[NTR] lung T cell terms

[corismall]

Preferred term label

• Lung-resident Granzyme K-associated CD8 T cell #2646

Synonyms (add reference(s), please)
CD8-GZMK

Definition (free text, with reference(s), please. PubMed ID format is PMID:XXXXXX)
A CD8 T cell associated with Granzyme K found in lung tissue. Expresses GZMK.
Marker genes include CD8B, CD8A, GZMA, GZMB, GZMH, GZMM, GZMK, CD103 and CD49a, CCL4, CD5, CD2, CD8, CD3

References

• Maksimovic et al. 2022 (“Single-cell atlas of bronchoalveolar lavage from preschool cystic fibrosis reveals new cell phenotypes”, DOI:10.1101/2022.06.17.496207)

Parent cell type term (check the hierarchy here https://www.ebi.ac.uk/ols4/ontologies/cl)
Lung resident memory CD8-positive, CD103-positive, alpha-beta T cell (CL:4033040)

Anatomical structure where the cell type is found (check Uberon for anatomical structures: https://www.ebi.ac.uk/ols4/ontologies/uberon)
lung (UBERON:0002048)

Your ORCID
0000-0002-2336-2552

Additional notes or concerns

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Preferred term label
NFkB-associated CD4 T cell

Synonyms (add reference(s), please)
CD4 T-NFkB

Definition (free text, with reference(s), please. PubMed ID format is PMID:XXXXXX)
A CD4 T cell associated with several NEκB activation and signaling pathways. Expresses TNFRSF4, TNFRSF18, NFKB2.
Marker genes include IL411, TNFRSF4, TNFRSF18, IL2RA, NFKB2, ADAM19, CTSH, IL7R, MAF, CTLA4, LINC01943, CD5, CD2, CD7, CD3, CD4

References

• Maksimovic et al. 2022 (“Single-cell atlas of bronchoalveolar lavage from preschool cystic fibrosis reveals new cell phenotypes”, DOI:10.1101/2022.06.17.496207)

Parent cell type term (check the hierarchy here https://www.ebi.ac.uk/ols4/ontologies/cl)
CD4-positive, alpha-beta T cell (CL:0000624)

Anatomical structure where the cell type is found (check Uberon for anatomical structures: https://www.ebi.ac.uk/ols4/ontologies/uberon)
lung (UBERON:0002048)

Your ORCID
0000-0002-2336-2552

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Preferred term label
IFN-associated CD4 T cell

Synonyms (add reference(s), please)
CD4 T-IFN

Definition (free text, with reference(s), please. PubMed ID format is PMID:XXXXXX)
A CD4 T cell associated with inflammatory IFNα/β and antiviral pathways. Expresses IFIT1, IFIT3, RSAD2.
Marker genes include IFIT1, IFI144L, RSAD2, HERCS, OAS1, CD4, ADAM19, CD5, CD2, CD49a, CD3, CD4

References

• Maksimovic et al. 2022 (“Single-cell atlas of bronchoalveolar lavage from preschool cystic fibrosis reveals new cell phenotypes”, DOI:10.1101/2022.06.17.496207)

Parent cell type term (check the hierarchy here https://www.ebi.ac.uk/ols4/ontologies/cl)
CD4-positive, alpha-beta T cell (CL:0000624)

Anatomical structure where the cell type is found (check Uberon for anatomical structures: https://www.ebi.ac.uk/ols4/ontologies/uberon)
lung (UBERON:0002048)

Your ORCID
0000-0002-2336-2552