From a9f21027f9ec3196fa53ec822979be2973d2ac30 Mon Sep 17 00:00:00 2001 From: nicolevasilevsky Date: Wed, 20 May 2020 09:58:19 -0700 Subject: [PATCH] add new term CL_0011025 (exhausted T cell) closes #663 --- src/ontology/cl-edit.owl | 10 ++++++++++ 1 file changed, 10 insertions(+) diff --git a/src/ontology/cl-edit.owl b/src/ontology/cl-edit.owl index 854d7cb34..2507d6529 100644 --- a/src/ontology/cl-edit.owl +++ b/src/ontology/cl-edit.owl @@ -1894,6 +1894,7 @@ Declaration(Class(obo:CL_0011021)) Declaration(Class(obo:CL_0011022)) Declaration(Class(obo:CL_0011023)) Declaration(Class(obo:CL_0011024)) +Declaration(Class(obo:CL_0011025)) Declaration(Class(obo:CL_0011100)) Declaration(Class(obo:CL_0011101)) Declaration(Class(obo:CL_0011102)) @@ -22114,6 +22115,7 @@ AnnotationAssertion(rdfs:label obo:CL_0011023 "CD25+ mast cell") EquivalentClasses(obo:CL_0011023 ObjectIntersectionOf(obo:CL_0001063 ObjectSomeValuesFrom(obo:RO_0001000 obo:CL_0000097) ObjectSomeValuesFrom(obo:RO_0002104 obo:PR_000001380))) SubClassOf(obo:CL_0011023 obo:CL_0001063) + # Class: obo:CL_0011024 (double negative T regulatory cell) AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:16285891") obo:IAO_0000115 obo:CL_0011024 "A double negative thymocyte that is CD3-positive, CD4-negative, CD8-negative, that that are present in the periphery in very low numbers and predominantly produce INF-gamma, TNF-alpha, and a low amount of TGF-beta, but not IL-2, IL-4, IL-10 or IL-13 upon activation.") @@ -22125,6 +22127,14 @@ AnnotationAssertion(rdfs:label obo:CL_0011024 "double negative T regulatory cell EquivalentClasses(obo:CL_0011024 ObjectIntersectionOf(obo:CL_0002489 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0050777))) SubClassOf(obo:CL_0011024 obo:CL_0002489) +# Class: obo:CL_0011025 (exhausted T cell) + +AnnotationAssertion(oboInOwl:created_by obo:CL_0011025 ) +AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:26544946") oboInOwl:hasExactSynonym obo:CL_0011025 "An effector T cell that displays impaired effector functions (e.g., rapid production of effector cytokines, cytotoxicity) and has limited proliferative potential.") +AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0011025 "Tex cell") +AnnotationAssertion(rdfs:label obo:CL_0011025 "exhausted T cell") +SubClassOf(obo:CL_0011025 obo:CL_0000911) + # Class: obo:CL_0011100 (galanergic neuron) AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:NV") Annotation(oboInOwl:hasDbXref "PMID:23159249") Annotation(oboInOwl:hasDbXref "ZFIN:CVS") Annotation(oboInOwl:hasDbXref "ZFIN:YB") obo:IAO_0000115 obo:CL_0011100 "Neuron that secretes the neurotransmitter galanin.")