[NTR] preplasmablast

[emquardokus]

Please check that the term does not already exist by using the ontology search tool OLS:
https://www.ebi.ac.uk/ols4/ontologies/cl

Preferred term label
preplasmablast

Synonyms (add reference(s), please)
prePB (used in several published papers)

Definition (free text, with reference(s), please. PubMed ID format is PMID:XXXXXX)
Figure from Moreaux, Jerome. 2021.

Parent cell type term (check the hierarchy here https://www.ebi.ac.uk/ols4/ontologies/cl)
After digging through the literature I believe the Moreau paper had best evidence that preplasmablasts are in the lineage of naive B cells, but activated by Interleukin 4.

Anatomical structure where the cell type is found (check Uberon for anatomical structures: https://www.ebi.ac.uk/ols4/ontologies/uberon)

palatine tonsil UBERON:0002373 http://purl.obolibrary.org/obo/UBERON_0002373

literature citations
Moreaux, Jerome. 2021. “The Origin of Preplasmablastic Cells.” Blood 137 (9): 1134–35. https://doi.org/10.1182/blood.2020009746.

this citation provides markers of preplasmablasts and differences between plasmablasts and plasma cells Michel Jourdan, Anouk Caraux, Gersende Caron, Nicolas Robert, Geneviève Fiol, Thierry Rème, Karine Bolloré, Jean-Pierre Vendrell, Simon Le Gallou, Frédéric Mourcin, John De Vos, Alboukadel Kassambara, Christophe Duperray, Dirk Hose, Thierry Fest, Karin Tarte, Bernard Klein; Characterization of a Transitional Preplasmablast Population in the Process of Human B Cell to Plasma Cell Differentiation. J Immunol 15 October 2011; 187 (8): 3931–3941. https://doi.org/10.4049/jimmunol.1101230
"Preplasmablasts lack documented B cell or plasma cell (CD20, CD38, and CD138) markers, express CD30 and IL-6R, and secrete Igs at a weaker level than do plasmablasts or plasma cells. These preplasmablasts further differentiate into CD20−CD38highCD138− plasmablasts and then CD20−CD38highCD138+ plasma cells. "

Your ORCID
Ellen M. Quardokus 0000-0001-7655-4833

Additional notes or concerns
Not the same as plasmablast or plasma cell. This is a distinct cell type.

[dosumis]

@addiehl - please comment.

[aleixpuigb]

Thank you for the request.

In Jourdan et al., 2011, a counterpart of the described preplasmablast in vitro is found in lymph nodes and tonsils. We can add the relationship 'has part' preplasmablast in palatine tonsils, but I would not add 'preplasmablast SubclassOf 'part of' some 'palatine tonsil'.

The parent term can be mature B cell, which is already a parent term of 'naive B cell' and 'plasmablast'. I can also add 'develops into' some plasmablast and 'develops from' some 'naive B cell'.

Proposed definition:

A mature B cell that serves as an intermediate stage in the differentiation of naive B cells into a plasmablast. A preplasmablast expresses CD30 and IL-6R and lacks expression of CD20, CD23, CD38 and CD138.
PMID:33150420
PMID:21918187
PMID:30755708

Additional synonyms:
pre-plasmablast PMID:23613519
preplasmablastic cell PMID:33661294