + + dermomyotomes + VHOG:0000676 + + + + + + + + + + + + + + + + A cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube. + The migrating myocardial precursors of the heart rudiment form a cone like structure between 19.5hpf and 22hpf, and eventually telescope out into the primitive heart tube at 24hpf. Stainier 2001.[TAO] + TAO:0000115 + ZFA:0000115 + heart cone + rudimentary heart + uberon + UBERON:0004291 + heart rudiment + + + + + A cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube. + GO:0003313 + + + + + The migrating myocardial precursors of the heart rudiment form a cone like structure between 19.5hpf and 22hpf, and eventually telescope out into the primitive heart tube at 24hpf. Stainier 2001.[TAO] + 2012-08-14 + TAO:0000115 + TAO + ZFIN:curator + + + + + heart cone + GO:0003313 + + + + + rudimentary heart + ZFA:0000115 + + + + + + + + + + + + + + + + + + + + + + + + + + + + Dense connective tissue that separates the atria from the ventricles and provides physical support for the heart. + It is not a true skeleton, but it does provide structure and support for the heart, as well as isolating the atria from the ventricles. This allows the AV node and AV bundle to delay the wave of depolarisation such that the atria can contract and assist in ventricular filling before the ventricles themselves depolarise and contract (the AV bundle is the only part of the conduction system that passes from the atria to the ventricles in a normal heart). It also allows the valves (bicuspid, tricuspid, semilunar) to keep open by giving them structural support[WP] + + EMAPA:36645 + FMA:9496 + cardiac fibrous skeleton + fibrous skeleton of heart + heart fibrous skeleton + skeleton of heart + uberon + anulus fibrosus dexter cordis + anulus fibrosus sinister cordis + trigona fibrosa + trigonum fibrosum dextrum cordis + trigonum fibrosum sinistrum cordis + UBERON:0004292 + cardiac skeleton + http://upload.wikimedia.org/wikipedia/commons/5/50/Gray495.png + + + + + Dense connective tissue that separates the atria from the ventricles and provides physical support for the heart. + + GO:0003204 + + + + + cardiac fibrous skeleton + EMAPA:36645 + + + + + heart fibrous skeleton + GO:0003204 + + + + + skeleton of heart + FMA:9496 + + + + + anulus fibrosus dexter cordis + + + + + + + anulus fibrosus sinister cordis + + + + + + + trigona fibrosa + + + + + + + trigonum fibrosum dextrum cordis + + + + + + + trigonum fibrosum sinistrum cordis + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A blood vessel smooth muscle that is part of a respiratory system [Automatically generated definition]. + EMAPA:37573 + MA:0001806 + smooth muscle tissue of blood vessel of respiratory system + uberon + UBERON:0004297 + respiratory system blood vessel smooth muscle + + + + + A blood vessel smooth muscle that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + + + + + EMAPA:37573 + MA:th + + + + + smooth muscle tissue of blood vessel of respiratory system + OBOL:automatic + + + + + + + + + + + + + + + The embryonic structure that gives rise to the corneal ectoderm + EHDAA:938 + EMAPA:16322 + RETIRED_EHDAA2:0001308 + VHOG:0001296 + uberon + UBERON:0004348 + + optic eminence + + + + + The embryonic structure that gives rise to the corneal ectoderm + MP:0006305 + + + + + + + + + The first of the series of pharyngeal arches that develop into jaw bones or their homologs, and their associated nerves and arteries + The first of the series of bony or cartilaginous arches that develop in the walls of the mouth cavity and pharynx of the embryo.[AAO] + the first arch which contributes to development of mastication muscles, maxilla, mandible, incus, malleus, Meckel's cartilage, trigeminal nerve, and maxillary artery + A conserved feature of all vertebrate embryos is the presence of a series of bulges on the lateral surface of the head, the pharyngeal arches; it is within these structures that the nerves, muscles and skeletal components of the pharyngeal apparatus are laid down. The pharyngeal arches are separated by endodermal outpocketings, the pharyngeal pouches.[well established][VHOG] + 1 + + + + AAO:0010364 + CALOHA:TS-2089 + EHDAA2:0000006 + EHDAA:573 + EMAPA:16118 + FMA:293019 + MFMO:0000095 + NCIT:C34175 + TAO:0001595 + UMLS:C1517197 + VHOG:0000296 + XAO:0000097 + ZFA:0001612 + 1st pharyngeal arch + branchial arch 1 + first branchial arch + first pharyngeal arch + first visceral arch + mandibular arch + visceral arch 1 + uberon + 1st arch + 1st visceral arch + arcus pharyngeus primus + UBERON:0004362 + + + + pharyngeal arch 1 + http://upload.wikimedia.org/wikipedia/commons/2/2d/Gray48.png + + + + + The first of the series of pharyngeal arches that develop into jaw bones or their homologs, and their associated nerves and arteries + + + + + + The first of the series of bony or cartilaginous arches that develop in the walls of the mouth cavity and pharynx of the embryo.[AAO] + 2012-06-20 + AAO:0010364 + AAO + XAO:EJS + + + + + the first arch which contributes to development of mastication muscles, maxilla, mandible, incus, malleus, Meckel's cartilage, trigeminal nerve, and maxillary artery + MP:0006337,MGI:smb + + + + + A conserved feature of all vertebrate embryos is the presence of a series of bulges on the lateral surface of the head, the pharyngeal arches; it is within these structures that the nerves, muscles and skeletal components of the pharyngeal apparatus are laid down. The pharyngeal arches are separated by endodermal outpocketings, the pharyngeal pouches.[well established][VHOG] + 2012-09-17 + VHOG:0000296 + VHOG + + DOI:10.1111/j.1469-7580.2005.00472.x Graham A, Okabe M and Quinlan R, The role of the endoderm in the development and evolution of the pharyngeal arches. J Anat (2005) + + + + + UMLS:C1517197 + ncithesaurus:First_Pharyngeal_Arch + + + + + branchial arch 1 + + + + + + first branchial arch + + + + + + first visceral arch + + + + + + visceral arch 1 + + + + + + 1st arch + EHDAA2:0000006 + + + + + 1st visceral arch + VHOG:0000296 + + + + + arcus pharyngeus primus + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A transparent homogeneous acellular layer, 6 to 9 um thick, lying between the basal lamina of the outer layer of stratified epithelium and the substantia propria of the cornea; it is considered to be a basement membrane. + Acellular anatomical structure that is the zone of collagen fibers adjacent the basement membrane of the corneal epithelium.[TAO] + Compared to terrestial animals, the cornea of zebrafish is relatively flat. It consists of nonpigmented, stratified squamous nonkeratinizing epithelial cells, attached to a thick basement membrane that is considered to be analogous to the Bowman's membrane in mammals + + + + FMA:58273 + MA:0001240 + NCIT:C32226 + TAO:0002155 + UMLS:C0229127 + ZFA:0001684 + Bowman's anterior elastic lamina + Bowman's layer + Bowman's membrane + anterior elastic lamina + anterior limiting lamina + anterior limiting lamina of cornea + lamina limitans anterior (cornea) + lamina limitans anterior corneae + uberon + Reichert's membrane + anterior limiting membrane + UBERON:0004370 + + + anterior limiting lamina of cornea + + + + + A transparent homogeneous acellular layer, 6 to 9 um thick, lying between the basal lamina of the outer layer of stratified epithelium and the substantia propria of the cornea; it is considered to be a basement membrane. + ncithesaurus:Bowman_s_Membrane + + + + + Acellular anatomical structure that is the zone of collagen fibers adjacent the basement membrane of the corneal epithelium.[TAO] + 2012-08-14 + TAO:0002155 + TAO + ZFIN:ZDB-PUB-061010-3 + + + + + UMLS:C0229127 + ncithesaurus:Bowman_s_Membrane + + + + + Bowman's anterior elastic lamina + FMA:58273 + + + + + Bowman's layer + FMA:58273 + + + + + Bowman's membrane + FMA:58273 + + + + + anterior elastic lamina + ZFA:0001684 + + + + + anterior limiting lamina + MA:0001240 + + + + + anterior limiting lamina of cornea + FMA:58273 + + + + + lamina limitans anterior (cornea) + FMA:58273 + + + + + lamina limitans anterior corneae + FMA:58273 + FMA:TA + + + + + + Reichert's membrane + + + + + + + anterior limiting membrane + ZFA:0001684 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An embryo at the neurula stage. + UBERON:0007013 + + BILA:0000061 + BTO:0001766 + NCIT:C34229 + UMLS:C1518306 + neurula + uberon + UBERON:0004455 + neurula embryo + + + + + An embryo at the neurula stage. + + + + + + UMLS:C1518306 + ncithesaurus:Neurula + + + + + neurula + BTO:0001766 + + + + + + + + + + + + + + + + + + + + + + + + + + + Sum of all sensory systems in an organism. + note the distinct between entire sensory system and individual system. this reconciles is_a and part_of distinctions between ssAOs + FMA:78499 + sense organ system + uberon + UBERON:0004456 + + entire sense organ system + + + + + Sum of all sensory systems in an organism. + + + + + + sense organ system + FMA:78499 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any collection of skeletal muscles that is part of a head [Automatically generated definition]. + EMAPA:18171 + FMA:71287 + head musculature + muscle group of head + muscles of head + musculi capitis + set of muscles of head + uberon + UBERON:0004461 + + This class is restricted to skeletal muscles that attach to the cranial skeleton. This seems to be consistent with FMA and EMAPA usage. Note that by definition this excludes invertebrate head musculature. It corresponds to the individual muscle organ term UBERON:0002376 + skeletal musculature of head + https://github.com/obophenotype/mouse-anatomy-ontology/issues/4 + https://github.com/obophenotype/uberon/issues/1405 + + + + + Any collection of skeletal muscles that is part of a head [Automatically generated definition]. + OBOL:automatic + + + + + head musculature + FMA:71287 + + + + + muscle group of head + FMA:71287 + + + + + muscles of head + FMA:71287 + + + + + musculi capitis + FMA:71287 + FMA:TA + + + + + + set of muscles of head + FMA:71287 + + + + + + + + + + + + + + + + + + + + + + + + + + Any collection of muscles that is part of a thorax [Automatically generated definition]. + BTO and FMA do not mean precisely the same thing here. BTO thorax muscle is a pectoral muscle or diaphragm + BTO:0000508 + EMAPA:37260 + FMA:71293 + muscle group of thorax + muscles of thorax + musculi thoracis + set of muscles of thorax + thoracic musculature + uberon + UBERON:0004464 + + musculature of thorax + + + + + Any collection of muscles that is part of a thorax [Automatically generated definition]. + OBOL:automatic + + + + + BTO and FMA do not mean precisely the same thing here. BTO thorax muscle is a pectoral muscle or diaphragm + BTO + + + + + EMAPA:37260 + MA:th + + + + + muscle group of thorax + FMA:71293 + + + + + muscles of thorax + FMA:71293 + + + + + musculi thoracis + FMA:71293 + FMA:TA + + + + + + set of muscles of thorax + FMA:71293 + + + + + thoracic musculature + FMA:71293 + + + + + + + + + + + + + + + + + + + + + + + + + + Any collection of muscles that is part of a neck [Automatically generated definition]. + AAO:0000091 + EMAPA:36050 + FMA:71290 + MESH:D009334 + cervical muscles + muscle group of neck + muscles of neck + musculi cervicis + musculi colli + neck musculature + set of muscles of neck + uberon + UBERON:0004465 + + musculature of neck + + + + + Any collection of muscles that is part of a neck [Automatically generated definition]. + OBOL:automatic + + + + + cervical muscles + AAO:0000091 + + + + + muscle group of neck + FMA:71290 + + + + + muscles of neck + FMA:71290 + + + + + musculi cervicis + FMA:71290 + FMA:TA + + + + + + musculi colli + FMA:71290 + FMA:TA + + + + + + neck musculature + FMA:71290 + + + + + set of muscles of neck + FMA:71290 + + + + + + + + + + + + + + + + + + + + + + + + + + Any collection of muscles that is part of a back [Automatically generated definition]. + FMA:71291 + muscle group of back + muscles of back + musculi dorsi + set of muscles of back + uberon + UBERON:0004469 + musculature of back + + + + + Any collection of muscles that is part of a back [Automatically generated definition]. + OBOL:automatic + + + + + muscle group of back + FMA:71291 + + + + + muscles of back + FMA:71291 + + + + + musculi dorsi + FMA:71291 + FMA:TA + + + + + + set of muscles of back + FMA:71291 + + + + + + + + + + + + + + + + + + + + + + + + + + Any collection of muscles that is part of a face. + originally created to reflect the distinction drawn in FMA between a facial muscle and the entire musculature of the face. However, naming both does not serve any particular purpose + FMA:71288 + entire facial musculature + facial muscles + muscle group of face + musculi faciei + uberon + set of facial muscles + set of muscles of face + UBERON:0004473 + + musculature of face + + + + + Any collection of muscles that is part of a face. + OBOL:automatic + + + + + entire facial musculature + + + + + + facial muscles + FMA:71288 + + + + + muscle group of face + FMA:71288 + + + + + musculi faciei + FMA:71288 + FMA:TA + + + + + + set of facial muscles + FMA:71288 + + + + + set of muscles of face + FMA:71288 + + + + + + + + + + + + + + + + + + + + + + + + + + Any collection of muscles that is part of a trunk [Automatically generated definition]. + currently defined by location rather than attachment + AAO:0011572 + EFO:0003531 + FMA:50187 + muscle group of trunk + set of muscles of trunk + uberon + muscular system of trunk + UBERON:0004479 + + + musculature of trunk + + + + + Any collection of muscles that is part of a trunk [Automatically generated definition]. + OBOL:automatic + + + + + muscle group of trunk + FMA:50187 + + + + + set of muscles of trunk + FMA:50187 + + + + + muscular system of trunk + FMA:50187 + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of cardiac muscle tissue that is part of an atrium [Automatically generated definition]. + in GO, this is equivalent to the atrial myocardium, but FMA distinguishes these two. Consider merging. + FMA:7283 + atrial cardiac muscle tissue + atrial heart muscle + cardiac atrium muscle + uberon + atrial myocardium + UBERON:0004490 + cardiac muscle tissue of atrium + + + + + A portion of cardiac muscle tissue that is part of an atrium [Automatically generated definition]. + OBOL:automatic + + + + + in GO, this is equivalent to the atrial myocardium, but FMA distinguishes these two. Consider merging. + GO + + + + + atrial cardiac muscle tissue + GO:0055009 + + + + + atrial heart muscle + GO:0055009 + + + + + cardiac atrium muscle + GO:0055009 + + + + + atrial myocardium + GO:0055009 + GOC:mtg_heart + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of cardiac muscle tissue that is part of a cardiac septum [Automatically generated definition]. + FMA:226279 + cardiac septum cardiac muscle tissue + cardiac septum heart muscle + cardiac septum muscle + cardiac septum myocardium + uberon + UBERON:0004492 + cardiac muscle tissue of cardiac septum + + + + + A portion of cardiac muscle tissue that is part of a cardiac septum [Automatically generated definition]. + OBOL:automatic + + + + + cardiac septum cardiac muscle tissue + + + + + + cardiac septum heart muscle + + + + + + cardiac septum muscle + + + + + + cardiac septum myocardium + + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of cardiac muscle tissue that is part of a myocardium [Automatically generated definition]. + Note placement of MA class based on parthood relationship + EMAPA:32688 + FMA:261726 + MA:0002441 + uberon + UBERON:0004493 + + cardiac muscle tissue of myocardium + + + + + + + + + + + MA + + + + + A portion of cardiac muscle tissue that is part of a myocardium [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + A vasculature that is part of a muscle organ [Automatically generated definition]. + FMA:87123 + muscular organ vasculature + uberon + UBERON:0004521 + vasculature of muscle organ + + + + + A vasculature that is part of a muscle organ [Automatically generated definition]. + OBOL:automatic + + + + + muscular organ vasculature + FMA:87123 + + + + + + + + + + + + + + + + + + + + + + + + + + A vasculature that is part of a musculoskeletal system [Automatically generated definition]. + FMA:239607 + uberon + UBERON:0004522 + vasculature of musculoskeletal system + + + + + A vasculature that is part of a musculoskeletal system [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Anatomical system that has as its parts the heart and blood vessels. + we treat cardiovascular as part of circulatory system, with the latter including other kinds of circulation, including lymph. + The vessels of the cardiovascular system are as varied as the diverse organs they supply. However, these variations are based on modifications of a fundamental plan of organization common to vertebrates.[well established][VHOG] + + + AAO:0011001 + BILA:0000016 + BTO:0000088 + CALOHA:TS-1297 + EFO:0000791 + EHDAA2:0000216 + EHDAA:394 + EMAPA:16104 + EMAPA:16370 + EV:0100017 + FMA:7161 + GAID:467 + MA:0000010 + MAT:0000016 + MESH:D002319 + MIAA:0000016 + NCIT:C12686 + OpenCyc:Mx4rvVjzG5wpEbGdrcN5Y29ycA + TAO:0000010 + UMLS:C0007226 + VHOG:0000302 + WikipediaCategory:Cardiovascular_system + XAO:0000100 + XAO:0001010 + ZFA:0000010 + uberon + CV system + Herz und Gefaesssystem + UBERON:0004535 + + + + + cardiovascular system + + + + + Anatomical system that has as its parts the heart and blood vessels. + BTO:0000088 + + + + + The vessels of the cardiovascular system are as varied as the diverse organs they supply. However, these variations are based on modifications of a fundamental plan of organization common to vertebrates.[well established][VHOG] + 2012-09-17 + VHOG:0000302 + VHOG + + ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.451 + + + + + UMLS:C0007226 + ncithesaurus:Cardiovascular_System + + + + + CV system + BTO:0000088 + + + + + Herz und Gefaesssystem + BTO:0000088 + + + + + + + + + + + + + + + + + + + + + + + + + + + A vascular network consisting of blood vessels. + TAO:0001079 + ZFA:0001079 + blood vascular network + set of blood vessels + uberon + blood system + blood vessel system + blood vessels + UBERON:0004537 + blood vasculature + + + + + A vascular network consisting of blood vessels. + + + + + + blood vessels + TAO:0001079 + + + + + + + + + + + + + + + + The part of the cardiovascular system consisting of all arteries. + The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG] + + BTO:0004690 + EHDAA2:0000143 + EHDAA:396 + EMAPA:16201 + EMAPA:16371 + MA:0002719 + VHOG:0000273 + uberon + UBERON:0004572 + + arterial system + + + + + + MA + + + + + The part of the cardiovascular system consisting of all arteries. + + + + + + The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG] + 2012-09-17 + VHOG:0000273 + VHOG + + DOI:10.1196/annals.1341.002 Bishopric NH, Evolution of the heart from bacteria to man. Annals of the New York Academy of Sciences (2005) + + + + + + + + + + + + + + + The part of the venous system that drains the general body tissues[Kardong] + In human anatomy, the systemic venous system refers to veins that drain into the right atrium without passing through two vascular beds (i.e. they originate from a set of capillaries and do not pass through a second set of capillaries before reaching the right side of the heart). The term systemic venous system is often used to differentiate veins from veins that drain the pulmonary system (the pulmonary venous system) and veins that drain the digestive tract (the portal venous system). Large veins that are considered part of the systemic venous system are the: Superior vena cava; Inferior vena cava[WP] + Subdivision of cardiovascular system which has as its parts the right side of heart, the superior vena cava and the inferior vena cava[FMA] + The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG] + + FMA:45626 + systemic venous circulatory system + uberon + UBERON:0004581 + systemic venous system + + + + + The part of the venous system that drains the general body tissues[Kardong] + + ISBN:0073040584 + + + + + In human anatomy, the systemic venous system refers to veins that drain into the right atrium without passing through two vascular beds (i.e. they originate from a set of capillaries and do not pass through a second set of capillaries before reaching the right side of the heart). The term systemic venous system is often used to differentiate veins from veins that drain the pulmonary system (the pulmonary venous system) and veins that drain the digestive tract (the portal venous system). Large veins that are considered part of the systemic venous system are the: Superior vena cava; Inferior vena cava[WP] + + + + + + Subdivision of cardiovascular system which has as its parts the right side of heart, the superior vena cava and the inferior vena cava[FMA] + FMA + FMA:45626 + + + + + The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG] + 2012-09-17 + VHOG:0000277 + VHOG + + DOI:10.1196/annals.1341.002 Bishopric NH, Evolution of the heart from bacteria to man. Annals of the New York Academy of Sciences (2005) + + + + + systemic venous circulatory system + FMA:45626 + + + + + + + + + + + + + + + + The part of the cardiovascular system consisting of all venous vessels. In vertebrates with a double circulation, this can be divided into systemic and pulmonary portions. + The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG] + + + BTO:0004692 + EHDAA2:0002171 + EHDAA:486 + EMAPA:16240 + MA:0002720 + NCIT:C33858 + UMLS:C1267406 + VHOG:0000277 + vein system + uberon + UBERON:0004582 + venous system + + + + + + MA + + + + + The part of the cardiovascular system consisting of all venous vessels. In vertebrates with a double circulation, this can be divided into systemic and pulmonary portions. + + + + + + The appearance of Chordata and subsequently the vertebrates is accompanied by a rapid structural diversification of this primitive linear heart: looping, unidirectional circulation, an enclosed vasculature, and the conduction system.[well established][VHOG] + 2012-09-17 + VHOG:0000277 + VHOG + + DOI:10.1196/annals.1341.002 Bishopric NH, Evolution of the heart from bacteria to man. Annals of the New York Academy of Sciences (2005) + + + + + UMLS:C1267406 + ncithesaurus:Venous_System + + + + + + + + + + + + + + + + + + + + + + + + + + An endothelium that lines the blood vasculature. Other endothelia may line lymph vessels, the heart + + BTO:0000766 + CALOHA:TS-2155 + EMAPA:35176 + MA:0000709 + NCIT:C53395 + TAO:0005257 + UMLS:C1706972 + ZFA:0005257 + uberon + UBERON:0004638 + + + blood vessel endothelium + + + + + An endothelium that lines the blood vasculature. Other endothelia may line lymph vessels, the heart + + + + + + UMLS:C1706972 + ncithesaurus:Blood_Vessel_Endothelium + + + + + + + + + The costocervical trunk arises from the upper and back part of the subclavian artery, behind the scalenus anterior on the right side, and medial to that muscle on the left side. Passing backward, it splits into the deep cervical artery and the supreme intercostal artery (or the Highest intercostal artery), which descends behind the pleura in front of the necks of the first and second ribs, and anastomoses with the first aortic intercostal (3rd posterior intercostal artery). As it crosses the neck of the first rib it lies medial to the anterior division of the first thoracic nerve, and lateral to the first thoracic ganglion of the sympathetic trunk. In the first intercostal space, it gives off a branch which is distributed in a manner similar to the distribution of the aortic intercostals. The branch for the second intercostal space usually joins with one from the highest aortic intercostal artery. This branch is not constant, but is more commonly found on the right side; when absent, its place is supplied by an intercostal branch from the aorta. Each intercostal gives off a posterior branch which goes to the posterior vertebral muscles, and sends a small spinal branch through the corresponding intervertebral foramen to the medulla spinalis and its membranes. [WP,unvetted]. + + + EMAPA:37496 + FMA:10636 + MA:0001939 + costocervical trunk + trunk of costocervical artery + uberon + truncus costocervicalis + UBERON:0004688 + costo-cervical trunk + http://upload.wikimedia.org/wikipedia/commons/b/b3/Costocervical_trunk_with_branches.png + + + + + The costocervical trunk arises from the upper and back part of the subclavian artery, behind the scalenus anterior on the right side, and medial to that muscle on the left side. Passing backward, it splits into the deep cervical artery and the supreme intercostal artery (or the Highest intercostal artery), which descends behind the pleura in front of the necks of the first and second ribs, and anastomoses with the first aortic intercostal (3rd posterior intercostal artery). As it crosses the neck of the first rib it lies medial to the anterior division of the first thoracic nerve, and lateral to the first thoracic ganglion of the sympathetic trunk. In the first intercostal space, it gives off a branch which is distributed in a manner similar to the distribution of the aortic intercostals. The branch for the second intercostal space usually joins with one from the highest aortic intercostal artery. This branch is not constant, but is more commonly found on the right side; when absent, its place is supplied by an intercostal branch from the aorta. Each intercostal gives off a posterior branch which goes to the posterior vertebral muscles, and sends a small spinal branch through the corresponding intervertebral foramen to the medulla spinalis and its membranes. [WP,unvetted]. + + + + + + EMAPA:37496 + MA:th + + + + + costocervical trunk + FMA:10636 + + + + + trunk of costocervical artery + FMA:10636 + + + + + truncus costocervicalis + + + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of smooth muscle tissue that is part of an arterial system [Automatically generated definition]. + EMAPA:36503 + MA:0000704 + uberon + UBERON:0004695 + arterial system smooth muscle + + + + + A portion of smooth muscle tissue that is part of an arterial system [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of smooth muscle tissue that is part of a venous system [Automatically generated definition]. + EMAPA:36613 + MA:0000715 + uberon + UBERON:0004696 + venous system smooth muscle + + + + + A portion of smooth muscle tissue that is part of a venous system [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + An endothelium that is part of an arterial system [Automatically generated definition]. + + EMAPA:35145 + MA:0000703 + NCIT:C49329 + UMLS:C1706849 + uberon + UBERON:0004700 + arterial system endothelium + + + + + An endothelium that is part of an arterial system [Automatically generated definition]. + OBOL:automatic + + + + + UMLS:C1706849 + ncithesaurus:Arterial_System_Endothelium + + + + + + + + + + + + + + + + + + + + + + + + + + An endothelium that is part of a venous system [Automatically generated definition]. + + EMAPA:35907 + MA:0000714 + NCIT:C49320 + UMLS:C1710626 + uberon + UBERON:0004701 + venous system endothelium + + + + + An endothelium that is part of a venous system [Automatically generated definition]. + OBOL:automatic + + + + + UMLS:C1710626 + ncithesaurus:Venous_System_Endothelium + + + + + + + + + + + + + + + + + + + + + + + + + + + A blood vessel endothelium that is part of a respiratory system [Automatically generated definition]. + EMAPA:35732 + MA:0001805 + uberon + UBERON:0004702 + respiratory system blood vessel endothelium + + + + + A blood vessel endothelium that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + The jugular veins are veins that bring deoxygenated blood from the head back to the heart via the superior vena cava. + + + + BTO:0001744 + CALOHA:TS-0497 + EMAPA:18638 + GAID:536 + MA:0002154 + MESH:D007601 + NCIT:C12738 + UMLS:C0022427 + uberon + jugular + vena jugularis + UBERON:0004711 + jugular vein + http://upload.wikimedia.org/wikipedia/commons/f/f8/Gray558.png + + + + + The jugular veins are veins that bring deoxygenated blood from the head back to the heart via the superior vena cava. + + + + + + UMLS:C0022427 + ncithesaurus:Jugular_Vein + + + + + vena jugularis + BTO:0001744 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The embryo and its adnexa (appendages or adjunct parts) or associated membranes (i.e. the products of conception) The conceptus includes all structures that develop from the zygote, both embryonic and extraembryonic. It includes the embryo as well as the embryonic part of the placenta and its associated membranes - amnion, chorion (gestational sac), and yolk sac[WP]. + EHDAA2 places this as a subtype of organism. This leads to the inference that a conceptus is an embryo (if an embryo is defined as an organism at embryo stage), which eliminates the embryonic + extra-embryonic = conceptus + + + AEO:0000194 + BTO:0003834 + EHDAA2:0000001 + EHDAA2:0003235 + EMAPA:36040 + NCIT:C34131 + UMLS:C1516779 + embryo plus adnexa + uberon + UBERON:0004716 + conceptus + + + + + The embryo and its adnexa (appendages or adjunct parts) or associated membranes (i.e. the products of conception) The conceptus includes all structures that develop from the zygote, both embryonic and extraembryonic. It includes the embryo as well as the embryonic part of the placenta and its associated membranes - amnion, chorion (gestational sac), and yolk sac[WP]. + + BTO:0003834 + + + + + UMLS:C1516779 + ncithesaurus:Conceptus + + + + + + + + + + + + + + + + + + + + + + + + + + + A transverse unitary subdivision of the neural tube that shares a common dorsoventral structure (floor, basal, alar, and roof plates), but each having differential molecular identities and fates; they comprise the secondary prosencephalon, diencephalon (prosomeres), the midbrain (mesomeres), and the hindbrain (rhombomeres). + We take the definition of neuromere from Puelles et al, although the existence of mesomeres and prosomeres may not be widely accepted + A metameric segment of the central nervous system.[ZFA] + Melissa Haendel + 2009-06-18T09:00:04Z + + NLX:147842 + TAO:0001328 + ZFA:0001328 + neural tube metameric segment + neural tube segment + neuromere + neuromeres + uberon + neural metamere + neural segment + UBERON:0004731 + + neuromere + + + + + A transverse unitary subdivision of the neural tube that shares a common dorsoventral structure (floor, basal, alar, and roof plates), but each having differential molecular identities and fates; they comprise the secondary prosencephalon, diencephalon (prosomeres), the midbrain (mesomeres), and the hindbrain (rhombomeres). + + + + + + + A metameric segment of the central nervous system.[ZFA] + 2012-08-14 + TAO:0001328 + TAO + ZFIN:curator + + + + + neural tube metameric segment + + + + + + neuromeres + TAO:0001328 + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any segmental subdivision of a nervous system. Includes metameric developmental segments, such as vertebrates neuromeres. + revisit this after CARO is revised and/or we have defined metameric segment; note that with the additional of an A/P axis constraint this corresponds to what Richter at al call a neuromere (PMID:21062451) + FBbt:00005140 + uberon + neuromere + UBERON:0004732 + + segmental subdivision of nervous system + + + + + Any segmental subdivision of a nervous system. Includes metameric developmental segments, such as vertebrates neuromeres. + + FBbt:00005140 + + + + + neuromere + FBbt:00005140 + + + + + + + + + + + + + + + + + + + + + + + + + + + + An organ subunit that is part of a hindbrain [Automatically generated definition]. + FMA:61998 + hindbrain segment + segment of hindbrain + uberon + UBERON:0004733 + + segmental subdivision of hindbrain + + + + + An organ subunit that is part of a hindbrain [Automatically generated definition]. + OBOL:automatic + + + + + hindbrain segment + FMA:61998 + + + + + segment of hindbrain + FMA:61998 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Organism at the gastrula stage. + We explicitly merge the NCITA terms here + UBERON:0007012 + + + + + BILA:0000060 + BTO:0001403 + FBbt:00005317 + FMA:293108 + GAID:1302 + MESH:A16.254.412 + MIAA:0000179 + NCIT:C34057 + NCIT:C34058 + UMLS:C0017199 + UMLS:C1284022 + gastrula embryo + uberon + blastocystis trilaminaris + tri-laminar disc + tri-laminar disk + trilaminar blastocyst + trilaminar blastoderm + trilaminar disc + trilaminar disk + trilaminar germ + UBERON:0004734 + + gastrula + + + + + Organism at the gastrula stage. + + + + + + + We explicitly merge the NCITA terms here + NCIT + + + + + UMLS:C0017199 + ncithesaurus:Gastrula + + + + + UMLS:C1284022 + ncithesaurus:Trilaminar_Embryonic_Disc + + + + + gastrula embryo + BILA:0000060 + + + + + blastocystis trilaminaris + + + + + + tri-laminar disc + + + + + + tri-laminar disk + + + + + + trilaminar blastocyst + + + + + + trilaminar blastoderm + + + + + + trilaminar disc + + + + + + trilaminar disk + + + + + + trilaminar germ + + + + + + + + + + + + + + + + Organ consisting of skeletal tissue. Encompasses whole bones, fused bones, cartilaginious elements, teeth, dermal denticles. + Organ entity that is typically involved in mechanical support and may have different skeletal tissue compositions at different stages.[VSAO] + Organ entity that may have different tissue compositions at different stages and is typically involved in mechanical support.[TAO] + AAO:0011129 + TAO:0001890 + VSAO:0000128 + XAO:0004012 + ZFA:0005494 + galen:SkeletalStructure + uberon + UBERON:0004765 + + + skeletal element + + + + + + + + + + + VSAO + + + + + Organ consisting of skeletal tissue. Encompasses whole bones, fused bones, cartilaginious elements, teeth, dermal denticles. + + + + + + Organ entity that is typically involved in mechanical support and may have different skeletal tissue compositions at different stages.[VSAO] + 2012-08-14 + VSAO:0000128 + VSAO + PSPUB:0000170 + + + + + Organ entity that may have different tissue compositions at different stages and is typically involved in mechanical support.[TAO] + 2012-08-14 + TAO:0001890 + TAO + TAO:VSAO_workshop + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Anatomical system that consists of all the joints of the body. + + EMAPA:35150 + FMA:23878 + MA:0003007 + VSAO:0000181 + joint system + set of all joints of body + uberon + set of all joints + set of joints of body + UBERON:0004770 + articular system + + + + + + + + + + + FMA + + + + + Anatomical system that consists of all the joints of the body. + VSAO:0000181 + + + + + joint system + FMA:23878 + + + + + set of all joints of body + FMA:23878 + + + + + set of joints of body + FMA:23878 + + + + + + + + + + + + + + + + + + + + + + + + + + A submucosa that is part of a respiratory system [Automatically generated definition]. + EMAPA:37578 + MA:0001822 + apparatus respiratorius submucosa + submucosa of apparatus respiratorius + submucosa of respiratory system + uberon + UBERON:0004777 + respiratory system submucosa + + + + + A submucosa that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + + + + + EMAPA:37578 + MA:th + + + + + apparatus respiratorius submucosa + OBOL:automatic + + + + + submucosa of apparatus respiratorius + OBOL:automatic + + + + + submucosa of respiratory system + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A lamina propria that is part of a respiratory system [Automatically generated definition]. + EMAPA:37576 + MA:0001821 + apparatus respiratorius lamina propria + apparatus respiratorius lamina propria mucosa + lamina propria mucosa of apparatus respiratorius + lamina propria mucosa of respiratory system + lamina propria of apparatus respiratorius + lamina propria of respiratory system + respiratory system lamina propria mucosa + uberon + UBERON:0004779 + respiratory system lamina propria + + + + + + + + + + + true + + + + + + A lamina propria that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + + + + + EMAPA:37576 + MA:th + + + + + apparatus respiratorius lamina propria + OBOL:automatic + + + + + apparatus respiratorius lamina propria mucosa + OBOL:automatic + + + + + lamina propria mucosa of apparatus respiratorius + OBOL:automatic + + + + + lamina propria mucosa of respiratory system + OBOL:automatic + + + + + lamina propria of apparatus respiratorius + OBOL:automatic + + + + + lamina propria of respiratory system + OBOL:automatic + + + + + respiratory system lamina propria mucosa + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical wall that is part of a cardiac ventricle [Automatically generated definition]. + FMA:13884 + MA:0002791 + NCIT:C119295 + anatomical wall of cardiac ventricle + anatomical wall of heart ventricle + anatomical wall of lower chamber of heart + anatomical wall of ventricle of heart + cardiac ventricle anatomical wall + cardiac ventricle wall + heart ventricle anatomical wall + lower chamber of heart anatomical wall + lower chamber of heart wall + ventricle of heart anatomical wall + ventricle of heart wall + ventricular wall + wall of cardiac ventricle + wall of heart ventricle + wall of lower chamber of heart + wall of ventricle of heart + uberon + wall of ventricle + UBERON:0004784 + + heart ventricle wall + + + + + An anatomical wall that is part of a cardiac ventricle [Automatically generated definition]. + OBOL:automatic + + + + + anatomical wall of cardiac ventricle + OBOL:automatic + + + + + anatomical wall of heart ventricle + OBOL:automatic + + + + + anatomical wall of lower chamber of heart + OBOL:automatic + + + + + anatomical wall of ventricle of heart + OBOL:automatic + + + + + cardiac ventricle anatomical wall + OBOL:automatic + + + + + cardiac ventricle wall + OBOL:automatic + + + + + heart ventricle anatomical wall + OBOL:automatic + + + + + lower chamber of heart anatomical wall + OBOL:automatic + + + + + lower chamber of heart wall + OBOL:automatic + + + + + ventricle of heart anatomical wall + OBOL:automatic + + + + + ventricle of heart wall + OBOL:automatic + + + + + ventricular wall + FMA:13884 + + + + + wall of cardiac ventricle + OBOL:automatic + + + + + wall of heart ventricle + OBOL:automatic + + + + + wall of lower chamber of heart + OBOL:automatic + + + + + wall of ventricle of heart + OBOL:automatic + + + + + wall of ventricle + MA:0002791 + + + + + + + + + + + + + + + + + + + + + + + + + + the mucous membrane lining the respiratory tract + TODO - split respiratory tract mucosa from respiratory system mucosa + BTO:0000973 + EMAPA:18334 + EMAPA:37577 + FMA:302092 + GAID:304 + MA:0001827 + MESH:D020545 + apparatus respiratorius mucosa + apparatus respiratorius mucosa of organ + apparatus respiratorius mucous membrane + mucosa of apparatus respiratorius + mucosa of organ of apparatus respiratorius + mucosa of organ of respiratory system + mucosa of respiratory system + mucous membrane of apparatus respiratorius + mucous membrane of respiratory system + respiratory system mucosa of organ + respiratory system mucous membrane + uberon + laryngeal mucous membrane + respiratory mucosa + respiratory tract mucosa + UBERON:0004785 + + respiratory system mucosa + + + + + the mucous membrane lining the respiratory tract + MESH:A04.760 + MGI:cwg + MP:0002277 + + + + + EMAPA:37577 + MA:th + + + + + apparatus respiratorius mucosa + OBOL:automatic + + + + + apparatus respiratorius mucosa of organ + OBOL:automatic + + + + + apparatus respiratorius mucous membrane + OBOL:automatic + + + + + mucosa of apparatus respiratorius + OBOL:automatic + + + + + mucosa of organ of apparatus respiratorius + OBOL:automatic + + + + + mucosa of organ of respiratory system + OBOL:automatic + + + + + mucosa of respiratory system + OBOL:automatic + + + + + mucous membrane of apparatus respiratorius + OBOL:automatic + + + + + mucous membrane of respiratory system + OBOL:automatic + + + + + respiratory system mucosa of organ + OBOL:automatic + + + + + respiratory system mucous membrane + OBOL:automatic + + + + + laryngeal mucous membrane + EMAPA:18334 + + + + + respiratory mucosa + BTO:0000973 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any of the tissue layers that comprise a blood vessel. Examples: tunica media, tunica adventitia. + EMAPA:36296 + MA:0002854 + uberon + UBERON:0004797 + blood vessel layer + Blood:vessels.svg + + + + + Any of the tissue layers that comprise a blood vessel. Examples: tunica media, tunica adventitia. + + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of a respiratory system [Automatically generated definition]. + CALOHA:TS-0023 + EMAPA:32826 + MA:0001823 + VHOG:0000981 + apparatus respiratorius epithelial tissue + apparatus respiratorius epithelium + epithelial tissue of apparatus respiratorius + epithelial tissue of respiratory system + epithelium of apparatus respiratorius + epithelium of respiratory system + respiratory system epithelial tissue + uberon + UBERON:0004807 + + respiratory system epithelium + + + + + An epithelium that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + + + + + apparatus respiratorius epithelial tissue + OBOL:automatic + + + + + apparatus respiratorius epithelium + OBOL:automatic + + + + + epithelial tissue of apparatus respiratorius + OBOL:automatic + + + + + epithelial tissue of respiratory system + OBOL:automatic + + + + + epithelium of apparatus respiratorius + OBOL:automatic + + + + + epithelium of respiratory system + OBOL:automatic + + + + + respiratory system epithelial tissue + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + An endothelium of artery that is part of a respiratory system [Automatically generated definition]. + EMAPA:37566 + MA:0001801 + apparatus respiratorius arterial endothelium + apparatus respiratorius artery endothelium + apparatus respiratorius endothelium of artery + arterial endothelium of apparatus respiratorius + arterial endothelium of respiratory system + artery endothelium of apparatus respiratorius + artery endothelium of respiratory system + endothelium of artery of apparatus respiratorius + endothelium of artery of respiratory system + respiratory system artery endothelium + respiratory system endothelium of artery + uberon + UBERON:0004848 + respiratory system arterial endothelium + + + + + + + + + + + true + + + + + + An endothelium of artery that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + + + + + EMAPA:37566 + MA:th + + + + + apparatus respiratorius arterial endothelium + OBOL:automatic + + + + + apparatus respiratorius artery endothelium + OBOL:automatic + + + + + apparatus respiratorius endothelium of artery + OBOL:automatic + + + + + arterial endothelium of apparatus respiratorius + OBOL:automatic + + + + + arterial endothelium of respiratory system + OBOL:automatic + + + + + artery endothelium of apparatus respiratorius + OBOL:automatic + + + + + artery endothelium of respiratory system + OBOL:automatic + + + + + endothelium of artery of apparatus respiratorius + OBOL:automatic + + + + + endothelium of artery of respiratory system + OBOL:automatic + + + + + respiratory system artery endothelium + OBOL:automatic + + + + + respiratory system endothelium of artery + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + An endothelium of vein that is part of a respiratory system [Automatically generated definition]. + EMAPA:37585 + MA:0001811 + apparatus respiratorius endothelium of vein + apparatus respiratorius vein endothelium + apparatus respiratorius venous endothelium + endothelium of vein of apparatus respiratorius + endothelium of vein of respiratory system + respiratory system endothelium of vein + respiratory system vein endothelium + vein endothelium of apparatus respiratorius + vein endothelium of respiratory system + venous endothelium of apparatus respiratorius + venous endothelium of respiratory system + uberon + UBERON:0004849 + respiratory system venous endothelium + + + + + An endothelium of vein that is part of a respiratory system [Automatically generated definition]. + OBOL:automatic + + + + + EMAPA:37585 + MA:th + + + + + apparatus respiratorius endothelium of vein + OBOL:automatic + + + + + apparatus respiratorius vein endothelium + OBOL:automatic + + + + + apparatus respiratorius venous endothelium + OBOL:automatic + + + + + endothelium of vein of apparatus respiratorius + OBOL:automatic + + + + + endothelium of vein of respiratory system + OBOL:automatic + + + + + respiratory system endothelium of vein + OBOL:automatic + + + + + respiratory system vein endothelium + OBOL:automatic + + + + + vein endothelium of apparatus respiratorius + OBOL:automatic + + + + + vein endothelium of respiratory system + OBOL:automatic + + + + + venous endothelium of apparatus respiratorius + OBOL:automatic + + + + + venous endothelium of respiratory system + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + An endothelium that is part of the cardiovascular system. + consider merging with 'endothelium' + Vertebrates and a very few invertebrates such as squids have evolved a secondary epithelium, the endothelium, that lines their blood vessels.[well established][VHOG] + + BTO:0001853 + EMAPA:35201 + GAID:519 + MA:0000717 + MESH:D004730 + NCIT:C13053 + TAO:0002171 + UMLS:C0014261 + VHOG:0001217 + XAO:0000356 + ZFA:0001639 + uberon + endothelia + vascular endothelia + UBERON:0004852 + + cardiovascular system endothelium + + + + + An endothelium that is part of the cardiovascular system. + + + + + + Vertebrates and a very few invertebrates such as squids have evolved a secondary epithelium, the endothelium, that lines their blood vessels.[well established][VHOG] + 2012-09-17 + VHOG:0001217 + VHOG + + ISBN:978-0030259821 Ruppert EE, Fox RS, Barnes RD, Invertebrate zoology: a functional evolutionary approach (2003) p.207 + + + + + UMLS:C0014261 + ncithesaurus:Vascular_Endothelium + + + + + endothelia + ZFA:0001639 + + + + + + vascular endothelia + XAO:0000356 + + + + + + + + + + + + + + + + + + + + + + + + + + + A gland that is part of a eye. The eye is a compound unit which depending on the species may consist of an eyeballs plus associated ducts and integumentary structures. Eye glands therefore include the various types of lacrimal gland, the various types of apocrine and sebaceous glands associated with the eyelid. + EMAPA:35334 + MA:0000267 + eye-associated gland + gland of eye + uberon + UBERON:0004859 + + Examples: harderian gland, accessory lacrimal gland, gland of Moll, gland of Zeis, nictitating membrane glands + eye gland + + + + + A gland that is part of a eye. The eye is a compound unit which depending on the species may consist of an eyeballs plus associated ducts and integumentary structures. Eye glands therefore include the various types of lacrimal gland, the various types of apocrine and sebaceous glands associated with the eyelid. + + + + + + eye-associated gland + + + + + + gland of eye + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + A vasculature that is part of a retina [Automatically generated definition]. + FMA:76552 + MESH:D012171 + XAO:0004153 + retina vasculature + retina vasculature of camera-type eye + retinal blood vessels + retinal blood vessels set + retinal vasculature + set of blood vessels of retina + set of retinal blood vessels + vasa sanguinea retinae + uberon + UBERON:0004864 + + vasculature of retina + + + + + A vasculature that is part of a retina [Automatically generated definition]. + OBOL:automatic + + + + + retina vasculature + GO:0061298 + + + + + retina vasculature of camera-type eye + GO:0061298 + + + + + retinal blood vessels + FMA:76552 + + + + + retinal blood vessels set + FMA:76552 + + + + + retinal vasculature + OBOL:automatic + + + + + set of blood vessels of retina + OBOL:automatic + + + + + set of retinal blood vessels + FMA:76552 + + + + + vasa sanguinea retinae + FMA:76552 + FMA:TA + + + + + + + + + + + + + + + + + Layer of lateral plate mesoderm that forms the circulatory system and future gut wall - overlies endoderm[WP]. + We group the BILA class here. Considering adding more general class for metazoa grouping cardiogenic successors + visceral mesoderm + + AAO:0011102 + BILA:0000044 + FMA:295568 + XAO:0000276 + inner layer of lateral plate mesoderm + uberon + splanchnic mesoderm + UBERON:0004872 + + splanchnic layer of lateral plate mesoderm + + + + + Layer of lateral plate mesoderm that forms the circulatory system and future gut wall - overlies endoderm[WP]. + + + + + + We group the BILA class here. Considering adding more general class for metazoa grouping cardiogenic successors + BILA + + + + + visceral mesoderm + + + BILA:0000044 + + + + + splanchnic mesoderm + ISBN:9780878932504 + + + + + + + + + + + + + + + + The central region of trunk mesoderm. This tissue forms the notochord + Notochord rudiment[ZFIN:ZDB-PUB-961014-576]. + WP treats this as synonym of axial mesoderm. Induces neural tube. Gilbert: contains an anterior head process and the notochord. + AAO:0000478 + EFO:0003426 + TAO:0000091 + ZFA:0000091 + axial chorda mesoderm + chorda mesoderm + dorsal mesoderm + presumptive notochord + uberon + UBERON:0004880 + + + chordamesoderm + + + + + The central region of trunk mesoderm. This tissue forms the notochord + + + + + + Notochord rudiment[ZFIN:ZDB-PUB-961014-576]. + ZFIN:ZDB-PUB-961014-576 + + + + + axial chorda mesoderm + ZFA:0000091 + + + + + dorsal mesoderm + + + + + + presumptive notochord + ZFA:0000091 + + + + + + + + + + + + + + + Anatomical cluster that connects two or more adjacent skeletal elements or hardened body parts. + FBbt:00005811 + joint + uberon + UBERON:0004905 + + articulation + + + + + Anatomical cluster that connects two or more adjacent skeletal elements or hardened body parts. + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of the gut that is derived from ectoderm. + ectodermal gut + gut ectoderm + uberon + UBERON:0004906 + ectodermal part of digestive tract + + + + + A portion of the gut that is derived from ectoderm. + GO:0007439 + + + + + gut ectoderm + EMAPA:32930 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A proximal-distal subdivision of the digestive tract. + intended to denote both embryonic and adult structures. Note the FMA grouping here is not quite correct. + FBbt:00100315 + FMA:71131 + uberon + alimentary system subdivision + intestinal tract + segment of intestinal tract + subdivision of alimentary system + UBERON:0004921 + + subdivision of digestive tract + + + + + A proximal-distal subdivision of the digestive tract. + + + + + + alimentary system subdivision + FMA:71131 + + + + + subdivision of alimentary system + FMA:71131 + + + + + + + + + + + + + + + A part of a wall of an organ that forms a layer. + FMA:82485 + uberon + UBERON:0004923 + + organ component layer + + + + + A part of a wall of an organ that forms a layer. + + + + + + + + + + + + + + + + + + + + + + + + + + + + The tissue underlying the tunica mucosa of the pharynx. + + BTO:0002113 + FMA:75144 + pharyngeal submucosa + pharynx submucosa + tela submucosa pharyngea + tela submucosa pharyngis + uberon + pharyngobasilar fascia + submucous coat of pharynx + submucous layer of pharynx + UBERON:0004924 + submucosa of pharynx + + + + + The tissue underlying the tunica mucosa of the pharynx. + BTO:0002113 + + + + + pharyngeal submucosa + FMA:75144 + + + + + pharynx submucosa + OBOL:automatic + + + + + tela submucosa pharyngea + FMA:75144 + FMA:TA + + + + + + tela submucosa pharyngis + BTO:0002113 + + + + + + submucous coat of pharynx + BTO:0002113 + + + + + submucous layer of pharynx + BTO:0002113 + + + + + + + + + + + + + + + + + + + + + + + + + + + A mucosa that is part of a lower lip [Automatically generated definition]. + + + FMA:59833 + NCIT:C12225 + UMLS:C0226939 + lower labial mucosa + lower lip mucosa + lower lip mucosa of organ + lower lip mucous membrane + lower lip organ mucosa + mucosa of organ of lower lip + mucous membrane of lower lip + organ mucosa of lower lip + uberon + UBERON:0005032 + mucosa of lower lip + + + + + A mucosa that is part of a lower lip [Automatically generated definition]. + OBOL:automatic + + + + + UMLS:C0226939 + ncithesaurus:Mucosa_of_the_Lower_Lip + + + + + lower labial mucosa + UBERON:cjm + + + + + lower lip mucosa + OBOL:automatic + + + + + lower lip mucosa of organ + OBOL:automatic + + + + + lower lip mucous membrane + OBOL:automatic + + + + + lower lip organ mucosa + OBOL:automatic + + + + + mucosa of organ of lower lip + OBOL:automatic + + + + + mucous membrane of lower lip + OBOL:automatic + + + + + organ mucosa of lower lip + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A gland that is part of a hemolymphoid system [Automatically generated definition]. + hemopoietic or lymphoid organ + EMAPA:18766 + MA:0002962 + hemopoietic or lymphoid gland + uberon + haemolymphoid system gland + UBERON:0005058 + + hemolymphoid system gland + + + + + A gland that is part of a hemolymphoid system [Automatically generated definition]. + OBOL:automatic + + + + + hemopoietic or lymphoid organ + GO:0048534 + + + + + hemopoietic or lymphoid gland + + + + + + haemolymphoid system gland + EMAPA:18766 + + + + + + + + + + + + + + + + The median dorsal longitudinal groove formed in the embryo by the neural plate after the appearance of the neural folds. + The neural groove is a shallow median groove between the neural folds of an embryo. The neural folds are two longitudinal ridges that are caused by a folding up of the ectoderm in front of the primitive streak of the developing embryo. The groove gradually deepens as the neural folds become elevated, and ultimately the folds meet and coalesce in the middle line and convert the groove into a closed tube, the neural tube or canal, the ectodermal wall of which forms the rudiment of the nervous system. After the coalescence of the neural folds over the anterior end of the primitive streak, the blastopore no longer opens on the surface but into the closed canal of the neural tube, and thus a transitory communication, the neurenteric canal, is established between the neural tube and the primitive digestive tube. The coalescence of the neural folds occurs first in the region of the hind-brain, and from there extends forward and backward; toward the end of the third week the front opening (anterior neuropore) of the tube finally closes at the anterior end of the future brain, and forms a recess which is in contact, for a time, with the overlying ectoderm; the hinder part of the neural groove presents for a time a rhomboidal shape, and to this expanded portion the term sinus rhomboidalis has been applied. Before the neural groove is closed a ridge of ectodermal cells appears along the prominent margin of each neural fold; this is termed the neural crest or ganglion ridge, and from it the spinal and cranial nerve ganglia and the ganglia of the sympathetic nervous system are developed. By the upward growth of the mesoderm the neural tube is ultimately separated from the overlying ectoderm. The cephalic end of the neural groove exhibits several dilatations, which, when the tube is closed, assume the form of three vesicles; these constitute the three primary cerebral vesicles, and correspond respectively to the future fore-brain (prosencephalon), mid-brain (mesencephalon), and hind-brain (rhombencephalon). The walls of the vesicles are developed into the nervous tissue and neuroglia of the brain, and their cavities are modified to form its ventricles. The remainder of the tube forms the medulla spinalis or spinal cord; from its ectodermal wall the nervous and neuroglial elements of the medulla spinalis are developed while the cavity persists as the central canal[Wikipedia:Neural_groove]. + + + + + AAO:0011071 + EMAPA:35594 + FMA:295624 + NCIT:C34224 + UMLS:C0814992 + XAO:0000248 + uberon + UBERON:0005061 + neural groove + + + + + The median dorsal longitudinal groove formed in the embryo by the neural plate after the appearance of the neural folds. + + + GO:0001842 + + + + + The neural groove is a shallow median groove between the neural folds of an embryo. The neural folds are two longitudinal ridges that are caused by a folding up of the ectoderm in front of the primitive streak of the developing embryo. The groove gradually deepens as the neural folds become elevated, and ultimately the folds meet and coalesce in the middle line and convert the groove into a closed tube, the neural tube or canal, the ectodermal wall of which forms the rudiment of the nervous system. After the coalescence of the neural folds over the anterior end of the primitive streak, the blastopore no longer opens on the surface but into the closed canal of the neural tube, and thus a transitory communication, the neurenteric canal, is established between the neural tube and the primitive digestive tube. The coalescence of the neural folds occurs first in the region of the hind-brain, and from there extends forward and backward; toward the end of the third week the front opening (anterior neuropore) of the tube finally closes at the anterior end of the future brain, and forms a recess which is in contact, for a time, with the overlying ectoderm; the hinder part of the neural groove presents for a time a rhomboidal shape, and to this expanded portion the term sinus rhomboidalis has been applied. Before the neural groove is closed a ridge of ectodermal cells appears along the prominent margin of each neural fold; this is termed the neural crest or ganglion ridge, and from it the spinal and cranial nerve ganglia and the ganglia of the sympathetic nervous system are developed. By the upward growth of the mesoderm the neural tube is ultimately separated from the overlying ectoderm. The cephalic end of the neural groove exhibits several dilatations, which, when the tube is closed, assume the form of three vesicles; these constitute the three primary cerebral vesicles, and correspond respectively to the future fore-brain (prosencephalon), mid-brain (mesencephalon), and hind-brain (rhombencephalon). The walls of the vesicles are developed into the nervous tissue and neuroglia of the brain, and their cavities are modified to form its ventricles. The remainder of the tube forms the medulla spinalis or spinal cord; from its ectodermal wall the nervous and neuroglial elements of the medulla spinalis are developed while the cavity persists as the central canal[Wikipedia:Neural_groove]. + + + + + + UMLS:C0814992 + ncithesaurus:Neural_Groove + + + + + + + + + + + + + + + + + + + + + + + + + One of the two elevated edges of the neural groove[GO,MP]. + In front of the primitive streak two longitudinal ridges, caused by a folding up of the ectoderm, make their appearance, one on either side of the middle line. These are named the neural folds; they commence some little distance behind the anterior end of the embryonic disk, where they are continuous with each other, and from there gradually extend backward, one on either side of the anterior end of the primitive streak. Also, after differentiation it turns into the neural tubes[Wikipedia:Neural_fold]. + + + + + EHDAA2:0001249 + FMA:295618 + NCIT:C34223 + UMLS:C0814993 + XAO:0004087 + medullary fold + uberon + UBERON:0005062 + + neural fold + + + + + One of the two elevated edges of the neural groove[GO,MP]. + + GO:0001842 + MP:0011256 + + + + + In front of the primitive streak two longitudinal ridges, caused by a folding up of the ectoderm, make their appearance, one on either side of the middle line. These are named the neural folds; they commence some little distance behind the anterior end of the embryonic disk, where they are continuous with each other, and from there gradually extend backward, one on either side of the anterior end of the primitive streak. Also, after differentiation it turns into the neural tubes[Wikipedia:Neural_fold]. + + + + + + UMLS:C0814993 + ncithesaurus:Neural_Fold + + + + + medullary fold + MP:0011256 + + + + + + + + + + + + + + + A solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts[GO]. An intermediate stage in the development of the central nervous system present during the segmentation period; the neural rod is roughly cylindrical in shape, forms from the neural keel, and is not yet hollowed out into the neural tube[ZFIN]. + An intermediate stage in the development of the central nervous system present during the segmentation period; the neural rod is roughly cylindrical in shape, forms from the neural keel, and is not yet hollowed out into the neural tube. Kimmel et al, 1995.[TAO] + EFO:0003498 + TAO:0000133 + ZFA:0000133 + uberon + neural tube rod + UBERON:0005068 + + neural rod + + + + + A solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts[GO]. An intermediate stage in the development of the central nervous system present during the segmentation period; the neural rod is roughly cylindrical in shape, forms from the neural keel, and is not yet hollowed out into the neural tube[ZFIN]. + GO:0014024 + ZFA:0000133 + + + + + An intermediate stage in the development of the central nervous system present during the segmentation period; the neural rod is roughly cylindrical in shape, forms from the neural keel, and is not yet hollowed out into the neural tube. Kimmel et al, 1995.[TAO] + 2012-08-14 + TAO:0000133 + TAO + ZFIN:curator + + + + + neural tube rod + GO:0014027 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical boundary that adjacent_to a forebrain and adjacent_to a midbrain. + The boundary between the diencephalon and the mesencephalon.[TAO] + relationship loss: develops_from forebrain midbrain boundary neural tube (TAO:0007040)[TAO] + EMAPA:36449 + TAO:0001367 + ZFA:0001367 + diencephalic-mesencephalic boundary + forebrain midbrain boundary + forebrain-midbrain boundary region + uberon + UBERON:0005075 + forebrain-midbrain boundary + + + + + + + + + + + definitional + + + + + An anatomical boundary that adjacent_to a forebrain and adjacent_to a midbrain. + OBOL:automatic + + + + + The boundary between the diencephalon and the mesencephalon.[TAO] + 2012-08-14 + TAO:0001367 + TAO + ZFIN:curator + + + + + relationship loss: develops_from forebrain midbrain boundary neural tube (TAO:0007040)[TAO] + 2012-08-14 + TAO:0001367 + TAO + + + + + diencephalic-mesencephalic boundary + ZFA:0001367 + + + + + forebrain midbrain boundary + ZFA:0001367 + + + + + forebrain-midbrain boundary region + EMAPA:36449 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical boundary that adjacent_to a hindbrain and adjacent_to a spinal cord. + hindbrain-spinal cord boundary region + uberon + UBERON:0005076 + hindbrain-spinal cord boundary + + + + + An anatomical boundary that adjacent_to a hindbrain and adjacent_to a spinal cord. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A hole in a tube[GO]. + AEO:0000078 + EHDAA2:0004618 + RETIRED_EHDAA2:0003078 + uberon + UBERON:0005082 + tube lumen + + + + + A hole in a tube[GO]. + GO:0060609 + + + + + + + + + + + + + + + + + An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm[GO] + consder adding placodal ectoderm as a distinct class? Also place placodal ectoderm as develops_from ectoderm; need to check taxon-appropriateness + With the exception of the adenohypophysis, homologues of the nonneurogenic placodes (e.g. placodes giving rise to the teeth, hair follicles and lens), appear to be lacking in invertebrate chordates. + in GO, covers optic, otic, olfactory, mammary, hair, tooth, sebaceous - and also insect structures + AEO:0000218 + uberon + epithelial placode + UBERON:0005085 + ectodermal placode + + + + + An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm[GO] + GO:0060788 + + + + + in GO, covers optic, otic, olfactory, mammary, hair, tooth, sebaceous - and also insect structures + GO + + + + + + epithelial placode + AEO:0000112 + + + + + + + + + Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms[GO]. + in some organisms such as drosophila, muscles can be single cells. This class groups together all discrete muscle elements, from multicellular muscle organs in vertebrates, to individual single-cell muscles in drisophila + EMAPA:32715 + FBbt:00005073 + FMA:30316 + musculus + uberon + muscle + muscle element + UBERON:0005090 + muscle structure + + + + + Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms[GO]. + GO:0061061 + + + + + musculus + FMA:30316 + + + + + + + + + An epithelial sheet bent on a linear axis. + uberon + UBERON:0005157 + epithelial fold + + + + + An epithelial sheet bent on a linear axis. + GO:0060571 + + + + + + + + + A structure consisting of multiple cell components but which is not itself a cell and does not have (complete) cells as a part. + we go with the FMA classification rather than the CARO one. FMA def: 'Anatomical cluster which has as direct parts cell parts from two or more cells.' + AAO:0011000 + CARO:0001000 + FBbt:00007060 + FMA:83115 + multi-cell-component structure + multi-cell-part structure + uberon + cell part cluster + UBERON:0005162 + + multi cell part structure + + + + + + FMA + + + + + A structure consisting of multiple cell components but which is not itself a cell and does not have (complete) cells as a part. + CARO:0001000 + + + + + we go with the FMA classification rather than the CARO one. FMA def: 'Anatomical cluster which has as direct parts cell parts from two or more cells.' + CARO + FMA + + + + + multi-cell-component structure + CARO:0001000 + + + + + multi-cell-part structure + CARO:0001000 + + + + + cell part cluster + FMA:83115 + + + + + + + + + + + + + + + + + + + + + + + + + + An organ or element that part of the dorsum of the organism. Examples: spinal cord, vertebrae, muscles of back. + EMAPA:37274 + MA:0001901 + back organ + dorsal region organ + uberon + UBERON:0005174 + + dorsal region element + + + + + An organ or element that part of the dorsum of the organism. Examples: spinal cord, vertebrae, muscles of back. + + + + + + EMAPA:37274 + MA:th + + + + + back organ + MA:0001901 + + + + + + + + + + + + + + + + + + + + + + + + + + An organ or element that part of the trunk region. The trunk region can be further subdividied into thoracic (including chest and thoracic cavity) and abdominal (including abdomen and pelbis) regions. + EMAPA:37270 + MA:0000516 + trunk organ + uberon + UBERON:0005177 + + + trunk region element + + + + + An organ or element that part of the trunk region. The trunk region can be further subdividied into thoracic (including chest and thoracic cavity) and abdominal (including abdomen and pelbis) regions. + + + + + + EMAPA:37270 + MA:th + + + + + trunk organ + MA:0000516 + + + + + + + + + + + + + + + + + + + + + + + + + + + An organ or element that is in the thoracic cavity. Examples: lung, heart, longus colli. + EMAPA:37273 + MA:0000557 + thoracic cavity organ + uberon + UBERON:0005178 + + + thoracic cavity element + + + + + An organ or element that is in the thoracic cavity. Examples: lung, heart, longus colli. + + + + + + EMAPA:37273 + MA:th + + + + + thoracic cavity organ + MA:0000557 + + + + + + + + + + + + + + + + + + + + + + + + + + An organ that part of the thoracic segment region. This region can be further subdividied chest and thoracic cavity regions. + EMAPA:37271 + MA:0000563 + uberon + upper body organ + UBERON:0005181 + + thoracic segment organ + + + + + An organ that part of the thoracic segment region. This region can be further subdividied chest and thoracic cavity regions. + + + + + + EMAPA:37271 + MA:th + + + + + upper body organ + MA:0000563 + + + + + + + + + + + + + + + + + + + + + A vein that is part of a thorax [Automatically generated definition]. + + + EMAPA:37197 + MA:0002235 + NCIT:C53142 + UMLS:C0226629 + uberon + UBERON:0005194 + thoracic vein + + + + + A vein that is part of a thorax [Automatically generated definition]. + OBOL:automatic + + + + + EMAPA:37197 + MA:th + + + + + UMLS:C0226629 + ncithesaurus:Thoracic_Vein + + + + + + + + + + + + + + + + + + + + + + + + + + An external ectoderm that is part of a optic eminence [Automatically generated definition]. + EMAPA:16539 + RETIRED_EHDAA2:0001311 + VHOG:0000520 + uberon + UBERON:0005216 + optic eminence surface ectoderm + + + + + + + + + + + true + + + + + + An external ectoderm that is part of a optic eminence [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + An ectoderm that is part of a optic eminence [Automatically generated definition]. + EHDAA:940 + EMAPA:16539 + RETIRED_EHDAA2:0001309 + VHOG:0001105 + uberon + UBERON:0005234 + optic eminence ectoderm + + + + + An ectoderm that is part of a optic eminence [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + A gland that is part of a stomodeum. + check this + VHOG:0000658 + stomatodaeum gland + uberon + UBERON:0005250 + + stomatodeum gland + + + + + A gland that is part of a stomodeum. + OBOL:automatic + + + + + stomatodaeum gland + VHOG:0000658 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Portion of primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells. + Mesoderm that will give rise, along with cranial neural crest cells, to connective tissue, bone and musculature in the head. (Source: BioGlossary, www.Biology-Text.com)[TAO] + EFO:0003492 + EHDAA2:0000732 + EHDAA:179 + EMAPA:16098 + EMAPA_RETIRED:16269 + FMA:76622 + TAO:0000113 + VHOG:0000332 + ZFA:0000113 + cephalic mesenchyme + uberon + cranial mesenchyme + desmocranium + UBERON:0005253 + + + + head mesenchyme + + + + + + + + + + + EHDAA2 + + + + + Portion of primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells. + ISBN:0683400088 + MP:0011260 + + + + + Mesoderm that will give rise, along with cranial neural crest cells, to connective tissue, bone and musculature in the head. (Source: BioGlossary, www.Biology-Text.com)[TAO] + 2012-08-14 + TAO:0000113 + TAO + ZFIN:curator + + + + + cephalic mesenchyme + MP:0011260 + + + + + cranial mesenchyme + MGI:anna + + + + + desmocranium + FMA:76622 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Mesenchyme that is part of a developing trunk. + EFO:0003485 + EHDAA2:0002092 + EHDAA:377 + EMAPA:16177 + TAO:0000081 + VHOG:0000281 + ZFA:0000081 + uberon + trunk and cervical mesenchyme + UBERON:0005256 + + + trunk mesenchyme + + + + + + + + + + + EHDAA2 + + + + + Mesenchyme that is part of a developing trunk. + OBOL:automatic + + + + + trunk and cervical mesenchyme + EHDAA2:0002092 + + + + + + + + + + + + + + + + + + + + + The posterior part of the developing vertebrate hindbrain or the corresponding part of the adult brain composed of the medulla oblongata and a portion of the fourth ventricle; as well as the glossopharyngeal nerve (CN IX), vagus nerve (CN X), accessory nerve (CN XI), hypoglossal nerve (CN XII), and a portion of the vestibulocochlear nerve (CN VIII).[BTO,WP]. + + The posterior of the two brain vesicles formed by specialization of the rhombencephalon in the developing embryo, it comprises the medulla oblongata. [TFD][VHOG] + The early development of most vertebrate brains is similar (...). The zebrafish neural tube follows the same basic differentiation pattern as the mammalian neural tube (reference 1); The brain develops from three embryonic enlargements of the neural tube, which later differentiate into five regions. A forebrain differentiates into telencephalon and diencephalon. The midbrain, or mesencephalon, remains undivided. The hindbrain divides into the metencephalon and myelencephalon. Cavities within the brain enlarge to form a series of interconnected ventricles (reference 2).[well established][VHOG] + the terms metencephalon and myelencephalon are only meaningful in mammals and birds - Neuroanatomy of the Zebrafish Brain. Note that its not clear if this refers to the developing medulla oblongata - MA (adult) has two distinct classes + + BTO:0000758 + CALOHA:TS-0607 + CALOHA:TS-2365 + DHBA:10662 + EHDAA2:0001207 + EHDAA:5526 + EMAPA:17082 + HBA:9512 + MA:0000205 + VHOG:0000456 + uberon + myelencephalon (medulla oblongata) + UBERON:0005290 + + myelencephalon + http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg + + + + + + + + + + + definitional + + + + + The posterior part of the developing vertebrate hindbrain or the corresponding part of the adult brain composed of the medulla oblongata and a portion of the fourth ventricle; as well as the glossopharyngeal nerve (CN IX), vagus nerve (CN X), accessory nerve (CN XI), hypoglossal nerve (CN XII), and a portion of the vestibulocochlear nerve (CN VIII).[BTO,WP]. + + BTO:0000758 + + + + + The posterior of the two brain vesicles formed by specialization of the rhombencephalon in the developing embryo, it comprises the medulla oblongata. [TFD][VHOG] + 2012-09-17 + VHOG:0000456 + VHOG + + + + + + + The early development of most vertebrate brains is similar (...). The zebrafish neural tube follows the same basic differentiation pattern as the mammalian neural tube (reference 1); The brain develops from three embryonic enlargements of the neural tube, which later differentiate into five regions. A forebrain differentiates into telencephalon and diencephalon. The midbrain, or mesencephalon, remains undivided. The hindbrain divides into the metencephalon and myelencephalon. Cavities within the brain enlarge to form a series of interconnected ventricles (reference 2).[well established][VHOG] + 2012-09-17 + VHOG:0000456 + VHOG + + ISBN:978-0878932504 Gilbert SF, Developmental Biology (2006) p.381-382, ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.500 + + + + + myelencephalon (medulla oblongata) + DHBA:10662 + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of tissue that is part of an embryo. + CALOHA:TS-2100 + portion of embryonic tissue + uberon + developing tissue + UBERON:0005291 + + + embryonic tissue + + + + + A portion of tissue that is part of an embryo. + OBOL:automatic + + + + + portion of embryonic tissue + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + Portion of tissue that is contiguous with the embryo and is comprised of portions of tissue or cells that will not contribute to the embryo. + BTO:0003360 + CALOHA:TS-2119 + EFO:0001406 + MAT:0000061 + MIAA:0000061 + extra-embryonic tissue + uberon + UBERON:0005292 + + extraembryonic tissue + + + + + Portion of tissue that is contiguous with the embryo and is comprised of portions of tissue or cells that will not contribute to the embryo. + + + + + + + + + + + + + + + + + + + + + + + + + + + The endothelial lining of the endocardium. + FMA:83596 + endocardium endothelium + endothelium of endocardium + uberon + UBERON:0005316 + endocardial endothelium + + + + + The endothelial lining of the endocardium. + UBERON:cjm + + + + + endocardium endothelium + FMA:83596 + + + + + endothelium of endocardium + FMA:83596 + + + + + + + + + + + + + + + + + + + + + + + + + + + A lamina propria that is part of a mucosa of oral region. + EMAPA:26947 + lamina propria of oral mucosa + uberon + UBERON:0005334 + oral lamina propria + + + + + A lamina propria that is part of a mucosa of oral region. + OBOL:automatic + + + + + + + + + + + + + + + The outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers[MP]. + A single stem cell in the ventricular layer can give rise to neurons (and glial cells) in any of the cortical layers (Walsh and Cepko 1988)[NCBIBook:NBK10047] + in humans develops into cortical layers II-VI + CP + CxP + + BAMS:CTXpl + DHBA:10515 + EMAPA:32711 + MBA:695 + PBA:294021914 + cerebral cortex cortical plate + future cortical layers II-VI + neocortex cortical plate + uberon + future neocortex + UBERON:0005343 + + cortical plate + + + + + + + + + + + NCBIBook:NBK10047 + + + + + The outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers[MP]. + + MP:0008439 + + + + + CP + BRAINSPAN:BRAINSPAN + + + + + + CxP + + + + + + + future cortical layers II-VI + + + + + + future neocortex + + + + + + + + + + + + + + + + + + + + + + + An array of photoreceptors and any supporting cells found in an eye. + FBbt:00004200 + light-sensitive tissue + uberon + UBERON:0005388 + photoreceptor array + + + + + An array of photoreceptors and any supporting cells found in an eye. + + + + + + + + + + + + + + + + A transparent structure that is part of a visual sense organ, the function of which is to direct or focus light onto a photoreceptor array. + directing or focusing light onto light receptors + lens + uberon + UBERON:0005389 + + transparent eye structure + + + + + A transparent structure that is part of a visual sense organ, the function of which is to direct or focus light onto a photoreceptor array. + + + + + + + + + + + + + + + + + + + + + + + + + + + A gray matter that is part of a cerebral hemisphere. + BTO may actually be a more generic structure; FMA may represent a more specific structure. Consider merging with gray matter of telencephalon + BTO:0000823 + CALOHA:TS-2361 + EMAPA:37477 + FMA:61821 + MA:0000944 + cerebral gray matter + cerebral grey matter + cerebral hemisphere grey matter + uberon + UBERON:0005401 + cerebral hemisphere gray matter + + + + + A gray matter that is part of a cerebral hemisphere. + OBOL:automatic + + + + + BTO may actually be a more generic structure; FMA may represent a more specific structure. Consider merging with gray matter of telencephalon + BTO + + + + + EMAPA:37477 + MA:th + + + + + cerebral gray matter + BTO:0000823 + + + + + cerebral grey matter + MA:0000944 + + + + + + + + + AEO:0000125 + CALOHA:TS-2122 + EHDAA2:0003125 + FBbt:00007006 + FMA:292313 + MIAA:0000019 + uberon + developing structure + developmental structure + developmental tissue + UBERON:0005423 + developing anatomical structure + + + + + developmental tissue + MIAA:0000019 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Portion of tissue that is the inner layer of the optic cup and will become the neural retina. + (...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG] + EHDAA2:0001304 + EMAPA:16675 + TAO:0001071 + VHOG:0000490 + ZFA:0001071 + future neural retina + future retinal neural layer + inner layer optic cup + optic cup inner layer + presumptive retinas + uberon + future NR + future neural epithelium + future neural layer + presumptive retina + UBERON:0005425 + + presumptive neural retina + + + + + Portion of tissue that is the inner layer of the optic cup and will become the neural retina. + ZFIN:curator + + + + + (...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG] + 2012-09-17 + VHOG:0000490 + VHOG + + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429 + + + + + inner layer optic cup + ZFA:0001071 + + + + + optic cup inner layer + EHDAA2:0001304 + + + + + presumptive retinas + ZFA:0001071 + + + + + + future neural epithelium + EMAPA:16675 + + + + + future neural layer + EMAPA:16675 + + + + + presumptive retina + TAO:0001071 + + + + + + + + + + + + + + + + Portion of tissue that gives rise to the lens. + A vesicle formed from the lens pit of the embryo, developing into the crystalline lens. [TFD][VHOG] + (...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The optic cup induces the overlying surface ectoderm first to thicken as a lens placode and then to invaginate and form a lens vesicle that differentiates into the lens.[well established][VHOG] + the lens of zebrafish (and other teleosts) forms from delamination of cells from the lens placode; thus, there is no formation of a hollow lens vesicle, in contrast to the situation in mammals and birds (Glass and Dahm, 2004) [PMID:16496288] The lens of the zebrafish forms by delamination of lens placodal cells and not through invagination. This results in a solid spherical mass as opposed to a hollow lens vesicle. Detachment of the solid lens vesicle of zebrafish at 24b26 hpf is accomplished in part by apoptosis, similar to mammals + + EHDAA2:0000983 + EHDAA:4737 + EMAPA:17163 + TAO:0002205 + VHOG:0001163 + ZFA:0001679 + hollow lens vesicle + solid lens vesicle + uberon + immature lens + lens mass + presumptive lens + UBERON:0005426 + + + lens vesicle + + + + + Portion of tissue that gives rise to the lens. + + ZFIN:curator + + + + + A vesicle formed from the lens pit of the embryo, developing into the crystalline lens. [TFD][VHOG] + 2012-09-17 + VHOG:0001163 + VHOG + + + + + + + (...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The optic cup induces the overlying surface ectoderm first to thicken as a lens placode and then to invaginate and form a lens vesicle that differentiates into the lens.[well established][VHOG] + 2012-09-17 + VHOG:0001163 + VHOG + + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429 + + + + + the lens of zebrafish (and other teleosts) forms from delamination of cells from the lens placode; thus, there is no formation of a hollow lens vesicle, in contrast to the situation in mammals and birds (Glass and Dahm, 2004) [PMID:16496288] The lens of the zebrafish forms by delamination of lens placodal cells and not through invagination. This results in a solid spherical mass as opposed to a hollow lens vesicle. Detachment of the solid lens vesicle of zebrafish at 24b26 hpf is accomplished in part by apoptosis, similar to mammals + ZFA + + + + + hollow lens vesicle + + + + + + solid lens vesicle + ZFA:0001679 + + + + + + immature lens + ZFA:0001679 + + + + + lens mass + ZFA:0001679 + ZFIN:ZDB-PUB-091023-49 + + + + + presumptive lens + ZFA:0001679 + + + + + + + + + + + + + + + + + + Portion of tissue that is part of the eye and gives rise to the mature, fully layered cornea. + TAO:0002188 + ZFA:0001688 + uberon + UBERON:0005427 + corneal primordium + + + + + + ZFA + + + + + + Obol + + + + + + + + + + + ZFA + + + + + Portion of tissue that is part of the eye and gives rise to the mature, fully layered cornea. + ZFIN:ZDB-PUB-061010-3 + + + + + + + + + + + + + + + Portion of tissue on the side of the lumen of the neural tube. + EHDAA2:0001257 + EHDAA:2873 + EHDAA:912 + EMAPA:16166 + TAO:0001435 + VHOG:0000513 + ZFA:0001435 + lateral wall neural tube + uberon + UBERON:0005496 + + neural tube lateral wall + + + + + Portion of tissue on the side of the lumen of the neural tube. + ZFA:0001435 + + + + + lateral wall neural tube + ZFA:0001435 + + + + + + + + + + + + + + + + + + + + + + Multi-tissue structure that arises from the heart rudiment and will become the heart tube. + + + EHDAA2:0001512 + EHDAA:424 + EHDAA:436 + EMAPA:16215 + FMA:321916 + TAO:0000149 + ZFA:0000149 + primitive heart tube + early primitive heart tube + uberon + UBERON:0005498 + + primitive heart tube + + + + + + + + + + + ZFA + + + + + Multi-tissue structure that arises from the heart rudiment and will become the heart tube. + ZFA:0000149 + + + + + primitive heart tube + EMAPA:16215 + + + + + early primitive heart tube + EMAPA:16208 + + + + + + + + + + + + + + + + + + + + + + + + + + A neural tube lateral wall that is part of a rhombomere. + EMAPA:32819 + EMAPA:35364 + uberon + future hindbrain lateral wall + UBERON:0005501 + rhombomere lateral wall + + + + + A neural tube lateral wall that is part of a rhombomere. + OBOL:automatic + + + + + future hindbrain lateral wall + EMAPA:35364 + + + + + + + + + + + + + + + + + + + + + + + + + + A somite that is part of a trunk. + AAO:0010385 + EHDAA2:0003438 + EMAPA:16184 + XAO:0000314 + uberon + UBERON:0005598 + trunk somite + + + + + A somite that is part of a trunk. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A layer of cuboidal epithelial cells bounded anteriorly by the capsule of the lens and posteriorly by the lens cortex. + Cells of the subcapsular epithelium (or anterior lens cells) are mitotically active. In adult individuals they only cover the anterior 'hemisphere' of the lens. As they divide, cells gradually move towards the equator of the lens where they tranform into lens fibres. The apical part of the gradually elongating cell extends between the subcapsular epithelium and adjacent lens fibres towards the anterior pole of the lens. The basal part extends towards the posterior pole. The nucleus remains close to the equatorial plane of the lens - http://www.lab.anhb.uwa.edu.au/mb140/corepages/eye/eye.htm + lens epithelium + + + EHDAA2:0000984 + EHDAA:9059 + EMAPA:17304 + EMAPA:17839 + FMA:70612 + MA:0001302 + NCIT:C33641 + RETIRED_EHDAA2:0000976 + UMLS:C1182652 + VHOG:0001425 + lens subcapsular epithelium + subcapsular lens epithelium + uberon + anterior epithelium of lens vesicle + anterior surface of lens + UBERON:0005614 + lens anterior epithelium + + + + + A layer of cuboidal epithelial cells bounded anteriorly by the capsule of the lens and posteriorly by the lens cortex. + + + + + + UMLS:C1182652 + ncithesaurus:Subcapsular_Epithelium_of_the_Lens + + + + + lens subcapsular epithelium + + + + + + subcapsular lens epithelium + FMA:70612 + + + + + anterior epithelium of lens vesicle + EMAPA:17304 + + + + + anterior surface of lens + FMA:58889 + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of a anterior chamber of eyeball. + EHDAA2:0000130 + uberon + UBERON:0005638 + anterior chamber epithelium + + + + + An epithelium that is part of a anterior chamber of eyeball. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of a lens vesicle. + EHDAA2:0000987 + EMAPA:17165 + VHOG:0000532 + uberon + UBERON:0005656 + lens vesicle epithelium + + + + + An epithelium that is part of a lens vesicle. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical cavity that is part of a lens vesicle. + (...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The optic cup induces the overlying surface ectoderm first to thicken as a lens placode and then to invaginate and form a lens vesicle that differentiates into the lens.[well established][VHOG] + cavity of lens + lens cavity + EHDAA2:0000986 + EMAPA:17164 + VHOG:0000531 + cavity of lens vesicle + uberon + UBERON:0005688 + lens vesicle cavity + + + + + An anatomical cavity that is part of a lens vesicle. + OBOL:automatic + + + + + (...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The optic cup induces the overlying surface ectoderm first to thicken as a lens placode and then to invaginate and form a lens vesicle that differentiates into the lens.[well established][VHOG] + 2012-09-17 + VHOG:0000531 + VHOG + + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429 + + + + + lens cavity + EHDAA2:0000986 + + + + + cavity of lens vesicle + EMAPA:17164 + + + + + + + + + + + + + + + + + + + + + + + + + + + Mesenchyme that is part of a optic eminence. + EHDAA:942 + EMAPA:16324 + RETIRED_EHDAA2:0001310 + VHOG:0001073 + uberon + UBERON:0005702 + optic eminence mesenchyme + + + + + Mesenchyme that is part of a optic eminence. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + A venous system that is part of a hindbrain. + EHDAA2:0000776 + EMAPA:18632 + VHOG:0001322 + uberon + rhombencephalon venous system + UBERON:0005720 + hindbrain venous system + + + + + A venous system that is part of a hindbrain. + OBOL:automatic + + + + + rhombencephalon venous system + VHOG:0001322 + + + + + + + + + + + + + + + + The outermost layer of a blood vessel, composed mainly of fibrous tissue. + TODO - note terminological problems. WP says tunica external layer of blood vessel. FMA says tunica externa = adventitia, and is FMA adventitia covers other kinds of vessels. Here we opt for a lengthier name that attempts to disambiguate. There is no precise FMA equivalent, as FMA has tunica externa of arteries, veins, genital ducts etc as siblings + The outermost layer of a blood vessel, surrounding the tunica media. It is mainly composed of collagen. The collagen serves to anchor the blood vessel to nearby organs, giving it stability[Wikipedia:Tunica_externa_(vessels)]. + + + + BTO:0002010 + EMAPA:36299 + NCIT:C33818 + UMLS:C0225342 + adventitia externa + tunica adventitia + tunica adventitia of vessel + uberon + external coat + tunica adventitia vasorum + tunica externa vasorum + UBERON:0005734 + tunica adventitia of blood vessel + Illu:artery.jpg + + + + + + cjm + + + + + The outermost layer of a blood vessel, composed mainly of fibrous tissue. + + ISBN:0073040584 + + + + + The outermost layer of a blood vessel, surrounding the tunica media. It is mainly composed of collagen. The collagen serves to anchor the blood vessel to nearby organs, giving it stability[Wikipedia:Tunica_externa_(vessels)]. + + + + + + UMLS:C0225342 + ncithesaurus:Tunica_Adventitia + + + + + adventitia externa + + + + + + tunica adventitia + + + + + + tunica adventitia of vessel + + + + + + external coat + + + + + + tunica adventitia vasorum + + + + + + + tunica externa vasorum + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A tunica intima that is part of a artery. + + EMAPA:36293 + EV:0100028 + FMA:14272 + galen:IntimaOfArtery + arterial intima + tunica interna (intima)(arteriae) + uberon + UBERON:0005740 + tunica intima of artery + + + + + A tunica intima that is part of a artery. + OBOL:automatic + + + + + arterial intima + EV:0100028 + + + + + tunica interna (intima)(arteriae) + FMA:14272 + + + + + + + + + + + + + + + An outermost connective tissue covering of an organ, vessel, or other structure[WP]. + + + BTO:0002010 + FMA:45635 + tunica advetitia + tunica externa + uberon + UBERON:0005742 + + adventitia + http://upload.wikimedia.org/wikipedia/commons/e/e8/Illu_esophageal_layers.jpg + + + + + An outermost connective tissue covering of an organ, vessel, or other structure[WP]. + + + + + + tunica advetitia + + + + + + tunica externa + FMA:45635 + + + + + + + + + + + + + + + + + + + + + + + + + + A acellular anatomical structure that is the bounding layer of a anatomical structure. + FMA:63871 + uberon + UBERON:0005764 + acellular membrane + + + + + A acellular anatomical structure that is the bounding layer of a anatomical structure. + OBOL:automatic + + + + + + + + + + + + + + + An acellular membrane that is part of the epithelium, lies adjacent to the epithelial cells, and is the fusion of the the basal lamina and the reticular lamina. + this class represents a continuous sheet of basement membrane which can underlie multiple epithelial cells over large regions. In contrast, the GO class 'basal membrane' represents a portion of substance on the scale of a single cell. + + + + + AAO:0010596 + FMA:63872 + GAID:915 + NCIT:C13191 + UMLS:C0004799 + basement membrane of connective tissue + membrana basalis + uberon + basement membrane + UBERON:0005769 + basement membrane of epithelium + + + + + + FMA + + + + + An acellular membrane that is part of the epithelium, lies adjacent to the epithelial cells, and is the fusion of the the basal lamina and the reticular lamina. + + + + + + + + + + + + + UMLS:C0004799 + ncithesaurus:Basement_Membrane + + + + + basement membrane of connective tissue + FMA:63872 + + + + + membrana basalis + + + + + + + basement membrane + FMA:63872 + + + + + + + + + + A delimited region of dense mesenchyme within looser mesenchyme. + AEO:0000148 + EHDAA2_RETIRED:0003148 + EHDAA:8979 + mesenchyme condensation + uberon + UBERON:0005856 + developing mesenchymal condensation + + + + + + AEO + + + + + + cjm + + + + + A delimited region of dense mesenchyme within looser mesenchyme. + AEO:0000148 + + + + + mesenchyme condensation + EMAPA:25351 + + + + + + + + + + + + + + + + + + + + + + the paired ventral prominences formed by bifurcation of the first pharyngeal arches in the embryo; the two prominences unite ventrally and fuse to form the mandible and lower lip + check develops_from + + + EHDAA2:0001061 + EHDAA:5871 + EMAPA:17355 + FMA:293051 + NCIT:C34204 + UMLS:C1512982 + uberon + mandibular process + mandibular swelling + prominentia mandibularis + UBERON:0005867 + + mandibular prominence + + + + + the paired ventral prominences formed by bifurcation of the first pharyngeal arches in the embryo; the two prominences unite ventrally and fuse to form the mandible and lower lip + ISBN:0-683-40008-8 + MP:0010939 + + + + + UMLS:C1512982 + ncithesaurus:Mandibular_Prominence + + + + + mandibular process + + + + + + mandibular swelling + + + + + + prominentia mandibularis + + + + + + + + + + + + + + + + + + + + + + + + Organ with organ cavity, which has as parts a serous membrane and a serous cavity . Examples: pleural sac, pericardial sac, tendon sheath, bursa.[FMA] + + + EMAPA:16060 + FMA:9689 + MA:0000005 + uberon + UBERON:0005906 + See notes for serous membrane + serous sac + + + + + Organ with organ cavity, which has as parts a serous membrane and a serous cavity . Examples: pleural sac, pericardial sac, tendon sheath, bursa.[FMA] + + FMA:9689 + + + + + + + + + + + + + + + + + + + + + Epithelium that derives from the endoderm. Examples: urothelium, transitional epithelium of ureter, epithelium of prostatic gland.[FMA] + FMA:69065 + endoderm-derived epithelium + endoepithelium + uberon + UBERON:0005911 + endo-epithelium + + + + + Epithelium that derives from the endoderm. Examples: urothelium, transitional epithelium of ureter, epithelium of prostatic gland.[FMA] + FMA:69065 + + + + + + + + + + + + + + + + + + + + + + + + + + + + Subdivision of skeleton which consists of cranial skeleton, set of all vertebrae, set of all ribs and sternum[FMA, modified]. + Skeletal subdivision of the central body axis including the cranium, vertebrae, notochord, ribs, and sternum.[VSAO] + + + + + AAO:0000963 + EMAPA:17214 + EMAPA:18043 + MA:0000308 + NCIT:C32172 + UMLS:C0222645 + VSAO:0000056 + XAO:0004011 + uberon + skeleton axiale + UBERON:0005944 + + + axial skeleton plus cranial skeleton + http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton + http://upload.wikimedia.org/wikipedia/commons/8/8b/Axial_skeleton_diagram.svg + + + + + Subdivision of skeleton which consists of cranial skeleton, set of all vertebrae, set of all ribs and sternum[FMA, modified]. + + + + FMA:71221 + VSAO:0000056 + + + + + Skeletal subdivision of the central body axis including the cranium, vertebrae, notochord, ribs, and sternum.[VSAO] + 2012-08-14 + VSAO:0000056 + VSAO + PSPUB:0000170 + + + + + UMLS:C0222645 + ncithesaurus:Axial_Skeleton + + + + + skeleton axiale + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The laminar structure of the heart + uberon + UBERON:0005983 + + + heart layer + + + + + The laminar structure of the heart + MP:0010545 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation + TODO - change relation from part_of + + MESH:D003331 + uberon + UBERON:0005985 + + coronary vessel + + + + + Any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation + MP:0010551 + + + + + + + + + + + + + + + Anatomical structure embedded in or located in the integument that is part of the integumental system. Examples: hair, follicles, skin glands, claws, nails, feathers. + add subclasses based on resolution of CARO tracker item. Also check: adnexal gland. Note that MP implicitly includes hypodermis. + the tissue or structures associated with or embedded in the skin such as hair and hair follicles, sweat glands, sebaceous glands and claws or nails[MP:0010678] + + EMAPA:37883 + body hair or bristle + uberon + adnexae cutis + skin adnexa + skin adnexal structure + skin appendage + UBERON:0006003 + + integumentary adnexa + + + + + Anatomical structure embedded in or located in the integument that is part of the integumental system. Examples: hair, follicles, skin glands, claws, nails, feathers. + + + + + + + the tissue or structures associated with or embedded in the skin such as hair and hair follicles, sweat glands, sebaceous glands and claws or nails[MP:0010678] + MP:0010678 + + + + + EMAPA:37883 + MA:th + + + + + body hair or bristle + GO:GO + + + + + adnexae cutis + + + + + + + skin adnexa + + + + + + skin appendage + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + uberon + UBERON:0006056 + posterior surface of head + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The thin bilaminar membrane derived from the prechordal plate that is devoid of mesoderm and formed by the apposition of the stomodeal ectoderm with the foregut endoderm; after the embryonic head fold has evolved it lies at the caudal limit of the stomodeum, forming a septum between the primitive mouth and pharynx; the membrane eventually disappears, and thus a communication is established between the mouth and the future pharynx. + + + EHDAA2:0000189 + EHDAA:536 + EMAPA:16259 + FMA:313607 + VHOG:0000380 + uberon + oral membrane + oral plate + oropharyngeal membrane + pharyngeal membrane + UBERON:0006211 + + + buccopharyngeal membrane + http://upload.wikimedia.org/wikipedia/commons/9/93/Gray977.png + + + + + + + + + + + EHDAA2 + + + + + The thin bilaminar membrane derived from the prechordal plate that is devoid of mesoderm and formed by the apposition of the stomodeal ectoderm with the foregut endoderm; after the embryonic head fold has evolved it lies at the caudal limit of the stomodeum, forming a septum between the primitive mouth and pharynx; the membrane eventually disappears, and thus a communication is established between the mouth and the future pharynx. + MP:0012521 + + + + + oral membrane + MP:0012521 + + + + + oral plate + MP:0012521 + + + + + oropharyngeal membrane + + + + + + pharyngeal membrane + MP:0012521 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The foremost region of the future forebrain that develops into the diencephalon. + EFO:0003442 + EHDAA2:0000600 + EHDAA:844 + EMAPA:16514 + RETIRED_EHDAA2:0000386 + TAO:0000574 + ZFA:0000574 + presumptive diencephalon + uberon + UBERON:0006222 + + + + future diencephalon + + + + + + + + + + + EHDAA2 + + + + + The foremost region of the future forebrain that develops into the diencephalon. + + UBERON:cjm + + + + + presumptive diencephalon + TAO:0000574 + + + + + + + + + + + + + + + + + + + + + The embryonic precursor of the brain. + The embryonic precursor of the brain and the set of mature brain structures that derive from it (CUMBO) + BAMS:Enc + BTO:0004726 + EFO:0003431 + EHDAA:300 + EHDAA:830 + EMAPA:16089 + FMA:312967 + RETIRED_EHDAA2:0000591 + TAO:0000146 + ZFA:0000146 + brain rudiment + presumptive brain + encephalon + uberon + embryonic brain + UBERON:0006238 + + + + + future brain + + + + + The embryonic precursor of the brain. + NLX:94995 + + + + + The embryonic precursor of the brain and the set of mature brain structures that derive from it (CUMBO) + + + + + + brain rudiment + TAO:0000146 + + + + + presumptive brain + ZFA:0000146 + + + + + encephalon + NLX:94995 + + + + + embryonic brain + BTO:0004726 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A presumptive structure that has the potential to develop into a forebrain. + TODO. Add relationships to neural plate (both ZFA and EMAPA time this with the neural plate) + + BAMS:Pros + EFO:0003423 + EHDAA2:0000661 + EHDAA:2643 + EMAPA:16640 + TAO:0000062 + ZFA:0000062 + future prosencephalon + presumptive forebrain + presumptive prosencephalon + uberon + prosencephalon + UBERON:0006240 + + + + future forebrain + + + + + A presumptive structure that has the potential to develop into a forebrain. + OBOL:automatic + + + + + presumptive forebrain + ZFA:0000062 + + + + + presumptive prosencephalon + TAO:0000062 + + + + + prosencephalon + EHDAA2:0000661 + + + + + + + + + + + + + + + + + + + + + + + + + + + EFO:0003438 + EHDAA2:0000674 + EHDAA:898 + EMAPA:16092 + EMAPA:16755 + TAO:0000417 + ZFA:0000417 + presumptive spinal cord + presumptive spinal cord neural keel + presumptive spinal cord neural plate + presumptive spinal cord neural rod + uberon + UBERON:0006241 + + + future spinal cord + + + + + + + + + + + EHDAA2 + + + + + presumptive spinal cord + ZFA:0000417 + + + + + presumptive spinal cord neural keel + TAO:0000417 + + + + + presumptive spinal cord neural plate + TAO:0000417 + + + + + presumptive spinal cord neural rod + TAO:0000417 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical junctions that overlaps the mouth and foregut. + EHDAA:534 + EMAPA:16258 + RETIRED_EHDAA2:0001205 + VHOG:0000592 + uberon + UBERON:0006264 + + mouth-foregut junction + + + + + An anatomical junctions that overlaps the mouth and foregut. + OBOL:automatic + + + + + + + + + + + + + + + + + + The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord. + TODO - check ordering; awaiting confirmation from JB + The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord. [Carson_JL, Dehart_DB, Developmental_Dynamics_(1994)_201:_260-278, Gesteland_K_and_Schoenwolf_GC, Inagaki_T, Morphogenesis_of_the_murine_node_and_notochordal_plate, The_prechordal_plate, Vrablic_T, see_Mueller_F_and_O'Rahilly_R, the_rostral_end_of_the_notochord_and_nearby_median_features_in_staged_human_embryos._Cells_Tissues_Organs_(2003)_173:_1-20_and_Sulik_K][VHOG] + + EHDAA2:0001278 + EHDAA:264 + EMAPA:16101 + NCIT:C34231 + UMLS:C1518429 + VHOG:0001212 + uberon + UBERON:0006267 + + notochordal plate + + + + + + EHDAA2 + + + + + + + + + + + EHDAA2 + + + + + The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord. + VHOG:0001212 + + + + + The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord. [Carson_JL, Dehart_DB, Developmental_Dynamics_(1994)_201:_260-278, Gesteland_K_and_Schoenwolf_GC, Inagaki_T, Morphogenesis_of_the_murine_node_and_notochordal_plate, The_prechordal_plate, Vrablic_T, see_Mueller_F_and_O'Rahilly_R, the_rostral_end_of_the_notochord_and_nearby_median_features_in_staged_human_embryos._Cells_Tissues_Organs_(2003)_173:_1-20_and_Sulik_K][VHOG] + 2012-09-17 + VHOG:0001212 + VHOG + + + + + + UMLS:C1518429 + ncithesaurus:Notochordal_Plate + + + + + + + + + + + + + + + + A midline cellular cord formed from the migration of mesenchymal cells from the primitive knot + + EHDAA2:0001279 + EHDAA:224 + EMAPA:16102 + FMA:293135 + NCIT:C34232 + UMLS:C1518430 + VHOG:0001213 + uberon + chordamesoderm + presumptive notochord + UBERON:0006268 + + The notochordal process grows cranially until it reaches the prechordal plate, the future site of the mouth. In this area the ectoderm is attached directly to the endoderm without intervening mesoderm. This area is known as the oropharyngeal membrane, and it will break down to become the mouth. At the other end of the primitive streak the ectoderm is also fused directly to the endoderm; this is known as the cloacal membrane (proctodeum), or primordial anus. + notochordal process + + + + + + + + + + + EHDAA2 + + + + + A midline cellular cord formed from the migration of mesenchymal cells from the primitive knot + + + + + + UMLS:C1518430 + ncithesaurus:Notochordal_Process + + + + + + + + + + + + + + + + + + + + + + + + + + + Multi-tissue structure that is part of the heart tube and will become the cardiac ventricle. + UBERON:0010226 + embryonic ventricle + + + EHDAA2:0001531 + EMAPA:16350 + FMA:71006 + NCIT:C34160 + TAO:0002231 + ZFA:0001719 + early heart ventricle + embryonic heart ventricle + future heart ventricle + presumptive cardiac ventricle heart tube + primitive ventricle + primitive ventricle of heart + primordial cardiac ventricle + primordial ventricle + uberon + UBERON:0006283 + The embryonic ventricle or primitive ventricle of the developing heart gives rise to the trabeculated parts of the left and right ventricles. In contrast, the smooth parts of the left and right ventricles originate from the embryological bulbus cordis. The primitive ventricle becomes divided by a septum, the septum inferius or ventricular septum, which grows upward from the lower part of the ventricle, its position being indicated on the surface of the heart by a furrow. Its dorsal part increases more rapidly than its ventral portion, and fuses with the dorsal part of the septum intermedium. For a time an interventricular foramen exists above its ventral portion, but this foramen is ultimately closed by the fusion of the aortic septum with the ventricular septum[WP] + future cardiac ventricle + + + + + + + + + + + ZFA + + + + + + + + + + + EMAPA + + + + + Multi-tissue structure that is part of the heart tube and will become the cardiac ventricle. + ZFA:0001719 + + + + + presumptive cardiac ventricle heart tube + ZFA:0001719 + + + + + primitive ventricle + EHDAA2:0001531 + + + + + primitive ventricle of heart + EMAPA:16350 + + + + + primordial cardiac ventricle + FMA:71006 + + + + + primordial ventricle + FMA:71006 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A segment of the eyeball that is filled with refractive media + + + BTO:0002085 + EMAPA:37529 + FMA:58071 + MA:0002459 + NCIT:C32301 + UMLS:C0459556 + eye chamber + eyeball chamber + uberon + chamber of eye + UBERON:0006311 + chamber of eyeball + + + + + A segment of the eyeball that is filled with refractive media + + + + + + EMAPA:37529 + MA:th + + + + + UMLS:C0459556 + ncithesaurus:Chamber_of_the_Eye + + + + + eye chamber + MA:0002459 + + + + + eyeball chamber + FMA:58071 + + + + + chamber of eye + BTO:0002085 + + + + + + + + + + + + + + + + Body substance in a liquid or semi-solid state in the eyeball which serves to refract light. + ocular refraction + MA:0001911 + uberon + UBERON:0006312 + ocular refractive media + + + + + Body substance in a liquid or semi-solid state in the eyeball which serves to refract light. + + + + + + + + + + Liquid components of living organisms. includes fluids that are excreted or secreted from the body as well as body water that normally is not. + fluid + + BIRNLEX:20 + EMAPA:37441 + FMA:280556 + GAID:266 + MESH:D001826 + galen:BodyFluid + body fluid + uberon + UBERON:0006314 + + bodily fluid + + + + + Liquid components of living organisms. includes fluids that are excreted or secreted from the body as well as body water that normally is not. + + MESH:A12.207 + + + + + EMAPA:37441 + MA:th + + + + + body fluid + GAID:266 + + + + + + + + + + + + + + + + + + + + + + + + + + A nucleus of brain that is part of a brainstem. + EMAPA:32790 + MA:0000821 + uberon + brain stem nucleus + UBERON:0006331 + brainstem nucleus + + + + + A nucleus of brain that is part of a brainstem. + OBOL:automatic + + + + + brain stem nucleus + EMAPA:32790 + + + + + + + + + + + + + + + + 2 + + + + + 2 + + + + + + + + + + + + + + + An artery that connects two larger arteries. + + EMAPA:18598 + MA:0001938 + NCIT:C52851 + UMLS:C1707451 + uberon + UBERON:0006347 + Grouping for anterior and posterior + communicating artery + + + + + An artery that connects two larger arteries. + ncithesaurus:Communicating_Artery + + + + + UMLS:C1707451 + ncithesaurus:Communicating_Artery + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of organism substance that secreted_by a zone of skin. + MA:0002537 + skin fluid/secretion + uberon + skin fluid + skin substance + UBERON:0006535 + skin secretion + + + + + A portion of organism substance that secreted_by a zone of skin. + OBOL:automatic + + + + + skin fluid/secretion + MA:0002537 + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of organism substance that secreted_by a respiratory system. + + EMAPA:36550 + MA:0002533 + NCIT:C13722 + UMLS:C1514899 + uberon + respiratory system fluid + respiratory system secretion + UBERON:0006538 + respiratory system fluid/secretion + + + + + A portion of organism substance that secreted_by a respiratory system. + OBOL:automatic + + + + + UMLS:C1514899 + ncithesaurus:Respiratory_System_Fluid_or_Secretion + + + + + + + + + The pharynx is the part of the digestive system immediately posterior to the mouth[GO]. + currently this is an extremely generic class, encompassing both protostomes and deuterostomes. + branchial + pharyngeal + FBbt:00005380 + MAT:0000049 + MIAA:0000049 + uberon + anterior part of foregut + pharyngeal tube + UBERON:0006562 + + + pharynx + + + + + The pharynx is the part of the digestive system immediately posterior to the mouth[GO]. + GO:0060465 + + + + + + + + + + + + + + + + + + + + + + + + + + A nucleus of brain that is part of a diencephalon. + TAO:0002191 + ZFA:0001659 + uberon + UBERON:0006569 + diencephalic nucleus + + + + + A nucleus of brain that is part of a diencephalon. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Presumptive structure of the blastula that will develop into endoderm. + AAO:0000471 + EFO:0003437 + TAO:0000416 + ZFA:0000416 + uberon + UBERON:0006595 + + presumptive endoderm + + + + + Presumptive structure of the blastula that will develop into endoderm. + + + + + + + + + + + + + + + + + + + + + + + + + + + AAO:0000468 + EFO:0003439 + TAO:0000568 + ZFA:0000568 + future blood + uberon + UBERON:0006596 + + presumptive blood + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Portion of embryonic tissue determined by fate mapping to become a structure. + Consider merging with anlage + AAO:0000479 + TAO:0001116 + ZFA:0001116 + future structure + presumptive structures + uberon + UBERON:0006598 + presumptive structure + + + + + Portion of embryonic tissue determined by fate mapping to become a structure. + GOC:CVS + GOC:YMB + ZFA:0001116 + + + + + presumptive structures + ZFA:0001116 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Presumptive structure of the blastula that will develop into ectoderm. + AAO:0000470 + EFO:0003466 + TAO:0001376 + XAO:0004132 + ZFA:0001376 + uberon + presumptive epidermis + UBERON:0006601 + + presumptive ectoderm + + + + + Presumptive structure of the blastula that will develop into ectoderm. + + + + + + presumptive epidermis + ZFA:0001376 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Presumptive structure of the blastula that will develop into mesoderm. + AAO:0000476 + EFO:0003467 + TAO:0001377 + ZFA:0001377 + uberon + UBERON:0006603 + + presumptive mesoderm + + + + + Presumptive structure of the blastula that will develop into mesoderm. + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical boundary that adjacent_to a epithelium. + FMA:70997 + epithelium surface + uberon + UBERON:0006677 + surface of epithelium + + + + + An anatomical boundary that adjacent_to a epithelium. + OBOL:automatic + + + + + epithelium surface + FMA:70997 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + the edge of the cornea where it joins the sclera; the limbus is a common site for the occurrence of corneal epithelial neoplasm + + + EFO:0001403 + EMAPA:37835 + FMA:58342 + GAID:896 + MESH:D016850 + ZFA:0005570 + cornea limbus + corneal limbus + corneal-scleral limbus + corneoscleral junction + limbus corneae + sclerocorneal junction + sclerocorneal limbus + uberon + limbus corneae + UBERON:0006761 + + + + This location has parts such as blood vessels etc. See PMC2868485, http://www.ncbi.nlm.nih.gov/pubmed/2695343 + corneo-scleral junction + http://upload.wikimedia.org/wikipedia/commons/3/3d/Limbus.png + + + + + the edge of the cornea where it joins the sclera; the limbus is a common site for the occurrence of corneal epithelial neoplasm + MP:0013477 + + + + + EMAPA:37835 + MA:th + + + + + corneal limbus + FMA:58342 + + + + + corneal limbus + GAID:896 + + + + + corneal-scleral limbus + + + + + + corneoscleral junction + GAID:896 + + + + + limbus corneae + + + + + + + sclerocorneal junction + FMA:58342 + + + + + sclerocorneal limbus + GAID:896 + + + + + limbus corneae + + + + + + + + + + + + + + + + + + + + + + + Loose connective tissue located at the outer and inner layers of organs. Examples: submucosal connective tissue, tunica adventitia of artery, papillary dermis, superficial fascia of dorsum of hand. + Also known as loose connective tissue. A pliable, mesh-like tissue with a fluid matrix that functions to cushion and protect body organs.[AAO] + relationship loss: subclass connective tissue proper (AAO:0000099)[AAO] + cushions body organs + + AAO:0000027 + FMA:63897 + loose areolar connective tissue + uberon + areolar tissue + loose connective tissue + UBERON:0006815 + areolar connective tissue + + + + + + FMA + + + + + Loose connective tissue located at the outer and inner layers of organs. Examples: submucosal connective tissue, tunica adventitia of artery, papillary dermis, superficial fascia of dorsum of hand. + FMA:63897 + + + + + Also known as loose connective tissue. A pliable, mesh-like tissue with a fluid matrix that functions to cushion and protect body organs.[AAO] + 2012-06-20 + AAO:0000027 + AAO + AAO:LAP + + + + + relationship loss: subclass connective tissue proper (AAO:0000099)[AAO] + 2012-06-20 + AAO:0000027 + AAO + + + + + cushions body organs + AAO + + + + + loose areolar connective tissue + FMA:63897 + + + + + loose connective tissue + AAO:0000027 + + + + + + + + + + + + + + + + + + + + + + + + + + A vasculature that is part of a organ. + FMA:74612 + organ vasculature + set of blood vessels of organ + uberon + UBERON:0006876 + + vasculature of organ + + + + + A vasculature that is part of a organ. + OBOL:automatic + + + + + organ vasculature + FMA:74612 + + + + + set of blood vessels of organ + FMA:74612 + + + + + + + + + + + + + + + + + + + + + + + + + + + A head mesenchyme that develops_from a mesoderm. + merged in 'head mesoderm' from XAO/AAO and EFO here. Partially implements https://github.com/obophenotype/uberon/wiki/The-neural-crest NC meeting scheme + AAO:0011051 + EFO:0003337 + EFO:0003603 + EHDAA2:0001118 + EHDAA:655 + EMAPA:16099 + EMAPA_RETIRED:16270 + FMA:293859 + TAO:0000998 + VHOG:0000185 + XAO:0000053 + ZFA:0000998 + head mesenchyme derived from mesoderm + head mesenchyme from head mesoderm + head mesenchyme from mesoderm + mesenchyme derived from head mesoderm + mesenchyme from head mesoderm + uberon + cranial mesoderm + head mesoderm + UBERON:0006904 + + + head mesenchyme from mesoderm + + + + + + ZFA + + + + + + + + + + + EHDAA2 + XAO + + + + + A head mesenchyme that develops_from a mesoderm. + OBOL:automatic + + + + + head mesenchyme from head mesoderm + EHDAA2:0001118 + + + + + mesenchyme derived from head mesoderm + EHDAA:1057 + + + + + cranial mesoderm + UBERON:0005280 + + + + + head mesoderm + AAO:0011051 + UBERON:0005280 + + + + + + + + + + + + + + + + + + + + + + + + + + + Mesenchyme that is part of a mandibular prominence. + EHDAA2:0001062 + EHDAA:5861 + EHDAA:5873 + EMAPA:17357 + mesenchyme of mandibular process + mesenchyme of mandibular prominence + uberon + UBERON:0006905 + mandibular process mesenchyme + + + + + Mesenchyme that is part of a mandibular prominence. + OBOL:automatic + + + + + mesenchyme of mandibular process + EMAPA:17357 + + + + + mesenchyme of mandibular prominence + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical space that surrounded_by a digestive tract. + BTO:0000349 + EMAPA:32908 + FMA:45677 + digestive tract lumen + gut cavity + gut lumen + lumen of alimentary tract + lumen of digestive tract + lumen of gut + uberon + UBERON:0006909 + lumen of digestive tract + + + + + An anatomical space that surrounded_by a digestive tract. + OBOL:automatic + + + + + digestive tract lumen + + + + + + gut cavity + BTO:0000349 + + + + + gut lumen + FMA:45677 + + + + + lumen of alimentary tract + + + + + + lumen of digestive tract + + + + + + lumen of gut + FMA:45677 + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of a lip. + The thick, high squamous-stratified epithelium that covers the lips. It contains abundant melanocytes, many mucous cells and has well differentiated taste buds.[TAO] + BTO:0004468 + TAO:0005334 + ZFA:0005334 + uberon + UBERON:0006913 + lip epithelium + + + + + An epithelium that is part of a lip. + OBOL:automatic + + + + + The thick, high squamous-stratified epithelium that covers the lips. It contains abundant melanocytes, many mucous cells and has well differentiated taste buds.[TAO] + 2012-08-14 + TAO:0005334 + TAO + ZFIN:ZDB-PUB-060921-12 + + + + + + + + + An epithelium characterised by its most superficial layer consisting of squamous epithelial cells. + FBbt:00007028 (squamous epithelium) A type of epithelium that is made up of flattened cells which are arranged with their long axes in the plane of the epithelium + + + + BTO:0002072 + NCIT:C12848 + UMLS:C0221909 + uberon + UBERON:0006914 + squamous epithelium + + + + + An epithelium characterised by its most superficial layer consisting of squamous epithelial cells. + + + + + + FBbt:00007028 (squamous epithelium) A type of epithelium that is made up of flattened cells which are arranged with their long axes in the plane of the epithelium + FBbt + + + + + UMLS:C0221909 + ncithesaurus:Squamous_Epithelium + + + + + + + + + + + + + + + The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis[GO]. The vascular cord is composed of angioblast or vascular endothelial cells in a solid linear mass called a cord. The cord then undergoes tubulogenesis to form the lumen of the vessels[ZFA]. + EFO:0003709 + TAO:0005077 + ZFA:0005077 + uberon + UBERON:0006965 + + vascular cord + + + + + The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis[GO]. The vascular cord is composed of angioblast or vascular endothelial cells in a solid linear mass called a cord. The cord then undergoes tubulogenesis to form the lumen of the vessels[ZFA]. + GO:0072360 + ZFA:0005077 + + + + + + + + + + + + + + + + + + + + + A capillary that is part of the coronary system. + ZFA:0005813 + heart capillary + uberon + UBERON:0006966 + coronary capillary + + + + + A capillary that is part of the coronary system. + + + + + + heart capillary + GO:0003248 + + + + + + + + + A two dimensional anatomical structure that is the boundary between an anatomical structure and an anatomical substance, an anatomical space or the organism's environment. Examples include the surface of your skin, the surface of the lining of your gut; the surface of the endothelium of you aorta that is in contact with blood.n + + BILA:0000010 + CARO:0001002 + EHDAA2_RETIRED:0003192 + FMA:24137 + NCIT:C34022 + UMLS:C1515977 + uberon + UBERON:0006984 + + Old definition: 'Non-material anatomical entity of two dimensions, that is demarcated by anatomical lines or points on the external or internal surfaces of anatomical structures.' Note, in the new definition, the space referred to is not necessarily an anatomical space. It may be the outside of an organism. + anatomical surface + + + + + + via morphological boundary in CARO + + + + + A two dimensional anatomical structure that is the boundary between an anatomical structure and an anatomical substance, an anatomical space or the organism's environment. Examples include the surface of your skin, the surface of the lining of your gut; the surface of the endothelium of you aorta that is in contact with blood.n + CARO:0001002 + + + + + UMLS:C1515977 + ncithesaurus:Anatomic_Surface + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The splanchnic mesoderm in the cardiogenic region where the heart develops; it gives rise to endocardial heart tubes that fuse to form the primordial cardiac tube, the heart primordium[web]. Two migratory heart primordia that move ventrally during the course of neurulation, and then fuse[XAO]. + consider FBbt:00005541 ! cardiogenic mesoderm + review EHDAA2 placement + + AAO:0011021 + BILA:0000051 + EFO:0000315 + EHDAA2:0000214 + EHDAA:385 + FMA:293143 + VHOG:0001641 + XAO:0000235 + cardiogenic splanchnopleure + uberon + cardiac mesoderm + cardiogenic mesoderm + cardiogenic region + heart primordia + UBERON:0007005 + + + cardiogenic splanchnic mesoderm + + + + + The splanchnic mesoderm in the cardiogenic region where the heart develops; it gives rise to endocardial heart tubes that fuse to form the primordial cardiac tube, the heart primordium[web]. Two migratory heart primordia that move ventrally during the course of neurulation, and then fuse[XAO]. + + + XAO:0000235 + + + + + cardiogenic splanchnopleure + EHDAA2:0000214 + + + + + cardiac mesoderm + XAO:0000235 + + + + + cardiogenic mesoderm + + + + + + cardiogenic region + + + + + + heart primordia + XAO:0000235 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Organism at the cleavage stage. + BILA:0000058 + uberon + UBERON:0007010 + cleaving embryo + + + + + Organism at the cleavage stage. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The endodermal cells generate only the lining of the digestive tube and its glands; mesodermal mesenchyme cells will surround this tube to provide the muscles for peristalsis + + + BILA:0000084 + NCIT:C34268 + UMLS:C1514442 + future digestive tract + future digestive tube + future gut + primitive gut + uberon + embryonic digestive tube + primordial digestive tube + primordial gut + UBERON:0007026 + presumptive gut + + + + + The endodermal cells generate only the lining of the digestive tube and its glands; mesodermal mesenchyme cells will surround this tube to provide the muscles for peristalsis + NCBIBook:NBK10107 + + + + + UMLS:C1514442 + ncithesaurus:Primordial_Gut + + + + + + + + + + + + + + + Cranial neural crest that migrates into the mandibular arch. + TAO:0007064 + XAO:0000024 + ZFA:0007064 + uberon + UBERON:0007098 + mandibular neural crest + + + + + + ZFA + + + + + + + + + + + ZFA + + + + + Cranial neural crest that migrates into the mandibular arch. + ZFA:0007064 + + + + + + + + + A hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood or analogs[GO,modified]. + note we reserve the subclass 'heart' from the vertebrate multi-chambered heart. 'The first heart-like organ is believed to have appeared 500my ago in an ancestral bilaterian'. Amniotes: four-chambered heart. Amphibians: two atria, one ventricle, pulmonary; fish: single atrium and ventricle; amphioxus: tubular, non-striated, closed, unidirectional; ascidians: tubular, striated, open, bidirectional; arthropods: tubular, open; C elegans: contractile pharynx; Cnideria: striated muscle cells associated with gastrodermis + + FBbt:00003154 + SPD:0000130 + TADS:0000147 + dorsal tube + heart + uberon + adult heart + UBERON:0007100 + + Gene notes: Bmp, Nkx, Gata + primary circulatory organ + + + + + A hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood or analogs[GO,modified]. + GO:0007507 + + + + + dorsal tube + + + + + + heart + GO:0007507 + + + + + adult heart + FBbt:00003154 + + + + + + + + + + + + + + + An intermediate stage (between the neural plate and neural rod) during the early segmentation period in the morphogenesis of the central nervous system primordium; the keel is roughly triangular shaped in cross section. + An intermediate stage (between the neural plate and neural rod) during the early segmentation period in the morphogenesis of the central nervous system primordium; the keel is roughly triangular shaped in cross section. Kimmel et al, 1995.[TAO] + EFO:0003497 + TAO:0000131 + ZFA:0000131 + uberon + presumptive central nervous system + UBERON:0007135 + + neural keel + + + + + An intermediate stage (between the neural plate and neural rod) during the early segmentation period in the morphogenesis of the central nervous system primordium; the keel is roughly triangular shaped in cross section. + ZFIN:ZDB-PUB-961014-576 + + + + + An intermediate stage (between the neural plate and neural rod) during the early segmentation period in the morphogenesis of the central nervous system primordium; the keel is roughly triangular shaped in cross section. Kimmel et al, 1995.[TAO] + 2012-08-14 + TAO:0000131 + TAO + ZFIN:curator + + + + + presumptive central nervous system + ZFA:0000131 + + + + + + + + + + + + + + + + + + + + + + + + + + A mesothelium that is part of a serous pericardium. + + BTO:0003157 + EMAPA:16133 + FMA:18149 + mesothelium of pericardium + pericardial mesothelium + serous pericardium mesothelium + uberon + UBERON:0007188 + mesothelium of serous pericardium + + + + + A mesothelium that is part of a serous pericardium. + OBOL:automatic + + + + + mesothelium of pericardium + FMA:18149 + + + + + pericardial mesothelium + FMA:18149 + + + + + serous pericardium mesothelium + FMA:18149 + + + + + + + + + + + + + + + + + + + + + + + + + + + Mesenchyme that develops_from a cranial neural crest. + EFO:0003572 + EHDAA2:0000735 + EMAPA:16169 + EMAPA:16271 + EMAPA_RETIRED:16271 + TAO:0000787 + ZFA:0000787 + head mesenchyme from cranial neural crest + head mesenchyme from neural crest + head neural crest derived mesenchyme + uberon + UBERON:0007213 + + + mesenchyme derived from head neural crest + + + + + + ZFA + + + + + Mesenchyme that develops_from a cranial neural crest. + OBOL:automatic + + + + + head mesenchyme from neural crest + EHDAA2:0000735 + + + + + + + + + + + + + + + + relationship to Meckel's cartilage to be added + Subsequent vertebrate evolution has also involved major alterations to the pharynx; perhaps the most notable occurred with the evolution of the gnathostomes. This involved substantial modifications to the most anterior pharyngeal segments, with the jaw forming from the first, anterior, pharyngeal segment, while the second formed its supporting apparatus, the hyoid.[well established][VHOG] + EHDAA2:0000031 + EHDAA:583 + EMAPA:16382 + VHOG:0000510 + ventral pharyngeal arch 1 + uberon + ventral mandibular arch + ventral visceral arch 1 + UBERON:0007237 + 1st arch mandibular component + + + + + + + + + + + EHDAA2 + + + + + Subsequent vertebrate evolution has also involved major alterations to the pharynx; perhaps the most notable occurred with the evolution of the gnathostomes. This involved substantial modifications to the most anterior pharyngeal segments, with the jaw forming from the first, anterior, pharyngeal segment, while the second formed its supporting apparatus, the hyoid.[well established][VHOG] + 2012-09-17 + VHOG:0000510 + VHOG + + DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) + + + + + ventral pharyngeal arch 1 + VHOG:0000510 + + + + + ventral mandibular arch + VHOG:0000510 + + + + + ventral visceral arch 1 + VHOG:0000510 + + + + + + + + + + + + + + + + + + + + + + + + + + A tunica media that is part of a artery. + + + EMAPA:36294 + EV:0100029 + FMA:14273 + NCIT:C49321 + UMLS:C1710627 + arterial media + tunica media (arteriae) + uberon + UBERON:0007239 + tunica media of artery + + + + + A tunica media that is part of a artery. + OBOL:automatic + + + + + UMLS:C1710627 + ncithesaurus:Venous_System_Smooth_Muscle_Tissue + + + + + arterial media + EV:0100029 + + + + + tunica media (arteriae) + FMA:14273 + + + + + + + + + + + + + + + + + + + + + + + + + + A tunica adventitia that is part of a artery. + + EMAPA:36295 + EV:0100030 + FMA:14274 + arterial adventitia + tunica externa (adventitia)(arteriae) + uberon + UBERON:0007240 + tunica adventitia of artery + + + + + A tunica adventitia that is part of a artery. + OBOL:automatic + + + + + arterial adventitia + EV:0100030 + + + + + tunica externa (adventitia)(arteriae) + FMA:14274 + + + + + + + + + + + + + + + + + + + + + + + + + + A tunica adventitia that is part of a vein. + + EMAPA:36310 + EV:0100034 + FMA:14355 + tunica externa (adventitia)(venae) + venous adventitia + uberon + UBERON:0007241 + tunica adventitia of vein + + + + + A tunica adventitia that is part of a vein. + OBOL:automatic + + + + + tunica externa (adventitia)(venae) + FMA:14355 + + + + + venous adventitia + EV:0100034 + + + + + + + + + + + + + + + + + + + + + + + + + + + A tunica intima that is part of a vein. + + EMAPA:36308 + EV:0100032 + FMA:14353 + tunica interna (intima)(venae) + venous intima + uberon + UBERON:0007242 + tunica intima of vein + + + + + A tunica intima that is part of a vein. + OBOL:automatic + + + + + tunica interna (intima)(venae) + FMA:14353 + + + + + venous intima + EV:0100032 + + + + + + + + + + + + + + + + + + + + + + + + + + A tunica media that is part of a vein. + + EMAPA:36309 + EV:0100033 + FMA:14354 + tunica media (venae) + venous media + uberon + UBERON:0007243 + tunica media of vein + + + + + A tunica media that is part of a vein. + OBOL:automatic + + + + + tunica media (venae) + FMA:14354 + + + + + venous media + EV:0100033 + + + + + + + + + + + + + + + + + + + + + + + + + + Gray matter of the central nervous system which is a collection of clustered nuclei. + FMA:256381 + FMA:84059 + uberon + cluster of neural nuclei + neural nuclei + nuclear complex + UBERON:0007245 + nuclear complex of neuraxis + + + + + Gray matter of the central nervous system which is a collection of clustered nuclei. + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The rhombencephalon (or hindbrain) is a developmental categorization of portions of the central nervous system in vertebrates. The rhombencephalon can be subdivided in a variable number of transversal swellings called rhombomeres. In the human embryo eight rhombomeres can be distinguished, from caudal to rostral: Rh7-Rh1 and the isthmus (the most rostral rhombomere). A rare disease of the rhombencephalon, 'rhombencephalosynapsis' is characterized by a missing vermis resulting in a fused cerebellum. Patients generally present with cerebellar ataxia. The caudal rhombencephalon has been generally considered as the initiation site for neural tube closure. + TODO - unify naming conventions + The embryonic rhombencephalon can be subdivided in a variable number of transversal swellings called rhombomeres. Rhombomeres Rh7-Rh4 form the myelencephalon that will give the medulla oblongata. Rhombomeres Rh3-Rh1 form the metencephalon that will form the pons and the cerebellum[NPX:PDR]. + + BAMS:HB + CALOHA:TS-2118 + EFO:0003440 + EHDAA2:0001630 + FMA:295640 + TAO:0000569 + ZFA:0000569 + presumptive rhombencephalon + uberon + embryonic rhombencephalon + future hindbrain + rhombencephalon + UBERON:0007277 + + presumptive hindbrain + + + + + + + + + + + XAO-abduced + + + + + + + + + + + cjm + + + + + The rhombencephalon (or hindbrain) is a developmental categorization of portions of the central nervous system in vertebrates. The rhombencephalon can be subdivided in a variable number of transversal swellings called rhombomeres. In the human embryo eight rhombomeres can be distinguished, from caudal to rostral: Rh7-Rh1 and the isthmus (the most rostral rhombomere). A rare disease of the rhombencephalon, 'rhombencephalosynapsis' is characterized by a missing vermis resulting in a fused cerebellum. Patients generally present with cerebellar ataxia. The caudal rhombencephalon has been generally considered as the initiation site for neural tube closure. + + + + + + The embryonic rhombencephalon can be subdivided in a variable number of transversal swellings called rhombomeres. Rhombomeres Rh7-Rh4 form the myelencephalon that will give the medulla oblongata. Rhombomeres Rh3-Rh1 form the metencephalon that will form the pons and the cerebellum[NPX:PDR]. + NPX:PDR + + + + + presumptive rhombencephalon + ZFA:0000569 + + + + + embryonic rhombencephalon + CALOHA:TS-2118 + + + + + future hindbrain + + + + + + rhombencephalon + EHDAA2:0001630 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A presumptive structure that has the potential to develop into a endocardium. + Portion of tissue that is part of the heart tube and will become the endocardium.[TAO] + TAO:0002233 + ZFA:0001724 + uberon + UBERON:0007280 + presumptive endocardium + + + + + A presumptive structure that has the potential to develop into a endocardium. + OBOL:automatic + + + + + Portion of tissue that is part of the heart tube and will become the endocardium.[TAO] + 2012-08-14 + TAO:0002233 + TAO + ZFIN:curator + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Embryonic structure that gives rise to the midbrain hindbrain boundary. + EFO:0003446 + TAO:0001187 + XAO:0004086 + ZFA:0001187 + presumptive MHB + presumptive midbrain-hindbrain boundary + uberon + UBERON:0007281 + + presumptive midbrain hindbrain boundary + + + + + + + + + + + ZFA + + + + + Embryonic structure that gives rise to the midbrain hindbrain boundary. + ZFA:0001187 + + + + + presumptive MHB + + + + + + presumptive midbrain-hindbrain boundary + ZFA:0001187 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A presumptive structure that has the potential to develop into a presomitic mesoderm. + EFO:0003421 + TAO:0000053 + ZFA:0000053 + uberon + presumptive segmental plates + UBERON:0007282 + + presumptive segmental plate + + + + + + + + + + + https://github.com/obophenotype/uberon/wiki/The-neural-crest + EDHAA2 + + + + + A presumptive structure that has the potential to develop into a presomitic mesoderm. + OBOL:automatic + + + + + presumptive segmental plates + ZFA:0000053 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A presumptive structure that has the potential to develop into a neural plate. + consider merging + Region of the gastrula which gives rise to the neural plate.[TAO] + EFO:0003424 + TAO:0000063 + ZFA:0000063 + prospective neuroectoderm + prospective vegetal ectoderm + uberon + UBERON:0007284 + + presumptive neural plate + + + + + A presumptive structure that has the potential to develop into a neural plate. + OBOL:automatic + + + + + Region of the gastrula which gives rise to the neural plate.[TAO] + 2012-08-14 + TAO:0000063 + TAO + ZFIN:curator + + + + + prospective neuroectoderm + ZFA:0000063 + + + + + prospective vegetal ectoderm + ZFA:0000063 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The part of the blastula that has the potential to develop into a paraxial mesoderm. + EFO:0003443 + TAO:0000591 + XAO:0004134 + ZFA:0000591 + future paraxial mesenchyme + future paraxial mesoderm + uberon + UBERON:0007285 + + presumptive paraxial mesoderm + + + + + + + + + + + + + + + + + + + + + + + + + The part of the blastula that has the potential to develop into a paraxial mesoderm. + + UBERON:cjm + + + + + future paraxial mesenchyme + UBERON:cjm + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A presumptive structure that has the potential to develop into a forebrain-midbrain boundary. + EFO:0003463 + TAO:0001368 + ZFA:0001368 + uberon + UBERON:0007288 + + presumptive forebrain midbrain boundary + + + + + A presumptive structure that has the potential to develop into a forebrain-midbrain boundary. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + A vasculature that is part of a chordate pharynx. + TAO:0005003 + ZFA:0005003 + branchial vasculature + uberon + UBERON:0007303 + pharyngeal vasculature + + + + + A vasculature that is part of a chordate pharynx. + OBOL:automatic + + + + + branchial vasculature + ZFA:0005003 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The epidermis is the entire outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species[GO]. + this grouping class exists primarily to align with GO - see GO:0008544. + + BSA:0000073 + BTO:0000313 + FBbt:00004993 + HAO:0000298 + TADS:0000109 + WBbt:0005733 + epidermis + epidermis (sensu Metazoa) + outer epidermal layer + outer epithelial layer + uberon + hypoderm + hypodermis + UBERON:0007376 + + outer epithelium + + + + + The epidermis is the entire outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species[GO]. + GO:0008544 + + + + + epidermis + GO:0008544 + + + + + hypoderm + BTO:0000313 + + + + + + hypodermis + GO:0008544 + WBbt:0005733 + + + + + + + + + + + + + + + + + + + + + + + + Outermost layer of cells surrounding the embryo. + Outermost monolayer of cells surrounding the embryo that become very flattened in the blastula and give rise to the periderm. Sometimes used synonymously with periderm. Kimmel et al, 1995.[TAO] + relationship loss: develops_from superficial blastomere (TAO:0001484)[TAO] + Originally this tissue is one cell layer thick but in most vertebrates it soon becomes a two layered structure. The outer layer gives rise to the periderm. + EFO:0003425 + TAO:0000086 + ZFA:0000086 + EVL + enveloping layer + uberon + UBERON:0007383 + + enveloping layer of ectoderm + + + + + Outermost layer of cells surrounding the embryo. + + + + + + Outermost monolayer of cells surrounding the embryo that become very flattened in the blastula and give rise to the periderm. Sometimes used synonymously with periderm. Kimmel et al, 1995.[TAO] + 2012-08-14 + TAO:0000086 + TAO + ZFIN:curator + + + + + relationship loss: develops_from superficial blastomere (TAO:0001484)[TAO] + 2012-08-14 + TAO:0000086 + TAO + + + + + EVL + ZFA:0000086 + + + + + enveloping layer + ZFIN:ZDB-PUB-961014-576 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A nucleus of brain that spans a midbrain tegmentum. + this class groups together any nuclei in the tegmentum region, possibly including disparate structures across species + UBERON:0012277 + FMA:258768 + ZFA:0005577 + tegmental nuclei + tegmental nucleus + uberon + UBERON:0007414 + nucleus of midbrain tegmentum + + + + + A nucleus of brain that spans a midbrain tegmentum. + OBOL:automatic + + + + + tegmental nuclei + + + + + + tegmental nucleus + ZFA:0005577 + + + + + + + + + An epithelial tube open at both ends that allows fluid flow. + AEO_RETIRED:0000116 + RETIRED_EHDAA2:0003116 + uberon + UBERON:0007500 + epithelial tube open at both ends + + + + + + AEO + + + + + An epithelial tube open at both ends that allows fluid flow. + AEO:JB + UBERONREF:0000001 + + + + + + + + + A closed epithelium with a lumen. + EHDAA2:0003119 + AEO:0000119 + EHDAA2:0003119 + uberon + UBERON:0007503 + epithelial vesicle + + + + + + AEO + + + + + A closed epithelium with a lumen. + AEO:JB + + + + + + + + + Mesenchyme with little extracellular matrix. + EHDAA2:0003146 + AEO:0000146 + EHDAA2:0003146 + uberon + UBERON:0007524 + dense mesenchyme tissue + + + + + + AEO + + + + + Mesenchyme with little extracellular matrix. + AEO:JB + + + + + + + + + Mesenchymal cells that are migrating. + this class will be an important part of the NC reorganization + EHDAA2:0003152 + AEO:0000152 + EHDAA2:0003152 + uberon + UBERON:0007530 + migrating mesenchyme population + + + + + Mesenchymal cells that are migrating. + AEO:JB + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A thin, loose vascular connective tissue that makes up the membranes surrounding joints and the sheaths protecting tendons (particularly flexor tendons in the hands and feet) where they pass over bony prominences. Synovial tissue contains synovial cells, which secrete a viscous liquid called synovial fluid; this liquid contains protein and hyaluronic acid and serves as a lubricant and nutrient for the joint cartilage surfaces[BTO]. Synovial tissue can be found in tendons (tissues that connect muscle to bone), bursae (fluid-filled, cushioning sacs found in spaces between tendons, ligaments, and bones), and the cavity (hollow enclosed area) that separates the bones of a freely movable joint, such as the knee or elbow[BTO]. + BTO:0001338 + CALOHA:TS-0998 + FMA:66762 + synovium + stratum synoviale + synovial layer + synovial membrane + uberon + synovial tissue + UBERON:0007616 + layer of synovial tissue + + + + + + + + + + + BTO + + + + + A thin, loose vascular connective tissue that makes up the membranes surrounding joints and the sheaths protecting tendons (particularly flexor tendons in the hands and feet) where they pass over bony prominences. Synovial tissue contains synovial cells, which secrete a viscous liquid called synovial fluid; this liquid contains protein and hyaluronic acid and serves as a lubricant and nutrient for the joint cartilage surfaces[BTO]. Synovial tissue can be found in tendons (tissues that connect muscle to bone), bursae (fluid-filled, cushioning sacs found in spaces between tendons, ligaments, and bones), and the cavity (hollow enclosed area) that separates the bones of a freely movable joint, such as the knee or elbow[BTO]. + + BTO:0001338 + + + + + synovium + CALOHA:TS-0998 + + + + + stratum synoviale + FMA:TA + + + + + synovial layer + FMA:66762 + + + + + synovial membrane + FMA:66762 + + + + + synovial tissue + BTO:0001338 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical cavity that surrounded_by a synovial joint. + FMA:11356 + articular cavity (synovial joint) + cavitas articularis (junctura synovialis) + cavity of synovial joint + uberon + joint cavity + synovial cavity + UBERON:0007617 + synovial cavity of joint + + + + + An anatomical cavity that surrounded_by a synovial joint. + OBOL:automatic + + + + + articular cavity (synovial joint) + FMA:11356 + + + + + cavitas articularis (junctura synovialis) + FMA:11356 + + + + + cavity of synovial joint + FMA:11356 + + + + + joint cavity + FMA:11356 + + + + + synovial cavity + FMA:11356 + + + + + + + + + + + + + + + + + + + + + + + + + + epithelial layer of the retina, ciliary body, or iris composed of cells containing pigment granules. + GAID:907 + MESH:D010857 + uberon + eye pigment epithelium + UBERON:0007625 + + pigment epithelium of eye + + + + + epithelial layer of the retina, ciliary body, or iris composed of cells containing pigment granules. + MP:0005200 + + + + + eye pigment epithelium + MESH:A09.371.670 + + + + + + + + + + + + + + + + + + + + + + + + + + + A neural nucleus that is part of a medulla oblongata. + + FMA:258772 + uberon + UBERON:0007635 + nucleus of medulla oblongata + + + + + A neural nucleus that is part of a medulla oblongata. + OBOL:automatic + + + + + + + + + + + + 2 + + + + An anatomical structure that connects two structures + junction + + FMA:5898 + anatomical junction + uberon + UBERON:0007651 + + anatomical junction + + + + + + FMA + + + + + An anatomical structure that connects two structures + + + + + + + + + + + Anlagen are populations of contiguous cells, typically arranged in one plane, that are morphologically indistinct, but that already correspond in extent to a later organ/tissue. + field + + AEO:0000170 + EFO:0001649 + EHDAA2:0003170 + FBbt:00005426 + developmental field + uberon + future organ + organ field + UBERON:0007688 + + anlage + + + + + + FBbt + + + + + + AEO + FBbt + + + + + Anlagen are populations of contiguous cells, typically arranged in one plane, that are morphologically indistinct, but that already correspond in extent to a later organ/tissue. + + FBbt:00005426 + JB:DEF + + + + + + + + + + + + + + + + . + EFO:0003626 + EHDAA2:0001457 + EHDAA:962 + EMAPA:32754 + FMA:293087 + TAO:0001104 + ZFA:0001104 + early pharyngeal arch endoderm + uberon + pharyngeal arch endoderm + pharyngeal endoderm + pharyngeal region endoderm + UBERON:0007690 + + relation conflict: ZFA vs EHDAA2. Note EHDAA2 term renamed to 'early PA endoderm' + early pharyngeal endoderm + + + + + + + + + + + cjm + + + + + . + + + + + + early pharyngeal arch endoderm + EHDAA2:0001457 + + + + + pharyngeal endoderm + ZFA:0001104 + + + + + pharyngeal region endoderm + EHDAA2:0001456 + + + + + + + + + + + + + + + + + + + + + + + + + + A gland that is part of a epidermis. + FMA:59153 + epidermal gland + gland of epidermis + uberon + UBERON:0007771 + + epidermis gland + + + + + A gland that is part of a epidermis. + OBOL:automatic + + + + + gland of epidermis + FMA:59153 + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any bodily fluid that has passed through a membrane such as the capillary wall, as a result of unbalanced hydrostatic and osmotic forces + transudative + characteristically low in protein and cellular content (unless there has been secondary concentration) + FMA:12276 + GAID:1195 + MESH:D005122 + ncithesaurus:Transudate + uberon + plasma ultrafiltrate + UBERON:0007779 + transudate + + + + + Any bodily fluid that has passed through a membrane such as the capillary wall, as a result of unbalanced hydrostatic and osmotic forces + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any fluid produced by a serous gland. + serous fluid + + serosal fluid + serous gland fluid + uberon + UBERON:0007794 + secretion of serous gland + + + + + Any fluid produced by a serous gland. + UBERON:cjm + + + + + serosal fluid + + + + + + + + + + + + + + + + Anatomical system that consists of all blood and lymph vessels. + consider merging with vasculature + The cardiovascular and lymphatic systems, collectively[ncithesaurus:Vascular_System]. + in both MA and BTO, the arterial system and venous sytem are subtypes of the vascular system + + BTO:0001085 + CALOHA:TS-2053 + EHDAA2:0004520 + EMAPA:35905 + MA:0002718 + NCIT:C33854 + UMLS:C0489903 + uberon + Gefaesssystem@de + UBERON:0007798 + + vascular system + + + + + + + + + + + MA + + + + + Anatomical system that consists of all blood and lymph vessels. + + + + + + The cardiovascular and lymphatic systems, collectively[ncithesaurus:Vascular_System]. + ncithesaurus:Vascular_System + + + + + in both MA and BTO, the arterial system and venous sytem are subtypes of the vascular system + MA + + + + + UMLS:C0489903 + ncithesaurus:Vascular_System + + + + + Gefaesssystem@de + BTO:0001085 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The anteriormost subdivision of the body that includes the head, jaws, pharyngeal region and the neck (if present). In vertebrates this is the subdivision that includes the cervical vertebrae. + + + CALOHA:TS-2356 + EV:0100009 + FMA:280881 + MA:0000006 + NCIT:C12418 + UMLS:C0460004 + WikipediaCategory:Head_and_neck + galen:HeadAndNeck + uberon + cephalic area + cephalic part of animal + cephalic region + head and neck + head or neck + UBERON:0007811 + + craniocervical region + + + + + + MA + + + + + The anteriormost subdivision of the body that includes the head, jaws, pharyngeal region and the neck (if present). In vertebrates this is the subdivision that includes the cervical vertebrae. + + + + + + UMLS:C0460004 + ncithesaurus:Head_and_Neck + + + + + cephalic area + + + + + + cephalic part of animal + + + + + + cephalic region + + + + + + head and neck + FMA:280881 + + + + + + + + + + + + + + + + + + + + + + + + + + Musculature system of the pharyngeal and head regions. + in MA this is restricted to skeletal muscles + EMAPA:37259 + MA:0000571 + TAO:0000328 + ZFA:0000328 + head or neck muscle + uberon + head muscles + head or neck muscle + UBERON:0008229 + craniocervical region musculature + + + + + + MA + + + + + + + + + + + MA + + + + + Musculature system of the pharyngeal and head regions. + ZFA:0000328 + ZFA:curator + + + + + in MA this is restricted to skeletal muscles + MA + + + + + EMAPA:37259 + MA:th + + + + + head or neck muscle + MA:0000571 + + + + + head muscles + ZFA:0000328 + + + + + head or neck muscle + MA:0000571 + + + + + + + + + + + + + + + + + + + + + + + + + + An endothelium that is part of a heart [Automatically generated definition]. + this class includes any endothelia that are part of the heart. This might include the endocardial epithelia, as well as endothelia of vessels that are considered strictly part of the heart (e.g. outflow tract). As a grouping class, this may lack utility, and pending review this class may be obsoleted. For annotation consider a more specific class. + BTO:0004293 + uberon + cardiac endothelium + UBERON:0008307 + heart endothelium + + + + + An endothelium that is part of a heart [Automatically generated definition]. + OBOL:automatic + + + + + cardiac endothelium + BTO:0004293 + + + + + + + + + + + + + + + + + + + + + + A transient embryonic complex that comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming, which may include (depending on species) the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear[GO,modified]. + Currently defined in a vertebrate specific manner. The arch system has origins in basal deuterostomes, consider generalizing + + EHDAA2:0000187 + FMA:293041 + NCIT:C34248 + UMLS:C1519038 + embryonic pharyngeal complex + pharyngeal apparatus + pharyngeal system + uberon + pharyngeal arch complex + pharyngeal arch region + pharyngeal arches and clefts + pharyngeal complex + UBERON:0008814 + pharyngeal arch system + + + + + A transient embryonic complex that comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming, which may include (depending on species) the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear[GO,modified]. + GO:0060037 + GOC:dph + + + + + UMLS:C1519038 + ncithesaurus:Pharyngeal_Apparatus + + + + + pharyngeal system + GO:0060037 + + + + + pharyngeal arch region + EHDAA2:0000187 + + + + + + + + + + + + + + + + + + + + + + + + + + A head that is part of a embryo. + CALOHA:TS-0246 + FBbt:00000155 + FMA:293011 + uberon + UBERON:0008816 + + embryonic head + + + + + A head that is part of a embryo. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A brain that develops_from a neural tube. + a reasoner should automatically classify all the vertebrate ontology brain classes here + vertebrate brain + uberon + UBERON:0008823 + neural tube derived brain + https://github.com/obophenotype/uberon/issues/338 + + + + + + ZFA + + + + + + + + + + + FMA + + + + + A brain that develops_from a neural tube. + + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + Subdivision of endoskeleton derived from pharyngeal arches + Anatomical cluster that is part of the cranium and consists of the jaws, hyoid and branchial arches.[TAO] + Anatomical cluster that is part of the cranium and consists of the jaws, hyoid, and branchial arches.[AAO] + The part of the skull derived from the embryonic pharyngeal arches. [Biology_Online][VHOG] + The skull of ancestral tetrapods has the three basic components that we have been considering: (1) chondrocranium, (2) splanchnocranium, and (3) dermatocranium (reference 1); Each part of the skull arises from a separate phylogenetic source. The most ancient part is the splanchnocranium (visceral cranium), which first arose to support pharyngeal slits in protochordates (reference 2).[well established][VHOG] + VSAO labels this term 'pharyngeal arch' (2012-06-01) - however, it clearly means pharyngeal arch skeleton. + many sources define this as the part of the endoskeletal that is from pharyngeal arches - this would make it part-disjoint from dermatocranium. However, there are many bones in AOs that have part-paths to both + + AAO:0010157 + TAO:0001216 + VHOG:0000315 + VSAO:0000149 + XAO:0003176 + ZFA:0001216 + pharyngeal endoskeleton + viscerocranium + uberon + branchial arch skeleton + gill arch skeleton + pharyngeal arch + pharyngeal arch skeleton + pharyngeal skeleton + visceral cranium + visceral skeletal system + visceral skeleton + UBERON:0008895 + splanchnocranium + http://upload.wikimedia.org/wikipedia/commons/7/77/Illu_facial_bones.jpg + + + + + + + + + + + + + + + + + + + + + + redundant + + Grays + + + + + Subdivision of endoskeleton derived from pharyngeal arches + + + ISBN:0073040584 + + + + + Anatomical cluster that is part of the cranium and consists of the jaws, hyoid and branchial arches.[TAO] + 2012-08-14 + TAO:0001216 + TAO + ZFIN:curator + + + + + Anatomical cluster that is part of the cranium and consists of the jaws, hyoid, and branchial arches.[AAO] + 2012-06-20 + AAO:0010157 + AAO + AAO:EJS + + + + + The part of the skull derived from the embryonic pharyngeal arches. [Biology_Online][VHOG] + 2012-09-17 + VHOG:0000315 + VHOG + + + + + + The skull of ancestral tetrapods has the three basic components that we have been considering: (1) chondrocranium, (2) splanchnocranium, and (3) dermatocranium (reference 1); Each part of the skull arises from a separate phylogenetic source. The most ancient part is the splanchnocranium (visceral cranium), which first arose to support pharyngeal slits in protochordates (reference 2).[well established][VHOG] + 2012-09-17 + VHOG:0000315 + VHOG + + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.242, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.235 + + + + + VSAO labels this term 'pharyngeal arch' (2012-06-01) - however, it clearly means pharyngeal arch skeleton. + VSAO + + + + + pharyngeal endoskeleton + + + + + + viscerocranium + + VHOG:0000315 + ZFA:0001216 + + + + + + pharyngeal arch + VSAO:0000149 + + + + + + pharyngeal arch skeleton + ZFA:0001216 + + + + + pharyngeal skeleton + ZFA:0001216 + + + + + visceral cranium + + + + + + visceral skeletal system + + + + + + visceral skeleton + UBERONREF:0000007 + + + + + + + + + + + + + + + + System pertaining to blood vessels in the brain. + UBERON:0005284 + + BTO:0003840 + EFO:0003491 + EMAPA:35186 + FMA:242007 + FMA:61935 + TAO:0000099 + ZFA:0000099 + brain vasculature + cerebrovascular system + intracerebral vasculature + uberon + UBERON:0008998 + + vasculature of brain + + + + + System pertaining to blood vessels in the brain. + BTO:0003840 + + + + + cerebrovascular system + BTO:0003840 + + + + + intracerebral vasculature + FMA:61935 + + + + + + + + + + + + + + + + + + + + + + + + + + A vein that is part of a craniocervical region. + + EHDAA2:0004542 + craniocervical vein + head and neck veins + vein of head and neck + uberon + UBERON:0009141 + craniocervical region vein + + + + + A vein that is part of a craniocervical region. + OBOL:automatic + + + + + head and neck veins + EHDAA2:0004542 + + + + + + + + + + + + + + + + + + + + + + + + + + + + Sum total of mesenchyme in the embryo. + consider adding new class (EMAPA:16097) for mesenchyme of embryo (some mesenchyme is extraembryonic - e.g. amnion mesoderm) + UBERON:0003313 + EHDAA2:0001113 + EHDAA:177 + EMAPA:16097 + uberon + UBERON:0009142 + entire embryonic mesenchyme + + + + + + + + + + + EHDAA2 + + + + + Sum total of mesenchyme in the embryo. + + + + + + + + + + + + + + + + + EMAPA:16549 + RETIRED_EHDAA2:0001454 + pharyngeal region + uberon + UBERON:0009145 + pharyngeal region of foregut + + + + + + + + + + + EHDAA2 + + + + + pharyngeal region + EMAPA:16549 + + + + + + + + + + + + + + + + + + + + + + + + + + An ectoderm that is part of a buccopharyngeal membrane. + EHDAA2:0000190 + EMAPA:16260 + uberon + UBERON:0009479 + + ectoderm of buccopharyngeal membrane + + + + + An ectoderm that is part of a buccopharyngeal membrane. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + An endoderm that is part of a buccopharyngeal membrane. + EHDAA2:0000191 + EMAPA:16261 + uberon + UBERON:0009480 + + endoderm of buccopharyngeal membrane + + + + + An endoderm that is part of a buccopharyngeal membrane. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of mesenchymal tissue associated with an individual pharyngeal arch. + this represents a part of the entire arch mesenchyme (UBERON:0010046), and is therefore a superclass of the individual arch mesenchyme classes. Alternate definition: primordial embryonic connective tissue associated with the branchial arches, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to facial and cranial nerve-associated structures. + EMAPA:32755 + FMA:295694 + branchial arch mesenchyme + pharyngeal arch mesenchyme + uberon + UBERON:0009494 + + pharyngeal arch mesenchymal region + + + + + + EHDAA2 + + + + + + + + + + + cjm + + + + + A portion of mesenchymal tissue associated with an individual pharyngeal arch. + + + + + + this represents a part of the entire arch mesenchyme (UBERON:0010046), and is therefore a superclass of the individual arch mesenchyme classes. Alternate definition: primordial embryonic connective tissue associated with the branchial arches, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to facial and cranial nerve-associated structures. + MP:0011262 + + + + + branchial arch mesenchyme + MP:0011262 + + + + + pharyngeal arch mesenchyme + + + + + + + + + + + + + + + + + FMA:25054 + region of trunk + trunk subdivision + uberon + UBERON:0009569 + + subdivision of trunk + + + + + region of trunk + FMA:25054 + + + + + trunk subdivision + FMA:25054 + + + + + + + + + + + + + + + + + + + + + + + + + + EHDAA2:0000397 + EMAPA:16906 + VHOG:0000912 + diencephalon lateral wall mantle layer + mantle layer lateral wall diencephalon + uberon + UBERON:0009580 + diencephalon mantle layer + + + + + mantle layer lateral wall diencephalon + VHOG:0000912 + + + + + + + + + + + + + + + + + + + + + + + + + + EHDAA2:0001172 + EMAPA:16977 + VHOG:0000910 + mantle layer lateral wall midbrain + midbrain lateral wall mantle layer + uberon + mantle layer lateral wall mesencephalon + UBERON:0009581 + midbrain mantle layer + + + + + mantle layer lateral wall midbrain + VHOG:0000910 + + + + + mantle layer lateral wall mesencephalon + VHOG:0000910 + + + + + + + + + + + + + + + + + + + + + + + + + + EMAPA:17580 + VHOG:0000911 + mantle layer lateral wall spinal cord + spinal cord lateral wall mantle layer + uberon + UBERON:0009583 + spinal cord mantle layer + + + + + mantle layer lateral wall spinal cord + VHOG:0000911 + + + + + + + + + + + + + + + + + + + + + + + + + + Mesenchyme that is part of a 1st arch mandibular component. + UBERON:0010043 + EHDAA2:0000034 + EMAPA:16385 + mesenchymal region of mandibular component of first pharyngeal arch + mesenchyme of mandibular component + uberon + mandibular component mesenchyme + mandibular mesenchyme + UBERON:0009584 + 1st arch mandibular mesenchyme + + + + + + + + + + + EMAPA + + + + + Mesenchyme that is part of a 1st arch mandibular component. + OBOL:automatic + + + + + mesenchymal region of mandibular component of first pharyngeal arch + + + + + + mesenchyme of mandibular component + EMAPA:16385 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A neural plate that develops_from a future forebrain. + TAO:0007018 + ZFA:0007018 + uberon + UBERON:0009610 + forebrain neural plate + + + + + + + + + + + + + + + + ZFA + + + + + + + + + + + ZFA + + + + + A neural plate that develops_from a future forebrain. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A neural plate that develops_from a presumptive midbrain. + TAO:0007019 + ZFA:0007019 + uberon + UBERON:0009611 + midbrain neural plate + + + + + + + + + + + + + + + + ZFA + + + + + + + + + + + ZFA + + + + + A neural plate that develops_from a presumptive midbrain. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A neural plate that develops_from a presumptive hindbrain. + TAO:0007022 + ZFA:0007022 + uberon + UBERON:0009614 + hindbrain neural plate + + + + + + + + + + + + + + + + ZFA + + + + + + + + + + + ZFA + + + + + A neural plate that develops_from a presumptive hindbrain. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + TODO - developmental relationships for lines + TAO:0007044 + ZFA:0007044 + MHB neural plate + midbrain-hindbrain boundary neural plate + uberon + UBERON:0009615 + midbrain hindbrain boundary neural plate + + + + + + + + + + + ZFA + + + + + + + + + + + https://github.com/obophenotype/uberon/issues/438 + Bgee:AN + + + + + MHB neural plate + + + + + + midbrain-hindbrain boundary neural plate + ZFA:0007044 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A presumptive structure that has the potential to develop into a midbrain. + TODO - unify naming conventions + + BAMS:MES + EFO:0003432 + EHDAA2:0000615 + EMAPA:16140 + TAO:0000148 + ZFA:0000148 + presumptive mesencephalon + uberon + early midbrain + future midbrain + mesencephalon + UBERON:0009616 + + presumptive midbrain + + + + + + + + + + + ZFA + + + + + + + + + + + ZFA + + + + + A presumptive structure that has the potential to develop into a midbrain. + OBOL:automatic + + + + + presumptive mesencephalon + ZFA:0000148 + + + + + early midbrain + + + + + + future midbrain + + + + + + mesencephalon + EHDAA2:0000615 + + + + + + + + + + + + + + + + EHDAA2:0002094 + trunk and cervical paraxial mesenchyme + uberon + trunk paraxial mesenchyme + UBERON:0009618 + trunk paraxial mesoderm + + + + + trunk and cervical paraxial mesenchyme + EHDAA2:0002094 + + + + + trunk paraxial mesenchyme + + + + + + + + + + + + + + + + + + + + + + + + + + + Nucleus located in the midbrain. + + TAO:0002209 + ZFA:0001665 + uberon + UBERON:0009661 + midbrain nucleus + + + + + Nucleus located in the midbrain. + ZFIN:curator + + + + + + + + + + + + + + + + + + + + + + + + + + Nucleus located within the hindbrain. + TAO:0002177 + ZFA:0001658 + uberon + UBERON:0009662 + hindbrain nucleus + + + + + Nucleus located within the hindbrain. + ZFIN:curator + + + + + + + + + + + + + + + + + + + + + + + + + + A nucleus of brain that is part of a telencephalon. + TAO:0002178 + ZFA:0001660 + uberon + UBERON:0009663 + telencephalic nucleus + + + + + A nucleus of brain that is part of a telencephalon. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical cavity that surrounded_by a stomodeum. + lumen of stomatodaeum + lumen of stomodeum + stomatodeal cavity + uberon + UBERON:0009715 + stomodeal lumen + + + + + An anatomical cavity that surrounded_by a stomodeum. + OBOL:automatic + + + + + + + + + + + + + + + + + EHDAA2:0004621 + EMAPA:32754 + FMA:293087 + uberon + pharyngeal arch endoderm + UBERON:0009722 + entire pharyngeal arch endoderm + + + + + pharyngeal arch endoderm + EHDAA2:0004621 + + + + + + + + + + + + + + + + + + + + + + + + + + + The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing cardiac structures + decide whether to merge with cardiac mesoderm. In EHDAA2 this lasts CS12->unbounded, includes mesenchyme of individual components as parts + EHDAA2:0004162 + EMAPA:36438 + heart mesenchyme + uberon + UBERON:0009751 + + cardiac mesenchyme + + + + + The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing cardiac structures + MP:0011264 + + + + + heart mesenchyme + EMAPA:36438 + + + + + + + + + + + + + + + The many-lobed berry cluster of cells that is the terminous of a gland where the secretion is produced is acinar in form. + acinar + acinus + + FMA:55588 + uberon + acini + UBERON:0009842 + glandular acinus + http://upload.wikimedia.org/wikipedia/commons/9/99/Gray1105.png + + + + + The many-lobed berry cluster of cells that is the terminous of a gland where the secretion is produced is acinar in form. + + + + + + acinus + FMA:55588 + + + + + acini + + + + + + + + + + + + + + + + + + EFO:0003704 + TAO:0005041 + ZFA:0005041 + ALPM + uberon + UBERON:0009881 + + anterior lateral plate mesoderm + + + + + + + + + + + ZFA + + + + + ALPM + ZFA:0005041 + + + + + + + + + + + + + + + + + + + + + + + + + + Mesenchyme that is part of a developing face. + EMAPA:35337 + FMA:302884 + face mesenchyme + mesenchyme of face + uberon + UBERON:0009891 + facial mesenchyme + + + + + Mesenchyme that is part of a developing face. + OBOL:automatic + + + + + + + + + + EHDAA2:0001315 + EHDAA:1122 + uberon + UBERON:0009920 + optic neural crest + + + + + + EHDAA2 + + + + + + + + + + + + + + + + + + + + + + + + + + A multicellular organism that existence_starts_with a post-embryonic stage. + MA:0002405 + postnatal organism + TS28 mouse + post-hatching organism + post-natal organism + postnatal mouse + uberon + UBERON:0009953 + post-embryonic organism + https://github.com/obophenotype/uberon/issues/667 + + + + + A multicellular organism that existence_starts_with a post-embryonic stage. + OBOL:automatic + + + + + TS28 mouse + MA:0002405 + + + + + post-hatching organism + + + + + + post-natal organism + + + + + + postnatal mouse + MA:0002405 + + + + + + + + + An anatomical structure that has more than one cell as a part. + CARO:0010000 + FBbt:00100313 + multicellular structure + uberon + UBERON:0010000 + + multicellular anatomical structure + + + + + + CARO + + + + + An anatomical structure that has more than one cell as a part. + CARO:0010000 + + + + + multicellular structure + FBbt:00100313 + + + + + + + + + + + + + + + + + + + + + + + + + + Mesenchyme that is part of a pharyngeal arch 1. + EMAPA:16128 + mesenchyme of 1st arch + uberon + UBERON:0010042 + 1st arch mesenchyme + + + + + Mesenchyme that is part of a pharyngeal arch 1. + OBOL:automatic + + + + + mesenchyme of 1st arch + EMAPA:16128 + + + + + + + + + + + + + + + + + + + + + + + The sum total of mesenchymal tissue in the pharyngeal arch region. Pharyngeal mesenchyme is undifferentiated, loose connective tissue derived mostly from mesoderm, and also contains ectodermally derived neural crest cells. + EHDAA2:0001459 + EMAPA:16550 + XAO:0004524 + associated mesenchyme of pharyngeal region + entire branchial arch associated mesenchyme + pharyngeal arch associated mesenchyme + uberon + UBERON:0010046 + entire pharyngeal arch associated mesenchyme + + + + + + EHDAA2 + + + + + + + + + + + EHDAA2 + + + + + + + + + + + cjm + + + + + The sum total of mesenchymal tissue in the pharyngeal arch region. Pharyngeal mesenchyme is undifferentiated, loose connective tissue derived mostly from mesoderm, and also contains ectodermally derived neural crest cells. + + XAO:0004524 + + + + + associated mesenchyme of pharyngeal region + EMAPA:16550 + + + + + entire branchial arch associated mesenchyme + + + + + + pharyngeal arch associated mesenchyme + EHDAA2:0001459 + + + + + + + + + + + + + + + + + + + + + + + + + + + Gland of the epithelium lining the oral cavity. The most common are the salivary glands. + Note that Kardong classifies lacrimal glands here. EHDAA2 includes pituitary primordium, as this develops from oral mucosa + UBERON:0003293 + EHDAA2:0001327 + EHDAA:2181 + EMAPA:16572 + EMAPA:16723 + VHOG:0000652 + buccal gland + uberon + gland of oral opening + gland of oral region + mouth gland + oral cavity gland + oral region gland + UBERON:0010047 + oral gland + + + + + Gland of the epithelium lining the oral cavity. The most common are the salivary glands. + ISBN:0073040584 + + + + + Note that Kardong classifies lacrimal glands here. EHDAA2 includes pituitary primordium, as this develops from oral mucosa + EHDAA2 + + + + + + + + + An epithelium consisting of cuboidal epithelial cells. + TODO - coordinate with CL, add cuboidal cell + in NCIT this is glandular + + + NCIT:C32415 + UMLS:C0682577 + uberon + UBERON:0010077 + cuboidal epithelium + + + + + An epithelium consisting of cuboidal epithelial cells. + + + + + + in NCIT this is glandular + NCIT + + + + + UMLS:C0682577 + ncithesaurus:Cuboidal_Epithelium + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Mesenchyme that has the potential to develop into a dermis. + check development + EHDAA2:0000598 + uberon + UBERON:0010083 + future dermis + + + + + + + + + + + EHDAA2 + + + + + + + + + + + EHDAA2 + + + + + + + + + + + XAO + + + + + Mesenchyme that has the potential to develop into a dermis. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A developing anatomical structure that has the potential to develop into a myelencephalon. + EHDAA2:0000640 + uberon + UBERON:0010096 + future myelencephalon + + + + + A developing anatomical structure that has the potential to develop into a myelencephalon. + OBOL:automatic + + + + + + + + + Any portion of cardiac muscle tissue that is part of the conducting system of heart or the Purkinje fibers. + EHDAA2:0004528 + FMA:83378 + specialized conducting tissue of heart + specialized muscle tissue of heart + uberon + UBERON:0010131 + conducting tissue of heart + + + + + Any portion of cardiac muscle tissue that is part of the conducting system of heart or the Purkinje fibers. + + + + + + specialized conducting tissue of heart + FMA:83378 + + + + + specialized muscle tissue of heart + FMA:83378 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical cavity that surrounded_by a blood vessel. + + FMA:312610 + blood vessel lumen + uberon + UBERON:0010161 + lumen of blood vessel + + + + + An anatomical cavity that surrounded_by a blood vessel. + OBOL:automatic + + + + + + + + + A roughly circular bulge in a surface. + requires review + AEO:0000205 + EHDAA2:0003250 + FMA:82506 + uberon + UBERON:0010188 + protuberance + + + + + + FMA + + + + + A roughly circular bulge in a surface. + EHDAA2:0003250 + + + + + + + + + An anatomical boundary that corresponds to some physical discontinuity. + CARO:0001004 + uberon + UBERON:0010199 + + One might argue that all boundaries are actually fiat in the sense that there must be some fiat element at a fine enough scale of granularity. This ontology choses to ignore this issue as below the level of granularity relevant to anatomy. (DOS121102) + bona-fide anatomical boundary + + + + + + CARO + + + + + An anatomical boundary that corresponds to some physical discontinuity. + CARO:0001004 + + + + + + + + + + A nuclear complex which in mammals consists of four parts, the hypothalamus, epithalamus, ventral thalamus, and dorsal thalamus[WP,modified]. + EHDAA2:0004469 + FMA:258745 + uberon + UBERON:0010225 + thalamic complex + + + + + A nuclear complex which in mammals consists of four parts, the hypothalamus, epithalamus, ventral thalamus, and dorsal thalamus[WP,modified]. + + + + + + + + + + + + + + + + + + + + + + Multi-tissue structure that is part of the heart tube and will become the cardiac atrium. + FMA:71005 + TAO:0002228 + ZFA:0001718 + presumptive atrium heart tube + primordial atrium + primordial cardiac atrium + uberon + UBERON:0010227 + future cardiac atrium + + + + + + + + + + + ZFA + + + + + Multi-tissue structure that is part of the heart tube and will become the cardiac atrium. + ZFA:0001718 + + + + + presumptive atrium heart tube + ZFA:0001718 + + + + + primordial atrium + FMA:71005 + + + + + primordial cardiac atrium + FMA:71005 + + + + + + + + + + + + + + + + + + + + + + The core globe-shaped component of the camera-type eye. + See notes for camera-type eye + + + + FMA:12513 + MIAA:0000283 + VHOG:0001616 + bulbus oculi + eye globe + eyeball + uberon + eye + globe + UBERON:0010230 + + eyeball of camera-type eye + + + + + + + + + + + FMA + + + + + The core globe-shaped component of the camera-type eye. + UBERON:cjm + + + + + eye globe + VHOG:0001616 + + + + + eyeball + FMA:12513 + + + + + eye + + + + + + globe + HP:0100886 + MIAA:0000283 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Mesenchyme that develops_from a neural crest and is part of a 1st arch mandibular mesenchyme. + EHDAA2:0000037 + uberon + UBERON:0010252 + 1st arch mandibular mesenchyme from neural crest + + + + + + inferred + + + + + Mesenchyme that develops_from a neural crest and is part of a 1st arch mandibular mesenchyme. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + Mesenchyme that develops_from a rhombencephalon neural crest. + EHDAA2:0004423 + uberon + UBERON:0010258 + mesenchyme from rhombencephalic neural crest + + + + + Mesenchyme that develops_from a rhombencephalon neural crest. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Mesenchyme that develops_from a neural crest and is part of a 1st arch mesenchyme. + EMAPA:16129 + mesenchyme derived from neural crest of mesenchyme of 1st arch + neural crest derived arch 1 mesenchyme + pharyngeal arch 1 mesenchyme from neural crest + uberon + branchial arch 1 mesenchyme from neural crest + UBERON:0010259 + 1st arch mesenchyme from neural crest + + + + + Mesenchyme that develops_from a neural crest and is part of a 1st arch mesenchyme. + OBOL:automatic + + + + + mesenchyme derived from neural crest of mesenchyme of 1st arch + EMAPA:16129 + + + + + + + + + + + + + + + + + + + + + Portion of tissue that is dorsolateral to the floor plate and part of the midbrain. + DHBA:12322 + EFO:0003567 + EHDAA2:0004375 + TAO:0000761 + ZFA:0000761 + basal plate midbrain + basal plate midbrain region + uberon + UBERON:0010285 + + midbrain basal plate + + + + + + EHDAA2 + + + + + + + + + + + EHDAA2 + + + + + + + + + + + ZFA + + + + + Portion of tissue that is dorsolateral to the floor plate and part of the midbrain. + ZFA:0000761 + + + + + basal plate midbrain + TAO:0000761 + + + + + basal plate midbrain region + ZFA:0000761 + + + + + + + + + + + + + + + + Portion of neural tube that gives rise to the midbrain. + we follow ZFA in temporally dividing midbrain NT from presumptive midbrain, but in future this may be collapsed + TAO:0007039 + ZFA:0007039 + uberon + UBERON:0010286 + midbrain neural tube + + + + + + + + + + + ZFA + + + + + Portion of neural tube that gives rise to the midbrain. + ZFA:0007039 + + + + + + + + + + + + + + + + . + + uberon + UBERON:0010291 + layer of sclera + + + + + + + + + + + cjm + + + + + . + + + + + + + + + + + + + + + + + + + + + + + An endothelium that is part of a sclera. + uberon + UBERON:0010294 + scleral endothelium + + + + + + Wikipedia + + + + + An endothelium that is part of a sclera. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Mesenchyme surrounding the developing optic cup which develops into the sclera. + The mesenchyme surrounding the developing optic cup differentiates into the sclera, the dense fibrous coat of the eye.. http://www.ncbi.nlm.nih.gov/pubmed/16496288 + uberon + UBERON:0010299 + scleral mesenchyme + + + + + Mesenchyme surrounding the developing optic cup which develops into the sclera. + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that is part of a extraembryonic structure. + extra-embryonic epithelium + uberon + UBERON:0010303 + extraembryonic epithelium + + + + + An epithelium that is part of a extraembryonic structure. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Developing anatomical structure that develops into the eyeball and associated structures. + Multi-tissue structure that consists of the structures that develop into the retina and lens.[TAO] + TAO:0002201 + ZFA:0001678 + future eye + uberon + UBERON:0010312 + immature eye + + + + + + + + + + + definitional + + + + + Developing anatomical structure that develops into the eyeball and associated structures. + ZFA:0001678 + + + + + Multi-tissue structure that consists of the structures that develop into the retina and lens.[TAO] + 2012-08-14 + TAO:0002201 + TAO + ZFIN:curator + + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical structure that develops from the neural crest. + Grouping term for query purposes + uberon + UBERON:0010313 + + neural crest-derived structure + + + + + An anatomical structure that develops from the neural crest. + + + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical structure that has some part that develops from the neural crest. + Grouping term for query purposes + uberon + UBERON:0010314 + + structure with developmental contribution from neural crest + + + + + An anatomical structure that has some part that develops from the neural crest. + + + + + + + + + + + + + + + + + + uberon + UBERON:0010316 + germ layer / neural crest + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A skeletal element that is part of a orbital region. + uberon + eye skeleton + ocular skeleton + skeletal element of orbital region + UBERON:0010321 + skeletal element of eye region + + + + + A skeletal element that is part of a orbital region. + OBOL:automatic + + + + + + + + + + + + + + + Skeletal subdivision of the head including skull (cranium plus mandible), pharyngeal and/or hyoid apparatus. + we use 'cranial skeletal system', so that we can include the skull, which has joints/sutures as parts (recall, we follow FMA in distinguishing between the skeleton and skeletal system - only the latter includes joints) + that the cranial skeleton includes the pharyngeal arch skeleton. It is thus more inclusive that the cranium itself, and extends beyond the head in tetrapods. The AAO class called 'skull' belongs here, as it includes the whole splanchnocranium + Bony structure that encases the central nervous system and the primary sense organs of sight, olfaction, hearing, and equilibrium.[AAO] + Skeletal system which is part of the skull, including the splanchnocranium, chondrocranium, and dermatocranium.[TAO] + AAO:0000109 + AAO:0000971 + AAO:0010185 + TAO:0000737 + VSAO:0000049 + XAO:0003075 + ZFA:0000737 + cranial skeleton + osteocranium + uberon + cranium + UBERON:0010323 + cranial skeletal system + + + + + Skeletal subdivision of the head including skull (cranium plus mandible), pharyngeal and/or hyoid apparatus. + + GO_REF:0000034 + PSPUB:0000170 + VSAO:0000049 + + + + + Bony structure that encases the central nervous system and the primary sense organs of sight, olfaction, hearing, and equilibrium.[AAO] + 2012-06-20 + AAO:0000109 + AAO + AAO:LAP + + + + + Skeletal system which is part of the skull, including the splanchnocranium, chondrocranium, and dermatocranium.[TAO] + 2012-08-14 + TAO:0000737 + TAO + ZFIN:curator + + + + + cranium + ZFA:0000737 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Mesenchyme that develops_from a neural crest and is part of a mandibular process mesenchyme. + EHDAA2:0004603 + uberon + UBERON:0010336 + mandibular process mesenchyme from neural crest + + + + + + + + + + + EHDAA2 + + + + + Mesenchyme that develops_from a neural crest and is part of a mandibular process mesenchyme. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a mandibular process mesenchyme. + EHDAA2:0004604 + uberon + UBERON:0010337 + mandibular process mesenchyme from head mesenchyme + + + + + + + + + + + EHDAA2 + + + + + Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a mandibular process mesenchyme. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch mandibular mesenchyme. + EHDAA2:0000036 + uberon + UBERON:0010339 + 1st arch mandibular mesenchyme from head mesenchyme + + + + + Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch mandibular mesenchyme. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch mesenchyme. + EMAPA:16130 + mesenchyme derived from head mesoderm of mesenchyme of 1st arch + uberon + UBERON:0010341 + 1st arch mesenchyme from head mesenchyme + + + + + Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch mesenchyme. + OBOL:automatic + + + + + mesenchyme derived from head mesoderm of mesenchyme of 1st arch + EMAPA:16130 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Mesenchyme that develops_from a neural crest and is part of a entire pharyngeal arch associated mesenchyme. + arch mesenchyme from neural crest + branchial arch mesenchyme from neural crest + neural crest derived arch mesenchyme + uberon + UBERON:0010359 + Partially implements https://github.com/obophenotype/uberon/wiki/The-neural-crest NC meeting scheme + pharyngeal arch mesenchyme from neural crest + + + + + Mesenchyme that develops_from a neural crest and is part of a entire pharyngeal arch associated mesenchyme. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a entire pharyngeal arch associated mesenchyme. + arch mesenchyme from head mesenchyme + branchial arch mesenchyme from head mesenchyme + head mesenchyme derived arch mesenchyme + uberon + UBERON:0010360 + Partially implements https://github.com/obophenotype/uberon/wiki/The-neural-crest NC meeting scheme + pharyngeal arch mesenchyme from head mesenchyme + + + + + Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a entire pharyngeal arch associated mesenchyme. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + Epithelium composed of cells that develops from the ectoderm[FMA,modified]. + FMA:69064 + ectoderm-derived epithelium + uberon + UBERON:0010371 + ecto-epithelium + + + + + Epithelium composed of cells that develops from the ectoderm[FMA,modified]. + FMA:69064 + + + + + + + + + + + + + + + + + + + + + + The integrated unit (of the eye) that consists of the conjunctiva, the corneal surface, and the ocular mucosal adnexa including the lid margins and the meibomian gland openings, the lacrimal glands and the lacrimal drainage system, all which are critical to maintain ocular surface integrity and provide protection from external antigens and pathogenic microorganisms. + EMAPA:35336 + MA:0002486 + eye surface + eye surface region + ocular surface + uberon + UBERON:0010409 + + ocular surface region + + + + + The integrated unit (of the eye) that consists of the conjunctiva, the corneal surface, and the ocular mucosal adnexa including the lid margins and the meibomian gland openings, the lacrimal glands and the lacrimal drainage system, all which are critical to maintain ocular surface integrity and provide protection from external antigens and pathogenic microorganisms. + MP:0013754 + + + + + eye surface + MA:0002486 + + + + + + + + + + + + + + + + The ciliary processes are formed by the inward folding of the various layers of the choroid, i.e. , the choroid proper and the lamina basalis, and are received between corresponding foldings of the suspensory ligament of the lens. + + + FMA:76551 + ciliary processes + ciliary processes set + processus ciliares + set of ciliary processes + uberon + ciliary process + processus ciliares + UBERON:0010427 + ciliary processes + http://upload.wikimedia.org/wikipedia/commons/b/b2/Gray875.png + + + + + The ciliary processes are formed by the inward folding of the various layers of the choroid, i.e. , the choroid proper and the lamina basalis, and are received between corresponding foldings of the suspensory ligament of the lens. + + + + + + ciliary processes + FMA:76551 + + + + + ciliary processes set + FMA:76551 + + + + + processus ciliares + FMA:TA + + + + + + set of ciliary processes + FMA:76551 + + + + + ciliary process + + + + + + processus ciliares + + + + + + + + + + + + + + + + + A vessel of the microcirculature, lying between the arterioles and venules; includes capillaries (blood and lymphatic), metarterioles and arteriovenous anastomoses. + MESH:A07.231.432 + TAO:0005251 + ZFA:0005251 + uberon + microcirculatory vessels + UBERON:0010523 + microcirculatory vessel + + + + + + + + + + + ZFA + + + + + A vessel of the microcirculature, lying between the arterioles and venules; includes capillaries (blood and lymphatic), metarterioles and arteriovenous anastomoses. + + MESH:A07.231.432 + ZFA:0005251 + + + + + microcirculatory vessels + TAO:0005251 + + + + + + + + + + + + + + + + + + + + + + Anatomical cluster consisting of the skeletal elements (i.e. bone elements, cartilage elements, cartilage condensations) that are part of an individual subdivision of the organism. Excludes joints. + Anatomical cluster consisting of the skeletal elements that are part of the skeleton.[VSAO] + + FMA:23879 + VSAO:0000042 + skeletal subdivision + uberon + subdivision of skeleton (in vivo) + UBERON:0010912 + + subdivision of skeleton + + + + + + cjm + + + + + + + + + + + UBERONREF:0000003 + + + + + + + + + + + VSAO + + + + + Anatomical cluster consisting of the skeletal elements (i.e. bone elements, cartilage elements, cartilage condensations) that are part of an individual subdivision of the organism. Excludes joints. + + UBERONREF:0000003 + + + + + Anatomical cluster consisting of the skeletal elements that are part of the skeleton.[VSAO] + 2012-08-14 + VSAO:0000042 + incorrect + VSAO + VSAO:curator + + + + + skeletal subdivision + VSAO:0000042 + + + + + subdivision of skeleton (in vivo) + FMA:23879 + + + + + + + + + Joint in which the articulating bones or cartilages are connected by ligaments or fibrocartilage without an intervening synovial cavity. Examples: sagittal suture, inferior tibiofibular syndesmosis, costochondral joint, pubic symphysis. + FMA:7491 + solid joint + uberon + UBERON:0011134 + nonsynovial joint + + + + + + FMA + + + + + Joint in which the articulating bones or cartilages are connected by ligaments or fibrocartilage without an intervening synovial cavity. Examples: sagittal suture, inferior tibiofibular syndesmosis, costochondral joint, pubic symphysis. + FMA:7491 + + + + + solid joint + FMA:7491 + + + + + + + + + + + + + + + + + + + + + + Subdivision of the skeletal system which consists of the axial skeleton plus associated joints. + FMA:7483 + uberon + UBERON:0011137 + axial skeletal system + http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton + + + + + + FMA + + + + + Subdivision of the skeletal system which consists of the axial skeleton plus associated joints. + + + + + + + + + + + + + + + + + Subdivision of the skeletal system which consists of the postcranial axial skeleton plus associated joints. + + axial skeletal system + FMA:302077 + post-cranial axial skeletal system + uberon + UBERON:0011138 + postcranial axial skeletal system + http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton + + + + + + FMA + + + + + + + + + + + cjm + + + + + Subdivision of the skeletal system which consists of the postcranial axial skeleton plus associated joints. + + + + + + + axial skeletal system + + + + + + + + + + + + + + + + + Subdivision of skull that consists of the facial bones. + + EHDAA2:0002206 + EHDAA:8361 + EMAPA:18022 + FMA:53673 + MA:0000318 + facial skeleton + uberon + facial bone + ossa facialia + ossa faciei + viscerocranium + UBERON:0011156 + + facial skeleton + http://upload.wikimedia.org/wikipedia/commons/7/77/Illu_facial_bones.jpg + + + + + + FMA + + + + + + + + + + + FMA + + + + + Subdivision of skull that consists of the facial bones. + + + + MP:0005274 + + + + + facial skeleton + FMA:53673 + + + + + facial bone + MA:0000318 + + + + + ossa facialia + + + + + + + ossa faciei + + + + + + + viscerocranium + MA:0000318 + + + + + + + + + + + + + + + + The skull can be divided into two: the neurocranium and the facial skeleton + FMA:54964 + skull subdivision + subdivision of skull + uberon + UBERON:0011158 + + primary subdivision of skull + + + + + + FMA + + + + + The skull can be divided into two: the neurocranium and the facial skeleton + + + + + + skull subdivision + FMA:54964 + + + + + subdivision of skull + FMA:54964 + + + + + + + + + + + + + + + uberon + UBERON:0011159 + + primary subdivision of cranial skeletal system + + + + + + FMA + + + + + + + + + + + + + + + + + + + + + + + + + + + A multi cell part structure that is part of a central nervous system. + FMA:83143 + cell part cluster of neuraxis + neuraxis layer + uberon + UBERON:0011215 + + central nervous system cell part cluster + + + + + A multi cell part structure that is part of a central nervous system. + OBOL:automatic + + + + + cell part cluster of neuraxis + FMA:83143 + + + + + neuraxis layer + FMA:83143 + + + + + + + + + + + + + + + A subdivision of an anatomical system. + + FBbt:00007330 + FMA:67509 + uberon + UBERON:0011216 + + organ system subdivision + + + + + + FBbt + + + + + A subdivision of an anatomical system. + + + + + + + + + + + + + + + + + Muscles within the eye (bulbus oculi).[AAO] + AAO:0010038 + EMAPA:18808 + FMA:49150 + intrinsic muscle of eyeball + intrinsic ocular muscle + uberon + UBERON:0011222 + intra-ocular muscle + + + + + + + + + + + EMAPA + + + + + Muscles within the eye (bulbus oculi).[AAO] + 2012-06-20 + AAO:0010038 + AAO + AAO:EJS + + + + + intrinsic ocular muscle + EMAPA:18808 + + + + + + + + + + + + + + + The part of the trunk that is in the dorsum[cjm]. + In humans, the subdivision of trunk which is demarcated from the trunk proper by the external surface of the posterolateral part of the rib cage, the anterior surface of the thoracic vertebral column and the posterior axillary lines, the external surface of the posterior abdominal wall; together with the trunk proper, it constitutes the trunk[FMA] + + EMAPA:35162 + FMA:25056 + MA:0000020 + back of trunk + dorsal part of trunk + dorsum of trunk + trunk back + uberon + UBERON:0011270 + dorsal trunk + + + + + + FMA + + + + + + + + + + + FMA + + + + + The part of the trunk that is in the dorsum[cjm]. + + UBERONREF:0000006 + + + + + back of trunk + FMA:25056 + + + + + dorsum of trunk + FMA:25056 + + + + + trunk back + FMA:25056 + + + + + + + + + + + + + + + + + + + + + + compare with 'stratum basale of epidermis'. This class is the source for many adult structures - see WP2062. See also: 'enveloping layer of ectoderm' + EHDAA2:0001845 + uberon + basal cell layer of skin + outer epithelium of body + UBERON:0011272 + embryonic skin basal layer + + + + + + EHDAA2 + + + + + + + + + + + EHDAA2 + + + + + + + + + + + EHDAA2 + + + + + outer epithelium of body + Wikipathways:WP2062 + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of gray matter that is part of a telencephalon. + UBERON:0024186 + BIRNLEX:1067 + FMA:83911 + predominantly gray regional part of telencephalon + uberon + UBERON:0011300 + gray matter of telencephalon + + + + + A portion of gray matter that is part of a telencephalon. + OBOL:automatic + + + + + predominantly gray regional part of telencephalon + BIRNLEX:1067 + + + + + + + + + + + + + + + + + + + + + A blood vasculature that is part of a head. + Blood vessel part of cranial vasculature.[TAO] + TAO:0005297 + ZFA:0005297 + cranial blood vessel + set of blood vessels of head + uberon + cranial blood vessels + UBERON:0011362 + cranial blood vasculature + + + + + A blood vasculature that is part of a head. + OBOL:automatic + + + + + Blood vessel part of cranial vasculature.[TAO] + 2012-08-14 + TAO:0005297 + TAO + ZFIN:curator + + + + + cranial blood vessel + ZFA:0005297 + + + + + cranial blood vessels + TAO:0005297 + + + + + + + + + + Anatomical structure that is an aggregation of similar cells from which cartilages and bones form, and from which chondrogenesis and osteogenesis are initiated during repair and/or regeneration. (Hall and Miyake 1995). + consider obsoleting, coordinate with VSAO + VSAO:0000006 + XAO:0004021 + uberon + UBERON:0011585 + cell condensation + + + + + + VSAO + + + + + Anatomical structure that is an aggregation of similar cells from which cartilages and bones form, and from which chondrogenesis and osteogenesis are initiated during repair and/or regeneration. (Hall and Miyake 1995). + + GO_REF:0000034 + PSPUB:0000170 + VSAO:0000006 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A subdivision of the head that corresponds to the jaw skeleton, containing both soft tissue, skeleton and teeth (when present). The jaw region is divided into upper and lower regions. + EMAPA:32905 + NCIT:C114916 + uberon + UBERON:0011595 + jaw region + http://eol.org/collections/11578 + + + + + + + + + + + EMAPA + FMA-abduced + ZFA-abduced + + + + + A subdivision of the head that corresponds to the jaw skeleton, containing both soft tissue, skeleton and teeth (when present). The jaw region is divided into upper and lower regions. + + + + + + + + + + + + + + + + + EHDAA2:0001020 + lower jaw future lip + uberon + UBERON:0011596 + future lower lip + + + + + + EHDAA2 + + + + + + + + + + + + + + + + lower jaw future lip + EHDAA2:0001020 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An epithelium that develops_from a ectoderm and is part of a oral epithelium. + EHDAA2:0004137 + uberon + UBERON:0011642 + oral epithelium from ectoderm + + + + + + EHDAA2 + + + + + + + + + + + EHDAA2 + + + + + An epithelium that develops_from a ectoderm and is part of a oral epithelium. + OBOL:automatic + + + + + + + + + + + + + + + A major subdivision of an organism that divides an organism along its main body axis (typically anterio-posterior axis). In vertebrates, this is based on the vertebral column. + Ideally this would be disjoint with analagous class for appendicular axes, but currently 'appendages' like antennae, horns cause a problem + axial subdivision of organism + uberon + body segment + main body segment + UBERON:0011676 + + subdivision of organism along main body axis + + + + + A major subdivision of an organism that divides an organism along its main body axis (typically anterio-posterior axis). In vertebrates, this is based on the vertebral column. + + + + + + + + + + + + + + + + + + + + + + + + + + + A cardiovascular system that is part of a conceptus. + EHDAA2:0000216 + FMA:305965 + NCIT:C34148 + conceptus cardiovascular system + uberon + embryonic circulatory system + fetal circulatory system + UBERON:0011695 + embryonic cardiovascular system + + + + + A cardiovascular system that is part of a conceptus. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A neural nucleus that is part of the spinal cord. + FMA:77011 + spinal cord nucleus + uberon + UBERON:0011777 + + nucleus of spinal cord + + + + + A neural nucleus that is part of the spinal cord. + + + + + + spinal cord nucleus + FMA:77011 + + + + + + + + + Ectodermal placode that does not develop into a component of the nervous system. + uberon + UBERON:0011814 + non-neurogenic ectodermal placode + + + + + + cjm + + + + + Ectodermal placode that does not develop into a component of the nervous system. + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical junction that divides and overlaps with and atrium and a ventricle in the heart. + EHDAA2:0004149 + FMA:85125 + uberon + AV region + AV segment + atrial ventricular junction + atrioventricular junction + atrioventricular segment + UBERON:0011820 + atrioventricular region + + + + + An anatomical junction that divides and overlaps with and atrium and a ventricle in the heart. + + + + + + AV region + + + + + + AV segment + + + + + + atrial ventricular junction + GO:0003294 + + + + + atrioventricular junction + FMA:85125 + GO:0003294 + + + + + atrioventricular segment + + + + + + + + + + Connective tissue, which consists of a population of connective tissue cells, the intercellular matrix of which contains an irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, mucoid tissue, connective tissue of peritoneum, connective tissue of fibrous pericardium. + FMA:20107 + uberon + UBERON:0011821 + irregular connective tissue + + + + + + FMA + + + + + Connective tissue, which consists of a population of connective tissue cells, the intercellular matrix of which contains an irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, mucoid tissue, connective tissue of peritoneum, connective tissue of fibrous pericardium. + FMA:20107 + + + + + + + + + + Irregular connective tissue is an irregular connective tissue, the intercellular matrix of which contains a dense irregular network of collagen and elastic fiber bundles. Examples: connective tissue of peritoneum, connective tissue of fibrous pericardium. + Tissue characterized by a thick, random arrangement of collagen and elastin fibers with very few cells. The majority of the cells are fibroblasts, but mast cells and macrophages may also be seen. It is found in the dermis, periosteum, perichondrium, capsules of organs and sheaths of nerves and muscles[NCIT] + + + FMA:20109 + NCIT:C32882 + UMLS:C0738366 + irregular dense connective tissue + typus irregularis (textus connectivus collagenosus compactus) + uberon + UBERON:0011822 + dense irregular connective tissue + + + + + + FMA + + + + + Irregular connective tissue is an irregular connective tissue, the intercellular matrix of which contains a dense irregular network of collagen and elastic fiber bundles. Examples: connective tissue of peritoneum, connective tissue of fibrous pericardium. + + FMA:20109 + + + + + Tissue characterized by a thick, random arrangement of collagen and elastin fibers with very few cells. The majority of the cells are fibroblasts, but mast cells and macrophages may also be seen. It is found in the dermis, periosteum, perichondrium, capsules of organs and sheaths of nerves and muscles[NCIT] + 2012-08-29 + ncithesaurus:Irregular_Dense_Connective_Tissue + NCIT + + + + + UMLS:C0738366 + ncithesaurus:Irregular_Dense_Connective_Tissue + + + + + typus irregularis (textus connectivus collagenosus compactus) + FMA:20109 + + + + + + + + + + + + + + + + + + + + + + + + + + + Dense connective tissue is mainly composed of collagen type I. Crowded between the collagen fibers are rows of fibroblasts, fiber-forming cells, that manufacture the fibers. Dense connective tissue forms strong, rope-like structures such as tendons and ligaments. Tendons attach skeletal muscles to bones; ligaments connect bones to bones at joints. Ligaments are more stretchy and contain more elastic fibers than tendons. Dense connective tissue also make up the lower layers of the skin (dermis), where it is arranged in sheets + our OWL definition states that this is differentiated from other connective tissue types by virtue of the fact that the collage fiber component predominates, as opposed to cells and fluid. + Connective tissue in which the fibrous component predominates. The cells, ground substance, and tissue fluid represent a minor component[NCIT] + + + AAO:0000121 + NCIT:C32450 + UMLS:C1511770 + uberon + UBERON:0011823 + dense connective tissue + + + + + Dense connective tissue is mainly composed of collagen type I. Crowded between the collagen fibers are rows of fibroblasts, fiber-forming cells, that manufacture the fibers. Dense connective tissue forms strong, rope-like structures such as tendons and ligaments. Tendons attach skeletal muscles to bones; ligaments connect bones to bones at joints. Ligaments are more stretchy and contain more elastic fibers than tendons. Dense connective tissue also make up the lower layers of the skin (dermis), where it is arranged in sheets + + + + + + Connective tissue in which the fibrous component predominates. The cells, ground substance, and tissue fluid represent a minor component[NCIT] + 2012-08-29 + ncithesaurus:Dense_Connective_Tissue + NCIT + + + + + UMLS:C1511770 + ncithesaurus:Dense_Connective_Tissue + + + + + + + + + + FMA:75634 + uberon + UBERON:0011824 + fibrous connective tissue + + + + + + FMA + + + + + + + + + Irregular connective tissue, the intercellular matrix of which contains a sparse irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, neuroglial tissue, mucoid tissue. + + + FMA:19783 + NCIT:C33007 + UMLS:C1253917 + textus connectivus collagenosus laxus + textus connectivus laxus + uberon + UBERON:0011825 + loose connective tissue + + + + + + FMA + + + + + Irregular connective tissue, the intercellular matrix of which contains a sparse irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, neuroglial tissue, mucoid tissue. + FMA:19783 + + + + + UMLS:C1253917 + ncithesaurus:Loose_Connective_Tissue + + + + + textus connectivus collagenosus laxus + FMA:19783 + FMA:TA + + + + + + textus connectivus laxus + FMA:19783 + FMA:TA + + + + + + + + + + + + + + + + + + + + + + + + + + + An acinus that is part of a exocrine gland. + exocrine gland acinus + uberon + UBERON:0011858 + acinus of exocrine gland + + + + + An acinus that is part of a exocrine gland. + OBOL:automatic + + + + + + + + + the FMA class specifically refers to ureter + FMA:63212 + MESH:D024022 + NCIT:C32339 + NIF_Subcellular:sao7547390221 + uberon + UBERON:0011860 + collection of collagen fibrils + + + + + + + ZFA + + + + + the FMA class specifically refers to ureter + FMA + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Front (ventral) portion of the vascular, pigmentary, or middle coat of the eye, including the ciliary body and the iris. + + EMAPA:37417 + Haller tunica vascula + anterior part of uveal tract + anterior uveal tract + anterior vascular layer of the eyeball + anterior vascular tunic of the eye + tunica vasculosa bulbosa + ventral uveal tract + uberon + ciliary body and iris + vasculosa oculi + UBERON:0011892 + + anterior uvea + + + + + + ZFA + + + + + + + + + + + MP + + + + + + lexical + + + + + Front (ventral) portion of the vascular, pigmentary, or middle coat of the eye, including the ciliary body and the iris. + MP:0005194 + + + + + EMAPA:37417 + MA:th + + + + + Haller tunica vascula + MP:0005194 + + + + + tunica vasculosa bulbosa + MP:0005194 + + + + + vasculosa oculi + MP:0005194 + + + + + + + + + The aggregate of the coelemic cavity lumen plus the membranes that line the lumen. + EHDAA2 distingsuishes between the lumen, the lining, and the 'coelomic cavity', which despire it's name, is not a space - it is the aggregate of space plus lining. + coelomic + + EHDAA2:0004731 + enterocoelom + haemocoelom + schizocoelom + uberon + coelem + coelomic cavity + UBERON:0011997 + coelom + + + + + + EHDAA2 + + + + + The aggregate of the coelemic cavity lumen plus the membranes that line the lumen. + + + UBERON:cjm + + + + + enterocoelom + NCBITaxon:33511 + + + + + coelomic cavity + EHDAA2:0004731 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Anatomical system that consists of the integumental system plus all mucosae and submucosae. + + + uberon + dermatological system + UBERON:0012125 + dermatological-muscosal system + + + + + Anatomical system that consists of the integumental system plus all mucosae and submucosae. + + + + + + dermatological system + OBI:MC + + + + + + + + + + + + + + + + + + + + + + + + + + A zone of skin that is part of a craniocervical region. + + EMAPA:37276 + MA:0000574 + NCIT:C12294 + UMLS:C1522650 + uberon + UBERON:0012180 + head or neck skin + + + + + A zone of skin that is part of a craniocervical region. + OBOL:automatic + + + + + EMAPA:37276 + MA:th + + + + + UMLS:C1522650 + ncithesaurus:Skin_of_the_Scalp_and_Neck + + + + + + + + + + + + + + + + + + + + + Epithelium that derives from the mesoderm. [Automatically generated definition]. + FMA:86452 + mesoderm-derived epithelium + mesoepithelium + uberon + UBERON:0012275 + meso-epithelium + + + + + Epithelium that derives from the mesoderm. [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + One of five swellings formed during the development of the face + + FMA:293103 + uberon + embryonic facial process + facial primordium + primordium of face + UBERON:0012314 + embryonic facial prominence + + + + + One of five swellings formed during the development of the face + + + + + + + + + + + + + + + + + + + + + + An artery of the neck + + EMAPA:37075 + NCIT:C52850 + UMLS:C1707349 + uberon + UBERON:0012320 + cervical artery + + + + + An artery of the neck + + + + + + EMAPA:37075 + MA:th + + + + + UMLS:C1707349 + ncithesaurus:Cervical_Artery + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The deep cervical artery (Profunda cervicalis) is an artery of the neck. + + + FMA:10659 + uberon + profunda cervicalis + UBERON:0012321 + deep cervical artery + + + + + + + + + + + FMA + + + + + The deep cervical artery (Profunda cervicalis) is an artery of the neck. + + + + + + profunda cervicalis + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A layer of tissue between the muscularis and serosa. + + + + FMA:45636 + NCIT:C94494 + UMLS:C0225334 + uberon + UBERON:0012375 + Contains nerves, blood vessels, lymphatics and lymph nodes + subserosa + + + + + A layer of tissue between the muscularis and serosa. + + + + + + UMLS:C0225334 + ncithesaurus:Subserosa + + + + + + + + + + + + + + + + + + + + + + + + + + + EMAPA:37567 + MA:0001802 + uberon + UBERON:0012416 + respiratory system arterial smooth muscle + + + + + EMAPA:37567 + MA:th + + + + + + + + + + + + + + + + + + + + + + + + + + A smooth muscle tissue that is part of a respiratory system venous blood vessel. + EMAPA:37586 + MA:0001812 + uberon + UBERON:0012418 + respiratory system venous smooth muscle + + + + + A smooth muscle tissue that is part of a respiratory system venous blood vessel. + OBOL:automatic + + + + + EMAPA:37586 + MA:th + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The sclera and cornea form the fibrous tunic of the bulb of the eye; the sclera is opaque, and constitutes the posterior five-sixths of the tunic; the cornea is transparent, and forms the anterior sixth. + + tunica fibrosa + + + FMA:58102 + fibrous layer of eyeball + uberon + corneosclera + fibrous tunic + UBERON:0012430 + tunica fibrosa of eyeball + + + + + + FMA + + + + + The sclera and cornea form the fibrous tunic of the bulb of the eye; the sclera is opaque, and constitutes the posterior five-sixths of the tunic; the cornea is transparent, and forms the anterior sixth. + + + + + + + + + + + + fibrous layer of eyeball + FMA:58102 + + + + + corneosclera + + + + + + fibrous tunic + + + + + + + + + + + + + + + + + + + + + + + + + + + EHDAA2:0000472 + EMAPA:16054 + VHOG:0000767 + uberon + extraembryonic cavities + UBERON:0012466 + extraembryonic cavity + + + + + extraembryonic cavities + EHDAA2:0000472 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A vein that drains a lip. + + labial vein of face + lip vein + vena labialis + uberon + labial vein + UBERON:0013136 + vein of lip + + + + + + + + + + + FMA + + + + + A vein that drains a lip. + OBOL:automatic + + + + + lip vein + OBOL:automatic + + + + + vena labialis + + + + + + + + + + + + + + + + + + + + + + + + + + + Any vein within the general circulation that transports blood back to the right atrium of the heart. + + + FMA:66644 + NCIT:C33719 + UMLS:C0447117 + systemic venous tree organ part + uberon + UBERON:0013140 + systemic vein + + + + + Any vein within the general circulation that transports blood back to the right atrium of the heart. + ncithesaurus:Systemic_Vein + + + + + UMLS:C0447117 + ncithesaurus:Systemic_Vein + + + + + systemic venous tree organ part + FMA:66644 + + + + + + + + + + + + + + + + + + + + + + + + + + The secretory unit of a serous gland. The acinar portion is composed of serous secreting cells. + FMA:86279 + acinus of serous gland + uberon + UBERON:0013232 + serous acinus + + + + + The secretory unit of a serous gland. The acinar portion is composed of serous secreting cells. + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Anatomical cavity that is the lumen of the skull and contains the brain. + + + + + EMAPA:37497 + FMA:9644 + MA:0003061 + NCIT:C77638 + UMLS:C0230041 + cavitas cranii + uberon + intracranial cavity + intracranial space + UBERON:0013411 + cranial cavity + http://upload.wikimedia.org/wikipedia/commons/e/ee/Scheme_body_cavities-en.svg + + + + + + + + + + + Wikipedia + + + + + Anatomical cavity that is the lumen of the skull and contains the brain. + UBERON:cjm + + + + + EMAPA:37497 + MA:th + + + + + UMLS:C0230041 + ncithesaurus:Cranial_Cavity + + + + + cavitas cranii + FMA:9644 + FMA:TA + + + + + + intracranial cavity + + + + + + intracranial space + + + + + + + + + + + + + + + + + + + + + + + + + + + The space that surrounds an organism. + external to organism + outside of body + uberon + UBERON:0013514 + space surrounding organism + + + + + The space that surrounds an organism. + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + uberon + UBERON:0013522 + subdivision of tube + + + + + + + + + + + + + + 2 + + + + + 2 + + + + + + + + + + + + + + + + + + An anatomical space which is the lumen of some anatomical conduit and connects two or more spaces together[FMA,modified]. + FMA:9338 + foramen space + uberon + UBERON:0013686 + anatomical conduit space + + + + + + FMA + + + + + An anatomical space which is the lumen of some anatomical conduit and connects two or more spaces together[FMA,modified]. + + FMA:9338 + + + + + + + + + + + + + + + + + + + + + + + + + + + Vascular endothelium found in blood vessels of the blood-brain-barrier. + BTO:0001852 + BTO:0003248 + CALOHA:TS-0092 + uberon + cerebromicrovascular endothelium + UBERON:0013694 + brain endothelium + + + + + Vascular endothelium found in blood vessels of the blood-brain-barrier. + CALOHA:TS-0092 + + + + + cerebromicrovascular endothelium + CALOHA:TS-0092 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Musculature of the head and neck, spine, and ribs. + EHDAA2:0000159 + EMAPA:18166 + uberon + UBERON:0013700 + axial musculature + + + + + Musculature of the head and neck, spine, and ribs. + HP:0003327 + + + + + + + + + A principle subdivision of an organism that includes all structures along the primary axis, typically the anterior-posterior axis, from head to tail, including structures of the body proper where present (for example, ribs), but excluding appendages. + uberon + UBERON:0013701 + + main body axis + + + + + A principle subdivision of an organism that includes all structures along the primary axis, typically the anterior-posterior axis, from head to tail, including structures of the body proper where present (for example, ribs), but excluding appendages. + + + + + + + + + + + + + + + + The region of the organism associated with the visceral organs. + Cardinal body part, which consists of a maximal set of diverse subclasses of organ and organ part spatially associated with the vertebral column and ribcage. Examples: There is only one body proper[FMA:231424]. + AEO:0000103 + BTO:0001489 + EMAPA:36031 + FMA:231424 + uberon + body + whole body + UBERON:0013702 + + body proper + + + + + + AEO + + + + + The region of the organism associated with the visceral organs. + AEO:0000103 + + + + + Cardinal body part, which consists of a maximal set of diverse subclasses of organ and organ part spatially associated with the vertebral column and ribcage. Examples: There is only one body proper[FMA:231424]. + FMA:231424 + + + + + body + AEO:0000103 + + + + + whole body + BTO:0001489 + + + + + + + + + + + + + + + + + + + + + + + + + + + A tubular passage that extends from the primitive pit into the head process during the early stages of embryonic development in mammals. It perforates the splanchnopleure layer so that the yolk sac and the amnion are connected temporarily. + + FMA:293127 + NCIT:C34230 + UMLS:C1518428 + uberon + chordal canal + UBERON:0013704 + notochordal canal + + + + + A tubular passage that extends from the primitive pit into the head process during the early stages of embryonic development in mammals. It perforates the splanchnopleure layer so that the yolk sac and the amnion are connected temporarily. + + + + + + UMLS:C1518428 + ncithesaurus:Notochordal_Canal + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Fluid contained within the notochordal canal + notochord fluid + portion of notochordal fluid + uberon + UBERON:0013727 + Distinct feature of coelocanths + notochordal fluid + + + + + Fluid contained within the notochordal canal + + + + + + + + + + + + + + + + + + + + + + + + + + + + A organ component layer that is part of a integumental system. + + layer of skin + skin layer + uberon + UBERON:0013754 + + integumentary system layer + + + + + A organ component layer that is part of a integumental system. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A blood that is part of a artery. + FMA:83066 + arterial blood + blood in artery + portion of arterial blood + uberon + UBERON:0013755 + + arterial blood + + + + + A blood that is part of a artery. + OBOL:automatic + + + + + arterial blood + FMA:83066 + + + + + blood in artery + FMA:83066 + + + + + portion of arterial blood + FMA:83066 + + + + + + + + + + + + + + + + + + + + + + + + + + A blood that is part of a vein. + FMA:83067 + blood in vein + portion of venous blood + venous blood + uberon + UBERON:0013756 + venous blood + + + + + A blood that is part of a vein. + OBOL:automatic + + + + + blood in vein + FMA:83067 + + + + + portion of venous blood + FMA:83067 + + + + + venous blood + FMA:83067 + + + + + + + + + + + + + + + + + + + + + + + + + + A blood that is part of a capillary. + FMA:263901 + NCIT:C32212 + blood in capillary + portion of blood in capillary + portion of capillary blood + uberon + UBERON:0013757 + capillary blood + + + + + A blood that is part of a capillary. + OBOL:automatic + + + + + portion of blood in capillary + FMA:263901 + + + + + + + + + + + + + + + + + + + + + + + + + + Any of the organs or elements that are part of the digestive system. Examples: tongue, esophagus, spleen, crop, lunge feeding organ, tooth elements. + + EMAPA:37843 + digestive organ + digestive system organ + uberon + UBERON:0013765 + + + digestive system element + + + + + Any of the organs or elements that are part of the digestive system. Examples: tongue, esophagus, spleen, crop, lunge feeding organ, tooth elements. + + + + + + EMAPA:37843 + MA:th + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Embryonic structure that gives rise to the telencephalon. + EHDAA2:0004424 + EMAPA:36024 + TAO:0000571 + ZFA:0000571 + presumptive telencephalon + uberon + UBERON:0014371 + paired anteriolateral division of the embryonic prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived[MP] + future telencephalon + + + + + + + + + + + definitional + + + + + Embryonic structure that gives rise to the telencephalon. + ZFA:0000571 + ZFA:curator + + + + + presumptive telencephalon + ZFA:0000571 + + + + + + + + + + + + + + + + + + + + + Mesenchyme that develops_from the neural crest[Automatically generated definition]. + EMAPA:32735 + FMA:293883 + mesenchyme from neural crest + neural crest derived mesenchyme + neural crest mesenchyme + uberon + UBERON:0014387 + mesenchyme derived from neural crest + + + + + Mesenchyme that develops_from the neural crest[Automatically generated definition]. + + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + Subdivision of skeletal system that consists of all skeletal elements in the thoracic region of the trunk. In most vertebrates this is the rib cage and sternum. + + EHDAA2:0002013 + FMA:77169 + skeleton of thorax + thoracic part of axial skeleton + thoracic skeleton + uberon + UBERON:0014477 + + thoracic skeleton + + + + + Subdivision of skeletal system that consists of all skeletal elements in the thoracic region of the trunk. In most vertebrates this is the rib cage and sternum. + + + + + + + thoracic skeleton + EHDAA2:0002013 + + + + + + + + + + + + + + + + + + + + + + + + + + A neuromere that is part of the presumptive forebrain + forebrain segment + segment of forebrain + FMA:61996 + forebrain neuromere + uberon + future prosencephalon + UBERON:0014775 + prosomere + + + + + A neuromere that is part of the presumptive forebrain + + + + + + + + + + + + + + + + + + + + + + + + + + + A neuromere that is part of the presumptive midbrain + mesomere + midbrain segment + segment of midbrain + EHDAA2:0004352 + FMA:61997 + mesomere of nervous system + neuromere of mesomere group + uberon + future mesencephalon + mesomere group + UBERON:0014776 + midbrain neuromere + + + + + A neuromere that is part of the presumptive midbrain + + + + + + mesomere group + EHDAA2:0004352 + + + + + + + + + + + + + + + + + + + + + + + + + + A neuromere that is part of the presumptive spinal cord + TAO:0001332 + ZFA:0001332 + spinal cord metameric segment + spinal neuromeres + uberon + spinal cord segment + UBERON:0014777 + spinal neuromere + + + + + A neuromere that is part of the presumptive spinal cord + + + + + + spinal neuromeres + TAO:0001332 + + + + + + spinal cord segment + TAO:0001332 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A portion of tissue that will develop into vasculature. + EFO:0003708 + TAO:0005076 + ZFA:0005076 + uberon + UBERON:0014903 + primordial vasculature + + + + + A portion of tissue that will develop into vasculature. + ZFA:0005076 + ZFA:curator + + + + + + + + + + + + + + + + these layers primarily refer to the mammalian future neocortex + uberon + UBERON:0014950 + layer of developing cerebral cortex + + + + + + + + + + + EMAPA + + + + + + + + + + + + + + + consider merging into myocardial compact layer + FMA:83105 + perimysial connective tissue of subepicardium + subepicardial connective tissue + uberon + UBERON:0015128 + subepicardial layer of epicardium + + + + + + + + + + + FMA + + + + + perimysial connective tissue of subepicardium + FMA:83105 + + + + + subepicardial connective tissue + FMA:83105 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Visceral intrapericardial fat contiguous with the myocardial surface. + + FMA:9871 + epicardial adipose tissue + pericardial adipose tissue + uberon + UBERON:0015129 + epicardial fat + + + + + Visceral intrapericardial fat contiguous with the myocardial surface. + + + + + + + + + + + + + + + + + + + + + + + + + + + A gland that is typically found in or near the orbital region, in or around either the medial or lateral canthi, and is typically associated with secretions onto the eyeball or associated ducts. Includes the Harderian, nictitans and lacrimal glands. + the only orbital gland found in anuran amphibians is either the Harderian or the lacrimal; if it is a lacrimal, then a progressive lateral migration of the lacrimal glands must occur through the amniotes[PMID:7559104] + the only orbital gland found in anuran amphibians is the Harderian[PMID:8843648] + + ocular gland + uberon + orbital gland + UBERON:0015152 + gland of ocular region + + + + + + + + + + + inferred + + + + + A gland that is typically found in or near the orbital region, in or around either the medial or lateral canthi, and is typically associated with secretions onto the eyeball or associated ducts. Includes the Harderian, nictitans and lacrimal glands. + + + + + + + + + + + + + + + + + + + + + + + + + + + + An eye consisting of multiple light-sensing organs + + + + uberon + UBERON:0015165 + multi-unit eye + + + + + An eye consisting of multiple light-sensing organs + + + + + + + + present on tentacular crown + + + + + + + present on mantle edge in arcacean Bivalvia + + + + + + + The eyes (optic cushions) on the oral surface of Asteroida (Echinodermata), close to the base of the terminal tentacles, are also composed of a number of simple ocelli - as many as 80-200 in certain species + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A region of somite adjacent to presomitic mesoderm. + TAO:0001462 + XAO:0004074 + ZFA:0001462 + uberon + inter-somited border + intersomitic boundary + intersomitic fissure + intersomitic junction + segmental border + somite boundary + UBERON:0015178 + + somite border + + + + + A region of somite adjacent to presomitic mesoderm. + + + + + + intersomitic junction + XAO:0004074 + + + + + somite boundary + ZFA:0001462 + + + + + + + + + + + + + + + + + + + + + + + + + + + Epithelium located in the intersomitic region. + XAO:0004077 + intersomitic epithelium + intersomitic membrane + uberon + UBERON:0015179 + somite boundary epithelium + + + + + Epithelium located in the intersomitic region. + XAO:0004077 + XAO:EJS + + + + + intersomitic epithelium + XAO:0004077 + + + + + intersomitic membrane + XAO:0004077 + + + + + + + + + + + + + + + + + + + + + + + + + + Any structure that is placed on one side of the left-right axis of a bilaterian. + This class is primarily to implement taxon constraints. It may be removed in the future. + uberon + UBERON:0015212 + + + lateral structure + + + + + Any structure that is placed on one side of the left-right axis of a bilaterian. + + + + + + + + + + + + + + + + A hollow, muscular organ, which, by contracting rhythmically, contributes to the circulation of lymph, blood or analogs. Examples: a chambered vertebrate heart; the tubular peristaltic heart of ascidians; the dorsal vessel of an insect; the lymoh heart of a reptile. + heart + SPD:0000130 + cardiac pump + heart or heart like organ + circulatory vessel + uberon + cardiac structure + UBERON:0015228 + + circulatory organ + + + + + A hollow, muscular organ, which, by contracting rhythmically, contributes to the circulation of lymph, blood or analogs. Examples: a chambered vertebrate heart; the tubular peristaltic heart of ascidians; the dorsal vessel of an insect; the lymoh heart of a reptile. + + + + + + + + + + + + + + + + + + + + + + + + + + + A basement membrane of epithelium that is part of a respiratory system. + EMAPA:37570 + MA:0001815 + uberon + UBERON:0015329 + respiratory system basement membrane + + + + + + + + + + + MA + + + + + A basement membrane of epithelium that is part of a respiratory system. + OBOL:automatic + + + + + EMAPA:37570 + MA:th + + + + + + + + + + + + + + + EMAPA:37597 + MA:0002449 + heart/pericardium + uberon + UBERON:0015410 + heart plus pericardium + + + + + + MA + + + + + EMAPA:37597 + MA:th + + + + + heart/pericardium + MA:0002449 + + + + + + + + + + + + + + + + + + + + + + + + + + A smooth muscle tissue that is part of a hypodermis. + FMA:77862 + muscle layer in fatty layer of subcutaneous tissue + stratum musculosum panniculi adiposi telae subcutaneae + uberon + UBERON:0015783 + smooth muscle layer in fatty layer of subcutaneous tissue + + + + + A smooth muscle tissue that is part of a hypodermis. + OBOL:automatic + + + + + muscle layer in fatty layer of subcutaneous tissue + FMA:77862 + + + + + stratum musculosum panniculi adiposi telae subcutaneae + FMA:77862 + FMA:TA + + + + + + + + + + + + + + + + + + + + + + + + + + + + A epithelium that is part of a camera-type eye. + EMAPA:35957 + MA:0003162 + uberon + UBERON:0015808 + eye epithelium + + + + + A epithelium that is part of a camera-type eye. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + A epithelium that is part of a foregut. + EMAPA:32922 + MA:0003204 + uberon + UBERON:0015833 + foregut epithelium + + + + + A epithelium that is part of a foregut. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The external part of the developing pharynx that is made of ectoderm. During vertebrate development, pockets form in pharyngeal ectoderm between the pharyngeal arches. + UBERON:2001379 + TAO:0001379 + ZFA:0001379 + uberon + UBERON:0016545 + pharyngeal ectoderm + + + + + The external part of the developing pharynx that is made of ectoderm. During vertebrate development, pockets form in pharyngeal ectoderm between the pharyngeal arches. + + + + + + + + + + + + + + + + + + + + + + + + + + + + A layer of of the central nervous system that is part of gray matter. + grey matter layer + FMA:83142 + CNS gray matter layer + CNS grey matter layer + gray matter layer of neuraxis + grey matter layer of neuraxis + uberon + UBERON:0016548 + central nervous system gray matter layer + + + + + A layer of of the central nervous system that is part of gray matter. + + + + + + gray matter layer of neuraxis + FMA:83142 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + FMA:68861 + rexed lamina + uberon + UBERON:0016570 + lamina of gray matter of spinal cord + + + + + rexed lamina + FMA:68861 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Primordium that develops into the central nervous system + UBERON:3000469 + future CNS + presumptive central nervous system + uberon + UBERON:0016879 + future central nervous system + + + + + Primordium that develops into the central nervous system + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Primordium that develops into the nervous system + UBERON:3000477 + AAO:0000477 + presumptive nervous system + uberon + UBERON:0016880 + future nervous system + + + + + Primordium that develops into the nervous system + + + + + + presumptive nervous system + AAO:0000477 + + + + + + + + + + + + + + + + + + + + + + + + + + + The part of the conceptus that may be lost before birth or will be discarded at birth, or when the embryo becomes an independent organism. + AEO:0000195 + EHDAA2:0000003 + EMAPA:16042 + extra-embryonic component + extraembryonic component + uberon + UBERON:0016887 + entire extraembryonic component + + + + + + AEO + + + + + + + + + + + AEO + + + + + The part of the conceptus that may be lost before birth or will be discarded at birth, or when the embryo becomes an independent organism. + AEO:0000195 + AEO:JB + + + + + extraembryonic component + AEO:0000195 + + + + + + + + + An embryonic anatomical entity that will turn into one or more other anatomical entities, perhaps with other anatomical entities, later in development. + AEO:0000132 + uberon + UBERON:0016888 + transitional anatomical structure + + + + + + AEO + + + + + An embryonic anatomical entity that will turn into one or more other anatomical entities, perhaps with other anatomical entities, later in development. + AEO:0000132 + AEO:JB + + + + + + + + + + + + + + + + + + + + + + + + + + A mesenchyme-derived anatomical entity undergoing a transtion to become another structure. + AEO:0001016 + uberon + UBERON:0017650 + developing mesenchymal structure + + + + + A mesenchyme-derived anatomical entity undergoing a transtion to become another structure. + AEO:0001016 + AEO:JB + + + + + + + + + + + + + + + + + + + + + + + + + + + A zone of skin that is part of a lower lip. + + FMA:24767 + lower lip skin + uberon + UBERON:0018150 + skin of lower lip + + + + + A zone of skin that is part of a lower lip. + OBOL:automatic + + + + + lower lip skin + FMA:24767 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A boundary delimiting a rhombomere. + rhombomere junction + uberon + UBERON:0018239 + rhombomere boundary + + + + + A boundary delimiting a rhombomere. + GO:0021654 + + + + + + + + + + + + + + + + + + + + + + + + + + + Any portion of submucosa that lines the digestive tract. + uberon + UBERON:0018257 + submucosa of digestive tract + + + + + Any portion of submucosa that lines the digestive tract. + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any organ component layer that consists of muscle tissue. + NCITA class may refer to smooth muscle only + + FMA:45634 + NCIT:C75444 + uberon + UBERON:0018260 + layer of muscle tissue + + + + + Any organ component layer that consists of muscle tissue. + + + + + + NCITA class may refer to smooth muscle only + NCIT + + + + + + + + + + + + + + + + + + + + + + + + + + FMA:83450 + ventricular cardiac muscle tissue + ventricular heart muscle + uberon + ventricular muscle + UBERON:0018649 + cardiac muscle tissue of ventricle + + + + + ventricular cardiac muscle tissue + + + + + + ventricular heart muscle + + + + + + ventricular muscle + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An interconnected tubular multi-tissue structure that contains fluid that is actively transported around the heart. + FMA:73747 + ZFA:0005811 + cardiac vasculature + uberon + UBERON:0018674 + heart vasculature + + + + + An interconnected tubular multi-tissue structure that contains fluid that is actively transported around the heart. + ZFA:0005811 + ZFA:CVS + + + + + cardiac vasculature + FMA:73747 + + + + + + + + + + + + + + + + + + + + + + + + + + Any region of epithelium that is part of a skin region. + BTO:0004382 + uberon + UBERON:0019204 + skin epithelium + + + + + Any region of epithelium that is part of a skin region. + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The part of the eye that consists of both the retina and the optic choroid + + chorioretina + choroid and retina + retinachoroid + retinachoroidal region + uberon + UBERON:0019207 + + chorioretinal region + + + + + The part of the eye that consists of both the retina and the optic choroid + + UBERON:drseb + + + + + + + + + + + + + + + + + + + + + + + + + + DHBA:10654 + FMA:268630 + gray matter of the hindbrain + uberon + UBERON:0019263 + gray matter of hindbrain + + + + + gray matter of the hindbrain + DHBA:HGM + + + + + + + + + + + + + + + + + + + + + + + + + + DHBA:10157 + FMA:268608 + uberon + UBERON:0019264 + gray matter of forebrain + + + + + + + + + + + + + + + + + + + + + + + + + + DHBA:10649 + FMA:83913 + uberon + UBERON:0019267 + gray matter of midbrain + + + + + + + + + + + + + + + + + + + + + + + + + + FMA:83912 + uberon + UBERON:0019269 + gray matter of diencephalon + + + + + + + + + + + + + + + + + + + + + + + + + + EMAPA:35952 + MA:0003174 + uberon + UBERON:0019304 + sensory organ epithelium + + + + + + + + + + + + + + + + + + + + + An exocrine gland that is part of a integumental system. + integumental exocrine gland + integumental system exocrine gland + uberon + UBERON:0019319 + exocrine gland of integumental system + + + + + An exocrine gland that is part of a integumental system. + + GOC:dos + + + + + integumental exocrine gland + + + + + + integumental system exocrine gland + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + FMA:58315 + uberon + surface of region of wall of eyeball + UBERON:0022288 + surface of eyeball + + + + + surface of region of wall of eyeball + FMA:58315 + + + + + + + + + + + + + + + + Single layer of a laminar structure, identified by different density, arrangement or size of cells and processes arranged in flattened layers or lamina[CUMBO]. + this is currently used to group some cellular layers that may not strictly conform to the CARO definition of cell-part layer. Consider genericisizing and introducing subtypes for cellular layer, fibrous layer and cell soma layer + lamina + layer + NLX:149357 + uberon + UBERON:0022303 + + nervous system cell part layer + + + + + Single layer of a laminar structure, identified by different density, arrangement or size of cells and processes arranged in flattened layers or lamina[CUMBO]. + NLX:149357 + + + + + lamina + CUMBO:CUMBO + + + + + layer + CUMBO:CUMBO + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Serous membrane layer that is adjacent to and lines an organ. + FMA:15860 + visceral wall of serous membrane + uberon + UBERON:0022350 + visceral serous membrane + + + + + Serous membrane layer that is adjacent to and lines an organ. + + + + + + visceral wall of serous membrane + FMA:15860 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Serous membrane layer that lines to a body cavity. + cavity lining + FMA:15859 + MA:0002448 + parietal wall of serous membrane + uberon + UBERON:0022351 + parietal serous membrane + + + + + Serous membrane layer that lines to a body cavity. + + + + + + cavity lining + MA:0002448 + + + + + parietal wall of serous membrane + FMA:15859 + + + + + + + + + + + + + + + + An embryonic or larval epithelium that is committed to form part of the nervous system. + neurepithelium + AEO:0001008 + BTO:0000314 + EHDAA2_RETIRED:0004654 + FMA:64807 + embryonic neuroepithelium + neuroepithelium + uberon + UBERON:0034705 + developing neuroepithelium + + + + + An embryonic or larval epithelium that is committed to form part of the nervous system. + AEO:0001008 + AEO:JB + + + + + neurepithelium + BTO:0000314 + + + + + embryonic neuroepithelium + + + + + + neuroepithelium + AEO:0001008 + + + + + + + + + An epithelium that is undergoing proliferation to provide large numbers of neuronal cells. + AEO:0001009 + uberon + UBERON:0034706 + proliferating neuroepithelium + + + + + + AEO + + + + + An epithelium that is undergoing proliferation to provide large numbers of neuronal cells. + AEO:0001009 + + + + + + + + + A neuroepithelium some of whose cells are undergoing terminal differentiation to become neuronal cells. + AEO:0001010 + uberon + UBERON:0034707 + differentiating neuroepithelium + + + + + + AEO + + + + + A neuroepithelium some of whose cells are undergoing terminal differentiation to become neuronal cells. + AEO:0001010 + + + + + + + + + + + + + + + + + + + + + + + + + + + DHBA:12694 + EMAPA:32916 + marginal zone of hindbrain + uberon + MZH + UBERON:0034709 + hindbrain marginal layer + + + + + marginal zone of hindbrain + DHBA:12694 + + + + + MZH + DHBA:12694 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + EHDAA2:0001267 + EMAPA:17585 + spinal cord lateral wall ventricular layer + uberon + UBERON:0034710 + spinal cord ventricular layer + + + + + + + + + + + EHDAA2 + + + + + spinal cord lateral wall ventricular layer + EHDAA2:0001267 + + + + + + + + + The layer of the developing cerebral cortex that is formed from the first cohort of neurons to migrate out of the cortical ventricular zone; split by the second wave into marginal zone and subplate. + EMAPA:35261 + uberon + UBERON:0034711 + cortical preplate + + + + + The layer of the developing cerebral cortex that is formed from the first cohort of neurons to migrate out of the cortical ventricular zone; split by the second wave into marginal zone and subplate. + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + the area of axial mesoderm that develops into the prechordal plate + prechordal mesenchyme + uberon + UBERON:0034878 + prechordal mesoderm + + + + + the area of axial mesoderm that develops into the prechordal plate + MGI:anna + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + lumen of gland + uberon + UBERON:0034905 + gland lumen + + + + + + + + + + + + + + + An multicellular anatomical structure that has subparts of multiple organs as a part. + CARO:0020001 + uberon + anatomical cluster + UBERON:0034921 + multi organ part structure + + + + + + CARO + + + + + An multicellular anatomical structure that has subparts of multiple organs as a part. + CARO:0020001 + + + + + anatomical cluster + CARO:0020001 + + + + + + + + + + + + + + + A cluster of cells, largely surrounded by a morphological boundary. + CARO:0020002 + FMA:62807 + uberon + UBERON:0034922 + cell cluster + + + + + + CARO + + + + + A cluster of cells, largely surrounded by a morphological boundary. + CARO:0020002 + + + + + + + + + + + + + + + A collection of anatomical structures that are alike in terms of their morphology or developmental origin. + resolve if this should be a subclass of disconnected anatomical group. Some collections (e.g. the skeleton or skull) are arguably connected + uberon + UBERON:0034925 + anatomical collection + + + + + A collection of anatomical structures that are alike in terms of their morphology or developmental origin. + + + + + + + + + + + + + + + + + + + + + + + + + + + Any organ component layer that consists of smooth muscle tissue. + uberon + UBERON:0034933 + layer of smooth muscle tissue + + + + + Any organ component layer that consists of smooth muscle tissue. + + + + + + + + + + FMA:55268 + organ sector + organ zonal region + organ zone + uberon + organ region with floating fiat boundary + UBERON:0034944 + zone of organ + + + + + organ sector + FMA:55268 + + + + + organ zone + FMA:55268 + + + + + organ region with floating fiat boundary + FMA:55268 + + + + + + + + + + + + + + + + + + + + + + + + + + + NCIT:C25787 + uberon + duct epithelium + ductal epithelium + UBERON:0034969 + epithelial layer of duct + + + + + + + + + + + + + + + + + + + + + + + + + + DHBA:12682 + EMAPA:32917 + hindbrain mantle layer + uberon + UBERON:0034994 + hindbrain cortical intermediate zone + + + + + hindbrain mantle layer + EMAPA:32917 + + + + + + + + + + + + + + + + + + + + + + + + + + + Mesenchyme that is part of a developing jaw [Automatically generated definition]. + EMAPA:32907 + EMAPA:35454 + uberon + UBERON:0034995 + jaw mesenchyme + + + + + Mesenchyme that is part of a developing jaw [Automatically generated definition]. + OBOL:automatic + + + + + + + + + + + + + + + + + + + + + + + + + + EMAPA:32904 + MA:0003220 + uberon + UBERON:0035037 + jaw epithelium + + + + + + + + + + + + + + + + + + + + + + + + + + Any material entity that is located in the digestive tract. This includes undigested food and liquid as well as unexcreted waste products. It also includes other entities such as ingested stones used to aid digestion. Any microbial cells or cell populations are also included. + Note that we treat any material entity that is ingested as an anatomical structure by defintion, although this may be expanding the CARO usage somewhat + digestive tract contents + uberon + ingested material entity + UBERON:0035118 + material entity in digestive tract + + + + + Any material entity that is located in the digestive tract. This includes undigested food and liquid as well as unexcreted waste products. It also includes other entities such as ingested stones used to aid digestion. Any microbial cells or cell populations are also included. + + + + + + digestive tract contents + + + + + + + + + + + + + + + + + + + + + + + + + + + Anatomical surface, which is the external surface of the whole body. Examples: There is only one body surface. + + + FMA:61695 + NCIT:C29667 + surface of body + uberon + UBERON:0035159 + entire surface of organism + + + + + Anatomical surface, which is the external surface of the whole body. Examples: There is only one body surface. + FMA:61695 + + + + + surface of body + FMA:61695 + + + + + + + + + + + + + + + + + + + + + + + + + + + FMA:51797 + ciliary vein + uberon + UBERON:0035546 + uveal vein + + + + + ciliary vein + FMA:51797 + + + + + + + + + + + + + + + + + + + + + + + + + + The part of the circulatory system that lies within the subcutaneous tissue layers close to the surface of the skin. + FMA:225275 + superficial part of circulatory system + superficial vasculature + dermis vasculature + hypodermis vasculature + uberon + skin vasculature + subcutaneous vasculature + vasculature of skin + UBERON:0035549 + vasculature of integument + + + + + The part of the circulatory system that lies within the subcutaneous tissue layers close to the surface of the skin. + + + + + + vasculature of skin + FMA:225275 + + + + + + + + + + + + + + + + + + + + + + + + + + Any of the veins carrying deoxygenated blood from the subcutaneous tissue layers. + + + + FMA:76719 + NCIT:C33666 + uberon + superfical vein + superficial veins + superficial vessels + UBERON:0035550 + superficial vein + + + + + Any of the veins carrying deoxygenated blood from the subcutaneous tissue layers. + ncithesaurus:Superficial_Vein + + + + + superfical vein + + + + + + superficial veins + + + + + + superficial vessels + + + + + + + + + + + + + + + + + + + + + + + + + + + The part of the circulatory system that lies deep beneath the subcutaneous tissue layers away from the surface of the skin. + deep part of circulatory system + uberon + UBERON:0035551 + deep vasculature + + + + + The part of the circulatory system that lies deep beneath the subcutaneous tissue layers away from the surface of the skin. + + + + + + + + + + + + + + + + + + + + + + + + + + + A blood vessel carrying deoxygenated blood far beneath the skin usually accompanying an artery. + + + + FMA:76718 + NCIT:C32444 + uberon + deep veins + deep vessels + UBERON:0035552 + deep vein + + + + + A blood vessel carrying deoxygenated blood far beneath the skin usually accompanying an artery. + ncithesaurus:Deep_Vein + + + + + deep veins + + + + + + deep vessels + + + + + + + + + + + + + + + + The parts of the orbital region that are outside of the the eyeball, including the lacrimal apparatus, the extraocular muscles and the eyelids, eyelashes, eyebrows and the conjunctiva + + + + FMA:76554 + NCIT:C32574 + adnexa oculi + uberon + accessory parts of orbital region + accessory visual structures + accessory visual structures set + adnexal parts of orbital region + appendage of eye + appendages of the eye + eye adnexa + set of accessory visual structures + structurae oculi accessoriae + UBERON:0035639 + ocular adnexa + + + + + The parts of the orbital region that are outside of the the eyeball, including the lacrimal apparatus, the extraocular muscles and the eyelids, eyelashes, eyebrows and the conjunctiva + + + HPO:pr + UBERON:cjm + + + + + adnexa oculi + + + + + + + accessory visual structures + + + + + + accessory visual structures + FMA:76554 + + + + + accessory visual structures set + FMA:76554 + + + + + appendage of eye + + + + + + appendages of the eye + + + + + + + set of accessory visual structures + FMA:76554 + + + + + structurae oculi accessoriae + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + EHDAA2:0004181 + FMA:9464 + cardiac chamber cavity + heart cavity + heart lumen + uberon + UBERON:0035763 + cavity of cardiac chamber + + + + + + + + + + + FMA + + + + + cardiac chamber cavity + FMA:9464 + + + + + heart cavity + FMA:9464 + + + + + heart lumen + EHDAA2:0004181 + + + + + + + + + + + + + + + + + + + + + + + + + + + + The primordial mouth region of the developing head. + FMA:293105 + primitive mouth + primordial mouth + uberon + UBERON:0035804 + future mouth + + + + + The primordial mouth region of the developing head. + MP:0003119 + + + + + primitive mouth + FMA:293105 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + FMA:12241 + uberon + UBERON:0035809 + serous cavity + + + + + + + + + + + + + + + + + + + + + + + + + + The sum of epicardial and paracardial fat deposits. + + ZFA:0005765 + uberon + UBERON:0035814 + pericardial fat + + + + + The sum of epicardial and paracardial fat deposits. + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Fat deposits in the mediastinum outside the parietal pericardium . + intrathoracic fat + uberon + UBERON:0035815 + paracardial fat + + + + + Fat deposits in the mediastinum outside the parietal pericardium . + + + + + + intrathoracic fat + + + + + + + + + + + + + + + + + + + + + + + + + + + Any fat deposit surrounding a visceral organ. + uberon + UBERON:0035818 + visceral fat + + + + + Any fat deposit surrounding a visceral organ. + UBERON:cjm + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + BTO:0004378 + EMAPA:37987 + FMA:67473 + blood vessel wall + uberon + vascular wall + UBERON:0035965 + wall of blood vessel + + + + + EMAPA:37987 + MA:th + + + + + blood vessel wall + FMA:67473 + + + + + vascular wall + BTO:0004378 + + + + + + + + + + + + An region of the mesoderm that includes anterior lateral mesoderm of the first heart field plus contiguous pharyngeal mesoderm that gives rise to second-heart-field-derived regions of the heart and branchiomeric muscles. + uberon + UBERON:0036146 + cardiopharyngeal field + + + + + An region of the mesoderm that includes anterior lateral mesoderm of the first heart field plus contiguous pharyngeal mesoderm that gives rise to second-heart-field-derived regions of the heart and branchiomeric muscles. + + BGEE:ann + + + + + + + + + + + + + + + + + + + + + Material anatomical entity that forms the outermost boundary of an anatomical structure. + AAO:0010270 + AEO:0000154 + ZFA:0005594 + uberon + UBERON:0036215 + anatomical surface region + + + + + Material anatomical entity that forms the outermost boundary of an anatomical structure. + + + + + + + + + + + + + + + + + + + + + + + + + + + A bodily fluid that is located in the coelom. + he coelomic fluid serves several functions; it acts as a hydroskeleton, it allows free movement and growth of internal organs, it serves for transport of gases, nutrients and waste products between different parts of the body, it allows storage of sperm and eggs during maturation and it acts as a reservoir for waste [Wikipedia:Coelom#Coelomic_fluid] + BTO:0001708 + uberon + UBERON:0036217 + coelomic fluid + + + + + A bodily fluid that is located in the coelom. + + + + + + + + + + + + + + + + + + + + + + + + + + + + Any gland that is part os the respiratory system. + uberon + UBERON:0036225 + respiratory system gland + + + + + Any gland that is part os the respiratory system. + UBERON:cjm + + + + + + + + + + + + + + + + + + + + + + + + + + A notochord that has persisted beyond the embryonic stage. + + + + + + uberon + UBERON:0036242 + post-embryonic notochord + + + + + A notochord that has persisted beyond the embryonic stage. + UBERON:cjm + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A transudate found in the serous sac. + serous fluid + FMA:20932 + serous sac fluid + uberon + UBERON:0036244 + secretion of serous membrane + + + + + A transudate found in the serous sac. + FMA:20932 + + + + + serous fluid + FMA:20932 + + + + + + + + + + + + + + + + + + + + + + + + + + FMA:53133 + cranial orifice + skull orifice + uberon + UBERON:0036253 + orifice of skull + + + + + cranial orifice + FMA:53133 + + + + + skull orifice + FMA:53133 + + + + + + + + + + + + + + + + + + + + + + + + + + + A mucosa that is part of a lip region [Automatically generated definition]. + NCIT:C12226 + labial mucosa + uberon + UBERON:0036294 + mucosa of lip + + + + + A mucosa that is part of a lip region [Automatically generated definition]. + OBOL:automatic + + + + + labial mucosa + UBERON:cjm + + + + + + + + + + + + + + + + + uberon + UBERON:0036302 + vasculature of central nervous system plus retina + + + + + + + + + + + + + + + + + + + + + + + + + + + FMA:259905 + uberon + UBERON:0036303 + vasculature of central nervous system + + + + + + + + + + + + + + + + + + + + + + + + + + + FMA:58098 + eyeball wall + uberon + UBERON:0036925 + wall of eyeball + + + + + + FMA + + + + + + + + + + + FMA + + + + + eyeball wall + FMA:58098 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + wall of organ which has as its parts the endocardium, myocardium , epicardium, and the cardiac septum, surrounded by the pericardial sac proper and is continuous with the walls of the systemic and pulmonary arterial and venous trees. + FMA:7274 + cardiac wall + uberon + UBERON:0037144 + wall of heart + + + + + + FMA + + + + + + + + + + + FMA + + + + + + + + + + + FMA + + + + + + + + + + + FMA + + + + + wall of organ which has as its parts the endocardium, myocardium , epicardium, and the cardiac septum, surrounded by the pericardial sac proper and is continuous with the walls of the systemic and pulmonary arterial and venous trees. + FMA:7274 + + + + + cardiac wall + FMA:7274 + + + + + + + + - + - - + + - + - - + + - A quality of an object that has a value that is normal or average. - Luke Slater - 2017-12-21T14:11:01Z - quality - PATO:0045001 - normal object quality + A zone of skin that is part of the face. + + + eriks + 2012-02-05T05:23:01Z + + + EMAPA:36657 + FMA:24758 + NCIT:C33561 + UMLS:C0222084 + face skin + uberon + facial skin + UBERON:1000021 + + + skin of face + + + + A zone of skin that is part of the face. + + UBERON:EJS + + + + + UMLS:C0222084 + ncithesaurus:Skin_of_the_Face + + + + + face skin + EMAPA:36657 + FMA:24758 + - + - + - + - - + + - - - An affinity which is relatively normal or average. - Luke Slater - 2017-12-22T14:16:43Z - quality - PATO:0045004 - - normal affinity + + + + + + + + An anatomical junction between two parts of the digestive tract. + + 2021-02-05T11:19:31Z + uberon + UBERON:1100000 + digestive tract junction + + + + An anatomical junction between two parts of the digestive tract. + ORCID:0000-0002-7073-9172 + - + - + - + - - + + - - - A curvature which is relatively normal or average. - Luke Slater - 2017-12-22T14:16:43Z - quality - PATO:0045013 - - normal curvature + + + + + + + + Structures of the dermis, epidermis, glands and pigment cells recognizable on the external surfaces of the integument. + This class was sourced from an external ontology (amphibian_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon + amphibian_anatomy_curators + uberon/phenoscape-anatomy + Not clear how this differs from parent class. See https://github.com/obophenotype/uberon/issues/1305 + external integument structure + + + + Structures of the dermis, epidermis, glands and pigment cells recognizable on the external surfaces of the integument. + AAO:EJS + - + - + - + - - + + - - - A life span which is relatively normal or average. - Luke Slater - 2017-12-22T14:16:43Z - quality - PATO:0045026 - normal life span + + + + + + + + Dermal, epidermal, glandular and pigment structures of the external head integument. + This class was sourced from an external ontology (amphibian_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon + amphibian_anatomy_curators + uberon/phenoscape-anatomy + head external integument structure + + + + Dermal, epidermal, glandular and pigment structures of the external head integument. + AAO:EJS + - + - + - + - - + + - - - A size quality which is relatively normal or average - Luke Slater - 2017-12-22T14:16:43Z - quality - PATO:0045050 - - normal size + + + + + + + + Dermal, epidermal, glandular and pigment structures of the body integument. + This class was sourced from an external ontology (amphibian_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon + amphibian_anatomy_curators + uberon/phenoscape-anatomy + body external integument structure + + + + + Dermal, epidermal, glandular and pigment structures of the body integument. + AAO:EJS + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Blood vessels in respiratory skin. + Modified from the original AAO source + amphibian_anatomy_curators + uberon/phenoscape-anatomy + vasculature of respiratory integument + + + + Blood vessels in respiratory skin. + AAO:EJS + @@ -5265,66 +65772,182 @@ For example, A and B may be gene products and binding of B by A positively regul - - + + + + + + + + + + + + + + 2 + + + + + + + + + + + + + + + + + + + + + 1 + + + + + + + + + + + + + + + + + + + + + 2 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - - + + - + + + + + - - - - - - 2 - - - - + + + + - - + - - + + - + + + + + - - - - - - 1 - - - - + + + + - - + - - + + - + + + + + - - - - - - 2 - - - - + + + + @@ -5357,6 +65980,61 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + @@ -5390,6 +66068,77 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + @@ -5518,8 +66267,8 @@ For example, A and B may be gene products and binding of B by A positively regul true - MF(X)-directly_regulates->MF(Y)-enabled_by->GP(Z) => MF(Y)-has_input->GP(Y) e.g. if 'protein kinase activity'(X) directly_regulates 'protein binding activity (Y)and this is enabled by GP(Z) then X has_input Z - infer input from direct reg + MF(X)-directly_regulates->MF(Y)-enabled_by->GP(Z) => MF(Y)-has_input->GP(Y) e.g. if 'protein kinase activity'(X) directly_regulates 'protein binding activity (Y)and this is enabled by GP(Z) then X has_input Z + infer input from direct reg @@ -5648,8 +66397,8 @@ e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase true - GP(X)-enables->MF(Y)-part_of->BP(Z) => GP(X) involved_in BP(Z) e.g. if X enables 'protein kinase activity' and Y 'part of' 'signal tranduction' then X involved in 'signal transduction' - involved in BP + GP(X)-enables->MF(Y)-part_of->BP(Z) => GP(X) involved_in BP(Z) e.g. if X enables 'protein kinase activity' and Y 'part of' 'signal tranduction' then X involved in 'signal transduction' + involved in BP @@ -6219,6 +66968,118 @@ e.g. if GP X enables ATPase coupled transporter activity' and 'ATPase + + 'causally downstream of' and 'overlaps' should be disjoint properties (a SWRL rule is required because these are non-simple properties). + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + 'causally upstream of' and 'overlaps' should be disjoint properties (a SWRL rule is required because these are non-simple properties). + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + diff --git a/imports/pr_import.owl b/imports/pr_import.owl index e0b71fcba..ac46884fd 100644 --- a/imports/pr_import.owl +++ b/imports/pr_import.owl @@ -9,8 +9,8 @@ xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"> - - 2021-02-01 + + 2021-06-28 @@ -513,7 +513,7 @@ molecular function molecular_function GO:0003674 - Note that, in addition to forming the root of the molecular function ontology, this term is recommended for use for the annotation of gene products whose molecular function is unknown. When this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code "no data" (ND), is used to indicate this. Despite its name, this is not a type of 'function' in the sense typically defined by upper ontologies such as Basic Formal Ontology (BFO). It is instead a BFO:process carried out by a single gene product or complex. + Note that, in addition to forming the root of the molecular function ontology, this term is recommended for use for the annotation of gene products whose molecular function is unknown. When this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. Despite its name, this is not a type of 'function' in the sense typically defined by upper ontologies such as Basic Formal Ontology (BFO). It is instead a BFO:process carried out by a single gene product or complex. molecular_function @@ -607,6 +607,24 @@ + + + + + A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. + cellular_component + GO:0005634 + nucleus + + + + + A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. + GOC:go_curators + + + + @@ -652,7 +670,7 @@ biological process biological_process GO:0008150 - Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code "no data" (ND), is used to indicate this. + Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. biological_process @@ -685,6 +703,33 @@ + + + + + Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. + ionotropic receptor activity + molecular_function + GO:0015276 + ligand-gated ion channel activity + + + + + Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. + GOC:mtg_transport + ISBN:0815340729 + + + + + ionotropic receptor activity + GOC:bf + GOC:sart + + + + @@ -710,6 +755,7 @@ + Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or carbohydrate groups. protein-protein complex cellular_component @@ -1035,6 +1081,24 @@ + + + + + cat + ncbi_taxonomy + NCBITaxon:9685 + Felis catus + + + + + cat + + + + + @@ -1059,6 +1123,7 @@ obi OBI:0100026 + Category=external. organism @@ -1536,22 +1601,23 @@ - A receptor-type tyrosine-protein phosphatase C that is a translation product of a mature transcript of the PTPRC gene, that includes the region encoded by the variable exons 4(A), 5(B), and 6(C). Example: UniProtKB:P08575-3. + A receptor-type tyrosine-protein phosphatase C that is a translation product of some mRNA giving rise to a protein with the amino acid sequence represented by UniProtKB:P08575-3 or a 1:1 ortholog thereof. CD45RABC PTPRC/iso:CD45RABC protein B220 CD45R PR:000001014 - Category=sequence. Requested by=CL. + Category=sequence. Requested by=CL. Note: This isoform includes the region encoded by the variable exons 4(A), 5(B), and 6(C). receptor-type tyrosine-protein phosphatase C isoform CD45RABC - A receptor-type tyrosine-protein phosphatase C that is a translation product of a mature transcript of the PTPRC gene, that includes the region encoded by the variable exons 4(A), 5(B), and 6(C). Example: UniProtKB:P08575-3. + A receptor-type tyrosine-protein phosphatase C that is a translation product of some mRNA giving rise to a protein with the amino acid sequence represented by UniProtKB:P08575-3 or a 1:1 ortholog thereof. PMID:1351092 PRO:CNA + PRO:DAN @@ -1567,20 +1633,21 @@ - A receptor-type tyrosine-protein phosphatase C isoform CD45R that is a translation product of a mature transcript of the PTPRC gene, that includes the region encoded by the variable exon 4(A), and lacks the region encoded by exons 5(B) and 6(C). + A receptor-type tyrosine-protein phosphatase C isoform CD45R that is a translation product of some mRNA giving rise to a protein with the amino acid sequence represented by UniProtKB:P08575-8 or a 1:1 ortholog thereof. CD45RA PTPRC/iso:CD45RA protein PR:000001015 - Category=sequence. Requested by=CL. + Category=sequence. Requested by=CL. Note: This isoform includes the region encoded by the variable exon 4(A), and lacks the region encoded by exons 5(B) and 6(C). receptor-type tyrosine-protein phosphatase C isoform CD45RA - A receptor-type tyrosine-protein phosphatase C isoform CD45R that is a translation product of a mature transcript of the PTPRC gene, that includes the region encoded by the variable exon 4(A), and lacks the region encoded by exons 5(B) and 6(C). + A receptor-type tyrosine-protein phosphatase C isoform CD45R that is a translation product of some mRNA giving rise to a protein with the amino acid sequence represented by UniProtKB:P08575-8 or a 1:1 ortholog thereof. PMID:1351092 PRO:CNA + PRO:DAN @@ -1596,22 +1663,23 @@ - A receptor-type tyrosine-protein phosphatase C that is a translation product of a mature transcript of the PTPRC gene, that lacks the region encoded by the variable exons 4(A), 5(B), and 6(C). Example: UniProtKB:P08575-4. + A receptor-type tyrosine-protein phosphatase C that is a translation product of some mRNA giving rise to a protein with the amino acid sequence represented by UniProtKB:P08575-4 or a 1:1 ortholog thereof. 180 kDa form CD45RO PTPRC/iso:CD45RO protein T200 PR:000001017 - Category=sequence. Requested by=CL. + Category=sequence. Requested by=CL. Note: This isoform lacks the region encoded by the variable exons 4(A), 5(B), and 6(C). receptor-type tyrosine-protein phosphatase C isoform CD45RO - A receptor-type tyrosine-protein phosphatase C that is a translation product of a mature transcript of the PTPRC gene, that lacks the region encoded by the variable exons 4(A), 5(B), and 6(C). Example: UniProtKB:P08575-4. + A receptor-type tyrosine-protein phosphatase C that is a translation product of some mRNA giving rise to a protein with the amino acid sequence represented by UniProtKB:P08575-4 or a 1:1 ortholog thereof. PMID:1351092 PRO:CNA + PRO:DAN @@ -1883,21 +1951,6 @@ Category=gene. Requested by=CL. T-cell surface glycoprotein CD8 alpha chain - - - - A protein that is a translation product of the human CD8A gene or a 1:1 ortholog thereof. CD8 is a transmembrane that is a co-receptor for MHC class-I antigen/T-cell receptor interaction. The most common form of CD8 is composed of a CD8 alpha and a CD8 beta chain. - PMID:11114424 - PRO:CNA - Wikipedia:CD8 - - - - - CD8A - PRO:DNx - - @@ -1916,6 +1969,21 @@ MAL + + + + A protein that is a translation product of the human CD8A gene or a 1:1 ortholog thereof. CD8 is a transmembrane that is a co-receptor for MHC class-I antigen/T-cell receptor interaction. The most common form of CD8 is composed of a CD8 alpha and a CD8 beta chain. + PMID:11114424 + PRO:CNA + Wikipedia:CD8 + + + + + CD8A + PRO:DNx + + @@ -1938,6 +2006,13 @@ Category=gene. T-cell surface glycoprotein CD8 beta chain + + + + A protein that is a translation product of the human CD8B gene or a 1:1 ortholog thereof. CD8 is a transmembrane receptor that is a co-receptor for MHC class-I antigen/T-cell receptor interaction. The most common form of CD8 is composed of a CD8 alpha and a CD8 beta chain. + PRO:CNA + Wikipedia:CD8 + @@ -1969,13 +2044,6 @@ Lyt3 - - - - A protein that is a translation product of the human CD8B gene or a 1:1 ortholog thereof. CD8 is a transmembrane receptor that is a co-receptor for MHC class-I antigen/T-cell receptor interaction. The most common form of CD8 is composed of a CD8 alpha and a CD8 beta chain. - PRO:CNA - Wikipedia:CD8 - @@ -3790,18 +3858,18 @@ - A protein with a core domain architecture consisting of an extracellular domain containing two or three copies of the Immunoglobulin domain (Pfam:PF00047), followed by a single-pass transmembrane region and a small intracellular domain. The active protein is a low affinity receptor for immunoglobulin gamma chain Fc region. It comprises the translation products of the FCGR1 gene (mouse) or one of the closely related FCGR1A, FCGR1B, or FCGR1C genes (human). FCGR1C may be a pseudogene in human. + A protein with a core domain architecture consisting of an extracellular domain containing two or three copies of the Immunoglobulin domain (Pfam:PF00047), followed by a single-pass transmembrane region and a small intracellular domain. PIRSF:PIRSF001981 protein Fc-gamma receptor PR:000001356 - Category=family. + Category=family. Note: The active protein is a low affinity receptor for immunoglobulin gamma chain Fc region. It comprises the translation products of the FCGR1 gene (mouse) or one of the closely related FCGR1A, FCGR1B, or FCGR1C genes (human). FCGR1C may be a pseudogene in human. immunoglobulin gamma Fc receptor I - A protein with a core domain architecture consisting of an extracellular domain containing two or three copies of the Immunoglobulin domain (Pfam:PF00047), followed by a single-pass transmembrane region and a small intracellular domain. The active protein is a low affinity receptor for immunoglobulin gamma chain Fc region. It comprises the translation products of the FCGR1 gene (mouse) or one of the closely related FCGR1A, FCGR1B, or FCGR1C genes (human). FCGR1C may be a pseudogene in human. + A protein with a core domain architecture consisting of an extracellular domain containing two or three copies of the Immunoglobulin domain (Pfam:PF00047), followed by a single-pass transmembrane region and a small intracellular domain. PRO:CNA @@ -6413,7 +6481,6 @@ OB-BP2 OB-binding protein 2 SIGLEC5 - mSiglec-F obesity-binding protein 2 sialic acid-binding Ig-like lectin F siglec-5 @@ -7302,6 +7369,57 @@ + + + + + A CSF-1/PDGF receptor-type tyrosine-protein kinase that is a translation product of the human PDGFRA gene or a 1:1 ortholog thereof. + IUPHARobj:1803 + PANTHER:PTHR24416:SF207 + PIRSF:PIRSF500950 + CD140 antigen-like family member A + CD140a + CD140a antigen + PDGF-R-alpha + PDGFR-alpha + PDGFRA + alpha platelet-derived growth factor receptor + platelet-derived growth factor alpha receptor + protein + PDGFR2 + RHEPDGFRA + PR:000002030 + Category=gene. + alpha-type platelet-derived growth factor receptor + + + + + A CSF-1/PDGF receptor-type tyrosine-protein kinase that is a translation product of the human PDGFRA gene or a 1:1 ortholog thereof. + PRO:WCB + + + + + PDGFRA + PRO:DNx + + + + + + PDGFR2 + + + + + + RHEPDGFRA + + + + + @@ -7967,6 +8085,82 @@ + + + + + A protein that is a component of collagen. Collagens are trimeric molecules in which each chain comprises a repeating Gly-X-Y triplet, in which X and Y can be any residue but are usually proline and hydroxyproline, respectively. This results in a left-handed helix that combines with other two to form a triple-helical structure. + protein + PR:000003262 + Category=family. + collagen alpha chain + + + + + A protein that is a component of collagen. Collagens are trimeric molecules in which each chain comprises a repeating Gly-X-Y triplet, in which X and Y can be any residue but are usually proline and hydroxyproline, respectively. This results in a left-handed helix that combines with other two to form a triple-helical structure. + PMID:15788652 + PMID:1639194 + Pfam:PF01391 + + + + + + + + + A collagen alpha chain that is a translation product of the human COL1A1 or COL1A2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. + protein + PR:000003263 + Category=family. + collagen type I alpha chain + + + + + A collagen alpha chain that is a translation product of the human COL1A1 or COL1A2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. + PRO:CNA + PRO:DAN + + + + + + + + + A collagen type I alpha chain that is a translation product of the human COL1A1 gene or a 1:1 ortholog thereof. + COL1A1 + alpha-1 type I collagen + protein + Cola1 + PR:000003264 + Category=gene. + collagen alpha-1(I) chain + + + + + A collagen type I alpha chain that is a translation product of the human COL1A1 gene or a 1:1 ortholog thereof. + PRO:CNA + + + + + COL1A1 + PRO:DNx + + + + + + Cola1 + + + + + @@ -8417,6 +8611,33 @@ + + + + + A protein that is a translation product of the human CCK gene or a 1:1 ortholog thereof. + CCK + protein + PR:000005110 + Category=gene. + cholecystokinin + + + + + A protein that is a translation product of the human CCK gene or a 1:1 ortholog thereof. + PRO:DNx + + + + + CCK + PRO:DNx + + + + + @@ -8550,6 +8771,48 @@ + + + + + A nicotinic acetylcholine receptor protein that is a translation product of the human CHRNA7 gene or a 1:1 ortholog thereof. + IUPHARobj:468 + CHRNA7 + protein + Acra7 + NACHRA7 + PR:000005460 + Category=gene. + neuronal acetylcholine receptor subunit alpha-7 + + + + + A nicotinic acetylcholine receptor protein that is a translation product of the human CHRNA7 gene or a 1:1 ortholog thereof. + PRO:DNx + + + + + CHRNA7 + PRO:DNx + + + + + + Acra7 + + + + + + NACHRA7 + + + + + @@ -9642,6 +9905,98 @@ + + + + + A protein that is a translation product of the human LUM gene or a 1:1 ortholog thereof. + KSPG lumican + LUM + keratan sulfate proteoglycan lumican + protein + LDC + Lcn + SLRR2D + PR:000009981 + Category=gene. + lumican + + + + + A protein that is a translation product of the human LUM gene or a 1:1 ortholog thereof. + PRO:DNx + + + + + LUM + PRO:DNx + + + + + + LDC + + + + + + Lcn + + + + + + SLRR2D + + + + + + + + + + A protein that is a translation product of the human MEIS2 gene or a 1:1 ortholog thereof. + MEIS2 + Meis1-related protein 1 + protein + MRG1 + Stra10 + PR:000010317 + Category=gene. + homeobox protein Meis2 + + + + + A protein that is a translation product of the human MEIS2 gene or a 1:1 ortholog thereof. + PRO:DNx + + + + + MEIS2 + PRO:DNx + + + + + + MRG1 + + + + + + Stra10 + + + + + @@ -9903,6 +10258,40 @@ + + + + + A protein that is a translation product of the human PVALB gene or a 1:1 ortholog thereof. + PVALB + protein + Pva + PR:000013502 + Category=gene. + parvalbumin alpha + + + + + A protein that is a translation product of the human PVALB gene or a 1:1 ortholog thereof. + PRO:DNx + + + + + PVALB + PRO:DNx + + + + + + Pva + + + + + @@ -10046,6 +10435,93 @@ + + + + + A protein that is a translation product of the human SNCG gene or a 1:1 ortholog thereof. + SNCG + SR + breast cancer-specific gene 1 protein + persyn + synoretin + protein + BCSG1 + PERSYN + PRSN + PR:000015325 + Category=gene. + gamma-synuclein + + + + + A protein that is a translation product of the human SNCG gene or a 1:1 ortholog thereof. + PRO:DNx + + + + + SNCG + PRO:DNx + + + + + + BCSG1 + + + + + + PERSYN + + + + + + PRSN + + + + + + + + + + A protein that is a translation product of the human SST gene or a 1:1 ortholog thereof. + SST + growth hormone release-inhibiting factor + protein + Smst + PR:000015665 + Category=gene. + somatostatin + + + + + A protein that is a translation product of the human SST gene or a 1:1 ortholog thereof. + PRO:DNx + + + + + SST + PRO:DNx + + + + + + Smst + + + + + @@ -10144,6 +10620,48 @@ + + + + + A protein that is a translation product of the human VIP gene or a 1:1 ortholog thereof. + VIP + vasoactive intestinal peptides + vasoactive intestinal polypeptides + vasoactive intestinal polypeptides precursor + protein + PR:000017299 + Category=gene. + VIP peptides + + + + + A protein that is a translation product of the human VIP gene or a 1:1 ortholog thereof. + PRO:DNx + + + + + VIP + PRO:DNx + + + + + + vasoactive intestinal peptides + PRO:DNx + + + + + vasoactive intestinal polypeptides + PRO:DNx + + + + @@ -12259,6 +12777,50 @@ + + + + + + + + + + + + + + + + + + + + + + An alpha-type platelet-derived growth factor receptor that has had the signal peptide removed. + PDGFRA/SigPep- + protein + PR:000018697 + Category=modification. + alpha-type platelet-derived growth factor receptor, signal peptide removed form + + + + + An alpha-type platelet-derived growth factor receptor that has had the signal peptide removed. + PRO:DNx + + + + + PDGFRA/SigPep- + PRO:DNx + + + + + @@ -12435,6 +12997,50 @@ + + + + + + + + + + + + + + + + + + + + + + A collagen alpha-1(I) chain that has had the signal peptide removed. + COL1A1/SigPep- + protein + PR:000018797 + Category=modification. + collagen alpha-1(I) chain, signal peptide removed form + + + + + A collagen alpha-1(I) chain that has had the signal peptide removed. + PRO:DNx + + + + + COL1A1/SigPep- + PRO:DNx + + + + + @@ -12479,6 +13085,50 @@ + + + + + + + + + + + + + + + + + + + + + + A cholecystokinin that has had the signal peptide removed. + CCK/SigPep- + protein + PR:000019254 + Category=modification. + cholecystokinin, signal peptide removed form + + + + + A cholecystokinin that has had the signal peptide removed. + PRO:DNx + + + + + CCK/SigPep- + PRO:DNx + + + + + @@ -12831,6 +13481,50 @@ + + + + + + + + + + + + + + + + + + + + + + A lumican that has had the signal peptide removed. + LUM/SigPep- + protein + PR:000020499 + Category=modification. + lumican, signal peptide removed form + + + + + A lumican that has had the signal peptide removed. + PRO:DNx + + + + + LUM/SigPep- + PRO:DNx + + + + + @@ -13051,6 +13745,50 @@ + + + + + + + + + + + + + + + + + + + + + + A somatostatin that has had the signal peptide removed. + SST/SigPep- + protein + PR:000021577 + Category=modification. + somatostatin, signal peptide removed form + + + + + A somatostatin that has had the signal peptide removed. + PRO:DNx + + + + + SST/SigPep- + PRO:DNx + + + + + @@ -14546,6 +15284,45 @@ + + + + + A protein that is a translation product of the human LAMP5 gene or a 1:1 ortholog thereof. + BAD-LAMP + LAMP-5 + LAMP5 + brain and dendritic cell-associated LAMP + brain-associated LAMP-like protein + lysosome-associated membrane protein 5 + protein + C20orf103 + PR:000032148 + Category=gene. + lysosome-associated membrane glycoprotein 5 + + + + + A protein that is a translation product of the human LAMP5 gene or a 1:1 ortholog thereof. + PRO:DNx + + + + + LAMP5 + PRO:DNx + + + + + + C20orf103 + + + + + @@ -14833,6 +15610,118 @@ + + + + + + + + + + + + + + + + + + + + + + A neuronal acetylcholine receptor subunit alpha-7 that has had the signal peptide removed. + CHRNA7/SigPep- + protein + PR:000044062 + Category=modification. + neuronal acetylcholine receptor subunit alpha-7, signal peptide removed form + + + + + A neuronal acetylcholine receptor subunit alpha-7 that has had the signal peptide removed. + PRO:DAN + + + + + CHRNA7/SigPep- + PRO:DAN + + + + + + + + + + + + + + + + + + + + + + + + + + + + A neuronal acetylcholine receptor subunit alpha-7, signal peptide removed form in human. Example: UniProtKB:P36544-1, 23-502. + Reactome:R-HSA-507830 + hCHRNA7/SigPep- + PRO_0000000366 + UniProtKB:P36544-1, 23-502 + protein + PR:000044063 + Category=organism-modification. + neuronal acetylcholine receptor subunit alpha-7, signal peptide removed form (human) + + + + + A neuronal acetylcholine receptor subunit alpha-7, signal peptide removed form in human. Example: UniProtKB:P36544-1, 23-502. + PRO:DAN + + + + + Reactome:R-HSA-507830 + PR:000044063 located_in GO:0005886 + + + + + hCHRNA7/SigPep- + PRO:DAN + + + + + + PRO_0000000366 + PRO:DNx + + + + + + UniProtKB:P36544-1, 23-502 + PRO:DNx + + + + + @@ -14907,6 +15796,71 @@ + + + + + A ligand-gated ion channel protein that is a translation product of the human CHRNA1-7, CHRNA9-10, CHRNB1-4, CHRNG, CHRND, or CHRNE genes, 1:1 orthologs thereof, or a semi-ortholog thereof. + IUPHARfam:76 + protein + PR:000044668 + Category=family. + nicotinic acetylcholine receptor protein + + + + + A ligand-gated ion channel protein that is a translation product of the human CHRNA1-7, CHRNA9-10, CHRNB1-4, CHRNG, CHRND, or CHRNE genes, 1:1 orthologs thereof, or a semi-ortholog thereof. + PRO:XQ + + + + + + + + + + + + + + + + + + + + + + + + + + An ion channel protein that has ligand-gated ion channel activity. The ligand-gated ion channel opens when a specific ligand has been bound by the channel complex or one of its constituent parts. + IUPHARfam:697 + ionotropic receptor + protein + PR:000044671 + Category=family. + ligand-gated ion channel protein + + + + + An ion channel protein that has ligand-gated ion channel activity. The ligand-gated ion channel opens when a specific ligand has been bound by the channel complex or one of its constituent parts. + GO:0015276 + PRO:XQ + + + + + ionotropic receptor + PRO:XQ + + + + @@ -15082,6 +16036,81 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A cholecystokinin (human) that has had the signal peptide removed. UniProtKB:P06307, 21-115. + Reactome:R-HSA-388539 + PRO_0000010536 + UniProtKB:P06307, 21-115 + hCCK/SigPep- + protein + PR:000046582 + Category=organism-modification. + cholecystokinin, signal peptide removed form (human) + + + + + A cholecystokinin (human) that has had the signal peptide removed. UniProtKB:P06307, 21-115. + PRO:DNx + Reactome:R-HSA-388539 + + + + + Reactome:R-HSA-388539 + PR:000046582 located_in GO:0005576 + + + + + PRO_0000010536 + PRO:DNx + + + + + + UniProtKB:P06307, 21-115 + PRO:DNx + + + + + + hCCK/SigPep- + PRO:DNx + + + + + @@ -16462,6 +17491,81 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A collagen alpha-1(I) chain (human) that has had the signal peptide removed. UniProtKB:P02452, 23-1464. + Reactome:R-HSA-1650777 + Reactome:R-HSA-2268635 + UniProtKB:P02452, 23-1464 + hCOL1A1/SigPep- + protein + PR:000046823 + Category=organism-modification. + collagen alpha-1(I) chain, signal peptide removed form (human) + + + + + A collagen alpha-1(I) chain (human) that has had the signal peptide removed. UniProtKB:P02452, 23-1464. + PRO:DNx + Reactome:R-HSA-1650777 + Reactome:R-HSA-2268635 + + + + + Reactome:R-HSA-1650777 + PR:000046823 located_in GO:0005788 + + + + + Reactome:R-HSA-2268635 + PR:000046823 located_in GO:0005576 + + + + + UniProtKB:P02452, 23-1464 + PRO:DNx + + + + + + hCOL1A1/SigPep- + PRO:DNx + + + + + @@ -18205,6 +19309,81 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A lumican (human) that has had the signal peptide removed. UniProtKB:P51884, 19-338. + Reactome:R-HSA-2466189 + PRO_0000032733 + UniProtKB:P51884, 19-338 + hLUM/SigPep- + protein + PR:000048273 + Category=organism-modification. + lumican, signal peptide removed form (human) + + + + + A lumican (human) that has had the signal peptide removed. UniProtKB:P51884, 19-338. + PRO:DNx + Reactome:R-HSA-2466189 + + + + + Reactome:R-HSA-2466189 + PR:000048273 located_in GO:0005576 + + + + + PRO_0000032733 + PRO:DNx + + + + + + UniProtKB:P51884, 19-338 + PRO:DNx + + + + + + hLUM/SigPep- + PRO:DNx + + + + + @@ -18666,6 +19845,81 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A platelet-derived growth factor receptor alpha (human) that has had the signal peptide removed. UniProtKB:P16234, 24-1089. + Reactome:R-HSA-186794 + PRO_0000016760 + UniProtKB:P16234, 24-1089 + hPDGFRA/SigPep- + protein + PR:000048723 + Category=organism-modification. + platelet-derived growth factor receptor alpha, signal peptide removed form (human) + + + + + A platelet-derived growth factor receptor alpha (human) that has had the signal peptide removed. UniProtKB:P16234, 24-1089. + PRO:DNx + Reactome:R-HSA-186794 + + + + + Reactome:R-HSA-186794 + PR:000048723 located_in GO:0005886 + + + + + PRO_0000016760 + PRO:DNx + + + + + + UniProtKB:P16234, 24-1089 + PRO:DNx + + + + + + hPDGFRA/SigPep- + PRO:DNx + + + + + @@ -19968,7 +21222,7 @@ - A receptor-type tyrosine-protein phosphatase C that is a translation product of a mature transcript of the PTPRC gene, that minimally includes the region encoded by the variable exon 4(A). + A receptor-type tyrosine-protein phosphatase C that is a translation product of a transcript that minimally includes the region encoded by the variable exon 4(A). CD45R PTPRC/iso:CD45R protein @@ -19979,7 +21233,7 @@ - A receptor-type tyrosine-protein phosphatase C that is a translation product of a mature transcript of the PTPRC gene, that minimally includes the region encoded by the variable exon 4(A). + A receptor-type tyrosine-protein phosphatase C that is a translation product of a transcript that minimally includes the region encoded by the variable exon 4(A). GOC:add PRO:ADD PRO:DAN @@ -20258,6 +21512,82 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A homeobox protein Meis2 that is encoded in the genome of human. + UniProtKB:O14770 + Meis1-related protein 1 (human) + hMEIS2 + protein + MEIS2 + MRG1 + PR:O14770 + Category=organism-gene. + homeobox protein Meis2 (human) + + + + + A homeobox protein Meis2 that is encoded in the genome of human. + PRO:DNx + UniProtKB:O14770 + + + + + Meis1-related protein 1 (human) + UniProtKB:O14770 + + + + + hMEIS2 + PRO:DNx + + + + + + MEIS2 + UniProtKB:O14770 + + + + + + MRG1 + UniProtKB:O14770 + + + + + @@ -21074,7 +22404,7 @@ A natural cytotoxicity triggering receptor 1 that is encoded in the genome of human. NK cell-activating receptor (human) - UniProtKB:O76036 + UniProtKB:O76036 CD335 (human) NK-p46 (human) NKp46 (human) @@ -21094,31 +22424,31 @@ A natural cytotoxicity triggering receptor 1 that is encoded in the genome of human. PRO:WCB - UniProtKB:O76036 + UniProtKB:O76036 NK cell-activating receptor (human) - UniProtKB:O76036 + UniProtKB:O76036 CD335 (human) - UniProtKB:O76036 + UniProtKB:O76036 NK-p46 (human) - UniProtKB:O76036 + UniProtKB:O76036 NKp46 (human) - UniProtKB:O76036 + UniProtKB:O76036 @@ -21131,32 +22461,138 @@ hNKp46 - UniProtKB:O76036 + UniProtKB:O76036 lymphocyte antigen 94 homolog (human) - UniProtKB:O76036 + UniProtKB:O76036 natural killer cell p46-related protein (human) - UniProtKB:O76036 + UniProtKB:O76036 LY94 - UniProtKB:O76036 + UniProtKB:O76036 NCR1 - UniProtKB:O76036 + UniProtKB:O76036 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A gamma-synuclein that is encoded in the genome of human. + UniProtKB:O76070 + SR (human) + breast cancer-specific gene 1 protein (human) + hSNCG + synoretin (human) + protein + BCSG1 + PERSYN + PRSN + SNCG + PR:O76070 + Category=organism-gene. + gamma-synuclein (human) + + + + + A gamma-synuclein that is encoded in the genome of human. + PRO:DNx + UniProtKB:O76070 + + + + + SR (human) + UniProtKB:O76070 + + + + + breast cancer-specific gene 1 protein (human) + UniProtKB:O76070 + + + + + hSNCG + PRO:DNx + + + + + + synoretin (human) + UniProtKB:O76070 + + + + + BCSG1 + UniProtKB:O76070 + + + + + + PERSYN + UniProtKB:O76070 + + + + + + PRSN + UniProtKB:O76070 + + + + + + SNCG + UniProtKB:O76070 @@ -21221,12 +22657,6 @@ PRO:DNx - - - - mCD83 - UniProtKB:O88324 - @@ -21925,6 +23355,81 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A VIP peptides that is encoded in the genome of human. + UniProtKB:P01282 + hVIP + vasoactive intestinal peptides (human) + vasoactive intestinal polypeptides (human) + protein + VIP + PR:P01282 + Category=organism-gene. + VIP peptides (human) + + + + + A VIP peptides that is encoded in the genome of human. + PRO:DNx + UniProtKB:P01282 + + + + + hVIP + PRO:DNx + + + + + + vasoactive intestinal peptides (human) + PRO:DAN + + + + + vasoactive intestinal polypeptides (human) + PRO:DAN + + + + + VIP + UniProtKB:P01282 + + + + + @@ -22787,6 +24292,74 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A collagen alpha-1(I) chain that is encoded in the genome of human. + UniProtKB:P02452 + alpha-1 type I collagen (human) + hCOL1A1 + protein + COL1A1 + PR:P02452 + Category=organism-gene. + collagen alpha-1(I) chain (human) + + + + + A collagen alpha-1(I) chain that is encoded in the genome of human. + PRO:CNA + UniProtKB:P02452 + + + + + alpha-1 type I collagen (human) + UniProtKB:P02452 + + + + + hCOL1A1 + PRO:DNx + + + + + + COL1A1 + UniProtKB:P02452 + + + + + @@ -23994,6 +25567,67 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A cholecystokinin that is encoded in the genome of human. + UniProtKB:P06307 + hCCK + protein + CCK + PR:P06307 + Category=organism-gene. + cholecystokinin (human) + + + + + A cholecystokinin that is encoded in the genome of human. + PRO:DNx + UniProtKB:P06307 + + + + + hCCK + PRO:DNx + + + + + + CCK + UniProtKB:P06307 + + + + + @@ -25929,6 +27563,74 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A cholecystokinin that is encoded in the genome of mouse. + UniProtKB:P09240 + CCK (mouse) + mCCK + protein + Cck + PR:P09240 + Category=organism-gene. + cholecystokinin (mouse) + + + + + A cholecystokinin that is encoded in the genome of mouse. + OMA:P09240 + PRO:DNx + + + + + CCK (mouse) + UniProtKB:P09240 + + + + + mCCK + PRO:DNx + + + + + + Cck + UniProtKB:P09240 + + + + + @@ -27740,6 +29442,82 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A collagen alpha-1(I) chain that is encoded in the genome of mouse. + UniProtKB:P11087 + alpha-1 type I collagen (mouse) + mCOL1A1 + protein + Col1a1 + Cola1 + PR:P11087 + Category=organism-gene. + collagen alpha-1(I) chain (mouse) + + + + + A collagen alpha-1(I) chain that is encoded in the genome of mouse. + OMA:P11087 + PRO:DNx + + + + + alpha-1 type I collagen (mouse) + UniProtKB:P11087 + + + + + mCOL1A1 + PRO:DNx + + + + + + Col1a1 + UniProtKB:P11087 + + + + + + Cola1 + UniProtKB:P11087 + + + + + @@ -31467,6 +33245,154 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An alpha-type platelet-derived growth factor receptor that is encoded in the genome of human. + DTO:03100403 + UniProtKB:P16234 + CD140 antigen-like family member A (human) + CD140a (human) + CD140a antigen (human) + PDGF-R-alpha (human) + PDGFR-2 (human) + PDGFR-alpha (human) + alpha platelet-derived growth factor receptor (human) + alpha-type platelet-derived growth factor receptor (human) + hPDGFRA + platelet-derived growth factor alpha receptor (human) + platelet-derived growth factor receptor 2 (human) + protein + PDGFR2 + PDGFRA + RHEPDGFRA + PR:P16234 + Category=organism-gene. + platelet-derived growth factor receptor alpha (human) + + + + + An alpha-type platelet-derived growth factor receptor that is encoded in the genome of human. + PRO:WCB + UniProtKB:P16234 + + + + + CD140 antigen-like family member A (human) + UniProtKB:P16234 + + + + + CD140a (human) + UniProtKB:P16234 + + + + + CD140a antigen (human) + UniProtKB:P16234 + + + + + PDGF-R-alpha (human) + UniProtKB:P16234 + + + + + PDGFR-2 (human) + UniProtKB:P16234 + + + + + PDGFR-alpha (human) + UniProtKB:P16234 + + + + + alpha platelet-derived growth factor receptor (human) + UniProtKB:P16234 + + + + + alpha-type platelet-derived growth factor receptor (human) + UniProtKB:P16234 + + + + + hPDGFRA + PRO:DNx + + + + + + platelet-derived growth factor alpha receptor (human) + UniProtKB:P16234 + + + + + platelet-derived growth factor receptor 2 (human) + UniProtKB:P16234 + + + + + PDGFR2 + UniProtKB:P16234 + + + + + + PDGFRA + UniProtKB:P16234 + + + + + + RHEPDGFRA + UniProtKB:P16234 + + + + + @@ -33694,6 +35620,67 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A parvalbumin alpha that is encoded in the genome of human. + UniProtKB:P20472 + hPVALB + protein + PVALB + PR:P20472 + Category=organism-gene. + parvalbumin alpha (human) + + + + + A parvalbumin alpha that is encoded in the genome of human. + PRO:DNx + UniProtKB:P20472 + + + + + hPVALB + PRO:DNx + + + + + + PVALB + UniProtKB:P20472 + + + + + @@ -36050,6 +38037,116 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An alpha-type platelet-derived growth factor receptor that is encoded in the genome of mouse. + UniProtKB:P26618 + CD140 antigen-like family member A (mouse) + CD140a (mouse) + PDGF-R-alpha (mouse) + PDGFR-alpha (mouse) + alpha platelet-derived growth factor receptor (mouse) + alpha-type platelet-derived growth factor receptor (mouse) + mPDGFRA + platelet-derived growth factor alpha receptor (mouse) + protein + Pdgfra + PR:P26618 + Category=organism-gene. + platelet-derived growth factor receptor alpha (mouse) + + + + + An alpha-type platelet-derived growth factor receptor that is encoded in the genome of mouse. + OMA:P26618 + PRO:DNx + + + + + CD140 antigen-like family member A (mouse) + UniProtKB:P26618 + + + + + CD140a (mouse) + UniProtKB:P26618 + + + + + PDGF-R-alpha (mouse) + UniProtKB:P26618 + + + + + PDGFR-alpha (mouse) + UniProtKB:P26618 + + + + + alpha platelet-derived growth factor receptor (mouse) + UniProtKB:P26618 + + + + + alpha-type platelet-derived growth factor receptor (mouse) + UniProtKB:P26618 + + + + + mPDGFRA + PRO:DNx + + + + + + platelet-derived growth factor alpha receptor (mouse) + UniProtKB:P26618 + + + + + Pdgfra + UniProtKB:P26618 + + + + + @@ -36183,7 +38280,7 @@ A CD27 molecule that is encoded in the genome of human. - UniProtKB:P26842 + UniProtKB:P26842 CD27L receptor (human) T-cell activation antigen CD27 (human) T14 (human) @@ -36201,25 +38298,25 @@ A CD27 molecule that is encoded in the genome of human. PRO:WCB - UniProtKB:P26842 + UniProtKB:P26842 CD27L receptor (human) - UniProtKB:P26842 + UniProtKB:P26842 T-cell activation antigen CD27 (human) - UniProtKB:P26842 + UniProtKB:P26842 T14 (human) - UniProtKB:P26842 + UniProtKB:P26842 @@ -36232,20 +38329,20 @@ tumor necrosis factor receptor superfamily member 7 (human) - UniProtKB:P26842 + UniProtKB:P26842 CD27 - UniProtKB:P26842 + UniProtKB:P26842 TNFRSF7 - UniProtKB:P26842 + UniProtKB:P26842 @@ -37989,6 +40086,136 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A VIP peptides that is encoded in the genome of mouse. + UniProtKB:P32648 + mVIP + protein + Vip + PR:P32648 + Category=organism-gene. + VIP peptides (mouse) + + + + + A VIP peptides that is encoded in the genome of mouse. + OMA:P32648 + PRO:DNx + + + + + mVIP + PRO:DNx + + + + + + Vip + UniProtKB:P32648 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A parvalbumin alpha that is encoded in the genome of mouse. + UniProtKB:P32848 + mPVALB + protein + Pva + Pvalb + PR:P32848 + Category=organism-gene. + parvalbumin alpha (mouse) + + + + + A parvalbumin alpha that is encoded in the genome of mouse. + OMA:P32848 + PRO:DNx + + + + + mPVALB + PRO:DNx + + + + + + Pva + UniProtKB:P32848 + + + + + + Pvalb + UniProtKB:P32848 + + + + + @@ -38988,6 +41215,76 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A neuronal acetylcholine receptor subunit alpha-7 that is encoded in the genome of human. + DTO:01100012 + UniProtKB:P36544 + hCHRNA7 + protein + CHRNA7 + NACHRA7 + PR:P36544 + Category=organism-gene. + neuronal acetylcholine receptor subunit alpha-7 (human) + + + + + A neuronal acetylcholine receptor subunit alpha-7 that is encoded in the genome of human. + PRO:DNx + UniProtKB:P36544 + + + + + hCHRNA7 + PRO:DNx + + + + + + CHRNA7 + UniProtKB:P36544 + + + + + + NACHRA7 + UniProtKB:P36544 + + + + + @@ -40417,6 +42714,74 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A neuronal acetylcholine receptor subunit alpha-7 that is encoded in the genome of mouse. + UniProtKB:P49582 + mChrna7 + protein + Acra7 + Chrna7 + PR:P49582 + Category=organism-gene. + neuronal acetylcholine receptor subunit alpha-7 (mouse) + + + + + A neuronal acetylcholine receptor subunit alpha-7 that is encoded in the genome of mouse. + PRO:DAN + + + + + mChrna7 + PRO:DNx + + + + + + Acra7 + UniProtKB:P49582 + + + + + + Chrna7 + UniProtKB:P49582 + + + + + @@ -42227,6 +44592,188 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A lumican that is encoded in the genome of human. + UniProtKB:P51884 + KSPG lumican (human) + hLUM + keratan sulfate proteoglycan lumican (human) + protein + LDC + LUM + SLRR2D + PR:P51884 + Category=organism-gene. + lumican (human) + + + + + A lumican that is encoded in the genome of human. + PRO:DNx + UniProtKB:P51884 + + + + + KSPG lumican (human) + UniProtKB:P51884 + + + + + hLUM + PRO:DNx + + + + + + keratan sulfate proteoglycan lumican (human) + UniProtKB:P51884 + + + + + LDC + UniProtKB:P51884 + + + + + + LUM + UniProtKB:P51884 + + + + + + SLRR2D + UniProtKB:P51884 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A lumican that is encoded in the genome of mouse. + UniProtKB:P51885 + KSPG lumican (mouse) + keratan sulfate proteoglycan lumican (mouse) + mLUM + protein + Lcn + Ldc + Lum + PR:P51885 + Category=organism-gene. + lumican (mouse) + + + + + A lumican that is encoded in the genome of mouse. + OMA:P51885 + PRO:DNx + + + + + KSPG lumican (mouse) + UniProtKB:P51885 + + + + + keratan sulfate proteoglycan lumican (mouse) + UniProtKB:P51885 + + + + + mLUM + PRO:DNx + + + + + + Lcn + UniProtKB:P51885 + + + + + + Ldc + UniProtKB:P51885 + + + + + + Lum + UniProtKB:P51885 + + + + + @@ -42749,6 +45296,75 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A somatostatin that is encoded in the genome of mouse. + UniProtKB:P60041 + mSST + protein + Smst + Sst + PR:P60041 + Category=organism-gene. + somatostatin (mouse) + + + + + A somatostatin that is encoded in the genome of mouse. + OMA:P60041 + PRO:DNx + + + + + mSST + PRO:DNx + + + + + + Smst + UniProtKB:P60041 + + + + + + Sst + UniProtKB:P60041 + + + + + @@ -42923,6 +45539,74 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A somatostatin that is encoded in the genome of human. + UniProtKB:P61278 + growth hormone release-inhibiting factor (human) + hSST + protein + SST + PR:P61278 + Category=organism-gene. + somatostatin (human) + + + + + A somatostatin that is encoded in the genome of human. + PRO:DNx + UniProtKB:P61278 + + + + + growth hormone release-inhibiting factor (human) + UniProtKB:P61278 + + + + + hSST + PRO:DNx + + + + + + SST + UniProtKB:P61278 + + + + + @@ -43495,6 +46179,90 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A homeobox protein Meis2 that is encoded in the genome of mouse. + UniProtKB:P97367 + Meis1-related protein 1 (mouse) + mMEIS2 + protein + Meis2 + Mrg1 + Stra10 + PR:P97367 + Category=organism-gene. + homeobox protein Meis2 (mouse) + + + + + A homeobox protein Meis2 that is encoded in the genome of mouse. + OMA:P97367 + PRO:DNx + + + + + Meis1-related protein 1 (mouse) + UniProtKB:P97367 + + + + + mMEIS2 + PRO:DNx + + + + + + Meis2 + UniProtKB:P97367 + + + + + + Mrg1 + UniProtKB:P97367 + + + + + + Stra10 + UniProtKB:P97367 + + + + + @@ -50956,6 +53724,102 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A lysosome-associated membrane glycoprotein 5 that is encoded in the genome of mouse. + UniProtKB:Q9D387 + BAD-LAMP (mouse) + LAMP-5 (mouse) + brain and dendritic cell-associated LAMP (mouse) + brain-associated LAMP-like protein (mouse) + lysosome-associated membrane protein 5 (mouse) + mLAMP5 + protein + Lamp5 + PR:Q9D387 + Category=organism-gene. + lysosome-associated membrane glycoprotein 5 (mouse) + + + + + A lysosome-associated membrane glycoprotein 5 that is encoded in the genome of mouse. + OMA:Q9D387 + PRO:DNx + + + + + BAD-LAMP (mouse) + UniProtKB:Q9D387 + + + + + LAMP-5 (mouse) + UniProtKB:Q9D387 + + + + + brain and dendritic cell-associated LAMP (mouse) + UniProtKB:Q9D387 + + + + + brain-associated LAMP-like protein (mouse) + UniProtKB:Q9D387 + + + + + lysosome-associated membrane protein 5 (mouse) + UniProtKB:Q9D387 + + + + + mLAMP5 + PRO:DNx + + + + + + Lamp5 + UniProtKB:Q9D387 + + + + + @@ -51413,7 +54277,7 @@ A CD209 molecule that is encoded in the genome of human. Reactome:R-HSA-2079928 - UniProtKB:Q9NNX6 + UniProtKB:Q9NNX6 C-type lectin domain family 4 member L (human) DC-SIGN (human) DC-SIGN1 (human) @@ -51431,7 +54295,7 @@ A CD209 molecule that is encoded in the genome of human. PRO:WCB - UniProtKB:Q9NNX6 + UniProtKB:Q9NNX6 @@ -51443,25 +54307,25 @@ C-type lectin domain family 4 member L (human) - UniProtKB:Q9NNX6 + UniProtKB:Q9NNX6 DC-SIGN (human) - UniProtKB:Q9NNX6 + UniProtKB:Q9NNX6 DC-SIGN1 (human) - UniProtKB:Q9NNX6 + UniProtKB:Q9NNX6 dendritic cell-specific ICAM-3-grabbing non-integrin 1 (human) - UniProtKB:Q9NNX6 + UniProtKB:Q9NNX6 @@ -51474,14 +54338,14 @@ CD209 - UniProtKB:Q9NNX6 + UniProtKB:Q9NNX6 CLEC4L - UniProtKB:Q9NNX6 + UniProtKB:Q9NNX6 @@ -51516,7 +54380,7 @@ A lactosylceramide 4-alpha-galactosyltransferase that is encoded in the genome of human. - UniProtKB:Q9NPC4 + UniProtKB:Q9NPC4 CD77 synthase (human) Gb3 synthase (human) P1/Pk synthase (human) @@ -51539,49 +54403,49 @@ A lactosylceramide 4-alpha-galactosyltransferase that is encoded in the genome of human. PRO:DNx - UniProtKB:Q9NPC4 + UniProtKB:Q9NPC4 CD77 synthase (human) - UniProtKB:Q9NPC4 + UniProtKB:Q9NPC4 Gb3 synthase (human) - UniProtKB:Q9NPC4 + UniProtKB:Q9NPC4 P1/Pk synthase (human) - UniProtKB:Q9NPC4 + UniProtKB:Q9NPC4 UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase (human) - UniProtKB:Q9NPC4 + UniProtKB:Q9NPC4 alpha-1,4-galactosyltransferase (human) - UniProtKB:Q9NPC4 + UniProtKB:Q9NPC4 alpha4Gal-T1 (human) - UniProtKB:Q9NPC4 + UniProtKB:Q9NPC4 globotriaosylceramide synthase (human) - UniProtKB:Q9NPC4 + UniProtKB:Q9NPC4 @@ -51594,28 +54458,28 @@ A14GALT - UniProtKB:Q9NPC4 + UniProtKB:Q9NPC4 A4GALT - UniProtKB:Q9NPC4 + UniProtKB:Q9NPC4 A4GALT1 - UniProtKB:Q9NPC4 + UniProtKB:Q9NPC4 alpha-1,4-N-acetylglucosaminyltransferase (human) - UniProtKB:Q9NPC4 + UniProtKB:Q9NPC4 @@ -51775,7 +54639,7 @@ An interleukin-17 receptor B that is encoded in the genome of human. - UniProtKB:Q9NRM6 + UniProtKB:Q9NRM6 IL-17 receptor B (human) IL-17 receptor homolog 1 (human) IL-17B receptor (human) @@ -51800,49 +54664,49 @@ An interleukin-17 receptor B that is encoded in the genome of human. PRO:DNx - UniProtKB:Q9NRM6 + UniProtKB:Q9NRM6 IL-17 receptor B (human) - UniProtKB:Q9NRM6 + UniProtKB:Q9NRM6 IL-17 receptor homolog 1 (human) - UniProtKB:Q9NRM6 + UniProtKB:Q9NRM6 IL-17B receptor (human) - UniProtKB:Q9NRM6 + UniProtKB:Q9NRM6 IL-17RB (human) - UniProtKB:Q9NRM6 + UniProtKB:Q9NRM6 IL-17Rh1 (human) - UniProtKB:Q9NRM6 + UniProtKB:Q9NRM6 IL17Rh1 (human) - UniProtKB:Q9NRM6 + UniProtKB:Q9NRM6 cytokine receptor-like 4 (human) - UniProtKB:Q9NRM6 + UniProtKB:Q9NRM6 @@ -51855,41 +54719,41 @@ interleukin-17B receptor (human) - UniProtKB:Q9NRM6 + UniProtKB:Q9NRM6 CRL4 - UniProtKB:Q9NRM6 + UniProtKB:Q9NRM6 EVI27 - UniProtKB:Q9NRM6 + UniProtKB:Q9NRM6 IL17BR - UniProtKB:Q9NRM6 + UniProtKB:Q9NRM6 IL17RB - UniProtKB:Q9NRM6 + UniProtKB:Q9NRM6 UNQ2501/PRO19612 - UniProtKB:Q9NRM6 + UniProtKB:Q9NRM6 @@ -52627,6 +55491,110 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A lysosome-associated membrane glycoprotein 5 that is encoded in the genome of human. + UniProtKB:Q9UJQ1 + BAD-LAMP (human) + LAMP-5 (human) + brain and dendritic cell-associated LAMP (human) + brain-associated LAMP-like protein (human) + hLAMP5 + lysosome-associated membrane protein 5 (human) + protein + C20orf103 + LAMP5 + PR:Q9UJQ1 + Category=organism-gene. + lysosome-associated membrane glycoprotein 5 (human) + + + + + A lysosome-associated membrane glycoprotein 5 that is encoded in the genome of human. + PRO:DNx + UniProtKB:Q9UJQ1 + + + + + BAD-LAMP (human) + UniProtKB:Q9UJQ1 + + + + + LAMP-5 (human) + UniProtKB:Q9UJQ1 + + + + + brain and dendritic cell-associated LAMP (human) + UniProtKB:Q9UJQ1 + + + + + brain-associated LAMP-like protein (human) + UniProtKB:Q9UJQ1 + + + + + hLAMP5 + PRO:DNx + + + + + + lysosome-associated membrane protein 5 (human) + UniProtKB:Q9UJQ1 + + + + + C20orf103 + UniProtKB:Q9UJQ1 + + + + + + LAMP5 + UniProtKB:Q9UJQ1 + + + + + @@ -52940,7 +55908,7 @@ A netrin-G1 that is encoded in the genome of human. - UniProtKB:Q9Y2I2 + UniProtKB:Q9Y2I2 hNTNG1 laminet-1 (human) protein @@ -52957,7 +55925,7 @@ A netrin-G1 that is encoded in the genome of human. PRO:DNx - UniProtKB:Q9Y2I2 + UniProtKB:Q9Y2I2 @@ -52970,34 +55938,34 @@ laminet-1 (human) - UniProtKB:Q9Y2I2 + UniProtKB:Q9Y2I2 KIAA0976 - UniProtKB:Q9Y2I2 + UniProtKB:Q9Y2I2 LMNT1 - UniProtKB:Q9Y2I2 + UniProtKB:Q9Y2I2 NTNG1 - UniProtKB:Q9Y2I2 + UniProtKB:Q9Y2I2 UNQ571/PRO1133 - UniProtKB:Q9Y2I2 + UniProtKB:Q9Y2I2 @@ -53379,6 +56347,82 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A gamma-synuclein that is encoded in the genome of mouse. + UniProtKB:Q9Z0F7 + mSNCG + persyn (mouse) + protein + Persyn + Sncg + PR:Q9Z0F7 + Category=organism-gene. + gamma-synuclein (mouse) + + + + + A gamma-synuclein that is encoded in the genome of mouse. + OMA:Q9Z0F7 + PRO:DNx + + + + + mSNCG + PRO:DNx + + + + + + persyn (mouse) + UniProtKB:Q9Z0F7 + + + + + Persyn + UniProtKB:Q9Z0F7 + + + + + + Sncg + UniProtKB:Q9Z0F7 + + + + + @@ -53484,6 +56528,7 @@ protein-coding sequence SO:0000010 + Category=external. protein_coding @@ -53851,6 +56896,31 @@ + + + + + + + + + + + A protein coding gene SNCG in human. + gene + HGNC:11141 + Category=external. + SNCG (human) + + + + + A protein coding gene SNCG in human. + PRO:DNx + + + + @@ -53926,6 +56996,31 @@ + + + + + + + + + + + A protein coding gene SST in human. + gene + HGNC:11329 + Category=external. + SST (human) + + + + + A protein coding gene SST in human. + PRO:DNx + + + + @@ -54176,6 +57271,31 @@ + + + + + + + + + + + A protein coding gene VIP in human. + gene + HGNC:12693 + Category=external. + VIP (human) + + + + + A protein coding gene VIP in human. + PRO:DNx + + + + @@ -54351,6 +57471,31 @@ + + + + + + + + + + + A protein coding gene CCK in human. + gene + HGNC:1569 + Category=external. + CCK (human) + + + + + A protein coding gene CCK in human. + PRO:DNx + + + + @@ -54551,6 +57696,31 @@ + + + + + + + + + + + A protein coding gene LAMP5 in human. + gene + HGNC:16097 + Category=external. + LAMP5 (human) + + + + + A protein coding gene LAMP5 in human. + PRO:DNx + + + + @@ -55551,6 +58721,56 @@ + + + + + + + + + + + A protein coding gene CHRNA7 in human. + gene + HGNC:1960 + Category=external. + CHRNA7 (human) + + + + + A protein coding gene CHRNA7 in human. + PRO:DNx + + + + + + + + + + + + + + + A protein coding gene COL1A1 in human. + gene + HGNC:2197 + Category=external. + COL1A1 (human) + + + + + A protein coding gene COL1A1 in human. + PRO:DNx + + + + @@ -57176,6 +60396,31 @@ + + + + + + + + + + + A protein coding gene LUM in human. + gene + HGNC:6724 + Category=external. + LUM (human) + + + + + A protein coding gene LUM in human. + PRO:DNx + + + + @@ -57276,6 +60521,31 @@ + + + + + + + + + + + A protein coding gene MEIS2 in human. + gene + HGNC:7001 + Category=external. + MEIS2 (human) + + + + + A protein coding gene MEIS2 in human. + PRO:DNx + + + + @@ -57551,6 +60821,31 @@ + + + + + + + + + + + A protein coding gene PDGFRA in human. + gene + HGNC:8803 + Category=external. + PDGFRA (human) + + + + + A protein coding gene PDGFRA in human. + PRO:DNx + + + + @@ -57701,6 +60996,31 @@ + + + + + + + + + + + A protein coding gene PVALB in human. + gene + HGNC:9704 + Category=external. + PVALB (human) + + + + + A protein coding gene PVALB in human. + PRO:DNx + + + + @@ -58651,6 +61971,31 @@ + + + + + + + + + + + A protein coding gene Meis2 in mouse. + gene + MGI:108564 + Category=external. + Meis2 (mouse) + + + + + A protein coding gene Meis2 in mouse. + PRO:DNx + + + + @@ -58676,6 +62021,31 @@ + + + + + + + + + + + A protein coding gene Lum in mouse. + gene + MGI:109347 + Category=external. + Lum (mouse) + + + + + A protein coding gene Lum in mouse. + PRO:DNx + + + + @@ -58901,6 +62271,31 @@ + + + + + + + + + + + A protein coding gene Sncg in mouse. + gene + MGI:1298397 + Category=external. + Sncg (mouse) + + + + + A protein coding gene Sncg in mouse. + PRO:DNx + + + + @@ -59451,6 +62846,31 @@ + + + + + + + + + + + A protein coding gene Lamp5 in mouse. + gene + MGI:1923411 + Category=external. + Lamp5 (mouse) + + + + + A protein coding gene Lamp5 in mouse. + PRO:DNx + + + + @@ -59726,6 +63146,31 @@ + + + + + + + + + + + A protein coding gene Cck in mouse. + gene + MGI:88297 + Category=external. + Cck (mouse) + + + + + A protein coding gene Cck in mouse. + PRO:DNx + + + + @@ -60276,6 +63721,31 @@ + + + + + + + + + + + A protein coding gene Col1a1 in mouse. + gene + MGI:88467 + Category=external. + Col1a1 (mouse) + + + + + A protein coding gene Col1a1 in mouse. + PRO:DNx + + + + @@ -61326,6 +64796,31 @@ + + + + + + + + + + + A protein coding gene Pdgfra in mouse. + gene + MGI:97530 + Category=external. + Pdgfra (mouse) + + + + + A protein coding gene Pdgfra in mouse. + PRO:DNx + + + + @@ -61376,6 +64871,31 @@ + + + + + + + + + + + A protein coding gene Pvalb in mouse. + gene + MGI:97821 + Category=external. + Pvalb (mouse) + + + + + A protein coding gene Pvalb in mouse. + PRO:DNx + + + + @@ -61501,6 +65021,31 @@ + + + + + + + + + + + A protein coding gene Sst in mouse. + gene + MGI:98326 + Category=external. + Sst (mouse) + + + + + A protein coding gene Sst in mouse. + PRO:DNx + + + + @@ -61676,6 +65221,31 @@ + + + + + + + + + + + A protein coding gene Vip in mouse. + gene + MGI:98933 + Category=external. + Vip (mouse) + + + + + A protein coding gene Vip in mouse. + PRO:DNx + + + + @@ -61751,6 +65321,31 @@ + + + + + + + + + + + A protein coding gene Chrna7 in mouse. + gene + MGI:99779 + Category=external. + Chrna7 (mouse) + + + + + A protein coding gene Chrna7 in mouse. + PRO:DNx + + + + diff --git a/imports/ro_import.owl b/imports/ro_import.owl index d527c7da8..45ede8c15 100644 --- a/imports/ro_import.owl +++ b/imports/ro_import.owl @@ -8,8 +8,8 @@ xmlns:xml="http://www.w3.org/XML/1998/namespace" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" xmlns:cito="http://purl.org/spar/cito/" - xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" + xmlns:skos="http://www.w3.org/2004/02/skos/core#" xmlns:swrl="http://www.w3.org/2003/11/swrl#" xmlns:swrla="http://swrl.stanford.edu/ontologies/3.3/swrla.owl#" xmlns:swrlb="http://www.w3.org/2003/11/swrlb#" @@ -17,8 +17,9 @@ xmlns:subsets="http://purl.obolibrary.org/obo/ro/subsets#" xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"> - - 2021-02-01 + + + 2021-06-28 @@ -114,6 +115,12 @@ + + + + + + @@ -147,6 +154,18 @@ + + + + S present_in_taxon T if some instance of T has some S. This does not means that all instances of T have an S - it may only be certain life stages or sexes that have S + https://orcid.org/0000-0002-6601-2165 + + present in taxon + + + + + @@ -255,6 +274,12 @@ + + + + + + @@ -389,9 +414,15 @@ - + + + + + + + - + @@ -418,7 +449,7 @@ this day is part of this year (occurrent parthood) a core relation that holds between a part and its whole Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other. - Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime + Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/ Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.) A continuant cannot be part of an occurrent: use 'participates in'. An occurrent cannot be part of a continuant: use 'has participant'. A material entity cannot be part of an immaterial entity: use 'has location'. A specifically dependent continuant cannot be part of an independent continuant: use 'inheres in'. An independent continuant cannot be part of a specifically dependent continuant: use 'bearer of'. @@ -454,7 +485,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An this year has part this day (occurrent parthood) a core relation that holds between a whole and its part Everything has itself as a part. Any part of any part of a thing is itself part of that thing. Two distinct things cannot have each other as a part. - Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime + Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/ Parthood requires the part and the whole to have compatible classes: only an occurrent have an occurrent as part; only a process can have a process as part; only a continuant can have a continuant as part; only an independent continuant can have an independent continuant as part; only a specifically dependent continuant can have a specifically dependent continuant as part; only a generically dependent continuant can have a generically dependent continuant as part. (This list is not exhaustive.) A continuant cannot have an occurrent as part: use 'participates in'. An occurrent cannot have a continuant as part: use 'has participant'. An immaterial entity cannot have a material entity as part: use 'location of'. An independent continuant cannot have a specifically dependent continuant as part: use 'bearer of'. A specifically dependent continuant cannot have an independent continuant as part: use 'inheres in'. @@ -557,14 +588,15 @@ A continuant cannot have an occurrent as part: use 'participates in'. + inheres in - this fragility inheres in this vase - this red color inheres in this apple - a relation between a specifically dependent continuant (the dependent) and an independent continuant (the bearer), in which the dependent specifically depends on the bearer for its existence - A dependent inheres in its bearer at all times for which the dependent exists. + this fragility is a characteristic of this vase + this red color is a characteristic of this apple + a relation between a specifically dependent continuant (the characteristic) and any other entity (the bearer), in which the characteristic depends on the bearer for its existence. inheres_in - inheres in + Note that this relation was previously called "inheres in", but was changed to be called "characteristic of" because BFO2 uses "inheres in" in a more restricted fashion. This relation differs from BFO2:inheres_in in two respects: (1) it does not impose a range constraint, and thus it allows qualities of processes, as well as of information entities, whereas BFO2 restricts inheres_in to only apply to independent continuants (2) it is declared functional, i.e. something can only be a characteristic of one thing. + characteristic of @@ -572,16 +604,17 @@ A continuant cannot have an occurrent as part: use 'participates in'. + bearer of this apple is bearer of this red color this vase is bearer of this fragility - a relation between an independent continuant (the bearer) and a specifically dependent continuant (the dependent), in which the dependent specifically depends on the bearer for its existence + Inverse of characteristic_of A bearer can have many dependents, and its dependents can exist for different periods of time, but none of its dependents can exist when the bearer does not exist. bearer_of is bearer of - bearer of + has characteristic @@ -625,6 +658,124 @@ A continuant cannot have an occurrent as part: use 'participates in'. + + + + + + + this catalysis function is a function of this enzyme + a relation between a function and an independent continuant (the bearer), in which the function specifically depends on the bearer for its existence + A function inheres in its bearer at all times for which the function exists, however the function need not be realized at all the times that the function exists. + function_of + is function of + This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020. + function of + + + + + + + + + + this red color is a quality of this apple + a relation between a quality and an independent continuant (the bearer), in which the quality specifically depends on the bearer for its existence + A quality inheres in its bearer at all times for which the quality exists. + is quality of + quality_of + This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020. + quality of + + + + + + + + + + this investigator role is a role of this person + a relation between a role and an independent continuant (the bearer), in which the role specifically depends on the bearer for its existence + A role inheres in its bearer at all times for which the role exists, however the role need not be realized at all the times that the role exists. + is role of + role_of + This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020. + role of + + + + + + + + + + + this enzyme has function this catalysis function (more colloquially: this enzyme has this catalysis function) + a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence + A bearer can have many functions, and its functions can exist for different periods of time, but none of its functions can exist when the bearer does not exist. A function need not be realized at all the times that the function exists. + has_function + has function + + + + + + + + + + this apple has quality this red color + a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence + A bearer can have many qualities, and its qualities can exist for different periods of time, but none of its qualities can exist when the bearer does not exist. + has_quality + has quality + + + + + + + + + + + this person has role this investigator role (more colloquially: this person has this role of investigator) + a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence + A bearer can have many roles, and its roles can exist for different periods of time, but none of its roles can exist when the bearer does not exist. A role need not be realized at all the times that the role exists. + has_role + has role + + + + + + + + + + + + a relation between an independent continuant (the bearer) and a disposition, in which the disposition specifically depends on the bearer for its existence + has disposition + + + + + + + + + inverse of has disposition + + This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020. + disposition of + + + + @@ -666,7 +817,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. my head is the location of my brain this cage is the location of this rat a relation between two independent continuants, the location and the target, in which the target is entirely within the location - Most location relations will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime + Most location relations will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/ location_of location of @@ -745,10 +896,11 @@ range: spatial region or site (immaterial continuant) this rat is located in this cage a relation between two independent continuants, the target and the location, in which the target is entirely within the location Location as a relation between instances: The primitive instance-level relation c located_in r at t reflects the fact that each continuant is at any given time associated with exactly one spatial region, namely its exact location. Following we can use this relation to define a further instance-level location relation - not between a continuant and the region which it exactly occupies, but rather between one continuant and another. c is located in c1, in this sense, whenever the spatial region occupied by c is part_of the spatial region occupied by c1. Note that this relation comprehends both the relation of exact location between one continuant and another which obtains when r and r1 are identical (for example, when a portion of fluid exactly fills a cavity), as well as those sorts of inexact location relations which obtain, for example, between brain and head or between ovum and uterus - Most location relations will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime + Most location relations will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/ located_in http://www.obofoundry.org/ro/#OBO_REL:located_in + located in @@ -785,6 +937,7 @@ range: spatial region or site (immaterial continuant) David Osumi-Sutherland + has synaptic terminal of @@ -996,6 +1149,45 @@ range: spatial region or site (immaterial continuant) + + + + + + + + + relationship between a neuron and a neuron projection bundle (e.g.- tract or nerve bundle) that one or more of its projections travels through. + + David Osumi-Sutherland + fasciculates with + (forall (?x ?y) + (iff + (fasciculates_with ?x ?y) + (exists (?nps ?npbs) + (and + ("neuron ; CL_0000540" ?x) + ("neuron projection bundle ; CARO_0001001" ?y) + ("neuron projection segment ; CARO_0001502" ?nps) + ("neuron projection bundle segment ; CARO_0001500' " ?npbs) + (part_of ?npbs ?y) + (part_of ?nps ?x) + (part_of ?nps ?npbs) + (forall (?npbss) + (if + (and + ("neuron projection bundle subsegment ; CARO_0001501" ?npbss) + (part_of ?npbss ?npbs) + ) + (overlaps ?nps ?npbss) + )))))) + + + fasciculates with + + + + @@ -1211,6 +1403,56 @@ N1 SubclassOf ( + + + + + + + + + + + + + + + + + + The relation between a neuron projection bundle and a neuron projection that is fasciculated with it. + David Osumi-Sutherland + has fasciculating component + (forall (?x ?y) + (iff + (has_fasciculating_neuron_projection ?x ?y) + (exists (?nps ?npbs) + (and + ("neuron projection bundle ; CARO_0001001" ?x) + ("neuron projection ; GO0043005" ?y) + ("neuron projection segment ; CARO_0001502" ?nps) + ("neuron projection bundle segment ; CARO_0001500" ?npbs) + (part_of ?nps ?y) + (part_of ?npbs ?x) + (part_of ?nps ?npbs) + (forall (?npbss) + (if + (and + ("neuron projection bundle subsegment ; CARO_0001501" ?npbss) + (part_of ?npbss ?npbs) + ) + (overlaps ?nps ?npbss) + )))))) + + + + + + has fasciculating neuron projection + + + + @@ -1309,7 +1551,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. spatially disjoint from - https://github.com/obophenotype/uberon/wiki/Part-disjointness-Design-Pattern + https://github.com/obophenotype/uberon/wiki/Part-disjointness-Design-Pattern @@ -1334,8 +1576,8 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.a is connected to b if and only if a and b are discrete structure, and there exists some connecting structure c, such that c connects a and b connected to - https://github.com/obophenotype/uberon/wiki/Connectivity-Design-Pattern - https://github.com/obophenotype/uberon/wiki/Modeling-articulations-Design-Pattern + https://github.com/obophenotype/uberon/wiki/Connectivity-Design-Pattern + https://github.com/obophenotype/uberon/wiki/Modeling-articulations-Design-Pattern @@ -1450,7 +1692,6 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.regulates (processual) false - regulates @@ -1470,7 +1711,6 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.negatively regulates (process to process) - negatively regulates @@ -1495,7 +1735,6 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.positively regulates (process to process) - positively regulates @@ -1536,7 +1775,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.Chris Mungall has function in capable of part of - + @@ -1770,13 +2009,14 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. - q inheres in part of w if and only if there exists some p such that q inheres in p and p part of w. - Because part_of is transitive, inheres in is a sub-relation of inheres in part of + q characteristic of part of w if and only if there exists some p such that q inheres in p and p part of w. + Because part_of is transitive, inheres in is a sub-relation of characteristic of part of Chris Mungall + inheres in part of - inheres in part of - + characteristic of part of + @@ -2299,8 +2539,8 @@ Each of these 3 primitives can be composed to yield a cross-product of different in pairwise interaction with interacts with - http://purl.obolibrary.org/obo/MI_0914 - https://github.com/oborel/obo-relations/wiki/InteractionRelations + http://purl.obolibrary.org/obo/ro/docs/interaction-relations/ + http://purl.obolibrary.org/obo/MI_0914 @@ -2316,7 +2556,7 @@ Each of these 3 primitives can be composed to yield a cross-product of different molecularly binds with molecularly interacts with - http://purl.obolibrary.org/obo/MI_0915 + http://purl.obolibrary.org/obo/MI_0915 @@ -2541,7 +2781,7 @@ For example, A and B may be gene products and binding of B by A positively regul Chris Mungall interaction relation helper property - https://github.com/oborel/obo-relations/wiki/InteractionRelations + http://purl.obolibrary.org/obo/ro/docs/interaction-relations/ @@ -2897,6 +3137,23 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + + + + + A relationship between a neuron and a region, where the neuron has a functionally relevant number of input and/or output synapses in that region. + + 2020-07-17T09:26:52Z + has synaptic input or output in + has synaptic IO in + + + + @@ -2994,6 +3251,48 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + + disposition + + + + + + + + + + + + + + + + A specifically dependent continuant that inheres in continuant entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances. + realizable entity + + + + + + + + + + + + + + + quality + + + + @@ -3011,6 +3310,16 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + A realizable entity the manifestation of which brings about some result or end that is not essential to a continuant in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant in some kinds of natural, social or institutional contexts. + role + + + + @@ -3027,6 +3336,15 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + function + + + + @@ -3316,6 +3634,12 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + + @@ -3425,6 +3749,178 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + true MF(X)-directly_regulates->MF(Y)-enabled_by->GP(Z) => MF(Y)-has_input->GP(Y) e.g. if 'protein kinase activity'(X) directly_regulates 'protein binding activity (Y)and this is enabled by GP(Z) then X has_input Z diff --git a/imports/uberon_import.owl b/imports/uberon_import.owl index 7bb01d333..31dfdaaf0 100644 --- a/imports/uberon_import.owl +++ b/imports/uberon_import.owl @@ -14,8 +14,65 @@ xmlns:terms="http://purl.org/dc/terms/" xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"> - - 2021-02-01 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + ISBN:0030229073 Invertebrate Zoology, Barnes + ISBN:0073040584 Vertebrates, Kardong + ISBN:0123813611 Comparative Anatomy and Histology: A Mouse and Human Atlas, Treuting and Dintzis + ISBN:0226313379 Fins into Limbs: Evolution, Development, and Transformation, Hall + ISBN:0443065837 Human embryology, Larsen + ISBN:0471888893 Comparative Vertebrate Neuroanatomy: Evolution and Adaptation by Butler and Hodos + ISBN:0683400088 Stedman's Medical Dictionary + ISBN:1588900649 Color Atlas and Textbook of Human Anatomy: Nervous system and sensory organs By Werner Kahle, Michael Frotscher + ISBN:1588903958 Principles and practice of pediatric neurosurgery By A. Leland Albright, P. David Adelson, Ian F. Pollack + ISBN:1607950324 Craniofacial Embryogenetics & Development, 2nd edition, Sperber + ISBN:978-0-12-369548-2 Principles of Developmental Genetics, Sally A Moody + ISBN:9780120749034 The laboratory rat + ISBN:9780397517251 Surgical anatomy of the hand and upper extremity. By James R. Doyle and Michael J. Botte + ISBN:9780674021839 The Tree of Life - Guillaume Lecointre, Herve Le Guyader + ISBN:9780878932504 Developmental Biology + MESH + PMID:11433360 Placental development: lessons from mouse mutants + PMID:16417468 Forgotten and novel aspects in pancreas development, Pieler and Chen + http://wiki.phenotypercn.org/wg/phenotypercn/index.php?title=Neural_Crest_Workshop + http://wiki.phenotypercn.org/wiki/August_2012_Notes + https://docs.google.com/document/d/16JZOuH9sh_a8uIXA4cqg0Q1H6MV5yCj3-rhuKsZoV_U/edit + https://docs.google.com/document/d/1MnUgispgGfNQoezYzWzzGTnkAnI0gzRnJIwdip6MMtw/edit + https://docs.google.com/document/d/1cPWBqrl_Qy7XHEWFqtR_PgQX61yRkgGuLaiDpnEXxkE/edit + https://docs.google.com/document/d/1r9kNPpFYGdu0SpJDLyFAVQczBlG0wAZCBMd18gG3Ot8/edit# + https://docs.google.com/spreadsheet/ccc?key=0Aj8NJdyb-leqdDM0R3hTVTRHRExDVjRCSkZEbDc5N1E#gid=0 + 2021-06-28 @@ -116,7 +173,23 @@ - + + S present_in_taxon T if some instance of T has some S. This does not means that all instances of T have an S - it may only be certain life stages or sexes that have S + RO:0002175 + applicable for taxon + uberon + present_in_taxon + true + true + present_in_taxon + present_in_taxon + + + + + S present_in_taxon T if some instance of T has some S. This does not means that all instances of T have an S - it may only be certain life stages or sexes that have S + + @@ -800,7 +873,14 @@ - + + + uberon + depicted_by + true + depicted_by + depicted by + @@ -2370,14 +2450,14 @@ - direct_transformation_of - + immediately transforms from + SIO:000658 - immediately transforms from - SIO:000658 + direct_transformation_of + @@ -4508,7 +4588,7 @@ A light sensing organ composed of ommatidia - FB:gg + FB:gg @@ -7423,7 +7503,7 @@ ncit:Death is an outcome - ncit + ncit @@ -8966,7 +9046,7 @@ 2012-08-23 MP:0005031 trophoblast layer - MP + MP ISBN:0-683-40008-8 @@ -9091,7 +9171,7 @@ bilaminary germ disc - ISBN:9780878932504 + ISBN:9780878932504 @@ -10093,7 +10173,7 @@ in GO lung development is part of respiratory tube development. This can lead to inconsistencies with other ontologies, e.g. VT. The GO structure may be better represented by a tree of tubes (see the FMA class) - GO + GO @@ -11300,6 +11380,16 @@ primitive urogenital sinus http://upload.wikimedia.org/wikipedia/commons/6/6d/Gray1109.png + + + + The ventral part of the cloaca after its separation from the rectum, giving rise to the lower part of the bladder in both sexes, to the prostatic portion of the male urethra, and to the urethra and vestibule in the female. [TFD][VHOG] + 2012-09-17 + VHOG:0000414 + VHOG + + + @@ -11364,16 +11454,6 @@ ISBN:0-683-40008-8 MP:0010116 - - - - The ventral part of the cloaca after its separation from the rectum, giving rise to the lower part of the bladder in both sexes, to the prostatic portion of the male urethra, and to the urethra and vestibule in the female. [TFD][VHOG] - 2012-09-17 - VHOG:0000414 - VHOG - - - @@ -13019,7 +13099,7 @@ The breasts of a female primate's body contain the mammary glands, which secrete milk used to feed infants. Both men and women develop breasts from the same embryological tissues. However, at puberty female sex hormones, mainly estrogens, promote breast development, which does not happen with men. As a result women's breasts become more prominent than men's. - WP,unvetted + WP,unvetted @@ -13085,7 +13165,7 @@ Cartilage pertaining to the tibia. - Dorlands_Medical_Dictionary:MerckSource + Dorlands_Medical_Dictionary:MerckSource @@ -15755,7 +15835,7 @@ VHOG:0000349 VHOG - ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 + ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 @@ -17813,7 +17893,7 @@ ncit has 'hair papilla' as part of hypodermis - ncit + ncit @@ -18315,7 +18395,7 @@ A vein that drains the left pampiniform plexus and empties into the left renal vein. - Dorlands_Medical_Dictionary:MerckSource + Dorlands_Medical_Dictionary:MerckSource @@ -18395,7 +18475,7 @@ A vein that drains the right pampiniform plexus and empties into the inferior vena cava. - Dorlands_Medical_Dictionary:MerckSource + Dorlands_Medical_Dictionary:MerckSource @@ -21976,7 +22056,7 @@ Cranial nerve fiber tract which is comprised of retinal ganglion cell axons running posterior medially towards the optic chiasm, at which some of the axons cross the midline and after which the structure is termed the optic tract. Transmits visual information from the retina to the brain[ZFA]. - ISBN:0471209627 + ISBN:0471209627 ISBN:0471888893 @@ -22331,7 +22411,7 @@ VHOG:0001523 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 @@ -23280,7 +23360,7 @@ A decussation of the diencephalon where the fibers of the optic nerve cross - MGI:llw2 + MGI:llw2 MP:0009770 @@ -24451,7 +24531,7 @@ Paired endochondral long bone that extends between the pectoral girdle and the skeletal parts of the forelimb. [PHENOSCAPE:mah] AAO:0000679 - PHENOSCAPE:mah + PHENOSCAPE:mah @@ -24470,7 +24550,7 @@ VHOG:0001158 VHOG - ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 + ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 @@ -24707,7 +24787,7 @@ VHOG:0000345 VHOG - ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 + ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 @@ -24785,7 +24865,7 @@ The major preaxial endochondral bone in the posterior zeugopod[Phenoscape]. - PHENOSCAPE:mah + PHENOSCAPE:mah @@ -24919,7 +24999,7 @@ 2012-08-14 VSAO:0000186 VSAO - VSAO:NI + VSAO:NI @@ -24938,7 +25018,7 @@ VHOG:0001159 VHOG - ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 + ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 @@ -27395,7 +27475,7 @@ Anatomical system that has as its parts the organs devoted to the ingestion, digestion, and assimilation of food and the discharge of residual wastes. - FB:gg + FB:gg NLM:alimentary+system @@ -27970,7 +28050,7 @@ BIRNLEX:844 ISBN:0-14-051288-8 - ISBN:3110148986 + ISBN:3110148986 NLM:nervous+system WB:rynl ZFIN:curator @@ -28105,7 +28185,7 @@ - FBbt + FBbt cjm @@ -28407,7 +28487,7 @@ - FBbt + FBbt @@ -30712,13 +30792,7 @@ - - - - - - - + @@ -31181,7 +31255,7 @@ 2012-06-20 AAO:0000739 AAO - AAO:Pugener_2002 + AAO:Pugener_2002 @@ -40454,7 +40528,7 @@ the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold MGI:csmith - MGI:rbabiuk + MGI:rbabiuk MP:0008108 @@ -42110,7 +42184,7 @@ the thick outer layer of the adrenal gland that produces and secretes steroid hormones such as corticosterone, estrone and aldosterone ISBN:0-683-40008-8 - MGI:llw2 + MGI:llw2 MP:0008288 @@ -42233,7 +42307,7 @@ the inner portion of the adrenal gland that consists mainly of chromaffin cells which produce, store and secrete neurotransmitters such as epinephrine and norepinephrine MESH:A06.407.071.265 - MGI:llw2 + MGI:llw2 MP:0008289 @@ -50401,7 +50475,7 @@ the area of the frontal lobe that is involved with integration of voluntary movements and with speech.[MP] 2012-08-31 MP:0000800 - MP + MP MGI:csmith @@ -51238,7 +51312,7 @@ 2012-08-14 VSAO:0000027 VSAO - GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 + GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 PSPUB:0000170 @@ -51264,7 +51338,7 @@ GO defines skeletal system very generically: The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton) GO:0001501; however, all annotations are to vertebrates - GO + GO @@ -51570,7 +51644,7 @@ 2012-06-20 AAO:0000742 AAO - AAO:Pugener_2002 + AAO:Pugener_2002 @@ -51855,7 +51929,7 @@ VHOG:0001256 VHOG - ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 + ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 @@ -52016,7 +52090,7 @@ VHOG:0001255 VHOG - ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 + ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 @@ -52260,7 +52334,7 @@ - FMA-modified + FMA-modified @@ -53277,7 +53351,7 @@ VHOG:0000339 VHOG - ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 + ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 @@ -53431,7 +53505,7 @@ - FMA-modified + FMA-modified @@ -53745,7 +53819,7 @@ - FMA-modified + FMA-modified @@ -55173,7 +55247,7 @@ check ncita - ncit + ncit @@ -58894,7 +58968,7 @@ A muscle that attaches to the hyopid bone and to the tongue and is innervated by cranial nerve XII - FEED:rd + FEED:rd @@ -59253,7 +59327,7 @@ A muscle innervated by a facial nerve. - FEED:rd + FEED:rd @@ -59469,7 +59543,7 @@ Nerve that carries information from the olfactory epithelium to the olfactory bulb[Butler and Hodos]. - ISBN:0471209627 + ISBN:0471209627 @@ -59500,7 +59574,7 @@ VHOG:0000703 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 @@ -62007,7 +62081,7 @@ Cranial nerve that has three branches - the ophthalmic (supplying the skin of the nose and upper jaw), the maxillary and the mandibular (supplying the lower jaw). - ISBN:0471209627 + ISBN:0471209627 @@ -62026,7 +62100,7 @@ VHOG:0000704 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 @@ -62245,7 +62319,7 @@ Cranial nerve that branches into the supraorbital (supplying the skin of the eye region and the lateral line organs here), the palatine (to the roof of the buccal cavity), and the hyomandibular (dividing into the jugular and mental branches). - ISBN:0471209627 + ISBN:0471209627 @@ -62264,7 +62338,7 @@ VHOG:0000706 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 @@ -62471,7 +62545,7 @@ Cranial nerve that transmits sound and equilibrium (balance) information from the inner ear to the brain. - ISBN:0471209627 + ISBN:0471209627 @@ -62490,7 +62564,7 @@ VHOG:0000695 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 @@ -62663,7 +62737,7 @@ Cranial nerve that branches into the ramus communicans (to the skin), the pretrematic (to the walls of the pharynx and mouth, viscero-sensory fibers), and the larval post-trematic branch (lost in the adult). - ISBN:0471209627 + ISBN:0471209627 @@ -62682,7 +62756,7 @@ VHOG:0000701 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 @@ -64655,7 +64729,7 @@ in XAO this includes and is only the tympanum - XAO + XAO @@ -66188,7 +66262,7 @@ A muscular organ in the floor of the mouth. - FEED:rd + FEED:rd @@ -66326,7 +66400,7 @@ - FMA-modified + FMA-modified @@ -67543,7 +67617,7 @@ this is an eye appendage in ncit, along with eyelid and eyebrow. in MA, part of eye surface part_of eye - ncit + ncit @@ -68431,7 +68505,7 @@ Cranial nerve that branches into the lateral (to body sense organs) and the intestino-accessorial (to the skin, muscles of shoulder, hyoid, larynx, gut, lungs, and heart). - ISBN:0471209627 + ISBN:0471209627 @@ -68450,7 +68524,7 @@ VHOG:0000737 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 @@ -71481,7 +71555,7 @@ NIFSTD class appears to be retired in nlx[http://neurolex.org/wiki/Nlx_anat_1005030] - NIF + NIF @@ -75884,7 +75958,7 @@ the larger of the two otolith organs in the vestibule - ISBN:0-8036-0655-9 + ISBN:0-8036-0655-9 MGI:smb MP:0006090 @@ -75974,7 +76048,7 @@ the smaller of the two otolith organs in the vestibule - ISBN:0-8036-0655-9 + ISBN:0-8036-0655-9 MGI:smb MP:0006089 @@ -77567,7 +77641,7 @@ VHOG:0000069 VHOG - DOI:10.1016/S0959-4388(99)00003-3 Holland LZ and Holland ND, Chordate origins of the vertebrate central nervous system. Current Opinion in Neurobiology (1999) + DOI:10.1016/S0959-4388(99)00003-3 Holland LZ and Holland ND, Chordate origins of the vertebrate central nervous system. Current Opinion in Neurobiology (1999) @@ -77936,7 +78010,7 @@ endbrain - Swanson:2004 + Swanson:2004 @@ -78100,7 +78174,7 @@ VHOG:0000318 VHOG - DOI:10.1016/S0959-4388(99)00003-3 Holland LZ and Holland ND, Chordate origins of the vertebrate central nervous system. Current Opinion in Neurobiology (1999) + DOI:10.1016/S0959-4388(99)00003-3 Holland LZ and Holland ND, Chordate origins of the vertebrate central nervous system. Current Opinion in Neurobiology (1999) @@ -78138,7 +78212,7 @@ interbrain - Swanson:2004 + Swanson:2004 @@ -79033,7 +79107,7 @@ the epithelial lining of the trachea which contains numerous ciliated cells - ISBN:0-397-51047-0 + ISBN:0-397-51047-0 MGI:cwg MP:0002285 @@ -79680,7 +79754,7 @@ lactiferous gland - FMA:62088 + FMA:62088 @@ -79711,7 +79785,7 @@ lobe of mammary gland - FMA:62088 + FMA:62088 @@ -79881,7 +79955,7 @@ ncit:Milk refers specifically to cow milk - ncit + ncit @@ -85069,7 +85143,7 @@ VHOG:0000982 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 @@ -85312,7 +85386,7 @@ VHOG:0001133 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 @@ -86340,7 +86414,7 @@ VHOG:0000070 VHOG - DOI:10.1016/S0959-4388(99)00003-3 Holland LZ and Holland ND, Chordate origins of the vertebrate central nervous system. Current Opinion in Neurobiology (1999) + DOI:10.1016/S0959-4388(99)00003-3 Holland LZ and Holland ND, Chordate origins of the vertebrate central nervous system. Current Opinion in Neurobiology (1999) @@ -86552,19 +86626,19 @@ papilla mammae - MP:0009723 + MP:0009723 thele - MP:0009723 + MP:0009723 thelium - MP:0009723 + MP:0009723 @@ -87008,7 +87082,7 @@ Part of the metencephalon that lies in the posterior cranial fossa behind the brain stem. It is concerned with the coordination of movement[MESH]. A large dorsally projecting part of the brain concerned especially with the coordination of muscles and the maintenance of bodily equilibrium, situated between the brain stem and the back of the cerebrum , and formed in humans of two lateral lobes and a median lobe[BTO]. Brain structure derived from the anterior hindbrain, and perhaps including posterior midbrain. The cerebellum plays a role in somatic motor function, the control of muscle tone, and balance[ZFA]. BTO:0000232 - ISBN:3764351209 + ISBN:3764351209 MESH:A08.186.211.132.810.428.200 ZFA:0000100 @@ -88235,7 +88309,7 @@ the narrow subcapsular outer zone of the adrenal cortex where aldosterone is produced MESH:A06.407.071.140.960 - MGI:llw2 + MGI:llw2 MP:0008293 @@ -88507,7 +88581,7 @@ assume spelling error for ncit - ncit + ncit @@ -89185,7 +89259,7 @@ - FMA-modified + FMA-modified @@ -89597,7 +89671,7 @@ smooth and glossy outer protective cell layer of hair shaft - MGI:llw2 + MGI:llw2 MP:0003810 @@ -89744,7 +89818,7 @@ VHOG:0000328 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 @@ -89851,7 +89925,7 @@ VHOG:0000369 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 @@ -90452,7 +90526,7 @@ VHOG:0000385 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 @@ -91343,7 +91417,7 @@ in GO, septum morphogenesis is part of cardiac chamber morphogenesis; need to add axioms to infer this - GO + GO @@ -91569,7 +91643,7 @@ VHOG:0000336 VHOG - ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 + ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 @@ -91858,7 +91932,7 @@ VHOG:0000337 VHOG - ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 + ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 @@ -93191,7 +93265,7 @@ The first part of the small intestine. At the junction of the stomach and the duodenum the alimentary canal is inflected. The duodenum first goes anteriorly for a short distance, turns dorsally, and eventually caudally, thus it is a U-shaped structure with two horizontal sections (a ventral and a dorsal one). - ISBN:0815318960 + ISBN:0815318960 @@ -95252,7 +95326,7 @@ the upper conducting airways of the lung; these airways arise from the terminus of the trachea - ISBN:0-397-51047-0 + ISBN:0-397-51047-0 MESH:A04.411.125 MGI:cwg MP:0002264 @@ -95359,7 +95433,7 @@ the conducting airway of the lungs found terminal to the bronchi; these structures contain neither cartilage nor mucous-secreting glands; the epithelium of the bronchioles becomes thinner with each branching - ISBN:0-397-51047-0 + ISBN:0-397-51047-0 MGI:cwg MP:0002267 @@ -95425,7 +95499,7 @@ the last conducting structure of non-respiratory bronchioles; after this point, the airways have alveoli in their walls - ISBN:0-397-51047-0 + ISBN:0-397-51047-0 MGI:cwg MP:0002268 @@ -98181,7 +98255,7 @@ 2012-06-20 AAO:0000545 AAO - AAO:Pugener_2002 + AAO:Pugener_2002 @@ -98705,7 +98779,7 @@ the jelly-like substance in the middle of the spinal disc which is a remnant of the notochord - MGI:llw2 + MGI:llw2 MP:0006392 @@ -98823,7 +98897,7 @@ - EHDAA2-abduced + EHDAA2-abduced @@ -99753,7 +99827,7 @@ The definition was adapted from the NIFSTD class which has been retired. It has been generalized so it is applicable to various different kinds of olfactory tracts found in different taxa. - cjm + cjm ISBN:0471888893 @@ -100168,7 +100242,7 @@ The fluid-filled space separating the membranous from the osseous labyrinth. - Dorlands_Medical_Dictionary:MerckSource + Dorlands_Medical_Dictionary:MerckSource @@ -102066,7 +102140,7 @@ nlx_anat_101177 seems to have been lost in the transition from NIFGA to Neurolex - NIF + NIF https://github.com/SciCrunch/NIF-Ontology/issues/83 @@ -102965,7 +103039,7 @@ - ISBN:0815318960 + ISBN:0815318960 @@ -104943,18 +105017,20 @@ UMLS:C0006382 galen:BundleOfHis AV bundle + AVB His bundle + atrio-ventricular bundle + atrioventricular bundle atrioventricular bundle muscle tissue atrioventricular fasciculus bundle of His fasciculus atrioventricularis uberon A-V bundle - atrio-ventricular bundle UBERON:0002353 - atrioventricular bundle + bundle of His http://upload.wikimedia.org/wikipedia/commons/5/50/ConductionsystemoftheheartwithouttheHeart.png http://upload.wikimedia.org/wikipedia/commons/b/b6/ECG_Principle_fast.gif @@ -104988,6 +105064,18 @@ UMLS:C0006382 ncithesaurus:Atrioventricular_Bundle + + + + AVB + + + + + + atrio-ventricular bundle + EMAPA:35152 + @@ -105020,12 +105108,6 @@ A-V bundle EMAPA:35152 - - - - atrio-ventricular bundle - EMAPA:35152 - @@ -106922,7 +107004,7 @@ - EHDAA2-abduced + EHDAA2-abduced @@ -107557,7 +107639,7 @@ 2012-08-14 VSAO:0000017 VSAO - GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 + GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 PSPUB:0000170 @@ -107783,7 +107865,7 @@ VHOG:0000341 VHOG - ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 + ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 @@ -110387,7 +110469,7 @@ 2012-08-14 VSAO:0000040 VSAO - GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 + GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 PSPUB:0000170 @@ -113684,7 +113766,7 @@ 2012-08-14 VSAO:0000047 VSAO - GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 + GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 PSPUB:0000170 @@ -114099,7 +114181,7 @@ a rough elevation at the middle of the lateral side of the shaft of the humerus to which the deltoid muscle attaches ISBN:0-683-40008-8 - MP:0004353 + MP:0004353 @@ -114112,19 +114194,19 @@ deltoid crest AAO:0000736 - MP:0004353 + MP:0004353 deltoid eminence - MP:0004353 + MP:0004353 deltoid impression - MP:0004353 + MP:0004353 @@ -114163,7 +114245,7 @@ deltoid process - MP:0004353 + MP:0004353 @@ -114656,7 +114738,7 @@ 2012-08-14 VSAO:0000145 VSAO - GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 + GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 PSPUB:0000170 @@ -114869,7 +114951,7 @@ the crystalline particles composed of calcium carbonate and a protein which adhere to the gelatinous membrane of the maculae of the utricle and saccule (otolithic membrane) ISBN:0-683-40008-8 - MGI:llw2 + MGI:llw2 MP:0002894 @@ -115803,8 +115885,8 @@ A line of sensory organs and associated structures along the sides of fish and amphibia that detect vibrations and pressure changes. - ISBN:0471209627 - ISBN:0815318960 + ISBN:0471209627 + ISBN:0815318960 @@ -116545,7 +116627,7 @@ in NIFSTD this is the mereological sum of the individual complexes - in MA it is the superclass - NIF + NIF @@ -116581,6 +116663,158 @@ + + + + + + + + + + + + + + + + + The corticospinal fibers that arise from the pyramidal cells within the cerebral cortex layer V of the precentral motor area, the premotor area and the postcentral gyrus, then descend into and through the medulla to form the lateral corticospinal tract and the anterior corticospinal tract. + UBERON:0004095 + pyramidal tract + + + + + + BAMS:P + BIRNLEX:1464 + BM:CST + BM:Me-PyT + DHBA:12776 + DMBA:17756 + EMAPA:36600 + FMA:72634 + GAID:702 + HBA:265505574 + MBA:190 + MBA:784 + MESH:D011712 + UMLS:C0034229 + http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=800 + corticospinal fibers + fasciculus cerebro-spinalis + fasciculus pyramidalis + fibrae corticospinales + pyramid (Willis) + tractus cortico-spinalis + tractus corticospinalis + tractus pyramidalis + uberon + UBERON:0002707 + + + corticospinal tract + http://upload.wikimedia.org/wikipedia/commons/a/ac/Gray684.png + + + + + + In NIFSTD this is a tract of brain but this leads to issues due to its overlap with the spinal cord + + + + + The corticospinal fibers that arise from the pyramidal cells within the cerebral cortex layer V of the precentral motor area, the premotor area and the postcentral gyrus, then descend into and through the medulla to form the lateral corticospinal tract and the anterior corticospinal tract. + ISBN:0-683-40008-8 + MP:0002878 + + + + + pyramidal tract + + BIRNLEX:1464 + MP:0002878 + + + + + + UMLS:C0034229 + BIRNLEX:1464 + + + + + http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=800 + BIRNLEX:1464 + + + + + corticospinal fibers + NeuroNames:1320 + + + + + fasciculus cerebro-spinalis + NeuroNames:1320 + + + + + + fasciculus pyramidalis + NeuroNames:800 + + + + + + fibrae corticospinales + NeuroNames:1320 + + + + + + pyramid (Willis) + NeuroNames:800 + + + + + tractus cortico-spinalis + NeuroNames:1320 + + + + + + tractus corticospinalis + + + + + + + tractus corticospinalis + NeuroNames:1320 + + + + + + tractus pyramidalis + NeuroNames:800 + + + + + @@ -118256,7 +118490,7 @@ massive inconsistencies between GO, MA, wikipedia. Part of pons in MA, but this leads to inconsistencies with ABA. - GO + GO https://github.com/obophenotype/mouse-anatomy-ontology/issues/58 @@ -119377,7 +119611,7 @@ A temporary epithelium that derives from the outer layer of the ectdoerm and is shed once the inner layer differentiates to form a true epidermis. - ISBN:9780878932504 + ISBN:9780878932504 @@ -120244,7 +120478,7 @@ in XAO, develops from visceral pouch 2 - XAO + XAO @@ -120721,7 +120955,7 @@ TODO - check that GO's optic placode is the same as ZFA's eye primordium; we may want to have separate term for ocular primordium precursor. XAO has both optic field and eye primordium. - GO + GO @@ -121216,7 +121450,7 @@ A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA] - ISBN:0815318960 + ISBN:0815318960 OMD:neural+plate ZFIN:curator @@ -121427,7 +121661,7 @@ somitic mesoderm - ISBN:9780878932504 + ISBN:9780878932504 @@ -121507,7 +121741,7 @@ - EHDAA2-abduced + EHDAA2-abduced @@ -121544,7 +121778,7 @@ in XAO this develops_from dorsolateral placode, but in NBK53175, this is a separate group - XAO + XAO @@ -121821,7 +122055,7 @@ - EHDAA2-abduced + EHDAA2-abduced @@ -121907,7 +122141,7 @@ Trunk portion of the neural crest. The trunk neural crest lies between the vagal and sacral neural crest and gives rise to two groups of cells. One group migrates dorsolateral and populates the skin, forming pigment cells and the other migrates ventrolateral through the anterior sclerotome to become the epinephrine-producing cells of the adrenal gland and the neurons of the sympathetic nervous system. Some cells remain in the sclerotome to form the dorsal root ganglia [Wikipedia]. - ISBN:0815318960 + ISBN:0815318960 @@ -121990,7 +122224,7 @@ - Obol + Obol @@ -122248,7 +122482,7 @@ part_of somite in XAO - XAO + XAO @@ -123145,7 +123379,7 @@ 2012-06-20 AAO:0010365 AAO - ISBN:0-02-377110-0 + ISBN:0-02-377110-0 @@ -123161,7 +123395,7 @@ in XAO, called branchial arch 1 and df VP3 - XAO + XAO @@ -123257,7 +123491,7 @@ 2012-06-20 AAO:0010366 AAO - ISBN:0-02-377110-0 + ISBN:0-02-377110-0 @@ -123273,7 +123507,7 @@ in XAO, called branchial arch 2 and df VP4 - XAO + XAO @@ -123371,7 +123605,7 @@ 2012-06-20 AAO:0010368 AAO - ISBN:0-02-377110-0 + ISBN:0-02-377110-0 @@ -123642,7 +123876,7 @@ 2012-06-20 AAO:0010418 AAO - ISBN:0-02-377110-0 + ISBN:0-02-377110-0 @@ -123779,7 +124013,7 @@ 2012-06-20 AAO:0010419 AAO - ISBN:0-02-377110-0 + ISBN:0-02-377110-0 @@ -123905,7 +124139,7 @@ 2012-06-20 AAO:0010420 AAO - ISBN:0-02-377110-0 + ISBN:0-02-377110-0 @@ -124038,7 +124272,7 @@ 2012-06-20 AAO:0010422 AAO - ISBN:0-02-377110-0 + ISBN:0-02-377110-0 @@ -124671,7 +124905,7 @@ GO uses genitalia for the singular organ - GO + GO @@ -126995,7 +127229,7 @@ amnionic ectoderm - ISBN:9780878932504 + ISBN:9780878932504 @@ -150500,7 +150734,7 @@ Fibrous joint in which the articulating bones or cartilages of the skull are connected by sutural ligaments (scant amount of collagenous dense connective tissue). Examples: sagittal suture, frontal suture. FMA:71385 - ISBN:3110148986 + ISBN:3110148986 @@ -151394,7 +151628,7 @@ - FMA-modified + FMA-modified @@ -151410,7 +151644,7 @@ - FMA-modified + FMA-modified @@ -152737,7 +152971,7 @@ VHOG:0000343 VHOG - ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 + ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 @@ -152921,7 +153155,7 @@ VHOG:0000348 VHOG - ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 + ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 @@ -155611,7 +155845,7 @@ Mesenchyme enclosed by dental organ.[MP] - MP + MP J:153554 @@ -155928,7 +156162,7 @@ 2012-06-20 AAO:0000725 AAO - AAO:Pugener_2002 + AAO:Pugener_2002 @@ -159540,6 +159774,7 @@ The funnel-like expansion of the abdominal extremity of the uterine tube[MP] The third part of the uterine tube is the infundibulum. It terminates with the ostium of Fallopian tube, surrounded by fimbriae, one of which is attached to the ovary[Wikipedia:Infundibulum_of_uterine_tube]. + In mammals, the uterine tube infundibulum is part of the fallopian tube. In birds, where there is no fallopian tube, the uterine tube infundibulum is part of the oviduct. infundibulum @@ -159574,6 +159809,12 @@ The third part of the uterine tube is the infundibulum. It terminates with the ostium of Fallopian tube, surrounded by fimbriae, one of which is attached to the ovary[Wikipedia:Infundibulum_of_uterine_tube]. + + + + In mammals, the uterine tube infundibulum is part of the fallopian tube. In birds, where there is no fallopian tube, the uterine tube infundibulum is part of the oviduct. + + @@ -159937,7 +160178,7 @@ - EHDAA2-abduced + EHDAA2-abduced @@ -160013,7 +160254,7 @@ - NCBIBook:NBK10047 + NCBIBook:NBK10047 @@ -160032,13 +160273,186 @@ germinal neuroepithelium - NCBIBook:NBK10047 + NCBIBook:NBK10047 original neural tube - NCBIBook:NBK10047 + NCBIBook:NBK10047 + + + + + + + + + + + + + + + The transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles[MP]. + contributes significantly in building up the GABAergic cortical cell population[WP] + GE + SVZ + embryonic GE + embryonic SVZ + subventricular zone + + DHBA:10549 + EMAPA:32665 + PBA:128012818 + embryonic subventricular zone + embryonic/fetal subventricular zone + fetal subventricular zone + subependymal layer + uberon + UBERON:0004023 + + ganglionic eminence + + + + + The transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles[MP]. + MP:0004274 + + + + + GE + + + + + + SVZ + MP:0004274 + + + + + + embryonic GE + + + + + + embryonic SVZ + + + + + + subventricular zone + DHBA:SZ + + + + + embryonic subventricular zone + MP:0004274 + + + + + subependymal layer + MP:0004274 + + + + + + + + + + + + + + + + + + + + + A distinct elevation of a transient proliferating cell mass of the fetal subventricular zone; this mass contributes most of its cells to the neocortex; however, hippocampal neurons, thalamus, septum and olfactory bulb neurons are also partly derived from the MGE. + MGE + DHBA:10550 + EMAPA:37471 + PBA:128012834 + uberon + UBERON:0004024 + + medial ganglionic eminence + + + + + A distinct elevation of a transient proliferating cell mass of the fetal subventricular zone; this mass contributes most of its cells to the neocortex; however, hippocampal neurons, thalamus, septum and olfactory bulb neurons are also partly derived from the MGE. + MP:0004276 + + + + + MGE + + + + + + + EMAPA:37471 + MA:th + + + + + + + + + + + + + + + + + + + + + The caudally located, distinct elevation of a transient proliferating cell mass of the fetal subventricular zone, located adjacent to the lateral ventricle + CGE + DHBA:10552 + EFO:0001911 + EMAPA:37469 + PBA:128012846 + uberon + UBERON:0004026 + + + caudal ganglionic eminence + + + + + The caudally located, distinct elevation of a transient proliferating cell mass of the fetal subventricular zone, located adjacent to the lateral ventricle + MP:0004278 + + + + + EMAPA:37469 + MA:th @@ -160712,7 +161126,7 @@ - NCBIBook:NBK10047 + NCBIBook:NBK10047 @@ -160723,7 +161137,7 @@ - NCBIBook:NBK10047 + NCBIBook:NBK10047 @@ -160742,19 +161156,19 @@ ependymal layer - NCBIBook:NBK10047 + NCBIBook:NBK10047 neural tube ependymal layer - NCBIBook:NBK10047 + NCBIBook:NBK10047 neural tube ventricular germinal zone - NCBIBook:NBK10047 + NCBIBook:NBK10047 @@ -160816,7 +161230,7 @@ - NCBIBook:NBK10047 + NCBIBook:NBK10047 @@ -160828,7 +161242,7 @@ by division - NCBIBook:NBK10047 + NCBIBook:NBK10047 @@ -163263,7 +163677,7 @@ this term denotes the primary heart field; GO:0003128 denotes the superclass of primary and secondary: specific region of the lateral mesoderm into the area which will form the primary beating heart tube[GO:0003138] - GO + GO @@ -163500,6 +163914,8 @@ the intraventricular conduction system from the bundle of His to the distal Purkinje fibers, which carries the impulse to the ventricles. HPS His-Purkinji network + VCS + ventricular conduction system uberon UBERON:0004146 His-Purkinje system @@ -164742,7 +165158,7 @@ NIF divides this into main and accessory - NIF + NIF @@ -172546,7 +172962,7 @@ 2012-08-14 VSAO:0000026 VSAO - GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 + GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 @@ -173882,7 +174298,7 @@ An outgrowth on the lateral trunk of the embryo that develops into a limb or paired fin. The limb/fin bud is divided into ectoderm and mesenchyme[cjm, modified from MP]. - ISBN:9780878932504 + ISBN:9780878932504 MP:0005650 @@ -174126,7 +174542,7 @@ One of a series of paired embryological vascular structures formed within a pharyngeal arch; in the adult, some of these vessels give rise to the great vessels[MP] - MP:0002672 + MP:0002672 @@ -174146,7 +174562,7 @@ VHOG:0000122 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 @@ -174158,7 +174574,7 @@ PAA - MP:0002672 + MP:0002672 @@ -174192,13 +174608,13 @@ embryonic aortic arch artery EMAPA:16684 - MP:0002672 + MP:0002672 pharyngeal arch artery - MP:0002672 + MP:0002672 @@ -174932,7 +175348,7 @@ 2012-08-14 VSAO:0000300 VSAO - GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 + GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 @@ -176191,7 +176607,7 @@ it's not clear if the XAO class belongs here or below - XAO + XAO @@ -178309,7 +178725,7 @@ in GO, this is equivalent to the atrial myocardium, but FMA distinguishes these two. Consider merging. - GO + GO @@ -184849,7 +185265,7 @@ GO treats glomus and pronephric glomerulus differently - GO + GO @@ -184999,7 +185415,7 @@ 2012-08-14 TAO:0000191 TAO - TAO:GA_TG + TAO:GA_TG @@ -185140,7 +185556,7 @@ 2012-08-14 TAO:0001455 TAO - TAO:GA_TG + TAO:GA_TG ZFIN:curator @@ -185238,7 +185654,7 @@ VSAO:0000015 taken from version of VSAO used in TAO and used directly in Uberon VSAO - GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 + GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 PSPUB:0000170 @@ -191706,7 +192122,7 @@ parietal mesoderm - ISBN:9780878932504 + ISBN:9780878932504 @@ -191766,7 +192182,7 @@ splanchnic mesoderm - ISBN:9780878932504 + ISBN:9780878932504 @@ -193415,7 +193831,7 @@ The tissue underlying the tunica mucosa of the pharynx. - BTO:0002113 + BTO:0002113 FMA:75144 pharyngeal submucosa pharynx submucosa @@ -193432,7 +193848,7 @@ The tissue underlying the tunica mucosa of the pharynx. - BTO:0002113 + BTO:0002113 @@ -193458,20 +193874,20 @@ tela submucosa pharyngis - BTO:0002113 + BTO:0002113 submucous coat of pharynx - BTO:0002113 + BTO:0002113 submucous layer of pharynx - BTO:0002113 + BTO:0002113 @@ -202374,7 +202790,7 @@ in GO, covers optic, otic, olfactory, mammary, hair, tooth, sebaceous - and also insect structures - GO + GO @@ -202464,7 +202880,7 @@ hair gem - ISBN:9780878932504 + ISBN:9780878932504 @@ -202476,7 +202892,7 @@ hair peg - ISBN:9780878932504 + ISBN:9780878932504 @@ -205872,7 +206288,7 @@ EHDAA2:0001056 EHDAA:6524 EMAPA:36633 - FMA:62088 + FMA:62088 MA:0000797 breast mammary gland uberon @@ -205903,14 +206319,14 @@ lactiferous gland - FMA:62088 + FMA:62088 mammary gland - FMA:62088 + FMA:62088 @@ -207650,7 +208066,7 @@ Portion of primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells. - ISBN:0683400088 + ISBN:0683400088 MP:0011260 @@ -209982,7 +210398,7 @@ XAO/AAO class belongs here, as it refers to mesonephric structure - XAO + XAO @@ -210537,7 +210953,7 @@ - NCBIBook:NBK10047 + NCBIBook:NBK10047 @@ -210863,7 +211279,7 @@ Layer that is part of the CA fields of the hippocampus consisting of a narrow relatively cell free layer located deep to the pyramidal cell layer extending through areas CA1, CA2 and CA3. (adapted from Paxinos The rat central nervous system, 2nd ed, Academic Press, San Diego, 1995) BAMS:Or - BIRNLEX:4113 + BIRNLEX:4113 EMAPA:35412 FMA:83893 MA:0000958 @@ -210884,43 +211300,43 @@ Layer that is part of the CA fields of the hippocampus consisting of a narrow relatively cell free layer located deep to the pyramidal cell layer extending through areas CA1, CA2 and CA3. (adapted from Paxinos The rat central nervous system, 2nd ed, Academic Press, San Diego, 1995) - BIRNLEX:4113 + BIRNLEX:4113 http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=157 - BIRNLEX:4113 + BIRNLEX:4113 oriens layer of hippocampus - BIRNLEX:4113 + BIRNLEX:4113 oriens layer of the hippocampus - BIRNLEX:4113 + BIRNLEX:4113 polymorphic layer of hippocampus - BIRNLEX:4113 + BIRNLEX:4113 polymorphic layer of the hippocampus - BIRNLEX:4113 + BIRNLEX:4113 stratum oriens - BIRNLEX:4113 + BIRNLEX:4113 @@ -211748,6 +212164,653 @@ + + + + + + + + + + + + + + + + + Layer of neocortex lying just deep to molecular layer characterized by numerous small cell bodies. + + + ABA:CTX2 + EMAPA:35256 + FMA:77804 + MA:0000898 + NCIT:C32557 + NLXANAT:090808 + PBA:294021800 + UMLS:C1517039 + cerebral cortex, layer 2 + external granular layer of isocortex [layer II] + external granular layer of neocortex + external granule cell layer of neocortex + lamina granularis externa isocorticis [lamina ii] + layer II of neocortex + neocortex layer 2 + neocortex layer II + uberon + EGL + external granular cell layer + external granular layer + external granular layer of cerebral cortex + external granule cell layer + granule cell layer of cerebral cortex + UBERON:0005391 + cortical layer II + + + + + + + + + + + BRAINSPAN + + + + + Layer of neocortex lying just deep to molecular layer characterized by numerous small cell bodies. + NLXANAT:090808 + + + + + UMLS:C1517039 + ncithesaurus:External_Granular_Layer + + + + + cerebral cortex, layer 2 + ABA:CTX2 + + + + + external granular layer of isocortex [layer II] + FMA:77804 + + + + + external granular layer of neocortex + FMA:77804 + + + + + external granule cell layer of neocortex + NLXANAT:090808 + + + + + lamina granularis externa isocorticis [lamina ii] + FMA:77804 + FMA:TA + + + + + + layer II of neocortex + NLXANAT:090808 + + + + + neocortex layer 2 + NLXANAT:090808 + + + + + neocortex layer II + NLXANAT:090808 + + + + + EGL + + + + + + + + + + + + + + + + + + + + + + Layer of neocortex lying deep to the external granule cell layer defined cytoarchitecturally by numerous small pyramidal neurons. + + + ABA:CTX3 + EMAPA:35257 + FMA:77810 + MA:0000899 + NCIT:C32571 + NLXANAT:090809 + PBA:294021824 + UMLS:C1517046 + cerebral cortex, layer 3 + external pyramidal cell layer + external pyramidal cell layer of neocortex + external pyramidal layer of isocortex [layer iii] + external pyramidal layer of neocortex + lamina pyramidalis externa isocorticis [lamina iii] + layer 3 of neocortex + layer III of neocortex + neocortex external pyramidal cell layer + neocortex layer 3 + neocortex layer III + uberon + external pyramidal layer of cerebral cortex + isocortex, deep supragranular pyramidal layer + lamina pyramidalis externa + layer of medium-sized and large pyramidal cells + pyramidal layer + UBERON:0005392 + cortical layer III + + + + + + + + + + + BRAINSPAN + + + + + Layer of neocortex lying deep to the external granule cell layer defined cytoarchitecturally by numerous small pyramidal neurons. + NLXANAT:090809 + + + + + UMLS:C1517046 + ncithesaurus:External_Pyramidal_Cell_Layer + + + + + cerebral cortex, layer 3 + ABA:CTX3 + + + + + external pyramidal cell layer + FMA:77810 + + + + + external pyramidal cell layer of neocortex + NLXANAT:090809 + + + + + external pyramidal layer of isocortex [layer iii] + FMA:77810 + + + + + external pyramidal layer of neocortex + FMA:77810 + + + + + lamina pyramidalis externa isocorticis [lamina iii] + FMA:77810 + FMA:TA + + + + + + layer 3 of neocortex + NLXANAT:090809 + + + + + layer III of neocortex + NLXANAT:090809 + + + + + neocortex external pyramidal cell layer + NLXANAT:090809 + + + + + neocortex layer 3 + NLXANAT:090809 + + + + + neocortex layer III + NLXANAT:090809 + + + + + external pyramidal layer of cerebral cortex + ncithesaurus:External_Pyramidal_Cell_Layer + + + + + isocortex, deep supragranular pyramidal layer + NeuroNames:2448 + + + + + lamina pyramidalis externa + NeuroNames:2448 + + + + + + layer of medium-sized and large pyramidal cells + NeuroNames:2448 + + + + + + + + + + + + + + + + + + + + + Layer of neocortex lying deep to the external pyramidal cell layer defined cytoarchitecturally by the presence of numerous small cells + ... + Relatively undeveloped in some mammals such as the tenrec. + + + ABA:CTX4 + EMAPA:35258 + FMA:77811 + MA:0000900 + NCIT:C32844 + NLXANAT:090810 + PBA:294021852 + UMLS:C1512872 + cerebral cortex, layer 4 + internal granular layer of isocortex [layer iv] + internal granular layer of neocortex + internal granule cell layer of neocortex + lamina granularis interna isocorticis [lamina iv] + layer 4 of neocortex + layer IV of neocortex + neocortex internal granule cell layer + neocortex layer 4 + neocortex layer IV + neocortical internal granule cell layer + neocortical layer IV + uberon + internal granular layer + UBERON:0005393 + cortical layer IV + + + + + + + + + + + BRAINSPAN + + + + + Layer of neocortex lying deep to the external pyramidal cell layer defined cytoarchitecturally by the presence of numerous small cells + NLXANAT:090810 + + + + + ... + + + + + + Relatively undeveloped in some mammals such as the tenrec. + ISBN:0471888893 + + + + + UMLS:C1512872 + ncithesaurus:Internal_Granular_Layer + + + + + cerebral cortex, layer 4 + ABA:CTX4 + + + + + internal granular layer of isocortex [layer iv] + FMA:77811 + + + + + internal granular layer of neocortex + FMA:77811 + + + + + internal granule cell layer of neocortex + NLXANAT:090810 + + + + + lamina granularis interna isocorticis [lamina iv] + FMA:77811 + FMA:TA + + + + + + layer 4 of neocortex + NLXANAT:090810 + + + + + layer IV of neocortex + NLXANAT:090810 + + + + + neocortex internal granule cell layer + NLXANAT:090810 + + + + + neocortex layer 4 + NLXANAT:090810 + + + + + neocortex layer IV + NLXANAT:090810 + + + + + neocortical internal granule cell layer + NLXANAT:090810 + + + + + neocortical layer IV + NLXANAT:090810 + + + + + + + + + + + + + + + + + + + + + Layer of neocortex lying deep to the internal granule cell layer (layer 4) defined cytoarchitecturally by the predominance of large pyramidal cell bodies + + + ABA:CTX5 + EMAPA:35259 + FMA:77812 + MA:0000901 + NCIT:C32653 + NLXANAT:090811 + PBA:294021878 + UMLS:C1517447 + betz' cells + cerebral cortex, layer 5 + internal pyramidal cell layer of neocortex + internal pyramidal layer of isocortex [layer v] + internal pyramidal layer of neocortex + lamina pyramidalis interna isocorticis [lamina v] + layer 5 of neocortex + layer V of neocortex + neocortex internal pyramidal cell layer + neocortex layer 5 + neocortex layer V + neocortical layer 5 + neocortical layer V + uberon + deep layer of large pyramidal cells + ganglionic layer + ganglionic layer of cerebral cortex + inner layer of large pyramidal cells + internal pyramidal layer + isocortex, infragranular pyramidal layer + lamina ganglionaris + lamina pyramidalis interna + UBERON:0005394 + cortical layer V + + + + + + + + + + + BRAINSPAN + + + + + Layer of neocortex lying deep to the internal granule cell layer (layer 4) defined cytoarchitecturally by the predominance of large pyramidal cell bodies + NLXANAT:090811 + + + + + UMLS:C1517447 + ncithesaurus:Ganglionic_Layer + + + + + betz' cells + FMA:77812 + + + + + cerebral cortex, layer 5 + ABA:CTX5 + + + + + internal pyramidal cell layer of neocortex + NLXANAT:090811 + + + + + internal pyramidal layer of isocortex [layer v] + FMA:77812 + + + + + internal pyramidal layer of neocortex + FMA:77812 + + + + + lamina pyramidalis interna isocorticis [lamina v] + FMA:77812 + FMA:TA + + + + + + layer 5 of neocortex + NLXANAT:090811 + + + + + layer V of neocortex + NLXANAT:090811 + + + + + neocortex internal pyramidal cell layer + NLXANAT:090811 + + + + + neocortex layer 5 + NLXANAT:090811 + + + + + neocortex layer V + NLXANAT:090811 + + + + + neocortical layer 5 + NLXANAT:090811 + + + + + neocortical layer V + NLXANAT:090811 + + + + + deep layer of large pyramidal cells + NeuroNames:2450 + + + + + inner layer of large pyramidal cells + NeuroNames:2450 + + + + + internal pyramidal layer + NeuroNames:2450 + + + + + isocortex, infragranular pyramidal layer + NeuroNames:2450 + + + + + lamina ganglionaris + NeuroNames:2450 + + + + + + lamina pyramidalis interna + NeuroNames:2450 + + + + + @@ -212904,7 +213967,7 @@ VHOG:0001260 VHOG - ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 + ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 @@ -213586,7 +214649,7 @@ - Obol + Obol @@ -215335,7 +216398,7 @@ VHOG:0001372 VHOG - DOI:10.1016/S0959-4388(99)00003-3 Holland LZ and Holland ND, Chordate origins of the vertebrate central nervous system. Current Opinion in Neurobiology (1999) + DOI:10.1016/S0959-4388(99)00003-3 Holland LZ and Holland ND, Chordate origins of the vertebrate central nervous system. Current Opinion in Neurobiology (1999) @@ -215693,7 +216756,7 @@ - Obol + Obol @@ -216258,7 +217321,7 @@ we place the XAO structure here for now. In terms of analagy, it is more closely related to common iliac, but the relationships currently attached to this class are mammal specific - XAO + XAO @@ -218719,7 +219782,7 @@ A ring of cells capable of forming a limb. - ISBN:9780878932504 + ISBN:9780878932504 @@ -219105,7 +220168,7 @@ The short canal through the orbitosphenoid bone at the apex of the orbit that gives passage to the optic nerve and the opthalmic artery MP:0010704 - MP + MP @@ -220327,7 +221390,7 @@ VHOG:0000264 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 @@ -221637,7 +222700,7 @@ embryonic anlage of the external genitalia, which emerges as paired swellings ventral to the cloacal membrane, is proposed to be derived from all three germ layers, and gives rise to the penis, clitoris, scrotum, labia, and foreskin; GT development is indistinguishable in male and female mouse embryos until ~E16, when the urethral plate begins to be masculinized to form the penile urethra, marking the beginning of an androgen-dependent phase of sexual differentiation[MP] - MP + MP @@ -223172,7 +224235,7 @@ Anteriosuperior, smooth-walled portion of the cavity of the right ventricle, beginning at the supraventricular crest and terminating in the pulmonary trunk - MP:0010428 + MP:0010428 @@ -223196,7 +224259,7 @@ RVOT - MP:0010428 + MP:0010428 @@ -223215,7 +224278,7 @@ infundibulum of right ventricle - MP:0010428 + MP:0010428 @@ -223233,37 +224296,37 @@ right ventricle pulmonary outflow tract - MP:0010428 + MP:0010428 right ventricular outflow tract - MP:0010428 + MP:0010428 arterial cone - MP:0010428 + MP:0010428 conus arteriosus - MP:0010428 + MP:0010428 pulmonary cone - MP:0010428 + MP:0010428 pulmonary conus - MP:0010428 + MP:0010428 @@ -223904,8 +224967,10 @@ EMAPA:37358 FMA:9487 galen:LeftBundleBranch + LBB crus sinistrum (fasciculi atrioventricularis) crus sinistrum fasciculi atrioventricularis + left branch of atrioventricular bundle left bundle branch left bundle branch of bundle of His left bundle of atrioventricular bundle @@ -223915,13 +224980,13 @@ uberon UBERON:0005986 - left branch of atrioventricular bundle + left bundle branch The left branch of the atrioventricular bundle that separates at the bundle of His, descends the septal wall of the left ventricle and connects to the terminal Purkinje fiber[MP]. - MP:0010566 + MP:0010566 @@ -223929,6 +224994,12 @@ EMAPA:37358 MA:th + + + + LBB + + @@ -223947,7 +225018,7 @@ left bundle branch - MP:0010566 + MP:0010566 @@ -223959,25 +225030,25 @@ left bundle of atrioventricular bundle - MP:0010566 + MP:0010566 left crus of atrioventricular bundle - MP:0010566 + MP:0010566 left posterior branch - MP:0010566 + MP:0010566 left posterior bundle - MP:0010566 + MP:0010566 @@ -224005,8 +225076,10 @@ EMAPA:37359 FMA:9486 galen:RightBundleBranch + RBB crus dextrum (fasciculi atrioventricularis) crus dextrum fasciculi atrioventricularis + right branch of atrioventricular bundle right bundle right bundle branch right bundle branch of bundle of His @@ -224015,7 +225088,7 @@ uberon UBERON:0005987 - right branch of atrioventricular bundle + right bundle branch @@ -224029,6 +225102,12 @@ EMAPA:37359 MA:th + + + + RBB + + @@ -224761,7 +225840,7 @@ We follow XAO is distinguishing the tail region from the tail; the tail bud is part of the tail region; the tail starts after the tail bud - XAO + XAO @@ -227050,27 +228129,17 @@ - - - - - - - + + - - - - - - - + + - + @@ -227079,24 +228148,14 @@ - - - - - - - + + - - - - - - - + + An anatomical junctions that overlaps the foregut and midgut. @@ -227447,7 +228506,7 @@ A sac-like cavity ventral to the liver, lying in the sub-mesodermal space and closed by a thin sheet of ectodermal cells, from which the future gall bladder develops. - ISBN:0815318960 + ISBN:0815318960 XAO:0004205 @@ -228518,7 +229577,7 @@ - EHDAA2-abduced + EHDAA2-abduced ZFA @@ -229612,7 +230671,7 @@ A ring of fibrous or fibrocartilaginous tissue (as of an intervertebral disk or surrounding an orifice of the heart). anulus - BTO:0003627 + BTO:0003627 EMAPA:32670 FMA:76704 anulus fibrosus @@ -229627,13 +230686,13 @@ A ring of fibrous or fibrocartilaginous tissue (as of an intervertebral disk or surrounding an orifice of the heart). - BTO:0003627 + BTO:0003627 anulus - BTO:0003627 + BTO:0003627 @@ -229651,7 +230710,7 @@ fibrous ring - BTO:0003627 + BTO:0003627 @@ -230818,18 +231877,18 @@ - + - + - + @@ -230838,13 +231897,13 @@ - + - + @@ -233287,7 +234346,7 @@ 2012-08-14 VSAO:0005019 VSAO - VSAO:NI + VSAO:NI @@ -233318,7 +234377,7 @@ autopodium VSAO:0005019 - VSAO:NI + VSAO:NI @@ -237168,7 +238227,7 @@ The distal part of adenohypophysis: the part that makes up the main body of the gland. - Dorlands_Medical_Dictionary:MerckSource + Dorlands_Medical_Dictionary:MerckSource @@ -238620,7 +239679,7 @@ Portion of tissue that consists of the precursors of the pronephric glomus or glomerulus; derived from the medial portion of the pronephric intermediate mesoderm. - ISBN:0815318960 + ISBN:0815318960 @@ -242868,7 +243927,7 @@ - Obol + Obol @@ -244436,14 +245495,14 @@ - FBbt + FBbt AEO - FBbt + FBbt @@ -246587,7 +247646,7 @@ 2012-08-14 VSAO:0000023 VSAO - GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 + GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 PSPUB:0000170 @@ -246817,7 +247876,7 @@ 2012-08-14 VSAO:0000050 VSAO - GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 + GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 PSPUB:0000170 @@ -251004,7 +252063,7 @@ 2012-08-14 VSAO:0000046 VSAO - GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 + GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 PSPUB:0000170 @@ -251091,7 +252150,7 @@ - Obol + Obol @@ -251996,7 +253055,7 @@ A retinal neural layer that is immediately adjacent to the inner nuclear layer and comprises 20 percent of the inner plexiform layer of retina. - GOC:tfm + GOC:tfm @@ -252047,7 +253106,7 @@ A retinal neural layer that is immediately adjacent to the S1 and S3 layers and comprises 20 percent of the inner plexiform layer of retina. - GOC:tfm + GOC:tfm @@ -252099,7 +253158,7 @@ A retinal neural layer that is immediately adjacent to the S2 and S4 layers and comprises 20 percent of the inner plexiform layer of retina. - GOC:tfm + GOC:tfm @@ -252150,7 +253209,7 @@ A retinal neural layer that is immediately adjacent to the S3 and S5 layer and comprises 20 percent of the inner plexiform layer of retina. - GOC:tfm + GOC:tfm @@ -252198,7 +253257,7 @@ A retinal neural layer that is immediately adjacent to the retinal ganglion cell layer and comprises 20 percent of the ganglion plexiform layer of retina. - GOC:tfm + GOC:tfm @@ -252234,7 +253293,7 @@ One of sublaminar layers S1 or S2. - GOC:tfm + GOC:tfm @@ -252270,7 +253329,7 @@ One of sublaminar layers S2 or S3. - GOC:tfm + GOC:tfm @@ -252306,7 +253365,7 @@ One of sublaminar layers S4 or S5. - GOC:tfm + GOC:tfm @@ -252417,7 +253476,7 @@ - Obol + Obol @@ -260936,6 +261995,7 @@ + @@ -260985,11 +262045,13 @@ - outer portion of the renal cortex. Site of formation of medullary and cortical elements. + Outer portion of the renal cortex. Site of formation of medullary and cortical elements. see http://www.ncbi.nlm.nih.gov/pubmed/12761251 for description of nephrogenic zone in dogfish. EMAPA:27721 MA:0002996 + cortical nephrogenic niche + cortical nephrogenic zone uberon nephrogenic tissue UBERON:0009871 @@ -260999,9 +262061,21 @@ - outer portion of the renal cortex. Site of formation of medullary and cortical elements. + Outer portion of the renal cortex. Site of formation of medullary and cortical elements. + + + + cortical nephrogenic niche + + + + + + cortical nephrogenic zone + + @@ -261162,7 +262236,7 @@ 2012-08-14 VSAO:0005022 VSAO - VSAO:NI + VSAO:NI @@ -261177,7 +262251,7 @@ basipodium skeleton VSAO:0005022 - VSAO:NI + VSAO:NI @@ -261202,14 +262276,14 @@ basipodium VSAO:0005022 - VSAO:NI + VSAO:NI mesopodium VSAO:0005022 - VSAO:NI + VSAO:NI @@ -263540,7 +264614,7 @@ - FBbt + FBbt @@ -265719,7 +266793,7 @@ in ncit, seminal fluid is a subtype of seminal vesicle secretion - ncit + ncit @@ -266638,7 +267712,7 @@ isa blood vessel in XAO - XAO + XAO @@ -268773,7 +269847,7 @@ - EHDAA2-abduced + EHDAA2-abduced @@ -272524,7 +273598,7 @@ 2012-08-14 VSAO:0005025 VSAO - VSAO:NI + VSAO:NI @@ -272565,7 +273639,7 @@ metapodium VSAO:0005025 - VSAO:NI + VSAO:NI @@ -273461,7 +274535,7 @@ antebrachium skeleton - PHENOSCAPE:ni + PHENOSCAPE:ni @@ -273566,7 +274640,7 @@ 2012-08-14 VSAO:0000214 VSAO - GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 + GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 @@ -273967,7 +275041,7 @@ 2012-08-14 VSAO:0000302 VSAO - GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 + GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 @@ -274069,13 +275143,13 @@ crus skeleton - PHENOSCAPE:ni + PHENOSCAPE:ni skeleton cruris - NominaAnatomicaVeterinaria:2005 + NominaAnatomicaVeterinaria:2005 @@ -278537,7 +279611,7 @@ - EHDAA2-abduced + EHDAA2-abduced @@ -278902,13 +279976,13 @@ - FBbt + FBbt - FBbt + FBbt @@ -280017,7 +281091,7 @@ 2012-08-14 VSAO:0000301 VSAO - GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 + GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 @@ -280102,7 +281176,7 @@ 2012-08-14 VSAO:0005007 VSAO - VSAO:NI + VSAO:NI @@ -284209,7 +285283,7 @@ A segment of the autopod consisting of both acropodial region and metapodial region, but excluding the mesopodial/basopodial region. - PHENOSCAPE:ni + PHENOSCAPE:ni @@ -284337,13 +285411,13 @@ A subdivision of the autopod skeleton consisting of both acropodial skeleon and metapodial skeleton, but excluding the mesopodial/basopodial skeleton. - PHENOSCAPE:ni + PHENOSCAPE:ni digitopodium - PHENOSCAPE:ni + PHENOSCAPE:ni @@ -284405,7 +285479,7 @@ A subdivision of the manus skeleton consisting of both manual acropodial skeleton and metacarpal skeleton, but excluding the carpal skeleton. - PHENOSCAPE:ni + PHENOSCAPE:ni @@ -284450,7 +285524,7 @@ A subdivision of the pes skeleton consisting of both pedal acropodial skeleton and metatarsal skeleton, but excluding the tarsal skeleton. - PHENOSCAPE:ni + PHENOSCAPE:ni @@ -289100,7 +290174,7 @@ - + @@ -294869,41 +295943,41 @@ isthmus cinguli - NeuroNames:163 + NeuroNames:163 isthmus gyri cingulatus - NeuroNames:163 + NeuroNames:163 isthmus gyri cinguli - NeuroNames:163 + NeuroNames:163 isthmus of gyrus fornicatus - NeuroNames:163 + NeuroNames:163 isthmus of the cingulate gyrus - NeuroNames:163 + NeuroNames:163 isthmus-2 - NeuroNames:163 + NeuroNames:163 @@ -297602,7 +298676,7 @@ The major preaxial endochondral element in the posterior zeugopod[Phenoscape]. - PHENOSCAPE:mah + PHENOSCAPE:mah @@ -299097,7 +300171,7 @@ - + @@ -300527,7 +301601,7 @@ - + @@ -304444,7 +305518,7 @@ A bony structure embedded in skin, roughly equivalent to osteoderms. - PHENOSCAPE:Nizar + PHENOSCAPE:Nizar @@ -307725,39 +308799,39 @@ accessory nucleus of anterior column of spinal cord - NeuroNames:2003 + NeuroNames:2003 nucleus accessorius columnae anterioris medullae spinalis - NeuroNames:2003 + NeuroNames:2003 nucleus nervi accessorii - NeuroNames:2003 + NeuroNames:2003 nucleus of accessory nerve - NeuroNames:2003 + NeuroNames:2003 nucleus of the accessory nerve - NeuroNames:2003 + NeuroNames:2003 nucleus of the spinal accessory nerve - NeuroNames:2003 + NeuroNames:2003 @@ -308162,6 +309236,67 @@ + + + + + + + + + + + + + + + + + Note that in some lamination schemes, more particularly so in primates, this layer is referred to as layer IV thus resulting in some confusion when compared to the present scheme where the lamina dissecans is referred to layer IV[DOI:10.1155/2008/381243] + NLX:144263 + uberon + primary motor cortex lamina V + primary motor cortex layer V + UBERON:0022315 + primary motor cortex layer 5 + + + + + + + + + + + nlx + + + + + + + + + + + nlx + + + + + primary motor cortex lamina V + NLX:144263 + + + + + primary motor cortex layer V + NLX:144263 + + + + @@ -308536,6 +309671,39 @@ + + + + + + + + + + + A set of neural structures that subserve a specific function, e.g., visual system + this class was inherited from NIFSTD as part of the replacement of NIFSTD with Uberon. It may be obsoleted in the future + NLXANAT:090802 + neural system + uberon + UBERON:0023879 + neural system + + + + + A set of neural structures that subserve a specific function, e.g., visual system + NLXANAT:090802 + + + + + neural system + NLXANAT:090802 + + + + @@ -308629,6 +309797,39 @@ + + + + + The part of the central nervous system that is involved with movement. + NLXANAT:090805 + motor system + uberon + UBERON:0025525 + It consists of the pyramidal and extrapyramidal system + motor system + + + + + + NIFSTD + + + + + The part of the central nervous system that is involved with movement. + + + + + + motor system + NLXANAT:090805 + + + + @@ -310278,7 +311479,7 @@ The epithelial layer covering the biliary system. This includes the epithelium of the gallbladder (when present) as well as the intrahepatic and extrahepatic bile ducts. BTO:0001513 - MGI:cs + MGI:cs @@ -314913,7 +316114,7 @@ - + @@ -315022,6 +316223,52 @@ + + + + + + + + + + + The corticobulbar and corticospinal tracts combined. + pyramidal tract + + uberon + UBERON:0036224 + corticobulbar and corticospinal tracts + + + + + + + + + + + NIFSTD + + + + + The corticobulbar and corticospinal tracts combined. + + + + + + pyramidal tract + + BIRNLEX:1464 + MP:0002878 + + + + + @@ -317217,6 +318464,78 @@ + + + + + + + + + + + + + + + + + + + + + + FMA:54242 + neck hair + uberon + UBERON:0037458 + hair of neck + + + + + neck hair + FMA:54242 + + + + + + + + + + + + + + + + + + + + + + + + + + FMA:54243 + limb hair + uberon + UBERON:0037459 + hair of limb + + + + + limb hair + FMA:54243 + + + + @@ -317428,6 +318747,43 @@ + + + + + + + + + + + + + + + + + + + + + + An anatomical junction between two parts of the digestive tract. + + 2021-02-05T11:19:31Z + uberon + UBERON:1100000 + digestive tract junction + + + + + An anatomical junction between two parts of the digestive tract. + ORCID:0000-0002-7073-9172 + + + + @@ -319302,6 +320658,740 @@ + + + + + + + + + + + + Any of the metabolic zones found in the hepatic acinus. Liver tissue is heterogenous at the level of morphometry and histochemistry. This heterogeneity is linked to the position of a cell within the functional unit of the tissue, which, in turn, is related to the blood supply: Cells located in the upstream zone differ from those in the downstream zone with respect to subcellular structures, key enzymes, translocators, and receptors and, therefore, have different metabolic capacities. This is the basis for "metabolic zonation", a concept first proposed for carbohydrate metabolism and later expanded to include amino acid and ammonia metabolism, xenobiotic metabolism, protective metabolism, and formation of plasma proteins. + http://orcid.org/0000-0003-2034-601X + 202z-09-29T15:45:36Z + hepatic acinus metabolic zone + uberon + UBERON:8400005 + metabolic zone of liver + + + + + Any of the metabolic zones found in the hepatic acinus. Liver tissue is heterogenous at the level of morphometry and histochemistry. This heterogeneity is linked to the position of a cell within the functional unit of the tissue, which, in turn, is related to the blood supply: Cells located in the upstream zone differ from those in the downstream zone with respect to subcellular structures, key enzymes, translocators, and receptors and, therefore, have different metabolic capacities. This is the basis for "metabolic zonation", a concept first proposed for carbohydrate metabolism and later expanded to include amino acid and ammonia metabolism, xenobiotic metabolism, protective metabolism, and formation of plasma proteins. + + + + + + hepatic acinus metabolic zone + + + + + + + + + + + + + + + + + + + + + + The region of the liver lobule that is closest to the portal triad. + http://orcid.org/0000-0003-2034-601X + 2020-10-05T12:56:57Z + uberon + hepatic acinus zone 1 + UBERON:8400006 + liver lobule periportal region + + + + + The region of the liver lobule that is closest to the portal triad. + + + + + + hepatic acinus zone 1 + + + + + + + + + + + + + + + + + + + + + + The region of the liver lobule that is closest to the central vein. + http://orcid.org/0000-0003-2034-601X + 2020-10-05T15:43:18Z + uberon + hepatic acinus zone 3 + UBERON:8400007 + liver lobule centrilobular region + + + + + The region of the liver lobule that is closest to the central vein. + + + + + + hepatic acinus zone 3 + + + + + + + + + + + + + + + + + + + + + + + + + + + + The region of the liver lobule that is between the periportal and centrilobular regions. + http://orcid.org/0000-0003-2034-601X + 2020-10-05T15:52:22Z + uberon + hepatic acinus zone 2 + UBERON:8400008 + liver lobule midzonal region + + + + + The region of the liver lobule that is between the periportal and centrilobular regions. + + + + + + hepatic acinus zone 2 + + + + + + + + + + + + + + + + + + + + + + + + + + + + Hepatic serous coat; peritoneal covering of the liver, enclosing almost all except for a triangular area on its posterior surface (the "bare area of the liver") and a smaller area where the liver and gallbladder are in direct contact. + https://orcid.org/0000-0003-2034-601X + serosa of liver + tunica serosa hepatis + uberon + UBERON:8400021 + liver serosa + + + + + Hepatic serous coat; peritoneal covering of the liver, enclosing almost all except for a triangular area on its posterior surface (the "bare area of the liver") and a smaller area where the liver and gallbladder are in direct contact. + + + + + + + serosa of liver + FMA:15811 + + + + + tunica serosa hepatis + LATIN + + + + + + + + + + + + + + + + + + + + + + + + + + + + Subserosal tissue of liver. A zone of areolar connective tissue lying beneath the serous coat of the liver and distinguished with difficulty from the fibrous capsule of Glisson. + https://orcid.org/0000-0003-2034-601X + hepatic subserosa + subserosal tissue of liver + subserous layer of liver + tela subserosa (hepar) + tela subserosa hepatis + uberon + UBERON:8400023 + liver subserosa + + + + + Subserosal tissue of liver. A zone of areolar connective tissue lying beneath the serous coat of the liver and distinguished with difficulty from the fibrous capsule of Glisson. + + + FMA:15812 + + + + + tela subserosa (hepar) + FMA:15821 + + + + + tela subserosa hepatis + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Region of liver parenchyma immediately below the capsule. This region is frequently specified in pathology diagnoses. + https://orcid.org/0000-0003-2034-601X + liver subcapsular region + liver subcapsular tissue + subcapsular tissue of liver + uberon + UBERON:8400024 + subcapsular region of liver + + + + + Region of liver parenchyma immediately below the capsule. This region is frequently specified in pathology diagnoses. + + + + + + + liver subcapsular region + + + + + + liver subcapsular tissue + + + + + + subcapsular tissue of liver + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The anatomical junction between the duodenum and the jejunum. + + FMA:15957 + TA2:2952 + WikipediaVersioned:Duodenojejunal_flexure&oldid=937307798 + duodeno-jejunal flexure + duodenojejunal flexure + duodenojejunal junction + flexura duodenojejunalis + uberon + UBERON:8410000 + duodeno-jejunal junction + + + + + The anatomical junction between the duodenum and the jejunum. + + + + + + + flexura duodenojejunalis + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The anatomical junction between the descending colon and the sigmoid colon. + http://orcid.org/0000-0002-2825-0621 + sigmoid junction + descending-sigmoid colon junction + descending-sigmoid junction + uberon + UBERON:8410016 + descending sigmoid junction + + + + + The anatomical junction between the descending colon and the sigmoid colon. + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A portal vein that drains the descending colon. It is a tributary of the inferior mesenteric vein, and follows the path of its corresponding artery, the left colic artery. + http://orcid.org/0000-0002-2825-0621 + FMA:15394 + uberon + UBERON:8410017 + left colic vein + + + + + A portal vein that drains the descending colon. It is a tributary of the inferior mesenteric vein, and follows the path of its corresponding artery, the left colic artery. + + WikipediaVersioned:Left_colic_vein&oldid=964575339 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A portal vein that drains the ascending colon. It is a tributary of the superior mesenteric vein, and travels with its corresponding artery, the right colic artery. + http://orcid.org/0000-0002-2825-0621 + FMA:15407 + uberon + UBERON:8410018 + right colic vein + + + + + A portal vein that drains the ascending colon. It is a tributary of the superior mesenteric vein, and travels with its corresponding artery, the right colic artery. + + WikipediaVersioned:Right_colic_vein&oldid=870898828 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + The area where the jejunum ends and the ileum part of the intestine begins. Although there is no clear distinct section, the ileum is narrower and has smaller villi than the jejunum. + http://orcid.org/0000-0002-2825-0621 + jejunoileal junction + uberon + UBERON:8410019 + jejuno-ileal junction + + + + + The area where the jejunum ends and the ileum part of the intestine begins. Although there is no clear distinct section, the ileum is narrower and has smaller villi than the jejunum. + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + An anatomical junction between two parts of the intestine. + http://orcid.org/0000-0002-2825-0621 + junction of intestine + uberon + UBERON:8410024 + intestinal junction + + + + + An anatomical junction between two parts of the intestine. + ORCID:0000-0002-7073-9172 + + + + + + + + + + + + + + + + + + + + + + + + + + A vein where lymph node venules condense and which exits at the lymph node hilum. It is also called hilar vein. + http://orcid.org/0000-0002-2825-0621 + hilar vein of lymph node + vein of lymph node + uberon + UBERON:8410033 + lymph node vein + + + + + A vein where lymph node venules condense and which exits at the lymph node hilum. It is also called hilar vein. + + + WikipediaVersioned:Lymph_node&oldid=1001655735#Structure + + + + + + + + + + + + + + + + + + + + + + + + + + An artery that enters the lymph node at the hilum and branches into smaller arterioles. + artery of lymph node + hilar artery of lymph node + uberon + UBERON:8410034 + lymph node artery + + + + + An artery that enters the lymph node at the hilum and branches into smaller arterioles. + + + WikipediaVersioned:Lymph_node&oldid=1001655735#Structure + + + + + + + + A distinct juvenile form many animals undergo before metamorphosis into adults. Animals with indirect development such as insects, amphibians, or cnidarians typically have a larval phase of their life cycle. + A distinct juvenile form many animals undergo before metamorphosis into adults. Animals with indirect development such as insects, amphibians, or cnidarians typically have a larval phase of their life cycle. + 在蜕变成成年人之前，许多动物都经历的一种特定的幼年形态。具有间接发育的动物如昆虫、两栖动物或腔肠动物通常在它们的生命周期中有一个幼虫期。 + TODO discriminate between stages and organisms + TODO discriminate between stages and organisms + 待办事项区分阶段和有机体 + + + Whole organism that is premetamorphic or a very immature individual.[TAO] + Whole organism that is premetamorphic or a very immature individual.[TAO] + 预变性或非常不成熟的个体的整个生物体。 + larval + larval + 幼虫 + + AEO:0000126 + AEO:0000126 + BTO:0000707 + BTO:0000707 + FBbt:00001727 + FBbt:00001727 + HAO:0000459 + HAO:0000459 + OpenCyc:Mx4rwQCBvZwpEbGdrcN5Y29ycA + OpenCyc:Mx4rwQCBvZwpEbGdrcN5Y29ycA + TAO:0002048 + TAO:0002048 + larval organism + larval organism + 幼虫生物体 + ammocoete + ammocoete + bipinnaria + bipinnaria + caterpillar + caterpillar + glochidium + glochidium + grub + grub + leptocephalus + leptocephalus + maggot + maggot + naiad + naiad + nymph + nymph + planula + planula + tadpole + tadpole + trochophore + trochophore + veliger + veliger + wriggler + wriggler + zoea + zoea + 孑孓 + 幼七鳃鳗 + 担轮幼虫 + 毛虫 + 浮浪幼虫 + 瓣钩幼虫 + 稚虫 + 羽腕幼虫 + 蚤状幼体 + 蛆 + 蛴螬 + 蛹 + 蝌蚪 + 面盘幼体 + 鳗的柳叶状幼体 + uberon + uberon + UBERON:0002548 + UBERON:0002548 + + larva + larva + 幼体 + + + + @@ -52748,19 +52839,19 @@ pulmonary arterial and venous trees. Examples: There is only one heart. CALOHA:TS-0579 - EV:0100050 Lymph nodes that are associated with the lymphatic system have evolved in mammals.[well established][VHOG] + EV:0100050 UBERON:0000029 UMLS:C0024204 MA:0000139 + 淋巴结 GAID:947 ZFA_RETIRED:0005318 - 淋巴结 UMLS:C0024204 + ZFA_RETIRED:0005318 - ZFA_RETIRED:0005318 OpenCyc:Mx4rwLPqLpwpEbGdrcN5Y29ycA 结节淋巴瘤 EV:0100050 @@ -52792,8 +52883,8 @@ pulmonary arterial and venous trees. Examples: There is only one heart. MA:0000139 - EMAPA:35523 + 淋巴腺 @@ -52808,11 +52899,11 @@ pulmonary arterial and venous trees. Examples: There is only one heart.MAT:0000442 MESH:D008198 - + CALOHA:TS-0579 - 与淋巴系统有关的淋巴结已经在哺乳动物中进化。[well established][VHOG] TAO_RETIRED:0005318 + 与淋巴系统有关的淋巴结已经在哺乳动物中进化。[well established][VHOG] UBERON:0000029 galen:Lymphnode @@ -52832,8 +52923,8 @@ pulmonary arterial and venous trees. Examples: There is only one heart. mesodermal mantle - 胚胎的中间胚层，在内胚层和外胚层之间。 embryonic mesoderm + 胚胎的中间胚层，在内胚层和外胚层之间。 胚胎中胚层 @@ -52848,13 +52939,13 @@ pulmonary arterial and venous trees. Examples: There is only one heart.由呼吸相关结构组成的功能系统。 apparatus respiratorius + Functional system which consists of structures involved in respiration. - Functional system which consists of structures involved in respiration. systema respiratorium - apparatus respiratorius + respiratory system 呼吸系统(Atmungssystem) @@ -52872,8 +52963,8 @@ pulmonary arterial and venous trees. Examples: There is only one heart.系统呼吸器 呼吸系统(respiratory system) Atmungssystem - systema respiratorium respiratory system + systema respiratorium @@ -52922,15 +53013,15 @@ pulmonary arterial and venous trees. Examples: There is only one heart.neuraxis EFO:0000908 The brain and spinal cord. Kimmel et al, 1995.[TAO] - MESH:D002490 uberon + MESH:D002490 EHDAA2:0000225 BTO:0000227 EMAPA:16754 The central nervous system (CNS) is the part of the nervous system which includes the brain, spinal cord, and nerve cell layer of the retina (CUMBO). - (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...) (reference 1); The neural tube is destined to differentiate into the brain and spinal cord (the central nervous system) (reference 2); Taken together, our data make a very strong case that the complex molecular mediolateral architecture of the developing trunk CNS (central nervous system), as shared between Platynereis and vertebrates, was already present in their last common ancestor, Urbilateria. The concept of bilaterian nervous system centralization implies that neuron types concentrate on one side of the trunk, as is the case in vertebrates and many invertebrates including Platynereis, where they segregate and become spatially organized (as opposed to a diffuse nerve net). Our data reveal that a large part of the spatial organization of the annelid and vertebrate CNS was already present in their last common ancestor, which implies that Urbilateria had already possessed a CNS (reference 3).[well established][VHOG] - XAO:0000215 FBbt:00005094 + XAO:0000215 + (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...) (reference 1); The neural tube is destined to differentiate into the brain and spinal cord (the central nervous system) (reference 2); Taken together, our data make a very strong case that the complex molecular mediolateral architecture of the developing trunk CNS (central nervous system), as shared between Platynereis and vertebrates, was already present in their last common ancestor, Urbilateria. The concept of bilaterian nervous system centralization implies that neuron types concentrate on one side of the trunk, as is the case in vertebrates and many invertebrates including Platynereis, where they segregate and become spatially organized (as opposed to a diffuse nerve net). Our data reveal that a large part of the spatial organization of the annelid and vertebrate CNS was already present in their last common ancestor, which implies that Urbilateria had already possessed a CNS (reference 3).[well established][VHOG] cerebrospinal axis CALOHA:TS-0150 @@ -52959,9 +53050,9 @@ pulmonary arterial and venous trees. Examples: There is only one heart.uberon EMAPA:16470 - 大脑和脊髓。Kimmel et al, 1995.[TAO] TAO:0000012 + 大脑和脊髓。Kimmel et al, 1995.[TAO] The central nervous system (CNS) is the part of the nervous system which includes the brain, spinal cord, and nerve cell layer of the retina (CUMBO). GAID:570 systema nervosum centrale @@ -52987,9 +53078,9 @@ pulmonary arterial and venous trees. Examples: There is only one heart.脑脊髓轴 + 消化道(digestive canal) digestive canal gut tube - 消化道(digestive canal) 肠道 digestive tube alimentary canal @@ -53001,15 +53092,15 @@ pulmonary arterial and venous trees. Examples: There is only one heart.digestive tube alimentary canal 消化道 - 从口腔延伸到肛门的管 digestive tract + 从口腔延伸到肛门的管 消化道(alimentary canal) - gut + gut alimentary tract - gut + gut gut tube digestive tract diff --git a/src/ontology/imports/go_import.owl b/src/ontology/imports/go_import.owl index 0c697e4cd..b62ed269e 100644 --- a/src/ontology/imports/go_import.owl +++ b/src/ontology/imports/go_import.owl @@ -11,9 +11,9 @@ xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"> - + - 2021-06-28 + 2021-06-29 @@ -25452,7 +25452,7 @@ The appearance of type I interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. GOC:add ISBN:0126896631 - PMID:15546383 + PMID:15546383 PMID:16681834 @@ -25487,7 +25487,7 @@ The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon. GOC:add GOC:mah - PMID:15546383 + PMID:15546383 @@ -25909,7 +25909,7 @@ Any process that modulates the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. GOC:add GOC:mah - PMID:15546383 + PMID:15546383 @@ -26495,7 +26495,7 @@ Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. GOC:add GOC:mah - PMID:15546383 + PMID:15546383 @@ -27155,7 +27155,7 @@ Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. GOC:add GOC:mah - PMID:15546383 + PMID:15546383 @@ -31220,6 +31220,35 @@ + + + + + The regulated release of pancreatic polypeptide (PP) from a cell. Pancreatic polypeptide is a 36 amino acid polypeptide secreted by islets of Langerhans cells in the pancreas. + bf + 2012-09-04T14:39:03Z + PP secretion + biological_process + GO:0036322 + pancreatic polypeptide secretion + + + + + The regulated release of pancreatic polypeptide (PP) from a cell. Pancreatic polypeptide is a 36 amino acid polypeptide secreted by islets of Langerhans cells in the pancreas. + GOC:cjm + PMID:12730894 + Wikipedia:Pancreatic_polypeptide + + + + + PP secretion + GOC:cjm + + + + @@ -35349,7 +35378,7 @@ Any process evolved to enable an interaction with an organism of a different species. - GOC:cc + GOC:cc @@ -48545,7 +48574,7 @@ The chemical reactions and pathways resulting in the formation of a nitric-oxide synthase, an enzyme which catalyzes the reaction L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+. - EC:1.14.13.39 + EC:1.14.13.39 GOC:ai diff --git a/src/ontology/imports/go_terms.txt b/src/ontology/imports/go_terms.txt index abd89d5a8..028905b8f 100644 --- a/src/ontology/imports/go_terms.txt +++ b/src/ontology/imports/go_terms.txt @@ -1,2 +1,3 @@ GO:0008150 -GO:0015979 \ No newline at end of file +GO:0015979 +GO:0036322 diff --git a/src/ontology/imports/ncbitaxon_import.owl b/src/ontology/imports/ncbitaxon_import.owl index 57b1b407a..4c2b37590 100644 --- a/src/ontology/imports/ncbitaxon_import.owl +++ b/src/ontology/imports/ncbitaxon_import.owl @@ -9,8 +9,8 @@ xmlns:taxslim="http://purl.obolibrary.org/obo/ncbitaxon/subsets/taxslim#" xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"> - - 2021-06-28 + + 2021-06-29 @@ -384,6 +384,26 @@ + + + + + + GC_ID:1 + ncbi_taxonomy + Archiascomycota + NCBITaxon:147554 + Schizosaccharomycetes + + + + + Archiascomycota + + + + + @@ -869,6 +889,19 @@ + + + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:34346 + Schizosaccharomycetales + + + + @@ -936,6 +969,37 @@ + + + + + + GC_ID:1 + PMID:15689432 + PMID:16151185 + PMID:17010206 + PMID:17051209 + PMID:17572334 + ncbi_taxonomy + NCBITaxon:451864 + Dikarya + + + + + + + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:451866 + Taphrinomycotina + + + + @@ -971,6 +1035,109 @@ + + + + + + GC_ID:1 + PMID:17572334 + ascomycetes + sac fungi + ncbi_taxonomy + ascomycetes + NCBITaxon:4890 + Ascomycota + + + + + ascomycetes + + + + + + sac fungi + + + + + + ascomycetes + + + + + + + + + + + GC_ID:1 + fission yeasts + ncbi_taxonomy + Schizosaccharomycetoideae + NCBITaxon:4894 + Schizosaccharomycetaceae + + + + + fission yeasts + + + + + + Schizosaccharomycetoideae + + + + + + + + + + + GC_ID:1 + ncbi_taxonomy + NCBITaxon:4895 + Schizosaccharomyces + + + + + + + + + + NCBITaxon:45042 + GC_ID:1 + fission yeast + ncbi_taxonomy + Schizosaccharomyces malidevorans + NCBITaxon:4896 + Schizosaccharomyces pombe + + + + + fission yeast + + + + + + Schizosaccharomyces malidevorans + + + + + diff --git a/src/ontology/imports/ncbitaxon_terms.txt b/src/ontology/imports/ncbitaxon_terms.txt index 1bbea25ef..f76ca8c3f 100644 --- a/src/ontology/imports/ncbitaxon_terms.txt +++ b/src/ontology/imports/ncbitaxon_terms.txt @@ -3,3 +3,4 @@ NCBITaxon:142796 ## Mycetozoa NCBITaxon:9443 ## Primate NCBITaxon:9685 ## Cat NCBITaxon:6237 ## Caenorhabditis +NCBITaxon:4896 ## Schizosaccharomyces pombe diff --git a/src/ontology/imports/pato_import.owl b/src/ontology/imports/pato_import.owl index 7eb5e8153..77353422c 100644 --- a/src/ontology/imports/pato_import.owl +++ b/src/ontology/imports/pato_import.owl @@ -21,9 +21,9 @@ xmlns:subsets="http://purl.obolibrary.org/obo/ro/subsets#" xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"> - + - 2021-06-28 + 2021-06-29 @@ -4743,9 +4743,9 @@ For example, A and B may be gene products and binding of B by A positively regul A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. - GOC:cilia + GOC:cilia GOC:curators - GOC:kmv + GOC:kmv GOC:vw ISBN:0198547684 PMID:16824949 @@ -4956,8 +4956,8 @@ For example, A and B may be gene products and binding of B by A positively regul A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules. - GOC:cilia - GOC:kmv + GOC:cilia + GOC:kmv PMID:14570576 PMID:22118932 PMID:23945166 @@ -5391,7 +5391,7 @@ For example, A and B may be gene products and binding of B by A positively regul All of the contents of a cilium, excluding the plasma membrane surrounding the cilium. GOC:BHF - GOC:cilia + GOC:cilia GOC:dos PMID:17895364 @@ -5596,7 +5596,7 @@ For example, A and B may be gene products and binding of B by A positively regul A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex. - GOC:kmv + GOC:kmv @@ -8019,7 +8019,7 @@ For example, A and B may be gene products and binding of B by A positively regul A neuron projection quality that is a characteristic of neurons whose soma is located in the telencephalon and that project to structures outside the telencephalon - DOI:10.1101/2020.10.19.343129 + DOI:10.1101/2020.10.19.343129 @@ -8040,7 +8040,7 @@ For example, A and B may be gene products and binding of B by A positively regul A neuron projection quality that is a characteristic of neurons with soma in the cerebral cortex and projections to the thalamus. - DOI:10.1101/2020.10.19.343129 + DOI:10.1101/2020.10.19.343129 @@ -8061,7 +8061,7 @@ For example, A and B may be gene products and binding of B by A positively regul A neuron projection quality that is a characteristic of neurons with projections that terminate locally rather than distantly. - DOI:10.1101/2020.10.19.343129 + DOI:10.1101/2020.10.19.343129 @@ -8081,7 +8081,7 @@ For example, A and B may be gene products and binding of B by A positively regul A neuron projection quality that is a characteristic of neurons that project to the medulla oblongata from other brain regions. - DOI:10.1101/2020.10.19.343129 + DOI:10.1101/2020.10.19.343129 @@ -8100,7 +8100,7 @@ For example, A and B may be gene products and binding of B by A positively regul A physical quality inhering in a neuron by virtue of the relative location of its soma and the regions to which it projects and makes synaptic contacts in. - DOI:10.1101/2020.10.19.343129 + DOI:10.1101/2020.10.19.343129 @@ -8121,7 +8121,7 @@ For example, A and B may be gene products and binding of B by A positively regul A neuron projection quality that is a characteristic of neurons with both soma and projections entirely within the telencephalon. - DOI:10.1101/2020.10.19.343129 + DOI:10.1101/2020.10.19.343129 @@ -18283,7 +18283,7 @@ For example, A and B may be gene products and binding of B by A positively regul A major subdivision of an organism that is the entire part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane. In vertebrares this includes the vertebral column.. BSPO:0000063 - UBERONREF:0000006 + UBERONREF:0000006 @@ -20043,7 +20043,7 @@ For example, A and B may be gene products and binding of B by A positively regul VHOG:0000453 VHOG - DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) + DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) @@ -21912,7 +21912,7 @@ For example, A and B may be gene products and binding of B by A positively regul - BTO + BTO FMA-implicit VHOG ZFA @@ -22355,7 +22355,7 @@ For example, A and B may be gene products and binding of B by A positively regul FB BIRNLEX:1509 - NIFSTD:NeuroNames_abbrevSource + NIFSTD:NeuroNames_abbrevSource @@ -22526,7 +22526,7 @@ For example, A and B may be gene products and binding of B by A positively regul MB BIRNLEX:1667 - NIFSTD:NeuroNames_abbrevSource + NIFSTD:NeuroNames_abbrevSource @@ -23059,7 +23059,7 @@ For example, A and B may be gene products and binding of B by A positively regul DiE BIRNLEX:1503 - NIFSTD:NeuroNames_abbrevSource + NIFSTD:NeuroNames_abbrevSource @@ -23695,7 +23695,7 @@ For example, A and B may be gene products and binding of B by A positively regul MTg BIRNLEX:1200 - NIFSTD:NeuroNames_abbrevSource + NIFSTD:NeuroNames_abbrevSource @@ -26187,7 +26187,7 @@ For example, A and B may be gene products and binding of B by A positively regul Organism subdivision which is the part of the body posterior to the cervical region (or head, when cervical region not present) and anterior to the caudal region. Includes the sacrum when present. TAO:0001115 - UBERONREF:0000006 + UBERONREF:0000006 @@ -28833,7 +28833,7 @@ For example, A and B may be gene products and binding of B by A positively regul - BTO + BTO @@ -28988,7 +28988,7 @@ For example, A and B may be gene products and binding of B by A positively regul VHOG:0000150 VHOG - DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) + DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) @@ -33748,7 +33748,7 @@ For example, A and B may be gene products and binding of B by A positively regul VHOG:0000063 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 @@ -34547,7 +34547,7 @@ For example, A and B may be gene products and binding of B by A positively regul - BTO + BTO @@ -39214,7 +39214,7 @@ For example, A and B may be gene products and binding of B by A positively regul VHOG:0000796 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 @@ -39290,7 +39290,7 @@ For example, A and B may be gene products and binding of B by A positively regul VHOG:0000799 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 @@ -39353,7 +39353,7 @@ For example, A and B may be gene products and binding of B by A positively regul VHOG:0000798 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 @@ -39450,7 +39450,7 @@ For example, A and B may be gene products and binding of B by A positively regul VHOG:0001210 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 @@ -39520,7 +39520,7 @@ For example, A and B may be gene products and binding of B by A positively regul VHOG:0001006 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 @@ -52742,7 +52742,7 @@ For example, A and B may be gene products and binding of B by A positively regul VHOG:0000510 VHOG - DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) + DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) @@ -54007,7 +54007,7 @@ For example, A and B may be gene products and binding of B by A positively regul - BTO + BTO @@ -58997,7 +58997,7 @@ For example, A and B may be gene products and binding of B by A positively regul The part of the trunk that is in the dorsum[cjm]. - UBERONREF:0000006 + UBERONREF:0000006 diff --git a/src/ontology/imports/pr_import.owl b/src/ontology/imports/pr_import.owl index ac46884fd..4d275e41f 100644 --- a/src/ontology/imports/pr_import.owl +++ b/src/ontology/imports/pr_import.owl @@ -9,8 +9,8 @@ xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"> - - 2021-06-28 + + 2021-06-29 @@ -1054,6 +1054,32 @@ + + + + + fission yeast + ncbi_taxonomy + Spom- + NCBITaxon:4896 + Schizosaccharomyces pombe + + + + + fission yeast + PRO:DAN + + + + + Spom- + PRO:DAN + + + + + @@ -1951,6 +1977,21 @@ Category=gene. Requested by=CL. T-cell surface glycoprotein CD8 alpha chain + + + + A protein that is a translation product of the human CD8A gene or a 1:1 ortholog thereof. CD8 is a transmembrane that is a co-receptor for MHC class-I antigen/T-cell receptor interaction. The most common form of CD8 is composed of a CD8 alpha and a CD8 beta chain. + PMID:11114424 + PRO:CNA + Wikipedia:CD8 + + + + + CD8A + PRO:DNx + + @@ -1969,21 +2010,6 @@ MAL - - - - A protein that is a translation product of the human CD8A gene or a 1:1 ortholog thereof. CD8 is a transmembrane that is a co-receptor for MHC class-I antigen/T-cell receptor interaction. The most common form of CD8 is composed of a CD8 alpha and a CD8 beta chain. - PMID:11114424 - PRO:CNA - Wikipedia:CD8 - - - - - CD8A - PRO:DNx - - @@ -15369,37 +15395,37 @@ A lymphocyte antigen 75 that is encoded in the genome of human. PRO:DAN - UniProtKB:O60449 + UniProtKB:O60449 C-type lectin domain family 13 member B (human) - UniProtKB:O60449 + UniProtKB:O60449 CD205 (human) - UniProtKB:O60449 + UniProtKB:O60449 CLEC13B (human) - UniProtKB:O60449 + UniProtKB:O60449 DEC-205 (human) - UniProtKB:O60449 + UniProtKB:O60449 gp200-MR6 (human) - UniProtKB:O60449 + UniProtKB:O60449 @@ -15412,7 +15438,7 @@ ly-75 (human) - UniProtKB:O60449 + UniProtKB:O60449 diff --git a/src/ontology/imports/ro_import.owl b/src/ontology/imports/ro_import.owl index 45ede8c15..8a786db37 100644 --- a/src/ontology/imports/ro_import.owl +++ b/src/ontology/imports/ro_import.owl @@ -17,9 +17,9 @@ xmlns:subsets="http://purl.obolibrary.org/obo/ro/subsets#" xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"> - + - 2021-06-28 + 2021-06-29 diff --git a/src/ontology/imports/uberon_import.owl b/src/ontology/imports/uberon_import.owl index 31dfdaaf0..069a14c44 100644 --- a/src/ontology/imports/uberon_import.owl +++ b/src/ontology/imports/uberon_import.owl @@ -14,7 +14,7 @@ xmlns:terms="http://purl.org/dc/terms/" xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"> - + @@ -72,7 +72,7 @@ https://docs.google.com/document/d/1cPWBqrl_Qy7XHEWFqtR_PgQX61yRkgGuLaiDpnEXxkE/edit https://docs.google.com/document/d/1r9kNPpFYGdu0SpJDLyFAVQczBlG0wAZCBMd18gG3Ot8/edit# https://docs.google.com/spreadsheet/ccc?key=0Aj8NJdyb-leqdDM0R3hTVTRHRExDVjRCSkZEbDc5N1E#gid=0 - 2021-06-28 + 2021-06-29 @@ -4588,7 +4588,7 @@ A light sensing organ composed of ommatidia - FB:gg + FB:gg @@ -7474,6 +7474,311 @@ + + + + + + + + + + + + + + + + + A distinct juvenile stage many animals undergo before metamorphosis into adults. Animals with indirect development such as insects, amphibians, or cnidarians typically have a larval phase of their life cycle. + Uberon includes clade-specific subclasses, e.g. nematod larva + It is a misunderstanding that the larval form always reflects the group's evolutionary history. It could be the case, but often the larval stage has evolved secondarily, as in insects. In these cases the larval form might differ more from the group's common origin than the adult form + + BTO:0000915 + BTO:0000954 + EFO:0001303 + FBdv:00005336 + MIAA:0000400 + OGES:000008 + ZFS:0000048 + larva stage + ammocoete + ammocoete stage + bipinnaria + bipinnaria stage + caterpillar + caterpillar stage + glochidium + glochidium stage + grub + grub stage + leptocephalus + leptocephalus stage + maggot + maggot stage + metacestode + naiad, nymph + naiad, nymph stage + nauplius + nauplius stage + nymph + nymph stage + planula + planula stage + tornaria + trochophore + trochophore stage + veliger + veliger stage + wriggler + wriggler stage + zoea + zoea stage + uberon + larva + UBERON:0000069 + + larval stage + + + + + A distinct juvenile stage many animals undergo before metamorphosis into adults. Animals with indirect development such as insects, amphibians, or cnidarians typically have a larval phase of their life cycle. + + + + + + It is a misunderstanding that the larval form always reflects the group's evolutionary history. It could be the case, but often the larval stage has evolved secondarily, as in insects. In these cases the larval form might differ more from the group's common origin than the adult form + WP + + + + + ammocoete + + + + + + + ammocoete stage + + + + + + + bipinnaria + + + + + + + bipinnaria stage + + + + + + + caterpillar + + + + + + + caterpillar stage + + + + + + + glochidium + + + + + + + glochidium stage + + + + + + + grub + + + + + + + grub stage + + + + + + + leptocephalus + + + + + + + leptocephalus stage + + + + + + + maggot + + + + + + + maggot stage + + + + + + + metacestode + BTO:0000859 + + + + + + naiad, nymph + + + + + + + naiad, nymph stage + + + + + + + nauplius + + + + + + + nauplius stage + + + + + + + nymph + + + + + + + nymph stage + + + + + + + planula + + + + + + + planula stage + + + + + + + tornaria + NCBITaxon:10219 + + + + + + trochophore + + + + + + + trochophore stage + + + + + + + veliger + + + + + + + veliger stage + + + + + + + wriggler + + + + + + + wriggler stage + + + + + + + zoea + + + + + + + zoea stage + + + + + + @@ -8367,7 +8672,7 @@ - ISBN:9780878932504 + ISBN:9780878932504 @@ -8587,7 +8892,7 @@ - ISBN:9780878932504 + ISBN:9780878932504 @@ -10173,7 +10478,7 @@ in GO lung development is part of respiratory tube development. This can lead to inconsistencies with other ontologies, e.g. VT. The GO structure may be better represented by a tree of tubes (see the FMA class) - GO + GO @@ -11039,12 +11344,6 @@ intestine - - - - - cjm - @@ -11076,6 +11375,12 @@ UMLS:C0021853 ncithesaurus:Intestine + + + + + cjm + @@ -11380,6 +11685,24 @@ primitive urogenital sinus http://upload.wikimedia.org/wikipedia/commons/6/6d/Gray1109.png + + + + + + + + + + MP-def + + + + + the ventral part of the cloaca remaining after septation of the rectum, which further develops into part of the bladder, part of the prostatic part of the male urethra and the urethra and vestibule in females + ISBN:0-683-40008-8 + MP:0010116 + @@ -11436,24 +11759,6 @@ sinus urogenitalis - - - - - - - - - - MP-def - - - - - the ventral part of the cloaca remaining after septation of the rectum, which further develops into part of the bladder, part of the prostatic part of the male urethra and the urethra and vestibule in females - ISBN:0-683-40008-8 - MP:0010116 - @@ -15835,7 +16140,7 @@ VHOG:0000349 VHOG - ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 + ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 @@ -22056,7 +22361,7 @@ Cranial nerve fiber tract which is comprised of retinal ganglion cell axons running posterior medially towards the optic chiasm, at which some of the axons cross the midline and after which the structure is termed the optic tract. Transmits visual information from the retina to the brain[ZFA]. - ISBN:0471209627 + ISBN:0471209627 ISBN:0471888893 @@ -22411,7 +22716,7 @@ VHOG:0001523 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 @@ -23360,7 +23665,7 @@ A decussation of the diencephalon where the fibers of the optic nerve cross - MGI:llw2 + MGI:llw2 MP:0009770 @@ -23370,7 +23675,7 @@ 2012-06-20 AAO:0010622 AAO - AAO:DSM + AAO:DSM @@ -24531,7 +24836,7 @@ Paired endochondral long bone that extends between the pectoral girdle and the skeletal parts of the forelimb. [PHENOSCAPE:mah] AAO:0000679 - PHENOSCAPE:mah + PHENOSCAPE:mah @@ -24550,7 +24855,7 @@ VHOG:0001158 VHOG - ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 + ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 @@ -24787,7 +25092,7 @@ VHOG:0000345 VHOG - ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 + ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 @@ -24865,7 +25170,7 @@ The major preaxial endochondral bone in the posterior zeugopod[Phenoscape]. - PHENOSCAPE:mah + PHENOSCAPE:mah @@ -24999,7 +25304,7 @@ 2012-08-14 VSAO:0000186 VSAO - VSAO:NI + VSAO:NI @@ -25018,7 +25323,7 @@ VHOG:0001159 VHOG - ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 + ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 @@ -27475,7 +27780,7 @@ Anatomical system that has as its parts the organs devoted to the ingestion, digestion, and assimilation of food and the discharge of residual wastes. - FB:gg + FB:gg NLM:alimentary+system @@ -31089,10 +31394,10 @@ The vertebral centrum may be cartilaginous, develop as cartilage but be replaced by bone or mineralized, or form directly through intramembranous ossification.[VSAO] - 2012-09-06 + 2012-09-06 VSAO:0000183 VSAO - Curator + Curator @@ -31237,7 +31542,7 @@ 2012-06-20 AAO:0000705 AAO - AAO:Pugener_and_Maglia_2008 + AAO:Pugener_and_Maglia_2008 @@ -34342,7 +34647,7 @@ A major subdivision of an organism that is the entire part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane. In vertebrares this includes the vertebral column.. BSPO:0000063 - UBERONREF:0000006 + UBERONREF:0000006 @@ -42184,7 +42489,7 @@ the thick outer layer of the adrenal gland that produces and secretes steroid hormones such as corticosterone, estrone and aldosterone ISBN:0-683-40008-8 - MGI:llw2 + MGI:llw2 MP:0008288 @@ -42307,7 +42612,7 @@ the inner portion of the adrenal gland that consists mainly of chromaffin cells which produce, store and secrete neurotransmitters such as epinephrine and norepinephrine MESH:A06.407.071.265 - MGI:llw2 + MGI:llw2 MP:0008289 @@ -51046,10 +51351,10 @@ Note that this class describes the central subdivision of the pectoral girdle complex, NOT the skeleton within.[VSAO] - 2012-09-06 + 2012-09-06 VSAO:0000305 VSAO - Curator + Curator @@ -51338,7 +51643,7 @@ GO defines skeletal system very generically: The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton) GO:0001501; however, all annotations are to vertebrates - GO + GO @@ -51929,7 +52234,7 @@ VHOG:0001256 VHOG - ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 + ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 @@ -52090,7 +52395,7 @@ VHOG:0001255 VHOG - ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 + ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 @@ -52334,7 +52639,7 @@ - FMA-modified + FMA-modified @@ -53351,7 +53656,7 @@ VHOG:0000339 VHOG - ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 + ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 @@ -53505,7 +53810,7 @@ - FMA-modified + FMA-modified @@ -53819,7 +54124,7 @@ - FMA-modified + FMA-modified @@ -58968,7 +59273,7 @@ A muscle that attaches to the hyopid bone and to the tongue and is innervated by cranial nerve XII - FEED:rd + FEED:rd @@ -59202,7 +59507,7 @@ - FEED + FEED Wikipedia @@ -59227,7 +59532,7 @@ The intrinsic tongue muscles are an integral part of the tongue that are innervated by Cranial Nerve XII.[FEED] 2012-07-02 - FEED + FEED http://www.feedexp.org @@ -59320,14 +59625,14 @@ - FEED + FEED Wikipedia A muscle innervated by a facial nerve. - FEED:rd + FEED:rd @@ -59543,7 +59848,7 @@ Nerve that carries information from the olfactory epithelium to the olfactory bulb[Butler and Hodos]. - ISBN:0471209627 + ISBN:0471209627 @@ -59552,7 +59857,7 @@ 2012-06-20 AAO:0010088 AAO - AAO:DSM + AAO:DSM @@ -59574,7 +59879,7 @@ VHOG:0000703 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 @@ -62081,7 +62386,7 @@ Cranial nerve that has three branches - the ophthalmic (supplying the skin of the nose and upper jaw), the maxillary and the mandibular (supplying the lower jaw). - ISBN:0471209627 + ISBN:0471209627 @@ -62100,7 +62405,7 @@ VHOG:0000704 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 @@ -62319,7 +62624,7 @@ Cranial nerve that branches into the supraorbital (supplying the skin of the eye region and the lateral line organs here), the palatine (to the roof of the buccal cavity), and the hyomandibular (dividing into the jugular and mental branches). - ISBN:0471209627 + ISBN:0471209627 @@ -62328,7 +62633,7 @@ 2012-06-20 AAO:0010472 AAO - AAO:DSM + AAO:DSM @@ -62338,7 +62643,7 @@ VHOG:0000706 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 @@ -62545,7 +62850,7 @@ Cranial nerve that transmits sound and equilibrium (balance) information from the inner ear to the brain. - ISBN:0471209627 + ISBN:0471209627 @@ -62554,7 +62859,7 @@ 2012-06-20 AAO:0010473 AAO - AAO:DSM + AAO:DSM @@ -62564,7 +62869,7 @@ VHOG:0000695 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 @@ -62737,7 +63042,7 @@ Cranial nerve that branches into the ramus communicans (to the skin), the pretrematic (to the walls of the pharynx and mouth, viscero-sensory fibers), and the larval post-trematic branch (lost in the adult). - ISBN:0471209627 + ISBN:0471209627 @@ -62756,7 +63061,7 @@ VHOG:0000701 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 @@ -64729,7 +65034,7 @@ in XAO this includes and is only the tympanum - XAO + XAO @@ -66262,7 +66567,7 @@ A muscular organ in the floor of the mouth. - FEED:rd + FEED:rd @@ -66400,7 +66705,7 @@ - FMA-modified + FMA-modified @@ -68505,7 +68810,7 @@ Cranial nerve that branches into the lateral (to body sense organs) and the intestino-accessorial (to the skin, muscles of shoulder, hyoid, larynx, gut, lungs, and heart). - ISBN:0471209627 + ISBN:0471209627 @@ -68524,7 +68829,7 @@ VHOG:0000737 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43, ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.625 @@ -70849,7 +71154,7 @@ VHOG:0000279 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 @@ -72068,7 +72373,7 @@ FMA def states A and P located_in in EHDAA2 - VHOG + VHOG @@ -72082,7 +72387,7 @@ The fluid produced by the ciliary process in the eye and occupying the anterior and posterior chambers. It provides nourishment for the lens and cornea and maintains the ocular pressure, and hence the optical integrity of the eyeball. [TFD][VHOG] 2012-09-17 VHOG:0000548 - VHOG + VHOG @@ -72092,7 +72397,7 @@ (...) we reach the inescapable conclusion that the last common ancestor of jawless and jawed vertebrates already possessed an eye that was comparable to that of extant lampreys and gnathostomes. Accordingly, a vertebrate camera-like eye must have been present by the time that lampreys and gnathostomes diverged, around 500 Mya (reference 1); Although the eye varies greatly in adaptative details among vertebrates, its basic structure is the same in all. The human eye is representative of the design typical for a tetrapod. (...) A watery aqueous humor fills the spaces in the eye in front of the lens (...) (reference 2).[well established][VHOG] 2012-09-17 VHOG:0000548 - VHOG + VHOG DOI:10.1038/nrn2283 Lamb TD, Collin SP and Pugh EN Jr, Evolution of the vertebrate eye: opsins, photoreceptors, retina and eye cup. Nature Reviews Neuroscience (2007), ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.424 and p.426 and p.429 and Figure 12-24 @@ -74696,7 +75001,7 @@ BTO FMA-implicit - VHOG + VHOG ZFA @@ -75313,7 +75618,7 @@ FMA - VHOG + VHOG XAO ncit @@ -75331,7 +75636,7 @@ A spiral-shaped cavity in the petrous portion of the temporal bone of the inner ear, containing the nerve endings essential for hearing and forming one of the divisions of the labyrinth. [TFD][VHOG] 2012-09-17 VHOG:0000691 - VHOG + VHOG @@ -75341,7 +75646,7 @@ Because achieving high sensitivity is generally advantageous for auditory organs, it is not surprising that evidence for cochlear amplification is also seen in nonmammals. Spontaneous otoacoustic emissions (SOAEs) are narrow-band sound signals emitted from the inner ear, and it is generally assumed that their energy derives from the hair-cell molecular motors underlying cochlear amplification. However, all terrestrial vertebrates studied so far (including amphibians) show very similar SOAEs. The most parsimonious explanation for the universality of this phenomena is that some kind of amplifying mechanism is at least as old as land vertebrates themselves.[well established][VHOG] 2012-09-17 VHOG:0000691 - VHOG + VHOG DOI:10.1016/S0959-4388(98)80033-0 Manley GA, Koeppl C, Phylogenetic development of the cochlea and its innervation. Current Opinion in Neurobiology (1998) @@ -77641,7 +77946,7 @@ VHOG:0000069 VHOG - DOI:10.1016/S0959-4388(99)00003-3 Holland LZ and Holland ND, Chordate origins of the vertebrate central nervous system. Current Opinion in Neurobiology (1999) + DOI:10.1016/S0959-4388(99)00003-3 Holland LZ and Holland ND, Chordate origins of the vertebrate central nervous system. Current Opinion in Neurobiology (1999) @@ -78174,7 +78479,7 @@ VHOG:0000318 VHOG - DOI:10.1016/S0959-4388(99)00003-3 Holland LZ and Holland ND, Chordate origins of the vertebrate central nervous system. Current Opinion in Neurobiology (1999) + DOI:10.1016/S0959-4388(99)00003-3 Holland LZ and Holland ND, Chordate origins of the vertebrate central nervous system. Current Opinion in Neurobiology (1999) @@ -84447,7 +84752,7 @@ 2012-06-20 AAO:0010158 AAO - AAO:DSM + AAO:DSM @@ -85143,7 +85448,7 @@ VHOG:0000982 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 @@ -85386,7 +85691,7 @@ VHOG:0001133 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 @@ -85738,7 +86043,7 @@ http://code.google.com/p/xenopus-anatomy-ontology/issues/detail?id=7 - VHOG + VHOG Wikipedia @@ -85754,7 +86059,7 @@ Cranial nerve that innervates the sternocleidomastoid and trapezius complex of muscles. [Bemis_WE, Functional_Anatomy_of_the_Vertebrates:_An_Evolutionary_Perspective, Glossary_G-1, Grande_L, Liem_KF, Third_Edition_(2001)_Orlando_Fla.:_Harcourt_College_Publishers, Walker_WF][VHOG] 2012-09-17 VHOG:0000699 - VHOG + VHOG @@ -85772,7 +86077,7 @@ Cranial nerves XI and XII evolved in the common ancestor to amniotes (non-amphibian tetrapods) thus totalling twelve pairs.[well established][VHOG] 2012-09-17 VHOG:0000699 - VHOG + VHOG @@ -86414,7 +86719,7 @@ VHOG:0000070 VHOG - DOI:10.1016/S0959-4388(99)00003-3 Holland LZ and Holland ND, Chordate origins of the vertebrate central nervous system. Current Opinion in Neurobiology (1999) + DOI:10.1016/S0959-4388(99)00003-3 Holland LZ and Holland ND, Chordate origins of the vertebrate central nervous system. Current Opinion in Neurobiology (1999) @@ -88309,7 +88614,7 @@ the narrow subcapsular outer zone of the adrenal cortex where aldosterone is produced MESH:A06.407.071.140.960 - MGI:llw2 + MGI:llw2 MP:0008293 @@ -88782,7 +89087,7 @@ - VHOG + VHOG @@ -88826,7 +89131,7 @@ In the primitive vertebrate heart the four chambers are: 1. Sinus venosus (...) 2. Atrium (...) 3. Ventricle (...) 4. Conus arteriosus (...).[well established][VHOG] 2012-09-17 VHOG:0000177 - VHOG + VHOG ISBN:978-0721676678 Romer AS, Vertebrate body (1970) p.428 @@ -89259,7 +89564,7 @@ - FMA-modified + FMA-modified @@ -89671,7 +89976,7 @@ smooth and glossy outer protective cell layer of hair shaft - MGI:llw2 + MGI:llw2 MP:0003810 @@ -89818,7 +90123,7 @@ VHOG:0000328 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 @@ -89925,7 +90230,7 @@ VHOG:0000369 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 @@ -90526,7 +90831,7 @@ VHOG:0000385 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 @@ -90972,6 +91277,24 @@ spinal dura mater + + + + UMLS:C0228124 + ncithesaurus:Spinal_Cord_Dura_Mater + + + + + dura mater of neuraxis of spinal cord + OBOL:automatic + + + + + spinal cord dura mater of neuraxis + OBOL:automatic + @@ -90997,24 +91320,6 @@ ISBN:978-0072528305 Kardong KV, Vertebrates: Comparative Anatomy, Function, Evolution (2006) p.639 - - - - UMLS:C0228124 - ncithesaurus:Spinal_Cord_Dura_Mater - - - - - dura mater of neuraxis of spinal cord - OBOL:automatic - - - - - spinal cord dura mater of neuraxis - OBOL:automatic - @@ -91317,6 +91622,17 @@ skin of body http://upload.wikimedia.org/wikipedia/commons/6/6d/Skin.svg + + + + + + + + + + Wikipathways:WP2062 + @@ -91335,17 +91651,6 @@ UMLS:C1123023 ncithesaurus:Skin - - - - - - - - - - Wikipathways:WP2062 - @@ -91417,7 +91722,7 @@ in GO, septum morphogenesis is part of cardiac chamber morphogenesis; need to add axioms to infer this - GO + GO @@ -91500,7 +91805,7 @@ Organism subdivision which is the part of the body posterior to the cervical region (or head, when cervical region not present) and anterior to the caudal region. Includes the sacrum when present. TAO:0001115 - UBERONREF:0000006 + UBERONREF:0000006 @@ -91643,7 +91948,7 @@ VHOG:0000336 VHOG - ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 + ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 @@ -91932,7 +92237,7 @@ VHOG:0000337 VHOG - ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 + ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 @@ -93265,7 +93570,7 @@ The first part of the small intestine. At the junction of the stomach and the duodenum the alimentary canal is inflected. The duodenum first goes anteriorly for a short distance, turns dorsally, and eventually caudally, thus it is a U-shaped structure with two horizontal sections (a ventral and a dorsal one). - ISBN:0815318960 + ISBN:0815318960 @@ -96080,7 +96385,7 @@ VHOG:0000141 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.510 and Figure 15-5 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.510 and Figure 15-5 @@ -96325,7 +96630,7 @@ VHOG:0000142 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.510 and Figure 15-5 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.510 and Figure 15-5 @@ -98779,7 +99084,7 @@ the jelly-like substance in the middle of the spinal disc which is a remnant of the notochord - MGI:llw2 + MGI:llw2 MP:0006392 @@ -98897,7 +99202,7 @@ - EHDAA2-abduced + EHDAA2-abduced @@ -99827,7 +100132,7 @@ The definition was adapted from the NIFSTD class which has been retired. It has been generalized so it is applicable to various different kinds of olfactory tracts found in different taxa. - cjm + cjm ISBN:0471888893 @@ -101806,13 +102111,13 @@ fimbria (Vieussens) - NeuroNames:187 + NeuroNames:187 fimbria fornicis - NeuroNames:187 + NeuroNames:187 @@ -101826,20 +102131,20 @@ fimbria hippocampi - NeuroNames:187 + NeuroNames:187 fimbria of fornix - NeuroNames:187 + NeuroNames:187 fimbria of the hippocampus - NeuroNames:187 + NeuroNames:187 @@ -103039,7 +103344,7 @@ - ISBN:0815318960 + ISBN:0815318960 @@ -106306,7 +106611,7 @@ AAO:0010551 - BTO:0000047 + BTO:0000047 CALOHA:TS-0016 EFO:0000238 EMAPA:18426 @@ -106320,7 +106625,7 @@ NCIT:C12666 OpenCyc:Mx4rvXYiz5wpEbGdrcN5Y29ycA UMLS:C0001625 - VHOG:0001141 + VHOG:0001141 XAO:0000164 galen:AdrenalGland glandula adrenalis @@ -106371,7 +106676,7 @@ Either of a pair of complex endocrine organs near the anterior medial border of the kidney consisting of a mesodermal cortex that produces glucocorticoid, mineralocorticoid, and androgenic hormones and an ectodermal medulla that produces epinephrine and norepinephrine[BTO]. - BTO:0000047 + BTO:0000047 @@ -106387,7 +106692,7 @@ All craniates have groups of cells homologous to the mammalian adrenocortical and chromaffin tissues, but they are scattered in and near the kidneys in fishes. (...) The cortical and chromaffin tissues come together to form adrenal glands in tetrapods.[well established][VHOG] 2012-09-17 - VHOG:0001141 + VHOG:0001141 VHOG ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.518 and Figure 15-9 @@ -106416,19 +106721,19 @@ adrenal - BTO:0000047 + BTO:0000047 adrenal capsule - BTO:0000047 + BTO:0000047 atrabiliary capsule - BTO:0000047 + BTO:0000047 @@ -106440,13 +106745,13 @@ epinephros - BTO:0000047 + BTO:0000047 glandula suprarenalis - BTO:0000047 + BTO:0000047 @@ -106459,7 +106764,7 @@ suprarenal capsule - BTO:0000047 + BTO:0000047 @@ -107004,7 +107309,7 @@ - EHDAA2-abduced + EHDAA2-abduced @@ -107846,7 +108151,7 @@ The middle limb segment of the pectoral free limb, between the autopod and stylopod segments. Includes as parts the forelimb zeugopodial skeleton, which includes as parts the radius and ulna, or their cartilage precursors, or evolutionary variants. - PHENOSCAPE:curators + PHENOSCAPE:curators @@ -107865,7 +108170,7 @@ VHOG:0000341 VHOG - ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 + ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 @@ -110035,7 +110340,7 @@ 2012-06-20 AAO:0000691 AAO - AAO:Pugener_and_Maglia_2008 + AAO:Pugener_and_Maglia_2008 @@ -113332,7 +113637,7 @@ The middle free limb segment, between the autopod and stylopod segments. Includes as parts the zeugopodial skeleton. Examples: There are two types of zeugopod: forelimb zeugopod (aka forearm), hindlimb zeugopod (aka crus). - PHENOSCAPE:curators + PHENOSCAPE:curators @@ -114951,7 +115256,7 @@ the crystalline particles composed of calcium carbonate and a protein which adhere to the gelatinous membrane of the maculae of the utricle and saccule (otolithic membrane) ISBN:0-683-40008-8 - MGI:llw2 + MGI:llw2 MP:0002894 @@ -115885,8 +116190,8 @@ A line of sensory organs and associated structures along the sides of fish and amphibia that detect vibrations and pressure changes. - ISBN:0471209627 - ISBN:0815318960 + ISBN:0471209627 + ISBN:0815318960 @@ -116132,6 +116437,173 @@ + + + + + + + + + + + + + + + + + + + + + + A distinct juvenile form many animals undergo before metamorphosis into adults. Animals with indirect development such as insects, amphibians, or cnidarians typically have a larval phase of their life cycle. + TODO discriminate between stages and organisms + Whole organism that is premetamorphic or a very immature individual.[TAO] + larval + + AEO:0000126 + BTO:0000707 + FBbt:00001727 + HAO:0000459 + OpenCyc:Mx4rwQCBvZwpEbGdrcN5Y29ycA + TAO:0002048 + larval organism + ammocoete + bipinnaria + caterpillar + glochidium + grub + leptocephalus + maggot + naiad + nymph + planula + tadpole + trochophore + veliger + wriggler + zoea + uberon + UBERON:0002548 + + larva + + + + + A distinct juvenile form many animals undergo before metamorphosis into adults. Animals with indirect development such as insects, amphibians, or cnidarians typically have a larval phase of their life cycle. + + + + + + Whole organism that is premetamorphic or a very immature individual.[TAO] + 2012-08-14 + TAO:0002048 + TAO + TAO:wd + + + + + larval organism + TAO:0002048 + + + + + ammocoete + + + + + + bipinnaria + + + + + + caterpillar + + + + + + glochidium + + + + + + grub + + + + + + leptocephalus + + + + + + maggot + + + + + + naiad + + + + + + nymph + + + + + + planula + + + + + + tadpole + + + + + + trochophore + + + + + + veliger + + + + + + wriggler + + + + + + zoea + + + + + @@ -118490,7 +118962,7 @@ massive inconsistencies between GO, MA, wikipedia. Part of pons in MA, but this leads to inconsistencies with ABA. - GO + GO https://github.com/obophenotype/mouse-anatomy-ontology/issues/58 @@ -119197,7 +119669,7 @@ VHOG:0000186 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 @@ -120478,7 +120950,7 @@ in XAO, develops from visceral pouch 2 - XAO + XAO @@ -120723,7 +121195,7 @@ VHOG:0000235 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 @@ -120955,7 +121427,7 @@ TODO - check that GO's optic placode is the same as ZFA's eye primordium; we may want to have separate term for ocular primordium precursor. XAO has both optic field and eye primordium. - GO + GO @@ -121450,7 +121922,7 @@ A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA] - ISBN:0815318960 + ISBN:0815318960 OMD:neural+plate ZFIN:curator @@ -121741,7 +122213,7 @@ - EHDAA2-abduced + EHDAA2-abduced @@ -121778,7 +122250,7 @@ in XAO this develops_from dorsolateral placode, but in NBK53175, this is a separate group - XAO + XAO @@ -121909,7 +122381,7 @@ EHDAA2 - VHOG + VHOG @@ -121933,7 +122405,7 @@ The portion of the mesoderm of the trunk of vertebrate embryos lying lateral to the intermediate mesoderm. [...] [It] subdivides into two plates: one dorsal, called the somatopleure, and one ventral, called the splanchnopleure. [Gastrulation:_From_cells_to_embryo_(2004)_Cold_Spring_Harbor, Glossary_XV, New_York:_Cold_Spring_Harbor_Laboratory_Press, Stern_CD][VHOG] 2012-09-17 VHOG:0000118 - VHOG + VHOG @@ -121942,7 +122414,7 @@ A ventrolateral zone of amphioxus mesoderm grows down to surround the gut. Homology of this zone to the lateral plate mesoderm of vertebrates is supported by site of origin and fate.[well established][VHOG] 2012-09-17 VHOG:0000118 - VHOG + VHOG DOI:10.1073/pnas.97.9.4449 Shimeld SM and Holland PW. Vertebrate innovations. PNAS (2000) @@ -122055,7 +122527,7 @@ - EHDAA2-abduced + EHDAA2-abduced @@ -122141,7 +122613,7 @@ Trunk portion of the neural crest. The trunk neural crest lies between the vagal and sacral neural crest and gives rise to two groups of cells. One group migrates dorsolateral and populates the skin, forming pigment cells and the other migrates ventrolateral through the anterior sclerotome to become the epinephrine-producing cells of the adrenal gland and the neurons of the sympathetic nervous system. Some cells remain in the sclerotome to form the dorsal root ganglia [Wikipedia]. - ISBN:0815318960 + ISBN:0815318960 @@ -122160,7 +122632,7 @@ VHOG:0000062 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 @@ -122482,7 +122954,7 @@ part_of somite in XAO - XAO + XAO @@ -122578,7 +123050,7 @@ - VHOG + VHOG @@ -122802,7 +123274,7 @@ VHOG:0000063 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 @@ -123379,7 +123851,7 @@ 2012-06-20 AAO:0010365 AAO - ISBN:0-02-377110-0 + ISBN:0-02-377110-0 @@ -123395,7 +123867,7 @@ in XAO, called branchial arch 1 and df VP3 - XAO + XAO @@ -123491,7 +123963,7 @@ 2012-06-20 AAO:0010366 AAO - ISBN:0-02-377110-0 + ISBN:0-02-377110-0 @@ -123507,7 +123979,7 @@ in XAO, called branchial arch 2 and df VP4 - XAO + XAO @@ -123605,7 +124077,7 @@ 2012-06-20 AAO:0010368 AAO - ISBN:0-02-377110-0 + ISBN:0-02-377110-0 @@ -123876,7 +124348,7 @@ 2012-06-20 AAO:0010418 AAO - ISBN:0-02-377110-0 + ISBN:0-02-377110-0 @@ -124013,7 +124485,7 @@ 2012-06-20 AAO:0010419 AAO - ISBN:0-02-377110-0 + ISBN:0-02-377110-0 @@ -124139,7 +124611,7 @@ 2012-06-20 AAO:0010420 AAO - ISBN:0-02-377110-0 + ISBN:0-02-377110-0 @@ -124272,7 +124744,7 @@ 2012-06-20 AAO:0010422 AAO - ISBN:0-02-377110-0 + ISBN:0-02-377110-0 @@ -124905,7 +125377,7 @@ GO uses genitalia for the singular organ - GO + GO @@ -125482,7 +125954,7 @@ - ISBN:9780878932504 + ISBN:9780878932504 @@ -151628,7 +152100,7 @@ - FMA-modified + FMA-modified @@ -151644,7 +152116,7 @@ - FMA-modified + FMA-modified @@ -152971,7 +153443,7 @@ VHOG:0000343 VHOG - ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 + ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 @@ -153145,7 +153617,7 @@ The middle limb segment of the pelvic free limb, between the autopod and stylopod segments. Includes as parts the hindlimb zeugopodial skeleton, which includes as parts the tibia and fibula, or their cartilage precursors, or evolutionary variants. - PHENOSCAPE:curators + PHENOSCAPE:curators @@ -153155,7 +153627,7 @@ VHOG:0000348 VHOG - ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 + ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 @@ -155324,7 +155796,7 @@ VHOG:0000796 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 @@ -155400,7 +155872,7 @@ VHOG:0000799 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 @@ -155463,7 +155935,7 @@ VHOG:0000798 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 @@ -155560,7 +156032,7 @@ VHOG:0001210 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 @@ -155630,7 +156102,7 @@ VHOG:0001006 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 @@ -160178,7 +160650,7 @@ - EHDAA2-abduced + EHDAA2-abduced @@ -160254,7 +160726,7 @@ - NCBIBook:NBK10047 + NCBIBook:NBK10047 @@ -160273,13 +160745,13 @@ germinal neuroepithelium - NCBIBook:NBK10047 + NCBIBook:NBK10047 original neural tube - NCBIBook:NBK10047 + NCBIBook:NBK10047 @@ -161126,7 +161598,7 @@ - NCBIBook:NBK10047 + NCBIBook:NBK10047 @@ -161137,7 +161609,7 @@ - NCBIBook:NBK10047 + NCBIBook:NBK10047 @@ -161156,19 +161628,19 @@ ependymal layer - NCBIBook:NBK10047 + NCBIBook:NBK10047 neural tube ependymal layer - NCBIBook:NBK10047 + NCBIBook:NBK10047 neural tube ventricular germinal zone - NCBIBook:NBK10047 + NCBIBook:NBK10047 @@ -161230,7 +161702,7 @@ - NCBIBook:NBK10047 + NCBIBook:NBK10047 @@ -161242,7 +161714,7 @@ by division - NCBIBook:NBK10047 + NCBIBook:NBK10047 @@ -163677,7 +164149,7 @@ this term denotes the primary heart field; GO:0003128 denotes the superclass of primary and secondary: specific region of the lateral mesoderm into the area which will form the primary beating heart tube[GO:0003138] - GO + GO @@ -174067,7 +174539,7 @@ - ISBN:9780878932504 + ISBN:9780878932504 @@ -174075,7 +174547,7 @@ An outgrowth on the lateral trunk of the embryo that develops into a limb. The limb bud is divided into ectoderm and mesenchyme[cjm, modified from MP]. - ISBN:9780878932504 + ISBN:9780878932504 MP:0005650 @@ -174542,7 +175014,7 @@ One of a series of paired embryological vascular structures formed within a pharyngeal arch; in the adult, some of these vessels give rise to the great vessels[MP] - MP:0002672 + MP:0002672 @@ -174562,7 +175034,7 @@ VHOG:0000122 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 @@ -174574,7 +175046,7 @@ PAA - MP:0002672 + MP:0002672 @@ -174608,13 +175080,13 @@ embryonic aortic arch artery EMAPA:16684 - MP:0002672 + MP:0002672 pharyngeal arch artery - MP:0002672 + MP:0002672 @@ -176601,13 +177073,13 @@ A vertebra in the trunk or cervical region. Includes all cervical, thoracic and lumbar vertebrae, but excludes caudal vertebra. - UBERONREF:0000006 + UBERONREF:0000006 it's not clear if the XAO class belongs here or below - XAO + XAO @@ -178725,7 +179197,7 @@ in GO, this is equivalent to the atrial myocardium, but FMA distinguishes these two. Consider merging. - GO + GO @@ -179420,7 +179892,7 @@ 2012-08-14 VSAO:0000180 VSAO - TAO:curator + TAO:curator @@ -184223,7 +184695,7 @@ Any of the veins that parallel the arcuate arteries, receive blood from the interlobular veins and straight venules, and terminate in the interlobar veins. ISBN:0-683-40008-8 - MP:0011325 + MP:0011325 @@ -184235,19 +184707,19 @@ arciform vein of kidney - MP:0011325 + MP:0011325 arcuate vein of kidney - MP:0011325 + MP:0011325 renal arcuate vein - MP:0011325 + MP:0011325 @@ -185265,7 +185737,7 @@ GO treats glomus and pronephric glomerulus differently - GO + GO @@ -185415,7 +185887,7 @@ 2012-08-14 TAO:0000191 TAO - TAO:GA_TG + TAO:GA_TG @@ -185556,7 +186028,7 @@ 2012-08-14 TAO:0001455 TAO - TAO:GA_TG + TAO:GA_TG ZFIN:curator @@ -202790,7 +203262,7 @@ in GO, covers optic, otic, olfactory, mammary, hair, tooth, sebaceous - and also insect structures - GO + GO @@ -204600,7 +205072,7 @@ - ISBN:9780878932504 + ISBN:9780878932504 @@ -208066,7 +208538,7 @@ Portion of primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells. - ISBN:0683400088 + ISBN:0683400088 MP:0011260 @@ -210398,7 +210870,7 @@ XAO/AAO class belongs here, as it refers to mesonephric structure - XAO + XAO @@ -210953,7 +211425,7 @@ - NCBIBook:NBK10047 + NCBIBook:NBK10047 @@ -211279,7 +211751,7 @@ Layer that is part of the CA fields of the hippocampus consisting of a narrow relatively cell free layer located deep to the pyramidal cell layer extending through areas CA1, CA2 and CA3. (adapted from Paxinos The rat central nervous system, 2nd ed, Academic Press, San Diego, 1995) BAMS:Or - BIRNLEX:4113 + BIRNLEX:4113 EMAPA:35412 FMA:83893 MA:0000958 @@ -211300,43 +211772,43 @@ Layer that is part of the CA fields of the hippocampus consisting of a narrow relatively cell free layer located deep to the pyramidal cell layer extending through areas CA1, CA2 and CA3. (adapted from Paxinos The rat central nervous system, 2nd ed, Academic Press, San Diego, 1995) - BIRNLEX:4113 + BIRNLEX:4113 http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=157 - BIRNLEX:4113 + BIRNLEX:4113 oriens layer of hippocampus - BIRNLEX:4113 + BIRNLEX:4113 oriens layer of the hippocampus - BIRNLEX:4113 + BIRNLEX:4113 polymorphic layer of hippocampus - BIRNLEX:4113 + BIRNLEX:4113 polymorphic layer of the hippocampus - BIRNLEX:4113 + BIRNLEX:4113 stratum oriens - BIRNLEX:4113 + BIRNLEX:4113 @@ -213967,7 +214439,7 @@ VHOG:0001260 VHOG - ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 + ISBN:978-0198540472 Janvier P, Early vertebrates (1996) p.268 @@ -214723,7 +215195,7 @@ VHOG:0001208 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 @@ -216398,7 +216870,7 @@ VHOG:0001372 VHOG - DOI:10.1016/S0959-4388(99)00003-3 Holland LZ and Holland ND, Chordate origins of the vertebrate central nervous system. Current Opinion in Neurobiology (1999) + DOI:10.1016/S0959-4388(99)00003-3 Holland LZ and Holland ND, Chordate origins of the vertebrate central nervous system. Current Opinion in Neurobiology (1999) @@ -216709,7 +217181,7 @@ VHOG:0000269 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 @@ -216874,7 +217346,7 @@ VHOG:0000268 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 @@ -217321,7 +217793,7 @@ we place the XAO structure here for now. In terms of analagy, it is more closely related to common iliac, but the relationships currently attached to this class are mammal specific - XAO + XAO @@ -219738,14 +220210,14 @@ - ISBN:9780878932504 + ISBN:9780878932504 ZFA-inferred A ring of cells capable of forming a limb or paired fin[Gilbert,modified]. - ISBN:9780878932504 + ISBN:9780878932504 @@ -221390,7 +221862,7 @@ VHOG:0000264 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.620 @@ -221900,7 +222372,7 @@ isa cell condensation in VSAO; has_part chondroblast in AEO - VSAO + VSAO @@ -222319,7 +222791,7 @@ A groove that is situated between the 1st and 2nd pharyngeal arch. - ISBN:0124020607 + ISBN:0124020607 VHOG:OG @@ -222450,7 +222922,7 @@ A groove that is situated between the 2nd and 3rd pharyngeal arch. - ISBN:0124020607 + ISBN:0124020607 VHOG:OG @@ -222571,7 +223043,7 @@ A groove that is situated between the 3rd and 4th pharyngeal arch. - ISBN:0124020607 + ISBN:0124020607 VHOG:OG @@ -225840,7 +226312,7 @@ We follow XAO is distinguishing the tail region from the tail; the tail bud is part of the tail region; the tail starts after the tail bud - XAO + XAO @@ -225951,7 +226423,7 @@ 2012-06-20 AAO:0000092 AAO - AAO:Duellman_and_Trueb_1994 + AAO:Duellman_and_Trueb_1994 @@ -226077,7 +226549,7 @@ 2012-06-20 AAO:0000612 AAO - AAO:Duellman_and_Trueb_1994 + AAO:Duellman_and_Trueb_1994 @@ -226165,7 +226637,7 @@ Subdivision of vertebral column that corresponds to the caudal subdivision of the body, containing the caudal vertebrae. - UBERONREF:0000006 + UBERONREF:0000006 @@ -226174,7 +226646,7 @@ 2012-06-20 AAO:0000082 AAO - AAO:Duellman_and_Trueb_1994 + AAO:Duellman_and_Trueb_1994 @@ -226192,7 +226664,7 @@ caudal skeleton - UBERONREF:0000006 + UBERONREF:0000006 @@ -228506,7 +228978,7 @@ A sac-like cavity ventral to the liver, lying in the sub-mesodermal space and closed by a thin sheet of ectodermal cells, from which the future gall bladder develops. - ISBN:0815318960 + ISBN:0815318960 XAO:0004205 @@ -229242,7 +229714,7 @@ Each of the canals that links the peritoneal cavity and the caudal part of a pleural cavity. - ISBN:0124020607 + ISBN:0124020607 VHOG:0001505 @@ -229577,7 +230049,7 @@ - EHDAA2-abduced + EHDAA2-abduced ZFA @@ -234346,7 +234818,7 @@ 2012-08-14 VSAO:0005019 VSAO - VSAO:NI + VSAO:NI @@ -234377,7 +234849,7 @@ autopodium VSAO:0005019 - VSAO:NI + VSAO:NI @@ -235892,7 +236364,7 @@ This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells[GO] keep this grouping class so long as it is required for GO All craniates have groups of cells homologous to the mammalian adrenocortical and chromaffin tissues, but they are scattered in and near the kidneys in fishes. (...) The cortical and chromaffin tissues come together to form adrenal glands in tetrapods.[well established][VHOG] - VHOG:0001141 + VHOG:0001141 adrenal gland - interrenal gland adrenal gland/interrenal tissue uberon @@ -235914,7 +236386,7 @@ All craniates have groups of cells homologous to the mammalian adrenocortical and chromaffin tissues, but they are scattered in and near the kidneys in fishes. (...) The cortical and chromaffin tissues come together to form adrenal glands in tetrapods.[well established][VHOG] 2012-09-17 - VHOG:0001141 + VHOG:0001141 VHOG ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.518 and Figure 15-9 @@ -235923,19 +236395,19 @@ adrenal gland - interrenal gland - VHOG:0001141 + VHOG:0001141 adrenal - interrenal gland - VHOG:0001141 + VHOG:0001141 suprarenal gland - interrenal gland - VHOG:0001141 + VHOG:0001141 @@ -238256,7 +238728,7 @@ VHOG:0000244 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.510 and Figure 15-5 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.510 and Figure 15-5 @@ -239173,7 +239645,7 @@ A pharyngeal pouch that is between pharyngeal arches 1 and 2. - ISBN:0124020607 + ISBN:0124020607 VHOG:0000970 @@ -239368,7 +239840,7 @@ A pharyngeal puch that is between the pharyngeal arches 2 and 3. - ISBN:0124020607 + ISBN:0124020607 @@ -239563,7 +240035,7 @@ A pharyngeal pouch that between pharyngeal arches 3 and 4. - ISBN:0124020607 + ISBN:0124020607 @@ -239679,7 +240151,7 @@ Portion of tissue that consists of the precursors of the pronephric glomus or glomerulus; derived from the medial portion of the pronephric intermediate mesoderm. - ISBN:0815318960 + ISBN:0815318960 @@ -240242,7 +240714,7 @@ - EMAPA-modified + EMAPA-modified @@ -240323,7 +240795,7 @@ - EMAPA-modified + EMAPA-modified @@ -240419,7 +240891,7 @@ - EMAPA-modified + EMAPA-modified @@ -241819,7 +242291,7 @@ 2012-08-14 TAO:0000258 TAO - TAO:curator + TAO:curator @@ -245554,7 +246026,7 @@ - VHOG + VHOG @@ -252385,7 +252857,7 @@ VSAO labels this term 'pharyngeal arch' (2012-06-01) - however, it clearly means pharyngeal arch skeleton. - VSAO + VSAO @@ -254265,7 +254737,7 @@ This class was created in order to align KUPO with CL. The original class was undefined, and the intended meaning is not clear, may be obsoleted in future. The vasa recta is parallel to the loop of Henles, this may refer to the portion of the vasa recta in the inner medullar parallel to the descending limb - CL + CL @@ -254302,7 +254774,7 @@ This class was created in order to align KUPO with CL. The original class was undefined, and the intended meaning is not clear, may be obsoleted in future. The vasa recta is parallel to the loop of Henles, this may refer to the portion of the vasa recta in the outer medullar parallel to the descending limb - CL + CL @@ -254339,7 +254811,7 @@ This class was created in order to align KUPO with CL. The original class was undefined, and the intended meaning is not clear, may be obsoleted in future. The vasa recta is parallel to the loop of Henles, this may refer to the portion of the vasa recta parallel to the ascending limb - CL + CL @@ -254376,7 +254848,7 @@ This class was created in order to align KUPO with CL. The original class was undefined, and the intended meaning is not clear, may be obsoleted in future. The vasa recta is parallel to the loop of Henles, this may refer to the portion of the vasa recta in the inner medulla parallel to the ascending limb - CL + CL @@ -254413,7 +254885,7 @@ This class was created in order to align KUPO with CL. The original class was undefined, and the intended meaning is not clear, may be obsoleted in future. The vasa recta is parallel to the loop of Henles, this may refer to the portion of the vasa recta in the outer medulla parallel to the ascending limb - CL + CL @@ -255607,7 +256079,7 @@ This class was created in order to align KUPO with CL. The original class was undefined, and the intended meaning is not clear, may be obsoleted in future. The vasa recta is parallel to the loop of Henles, this may refer to the portion of the vasa recta parallel to the descending limb - CL + CL @@ -257841,7 +258313,7 @@ Subdivision of vertebral column that corresponds to the trunk of the body, containing the trunk/presacral vertebrae. In organisms that have a thoracic and lumbar distinction, this corresponds to the sum of both of these regions. - UBERONREF:0000006 + UBERONREF:0000006 @@ -257850,7 +258322,7 @@ 2012-06-20 AAO:0000612 AAO - AAO:Duellman_and_Trueb_1994 + AAO:Duellman_and_Trueb_1994 @@ -262236,7 +262708,7 @@ 2012-08-14 VSAO:0005022 VSAO - VSAO:NI + VSAO:NI @@ -262251,7 +262723,7 @@ basipodium skeleton VSAO:0005022 - VSAO:NI + VSAO:NI @@ -262276,14 +262748,14 @@ basipodium VSAO:0005022 - VSAO:NI + VSAO:NI mesopodium VSAO:0005022 - VSAO:NI + VSAO:NI @@ -264953,7 +265425,7 @@ The dorsal portion of the embryonic first endodermal pharyngeal pouch; it develops into the middle ear cavity. - ISBN:0124020607 + ISBN:0124020607 VHOG:0001297 @@ -267712,7 +268184,7 @@ isa blood vessel in XAO - XAO + XAO @@ -269847,7 +270319,7 @@ - EHDAA2-abduced + EHDAA2-abduced @@ -272774,7 +273246,7 @@ - VHOG + VHOG @@ -273598,7 +274070,7 @@ 2012-08-14 VSAO:0005025 VSAO - VSAO:NI + VSAO:NI @@ -273639,7 +274111,7 @@ metapodium VSAO:0005025 - VSAO:NI + VSAO:NI @@ -274646,10 +275118,10 @@ It is still called a complex when one of the two parts is missing (?) There are fossil fishes with only an outgrowth (no record of a girdle), including thelodonts (which have a suprabranchial fin) as well as some anaspids which have a distinctive 'paired fin' (with differing published assertions on whether it's homologous to a pec fin or pelvic fin or both or neither). There are many fishes and other vertebrates with only a girdle and no outgrowth.[VSAO] - 2012-09-06 + 2012-09-06 VSAO:0000214 VSAO - Curator + Curator @@ -275149,7 +275621,7 @@ skeleton cruris - NominaAnatomicaVeterinaria:2005 + NominaAnatomicaVeterinaria:2005 @@ -279611,7 +280083,7 @@ - EHDAA2-abduced + EHDAA2-abduced @@ -280268,7 +280740,7 @@ The part of the trunk that is in the dorsum[cjm]. - UBERONREF:0000006 + UBERONREF:0000006 @@ -281076,7 +281548,7 @@ - ISBN:9780878932504 + ISBN:9780878932504 @@ -281140,7 +281612,7 @@ Proximal element of the limb skeleton consisting of the femur and humerus in the forelimb stylopodium and hindlimb stylopodium respectively.[VSAO] propodial stylopodial - VSAO:0005007 + VSAO:0005007 stylopodium skeleton uberon mesomere 1 @@ -281167,16 +281639,16 @@ Proximal element of a free limb skeleton consisting of the femur and humerus in the forelimb stylopodium and hindlimb stylopodium respectively[VSAO, modified]. - VSAO:0005007 + VSAO:0005007 Proximal element of the limb skeleton consisting of the femur and humerus in the forelimb stylopodium and hindlimb stylopodium respectively.[VSAO] 2012-08-14 - VSAO:0005007 + VSAO:0005007 VSAO - VSAO:NI + VSAO:NI @@ -281189,7 +281661,7 @@ propodium - VSAO:0005007 + VSAO:0005007 @@ -281202,7 +281674,7 @@ stylopod - VSAO:0005007 + VSAO:0005007 @@ -281924,7 +282396,7 @@ A vertebra in the trunk region. For tetrapods, includes lumbar and thoracic vertebrae. Excludes caudal/coccygeal vertebra, which are located posteriorly. In tetrapods this includes thoracic, lumbar and sacral vertebrae, and excludes the cervical vertebrae, which are located anteriorly. - UBERONREF:0000006 + UBERONREF:0000006 @@ -296898,7 +297370,7 @@ - VHOG + VHOG @@ -298676,7 +299148,7 @@ The major preaxial endochondral element in the posterior zeugopod[Phenoscape]. - PHENOSCAPE:mah + PHENOSCAPE:mah @@ -311479,7 +311951,7 @@ The epithelial layer covering the biliary system. This includes the epithelium of the gallbladder (when present) as well as the intrahepatic and extrahepatic bile ducts. BTO:0001513 - MGI:cs + MGI:cs @@ -311693,7 +312165,7 @@ - VHOG + VHOG @@ -312675,7 +313147,7 @@ - EMAPA-modified + EMAPA-modified @@ -312733,7 +313205,7 @@ - EMAPA-modified + EMAPA-modified @@ -320386,6 +320858,181 @@ + + + + + + + + + + + + + + + + + + + + + + Any head that is part of some larva. + FBbt:00001730 + uberon + UBERON:6001730 + insect larval head + + + + + Any head that is part of some larva. + FBC:auto_generated_definition + + + + + + + + + + + + + + + + + + + + + + + + + + Any sense organ that is part of some larva. + FBbt:00002639 + larval sense organ + uberon + UBERON:6002639 + insect larval sense organ + + + + + Any sense organ that is part of some larva. + FBC:auto_generated_definition + + + + + + + + + + + + + + + + + + + + + Any sensillum (UBERON:6007152) that is part of some larva (UBERON:6001727). + FBbt:00007240 + larval sensillum + uberon + UBERON:6007240 + insect embryonic/larval sensillum + + + + + Any sensillum (UBERON:6007152) that is part of some larva (UBERON:6001727). + FBC:auto_generated_definition + + + + + + + + + + + + + + + + + + + + + + Any sensillum (UBERON:6007152) that is part of some larval head (UBERON:6001730). + FBbt:00007242 + larval head sensillum + uberon + UBERON:6007242 + insect embryonic/larval head sensillum + + + + + Any sensillum (UBERON:6007152) that is part of some larval head (UBERON:6001730). + FBC:auto_generated_definition + + + + + + + + + + + + + + + + + + + + + + + + + + Any sense organ (UBERON:6005155) that is part of some larval head (UBERON:6001730). + FBbt:00007280 + larval head sense organ + uberon + UBERON:6007280 + insect embryonic/larval head sense organ + + + + + Any sense organ (UBERON:6005155) that is part of some larval head (UBERON:6001730). + FBC:auto_generated_definition + + + + diff --git a/src/ontology/imports/uberon_terms.txt b/src/ontology/imports/uberon_terms.txt index 9548b2746..d0a0ebcc7 100644 --- a/src/ontology/imports/uberon_terms.txt +++ b/src/ontology/imports/uberon_terms.txt @@ -1,4 +1,5 @@ UBERON:0001062 UBERON:0022315 UBERON:0004024 -UBERON:0004026 \ No newline at end of file +UBERON:0004026 +UBERON:0002548 diff --git a/src/ontology/reports/basic-report.tsv b/src/ontology/reports/basic-report.tsv index a63b72742..c0e4bb693 100644 --- a/src/ontology/reports/basic-report.tsv +++ b/src/ontology/reports/basic-report.tsv @@ -22,6 +22,7 @@ "A brush cell found in the epithelium of lobular bronchiole." "FMA:263220" "An extracellular matrix secreting cell that secretes collagen." "Granule cell that is part of the olfactory bulb." + "A GABAergic cortical interneuron that develops from the medial ganglionic eminence and has migrated to the cerebral cortex." "A fibroblast that is part of the connective tissue of glandular part of prostate." "FMA:261283" "Obsolete. Use PO:0000274 from Plant Ontology instead. A fiber of the xylem tissue, Two types are recognized in the secondary xylem: fiber tracheids and libriform fibers." "Obsolete. Use PO:0004010 from Plant Ontology instead. A cell synthesizing protoplasm and producing new cells by division and with only a primary cell wall." @@ -43,7 +44,6 @@ "A paneth cell that is located in the epithelium of the large intestine." "A neuronal receptor that respond to mechanical pressure or distortion in the skin." - "BTO:0002316" "An epithelial cell of the tracheobronchial tree." "FMA:66816" "A type II pneumocyte is a pneumocyte that modulates the fluid surrounding the alveolar epithelium by secreting and recycling surfactants. This cell type also contributes to tissue repair and can differentiate after injury into a type I pneumocyte. Thicker than squamous alveolar cells, have a rounded apical surface that projects above the level of surrounding epithelium. The free surface is covered by short microvilli." "BTO:0000538 FMA:62501" "Any dopaminergic neuron that is part of a midbrain." @@ -56,16 +56,20 @@ "An epithelial cell of the mucosa associated with facial skeleton." "FMA:70581" "A small, polyhedral, cell found in rounded groups or curved columns with deeply staining nuclei, scanty basophilic cytoplasm and a few lipid droplets. This cell in the zona glomerulosa produces mineralocorticoids." "FMA:69273" "Any neuron that is part of a lateral line ganglion." + "An excitatory glutamatergic neuron transcriptomically related to the CT subclass, with a soma preferentially located in the bottom of L6 of the primary motor cortex." + "A GABAergic cortical interneuron that is strongly labelled for α7 nAChRs. These cells have soma found in L1 and have multipolar dendrites with vertically descending axonal collaterals that project deep into the column, usually branching and terminating in L5A." "A basal cell found in the bronchus epithelium." "FMA:263120" "A NK1.1-positive T cell that is CD94-positive." "An immature microglial cell with a ramified morphology." + "A L2/3 Pvalb-like Sst GABAergic cortical interneuron (Mus musculus) that has Martinotti morphology." "A pre-BCR-positive precursor B cell that is CD24-high, CD25-positive, CD43-positive, CD45R-positive and BP-positive." "A conventional dendritic cell that is CD103-positive. This cell type is usually found in non-lymphoid tissue." "An epithelial cell with a well defined Golgi apparatus that makes up the continuous layer of cells bordering the thymic tissue beneath the capsule." "FMA:72209" "A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells." "KUPO:0001074" + "A near-projecting glutamatergic neuron with a soma found in layer 5/6 of the primary motor cortex." "ILX:0770161" "A short lived plasma cell that secretes IgM." "A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1." "A class switched memory B cell that expresses IgA." @@ -80,6 +84,7 @@ "A steroid hormone secreting cell that secretes androgen." "An immature myeloid leukocyte of heterogeneous phenotype found particularly in cancer and sepsis patients that is capable of suppressing activity of T cells in ex vivo assays. This cell type is CD45-positive, CD11b-positive." "A cell in the area of mesoderm in the neurulating embryo that flanks and forms simultaneously with the neural tube. The cells of this region give rise to somites." + "A Betz cell that synapses with lower motor neurons directly." "A zygote in a plant or an animal." "A specialized hair cell that has an elongated kinocilium upon which an otolith accretes. The tether cell then anchors the otolith in place." "A lymphocyte of B lineage that is capable of B cell mediated immunity." "VHOG:0001480 CALOHA:TS-0068 BTO:0000776 FMA:62869" @@ -103,7 +108,6 @@ "A basal cell that is part of the epithelium of bronchiole." "FMA:263126" "A long-lived, antigen-experienced T cell that has acquired a memory phenotype including distinct surface markers and the ability to differentiate into an effector T cell upon antigen reexposure." "BTO:0003435" "A cell with a flagellum surrounded by a collar of microvilli. The motion of the flagellum draws water past the microvilli, serving either a feeding or sensory function. Collar cells are found in multiple animals, including sponges, echinoderms, and cnidarians. They are also found outside animals in the choanoflagellates. Although collar cells are superficially similar, their cytoskeletal structure and functional biology are different in different groups of organisms." - "A Sst GABAergic cortical interneuron that is found in L5 and possesses 'T-shaped' martinotti morphologies with local axonal plexus in L5a and translaminar axons restricted to the uppermost part of L1. They show low-threshold spiking patterns with strong rebound firing, and inhibit the L1 apical tuft of nearby pyramidal cells." "A plasmacytoid dendritic cell developing in the thymus with phenotype CD11c-negative or low, CD45RA-positive, CD11b-negative, and CD123-positive." "A CD11c-low plasmacytoid dendritic cell that is CD8alpha-positive and CD4-positive." "A hematopoietic stem cell that exists during embryogenesis." @@ -114,6 +118,7 @@ "Skeletogenic cell that has the potential to develop into a cementoblast." "A double negative post-natal thymocyte that has a T cell receptor consisting of a gamma chain containing a Vgamma2 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-positive." "A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped." "BTO:0000452 VHOG:0001482 FMA:63877 CALOHA:TS-0362" + "A stromal cell found in the lamina propria of the vermiform appendix." "An epithelial cell of the musculomembranous digestive tube extending from the mouth to the anus." "A serous secreting cell that is part of the epithelium of bronchiole." "FMA:263084" @@ -134,6 +139,7 @@ "A mature NK cell that is NK1.1-positive." "Undifferentiated; mitotic stem cell for other epithelial cell types; rounded or elliptical with little cytoplasm and few organelles; contain cytokeratin intermediate filament." "FMA:62516 BTO:0000939" "A late basophilic metamyelocyte in which the nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature basophil." + "A glutamatergic neuron with a soma found in cortical layer 6b. They are transcriptomically related to corticothalamic-projecting neurons but have differential projections to the thalamus or anterior cingulate." "ILX:0770163" "An ecto-epithelial cell of the buccal region of the viscerocranial mucosa." "FMA:70577" "A small medullary thymic epithelial cell with a spindle shape, often arranged in groups and connected to each other by large desmosomes and interdigitations. The cytoplasm is sparse, with scanty organelles and thick bundles of cytokeratin." "An enteroendorcine cell found in the fundus and pylorus, this cell type has dense round secretory granules that contain ghrelin." "FMA:63209" @@ -145,12 +151,13 @@ "Hematopoietic cells resident in the bone marrow. Include: hematopoietic stem cells (lymphoid stem cells and myeloid stem cells) and the precursor cells for thrombocytes, erythrocytes, basophils, neutrophils, eosinophils, monocytes and lymphocytes." "CALOHA:TS-2109" "Obsolete. Use PO:0000075 from Plant Ontology instead. An elongated living cell with unevenly thickened nonlignified primary walls." - "An epithelial cell of the hypodermis of flatworms." "WBbt:0007846" "A lymphocyte that resides in the lamina propria of the large intestine." + "A neuron that has dendritic processes radiating from the cell body forming a star-like shape." "BTO:0002316" "Transit-amplifying cells (TACs) are an undifferentiated population in transition between stem cells and differentiated cells." "A mature CD1a-positive dermal dendritic cell is CD80-high, CD83-positive, CD86-high, and MHCII-high." "A glandular cell found in the epithelium of the small intestine. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Somatostatin-secreting Cells (D-cells) ." "CALOHA:TS-1286 FMA:86928" "FBbt:00005063" + "A Sst GABAergic cortical interneuron with a soma found in L5 and possesses 'T-shaped' martinotti morphologies with local axonal plexus in L5a and translaminar axons restricted to the uppermost part of L1. They show low-threshold spiking patterns with strong rebound firing, and inhibit the L1 apical tuft of nearby pyramidal cells." "An immature CD1a-positive dermal dendritic cell is CD80-low, CD86-low, and MHCII-low." "KUPO:0001020" "An epithelial cell found in C. elegans that firmly hold the outer body wall and the lips to the inner cylinder of the pharynx in a manner that keeps these organs from breaking apart, while still giving each organ freedom of movement during feeding." "WBbt:0005793" @@ -205,9 +212,11 @@ "A CD38-positive naive B cell is a mature B cell that has the phenotype CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery." "An epithelial cell of the cornea." "FMA:70551 BTO:0004298 CALOHA:TS-0173" + "A dendritic cell that is located in a vermiform appendix." "Any osteoblast that is part of a skull." "A fully differentiated basophil, a granular leukocyte with an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation." "CALOHA:TS-0688 BTO:0001026" "A hematopoietic stem cell with long term self renewal capability. This cell is Kit-positive, Sca1-positive, CD150-positive, CD90-low, CD34-negative and Flt3-negative." + "A mesothelial fibroblast found in the leptomeninx." "KUPO:0001047" "Notochordal cell that is inner portion of the notochord and becomes vacuolated as development proceeds." "A secondary lymphoid organ macrophage found in the spleen." "FMA:83026" @@ -219,6 +228,7 @@ "KUPO:0001064" "A smooth muscle cell derived from the neural crest." "A pre-BCR positive B cell that is CD38-high." + "A macrophage located in the vermiform appendix." "An epithelial cell found in the lining of the stomach." "FMA:62948" "A skeletal muscle cell that has become mitotically active - typically following muscle damage." "A thymocyte found in the fetal thymus." @@ -241,6 +251,7 @@ "KUPO:0001090" "A type of intrafusal muscle fiber that lies in the center of a muscle spindle. Nuclei are clustered centrally and give the equatorial region a swollen appearance. They are associated with associated with dynamic gamma motor neurons, and the stretching of the equatorial region of the nuclear bag fibers results in an increase in the firing rate of type Ia sensory fibers." "A group 1 innate lymphoid cell that is non-cytotoxic." + "A pyramidal neuron which has an apical tree which is oriented towards the white matter." "A cell that takes up and metabolizes substances." "A CD8-positive, alpha beta memory T cell with the phenotype CD45RA-positive, CD45RO-negative, and CCR7-negative." "An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." "BTO:0000751 FMA:62852 CALOHA:TS-0549" @@ -259,6 +270,7 @@ "A CD38-positive IgG-negative memory B cell is an IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-positive and IgG-negative." "A macroconidium that has more than one nucleus." "FAO:0000035" "A NK1.1-positive T cell that is CD94-positive and Ly49Cl-positive." + "ILX:0777212 A type of interneuron that has two clusters of dendritic branches that originate directly from the soma and extend in opposite directions and axons that form a plexus which spreads widely. Compared to bipolar neurons, bitufted neurons have branching that occur close to the soma." "A mucus-secreting cell, with numerous apical secretory vesicles containing mucins; nucleus are basally displaced; numerous at the neck of mucus secreting glands" "A trophoblast cell that arises in the junctional zone (basal plate) of the placenta." @@ -298,6 +310,7 @@ "KUPO:0001081" "KUPO:0001037" "KUPO:0001089" + "An intestinal crypt stem cell that is located in the vermiform appendix. These stem cells reside at the bottom of crypts in the appendix and are highly proliferative. They either differentiate into transit amplifying cells or self-renew to form new stem cells." "A germinal center B cell that is rapidly dividing and has the phenotype IgD-negative, CD38-positive, and CD77-positive. Somatic hypermutation of the immunoglobulin V gene region can occur during proliferation of this cell type." "A serous secreting cell that is part of the epithelium of trachea." "FMA:263078" "A cell of the embryo." "WBbt:0007028 FMA:82840 FMA:82841 CALOHA:TS-0263" @@ -347,6 +360,7 @@ "A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells." "FMA:83621 BTO:0004850" "A subset of motor neurons that innervates intrafusal muscle fibers and has small diameter axons." + "A cell of the middle germ layer of the embryo." "FMA:72554" "OBSOLETE (was not defined before being made obsolete)." "A thymocyte that has a T cell receptor consisting of a gamma chain that does not contain the Vgamma2 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-negative." @@ -365,7 +379,6 @@ "An epithelial cell of the pancreas." "BTO:0000028" "Immature CD11c-low plasmacytoid dendritic cell is a CD11c-low plasmacytoid dendritic cell that is CD80-low and CD86-low." - "A Vip GABAergic cortical interneuron found in L5. L5 Vip cells have mostly local morphology with some deep-projecting axons. They show only moderate resistance, comparable to that of Sst subclass and unlike typical Vip subclass cells that tend to show high input resistance. L5 Vip cells show particularly low resting membrane potential." "A cell that lines the trabecular meshwork, which is an area of tissue in the eye located around the base of the cornea, near the ciliary body, and is responsible for draining the aqueous humor from the eye via the anterior chamber (the chamber on the front of the eye covered by the cornea). This cell may play a role in regulating intraocular pressure." "A neuron that releases dopamine as a neurotransmitter." "WBbt:0006746 FMA:84787 BTO:0004032" "A large, progesterone secreting cell in the corpus luteum that develops from the granulosa cells." "FMA:18689" @@ -376,7 +389,6 @@ "A cell that lacks a nucleus." "FMA:68647" "Neuromast mantle cell is a non-sensory cell. Neuromast mantle cells surround the neuromast support cells and neuromast hair cells, separating the neuromast from the epidermis, and secrete cupula in which the ciliary bundles of all the hair cells are embedded." "A type II NK T cell that has been recently activated, secretes interferon-gamma, and has the phenotype CD69-positive and downregulated NK markers." - "A Sst GABAergic cortical interneuron that is found in lower L2/3 and upper 5, L4 Sst cells have martinotti morphology with ascending axons but denser local axons and sparser ‘fanning-out’ projections to L1. L4 Sst cells have smaller membrane time constant to calb2 (L2/3/5 Fan Martinotti Cell) and non-zero afterdepolarization (ADP)." "OBSOLETE (was not defined before being made obsolete)." "Any endothelial cell of artery that is part of a coronary artery." @@ -398,6 +410,7 @@ "A lymph node macrophage found in the cortex of lymph nodes, in particular in and around the germinal centers, and that participates in phagocytosis of apoptotic B cells from the germinal centers." "An enucleate erythrocyte that is Lyg-76-high." "An undifferentiated columnar cell of the bronchus epithelium" + "An epithelial cell of the hypodermis of Caenorhabditis." "WBbt:0007846" "An epithelial cell of the parathyroid gland." "FMA:70547" "Glandular cell of colon epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells." "CALOHA:TS-1274" "Nucleus with two or more lobes connected by a thin filament that contains no internal chromatin." @@ -453,8 +466,10 @@ "Epidermal cells that do not contain keratin. Cell type is usually associated with moist epidermal tissues." "FMA:62880" "OBSOLETE: A classification of cells by the number of their nuclei." "A crenated erythrocyte with 30+ crenations, bumps or spurs that are the result of damage due to age or disease." "FMA:81099" + "A L2/3 Pvalb-like Sst GABAergic cortical interneuron (Mus musculus) that has basket morphology." "An endothelial stalk cell is a specialized endothelial cell that follows behind the tip cell of an angiogenic sprout." "A fungal cell with two genetically distinct haploid nuclei." + "KUPO:0001082" "A myoepithelial cell that is part of the mammary gland alveolus." "FMA:67802" @@ -514,6 +529,7 @@ "Cell of the nasopharyngeal epithelium." "CALOHA:TS-2398" "A cell type found in the gastrointestinal and respiratory tracts that is characterized by the presence of a tuft of blunt, squat microvilli (120-140 per cell). Function of this cell type is not known." "FMA:67978" + "An enterocyte that is a part of a vermiform appendix." "A thymocyte that has a T cell receptor consisting of a gamma chain containing Vgamma2 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-negative." "OBSOLETE: A cell line cell that is expected to be capable of an unlimited number of divisions, and is thus able to support indefinite growth/propagation in vitro as part of a immortal cell line." "A M cell that is part of the epithelium of small intestine." "FMA:263128" @@ -525,14 +541,13 @@ "A NK1.1-positive T cell that is Ly49D-positive." "A large, oval stomach epithelial cell with a central nucleus; source of gastric acid. Secretes HCl." "BTO:0001780 FMA:62901" "A terminally differentiated, post-mitotic, antibody secreting cell of the B cell lineage with the phenotype CD138-positive, surface immunonoglobulin-negative, and MHC Class II-negative. Plasma cells are oval or round with extensive rough endoplasmic reticulum, a well-developed Golgi apparatus, and a round nucleus having a characteristic cartwheel heterochromatin pattern and are devoted to producing large amounts of immunoglobulin." "FMA:70574 BTO:0000392" + "A Betz cell that syanpses with spinal interneurons." "A mature B cell that produces cytokines that can influence CD4 T cell differentiation." "An eosinophil with a ring-shaped nucleus that is resident in the lung parenchyma. In mouse, lung parenchyma resident eosinophils are IL-5-independent Siglec-F(intermediate) CD62L+ CD101(low). In human, they are Siglec-8+ CD62L+ IL-3R(low)." "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The cell has a diffuse axon terminal with varicosities in sublaminae 1 and 2 of the inner plexiform layer." "A precursor B cell that is CD45RA-positive, CD43-positive, CD24-positive and BP-1-negative." - "A Sst GABAergic cortical interneuron that is found in lower L5 with mostly local axonal arborization but with some sparse ascending axons. L5 Non-martinotti Sst cells show somatic localization and local axon plexus in L5b and L5b/6 and substantial innervation of L3 and L4, and receive thalamic input from the ventral posteromedial nucleus and specifically target L4 neurons, avoiding L5 pyramidal cells. L5 Non-martinotti Sst cells tend to show a higher input resistance and seem to be less stuttering." - "A hematopoietic cell that express ROR gamma t and IL-7R alpha in the absence of lineage markers (e.g. CD3, CD19, B220, CD11c, Gr-1), with the functional ability to interact with mesenchymal cells through lymphotoxin and tumor necrosis factor. Lymphoid tissue-inducer cells are key to the development of lymph nodes and Peyer’s patches." "KUPO:0001014" "A basal cell in the respiratory tract." "KUPO:0001137" @@ -542,6 +557,7 @@ "A cell type that varies from squamous to columnar, depending on their activity with microvillus directed luminally. This cell produces and secretes thyroid hormones." "FMA:68782 BTO:0003736 CALOHA:TS-1285" "A synovial cell type that resembles fibroblasts, has abundant granular endoplasmic reticulum but contains fewer vacuoles and vesicles. This cell type secretes glycoproteins and hyaluronic acid." "FMA:66788" + "A pyramidal neuron which lacks a clear tuft formation but extends to large radial distances." "OBSOLETE: The reproductive structure of bacteria, fungi and cryptograms." "A megakaryocyte erythroid progenitor cell that is Kit-positive and is Sca1-negative, CD34-negative, CD90-negative, IL7r-alpha-negative and Fcgr II/III-low." "Cumulus cell is a specialized granulosa cell that surrounds and nourishes the oocyte. This cell-type surrounds the fully-grown oocyte to form a cumulus-oocyte complex (abbr. COC). The terms cumulus oophorus cells, cumulus granulosa cells, cumulus oophorous granulosa cells, granulosa-cumulus cells are used to make a distinction between this cell and the other functionally different subpopulation of granulosa cells at the wall of the Graafian follicle." "BTO:0002236" @@ -653,8 +669,8 @@ "A transitional myocyte that is part of the middle internodal tract." "FMA:263162" "An epithelial cell with high nuclear and cytoplasmic electron-density. This cell type is found in the deeper portions of the cortex but is more abundant in the medulla of the thymus." "FMA:72212" - "Pyramidal neurons have a pyramid-shaped soma with the apex and an apical dendrite pointed toward the pial surface and other dendrites and an axon emerging from the base. The axons may have local collaterals but also project outside their region. Pyramidal neurons are found in the cerebral cortex, the hippocampus, and the amygdala." "FMA:86775 NIFSTD:sao862606388 BTO:0003102 FMA:67310" + "A type of foam cell derived from a smooth muscle cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." "A central nervous system macrophage found at the interface between the blood and the cerebrospinal fluid in the brain. This cell expresses scavenger receptors." "A precursor in the monocytic series, being a cell intermediate in development between the monoblast and monocyte. This cell is CD11b-positive and has fine azurophil granules." "FMA:83551 BTO:0004657" @@ -678,6 +694,7 @@ "A cell type that encapsulates the capillaries and venules in the kidney. This cell secretes mesangial matrix that provides the structural support for the capillaries." "BTO:0000853 FMA:70972 CALOHA:TS-0617" "A basophil precursor in the granulocytic series, being a cell intermediate in development between a basophilic myelocyte and a band form basophil. The nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare. Markers are CD11b-positive, CD15-positive, CD16-positive, CD24-positive, CD33-positive, and CD13-positive." "FMA:84198" "An epithelial cell that has its apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen." "FMA:62122 BTO:0000398" + "Pyramidal neurons have a pyramid-shaped soma with a single axon, a large apical dendrite and multiple basal dendrites. The apex and an apical dendrite typically point toward the pial surface and other dendrites and an axon emerging from the base. The axons may have local collaterals but also project outside their region. Pyramidal neurons are found in the cerebral cortex, the hippocampus, and the amygdala." "FMA:86775 NIFSTD:sao862606388 BTO:0003102 FMA:67310" "A mature natural killer cell that has the phenotype CD56-low, CD16-positive and which is capable of cytotoxicity and cytokine production." "Skeletogenic cell that has the potential to transform into an osteoblast, and develops from neural crest or mesodermal cells." "A transitional myocyte that is part of the atrial branch of anterior internodal tract." "FMA:263156" @@ -689,6 +706,7 @@ "An epithelial cell that is part of the amnion." "An epithelial cell of stratum corneum of esophageal epithelium." "FMA:70733" "Skeletogenic cell that has the potential to develop into an ameloblast. Located in the inner enamel epithelium, these cells elongate, their nuclei shift distally (away from the dental papilla), and their cytoplasm becomes filled with organelles needed for synthesis and secretion of enamel proteins." + "The dead keratin-filled squamous cell of the stratum corneum. This cell type lacks a nucleus." "BTO:0001943 FMA:68650" "A Feyrter cell that is part of the epithelium of trachea." "FMA:263184" @@ -738,6 +756,7 @@ "A preadipocyte that is part of subcutaneous tissue." "A cell in the zona fasciculata that produce glucocorticoids, e.g cortisol." "FMA:69547" + "A giant pyramidal neuron with a soma in layer Vb of the primary motor cortex that sends its axons down the spinal cord via the corticospinal tract, either synapsing directly with alpha motor neurons, or targeting interneurons in the spinal cord. In humans, Betz cells are the largest known in the central nervous system." "A group 2 innate lymphoid cell in the human with the phenotype CD25-positive, CD127-positive, CD161-positive, and GATA-3-positive." "A renal filtration cell is a specialized cell of the renal system that filter fluids by charge, size or both." @@ -748,6 +767,7 @@ "A Paneth cell that is part of the epithelium proper of small intestine." "FMA:263106" "Endothelial cells forming the walls of the capillaries within the cerebral cortex." "CALOHA:TS-2372" "A muscle cell that is part of the middle internodal tract." "FMA:223279" + "A pyramidal neuron which lacks a tuft formation but extends small radial distances forming a star-like shape." "A cultured cell that is freshly isolated from a organismal source, or derives in culture from such a cell prior to the culture being passaged." "BTO:0002290" "Any native cell that is part of a hypothalamus." "An innate lymphoid cell that is capable of producing T-helper 2-cell associated cytokines upon stimulation." @@ -785,6 +805,7 @@ "A mechanoreceptor in the organ of Corti. In mammals the outer hair cells are arranged in three rows which are further from the modiolus than the single row of inner hair cells. The motile properties of the outer hair cells may contribute actively to tuning the sensitivity and frequency selectivity of the cochlea." "FMA:62366 BTO:0003666" "A mammary epithelial cell that occurs in the lumen of the ductal and alveoli structure in the breast." "FMA:73280" "An extracellular matrix secreting cell that secretes eggshell." + "A double negative thymocyte that is CD3-positive, CD4-negative, CD8-negative, that that are present in the periphery in very low numbers and predominantly produce INF-gamma, TNF-alpha, and a low amount of TGF-beta, but not IL-2, IL-4, IL-10 or IL-13 upon activation." "FBbt:00001691" @@ -848,6 +869,7 @@ "Characteristic early embryonic cell with a bottle or flask shape that is first to migrate inwards at the blastopore during gastrulation in amphibians." "A myoepithelial cell that is part of the main lactiferous duct." "FMA:74499" "An endothelial cell that is part of the thoracic endothelium." + "a L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex that has inverted pyramidal morphology." "Fibroblast from foreskin." "CALOHA:TS-0384" "Mesenchymal derived lymphatic progenitor cells that give rise to the superficial lymphatics." "The various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the stomach." @@ -865,6 +887,7 @@ "A peptide hormone secreting cell that secretes vasopressin stimulating hormone" + "A glutamatergic neuron, with a soma found in the deeper portion of L5, that has long-range axonal projections including deep subcortical targets outside of the telencephalon and, in some cases, the spinal cord. While the L5 ET neuron projections are not limited to ET targets, they are clearly differentiated from the neuron subclasses whose projections are constrained to intratelencephalic (IT) targets. L5 ET neurons are generally the largest excitatory cortical neurons, typically having a thick apical dendrite with a prominent dendritic tuft in layer 1 and displaying burst-firing physiological characteristics." "A CD11b-positive dendritic cell located in the serosal portion of the small intestine epithelium. This cell type is CD45-positive, MHC-II-positive, CD11c-low, CD103-negative." "A sperm cell that is cabaple of motion (motility)." "An epithelial cell of the cervix." @@ -914,11 +937,13 @@ "A parathyroid chief cell that is not actively secreting hormone. Contains small Golgi complexes with only a few grouped vesicles and membrane-bound secretory granules; glycogen and many lipofuscin granules abound but sacs of granular endoplasmic reticulum are rare and dispersed. In normal humans, inactive chief cells out number active chief cells in a ratio of 3-5:1." "An epithelial cell of the esophageal gland proper." "FMA:256141" + "A group 3 innate lymphoid cell that express ROR gamma t and IL-7R alpha in the absence of lineage markers (e.g. CD3, CD19, B220, CD11c, Gr-1), with the functional ability to interact with mesenchymal cells through lymphotoxin and tumor necrosis factor. Lymphoid tissue-inducer cells are key to the development of lymph nodes and Peyer’s patches." "A NK1.1-positive T cell that is Ly49Cl-negative." "A female germ cell that has entered meiosis." "WBbt:0006797 FMA:18644 FBbt:00004886 BTO:0000964 CALOHA:TS-0711" "KUPO:0001123" "Sympathetic neurons are part of the sympathetic nervous system and are primarily adrenergic producing the neurotransmitter noradrenalin along with other neuropeptides." "An OFF-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the outer half of the inner plexiform layer. The cell body of these cells is in the middle of the inner plexiform layer. The dendritic tree is stout and the axon terminates in sublamina 1. The axonal terminal is wide and has only a few varicosities." + "An intestinal tuft cell that is a part of a vermiform appendix." "A B cell of distinct lineage and surface marker expression. B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas. These cells are CD43-positive." "A supporting cell for the developing female gamete in the ovary of mammals. They develop from the coelomic epithelial cells of the gonadal ridge. Granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle. The major functions of granulosa cells include the production of steroids and LH receptors." "FMA:18718 CALOHA:TS-0729 BTO:0000542" "A myoblast that detemines the properties (size, shape and attachment to the epidermis) of a `somatic muscle myotube` (CL:0008003) . It develops into a somatic muscle myotube via fusion with `fusion component myoblasts` (CL:0000621)." @@ -954,6 +979,7 @@ "Any vein endothelial cell that is part of a hindlimb stylopod." "An endothelial cell that is part of the venule." "FMA:67762" + "An interneuron that selectively innervates the axon initial segment of pyramidal cells. Their local axonal clusters are formed by high-frequency branching at shallow angles, often ramifying around, above or below their somata with a high bouton density. The characteristic terminal portions of the axon form short vertical rows of boutons, resembling a chandelier. Chandelier cells can be multipolar or bitufted." "ILX:0777213" "A bipolar neuron found in the retina that is synapsed by rod photoreceptor cells. These neurons have axons that arborize and synapse to targets in inner plexiform layers 4 and 5 and depolarize in response to light." "A cell type that is the first of the maturation stages of the granulocytic leukocytes normally found in the bone marrow. Granules are seen in the cytoplasm. The nuclear material of the myelocyte is denser than that of the myeloblast but lacks a definable membrane. The cell is flat and contains increasing numbers of granules as maturation progresses." "BTO:0000734 FMA:83525" "An endothelial cell that lines the oral cavitiy including the mucosa of the gums, the palate, the lip, and the cheek." @@ -1006,6 +1032,7 @@ "Connective tissue cells of the endometrium, these cells are fibroblastic in appearance. During decidualization they tranform into decidual (stromal) cells, swellling up and adopt an epithelial cell-like appearance due to the accumulation of glycogen and lipid droplets." "FMA:86490 CALOHA:TS-1266" "A mature alpha-beta T cell of a distinct lineage that bears natural killer markers and a T cell receptor specific for a limited set of ligands. NK T cells have activation and regulatory roles particularly early in an immune response." "An endocrine cell that has the specialized function to produce and secrete hormones in response to neuronal signals." "FMA:83810 BTO:0002691" + "A basket cell with axonal arbors composed of frequent, short, curvy axonal branches that tend to be near their somata and within the same layer." "A mesenchymal stem cell of adipose tissue." "An epithelial cell that is part of the epithelium of a tracheal tube in an open tracheal system, such as that found in insects." "Any fibroblast that is part of a embryo." @@ -1022,13 +1049,13 @@ "A transitional myocyte that is part of the internodal tract." "FMA:83387" "A CD24-low, CD44-positive, DX5-high, NK1.1-negative NK T cell." "A transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen. This cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative, and CD93-positive. This cell type has also been described as IgM-high, CD19-positive, B220-positive, AA4-positive, and CD23-negative." - "A Vip GABAergic cortical interneuron with bipolar morphology, found in L2/3. L2/3 bipolar Vip Cells have extending axons across all layers (with preferences for layers II/III and Va) and a dendritic tree that is vertically more restricted than deeper layer VIP cells and extend fewer dendrites into the layers outside their home layer (location of soma). L2/3 Bipolar Vip Cells have great variability in firing patterns, though most are continuous adapting. L2/3 Bipolar Vip Cells are more depolarized in their resting state, had less fast rectification, and had smaller after hyperpolarization than deeper Vip cells." "A mesothelial cell that is part of the dura mater." "FMA:256516" "Specialized cardiac myocyte that is subendocardially interspersed with the regular cardiac muscle cell. They are uninucleate cylindrical cells, associated end-to-end in long rows, continue from the node to the atrioventricular bundle; relatively short compared to ordinary myocytes but are nearly twice their diameter." "FMA:14146 BTO:0001032" "A small cell formed by the second meiotic division of oocytes. In mammals, the second polar body may fail to form unless the ovum has been penetrated by a sperm cell." "FMA:18651 EMAPA:16045 EHDAA2:0001820 EMAPA:16034" "Obsolete. Use PO:0000245 from Plant Ontology instead. In monosporic and bisporic megasporogenesis: the megaspore(s) that do not participate in megagametogenesis." "A precursor B cell is CD45R-positive, CD43-positive, CD24-positive, and BP-positive. Intracellularly expression of surrogate light chain, Rag1 and Rag2, TdT, occurs while there is no expression of mu heavy chain." "A glandular epithelial cell of the large intestine." "FMA:87194" + "An interneuron that has spider-like appearance with a small round soma, a large number (7-10) of short, smooth, or slightly beaded primary dendrites that give rise to only a few secondary branches, and a branched axon that establishes a dense axonal mesh with thin shafts." "An ionocyte that is part of the lung epithelium. The cells from this type are major sources of the CFTR protein in human and mice." "A mesenchymal stem cell of liver." "An epithelial cell of the exocrine pancreas." "FMA:70986" @@ -1111,7 +1138,6 @@ "A cell with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue. They are unrelated to the dendritic cell associated with T cells. Follicular dendritic cells have Fc receptors and C3b receptors, but unlike other dendritic cells, they do not process or present antigen in a way that allows recognition by T cells. Instead, they hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response." "FMA:83037 BTO:0004267" - "A Lamp 5 GABAergic cortical interneuron with neurogliaform morphology located in L5,6. L5,6 NGC Lamp5 have deep afterhyperpolarization (AHP) but narrow action potentials (APs). Unlike other deep neurogliaform cells (which are caudal ganglionic eminence (CGE) derived), L5,6 NGC Lamp5 cells are medial ganglionic eminence (MGE)-derived" "A precursor B cell that is AA4-positive, IgM-negative, CD19-positive, CD43-positive and HSA-positive." "Obsolete. Use PO:0030007 from Plant Ontology instead. The apical cell is the upper cell formed after the first division of a plant zygote." @@ -1122,6 +1148,7 @@ "Any endothelial cell of artery that is part of a umbilical cord." "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons." "FMA:54536 BTO:0002606 CALOHA:TS-0415" "A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." "VHOG:0001535 CALOHA:TS-0583 FMA:62863 BTO:0000775" + "An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 2/3." "Cytoplasm that exhibits a characteristic staining and color, pale-pink, with Wright-Giemsa stain." "Glial cell of cerebral cortex." "CALOHA:TS-1256" "A gut-associated lymphoid tissue macrophage found in lamina propria of the gut." @@ -1138,6 +1165,7 @@ "A supportive cell that has characteristics of glial cell. Processes of this cell envelope the junctions between glomus cells and nerve endings." "FMA:84188" "A B220-low CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-low, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery." "A hematopoietic stem cell that has plasma membrane part Kit-positive, SCA-1-positive, CD150-positive and CD34-negative." + "A corticothalamic-projecting glutamatergic neuron that is located in L6 and lower L5 of the primary motor cortex, with a pyramidal morphology and mostly untufted apical dendrites terminating in midcortical layers. CT VAL/VM cells have a near tonic firing pattern and are distinguished from L6 IT neurons by a lower inter-spike interval adaptation index." "Any neuromast support cell that is part of a anterior lateral line." "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive." "Obsolete. Use PO:0000431 from Plant Ontology instead. A diploid (2n) cell that undergoes meiosis and produces four haploid (1n) megaspores; also called megaspore mother cell." @@ -1172,6 +1200,7 @@ "KUPO:0001039" "A respiratory stem cell found at the junction of the terminal (conductive) bronchiole and the respiratory bronchiole, which gives rise to alveolar cell types and club cells in response to lung injury." "A eosinophil precursor in the granulocytic series, being a cell intermediate in development between a promyelocyte and a metamyelocyte;in this stage, production of primary granules is complete and eosinophil-specific granules has started. No nucleolus is present. These cells are integrin alpha-M-positive, CD13-positive, CD15-positive, CD16-negative, CD24-positive, and CD33-positive." "FMA:83542 BTO:0003454" + "A mouse GABAergic cell located in the cerebral cortex that expresses meis2." "A motile sperm cell that contain no F-actin, and their motility is powered by a dynamic filament system." "Infrequent type of columnar epithelial cell. This cell is characterized by the presence of a tuft of blunt, squat microvilli (approximately 120-140/cell) on the cell surface. The microvilli contain filaments that stretch into the underlying cytoplasm. They have a distinctive pear shape with a wide base and a narrow microvillous apex. Function not known." "A progenitor cell committed to the basophil lineage. This cell lacks hematopoietic lineage markers (lin-negative) and is CD34-positive, T1/ST2-low, CD117-negative, and FceRIa-high. This cell also expresses Gata-1, Gata-2 and C/EBPa." @@ -1204,8 +1233,10 @@ "Any microvascular endothelial cell that is part of a brain." "A CD4-positive, alpha beta memory T cell with the phenotype CD45RA-positive, CD45RO-negative, and CCR7-negative." "A chromaffin cell that is part of the left ovary." "FMA:74321" + "An extratelencephalic-projecting glutamatergic neuron located in layer 5b of the primary motor cortex that projects to the medulla. MY ET cells are large, big-tufted cells with the apical dendrite often bifurcating close to the soma, suggesting they are corticospinal cells. MY ET cells have bigger hyperpolarization sag, lower input resistance, and smaller AP width, compared to L5 IT neurons." "FBbt:00004873" "A dendritic cell of the myeloid lineage." "BTO:0004721" + "An intratelencephalic-projecting glutamatergic neuron with a soma found in L5 of the primary motor cortex." "ILX:0770157" "A cardiac myocyte that is an excitable cells in the myocardium, specifically in the conducting system of heart." "FMA:67968" "A cell located in the outermost proliferative zone of the external germinal layer that can differentiate into astroglial cells and granule cells. This cell type is glial fibrillary acidic protein-positive and NK1-positive." @@ -1254,10 +1285,12 @@ "An elicited macrophage that is recruited into the tissues in response to injury and infection as part of an inflammatory response, expresses high levels of pro-inflammatory cytokines, ROS and NO, and shows potent microbicidal activity." "An enterocyte that is part of the epithelium proper of duodenum." "FMA:263098" + "A corticothalamic-projecting neuron with a soma found in cortical layer 6." "A lymphocyte of B lineage that is CD19-positive." "Any striated muscle cell that is part of a skeletal muscle tissue of pectoralis major." "A rapidly cycling mature B cell that has distinct phenotypic characteristics and is involved in T-dependent immune responses and located typically in the germinal centers of lymph nodes. This cell type expresses Ly77 after activation." + "A motor neuron that is located in the cervical region of the spinal cord and selectively innervates the sternocleidmastoid or trapezius muscle. Unlike other motor neurons, they extend axons dorsally along lateral margins of the spinal cord." "A paracrine cell is a secretory cell that secretes an agonist into intercellular spaces in which it diffuses to a target cell other than that which produced it." "An epithelial cell that is part of the lacrimal duct." "FMA:70559" @@ -1295,6 +1328,7 @@ "A thick walled, sexual, resting spore formed by Zygomycetes; sometimes refers to the spore and the multi-layered cell wall that encloses the spore, the zygosporangium." "FAO:0000040" "Goblet cells reside throughout the length of the small and large intestine and are responsible for the production and maintenance of the protective mucus blanket by synthesizing and secreting high-molecular-weight glycoproteins known as mucins. Human intestinal goblet cells secrete the MUC2 mucin, as well as a number of typical mucus components: CLCA1, FCGBP, AGR2, ZG16, and TFF3." "A B cell that is CD19-positive." + "A basket cell that is large, and typically ascends to give rise to many long horizontally and vertically projecting axon collaterals that traverse neighboring columns and can extend through all cortical layers." "A transitional myocyte that is part of the septal division of left branch of atrioventricular bundle." "FMA:263168" "A stromal cell of the pancreas." "A myeloid dendritic cell with the phenotype HLA-DRA-positive." @@ -1304,6 +1338,7 @@ "A mesothelial cell that is part of the pleura." "FMA:86737" "KUPO:0001117" "A neuron that uses acetylcholine as a vesicular neurotransmitter." "WBbt:0006840 FMA:84796 BTO:0004902" + "A transit amplifying cell that is part of a crypt of Lieberkuhn of large intestine." "A natural killer cell that is developmentally immature, has the phenotype CD34-negative, CD56-negative, CD117-positive, CD122-positive,and CD161-positive." "KUPO:0001046" "A cell with delicate radiating processes known as desmosomes that form intercellular bridges between other cells of this type. This cell type forms the stratum spinosum (prickle cell layer). A function of this cell is to generate keratin." "FMA:69059" @@ -1349,8 +1384,8 @@ "Fat cells with light coloration and few mitochondria. They contain a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole." "CALOHA:TS-1119 FMA:83434" "An orthochromatophilic erythroblast that is ter119-high, CD71-low, and Kit-negative." - "A Lamp5 GABAergic cortical interneuron that is strongly labelled for α7 nAChRs. These cells are located in L1 and have multipolar dendrites with vertically descending axonal collaterals that project deep into the column, usually branching and terminating in L5A. Unlike typical Lamp5 electrophysiology, they have Vip- and Sst-like firing properties, with active depolarizing hump at near-threshold membrane potentials, and larger hyperpolarization sag, stronger burst, and rebound firing." "KUPO:0001073" + "A Lamp 5 GABAergic cortical interneuron with neurogliaform morphology with a soma found in L5,6. L5,6 NGC Lamp5 have deep afterhyperpolarization (AHP) but narrow action potentials (APs). Unlike other deep neurogliaform cells (which are caudal ganglionic eminence (CGE) derived), L5,6 NGC Lamp5 cells are medial ganglionic eminence (MGE)-derived" "KUPO:0001053" "A cell pyramidal in shape, with their broad ends facing and forming the greater extent of the lining of the main lumen. Secretes glycoproteins associated with mucus." "FMA:70659" "A cell, usually of bacteria or yeast, which has partially lost its cell wall." @@ -1366,15 +1401,19 @@ "An epidermal cell that is part of the germinal matrix." "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. This cell has the widest dendritic field and the widest axon terminal of all retinal bipolar cells. The axon terminal is delicate and stratified through sublaminae 4 and 5 of the inner plexiform layer." "A neurecto-epithelial cell found in the arachnoid villi of dura mater. This cell type facilitates flow of cerebrospinal fluid into the blood." "FMA:86588" + "A basket cell which has simpler dendritic arbors (compared to small or large basket cells), and an axonal plexus of intermediate density, composed of a few long, smooth axonal branches." "A large nucleated basophilic erythrocyte found in mammalian embryos. This cell type arises from the blood islands of yolk sacs and expresses different types of hemoglobins (beta-H1, gamma-1 and zeta) than adult erythrocytes. Considered a type of erythroblast as this cell type can enucleate in circulation." "A non-terminally differentiated cell that is capable of developing into a muscle cell." "KUPO:0001025" "Any of the immature forms of a basophil, in which basophilic specific granules are present but other phenotypic features of the mature form may be lacking." "A fibroblasts found in interstitial spaces in the pulmonary tract. Greater numbers of these cells are found in idiopathic pulmonary fibrosis." "FMA:84467" "The motor neurons of vertebrates that directly innervate skeletal muscles. They receive input from upper motor neurons." "FMA:84632" + "Basket cells are inhibitory GABAergic interneurons of the brain. In general, dendrites of basket cells are free branching and contain smooth spines. Axons are highly branched. The branched axonal arborizations give rise to basket-like structures that surround the soma of the target cell. Basket cells form axo-somatic synapses, meaning their synapses target somas of other cells." "An endocrine cell that secretes vasoactive intestinal peptide." + "A pyramidal neuron which has a distinctive tuft formation, distal from the soma." "KUPO:0001098" "A cell of the outer of the three germ layers of the embryo." "FMA:72549" + "A T cell that is located in a vermiform appendix." "Any of the immature forms of an eosinophil, in which eosinophilic specific granules are present but other phenotypic features of the mature form may be lacking." "A somatic stem cell that is part of the epidermis." "FMA:70541" "A macrophage which is resident in the lamina propria of the small intestine." @@ -1390,6 +1429,7 @@ "Cell committed to natural killer cell lineage that has the phenotype CD122-positive, CD34-positive, and CD117-positive. This cell type lacks expression of natural killer receptor proteins." "A Be cell that facilitates development of T-helper 2 (Th2) phenotype T cells, and secretes high levels of interleukin-2, interleukin-10, interleukin-4, and interleukin-6." "A short lived plasma cell that secretes IgA. These cells may be found in the bone marrow as well as in the mucosal immune system." + "A cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system." "KUPO:0001071" "The myoendocrine cellis a specialized myocyte localized mainly in the right and left atrial appendages, and also scattered within other areas of the atria and along the conductive system in the ventricular septum. The most conspicuous feature distinguishing myoendocrine cells from other atrial myoctyes is the presence of membane-bounded secretory granules (these granules contain precursor of cardiodilatins or atrial natriuretic polypeptides)." "FMA:67111" @@ -1471,6 +1511,7 @@ "Obsolete. Use PO:0000084 from Plant Ontology instead. Male gamete, part of male germ unit." "A venule endothelial cell that is cubodial, expresses leukocyte-specific receptors, and allows for passage of lymphocytes into bloodstream." "FMA:67759" "A cell that originates in the neural crest, that has certain cytochemical and ultrastructural characteristics and is found scattered throughout the body; types include melanocytes, the cells of the chromaffin system, and cells in the hypothalamus, hypophysis, thyroid, parathyroids, lungs, gastrointestinal tract, and pancreas. This cell type concentrates the amino acid precursors of certain amines and decarboxylate them, forming amines that function as regulators and neurotransmitters. This cell type produces substances such as epinephrine, norepinephrine, dopamine, serotonin, enkephalin, somatostatin, neurotensin, and substance P, the actions of which may affect contiguous cells, nearby groups of cells, or distant cells, thus functioning as local or systemic hormones. The name is an acronym for amine precursor uptake and decarboxylation cell." "FMA:83114 BTO:0003866" + "A Sst GABAergic cortical interneuron with a soma found in lower L5 with mostly local axonal arborization but with some sparse ascending axons. L5 non-Martinotti Sst cells show somatic localization and local axon plexus in L5b and L5b/6 and substantial innervation of L3 and L4, and receive thalamic input from the ventral posteromedial nucleus and specifically target L4 neurons, avoiding L5 pyramidal cells. L5 non-Martinotti Sst cells tend to show a higher input resistance and seem to be less stuttering." "A motor neuron that is generated only on limb levels and send axons into the limb mesenchyme." "An enterocyte that is part of the epithelium of intestinal villus." "FMA:263088" "A circular smooth muscle cell of the iris, innervated by the ciliary nerves (parasympathetic), and acting to contract the pupil. This muscle cell derives from neuroectoderm. This smooth muscle cell results from transformation of epithelial cells to smooth muscle cells." "FMA:70611" @@ -1481,8 +1522,10 @@ "A macrophage located in adipose tissue that is CD45-positive, CD11c-positive, and SIRPa-positive." "A supporting cell of the vestibular epithelium." "FMA:75607" "A spore formed from bacteria in the order Actinomycetales." + "A GABAergic cortical interneuron that expresses CCK. L5/6 CCK cells have soma found mainly in L5 and L6 and have large axonal arborization." "An epithelial cell that is part_of a alveolus of lung." "A cell found within the dental pulp." "CALOHA:TS-0195 FMA:87170 BTO:0000339" + "A Pvalb GABAergic cortical interneuron that is recognizable by the straight terminal axonal 'cartridges' of vertically oriented strings of synaptic boutons. Chandelier PV cells have soma found in in upper L2/3, with some in deep L5. Chandelier PV cells exhibit fast-spiking but lower firing rate compared to basket cells, and have practically absent hyperpolarization sag. Chandelier PV cells' boutons target exclusively the axon initial segment (AIS) of pyramidal cells, with a single cell innervating hundreds of pyramidal cells in a clustered manner." "ILX:0107356" "A CD4-positive, alpha-beta T cell that is found in the columnar epithelium of the gastrointestinal tract." "Any photoreceptor cell that is part of a compound eye." "A cell present in the developing CNS. Functions as both a precursor cell and as a scaffold to support neuronal migration." @@ -1518,6 +1561,7 @@ "Cell that is part of the vagal neural crest population. The vagal neural crest arises from the axial level of somites 1-7 and has been described as a hybrid between the head and the trunk populations." "A cell that is specialized to store a particular substance(s), which is(are) later released from the store for a particular purpose." + "A Martinotti neuron that has axons that form a fan-like plexus." "A cell that makes up the loose connective tissue of the ovary." "FMA:18709" "A myoepithelial cell that is part of the tertiary lactiferous duct." "FMA:74502" "A fast muscle fiber cell that stores energy in the form of glycogen and creatine phosphate." "FMA:84414 BTO:0001813" @@ -1631,6 +1675,7 @@ "A densely staining taste receptor cell that contains many dense vacuoles in their apical regions which project into the apical space and bear microvilli. This cell type serves as a supporting cell by surrounding and isolating the other cell types from each other; secrete a dense amorphous material that surrounds the microvilli in the taste pore. This cell type expresses a glial glutumate transporter, GLAST." "FMA:62356" "A type of cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." "FMA:83586 BTO:0003872" + "A Sst GABAergic cortical interneuron with a soma found in lower L2/3 and upper 5, L4 Sst cells have martinotti morphology with ascending axons but denser local axons and sparser ‘fanning-out’ projections to L1. L4 Sst cells have smaller membrane time constant to calb2 (L2/3/5 Fan Martinotti Cell) and non-zero afterdepolarization (ADP)." "Any fibroblast that is part of a gallbladder." "A T-helper cell that is characterized by secreting interleukin 9 and responding to helminth infections. This cell-type can derives from Th2 cells in the presence of TGF-beta and IL-4. Th2 cytokine production is surpressed." "An epithelial cell that is part_of a umbilical artery." @@ -1650,6 +1695,7 @@ "A segmented neutrophilic cell of the bone marrow reserve pool that expresses CD11b (integrin alpha-M) and high levels of CD16 (low affinity immunoglobulin gamma Fc region receptor III) on its cell surface." "An CD24-positive CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-positive, CD38-negative, and IgG-negative." "A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers." "FMA:83504 CALOHA:TS-0289 BTO:0001571" + "A progenitor cell with hepatic and biliary lineage potential, identified in mouse and human, and anatomically restricted to the ductal plate of fetal liver." "A stem cell that can give rise to cell types of the body other than those of the germ-line." "FMA:63368 CALOHA:TS-2086" "A neuron of the ventral spinal cord." "An epithelial cell of the integument (the outer layer of an organism)." "FMA:62411 CALOHA:TS-0283 BTO:0001470" @@ -1679,6 +1725,7 @@ "A neutrophil precursor in the granulocytic series, being a cell intermediate in development between a myelocyte and the band form neutrophil. The protein synthesis seen in earlier stages decreases or stops; the nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare; and the cytoplasm becomes amphophilic like that of a mature granulocyte. This cell type is integrin alpha-M-positive, CD13-negative, CD15-positive, CD16-positive, CD33-positive, CD24-positive, fMLP receptor-negative and has expression of C/EBP-a, C/EBP-e, PU.1 transcription factor, lactotransferrin, myeloperoxidase and neutrophil gelatinase associated lipocalin." "FMA:84197" "A cell occurring in the peripheral part of the vitreous body of the eye that may be responsible for production of hyaluronic acid and collagen." "FMA:70620 BTO:0004271" "KUPO:0001051" + "A plasma cell that is located in a vermiform appendix." "A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs." "BTO:0003104" "A smooth muscle cell that is part of the sigmoid colon." "FMA:17521" "A transitional myocyte that is part of the posterior division of left branch of atrioventricular bundle." "FMA:263178" @@ -1694,6 +1741,7 @@ "A cell with both myofibrils and secretory granules." "A memory B cell with the phenotype IgD-negative and CD27-negative." "A motile sperm cell that contains a slender threadlike microscopic appendage that enables motion." + "A B cell that is located in a vermiform appendix." "A bipolar neuron found in the retina that is synapsed by rod photoreceptor cells but not by cone photoreceptor cells. These neurons depolarize in response to light." "FMA:67750" "A peptide hormone secreting cell pituitary that produces luteinizing hormone." @@ -1735,6 +1783,7 @@ "KUPO:0001024" "Any basket cell that is part of a dentate gyrus of hippocampal formation." + "A type of mesothelial fibroblast that is derived from the neural crest, is localized on blood vessels, and is a key component of the pia and arachnoid membranes surrounding the brain." "ILX:0770143" "A smooth muscle cell that is part of the ascending colon." "FMA:17518" "A mesenchymal cell that is part of a small mass of condensed mesenchyme in the enamel organ; it differentiates into the dentin and dental pulp." "A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." "BTO:0000801 FMA:63261 FMA:83585 CALOHA:TS-0587" @@ -1769,12 +1818,13 @@ "Chondrocyte forming the hyaline cartilage found in joints." "CALOHA:TS-0056" "Obsolete. Use PO:0000244 from Plant Ontology instead. In monosporic and bisporic megasporogenesis: the megaspore(s) that will undergo megagametogenesis." "KUPO:0001036" + "A immature or mature cell in the lineage leading to and including erythrocytes." "CALOHA:TS-0290 FMA:62845 FMA:83516" - "A stellate interneuron having 7-10 dendrites that may branch." "A Purkinje myocyte that is part of the internodal tract." "FMA:83392" "A melanocyte that appears lighter in color." "Any fibroblast that is part of a pericardium." + "An extratelencephalic-projecting glutamatergic neuron located in layer 5b of the primary motor cortex that does not project to the medulla. Non-MY ET cells are large, big-tufted cells with the apical dendrite often bifurcating close to the soma, suggesting they are corticospinal cells. Non-MY ET cells have bigger hyperpolarization sag, lower input resistance, and smaller AP width, compared to L5 IT neurons." "Contractile cells resembling smooth muscle cells that are present in glands, notably the mammary gland, and aid in secretion. This cell has long weaving dendritic processes containing myofilament." "BTO:0002309 FMA:67799 CALOHA:TS-2379" "A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive." "FMA:66781 BTO:0000968 CALOHA:TS-0721" "A stem cell of embryonic origin." "CALOHA:TS-0263 BTO:0001086 FMA:82841" @@ -1864,6 +1914,7 @@ "A group 3 innate lymphoid cell in the human with the phenotype IL-7Ralpha-positive." "A muscle cell that is part of the atrioventricular node." "FMA:67106" "A smooth muscle cell of the coronary artery." + "An intratelencephalic-projecting glutamatergic with a soma located in upper L5 of the primary motor cortex. These cells have thin untufted apical dendrites." "ILX:0770174" "A specialized epithelial cell involved in sensory perception. Restricted to special sense organs of the olfactory, gustatory, and vestibulocochlear receptor systems; contain sensory cells surrounded by supportive, non-receptive cells." "BTO:0004301" "A pre-B cell that is pre-BCR-negative, and the kappa- and lambda- light immunoglobulin light chain-negative, CD43-low, and is BP-1-positive, CD45R-positive and CD25-positive. This cell type is also described as being AA4-positive, IgM-negative, CD19-positive, CD43-low/negative, and HSA-positive." "A CD8-positive, CD4-negative thymocyte that expresses high levels of the alpha-beta T cell receptor and is CD69-positive." @@ -1881,6 +1932,7 @@ "A flattened epithelial cell of mesenchymal origin that lines the serous cavity." "FMA:66773" "A chromaffin cell of the adrenal medulla that produces norepinephrine." "FMA:69321" "An epithelial supporting cell located in the cochlea." "FMA:79796" + "Skeletogenic cell that has the potential to develop into a chondroblast; and arises from neural crest, meseosdermal and notochordal and connective tissue cells." "A tissue-resident macrophage of the reticuloendothelial system found on the luminal surface of the hepatic sinusoids involved in erythrocyte clearance. Markers include F4/80+, CD11b-low, CD68-positive, sialoadhesin-positive, CD163/SRCR-positive. Irregular, with long processes including lamellipodia extending into the sinusoid lumen, have flattened nucleus with cytoplasm containing characteristic invaginations of the plasma membrane (vermiform bodies); lie within the sinusoid lumen attached to the endothelial surface; derived from the bone marrow, form a major part of the body's mononuclear phagocyte system." "BTO:0000685 FMA:14656" "KUPO:0001133" @@ -1888,11 +1940,13 @@ "A promyelocyte that is considerably smaller, with more condensed chromatin, and nucleoli are no longer conspicuous." "FMA:83534" "A renal intercalated cell that secretes base and reabsorbs acid in the coritcal collecting duct to mantain acid/base balance." "A non-terminally differentiated cell that differentiates into a xanthophore." + "A intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layers L2/3-6" "Skeletogenic cell that has the potential to form an odontoblast, deposits predentine, and arises from a cranial neural crest cell." "An epithelial cell found in the basal part of the intestinal glands (crypts of Lieberkuhn) including the appendix. Paneth cells synthesize and secrete lysozyme and cryptdins. Numerous in the deeper parts of the intestinal crypts, particularly in the duodenum, rich in zinc, contain large acidophilic granules, with irregular apical microvilli and prominent membrane-bound vacuoles containing matrix." "FMA:62897 BTO:0000993" "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner half of the inner plexiform layer. These cells depolarize in response to light stimulation of their corresponding photoreceptors." "A columnar chondrocyte that differentiates in the late embryonic growth plate of bone. Columnar chondrocytes vigorously proliferate and form columns in the growth plate." "A naive B cell is a mature B cell that has the phenotype surface IgD-positive, surface IgM-positive, CD20-positive, CD27-negative and that has not yet been activated by antigen in the periphery." + "An interneuron that has Martinotti morphology. These interneurons are scattered throughout various layers of the cerebral cortex, sending their axons up to the cortical layer I where they form axonal arborization." "nifext_55 ILX:0107375" "A T cell that expresses an alpha-beta T cell receptor complex." "Obsolete. Use PO:0000353 from Plant Ontology instead. Cell in exodermis or endodermis that remains thin walled when the associated cells develop thick secondary walls. Has casparian strip in endodermis." @@ -1909,6 +1963,7 @@ "A GABAergic interneuron located in the cerebral cortex that expresses Parvalbumin." "ILX:0770154" "CD4-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative." "A lymphocyte that is part of a Peyer's patch. These cells have a major role in driving the immune response to antigens sampled from the intestinal lumen, and in regulating the formation of follicle-associated epithelium and M cells in Peyer's patches by converting intestitial enterocytes into M cells." + "A glutamatergic motor neuron with a soma in the brainstem or cerebral cortex. They do not synapse directly to muscles but rather to lower motor neurons, which do. They are the main controllers of voluntary movement." "KUPO:0001134" "A germline cell that contributes to the development of the oocyte by transferring cytoplasm directly to oocyte." "FBbt:00004878 BTO:0000953" "Osteoblast that is non-terminally differentiated and located in cellular bone tissue or under the periosteum in acellular bone." "VSAO:0000117" @@ -2002,6 +2057,7 @@ "Any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes." "CALOHA:TS-0688 BTO:0000130 FMA:62860" "Immature CD11c-negative plasmacytoid dendritic cell is a CD11c-negative plasmacytoid dendritic cell is CD80-negative, CD86-low and MHCII-low." "A lower motor neuron that innervates only intrafusal muscle fibers. Unlike the alpha motor neurons, gamma motor neurons do not directly adjust the lengthening or shortening of muscles but function in adjusting the sensitivity of muscle spindles and in keeping muscle spindles taut, thereby allowing the continued firing of alpha neurons." "SAO:143800623 MESH:D009047 FMA:83660" + "A pyramidal neuron which has an apical tree which is oriented parallel to the pia. This is unlike typical pyramidal neurons which have its apical dendrite aligned vertically." "A cell that moves by its own activities." @@ -2035,6 +2091,7 @@ "A fibroblast that is part of the heart." "A group 3 innate lymphoid cell in the human with the phenotype IL-7Ralpha-positive, and NKp44-positive." + "An intratelencephalic-projecting glutamatergic neuron with a soma found in L6 of the primary motor cortex. These cells are short untufted pyramidal cells, which could be stellate or inverted." "ILX:0770158" "A neuroendocrine cell found in the epithelium of the lungs and respiratory tract. This cell type is rounded or elliptical in shape, situated mainly in the basal part of the epithelium; regulates bronchial secretion, smooth muscle contraction, lobular growth, ciliary activity and chemoreception. Cell has an electron-lucent cytoplasm, contains numerous dense-cored vesicles with a clear halo between the core and the limiting membrane." "FMA:14118" "The larger of two types of asexual spores formed by some fungi; usually round or oblong." "FAO:0000038" @@ -2046,9 +2103,9 @@ "A transitional myocyte that is part of the anterior internodal tract." "FMA:263158" "A tissue-resident macrophage found in the mucosa associated lymphoid tissue." "A mucosa-associated lymphoid tissue macrophage found in the nasal and bronchial mucosa-associated lymphoid tissues." - "A splenic white pulp macrophage found in and around the germinal centers of the white pulp of the spleen that participates in phagocytosis of apoptotic B cells from the germinal centers. A marker for a cell of this type is Mertk-positive." "An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm." "FMA:66772 CALOHA:TS-0278 BTO:0001176" + "A mesothelial cell that is located in a vermiform appendix." "An preBRC-positive large pre-B-II cell is a large pre-B-II cell that is pre-B cell receptor-positive, composed of surrogate light chain protein (SL), which is composed of VpreB , Lambda 5/14.1, in complex with immunoglobulin mu heavy chain (IgHmu) on the cell surface." "A peptide hormone secreting cell that secretes endorphin." @@ -2065,6 +2122,8 @@ "Gr1-high monocyte that has a MHC-II receptor complex." "A cell secreting sweat, the fluid excreted by the sweat glands of mammals. It consists of water containing sodium chloride, phosphate, urea, ammonia, and other waste products." "A non-neuronal cell that surrounds the neuronal cell bodies of the ganglia." "FMA:54550" + "A Vip GABAergic cortical interneuron with bipolar morphology, with a soma found in L2/3. L2/3 bipolar Vip Cells have extending axons across all layers (with preferences for layers II/III and Va) and a dendritic tree that is vertically more restricted than deeper layer VIP cells and extend fewer dendrites into the layers outside their home layer (location of soma). L2/3 Bipolar Vip Cells have great variability in firing patterns, though most are continuous adapting. L2/3 Bipolar Vip Cells are more depolarized in their resting state, had less fast rectification, and had smaller after hyperpolarization than deeper Vip cells." + "A GABAergic cortical interneuron that develops from the caudal ganglionic eminence and has migrated to the cerebral cortex." "KUPO:0001070" "A specialized osteoclast associated with the absorption and removal of cementum." "FMA:83027 BTO:0002516" "OBSOLETE: Initial population of prestalk cells that activate the ecmA promoter at the mound stage and that presumably further differentiate into pstA and pstO cells." @@ -2136,8 +2195,11 @@ "A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD4 co-receptor." "Obsolete. Use PO:0000332 from Plant Ontology instead. An epidermal cell with a characteristic convoluted anticlinal cell wall that gives a jigsaw like appearance to the lamina." "A cubodial epithelial cell that is continuous with the lining of intercalated ducts that drain the acinus. This cell type secretes a high pH solution to aid in activation of zymogens, and can differentiate into endocrine and exocrine pancreatic cell types." "FMA:62455" + + "A mesothelial cell that has undergone mesothelial-to-mesenchymal transition (MMT) to become a fibroblast cell." "Obsolete. Consult Plant Ontology. A cell that develops from the ray initial and composes all rays (panels of tissue variable in height and width, formed by the ray initials in the vascular cambium and extending radially in the secondary xylem and secondary phloem) in the secondary vascular tissues." "An endothelial cell that is part of the vein." "KUPO:0001099 FMA:62104" + "A Sst GABAergic cortical interneuron transcriptomically between the Sst and the Pvalb families with a soma found in L2/3. Some L2/3 PV-like SST cells have Martinotti morphology while some have basket cell morphology. L2/3 PV-like SST cells have lower AP width and higher firing rate than typical Sst subclass cells. L2/3 PV-like SST cells have high maximum firing rate variability, with many classified as belonging to the Pvalb subclass on the basis of electrophysiology." "A plasmablast that secretes IgD, and which occur in a small proportion of B cells in the adult." "FBbt:00005147" @@ -2147,6 +2209,7 @@ "A myeloid dendritic cell found in the blood, lymph nodes, tonsil, bone marrow, and spleen that is CD141-positive (BDCA-3), XCR1-positive, and Clec9A-positive. This cell-type can cross-present antigen to CD8-positive T cells and can produce inteferon-beta." "A M cell that is part of the epithelium proper of large intestine." "FMA:263142" + "An intestinal enteroendocrine cell that is located in a vermiform appendix." "Neuron of lateral ventricle." "CALOHA:TS-1261" "KUPO:0001066" "A type I NK T cell that has the phenotype CD4-positive." @@ -2176,10 +2239,12 @@ "Glandular cell of epididymal epithelium." "CALOHA:TS-1276" "KUPO:0001121" "A Boettcher cell is a polyhedral cells on the basilar membrane of the cochlea, and is located beneath Claudius cells. A Boettcher cell is considered a supporting cell for the organ of Corti, and is present only in the lower turn of the cochlea. These cells interweave with each other, and project microvilli into the intercellular space. Because of their structural specialization, a Boettcher cell is believed to play a significant role in the function of the cochlea. They demonstrate high levels of calmodulin, and may be involved in mediating Ca(2+) regulation and ion transport." + "A Martinotti neuron that has axons that form a horizontal ramification, making it T-shaped." "BTO:0003064" "Parasympathetic neurons are part of the parasympathetic nervous sysem and the cell bodies lie in the brain and sacral region of the spinal cord. The neurons are mainly cholinergic." "A cell of a fetus which is suspended in the amniotic fluid. Amniocytes are considered to arise from several tissues including fetal skin, the fetal urinary tract, umbilical cord, and the inner amniotic surface." "BTO:0000066" + "A Sst GABAergic cortical interneuron that has \"fanning-out' Martinotti morphology that is found in layer 2/3/5 of the cerebral cortex. They have local axon arbor and long ascending axons that spreads horizontally and arborizes significantly in L1." "A fat cell that is part of the epicardial fat." "FMA:261293" "A CD24-low, CD44-positive, DX5-low, NK1.1-negative NK T cell." "A transversely striated, synctial muscle cell, formed by the fusion of myoblasts." @@ -2206,7 +2271,6 @@ "An innate lymphoid cell in the human with the phenotype KLRG1-positive that is a precusor for ILC2 cells." "A smooth muscle cell that is part of the rectum." "FMA:17522" "An extremely flattened cell type found on the inner side of the tympanic membrane. The surface of this cell type carries sparse pleomorphic microvilli that are more common near the junctional zones." "FMA:70626" - "A Sst GABAergic cortical interneuron transcriptomically between the Sst and the Pvalb families and found in L2/3. Some L2/3 PV-like SST cells have Martinotti morphology while some have basket cell morphology. L2/3 PV-like SST cells have lower AP width and higher firing rate than typical Sst subclass cells. L2/3 PV-like SST cells have high maximum firing rate variability, with many classified as belonging to the Pvalb subclass on the basis of electrophysiology." "A neoplastic cell that is capable of entering a surrounding tissue" "https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C12917" "Any melanocyte that is part of a prepuce of penis." "Circulating macrophages and tissue macrophages (alveolar macrophages) of lung." "CALOHA:TS-0576" @@ -2257,6 +2321,7 @@ "An epithelial cell that is part of a nephron tubule." "KUPO:0001022 FMA:86785" "A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone." "CALOHA:TS-2096 FMA:63875" + "A Vip GABAergic cortical interneuron that expresses CCK. L5/6 CCK cells have soma found mainly in L5 and L6 and have large axonal arborization." "An epithelial cell of thyroid gland." "FMA:256167" "Neuroendocrine cells that are born in the nasal placode during embryonic development and migrate through the nose and forebrain to the hypothalamus, where they regulate reproduction." "An innate lyphoid cell with an immature phenotype." @@ -2264,6 +2329,7 @@ "A peptide hormone secreting cell that secretes gastrin." "A muscle cell with low content of myoglobin and other oxygen storing proteins. This muscle cell has a white appearance." "FMA:84449" "A taste receptor cell that has a short microvilli, a projecting apical region, a large rounded nucleus, and expresses taste chemoreceptors thus making them the transducing cell for taste qualities." "FMA:62381" + "An enteroendorcine cell found in the ileum and jejunum that produces neurotensin." "FMA:62943" "WBbt:0006829" "Any blood vessel endothelial cell that is part of a dermis." @@ -2299,6 +2365,7 @@ "A nodal myocyte that is part of the sinoatrial node." "FMA:83383" "Any cell participating in the inflammatory response to a foreign substance, e.g. neutrophil, macrophage." "http://en.wikipedia.org/wiki/Inflammatory_response GOC:pr" "Any hematopoietic cell that is a precursor of some other hematopoietic cell type." + "A Vip GABAergic cortical interneuron with a soma found in L5. L5 Vip cells have mostly local morphology with some deep-projecting axons. They show only moderate resistance, comparable to that of Sst subclass and unlike typical Vip subclass cells that tend to show high input resistance. L5 Vip cells show particularly low resting membrane potential." "Any neuron that is part of a central nervous system." "A conventional dendritic cell that expresses CD11b (ITGAM)." "A cell whose primary function is intermediary metabolism." @@ -2308,6 +2375,7 @@ "Any fibroblast that is part of a cardiac ventricle." "A fat cell that is beige in color, thermogenic, and which differentiates in white fat tissue from a Myf5-negative progenitor." + "A type of mouse mesothelial fibroblast that is derived from the neural crest, is localized on blood vessels, and is a key component of the pia and arachnoid membranes surrounding the brain." "A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration." "Any endothelial cell that is part of a spleen." "CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive, CXCR3-negative, CCR6-positive, and capable of producing IL-17." @@ -2316,7 +2384,6 @@ "A mature NK T cell that secretes interferon-gamma and enhances Th1 immune responses." "A lineage marker-negative, CD34-positive, CD38-positive, IL3r-alpha-positive, IL5r-alpha-positive, and CD45RA-negative eosinophil progenitor cell." - "A Pvalb GABAergic cortical interneuron that is recognizable by the straight terminal axonal 'cartridges' of vertically oriented strings of synaptic boutons. Chandelier PV cells are mostly found in upper L2/3, with some in deep L5. Chandelier PV cells exhibit fast-spiking but lower firing rate compared to basket cells, and have practically absent hyperpolarization sag. Chandelier PV cells' boutons target exclusively the axon initial segment (AIS) of pyramidal cells, with a single cell innervating hundreds of pyramidal cells in a clustered manner." "ILX:0107356" "A myofibroblast that lies in the connective tissue of the spinal cord that has a distinctly lamellar arrangement." "Mature T cell not yet exposed to antigen with the phenotype CCR7-positive, CD45RA-positive, and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low." "A thymocyte that has the phenotype CD4-negative, CD8-positive, CD44-negative, CD25-negative, and pre-TCR-positive." @@ -2327,7 +2394,6 @@ "Mural cells are pericytes and the vascular smooth muscle cells (vSMCs) of the microcirculation." "A primitive erythrocyte that has undergone enucleation. This cell type is 3-6 fold bigger than the fetal derived erythrocytes that they co-circulate with during fetal development. Expresses epsilon-gamma hemoglobin chains." "A CD8-positive, alpha-beta T cell that is capable of killing target cells in an antigen specific manner with the phenotype perforin-positive and granzyme B-positive." "FMA:70573 CALOHA:TS-0190" - "A Sst GABAergic cortical interneuron that has \"Fanning-out' Martinotti morphology with local axon arbor and long ascending axons that spreads horizontally and arborizes significantly in L1. They have an adapting firing pattern and non-zero afterdepolarization (ADP)." "A melanocyte that is part of the eyelid." "FMA:59175" "A small cell formed by the first meiotic division of oocytes." "VHOG:0000464 EMAPA:16032 EHDAA2:0000541 FMA:18650" @@ -2358,6 +2424,7 @@ "A plasmablast that secretes IgG." "A CD4-negative, CD8-negative, alpha-beta intraepithelial T cell that is found in the columnar epithelium of the gastrointestinal tract." "A cell that secretes insulin and is located towards the center of the islets of Langerhans." "EV:0200009 ncithesaurus:Beta_Cell MA:0002419 BTO:0000783 FMA:70586" + "a L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex that has stellate pyramidal morphology." "An epithelial cell of the prostate." "FMA:66817 FMA:256163" "A peptide hormone cell that secretes prolactin." @@ -2406,10 +2473,10 @@ "A giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm." "CALOHA:TS-0611 FMA:83555 BTO:0000843" "Ghrelin secreting cells found in the exocrine pancreas." "A megakaryocyte erythroid progenitor cell is CD34-positive, CD38-positive and is IL3-receptor alpha-negative and CD45RA-negative." + "An ON-bipolar neuron found in the retina and having connections with cone photoreceptors cells and neurons in the inner half of the inner plexiform layer. The axon terminal is restricted to sublamina 3 of the inner plexiform layer. It is narrowly stratified and branched. The dendritic tree has many delicate branches." "An immature or mature cell of the first erythroid lineage to arise during embryonic development." - "A Vip GABAergic cortical interneuron that expresses CCK. L5/6 CCK cells are found mainly in L5 and L6 and have large axonal arborization." "A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring." "A smooth muscle of the pulmonary artery." "BTO:0003336" "A hematopoietic stem cell capable of rapid replenishment of myeloerythroid progenitors and limited self renewal capability. This cell is Kit-positive, Sca1-positive, CD34-positive, CD150-positive, and is Flt3-negative." diff --git a/src/ontology/subsets/BDS_subset.owl b/src/ontology/subsets/BDS_subset.owl index 8d6e5cc7a..bf18ea98a 100644 --- a/src/ontology/subsets/BDS_subset.owl +++ b/src/ontology/subsets/BDS_subset.owl @@ -1,6 +1,6 @@ - - + + + 2021-06-29 + @@ -648,9 +652,9 @@ - + - + @@ -1407,6 +1411,12 @@ + + + + + + @@ -1449,6 +1459,7 @@ this day is part of this year (occurrent parthood) a core relation that holds between a part and its whole Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other. + Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/ Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.) @@ -1495,6 +1506,7 @@ A continuant cannot be part of an occurrent: use 'participates in'. An Q1 has_part Q2 if and only if: every instance of Q1 is a quality_of an entity that has_quality some Q2. a core relation that holds between a whole and its part Everything has itself as a part. Any part of any part of a thing is itself part of that thing. Two distinct things cannot have each other as a part. + Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/ Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime Parthood requires the part and the whole to have compatible classes: only an occurrent have an occurrent as part; only a process can have a process as part; only a continuant can have a continuant as part; only an independent continuant can have an independent continuant as part; only a specifically dependent continuant can have a specifically dependent continuant as part; only a generically dependent continuant can have a generically dependent continuant as part. (This list is not exhaustive.) @@ -2086,13 +2098,19 @@ A continuant cannot have an occurrent as part: use 'participates in'. + inheres in this fragility inheres in this vase + this fragility is a characteristic of this vase this red color inheres in this apple + this red color is a characteristic of this apple + a relation between a specifically dependent continuant (the characteristic) and any other entity (the bearer), in which the characteristic depends on the bearer for its existence. a relation between a specifically dependent continuant (the dependent) and an independent continuant (the bearer), in which the dependent specifically depends on the bearer for its existence A dependent inheres in its bearer at all times for which the dependent exists. inheres_in + Note that this relation was previously called "inheres in", but was changed to be called "characteristic of" because BFO2 uses "inheres in" in a more restricted fashion. This relation differs from BFO2:inheres_in in two respects: (1) it does not impose a range constraint, and thus it allows qualities of processes, as well as of information entities, whereas BFO2 restricts inheres_in to only apply to independent continuants (2) it is declared functional, i.e. something can only be a characteristic of one thing. + characteristic of inheres in @@ -2101,10 +2119,12 @@ A continuant cannot have an occurrent as part: use 'participates in'. + bearer of this apple is bearer of this red color this vase is bearer of this fragility + Inverse of characteristic_of a relation between an independent continuant (the bearer) and a specifically dependent continuant (the dependent), in which the dependent specifically depends on the bearer for its existence A bearer can have many dependents, and its dependents can exist for different periods of time, but none of its dependents can exist when the bearer does not exist. bearer_of @@ -2116,6 +2136,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. bearer_of bearer of bearer of + has characteristic @@ -2167,14 +2188,83 @@ A continuant cannot have an occurrent as part: use 'participates in'. + + + + + + this catalysis function is a function of this enzyme + a relation between a function and an independent continuant (the bearer), in which the function specifically depends on the bearer for its existence + A function inheres in its bearer at all times for which the function exists, however the function need not be realized at all the times that the function exists. + function_of + is function of + This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020. + function of + + + + + + + + + + this red color is a quality of this apple + a relation between a quality and an independent continuant (the bearer), in which the quality specifically depends on the bearer for its existence + A quality inheres in its bearer at all times for which the quality exists. + is quality of + quality_of + This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020. + quality of + + + + + + + + + + this investigator role is a role of this person + a relation between a role and an independent continuant (the bearer), in which the role specifically depends on the bearer for its existence + A role inheres in its bearer at all times for which the role exists, however the role need not be realized at all the times that the role exists. + is role of + role_of + This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020. + role of + + + + + + + + + + this enzyme has function this catalysis function (more colloquially: this enzyme has this catalysis function) + a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence + A bearer can have many functions, and its functions can exist for different periods of time, but none of its functions can exist when the bearer does not exist. A function need not be realized at all the times that the function exists. + has_function + has function + + + + + + + this apple has quality this red color + a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence + A bearer can have many qualities, and its qualities can exist for different periods of time, but none of its qualities can exist when the bearer does not exist. + has_quality RO:0000086 protein has_quality false has_quality + has quality has_quality @@ -2183,6 +2273,12 @@ A continuant cannot have an occurrent as part: use 'participates in'. + + + this person has role this investigator role (more colloquially: this person has this role of investigator) + a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence + A bearer can have many roles, and its roles can exist for different periods of time, but none of its roles can exist when the bearer does not exist. A role need not be realized at all the times that the role exists. + has_role RO:0000087 chebi_ontology has_role @@ -2190,6 +2286,31 @@ A continuant cannot have an occurrent as part: use 'participates in'. false has_role has role + has role + + + + + + + + + + + a relation between an independent continuant (the bearer) and a disposition, in which the disposition specifically depends on the bearer for its existence + has disposition + + + + + + + + + inverse of has disposition + + This relation is modeled after the BFO relation of the same name which was in BFO2, but is used in a more restricted sense - specifically, we model this relation as functional (inherited from characteristic-of). Note that this relation is now removed from BFO2020. + disposition of @@ -2241,7 +2362,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. my head is the location of my brain this cage is the location of this rat a relation between two independent continuants, the location and the target, in which the target is entirely within the location - Most location relations will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime + Most location relations will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/ location_of RO:0001015 @@ -2310,7 +2431,7 @@ range: spatial region or site (immaterial continuant) this rat is located in this cage a relation between two independent continuants, the target and the location, in which the target is entirely within the location Location as a relation between instances: The primitive instance-level relation c located_in r at t reflects the fact that each continuant is at any given time associated with exactly one spatial region, namely its exact location. Following we can use this relation to define a further instance-level location relation - not between a continuant and the region which it exactly occupies, but rather between one continuant and another. c is located in c1, in this sense, whenever the spatial region occupied by c is part_of the spatial region occupied by c1. Note that this relation comprehends both the relation of exact location between one continuant and another which obtains when r and r1 are identical (for example, when a portion of fluid exactly fills a cavity), as well as those sorts of inexact location relations which obtain, for example, between brain and head or between ovum and uterus - Most location relations will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime + Most location relations will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/ located_in http://www.obofoundry.org/ro/#OBO_REL:located_in @@ -2387,6 +2508,7 @@ range: spatial region or site (immaterial continuant) David Osumi-Sutherland + has synaptic terminal of @@ -3145,7 +3267,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. spatially disjoint from - https://github.com/obophenotype/uberon/wiki/Part-disjointness-Design-Pattern + https://github.com/obophenotype/uberon/wiki/Part-disjointness-Design-Pattern @@ -3167,8 +3289,8 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.connected to connected to - https://github.com/obophenotype/uberon/wiki/Connectivity-Design-Pattern - https://github.com/obophenotype/uberon/wiki/Modeling-articulations-Design-Pattern + https://github.com/obophenotype/uberon/wiki/Connectivity-Design-Pattern + https://github.com/obophenotype/uberon/wiki/Modeling-articulations-Design-Pattern @@ -3516,6 +3638,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.capable_of_part_of capable of part of capable of part of + @@ -3942,12 +4065,17 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. + q characteristic of part of w if and only if there exists some p such that q inheres in p and p part of w. q inheres in part of w if and only if there exists some p such that q inheres in p and p part of w. + Because part_of is transitive, inheres in is a sub-relation of characteristic of part of Because part_of is transitive, inheres in is a sub-relation of inheres in part of Chris Mungall + inheres in part of + characteristic of part of inheres in part of + @@ -4640,6 +4768,8 @@ Each of these 3 primitives can be composed to yield a cross-product of different interacts with http://purl.obolibrary.org/obo/MI_0914 + http://purl.obolibrary.org/obo/ro/docs/interaction-relations/ + http://purl.obolibrary.org/obo/MI_0914 https://github.com/oborel/obo-relations/wiki/InteractionRelations @@ -4657,6 +4787,7 @@ Each of these 3 primitives can be composed to yield a cross-product of different molecularly interacts with http://purl.obolibrary.org/obo/MI_0915 + http://purl.obolibrary.org/obo/MI_0915 @@ -4975,7 +5106,7 @@ For example, A and B may be gene products and binding of B by A positively regul immediately transforms from - SIO:000658 + SIO:000658 @@ -5125,6 +5256,7 @@ For example, A and B may be gene products and binding of B by A positively regul Chris Mungall interaction relation helper property + http://purl.obolibrary.org/obo/ro/docs/interaction-relations/ https://github.com/oborel/obo-relations/wiki/InteractionRelations @@ -6356,7 +6488,7 @@ For example, A and B may be gene products and binding of B by A positively regul protein residue - PRO:DAN + PRO:DAN @@ -7334,7 +7466,7 @@ For example, A and B may be gene products and binding of B by A positively regul NGF cell - PMID:18568015 + PMID:18568015 @@ -8663,7 +8795,14 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + + + A glutamatergic neuron, with a soma found in the deeper portion of L5, that has long-range axonal projections including deep subcortical targets outside of the telencephalon and, in some cases, the spinal cord. While the L5 ET neuron projections are not limited to ET targets, they are clearly differentiated from the neuron subclasses whose projections are constrained to intratelencephalic (IT) targets. L5 ET neurons are generally the largest excitatory cortical neurons, typically having a thick apical dendrite with a prominent dendritic tuft in layer 1 and displaying burst-firing physiological characteristics. L5b neuron @@ -11318,13 +11457,14 @@ For example, A and B may be gene products and binding of B by A positively regul GC_ID:1 ncbi_taxonomy all + NCBITaxon:1 root all - + @@ -11333,10 +11473,11 @@ For example, A and B may be gene products and binding of B by A positively regul - + GC_ID:1 PMID:15371245 ncbi_taxonomy + NCBITaxon:10066 Muridae @@ -11346,31 +11487,32 @@ For example, A and B may be gene products and binding of B by A positively regul - + GC_ID:1 Mus mice mouse ncbi_taxonomy + NCBITaxon:10088 Mus <genus> Mus - + mice - + mouse - + @@ -11379,7 +11521,7 @@ For example, A and B may be gene products and binding of B by A positively regul - + NCBITaxon:85055 GC_ID:1 house mouse @@ -11394,19 +11536,19 @@ For example, A and B may be gene products and binding of B by A positively regul house mouse - + mouse - + m - PRO:DAN + PRO:DAN @@ -11422,9 +11564,9 @@ For example, A and B may be gene products and binding of B by A positively regul - GC_ID:1 ncbi_taxonomy + NCBITaxon:117570 Teleostomi @@ -11434,18 +11576,18 @@ For example, A and B may be gene products and binding of B by A positively regul - NCBITaxon:40673 GC_ID:1 bony vertebrates ncbi_taxonomy + NCBITaxon:117571 Euteleostomi bony vertebrates - + @@ -11457,13 +11599,14 @@ For example, A and B may be gene products and binding of B by A positively regul GC_ID:1 ncbi_taxonomy biota + NCBITaxon:131567 cellular organisms biota - + @@ -11472,9 +11615,9 @@ For example, A and B may be gene products and binding of B by A positively regul - GC_ID:1 ncbi_taxonomy + NCBITaxon:1338369 Dipnotetrapodomorpha @@ -11484,19 +11627,19 @@ For example, A and B may be gene products and binding of B by A positively regul - GC_ID:1 PMID:11743200 PMID:11791233 ncbi_taxonomy Boreotheria + NCBITaxon:1437010 Boreoeutheria Boreotheria - + @@ -11505,24 +11648,25 @@ For example, A and B may be gene products and binding of B by A positively regul - + GC_ID:1 mice and others ncbi_taxonomy Sciurognathi + NCBITaxon:1963758 Myomorpha mice and others - + Sciurognathi - + @@ -11532,7 +11676,7 @@ For example, A and B may be gene products and binding of B by A positively regul - + GC_ID:1 PMID:23020233 PMID:30257078 @@ -11552,50 +11696,50 @@ For example, A and B may be gene products and binding of B by A positively regul eucaryotes - + eukaryotes - + Eucarya - + Eucaryotae - + Eukarya - + Eukaryotae - + euk- - PRO:DAN + PRO:DAN eukaryotes - + @@ -11604,13 +11748,14 @@ For example, A and B may be gene products and binding of B by A positively regul - + GC_ID:1 PMID:11214319 PMID:12082125 PMID:12878460 PMID:15522813 ncbi_taxonomy + NCBITaxon:314146 Euarchontoglires @@ -11620,20 +11765,20 @@ For example, A and B may be gene products and binding of B by A positively regul - GC_ID:1 PMID:11214319 PMID:12082125 PMID:15522813 Rodents and rabbits ncbi_taxonomy + NCBITaxon:314147 Glires Rodents and rabbits - + @@ -11642,17 +11787,17 @@ For example, A and B may be gene products and binding of B by A positively regul - GC_ID:1 tetrapods ncbi_taxonomy + NCBITaxon:32523 Tetrapoda tetrapods - + @@ -11661,17 +11806,17 @@ For example, A and B may be gene products and binding of B by A positively regul - GC_ID:1 amniotes ncbi_taxonomy + NCBITaxon:32524 Amniota amniotes - + @@ -11680,17 +11825,17 @@ For example, A and B may be gene products and binding of B by A positively regul - GC_ID:1 Theria ncbi_taxonomy + NCBITaxon:32525 Theria <mammals> Theria - + @@ -11699,7 +11844,6 @@ For example, A and B may be gene products and binding of B by A positively regul - GC_ID:1 ncbi_taxonomy Fungi/Metazoa group @@ -11711,13 +11855,13 @@ For example, A and B may be gene products and binding of B by A positively regul Fungi/Metazoa group - + opisthokonts - + @@ -11726,7 +11870,7 @@ For example, A and B may be gene products and binding of B by A positively regul - + GC_ID:1 metazoans multicellular animals @@ -11741,31 +11885,31 @@ For example, A and B may be gene products and binding of B by A positively regul metazoans - + multicellular animals - + Animalia - + animals - + metazoan- - PRO:DAN + PRO:DAN @@ -11775,9 +11919,9 @@ For example, A and B may be gene products and binding of B by A positively regul - GC_ID:1 ncbi_taxonomy + NCBITaxon:33213 Bilateria @@ -11787,17 +11931,17 @@ For example, A and B may be gene products and binding of B by A positively regul - GC_ID:1 deuterostomes ncbi_taxonomy + NCBITaxon:33511 Deuterostomia deuterostomes - + @@ -11806,11 +11950,11 @@ For example, A and B may be gene products and binding of B by A positively regul - GC_ID:1 PMID:15019624 PMID:15371245 ncbi_taxonomy + NCBITaxon:337687 Muroidea @@ -11820,10 +11964,11 @@ For example, A and B may be gene products and binding of B by A positively regul - + NCBITaxon:109679 GC_ID:1 ncbi_taxonomy + NCBITaxon:39107 Murinae @@ -11833,7 +11978,7 @@ For example, A and B may be gene products and binding of B by A positively regul - + GC_ID:1 mammal mammals @@ -11853,20 +11998,20 @@ For example, A and B may be gene products and binding of B by A positively regul mammals - + mammal- - PRO:DAN + PRO:DAN mammals - + @@ -11875,9 +12020,9 @@ For example, A and B may be gene products and binding of B by A positively regul - GC_ID:1 ncbi_taxonomy + NCBITaxon:6072 Eumetazoa @@ -11887,24 +12032,25 @@ For example, A and B may be gene products and binding of B by A positively regul - + GC_ID:1 chordates ncbi_taxonomy chordates + NCBITaxon:7711 Chordata chordates - + chordates - + @@ -11913,31 +12059,31 @@ For example, A and B may be gene products and binding of B by A positively regul - GC_ID:1 Vertebrata vertebrates ncbi_taxonomy vertebrates + NCBITaxon:7742 Vertebrata <vertebrates> Vertebrata - + vertebrates - + vertebrates - + @@ -11946,24 +12092,24 @@ For example, A and B may be gene products and binding of B by A positively regul - GC_ID:1 Gnathostomata jawed vertebrates ncbi_taxonomy + NCBITaxon:7776 Gnathostomata <vertebrates> Gnathostomata - + jawed vertebrates - + @@ -11972,9 +12118,10 @@ For example, A and B may be gene products and binding of B by A positively regul - + GC_ID:1 ncbi_taxonomy + NCBITaxon:8287 Sarcopterygii @@ -11984,17 +12131,18 @@ For example, A and B may be gene products and binding of B by A positively regul - + GC_ID:1 Mus ncbi_taxonomy + NCBITaxon:862507 Mus <subgenus> Mus - + @@ -12003,17 +12151,18 @@ For example, A and B may be gene products and binding of B by A positively regul - + GC_ID:1 Craniata ncbi_taxonomy + NCBITaxon:89593 Craniata <chordates> Craniata - + @@ -12022,7 +12171,6 @@ For example, A and B may be gene products and binding of B by A positively regul - GC_ID:1 eutherian mammals placental mammals @@ -12030,37 +12178,38 @@ For example, A and B may be gene products and binding of B by A positively regul ncbi_taxonomy Placentalia placentals + NCBITaxon:9347 Eutheria eutherian mammals - + placental mammals - + placentals - + Placentalia - + placentals - + @@ -12069,7 +12218,7 @@ For example, A and B may be gene products and binding of B by A positively regul - + GC_ID:1 rodent ncbi_taxonomy @@ -12081,7 +12230,7 @@ For example, A and B may be gene products and binding of B by A positively regul rodent - + @@ -12093,7 +12242,7 @@ For example, A and B may be gene products and binding of B by A positively regul rodents - + @@ -12764,14 +12913,14 @@ For example, A and B may be gene products and binding of B by A positively regul An amino acid chain that is produced de novo by ribosome-mediated translation of a genetically-encoded mRNA, and any derivatives thereof. - PRO:DAN - PRO:WCB + PRO:DAN + PRO:WCB natural protein - PRO:DAN + PRO:DAN @@ -12797,7 +12946,7 @@ For example, A and B may be gene products and binding of B by A positively regul A protein with core architecture consisting of asignal sequence, 5 Ig-like domains, followed by a transmembrane sequence, followed by a Protein tyrosine kinase domain (Pfam:PF07714). However, only 1-3 of the Ig domains are detected by the Pfam HMMs in most of the sequences. Pfam:PF00047 is most common, but other members of the Ig domain clan, Pfam:PF07679 and Pfam:PF07686 can be identified instead. The fourth Ig domain lacks the disulfide-bonded cysteines. - PRO:WCB + PRO:WCB @@ -12829,13 +12978,13 @@ For example, A and B may be gene products and binding of B by A positively regul A CSF-1/PDGF receptor-type tyrosine-protein kinase that is a translation product of the human PDGFRA gene or a 1:1 ortholog thereof. - PRO:WCB + PRO:WCB PDGFRA - PRO:DNx + PRO:DNx @@ -12888,8 +13037,8 @@ For example, A and B may be gene products and binding of B by A positively regul A collagen alpha chain that is a translation product of the human COL1A1 or COL1A2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. - PRO:CNA - PRO:DAN + PRO:CNA + PRO:DAN @@ -12911,13 +13060,13 @@ For example, A and B may be gene products and binding of B by A positively regul A collagen type I alpha chain that is a translation product of the human COL1A1 gene or a 1:1 ortholog thereof. - PRO:CNA + PRO:CNA COL1A1 - PRO:DNx + PRO:DNx @@ -12944,13 +13093,13 @@ For example, A and B may be gene products and binding of B by A positively regul A protein that is a translation product of the human CCK gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx CCK - PRO:DNx + PRO:DNx @@ -12974,13 +13123,13 @@ For example, A and B may be gene products and binding of B by A positively regul A nicotinic acetylcholine receptor protein that is a translation product of the human CHRNA7 gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx CHRNA7 - PRO:DNx + PRO:DNx @@ -13018,13 +13167,13 @@ For example, A and B may be gene products and binding of B by A positively regul A protein that is a translation product of the human LUM gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx LUM - PRO:DNx + PRO:DNx @@ -13066,13 +13215,13 @@ For example, A and B may be gene products and binding of B by A positively regul A protein that is a translation product of the human MEIS2 gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx MEIS2 - PRO:DNx + PRO:DNx @@ -13106,13 +13255,13 @@ For example, A and B may be gene products and binding of B by A positively regul A protein that is a translation product of the human PVALB gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx PVALB - PRO:DNx + PRO:DNx @@ -13146,13 +13295,13 @@ For example, A and B may be gene products and binding of B by A positively regul A protein that is a translation product of the human SNCG gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx SNCG - PRO:DNx + PRO:DNx @@ -13193,13 +13342,13 @@ For example, A and B may be gene products and binding of B by A positively regul A protein that is a translation product of the human SST gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx SST - PRO:DNx + PRO:DNx @@ -13229,26 +13378,26 @@ For example, A and B may be gene products and binding of B by A positively regul A protein that is a translation product of the human VIP gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx VIP - PRO:DNx + PRO:DNx vasoactive intestinal peptides - PRO:DNx + PRO:DNx vasoactive intestinal polypeptides - PRO:DNx + PRO:DNx @@ -13275,20 +13424,20 @@ For example, A and B may be gene products and binding of B by A positively regul An organic amino compound that consists of amino acid residues (unmodified amino-acid residues and/or modified amino-acid residues) linked by peptide bonds or derivatives of such bonds. - PRO:DAN + PRO:DAN PRO:JSG peptide - PRO:DAN + PRO:DAN polypeptide - PRO:DAN + PRO:DAN @@ -13324,13 +13473,13 @@ For example, A and B may be gene products and binding of B by A positively regul A protein that is encoded in the genome of Mus musculus. - PRO:DAN + PRO:DAN mouse protein - PRO:DAN + PRO:DAN @@ -13357,13 +13506,13 @@ For example, A and B may be gene products and binding of B by A positively regul A protein that is a translation product of the human LAMP5 gene or a 1:1 ortholog thereof. - PRO:DNx + PRO:DNx LAMP5 - PRO:DNx + PRO:DNx @@ -13406,13 +13555,13 @@ For example, A and B may be gene products and binding of B by A positively regul A protein that is encoded in the genome of some Eukaryota. - PRO:DAN + PRO:DAN Eukaryota protein - PRO:DAN + PRO:DAN @@ -13538,7 +13687,7 @@ For example, A and B may be gene products and binding of B by A positively regul fam:chan - PRO:DAN + PRO:DAN @@ -13591,13 +13740,6 @@ For example, A and B may be gene products and binding of B by A positively regul Category=family. ion channel protein - - - - fam:ion_chan - PRO:DAN - - @@ -13605,6 +13747,13 @@ For example, A and B may be gene products and binding of B by A positively regul IUPHARfam:689 PRO:XQ + + + + fam:ion_chan + PRO:DAN + + @@ -13645,7 +13794,7 @@ For example, A and B may be gene products and binding of B by A positively regul A cholecystokinin that is encoded in the genome of mouse. OMA:P09240 - PRO:DNx + PRO:DNx @@ -13657,7 +13806,7 @@ For example, A and B may be gene products and binding of B by A positively regul mCCK - PRO:DNx + PRO:DNx @@ -13708,7 +13857,7 @@ For example, A and B may be gene products and binding of B by A positively regul A collagen alpha-1(I) chain that is encoded in the genome of mouse. OMA:P11087 - PRO:DNx + PRO:DNx @@ -13720,7 +13869,7 @@ For example, A and B may be gene products and binding of B by A positively regul mCOL1A1 - PRO:DNx + PRO:DNx @@ -13783,7 +13932,7 @@ For example, A and B may be gene products and binding of B by A positively regul An alpha-type platelet-derived growth factor receptor that is encoded in the genome of mouse. OMA:P26618 - PRO:DNx + PRO:DNx @@ -13825,7 +13974,7 @@ For example, A and B may be gene products and binding of B by A positively regul mPDGFRA - PRO:DNx + PRO:DNx @@ -13880,13 +14029,13 @@ For example, A and B may be gene products and binding of B by A positively regul A VIP peptides that is encoded in the genome of mouse. OMA:P32648 - PRO:DNx + PRO:DNx mVIP - PRO:DNx + PRO:DNx @@ -13936,13 +14085,13 @@ For example, A and B may be gene products and binding of B by A positively regul A parvalbumin alpha that is encoded in the genome of mouse. OMA:P32848 - PRO:DNx + PRO:DNx mPVALB - PRO:DNx + PRO:DNx @@ -14002,7 +14151,7 @@ For example, A and B may be gene products and binding of B by A positively regul A lumican that is encoded in the genome of mouse. OMA:P51885 - PRO:DNx + PRO:DNx @@ -14020,7 +14169,7 @@ For example, A and B may be gene products and binding of B by A positively regul mLUM - PRO:DNx + PRO:DNx @@ -14084,13 +14233,13 @@ For example, A and B may be gene products and binding of B by A positively regul A somatostatin that is encoded in the genome of mouse. OMA:P60041 - PRO:DNx + PRO:DNx mSST - PRO:DNx + PRO:DNx @@ -14149,7 +14298,7 @@ For example, A and B may be gene products and binding of B by A positively regul A homeobox protein Meis2 that is encoded in the genome of mouse. OMA:P97367 - PRO:DNx + PRO:DNx @@ -14161,7 +14310,7 @@ For example, A and B may be gene products and binding of B by A positively regul mMEIS2 - PRO:DNx + PRO:DNx @@ -14229,7 +14378,7 @@ For example, A and B may be gene products and binding of B by A positively regul A lysosome-associated membrane glycoprotein 5 that is encoded in the genome of mouse. OMA:Q9D387 - PRO:DNx + PRO:DNx @@ -14265,7 +14414,7 @@ For example, A and B may be gene products and binding of B by A positively regul mLAMP5 - PRO:DNx + PRO:DNx @@ -18535,7 +18684,7 @@ For example, A and B may be gene products and binding of B by A positively regul 2012-08-14 VSAO:0000101 VSAO - PSPUB:0000170 + PSPUB:0000170 @@ -19749,7 +19898,7 @@ For example, A and B may be gene products and binding of B by A positively regul VSAO:0000027 VSAO GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 - PSPUB:0000170 + PSPUB:0000170 @@ -21483,7 +21632,7 @@ For example, A and B may be gene products and binding of B by A positively regul - ZFA + ZFA @@ -22808,7 +22957,7 @@ For example, A and B may be gene products and binding of B by A positively regul - ZFA + ZFA @@ -22838,7 +22987,7 @@ For example, A and B may be gene products and binding of B by A positively regul 2012-08-14 VSAO:0000032 VSAO - PSPUB:0000170 + PSPUB:0000170 @@ -22970,7 +23119,7 @@ For example, A and B may be gene products and binding of B by A positively regul - ZFA + ZFA @@ -23317,7 +23466,7 @@ For example, A and B may be gene products and binding of B by A positively regul VHOG:0000150 VHOG - DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) + DOI:10.1046/j.1469-7580.2001.19910133.x Graham A. The development and evolution of the pharyngeal arches. J Anat (2001) @@ -23520,7 +23669,7 @@ For example, A and B may be gene products and binding of B by A positively regul GO_REF:0000034 - PSPUB:0000170 + PSPUB:0000170 VSAO:0000017 @@ -23548,8 +23697,8 @@ For example, A and B may be gene products and binding of B by A positively regul 2012-08-14 VSAO:0000017 VSAO - GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 - PSPUB:0000170 + GO_REF:0000034, http://dx.plos.org/10.1371/journal.pone.0051070 + PSPUB:0000170 @@ -24521,7 +24670,7 @@ For example, A and B may be gene products and binding of B by A positively regul A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA] - ISBN:0815318960 + ISBN:0815318960 OMD:neural+plate ZFIN:curator @@ -24734,7 +24883,7 @@ For example, A and B may be gene products and binding of B by A positively regul somitic mesoderm - ISBN:9780878932504 + ISBN:9780878932504 @@ -24853,7 +25002,7 @@ For example, A and B may be gene products and binding of B by A positively regul - ZFA + ZFA @@ -24886,7 +25035,7 @@ For example, A and B may be gene products and binding of B by A positively regul part_of somite in XAO - XAO + XAO @@ -24982,7 +25131,7 @@ For example, A and B may be gene products and binding of B by A positively regul VHOG:0000063 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 @@ -25503,7 +25652,7 @@ For example, A and B may be gene products and binding of B by A positively regul - ZFA + ZFA @@ -25519,7 +25668,7 @@ For example, A and B may be gene products and binding of B by A positively regul VHOG:0000796 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 @@ -25595,7 +25744,7 @@ For example, A and B may be gene products and binding of B by A positively regul VHOG:0000799 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 @@ -25658,7 +25807,7 @@ For example, A and B may be gene products and binding of B by A positively regul VHOG:0000798 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 @@ -25730,7 +25879,7 @@ For example, A and B may be gene products and binding of B by A positively regul - ZFA + ZFA @@ -25755,7 +25904,7 @@ For example, A and B may be gene products and binding of B by A positively regul VHOG:0001210 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 @@ -25825,7 +25974,7 @@ For example, A and B may be gene products and binding of B by A positively regul VHOG:0001006 VHOG - ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 + ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43 @@ -26865,7 +27014,7 @@ For example, A and B may be gene products and binding of B by A positively regul 2012-08-14 VSAO:0000128 VSAO - PSPUB:0000170 + PSPUB:0000170 @@ -28150,7 +28299,7 @@ For example, A and B may be gene products and binding of B by A positively regul 2012-08-14 VSAO:0000056 VSAO - PSPUB:0000170 + PSPUB:0000170 @@ -29076,7 +29225,7 @@ For example, A and B may be gene products and binding of B by A positively regul - ZFA + ZFA @@ -29301,7 +29450,7 @@ For example, A and B may be gene products and binding of B by A positively regul - ZFA + ZFA @@ -30191,7 +30340,7 @@ For example, A and B may be gene products and binding of B by A positively regul - ZFA + ZFA @@ -30286,7 +30435,7 @@ For example, A and B may be gene products and binding of B by A positively regul - ZFA + ZFA @@ -30297,7 +30446,7 @@ For example, A and B may be gene products and binding of B by A positively regul - ZFA + ZFA @@ -30544,7 +30693,7 @@ For example, A and B may be gene products and binding of B by A positively regul - ZFA + ZFA @@ -30595,7 +30744,7 @@ For example, A and B may be gene products and binding of B by A positively regul - ZFA + ZFA @@ -31093,7 +31242,7 @@ For example, A and B may be gene products and binding of B by A positively regul Anatomical structure that is an aggregation of similar cells from which cartilages and bones form, and from which chondrogenesis and osteogenesis are initiated during repair and/or regeneration. (Hall and Miyake 1995). GO_REF:0000034 - PSPUB:0000170 + PSPUB:0000170 VSAO:0000006 @@ -31202,7 +31351,7 @@ For example, A and B may be gene products and binding of B by A positively regul - ZFA + ZFA @@ -32394,7 +32543,7 @@ For example, A and B may be gene products and binding of B by A positively regul A protein coding gene Meis2 in mouse. - PRO:DNx + PRO:DNx @@ -32419,7 +32568,7 @@ For example, A and B may be gene products and binding of B by A positively regul A protein coding gene Lum in mouse. - PRO:DNx + PRO:DNx @@ -32444,7 +32593,7 @@ For example, A and B may be gene products and binding of B by A positively regul A protein coding gene Lamp5 in mouse. - PRO:DNx + PRO:DNx @@ -32469,7 +32618,7 @@ For example, A and B may be gene products and binding of B by A positively regul A protein coding gene Cck in mouse. - PRO:DNx + PRO:DNx @@ -32494,7 +32643,7 @@ For example, A and B may be gene products and binding of B by A positively regul A protein coding gene Col1a1 in mouse. - PRO:DNx + PRO:DNx @@ -32519,7 +32668,7 @@ For example, A and B may be gene products and binding of B by A positively regul A protein coding gene Pdgfra in mouse. - PRO:DNx + PRO:DNx @@ -32544,7 +32693,7 @@ For example, A and B may be gene products and binding of B by A positively regul A protein coding gene Pvalb in mouse. - PRO:DNx + PRO:DNx @@ -32569,7 +32718,7 @@ For example, A and B may be gene products and binding of B by A positively regul A protein coding gene Sst in mouse. - PRO:DNx + PRO:DNx @@ -32594,7 +32743,7 @@ For example, A and B may be gene products and binding of B by A positively regul A protein coding gene Vip in mouse. - PRO:DNx + PRO:DNx @@ -32652,6 +32801,12 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + + @@ -32749,6 +32904,49 @@ For example, A and B may be gene products and binding of B by A positively regul + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + true MF(X)-directly_regulates->MF(Y)-enabled_by->GP(Z) => MF(Y)-has_input->GP(Y) e.g. if 'protein kinase activity'(X) directly_regulates 'protein binding activity (Y)and this is enabled by GP(Z) then X has_input Z diff --git a/src/ontology/subsets/BDS_subset.tsv b/src/ontology/subsets/BDS_subset.tsv index aee903236..f5f5e9bff 100644 --- a/src/ontology/subsets/BDS_subset.tsv +++ b/src/ontology/subsets/BDS_subset.tsv @@ -1,141 +1,141 @@ ?x ?label -_:Bac8dcb9bX2Dd7b9X2D47acX2D9765X2Dcf2afbf997efgenid1001 -_:Bac8dcb9bX2Dd7b9X2D47acX2D9765X2Dcf2afbf997efgenid1010 -_:Bac8dcb9bX2Dd7b9X2D47acX2D9765X2Dcf2afbf997efgenid1020 -_:Bac8dcb9bX2Dd7b9X2D47acX2D9765X2Dcf2afbf997efgenid1035 -_:Bac8dcb9bX2Dd7b9X2D47acX2D9765X2Dcf2afbf997efgenid1043 -_:Bac8dcb9bX2Dd7b9X2D47acX2D9765X2Dcf2afbf997efgenid1052 -_:Bac8dcb9bX2Dd7b9X2D47acX2D9765X2Dcf2afbf997efgenid1064 -_:Bac8dcb9bX2Dd7b9X2D47acX2D9765X2Dcf2afbf997efgenid1073 -_:Bac8dcb9bX2Dd7b9X2D47acX2D9765X2Dcf2afbf997efgenid1084 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+_:B79734188X2Df627X2D4200X2D8fdcX2De761413997d9genid711 +_:B79734188X2Df627X2D4200X2D8fdcX2De761413997d9genid760 +_:B79734188X2Df627X2D4200X2D8fdcX2De761413997d9genid77 +_:B79734188X2Df627X2D4200X2D8fdcX2De761413997d9genid809 +_:B79734188X2Df627X2D4200X2D8fdcX2De761413997d9genid816 +_:B79734188X2Df627X2D4200X2D8fdcX2De761413997d9genid958 +_:B79734188X2Df627X2D4200X2D8fdcX2De761413997d9genid968 +_:B79734188X2Df627X2D4200X2D8fdcX2De761413997d9genid976 +_:B79734188X2Df627X2D4200X2D8fdcX2De761413997d9genid983 +_:B79734188X2Df627X2D4200X2D8fdcX2De761413997d9genid995 "continuant" "occurrent" "independent continuant" diff --git a/src/patterns/definitions.owl b/src/patterns/definitions.owl index 9084fba04..9d0de322d 100644 --- a/src/patterns/definitions.owl +++ b/src/patterns/definitions.owl @@ -7,8 +7,8 @@ Prefix(rdfs:=) Ontology( - -Annotation(owl:versionInfo "2021-06-21"^^xsd:string) + +Annotation(owl:versionInfo "2021-06-29"^^xsd:string) ) \ No newline at end of file