From a77bb66d9196f44e6a505c649b54c6e9ce2a0398 Mon Sep 17 00:00:00 2001 From: Aleix Puig <94959119+aleixpuigb@users.noreply.github.com> Date: Wed, 9 Oct 2024 10:58:59 +0100 Subject: [PATCH] Fixes #2630 Use hyphens for immune cells (#2632) Fixes #2630 Use hyphens (e.g. CD8-alpha) for immune cells in labels, definitions and comments. --- src/ontology/cl-edit.owl | 116 +++++++++++++++++++-------------------- 1 file changed, 58 insertions(+), 58 deletions(-) diff --git a/src/ontology/cl-edit.owl b/src/ontology/cl-edit.owl index 1eb264e92..42bd70799 100644 --- a/src/ontology/cl-edit.owl +++ b/src/ontology/cl-edit.owl @@ -7744,7 +7744,7 @@ SubClassOf(obo:CL_0000502 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0070253)) # Class: obo:CL_0000503 (theca cell) -AnnotationAssertion(Annotation(oboInOwl:hasDbXref "MESH:D013799") Annotation(oboInOwl:hasDbXref "PMID:36758341") Annotation(oboInOwl:hasDbXref "PMID:15833266") obo:IAO_0000115 obo:CL_0000503 "A specialized stromal cell that forms the theca layer outside the basal lamina lining the ovarian follicle, appearing during the secondary follicle stage.") +AnnotationAssertion(Annotation(oboInOwl:hasDbXref "MESH:D013799") Annotation(oboInOwl:hasDbXref "PMID:15833266") Annotation(oboInOwl:hasDbXref "PMID:36758341") obo:IAO_0000115 obo:CL_0000503 "A specialized stromal cell that forms the theca layer outside the basal lamina lining the ovarian follicle, appearing during the secondary follicle stage.") AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000503 "BTO:0002850") AnnotationAssertion(rdfs:label obo:CL_0000503 "theca cell") SubClassOf(obo:CL_0000503 obo:CL_0000499) @@ -12708,29 +12708,29 @@ EquivalentClasses(obo:CL_0000996 ObjectIntersectionOf(obo:CL_0000991 ObjectSomeV SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000996 obo:CL_0000991) SubClassOf(obo:CL_0000996 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0000994)) -# Class: obo:CL_0000997 (immature CD8_alpha-negative CD11b-positive dendritic cell) +# Class: obo:CL_0000997 (immature CD8-alpha-negative CD11b-positive dendritic cell) -AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") obo:IAO_0000115 obo:CL_0000997 "Immature CD8_alpha-negative CD11b-positive dendritic cell is a CD8_alpha-negative CD11b-positive dendritic cell that is CD80-low, CD86-low, and MHCII-low.") +AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") obo:IAO_0000115 obo:CL_0000997 "Immature CD8-alpha-negative CD11b-positive dendritic cell is a CD8-alpha-negative CD11b-positive dendritic cell that is CD80-low, CD86-low, and MHCII-low.") AnnotationAssertion(rdfs:comment obo:CL_0000997 "Originally described in the dendritic cell ontology (DC_CL:0000010)(PMID:19243617).") -AnnotationAssertion(rdfs:label obo:CL_0000997 "immature CD8_alpha-negative CD11b-positive dendritic cell") +AnnotationAssertion(rdfs:label obo:CL_0000997 "immature CD8-alpha-negative CD11b-positive dendritic cell") EquivalentClasses(obo:CL_0000997 ObjectIntersectionOf(obo:CL_0000999 ObjectSomeValuesFrom(obo:RO_0015016 obo:GO_0042613) ObjectSomeValuesFrom(obo:RO_0015016 obo:PR_000001412) ObjectSomeValuesFrom(obo:RO_0015016 obo:PR_000001438))) SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000997 obo:CL_0000999) SubClassOf(obo:CL_0000997 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0002010)) -# Class: obo:CL_0000998 (CD8_alpha-negative CD11b-negative dendritic cell) +# Class: obo:CL_0000998 (CD8-alpha-negative CD11b-negative dendritic cell) -AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") Annotation(oboInOwl:hasDbXref "http://www.immgen.org/index_content.html") obo:IAO_0000115 obo:CL_0000998 "CD8_alpha-negative CD11b-negative dendritic cell is a conventional dendritic cell that is CD11b-negative, CD4-negative CD8_alpha-negative and is CD205-positive. This cell is able to cross- present antigen to CD8-alpha-positive T cells.") +AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") Annotation(oboInOwl:hasDbXref "http://www.immgen.org/index_content.html") obo:IAO_0000115 obo:CL_0000998 "CD8-alpha-negative CD11b-negative dendritic cell is a conventional dendritic cell that is CD11b-negative, CD4-negative CD8-alpha-negative and is CD205-positive. This cell is able to cross- present antigen to CD8-alpha-positive T cells.") AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000998 "DC.8-4-11b-") AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000998 "triple negative dendritic cell") AnnotationAssertion(rdfs:comment obo:CL_0000998 "These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000011)(PMID:19243617).") -AnnotationAssertion(rdfs:label obo:CL_0000998 "CD8_alpha-negative CD11b-negative dendritic cell") +AnnotationAssertion(rdfs:label obo:CL_0000998 "CD8-alpha-negative CD11b-negative dendritic cell") EquivalentClasses(obo:CL_0000998 ObjectIntersectionOf(obo:CL_0000990 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001004) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001012) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001084) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001026) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0002474))) SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0000998 obo:CL_0000990) SubClassOf(obo:CL_0000998 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0002010)) # Class: obo:CL_0000999 (CD4-positive CD11b-positive dendritic cell) -AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") obo:IAO_0000115 obo:CL_0000999 "CD8_alpha-negative CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-positive and is CD205-negative and CD8_alpha-negative.") +AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") obo:IAO_0000115 obo:CL_0000999 "CD8-alpha-negative CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-positive and is CD205-negative and CD8-alpha-negative.") AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0000999 "DC.4+") AnnotationAssertion(rdfs:comment obo:CL_0000999 "Defined as having a disposition to secreting anti-inflammatory cytokines. These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000012)(PMID:19243617).") AnnotationAssertion(rdfs:label obo:CL_0000999 "CD4-positive CD11b-positive dendritic cell") @@ -12738,57 +12738,57 @@ EquivalentClasses(obo:CL_0000999 ObjectIntersectionOf(obo:CL_0000990 ObjectSomeV SubClassOf(obo:CL_0000999 obo:CL_0002465) SubClassOf(obo:CL_0000999 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0002010)) -# Class: obo:CL_0001000 (CD8_alpha-positive CD11b-negative dendritic cell) +# Class: obo:CL_0001000 (CD8-alpha-positive CD11b-negative dendritic cell) -AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") obo:IAO_0000115 obo:CL_0001000 "CD8_alpha-positive CD11b-negative dendritic cell is a conventional dendritic cell that is CD11b-negative, CD4-negative and is CD205-positive and CD8_alpha-positive.") +AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") obo:IAO_0000115 obo:CL_0001000 "CD8-alpha-positive CD11b-negative dendritic cell is a conventional dendritic cell that is CD11b-negative, CD4-negative and is CD205-positive and CD8-alpha-positive.") AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0001000 "DC.8+") AnnotationAssertion(rdfs:comment obo:CL_0001000 "Cells are defined as having a disposition to secreting inflammatory cytokines. Originally described in the dendritic cell ontology (DC_CL:0000013)(PMID:19243617).") -AnnotationAssertion(rdfs:label obo:CL_0001000 "CD8_alpha-positive CD11b-negative dendritic cell") +AnnotationAssertion(rdfs:label obo:CL_0001000 "CD8-alpha-positive CD11b-negative dendritic cell") EquivalentClasses(obo:CL_0001000 ObjectIntersectionOf(obo:CL_0000990 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001004) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001012) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001026) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001084) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0001816) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0042590) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0050729))) SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0001000 obo:CL_0000990) SubClassOf(obo:CL_0001000 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0002010)) -# Class: obo:CL_0001001 (immature CD8_alpha-negative CD11b-negative dendritic cell) +# Class: obo:CL_0001001 (immature CD8-alpha-negative CD11b-negative dendritic cell) -AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") obo:IAO_0000115 obo:CL_0001001 "Immature CD8_alpha-negative CD11b-negative dendritic cell is a CD8_alpha-negative CD11b-negative dendritic cell that is CD80-low, CD86-low, and MHCII-low.") +AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") obo:IAO_0000115 obo:CL_0001001 "Immature CD8-alpha-negative CD11b-negative dendritic cell is a CD8-alpha-negative CD11b-negative dendritic cell that is CD80-low, CD86-low, and MHCII-low.") AnnotationAssertion(rdfs:comment obo:CL_0001001 "These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000014)(PMID:19243617).") -AnnotationAssertion(rdfs:label obo:CL_0001001 "immature CD8_alpha-negative CD11b-negative dendritic cell") +AnnotationAssertion(rdfs:label obo:CL_0001001 "immature CD8-alpha-negative CD11b-negative dendritic cell") EquivalentClasses(obo:CL_0001001 ObjectIntersectionOf(obo:CL_0000998 ObjectSomeValuesFrom(obo:RO_0015016 obo:GO_0042613) ObjectSomeValuesFrom(obo:RO_0015016 obo:PR_000001412) ObjectSomeValuesFrom(obo:RO_0015016 obo:PR_000001438))) SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0001001 obo:CL_0000998) SubClassOf(obo:CL_0001001 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0002010)) -# Class: obo:CL_0001002 (mature CD8_alpha-negative CD11b-negative dendritic cell) +# Class: obo:CL_0001002 (mature CD8-alpha-negative CD11b-negative dendritic cell) -AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") obo:IAO_0000115 obo:CL_0001002 "Mature CD8_alpha-negative CD11b-negative dendritic cell is a CD8_alpha-negative CD11b-negative dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive.") +AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") obo:IAO_0000115 obo:CL_0001002 "Mature CD8-alpha-negative CD11b-negative dendritic cell is a CD8-alpha-negative CD11b-negative dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive.") AnnotationAssertion(rdfs:comment obo:CL_0001002 "These markers are associated with mouse cells. Defined as having a disposition to secretion of anti-inflammatory cytokines. Originally described in the dendritic cell ontology (DC_CL:0000015)(PMID:19243617).") -AnnotationAssertion(rdfs:label obo:CL_0001002 "mature CD8_alpha-negative CD11b-negative dendritic cell") +AnnotationAssertion(rdfs:label obo:CL_0001002 "mature CD8-alpha-negative CD11b-negative dendritic cell") EquivalentClasses(obo:CL_0001002 ObjectIntersectionOf(obo:CL_0000998 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001310) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0001816) ObjectSomeValuesFrom(obo:RO_0015015 obo:GO_0042613) ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000001412) ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000001438))) SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0001002 obo:CL_0000998) SubClassOf(obo:CL_0001002 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0001001)) -# Class: obo:CL_0001003 (mature CD8_alpha-negative CD11b-positive dendritic cell) +# Class: obo:CL_0001003 (mature CD8-alpha-negative CD11b-positive dendritic cell) -AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") obo:IAO_0000115 obo:CL_0001003 "Mature CD8_alpha-negative CD11b-positive dendritic cell is a CD8_alpha-negative CD11b-positive dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive.") +AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") obo:IAO_0000115 obo:CL_0001003 "Mature CD8-alpha-negative CD11b-positive dendritic cell is a CD8-alpha-negative CD11b-positive dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive.") AnnotationAssertion(rdfs:comment obo:CL_0001003 "Originally described in the dendritic cell ontology (DC_CL:0000016)(PMID:19243617).") -AnnotationAssertion(rdfs:label obo:CL_0001003 "mature CD8_alpha-negative CD11b-positive dendritic cell") +AnnotationAssertion(rdfs:label obo:CL_0001003 "mature CD8-alpha-negative CD11b-positive dendritic cell") EquivalentClasses(obo:CL_0001003 ObjectIntersectionOf(obo:CL_0000999 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001310) ObjectSomeValuesFrom(obo:RO_0015015 obo:GO_0042613) ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000001412) ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000001438))) SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0001003 obo:CL_0000999) SubClassOf(obo:CL_0001003 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0000997)) -# Class: obo:CL_0001004 (immature CD8_alpha-positive CD11b-negative dendritic cell) +# Class: obo:CL_0001004 (immature CD8-alpha-positive CD11b-negative dendritic cell) -AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") obo:IAO_0000115 obo:CL_0001004 "Immature CD8_alpha-positive CD11b-negative dendritic cell is a CD8_alpha-positive CD11b-negative dendritic cell that is CD80-low, CD86-low, and MHCII-low.") +AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") obo:IAO_0000115 obo:CL_0001004 "Immature CD8-alpha-positive CD11b-negative dendritic cell is a CD8-alpha-positive CD11b-negative dendritic cell that is CD80-low, CD86-low, and MHCII-low.") AnnotationAssertion(rdfs:comment obo:CL_0001004 "Originally described in the dendritic cell ontology (DC_CL:0000017)(PMID:19243617).") -AnnotationAssertion(rdfs:label obo:CL_0001004 "immature CD8_alpha-positive CD11b-negative dendritic cell") +AnnotationAssertion(rdfs:label obo:CL_0001004 "immature CD8-alpha-positive CD11b-negative dendritic cell") EquivalentClasses(obo:CL_0001004 ObjectIntersectionOf(obo:CL_0001000 ObjectSomeValuesFrom(obo:RO_0015016 obo:GO_0042613) ObjectSomeValuesFrom(obo:RO_0015016 obo:PR_000001412) ObjectSomeValuesFrom(obo:RO_0015016 obo:PR_000001438))) SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0001004 obo:CL_0001000) SubClassOf(obo:CL_0001004 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0002010)) -# Class: obo:CL_0001005 (mature CD8_alpha-positive CD11b-negative dendritic cell) +# Class: obo:CL_0001005 (mature CD8-alpha-positive CD11b-negative dendritic cell) -AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") obo:IAO_0000115 obo:CL_0001005 "Mature CD8_alpha-positive CD11b-negative dendritic cell is a CD8_alpha-positive CD11b-negative dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive.") +AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") obo:IAO_0000115 obo:CL_0001005 "Mature CD8-alpha-positive CD11b-negative dendritic cell is a CD8-alpha-positive CD11b-negative dendritic cell that is CD80-high, CD86-high, MHCII-high and is CD83-positive.") AnnotationAssertion(rdfs:comment obo:CL_0001005 "Originally described in the dendritic cell ontology (DC_CL:0000018)(PMID:19243617).") -AnnotationAssertion(rdfs:label obo:CL_0001005 "mature CD8_alpha-positive CD11b-negative dendritic cell") +AnnotationAssertion(rdfs:label obo:CL_0001005 "mature CD8-alpha-positive CD11b-negative dendritic cell") EquivalentClasses(obo:CL_0001005 ObjectIntersectionOf(obo:CL_0001000 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001310) ObjectSomeValuesFrom(obo:RO_0015015 obo:GO_0042613) ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000001412) ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000001438))) SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0001005 obo:CL_0001000) SubClassOf(obo:CL_0001005 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0001004)) @@ -12873,11 +12873,11 @@ AnnotationAssertion(rdfs:label obo:CL_0001014 "CD1a-positive Langerhans cell") EquivalentClasses(obo:CL_0001014 ObjectIntersectionOf(obo:CL_0000453 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001447) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002025))) SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0001014 obo:CL_0000453) -# Class: obo:CL_0001015 (CD8_alpha-low Langerhans cell) +# Class: obo:CL_0001015 (CD8-alpha-low Langerhans cell) -AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") obo:IAO_0000115 obo:CL_0001015 "CD8_alpha-low Langerhans cell is a Langerhans cell that is CD205-high and is CD8_alpha-low.") +AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") obo:IAO_0000115 obo:CL_0001015 "CD8-alpha-low Langerhans cell is a Langerhans cell that is CD205-high and is CD8-alpha-low.") AnnotationAssertion(rdfs:comment obo:CL_0001015 "These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000027)(PMID:19243617). They are also CD205-high, CD281-positive (TLR1), CD282-positive (TLR2), CD283-positive (TLR3), CD285-positive (TLR5), CD286-positive (TLR6), and CD289-positive (TLR9).") -AnnotationAssertion(rdfs:label obo:CL_0001015 "CD8_alpha-low Langerhans cell") +AnnotationAssertion(rdfs:label obo:CL_0001015 "CD8-alpha-low Langerhans cell") EquivalentClasses(obo:CL_0001015 ObjectIntersectionOf(obo:CL_0000453 ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000001026) ObjectSomeValuesFrom(obo:RO_0015016 obo:PR_000001084))) SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0001015 obo:CL_0000453) @@ -12898,11 +12898,11 @@ EquivalentClasses(obo:CL_0001017 ObjectIntersectionOf(obo:CL_0001014 ObjectSomeV SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0001017 obo:CL_0001014) SubClassOf(obo:CL_0001017 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0001016)) -# Class: obo:CL_0001018 (immature CD8_alpha-low Langerhans cell) +# Class: obo:CL_0001018 (immature CD8-alpha-low Langerhans cell) -AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") obo:IAO_0000115 obo:CL_0001018 "Immature CD8_alpha-low Langerhans cell is a CD8_alpha-low Langerhans cell that is CD80-low, CD86-low, and MHCII-low.") +AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") obo:IAO_0000115 obo:CL_0001018 "Immature CD8-alpha-low Langerhans cell is a CD8-alpha-low Langerhans cell that is CD80-low, CD86-low, and MHCII-low.") AnnotationAssertion(rdfs:comment obo:CL_0001018 "These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000030)(PMID:19243617).") -AnnotationAssertion(rdfs:label obo:CL_0001018 "immature CD8_alpha-low Langerhans cell") +AnnotationAssertion(rdfs:label obo:CL_0001018 "immature CD8-alpha-low Langerhans cell") EquivalentClasses(obo:CL_0001018 ObjectIntersectionOf(obo:CL_0001015 ObjectSomeValuesFrom(obo:RO_0015016 obo:GO_0042613) ObjectSomeValuesFrom(obo:RO_0015016 obo:PR_000001412) ObjectSomeValuesFrom(obo:RO_0015016 obo:PR_000001438))) SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0001018 obo:CL_0001015) SubClassOf(obo:CL_0001018 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0001019)) @@ -12914,11 +12914,11 @@ AnnotationAssertion(rdfs:label obo:CL_0001019 "CD115-positive monocyte OR common EquivalentClasses(obo:CL_0001019 ObjectUnionOf(obo:CL_0001022 obo:CL_0001029)) SubClassOf(obo:CL_0001019 obo:CL_0002031) -# Class: obo:CL_0001020 (mature CD8_alpha-low Langerhans cell) +# Class: obo:CL_0001020 (mature CD8-alpha-low Langerhans cell) -AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") obo:IAO_0000115 obo:CL_0001020 "Mature CD8_alpha-low Langerhans cell is a CD8_alpha-low Langerhans cell that that is CD80-high, CD86-high, MHCII-high and is CD83-positive.") +AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:amm") Annotation(oboInOwl:hasDbXref "GO_REF:0000031") Annotation(oboInOwl:hasDbXref "PMCID:PMC2346585") obo:IAO_0000115 obo:CL_0001020 "Mature CD8-alpha-low Langerhans cell is a CD8-alpha-low Langerhans cell that that is CD80-high, CD86-high, MHCII-high and is CD83-positive.") AnnotationAssertion(rdfs:comment obo:CL_0001020 "These markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000031)(PMID:19243617).") -AnnotationAssertion(rdfs:label obo:CL_0001020 "mature CD8_alpha-low Langerhans cell") +AnnotationAssertion(rdfs:label obo:CL_0001020 "mature CD8-alpha-low Langerhans cell") EquivalentClasses(obo:CL_0001020 ObjectIntersectionOf(obo:CL_0001015 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001310) ObjectSomeValuesFrom(obo:RO_0015015 obo:GO_0042613) ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000001412) ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000001438))) SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0001020 obo:CL_0001015) SubClassOf(obo:CL_0001020 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0001018)) @@ -14261,14 +14261,14 @@ EquivalentClasses(obo:CL_0002058 ObjectIntersectionOf(obo:CL_0000875 ObjectSomeV SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002058 obo:CL_0000875) SubClassOf(obo:CL_0002058 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0002398)) -# Class: obo:CL_0002059 (CD8alpha-positive thymic conventional dendritic cell) +# Class: obo:CL_0002059 (CD8-alpha-positive thymic conventional dendritic cell) -AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "PMID:19273629") Annotation(oboInOwl:hasDbXref "http://www.immgen.org/index_content.html") obo:IAO_0000115 obo:CL_0002059 "A conventional thymic dendritic cell that is CD8alpha-positive.") +AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "PMID:19273629") Annotation(oboInOwl:hasDbXref "http://www.immgen.org/index_content.html") obo:IAO_0000115 obo:CL_0002059 "A conventional thymic dendritic cell that is CD8-alpha-positive.") AnnotationAssertion(terms:contributor obo:CL_0002059 ) AnnotationAssertion(oboInOwl:creation_date obo:CL_0002059 "2010-06-07T02:48:36Z"^^xsd:dateTime) AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002059 "CD8alpha-alpha-positive thymic conventional dendritic cell") AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002059 "DC.8+.Th") -AnnotationAssertion(rdfs:label obo:CL_0002059 "CD8alpha-positive thymic conventional dendritic cell") +AnnotationAssertion(rdfs:label obo:CL_0002059 "CD8-alpha-positive thymic conventional dendritic cell") EquivalentClasses(obo:CL_0002059 ObjectIntersectionOf(obo:CL_0000941 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001084))) SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002059 obo:CL_0000941) @@ -17887,7 +17887,7 @@ SubClassOf(obo:CL_0002393 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0000860)) AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:dsd") Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "PMCID:PMC2882828") Annotation(oboInOwl:hasDbXref "PMCID:PMC2882837") Annotation(oboInOwl:hasDbXref "PMID:17332250") Annotation(oboInOwl:hasDbXref "PMID:20628149") obo:IAO_0000115 obo:CL_0002394 "A myeloid dendritic cell found in the blood, lymph nodes, tonsil, bone marrow, and spleen that is CD141-positive (BDCA-3), XCR1-positive, and Clec9A-positive. This cell-type can cross-present antigen to CD8-positive T cells and can produce inteferon-beta.") AnnotationAssertion(terms:contributor obo:CL_0002394 ) AnnotationAssertion(oboInOwl:creation_date obo:CL_0002394 "2010-10-04T02:38:58Z"^^xsd:dateTime) -AnnotationAssertion(rdfs:comment obo:CL_0002394 "Markers are found in human cells. Normally they represent 3-5% of peripheral blood mDCs (human). These cells express high levels of CD283 (TLR3), are capable of producing IL-12p70 and IFN-beta upon stimulation, and inducing a TH1 response [PMCID:PMC2882828]. They are also Necl2-positive. May be human equivalent of murine CD8alpha-positive DCs.") +AnnotationAssertion(rdfs:comment obo:CL_0002394 "Markers are found in human cells. Normally they represent 3-5% of peripheral blood mDCs (human). These cells express high levels of CD283 (TLR3), are capable of producing IL-12p70 and IFN-beta upon stimulation, and inducing a TH1 response [PMCID:PMC2882828]. They are also Necl2-positive. May be human equivalent of murine CD8-alpha-positive DCs.") AnnotationAssertion(rdfs:label obo:CL_0002394 "CD141-positive myeloid dendritic cell") EquivalentClasses(obo:CL_0002394 ObjectIntersectionOf(obo:CL_0000782 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000002105) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0002827) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0032606) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0042590))) SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002394 obo:CL_0000782) @@ -18498,34 +18498,34 @@ SubClassOf(obo:CL_0002453 ObjectIntersectionOf(obo:CL_0000123 ObjectSomeValuesFr SubClassOf(obo:CL_0002453 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0000339)) SubClassOf(obo:CL_0002453 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0030154)) -# Class: obo:CL_0002454 (Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell) +# Class: obo:CL_0002454 (CD4-negative, CD8-alpha-negative, CD11b-positive dendritic cell) -AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "http://www.immgen.org/index_content.html") obo:IAO_0000115 obo:CL_0002454 "Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-negative, CD8_alpha-negative and is CD205-positive.") +AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "http://www.immgen.org/index_content.html") obo:IAO_0000115 obo:CL_0002454 "CD4-negative, CD8-alpha-negative, CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-negative, CD8-alpha-negative and is CD205-positive.") AnnotationAssertion(terms:contributor obo:CL_0002454 ) AnnotationAssertion(oboInOwl:creation_date obo:CL_0002454 "2010-11-22T01:10:28Z"^^xsd:dateTime) AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002454 "DC.8-4-11b+") AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002454 "spleen double-negative dendritic cell") -AnnotationAssertion(rdfs:label obo:CL_0002454 "Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell") +AnnotationAssertion(rdfs:label obo:CL_0002454 "CD4-negative, CD8-alpha-negative, CD11b-positive dendritic cell") EquivalentClasses(obo:CL_0002454 ObjectIntersectionOf(obo:CL_0002465 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001004) ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001084))) SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002454 obo:CL_0002465) -# Class: obo:CL_0002455 (CD8_alpha-negative plasmacytoid dendritic cell) +# Class: obo:CL_0002455 (CD8-alpha-negative plasmacytoid dendritic cell) -AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "http://www.immgen.org/index_content.html") obo:IAO_0000115 obo:CL_0002455 "A CD11c-low plasmacytoid dendritic cell that is CD8alpha-negative and CD4-positive.") +AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "http://www.immgen.org/index_content.html") obo:IAO_0000115 obo:CL_0002455 "A CD11c-low plasmacytoid dendritic cell that is CD8-alpha-negative and CD4-positive.") AnnotationAssertion(terms:contributor obo:CL_0002455 ) AnnotationAssertion(oboInOwl:creation_date obo:CL_0002455 "2010-11-22T01:27:37Z"^^xsd:dateTime) AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002455 "DC.pDC.8-") -AnnotationAssertion(rdfs:label obo:CL_0002455 "CD8_alpha-negative plasmacytoid dendritic cell") +AnnotationAssertion(rdfs:label obo:CL_0002455 "CD8-alpha-negative plasmacytoid dendritic cell") EquivalentClasses(obo:CL_0002455 ObjectIntersectionOf(obo:CL_0000989 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001084) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001004))) SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002455 obo:CL_0000989) -# Class: obo:CL_0002456 (CD8_alpha-positive plasmacytoid dendritic cell) +# Class: obo:CL_0002456 (CD8-alpha-positive plasmacytoid dendritic cell) -AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "http://www.immgen.org/index_content.html") obo:IAO_0000115 obo:CL_0002456 "A CD11c-low plasmacytoid dendritic cell that is CD8alpha-positive and CD4-positive.") +AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "http://www.immgen.org/index_content.html") obo:IAO_0000115 obo:CL_0002456 "A CD11c-low plasmacytoid dendritic cell that is CD8-alpha-positive and CD4-positive.") AnnotationAssertion(terms:contributor obo:CL_0002456 ) AnnotationAssertion(oboInOwl:creation_date obo:CL_0002456 "2010-11-22T01:23:07Z"^^xsd:dateTime) AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002456 "DC.pDC.8+") -AnnotationAssertion(rdfs:label obo:CL_0002456 "CD8_alpha-positive plasmacytoid dendritic cell") +AnnotationAssertion(rdfs:label obo:CL_0002456 "CD8-alpha-positive plasmacytoid dendritic cell") EquivalentClasses(obo:CL_0002456 ObjectIntersectionOf(obo:CL_0000989 ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001004) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001084))) SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002456 obo:CL_0000989) @@ -18556,13 +18556,13 @@ AnnotationAssertion(rdfs:label obo:CL_0002459 "langerin-negative dermal dendriti EquivalentClasses(obo:CL_0002459 ObjectIntersectionOf(obo:CL_0001006 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001010) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001012))) SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002459 obo:CL_0001006) -# Class: obo:CL_0002460 (CD8alpha-negative thymic conventional dendritic cell) +# Class: obo:CL_0002460 (CD8-alpha-negative thymic conventional dendritic cell) -AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "PMID:19273629") Annotation(oboInOwl:hasDbXref "http://www.immgen.org/index_content.html") obo:IAO_0000115 obo:CL_0002460 "A conventional thymic dendritic cell that is CD8alpha-negative.") +AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "PMID:19273629") Annotation(oboInOwl:hasDbXref "http://www.immgen.org/index_content.html") obo:IAO_0000115 obo:CL_0002460 "A conventional thymic dendritic cell that is CD8-alpha-negative.") AnnotationAssertion(terms:contributor obo:CL_0002460 ) AnnotationAssertion(oboInOwl:creation_date obo:CL_0002460 "2010-11-23T10:58:53Z"^^xsd:dateTime) AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002460 "DC.8-.Th") -AnnotationAssertion(rdfs:label obo:CL_0002460 "CD8alpha-negative thymic conventional dendritic cell") +AnnotationAssertion(rdfs:label obo:CL_0002460 "CD8-alpha-negative thymic conventional dendritic cell") EquivalentClasses(obo:CL_0002460 ObjectIntersectionOf(obo:CL_0000941 ObjectSomeValuesFrom(obo:CL_4030046 obo:PR_000001084))) SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002460 obo:CL_0000941) @@ -19072,22 +19072,22 @@ AnnotationAssertion(rdfs:label obo:CL_0002512 "CD11b-high, CD103-negative, lange EquivalentClasses(obo:CL_0002512 ObjectIntersectionOf(obo:CL_0002508 ObjectSomeValuesFrom(obo:RO_0015015 obo:PR_000001012))) SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002512 obo:CL_0002508) -# Class: obo:CL_0002513 (Vgamma5-positive CD8alpha alpha positive gamma-delta intraepithelial T cell) +# Class: obo:CL_0002513 (Vgamma5-positive CD8-alpha alpha positive gamma-delta intraepithelial T cell) -AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "http://www.immgen.org/index_content.html") obo:IAO_0000115 obo:CL_0002513 "A CD8alpha alpha positive gamma-delta intraepithelial T cell that expresses a TCR encoded in part by the Vgamma5 gene segment.") +AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "http://www.immgen.org/index_content.html") obo:IAO_0000115 obo:CL_0002513 "A CD8-alpha alpha positive gamma-delta intraepithelial T cell that expresses a TCR encoded in part by the Vgamma5 gene segment.") AnnotationAssertion(terms:contributor obo:CL_0002513 ) AnnotationAssertion(oboInOwl:creation_date obo:CL_0002513 "2011-01-24T10:22:18Z"^^xsd:dateTime) AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002513 "tgd.vg5+.IEL") -AnnotationAssertion(rdfs:label obo:CL_0002513 "Vgamma5-positive CD8alpha alpha positive gamma-delta intraepithelial T cell") +AnnotationAssertion(rdfs:label obo:CL_0002513 "Vgamma5-positive CD8-alpha alpha positive gamma-delta intraepithelial T cell") SubClassOf(obo:CL_0002513 obo:CL_0000802) -# Class: obo:CL_0002514 (Vgamma5-negative CD8alpha alpha positive gamma-delta intraepithelial T cell) +# Class: obo:CL_0002514 (Vgamma5-negative CD8-alpha alpha positive gamma-delta intraepithelial T cell) -AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "http://www.immgen.org/index_content.html") obo:IAO_0000115 obo:CL_0002514 "A CD8alpha alpha positive gamma-delta intraepithelial T cell that does not express a TCR partially encoded by the Vgamma5 gene segment.") +AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "http://www.immgen.org/index_content.html") obo:IAO_0000115 obo:CL_0002514 "A CD8-alpha alpha positive gamma-delta intraepithelial T cell that does not express a TCR partially encoded by the Vgamma5 gene segment.") AnnotationAssertion(terms:contributor obo:CL_0002514 ) AnnotationAssertion(oboInOwl:creation_date obo:CL_0002514 "2011-01-24T10:25:44Z"^^xsd:dateTime) AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002514 "tgd.vg5-.IEL") -AnnotationAssertion(rdfs:label obo:CL_0002514 "Vgamma5-negative CD8alpha alpha positive gamma-delta intraepithelial T cell") +AnnotationAssertion(rdfs:label obo:CL_0002514 "Vgamma5-negative CD8-alpha alpha positive gamma-delta intraepithelial T cell") SubClassOf(obo:CL_0002514 obo:CL_0000802) # Class: obo:CL_0002515 (interrenal norepinephrine type cell) @@ -32737,7 +32737,7 @@ SubClassOf(obo:CL_4052011 obo:CL_0000584) # Class: obo:CL_4052012 (interna theca cell) -AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:31320652") Annotation(oboInOwl:hasDbXref "PMID:32530882") Annotation(oboInOwl:hasDbXref "Wikipedia:Theca_interna") Annotation(oboInOwl:hasDbXref "PMID:15833266") obo:IAO_0000115 obo:CL_4052012 "A specialized theca cell that forms the inner, highly vascularized layer of the theca surrounding ovarian follicles. Originating from progenitor theca cells, the theca interna cell is steroidogenic, playing a crucial role in the production of androgens, which serves as a precursor for estrogen synthesis in granulosa cells. This cell expresses luteinizing hormone receptors, enabling it to respond to hormonal signals that regulate steroidogenesis.") +AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:15833266") Annotation(oboInOwl:hasDbXref "PMID:31320652") Annotation(oboInOwl:hasDbXref "PMID:32530882") Annotation(oboInOwl:hasDbXref "Wikipedia:Theca_interna") obo:IAO_0000115 obo:CL_4052012 "A specialized theca cell that forms the inner, highly vascularized layer of the theca surrounding ovarian follicles. Originating from progenitor theca cells, the theca interna cell is steroidogenic, playing a crucial role in the production of androgens, which serves as a precursor for estrogen synthesis in granulosa cells. This cell expresses luteinizing hormone receptors, enabling it to respond to hormonal signals that regulate steroidogenesis.") AnnotationAssertion(terms:contributor obo:CL_4052012 ) AnnotationAssertion(terms:date obo:CL_4052012 "2024-09-30T11:10:15Z"^^xsd:dateTime) AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:31320652") Annotation(oboInOwl:hasSynonymType obo:OMO_0003000) oboInOwl:hasRelatedSynonym obo:CL_4052012 "inTC")