diff --git a/src/mappings/fbbt.sssom.tsv b/src/mappings/fbbt.sssom.tsv index 1183babe8..ae3ff68eb 100644 --- a/src/mappings/fbbt.sssom.tsv +++ b/src/mappings/fbbt.sssom.tsv @@ -12,88 +12,87 @@ #subject_source: "obo:fbbt.owl" #object_source: "obo:cl.owl" #mapping_date: "2024-07-12" -subject_id subject_label predicate_id object_id mapping_justification -FBbt:00000092 primordial germ cell semapv:crossSpeciesExactMatch CL:0000301 semapv:ManualMappingCuration -FBbt:00000124 epithelial cell semapv:crossSpeciesExactMatch CL:0000066 semapv:ManualMappingCuration -FBbt:00001666 cardioblast semapv:crossSpeciesExactMatch CL:0000465 semapv:ManualMappingCuration -FBbt:00001685 embryonic/larval plasmatocyte semapv:crossSpeciesExactMatch CL:0000394 semapv:ManualMappingCuration -FBbt:00001687 lamellocyte semapv:crossSpeciesExactMatch CL:0000396 semapv:ManualMappingCuration -FBbt:00001689 procrystal cell semapv:crossSpeciesExactMatch CL:0000395 semapv:ManualMappingCuration -FBbt:00001690 embryonic/larval crystal cell semapv:crossSpeciesExactMatch CL:0000715 semapv:ManualMappingCuration -FBbt:00001691 polygonal cell semapv:crossSpeciesExactMatch CL:0000398 semapv:ManualMappingCuration -FBbt:00001789 histoblast semapv:crossSpeciesExactMatch CL:0000373 semapv:ManualMappingCuration -FBbt:00003219 adepithelial cell semapv:crossSpeciesExactMatch CL:0000462 semapv:ManualMappingCuration -FBbt:00003360 flight muscle cell semapv:crossSpeciesExactMatch CL:0000196 semapv:ManualMappingCuration -FBbt:00003686 Kenyon cell semapv:crossSpeciesExactMatch CL:0000673 semapv:ManualMappingCuration -FBbt:00004101 peptidergic neuron semapv:crossSpeciesExactMatch CL:0000110 semapv:ManualMappingCuration -FBbt:00004193 cone cell semapv:crossSpeciesExactMatch CL:0000718 semapv:ManualMappingCuration -FBbt:00004211 photoreceptor cell semapv:crossSpeciesExactMatch CL:0000210 semapv:ManualMappingCuration -FBbt:00004213 photoreceptor cell R1 semapv:crossSpeciesExactMatch CL:0000687 semapv:ManualMappingCuration -FBbt:00004215 photoreceptor cell R2 semapv:crossSpeciesExactMatch CL:0000690 semapv:ManualMappingCuration -FBbt:00004217 photoreceptor cell R3 semapv:crossSpeciesExactMatch CL:0000694 semapv:ManualMappingCuration -FBbt:00004219 photoreceptor cell R4 semapv:crossSpeciesExactMatch CL:0000697 semapv:ManualMappingCuration -FBbt:00004221 photoreceptor cell R5 semapv:crossSpeciesExactMatch CL:0000702 semapv:ManualMappingCuration -FBbt:00004223 photoreceptor cell R6 semapv:crossSpeciesExactMatch CL:0000705 semapv:ManualMappingCuration -FBbt:00004225 photoreceptor cell R7 semapv:crossSpeciesExactMatch CL:0000707 semapv:ManualMappingCuration -FBbt:00004227 photoreceptor cell R8 semapv:crossSpeciesExactMatch CL:0000709 semapv:ManualMappingCuration -FBbt:00004230 pigment cell semapv:crossSpeciesExactMatch CL:0001658 semapv:ManualMappingCuration -FBbt:00004861 germline stem cell semapv:crossSpeciesExactMatch CL:0000014 semapv:ManualMappingCuration -FBbt:00004873 female germline stem cell semapv:crossSpeciesExactMatch CL:0000022 semapv:ManualMappingCuration -FBbt:00004878 nurse cell semapv:crossSpeciesExactMatch CL:0000026 semapv:ManualMappingCuration -FBbt:00004886 oocyte semapv:crossSpeciesExactMatch CL:0000023 semapv:ManualMappingCuration -FBbt:00004903 follicle stem cell semapv:crossSpeciesExactMatch CL:0000441 semapv:ManualMappingCuration -FBbt:00004904 follicle cell semapv:crossSpeciesExactMatch CL:0000477 semapv:ManualMappingCuration -FBbt:00004905 border follicle cell semapv:crossSpeciesExactMatch CL:0000579 semapv:ManualMappingCuration -FBbt:00004906 centripetal follicle cell semapv:crossSpeciesExactMatch CL:0000671 semapv:ManualMappingCuration -FBbt:00004910 stalk follicle cell semapv:crossSpeciesExactMatch CL:0000674 semapv:ManualMappingCuration -FBbt:00004929 male germline stem cell semapv:crossSpeciesExactMatch CL:0000016 semapv:ManualMappingCuration -FBbt:00004934 primary gonial cell semapv:crossSpeciesExactMatch CL:0000020 semapv:ManualMappingCuration -FBbt:00004935 spermatogonium semapv:crossSpeciesExactMatch CL:0000020 semapv:ManualMappingCuration -FBbt:00004936 spermatocyte semapv:crossSpeciesExactMatch CL:0000017 semapv:ManualMappingCuration -FBbt:00004941 secondary spermatocyte semapv:crossSpeciesExactMatch CL:0000657 semapv:ManualMappingCuration -FBbt:00004942 spermatid semapv:crossSpeciesExactMatch CL:0000018 semapv:ManualMappingCuration -FBbt:00004954 spermatozoon semapv:crossSpeciesExactMatch CL:0000019 semapv:ManualMappingCuration -FBbt:00004994 epidermoblast semapv:crossSpeciesExactMatch CL:0000464 semapv:ManualMappingCuration -FBbt:00004995 oenocyte semapv:crossSpeciesExactMatch CL:0000487 semapv:ManualMappingCuration -FBbt:00005038 tracheocyte semapv:crossSpeciesExactMatch CL:0008026 semapv:ManualMappingCuration -FBbt:00005058 pericardial cell semapv:crossSpeciesExactMatch CL:0000474 semapv:ManualMappingCuration -FBbt:00005059 garland cell semapv:crossSpeciesExactMatch CL:0000486 semapv:ManualMappingCuration -FBbt:00005062 prohemocyte semapv:crossSpeciesExactMatch CL:0000385 semapv:ManualMappingCuration -FBbt:00005063 hemocyte semapv:crossSpeciesExactMatch CL:0000387 semapv:ManualMappingCuration -FBbt:00005070 visceral muscle cell semapv:crossSpeciesExactMatch CL:0008007 semapv:ManualMappingCuration -FBbt:00005073 somatic muscle cell semapv:crossSpeciesExactMatch CL:0008004 semapv:ManualMappingCuration -FBbt:00005074 muscle cell semapv:crossSpeciesExactMatch CL:0000187 semapv:ManualMappingCuration -FBbt:00005083 myoblast semapv:crossSpeciesExactMatch CL:0000056 semapv:ManualMappingCuration -FBbt:00005106 neuron semapv:crossSpeciesExactMatch CL:0000540 semapv:ManualMappingCuration -FBbt:00005123 motor neuron semapv:crossSpeciesExactMatch CL:0000100 semapv:ManualMappingCuration -FBbt:00005124 sensory neuron semapv:crossSpeciesExactMatch CL:0000101 semapv:ManualMappingCuration -FBbt:00005125 interneuron semapv:crossSpeciesExactMatch CL:0000099 semapv:ManualMappingCuration -FBbt:00005128 pioneer neuron semapv:crossSpeciesExactMatch CL:0000116 semapv:ManualMappingCuration -FBbt:00005130 neurosecretory neuron semapv:crossSpeciesExactMatch CL:0000165 semapv:ManualMappingCuration -FBbt:00005131 dopaminergic neuron semapv:crossSpeciesExactMatch CL:0000700 semapv:ManualMappingCuration -FBbt:00005133 serotonergic neuron semapv:crossSpeciesExactMatch CL:0000850 semapv:ManualMappingCuration -FBbt:00005144 glial cell semapv:crossSpeciesExactMatch CL:0000125 semapv:ManualMappingCuration -FBbt:00005145 glioblast semapv:crossSpeciesExactMatch CL:0000340 semapv:ManualMappingCuration -FBbt:00005146 neuroblast semapv:crossSpeciesExactMatch CL:0000338 semapv:ManualMappingCuration -FBbt:00005147 neuroglioblast semapv:crossSpeciesExactMatch CL:0000468 semapv:ManualMappingCuration -FBbt:00005149 ganglion mother cell semapv:crossSpeciesExactMatch CL:0000469 semapv:ManualMappingCuration -FBbt:00005169 trichogen cell semapv:crossSpeciesExactMatch CL:0000374 semapv:ManualMappingCuration -FBbt:00005171 tormogen cell semapv:crossSpeciesExactMatch CL:0000372 semapv:ManualMappingCuration -FBbt:00005173 thecogen cell semapv:crossSpeciesExactMatch CL:0000380 semapv:ManualMappingCuration -FBbt:00005219 scolopale cell semapv:crossSpeciesExactMatch CL:0000382 semapv:ManualMappingCuration -FBbt:00005221 scolopidial ligament cell semapv:crossSpeciesExactMatch CL:0000407 semapv:ManualMappingCuration -FBbt:00005412 gamete semapv:crossSpeciesExactMatch CL:0000300 semapv:ManualMappingCuration -FBbt:00005797 Malpighian tubule Type II cell semapv:crossSpeciesExactMatch CL:1000155 semapv:ManualMappingCuration -FBbt:00005812 myotube semapv:crossSpeciesExactMatch CL:0002372 semapv:ManualMappingCuration -FBbt:00005917 lymph gland derived hemocyte semapv:crossSpeciesExactMatch CL:0000735 semapv:ManualMappingCuration -FBbt:00006009 eye photoreceptor cell semapv:crossSpeciesExactMatch CL:2000019 semapv:ManualMappingCuration -FBbt:00007002 cell semapv:crossSpeciesExactMatch CL:0000000 semapv:ManualMappingCuration -FBbt:00007108 imaginal disc epithelial cell semapv:crossSpeciesExactMatch CL:0000429 semapv:ManualMappingCuration -FBbt:00007173 cholinergic neuron semapv:crossSpeciesExactMatch CL:0000108 semapv:ManualMappingCuration -FBbt:00007228 GABAergic neuron semapv:crossSpeciesExactMatch CL:0000617 semapv:ManualMappingCuration -FBbt:00007325 epidermal cell semapv:crossSpeciesExactMatch CL:0000463 semapv:ManualMappingCuration -FBbt:00007367 histaminergic neuron semapv:crossSpeciesExactMatch CL:0011110 semapv:ManualMappingCuration -FBbt:00048032 glycinergic neuron semapv:crossSpeciesExactMatch CL:1001509 semapv:ManualMappingCuration -FBbt:00057012 female germline cell semapv:crossSpeciesExactMatch CL:0000025 semapv:ManualMappingCuration -FBbt:00058020 juvenile hormone secreting cell semapv:crossSpeciesExactMatch CL:0000482 semapv:ManualMappingCuration -FBbt:00100291 glutamatergic neuron semapv:crossSpeciesExactMatch CL:0000679 semapv:ManualMappingCuration +subject_id subject_label predicate_id object_id object_label mapping_justification +FBbt:00000092 primordial germ cell semapv:crossSpeciesExactMatch CL:0000301 pole cell semapv:ManualMappingCuration +FBbt:00000124 epithelial cell semapv:crossSpeciesExactMatch CL:0000066 epithelial cell semapv:ManualMappingCuration +FBbt:00001666 cardioblast semapv:crossSpeciesExactMatch CL:0000465 cardioblast (sensu Arthropoda) semapv:ManualMappingCuration +FBbt:00001685 embryonic/larval plasmatocyte semapv:crossSpeciesExactMatch CL:0000394 plasmatocyte semapv:ManualMappingCuration +FBbt:00001687 lamellocyte semapv:crossSpeciesExactMatch CL:0000396 lamellocyte semapv:ManualMappingCuration +FBbt:00001689 procrystal cell semapv:crossSpeciesExactMatch CL:0000395 procrystal cell semapv:ManualMappingCuration +FBbt:00001690 embryonic/larval crystal cell semapv:crossSpeciesExactMatch CL:0000715 embryonic crystal cell semapv:ManualMappingCuration +FBbt:00001789 histoblast semapv:crossSpeciesExactMatch CL:0000373 histoblast semapv:ManualMappingCuration +FBbt:00003219 adepithelial cell semapv:crossSpeciesExactMatch CL:0000462 adepithelial cell semapv:ManualMappingCuration +FBbt:00003360 flight muscle cell semapv:crossSpeciesExactMatch CL:0000196 insect flight muscle cell semapv:ManualMappingCuration +FBbt:00003686 Kenyon cell semapv:crossSpeciesExactMatch CL:0000673 Kenyon cell semapv:ManualMappingCuration +FBbt:00004101 peptidergic neuron semapv:crossSpeciesExactMatch CL:0000110 peptidergic neuron semapv:ManualMappingCuration +FBbt:00004193 cone cell semapv:crossSpeciesExactMatch CL:0000718 compound eye cone cell semapv:ManualMappingCuration +FBbt:00004211 photoreceptor cell semapv:crossSpeciesExactMatch CL:0000210 photoreceptor cell semapv:ManualMappingCuration +FBbt:00004213 photoreceptor cell R1 semapv:crossSpeciesExactMatch CL:0000687 R1 photoreceptor cell semapv:ManualMappingCuration +FBbt:00004215 photoreceptor cell R2 semapv:crossSpeciesExactMatch CL:0000690 R2 photoreceptor cell semapv:ManualMappingCuration +FBbt:00004217 photoreceptor cell R3 semapv:crossSpeciesExactMatch CL:0000694 R3 photoreceptor cell semapv:ManualMappingCuration +FBbt:00004219 photoreceptor cell R4 semapv:crossSpeciesExactMatch CL:0000697 R4 photoreceptor cell semapv:ManualMappingCuration +FBbt:00004221 photoreceptor cell R5 semapv:crossSpeciesExactMatch CL:0000702 R5 photoreceptor cell semapv:ManualMappingCuration +FBbt:00004223 photoreceptor cell R6 semapv:crossSpeciesExactMatch CL:0000705 R6 photoreceptor cell semapv:ManualMappingCuration +FBbt:00004225 photoreceptor cell R7 semapv:crossSpeciesExactMatch CL:0000707 R7 photoreceptor cell semapv:ManualMappingCuration +FBbt:00004227 photoreceptor cell R8 semapv:crossSpeciesExactMatch CL:0000709 R8 photoreceptor cell semapv:ManualMappingCuration +FBbt:00004230 pigment cell semapv:crossSpeciesExactMatch CL:0001658 visual pigment cell (sensu Nematoda and Protostomia) semapv:ManualMappingCuration +FBbt:00004861 germline stem cell semapv:crossSpeciesExactMatch CL:0000014 germ line stem cell semapv:ManualMappingCuration +FBbt:00004873 female germline stem cell semapv:crossSpeciesExactMatch CL:0000022 female germ line stem cell semapv:ManualMappingCuration +FBbt:00004878 nurse cell semapv:crossSpeciesExactMatch CL:0000026 invertebrate nurse cell semapv:ManualMappingCuration +FBbt:00004886 oocyte semapv:crossSpeciesExactMatch CL:0000023 oocyte semapv:ManualMappingCuration +FBbt:00004903 follicle stem cell semapv:crossSpeciesExactMatch CL:0000441 follicle stem cell (sensu Arthropoda) semapv:ManualMappingCuration +FBbt:00004904 follicle cell semapv:crossSpeciesExactMatch CL:0000477 follicle cell of egg chamber semapv:ManualMappingCuration +FBbt:00004905 border follicle cell semapv:crossSpeciesExactMatch CL:0000579 border follicle cell semapv:ManualMappingCuration +FBbt:00004906 centripetal follicle cell semapv:crossSpeciesExactMatch CL:0000671 centripetally migrating follicle cell semapv:ManualMappingCuration +FBbt:00004910 stalk follicle cell semapv:crossSpeciesExactMatch CL:0000674 interfollicle cell semapv:ManualMappingCuration +FBbt:00004929 male germline stem cell semapv:crossSpeciesExactMatch CL:0000016 male germ line stem cell semapv:ManualMappingCuration +FBbt:00004934 primary gonial cell semapv:crossSpeciesExactMatch CL:0000020 spermatogonium semapv:ManualMappingCuration +FBbt:00004935 spermatogonium semapv:crossSpeciesExactMatch CL:0000020 spermatogonium semapv:ManualMappingCuration +FBbt:00004936 spermatocyte semapv:crossSpeciesExactMatch CL:0000017 spermatocyte semapv:ManualMappingCuration +FBbt:00004941 secondary spermatocyte semapv:crossSpeciesExactMatch CL:0000657 secondary spermatocyte semapv:ManualMappingCuration +FBbt:00004942 spermatid semapv:crossSpeciesExactMatch CL:0000018 spermatid semapv:ManualMappingCuration +FBbt:00004954 spermatozoon semapv:crossSpeciesExactMatch CL:0000019 sperm semapv:ManualMappingCuration +FBbt:00004994 epidermoblast semapv:crossSpeciesExactMatch CL:0000464 epidermoblast semapv:ManualMappingCuration +FBbt:00004995 oenocyte semapv:crossSpeciesExactMatch CL:0000487 oenocyte semapv:ManualMappingCuration +FBbt:00005038 tracheocyte semapv:crossSpeciesExactMatch CL:0008026 open tracheal system tracheocyte semapv:ManualMappingCuration +FBbt:00005058 pericardial cell semapv:crossSpeciesExactMatch CL:0000474 pericardial nephrocyte semapv:ManualMappingCuration +FBbt:00005059 garland cell semapv:crossSpeciesExactMatch CL:0000486 garland cell semapv:ManualMappingCuration +FBbt:00005062 prohemocyte semapv:crossSpeciesExactMatch CL:0000385 prohemocyte (sensu Nematoda and Protostomia) semapv:ManualMappingCuration +FBbt:00005063 hemocyte semapv:crossSpeciesExactMatch CL:0000387 hemocyte (sensu Arthropoda) semapv:ManualMappingCuration +FBbt:00005070 visceral muscle cell semapv:crossSpeciesExactMatch CL:0008007 visceral muscle cell semapv:ManualMappingCuration +FBbt:00005073 somatic muscle cell semapv:crossSpeciesExactMatch CL:0008004 somatic muscle cell semapv:ManualMappingCuration +FBbt:00005074 muscle cell semapv:crossSpeciesExactMatch CL:0000187 muscle cell semapv:ManualMappingCuration +FBbt:00005083 myoblast semapv:crossSpeciesExactMatch CL:0000056 myoblast semapv:ManualMappingCuration +FBbt:00005106 neuron semapv:crossSpeciesExactMatch CL:0000540 neuron semapv:ManualMappingCuration +FBbt:00005123 motor neuron semapv:crossSpeciesExactMatch CL:0000100 motor neuron semapv:ManualMappingCuration +FBbt:00005124 sensory neuron semapv:crossSpeciesExactMatch CL:0000101 sensory neuron semapv:ManualMappingCuration +FBbt:00005125 interneuron semapv:crossSpeciesExactMatch CL:0000099 interneuron semapv:ManualMappingCuration +FBbt:00005128 pioneer neuron semapv:crossSpeciesExactMatch CL:0000116 pioneer neuron semapv:ManualMappingCuration +FBbt:00005130 neurosecretory neuron semapv:crossSpeciesExactMatch CL:0000165 neuroendocrine cell semapv:ManualMappingCuration +FBbt:00005131 dopaminergic neuron semapv:crossSpeciesExactMatch CL:0000700 dopaminergic neuron semapv:ManualMappingCuration +FBbt:00005133 serotonergic neuron semapv:crossSpeciesExactMatch CL:0000850 serotonergic neuron semapv:ManualMappingCuration +FBbt:00005144 glial cell semapv:crossSpeciesExactMatch CL:0000125 glial cell semapv:ManualMappingCuration +FBbt:00005145 glioblast semapv:crossSpeciesExactMatch CL:0000340 glioblast (sensu Nematoda and Protostomia) semapv:ManualMappingCuration +FBbt:00005146 neuroblast semapv:crossSpeciesExactMatch CL:0000338 neuroblast (sensu Nematoda and Protostomia) semapv:ManualMappingCuration +FBbt:00005147 neuroglioblast semapv:crossSpeciesExactMatch CL:0000468 neuroglioblast (sensu Nematoda and Protostomia) semapv:ManualMappingCuration +FBbt:00005149 ganglion mother cell semapv:crossSpeciesExactMatch CL:0000469 ganglion mother cell semapv:ManualMappingCuration +FBbt:00005169 trichogen cell semapv:crossSpeciesExactMatch CL:0000374 trichogen cell semapv:ManualMappingCuration +FBbt:00005171 tormogen cell semapv:crossSpeciesExactMatch CL:0000372 tormogen cell semapv:ManualMappingCuration +FBbt:00005173 thecogen cell semapv:crossSpeciesExactMatch CL:0000380 thecogen cell semapv:ManualMappingCuration +FBbt:00005219 scolopale cell semapv:crossSpeciesExactMatch CL:0000382 scolopale cell semapv:ManualMappingCuration +FBbt:00005221 scolopidial ligament cell semapv:crossSpeciesExactMatch CL:0000407 scolopidial ligament cell semapv:ManualMappingCuration +FBbt:00005412 gamete semapv:crossSpeciesExactMatch CL:0000300 gamete semapv:ManualMappingCuration +FBbt:00005797 Malpighian tubule Type II cell semapv:crossSpeciesExactMatch CL:1000155 Malpighian tubule stellate cell semapv:ManualMappingCuration +FBbt:00005812 myotube semapv:crossSpeciesExactMatch CL:0002372 myotube semapv:ManualMappingCuration +FBbt:00005917 lymph gland derived hemocyte semapv:crossSpeciesExactMatch CL:0000735 lymph gland hemocyte semapv:ManualMappingCuration +FBbt:00006009 eye photoreceptor cell semapv:crossSpeciesExactMatch CL:2000019 compound eye photoreceptor cell semapv:ManualMappingCuration +FBbt:00007002 cell semapv:crossSpeciesExactMatch CL:0000000 cell semapv:ManualMappingCuration +FBbt:00007108 imaginal disc epithelial cell semapv:crossSpeciesExactMatch CL:0000429 imaginal disc cell semapv:ManualMappingCuration +FBbt:00007173 cholinergic neuron semapv:crossSpeciesExactMatch CL:0000108 cholinergic neuron semapv:ManualMappingCuration +FBbt:00007228 GABAergic neuron semapv:crossSpeciesExactMatch CL:0000617 GABAergic neuron semapv:ManualMappingCuration +FBbt:00007325 epidermal cell semapv:crossSpeciesExactMatch CL:0000463 epidermal cell (sensu Arthropoda) semapv:ManualMappingCuration +FBbt:00007367 histaminergic neuron semapv:crossSpeciesExactMatch CL:0011110 histaminergic neuron semapv:ManualMappingCuration +FBbt:00048032 glycinergic neuron semapv:crossSpeciesExactMatch CL:1001509 glycinergic neuron semapv:ManualMappingCuration +FBbt:00057012 female germline cell semapv:crossSpeciesExactMatch CL:0000025 egg cell semapv:ManualMappingCuration +FBbt:00058020 juvenile hormone secreting cell semapv:crossSpeciesExactMatch CL:0000482 juvenile hormone secreting cell semapv:ManualMappingCuration +FBbt:00100291 glutamatergic neuron semapv:crossSpeciesExactMatch CL:0000679 glutamatergic neuron semapv:ManualMappingCuration diff --git a/src/mappings/zfa.sssom.tsv b/src/mappings/zfa.sssom.tsv index 6c8f79183..4b142d1ee 100644 --- a/src/mappings/zfa.sssom.tsv +++ b/src/mappings/zfa.sssom.tsv @@ -4,442 +4,430 @@ #mapping_set_id: "http://purl.obolibrary.org/obo/zfa/zfa.sssom.tsv" #license: "https://creativecommons.org/licenses/by/3.0/" #subject_source: "http://purl.obolibrary.org/obo/zfa.owl" -subject_id subject_label predicate_id object_id mapping_justification mapping_cardinality -ZFA:0000003 adaxial cell semapv:crossSpeciesExactMatch CL:0007016 semapv:UnspecifiedMatching 1:1 -ZFA:0000084 yolk semapv:crossSpeciesExactMatch CL:0000428 semapv:UnspecifiedMatching 1:1 -ZFA:0000778 spinal cord interneuron semapv:crossSpeciesExactMatch CL:0005000 semapv:UnspecifiedMatching 1:1 -ZFA:0001109 oocyte semapv:crossSpeciesExactMatch CL:0000023 semapv:UnspecifiedMatching 1:1 -ZFA:0001570 unfertilized egg semapv:crossSpeciesExactMatch CL:0000025 semapv:UnspecifiedMatching 1:1 -ZFA:0001691 cerebellar granule cell semapv:crossSpeciesExactMatch CL:0001031 semapv:UnspecifiedMatching 1:1 -ZFA:0001694 olfactory granule cell semapv:crossSpeciesExactMatch CL:0000626 semapv:UnspecifiedMatching 1:1 -ZFA:0001725 immature Schwann cell semapv:crossSpeciesExactMatch CL:0002377 semapv:UnspecifiedMatching 1:1 -ZFA:0005236 basophilic erythroblast semapv:crossSpeciesExactMatch CL:0000549 semapv:UnspecifiedMatching 1:1 -ZFA:0005237 erythroblast semapv:crossSpeciesExactMatch CL:0000765 semapv:UnspecifiedMatching 1:1 -ZFA:0005238 juxtaglomerular cell semapv:crossSpeciesExactMatch CL:0000648 semapv:UnspecifiedMatching 1:1 -ZFA:0005239 micropylar cell semapv:crossSpeciesExactMatch CL:0007022 semapv:UnspecifiedMatching 1:1 -ZFA:0005240 Kolmer-Agduhr neuron semapv:crossSpeciesExactMatch CL:0005007 semapv:UnspecifiedMatching 1:1 -ZFA:0005241 polychromatophilic erythroblast semapv:crossSpeciesExactMatch CL:0000550 semapv:UnspecifiedMatching 1:1 -ZFA:0005242 multi-ciliated epithelial cell semapv:crossSpeciesExactMatch CL:0005012 semapv:UnspecifiedMatching 1:1 -ZFA:0005243 single ciliated epithelial cell semapv:crossSpeciesExactMatch CL:0005013 semapv:UnspecifiedMatching 1:1 -ZFA:0005244 auditory epithelial support cell semapv:crossSpeciesExactMatch CL:0005014 semapv:UnspecifiedMatching 1:1 -ZFA:0005245 xanthoblast semapv:crossSpeciesExactMatch CL:0005002 semapv:UnspecifiedMatching 1:1 -ZFA:0005322 renal principal cell semapv:crossSpeciesExactMatch CL:0005009 semapv:UnspecifiedMatching 1:1 -ZFA:0005323 ionocyte semapv:crossSpeciesExactMatch CL:0005006 semapv:UnspecifiedMatching 1:1 -ZFA:0005328 iridoblast semapv:crossSpeciesExactMatch CL:0005001 semapv:UnspecifiedMatching 1:1 -ZFA:0005329 leucoblast semapv:crossSpeciesExactMatch CL:0005003 semapv:UnspecifiedMatching 1:1 -ZFA:0005331 pigment erythroblast semapv:crossSpeciesExactMatch CL:0005004 semapv:UnspecifiedMatching 1:1 -ZFA:0005332 cyanoblast semapv:crossSpeciesExactMatch CL:0005005 semapv:UnspecifiedMatching 1:1 -ZFA:0005565 tether cell semapv:crossSpeciesExactMatch CL:0002450 semapv:UnspecifiedMatching 1:1 -ZFA:0005598 pancreatic epsilon cell semapv:crossSpeciesExactMatch CL:0005019 semapv:UnspecifiedMatching 1:1 -ZFA:0005599 ghrelin secreting cell semapv:crossSpeciesExactMatch CL:0005018 semapv:UnspecifiedMatching 1:1 -ZFA:0005730 cranial motor neuron semapv:crossSpeciesExactMatch CL:0015000 semapv:UnspecifiedMatching 1:1 -ZFA:0005731 branchiomotor neuron semapv:crossSpeciesExactMatch CL:0005023 semapv:UnspecifiedMatching 1:1 -ZFA:0005732 visceromotor neuron semapv:crossSpeciesExactMatch CL:0005025 semapv:UnspecifiedMatching 1:1 -ZFA:0005733 somatomotor neuron semapv:crossSpeciesExactMatch CL:0005024 semapv:UnspecifiedMatching 1:1 -ZFA:0005739 pancreatic acinar cell semapv:crossSpeciesExactMatch CL:0002064 semapv:UnspecifiedMatching 1:1 -ZFA:0005740 pancreatic centroacinar cell semapv:crossSpeciesExactMatch CL:0002080 semapv:UnspecifiedMatching 1:1 -ZFA:0005742 pancreatic PP cell semapv:crossSpeciesExactMatch CL:0002275 semapv:UnspecifiedMatching 1:1 -ZFA:0005743 pancreatic D cell semapv:crossSpeciesExactMatch CL:0000173 semapv:UnspecifiedMatching 1:1 -ZFA:0005744 notochord outer sheath cell semapv:crossSpeciesExactMatch CL:0007007 semapv:UnspecifiedMatching 1:1 -ZFA:0005745 structural cell semapv:crossSpeciesExactMatch CL:0000293 semapv:UnspecifiedMatching 1:1 -ZFA:0005769 spermatid semapv:crossSpeciesExactMatch CL:0000018 semapv:UnspecifiedMatching 1:1 -ZFA:0005772 fertilized egg semapv:crossSpeciesExactMatch CL:00000365 semapv:UnspecifiedMatching 1:1 -ZFA:0005773 embryonic blood vessel endothelial progenitor cell semapv:crossSpeciesExactMatch CL:0002546 semapv:UnspecifiedMatching 1:1 -ZFA:0005775 enteric neuron semapv:crossSpeciesExactMatch CL:0007011 semapv:UnspecifiedMatching 1:1 -ZFA:0005776 parasympathetic neuron semapv:crossSpeciesExactMatch CL:0011102 semapv:UnspecifiedMatching 1:1 -ZFA:0005777 sympathetic neuron semapv:crossSpeciesExactMatch CL:0011103 semapv:UnspecifiedMatching 1:1 -ZFA:0005778 hypocretin-secreting neuron semapv:crossSpeciesExactMatch CL:0011109 semapv:UnspecifiedMatching 1:1 -ZFA:0005784 striated muscle cell semapv:crossSpeciesExactMatch CL:0000737 semapv:UnspecifiedMatching 1:1 -ZFA:0005830 hematopoietic cell semapv:crossSpeciesExactMatch CL:0000988 semapv:UnspecifiedMatching 1:1 -ZFA:0005873 noradrenergic neuron semapv:crossSpeciesExactMatch CL:0008025 semapv:UnspecifiedMatching 1:1 -ZFA:0005878 oogonia semapv:crossSpeciesExactMatch CL:0000024 semapv:UnspecifiedMatching 1:1 -ZFA:0005944 mural cell semapv:crossSpeciesExactMatch CL:0008034 semapv:UnspecifiedMatching 1:1 -ZFA:0005956 germline stem cell semapv:crossSpeciesExactMatch CL:0000014 semapv:UnspecifiedMatching 1:1 -ZFA:0005957 stem cell semapv:crossSpeciesExactMatch CL:0000034 semapv:UnspecifiedMatching 1:1 -ZFA:0007084 premigratory neural crest cell semapv:crossSpeciesExactMatch CL:0007004 semapv:UnspecifiedMatching 1:1 -ZFA:0007086 migratory neural crest cell semapv:crossSpeciesExactMatch CL:0000333 semapv:UnspecifiedMatching 1:1 -ZFA:0007089 embryonic cell semapv:crossSpeciesExactMatch CL:0002321 semapv:UnspecifiedMatching 1:1 -ZFA:0007091 migratory cranial neural crest cell semapv:crossSpeciesExactMatch CL:0000008 semapv:UnspecifiedMatching 1:1 -ZFA:0007095 migratory trunk neural crest cell semapv:crossSpeciesExactMatch CL:0000011 semapv:UnspecifiedMatching 1:1 -ZFA:0007122 epidermal stem cell semapv:crossSpeciesExactMatch CL:1000428 semapv:UnspecifiedMatching 1:1 -ZFA:0009000 cell semapv:crossSpeciesExactMatch CL:0000000 semapv:UnspecifiedMatching 1:1 -ZFA:0009001 receptor cell (sensu Animalia) semapv:crossSpeciesExactMatch CL:0000006 semapv:UnspecifiedMatching 1:1 -ZFA:0009002 early embryonic cell semapv:crossSpeciesExactMatch CL:0000007 semapv:UnspecifiedMatching 1:1 -ZFA:0009005 spermatocyte semapv:crossSpeciesExactMatch CL:0000017 semapv:UnspecifiedMatching 1:1 -ZFA:0009006 sperm semapv:crossSpeciesExactMatch CL:0000019 semapv:UnspecifiedMatching 1:1 -ZFA:0009007 spermatogonium semapv:crossSpeciesExactMatch CL:0000020 semapv:UnspecifiedMatching 1:1 -ZFA:0009009 neuron neural crest derived semapv:crossSpeciesExactMatch CL:0000029 semapv:UnspecifiedMatching 1:1 -ZFA:0009010 glioblast semapv:crossSpeciesExactMatch CL:0000030 semapv:UnspecifiedMatching 1:1 -ZFA:0009011 neuroblast semapv:crossSpeciesExactMatch CL:0000031 semapv:UnspecifiedMatching 1:1 -ZFA:0009012 neuroplacodal cell semapv:crossSpeciesExactMatch CL:0000032 semapv:UnspecifiedMatching 1:1 -ZFA:0009013 single fate stem cell semapv:crossSpeciesExactMatch CL:0000035 semapv:UnspecifiedMatching 1:1 -ZFA:0009014 hematopoietic stem cell semapv:crossSpeciesExactMatch CL:0000037 semapv:UnspecifiedMatching 1:1 -ZFA:0009015 erythroid progenitor cell semapv:crossSpeciesExactMatch CL:0000038 semapv:UnspecifiedMatching 1:1 -ZFA:0009016 germ line cell semapv:crossSpeciesExactMatch CL:0000039 semapv:UnspecifiedMatching 1:1 -ZFA:0009017 monoblast semapv:crossSpeciesExactMatch CL:0000040 semapv:UnspecifiedMatching 1:1 -ZFA:0009018 neutrophilic myeloblast semapv:crossSpeciesExactMatch CL:0000042 semapv:UnspecifiedMatching 1:1 -ZFA:0009019 neuronal stem cell semapv:crossSpeciesExactMatch CL:0000047 semapv:UnspecifiedMatching 1:1 -ZFA:0009020 multi fate stem cell semapv:crossSpeciesExactMatch CL:0000048 semapv:UnspecifiedMatching 1:1 -ZFA:0009021 common myeloid progenitor semapv:crossSpeciesExactMatch CL:0000049 semapv:UnspecifiedMatching 1:1 -ZFA:0009022 megakaryocyte erythroid progenitor cell semapv:crossSpeciesExactMatch CL:0000050 semapv:UnspecifiedMatching 1:1 -ZFA:0009023 common lymphoid progenitor semapv:crossSpeciesExactMatch CL:0000051 semapv:UnspecifiedMatching 1:1 -ZFA:0009024 totipotent stem cell semapv:crossSpeciesExactMatch CL:0000052 semapv:UnspecifiedMatching 1:1 -ZFA:0009025 myoblast semapv:crossSpeciesExactMatch CL:0000056 semapv:UnspecifiedMatching 1:1 -ZFA:0009026 fibroblast semapv:crossSpeciesExactMatch CL:0000057 semapv:UnspecifiedMatching 1:1 -ZFA:0009027 chondroblast semapv:crossSpeciesExactMatch CL:0000058 semapv:UnspecifiedMatching 1:1 -ZFA:0009029 odontoblast semapv:crossSpeciesExactMatch CL:0000060 semapv:UnspecifiedMatching 1:1 -ZFA:0009030 cementoblast semapv:crossSpeciesExactMatch CL:0000061 semapv:UnspecifiedMatching 1:1 -ZFA:0009031 osteoblast semapv:crossSpeciesExactMatch CL:0000062 semapv:UnspecifiedMatching 1:1 -ZFA:0009032 ciliated cell semapv:crossSpeciesExactMatch CL:0000064 semapv:UnspecifiedMatching 1:1 -ZFA:0009033 ependymal cell semapv:crossSpeciesExactMatch CL:0000065 semapv:UnspecifiedMatching 1:1 -ZFA:0009034 epithelial cell semapv:crossSpeciesExactMatch CL:0000066 semapv:UnspecifiedMatching 1:1 -ZFA:0009035 ciliated epithelial cell semapv:crossSpeciesExactMatch CL:0000067 semapv:UnspecifiedMatching 1:1 -ZFA:0009036 blood vessel endothelial cell semapv:crossSpeciesExactMatch CL:0000071 semapv:UnspecifiedMatching 1:1 -ZFA:0009037 barrier epithelial cell semapv:crossSpeciesExactMatch CL:0000073 semapv:UnspecifiedMatching 1:1 -ZFA:0009038 columnar/cuboidal epithelial cell semapv:crossSpeciesExactMatch CL:0000075 semapv:UnspecifiedMatching 1:1 -ZFA:0009039 squamous epithelial cell semapv:crossSpeciesExactMatch CL:0000076 semapv:UnspecifiedMatching 1:1 -ZFA:0009040 mesothelial cell semapv:crossSpeciesExactMatch CL:0000077 semapv:UnspecifiedMatching 1:1 -ZFA:0009041 peridermal cell semapv:crossSpeciesExactMatch CL:0000078 semapv:UnspecifiedMatching 1:1 -ZFA:0009042 stratified epithelial cell semapv:crossSpeciesExactMatch CL:0000079 semapv:UnspecifiedMatching 1:1 -ZFA:0009043 circulating cell semapv:crossSpeciesExactMatch CL:0000080 semapv:UnspecifiedMatching 1:1 -ZFA:0009044 blood cell semapv:crossSpeciesExactMatch CL:0000081 semapv:UnspecifiedMatching 1:1 -ZFA:0009045 epithelial cell of pancreas semapv:crossSpeciesExactMatch CL:0000083 semapv:UnspecifiedMatching 1:1 -ZFA:0009046 T cell semapv:crossSpeciesExactMatch CL:0000084 semapv:UnspecifiedMatching 1:1 -ZFA:0009047 osteoclast semapv:crossSpeciesExactMatch CL:0000092 semapv:UnspecifiedMatching 1:1 -ZFA:0009048 granulocyte semapv:crossSpeciesExactMatch CL:0000094 semapv:UnspecifiedMatching 1:1 -ZFA:0009049 mature neutrophil semapv:crossSpeciesExactMatch CL:0000096 semapv:UnspecifiedMatching 1:1 -ZFA:0009050 sensory epithelial cell semapv:crossSpeciesExactMatch CL:0000098 semapv:UnspecifiedMatching 1:1 -ZFA:0009051 interneuron semapv:crossSpeciesExactMatch CL:0000099 semapv:UnspecifiedMatching 1:1 -ZFA:0009052 motor neuron semapv:crossSpeciesExactMatch CL:0000100 semapv:UnspecifiedMatching 1:1 -ZFA:0009053 sensory neuron semapv:crossSpeciesExactMatch CL:0000101 semapv:UnspecifiedMatching 1:1 -ZFA:0009054 polymodal neuron semapv:crossSpeciesExactMatch CL:0000102 semapv:UnspecifiedMatching 1:1 -ZFA:0009055 bipolar neuron semapv:crossSpeciesExactMatch CL:0000103 semapv:UnspecifiedMatching 1:1 -ZFA:0009056 multipolar neuron semapv:crossSpeciesExactMatch CL:0000104 semapv:UnspecifiedMatching 1:1 -ZFA:0009057 pseudounipolar neuron semapv:crossSpeciesExactMatch CL:0000105 semapv:UnspecifiedMatching 1:1 -ZFA:0009058 unipolar neuron semapv:crossSpeciesExactMatch CL:0000106 semapv:UnspecifiedMatching 1:1 -ZFA:0009059 autonomic neuron semapv:crossSpeciesExactMatch CL:0000107 semapv:UnspecifiedMatching 1:1 -ZFA:0009060 cholinergic neuron semapv:crossSpeciesExactMatch CL:0000108 semapv:UnspecifiedMatching 1:1 -ZFA:0009061 adrenergic neuron semapv:crossSpeciesExactMatch CL:0000109 semapv:UnspecifiedMatching 1:1 -ZFA:0009062 peptidergic neuron semapv:crossSpeciesExactMatch CL:0000110 semapv:UnspecifiedMatching 1:1 -ZFA:0009063 peripheral neuron semapv:crossSpeciesExactMatch CL:0000111 semapv:UnspecifiedMatching 1:1 -ZFA:0009064 mononuclear phagocyte semapv:crossSpeciesExactMatch CL:0000113 semapv:UnspecifiedMatching 1:1 -ZFA:0009065 endothelial cell semapv:crossSpeciesExactMatch CL:0000115 semapv:UnspecifiedMatching 1:1 -ZFA:0009066 pioneer neuron semapv:crossSpeciesExactMatch CL:0000116 semapv:UnspecifiedMatching 1:1 -ZFA:0009067 CNS neuron (sensu Vertebrata) semapv:crossSpeciesExactMatch CL:0000117 semapv:UnspecifiedMatching 1:1 -ZFA:0009068 basket cell semapv:crossSpeciesExactMatch CL:0000118 semapv:UnspecifiedMatching 1:1 -ZFA:0009069 Golgi cell semapv:crossSpeciesExactMatch CL:0000119 semapv:UnspecifiedMatching 1:1 -ZFA:0009070 granule cell semapv:crossSpeciesExactMatch CL:0000120 semapv:UnspecifiedMatching 1:1 -ZFA:0009071 Purkinje cell semapv:crossSpeciesExactMatch CL:0000121 semapv:UnspecifiedMatching 1:1 -ZFA:0009072 stellate cell semapv:crossSpeciesExactMatch CL:0000122 semapv:UnspecifiedMatching 1:1 -ZFA:0009073 glial cell semapv:crossSpeciesExactMatch CL:0000125 semapv:UnspecifiedMatching 1:1 -ZFA:0009074 macroglial cell semapv:crossSpeciesExactMatch CL:0000126 semapv:UnspecifiedMatching 1:1 -ZFA:0009075 astrocyte semapv:crossSpeciesExactMatch CL:0000127 semapv:UnspecifiedMatching 1:1 -ZFA:0009076 oligodendrocyte semapv:crossSpeciesExactMatch CL:0000128 semapv:UnspecifiedMatching 1:1 -ZFA:0009077 microglial cell semapv:crossSpeciesExactMatch CL:0000129 semapv:UnspecifiedMatching 1:1 -ZFA:0009078 gut endothelial cell semapv:crossSpeciesExactMatch CL:0000131 semapv:UnspecifiedMatching 1:1 -ZFA:0009079 corneal endothelial cell semapv:crossSpeciesExactMatch CL:0000132 semapv:UnspecifiedMatching 1:1 -ZFA:0009080 neurectodermal cell semapv:crossSpeciesExactMatch CL:0000133 semapv:UnspecifiedMatching 1:1 -ZFA:0009081 mesenchymal cell semapv:crossSpeciesExactMatch CL:0000134 semapv:UnspecifiedMatching 1:1 -ZFA:0009082 fat cell semapv:crossSpeciesExactMatch CL:0000136 semapv:UnspecifiedMatching 1:n -ZFA:0009082 fat cell semapv:crossSpeciesExactMatch CL:0000450 semapv:UnspecifiedMatching 1:n -ZFA:0009083 osteocyte semapv:crossSpeciesExactMatch CL:0000137 semapv:UnspecifiedMatching 1:1 -ZFA:0009084 chondrocyte semapv:crossSpeciesExactMatch CL:0000138 semapv:UnspecifiedMatching 1:1 -ZFA:0009086 odontocyte semapv:crossSpeciesExactMatch CL:0000140 semapv:UnspecifiedMatching 1:1 -ZFA:0009087 cementocyte semapv:crossSpeciesExactMatch CL:0000141 semapv:UnspecifiedMatching 1:1 -ZFA:0009088 professional antigen presenting cell semapv:crossSpeciesExactMatch CL:0000145 semapv:UnspecifiedMatching 1:1 -ZFA:0009089 simple columnar epithelial cell semapv:crossSpeciesExactMatch CL:0000146 semapv:UnspecifiedMatching 1:1 -ZFA:0009090 pigment cell semapv:crossSpeciesExactMatch CL:0000147 semapv:UnspecifiedMatching 1:1 -ZFA:0009091 melanocyte semapv:crossSpeciesExactMatch CL:0000148 semapv:UnspecifiedMatching 1:1 -ZFA:0009092 exocrine cell semapv:crossSpeciesExactMatch CL:0000152 semapv:UnspecifiedMatching 1:1 -ZFA:0009093 GAG secreting cell semapv:crossSpeciesExactMatch CL:0000153 semapv:UnspecifiedMatching 1:1 -ZFA:0009094 goblet cell semapv:crossSpeciesExactMatch CL:0000160 semapv:UnspecifiedMatching 1:1 -ZFA:0009095 acid secreting cell semapv:crossSpeciesExactMatch CL:0000161 semapv:UnspecifiedMatching 1:1 -ZFA:0009096 endocrine cell semapv:crossSpeciesExactMatch CL:0000163 semapv:UnspecifiedMatching 1:1 -ZFA:0009097 enteroendocrine cell semapv:crossSpeciesExactMatch CL:0000164 semapv:UnspecifiedMatching 1:1 -ZFA:0009098 neuroendocrine cell semapv:crossSpeciesExactMatch CL:0000165 semapv:UnspecifiedMatching 1:1 -ZFA:0009099 chromaffin cell semapv:crossSpeciesExactMatch CL:0000166 semapv:UnspecifiedMatching 1:1 -ZFA:0009100 peptide hormone secreting cell semapv:crossSpeciesExactMatch CL:0000167 semapv:UnspecifiedMatching 1:1 -ZFA:0009101 insulin secreting cell semapv:crossSpeciesExactMatch CL:0000168 semapv:UnspecifiedMatching 1:1 -ZFA:0009102 pancreatic B cell semapv:crossSpeciesExactMatch CL:0000169 semapv:UnspecifiedMatching 1:1 -ZFA:0009103 glucagon secreting cell semapv:crossSpeciesExactMatch CL:0000170 semapv:UnspecifiedMatching 1:1 -ZFA:0009104 pancreatic A cell semapv:crossSpeciesExactMatch CL:0000171 semapv:UnspecifiedMatching 1:1 -ZFA:0009105 somatostatin secreting cell semapv:crossSpeciesExactMatch CL:0000172 semapv:UnspecifiedMatching 1:1 -ZFA:0009106 steroid hormone secreting cell semapv:crossSpeciesExactMatch CL:0000174 semapv:UnspecifiedMatching 1:1 -ZFA:0009107 testosterone secreting cell semapv:crossSpeciesExactMatch CL:0000177 semapv:UnspecifiedMatching 1:1 -ZFA:0009108 Leydig cell semapv:crossSpeciesExactMatch CL:0000178 semapv:UnspecifiedMatching 1:1 -ZFA:0009109 progesterone secreting cell semapv:crossSpeciesExactMatch CL:0000179 semapv:UnspecifiedMatching 1:1 -ZFA:0009110 estradiol secreting cell semapv:crossSpeciesExactMatch CL:0000180 semapv:UnspecifiedMatching 1:1 -ZFA:0009111 hepatocyte semapv:crossSpeciesExactMatch CL:0000182 semapv:UnspecifiedMatching 1:1 -ZFA:0009112 pericyte semapv:crossSpeciesExactMatch CL:0000669 semapv:UnspecifiedMatching 1:1 -ZFA:0009113 myoepithelial cell semapv:crossSpeciesExactMatch CL:0000185 semapv:UnspecifiedMatching 1:1 -ZFA:0009114 muscle cell semapv:crossSpeciesExactMatch CL:0000187 semapv:UnspecifiedMatching 1:1 -ZFA:0009115 skeletal muscle cell semapv:crossSpeciesExactMatch CL:0000188 semapv:UnspecifiedMatching 1:1 -ZFA:0009116 slow muscle cell semapv:crossSpeciesExactMatch CL:0000189 semapv:UnspecifiedMatching 1:1 -ZFA:0009117 fast muscle cell semapv:crossSpeciesExactMatch CL:0000190 semapv:UnspecifiedMatching 1:1 -ZFA:0009118 smooth muscle cell semapv:crossSpeciesExactMatch CL:0000192 semapv:UnspecifiedMatching 1:1 -ZFA:0009119 pain receptor cell semapv:crossSpeciesExactMatch CL:0000198 semapv:UnspecifiedMatching 1:1 -ZFA:0009120 mechanoreceptor cell semapv:crossSpeciesExactMatch CL:0000199 semapv:UnspecifiedMatching 1:1 -ZFA:0009121 auditory receptor cell semapv:crossSpeciesExactMatch CL:0000202 semapv:UnspecifiedMatching 1:1 -ZFA:0009123 thermoreceptor cell semapv:crossSpeciesExactMatch CL:0000205 semapv:UnspecifiedMatching 1:1 -ZFA:0009124 chemoreceptor cell semapv:crossSpeciesExactMatch CL:0000206 semapv:UnspecifiedMatching 1:1 -ZFA:0009125 olfactory receptor cell semapv:crossSpeciesExactMatch CL:0000207 semapv:UnspecifiedMatching 1:1 -ZFA:0009126 taste receptor cell semapv:crossSpeciesExactMatch CL:0000209 semapv:UnspecifiedMatching 1:1 -ZFA:0009127 photoreceptor cell semapv:crossSpeciesExactMatch CL:0000210 semapv:UnspecifiedMatching 1:1 -ZFA:0009128 electrically active cell semapv:crossSpeciesExactMatch CL:0000211 semapv:UnspecifiedMatching 1:1 -ZFA:0009129 absorptive cell semapv:crossSpeciesExactMatch CL:0000212 semapv:UnspecifiedMatching 1:1 -ZFA:0009130 lining cell semapv:crossSpeciesExactMatch CL:0000213 semapv:UnspecifiedMatching 1:1 -ZFA:0009131 synovial cell semapv:crossSpeciesExactMatch CL:0000214 semapv:UnspecifiedMatching 1:1 -ZFA:0009132 barrier cell semapv:crossSpeciesExactMatch CL:0000215 semapv:UnspecifiedMatching 1:1 -ZFA:0009133 Sertoli cell semapv:crossSpeciesExactMatch CL:0000216 semapv:UnspecifiedMatching 1:1 -ZFA:0009134 insulating cell semapv:crossSpeciesExactMatch CL:0000217 semapv:UnspecifiedMatching 1:1 -ZFA:0009135 myelinating Schwann cell semapv:crossSpeciesExactMatch CL:0000218 semapv:UnspecifiedMatching 1:1 -ZFA:0009136 motile cell semapv:crossSpeciesExactMatch CL:0000219 semapv:UnspecifiedMatching 1:1 -ZFA:0009137 ectodermal cell semapv:crossSpeciesExactMatch CL:0000221 semapv:UnspecifiedMatching 1:1 -ZFA:0009138 mesodermal cell semapv:crossSpeciesExactMatch CL:0000222 semapv:UnspecifiedMatching 1:1 -ZFA:0009139 endodermal cell semapv:crossSpeciesExactMatch CL:0000223 semapv:UnspecifiedMatching 1:1 -ZFA:0009140 phagocyte semapv:crossSpeciesExactMatch CL:0000234 semapv:UnspecifiedMatching 1:1 -ZFA:0009141 macrophage semapv:crossSpeciesExactMatch CL:0000235 semapv:UnspecifiedMatching 1:1 -ZFA:0009142 B cell semapv:crossSpeciesExactMatch CL:0000236 semapv:UnspecifiedMatching 1:1 -ZFA:0009143 brush border epithelial cell semapv:crossSpeciesExactMatch CL:0000239 semapv:UnspecifiedMatching 1:1 -ZFA:0009144 stratified squamous epithelial cell semapv:crossSpeciesExactMatch CL:0000240 semapv:UnspecifiedMatching 1:1 -ZFA:0009145 stratified cuboidal epithelial cell semapv:crossSpeciesExactMatch CL:0000241 semapv:UnspecifiedMatching 1:1 -ZFA:0009146 Merkel cell semapv:crossSpeciesExactMatch CL:0000242 semapv:UnspecifiedMatching 1:1 -ZFA:0009147 glial cell (sensu Vertebrata) semapv:crossSpeciesExactMatch CL:0000243 semapv:UnspecifiedMatching 1:1 -ZFA:0009148 transitional epithelial cell semapv:crossSpeciesExactMatch CL:0000244 semapv:UnspecifiedMatching 1:1 -ZFA:0009149 Mauthner neuron semapv:crossSpeciesExactMatch CL:0000246 semapv:UnspecifiedMatching 1:1 -ZFA:0009150 Rohon-Beard neuron semapv:crossSpeciesExactMatch CL:0000247 semapv:UnspecifiedMatching 1:1 -ZFA:0009151 hatching gland cell semapv:crossSpeciesExactMatch CL:0000249 semapv:UnspecifiedMatching 1:1 -ZFA:0009152 extramedullary cell semapv:crossSpeciesExactMatch CL:0000251 semapv:UnspecifiedMatching 1:1 -ZFA:0009153 eurydendroid cell semapv:crossSpeciesExactMatch CL:0000253 semapv:UnspecifiedMatching 1:1 -ZFA:0009154 eye photoreceptor cell semapv:crossSpeciesExactMatch CL:0000287 semapv:UnspecifiedMatching 1:1 -ZFA:0009155 somatotropin secreting cell semapv:crossSpeciesExactMatch CL:0000295 semapv:UnspecifiedMatching 1:1 -ZFA:0009156 gamete semapv:crossSpeciesExactMatch CL:0000300 semapv:UnspecifiedMatching 1:1 -ZFA:0009157 keratin accumulating cell semapv:crossSpeciesExactMatch CL:0000311 semapv:UnspecifiedMatching 1:1 -ZFA:0009158 keratinocyte semapv:crossSpeciesExactMatch CL:0000312 semapv:UnspecifiedMatching 1:1 -ZFA:0009159 mucus secreting cell semapv:crossSpeciesExactMatch CL:0000319 semapv:UnspecifiedMatching 1:1 -ZFA:0009160 seminal fluid secreting cell semapv:crossSpeciesExactMatch CL:0000321 semapv:UnspecifiedMatching 1:1 -ZFA:0009162 extracellular matrix secreting cell semapv:crossSpeciesExactMatch CL:0000327 semapv:UnspecifiedMatching 1:1 -ZFA:0009163 myelin accumulating cell semapv:crossSpeciesExactMatch CL:0000328 semapv:UnspecifiedMatching 1:1 -ZFA:0009164 oxygen accumulating cell semapv:crossSpeciesExactMatch CL:0000329 semapv:UnspecifiedMatching 1:1 -ZFA:0009166 mesenchyme condensation cell semapv:crossSpeciesExactMatch CL:0000335 semapv:UnspecifiedMatching 1:1 -ZFA:0009167 adrenal medulla cell semapv:crossSpeciesExactMatch CL:0000336 semapv:UnspecifiedMatching 1:1 -ZFA:0009168 neuroblast (sensu Vertebrata) semapv:crossSpeciesExactMatch CL:0000337 semapv:UnspecifiedMatching 1:1 -ZFA:0009169 glioblast (sensu Vertebrata) semapv:crossSpeciesExactMatch CL:0000339 semapv:UnspecifiedMatching 1:1 -ZFA:0009170 pigment cell (sensu Vertebrata) semapv:crossSpeciesExactMatch CL:0000342 semapv:UnspecifiedMatching 1:1 -ZFA:0009171 visual pigment cell (sensu Vertebrata) semapv:crossSpeciesExactMatch CL:0000343 semapv:UnspecifiedMatching 1:1 -ZFA:0009173 dental papilla cell semapv:crossSpeciesExactMatch CL:0000345 semapv:UnspecifiedMatching 1:1 -ZFA:0009174 scleral cell semapv:crossSpeciesExactMatch CL:0000347 semapv:UnspecifiedMatching 1:1 -ZFA:0009175 choroidal cell of the eye semapv:crossSpeciesExactMatch CL:0000348 semapv:UnspecifiedMatching 1:1 -ZFA:0009176 extraembryonic cell semapv:crossSpeciesExactMatch CL:0000349 semapv:UnspecifiedMatching 1:1 -ZFA:0009177 blastoderm cell semapv:crossSpeciesExactMatch CL:0000353 semapv:UnspecifiedMatching 1:1 -ZFA:0009178 blastemal cell semapv:crossSpeciesExactMatch CL:0000354 semapv:UnspecifiedMatching 1:1 -ZFA:0009179 muscle stem cell semapv:crossSpeciesExactMatch CL:0000355 semapv:UnspecifiedMatching 1:1 -ZFA:0009180 stratified epithelial stem cell semapv:crossSpeciesExactMatch CL:0000357 semapv:UnspecifiedMatching 1:1 -ZFA:0009181 vascular associated smooth muscle cell semapv:crossSpeciesExactMatch CL:0000359 semapv:UnspecifiedMatching 1:1 -ZFA:0009182 gastrula cell semapv:crossSpeciesExactMatch CL:0000361 semapv:UnspecifiedMatching 1:1 -ZFA:0009183 epidermal cell semapv:crossSpeciesExactMatch CL:0000362 semapv:UnspecifiedMatching 1:1 -ZFA:0009184 osteoprogenitor cell semapv:crossSpeciesExactMatch CL:0000375 semapv:UnspecifiedMatching 1:1 -ZFA:0009185 sensory processing neuron semapv:crossSpeciesExactMatch CL:0000379 semapv:UnspecifiedMatching 1:1 -ZFA:0009186 neurosecretory neuron semapv:crossSpeciesExactMatch CL:0000381 semapv:UnspecifiedMatching 1:1 -ZFA:0009187 nephrogenic mesenchyme stem cell semapv:crossSpeciesExactMatch CL:0000383 semapv:UnspecifiedMatching 1:1 -ZFA:0009188 ligament cell semapv:crossSpeciesExactMatch CL:0000384 semapv:UnspecifiedMatching 1:1 -ZFA:0009189 tendon cell semapv:crossSpeciesExactMatch CL:0000388 semapv:UnspecifiedMatching 1:1 -ZFA:0009190 electrically responsive cell semapv:crossSpeciesExactMatch CL:0000393 semapv:UnspecifiedMatching 1:1 -ZFA:0009191 CNS interneuron semapv:crossSpeciesExactMatch CL:0000402 semapv:UnspecifiedMatching 1:1 -ZFA:0009193 electrically signaling cell semapv:crossSpeciesExactMatch CL:0000404 semapv:UnspecifiedMatching 1:1 -ZFA:0009194 CNS short range interneuron semapv:crossSpeciesExactMatch CL:0000406 semapv:UnspecifiedMatching 1:1 -ZFA:0009195 CNS long range interneuron semapv:crossSpeciesExactMatch CL:0000410 semapv:UnspecifiedMatching 1:1 -ZFA:0009196 hypodermal cell semapv:crossSpeciesExactMatch CL:0000411 semapv:UnspecifiedMatching 1:1 -ZFA:0009198 xanthophore semapv:crossSpeciesExactMatch CL:0000430 semapv:UnspecifiedMatching 1:1 -ZFA:0009199 iridophore semapv:crossSpeciesExactMatch CL:0000431 semapv:UnspecifiedMatching 1:1 -ZFA:0009200 reticular cell semapv:crossSpeciesExactMatch CL:0000432 semapv:UnspecifiedMatching 1:1 -ZFA:0009201 alkali secreting cell semapv:crossSpeciesExactMatch CL:0000435 semapv:UnspecifiedMatching 1:1 -ZFA:0009202 follicle stimulating hormone secreting cell semapv:crossSpeciesExactMatch CL:0000437 semapv:UnspecifiedMatching 1:1 -ZFA:0009203 luteinizing hormone secreting cell semapv:crossSpeciesExactMatch CL:0000438 semapv:UnspecifiedMatching 1:1 -ZFA:0009204 prolactin secreting cell semapv:crossSpeciesExactMatch CL:0000439 semapv:UnspecifiedMatching 1:1 -ZFA:0009205 melanocyte stimulating hormone secreting cell semapv:crossSpeciesExactMatch CL:0000440 semapv:UnspecifiedMatching 1:1 -ZFA:0009206 calcitonin secreting cell semapv:crossSpeciesExactMatch CL:0000443 semapv:UnspecifiedMatching 1:1 -ZFA:0009209 dendritic cell semapv:crossSpeciesExactMatch CL:0000451 semapv:UnspecifiedMatching 1:1 -ZFA:0009210 thyroid hormone secreting cell semapv:crossSpeciesExactMatch CL:0000452 semapv:UnspecifiedMatching 1:1 -ZFA:0009211 epinephrin secreting cell semapv:crossSpeciesExactMatch CL:0000454 semapv:UnspecifiedMatching 1:1 -ZFA:0009212 biogenic amine secreting cell semapv:crossSpeciesExactMatch CL:0000457 semapv:UnspecifiedMatching 1:1 -ZFA:0009213 serotonin secreting cell semapv:crossSpeciesExactMatch CL:0000458 semapv:UnspecifiedMatching 1:1 -ZFA:0009214 norepinephrine secreting cell semapv:crossSpeciesExactMatch CL:0000459 semapv:UnspecifiedMatching 1:1 -ZFA:0009215 glucocorticoid secreting cell semapv:crossSpeciesExactMatch CL:0000460 semapv:UnspecifiedMatching 1:1 -ZFA:0009216 adrenocorticotropic hormone secreting cell semapv:crossSpeciesExactMatch CL:0000467 semapv:UnspecifiedMatching 1:1 -ZFA:0009217 digestive enzyme secreting cell semapv:crossSpeciesExactMatch CL:0000470 semapv:UnspecifiedMatching 1:1 -ZFA:0009218 thyroid stimulating hormone secreting cell semapv:crossSpeciesExactMatch CL:0000476 semapv:UnspecifiedMatching 1:1 -ZFA:0009219 visible light photoreceptor cell semapv:crossSpeciesExactMatch CL:0000488 semapv:UnspecifiedMatching 1:1 -ZFA:0009220 photopic photoreceptor cell semapv:crossSpeciesExactMatch CL:0000490 semapv:UnspecifiedMatching 1:1 -ZFA:0009221 UV sensitive photoreceptor cell semapv:crossSpeciesExactMatch CL:0000494 semapv:UnspecifiedMatching 1:1 -ZFA:0009222 blue sensitive photoreceptor cell semapv:crossSpeciesExactMatch CL:0000495 semapv:UnspecifiedMatching 1:1 -ZFA:0009223 green sensitive photoreceptor cell semapv:crossSpeciesExactMatch CL:0000496 semapv:UnspecifiedMatching 1:1 -ZFA:0009224 red sensitive photoreceptor cell semapv:crossSpeciesExactMatch CL:0000497 semapv:UnspecifiedMatching 1:1 -ZFA:0009225 inhibitory interneuron semapv:crossSpeciesExactMatch CL:0000498 semapv:UnspecifiedMatching 1:1 -ZFA:0009226 stromal cell semapv:crossSpeciesExactMatch CL:0000499 semapv:UnspecifiedMatching 1:1 -ZFA:0009227 granulosa cell semapv:crossSpeciesExactMatch CL:0000501 semapv:UnspecifiedMatching 1:1 -ZFA:0009228 D cell semapv:crossSpeciesExactMatch CL:0000502 semapv:UnspecifiedMatching 1:1 -ZFA:0009229 theca cell semapv:crossSpeciesExactMatch CL:0000503 semapv:UnspecifiedMatching 1:1 -ZFA:0009230 substance P secreting cell semapv:crossSpeciesExactMatch CL:0000505 semapv:UnspecifiedMatching 1:1 -ZFA:0009231 enkephalin secreting cell semapv:crossSpeciesExactMatch CL:0000506 semapv:UnspecifiedMatching 1:1 -ZFA:0009232 endorphin secreting cell semapv:crossSpeciesExactMatch CL:0000507 semapv:UnspecifiedMatching 1:1 -ZFA:0009233 paracrine cell semapv:crossSpeciesExactMatch CL:0000512 semapv:UnspecifiedMatching 1:1 -ZFA:0009234 cardiac muscle myoblast semapv:crossSpeciesExactMatch CL:0000513 semapv:UnspecifiedMatching 1:1 -ZFA:0009235 smooth muscle myoblast semapv:crossSpeciesExactMatch CL:0000514 semapv:UnspecifiedMatching 1:1 -ZFA:0009236 skeletal muscle myoblast semapv:crossSpeciesExactMatch CL:0000515 semapv:UnspecifiedMatching 1:1 -ZFA:0009237 perineuronal satellite cell semapv:crossSpeciesExactMatch CL:0000516 semapv:UnspecifiedMatching 1:1 -ZFA:0009238 afferent neuron semapv:crossSpeciesExactMatch CL:0000526 semapv:UnspecifiedMatching 1:1 -ZFA:0009239 efferent neuron semapv:crossSpeciesExactMatch CL:0000527 semapv:UnspecifiedMatching 1:1 -ZFA:0009240 nitrergic neuron semapv:crossSpeciesExactMatch CL:0000528 semapv:UnspecifiedMatching 1:1 -ZFA:0009241 pigmented epithelial cell semapv:crossSpeciesExactMatch CL:0000529 semapv:UnspecifiedMatching 1:1 -ZFA:0009242 primary neuron semapv:crossSpeciesExactMatch CL:0000530 semapv:UnspecifiedMatching 1:1 -ZFA:0009243 CaP motoneuron semapv:crossSpeciesExactMatch CL:0000532 semapv:UnspecifiedMatching 1:1 -ZFA:0009244 primary motor neuron semapv:crossSpeciesExactMatch CL:0000533 semapv:UnspecifiedMatching 1:1 -ZFA:0009245 primary interneuron semapv:crossSpeciesExactMatch CL:0000534 semapv:UnspecifiedMatching 1:1 -ZFA:0009246 secondary neuron semapv:crossSpeciesExactMatch CL:0000535 semapv:UnspecifiedMatching 1:1 -ZFA:0009247 secondary motor neuron semapv:crossSpeciesExactMatch CL:0000536 semapv:UnspecifiedMatching 1:1 -ZFA:0009248 neuron semapv:crossSpeciesExactMatch CL:0000540 semapv:UnspecifiedMatching 1:1 -ZFA:0009249 melanoblast semapv:crossSpeciesExactMatch CL:0000541 semapv:UnspecifiedMatching 1:1 -ZFA:0009250 lymphocyte semapv:crossSpeciesExactMatch CL:0000542 semapv:UnspecifiedMatching 1:1 -ZFA:0009251 granulocyte monocyte progenitor cell semapv:crossSpeciesExactMatch CL:0000557 semapv:UnspecifiedMatching 1:1 -ZFA:0009252 reticulocyte semapv:crossSpeciesExactMatch CL:0000558 semapv:UnspecifiedMatching 1:1 -ZFA:0009253 promonocyte semapv:crossSpeciesExactMatch CL:0000559 semapv:UnspecifiedMatching 1:1 -ZFA:0009254 band form neutrophil semapv:crossSpeciesExactMatch CL:0000560 semapv:UnspecifiedMatching 1:1 -ZFA:0009255 amacrine cell semapv:crossSpeciesExactMatch CL:0000561 semapv:UnspecifiedMatching 1:1 -ZFA:0009256 nucleate erythrocyte semapv:crossSpeciesExactMatch CL:0000562 semapv:UnspecifiedMatching 1:1 -ZFA:0009257 neutrophilic promyelocyte semapv:crossSpeciesExactMatch CL:0000564 semapv:UnspecifiedMatching 1:1 -ZFA:0009258 angioblastic mesenchymal cell semapv:crossSpeciesExactMatch CL:0000566 semapv:UnspecifiedMatching 1:1 -ZFA:0009259 cardiac mesenchymal cell semapv:crossSpeciesExactMatch CL:0000569 semapv:UnspecifiedMatching 1:1 -ZFA:0009260 parafollicular cell semapv:crossSpeciesExactMatch CL:0000570 semapv:UnspecifiedMatching 1:1 -ZFA:0009261 leucophore semapv:crossSpeciesExactMatch CL:0000571 semapv:UnspecifiedMatching 1:1 -ZFA:0009262 retinal cone cell semapv:crossSpeciesExactMatch CL:0000573 semapv:UnspecifiedMatching 1:1 -ZFA:0009263 erythrophore semapv:crossSpeciesExactMatch CL:0000574 semapv:UnspecifiedMatching 1:1 -ZFA:0009264 corneal epithelial cell semapv:crossSpeciesExactMatch CL:0000575 semapv:UnspecifiedMatching 1:1 -ZFA:0009265 monocyte semapv:crossSpeciesExactMatch CL:0000576 semapv:UnspecifiedMatching 1:1 -ZFA:0009266 neutrophilic myelocyte semapv:crossSpeciesExactMatch CL:0000580 semapv:UnspecifiedMatching 1:1 -ZFA:0009267 peritoneal macrophage semapv:crossSpeciesExactMatch CL:0000581 semapv:UnspecifiedMatching 1:1 -ZFA:0009268 neutrophilic metamyelocyte semapv:crossSpeciesExactMatch CL:0000582 semapv:UnspecifiedMatching 1:1 -ZFA:0009269 enterocyte semapv:crossSpeciesExactMatch CL:0000584 semapv:UnspecifiedMatching 1:1 -ZFA:0009270 odontoclast semapv:crossSpeciesExactMatch CL:0000588 semapv:UnspecifiedMatching 1:1 -ZFA:0009271 androgen secreting cell semapv:crossSpeciesExactMatch CL:0000593 semapv:UnspecifiedMatching 1:1 -ZFA:0009272 skeletal muscle satellite cell semapv:crossSpeciesExactMatch CL:0000594 semapv:UnspecifiedMatching 1:1 -ZFA:0009273 pyramidal cell semapv:crossSpeciesExactMatch CL:0000598 semapv:UnspecifiedMatching 1:1 -ZFA:0009274 pressoreceptor cell semapv:crossSpeciesExactMatch CL:0000602 semapv:UnspecifiedMatching 1:1 -ZFA:0009275 retinal rod cell semapv:crossSpeciesExactMatch CL:0000604 semapv:UnspecifiedMatching 1:1 -ZFA:0009276 GABAergic neuron semapv:crossSpeciesExactMatch CL:0000617 semapv:UnspecifiedMatching 1:1 -ZFA:0009277 acinar cell semapv:crossSpeciesExactMatch CL:0000622 semapv:UnspecifiedMatching 1:1 -ZFA:0009278 natural killer cell semapv:crossSpeciesExactMatch CL:0000623 semapv:UnspecifiedMatching 1:1 -ZFA:0009279 ito cell semapv:crossSpeciesExactMatch CL:0000632 semapv:UnspecifiedMatching 1:1 -ZFA:0009280 Muller cell semapv:crossSpeciesExactMatch CL:0000636 semapv:UnspecifiedMatching 1:1 -ZFA:0009281 folliculostellate cell semapv:crossSpeciesExactMatch CL:0000642 semapv:UnspecifiedMatching 1:1 -ZFA:0009282 Bergmann glial cell semapv:crossSpeciesExactMatch CL:0000644 semapv:UnspecifiedMatching 1:1 -ZFA:0009283 mesangial cell semapv:crossSpeciesExactMatch CL:0000650 semapv:UnspecifiedMatching 1:1 -ZFA:0009284 pinealocyte semapv:crossSpeciesExactMatch CL:0000652 semapv:UnspecifiedMatching 1:1 -ZFA:0009285 podocyte semapv:crossSpeciesExactMatch CL:0000653 semapv:UnspecifiedMatching 1:1 -ZFA:0009286 fenestrated cell semapv:crossSpeciesExactMatch CL:0000666 semapv:UnspecifiedMatching 1:1 -ZFA:0009287 collagen secreting cell semapv:crossSpeciesExactMatch CL:0000667 semapv:UnspecifiedMatching 1:1 -ZFA:0009288 primordial germ cell semapv:crossSpeciesExactMatch CL:0000670 semapv:UnspecifiedMatching 1:1 -ZFA:0009289 gut absorptive cell semapv:crossSpeciesExactMatch CL:0000677 semapv:UnspecifiedMatching 1:1 -ZFA:0009290 glutamatergic neuron semapv:crossSpeciesExactMatch CL:0000679 semapv:UnspecifiedMatching 1:1 -ZFA:0009291 muscle precursor cell semapv:crossSpeciesExactMatch CL:0000680 semapv:UnspecifiedMatching 1:1 -ZFA:0009292 radial glial cell semapv:crossSpeciesExactMatch CL:0000681 semapv:UnspecifiedMatching 1:1 -ZFA:0009293 M cell semapv:crossSpeciesExactMatch CL:0000682 semapv:UnspecifiedMatching 1:1 -ZFA:0009294 ependymoglial cell semapv:crossSpeciesExactMatch CL:0000683 semapv:UnspecifiedMatching 1:1 -ZFA:0009295 cerebrospinal fluid secreting cell semapv:crossSpeciesExactMatch CL:0000686 semapv:UnspecifiedMatching 1:1 -ZFA:0009296 perijunctional fibroblast semapv:crossSpeciesExactMatch CL:0000688 semapv:UnspecifiedMatching 1:1 -ZFA:0009297 stellate interneuron semapv:crossSpeciesExactMatch CL:0000691 semapv:UnspecifiedMatching 1:1 -ZFA:0009298 terminal Schwann cell semapv:crossSpeciesExactMatch CL:0000692 semapv:UnspecifiedMatching 1:1 -ZFA:0009299 neuroglioform cell semapv:crossSpeciesExactMatch CL:0000693 semapv:UnspecifiedMatching 1:1 -ZFA:0009300 Cajal-Retzius cell semapv:crossSpeciesExactMatch CL:0000695 semapv:UnspecifiedMatching 1:1 -ZFA:0009301 dopaminergic neuron semapv:crossSpeciesExactMatch CL:0000700 semapv:UnspecifiedMatching 1:1 -ZFA:0009302 sustentacular cell semapv:crossSpeciesExactMatch CL:0000703 semapv:UnspecifiedMatching 1:1 -ZFA:0009303 endothelial tip cell semapv:crossSpeciesExactMatch CL:0000704 semapv:UnspecifiedMatching 1:1 -ZFA:0009304 choroid plexus epithelial cell semapv:crossSpeciesExactMatch CL:0000706 semapv:UnspecifiedMatching 1:1 -ZFA:0009305 leptomeningeal cell semapv:crossSpeciesExactMatch CL:0000708 semapv:UnspecifiedMatching 1:1 -ZFA:0009307 somatic stem cell semapv:crossSpeciesExactMatch CL:0000723 semapv:UnspecifiedMatching 1:1 -ZFA:0009308 urothelial cell semapv:crossSpeciesExactMatch CL:0000731 semapv:UnspecifiedMatching 1:1 -ZFA:0009309 leukocyte semapv:crossSpeciesExactMatch CL:0000738 semapv:UnspecifiedMatching 1:1 -ZFA:0009310 retinal ganglion cell semapv:crossSpeciesExactMatch CL:0000740 semapv:UnspecifiedMatching 1:1 -ZFA:0009311 spinal accessory motor neuron semapv:crossSpeciesExactMatch CL:0000741 semapv:UnspecifiedMatching 1:1 -ZFA:0009312 periarticular chondrocyte semapv:crossSpeciesExactMatch CL:0000742 semapv:UnspecifiedMatching 1:1 -ZFA:0009313 hypertrophic chondrocyte semapv:crossSpeciesExactMatch CL:0000743 semapv:UnspecifiedMatching 1:1 -ZFA:0009314 columnar chondrocyte semapv:crossSpeciesExactMatch CL:0000744 semapv:UnspecifiedMatching 1:1 -ZFA:0009315 horizontal cell semapv:crossSpeciesExactMatch CL:0000745 semapv:UnspecifiedMatching 1:1 -ZFA:0009316 cardiac muscle cell semapv:crossSpeciesExactMatch CL:0000746 semapv:UnspecifiedMatching 1:1 -ZFA:0009317 cyanophore semapv:crossSpeciesExactMatch CL:0000747 semapv:UnspecifiedMatching 1:1 -ZFA:0009318 retinal bipolar neuron semapv:crossSpeciesExactMatch CL:0000748 semapv:UnspecifiedMatching 1:1 -ZFA:0009319 ON-bipolar cell semapv:crossSpeciesExactMatch CL:0000749 semapv:UnspecifiedMatching 1:1 -ZFA:0009320 OFF-bipolar cell semapv:crossSpeciesExactMatch CL:0000750 semapv:UnspecifiedMatching 1:1 -ZFA:0009321 rod bipolar cell semapv:crossSpeciesExactMatch CL:0000751 semapv:UnspecifiedMatching 1:1 -ZFA:0009322 cone retinal bipolar cell semapv:crossSpeciesExactMatch CL:0000752 semapv:UnspecifiedMatching 1:1 -ZFA:0009323 thrombocyte semapv:crossSpeciesExactMatch CL:0000762 semapv:UnspecifiedMatching 1:1 -ZFA:0009324 myeloid cell semapv:crossSpeciesExactMatch CL:0000763 semapv:UnspecifiedMatching 1:1 -ZFA:0009325 erythroid lineage cell semapv:crossSpeciesExactMatch CL:0000764 semapv:UnspecifiedMatching 1:1 -ZFA:0009326 myeloid leukocyte semapv:crossSpeciesExactMatch CL:0000766 semapv:UnspecifiedMatching 1:1 -ZFA:0009327 neutrophil semapv:crossSpeciesExactMatch CL:0000775 semapv:UnspecifiedMatching 1:1 -ZFA:0009328 immature neutrophil semapv:crossSpeciesExactMatch CL:0000776 semapv:UnspecifiedMatching 1:1 -ZFA:0009329 mononuclear osteoclast semapv:crossSpeciesExactMatch CL:0000778 semapv:UnspecifiedMatching 1:1 -ZFA:0009330 mononuclear odontoclast semapv:crossSpeciesExactMatch CL:0000781 semapv:UnspecifiedMatching 1:1 -ZFA:0009331 mature B cell semapv:crossSpeciesExactMatch CL:0000785 semapv:UnspecifiedMatching 1:1 -ZFA:0009332 plasma cell semapv:crossSpeciesExactMatch CL:0000786 semapv:UnspecifiedMatching 1:1 -ZFA:0009333 memory B cell semapv:crossSpeciesExactMatch CL:0000787 semapv:UnspecifiedMatching 1:1 -ZFA:0009334 naive B cell semapv:crossSpeciesExactMatch CL:0000788 semapv:UnspecifiedMatching 1:1 -ZFA:0009335 alpha-beta T cell semapv:crossSpeciesExactMatch CL:0000789 semapv:UnspecifiedMatching 1:1 -ZFA:0009336 gamma-delta T cell semapv:crossSpeciesExactMatch CL:0000798 semapv:UnspecifiedMatching 1:1 -ZFA:0009337 immature gamma-delta T cell semapv:crossSpeciesExactMatch CL:0000799 semapv:UnspecifiedMatching 1:1 -ZFA:0009338 mature gamma-delta T cell semapv:crossSpeciesExactMatch CL:0000800 semapv:UnspecifiedMatching 1:1 -ZFA:0009339 gamma-delta intraepithelial T cell semapv:crossSpeciesExactMatch CL:0000801 semapv:UnspecifiedMatching 1:1 -ZFA:0009342 memory T cell semapv:crossSpeciesExactMatch CL:0000813 semapv:UnspecifiedMatching 1:1 -ZFA:0009343 immature B cell semapv:crossSpeciesExactMatch CL:0000816 semapv:UnspecifiedMatching 1:1 -ZFA:0009344 precursor B cell semapv:crossSpeciesExactMatch CL:0000817 semapv:UnspecifiedMatching 1:1 -ZFA:0009345 transitional stage B cell semapv:crossSpeciesExactMatch CL:0000818 semapv:UnspecifiedMatching 1:1 -ZFA:0009346 immature natural killer cell semapv:crossSpeciesExactMatch CL:0000823 semapv:UnspecifiedMatching 1:1 -ZFA:0009347 mature natural killer cell semapv:crossSpeciesExactMatch CL:0000824 semapv:UnspecifiedMatching 1:1 -ZFA:0009348 pro-NK cell semapv:crossSpeciesExactMatch CL:0000825 semapv:UnspecifiedMatching 1:1 -ZFA:0009349 pro-B cell semapv:crossSpeciesExactMatch CL:0000826 semapv:UnspecifiedMatching 1:1 -ZFA:0009350 pro-T cell semapv:crossSpeciesExactMatch CL:0000827 semapv:UnspecifiedMatching 1:1 -ZFA:0009351 thromboblast semapv:crossSpeciesExactMatch CL:0000828 semapv:UnspecifiedMatching 1:1 -ZFA:0009352 neutrophil progenitor cell semapv:crossSpeciesExactMatch CL:0000834 semapv:UnspecifiedMatching 1:1 -ZFA:0009353 myeloblast semapv:crossSpeciesExactMatch CL:0000835 semapv:UnspecifiedMatching 1:1 -ZFA:0009354 hematopoietic multipotent progenitor cell semapv:crossSpeciesExactMatch CL:0000837 semapv:UnspecifiedMatching 1:1 -ZFA:0009355 lymphoid progenitor cell semapv:crossSpeciesExactMatch CL:0000838 semapv:UnspecifiedMatching 1:1 -ZFA:0009356 myeloid lineage restricted progenitor cell semapv:crossSpeciesExactMatch CL:0000839 semapv:UnspecifiedMatching 1:1 -ZFA:0009357 mononuclear cell semapv:crossSpeciesExactMatch CL:0000842 semapv:UnspecifiedMatching 1:1 -ZFA:0009358 ciliated olfactory receptor neuron semapv:crossSpeciesExactMatch CL:0000847 semapv:UnspecifiedMatching 1:1 -ZFA:0009359 microvillous olfactory receptor neuron semapv:crossSpeciesExactMatch CL:0000848 semapv:UnspecifiedMatching 1:1 -ZFA:0009360 crypt olfactory receptor neuron semapv:crossSpeciesExactMatch CL:0000849 semapv:UnspecifiedMatching 1:1 -ZFA:0009361 serotonergic neuron semapv:crossSpeciesExactMatch CL:0000850 semapv:UnspecifiedMatching 1:1 -ZFA:0009362 neuromast mantle cell semapv:crossSpeciesExactMatch CL:0000851 semapv:UnspecifiedMatching 1:1 -ZFA:0009363 neuromast support cell semapv:crossSpeciesExactMatch CL:0000852 semapv:UnspecifiedMatching 1:1 -ZFA:0009364 olfactory epithelial support cell semapv:crossSpeciesExactMatch CL:0000853 semapv:UnspecifiedMatching 1:1 -ZFA:0009365 interneuromast cell semapv:crossSpeciesExactMatch CL:0000854 semapv:UnspecifiedMatching 1:1 -ZFA:0009366 hair cell semapv:crossSpeciesExactMatch CL:0000855 semapv:UnspecifiedMatching 1:1 -ZFA:0009367 neuromast hair cell semapv:crossSpeciesExactMatch CL:0000856 semapv:UnspecifiedMatching 1:1 -ZFA:0009368 slow muscle myoblast semapv:crossSpeciesExactMatch CL:0000857 semapv:UnspecifiedMatching 1:1 -ZFA:0009369 fast muscle myoblast semapv:crossSpeciesExactMatch CL:0000858 semapv:UnspecifiedMatching 1:1 -ZFA:0009370 stretch receptor cell semapv:crossSpeciesExactMatch CL:1000082 semapv:UnspecifiedMatching 1:1 -ZFA:0009371 stratified keratinized epithelial stem cell semapv:crossSpeciesExactMatch CL:1000083 semapv:UnspecifiedMatching 1:1 -ZFA:0009372 duct epithelial cell semapv:crossSpeciesExactMatch CL:0000068 semapv:UnspecifiedMatching 1:1 -ZFA:0009374 kidney epithelial cell semapv:crossSpeciesExactMatch CL:0002518 semapv:UnspecifiedMatching 1:1 -ZFA:0009375 renal intercalated cell semapv:crossSpeciesExactMatch CL:0005010 semapv:UnspecifiedMatching 1:1 -ZFA:0009376 renal alpha-intercalated cell semapv:crossSpeciesExactMatch CL:0005011 semapv:UnspecifiedMatching 1:1 -ZFA:0009379 intrahepatic bile duct epithelial cell semapv:crossSpeciesExactMatch CL:0002538 semapv:UnspecifiedMatching 1:1 -ZFA:0009380 pancreatic ductal cell semapv:crossSpeciesExactMatch CL:0002079 semapv:UnspecifiedMatching 1:1 -ZFA:0009383 endo-epithelial cell semapv:crossSpeciesExactMatch CL:0002076 semapv:UnspecifiedMatching 1:1 -ZFA:0009385 ecto-epithelial cell semapv:crossSpeciesExactMatch CL:0002077 semapv:UnspecifiedMatching 1:1 -ZFA:0009386 somatic cell semapv:crossSpeciesExactMatch CL:0002371 semapv:UnspecifiedMatching 1:1 -ZFA:0009387 supportive cell semapv:crossSpeciesExactMatch CL:0000630 semapv:UnspecifiedMatching 1:1 -ZFA:0009388 meso-epithelial cell semapv:crossSpeciesExactMatch CL:0002078 semapv:UnspecifiedMatching 1:1 -ZFA:0009389 kidney cell semapv:crossSpeciesExactMatch CL:1000497 semapv:UnspecifiedMatching 1:1 -ZFA:0009390 kidney interstitial cell semapv:crossSpeciesExactMatch CL:1000500 semapv:UnspecifiedMatching 1:1 -ZFA:0009391 kidney medulla cell semapv:crossSpeciesExactMatch CL:1000504 semapv:UnspecifiedMatching 1:1 -ZFA:0009392 connective tissue cell semapv:crossSpeciesExactMatch CL:0002320 semapv:UnspecifiedMatching 1:1 -ZFA:0009393 lymphangioblast semapv:crossSpeciesExactMatch CL:0005020 semapv:UnspecifiedMatching 1:1 -ZFA:0009394 mesenchymal lymphangioblast semapv:crossSpeciesExactMatch CL:0005021 semapv:UnspecifiedMatching 1:1 -ZFA:0009395 vascular lymphangioblast semapv:crossSpeciesExactMatch CL:0005022 semapv:UnspecifiedMatching 1:1 -ZFA:0009396 glycinergic neuron semapv:crossSpeciesExactMatch CL:1001509 semapv:UnspecifiedMatching 1:1 -ZFA:0009397 cholangiocyte semapv:crossSpeciesExactMatch CL:1000488 semapv:UnspecifiedMatching 1:1 -ZFA:0009399 intestinal epithelial cell semapv:crossSpeciesExactMatch CL:0002563 semapv:UnspecifiedMatching 1:1 -ZFA:0009400 epithelial cell of esophagus semapv:crossSpeciesExactMatch CL:0002252 semapv:UnspecifiedMatching 1:1 -ZFA:0009401 lens fiber cell semapv:crossSpeciesExactMatch CL:0011004 semapv:UnspecifiedMatching 1:1 -ZFA:0009402 heart valve cell semapv:crossSpeciesExactMatch CL:1000147 semapv:UnspecifiedMatching 1:1 +#object_source: "http://purl.obolibrary.org/obo/cl.owl" +subject_id subject_label predicate_id object_id object_label mapping_justification +ZFA:0000003 adaxial cell semapv:crossSpeciesExactMatch CL:0007016 adaxial cell semapv:UnspecifiedMatching +ZFA:0000084 yolk semapv:crossSpeciesExactMatch CL:0000428 yolk cell semapv:UnspecifiedMatching +ZFA:0000778 spinal cord interneuron semapv:crossSpeciesExactMatch CL:0005000 spinal cord interneuron semapv:UnspecifiedMatching +ZFA:0001109 oocyte semapv:crossSpeciesExactMatch CL:0000023 oocyte semapv:UnspecifiedMatching +ZFA:0001570 unfertilized egg semapv:crossSpeciesExactMatch CL:0000025 egg cell semapv:UnspecifiedMatching +ZFA:0001691 cerebellar granule cell semapv:crossSpeciesExactMatch CL:0001031 cerebellar granule cell semapv:UnspecifiedMatching +ZFA:0001694 olfactory granule cell semapv:crossSpeciesExactMatch CL:0000626 olfactory granule cell semapv:UnspecifiedMatching +ZFA:0001725 immature Schwann cell semapv:crossSpeciesExactMatch CL:0002377 immature Schwann cell semapv:UnspecifiedMatching +ZFA:0005236 basophilic erythroblast semapv:crossSpeciesExactMatch CL:0000549 basophilic erythroblast semapv:UnspecifiedMatching +ZFA:0005237 erythroblast semapv:crossSpeciesExactMatch CL:0000765 erythroblast semapv:UnspecifiedMatching +ZFA:0005238 juxtaglomerular cell semapv:crossSpeciesExactMatch CL:0000648 kidney granular cell semapv:UnspecifiedMatching +ZFA:0005239 micropylar cell semapv:crossSpeciesExactMatch CL:0007022 micropylar cell semapv:UnspecifiedMatching +ZFA:0005240 Kolmer-Agduhr neuron semapv:crossSpeciesExactMatch CL:0005007 Kolmer-Agduhr neuron semapv:UnspecifiedMatching +ZFA:0005241 polychromatophilic erythroblast semapv:crossSpeciesExactMatch CL:0000550 polychromatophilic erythroblast semapv:UnspecifiedMatching +ZFA:0005242 multi-ciliated epithelial cell semapv:crossSpeciesExactMatch CL:0005012 multi-ciliated epithelial cell semapv:UnspecifiedMatching +ZFA:0005243 single ciliated epithelial cell semapv:crossSpeciesExactMatch CL:0005013 single ciliated epithelial cell semapv:UnspecifiedMatching +ZFA:0005244 auditory epithelial support cell semapv:crossSpeciesExactMatch CL:0005014 auditory epithelial supporting cell semapv:UnspecifiedMatching +ZFA:0005245 xanthoblast semapv:crossSpeciesExactMatch CL:0005002 xanthoblast semapv:UnspecifiedMatching +ZFA:0005322 renal principal cell semapv:crossSpeciesExactMatch CL:0005009 renal principal cell semapv:UnspecifiedMatching +ZFA:0005323 ionocyte semapv:crossSpeciesExactMatch CL:0005006 ionocyte semapv:UnspecifiedMatching +ZFA:0005328 iridoblast semapv:crossSpeciesExactMatch CL:0005001 iridoblast semapv:UnspecifiedMatching +ZFA:0005329 leucoblast semapv:crossSpeciesExactMatch CL:0005003 leucoblast semapv:UnspecifiedMatching +ZFA:0005331 pigment erythroblast semapv:crossSpeciesExactMatch CL:0005004 pigment erythroblast semapv:UnspecifiedMatching +ZFA:0005332 cyanoblast semapv:crossSpeciesExactMatch CL:0005005 cyanoblast semapv:UnspecifiedMatching +ZFA:0005565 tether cell semapv:crossSpeciesExactMatch CL:0002450 tether cell semapv:UnspecifiedMatching +ZFA:0005598 pancreatic epsilon cell semapv:crossSpeciesExactMatch CL:0005019 pancreatic epsilon cell semapv:UnspecifiedMatching +ZFA:0005599 ghrelin secreting cell semapv:crossSpeciesExactMatch CL:0005018 ghrelin secreting cell semapv:UnspecifiedMatching +ZFA:0005730 cranial motor neuron semapv:crossSpeciesExactMatch CL:0015000 cranial motor neuron semapv:UnspecifiedMatching +ZFA:0005731 branchiomotor neuron semapv:crossSpeciesExactMatch CL:0005023 branchiomotor neuron semapv:UnspecifiedMatching +ZFA:0005732 visceromotor neuron semapv:crossSpeciesExactMatch CL:0005025 visceromotor neuron semapv:UnspecifiedMatching +ZFA:0005733 somatomotor neuron semapv:crossSpeciesExactMatch CL:0005024 somatomotor neuron semapv:UnspecifiedMatching +ZFA:0005739 pancreatic acinar cell semapv:crossSpeciesExactMatch CL:0002064 pancreatic acinar cell semapv:UnspecifiedMatching +ZFA:0005740 pancreatic centroacinar cell semapv:crossSpeciesExactMatch CL:0002080 pancreatic centro-acinar cell semapv:UnspecifiedMatching +ZFA:0005742 pancreatic PP cell semapv:crossSpeciesExactMatch CL:0002275 pancreatic PP cell semapv:UnspecifiedMatching +ZFA:0005743 pancreatic D cell semapv:crossSpeciesExactMatch CL:0000173 pancreatic D cell semapv:UnspecifiedMatching +ZFA:0005744 notochord outer sheath cell semapv:crossSpeciesExactMatch CL:0007007 notochordal sheath cell semapv:UnspecifiedMatching +ZFA:0005745 structural cell semapv:crossSpeciesExactMatch CL:0000293 structural cell semapv:UnspecifiedMatching +ZFA:0005769 spermatid semapv:crossSpeciesExactMatch CL:0000018 spermatid semapv:UnspecifiedMatching +ZFA:0005773 embryonic blood vessel endothelial progenitor cell semapv:crossSpeciesExactMatch CL:0002546 embryonic blood vessel endothelial progenitor cell semapv:UnspecifiedMatching +ZFA:0005775 enteric neuron semapv:crossSpeciesExactMatch CL:0007011 enteric neuron semapv:UnspecifiedMatching +ZFA:0005776 parasympathetic neuron semapv:crossSpeciesExactMatch CL:0011102 parasympathetic neuron semapv:UnspecifiedMatching +ZFA:0005777 sympathetic neuron semapv:crossSpeciesExactMatch CL:0011103 sympathetic neuron semapv:UnspecifiedMatching +ZFA:0005778 hypocretin-secreting neuron semapv:crossSpeciesExactMatch CL:0011109 hypocretin-secreting neuron semapv:UnspecifiedMatching +ZFA:0005784 striated muscle cell semapv:crossSpeciesExactMatch CL:0000737 striated muscle cell semapv:UnspecifiedMatching +ZFA:0005830 hematopoietic cell semapv:crossSpeciesExactMatch CL:0000988 hematopoietic cell semapv:UnspecifiedMatching +ZFA:0005873 noradrenergic neuron semapv:crossSpeciesExactMatch CL:0008025 noradrenergic neuron semapv:UnspecifiedMatching +ZFA:0005878 oogonia semapv:crossSpeciesExactMatch CL:0000024 oogonial cell semapv:UnspecifiedMatching +ZFA:0005944 mural cell semapv:crossSpeciesExactMatch CL:0008034 mural cell semapv:UnspecifiedMatching +ZFA:0005956 germline stem cell semapv:crossSpeciesExactMatch CL:0000014 germ line stem cell semapv:UnspecifiedMatching +ZFA:0005957 stem cell semapv:crossSpeciesExactMatch CL:0000034 stem cell semapv:UnspecifiedMatching +ZFA:0007084 premigratory neural crest cell semapv:crossSpeciesExactMatch CL:0007004 premigratory neural crest cell semapv:UnspecifiedMatching +ZFA:0007086 migratory neural crest cell semapv:crossSpeciesExactMatch CL:0000333 migratory neural crest cell semapv:UnspecifiedMatching +ZFA:0007089 embryonic cell semapv:crossSpeciesExactMatch CL:0002321 embryonic cell (metazoa) semapv:UnspecifiedMatching +ZFA:0007091 migratory cranial neural crest cell semapv:crossSpeciesExactMatch CL:0000008 migratory cranial neural crest cell semapv:UnspecifiedMatching +ZFA:0007095 migratory trunk neural crest cell semapv:crossSpeciesExactMatch CL:0000011 migratory trunk neural crest cell semapv:UnspecifiedMatching +ZFA:0007122 epidermal stem cell semapv:crossSpeciesExactMatch CL:1000428 stem cell of epidermis semapv:UnspecifiedMatching +ZFA:0009000 cell semapv:crossSpeciesExactMatch CL:0000000 cell semapv:UnspecifiedMatching +ZFA:0009001 receptor cell (sensu Animalia) semapv:crossSpeciesExactMatch CL:0000006 neuronal receptor cell semapv:UnspecifiedMatching +ZFA:0009002 early embryonic cell semapv:crossSpeciesExactMatch CL:0000007 early embryonic cell (metazoa) semapv:UnspecifiedMatching +ZFA:0009005 spermatocyte semapv:crossSpeciesExactMatch CL:0000017 spermatocyte semapv:UnspecifiedMatching +ZFA:0009006 sperm semapv:crossSpeciesExactMatch CL:0000019 sperm semapv:UnspecifiedMatching +ZFA:0009007 spermatogonium semapv:crossSpeciesExactMatch CL:0000020 spermatogonium semapv:UnspecifiedMatching +ZFA:0009009 neuron neural crest derived semapv:crossSpeciesExactMatch CL:0000029 neural crest derived neuron semapv:UnspecifiedMatching +ZFA:0009010 glioblast semapv:crossSpeciesExactMatch CL:0000030 glioblast semapv:UnspecifiedMatching +ZFA:0009011 neuroblast semapv:crossSpeciesExactMatch CL:0000031 neuroblast (sensu Vertebrata) semapv:UnspecifiedMatching +ZFA:0009012 neuroplacodal cell semapv:crossSpeciesExactMatch CL:0000032 neuroplacodal cell semapv:UnspecifiedMatching +ZFA:0009013 single fate stem cell semapv:crossSpeciesExactMatch CL:0000035 single fate stem cell semapv:UnspecifiedMatching +ZFA:0009014 hematopoietic stem cell semapv:crossSpeciesExactMatch CL:0000037 hematopoietic stem cell semapv:UnspecifiedMatching +ZFA:0009015 erythroid progenitor cell semapv:crossSpeciesExactMatch CL:0000038 erythroid progenitor cell semapv:UnspecifiedMatching +ZFA:0009016 germ line cell semapv:crossSpeciesExactMatch CL:0000039 germ line cell semapv:UnspecifiedMatching +ZFA:0009017 monoblast semapv:crossSpeciesExactMatch CL:0000040 monoblast semapv:UnspecifiedMatching +ZFA:0009018 neutrophilic myeloblast semapv:crossSpeciesExactMatch CL:0000042 neutrophilic myeloblast semapv:UnspecifiedMatching +ZFA:0009019 neuronal stem cell semapv:crossSpeciesExactMatch CL:0000047 neural stem cell semapv:UnspecifiedMatching +ZFA:0009020 multi fate stem cell semapv:crossSpeciesExactMatch CL:0000048 multi fate stem cell semapv:UnspecifiedMatching +ZFA:0009021 common myeloid progenitor semapv:crossSpeciesExactMatch CL:0000049 common myeloid progenitor semapv:UnspecifiedMatching +ZFA:0009022 megakaryocyte erythroid progenitor cell semapv:crossSpeciesExactMatch CL:0000050 megakaryocyte-erythroid progenitor cell semapv:UnspecifiedMatching +ZFA:0009023 common lymphoid progenitor semapv:crossSpeciesExactMatch CL:0000051 common lymphoid progenitor semapv:UnspecifiedMatching +ZFA:0009024 totipotent stem cell semapv:crossSpeciesExactMatch CL:0000052 totipotent stem cell semapv:UnspecifiedMatching +ZFA:0009025 myoblast semapv:crossSpeciesExactMatch CL:0000056 myoblast semapv:UnspecifiedMatching +ZFA:0009026 fibroblast semapv:crossSpeciesExactMatch CL:0000057 fibroblast semapv:UnspecifiedMatching +ZFA:0009027 chondroblast semapv:crossSpeciesExactMatch CL:0000058 chondroblast semapv:UnspecifiedMatching +ZFA:0009029 odontoblast semapv:crossSpeciesExactMatch CL:0000060 odontoblast semapv:UnspecifiedMatching +ZFA:0009030 cementoblast semapv:crossSpeciesExactMatch CL:0000061 cementoblast semapv:UnspecifiedMatching +ZFA:0009031 osteoblast semapv:crossSpeciesExactMatch CL:0000062 osteoblast semapv:UnspecifiedMatching +ZFA:0009032 ciliated cell semapv:crossSpeciesExactMatch CL:0000064 ciliated cell semapv:UnspecifiedMatching +ZFA:0009033 ependymal cell semapv:crossSpeciesExactMatch CL:0000065 ependymal cell semapv:UnspecifiedMatching +ZFA:0009034 epithelial cell semapv:crossSpeciesExactMatch CL:0000066 epithelial cell semapv:UnspecifiedMatching +ZFA:0009035 ciliated epithelial cell semapv:crossSpeciesExactMatch CL:0000067 ciliated epithelial cell semapv:UnspecifiedMatching +ZFA:0009036 blood vessel endothelial cell semapv:crossSpeciesExactMatch CL:0000071 blood vessel endothelial cell semapv:UnspecifiedMatching +ZFA:0009038 columnar/cuboidal epithelial cell semapv:crossSpeciesExactMatch CL:0000075 columnar/cuboidal epithelial cell semapv:UnspecifiedMatching +ZFA:0009039 squamous epithelial cell semapv:crossSpeciesExactMatch CL:0000076 squamous epithelial cell semapv:UnspecifiedMatching +ZFA:0009040 mesothelial cell semapv:crossSpeciesExactMatch CL:0000077 mesothelial cell semapv:UnspecifiedMatching +ZFA:0009041 peridermal cell semapv:crossSpeciesExactMatch CL:0000078 peridermal cell semapv:UnspecifiedMatching +ZFA:0009042 stratified epithelial cell semapv:crossSpeciesExactMatch CL:0000079 stratified epithelial cell semapv:UnspecifiedMatching +ZFA:0009043 circulating cell semapv:crossSpeciesExactMatch CL:0000080 circulating cell semapv:UnspecifiedMatching +ZFA:0009044 blood cell semapv:crossSpeciesExactMatch CL:0000081 blood cell semapv:UnspecifiedMatching +ZFA:0009045 epithelial cell of pancreas semapv:crossSpeciesExactMatch CL:0000083 epithelial cell of pancreas semapv:UnspecifiedMatching +ZFA:0009046 T cell semapv:crossSpeciesExactMatch CL:0000084 T cell semapv:UnspecifiedMatching +ZFA:0009047 osteoclast semapv:crossSpeciesExactMatch CL:0000092 osteoclast semapv:UnspecifiedMatching +ZFA:0009048 granulocyte semapv:crossSpeciesExactMatch CL:0000094 granulocyte semapv:UnspecifiedMatching +ZFA:0009049 mature neutrophil semapv:crossSpeciesExactMatch CL:0000096 mature neutrophil semapv:UnspecifiedMatching +ZFA:0009050 sensory epithelial cell semapv:crossSpeciesExactMatch CL:0000098 sensory epithelial cell semapv:UnspecifiedMatching +ZFA:0009051 interneuron semapv:crossSpeciesExactMatch CL:0000099 interneuron semapv:UnspecifiedMatching +ZFA:0009052 motor neuron semapv:crossSpeciesExactMatch CL:0000100 motor neuron semapv:UnspecifiedMatching +ZFA:0009053 sensory neuron semapv:crossSpeciesExactMatch CL:0000101 sensory neuron semapv:UnspecifiedMatching +ZFA:0009054 polymodal neuron semapv:crossSpeciesExactMatch CL:0000102 polymodal neuron semapv:UnspecifiedMatching +ZFA:0009055 bipolar neuron semapv:crossSpeciesExactMatch CL:0000103 bipolar neuron semapv:UnspecifiedMatching +ZFA:0009056 multipolar neuron semapv:crossSpeciesExactMatch CL:0000104 multipolar neuron semapv:UnspecifiedMatching +ZFA:0009057 pseudounipolar neuron semapv:crossSpeciesExactMatch CL:0000105 pseudounipolar neuron semapv:UnspecifiedMatching +ZFA:0009058 unipolar neuron semapv:crossSpeciesExactMatch CL:0000106 unipolar neuron semapv:UnspecifiedMatching +ZFA:0009059 autonomic neuron semapv:crossSpeciesExactMatch CL:0000107 autonomic neuron semapv:UnspecifiedMatching +ZFA:0009060 cholinergic neuron semapv:crossSpeciesExactMatch CL:0000108 cholinergic neuron semapv:UnspecifiedMatching +ZFA:0009061 adrenergic neuron semapv:crossSpeciesExactMatch CL:0000109 adrenergic neuron semapv:UnspecifiedMatching +ZFA:0009062 peptidergic neuron semapv:crossSpeciesExactMatch CL:0000110 peptidergic neuron semapv:UnspecifiedMatching +ZFA:0009064 mononuclear phagocyte semapv:crossSpeciesExactMatch CL:0000113 mononuclear phagocyte semapv:UnspecifiedMatching +ZFA:0009065 endothelial cell semapv:crossSpeciesExactMatch CL:0000115 endothelial cell semapv:UnspecifiedMatching +ZFA:0009066 pioneer neuron semapv:crossSpeciesExactMatch CL:0000116 pioneer neuron semapv:UnspecifiedMatching +ZFA:0009067 CNS neuron (sensu Vertebrata) semapv:crossSpeciesExactMatch CL:0000117 CNS neuron (sensu Vertebrata) semapv:UnspecifiedMatching +ZFA:0009068 basket cell semapv:crossSpeciesExactMatch CL:0000118 basket cell semapv:UnspecifiedMatching +ZFA:0009069 Golgi cell semapv:crossSpeciesExactMatch CL:0000119 cerebellar Golgi cell semapv:UnspecifiedMatching +ZFA:0009070 granule cell semapv:crossSpeciesExactMatch CL:0000120 granule cell semapv:UnspecifiedMatching +ZFA:0009071 Purkinje cell semapv:crossSpeciesExactMatch CL:0000121 Purkinje cell semapv:UnspecifiedMatching +ZFA:0009072 stellate cell semapv:crossSpeciesExactMatch CL:0000122 stellate neuron semapv:UnspecifiedMatching +ZFA:0009073 glial cell semapv:crossSpeciesExactMatch CL:0000125 glial cell semapv:UnspecifiedMatching +ZFA:0009074 macroglial cell semapv:crossSpeciesExactMatch CL:0000126 macroglial cell semapv:UnspecifiedMatching +ZFA:0009075 astrocyte semapv:crossSpeciesExactMatch CL:0000127 astrocyte semapv:UnspecifiedMatching +ZFA:0009076 oligodendrocyte semapv:crossSpeciesExactMatch CL:0000128 oligodendrocyte semapv:UnspecifiedMatching +ZFA:0009077 microglial cell semapv:crossSpeciesExactMatch CL:0000129 microglial cell semapv:UnspecifiedMatching +ZFA:0009078 gut endothelial cell semapv:crossSpeciesExactMatch CL:0000131 gut endothelial cell semapv:UnspecifiedMatching +ZFA:0009079 corneal endothelial cell semapv:crossSpeciesExactMatch CL:0000132 corneal endothelial cell semapv:UnspecifiedMatching +ZFA:0009080 neurectodermal cell semapv:crossSpeciesExactMatch CL:0000133 neurectodermal cell semapv:UnspecifiedMatching +ZFA:0009081 mesenchymal cell semapv:crossSpeciesExactMatch CL:0000134 mesenchymal stem cell semapv:UnspecifiedMatching +ZFA:0009082 fat cell semapv:crossSpeciesExactMatch CL:0000136 adipocyte semapv:UnspecifiedMatching +ZFA:0009083 osteocyte semapv:crossSpeciesExactMatch CL:0000137 osteocyte semapv:UnspecifiedMatching +ZFA:0009084 chondrocyte semapv:crossSpeciesExactMatch CL:0000138 chondrocyte semapv:UnspecifiedMatching +ZFA:0009086 odontocyte semapv:crossSpeciesExactMatch CL:0000140 odontocyte semapv:UnspecifiedMatching +ZFA:0009087 cementocyte semapv:crossSpeciesExactMatch CL:0000141 cementocyte semapv:UnspecifiedMatching +ZFA:0009088 professional antigen presenting cell semapv:crossSpeciesExactMatch CL:0000145 professional antigen presenting cell semapv:UnspecifiedMatching +ZFA:0009089 simple columnar epithelial cell semapv:crossSpeciesExactMatch CL:0000146 simple columnar epithelial cell semapv:UnspecifiedMatching +ZFA:0009090 pigment cell semapv:crossSpeciesExactMatch CL:0000147 pigment cell semapv:UnspecifiedMatching +ZFA:0009091 melanocyte semapv:crossSpeciesExactMatch CL:0000148 melanocyte semapv:UnspecifiedMatching +ZFA:0009092 exocrine cell semapv:crossSpeciesExactMatch CL:0000152 exocrine cell semapv:UnspecifiedMatching +ZFA:0009093 GAG secreting cell semapv:crossSpeciesExactMatch CL:0000153 glycosaminoglycan secreting cell semapv:UnspecifiedMatching +ZFA:0009094 goblet cell semapv:crossSpeciesExactMatch CL:0000160 goblet cell semapv:UnspecifiedMatching +ZFA:0009096 endocrine cell semapv:crossSpeciesExactMatch CL:0000163 endocrine cell semapv:UnspecifiedMatching +ZFA:0009097 enteroendocrine cell semapv:crossSpeciesExactMatch CL:0000164 enteroendocrine cell semapv:UnspecifiedMatching +ZFA:0009098 neuroendocrine cell semapv:crossSpeciesExactMatch CL:0000165 neuroendocrine cell semapv:UnspecifiedMatching +ZFA:0009099 chromaffin cell semapv:crossSpeciesExactMatch CL:0000166 chromaffin cell semapv:UnspecifiedMatching +ZFA:0009100 peptide hormone secreting cell semapv:crossSpeciesExactMatch CL:0000167 peptide hormone secreting cell semapv:UnspecifiedMatching +ZFA:0009101 insulin secreting cell semapv:crossSpeciesExactMatch CL:0000168 insulin secreting cell semapv:UnspecifiedMatching +ZFA:0009102 pancreatic B cell semapv:crossSpeciesExactMatch CL:0000169 type B pancreatic cell semapv:UnspecifiedMatching +ZFA:0009103 glucagon secreting cell semapv:crossSpeciesExactMatch CL:0000170 glucagon secreting cell semapv:UnspecifiedMatching +ZFA:0009104 pancreatic A cell semapv:crossSpeciesExactMatch CL:0000171 pancreatic A cell semapv:UnspecifiedMatching +ZFA:0009105 somatostatin secreting cell semapv:crossSpeciesExactMatch CL:0000172 somatostatin secreting cell semapv:UnspecifiedMatching +ZFA:0009106 steroid hormone secreting cell semapv:crossSpeciesExactMatch CL:0000174 steroid hormone secreting cell semapv:UnspecifiedMatching +ZFA:0009107 testosterone secreting cell semapv:crossSpeciesExactMatch CL:0000177 testosterone secreting cell semapv:UnspecifiedMatching +ZFA:0009108 Leydig cell semapv:crossSpeciesExactMatch CL:0000178 Leydig cell semapv:UnspecifiedMatching +ZFA:0009109 progesterone secreting cell semapv:crossSpeciesExactMatch CL:0000179 progesterone secreting cell semapv:UnspecifiedMatching +ZFA:0009110 estradiol secreting cell semapv:crossSpeciesExactMatch CL:0000180 estradiol secreting cell semapv:UnspecifiedMatching +ZFA:0009111 hepatocyte semapv:crossSpeciesExactMatch CL:0000182 hepatocyte semapv:UnspecifiedMatching +ZFA:0009112 pericyte semapv:crossSpeciesExactMatch CL:0000669 pericyte semapv:UnspecifiedMatching +ZFA:0009113 myoepithelial cell semapv:crossSpeciesExactMatch CL:0000185 myoepithelial cell semapv:UnspecifiedMatching +ZFA:0009114 muscle cell semapv:crossSpeciesExactMatch CL:0000187 muscle cell semapv:UnspecifiedMatching +ZFA:0009115 skeletal muscle cell semapv:crossSpeciesExactMatch CL:0000188 cell of skeletal muscle semapv:UnspecifiedMatching +ZFA:0009116 slow muscle cell semapv:crossSpeciesExactMatch CL:0000189 slow muscle cell semapv:UnspecifiedMatching +ZFA:0009117 fast muscle cell semapv:crossSpeciesExactMatch CL:0000190 fast muscle cell semapv:UnspecifiedMatching +ZFA:0009118 smooth muscle cell semapv:crossSpeciesExactMatch CL:0000192 smooth muscle cell semapv:UnspecifiedMatching +ZFA:0009119 pain receptor cell semapv:crossSpeciesExactMatch CL:0000198 pain receptor cell semapv:UnspecifiedMatching +ZFA:0009120 mechanoreceptor cell semapv:crossSpeciesExactMatch CL:0000199 mechanoreceptor cell semapv:UnspecifiedMatching +ZFA:0009121 auditory receptor cell semapv:crossSpeciesExactMatch CL:0000202 auditory hair cell semapv:UnspecifiedMatching +ZFA:0009123 thermoreceptor cell semapv:crossSpeciesExactMatch CL:0000205 thermoreceptor cell semapv:UnspecifiedMatching +ZFA:0009124 chemoreceptor cell semapv:crossSpeciesExactMatch CL:0000206 chemoreceptor cell semapv:UnspecifiedMatching +ZFA:0009125 olfactory receptor cell semapv:crossSpeciesExactMatch CL:0000207 olfactory receptor cell semapv:UnspecifiedMatching +ZFA:0009126 taste receptor cell semapv:crossSpeciesExactMatch CL:0000209 taste receptor cell semapv:UnspecifiedMatching +ZFA:0009127 photoreceptor cell semapv:crossSpeciesExactMatch CL:0000210 photoreceptor cell semapv:UnspecifiedMatching +ZFA:0009128 electrically active cell semapv:crossSpeciesExactMatch CL:0000211 electrically active cell semapv:UnspecifiedMatching +ZFA:0009129 absorptive cell semapv:crossSpeciesExactMatch CL:0000212 absorptive cell semapv:UnspecifiedMatching +ZFA:0009130 lining cell semapv:crossSpeciesExactMatch CL:0000213 lining cell semapv:UnspecifiedMatching +ZFA:0009131 synovial cell semapv:crossSpeciesExactMatch CL:0000214 synovial cell semapv:UnspecifiedMatching +ZFA:0009132 barrier cell semapv:crossSpeciesExactMatch CL:0000215 barrier cell semapv:UnspecifiedMatching +ZFA:0009133 Sertoli cell semapv:crossSpeciesExactMatch CL:0000216 Sertoli cell semapv:UnspecifiedMatching +ZFA:0009134 insulating cell semapv:crossSpeciesExactMatch CL:0000217 insulating cell semapv:UnspecifiedMatching +ZFA:0009135 myelinating Schwann cell semapv:crossSpeciesExactMatch CL:0000218 myelinating Schwann cell semapv:UnspecifiedMatching +ZFA:0009136 motile cell semapv:crossSpeciesExactMatch CL:0000219 motile cell semapv:UnspecifiedMatching +ZFA:0009137 ectodermal cell semapv:crossSpeciesExactMatch CL:0000221 ectodermal cell semapv:UnspecifiedMatching +ZFA:0009138 mesodermal cell semapv:crossSpeciesExactMatch CL:0000222 mesodermal cell semapv:UnspecifiedMatching +ZFA:0009139 endodermal cell semapv:crossSpeciesExactMatch CL:0000223 endodermal cell semapv:UnspecifiedMatching +ZFA:0009140 phagocyte semapv:crossSpeciesExactMatch CL:0000234 phagocyte semapv:UnspecifiedMatching +ZFA:0009141 macrophage semapv:crossSpeciesExactMatch CL:0000235 macrophage semapv:UnspecifiedMatching +ZFA:0009142 B cell semapv:crossSpeciesExactMatch CL:0000236 B cell semapv:UnspecifiedMatching +ZFA:0009143 brush border epithelial cell semapv:crossSpeciesExactMatch CL:0000239 brush border epithelial cell semapv:UnspecifiedMatching +ZFA:0009144 stratified squamous epithelial cell semapv:crossSpeciesExactMatch CL:0000240 stratified squamous epithelial cell semapv:UnspecifiedMatching +ZFA:0009145 stratified cuboidal epithelial cell semapv:crossSpeciesExactMatch CL:0000241 stratified cuboidal epithelial cell semapv:UnspecifiedMatching +ZFA:0009146 Merkel cell semapv:crossSpeciesExactMatch CL:0000242 Merkel cell semapv:UnspecifiedMatching +ZFA:0009148 transitional epithelial cell semapv:crossSpeciesExactMatch CL:0000244 transitional epithelial cell semapv:UnspecifiedMatching +ZFA:0009149 Mauthner neuron semapv:crossSpeciesExactMatch CL:0000246 Mauthner neuron semapv:UnspecifiedMatching +ZFA:0009150 Rohon-Beard neuron semapv:crossSpeciesExactMatch CL:0000247 Rohon-Beard neuron semapv:UnspecifiedMatching +ZFA:0009151 hatching gland cell semapv:crossSpeciesExactMatch CL:0000249 hatching gland cell semapv:UnspecifiedMatching +ZFA:0009152 extramedullary cell semapv:crossSpeciesExactMatch CL:0000251 extramedullary cell semapv:UnspecifiedMatching +ZFA:0009153 eurydendroid cell semapv:crossSpeciesExactMatch CL:0000253 eurydendroid cell semapv:UnspecifiedMatching +ZFA:0009154 eye photoreceptor cell semapv:crossSpeciesExactMatch CL:0000287 eye photoreceptor cell semapv:UnspecifiedMatching +ZFA:0009155 somatotropin secreting cell semapv:crossSpeciesExactMatch CL:0000295 somatotropin secreting cell semapv:UnspecifiedMatching +ZFA:0009156 gamete semapv:crossSpeciesExactMatch CL:0000300 gamete semapv:UnspecifiedMatching +ZFA:0009157 keratin accumulating cell semapv:crossSpeciesExactMatch CL:0000311 keratin accumulating cell semapv:UnspecifiedMatching +ZFA:0009158 keratinocyte semapv:crossSpeciesExactMatch CL:0000312 keratinocyte semapv:UnspecifiedMatching +ZFA:0009159 mucus secreting cell semapv:crossSpeciesExactMatch CL:0000319 mucus secreting cell semapv:UnspecifiedMatching +ZFA:0009162 extracellular matrix secreting cell semapv:crossSpeciesExactMatch CL:0000327 extracellular matrix secreting cell semapv:UnspecifiedMatching +ZFA:0009164 oxygen accumulating cell semapv:crossSpeciesExactMatch CL:0000329 oxygen accumulating cell semapv:UnspecifiedMatching +ZFA:0009166 mesenchyme condensation cell semapv:crossSpeciesExactMatch CL:0000335 mesenchyme condensation cell semapv:UnspecifiedMatching +ZFA:0009167 adrenal medulla cell semapv:crossSpeciesExactMatch CL:0000336 adrenal medulla chromaffin cell semapv:UnspecifiedMatching +ZFA:0009169 glioblast (sensu Vertebrata) semapv:crossSpeciesExactMatch CL:0000339 glioblast (sensu Vertebrata) semapv:UnspecifiedMatching +ZFA:0009170 pigment cell (sensu Vertebrata) semapv:crossSpeciesExactMatch CL:0000342 pigment cell (sensu Vertebrata) semapv:UnspecifiedMatching +ZFA:0009171 visual pigment cell (sensu Vertebrata) semapv:crossSpeciesExactMatch CL:0000343 visual pigment cell (sensu Vertebrata) semapv:UnspecifiedMatching +ZFA:0009173 dental papilla cell semapv:crossSpeciesExactMatch CL:0000345 dental papilla cell semapv:UnspecifiedMatching +ZFA:0009174 scleral cell semapv:crossSpeciesExactMatch CL:0000347 scleral cell semapv:UnspecifiedMatching +ZFA:0009175 choroidal cell of the eye semapv:crossSpeciesExactMatch CL:0000348 choroidal cell of the eye semapv:UnspecifiedMatching +ZFA:0009176 extraembryonic cell semapv:crossSpeciesExactMatch CL:0000349 extraembryonic cell semapv:UnspecifiedMatching +ZFA:0009177 blastoderm cell semapv:crossSpeciesExactMatch CL:0000353 blastoderm cell semapv:UnspecifiedMatching +ZFA:0009178 blastemal cell semapv:crossSpeciesExactMatch CL:0000354 blastemal cell semapv:UnspecifiedMatching +ZFA:0009179 muscle stem cell semapv:crossSpeciesExactMatch CL:0000355 multi-potent skeletal muscle stem cell semapv:UnspecifiedMatching +ZFA:0009180 stratified epithelial stem cell semapv:crossSpeciesExactMatch CL:0000357 stratified epithelial stem cell semapv:UnspecifiedMatching +ZFA:0009181 vascular associated smooth muscle cell semapv:crossSpeciesExactMatch CL:0000359 vascular associated smooth muscle cell semapv:UnspecifiedMatching +ZFA:0009182 gastrula cell semapv:crossSpeciesExactMatch CL:0000361 gastrula cell semapv:UnspecifiedMatching +ZFA:0009183 epidermal cell semapv:crossSpeciesExactMatch CL:0000362 epidermal cell semapv:UnspecifiedMatching +ZFA:0009185 sensory processing neuron semapv:crossSpeciesExactMatch CL:0000379 sensory processing neuron semapv:UnspecifiedMatching +ZFA:0009187 nephrogenic mesenchyme stem cell semapv:crossSpeciesExactMatch CL:0000383 nephrogenic mesenchyme stem cell semapv:UnspecifiedMatching +ZFA:0009188 ligament cell semapv:crossSpeciesExactMatch CL:0000384 ligament cell semapv:UnspecifiedMatching +ZFA:0009189 tendon cell semapv:crossSpeciesExactMatch CL:0000388 tendon cell semapv:UnspecifiedMatching +ZFA:0009190 electrically responsive cell semapv:crossSpeciesExactMatch CL:0000393 electrically responsive cell semapv:UnspecifiedMatching +ZFA:0009191 CNS interneuron semapv:crossSpeciesExactMatch CL:0000402 CNS interneuron semapv:UnspecifiedMatching +ZFA:0009193 electrically signaling cell semapv:crossSpeciesExactMatch CL:0000404 electrically signaling cell semapv:UnspecifiedMatching +ZFA:0009194 CNS short range interneuron semapv:crossSpeciesExactMatch CL:0000406 CNS short range interneuron semapv:UnspecifiedMatching +ZFA:0009195 CNS long range interneuron semapv:crossSpeciesExactMatch CL:0000410 CNS long range interneuron semapv:UnspecifiedMatching +ZFA:0009196 hypodermal cell semapv:crossSpeciesExactMatch CL:0000411 Caenorhabditis hypodermal cell semapv:UnspecifiedMatching +ZFA:0009198 xanthophore semapv:crossSpeciesExactMatch CL:0000430 xanthophore cell semapv:UnspecifiedMatching +ZFA:0009199 iridophore semapv:crossSpeciesExactMatch CL:0000431 iridophore semapv:UnspecifiedMatching +ZFA:0009200 reticular cell semapv:crossSpeciesExactMatch CL:0000432 reticular cell semapv:UnspecifiedMatching +ZFA:0009201 alkali secreting cell semapv:crossSpeciesExactMatch CL:0000435 alkali secreting cell semapv:UnspecifiedMatching +ZFA:0009202 follicle stimulating hormone secreting cell semapv:crossSpeciesExactMatch CL:0000437 gonadtroph semapv:UnspecifiedMatching +ZFA:0009203 luteinizing hormone secreting cell semapv:crossSpeciesExactMatch CL:0000438 luteinizing hormone secreting cell semapv:UnspecifiedMatching +ZFA:0009204 prolactin secreting cell semapv:crossSpeciesExactMatch CL:0000439 prolactin secreting cell semapv:UnspecifiedMatching +ZFA:0009205 melanocyte stimulating hormone secreting cell semapv:crossSpeciesExactMatch CL:0000440 melanocyte stimulating hormone secreting cell semapv:UnspecifiedMatching +ZFA:0009206 calcitonin secreting cell semapv:crossSpeciesExactMatch CL:0000443 calcitonin secreting cell semapv:UnspecifiedMatching +ZFA:0009209 dendritic cell semapv:crossSpeciesExactMatch CL:0000451 dendritic cell semapv:UnspecifiedMatching +ZFA:0009210 thyroid hormone secreting cell semapv:crossSpeciesExactMatch CL:0000452 thyroid hormone secreting cell semapv:UnspecifiedMatching +ZFA:0009211 epinephrin secreting cell semapv:crossSpeciesExactMatch CL:0000454 epinephrine secreting cell semapv:UnspecifiedMatching +ZFA:0009212 biogenic amine secreting cell semapv:crossSpeciesExactMatch CL:0000457 biogenic amine secreting cell semapv:UnspecifiedMatching +ZFA:0009213 serotonin secreting cell semapv:crossSpeciesExactMatch CL:0000458 serotonin secreting cell semapv:UnspecifiedMatching +ZFA:0009214 norepinephrine secreting cell semapv:crossSpeciesExactMatch CL:0000459 noradrenergic cell semapv:UnspecifiedMatching +ZFA:0009215 glucocorticoid secreting cell semapv:crossSpeciesExactMatch CL:0000460 glucocorticoid secreting cell semapv:UnspecifiedMatching +ZFA:0009216 adrenocorticotropic hormone secreting cell semapv:crossSpeciesExactMatch CL:0000467 adrenocorticotropic hormone secreting cell semapv:UnspecifiedMatching +ZFA:0009217 digestive enzyme secreting cell semapv:crossSpeciesExactMatch CL:0000470 digestive enzyme secreting cell semapv:UnspecifiedMatching +ZFA:0009218 thyroid stimulating hormone secreting cell semapv:crossSpeciesExactMatch CL:0000476 thyrotroph semapv:UnspecifiedMatching +ZFA:0009219 visible light photoreceptor cell semapv:crossSpeciesExactMatch CL:0000488 visible light photoreceptor cell semapv:UnspecifiedMatching +ZFA:0009220 photopic photoreceptor cell semapv:crossSpeciesExactMatch CL:0000490 photopic photoreceptor cell semapv:UnspecifiedMatching +ZFA:0009221 UV sensitive photoreceptor cell semapv:crossSpeciesExactMatch CL:0000494 UV sensitive photoreceptor cell semapv:UnspecifiedMatching +ZFA:0009222 blue sensitive photoreceptor cell semapv:crossSpeciesExactMatch CL:0000495 blue sensitive photoreceptor cell semapv:UnspecifiedMatching +ZFA:0009223 green sensitive photoreceptor cell semapv:crossSpeciesExactMatch CL:0000496 green sensitive photoreceptor cell semapv:UnspecifiedMatching +ZFA:0009224 red sensitive photoreceptor cell semapv:crossSpeciesExactMatch CL:0000497 red sensitive photoreceptor cell semapv:UnspecifiedMatching +ZFA:0009225 inhibitory interneuron semapv:crossSpeciesExactMatch CL:0000498 inhibitory interneuron semapv:UnspecifiedMatching +ZFA:0009226 stromal cell semapv:crossSpeciesExactMatch CL:0000499 stromal cell semapv:UnspecifiedMatching +ZFA:0009227 granulosa cell semapv:crossSpeciesExactMatch CL:0000501 granulosa cell semapv:UnspecifiedMatching +ZFA:0009228 D cell semapv:crossSpeciesExactMatch CL:0000502 type D enteroendocrine cell semapv:UnspecifiedMatching +ZFA:0009229 theca cell semapv:crossSpeciesExactMatch CL:0000503 theca cell semapv:UnspecifiedMatching +ZFA:0009230 substance P secreting cell semapv:crossSpeciesExactMatch CL:0000505 substance P secreting cell semapv:UnspecifiedMatching +ZFA:0009231 enkephalin secreting cell semapv:crossSpeciesExactMatch CL:0000506 enkephalin secreting cell semapv:UnspecifiedMatching +ZFA:0009232 endorphin secreting cell semapv:crossSpeciesExactMatch CL:0000507 endorphin secreting cell semapv:UnspecifiedMatching +ZFA:0009234 cardiac muscle myoblast semapv:crossSpeciesExactMatch CL:0000513 cardiac muscle myoblast semapv:UnspecifiedMatching +ZFA:0009235 smooth muscle myoblast semapv:crossSpeciesExactMatch CL:0000514 smooth muscle myoblast semapv:UnspecifiedMatching +ZFA:0009236 skeletal muscle myoblast semapv:crossSpeciesExactMatch CL:0000515 skeletal muscle myoblast semapv:UnspecifiedMatching +ZFA:0009237 perineuronal satellite cell semapv:crossSpeciesExactMatch CL:0000516 perineuronal satellite cell semapv:UnspecifiedMatching +ZFA:0009238 afferent neuron semapv:crossSpeciesExactMatch CL:0000526 afferent neuron semapv:UnspecifiedMatching +ZFA:0009239 efferent neuron semapv:crossSpeciesExactMatch CL:0000527 efferent neuron semapv:UnspecifiedMatching +ZFA:0009240 nitrergic neuron semapv:crossSpeciesExactMatch CL:0000528 nitrergic neuron semapv:UnspecifiedMatching +ZFA:0009241 pigmented epithelial cell semapv:crossSpeciesExactMatch CL:0000529 pigmented epithelial cell semapv:UnspecifiedMatching +ZFA:0009242 primary neuron semapv:crossSpeciesExactMatch CL:0000530 primary neuron (sensu Teleostei) semapv:UnspecifiedMatching +ZFA:0009243 CaP motoneuron semapv:crossSpeciesExactMatch CL:0000532 CAP motoneuron semapv:UnspecifiedMatching +ZFA:0009244 primary motor neuron semapv:crossSpeciesExactMatch CL:0000533 primary motor neuron (sensu Teleostei) semapv:UnspecifiedMatching +ZFA:0009245 primary interneuron semapv:crossSpeciesExactMatch CL:0000534 primary interneuron (sensu Teleostei) semapv:UnspecifiedMatching +ZFA:0009246 secondary neuron semapv:crossSpeciesExactMatch CL:0000535 secondary neuron (sensu Teleostei) semapv:UnspecifiedMatching +ZFA:0009247 secondary motor neuron semapv:crossSpeciesExactMatch CL:0000536 secondary motor neuron (sensu Teleostei) semapv:UnspecifiedMatching +ZFA:0009248 neuron semapv:crossSpeciesExactMatch CL:0000540 neuron semapv:UnspecifiedMatching +ZFA:0009249 melanoblast semapv:crossSpeciesExactMatch CL:0000541 melanoblast semapv:UnspecifiedMatching +ZFA:0009250 lymphocyte semapv:crossSpeciesExactMatch CL:0000542 lymphocyte semapv:UnspecifiedMatching +ZFA:0009251 granulocyte monocyte progenitor cell semapv:crossSpeciesExactMatch CL:0000557 granulocyte monocyte progenitor cell semapv:UnspecifiedMatching +ZFA:0009252 reticulocyte semapv:crossSpeciesExactMatch CL:0000558 reticulocyte semapv:UnspecifiedMatching +ZFA:0009253 promonocyte semapv:crossSpeciesExactMatch CL:0000559 promonocyte semapv:UnspecifiedMatching +ZFA:0009254 band form neutrophil semapv:crossSpeciesExactMatch CL:0000560 band form neutrophil semapv:UnspecifiedMatching +ZFA:0009255 amacrine cell semapv:crossSpeciesExactMatch CL:0000561 amacrine cell semapv:UnspecifiedMatching +ZFA:0009256 nucleate erythrocyte semapv:crossSpeciesExactMatch CL:0000562 nucleate erythrocyte semapv:UnspecifiedMatching +ZFA:0009257 neutrophilic promyelocyte semapv:crossSpeciesExactMatch CL:0000564 neutrophilic promyelocyte semapv:UnspecifiedMatching +ZFA:0009258 angioblastic mesenchymal cell semapv:crossSpeciesExactMatch CL:0000566 angioblastic mesenchymal cell semapv:UnspecifiedMatching +ZFA:0009259 cardiac mesenchymal cell semapv:crossSpeciesExactMatch CL:0000569 cardiac mesenchymal cell semapv:UnspecifiedMatching +ZFA:0009260 parafollicular cell semapv:crossSpeciesExactMatch CL:0000570 parafollicular cell semapv:UnspecifiedMatching +ZFA:0009261 leucophore semapv:crossSpeciesExactMatch CL:0000571 leucophore semapv:UnspecifiedMatching +ZFA:0009262 retinal cone cell semapv:crossSpeciesExactMatch CL:0000573 retinal cone cell semapv:UnspecifiedMatching +ZFA:0009263 erythrophore semapv:crossSpeciesExactMatch CL:0000574 erythrophore semapv:UnspecifiedMatching +ZFA:0009264 corneal epithelial cell semapv:crossSpeciesExactMatch CL:0000575 corneal epithelial cell semapv:UnspecifiedMatching +ZFA:0009265 monocyte semapv:crossSpeciesExactMatch CL:0000576 monocyte semapv:UnspecifiedMatching +ZFA:0009266 neutrophilic myelocyte semapv:crossSpeciesExactMatch CL:0000580 neutrophilic myelocyte semapv:UnspecifiedMatching +ZFA:0009267 peritoneal macrophage semapv:crossSpeciesExactMatch CL:0000581 peritoneal macrophage semapv:UnspecifiedMatching +ZFA:0009268 neutrophilic metamyelocyte semapv:crossSpeciesExactMatch CL:0000582 neutrophilic metamyelocyte semapv:UnspecifiedMatching +ZFA:0009269 enterocyte semapv:crossSpeciesExactMatch CL:0000584 enterocyte semapv:UnspecifiedMatching +ZFA:0009270 odontoclast semapv:crossSpeciesExactMatch CL:0000588 odontoclast semapv:UnspecifiedMatching +ZFA:0009271 androgen secreting cell semapv:crossSpeciesExactMatch CL:0000593 androgen secreting cell semapv:UnspecifiedMatching +ZFA:0009272 skeletal muscle satellite cell semapv:crossSpeciesExactMatch CL:0000594 skeletal muscle satellite cell semapv:UnspecifiedMatching +ZFA:0009273 pyramidal cell semapv:crossSpeciesExactMatch CL:0000598 pyramidal neuron semapv:UnspecifiedMatching +ZFA:0009274 pressoreceptor cell semapv:crossSpeciesExactMatch CL:0000602 pressoreceptor cell semapv:UnspecifiedMatching +ZFA:0009275 retinal rod cell semapv:crossSpeciesExactMatch CL:0000604 retinal rod cell semapv:UnspecifiedMatching +ZFA:0009276 GABAergic neuron semapv:crossSpeciesExactMatch CL:0000617 GABAergic neuron semapv:UnspecifiedMatching +ZFA:0009277 acinar cell semapv:crossSpeciesExactMatch CL:0000622 acinar cell semapv:UnspecifiedMatching +ZFA:0009278 natural killer cell semapv:crossSpeciesExactMatch CL:0000623 natural killer cell semapv:UnspecifiedMatching +ZFA:0009279 ito cell semapv:crossSpeciesExactMatch CL:0000632 hepatic stellate cell semapv:UnspecifiedMatching +ZFA:0009280 Muller cell semapv:crossSpeciesExactMatch CL:0000636 Mueller cell semapv:UnspecifiedMatching +ZFA:0009281 folliculostellate cell semapv:crossSpeciesExactMatch CL:0000642 folliculostellate cell semapv:UnspecifiedMatching +ZFA:0009282 Bergmann glial cell semapv:crossSpeciesExactMatch CL:0000644 Bergmann glial cell semapv:UnspecifiedMatching +ZFA:0009283 mesangial cell semapv:crossSpeciesExactMatch CL:0000650 mesangial cell semapv:UnspecifiedMatching +ZFA:0009284 pinealocyte semapv:crossSpeciesExactMatch CL:0000652 pinealocyte semapv:UnspecifiedMatching +ZFA:0009285 podocyte semapv:crossSpeciesExactMatch CL:0000653 podocyte semapv:UnspecifiedMatching +ZFA:0009286 fenestrated cell semapv:crossSpeciesExactMatch CL:0000666 fenestrated endothelial cell semapv:UnspecifiedMatching +ZFA:0009287 collagen secreting cell semapv:crossSpeciesExactMatch CL:0000667 collagen secreting cell semapv:UnspecifiedMatching +ZFA:0009288 primordial germ cell semapv:crossSpeciesExactMatch CL:0000670 primordial germ cell semapv:UnspecifiedMatching +ZFA:0009289 gut absorptive cell semapv:crossSpeciesExactMatch CL:0000677 gut absorptive cell semapv:UnspecifiedMatching +ZFA:0009290 glutamatergic neuron semapv:crossSpeciesExactMatch CL:0000679 glutamatergic neuron semapv:UnspecifiedMatching +ZFA:0009291 muscle precursor cell semapv:crossSpeciesExactMatch CL:0000680 muscle precursor cell semapv:UnspecifiedMatching +ZFA:0009292 radial glial cell semapv:crossSpeciesExactMatch CL:0000681 radial glial cell semapv:UnspecifiedMatching +ZFA:0009293 M cell semapv:crossSpeciesExactMatch CL:0000682 M cell of gut semapv:UnspecifiedMatching +ZFA:0009294 ependymoglial cell semapv:crossSpeciesExactMatch CL:0000683 ependymoglial cell semapv:UnspecifiedMatching +ZFA:0009295 cerebrospinal fluid secreting cell semapv:crossSpeciesExactMatch CL:0000686 cerebrospinal fluid secreting cell semapv:UnspecifiedMatching +ZFA:0009296 perijunctional fibroblast semapv:crossSpeciesExactMatch CL:0000688 perijunctional fibroblast semapv:UnspecifiedMatching +ZFA:0009297 stellate interneuron semapv:crossSpeciesExactMatch CL:0000691 stellate interneuron semapv:UnspecifiedMatching +ZFA:0009298 terminal Schwann cell semapv:crossSpeciesExactMatch CL:0000692 terminal Schwann cell semapv:UnspecifiedMatching +ZFA:0009299 neuroglioform cell semapv:crossSpeciesExactMatch CL:0000693 neurogliaform cell semapv:UnspecifiedMatching +ZFA:0009300 Cajal-Retzius cell semapv:crossSpeciesExactMatch CL:0000695 Cajal-Retzius cell semapv:UnspecifiedMatching +ZFA:0009301 dopaminergic neuron semapv:crossSpeciesExactMatch CL:0000700 dopaminergic neuron semapv:UnspecifiedMatching +ZFA:0009302 sustentacular cell semapv:crossSpeciesExactMatch CL:0000703 sustentacular cell semapv:UnspecifiedMatching +ZFA:0009303 endothelial tip cell semapv:crossSpeciesExactMatch CL:0000704 endothelial tip cell semapv:UnspecifiedMatching +ZFA:0009304 choroid plexus epithelial cell semapv:crossSpeciesExactMatch CL:0000706 choroid plexus epithelial cell semapv:UnspecifiedMatching +ZFA:0009305 leptomeningeal cell semapv:crossSpeciesExactMatch CL:0000708 leptomeningeal cell semapv:UnspecifiedMatching +ZFA:0009307 somatic stem cell semapv:crossSpeciesExactMatch CL:0000723 somatic stem cell semapv:UnspecifiedMatching +ZFA:0009308 urothelial cell semapv:crossSpeciesExactMatch CL:0000731 urothelial cell semapv:UnspecifiedMatching +ZFA:0009309 leukocyte semapv:crossSpeciesExactMatch CL:0000738 leukocyte semapv:UnspecifiedMatching +ZFA:0009310 retinal ganglion cell semapv:crossSpeciesExactMatch CL:0000740 retinal ganglion cell semapv:UnspecifiedMatching +ZFA:0009311 spinal accessory motor neuron semapv:crossSpeciesExactMatch CL:0000741 spinal accessory motor neuron semapv:UnspecifiedMatching +ZFA:0009312 periarticular chondrocyte semapv:crossSpeciesExactMatch CL:0000742 periarticular chondrocyte semapv:UnspecifiedMatching +ZFA:0009313 hypertrophic chondrocyte semapv:crossSpeciesExactMatch CL:0000743 hypertrophic chondrocyte semapv:UnspecifiedMatching +ZFA:0009314 columnar chondrocyte semapv:crossSpeciesExactMatch CL:0000744 columnar chondrocyte semapv:UnspecifiedMatching +ZFA:0009315 horizontal cell semapv:crossSpeciesExactMatch CL:0000745 retina horizontal cell semapv:UnspecifiedMatching +ZFA:0009316 cardiac muscle cell semapv:crossSpeciesExactMatch CL:0000746 cardiac muscle cell semapv:UnspecifiedMatching +ZFA:0009317 cyanophore semapv:crossSpeciesExactMatch CL:0000747 cyanophore semapv:UnspecifiedMatching +ZFA:0009318 retinal bipolar neuron semapv:crossSpeciesExactMatch CL:0000748 retinal bipolar neuron semapv:UnspecifiedMatching +ZFA:0009319 ON-bipolar cell semapv:crossSpeciesExactMatch CL:0000749 ON-bipolar cell semapv:UnspecifiedMatching +ZFA:0009320 OFF-bipolar cell semapv:crossSpeciesExactMatch CL:0000750 OFF-bipolar cell semapv:UnspecifiedMatching +ZFA:0009321 rod bipolar cell semapv:crossSpeciesExactMatch CL:0000751 rod bipolar cell semapv:UnspecifiedMatching +ZFA:0009322 cone retinal bipolar cell semapv:crossSpeciesExactMatch CL:0000752 cone retinal bipolar cell semapv:UnspecifiedMatching +ZFA:0009323 thrombocyte semapv:crossSpeciesExactMatch CL:0000762 nucleated thrombocyte semapv:UnspecifiedMatching +ZFA:0009324 myeloid cell semapv:crossSpeciesExactMatch CL:0000763 myeloid cell semapv:UnspecifiedMatching +ZFA:0009325 erythroid lineage cell semapv:crossSpeciesExactMatch CL:0000764 erythroid lineage cell semapv:UnspecifiedMatching +ZFA:0009326 myeloid leukocyte semapv:crossSpeciesExactMatch CL:0000766 myeloid leukocyte semapv:UnspecifiedMatching +ZFA:0009327 neutrophil semapv:crossSpeciesExactMatch CL:0000775 neutrophil semapv:UnspecifiedMatching +ZFA:0009328 immature neutrophil semapv:crossSpeciesExactMatch CL:0000776 immature neutrophil semapv:UnspecifiedMatching +ZFA:0009329 mononuclear osteoclast semapv:crossSpeciesExactMatch CL:0000778 mononuclear osteoclast semapv:UnspecifiedMatching +ZFA:0009330 mononuclear odontoclast semapv:crossSpeciesExactMatch CL:0000781 mononuclear odontoclast semapv:UnspecifiedMatching +ZFA:0009331 mature B cell semapv:crossSpeciesExactMatch CL:0000785 mature B cell semapv:UnspecifiedMatching +ZFA:0009332 plasma cell semapv:crossSpeciesExactMatch CL:0000786 plasma cell semapv:UnspecifiedMatching +ZFA:0009333 memory B cell semapv:crossSpeciesExactMatch CL:0000787 memory B cell semapv:UnspecifiedMatching +ZFA:0009334 naive B cell semapv:crossSpeciesExactMatch CL:0000788 naive B cell semapv:UnspecifiedMatching +ZFA:0009335 alpha-beta T cell semapv:crossSpeciesExactMatch CL:0000789 alpha-beta T cell semapv:UnspecifiedMatching +ZFA:0009336 gamma-delta T cell semapv:crossSpeciesExactMatch CL:0000798 gamma-delta T cell semapv:UnspecifiedMatching +ZFA:0009337 immature gamma-delta T cell semapv:crossSpeciesExactMatch CL:0000799 immature gamma-delta T cell semapv:UnspecifiedMatching +ZFA:0009338 mature gamma-delta T cell semapv:crossSpeciesExactMatch CL:0000800 mature gamma-delta T cell semapv:UnspecifiedMatching +ZFA:0009339 gamma-delta intraepithelial T cell semapv:crossSpeciesExactMatch CL:0000801 gamma-delta intraepithelial T cell semapv:UnspecifiedMatching +ZFA:0009342 memory T cell semapv:crossSpeciesExactMatch CL:0000813 memory T cell semapv:UnspecifiedMatching +ZFA:0009343 immature B cell semapv:crossSpeciesExactMatch CL:0000816 immature B cell semapv:UnspecifiedMatching +ZFA:0009344 precursor B cell semapv:crossSpeciesExactMatch CL:0000817 precursor B cell semapv:UnspecifiedMatching +ZFA:0009345 transitional stage B cell semapv:crossSpeciesExactMatch CL:0000818 transitional stage B cell semapv:UnspecifiedMatching +ZFA:0009346 immature natural killer cell semapv:crossSpeciesExactMatch CL:0000823 immature natural killer cell semapv:UnspecifiedMatching +ZFA:0009347 mature natural killer cell semapv:crossSpeciesExactMatch CL:0000824 mature natural killer cell semapv:UnspecifiedMatching +ZFA:0009348 pro-NK cell semapv:crossSpeciesExactMatch CL:0000825 pro-NK cell semapv:UnspecifiedMatching +ZFA:0009349 pro-B cell semapv:crossSpeciesExactMatch CL:0000826 pro-B cell semapv:UnspecifiedMatching +ZFA:0009350 pro-T cell semapv:crossSpeciesExactMatch CL:0000827 pro-T cell semapv:UnspecifiedMatching +ZFA:0009351 thromboblast semapv:crossSpeciesExactMatch CL:0000828 thromboblast semapv:UnspecifiedMatching +ZFA:0009352 neutrophil progenitor cell semapv:crossSpeciesExactMatch CL:0000834 neutrophil progenitor cell semapv:UnspecifiedMatching +ZFA:0009353 myeloblast semapv:crossSpeciesExactMatch CL:0000835 myeloblast semapv:UnspecifiedMatching +ZFA:0009354 hematopoietic multipotent progenitor cell semapv:crossSpeciesExactMatch CL:0000837 hematopoietic multipotent progenitor cell semapv:UnspecifiedMatching +ZFA:0009355 lymphoid progenitor cell semapv:crossSpeciesExactMatch CL:0000838 lymphoid lineage restricted progenitor cell semapv:UnspecifiedMatching +ZFA:0009356 myeloid lineage restricted progenitor cell semapv:crossSpeciesExactMatch CL:0000839 myeloid lineage restricted progenitor cell semapv:UnspecifiedMatching +ZFA:0009357 mononuclear cell semapv:crossSpeciesExactMatch CL:0000842 mononuclear cell semapv:UnspecifiedMatching +ZFA:0009358 ciliated olfactory receptor neuron semapv:crossSpeciesExactMatch CL:0000847 ciliated olfactory receptor neuron semapv:UnspecifiedMatching +ZFA:0009359 microvillous olfactory receptor neuron semapv:crossSpeciesExactMatch CL:0000848 microvillous olfactory receptor neuron semapv:UnspecifiedMatching +ZFA:0009360 crypt olfactory receptor neuron semapv:crossSpeciesExactMatch CL:0000849 crypt olfactory receptor neuron semapv:UnspecifiedMatching +ZFA:0009361 serotonergic neuron semapv:crossSpeciesExactMatch CL:0000850 serotonergic neuron semapv:UnspecifiedMatching +ZFA:0009362 neuromast mantle cell semapv:crossSpeciesExactMatch CL:0000851 neuromast mantle cell semapv:UnspecifiedMatching +ZFA:0009363 neuromast support cell semapv:crossSpeciesExactMatch CL:0000852 neuromast supporting cell semapv:UnspecifiedMatching +ZFA:0009364 olfactory epithelial support cell semapv:crossSpeciesExactMatch CL:0000853 olfactory epithelial supporting cell semapv:UnspecifiedMatching +ZFA:0009365 interneuromast cell semapv:crossSpeciesExactMatch CL:0000854 interneuromast cell semapv:UnspecifiedMatching +ZFA:0009366 hair cell semapv:crossSpeciesExactMatch CL:0000855 sensory hair cell semapv:UnspecifiedMatching +ZFA:0009367 neuromast hair cell semapv:crossSpeciesExactMatch CL:0000856 neuromast hair cell semapv:UnspecifiedMatching +ZFA:0009368 slow muscle myoblast semapv:crossSpeciesExactMatch CL:0000857 slow muscle myoblast semapv:UnspecifiedMatching +ZFA:0009369 fast muscle myoblast semapv:crossSpeciesExactMatch CL:0000858 fast muscle myoblast semapv:UnspecifiedMatching +ZFA:0009370 stretch receptor cell semapv:crossSpeciesExactMatch CL:1000082 stretch receptor cell semapv:UnspecifiedMatching +ZFA:0009371 stratified keratinized epithelial stem cell semapv:crossSpeciesExactMatch CL:1000083 stratified keratinized epithelial stem cell semapv:UnspecifiedMatching +ZFA:0009372 duct epithelial cell semapv:crossSpeciesExactMatch CL:0000068 duct epithelial cell semapv:UnspecifiedMatching +ZFA:0009374 kidney epithelial cell semapv:crossSpeciesExactMatch CL:0002518 kidney epithelial cell semapv:UnspecifiedMatching +ZFA:0009375 renal intercalated cell semapv:crossSpeciesExactMatch CL:0005010 renal intercalated cell semapv:UnspecifiedMatching +ZFA:0009376 renal alpha-intercalated cell semapv:crossSpeciesExactMatch CL:0005011 renal alpha-intercalated cell semapv:UnspecifiedMatching +ZFA:0009379 intrahepatic bile duct epithelial cell semapv:crossSpeciesExactMatch CL:0002538 intrahepatic cholangiocyte semapv:UnspecifiedMatching +ZFA:0009380 pancreatic ductal cell semapv:crossSpeciesExactMatch CL:0002079 pancreatic ductal cell semapv:UnspecifiedMatching +ZFA:0009383 endo-epithelial cell semapv:crossSpeciesExactMatch CL:0002076 endo-epithelial cell semapv:UnspecifiedMatching +ZFA:0009385 ecto-epithelial cell semapv:crossSpeciesExactMatch CL:0002077 ecto-epithelial cell semapv:UnspecifiedMatching +ZFA:0009387 supportive cell semapv:crossSpeciesExactMatch CL:0000630 supporting cell semapv:UnspecifiedMatching +ZFA:0009388 meso-epithelial cell semapv:crossSpeciesExactMatch CL:0002078 meso-epithelial cell semapv:UnspecifiedMatching +ZFA:0009389 kidney cell semapv:crossSpeciesExactMatch CL:1000497 kidney cell semapv:UnspecifiedMatching +ZFA:0009390 kidney interstitial cell semapv:crossSpeciesExactMatch CL:1000500 kidney interstitial cell semapv:UnspecifiedMatching +ZFA:0009391 kidney medulla cell semapv:crossSpeciesExactMatch CL:1000504 kidney medulla cell semapv:UnspecifiedMatching +ZFA:0009392 connective tissue cell semapv:crossSpeciesExactMatch CL:0002320 connective tissue cell semapv:UnspecifiedMatching +ZFA:0009393 lymphangioblast semapv:crossSpeciesExactMatch CL:0005020 lymphangioblast semapv:UnspecifiedMatching +ZFA:0009394 mesenchymal lymphangioblast semapv:crossSpeciesExactMatch CL:0005021 mesenchymal lymphangioblast semapv:UnspecifiedMatching +ZFA:0009395 vascular lymphangioblast semapv:crossSpeciesExactMatch CL:0005022 vascular lymphangioblast semapv:UnspecifiedMatching +ZFA:0009396 glycinergic neuron semapv:crossSpeciesExactMatch CL:1001509 glycinergic neuron semapv:UnspecifiedMatching +ZFA:0009397 cholangiocyte semapv:crossSpeciesExactMatch CL:1000488 cholangiocyte semapv:UnspecifiedMatching +ZFA:0009399 intestinal epithelial cell semapv:crossSpeciesExactMatch CL:0002563 intestinal epithelial cell semapv:UnspecifiedMatching +ZFA:0009400 epithelial cell of esophagus semapv:crossSpeciesExactMatch CL:0002252 epithelial cell of esophagus semapv:UnspecifiedMatching +ZFA:0009401 lens fiber cell semapv:crossSpeciesExactMatch CL:0011004 lens fiber cell semapv:UnspecifiedMatching +ZFA:0009402 heart valve cell semapv:crossSpeciesExactMatch CL:1000147 cardiac valve cell semapv:UnspecifiedMatching diff --git a/src/ontology/cl-edit.owl b/src/ontology/cl-edit.owl index e83dc3240..0b434b106 100644 --- a/src/ontology/cl-edit.owl +++ b/src/ontology/cl-edit.owl @@ -3155,6 +3155,7 @@ Declaration(Class(obo:GO_0050893)) Declaration(Class(obo:GO_0070278)) Declaration(Class(obo:GO_0070483)) Declaration(Class(obo:GO_0097729)) +Declaration(Class(obo:GO_0098535)) Declaration(Class(obo:GO_0098594)) Declaration(Class(obo:GO_1990573)) Declaration(Class(obo:NCBITaxon_4896)) @@ -5362,7 +5363,6 @@ SubClassOf(obo:CL_0000182 obo:CL_0000417) SubClassOf(obo:CL_0000182 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002107)) SubClassOf(obo:CL_0000182 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0005026)) SubClassOf(obo:CL_0000182 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0006699)) -SubClassOf(obo:CL_0000182 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0044237)) SubClassOf(obo:CL_0000182 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0098754)) # Class: obo:CL_0000183 (contractile cell) @@ -31869,6 +31869,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:31558434") Annotation(ob AnnotationAssertion(rdfs:label obo:CL_4033044 "deuterosomal cell") SubClassOf(obo:CL_4033044 obo:CL_0000066) SubClassOf(obo:CL_4033044 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0004802)) +SubClassOf(obo:CL_4033044 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0098535)) # Class: obo:CL_4033045 (lung migratory dendritic cell) diff --git a/src/ontology/imports/go_terms.txt b/src/ontology/imports/go_terms.txt index 3d85cc7dc..02b058b26 100644 --- a/src/ontology/imports/go_terms.txt +++ b/src/ontology/imports/go_terms.txt @@ -16,4 +16,5 @@ GO:0045428 GO:0005927 GO:0050893 GO:0001552 -GO:0019626 \ No newline at end of file +GO:0019626 +GO:0098535 \ No newline at end of file diff --git a/src/ontology/imports/merged_import.owl b/src/ontology/imports/merged_import.owl index 2e4639e1a..047fc66c1 100644 --- a/src/ontology/imports/merged_import.owl +++ b/src/ontology/imports/merged_import.owl @@ -7,8 +7,8 @@ Prefix(rdfs:=) Ontology( - -Annotation(owl:versionInfo "2024-11-07") + +Annotation(owl:versionInfo "2024-11-19") Declaration(Class()) Declaration(Class()) @@ -45,7 +45,6 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) -Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -76,7 +75,6 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) -Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -111,7 +109,6 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) -Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -121,6 +118,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -138,7 +136,6 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) -Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -668,7 +665,6 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) -Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -691,15 +687,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) -Declaration(Class()) -Declaration(Class()) -Declaration(Class()) -Declaration(Class()) Declaration(Class()) -Declaration(Class()) -Declaration(Class()) -Declaration(Class()) -Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1443,9 +1431,6 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) -Declaration(Class()) -Declaration(Class()) -Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1455,8 +1440,6 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) -Declaration(Class()) -Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1524,7 +1507,6 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) -Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1536,6 +1518,8 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1583,10 +1567,6 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) -Declaration(Class()) -Declaration(Class()) -Declaration(Class()) -Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -1623,6 +1603,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -2283,6 +2264,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -2304,6 +2286,8 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -2358,7 +2342,6 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) -Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -2389,6 +2372,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -2763,8 +2747,6 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) -Declaration(Class()) -Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -2816,6 +2798,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -2849,15 +2832,6 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) -Declaration(Class()) -Declaration(Class()) -Declaration(Class()) -Declaration(Class()) -Declaration(Class()) -Declaration(Class()) -Declaration(Class()) -Declaration(Class()) -Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -2906,7 +2880,6 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) -Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -2916,6 +2889,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -3199,9 +3173,6 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) -Declaration(Class()) -Declaration(Class()) -Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -3477,6 +3448,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -3701,7 +3673,6 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) -Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -3824,14 +3795,11 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) -Declaration(Class()) -Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) -Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -3853,7 +3821,6 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) -Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -3900,10 +3867,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) -Declaration(Class()) Declaration(Class()) -Declaration(Class()) -Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4155,8 +4119,6 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) -Declaration(Class()) -Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4183,7 +4145,6 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) -Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4222,6 +4183,9 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4563,7 +4527,6 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) -Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4724,8 +4687,6 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) -Declaration(Class()) -Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4810,6 +4771,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -4877,6 +4839,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -5575,6 +5538,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -6277,6 +6241,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -6285,7 +6250,9 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) -Declaration(Class()) +Declaration(Class()) +Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -6580,7 +6547,6 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) -Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -6628,7 +6594,6 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) -Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -6668,6 +6633,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -6712,9 +6678,6 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) -Declaration(Class()) -Declaration(Class()) -Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -7034,8 +6997,6 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) -Declaration(Class()) -Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -7290,7 +7251,6 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) -Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -7459,6 +7419,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -7576,6 +7537,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -7603,7 +7565,6 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) -Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -7699,12 +7660,9 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) -Declaration(Class()) -Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) -Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -7819,9 +7777,6 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) -Declaration(Class()) -Declaration(Class()) -Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -7945,9 +7900,6 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) -Declaration(Class()) -Declaration(Class()) -Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -7979,7 +7931,6 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) -Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -8769,7 +8720,7 @@ Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) -Declaration(Class()) +Declaration(Class()) Declaration(Class()) Declaration(Class()) Declaration(Class()) @@ -14315,7 +14266,6 @@ Declaration(AnnotationProperty()) Declaration(AnnotationProperty()) Declaration(AnnotationProperty()) -Declaration(AnnotationProperty()) Declaration(AnnotationProperty()) Declaration(AnnotationProperty()) Declaration(AnnotationProperty()) @@ -14830,10 +14780,6 @@ AnnotationAssertion(rdfs:label "consider") -# Annotation Property: (has_alternative_id) - -AnnotationAssertion(rdfs:label "has_alternative_id") - # Annotation Property: (has_broad_synonym) AnnotationAssertion( "An alternative label for a class or property which has a more general meaning than the preferred name/primary label.") @@ -14844,7 +14790,11 @@ AnnotationAssertion(rdfs:seeAlso (database_cross_reference) +AnnotationAssertion( "An annotation property that links an ontology entity or a statement to a prefixed identifier or URI.") +AnnotationAssertion( ) +AnnotationAssertion( ) AnnotationAssertion(rdfs:label "database_cross_reference") +AnnotationAssertion(rdfs:label "has cross-reference") # Annotation Property: (has exact synonym) @@ -16633,7 +16583,6 @@ AnnotationAssertion( "results_in_organization_of") AnnotationAssertion( "results_in_organization_of") AnnotationAssertion(rdfs:label "results in organization of") -SubObjectPropertyOf( ) SubObjectPropertyOf( ) # Object Property: (causal relation between material entity and a process) @@ -17141,7 +17090,6 @@ EquivalentClasses( ObjectIntersection # Class: (mitotic sister chromatid segregation) AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:jl") "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.") -AnnotationAssertion( "GO:0016359") AnnotationAssertion( "mitotic chromosome segregation") AnnotationAssertion( "mitotic sister-chromatid adhesion release") AnnotationAssertion( "biological_process") @@ -17165,29 +17113,6 @@ AnnotationAssertion( "L-histidine biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -# Class: (negative regulation of transcription by RNA polymerase II) - -AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "GOC:txnOH") "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.") -AnnotationAssertion( "GO:0010553") -AnnotationAssertion( "GO:0045816") -AnnotationAssertion( "down regulation of transcription from RNA polymerase II promoter") -AnnotationAssertion( "down-regulation of transcription from RNA polymerase II promoter") -AnnotationAssertion( "downregulation of transcription from RNA polymerase II promoter") -AnnotationAssertion( "inhibition of transcription from RNA polymerase II promoter") -AnnotationAssertion( "negative regulation of transcription from Pol II promoter") -AnnotationAssertion( "negative regulation of transcription from RNA polymerase II promoter") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "down regulation of global transcription from RNA polymerase II promoter") -AnnotationAssertion( "down-regulation of global transcription from RNA polymerase II promoter") -AnnotationAssertion( "downregulation of global transcription from RNA polymerase II promoter") -AnnotationAssertion( "inhibition of global transcription from RNA polymerase II promoter") -AnnotationAssertion( "negative regulation of gene-specific transcription from RNA polymerase II promoter") -AnnotationAssertion( "negative regulation of global transcription from Pol II promoter") -AnnotationAssertion( "negative regulation of transcription from RNA polymerase II promoter, global") -AnnotationAssertion( "GO:0000122") -AnnotationAssertion(rdfs:label "negative regulation of transcription by RNA polymerase II") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) - # Class: (Golgi membrane) AnnotationAssertion(Annotation( "GOC:mah") "The lipid bilayer surrounding any of the compartments of the Golgi apparatus.") @@ -17203,7 +17128,6 @@ SubClassOf( "PMID:29716949") "A motor activity that generates movement along a microfilament, driven by ATP hydrolysis.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/20877"^^xsd:anyURI) -AnnotationAssertion( "GO:0030898") AnnotationAssertion( "EC:5.6.1.8") AnnotationAssertion(Annotation(rdfs:label "SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane") "Reactome:R-HSA-2316352") AnnotationAssertion(Annotation(rdfs:label "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane") "Reactome:R-HSA-432237") @@ -17263,7 +17187,6 @@ EquivalentClasses( ObjectIntersection # Class: (polysaccharide catabolic process) AnnotationAssertion(Annotation( "PMID:33139480") "The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.") -AnnotationAssertion( "GO:0044244") AnnotationAssertion( "polysaccharide breakdown") AnnotationAssertion( "polysaccharide catabolism") AnnotationAssertion( "polysaccharide degradation") @@ -17276,7 +17199,6 @@ EquivalentClasses( ObjectIntersection # Class: (mitotic cell cycle) AnnotationAssertion(Annotation( "GOC:mah") Annotation( "ISBN:0815316194") "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.") -AnnotationAssertion( "GO:0007067") AnnotationAssertion( "Wikipedia:Mitosis") AnnotationAssertion( "biological_process") AnnotationAssertion( "mitosis") @@ -17358,7 +17280,6 @@ EquivalentClasses( ObjectIntersection # Class: (karyogamy) AnnotationAssertion(Annotation( "GOC:elh") "The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei.") -AnnotationAssertion( "GO:0007335") AnnotationAssertion( "Wikipedia:Karyogamy") AnnotationAssertion( "nuclear fusion") AnnotationAssertion( "nuclear fusion during karyogamy") @@ -17382,9 +17303,6 @@ SubClassOf( "GOC:elh") Annotation( "PMID:20404130") "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/28301"^^xsd:anyURI) -AnnotationAssertion( "GO:0000789") -AnnotationAssertion( "GO:0000790") -AnnotationAssertion( "GO:0005717") AnnotationAssertion( "NIF_Subcellular:sao1615953555") AnnotationAssertion( "cytoplasmic chromatin") AnnotationAssertion( "nuclear chromatin") @@ -17400,8 +17318,6 @@ SubClassOf( ObjectSomeValuesFrom( "PMID:32017156") "A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/22355"^^xsd:anyURI) -AnnotationAssertion( "GO:0005719") -AnnotationAssertion( "GO:0035327") AnnotationAssertion( "NIF_Subcellular:sao445485807") AnnotationAssertion( "Wikipedia:Euchromatin") AnnotationAssertion( "transcriptionally active chromatin") @@ -17415,8 +17331,6 @@ SubClassOf( "PMID:32017156") "A compact and highly condensed form of chromatin that is refractory to transcription.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/22355"^^xsd:anyURI) -AnnotationAssertion( "GO:0005720") -AnnotationAssertion( "GO:0035328") AnnotationAssertion( "NIF_Subcellular:sao581845896") AnnotationAssertion( "Wikipedia:Heterochromatin") AnnotationAssertion( "transcriptionally inactive chromatin") @@ -17450,9 +17364,6 @@ SubClassOf( (cell morphogenesis) AnnotationAssertion(Annotation( "GOC:clt") Annotation( "GOC:dph") Annotation( "GOC:go_curators") Annotation( "GOC:tb") "The developmental process in which the size or shape of a cell is generated and organized.") -AnnotationAssertion( "GO:0007148") -AnnotationAssertion( "GO:0045790") -AnnotationAssertion( "GO:0045791") AnnotationAssertion( "cellular morphogenesis") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0000902") @@ -17462,102 +17373,6 @@ AnnotationAssertion( "cell morphogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -# Class: (transcription cis-regulatory region binding) - -AnnotationAssertion(Annotation( "GOC:txnOH") "Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.") -AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/19312"^^xsd:anyURI) -AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/20791"^^xsd:anyURI) -AnnotationAssertion( "krc") -AnnotationAssertion( "2010-08-10T02:58:18Z") -AnnotationAssertion( "GO:0000975") -AnnotationAssertion( "GO:0000984") -AnnotationAssertion( "GO:0001017") -AnnotationAssertion( "GO:0044212") -AnnotationAssertion( "regulatory region DNA binding") -AnnotationAssertion( "transcription regulatory region sequence-specific DNA binding") -AnnotationAssertion( "bacterial-type RNA polymerase regulatory region DNA binding") -AnnotationAssertion( "bacterial-type RNA polymerase transcription regulatory region sequence-specific DNA binding") -AnnotationAssertion( "eubacterial-type RNA polymerase regulatory region DNA binding") -AnnotationAssertion( "eubacterial-type RNA polymerase regulatory region sequence-specific DNA binding") -AnnotationAssertion( "molecular_function") -AnnotationAssertion( "transcription regulatory region DNA binding") -AnnotationAssertion( "GO:0000976") -AnnotationAssertion(rdfs:comment "Note that this term is meant to also capture non-specific binding to regulatory regions. Also, to minimize ambiguity in the use of the word \"promoter\" in GO, we have chosen the phrase \"transcription regulatory region\" to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the \"core promoter\" where the basal transcription machinery binds, the \"core promoter proximal region\" where regulatory factors other than the basal machinery bind. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription.") -AnnotationAssertion(rdfs:label "transcription cis-regulatory region binding") -SubClassOf( ) -SubClassOf( ) -SubClassOf( ) - -# Class: (RNA polymerase II transcription regulatory region sequence-specific DNA binding) - -AnnotationAssertion(Annotation( "GOC:txnOH") "Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.") -AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/19312"^^xsd:anyURI) -AnnotationAssertion( "krc") -AnnotationAssertion( "2010-08-10T11:05:36Z") -AnnotationAssertion( "GO:0001012") -AnnotationAssertion( "molecular_function") -AnnotationAssertion( "RNA polymerase II regulatory region DNA binding") -AnnotationAssertion( "GO:0000977") -AnnotationAssertion(rdfs:comment "To minimize ambiguity in the use of the word \"promoter\" in GO, we have chosen the phrase \"transcription regulatory region\" to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the \"core promoter\" where the basal transcription machinery binds, the \"core promoter proximal region\" where regulatory factors other than the basal machinery bind. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription.") -AnnotationAssertion(rdfs:label "RNA polymerase II transcription regulatory region sequence-specific DNA binding") -SubClassOf( ) - -# Class: (DNA-binding transcription factor activity, RNA polymerase II-specific) - -AnnotationAssertion(Annotation( "GOC:txnOH-2018") "A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.") -AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/15530"^^xsd:anyURI) -AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/16131"^^xsd:anyURI) -AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/16152"^^xsd:anyURI) -AnnotationAssertion( "krc") -AnnotationAssertion( "2010-08-10T02:37:21Z") -AnnotationAssertion( "GO:0000982") -AnnotationAssertion( "GO:0001133") -AnnotationAssertion( "GO:0001200") -AnnotationAssertion( "GO:0001201") -AnnotationAssertion( "GO:0001202") -AnnotationAssertion( "GO:0001203") -AnnotationAssertion( "GO:0003705") -AnnotationAssertion(Annotation( "GOC:vw") "transcription factor") -AnnotationAssertion( "RNA polymerase II transcription factor activity, sequence-specific DNA binding") -AnnotationAssertion( "RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding") -AnnotationAssertion( "sequence-specific DNA binding RNA polymerase II transcription factor activity") -AnnotationAssertion( "RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity") -AnnotationAssertion( "RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity") -AnnotationAssertion( "RNA polymerase II transcription factor activity, copper ion regulated core promoter proximal region sequence-specific binding") -AnnotationAssertion( "RNA polymerase II transcription factor activity, copper ion regulated proximal promoter sequence-specific DNA binding") -AnnotationAssertion( "RNA polymerase II transcription factor activity, metal ion regulated core promoter proximal region sequence-specific binding") -AnnotationAssertion( "RNA polymerase II transcription factor activity, metal ion regulated proximal promoter sequence-specific DNA binding") -AnnotationAssertion( "RNA polymerase II transcription factor activity, metal ion regulated sequence-specific DNA binding") -AnnotationAssertion( "RNA polymerase II transcription factor activity, zinc ion regulated core promoter proximal region sequence-specific DNA binding") -AnnotationAssertion( "RNA polymerase II transcription factor activity, zinc ion regulated proximal promoter sequence-specific DNA binding") -AnnotationAssertion( "copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity") -AnnotationAssertion( "metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity") -AnnotationAssertion( "metal ion regulated sequence-specific DNA binding RNA polymerase II transcription factor activity") -AnnotationAssertion( "sequence-specific distal enhancer binding RNA polymerase II transcription factor activity") -AnnotationAssertion( "transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding") -AnnotationAssertion( "transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding") -AnnotationAssertion( "transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding") -AnnotationAssertion( "zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity") -AnnotationAssertion( "molecular_function") -AnnotationAssertion( "sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity") -AnnotationAssertion( "GO:0000981") -AnnotationAssertion(rdfs:comment "For usage guidance, see comment in GO:0003700 ; DNA-binding transcription factor activity.") -AnnotationAssertion(rdfs:label "DNA-binding transcription factor activity, RNA polymerase II-specific") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) -SubClassOf( ObjectSomeValuesFrom( )) - -# Class: (transcription regulatory region nucleic acid binding) - -AnnotationAssertion(Annotation( "GOC:txnOH") "Binding to a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair.") -AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/20791"^^xsd:anyURI) -AnnotationAssertion( "krc") -AnnotationAssertion( "2010-10-21T04:08:56Z") -AnnotationAssertion( "molecular_function") -AnnotationAssertion( "regulatory region nucleic acid binding") -AnnotationAssertion( "GO:0001067") -AnnotationAssertion(rdfs:label "transcription regulatory region nucleic acid binding") -SubClassOf( ) - # Class: (response to acid chemical) AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "GOC:rn") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form.") @@ -17571,131 +17386,6 @@ AnnotationAssertion(rdfs:comment "Th AnnotationAssertion(rdfs:label "response to acid chemical") SubClassOf( ) -# Class: (DNA-binding transcription activator activity) - -AnnotationAssertion(Annotation( "GOC:txnOH-2018") "A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets.") -AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/16534"^^xsd:anyURI) -AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/16736"^^xsd:anyURI) -AnnotationAssertion( "krc") -AnnotationAssertion( "2011-01-26T03:09:27Z") -AnnotationAssertion( "GO:0001140") -AnnotationAssertion( "GO:0001215") -AnnotationAssertion( "bacterial-type RNA polymerase transcriptional activator activity, metal ion regulated sequence-specific DNA binding") -AnnotationAssertion( "bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding") -AnnotationAssertion( "metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in positive regulation of transcription") -AnnotationAssertion( "sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in positive regulation of transcription") -AnnotationAssertion( "transcriptional activator activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding") -AnnotationAssertion( "molecular_function") -AnnotationAssertion( "bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription") -AnnotationAssertion( "transcriptional activator activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding") -AnnotationAssertion( "GO:0001216") -AnnotationAssertion(rdfs:comment "For usage guidance, see comment in GO:0003700 ; DNA-binding transcription factor activity.") -AnnotationAssertion(rdfs:label "DNA-binding transcription activator activity") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) - -# Class: (DNA-binding transcription repressor activity) - -AnnotationAssertion(Annotation( "GOC:txnOH-2018") "A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets.") -AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/16736"^^xsd:anyURI) -AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/20253"^^xsd:anyURI) -AnnotationAssertion( "krc") -AnnotationAssertion( "2011-01-26T03:15:45Z") -AnnotationAssertion( "GO:0001141") -AnnotationAssertion( "GO:0001218") -AnnotationAssertion( "GO:0001219") -AnnotationAssertion( "GO:0001220") -AnnotationAssertion( "bacterial-type DNA binding transcription repressor activity") -AnnotationAssertion( "bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription") -AnnotationAssertion( "bacterial-type RNA polymerase transcriptional repressor activity, cadmium ion regulated sequence-specific DNA binding") -AnnotationAssertion( "bacterial-type RNA polymerase transcriptional repressor activity, copper ion regulated sequence-specific DNA binding") -AnnotationAssertion( "bacterial-type RNA polymerase transcriptional repressor activity, metal ion regulated sequence-specific DNA binding") -AnnotationAssertion( "bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding") -AnnotationAssertion( "cadmium ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription") -AnnotationAssertion( "copper ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription") -AnnotationAssertion( "metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription") -AnnotationAssertion( "sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription") -AnnotationAssertion( "transcriptional repressor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding") -AnnotationAssertion( "transcriptional repressor activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding") -AnnotationAssertion( "molecular_function") -AnnotationAssertion( "GO:0001217") -AnnotationAssertion(rdfs:comment "For usage guidance, see comment in GO:0003700 ; DNA-binding transcription factor activity.") -AnnotationAssertion(rdfs:label "DNA-binding transcription repressor activity") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) - -# Class: (DNA-binding transcription repressor activity, RNA polymerase II-specific) - -AnnotationAssertion(Annotation( "GOC:txnOH-2018") "A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II.") -AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/16131"^^xsd:anyURI) -AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/16152"^^xsd:anyURI) -AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/16534"^^xsd:anyURI) -AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/20253"^^xsd:anyURI) -AnnotationAssertion( "krc") -AnnotationAssertion( "2010-10-26T03:56:48Z") -AnnotationAssertion( "GO:0001078") -AnnotationAssertion( "GO:0001206") -AnnotationAssertion( "GO:0001210") -AnnotationAssertion( "GO:0001214") -AnnotationAssertion( "RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription") -AnnotationAssertion( "transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding") -AnnotationAssertion( "RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription") -AnnotationAssertion( "RNA polymerase II distal enhancer sequence-specific DNA-binding transcription factor activity involved in negative regulation of transcription") -AnnotationAssertion( "RNA polymerase II transcriptional repressor activity, metal ion regulated core promoter proximal region sequence-specific binding") -AnnotationAssertion( "RNA polymerase II transcriptional repressor activity, metal ion regulated proximal promoter sequence-specific DNA binding") -AnnotationAssertion( "distal enhancer DNA-binding transcription repressor activity, RNA polymerase II-specific") -AnnotationAssertion( "metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in negative regulation of transcription") -AnnotationAssertion( "metal ion regulated sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription") -AnnotationAssertion( "proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific") -AnnotationAssertion( "sequence-specific distal enhancer binding RNA polymerase II transcription factor activity involved in negative regulation of transcription") -AnnotationAssertion( "transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding") -AnnotationAssertion( "transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding") -AnnotationAssertion( "transcriptional repressor activity, metal ion regulated sequence-specific DNA binding") -AnnotationAssertion( "molecular_function") -AnnotationAssertion( "GO:0001227") -AnnotationAssertion(rdfs:comment "For usage guidance, see comment in GO:0003700 ; DNA-binding transcription factor activity.") -AnnotationAssertion(rdfs:label "DNA-binding transcription repressor activity, RNA polymerase II-specific") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) - -# Class: (DNA-binding transcription activator activity, RNA polymerase II-specific) - -AnnotationAssertion(Annotation( "GOC:aruk") Annotation( "GOC:txnOH-2018") Annotation( "PMID:20737563") Annotation( "PMID:27145859") "A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.") -AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/16131"^^xsd:anyURI) -AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/16152"^^xsd:anyURI) -AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/16534"^^xsd:anyURI) -AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/20253"^^xsd:anyURI) -AnnotationAssertion( "krc") -AnnotationAssertion( "2012-01-26T03:10:20Z") -AnnotationAssertion( "GO:0001077") -AnnotationAssertion( "GO:0001205") -AnnotationAssertion( "GO:0001209") -AnnotationAssertion( "GO:0001211") -AnnotationAssertion( "GO:0001212") -AnnotationAssertion( "GO:0001213") -AnnotationAssertion( "RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription") -AnnotationAssertion( "transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding") -AnnotationAssertion( "RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription") -AnnotationAssertion( "RNA polymerase II distal enhancer sequence-specific DNA-binding transcription factor activity involved in positive regulation of transcription") -AnnotationAssertion( "RNA polymerase II transcriptional activator activity, copper ion regulated proximal promoter sequence-specific DNA binding") -AnnotationAssertion( "RNA polymerase II transcriptional activator activity, metal ion regulated core promoter proximal region sequence-specific binding") -AnnotationAssertion( "RNA polymerase II transcriptional activator activity, metal ion regulated proximal promoter sequence-specific DNA binding") -AnnotationAssertion( "RNA polymerase II transcriptional activator activity, zinc ion regulated core promoter proximal region sequence-specific binding") -AnnotationAssertion( "RNA polymerase II transcriptional activator activity, zinc ion regulated proximal promoter sequence-specific DNA binding") -AnnotationAssertion( "copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription") -AnnotationAssertion( "distal enhancer DNA-binding transcription activator activity, RNA polymerase II-specific") -AnnotationAssertion( "metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription") -AnnotationAssertion( "metal ion regulated sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription") -AnnotationAssertion( "proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific") -AnnotationAssertion( "sequence-specific distal enhancer binding RNA polymerase II transcription factor activity involved in positive regulation of transcription") -AnnotationAssertion( "transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding") -AnnotationAssertion( "transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding") -AnnotationAssertion( "transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding") -AnnotationAssertion( "transcriptional activator activity, metal ion regulated sequence-specific DNA binding") -AnnotationAssertion( "zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription") -AnnotationAssertion( "molecular_function") -AnnotationAssertion( "GO:0001228") -AnnotationAssertion(rdfs:comment "For usage guidance, see comment in GO:0003700 ; DNA-binding transcription factor activity.") -AnnotationAssertion(rdfs:label "DNA-binding transcription activator activity, RNA polymerase II-specific") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) - # Class: (skeletal system development) AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GOC:tb") "The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).") @@ -17964,7 +17654,6 @@ SubClassOf( ObjectSomeValuesFrom( (G protein-coupled ADP receptor activity) AnnotationAssertion(Annotation( "GOC:mah") Annotation( "GOC:signaling") Annotation( "PMID:11196645") "Combining with ADP and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.") -AnnotationAssertion( "GO:0045032") AnnotationAssertion( "ADP receptor activity") AnnotationAssertion( "ADP-activated nucleotide receptor activity") AnnotationAssertion( "K101 receptor") @@ -18002,7 +17691,6 @@ SubClassOf( ObjectSomeValuesFrom( (eye development) AnnotationAssertion(Annotation( "GOC:jid") Annotation( "GOC:jl") "The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.") -AnnotationAssertion( "GO:0042460") AnnotationAssertion( "Wikipedia:Eye_development") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0001654") @@ -18115,7 +17803,6 @@ SubClassOf( ObjectSomeValuesFrom( (male germ cell nucleus) AnnotationAssertion(Annotation( "CL:0000015") Annotation( "GOC:hjd") Annotation( "GOC:mtg_sensu") "The nucleus of a male germ cell, a reproductive cell in males.") -AnnotationAssertion( "GO:0043081") AnnotationAssertion( "male germ-cell nucleus") AnnotationAssertion( "cellular_component") AnnotationAssertion( "GO:0001673") @@ -18128,7 +17815,6 @@ SubClassOf( ObjectAllValuesFrom( (female germ cell nucleus) AnnotationAssertion(Annotation( "CL:0000021") Annotation( "GOC:hjd") "The nucleus of the female germ cell, a reproductive cell in females.") -AnnotationAssertion( "GO:0043080") AnnotationAssertion( "female germ-cell nucleus") AnnotationAssertion( "cellular_component") AnnotationAssertion( "GO:0001674") @@ -18187,7 +17873,6 @@ SubClassOf( (histamine biosynthetic process) AnnotationAssertion(Annotation( "GOC:jl") Annotation( "ISBN:0395825172") "The chemical reactions and pathways resulting in the formation of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.") -AnnotationAssertion( "GO:0001693") AnnotationAssertion( "histamine anabolism") AnnotationAssertion( "histamine biosynthesis") AnnotationAssertion( "histamine formation") @@ -18244,8 +17929,6 @@ SubClassOf( ObjectAllValuesFrom( (gastrulation with mouth forming second) AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "GOC:mtg_sensu") "A gastrulation process in which the initial invagination becomes the anus and the mouth forms second.") -AnnotationAssertion( "GO:0010003") -AnnotationAssertion( "GO:0048276") AnnotationAssertion(Annotation( "GOC:dph") "deuterostomic gastrulation") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0001702") @@ -18627,10 +18310,6 @@ SubClassOf( "GOC:add") Annotation( "ISBN:0781735149") "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/19116"^^xsd:anyURI) -AnnotationAssertion( "GO:0042032") -AnnotationAssertion( "GO:0042089") -AnnotationAssertion( "GO:0042107") -AnnotationAssertion( "GO:0050663") AnnotationAssertion( "cytokine biosynthetic process") AnnotationAssertion( "cytokine metabolic process") AnnotationAssertion( "cytokine secretion") @@ -18652,8 +18331,6 @@ SubClassOf( "GOC:add") Annotation( "ISBN:0781735149") "Any process that modulates the frequency, rate, or extent of production of a cytokine.") AnnotationAssertion( ) AnnotationAssertion( ) -AnnotationAssertion( "GO:0042035") -AnnotationAssertion( "GO:0050707") AnnotationAssertion( "regulation of cytokine anabolism") AnnotationAssertion( "regulation of cytokine biosynthesis") AnnotationAssertion( "regulation of cytokine formation") @@ -18674,8 +18351,6 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (negative regulation of cytokine production) AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") "Any process that stops, prevents, or reduces the rate of production of a cytokine.") -AnnotationAssertion( "GO:0042036") -AnnotationAssertion( "GO:0050710") AnnotationAssertion( "down regulation of cytokine biosynthetic process") AnnotationAssertion( "down regulation of cytokine production") AnnotationAssertion( "down-regulation of cytokine biosynthetic process") @@ -18698,8 +18373,6 @@ EquivalentClasses( ObjectIntersection # Class: (positive regulation of cytokine production) AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") "Any process that activates or increases the frequency, rate or extent of production of a cytokine.") -AnnotationAssertion( "GO:0042108") -AnnotationAssertion( "GO:0050715") AnnotationAssertion( "up regulation of cytokine production") AnnotationAssertion( "up-regulation of cytokine production") AnnotationAssertion( "upregulation of cytokine production") @@ -18714,7 +18387,7 @@ EquivalentClasses( ObjectIntersection # Class: (serotonin secretion) -AnnotationAssertion(Annotation( "GOC:ef") Annotation( "ISBN:0198506732") Annotation( "ISBN:0781735149") "The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells.") +AnnotationAssertion(Annotation( "GOC:ef") Annotation( "ISBN:0198506732") Annotation( "ISBN:0781735149") "The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesized in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells.") AnnotationAssertion( "5-HT secretion") AnnotationAssertion( "5-hydroxytryptamine secretion") AnnotationAssertion( "biological_process") @@ -18898,7 +18571,6 @@ SubClassOf( ObjectSomeValuesFrom( (neural tube formation) AnnotationAssertion(Annotation( "GOC:dph") Annotation( "ISBN:0878932437") "The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.") -AnnotationAssertion( "GO:0001679") AnnotationAssertion( "Wikipedia:Neurulation") AnnotationAssertion(Annotation( "GOC:dph") "neural tube morphogenesis") AnnotationAssertion( "neurulation") @@ -19396,7 +19068,6 @@ SubClassOf( ObjectSomeValuesFrom( (hair follicle development) AnnotationAssertion(Annotation( "GOC:dph") Annotation( "UBERON:0002073") "The process whose specific outcome is the progression of the hair follicle over time, from its formation to the mature structure. A hair follicle is a tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open.") -AnnotationAssertion( "GO:0001943") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0001942") AnnotationAssertion(rdfs:label "hair follicle development") @@ -19688,7 +19359,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:TermGenie") "Any process that modulates the frequency, rate or extent of L-glutamate import into a cell.") AnnotationAssertion( "al") AnnotationAssertion( "2012-06-13T07:34:08Z") -AnnotationAssertion( "GO:1900920") AnnotationAssertion( "regulation of L-glutamate import") AnnotationAssertion( "regulation of L-glutamate transport") AnnotationAssertion(Annotation( "GOC:TermGenie") "regulation of L-glutamate uptake") @@ -19702,7 +19372,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:TermGenie") "Any process that stops, prevents or reduces the frequency, rate or extent of L-glutamate import into a cell.") AnnotationAssertion( "al") AnnotationAssertion( "2012-06-13T07:34:30Z") -AnnotationAssertion( "GO:1900921") AnnotationAssertion( "down regulation of L-glutamate transport") AnnotationAssertion( "down-regulation of L-glutamate transport") AnnotationAssertion( "downregulation of L-glutamate transport") @@ -19729,7 +19398,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:TermGenie") "Any process that activates or increases the frequency, rate or extent of L-glutamate import into a cell.") AnnotationAssertion( "al") AnnotationAssertion( "2012-06-13T07:34:38Z") -AnnotationAssertion( "GO:1900922") AnnotationAssertion( "positive regulation of L-glutamate import") AnnotationAssertion( "positive regulation of L-glutamate transport") AnnotationAssertion( "up regulation of L-glutamate transport") @@ -20099,7 +19767,6 @@ SubClassOf( ObjectSomeValuesFrom( (defense response to insect) AnnotationAssertion(Annotation( "GOC:add") "A response to protect an organism from a directly detected or perceived external threat from an insect or insects to that organism.") -AnnotationAssertion( "GO:0002214") AnnotationAssertion( "physiological defense response to insect") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0002213") @@ -20109,7 +19776,6 @@ EquivalentClasses( ObjectIntersection # Class: (defense response to nematode) AnnotationAssertion(Annotation( "GOC:add") Annotation( "PMID:11516579") Annotation( "PMID:14506883") "A response to protect an organism from a directly detected or perceived external threat from a nematode or nematodes, which results in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.") -AnnotationAssertion( "GO:0002216") AnnotationAssertion( "physiological defense response to nematode") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0002215") @@ -21161,8 +20827,6 @@ SubClassOf( (cytokine production involved in immune response) AnnotationAssertion(Annotation( "GOC:add") Annotation( "GO_REF:0000022") Annotation( "ISBN:0781735149") "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels.") -AnnotationAssertion( "GO:0002374") -AnnotationAssertion( "GO:0002375") AnnotationAssertion( "cytokine biosynthetic process involved in immune response") AnnotationAssertion( "biological_process") AnnotationAssertion(Annotation( "GOC:dph") "cytokine production during immune response") @@ -21276,8 +20940,6 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (immunoglobulin production) AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.") -AnnotationAssertion( "GO:0002378") -AnnotationAssertion( "GO:0048305") AnnotationAssertion( "antibody production") AnnotationAssertion( "immunoglobulin biosynthetic process") AnnotationAssertion( "immunoglobulin secretion") @@ -21291,8 +20953,6 @@ SubClassOf( (immunoglobulin production involved in immunoglobulin-mediated immune response) AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") Annotation( "PMID:9185563") "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels.") -AnnotationAssertion( "GO:0002379") -AnnotationAssertion( "GO:0002380") AnnotationAssertion( "immunoglobulin production involved in immunoglobulin mediated immune response") AnnotationAssertion( "immunoglobulin biosynthetic process involved in immune response") AnnotationAssertion( "immunoglobulin secretion involved in immune response") @@ -21321,8 +20981,6 @@ SubClassOf( ObjectAllValuesFrom( (mucosal immune response) AnnotationAssertion(Annotation( "GOC:jal") Annotation( "GO_REF:0000022") Annotation( "ISBN:0781735149") "An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract.") -AnnotationAssertion( "GO:0002386") -AnnotationAssertion( "GO:0002422") AnnotationAssertion( "immune response in MALT") AnnotationAssertion( "immune response in mucosal-associated lymphoid tissue") AnnotationAssertion( "immune response in urogenital tract") @@ -21538,8 +21196,6 @@ SubClassOf( ObjectSomeValuesFrom( (leukocyte mediated immunity) AnnotationAssertion(Annotation( "GOC:add") Annotation( "GO_REF:0000022") Annotation( "ISBN:0781735149") "Any process involved in the carrying out of an immune response by a leukocyte.") -AnnotationAssertion( "GO:0019723") -AnnotationAssertion( "GO:0042087") AnnotationAssertion( "immune cell effector process") AnnotationAssertion( "immune cell mediated immunity") AnnotationAssertion( "leucocyte immune effector process") @@ -22645,6 +22301,7 @@ EquivalentClasses( ObjectIntersection # Class: (negative regulation of proteolysis associated with antigen processing and presentation) AnnotationAssertion(Annotation( "GOC:add") "Any process that stops, prevents, or reduces the frequency, rate, or extent of proteolysis associated with antigen processing and presentation.") +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/29024"^^xsd:anyURI) AnnotationAssertion( "down regulation of proteolysis associated with antigen processing and presentation") AnnotationAssertion( "down-regulation of proteolysis associated with antigen processing and presentation") AnnotationAssertion( "downregulation of proteolysis associated with antigen processing and presentation") @@ -22653,7 +22310,7 @@ AnnotationAssertion( "GO:0002629") AnnotationAssertion(rdfs:label "negative regulation of proteolysis associated with antigen processing and presentation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) +SubClassOf( ) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -22669,7 +22326,7 @@ AnnotationAssertion( "GO:0002630") AnnotationAssertion(rdfs:label "positive regulation of proteolysis associated with antigen processing and presentation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) +SubClassOf( ) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) @@ -22746,8 +22403,6 @@ EquivalentClasses( ObjectIntersection # Class: (regulation of immunoglobulin production) AnnotationAssertion(Annotation( "GOC:add") "Any process that modulates the frequency, rate, or extent of immunoglobulin production.") -AnnotationAssertion( "GO:0002640") -AnnotationAssertion( "GO:0051023") AnnotationAssertion( "regulation of antibody production") AnnotationAssertion( "regulation of immunoglobulin biosynthetic process") AnnotationAssertion( "regulation of immunoglobulin secretion") @@ -22760,8 +22415,6 @@ SubClassOf( (negative regulation of immunoglobulin production) AnnotationAssertion(Annotation( "GOC:add") "Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin production.") -AnnotationAssertion( "GO:0002641") -AnnotationAssertion( "GO:0051025") AnnotationAssertion( "down regulation of immunoglobulin production") AnnotationAssertion( "down-regulation of immunoglobulin production") AnnotationAssertion( "downregulation of immunoglobulin production") @@ -22778,8 +22431,6 @@ SubClassOf( (positive regulation of immunoglobulin production) AnnotationAssertion(Annotation( "GOC:add") "Any process that activates or increases the frequency, rate, or extent of immunoglobulin production.") -AnnotationAssertion( "GO:0002642") -AnnotationAssertion( "GO:0051024") AnnotationAssertion( "up regulation of immunoglobulin production") AnnotationAssertion( "up-regulation of immunoglobulin production") AnnotationAssertion( "upregulation of immunoglobulin production") @@ -23572,7 +23223,6 @@ EquivalentClasses( ObjectIntersection # Class: (regulation of natural killer cell mediated immunity) AnnotationAssertion(Annotation( "GOC:add") "Any process that modulates the frequency, rate, or extent of natural killer cell mediated immunity.") -AnnotationAssertion( "GO:0045845") AnnotationAssertion( "regulation of NK cell mediated immunity") AnnotationAssertion( "biological_process") AnnotationAssertion( "regulation of natural killer cell activity") @@ -23583,7 +23233,6 @@ EquivalentClasses( ObjectIntersection # Class: (negative regulation of natural killer cell mediated immunity) AnnotationAssertion(Annotation( "GOC:add") "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immunity.") -AnnotationAssertion( "GO:0030102") AnnotationAssertion( "down regulation of natural killer cell mediated immunity") AnnotationAssertion( "down-regulation of natural killer cell mediated immunity") AnnotationAssertion( "downregulation of natural killer cell mediated immunity") @@ -23599,7 +23248,6 @@ EquivalentClasses( ObjectIntersection # Class: (positive regulation of natural killer cell mediated immunity) AnnotationAssertion(Annotation( "GOC:add") "Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immunity.") -AnnotationAssertion( "GO:0045846") AnnotationAssertion( "positive regulation of NK cell mediated immunity") AnnotationAssertion( "up regulation of natural killer cell mediated immunity") AnnotationAssertion( "up-regulation of natural killer cell mediated immunity") @@ -23616,8 +23264,6 @@ EquivalentClasses( ObjectIntersection # Class: (regulation of cytokine production involved in immune response) AnnotationAssertion(Annotation( "GOC:add") "Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response.") -AnnotationAssertion( "GO:0002739") -AnnotationAssertion( "GO:0002742") AnnotationAssertion( "regulation of cytokine biosynthetic process involved in immune response") AnnotationAssertion( "regulation of cytokine secretion involved in immune response") AnnotationAssertion( "biological_process") @@ -23629,8 +23275,6 @@ EquivalentClasses( ObjectIntersection # Class: (negative regulation of cytokine production involved in immune response) AnnotationAssertion(Annotation( "GOC:add") "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response.") -AnnotationAssertion( "GO:0002740") -AnnotationAssertion( "GO:0002743") AnnotationAssertion( "down-regulation of cytokine production during immune response") AnnotationAssertion( "negative regulation of cytokine biosynthetic process involved in immune response") AnnotationAssertion( "negative regulation of cytokine secretion involved in immune response") @@ -23646,8 +23290,6 @@ EquivalentClasses( ObjectIntersection # Class: (positive regulation of cytokine production involved in immune response) AnnotationAssertion(Annotation( "GOC:add") "Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response.") -AnnotationAssertion( "GO:0002741") -AnnotationAssertion( "GO:0002744") AnnotationAssertion( "activation of cytokine production during immune response") AnnotationAssertion( "positive regulation of cytokine biosynthetic process involved in immune response") AnnotationAssertion( "positive regulation of cytokine secretion involved in immune response") @@ -24729,7 +24371,6 @@ SubClassOf( (respiratory system process) AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_cardio") Annotation( "GOC:tb") "A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange.") -AnnotationAssertion( "GO:0010802") AnnotationAssertion( "respiratory gaseous exchange") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0003016") @@ -25952,6 +25593,7 @@ SubClassOf( ObjectSomeValuesFrom( (heart rudiment morphogenesis) AnnotationAssertion(Annotation( "GOC:mtg_heart") "The process in which the anatomical structures of the heart rudiment are generated and organized.") +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/22938"^^xsd:anyURI) AnnotationAssertion( "dph") AnnotationAssertion( "2009-10-27T08:38:04Z") AnnotationAssertion(Annotation( "GOC:mtg_heart") "heart cone morphogenesis") @@ -25961,6 +25603,7 @@ AnnotationAssertion(rdfs:label "hear EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) # Class: (heart rudiment formation) @@ -26155,7 +25798,6 @@ AnnotationAssertion( ) AnnotationAssertion( "dph") AnnotationAssertion( "2009-11-24T09:56:26Z") -AnnotationAssertion( "GO:0036142") AnnotationAssertion( "microtubule-based flagellum movement") AnnotationAssertion(Annotation( "GOC:bf") "flagellar movement") AnnotationAssertion( "flagellum movement") @@ -26240,7 +25882,6 @@ SubClassOf( "GOC:dph") "Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.") AnnotationAssertion( "dph") AnnotationAssertion( "2009-12-03T10:12:00Z") -AnnotationAssertion( "GO:1900172") AnnotationAssertion( "regulation of microtubule-based flagellum movement") AnnotationAssertion( "biological_process") AnnotationAssertion(Annotation( "GOC:TermGenie") "regulation of flagellar movement") @@ -26255,7 +25896,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:dph") "Any process that increases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.") AnnotationAssertion( "dph") AnnotationAssertion( "2009-12-03T10:16:10Z") -AnnotationAssertion( "GO:1900174") AnnotationAssertion( "positive regulation of microtubule-based flagellum movement") AnnotationAssertion( "biological_process") AnnotationAssertion(Annotation( "GOC:TermGenie") "positive regulation of flagellar movement") @@ -26270,7 +25910,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:dph") "Any process that decreases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.") AnnotationAssertion( "dph") AnnotationAssertion( "2009-12-03T10:17:47Z") -AnnotationAssertion( "GO:1900173") AnnotationAssertion( "negative regulation of microtubule-based flagellum movement") AnnotationAssertion( "biological_process") AnnotationAssertion( "negative regulation of flagellum movement") @@ -26620,7 +26259,6 @@ EquivalentClasses( ObjectIntersection # Class: (molecular_function) AnnotationAssertion(Annotation( "GOC:pdt") "A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs.") -AnnotationAssertion( "GO:0005554") AnnotationAssertion( "molecular function") AnnotationAssertion( "molecular_function") AnnotationAssertion( "GO:0003674") @@ -26639,7 +26277,6 @@ DisjointClasses( (nucleic acid binding) AnnotationAssertion(Annotation( "GOC:jl") "Binding to a nucleic acid.") -AnnotationAssertion( "GO:0000496") AnnotationAssertion( "base pairing") AnnotationAssertion( "molecular_function") AnnotationAssertion( "GO:0003676") @@ -26653,7 +26290,6 @@ EquivalentClasses( ObjectIntersection # Class: (DNA binding) AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:jl") Annotation( "GOC:tb") Annotation( "GOC:vw") "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).") -AnnotationAssertion( "GO:0043566") AnnotationAssertion( "plasmid binding") AnnotationAssertion( "molecular_function") AnnotationAssertion( "microtubule/chromatin interaction") @@ -26692,80 +26328,9 @@ AnnotationAssertion( "chromatin binding") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -# Class: (double-stranded DNA binding) - -AnnotationAssertion(Annotation( "GOC:elh") Annotation( "GOC:vw") "Binding to double-stranded DNA.") -AnnotationAssertion(Annotation( "GOC:elh") "dsDNA binding") -AnnotationAssertion( "molecular_function") -AnnotationAssertion( "GO:0003690") -AnnotationAssertion(rdfs:label "double-stranded DNA binding") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) - -# Class: (DNA-binding transcription factor activity) - -AnnotationAssertion(Annotation( "GOC:txnOH-2018") "A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.") -AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/15704"^^xsd:anyURI) -AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/16534"^^xsd:anyURI) -AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/20253"^^xsd:anyURI) -AnnotationAssertion( "krc") -AnnotationAssertion( "2010-10-21T04:37:54Z") -AnnotationAssertion( "GO:0000130") -AnnotationAssertion( "GO:0001071") -AnnotationAssertion( "GO:0001130") -AnnotationAssertion( "GO:0001131") -AnnotationAssertion( "GO:0001151") -AnnotationAssertion( "GO:0001199") -AnnotationAssertion( "GO:0001204") -AnnotationAssertion( "nucleic acid binding transcription factor activity") -AnnotationAssertion( "transcription factor activity") -AnnotationAssertion( "DNA binding transcription factor activity") -AnnotationAssertion( "gene-specific transcription factor activity") -AnnotationAssertion( "sequence-specific DNA binding transcription factor activity") -AnnotationAssertion( "bacterial-type DNA binding transcription factor activity") -AnnotationAssertion( "bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity") -AnnotationAssertion( "bacterial-type RNA polymerase transcription enhancer sequence-specific DNA binding transcription factor activity") -AnnotationAssertion( "bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding") -AnnotationAssertion( "bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding") -AnnotationAssertion( "metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity") -AnnotationAssertion( "metal ion regulated sequence-specific DNA binding transcription factor activity") -AnnotationAssertion( "sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity") -AnnotationAssertion( "transcription factor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding") -AnnotationAssertion( "transcription factor activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding") -AnnotationAssertion( "transcription factor activity, bacterial-type RNA polymerase transcription enhancer sequence-specific binding") -AnnotationAssertion( "transcription factor activity, metal ion regulated sequence-specific DNA binding") -AnnotationAssertion( "molecular_function") -AnnotationAssertion( "GO:0003700") -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion(rdfs:comment "Usage guidance: Most DNA-binding transcription factors do not have enzymatic activity. The presence of specific DNA-binding domains known to be present in DNA-binding transcription factors (HOX, GATA etc) should be used to help decide whether a protein is a DNA binding transcription factor or a coregulator. If a protein has an enzymatic activity (for example, ubiquitin ligase, histone acetyl transferase) and no known DNA binding domain, consider annotating to GO:0003712 transcription coregulator activity. Special care should be taken with proteins containing zinc fingers, Myb/SANT and ARID domains, since only a subset of proteins containing these domains directly and selectively bind to regulatory DNA motifs in cis-regulatory regions.") -AnnotationAssertion(rdfs:label "DNA-binding transcription factor activity") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) - -# Class: (nuclear steroid receptor activity) - -AnnotationAssertion(Annotation( "GOC:signaling") Annotation( "PMID:14708019") "Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function.") -AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/16717"^^xsd:anyURI) -AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/26957"^^xsd:anyURI) -AnnotationAssertion( "steroid hormone receptor activity") -AnnotationAssertion( "molecular_function") -AnnotationAssertion( "GO:0003707") -AnnotationAssertion(rdfs:label "nuclear steroid receptor activity") -SubClassOf( ) -SubClassOf( ) -SubClassOf( ObjectSomeValuesFrom( )) - # Class: (RNA binding) AnnotationAssertion(Annotation( "GOC:jl") Annotation( "GOC:mah") "Binding to an RNA molecule or a portion thereof.") -AnnotationAssertion( "GO:0000498") -AnnotationAssertion( "GO:0044822") AnnotationAssertion(Annotation(rdfs:label "Exportin-5 recognizes 3' overhang of pre-miRNA") "Reactome:R-HSA-203922") AnnotationAssertion( "base pairing with RNA") AnnotationAssertion( "molecular_function") @@ -26816,7 +26381,6 @@ AnnotationAssertion(Annotation( "https://github.com/geneontology/go-ontology/issues/18664"^^xsd:anyURI) AnnotationAssertion( "vw") AnnotationAssertion( "2016-04-04T10:59:42Z") -AnnotationAssertion( "GO:1990939") AnnotationAssertion( "dynein") AnnotationAssertion( "kinesin") AnnotationAssertion(Annotation(rdfs:label "Axonal transport of NGF:Trk complexes") "Reactome:R-HSA-177479") @@ -26870,7 +26434,6 @@ SubClassOf( (DNA nuclease activity) AnnotationAssertion(Annotation( "GOC:mah") Annotation( "ISBN:0198547684") "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid.") -AnnotationAssertion( "GO:0004537") AnnotationAssertion(Annotation(rdfs:label "Cleavage of DNA by DFF40") "Reactome:R-HSA-211247") AnnotationAssertion(Annotation(rdfs:label "Long-range resection of DNA DSBs by EXO1 or DNA2") "Reactome:R-HSA-5685994") AnnotationAssertion(Annotation(rdfs:label "DNA nucleases unhook the interstrand crosslink (ICL)") "Reactome:R-HSA-6785986") @@ -26886,7 +26449,6 @@ SubClassOf( ObjectSomeValuesFrom( (protein kinase activity) AnnotationAssertion(Annotation( "PMID:25399640") "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.") -AnnotationAssertion( "GO:0050222") AnnotationAssertion(Annotation(rdfs:label "INF-gamma induced phosphorylation of L13a") "Reactome:R-HSA-156832") AnnotationAssertion(Annotation(rdfs:label "IRAK1 phosphorylates Pellino") "Reactome:R-HSA-937034") AnnotationAssertion(Annotation(rdfs:label "Unknown kinase phosphorylates NICD4") "Reactome:R-HSA-9604606") @@ -26919,7 +26481,6 @@ SubClassOf( (protein tyrosine kinase activity) AnnotationAssertion(Annotation( "RHEA:10596") "Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.") -AnnotationAssertion( "GO:0004718") AnnotationAssertion(Annotation( "skos:exactMatch") "EC:2.7.10.-") AnnotationAssertion( "MetaCyc:2.7.10.1-RXN") AnnotationAssertion(Annotation( "skos:exactMatch") "RHEA:10596") @@ -27299,6 +26860,15 @@ AnnotationAssertion(Annotation(rdfs:label "SH pentamer is phosphorylated") "Reactome:R-HSA-983703") AnnotationAssertion(Annotation(rdfs:label "SYK autophosphorylates at the activated BCR") "Reactome:R-HSA-983707") AnnotationAssertion(Annotation(rdfs:label "LYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B)") "Reactome:R-HSA-983709") +AnnotationAssertion(Annotation(rdfs:label "ABL1 phosphorylates PPARG2") "Reactome:R-HSA-9841924") +AnnotationAssertion(Annotation(rdfs:label "Autophosphorylation of LTK dimer:ALKAL1,2") "Reactome:R-HSA-9842648") +AnnotationAssertion(Annotation(rdfs:label "Active LTK receptor phosphorylates SHC1") "Reactome:R-HSA-9842651") +AnnotationAssertion(Annotation(rdfs:label "Active LTK phosphorylates IRS1") "Reactome:R-HSA-9842666") +AnnotationAssertion(Annotation(rdfs:label "CLIP1-LTK fusion autophosphorylates") "Reactome:R-HSA-9842667") +AnnotationAssertion(Annotation(rdfs:label "Phosphorylation of KDR (VEGFR2) and FLT4 (VEGFR3) and PECAM1 in PECAM1:CDH5:KDR:FLT4:CTNNB1") "Reactome:R-HSA-9860500") +AnnotationAssertion(Annotation(rdfs:label "p-T816-PKN2 phosphorylates AKT1 on serine-308") "Reactome:R-HSA-9860759") +AnnotationAssertion(Annotation(rdfs:label "p-Y397-PTK2 (FAK) phosphorylates CHUK (IKKA)") "Reactome:R-HSA-9861469") +AnnotationAssertion(Annotation(rdfs:label "p-Y393-ABL1 phosphorylates tyrosine-407 of YAP1") "Reactome:R-HSA-9865196") AnnotationAssertion( "protein-tyrosine kinase activity") AnnotationAssertion( "molecular_function") AnnotationAssertion( "GO:0004713") @@ -27366,70 +26936,9 @@ AnnotationAssertion(rdfs:label "tran SubClassOf( ) SubClassOf( ) -# Class: (nuclear receptor activity) - -AnnotationAssertion(Annotation( "GOC:txnOH-2018") Annotation( "PMID:23457262") "A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus.") -AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/19518"^^xsd:anyURI) -AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/20253"^^xsd:anyURI) -AnnotationAssertion( "GO:0003708") -AnnotationAssertion( "GO:0004880") -AnnotationAssertion( "GO:0004882") -AnnotationAssertion( "GO:0004884") -AnnotationAssertion( "GO:0004886") -AnnotationAssertion( "GO:0004887") -AnnotationAssertion( "GO:0008434") -AnnotationAssertion( "GO:0038050") -AnnotationAssertion( "GO:0038051") -AnnotationAssertion( "GO:0038052") -AnnotationAssertion( "RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding") -AnnotationAssertion( "ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity") -AnnotationAssertion(Annotation( "Wikipedia:Calcitriol") "1,25-(OH)2D3 receptor activity") -AnnotationAssertion( "9-cis retinoic acid receptor activity") -AnnotationAssertion( "RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding") -AnnotationAssertion( "RNA polymerase II transcription factor activity, glucocorticoid-activated sequence-specific DNA binding") -AnnotationAssertion( "RXR") -AnnotationAssertion( "androgen receptor activity") -AnnotationAssertion( "calcitriol receptor activity") -AnnotationAssertion( "ecdysteroid hormone receptor activity") -AnnotationAssertion(Annotation( "GOC:bf") "estrogen nuclear receptor activity") -AnnotationAssertion(Annotation( "GOC:bf") "glucocorticoid receptor activity") -AnnotationAssertion( "juvenile hormone receptor activity") -AnnotationAssertion( "nuclear hormone receptor") -AnnotationAssertion( "retinoic acid receptor activity") -AnnotationAssertion(Annotation( "GOC:bf") "retinoid-X receptor activity") -AnnotationAssertion( "thyroid hormone receptor activity") -AnnotationAssertion( "vitamin A receptor activity") -AnnotationAssertion( "vitamin D receptor activity") -AnnotationAssertion(Annotation( "GOC:bf") Annotation( "Wikipedia:Calcitriol_receptor") "vitamin D3 receptor activity") -AnnotationAssertion( "molecular_function") -AnnotationAssertion(Annotation( "GOC:bf") "ligand-dependent nuclear receptor activity") -AnnotationAssertion(Annotation( "GOC:bf") "ligand-dependent transcription factor activity") -AnnotationAssertion( "GO:0004879") -AnnotationAssertion(rdfs:comment "Usage guidance: Nuclear receptors are a protein family defined by the presence of a C4-type zinc finger DNA-binding domain and a ligand binding domain. For nuclear receptors, the DNA binding motif is most often referred to as a response element. GO:0004879 is intended for annotation of nuclear receptors that regulate transcription by binding directly to DNA. When the nuclear receptor functions by binding to other transcription factors or transcription factor complexes, consider instead annotating to 'GO:0030374 ; nuclear receptor transcription coactivator activity' or GO:0140536 ; nuclear corepressor activity.") -AnnotationAssertion(rdfs:label "nuclear receptor activity") -SubClassOf( ) -SubClassOf( ) -SubClassOf( ) -SubClassOf( ObjectSomeValuesFrom( )) - -# Class: (nuclear glucocorticoid receptor activity) - -AnnotationAssertion(Annotation( "GOC:signaling") Annotation( "PMID:17689856") Annotation( "PMID:20920967") "Combining with a glucocorticoid and transmitting the signal within the cell trigger a change in cell activity or function.") -AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/16717"^^xsd:anyURI) -AnnotationAssertion( "glucocorticoid receptor activity") -AnnotationAssertion( "molecular_function") -AnnotationAssertion( "GO:0004883") -AnnotationAssertion(rdfs:label "nuclear glucocorticoid receptor activity") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) -SubClassOf( ObjectSomeValuesFrom( )) -SubClassOf( ObjectSomeValuesFrom( )) - # Class: (transmembrane signaling receptor activity) AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "Wikipedia:Transmembrane_receptor") "Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.") -AnnotationAssertion( "GO:0004926") -AnnotationAssertion( "GO:0099600") AnnotationAssertion(Annotation( "GOC:bf") Annotation( "GOC:signaling") "transmembrane receptor activity") AnnotationAssertion(Annotation(rdfs:label "Sphingomyelinase is activated by the NGF:p75NTR complex") "Reactome:R-HSA-193672") AnnotationAssertion(Annotation( "GOC:mah") "transmembrane signalling receptor activity") @@ -27442,7 +26951,6 @@ SubClassOf( (cytokine receptor activity) AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:mah") "Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.") -AnnotationAssertion( "GO:0004907") AnnotationAssertion( "IL receptor") AnnotationAssertion(Annotation( "http://wiki.geneontology.org/index.php/Why_isn%27t_interleukin_in_GO%3F") "interleukin receptor activity") AnnotationAssertion( "molecular_function") @@ -27471,14 +26979,10 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (G protein-coupled receptor activity) AnnotationAssertion(Annotation( "GOC:bf") Annotation( "Wikipedia:GPCR") "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.") -AnnotationAssertion( "GO:0001622") -AnnotationAssertion( "GO:0001623") -AnnotationAssertion( "GO:0001624") -AnnotationAssertion( "GO:0001625") -AnnotationAssertion( "GO:0016526") AnnotationAssertion(Annotation(rdfs:label "Thrombin-activated PARs activate G12/13") "Reactome:R-HSA-114552") AnnotationAssertion(Annotation(rdfs:label "Thrombin-activated PARs activate Gq") "Reactome:R-HSA-114558") AnnotationAssertion(Annotation(rdfs:label "The high affinity receptor complex binds to G-protein") "Reactome:R-HSA-167408") +AnnotationAssertion(Annotation(rdfs:label "GLP1R:GLP1 activates G(s)") "Reactome:R-HSA-381706") AnnotationAssertion( "Wikipedia:GPCR") AnnotationAssertion( "G protein coupled receptor activity") AnnotationAssertion( "G protein linked receptor activity") @@ -27593,8 +27097,6 @@ SubClassOf( "GOC:ai") "Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/12942"^^xsd:anyURI) -AnnotationAssertion( "GO:0001585") -AnnotationAssertion( "GO:0016609") AnnotationAssertion( "Wikipedia:5-HT_receptor") AnnotationAssertion( "5-HT receptor") AnnotationAssertion( "5-hydroxytryptamine receptor") @@ -27625,7 +27127,6 @@ SubClassOf( ObjectSomeValuesFrom( (vasopressin receptor activity) AnnotationAssertion(Annotation( "GOC:ai") "Combining with vasopressin to initiate a change in cell activity.") -AnnotationAssertion( "GO:0016931") AnnotationAssertion( "vasopressin activated calcium mobilizing receptor activity") AnnotationAssertion( "molecular_function") AnnotationAssertion( "GO:0005000") @@ -27735,7 +27236,6 @@ SubClassOf( "GOC:ai") Annotation( "GOC:dgf") "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, accross or in between cells.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/27621"^^xsd:anyURI) -AnnotationAssertion( "GO:0005478") AnnotationAssertion( "molecular_function") AnnotationAssertion( "carrier") AnnotationAssertion( "GO:0005215") @@ -27770,8 +27270,9 @@ SubClassOf( (calcium-activated cation channel activity) -AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_transport") "Enables the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient.") +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_transport") "Enables the transmembrane transfer of an inorganic cation by a channel that opens when a calcium cation has been bound by the channel complex or one of its constituent parts.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/24605"^^xsd:anyURI) +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/28979"^^xsd:anyURI) AnnotationAssertion(Annotation(rdfs:label "TRPM4 transports Na+ from the extracellular region to the cytosol") "Reactome:R-HSA-9717383") AnnotationAssertion( "calcium activated cation channel activity") AnnotationAssertion( "intracellular calcium-activated potassium channel") @@ -27807,8 +27308,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:def") Annotation( "GOC:dph") Annotation( "GOC:mtg_transport") Annotation( "GOC:pr") Annotation( "ISBN:0815340729") "Enables the energy-independent facilitated diffusion of a monoatomic cation through a transmembrane aqueous pore or channel.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/24479"^^xsd:anyURI) -AnnotationAssertion( "GO:0015281") -AnnotationAssertion( "GO:0015338") AnnotationAssertion( "cation channel activity") AnnotationAssertion(Annotation(rdfs:label "STIM1 oligomerizes") "Reactome:R-HSA-1168376") AnnotationAssertion(Annotation(rdfs:label "Activation of HCN channels") "Reactome:R-HSA-1296043") @@ -27830,6 +27329,8 @@ EquivalentClasses( ObjectIntersection # Class: (calcium channel activity) AnnotationAssertion(Annotation( "GOC:mtg_transport") Annotation( "GOC:pr") Annotation( "ISBN:0815340729") "Enables the energy-independent facilitated diffusion of a calcium ion through a transmembrane aqueous pore or channel.") +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/27521"^^xsd:anyURI) +AnnotationAssertion(Annotation( "skos:broadMatch") "RHEA:29671") AnnotationAssertion(Annotation(rdfs:label "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol") "Reactome:R-HSA-139854") AnnotationAssertion(Annotation(rdfs:label "P2X1-mediated entry of Ca++ from plasma") "Reactome:R-HSA-139855") AnnotationAssertion(Annotation(rdfs:label "Ca2+ influx through voltage gated Ca2+ channels") "Reactome:R-HSA-210420") @@ -27837,15 +27338,19 @@ AnnotationAssertion(Annotation(rdfs:label "TRPs transport extracellular Ca2+ to AnnotationAssertion(Annotation(rdfs:label "VDAC1,2,3 translocate calcium from the cytosol to the mitochondrial intermembrane space") "Reactome:R-HSA-8949145") AnnotationAssertion(Annotation(rdfs:label "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix") "Reactome:R-HSA-8949178") AnnotationAssertion(Annotation(rdfs:label "CHRNA9:CHRNA10:AcCho transports Ca2+ from the extracellular region to the cytosol") "Reactome:R-HSA-9663785") +AnnotationAssertion(Annotation(rdfs:label "TRPV4 tetramer:CALM1:Ca2+ transports calcium ions (Ca2+) from the extracellular region to the cytosol") "Reactome:R-HSA-9858800") AnnotationAssertion( "molecular_function") AnnotationAssertion( "GO:0005262") AnnotationAssertion(rdfs:label "calcium channel activity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) # Class: (potassium channel activity) AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mtg_transport") Annotation( "GOC:pr") Annotation( "ISBN:0815340729") "Enables the energy-independent facilitated diffusion of a potassium ion through a transmembrane aqueous pore or channel.") +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/27521"^^xsd:anyURI) +AnnotationAssertion(Annotation( "skos:broadMatch") "RHEA:29463") AnnotationAssertion(Annotation(rdfs:label "Activation of ATP sensitive Potassium channels in neuroendocrine cells") "Reactome:R-HSA-1296024") AnnotationAssertion(Annotation(rdfs:label "Activation of Ca2+ activated Potassium channels with Intermediate conductance") "Reactome:R-HSA-1296035") AnnotationAssertion(Annotation(rdfs:label "Activation of Ca2+ activated Potassium channels with large conductance") "Reactome:R-HSA-1296037") @@ -27865,10 +27370,13 @@ EquivalentClasses( ObjectIntersection SubClassOf( ) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) # Class: (sodium channel activity) AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mtg_transport") Annotation( "GOC:pr") Annotation( "ISBN:0815340729") "Enables the energy-independent facilitated diffusion of a sodium ion through a transmembrane aqueous pore or channel.") +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/27521"^^xsd:anyURI) +AnnotationAssertion(Annotation( "skos:broadMatch") "RHEA:34963") AnnotationAssertion(Annotation(rdfs:label "UNC79:UNC80:NALCN transports Na+ extracellular region to cytosol") "Reactome:R-HSA-2730664") AnnotationAssertion(Annotation(rdfs:label "TRPM4,5 transport extracellular Na+ to cytosol") "Reactome:R-HSA-3295580") AnnotationAssertion(Annotation(rdfs:label "SCN3A:SCN2B,4B transports Na+ from the extracellular region to the cytosol") "Reactome:R-HSA-9717374") @@ -27880,11 +27388,11 @@ AnnotationAssertion( "sodium channel activity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) # Class: (amine transmembrane transporter activity) AnnotationAssertion(Annotation( "GOC:mtg_transport") Annotation( "ISBN:0198506732") Annotation( "ISBN:0815340729") "Enables the transfer of amines, including polyamines, from one side of a membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group.") -AnnotationAssertion( "GO:0005279") AnnotationAssertion( "amine/amide/polyamine channel activity") AnnotationAssertion( "amine/polyamine transmembrane transporter activity") AnnotationAssertion( "amino acid-polyamine transmembrane transporter activity") @@ -27919,9 +27427,9 @@ SubClassOf( ObjectSomeValuesFrom( (L-glutamate transmembrane transporter activity) AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:mtg_transport") Annotation( "ISBN:0815340729") "Enables the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid.") +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/27521"^^xsd:anyURI) AnnotationAssertion( "L-glutamate transporter activity") AnnotationAssertion( "glutamate transmembrane transporter activity") -AnnotationAssertion(Annotation( "skos:broadMatch") "RHEA:66336") AnnotationAssertion(Annotation(rdfs:label "L-Glutamate loading of synaptic vesicle") "Reactome:R-HSA-210444") AnnotationAssertion(Annotation(rdfs:label "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+") "Reactome:R-HSA-428052") AnnotationAssertion(Annotation(rdfs:label "Defective SLC17A8 does not exchange cytosolic L-Glu for synaptic vesicle H+") "Reactome:R-HSA-5624256") @@ -27933,22 +27441,18 @@ AnnotationAssertion(rdfs:label "L-gl EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) -SubClassOf( ObjectSomeValuesFrom( )) # Class: (phosphate transmembrane transporter activity) AnnotationAssertion(Annotation( "GOC:mtg_transport") "Enables the transfer of phosphate ions from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/27121"^^xsd:anyURI) -AnnotationAssertion( "GO:0005317") -AnnotationAssertion( "GO:1901677") -AnnotationAssertion( "RHEA:32823") +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/27521"^^xsd:anyURI) AnnotationAssertion( "inorganic phosphate transmembrane transporter activity") AnnotationAssertion( "molecular_function") AnnotationAssertion( "GO:0005315") AnnotationAssertion(rdfs:label "phosphate transmembrane transporter activity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) -SubClassOf( ObjectSomeValuesFrom( )) # Class: (lipid transporter activity) @@ -27997,7 +27501,6 @@ SubClassOf( ObjectSomeValuesFrom( (ATP transmembrane transporter activity) AnnotationAssertion(Annotation( "GOC:ai") "Enables the transfer of ATP, adenosine triphosphate, from one side of a membrane to the other.") -AnnotationAssertion( "GO:0005348") AnnotationAssertion(Annotation(rdfs:label "CALHM1:CALHM3 transports ATP from the cytosol to the extracellular region") "Reactome:R-HSA-9717392") AnnotationAssertion( "molecular_function") AnnotationAssertion( "GO:0005347") @@ -28019,9 +27522,6 @@ SubClassOf( ObjectSomeValuesFrom( "GOC:ai") "Enables the transfer of iron (Fe) ions from one side of a membrane to the other.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/17162"^^xsd:anyURI) -AnnotationAssertion( "GO:0005382") -AnnotationAssertion( "GO:0016033") -AnnotationAssertion( "GO:0097689") AnnotationAssertion(Annotation(rdfs:label "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol") "Reactome:R-HSA-435349") AnnotationAssertion(Annotation(rdfs:label "Defective SLC11A2 does not cotransport Fe2+, H+ from extracellular region to cytosol") "Reactome:R-HSA-5623558") AnnotationAssertion(Annotation(rdfs:label "Defective SLC40A1 does not transport Fe2+ from cytosol to extracellular region") "Reactome:R-HSA-5655733") @@ -28092,8 +27592,7 @@ EquivalentClasses( ObjectIntersection # Class: (protein binding) AnnotationAssertion(Annotation( "GOC:go_curators") "Binding to a protein.") -AnnotationAssertion( "GO:0001948") -AnnotationAssertion( "GO:0045308") +AnnotationAssertion(Annotation(rdfs:label "Intermediate II binds CYC1, UQCRC1, UQCRC2, UQCRH") "Reactome:R-HSA-9866132") AnnotationAssertion( "protein amino acid binding") AnnotationAssertion( "glycoprotein binding") AnnotationAssertion( "molecular_function") @@ -28160,7 +27659,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:pdt") "A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex).") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/17729"^^xsd:anyURI) -AnnotationAssertion( "GO:0008372") AnnotationAssertion( "NIF_Subcellular:sao1337158144") AnnotationAssertion( "cell or subcellular entity") AnnotationAssertion( "cellular component") @@ -28274,8 +27772,6 @@ SubClassOf( ObjectSomeValuesFrom( (basement membrane) AnnotationAssertion(Annotation( "ISBN:0198547684") Annotation( "PMID:22505934") "A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.") -AnnotationAssertion( "GO:0005605") -AnnotationAssertion( "GO:0008003") AnnotationAssertion( "Wikipedia:Basement_membrane") AnnotationAssertion( "cellular_component") AnnotationAssertion( "basal lamina") @@ -28355,7 +27851,6 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (nuclear envelope) AnnotationAssertion(Annotation( "ISBN:0198547684") "The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).") -AnnotationAssertion( "GO:0005636") AnnotationAssertion( "Wikipedia:Nuclear_envelope") AnnotationAssertion( "cellular_component") AnnotationAssertion( "GO:0005635") @@ -28381,22 +27876,6 @@ SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) -# Class: (transcription regulator complex) - -AnnotationAssertion(Annotation( "GOC:jl") "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.") -AnnotationAssertion( "jl") -AnnotationAssertion( "2013-08-28T12:11:37Z") -AnnotationAssertion( "GO:0044797") -AnnotationAssertion( "GO:0044798") -AnnotationAssertion( "cellular_component") -AnnotationAssertion( "cytoplasmic transcription factor complex") -AnnotationAssertion( "nuclear transcription factor complex") -AnnotationAssertion( "transcription factor complex") -AnnotationAssertion( "GO:0005667") -AnnotationAssertion( ) -AnnotationAssertion(rdfs:label "transcription regulator complex") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) - # Class: (chromosome) AnnotationAssertion(Annotation( "ISBN:0198547684") "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.") @@ -28585,6 +28064,38 @@ AnnotationAssertion(rdfs:comment "No AnnotationAssertion(rdfs:label "Golgi-associated vesicle") SubClassOf( ) +# Class: (centriole) + +AnnotationAssertion(Annotation( "ISBN:0198547684") "A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle.") +AnnotationAssertion( "NIF_Subcellular:sao95019936") +AnnotationAssertion( "Wikipedia:Centriole") +AnnotationAssertion(Annotation( "GOC:cilia") "daughter centriole") +AnnotationAssertion(Annotation( "GOC:cilia") "mother centriole") +AnnotationAssertion( "cellular_component") +AnnotationAssertion( "GO:0005814") +AnnotationAssertion(rdfs:comment "In most eukaryotic cells, 'ciliary basal body' (GO:0036064) and 'centriole' (GO:0005814) represent a common entity that cycles through its function in cell division, then ciliogenesis, then cell division again. However, these structures are modified extensively as they transition into each other, and may contain different proteins, specific to each component.") +AnnotationAssertion(rdfs:label "centriole") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (microtubule organizing center) + +AnnotationAssertion(Annotation( "GOC:vw") Annotation( "ISBN:0815316194") Annotation( "PMID:17072892") Annotation( "PMID:17245416") Annotation( "Wikipedia:Microtubule_organizing_center") "An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.") +AnnotationAssertion( "Wikipedia:Microtubule_organizing_center") +AnnotationAssertion( "MTOC") +AnnotationAssertion( "microtubule organising centre") +AnnotationAssertion( "cellular_component") +AnnotationAssertion( "GO:0005815") +AnnotationAssertion( ) +AnnotationAssertion( ) +AnnotationAssertion( ) +AnnotationAssertion( ) +AnnotationAssertion( ) +AnnotationAssertion(rdfs:label "microtubule organizing center") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (cytosol) AnnotationAssertion(Annotation( "GOC:hjd") Annotation( "GOC:jl") "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.") @@ -28609,7 +28120,6 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (ribosome) AnnotationAssertion(Annotation( "ISBN:0198506732") "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.") -AnnotationAssertion( "GO:0033279") AnnotationAssertion( "NIF_Subcellular:sao1429207766") AnnotationAssertion( "Wikipedia:Ribosome") AnnotationAssertion(Annotation( "NIF_Subcellular:sao1139385046") "free ribosome") @@ -28760,8 +28270,6 @@ SubClassOf( ObjectSomeValuesFrom( (plasma membrane) AnnotationAssertion(Annotation( "ISBN:0716731363") "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.") -AnnotationAssertion( "GO:0005887") -AnnotationAssertion( "GO:0005904") AnnotationAssertion( "juxtamembrane") AnnotationAssertion( "NIF_Subcellular:sao1663586795") AnnotationAssertion( "Wikipedia:Cell_membrane") @@ -28883,7 +28391,6 @@ AnnotationAssertion( ) AnnotationAssertion( ) AnnotationAssertion( ) -AnnotationAssertion( "GO:0072372") AnnotationAssertion( "FMA:67181") AnnotationAssertion( "NIF_Subcellular:sao787716553") AnnotationAssertion( "Wikipedia:Cilium") @@ -28926,8 +28433,6 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (axoneme) AnnotationAssertion(Annotation( "GOC:bf") Annotation( "GOC:cilia") Annotation( "ISBN:0198547684") "The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.") -AnnotationAssertion( "GO:0035085") -AnnotationAssertion( "GO:0035086") AnnotationAssertion( "Wikipedia:Axoneme") AnnotationAssertion( "ciliary axoneme") AnnotationAssertion( "cilium axoneme") @@ -28965,8 +28470,6 @@ AnnotationAssertion(Annotation( "https://github.com/geneontology/go-ontology/issues/22880"^^xsd:anyURI) AnnotationAssertion( "jl") AnnotationAssertion( "2012-10-23T15:40:34Z") -AnnotationAssertion( "GO:0044261") -AnnotationAssertion( "GO:0044723") AnnotationAssertion( "Wikipedia:Carbohydrate_metabolism") AnnotationAssertion( "carbohydrate metabolism") AnnotationAssertion( "biological_process") @@ -28990,7 +28493,6 @@ SubClassOf( (polysaccharide metabolic process) AnnotationAssertion(Annotation( "ISBN:0198547684") "The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.") -AnnotationAssertion( "GO:0044263") AnnotationAssertion( "polysaccharide metabolism") AnnotationAssertion( "glycan metabolic process") AnnotationAssertion( "glycan metabolism") @@ -29018,6 +28520,7 @@ SubClassOf( "ISBN:0198506732") "The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/27107"^^xsd:anyURI) AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/28527"^^xsd:anyURI) +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/28968"^^xsd:anyURI) AnnotationAssertion(Annotation( "skos:narrowMatch") "MetaCyc:GLYCOGENSYNTH-PWY") AnnotationAssertion(Annotation( "skos:narrowMatch") "MetaCyc:PWY-5067") AnnotationAssertion(Annotation( "skos:narrowMatch") "MetaCyc:PWY-7900") @@ -29029,8 +28532,6 @@ AnnotationAssertion( "GO:0005978") AnnotationAssertion(rdfs:label "glycogen biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) -SubClassOf( ) # Class: (regulation of glycogen biosynthetic process) @@ -29132,20 +28633,18 @@ AnnotationAssertion( "proteoglycan metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -# Class: (cellular aldehyde metabolic process) +# Class: (aldehyde metabolic process) AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "ISBN:0198506732") "The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells.") +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/28908"^^xsd:anyURI) AnnotationAssertion( "aldehyde metabolism") AnnotationAssertion( "alkanal metabolic process") AnnotationAssertion( "alkanal metabolism") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0006081") AnnotationAssertion( ) -AnnotationAssertion(rdfs:label "cellular aldehyde metabolic process") +AnnotationAssertion(rdfs:label "aldehyde metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) -SubClassOf( ) -SubClassOf( ) # Class: (organic acid metabolic process) @@ -29157,7 +28656,6 @@ AnnotationAssertion( "organic acid metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) -SubClassOf( ) SubClassOf( ) # Class: (generation of precursor metabolites and energy) @@ -29182,12 +28680,15 @@ AnnotationAssertion( ) AnnotationAssertion( ) AnnotationAssertion(rdfs:label "generation of precursor metabolites and energy") -SubClassOf( ) +SubClassOf( ) # Class: (gluconeogenesis) AnnotationAssertion(Annotation( "MetaCyc:GLUCONEO-PWY") "The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.") -AnnotationAssertion( "MetaCyc:GLUCONEO-PWY") +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/28953"^^xsd:anyURI) +AnnotationAssertion(Annotation( "skos:narrowMatch") "MetaCyc:GLUCONEO-PWY") +AnnotationAssertion(Annotation( "skos:narrowMatch") "MetaCyc:PWY-6142") +AnnotationAssertion(Annotation( "skos:narrowMatch") "MetaCyc:PWY66-399") AnnotationAssertion( "Wikipedia:Gluconeogenesis") AnnotationAssertion( "glucose biosynthesis") AnnotationAssertion( "glucose biosynthetic process") @@ -29211,7 +28712,6 @@ SubClassOf( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.") AnnotationAssertion( "tb") AnnotationAssertion( "2013-01-18T12:47:43Z") -AnnotationAssertion( "GO:0090526") AnnotationAssertion( "regulation of glucose biosynthesis") AnnotationAssertion( "regulation of glucose biosynthetic process") AnnotationAssertion( "biological_process") @@ -29233,7 +28733,6 @@ SubClassOf( (nucleobase-containing compound metabolic process) AnnotationAssertion(Annotation( "GOC:ai") "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.") -AnnotationAssertion( "GO:0055134") AnnotationAssertion( "cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolic process") AnnotationAssertion( "cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolism") AnnotationAssertion( "nucleobase, nucleoside, nucleotide and nucleic acid metabolism") @@ -29262,7 +28761,6 @@ EquivalentClasses( ObjectIntersection # Class: (DNA metabolic process) AnnotationAssertion(Annotation( "ISBN:0198506732") "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.") -AnnotationAssertion( "GO:0055132") AnnotationAssertion( "DNA metabolism") AnnotationAssertion( "cellular DNA metabolism") AnnotationAssertion( "biological_process") @@ -29296,7 +28794,6 @@ SubClassOf( ObjectSomeValuesFrom( "GOC:dph") Annotation( "GOC:mah") Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:tb") Annotation( "ISBN:0721639976") Annotation( "PMID:15723341") Annotation( "PMID:23379520") "The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/24396"^^xsd:anyURI) -AnnotationAssertion( "GO:0008178") AnnotationAssertion( "DNA fragmentation") AnnotationAssertion(Annotation( "GOC:mtg_apoptosis") "chromatinolysis") AnnotationAssertion( "DNA catabolic process during apoptosis") @@ -29328,11 +28825,6 @@ SubClassOf( "PMID:20404130") "The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/22130"^^xsd:anyURI) AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/23549"^^xsd:anyURI) -AnnotationAssertion( "GO:0006333") -AnnotationAssertion( "GO:0006336") -AnnotationAssertion( "GO:0016568") -AnnotationAssertion( "GO:0031497") -AnnotationAssertion( "GO:0034724") AnnotationAssertion( "chromatin maintenance") AnnotationAssertion(Annotation( "GOC:mah") "chromatin organisation") AnnotationAssertion(Annotation( "GOC:mah") "establishment of chromatin architecture") @@ -29354,95 +28846,6 @@ AnnotationAssertion( "chromatin organization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -# Class: (DNA-templated transcription) - -AnnotationAssertion(Annotation( "GOC:jl") Annotation( "GOC:txnOH") "The synthesis of an RNA transcript from a DNA template.") -AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/14854"^^xsd:anyURI) -AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/16737"^^xsd:anyURI) -AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/22258"^^xsd:anyURI) -AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/22555"^^xsd:anyURI) -AnnotationAssertion( "GO:0001121") -AnnotationAssertion( "GO:0006350") -AnnotationAssertion( "GO:0061018") -AnnotationAssertion( "GO:0061022") -AnnotationAssertion( "cellular transcription") -AnnotationAssertion( "transcription") -AnnotationAssertion( "Wikipedia:Transcription_(genetics)") -AnnotationAssertion( "DNA-dependent transcription") -AnnotationAssertion(Annotation( "GOC:txnOH") "transcription, DNA-dependent") -AnnotationAssertion( "transcription, DNA-templated") -AnnotationAssertion( "bacterial transcription") -AnnotationAssertion( "transcription from bacterial-type RNA polymerase promoter") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "GO:0006351") -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion(rdfs:label "DNA-templated transcription") -SubClassOf( ObjectSomeValuesFrom( )) - -# Class: (regulation of DNA-templated transcription) - -AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "GOC:txnOH") "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.") -AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/25256"^^xsd:anyURI) -AnnotationAssertion( "GO:0032583") -AnnotationAssertion( "GO:0045449") -AnnotationAssertion( "GO:0061019") -AnnotationAssertion( "transcriptional control") -AnnotationAssertion( "regulation of cellular transcription, DNA-dependent") -AnnotationAssertion(Annotation( "GOC:txnOH") "regulation of transcription, DNA-dependent") -AnnotationAssertion( "regulation of transcription, DNA-templated") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "regulation of gene-specific transcription") -AnnotationAssertion( "GO:0006355") -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion(rdfs:label "regulation of DNA-templated transcription") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) - -# Class: (regulation of transcription by RNA polymerase II) - -AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "GOC:txnOH") "Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.") -AnnotationAssertion( "GO:0006358") -AnnotationAssertion( "GO:0010551") -AnnotationAssertion( "regulation of transcription from Pol II promoter") -AnnotationAssertion( "regulation of transcription from RNA polymerase II promoter") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "global transcription regulation from Pol II promoter") -AnnotationAssertion( "regulation of gene-specific transcription from RNA polymerase II promoter") -AnnotationAssertion( "regulation of global transcription from Pol II promoter") -AnnotationAssertion( "regulation of transcription from RNA polymerase II promoter, global") -AnnotationAssertion( "GO:0006357") -AnnotationAssertion(rdfs:label "regulation of transcription by RNA polymerase II") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) - -# Class: (transcription by RNA polymerase II) - -AnnotationAssertion(Annotation( "GOC:jl") Annotation( "GOC:txnOH") Annotation( "ISBN:0321000382") "The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).") -AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/14854"^^xsd:anyURI) -AnnotationAssertion( "GO:0032568") -AnnotationAssertion( "GO:0032569") -AnnotationAssertion( "transcription from Pol II promoter") -AnnotationAssertion( "transcription from RNA polymerase II promoter") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "RNA polymerase II transcription factor activity") -AnnotationAssertion( "gene-specific transcription from RNA polymerase II promoter") -AnnotationAssertion( "general transcription from RNA polymerase II promoter") -AnnotationAssertion(Annotation( "GOC:mah") "specific transcription from RNA polymerase II promoter") -AnnotationAssertion( "GO:0006366") -AnnotationAssertion( ) -AnnotationAssertion(rdfs:label "transcription by RNA polymerase II") -SubClassOf( ) - # Class: (RNA catabolic process) AnnotationAssertion(Annotation( "ISBN:0198506732") "The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.") @@ -29492,9 +28895,6 @@ EquivalentClasses( ObjectIntersection # Class: (translation) AnnotationAssertion(Annotation( "GOC:go_curators") "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.") -AnnotationAssertion( "GO:0006416") -AnnotationAssertion( "GO:0006453") -AnnotationAssertion( "GO:0043037") AnnotationAssertion( "Wikipedia:Translation_(genetics)") AnnotationAssertion( "protein anabolism") AnnotationAssertion( "protein biosynthesis") @@ -29525,8 +28925,6 @@ SubClassOf( ObjectSomeValuesFrom( (translational initiation) AnnotationAssertion(Annotation( "ISBN:019879276X") "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.") -AnnotationAssertion( "GO:0006440") -AnnotationAssertion( "GO:0006454") AnnotationAssertion( "biopolymerisation") AnnotationAssertion( "biopolymerization") AnnotationAssertion( "protein synthesis initiation") @@ -29535,15 +28933,13 @@ AnnotationAssertion( "GO:0006413") AnnotationAssertion( ) AnnotationAssertion(rdfs:label "translational initiation") -SubClassOf( ) +SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) # Class: (translational elongation) AnnotationAssertion(Annotation( "GOC:ems") "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis.") -AnnotationAssertion( "GO:0006442") -AnnotationAssertion( "GO:0006455") AnnotationAssertion( "protein synthesis elongation") AnnotationAssertion( "translation elongation") AnnotationAssertion( "biological_process") @@ -29556,8 +28952,6 @@ SubClassOf( ObjectSomeValuesFrom( (translational termination) AnnotationAssertion(Annotation( "GOC:hjd") Annotation( "ISBN:019879276X") "The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code).") -AnnotationAssertion( "GO:0006443") -AnnotationAssertion( "GO:0006456") AnnotationAssertion( "protein synthesis termination") AnnotationAssertion( "translation termination") AnnotationAssertion( "translational complex disassembly") @@ -29570,7 +28964,6 @@ SubClassOf( ObjectSomeValuesFrom( (regulation of translation) AnnotationAssertion(Annotation( "GOC:isa_complete") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.") -AnnotationAssertion( "GO:0006445") AnnotationAssertion( "regulation of protein anabolism") AnnotationAssertion( "regulation of protein biosynthesis") AnnotationAssertion( "regulation of protein formation") @@ -29676,7 +29069,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "ISBN:0198506732") "The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/17904"^^xsd:anyURI) -AnnotationAssertion( "GO:0006519") AnnotationAssertion( "cellular amino acid metabolic process") AnnotationAssertion( "cellular amino acid metabolism") AnnotationAssertion( "biological_process") @@ -29695,17 +29087,15 @@ AnnotationAssertion(rdfs:label "amin EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) -# Class: (regulation of cellular amino acid metabolic process) +# Class: (regulation of amino acid metabolic process) AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids.") +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/28908"^^xsd:anyURI) AnnotationAssertion( "regulation of amino acid metabolism") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0006521") -AnnotationAssertion(rdfs:label "regulation of cellular amino acid metabolic process") +AnnotationAssertion(rdfs:label "regulation of amino acid metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) -SubClassOf( ) -SubClassOf( ) # Class: (glutamate metabolic process) @@ -29743,7 +29133,6 @@ SubClassOf( (glutamate catabolic process) AnnotationAssertion(Annotation( "GOC:go_curators") "The chemical reactions and pathways resulting in the breakdown of glutamate, the anion of 2-aminopentanedioic acid.") -AnnotationAssertion( "GO:0019459") AnnotationAssertion( "glutamate breakdown") AnnotationAssertion( "glutamate catabolism") AnnotationAssertion( "glutamate degradation") @@ -29815,23 +29204,23 @@ AnnotationAssertion( "L-histidine catabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -# Class: (cellular modified amino acid metabolic process) +# Class: (modified amino acid metabolic process) AnnotationAssertion(Annotation( "GOC:ai") "The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents.") +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/28908"^^xsd:anyURI) AnnotationAssertion( "amino acid derivative metabolic process") AnnotationAssertion( "cellular amino acid derivative metabolic process") AnnotationAssertion( "cellular amino acid derivative metabolism") +AnnotationAssertion(Annotation( "GOC:mah") "cellular modified amino acid metabolic process") AnnotationAssertion(Annotation( "GOC:mah") "cellular modified amino acid metabolism") -AnnotationAssertion(Annotation( "GOC:mah") "modified amino acid metabolic process") AnnotationAssertion(Annotation( "GOC:mah") "modified amino acid metabolism") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0006575") AnnotationAssertion( ) AnnotationAssertion( ) AnnotationAssertion( ) -AnnotationAssertion(rdfs:label "cellular modified amino acid metabolic process") +AnnotationAssertion(rdfs:label "modified amino acid metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) # Class: (biogenic amine metabolic process) @@ -29889,7 +29278,6 @@ EquivalentClasses( ObjectIntersection # Class: (protein export from nucleus) AnnotationAssertion(Annotation( "GOC:jl") "The directed movement of a protein from the nucleus into the cytoplasm.") -AnnotationAssertion( "GO:0097349") AnnotationAssertion( "protein export from cell nucleus") AnnotationAssertion( "protein export out of nucleus") AnnotationAssertion( "protein transport from nucleus to cytoplasm") @@ -29938,6 +29326,16 @@ EquivalentClasses( ObjectIntersection SubClassOf( ) SubClassOf( ) +# Class: (membrane lipid metabolic process) + +AnnotationAssertion(Annotation( "GOC:ai") "The chemical reactions and pathways involving membrane lipids, any lipid found in or associated with a biological membrane.") +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/28908"^^xsd:anyURI) +AnnotationAssertion( "membrane lipid metabolism") +AnnotationAssertion( "biological_process") +AnnotationAssertion( "GO:0006643") +AnnotationAssertion(rdfs:label "membrane lipid metabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) + # Class: (glycosphingolipid metabolic process) AnnotationAssertion(Annotation( "ISBN:0198547684") "The chemical reactions and pathways involving glycosphingolipids, any compound with residues of sphingoid and at least one monosaccharide.") @@ -30007,7 +29405,6 @@ EquivalentClasses( ObjectIntersection SubClassOf( ) SubClassOf( ) SubClassOf( ) -SubClassOf( ) # Class: (progesterone biosynthetic process) @@ -30129,8 +29526,6 @@ SubClassOf( (ATP biosynthetic process) AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "ISBN:0198506732") "The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.") -AnnotationAssertion( "GO:0006758") -AnnotationAssertion( "GO:0006759") AnnotationAssertion( "ATP anabolism") AnnotationAssertion( "ATP biosynthesis") AnnotationAssertion( "ATP formation") @@ -30183,9 +29578,6 @@ AnnotationAssertion(Annotation( "https://github.com/geneontology/go-ontology/issues/20292"^^xsd:anyURI) AnnotationAssertion( "jl") AnnotationAssertion( "2012-12-13T16:25:32Z") -AnnotationAssertion( "GO:0015457") -AnnotationAssertion( "GO:0015460") -AnnotationAssertion( "GO:0044765") AnnotationAssertion( "biological_process") AnnotationAssertion( "single-organism transport") AnnotationAssertion( "GO:0006810") @@ -30217,9 +29609,6 @@ EquivalentClasses( ObjectIntersection # Class: (monoatomic cation transport) AnnotationAssertion(Annotation( "GOC:ai") "The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom.") -AnnotationAssertion( "GO:0006819") -AnnotationAssertion( "GO:0015674") -AnnotationAssertion( "GO:0072512") AnnotationAssertion( "cation transport") AnnotationAssertion(Annotation( "GOC:mah") "di-, tri-valent inorganic cation transport") AnnotationAssertion( "trivalent inorganic cation transport") @@ -30233,8 +29622,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:ai") "The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") AnnotationAssertion( "mah") AnnotationAssertion( "2010-09-03T02:39:22Z") -AnnotationAssertion( "GO:0015458") -AnnotationAssertion( "GO:0071804") AnnotationAssertion( "sodium/potassium transport") AnnotationAssertion( "cellular potassium ion transport") AnnotationAssertion( "potassium conductance") @@ -30251,8 +29638,6 @@ EquivalentClasses( ObjectIntersection # Class: (sodium ion transport) AnnotationAssertion(Annotation( "GOC:ai") "The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") -AnnotationAssertion( "GO:0006834") -AnnotationAssertion( "GO:0016974") AnnotationAssertion( "sodium/potassium transport") AnnotationAssertion( "sodium transport") AnnotationAssertion( "mitochondrial sodium/calcium ion exchange") @@ -30289,11 +29674,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:ai") "The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") AnnotationAssertion( "pr") AnnotationAssertion( "2012-04-18T03:33:45Z") -AnnotationAssertion( "GO:0015681") -AnnotationAssertion( "GO:0015682") -AnnotationAssertion( "GO:0015684") -AnnotationAssertion( "GO:0033216") -AnnotationAssertion( "GO:0097286") AnnotationAssertion( "iron transport") AnnotationAssertion( "ferric ion import") AnnotationAssertion( "ferric ion transport") @@ -30320,7 +29700,6 @@ SubClassOf( (dicarboxylic acid transport) AnnotationAssertion(Annotation( "GOC:krc") "The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") -AnnotationAssertion( "GO:0006841") AnnotationAssertion( "biological_process") AnnotationAssertion( "sodium:dicarboxylate transport") AnnotationAssertion( "GO:0006835") @@ -30366,7 +29745,6 @@ EquivalentClasses( ObjectIntersection # Class: (amino acid transport) AnnotationAssertion(Annotation( "GOC:ai") "The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") -AnnotationAssertion( "GO:0006866") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0006865") AnnotationAssertion( ) @@ -30441,7 +29819,6 @@ SubClassOf( (intracellular protein transport) AnnotationAssertion(Annotation( "GOC:mah") "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.") -AnnotationAssertion( "GO:0032779") AnnotationAssertion( "biological_process") AnnotationAssertion(Annotation( "GOC:al") "copper-induced intracellular protein transport") AnnotationAssertion( "GO:0006886") @@ -30454,8 +29831,6 @@ SubClassOf( ObjectSomeValuesFrom( (exocytosis) AnnotationAssertion(Annotation( "GOC:mah") Annotation( "ISBN:0716731363") Annotation( "PMID:22323285") "A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for example of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.") -AnnotationAssertion( "GO:0016194") -AnnotationAssertion( "GO:0016195") AnnotationAssertion( "Wikipedia:Exocytosis") AnnotationAssertion( "vesicle exocytosis") AnnotationAssertion( "biological_process") @@ -30502,9 +29877,6 @@ SubClassOf( "GOC:mah") Annotation( "ISBN:0198506732") Annotation( "ISBN:0716731363") Annotation( "Wikipedia:Endocytosis") "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a part of the plasma membrane to form a new membrane-bounded vesicle.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/24907"^^xsd:anyURI) AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/25268"^^xsd:anyURI) -AnnotationAssertion( "GO:0016193") -AnnotationAssertion( "GO:0016196") -AnnotationAssertion( "GO:0098701") AnnotationAssertion( "Wikipedia:Endocytosis") AnnotationAssertion( "endocytic import into cell") AnnotationAssertion( "vesicle endocytosis") @@ -30526,8 +29898,6 @@ SubClassOf( ObjectSomeValuesFrom( "GOC:jid") Annotation( "GOC:tb") "The evagination of a membrane, resulting in formation of a vesicle.") AnnotationAssertion( "jl") AnnotationAssertion( "2013-12-19T15:26:17Z") -AnnotationAssertion( "GO:0006902") -AnnotationAssertion( "GO:1902591") AnnotationAssertion( "membrane evagination") AnnotationAssertion( "vesicle biosynthesis") AnnotationAssertion( "vesicle formation") @@ -30582,7 +29952,6 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (nucleocytoplasmic transport) AnnotationAssertion(Annotation( "GOC:go_curators") "The directed movement of molecules between the nucleus and the cytoplasm.") -AnnotationAssertion( "GO:0000063") AnnotationAssertion( "nucleocytoplasmic shuttling") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0006913") @@ -30600,8 +29969,6 @@ SubClassOf( "GOC:cjm") Annotation( "GOC:dhl") Annotation( "GOC:ecd") Annotation( "GOC:go_curators") Annotation( "GOC:mtg_apoptosis") Annotation( "GOC:tb") Annotation( "ISBN:0198506732") Annotation( "PMID:18846107") Annotation( "PMID:21494263") "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.") AnnotationAssertion( ) AnnotationAssertion( ) -AnnotationAssertion( "GO:0006917") -AnnotationAssertion( "GO:0008632") AnnotationAssertion( "cell suicide") AnnotationAssertion( "cellular suicide") AnnotationAssertion( "Wikipedia:Apoptosis") @@ -30760,8 +30127,6 @@ SubClassOf( (defense response) AnnotationAssertion(Annotation( "GOC:go_curators") "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.") -AnnotationAssertion( "GO:0002217") -AnnotationAssertion( "GO:0042829") AnnotationAssertion( "defence response") AnnotationAssertion( "physiological defense response") AnnotationAssertion( "biological_process") @@ -30809,7 +30174,6 @@ AnnotationAssertion(Annotation( "https://github.com/geneontology/go-ontology/issues/27189"^^xsd:anyURI) AnnotationAssertion( "jl") AnnotationAssertion( "2013-12-19T15:25:51Z") -AnnotationAssertion( "GO:1902589") AnnotationAssertion( "organelle organisation") AnnotationAssertion(Annotation( "GOC:TermGenie") "single organism organelle organization") AnnotationAssertion( "biological_process") @@ -30826,7 +30190,6 @@ EquivalentClasses( ObjectIntersection # Class: (nucleus organization) AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:ems") Annotation( "GOC:jl") Annotation( "GOC:mah") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus.") -AnnotationAssertion( "GO:0048287") AnnotationAssertion( "nuclear organisation") AnnotationAssertion( "nuclear organization") AnnotationAssertion( "biological_process") @@ -31005,7 +30368,6 @@ SubClassOf( ObjectSomeValuesFrom( (vacuole organization) AnnotationAssertion(Annotation( "GOC:mah") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole.") -AnnotationAssertion( "GO:0044086") AnnotationAssertion( "vacuole organisation") AnnotationAssertion(Annotation( "GOC:mah") "vacuolar assembly") AnnotationAssertion( "biological_process") @@ -31090,7 +30452,6 @@ EquivalentClasses( ObjectIntersection # Class: (cell-substrate junction assembly) AnnotationAssertion(Annotation( "GOC:mah") "The aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate.") -AnnotationAssertion( "GO:0007045") AnnotationAssertion( "biological_process") AnnotationAssertion( "cell-substrate adherens junction assembly") AnnotationAssertion( "GO:0007044") @@ -31171,7 +30532,6 @@ SubClassOf( ObjectSomeValuesFrom( (nuclear migration) AnnotationAssertion(Annotation( "GOC:ai") "The directed movement of the nucleus to a specific location within a cell.") -AnnotationAssertion( "GO:0040023") AnnotationAssertion( "establishment of position of nucleus") AnnotationAssertion( "nuclear movement") AnnotationAssertion( "nuclear positioning") @@ -31277,7 +30637,6 @@ SubClassOf( "GOC:hb") Annotation( "GOC:pf") "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.") AnnotationAssertion( "dos") AnnotationAssertion( "2014-04-15T15:59:10Z") -AnnotationAssertion( "GO:0098602") AnnotationAssertion( "Wikipedia:Cell_adhesion") AnnotationAssertion( "biological_process") AnnotationAssertion( "cell adhesion molecule activity") @@ -31327,8 +30686,6 @@ SubClassOf( (establishment or maintenance of cell polarity) AnnotationAssertion(Annotation( "GOC:mah") "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.") -AnnotationAssertion( "GO:0030012") -AnnotationAssertion( "GO:0030467") AnnotationAssertion( "biological_process") AnnotationAssertion(Annotation( "GOC:mah") Annotation( "GOC:vw") "cell polarity") AnnotationAssertion( "establishment and/or maintenance of cell polarity") @@ -31344,11 +30701,6 @@ SubClassOf( (signal transduction) AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "GOC:mtg_signaling_feb11") "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.") -AnnotationAssertion( "GO:0023014") -AnnotationAssertion( "GO:0023015") -AnnotationAssertion( "GO:0023016") -AnnotationAssertion( "GO:0023033") -AnnotationAssertion( "GO:0023045") AnnotationAssertion( "Wikipedia:Signal_transduction") AnnotationAssertion( "signaling cascade") AnnotationAssertion( "signalling cascade") @@ -31405,7 +30757,6 @@ SubClassOf( (G protein-coupled receptor signaling pathway) AnnotationAssertion(Annotation( "GOC:bf") Annotation( "GOC:mah") Annotation( "PMID:16902576") Annotation( "PMID:24568158") Annotation( "Wikipedia:G_protein-coupled_receptor") "The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane.") -AnnotationAssertion( "GO:0038042") AnnotationAssertion( "G protein coupled receptor protein signaling pathway") AnnotationAssertion( "G protein coupled receptor protein signalling pathway") AnnotationAssertion( "G-protein coupled receptor protein signal transduction") @@ -31528,7 +30879,6 @@ SubClassOf( ObjectSomeValuesFrom( (neurotransmitter secretion) AnnotationAssertion(Annotation( "GOC:dph") "The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission.") -AnnotationAssertion( "GO:0010554") AnnotationAssertion( "neurotransmitter release") AnnotationAssertion( "neurotransmitter secretory pathway") AnnotationAssertion( "biological_process") @@ -31592,7 +30942,6 @@ AnnotationAssertion(Annotation( ) AnnotationAssertion( ) AnnotationAssertion( ) -AnnotationAssertion( "GO:0009552") AnnotationAssertion( "biological_process") AnnotationAssertion( "gametogenesis") AnnotationAssertion( "GO:0007276") @@ -31774,7 +31123,6 @@ SubClassOf( (oocyte construction) AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:ems") Annotation( "GOC:mtg_sensu") Annotation( "GOC:tb") Annotation( "ISBN:0198506732") "The synthesis, deposition, and organization of the materials in a cell of an ovary; where the cell can then undergo meiosis and form an ovum. An example of this is found in Drosophila melanogaster.") -AnnotationAssertion( "GO:0048110") AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "oocyte arrangement") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0007308") @@ -31787,7 +31135,6 @@ SubClassOf( ObjectSomeValuesFrom( (oocyte axis specification) AnnotationAssertion(Annotation( "GOC:mtg_sensu") Annotation( "ISBN:0879694238") "The establishment, maintenance and elaboration of an axis in the oocyte. An example of this is found in Drosophila melanogaster.") -AnnotationAssertion( "GO:0048111") AnnotationAssertion( "biological_process") AnnotationAssertion( "oocyte axis determination") AnnotationAssertion( "GO:0007309") @@ -31800,7 +31147,6 @@ SubClassOf( ObjectSomeValuesFrom( (oocyte anterior/posterior axis specification) AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_sensu") Annotation( "GOC:tb") Annotation( "ISBN:0879694238") "Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster.") -AnnotationAssertion( "GO:0048112") AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "oocyte anterior/posterior axis determination") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0007314") @@ -31866,7 +31212,6 @@ EquivalentClasses( ObjectIntersection # Class: (cellularization) AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "GOC:mtg_sensu") Annotation( "ISBN:0716731363") "The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development.") -AnnotationAssertion( "GO:0009796") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0007349") AnnotationAssertion(rdfs:label "cellularization") @@ -31961,8 +31306,6 @@ SubClassOf( (neuroblast proliferation) AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:mtg_sensu") Annotation( "GOC:sart") "The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron.") -AnnotationAssertion( "GO:0043349") -AnnotationAssertion( "GO:0043350") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0007405") AnnotationAssertion(rdfs:label "neuroblast proliferation") @@ -31989,8 +31332,6 @@ SubClassOf( (neuroblast activation) AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "GOC:mtg_sensu") "A change in the morphology or behavior of a neuroblast resulting from exposure to an activating factor such as a cellular or soluble ligand.") -AnnotationAssertion( "GO:0043351") -AnnotationAssertion( "GO:0043352") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0007407") AnnotationAssertion(rdfs:label "neuroblast activation") @@ -32003,7 +31344,6 @@ SubClassOf( ObjectAllValuesFrom( (axonogenesis) AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GOC:pg") Annotation( "GOC:pr") Annotation( "ISBN:0198506732") "De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells.") -AnnotationAssertion( "GO:0007410") AnnotationAssertion(Annotation( "GOC:bf") Annotation( "PMID:23517308") "axon morphogenesis") AnnotationAssertion(Annotation( ) "neuron long process generation") AnnotationAssertion( "axon growth") @@ -32250,7 +31590,6 @@ SubClassOf( ObjectSomeValuesFrom( "GOC:jid") Annotation( "UBERON:0000948") "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.") AnnotationAssertion( ) -AnnotationAssertion( "GO:0007511") AnnotationAssertion( "Wikipedia:Heart_development") AnnotationAssertion( "dorsal vessel development") AnnotationAssertion( "biological_process") @@ -32288,7 +31627,6 @@ SubClassOf( (skeletal muscle tissue development) AnnotationAssertion(Annotation( "GOC:mtg_muscle") "The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.") -AnnotationAssertion( "GO:0048637") AnnotationAssertion( "biological_process") AnnotationAssertion( "myogenesis") AnnotationAssertion( "GO:0007519") @@ -32319,8 +31657,6 @@ SubClassOf( (metamorphosis) AnnotationAssertion(Annotation( "GOC:sensu") Annotation( "ISBN:0198506732") Annotation( "ISBN:0721662544") "A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster.") -AnnotationAssertion( "GO:0046698") -AnnotationAssertion( "GO:0046699") AnnotationAssertion( "Wikipedia:Metamorphosis") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0007552") @@ -32394,7 +31730,6 @@ SubClassOf( ObjectSomeValuesFrom( (imaginal disc morphogenesis) AnnotationAssertion(Annotation( "GOC:jid") "The process in which the anatomical structures derived from an imaginal disc are generated and organized. The imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form.") -AnnotationAssertion( "GO:0007452") AnnotationAssertion( "imaginal disc metamorphosis") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0007560") @@ -32570,9 +31905,6 @@ SubClassOf( "GOC:ems") Annotation( "GOC:jl") Annotation( "ISBN:0395448956") Annotation( "PMID:20160973") "The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity.") AnnotationAssertion( "jl") AnnotationAssertion( "2012-09-20T14:06:08Z") -AnnotationAssertion( "GO:0023032") -AnnotationAssertion( "GO:0044708") -AnnotationAssertion( "GO:0044709") AnnotationAssertion( "Wikipedia:Behavior") AnnotationAssertion( "behavioral response to stimulus") AnnotationAssertion( "behaviour") @@ -32667,7 +31999,6 @@ SubClassOf( ObjectSomeValuesFrom( (blood circulation) AnnotationAssertion(Annotation( "GOC:mtg_heart") Annotation( "ISBN:0192800825") "The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products.") -AnnotationAssertion( "GO:0070261") AnnotationAssertion( "biological_process") AnnotationAssertion( "hemolymph circulation") AnnotationAssertion( "GO:0008015") @@ -32775,7 +32106,6 @@ AnnotationAssertion(Annotation( "https://github.com/geneontology/go-ontology/issues/20876"^^xsd:anyURI) AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/21612"^^xsd:anyURI) AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/21775"^^xsd:anyURI) -AnnotationAssertion( "GO:0004011") AnnotationAssertion( "ATPase activity, acting on DNA") AnnotationAssertion( "ATPase, acting on DNA") AnnotationAssertion( "DNA dependent ATPase activity") @@ -32791,9 +32121,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:ai") "Any process in which a protein is transported to, or maintained in, a specific location.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/23112"^^xsd:anyURI) -AnnotationAssertion( "GO:0008105") -AnnotationAssertion( "GO:0016249") -AnnotationAssertion( "GO:0034613") AnnotationAssertion(Annotation( "GOC:mah") "cellular protein localisation") AnnotationAssertion( "cellular protein localization") AnnotationAssertion(Annotation( "GOC:mah") "protein localisation") @@ -32834,9 +32161,6 @@ AnnotationAssertion(Annotation( "https://github.com/geneontology/go-ontology/issues/24968"^^xsd:anyURI) AnnotationAssertion( "jl") AnnotationAssertion( "2012-09-19T15:05:24Z") -AnnotationAssertion( "GO:0000004") -AnnotationAssertion( "GO:0007582") -AnnotationAssertion( "GO:0044699") AnnotationAssertion( "Wikipedia:Biological_process") AnnotationAssertion( "biological process") AnnotationAssertion( "physiological process") @@ -32857,19 +32181,14 @@ SubClassOf( (metabolic process) -AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "ISBN:0198547684") "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.") +AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "ISBN:0198547684") "A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/26424"^^xsd:anyURI) +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/28932"^^xsd:anyURI) AnnotationAssertion( "jl") AnnotationAssertion( "2012-10-17T15:46:40Z") -AnnotationAssertion( "GO:0044236") -AnnotationAssertion( "GO:0044710") AnnotationAssertion( "Wikipedia:Metabolism") AnnotationAssertion( "metabolism") -AnnotationAssertion( "metabolic process resulting in cell growth") -AnnotationAssertion( "metabolism resulting in cell growth") -AnnotationAssertion( "multicellular organism metabolic process") AnnotationAssertion( "biological_process") -AnnotationAssertion( "single-organism metabolic process") AnnotationAssertion( "GO:0008152") AnnotationAssertion( ) AnnotationAssertion( ) @@ -32880,7 +32199,7 @@ AnnotationAssertion( ) AnnotationAssertion(rdfs:comment "Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions.") AnnotationAssertion(rdfs:label "metabolic process") -SubClassOf( ) +SubClassOf( ) DisjointClasses( ) DisjointClasses( ) @@ -32889,7 +32208,6 @@ DisjointClasses( "GOC:jl") "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/20876"^^xsd:anyURI) AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/21775"^^xsd:anyURI) -AnnotationAssertion( "GO:0004010") AnnotationAssertion(Annotation(rdfs:label "Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new)") "Reactome:R-HSA-9770847") AnnotationAssertion(Annotation(rdfs:label "Disassembly of the Intron Lariat Spliceosome (new)") "Reactome:R-HSA-9772351") AnnotationAssertion( "ATPase activity, acting on RNA") @@ -33179,8 +32497,6 @@ SubClassOf( (protein transmembrane transporter activity) AnnotationAssertion(Annotation( "GOC:jl") "Enables the transfer of a protein from one side of a membrane to the other.") -AnnotationAssertion( "GO:0015266") -AnnotationAssertion( "GO:0015463") AnnotationAssertion(Annotation(rdfs:label "TOMM40 complex translocates proteins from the cytosol to the mitochondrial intermembrane space") "Reactome:R-HSA-1268022") AnnotationAssertion(Annotation(rdfs:label "TIMM23 PAM translocates proteins from the mitochondrial intermembrane space to the mitochondrial matrix") "Reactome:R-HSA-1299475") AnnotationAssertion(Annotation(rdfs:label "Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex") "Reactome:R-HSA-184269") @@ -33233,7 +32549,6 @@ SubClassOf( ObjectSomeValuesFrom( (glial cell migration) AnnotationAssertion(Annotation( "GOC:jl") Annotation( "GOC:mtg_sensu") "The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system.") -AnnotationAssertion( "GO:0043359") AnnotationAssertion( "glia cell migration") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0008347") @@ -33247,8 +32562,6 @@ SubClassOf( ObjectAllValuesFrom( (negative regulation of antimicrobial humoral response) AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate, or extent of an antimicrobial humoral response.") -AnnotationAssertion( "GO:0042154") -AnnotationAssertion( "GO:0042155") AnnotationAssertion( "attenuation of antimicrobial humoral response") AnnotationAssertion( "down regulation of antimicrobial humoral response") AnnotationAssertion( "down-regulation of antimicrobial humoral response") @@ -33304,7 +32617,6 @@ SubClassOf( (axon ensheathment) AnnotationAssertion(Annotation( "GOC:jl") Annotation( "ISBN:0878932437") "Any process in which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal.") -AnnotationAssertion( "GO:0042553") AnnotationAssertion( "cellular axon ensheathment") AnnotationAssertion( "biological_process") AnnotationAssertion( "cellular nerve ensheathment") @@ -33343,12 +32655,10 @@ AnnotationAssertion(Annotation( "https://github.com/geneontology/go-ontology/issues/22368"^^xsd:anyURI) AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/23129"^^xsd:anyURI) AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/26941"^^xsd:anyURI) -AnnotationAssertion( "GO:0015251") -AnnotationAssertion( "GO:0051739") +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/27521"^^xsd:anyURI) AnnotationAssertion( "ammonia transmembrane transporter activity") AnnotationAssertion( "ammonium transmembrane transporter activity") AnnotationAssertion( "MetaCyc:RXN-9615") -AnnotationAssertion( "RHEA:28747") AnnotationAssertion(Annotation(rdfs:label "RhCG mediates ammonium influx into kidney collecting duct cells") "Reactome:R-HSA-444393") AnnotationAssertion(Annotation(rdfs:label "RHAG transports NH4+ from cytosol to extracellular region (red blood cells)") "Reactome:R-HSA-444416") AnnotationAssertion(Annotation(rdfs:label "RhBG mediates ammonium effflux out of kidney collecting duct cells") "Reactome:R-HSA-444419") @@ -33361,7 +32671,6 @@ AnnotationAssertion( "ammonium channel activity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf(Annotation( "GO_REF:0000090") ObjectSomeValuesFrom( )) -SubClassOf( ObjectSomeValuesFrom( )) # Class: (G protein-coupled peptide receptor activity) @@ -33405,7 +32714,6 @@ SubClassOf( ObjectSomeValuesFrom( "GOC:dph") Annotation( "GOC:jid") Annotation( "GOC:tb") "The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure.") AnnotationAssertion( ) -AnnotationAssertion( "GO:0061039") AnnotationAssertion( "biological_process") AnnotationAssertion(Annotation( "GOC:sl") "ovarian development") AnnotationAssertion(Annotation( "GOC:sl") "ovary development") @@ -33457,8 +32765,6 @@ SubClassOf( (carbohydrate transport) AnnotationAssertion(Annotation( "GOC:ai") "The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y.") -AnnotationAssertion( "GO:0006861") -AnnotationAssertion( "GO:0008644") AnnotationAssertion( "sugar transport") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0008643") @@ -33473,9 +32779,6 @@ SubClassOf( "GOC:vw") "The process in which hexose is transported across a membrane. Hexoses are aldoses with a chain of six carbon atoms in the molecule.") AnnotationAssertion( "bf") AnnotationAssertion( "2010-04-08T10:27:23Z") -AnnotationAssertion( "GO:0008646") -AnnotationAssertion( "GO:0008647") -AnnotationAssertion( "GO:0035428") AnnotationAssertion( "high-affinity hexose transport") AnnotationAssertion( "low-affinity hexose transport") AnnotationAssertion( "biological_process") @@ -33504,18 +32807,18 @@ EquivalentClasses( ObjectIntersection # Class: (catabolic process) -AnnotationAssertion(Annotation( "ISBN:0198547684") "The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.") +AnnotationAssertion(Annotation( "ISBN:0198547684") "A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.") +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/28921"^^xsd:anyURI) +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/28932"^^xsd:anyURI) AnnotationAssertion( "jl") AnnotationAssertion( "2012-10-17T15:52:35Z") -AnnotationAssertion( "GO:0044243") -AnnotationAssertion( "GO:0044712") AnnotationAssertion( "Wikipedia:Catabolism") -AnnotationAssertion( "breakdown") +AnnotationAssertion( "breakdown of chemical") +AnnotationAssertion( "breakdown of molecule") +AnnotationAssertion( "breakdown of substance") AnnotationAssertion( "catabolism") AnnotationAssertion( "degradation") -AnnotationAssertion( "multicellular organismal catabolic process") AnnotationAssertion( "biological_process") -AnnotationAssertion( "single-organism catabolic process") AnnotationAssertion( "GO:0009056") AnnotationAssertion( ) AnnotationAssertion( ) @@ -33527,8 +32830,6 @@ SubClassOf( (macromolecule catabolic process) AnnotationAssertion(Annotation( "GOC:mah") "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.") -AnnotationAssertion( "GO:0043285") -AnnotationAssertion( "GO:0044266") AnnotationAssertion(Annotation( "GOC:mtg_chebi_dec09") "biopolymer catabolic process") AnnotationAssertion( "macromolecule breakdown") AnnotationAssertion( "macromolecule catabolism") @@ -33545,11 +32846,10 @@ EquivalentClasses( ObjectIntersection # Class: (biosynthetic process) -AnnotationAssertion(Annotation( "GOC:curators") Annotation( "ISBN:0198547684") "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.") +AnnotationAssertion(Annotation( "GOC:curators") Annotation( "ISBN:0198547684") "A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.") +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/28932"^^xsd:anyURI) AnnotationAssertion( "jl") AnnotationAssertion( "2012-10-17T15:52:18Z") -AnnotationAssertion( "GO:0044274") -AnnotationAssertion( "GO:0044711") AnnotationAssertion( "formation") AnnotationAssertion( "Wikipedia:Anabolism") AnnotationAssertion( "anabolism") @@ -33572,7 +32872,6 @@ AnnotationAssertion(Annotation( "https://github.com/geneontology/go-ontology/issues/15249"^^xsd:anyURI) AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/25418"^^xsd:anyURI) AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/27189"^^xsd:anyURI) -AnnotationAssertion( "GO:0043284") AnnotationAssertion(Annotation( "GOC:mtg_chebi_dec09") "biopolymer biosynthetic process") AnnotationAssertion( "macromolecule anabolism") AnnotationAssertion( "macromolecule biosynthesis") @@ -33586,7 +32885,6 @@ AnnotationAssertion(rdfs:comment "No AnnotationAssertion(rdfs:label "macromolecule biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) -SubClassOf( ) # Class: (amino acid catabolic process) @@ -33794,8 +33092,6 @@ SubClassOf( (protein secretion) AnnotationAssertion(Annotation( "GOC:ai") "The controlled release of proteins from a cell.") -AnnotationAssertion( "GO:0045166") -AnnotationAssertion( "GO:0045731") AnnotationAssertion( "glycoprotein secretion") AnnotationAssertion( "protein secretion during cell fate commitment") AnnotationAssertion( "protein secretion resulting in cell fate commitment") @@ -33811,7 +33107,6 @@ SubClassOf( "GOC:jl") Annotation( "ISBN:0198506732") "The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.") AnnotationAssertion( "jl") AnnotationAssertion( "2009-07-15T11:55:44Z") -AnnotationAssertion( "GO:0044106") AnnotationAssertion( "amine metabolism") AnnotationAssertion( "cellular amine metabolic process") AnnotationAssertion( "biological_process") @@ -34090,7 +33385,6 @@ SubClassOf( (response to wounding) AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.") -AnnotationAssertion( "GO:0002245") AnnotationAssertion( "physiological response to wounding") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0009611") @@ -34111,8 +33405,6 @@ SubClassOf( (response to bacterium) AnnotationAssertion(Annotation( "GOC:hb") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.") -AnnotationAssertion( "GO:0009618") -AnnotationAssertion( "GO:0009680") AnnotationAssertion( "response to bacteria") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0009617") @@ -34123,7 +33415,6 @@ SubClassOf( (response to fungus) AnnotationAssertion(Annotation( "GOC:hb") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus.") -AnnotationAssertion( "GO:0009621") AnnotationAssertion( "response to fungi") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0009620") @@ -34286,7 +33577,6 @@ EquivalentClasses( ObjectIntersection # Class: (embryo development) AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "GOC:isa_complete") Annotation( "GOC:mtg_sensu") "The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.") -AnnotationAssertion( "GO:0009795") AnnotationAssertion( "embryogenesis and morphogenesis") AnnotationAssertion( "Wikipedia:Embryogenesis") AnnotationAssertion( "embryogenesis") @@ -34455,7 +33745,6 @@ SubClassOf( (negative regulation of metabolic process) AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.") -AnnotationAssertion( "GO:0044252") AnnotationAssertion( "down regulation of metabolic process") AnnotationAssertion( "down-regulation of metabolic process") AnnotationAssertion( "downregulation of metabolic process") @@ -34472,7 +33761,6 @@ EquivalentClasses( ObjectIntersection # Class: (positive regulation of metabolic process) AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.") -AnnotationAssertion( "GO:0044253") AnnotationAssertion( "positive regulation of metabolism") AnnotationAssertion( "up regulation of metabolic process") AnnotationAssertion( "up-regulation of metabolic process") @@ -34538,7 +33826,6 @@ SubClassOf( (epidermal cell differentiation) AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:go_curators") Annotation( "GOC:mtg_sensu") Annotation( "GOC:sdb_2009") Annotation( "GOC:tb") "The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis.") -AnnotationAssertion( "GO:0043355") AnnotationAssertion( "biological_process") AnnotationAssertion(Annotation( "GOC:kmv") Annotation( "GOC:rk") "hypodermal cell differentiation") AnnotationAssertion( "GO:0009913") @@ -34579,7 +33866,6 @@ SubClassOf( (regulation of signal transduction) AnnotationAssertion(Annotation( "GOC:sm") "Any process that modulates the frequency, rate or extent of signal transduction.") -AnnotationAssertion( "GO:0035466") AnnotationAssertion( "biological_process") AnnotationAssertion( "regulation of signaling pathway") AnnotationAssertion(Annotation( "GOC:mah") "regulation of signalling pathway") @@ -34593,7 +33879,6 @@ SubClassOf( (positive regulation of signal transduction) AnnotationAssertion(Annotation( "GOC:sm") "Any process that activates or increases the frequency, rate or extent of signal transduction.") -AnnotationAssertion( "GO:0035468") AnnotationAssertion( "up regulation of signal transduction") AnnotationAssertion( "up-regulation of signal transduction") AnnotationAssertion( "upregulation of signal transduction") @@ -34613,7 +33898,6 @@ SubClassOf( (negative regulation of signal transduction) AnnotationAssertion(Annotation( "GOC:sm") "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction.") -AnnotationAssertion( "GO:0035467") AnnotationAssertion( "down regulation of signal transduction") AnnotationAssertion( "down-regulation of signal transduction") AnnotationAssertion( "downregulation of signal transduction") @@ -34632,7 +33916,6 @@ SubClassOf( (proton motive force dependent protein transmembrane transporter activity) AnnotationAssertion(Annotation( "PMID:11526245") Annotation( "PMID:25494301") "Catalysis of the transfer of proteins from one side of a membrane to the other. Transportation is dependent on pH gradient across the membrane.") -AnnotationAssertion( "GO:0015557") AnnotationAssertion( "arginine targeting transmembrane transporter activity") AnnotationAssertion( "delta-pH-dependent protein transporter activity") AnnotationAssertion( "pH-dependent protein transporter activity") @@ -34647,9 +33930,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "GOC:isa_complete") "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.") AnnotationAssertion( "jl") AnnotationAssertion( "2012-12-11T16:56:55Z") -AnnotationAssertion( "GO:0008151") -AnnotationAssertion( "GO:0044763") -AnnotationAssertion( "GO:0050875") AnnotationAssertion( "cell physiology") AnnotationAssertion( "cellular physiological process") AnnotationAssertion( "cell growth and/or maintenance") @@ -34689,8 +33969,6 @@ SubClassOf( ObjectSomeValuesFrom( (glial cell differentiation) AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "GOC:mtg_sensu") "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell.") -AnnotationAssertion( "GO:0007404") -AnnotationAssertion( "GO:0043360") AnnotationAssertion( "glia cell differentiation") AnnotationAssertion( "neuroglia differentiation") AnnotationAssertion( "biological_process") @@ -34769,7 +34047,6 @@ EquivalentClasses( ObjectIntersection # Class: (formation of animal organ boundary) AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:isa_complete") Annotation( "PMID:9611175") "The regionalization process that specifies animal organ primordium boundaries resulting in a restriction of organogenesis to a limited spatial domain and keeping the organ separate from surrounding tissues.") -AnnotationAssertion( "GO:0048862") AnnotationAssertion( "organ boundary specification") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0010160") @@ -34815,7 +34092,6 @@ SubClassOf( "GOC:tb") "The infolding of a membrane.") AnnotationAssertion( "jl") AnnotationAssertion( "2013-12-02T13:58:34Z") -AnnotationAssertion( "GO:1902534") AnnotationAssertion( "biological_process") AnnotationAssertion( "single-organism membrane invagination") AnnotationAssertion( "GO:0010324") @@ -34950,7 +34226,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:dhl") "The movement of substances between cells.") AnnotationAssertion( "jl") AnnotationAssertion( "2013-12-19T13:24:56Z") -AnnotationAssertion( "GO:1902585") AnnotationAssertion( "biological_process") AnnotationAssertion(Annotation( "GOC:TermGenie") "single organism intercellular transport") AnnotationAssertion( "single-organism intercellular transport") @@ -35050,14 +34325,14 @@ AnnotationAssertion(rdfs:label "regu EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) -# Class: (regulation of cellular ketone metabolic process) +# Class: (regulation of ketone metabolic process) AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.") +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/28908"^^xsd:anyURI) AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0010565") -AnnotationAssertion(rdfs:label "regulation of cellular ketone metabolic process") +AnnotationAssertion(rdfs:label "regulation of ketone metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) # Class: (regulation of ketone biosynthetic process) @@ -35066,8 +34341,8 @@ AnnotationAssertion( "GO:0010566") AnnotationAssertion(rdfs:label "regulation of ketone biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) SubClassOf( ) -SubClassOf( ) # Class: (regulation of ketone catabolic process) @@ -36173,7 +35448,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:lr") Annotation( "GOC:mtg_apoptosis") "A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/24835"^^xsd:anyURI) -AnnotationAssertion( "GO:0016244") AnnotationAssertion( "regulated cell death") AnnotationAssertion( "Wikipedia:Programmed_cell_death") AnnotationAssertion( "caspase-independent cell death") @@ -36376,7 +35650,6 @@ SubClassOf( ObjectSomeValuesFrom( (primary neural tube formation) AnnotationAssertion(Annotation( "GOC:ef") Annotation( "ISBN:0878932585") Annotation( "PMID:15327780") "The formation of the neural tube from an epithelial cell sheet (the neuroepithelium or neural plate). In primary neurulation, the cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate, and pinch off from the surface to form a hollow epithelial tube. Primary neurulation is the typical mechanism of formation of the anterior neural tube.") -AnnotationAssertion( "GO:0014024") AnnotationAssertion(Annotation( "GOC:dph") "primary neural tube morphogenesis") AnnotationAssertion( "primary neurulation") AnnotationAssertion( "biological_process") @@ -37334,7 +36607,6 @@ EquivalentClasses( ObjectIntersection # Class: (protein transport) AnnotationAssertion(Annotation( "GOC:ai") "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") -AnnotationAssertion( "GO:0015831") AnnotationAssertion( "enzyme transport") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0015031") @@ -37364,9 +36636,10 @@ AnnotationAssertion(Annotation( "Reactome:R-HSA-1222516") AnnotationAssertion(Annotation(rdfs:label "Enzyme-bound ATP is released") "Reactome:R-HSA-164834") AnnotationAssertion(Annotation(rdfs:label "Virion-associated M2 protein mediated ion infusion") "Reactome:R-HSA-168313") -AnnotationAssertion(Annotation(rdfs:label "Protons are translocated from the intermembrane space to the matrix") "Reactome:R-HSA-170026") +AnnotationAssertion(Annotation(rdfs:label "UCP1 imports a proton") "Reactome:R-HSA-170026") AnnotationAssertion(Annotation(rdfs:label "Endosome acidification") "Reactome:R-HSA-74723") AnnotationAssertion(Annotation(rdfs:label "Acidification of Tf:TfR1 containing endosome") "Reactome:R-HSA-917841") +AnnotationAssertion(Annotation(rdfs:label "AAC1 imports a proton") "Reactome:R-HSA-9864415") AnnotationAssertion( "hydrogen ion transmembrane transporter activity") AnnotationAssertion( "proton transporter activity") AnnotationAssertion( "molecular_function") @@ -37378,9 +36651,7 @@ SubClassOf(Annotation( "GO_ # Class: (potassium ion transmembrane transporter activity) AnnotationAssertion(Annotation( "GOC:ai") "Enables the transfer of potassium ions (K+) from one side of a membrane to the other.") -AnnotationAssertion( "GO:0015388") -AnnotationAssertion( "GO:0022817") -AnnotationAssertion( "RHEA:29463") +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/27521"^^xsd:anyURI) AnnotationAssertion( "potassium transporter activity") AnnotationAssertion( "molecular_function") AnnotationAssertion( "potassium uptake permease activity") @@ -37389,41 +36660,37 @@ AnnotationAssertion( "potassium ion transmembrane transporter activity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf(Annotation( "GO_REF:0000090") ObjectSomeValuesFrom( )) -SubClassOf( ObjectSomeValuesFrom( )) # Class: (sodium ion transmembrane transporter activity) -AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:ai") Annotation( "RHEA:34963") "Enables the transfer of sodium ions (Na+) from one side of a membrane to the other.") +AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:ai") "Enables the transfer of sodium ions (Na+) from one side of a membrane to the other.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/24076"^^xsd:anyURI) -AnnotationAssertion( "GO:0022816") -AnnotationAssertion( "RHEA:34963") +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/27521"^^xsd:anyURI) AnnotationAssertion( "sodium transporter activity") AnnotationAssertion( "molecular_function") AnnotationAssertion( "GO:0015081") AnnotationAssertion(rdfs:label "sodium ion transmembrane transporter activity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) -SubClassOf( ObjectSomeValuesFrom( )) # Class: (calcium ion transmembrane transporter activity) -AnnotationAssertion(Annotation( "GOC:dgf") Annotation( "RHEA:29671") "Enables the transfer of calcium (Ca) ions from one side of a membrane to the other.") +AnnotationAssertion(Annotation( "GOC:dgf") "Enables the transfer of calcium (Ca) ions from one side of a membrane to the other.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/26941"^^xsd:anyURI) +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/27521"^^xsd:anyURI) AnnotationAssertion( "MetaCyc:TRANS-RXN-144") -AnnotationAssertion( "RHEA:29671") AnnotationAssertion(Annotation(rdfs:label "CatSper Channel Mediated Calcium Transport") "Reactome:R-HSA-2534359") AnnotationAssertion( "molecular_function") AnnotationAssertion( "GO:0015085") AnnotationAssertion(rdfs:label "calcium ion transmembrane transporter activity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) -SubClassOf( ObjectSomeValuesFrom( )) # Class: (bicarbonate transmembrane transporter activity) AnnotationAssertion(Annotation( "GOC:ai") "Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/26780"^^xsd:anyURI) -AnnotationAssertion( "RHEA:28695") +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/27521"^^xsd:anyURI) AnnotationAssertion(Annotation(rdfs:label "BESTs transport cytosolic HCO3- to extracellular region") "Reactome:R-HSA-2752067") AnnotationAssertion( "hydrogencarbonate transmembrane transporter activity") AnnotationAssertion( "molecular_function") @@ -37431,7 +36698,6 @@ AnnotationAssertion( "bicarbonate transmembrane transporter activity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) -SubClassOf( ObjectSomeValuesFrom( )) # Class: (bile acid transmembrane transporter activity) @@ -37451,7 +36717,6 @@ SubClassOf( ObjectSomeValuesFrom( (carbohydrate transmembrane transporter activity) AnnotationAssertion(Annotation( "GOC:jl") Annotation( "GOC:mtg_transport") Annotation( "ISBN:0815340729") "Enables the transfer of carbohydrate from one side of a membrane to the other.") -AnnotationAssertion( "GO:1901476") AnnotationAssertion( "sugar transporter") AnnotationAssertion( "molecular_function") AnnotationAssertion( "carbohydrate transporter activity") @@ -37483,7 +36748,6 @@ SubClassOf( ObjectSomeValuesFrom( (amino acid transmembrane transporter activity) AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:mtg_transport") Annotation( "ISBN:0815340729") "Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group.") -AnnotationAssertion( "GO:0015359") AnnotationAssertion( "amino acid transporter activity") AnnotationAssertion(Annotation(rdfs:label "glutamate uptake by astrocytes") "Reactome:R-HSA-210439") AnnotationAssertion(Annotation(rdfs:label "L-Glutamine transport into neurons") "Reactome:R-HSA-212642") @@ -37545,7 +36809,7 @@ SubClassOf(Annotation( "GO_ AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:mtg_transport") Annotation( "ISBN:0815340729") "Enables the transfer of acidic amino acids from one side of a membrane to the other. Acidic amino acids have side chains with a negative charge at pH 7.3.") AnnotationAssertion( "acidic amino acid transporter activity") -AnnotationAssertion(Annotation(rdfs:label "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp") "Reactome:R-HSA-372448") +AnnotationAssertion(Annotation(rdfs:label "SLC25A12,13 exchange L-Glu and L-Asp") "Reactome:R-HSA-372448") AnnotationAssertion( "molecular_function") AnnotationAssertion( "GO:0015172") AnnotationAssertion(rdfs:label "acidic amino acid transmembrane transporter activity") @@ -37555,8 +36819,6 @@ SubClassOf( ObjectSomeValuesFrom( (basic amino acid transmembrane transporter activity) AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:mtg_transport") Annotation( "ISBN:0815340729") "Enables the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have side chains with a positive charge at pH 7.3.") -AnnotationAssertion( "GO:0005286") -AnnotationAssertion( "GO:0015326") AnnotationAssertion( "basic amino acid transporter activity") AnnotationAssertion(Annotation(rdfs:label "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol") "Reactome:R-HSA-8932851") AnnotationAssertion(Annotation(rdfs:label "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix") "Reactome:R-HSA-8959781") @@ -37618,8 +36880,9 @@ SubClassOf( ObjectSomeValuesFrom( "GOC:mtg_transport") Annotation( "ISBN:0815340729") "Enables the energy-independent facilitated diffusion of water through a transmembrane aqueous pore or channel.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/26941"^^xsd:anyURI) +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/27521"^^xsd:anyURI) AnnotationAssertion( "MetaCyc:TRANS-RXN-145") -AnnotationAssertion( "RHEA:29667") +AnnotationAssertion(Annotation( "skos:broadMatch") "RHEA:29667") AnnotationAssertion(Annotation(rdfs:label "Aquaporin-1 passively transports water into cell") "Reactome:R-HSA-432010") AnnotationAssertion(Annotation(rdfs:label "Aquaporin-1 passively transports water out of cell") "Reactome:R-HSA-432054") AnnotationAssertion(Annotation(rdfs:label "p-S256-Aquaporin-2 passively transports water into cell") "Reactome:R-HSA-432065") @@ -37653,9 +36916,6 @@ SubClassOf( ObjectSomeValuesFrom( (channel activity) AnnotationAssertion(Annotation( "GOC:mtg_transport") Annotation( "ISBN:0815340729") "Enables the energy-independent facilitated diffusion of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.") -AnnotationAssertion( "GO:0015249") -AnnotationAssertion( "GO:0015268") -AnnotationAssertion( "GO:0022838") AnnotationAssertion( "pore activity") AnnotationAssertion(Annotation(rdfs:label "H2O2 diffuses from the mitochondrial matrix to the cytosol") "Reactome:R-HSA-3779381") AnnotationAssertion(Annotation(rdfs:label "PXMP2 trimer transports glycolate from cytosol to peroxisomal matrix") "Reactome:R-HSA-8953430") @@ -37673,7 +36933,7 @@ SubClassOf( (calcium-activated potassium channel activity) -AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_transport") "Enables the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient.") +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_transport") "Enables the transmembrane transfer of a potassium cation by a channel that opens when a calcium cation has been bound by the channel complex or one of its constituent parts.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/24605"^^xsd:anyURI) AnnotationAssertion(Annotation(rdfs:label "KCNN2 transports K+ from the cytosol to the extracellular region") "Reactome:R-HSA-9663752") AnnotationAssertion(Annotation(rdfs:label "KCNMA1:KCNMB1 transports potassium ions from the cytosol to the extracellular region") "Reactome:R-HSA-9667809") @@ -37723,10 +36983,6 @@ EquivalentClasses( ObjectIntersection # Class: (secondary active transmembrane transporter activity) AnnotationAssertion(Annotation( "GOC:mtg_transport") Annotation( "ISBN:0198506732") Annotation( "ISBN:0815340729") Annotation( "PMID:10839820") "Enables the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy, not direct ATP coupling. Secondary active transporters include symporters and antiporters.") -AnnotationAssertion( "GO:0015290") -AnnotationAssertion( "GO:0015353") -AnnotationAssertion( "GO:0015404") -AnnotationAssertion( "GO:0015570") AnnotationAssertion( "active transporter") AnnotationAssertion( "TC:2.A") AnnotationAssertion( "coupled carrier") @@ -37782,6 +37038,19 @@ AnnotationAssertion( "tubulin binding") SubClassOf( ) +# Class: (short-chain fatty acid transmembrane transporter activity) + +AnnotationAssertion(Annotation( "GOC:mah") "Enables the transfer of short-chain fatty acids from one side of a membrane to the other. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons.") +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/26445"^^xsd:anyURI) +AnnotationAssertion( "molecular_function") +AnnotationAssertion( "short-chain fatty acid transporter activity") +AnnotationAssertion( "short-chain fatty acid uptake transporter activity") +AnnotationAssertion( "GO:0015636") +AnnotationAssertion(rdfs:comment "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).") +AnnotationAssertion(rdfs:label "short-chain fatty acid transmembrane transporter activity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (gas transport) AnnotationAssertion(Annotation( "GOC:ai") "The directed movement of substances that are gaseous in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") @@ -37880,7 +37149,6 @@ EquivalentClasses( ObjectIntersection # Class: (L-glutamate transmembrane transport) AnnotationAssertion(Annotation( "PMID:21307582") "The directed movement of L-glutamate across a membrane by means of some agent such as a transporter or a pore.") -AnnotationAssertion( "GO:0089711") AnnotationAssertion( "L-glutamate transport") AnnotationAssertion( "biological_process") AnnotationAssertion( "mitochondrial aspartate/glutamate transport") @@ -37980,6 +37248,29 @@ AnnotationAssertion(rdfs:label "nore EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (short-chain fatty acid transport) + +AnnotationAssertion(Annotation( "GOC:ai") "The directed movement of short-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons.") +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/26445"^^xsd:anyURI) +AnnotationAssertion( "biological_process") +AnnotationAssertion( "GO:0015912") +AnnotationAssertion(rdfs:comment "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).") +AnnotationAssertion(rdfs:label "short-chain fatty acid transport") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (short-chain fatty acid transmembrane transport) + +AnnotationAssertion(Annotation( "GOC:ai") "The directed movement of short-chain fatty acids into a cell or organelle. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons.") +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/24587"^^xsd:anyURI) +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/26445"^^xsd:anyURI) +AnnotationAssertion( "short-chain fatty acid uptake") +AnnotationAssertion( "biological_process") +AnnotationAssertion( "short-chain fatty acid import") +AnnotationAssertion( "GO:0015913") +AnnotationAssertion(rdfs:comment "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).") +AnnotationAssertion(rdfs:label "short-chain fatty acid transmembrane transport") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (nucleobase-containing compound transport) AnnotationAssertion(Annotation( "GOC:ai") "The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") @@ -38018,7 +37309,7 @@ AnnotationAssertion( ) AnnotationAssertion( ) AnnotationAssertion(rdfs:label "photosynthesis") -SubClassOf( ) +SubClassOf( ) SubClassOf( ObjectComplementOf(ObjectSomeValuesFrom( ))) SubClassOf( ObjectComplementOf(ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( ObjectComplementOf())) @@ -38039,9 +37330,6 @@ SubClassOf( "GOC:dos") Annotation( "GOC:mah") Annotation( "ISBN:0815316194") "A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.") AnnotationAssertion( "2014-03-06T11:37:54Z") -AnnotationAssertion( "GO:0016021") -AnnotationAssertion( "GO:0098589") -AnnotationAssertion( "GO:0098805") AnnotationAssertion( "Wikipedia:Biological_membrane") AnnotationAssertion( "Wikipedia:Transmembrane_protein") AnnotationAssertion( "integral component of membrane") @@ -38066,8 +37354,6 @@ DisjointClasses( (lipid catabolic process) AnnotationAssertion(Annotation( "GOC:go_curators") "The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.") -AnnotationAssertion( "GO:0006724") -AnnotationAssertion( "GO:0044240") AnnotationAssertion( "Wikipedia:Lipid_catabolism") AnnotationAssertion( "lipid breakdown") AnnotationAssertion( "lipid catabolism") @@ -38083,8 +37369,6 @@ EquivalentClasses( ObjectIntersection # Class: (cellular component organization) AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:jl") Annotation( "GOC:mah") "A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component.") -AnnotationAssertion( "GO:0044235") -AnnotationAssertion( "GO:0071842") AnnotationAssertion( "cell organisation") AnnotationAssertion(Annotation( "GOC:mah") "cellular component organisation at cellular level") AnnotationAssertion(Annotation( "GOC:mah") "cellular component organisation in other organism") @@ -38119,7 +37403,6 @@ SubClassOf( (cell growth) AnnotationAssertion(Annotation( "GOC:ai") "The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.") -AnnotationAssertion( "GO:0048591") AnnotationAssertion( "cellular growth") AnnotationAssertion( "growth of cell") AnnotationAssertion( "biological_process") @@ -38154,7 +37437,6 @@ SubClassOf( (carbohydrate biosynthetic process) AnnotationAssertion(Annotation( "ISBN:0198506732") "The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.") -AnnotationAssertion( "GO:0006093") AnnotationAssertion( "anabolic carbohydrate metabolic process") AnnotationAssertion( "anabolic carbohydrate metabolism") AnnotationAssertion( "carbohydrate anabolism") @@ -38171,9 +37453,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "ISBN:0198506732") "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.") AnnotationAssertion( "jl") AnnotationAssertion( "2012-10-23T16:34:39Z") -AnnotationAssertion( "GO:0006095") -AnnotationAssertion( "GO:0044276") -AnnotationAssertion( "GO:0044724") AnnotationAssertion( "carbohydrate breakdown") AnnotationAssertion( "carbohydrate catabolism") AnnotationAssertion( "carbohydrate degradation") @@ -38198,7 +37477,6 @@ AnnotationAssertion( "organic acid biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) -SubClassOf( ) SubClassOf( ) # Class: (organic acid catabolic process) @@ -38264,7 +37542,6 @@ SubClassOf( ObjectSomeValuesFrom( "GOC:ai") Annotation( "GOC:mah") Annotation( "ISBN:08789310662000") "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/25421"^^xsd:anyURI) -AnnotationAssertion( "GO:0006899") AnnotationAssertion( "vesicle transport") AnnotationAssertion(Annotation( "GOC:mah") "vesicular transport") AnnotationAssertion( "nonselective vesicle transport") @@ -38345,7 +37622,6 @@ EquivalentClasses( ObjectIntersection # Class: (oocyte microtubule cytoskeleton organization) AnnotationAssertion(Annotation( "GOC:mtg_sensu") Annotation( "PMID:11231123") "Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster.") -AnnotationAssertion( "GO:0048130") AnnotationAssertion( "oocyte microtubule cytoskeleton organisation") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0016325") @@ -38449,7 +37725,6 @@ EquivalentClasses( ObjectIntersection # Class: (protein processing) AnnotationAssertion(Annotation( "GOC:curators") Annotation( "GOC:jl") Annotation( "GOC:jsg") "Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.") -AnnotationAssertion( "GO:0051605") AnnotationAssertion(Annotation( "GOC:bf") "protein maturation by peptide bond cleavage") AnnotationAssertion(Annotation( "GOC:mah") "protein maturation by peptide bond hydrolysis") AnnotationAssertion( "biological_process") @@ -38653,8 +37928,6 @@ AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/20498"^^xsd:anyURI) AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/21612"^^xsd:anyURI) AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/22371"^^xsd:anyURI) -AnnotationAssertion( "GO:0004002") -AnnotationAssertion( "GO:0042623") AnnotationAssertion( "RHEA:13065") AnnotationAssertion(Annotation(rdfs:label "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B)") "Reactome:R-HSA-159101") AnnotationAssertion(Annotation(rdfs:label "ATP hydrolysis by HSP70") "Reactome:R-HSA-3371422") @@ -38697,7 +37970,7 @@ SubClassOf( ObjectSomeValuesFrom( (G protein-coupled acetylcholine receptor activity) AnnotationAssertion(Annotation( "GOC:bf") Annotation( "GOC:fj") Annotation( "GOC:mah") "Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.") -AnnotationAssertion( "GO:0004981") +AnnotationAssertion(Annotation(rdfs:label "Acetylcholine binds Muscarinic Acetylcholine Receptor M3") "Reactome:R-HSA-400012") AnnotationAssertion( "G protein coupled acetylcholine receptor activity") AnnotationAssertion( "G-protein coupled acetylcholine receptor activity") AnnotationAssertion(Annotation( "GOC:bf") "acetylcholine receptor activity, G-protein coupled") @@ -38734,8 +38007,6 @@ AnnotationAssertion(Annotation( ) AnnotationAssertion( ) AnnotationAssertion( ) -AnnotationAssertion( "GO:0035257") -AnnotationAssertion( "GO:0035258") AnnotationAssertion( "steroid hormone receptor binding") AnnotationAssertion( "ligand-dependent nuclear receptor binding") AnnotationAssertion( "nuclear hormone receptor binding") @@ -38764,24 +38035,6 @@ AnnotationAssertion(rdfs:label "pept EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) -# Class: (transcription repressor complex) - -AnnotationAssertion(Annotation( "GOC:mah") "A protein complex that possesses activity that prevents or downregulates transcription.") -AnnotationAssertion( "tb") -AnnotationAssertion( "2014-05-09T13:23:51Z") -AnnotationAssertion( "GO:0090568") -AnnotationAssertion( "GO:0090569") -AnnotationAssertion(Annotation( "GOC:bhm") "transcription factor inhibitor complex") -AnnotationAssertion( "transcriptional repressor complex") -AnnotationAssertion( "cellular_component") -AnnotationAssertion( "cytoplasmic transcriptional repressor complex") -AnnotationAssertion( "nuclear transcriptional repressor complex") -AnnotationAssertion( "GO:0017053") -AnnotationAssertion( ) -AnnotationAssertion(rdfs:label "transcription repressor complex") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) - # Class: (ribonucleoside triphosphate phosphatase activity) AnnotationAssertion(Annotation( "RHEA:23680") "Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate.") @@ -38852,7 +38105,6 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (negative regulation of translation) AnnotationAssertion(Annotation( "GOC:isa_complete") "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.") -AnnotationAssertion( "GO:0016478") AnnotationAssertion( "down regulation of protein biosynthetic process") AnnotationAssertion( "down-regulation of protein biosynthetic process") AnnotationAssertion( "downregulation of protein biosynthetic process") @@ -38948,9 +38200,6 @@ AnnotationAssertion(Annotation( "https://github.com/geneontology/go-ontology/issues/23491"^^xsd:anyURI) AnnotationAssertion( "jl") AnnotationAssertion( "2012-09-19T16:01:37Z") -AnnotationAssertion( "GO:0033057") -AnnotationAssertion( "GO:0044704") -AnnotationAssertion( "GO:0044705") AnnotationAssertion( "reproductive behavior in a multicellular organism") AnnotationAssertion( "reproductive behaviour") AnnotationAssertion( "multi-organism reproductive behavior") @@ -39033,7 +38282,6 @@ SubClassOf( ObjectSomeValuesFrom( (regulation of metabolic process) AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.") -AnnotationAssertion( "GO:0044246") AnnotationAssertion( "regulation of metabolism") AnnotationAssertion( "regulation of multicellular organismal metabolic process") AnnotationAssertion(Annotation( "GOC:tb") "regulation of organismal metabolic process") @@ -39145,9 +38393,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:ma") "The chemical reactions and pathways involving a protein. Includes protein modification.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/23112"^^xsd:anyURI) AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/27189"^^xsd:anyURI) -AnnotationAssertion( "GO:0006411") -AnnotationAssertion( "GO:0044267") -AnnotationAssertion( "GO:0044268") AnnotationAssertion( "Wikipedia:Protein_metabolism") AnnotationAssertion( "cellular protein metabolic process") AnnotationAssertion( "cellular protein metabolism") @@ -39181,6 +38426,20 @@ AnnotationAssertion( "catechol-containing compound catabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (short-chain fatty acid catabolic process) + +AnnotationAssertion(Annotation( "ISBN:0198506732") "The chemical reactions and pathways resulting in the breakdown of a short-chain fatty acid. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons.") +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/26445"^^xsd:anyURI) +AnnotationAssertion( "MetaCyc:ACETOACETATE-DEG-PWY") +AnnotationAssertion( "short-chain fatty acid breakdown") +AnnotationAssertion( "short-chain fatty acid catabolism") +AnnotationAssertion( "short-chain fatty acid degradation") +AnnotationAssertion( "biological_process") +AnnotationAssertion( "GO:0019626") +AnnotationAssertion(rdfs:comment "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).") +AnnotationAssertion(rdfs:label "short-chain fatty acid catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (calcium-mediated signaling) AnnotationAssertion(Annotation( "GOC:signaling") "Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.") @@ -39227,8 +38486,6 @@ DisjointClasses( (antimicrobial humoral response) AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "GOC:mtg_sensu") "An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus.") -AnnotationAssertion( "GO:0006960") -AnnotationAssertion( "GO:0019735") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0019730") AnnotationAssertion(rdfs:label "antimicrobial humoral response") @@ -39277,7 +38534,6 @@ SubClassOf( (B cell receptor complex) AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781735149") "An immunoglobulin complex that is present in the plasma membrane of B cells and that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins.") -AnnotationAssertion( "GO:0042570") AnnotationAssertion( "B lymphocyte receptor complex") AnnotationAssertion( "B-cell receptor complex") AnnotationAssertion( "B-lymphocyte receptor complex") @@ -39336,7 +38592,6 @@ SubClassOf( (antigen processing and presentation) AnnotationAssertion(Annotation( "GOC:add") Annotation( "GO_REF:0000022") Annotation( "ISBN:0781735149") Annotation( "PMID:15771591") Annotation( "PMID:15928678") "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.") -AnnotationAssertion( "GO:0030333") AnnotationAssertion( "Wikipedia:Antigen_presentation") AnnotationAssertion( "antigen presentation") AnnotationAssertion( "antigen processing") @@ -39369,7 +38624,6 @@ SubClassOf( "GOC:ai") Annotation( "GOC:bf") Annotation( "ISBN:0198599471") "Binding to a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.") AnnotationAssertion( ) -AnnotationAssertion( "GO:0019965") AnnotationAssertion( "IL binding") AnnotationAssertion( "interleukin binding") AnnotationAssertion( "molecular_function") @@ -41797,7 +41051,6 @@ SubClassOf( "GOC:isa_complete") "A cellular process that results in the breakdown of a cellular component.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/27189"^^xsd:anyURI) -AnnotationAssertion( "GO:0071845") AnnotationAssertion( "cell structure disassembly") AnnotationAssertion( "cellular component disassembly at cellular level") AnnotationAssertion( "biological_process") @@ -41837,7 +41090,6 @@ AnnotationAssertion(Annotation( "https://github.com/geneontology/go-ontology/issues/27054"^^xsd:anyURI) AnnotationAssertion( "jl") AnnotationAssertion( "2012-09-19T15:56:06Z") -AnnotationAssertion( "GO:0044702") AnnotationAssertion( "Wikipedia:Reproduction") AnnotationAssertion( "biological_process") AnnotationAssertion( "single organism reproductive process") @@ -41913,7 +41165,6 @@ SubClassOf( ObjectSomeValuesFrom( (cellular component assembly) AnnotationAssertion(Annotation( "GOC:isa_complete") "The aggregation, arrangement and bonding together of a cellular component.") -AnnotationAssertion( "GO:0071844") AnnotationAssertion( "cell structure assembly") AnnotationAssertion( "cellular component assembly at cellular level") AnnotationAssertion( "biological_process") @@ -41974,9 +41225,6 @@ SubClassOf( ObjectSomeValuesFrom( (cytosolic ribosome) AnnotationAssertion(Annotation( "GOC:mtg_sensu") "A ribosome located in the cytosol.") -AnnotationAssertion( "GO:0005830") -AnnotationAssertion( "GO:0009281") -AnnotationAssertion( "GO:0030871") AnnotationAssertion( "70S ribosome") AnnotationAssertion( "80S ribosome") AnnotationAssertion( "cellular_component") @@ -41989,9 +41237,7 @@ SubClassOf( ObjectAllValuesFrom( (passive transmembrane transporter activity) AnnotationAssertion(Annotation( "GOC:mtg_transport") Annotation( "ISBN:0815340729") "Enables the transfer of a single solute from one side of a membrane to the other by a mechanism involving conformational change, either by facilitated diffusion or in a membrane potential dependent process if the solute is charged.") -AnnotationAssertion( "GO:0022814") AnnotationAssertion( "porters") -AnnotationAssertion(Annotation(rdfs:label "Passive I- efflux mediated by SMCT1") "Reactome:R-HSA-429767") AnnotationAssertion( "Wikipedia:Facilitated_diffusion") AnnotationAssertion( "uniporter activity z") AnnotationAssertion( "molecular_function") @@ -42063,8 +41309,6 @@ EquivalentClasses( ObjectIntersection # Class: (acetylcholine-gated monoatomic cation-selective channel activity) AnnotationAssertion(Annotation( "GOC:mah") Annotation( "PMID:2466967") "Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine.") -AnnotationAssertion( "GO:0004889") -AnnotationAssertion( "GO:0016904") AnnotationAssertion( "acetylcholine-gated cation-selective channel activity") AnnotationAssertion( "acetylcholine-activated cation-selective channel activity") AnnotationAssertion( "acetylcholine-gated cation channel activity") @@ -42091,7 +41335,6 @@ SubClassOf( (serotonin-gated monoatomic cation channel activity) AnnotationAssertion(Annotation( "GOC:mtg_transport") Annotation( "PMID:12867984") "Enables the transmembrane transfer of a cation by a channel that opens when serotonin has been bound by the channel complex or one of its constituent parts.") -AnnotationAssertion( "GO:0005232") AnnotationAssertion( "serotonin-gated cation-selective channel activity") AnnotationAssertion(Annotation(rdfs:label "HTR3A pentamer:5HT transports Na+,K+,Ca2+") "Reactome:R-HSA-9648983") AnnotationAssertion(Annotation(rdfs:label "HTR3 pentamers:5HT transport Na+,K+,Ca2+") "Reactome:R-HSA-975311") @@ -42121,11 +41364,6 @@ EquivalentClasses( ObjectIntersection # Class: (transmembrane transporter activity) AnnotationAssertion(Annotation( "GOC:jid") Annotation( "GOC:mtg_transport") Annotation( "ISBN:0815340729") "Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.") -AnnotationAssertion( "GO:0005386") -AnnotationAssertion( "GO:0015563") -AnnotationAssertion( "GO:0015646") -AnnotationAssertion( "GO:0022891") -AnnotationAssertion( "GO:0022892") AnnotationAssertion(Annotation(rdfs:label "Egress of internalized antigen to the cytosol via sec61") "Reactome:R-HSA-1236947") AnnotationAssertion(Annotation(rdfs:label "SLC2A9 transports Fru, Glc, urate") "Reactome:R-HSA-429036") AnnotationAssertion(Annotation(rdfs:label "MATEs mediate extrusion of xenobiotics") "Reactome:R-HSA-434650") @@ -42218,8 +41456,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:mtg_signal") Annotation( "GOC:mtg_signaling_feb11") Annotation( "GOC:signaling") "The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered.") AnnotationAssertion( "jl") AnnotationAssertion( "2010-02-16T09:30:50Z") -AnnotationAssertion( "GO:0023046") -AnnotationAssertion( "GO:0044700") AnnotationAssertion( "biological signaling") AnnotationAssertion( "signaling process") AnnotationAssertion( "signalling") @@ -42294,7 +41530,6 @@ EquivalentClasses( ObjectIntersection # Class: (intracellular potassium ion homeostasis) AnnotationAssertion(Annotation( "GOC:mah") "A homeostatic process involved in the maintenance of a steady state level of potassium ions within a cell.") -AnnotationAssertion( "GO:0017079") AnnotationAssertion( "cellular potassium ion homeostasis") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0030007") @@ -42306,8 +41541,6 @@ SubClassOf( (establishment of cell polarity) AnnotationAssertion(Annotation( "GOC:mah") "The specification and formation of anisotropic intracellular organization or cell growth patterns.") -AnnotationAssertion( "GO:0000283") -AnnotationAssertion( "GO:0030468") AnnotationAssertion( "cell polarization") AnnotationAssertion( "bud site selection/establishment of cell polarity") AnnotationAssertion( "biological_process") @@ -42492,7 +41725,6 @@ SubClassOf( ObjectAllValuesFrom( (lymphocyte differentiation) AnnotationAssertion(Annotation( "CL:0000542") Annotation( "GOC:go_curators") "The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.") -AnnotationAssertion( "GO:0046650") AnnotationAssertion( "lymphocyte cell differentiation") AnnotationAssertion( "lymphocytic blood cell differentiation") AnnotationAssertion( "biological_process") @@ -42614,8 +41846,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:mah") "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/23112"^^xsd:anyURI) -AnnotationAssertion( "GO:0044254") -AnnotationAssertion( "GO:0044257") AnnotationAssertion( "Wikipedia:Protein_catabolism") AnnotationAssertion( "cellular protein breakdown") AnnotationAssertion( "cellular protein catabolic process") @@ -42685,7 +41915,6 @@ SubClassOf( ObjectSomeValuesFrom( (B cell differentiation) AnnotationAssertion(Annotation( "GOC:mah") Annotation( "GO_REF:0000022") "The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.") -AnnotationAssertion( "GO:0042115") AnnotationAssertion( "B lymphocyte differentiation") AnnotationAssertion( "B-cell differentiation") AnnotationAssertion( "B-lymphocyte differentiation") @@ -42957,8 +42186,6 @@ SubClassOf( ObjectSomeValuesFrom( (T cell differentiation) AnnotationAssertion(Annotation( "GOC:jid") Annotation( "GOC:mah") Annotation( "GO_REF:0000022") "The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex.") -AnnotationAssertion( "GO:0042112") -AnnotationAssertion( "GO:0046652") AnnotationAssertion( "T lymphocyte differentiation") AnnotationAssertion( "T-cell differentiation") AnnotationAssertion( "T-lymphocyte differentiation") @@ -43020,7 +42247,6 @@ SubClassOf( (eosinophil differentiation) AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:mah") "The process in which a relatively unspecialized myeloid precursor cell acquires the specializes features of an eosinophil.") -AnnotationAssertion( "GO:0035856") AnnotationAssertion( "eosinophil cell differentiation") AnnotationAssertion( "biological_process") AnnotationAssertion(Annotation( "GOC:bf") "eosinophil cell development") @@ -43089,7 +42315,6 @@ SubClassOf( ObjectSomeValuesFrom( (carbohydrate binding) AnnotationAssertion(Annotation( "GOC:mah") "Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.") -AnnotationAssertion( "GO:0005529") AnnotationAssertion( "sugar binding") AnnotationAssertion( "molecular_function") AnnotationAssertion( "selectin") @@ -43108,7 +42333,6 @@ EquivalentClasses( ObjectIntersection # Class: (polysaccharide binding) AnnotationAssertion(Annotation( "GOC:mah") "Binding to a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.") -AnnotationAssertion( "GO:0002506") AnnotationAssertion( "polysaccharide assembly with MHC class II protein complex") AnnotationAssertion( "molecular_function") AnnotationAssertion( "GO:0030247") @@ -43127,7 +42351,6 @@ SubClassOf( (chromosome condensation) AnnotationAssertion(Annotation( "GOC:mah") Annotation( "ISBN:0815316194") "The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.") -AnnotationAssertion( "GO:0000068") AnnotationAssertion(Annotation( "Wikipedia:DNA_condensation") "DNA condensation") AnnotationAssertion(Annotation( "GOC:bf") "eukaryotic chromosome condensation") AnnotationAssertion(Annotation( "GOC:bf") "nuclear chromosome condensation") @@ -43274,8 +42497,6 @@ SubClassOf( (flagellated sperm motility) AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:cilia") Annotation( "GOC:krc") Annotation( "GO_REF:0000060") Annotation( "PMID:26680031") "The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm.") -AnnotationAssertion( "GO:0097724") -AnnotationAssertion( "GO:1905419") AnnotationAssertion( "sperm motility") AnnotationAssertion( "sperm movement") AnnotationAssertion( "Wikipedia:Sperm_motility") @@ -43460,7 +42681,6 @@ SubClassOf( (ascospore formation) AnnotationAssertion(Annotation( "GOC:di") Annotation( "GOC:mah") Annotation( "GOC:mcc") Annotation( "PMID:16339736") "The process in which cells that are products of meiosis acquire the specialized features of ascospores. Ascospores are generally found in clusters of four or eight spores within a single mother cell, the ascus, and are characteristic of the ascomycete fungi (phylum Ascomycota).") -AnnotationAssertion( "GO:0007151") AnnotationAssertion( "spore formation") AnnotationAssertion( "sporulation") AnnotationAssertion( "ascospore biosynthesis") @@ -43479,7 +42699,6 @@ SubClassOf( ObjectAllValuesFrom( (nuclear migration along microtubule) AnnotationAssertion(Annotation( "GOC:mah") Annotation( "GOC:sgd_curators") "The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins.") -AnnotationAssertion( "GO:0000065") AnnotationAssertion( "nuclear movement, microtubule-mediated") AnnotationAssertion( "nucleus migration") AnnotationAssertion( "microtubule cytoskeleton-dependent nuclear positioning") @@ -43545,29 +42764,6 @@ SubClassOf( ) SubClassOf( ) -# Class: (nuclear receptor-mediated steroid hormone signaling pathway) - -AnnotationAssertion(Annotation( "GOC:mah") Annotation( "GOC:signaling") "A nuclear receptor-mediated signaling pathway initiated by a steroid binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.") -AnnotationAssertion(Annotation( "GOC:bf") "steroid hormone receptor signaling pathway") -AnnotationAssertion(Annotation( "GOC:bf") "steroid hormone receptor signalling pathway") -AnnotationAssertion( "intracellular steroid hormone receptor signaling pathway") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "GO:0030518") -AnnotationAssertion(rdfs:label "nuclear receptor-mediated steroid hormone signaling pathway") -SubClassOf( ) -SubClassOf( ) - -# Class: (intracellular receptor signaling pathway) - -AnnotationAssertion(Annotation( "GOC:bf") Annotation( "GOC:mah") "The series of molecular signals initiated by a ligand binding to a receptor located within a cell.") -AnnotationAssertion( "intracellular receptor mediated signaling pathway") -AnnotationAssertion( "intracellular receptor-mediated signaling pathway") -AnnotationAssertion( "intracellular receptor-mediated signalling pathway") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "GO:0030522") -AnnotationAssertion(rdfs:label "intracellular receptor signaling pathway") -SubClassOf( ) - # Class: (male genitalia development) AnnotationAssertion(Annotation( "GOC:ems") Annotation( "ISBN:0140512888") "The process whose specific outcome is the progression of the male genitalia over time, from its formation to the mature structure.") @@ -43592,7 +42788,6 @@ SubClassOf( ObjectSomeValuesFrom( (bile acid catabolic process) AnnotationAssertion(Annotation( "GOC:go_curators") "The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile.") -AnnotationAssertion( "GO:0019613") AnnotationAssertion( "bile acid breakdown") AnnotationAssertion( "bile acid catabolism") AnnotationAssertion( "bile acid degradation") @@ -44112,7 +43307,6 @@ SubClassOf( ObjectSomeValuesFrom( (extracellular matrix) AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mah") Annotation( "GOC:rph") Annotation( "NIF_Subcellular:nlx_subcell_20090513") Annotation( "PMID:21123617") Annotation( "PMID:28089324") "A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.") -AnnotationAssertion( "GO:0005578") AnnotationAssertion( "NIF_Subcellular:nlx_subcell_20090513") AnnotationAssertion( "Wikipedia:Extracellular_matrix") AnnotationAssertion( "proteinaceous extracellular matrix") @@ -44177,6 +43371,19 @@ AnnotationAssertion(rdfs:label "nucl EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (microtubule organizing center organization) + +AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:jl") Annotation( "GOC:mah") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow.") +AnnotationAssertion( "microtubule organising center organisation") +AnnotationAssertion( "biological_process") +AnnotationAssertion(Annotation( "GOC:mah") "microtubule organizing center organization and biogenesis") +AnnotationAssertion( "GO:0031023") +AnnotationAssertion( ) +AnnotationAssertion(rdfs:label "microtubule organizing center organization") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (actomyosin structure organization) AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:jl") Annotation( "GOC:mah") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments.") @@ -44561,180 +43768,6 @@ EquivalentClasses( ObjectIntersection SubClassOf( ) SubClassOf( ) -# Class: (regulation of cellular metabolic process) - -AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.") -AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/27189"^^xsd:anyURI) -AnnotationAssertion( "regulation of cellular metabolism") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "GO:0031323") -AnnotationAssertion( ) -AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") -AnnotationAssertion(rdfs:label "regulation of cellular metabolic process") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) -SubClassOf( ) - -# Class: (negative regulation of cellular metabolic process) - -AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.") -AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/27189"^^xsd:anyURI) -AnnotationAssertion( "down regulation of cellular metabolic process") -AnnotationAssertion( "down-regulation of cellular metabolic process") -AnnotationAssertion( "downregulation of cellular metabolic process") -AnnotationAssertion( "negative regulation of cellular metabolism") -AnnotationAssertion( "inhibition of cellular metabolic process") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "GO:0031324") -AnnotationAssertion( ) -AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") -AnnotationAssertion(rdfs:label "negative regulation of cellular metabolic process") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) -SubClassOf( ) -SubClassOf( ) - -# Class: (positive regulation of cellular metabolic process) - -AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.") -AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/27189"^^xsd:anyURI) -AnnotationAssertion( "positive regulation of cellular metabolism") -AnnotationAssertion( "up regulation of cellular metabolic process") -AnnotationAssertion( "up-regulation of cellular metabolic process") -AnnotationAssertion( "upregulation of cellular metabolic process") -AnnotationAssertion( "activation of cellular metabolic process") -AnnotationAssertion( "stimulation of cellular metabolic process") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "GO:0031325") -AnnotationAssertion( ) -AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") -AnnotationAssertion(rdfs:label "positive regulation of cellular metabolic process") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) -SubClassOf( ) -SubClassOf( ) - -# Class: (regulation of cellular biosynthetic process) - -AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.") -AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/27189"^^xsd:anyURI) -AnnotationAssertion( "regulation of cellular anabolism") -AnnotationAssertion( "regulation of cellular biosynthesis") -AnnotationAssertion( "regulation of cellular formation") -AnnotationAssertion( "regulation of cellular synthesis") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "GO:0031326") -AnnotationAssertion( ) -AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") -AnnotationAssertion(rdfs:label "regulation of cellular biosynthetic process") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) -SubClassOf( ) - -# Class: (negative regulation of cellular biosynthetic process) - -AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.") -AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/27189"^^xsd:anyURI) -AnnotationAssertion( "down regulation of cellular biosynthetic process") -AnnotationAssertion( "down-regulation of cellular biosynthetic process") -AnnotationAssertion( "downregulation of cellular biosynthetic process") -AnnotationAssertion( "negative regulation of cellular anabolism") -AnnotationAssertion( "negative regulation of cellular biosynthesis") -AnnotationAssertion( "negative regulation of cellular formation") -AnnotationAssertion( "negative regulation of cellular synthesis") -AnnotationAssertion( "inhibition of cellular biosynthetic process") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "GO:0031327") -AnnotationAssertion( ) -AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") -AnnotationAssertion(rdfs:label "negative regulation of cellular biosynthetic process") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) -SubClassOf( ) -SubClassOf( ) - -# Class: (positive regulation of cellular biosynthetic process) - -AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.") -AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/27189"^^xsd:anyURI) -AnnotationAssertion( "positive regulation of cellular anabolism") -AnnotationAssertion( "positive regulation of cellular biosynthesis") -AnnotationAssertion( "positive regulation of cellular formation") -AnnotationAssertion( "positive regulation of cellular synthesis") -AnnotationAssertion( "up regulation of cellular biosynthetic process") -AnnotationAssertion( "up-regulation of cellular biosynthetic process") -AnnotationAssertion( "upregulation of cellular biosynthetic process") -AnnotationAssertion( "activation of cellular biosynthetic process") -AnnotationAssertion( "stimulation of cellular biosynthetic process") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "GO:0031328") -AnnotationAssertion( ) -AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") -AnnotationAssertion(rdfs:label "positive regulation of cellular biosynthetic process") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) -SubClassOf( ) -SubClassOf( ) - -# Class: (regulation of cellular catabolic process) - -AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.") -AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/27189"^^xsd:anyURI) -AnnotationAssertion( "regulation of cellular breakdown") -AnnotationAssertion( "regulation of cellular catabolism") -AnnotationAssertion( "regulation of cellular degradation") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "GO:0031329") -AnnotationAssertion( ) -AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") -AnnotationAssertion(rdfs:label "regulation of cellular catabolic process") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) -SubClassOf( ) - -# Class: (negative regulation of cellular catabolic process) - -AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.") -AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/27189"^^xsd:anyURI) -AnnotationAssertion( "down regulation of cellular catabolic process") -AnnotationAssertion( "down-regulation of cellular catabolic process") -AnnotationAssertion( "downregulation of cellular catabolic process") -AnnotationAssertion( "negative regulation of cellular breakdown") -AnnotationAssertion( "negative regulation of cellular catabolism") -AnnotationAssertion( "negative regulation of cellular degradation") -AnnotationAssertion( "inhibition of cellular catabolic process") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "GO:0031330") -AnnotationAssertion( ) -AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") -AnnotationAssertion(rdfs:label "negative regulation of cellular catabolic process") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) -SubClassOf( ) -SubClassOf( ) - -# Class: (positive regulation of cellular catabolic process) - -AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.") -AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/27189"^^xsd:anyURI) -AnnotationAssertion( "positive regulation of cellular breakdown") -AnnotationAssertion( "positive regulation of cellular catabolism") -AnnotationAssertion( "positive regulation of cellular degradation") -AnnotationAssertion( "up regulation of cellular catabolic process") -AnnotationAssertion( "up-regulation of cellular catabolic process") -AnnotationAssertion( "upregulation of cellular catabolic process") -AnnotationAssertion( "activation of cellular catabolic process") -AnnotationAssertion( "stimulation of cellular catabolic process") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "GO:0031331") -AnnotationAssertion( ) -AnnotationAssertion(rdfs:comment "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.") -AnnotationAssertion(rdfs:label "positive regulation of cellular catabolic process") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) -SubClassOf( ) -SubClassOf( ) - # Class: (negative regulation of protein-containing complex assembly) AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly.") @@ -44932,6 +43965,7 @@ AnnotationAssertion( "inhibition of protein modification") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0031400") +AnnotationAssertion( ) AnnotationAssertion(rdfs:label "negative regulation of protein modification process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) @@ -44945,6 +43979,7 @@ AnnotationAssertion( "stimulation of protein modification") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0031401") +AnnotationAssertion( ) AnnotationAssertion(rdfs:label "positive regulation of protein modification process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) @@ -44969,7 +44004,6 @@ EquivalentClasses( ObjectIntersection # Class: (cytoplasmic vesicle) AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:mah") Annotation( "GOC:vesicles") "A vesicle found in the cytoplasm of a cell.") -AnnotationAssertion( "GO:0016023") AnnotationAssertion( "NIF_Subcellular:sao180601769") AnnotationAssertion( "cellular_component") AnnotationAssertion( "cytoplasmic membrane bounded vesicle") @@ -45001,7 +44035,6 @@ SubClassOf( ObjectSomeValuesFrom( "GOC:mah") "A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/22021"^^xsd:anyURI) -AnnotationAssertion( "GO:0034629") AnnotationAssertion( "establishment and maintenance of protein complex localization") AnnotationAssertion(Annotation( "GOC:mah") "protein complex localisation") AnnotationAssertion( "biological_process") @@ -45017,8 +44050,6 @@ EquivalentClasses( ObjectIntersection # Class: (motile cilium) AnnotationAssertion(Annotation( "GOC:cilia") Annotation( "GOC:dgh") Annotation( "GOC:kmv") Annotation( "PMID:17009929") Annotation( "PMID:20144998") Annotation( "PMID:22118931") "A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell.") -AnnotationAssertion( "GO:0009434") -AnnotationAssertion( "GO:0031512") AnnotationAssertion( "motile cilia") AnnotationAssertion( "cellular_component") AnnotationAssertion( "microtubule-based flagellum") @@ -45235,7 +44266,7 @@ AnnotationAssertion( "regulation of glucocorticoid metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) -SubClassOf( ) +SubClassOf( ) SubClassOf( ) # Class: (negative regulation of glucocorticoid metabolic process) @@ -45250,7 +44281,7 @@ AnnotationAssertion( "GO:0031944") AnnotationAssertion(rdfs:label "negative regulation of glucocorticoid metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) +SubClassOf( ) SubClassOf( ) SubClassOf( ) SubClassOf( ) @@ -45268,7 +44299,7 @@ AnnotationAssertion( "GO:0031945") AnnotationAssertion(rdfs:label "positive regulation of glucocorticoid metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) +SubClassOf( ) SubClassOf( ) SubClassOf( ) SubClassOf( ) @@ -45317,15 +44348,17 @@ SubClassOf( (regulation of glucocorticoid catabolic process) AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids.") +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/29024"^^xsd:anyURI) AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0031949") AnnotationAssertion(rdfs:label "regulation of glucocorticoid catabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) +SubClassOf( ) # Class: (negative regulation of glucocorticoid catabolic process) AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids.") +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/29024"^^xsd:anyURI) AnnotationAssertion( "down regulation of glucocorticoid catabolic process") AnnotationAssertion( "down-regulation of glucocorticoid catabolic process") AnnotationAssertion( "downregulation of glucocorticoid catabolic process") @@ -45334,7 +44367,7 @@ AnnotationAssertion( "GO:0031950") AnnotationAssertion(rdfs:label "negative regulation of glucocorticoid catabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) +SubClassOf( ) # Class: (positive regulation of glucocorticoid catabolic process) @@ -45348,17 +44381,7 @@ AnnotationAssertion( "GO:0031951") AnnotationAssertion(rdfs:label "positive regulation of glucocorticoid catabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) - -# Class: (nuclear receptor-mediated corticosteroid signaling pathway) - -AnnotationAssertion(Annotation( "PMID:11027914") Annotation( "PMID:12606724") "A nuclear receptor-mediated signaling pathway initiated by a corticosteroid binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.") -AnnotationAssertion( "corticosteroid receptor signalling pathway") -AnnotationAssertion( "intracellular corticosteroid receptor signaling pathway") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "GO:0031958") -AnnotationAssertion(rdfs:label "nuclear receptor-mediated corticosteroid signaling pathway") -SubClassOf( ) +SubClassOf( ) # Class: (nuclear membrane) @@ -45413,7 +44436,6 @@ SubClassOf( ObjectSomeValuesFrom( (vesicle) AnnotationAssertion(Annotation( "GOC:mah") Annotation( "GOC:pz") Annotation( "GOC:vesicles") "Any small, fluid-filled, spherical organelle enclosed by membrane.") -AnnotationAssertion( "GO:0031988") AnnotationAssertion( "NIF_Subcellular:sao221389602") AnnotationAssertion( "Wikipedia:Vesicle_(biology)") AnnotationAssertion( "cellular_component") @@ -45458,6 +44480,18 @@ AnnotationAssertion( "bile acid binding") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (ciliary basal body organization) + +AnnotationAssertion(Annotation( "GOC:cilia") Annotation( "GOC:dph") Annotation( "GOC:jl") Annotation( "GOC:krc") Annotation( "GOC:mah") Annotation( "PMID:9889124") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ciliary basal body, a short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum).") +AnnotationAssertion(Annotation( "GOC:mah") "microtubule basal body organisation") +AnnotationAssertion( "microtubule basal body organization") +AnnotationAssertion( "biological_process") +AnnotationAssertion(Annotation( "GOC:mah") "microtubule basal body organization and biogenesis") +AnnotationAssertion( "GO:0032053") +AnnotationAssertion(rdfs:label "ciliary basal body organization") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + # Class: (negative regulation of translational initiation in response to stress) AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents or reduces the rate of translation initiation as a result of a stimulus indicating the organism is under stress.") @@ -46131,7 +45165,7 @@ AnnotationAssertion( "GO:0032345") AnnotationAssertion(rdfs:label "negative regulation of aldosterone metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) +SubClassOf( ) SubClassOf( ) SubClassOf( ) SubClassOf( ) @@ -46149,7 +45183,7 @@ AnnotationAssertion( "GO:0032346") AnnotationAssertion(rdfs:label "positive regulation of aldosterone metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) +SubClassOf( ) SubClassOf( ) SubClassOf( ) SubClassOf( ) @@ -46249,7 +45283,7 @@ AnnotationAssertion( "GO:0032353") AnnotationAssertion(rdfs:label "negative regulation of hormone biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) +SubClassOf( ) SubClassOf( ) SubClassOf( ) @@ -46523,8 +45557,6 @@ EquivalentClasses( ObjectIntersection # Class: (actin filament bundle) AnnotationAssertion(Annotation( "GOC:mah") "An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.") -AnnotationAssertion( "GO:0000141") -AnnotationAssertion( "GO:0030482") AnnotationAssertion( "cellular_component") AnnotationAssertion(Annotation( "GOC:mah") "actin cable") AnnotationAssertion( "GO:0032432") @@ -46615,8 +45647,6 @@ AnnotationAssertion( ) AnnotationAssertion( "jl") AnnotationAssertion( "2012-09-19T16:07:47Z") -AnnotationAssertion( "GO:0044707") -AnnotationAssertion( "GO:0050874") AnnotationAssertion( "organismal physiological process") AnnotationAssertion( "biological_process") AnnotationAssertion( "single-multicellular organism process") @@ -46645,7 +45675,6 @@ DisjointClasses( ObjectSomeValuesFrom AnnotationAssertion(Annotation( "GOC:isa_complete") "A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.") AnnotationAssertion( "jl") AnnotationAssertion( "2012-12-19T12:21:31Z") -AnnotationAssertion( "GO:0044767") AnnotationAssertion( "development") AnnotationAssertion( "biological_process") AnnotationAssertion( "single-organism developmental process") @@ -46769,8 +45798,6 @@ SubClassOf( (type I interferon production) AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0126896631") Annotation( "PMID:15546383") Annotation( "PMID:16681834") "The appearance of type I interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.") -AnnotationAssertion( "GO:0045351") -AnnotationAssertion( "GO:0072641") AnnotationAssertion( "interferon type I production") AnnotationAssertion(Annotation( "GOC:mah") "type I IFN production") AnnotationAssertion( "type I interferon biosynthetic process") @@ -46785,8 +45812,6 @@ SubClassOf( (type II interferon production) AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:mah") Annotation( "PMID:15546383") "The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon.") -AnnotationAssertion( "GO:0042095") -AnnotationAssertion( "GO:0072643") AnnotationAssertion(Annotation( "GOC:mah") "IFNG production") AnnotationAssertion( "interferon-gamma production") AnnotationAssertion(Annotation( "GOC:mah") "type II IFN production") @@ -46801,8 +45826,6 @@ SubClassOf( (interleukin-1 beta production) AnnotationAssertion(Annotation( "GOC:mah") "The appearance of interleukin-1 beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.") -AnnotationAssertion( "GO:0050702") -AnnotationAssertion( "GO:0050720") AnnotationAssertion( "IL-1 beta production") AnnotationAssertion( "interleukin-1 beta biosynthetic process") AnnotationAssertion( "interleukin-1 beta secretion") @@ -46815,8 +45838,6 @@ SubClassOf( (interleukin-1 production) AnnotationAssertion(Annotation( "GOC:mah") "The appearance of interleukin-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.") -AnnotationAssertion( "GO:0042222") -AnnotationAssertion( "GO:0050701") AnnotationAssertion( "IL-1 production") AnnotationAssertion( "interleukin-1 biosynthetic process") AnnotationAssertion( "interleukin-1 secretion") @@ -46829,8 +45850,6 @@ SubClassOf( (interleukin-10 production) AnnotationAssertion(Annotation( "GOC:mah") "The appearance of interleukin-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.") -AnnotationAssertion( "GO:0042091") -AnnotationAssertion( "GO:0072608") AnnotationAssertion( "IL-10 production") AnnotationAssertion( "interleukin-10 biosynthetic process") AnnotationAssertion( "interleukin-10 secretion") @@ -46843,8 +45862,6 @@ SubClassOf( (interleukin-13 production) AnnotationAssertion(Annotation( "GOC:mah") "The appearance of interleukin-13 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.") -AnnotationAssertion( "GO:0042231") -AnnotationAssertion( "GO:0072611") AnnotationAssertion( "IL-13 production") AnnotationAssertion( "interleukin-13 biosynthetic process") AnnotationAssertion( "interleukin-13 secretion") @@ -46857,8 +45874,6 @@ SubClassOf( (interleukin-17 production) AnnotationAssertion(Annotation( "GOC:mah") Annotation( "GOC:rv") Annotation( "Wikipedia:Interleukin_17") "The appearance of any member of the interleukin-17 family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.") -AnnotationAssertion( "GO:0042235") -AnnotationAssertion( "GO:0072615") AnnotationAssertion(Annotation( "GOC:BHF") "CTLA-8 production") AnnotationAssertion(Annotation( "GOC:BHF") "Cytotoxic T-lymphocyte-associated antigen 8 production") AnnotationAssertion( "IL-17 production") @@ -46873,8 +45888,6 @@ SubClassOf( (interleukin-2 production) AnnotationAssertion(Annotation( "GOC:mah") "The appearance of interleukin-2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.") -AnnotationAssertion( "GO:0042094") -AnnotationAssertion( "GO:0070970") AnnotationAssertion( "IL-2 production") AnnotationAssertion( "interleukin-2 biosynthetic process") AnnotationAssertion( "interleukin-2 secretion") @@ -46887,8 +45900,6 @@ SubClassOf( (interleukin-22 production) AnnotationAssertion(Annotation( "GOC:mah") "The appearance of interleukin-22 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.") -AnnotationAssertion( "GO:0042239") -AnnotationAssertion( "GO:0072620") AnnotationAssertion( "IL-22 production") AnnotationAssertion(Annotation( "GOC:BHF") "IL22 production") AnnotationAssertion(Annotation( "GOC:BHF") "ILTIF production") @@ -46904,9 +45915,6 @@ SubClassOf( (interleukin-4 production) AnnotationAssertion(Annotation( "GOC:mah") "The appearance of interleukin-4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.") -AnnotationAssertion( "GO:0042097") -AnnotationAssertion( "GO:0042224") -AnnotationAssertion( "GO:0072602") AnnotationAssertion( "IL-4 production") AnnotationAssertion( "interleukin-4 biosynthetic process") AnnotationAssertion( "interleukin-4 secretion") @@ -46919,8 +45927,6 @@ SubClassOf( (interleukin-5 production) AnnotationAssertion(Annotation( "GOC:mah") "The appearance of interleukin-5 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.") -AnnotationAssertion( "GO:0042225") -AnnotationAssertion( "GO:0072603") AnnotationAssertion( "IL-5 production") AnnotationAssertion( "interleukin-5 biosynthetic process") AnnotationAssertion( "interleukin-5 secretion") @@ -46933,8 +45939,6 @@ SubClassOf( (interleukin-6 production) AnnotationAssertion(Annotation( "GOC:mah") "The appearance of interleukin-6 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.") -AnnotationAssertion( "GO:0042226") -AnnotationAssertion( "GO:0072604") AnnotationAssertion( "IL-6 production") AnnotationAssertion( "interleukin-6 biosynthetic process") AnnotationAssertion( "interleukin-6 secretion") @@ -46947,8 +45951,6 @@ SubClassOf( (interleukin-8 production) AnnotationAssertion(Annotation( "GOC:mah") "The appearance of interleukin-8 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.") -AnnotationAssertion( "GO:0042228") -AnnotationAssertion( "GO:0072606") AnnotationAssertion( "IL-8 production") AnnotationAssertion( "interleukin-8 biosynthetic process") AnnotationAssertion( "interleukin-8 secretion") @@ -46961,8 +45963,6 @@ SubClassOf( (interleukin-9 production) AnnotationAssertion(Annotation( "GOC:mah") "The appearance of interleukin-9 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.") -AnnotationAssertion( "GO:0042229") -AnnotationAssertion( "GO:0072607") AnnotationAssertion( "IL-9 production") AnnotationAssertion( "interleukin-9 biosynthetic process") AnnotationAssertion( "interleukin-9 secretion") @@ -46977,8 +45977,6 @@ SubClassOf( "GOC:mah") Annotation( "PMID:10891884") Annotation( "PMID:15560120") "The appearance of tumor necrosis factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Tumor necrosis factor is an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.") AnnotationAssertion( "sl") AnnotationAssertion( "2015-06-15T22:59:26Z") -AnnotationAssertion( "GO:0042533") -AnnotationAssertion( "GO:1990774") AnnotationAssertion( "TNF production") AnnotationAssertion( "cachectin production") AnnotationAssertion( "TNF alpha biosynthesis") @@ -47005,8 +46003,6 @@ SubClassOf( (regulation of type II interferon production) AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:mah") Annotation( "PMID:15546383") "Any process that modulates the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.") -AnnotationAssertion( "GO:0045072") -AnnotationAssertion( "GO:1902713") AnnotationAssertion( "regulation of interferon-gamma production") AnnotationAssertion( "regulation of interferon-gamma biosynthetic process") AnnotationAssertion( "regulation of interferon-gamma secretion") @@ -47018,8 +46014,6 @@ EquivalentClasses( ObjectIntersection # Class: (regulation of interleukin-1 beta production) AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate, or extent of interleukin-1 beta production.") -AnnotationAssertion( "GO:0050706") -AnnotationAssertion( "GO:0050722") AnnotationAssertion( "regulation of IL-1 beta production") AnnotationAssertion( "regulation of interleukin-1 beta biosynthetic process") AnnotationAssertion( "regulation of interleukin-1 beta secretion") @@ -47031,8 +46025,6 @@ EquivalentClasses( ObjectIntersection # Class: (regulation of interleukin-1 production) AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate, or extent of interleukin-1 production.") -AnnotationAssertion( "GO:0045360") -AnnotationAssertion( "GO:0050704") AnnotationAssertion( "regulation of IL-1 production") AnnotationAssertion( "regulation of interleukin-1 biosynthetic process") AnnotationAssertion( "regulation of interleukin-1 secretion") @@ -47044,8 +46036,6 @@ EquivalentClasses( ObjectIntersection # Class: (regulation of interleukin-10 production) AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate, or extent of interleukin-10 production.") -AnnotationAssertion( "GO:0045074") -AnnotationAssertion( "GO:2001179") AnnotationAssertion( "regulation of IL-10 production") AnnotationAssertion( "regulation of interleukin-10 biosynthetic process") AnnotationAssertion( "regulation of interleukin-10 secretion") @@ -47057,8 +46047,6 @@ EquivalentClasses( ObjectIntersection # Class: (regulation of interleukin-13 production) AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate, or extent of interleukin-13 production.") -AnnotationAssertion( "GO:0045366") -AnnotationAssertion( "GO:2000665") AnnotationAssertion( "regulation of IL-13 production") AnnotationAssertion( "regulation of interleukin-13 biosynthetic process") AnnotationAssertion( "regulation of interleukin-13 secretion") @@ -47070,8 +46058,6 @@ EquivalentClasses( ObjectIntersection # Class: (regulation of interleukin-17 production) AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:mah") Annotation( "PMID:16482511") "Any process that modulates the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines.") -AnnotationAssertion( "GO:0045378") -AnnotationAssertion( "GO:1905076") AnnotationAssertion(Annotation( "GOC:TermGenie") "regulation of CTLA-8 production") AnnotationAssertion( "regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion") AnnotationAssertion( "regulation of IL-17 production") @@ -47085,8 +46071,6 @@ EquivalentClasses( ObjectIntersection # Class: (regulation of interleukin-2 production) AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate, or extent of interleukin-2 production.") -AnnotationAssertion( "GO:0045076") -AnnotationAssertion( "GO:1900040") AnnotationAssertion( "regulation of IL-2 production") AnnotationAssertion( "regulation of interleukin-2 biosynthetic process") AnnotationAssertion( "regulation of interleukin-2 secretion") @@ -47098,7 +46082,6 @@ EquivalentClasses( ObjectIntersection # Class: (regulation of interleukin-22 production) AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate, or extent of interleukin-22 production.") -AnnotationAssertion( "GO:0045393") AnnotationAssertion( "regulation of IL-22 production") AnnotationAssertion( "regulation of interleukin-22 biosynthetic process") AnnotationAssertion( "biological_process") @@ -47109,8 +46092,6 @@ EquivalentClasses( ObjectIntersection # Class: (regulation of interleukin-4 production) AnnotationAssertion(Annotation( "GOC:mah") Annotation( "PMID:29778524") "Any process that modulates the frequency, rate, or extent of interleukin-4 production.") -AnnotationAssertion( "GO:0045402") -AnnotationAssertion( "GO:0150133") AnnotationAssertion( "regulation of IL-4 production") AnnotationAssertion( "regulation of interleukin-4 biosynthetic process") AnnotationAssertion( "regulation of interleukin-4 secretion") @@ -47122,8 +46103,6 @@ EquivalentClasses( ObjectIntersection # Class: (regulation of interleukin-5 production) AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate, or extent of interleukin-5 production.") -AnnotationAssertion( "GO:0045405") -AnnotationAssertion( "GO:2000662") AnnotationAssertion( "regulation of IL-5 production") AnnotationAssertion( "regulation of interleukin-5 biosynthetic process") AnnotationAssertion( "regulation of interleukin-5 secretion") @@ -47135,7 +46114,6 @@ EquivalentClasses( ObjectIntersection # Class: (regulation of interleukin-6 production) AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate, or extent of interleukin-6 production.") -AnnotationAssertion( "GO:0045408") AnnotationAssertion( "regulation of IL-6 production") AnnotationAssertion( "regulation of interleukin-6 biosynthetic process") AnnotationAssertion( "biological_process") @@ -47146,8 +46124,6 @@ EquivalentClasses( ObjectIntersection # Class: (regulation of interleukin-8 production) AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate, or extent of interleukin-8 production.") -AnnotationAssertion( "GO:0045414") -AnnotationAssertion( "GO:2000482") AnnotationAssertion( "regulation of IL-8 production") AnnotationAssertion( "regulation of interleukin-8 biosynthetic process") AnnotationAssertion( "regulation of interleukin-8 secretion") @@ -47159,7 +46135,6 @@ EquivalentClasses( ObjectIntersection # Class: (regulation of interleukin-9 production) AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate, or extent of interleukin-9 production.") -AnnotationAssertion( "GO:0045417") AnnotationAssertion( "regulation of IL-9 production") AnnotationAssertion( "regulation of interleukin-9 biosynthetic process") AnnotationAssertion( "biological_process") @@ -47172,8 +46147,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:mah") Annotation( "PMID:10891884") Annotation( "PMID:15560120") "Any process that modulates the frequency, rate or extent of tumor necrosis factor production.") AnnotationAssertion( "sl") AnnotationAssertion( "2015-07-09T19:50:02Z") -AnnotationAssertion( "GO:0042534") -AnnotationAssertion( "GO:1904467") AnnotationAssertion( "regulation of TNF production") AnnotationAssertion( "regulation of TNF-alpha production") AnnotationAssertion(Annotation( "GOC:TermGenie") "regulation of cachectin production") @@ -47189,8 +46162,6 @@ EquivalentClasses( ObjectIntersection # Class: (negative regulation of type II interferon production) AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:mah") Annotation( "PMID:15546383") "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.") -AnnotationAssertion( "GO:0045077") -AnnotationAssertion( "GO:1902714") AnnotationAssertion( "down regulation of interferon-gamma production") AnnotationAssertion( "down-regulation of interferon-gamma production") AnnotationAssertion( "downregulation of interferon-gamma production") @@ -47206,8 +46177,6 @@ EquivalentClasses( ObjectIntersection # Class: (negative regulation of interleukin-1 beta production) AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production.") -AnnotationAssertion( "GO:0050713") -AnnotationAssertion( "GO:0050724") AnnotationAssertion( "down regulation of interleukin-1 beta production") AnnotationAssertion( "down-regulation of interleukin-1 beta production") AnnotationAssertion( "downregulation of interleukin-1 beta production") @@ -47223,8 +46192,6 @@ EquivalentClasses( ObjectIntersection # Class: (negative regulation of interleukin-1 production) AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 production.") -AnnotationAssertion( "GO:0045361") -AnnotationAssertion( "GO:0050711") AnnotationAssertion( "down regulation of interleukin-1 production") AnnotationAssertion( "down-regulation of interleukin-1 production") AnnotationAssertion( "downregulation of interleukin-1 production") @@ -47240,8 +46207,6 @@ EquivalentClasses( ObjectIntersection # Class: (negative regulation of interleukin-10 production) AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production.") -AnnotationAssertion( "GO:0045081") -AnnotationAssertion( "GO:2001180") AnnotationAssertion( "down regulation of interleukin-10 production") AnnotationAssertion( "down-regulation of interleukin-10 production") AnnotationAssertion( "downregulation of interleukin-10 production") @@ -47257,8 +46222,6 @@ EquivalentClasses( ObjectIntersection # Class: (negative regulation of interleukin-13 production) AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-13 production.") -AnnotationAssertion( "GO:0045367") -AnnotationAssertion( "GO:2000666") AnnotationAssertion( "down regulation of interleukin-13 production") AnnotationAssertion( "down-regulation of interleukin-13 production") AnnotationAssertion( "downregulation of interleukin-13 production") @@ -47274,8 +46237,6 @@ EquivalentClasses( ObjectIntersection # Class: (negative regulation of interleukin-17 production) AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:mah") Annotation( "PMID:16482511") "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines.") -AnnotationAssertion( "GO:0045379") -AnnotationAssertion( "GO:1905077") AnnotationAssertion( "down regulation of interleukin-17 production") AnnotationAssertion( "downregulation of interleukin-17 production") AnnotationAssertion(Annotation( "GOC:TermGenie") "negative regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion") @@ -47292,8 +46253,6 @@ EquivalentClasses( ObjectIntersection # Class: (negative regulation of interleukin-2 production) AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production.") -AnnotationAssertion( "GO:0045085") -AnnotationAssertion( "GO:1900041") AnnotationAssertion( "down regulation of interleukin-2 production") AnnotationAssertion( "down-regulation of interleukin-2 production") AnnotationAssertion( "downregulation of interleukin-2 production") @@ -47309,7 +46268,6 @@ EquivalentClasses( ObjectIntersection # Class: (negative regulation of interleukin-22 production) AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-22 production.") -AnnotationAssertion( "GO:0045394") AnnotationAssertion( "down regulation of interleukin-22 production") AnnotationAssertion( "down-regulation of interleukin-22 production") AnnotationAssertion( "downregulation of interleukin-22 production") @@ -47325,8 +46283,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:mah") Annotation( "PMID:29778524") "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-4 production.") AnnotationAssertion( "bc") -AnnotationAssertion( "GO:0045403") -AnnotationAssertion( "GO:0150134") AnnotationAssertion( "down regulation of interleukin-4 production") AnnotationAssertion( "down-regulation of interleukin-4 production") AnnotationAssertion( "downregulation of interleukin-4 production") @@ -47342,8 +46298,6 @@ EquivalentClasses( ObjectIntersection # Class: (negative regulation of interleukin-5 production) AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-5 production.") -AnnotationAssertion( "GO:0045406") -AnnotationAssertion( "GO:2000663") AnnotationAssertion( "down regulation of interleukin-5 production") AnnotationAssertion( "down-regulation of interleukin-5 production") AnnotationAssertion( "downregulation of interleukin-5 production") @@ -47359,8 +46313,6 @@ EquivalentClasses( ObjectIntersection # Class: (negative regulation of interleukin-6 production) AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production.") -AnnotationAssertion( "GO:0045409") -AnnotationAssertion( "GO:1900165") AnnotationAssertion( "down regulation of interleukin-6 production") AnnotationAssertion( "down-regulation of interleukin-6 production") AnnotationAssertion( "downregulation of interleukin-6 production") @@ -47376,8 +46328,6 @@ EquivalentClasses( ObjectIntersection # Class: (negative regulation of interleukin-8 production) AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-8 production.") -AnnotationAssertion( "GO:0045415") -AnnotationAssertion( "GO:2000483") AnnotationAssertion( "down regulation of interleukin-8 production") AnnotationAssertion( "down-regulation of interleukin-8 production") AnnotationAssertion( "downregulation of interleukin-8 production") @@ -47393,7 +46343,6 @@ EquivalentClasses( ObjectIntersection # Class: (negative regulation of interleukin-9 production) AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-9 production.") -AnnotationAssertion( "GO:0045418") AnnotationAssertion( "down regulation of interleukin-9 production") AnnotationAssertion( "down-regulation of interleukin-9 production") AnnotationAssertion( "downregulation of interleukin-9 production") @@ -47410,8 +46359,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:mah") Annotation( "PMID:10891884") Annotation( "PMID:15560120") "Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.") AnnotationAssertion( "sl") AnnotationAssertion( "2015-07-09T19:50:08Z") -AnnotationAssertion( "GO:0042536") -AnnotationAssertion( "GO:1904468") AnnotationAssertion( "down regulation of tumor necrosis factor production") AnnotationAssertion( "down-regulation of tumor necrosis factor production") AnnotationAssertion( "downregulation of tumor necrosis factor production") @@ -47431,8 +46378,6 @@ EquivalentClasses( ObjectIntersection # Class: (positive regulation of type II interferon production) AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:mah") Annotation( "PMID:15546383") "Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.") -AnnotationAssertion( "GO:0045078") -AnnotationAssertion( "GO:1902715") AnnotationAssertion( "positive regulation of interferon-gamma production") AnnotationAssertion( "up regulation of interferon-gamma production") AnnotationAssertion( "up-regulation of interferon-gamma production") @@ -47451,8 +46396,6 @@ SubClassOf( ObjectAllValuesFrom( (positive regulation of interleukin-1 beta production) AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate, or extent of interleukin-1 beta production.") -AnnotationAssertion( "GO:0050718") -AnnotationAssertion( "GO:0050725") AnnotationAssertion( "positive regulation of IL-1 beta production") AnnotationAssertion( "up regulation of interleukin-1 beta production") AnnotationAssertion( "up-regulation of interleukin-1 beta production") @@ -47469,8 +46412,6 @@ EquivalentClasses( ObjectIntersection # Class: (positive regulation of interleukin-1 production) AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate, or extent of interleukin-1 production.") -AnnotationAssertion( "GO:0045362") -AnnotationAssertion( "GO:0050716") AnnotationAssertion( "positive regulation of IL-1 production") AnnotationAssertion( "up regulation of interleukin-1 production") AnnotationAssertion( "up-regulation of interleukin-1 production") @@ -47487,8 +46428,6 @@ EquivalentClasses( ObjectIntersection # Class: (positive regulation of interleukin-10 production) AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate, or extent of interleukin-10 production.") -AnnotationAssertion( "GO:0045082") -AnnotationAssertion( "GO:2001181") AnnotationAssertion( "positive regulation of IL-10 production") AnnotationAssertion( "up regulation of interleukin-10 production") AnnotationAssertion( "up-regulation of interleukin-10 production") @@ -47505,8 +46444,6 @@ EquivalentClasses( ObjectIntersection # Class: (positive regulation of interleukin-13 production) AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate, or extent of interleukin-13 production.") -AnnotationAssertion( "GO:0045368") -AnnotationAssertion( "GO:2000667") AnnotationAssertion( "positive regulation of IL-13 production") AnnotationAssertion( "up regulation of interleukin-13 production") AnnotationAssertion( "up-regulation of interleukin-13 production") @@ -47523,8 +46460,6 @@ EquivalentClasses( ObjectIntersection # Class: (positive regulation of interleukin-17 production) AnnotationAssertion(Annotation( "GOC:add") Annotation( "GOC:mah") Annotation( "PMID:16482511") "Any process that activates or increases the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines.") -AnnotationAssertion( "GO:0045380") -AnnotationAssertion( "GO:1905078") AnnotationAssertion(Annotation( "GOC:TermGenie") "positive regulation of CTLA-8 production") AnnotationAssertion(Annotation( "GOC:TermGenie") "positive regulation of Cytotoxic T-lymphocyte-associated antigen 8 production") AnnotationAssertion( "positive regulation of IL-17 production") @@ -47543,8 +46478,6 @@ EquivalentClasses( ObjectIntersection # Class: (positive regulation of interleukin-2 production) AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate, or extent of interleukin-2 production.") -AnnotationAssertion( "GO:0045086") -AnnotationAssertion( "GO:1900042") AnnotationAssertion( "positive regulation of IL-2 production") AnnotationAssertion( "up regulation of interleukin-2 production") AnnotationAssertion( "up-regulation of interleukin-2 production") @@ -47561,7 +46494,6 @@ EquivalentClasses( ObjectIntersection # Class: (positive regulation of interleukin-22 production) AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate, or extent of interleukin-22 production.") -AnnotationAssertion( "GO:0045395") AnnotationAssertion( "positive regulation of IL-22 production") AnnotationAssertion( "up regulation of interleukin-22 production") AnnotationAssertion( "up-regulation of interleukin-22 production") @@ -47577,8 +46509,6 @@ EquivalentClasses( ObjectIntersection # Class: (positive regulation of interleukin-4 production) AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate, or extent of interleukin-4 production.") -AnnotationAssertion( "GO:0045404") -AnnotationAssertion( "GO:0150135") AnnotationAssertion( "positive regulation of IL-4 production") AnnotationAssertion( "up regulation of interleukin-4 production") AnnotationAssertion( "up-regulation of interleukin-4 production") @@ -47595,8 +46525,6 @@ EquivalentClasses( ObjectIntersection # Class: (positive regulation of interleukin-5 production) AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate, or extent of interleukin-5 production.") -AnnotationAssertion( "GO:0045407") -AnnotationAssertion( "GO:2000664") AnnotationAssertion( "positive regulation of IL-5 production") AnnotationAssertion( "up regulation of interleukin-5 production") AnnotationAssertion( "up-regulation of interleukin-5 production") @@ -47613,8 +46541,6 @@ EquivalentClasses( ObjectIntersection # Class: (positive regulation of interleukin-6 production) AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate, or extent of interleukin-6 production.") -AnnotationAssertion( "GO:0045410") -AnnotationAssertion( "GO:2000778") AnnotationAssertion( "positive regulation of IL-6 production") AnnotationAssertion( "up regulation of interleukin-6 production") AnnotationAssertion( "up-regulation of interleukin-6 production") @@ -47633,8 +46559,6 @@ SubClassOf( ObjectAllValuesFrom( (positive regulation of interleukin-8 production) AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate, or extent of interleukin-8 production.") -AnnotationAssertion( "GO:0045416") -AnnotationAssertion( "GO:2000484") AnnotationAssertion( "positive regulation of IL-8 production") AnnotationAssertion( "up regulation of interleukin-8 production") AnnotationAssertion( "up-regulation of interleukin-8 production") @@ -47651,7 +46575,6 @@ EquivalentClasses( ObjectIntersection # Class: (positive regulation of interleukin-9 production) AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate, or extent of interleukin-9 production.") -AnnotationAssertion( "GO:0045419") AnnotationAssertion( "positive regulation of IL-9 production") AnnotationAssertion( "up regulation of interleukin-9 production") AnnotationAssertion( "up-regulation of interleukin-9 production") @@ -47669,8 +46592,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:10891884") Annotation( "PMID:15560120") "Any process that activates or increases the frequency, rate or extent of tumor necrosis factor production.") AnnotationAssertion( "sl") AnnotationAssertion( "2015-07-09T19:50:14Z") -AnnotationAssertion( "GO:0042535") -AnnotationAssertion( "GO:1904469") AnnotationAssertion( "positive regulation of TNF production") AnnotationAssertion( "positive regulation of TNF-alpha production") AnnotationAssertion( "positive regulation of tumor necrosis factor-alpha production") @@ -47738,7 +46659,6 @@ EquivalentClasses( ObjectIntersection # Class: (RNA biosynthetic process) AnnotationAssertion(Annotation( "GOC:mah") Annotation( "GOC:txnOH") "The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication.") -AnnotationAssertion( "GO:0062103") AnnotationAssertion( "RNA anabolism") AnnotationAssertion( "RNA biosynthesis") AnnotationAssertion( "RNA formation") @@ -48272,7 +47192,6 @@ AnnotationAssertion(Annotation( "https://github.com/geneontology/go-ontology/issues/22021"^^xsd:anyURI) AnnotationAssertion( "jl") AnnotationAssertion( "2015-01-20T14:32:14Z") -AnnotationAssertion( "GO:1903827") AnnotationAssertion(Annotation( "GOC:TermGenie") "regulation of cellular protein localisation") AnnotationAssertion( "regulation of cellular protein localization") AnnotationAssertion(Annotation( "GOC:mah") "regulation of protein localisation") @@ -48539,7 +47458,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:jl") "The directed movement of amino acids from inside of a cell, across the plasma membrane and into the extracellular region.") AnnotationAssertion( "jl") AnnotationAssertion( "2012-11-14T14:27:40Z") -AnnotationAssertion( "GO:0044746") AnnotationAssertion( "amino acid export") AnnotationAssertion( "amino acid transmembrane export") AnnotationAssertion( "amino acid efflux") @@ -48593,9 +47511,6 @@ SubClassOf( "GOC:mah") "The disaggregation of a protein-containing macromolecular complex into its constituent components.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/22580"^^xsd:anyURI) -AnnotationAssertion( "GO:0034623") -AnnotationAssertion( "GO:0043241") -AnnotationAssertion( "GO:0043624") AnnotationAssertion( "protein complex disassembly") AnnotationAssertion( "biological_process") AnnotationAssertion( "cellular macromolecule complex disassembly") @@ -48644,7 +47559,6 @@ SubClassOf( (protein-containing complex) AnnotationAssertion(Annotation( "GOC:dos") Annotation( "GOC:mah") "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.") -AnnotationAssertion( "GO:0043234") AnnotationAssertion( "macromolecular complex") AnnotationAssertion( "macromolecule complex") AnnotationAssertion( "protein containing complex") @@ -49127,36 +48041,6 @@ AnnotationAssertion( "positive regulation of immature T cell proliferation in thymus") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -# Class: (regulation of intracellular steroid hormone receptor signaling pathway) - -AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway.") -AnnotationAssertion(Annotation( "GOC:bf") "regulation of steroid hormone receptor signaling pathway") -AnnotationAssertion( "regulation of steroid hormone receptor signalling pathway") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "GO:0033143") -AnnotationAssertion(rdfs:label "regulation of intracellular steroid hormone receptor signaling pathway") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) - -# Class: (negative regulation of intracellular steroid hormone receptor signaling pathway) - -AnnotationAssertion(Annotation( "GOC:mah") "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway.") -AnnotationAssertion(Annotation( "GOC:bf") "negative regulation of steroid hormone receptor signaling pathway") -AnnotationAssertion(Annotation( "GOC:bf") "negative regulation of steroid hormone receptor signalling pathway") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "GO:0033144") -AnnotationAssertion(rdfs:label "negative regulation of intracellular steroid hormone receptor signaling pathway") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) - -# Class: (positive regulation of intracellular steroid hormone receptor signaling pathway) - -AnnotationAssertion(Annotation( "GOC:mah") "Any process that activates or increases the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway.") -AnnotationAssertion(Annotation( "GOC:bf") "positive regulation of steroid hormone receptor signaling pathway") -AnnotationAssertion( "positive regulation of steroid hormone receptor signalling pathway") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "GO:0033145") -AnnotationAssertion(rdfs:label "positive regulation of intracellular steroid hormone receptor signaling pathway") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) - # Class: (V(D)J recombination) AnnotationAssertion(Annotation( "GOC:add") Annotation( "ISBN:0781700221") Annotation( "ISBN:0781735149") "The process in which immune receptor V, D, and J, or V and J gene segments, depending on the specific receptor, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS).") @@ -49220,7 +48104,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "PMID:18622392") Annotation( "PMID:23192658") Annotation( "Wikipedia:Human_iron_metabolism") "The directed movement of iron ions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis.") AnnotationAssertion( "mah") AnnotationAssertion( "2009-05-01T04:19:14Z") -AnnotationAssertion( "GO:0070627") AnnotationAssertion( "ferrous ion import") AnnotationAssertion( "ferrous iron import") AnnotationAssertion( "ferrous iron uptake") @@ -49722,7 +48605,6 @@ EquivalentClasses( ObjectIntersection # Class: (ribosome localization) AnnotationAssertion(Annotation( "GOC:mah") "A process in which a ribosome is transported to, and/or maintained in, a specific location.") -AnnotationAssertion( "GO:0033753") AnnotationAssertion( "biological_process") AnnotationAssertion( "establishment of ribosome localisation") AnnotationAssertion( "establishment of ribosome localization") @@ -49753,8 +48635,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:mah") "A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus.") AnnotationAssertion( "mah") AnnotationAssertion( "2011-02-14T02:26:36Z") -AnnotationAssertion( "GO:0000042") -AnnotationAssertion( "GO:0072600") AnnotationAssertion(Annotation( "GOC:mah") "protein localisation in Golgi apparatus") AnnotationAssertion( "protein localization in Golgi apparatus") AnnotationAssertion(Annotation( "GOC:mah") "establishment of protein localisation to Golgi") @@ -49876,7 +48756,6 @@ EquivalentClasses( ObjectIntersection # Class: (monoatomic ion transmembrane transport) AnnotationAssertion(Annotation( "GOC:mah") "A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom.") -AnnotationAssertion( "GO:0099131") AnnotationAssertion( "ion transmembrane transport") AnnotationAssertion( "ion membrane transport") AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "transmembrane ion transport") @@ -50228,7 +49107,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:ecd") "A process in which a protein transports or maintains the localization of another protein to the nucleus.") AnnotationAssertion( "2012-11-07T15:45:54Z") -AnnotationAssertion( "GO:0044744") AnnotationAssertion(Annotation( "GOC:mah") "protein localisation to nucleus") AnnotationAssertion( "protein localization in cell nucleus") AnnotationAssertion(Annotation( "GOC:mah") "protein localization in nucleus") @@ -50336,10 +49214,6 @@ SubClassOf( "GOC:mah") Annotation( "PMID:11390404") "A process in which an iron ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.") AnnotationAssertion( "vw") AnnotationAssertion( "2015-02-06T11:29:22Z") -AnnotationAssertion( "GO:0000040") -AnnotationAssertion( "GO:0006827") -AnnotationAssertion( "GO:0061839") -AnnotationAssertion( "GO:1903874") AnnotationAssertion( "iron ion membrane transport") AnnotationAssertion( "transmembrane iron transport") AnnotationAssertion( "ferrous ion transmembrane transport") @@ -50364,7 +49238,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of the directed movement of iron ions (Fe) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.") AnnotationAssertion( "mah") AnnotationAssertion( "2012-04-18T04:00:14Z") -AnnotationAssertion( "GO:1900390") AnnotationAssertion( "regulation of Fe transport") AnnotationAssertion( "regulation of iron transport") AnnotationAssertion(Annotation( "GOC:TermGenie") "regulation of iron import") @@ -50527,7 +49400,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:sart") Annotation( "PMID:17301221") "The controlled breakdown of the basement membrane in the context of a normal process such as imaginal disc eversion.") AnnotationAssertion( "dph") AnnotationAssertion( "2009-08-13T11:27:24Z") -AnnotationAssertion( "GO:0060881") AnnotationAssertion( "biological_process") AnnotationAssertion( "basal lamina disassembly") AnnotationAssertion( "GO:0034769") @@ -50633,8 +49505,6 @@ SubClassOf( ObjectSomeValuesFrom( (axoneme assembly) AnnotationAssertion(Annotation( "GOC:bf") Annotation( "GOC:cilia") Annotation( "GOC:jl") Annotation( "ISBN:0815316194") "The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.") -AnnotationAssertion( "GO:0035083") -AnnotationAssertion( "GO:0035084") AnnotationAssertion( "ciliary axoneme assembly") AnnotationAssertion( "cilium axoneme assembly") AnnotationAssertion( "flagellar axoneme assembly") @@ -50700,7 +49570,6 @@ SubClassOf( ObjectSomeValuesFrom( (forelimb morphogenesis) AnnotationAssertion(Annotation( "GOC:go_curators") "The process in which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human.") -AnnotationAssertion( "GO:0035140") AnnotationAssertion(Annotation( "GOC:bf") Annotation( "GOC:cjm") "arm morphogenesis") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0035136") @@ -51221,10 +50090,6 @@ SubClassOf( "GOC:bf") Annotation( "GOC:jl") Annotation( "GOC:signaling") Annotation( "ISBN:3527303782") "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.") AnnotationAssertion( "bf") AnnotationAssertion( "2010-05-14T01:14:37Z") -AnnotationAssertion( "GO:0007242") -AnnotationAssertion( "GO:0007243") -AnnotationAssertion( "GO:0023013") -AnnotationAssertion( "GO:0023034") AnnotationAssertion( "intracellular signal transduction pathway") AnnotationAssertion( "signal transmission via intracellular cascade") AnnotationAssertion( "biological_process") @@ -52396,6 +51261,25 @@ DisjointClasses( ObjectSomeValuesFrom DisjointClasses( ObjectSomeValuesFrom( )) DisjointClasses( ObjectSomeValuesFrom( )) +# Class: (ciliary basal body) + +AnnotationAssertion(Annotation( "GOC:cilia") Annotation( "GOC:clt") Annotation( "PMID:21750193") "A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodeling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.") +AnnotationAssertion( "bf") +AnnotationAssertion( "2011-12-15T10:40:20Z") +AnnotationAssertion( "basal body") +AnnotationAssertion( "NIF_Subcellular:sao11978067") +AnnotationAssertion( "cilial basal body") +AnnotationAssertion(Annotation( "GOC:bf") "cilium basal body") +AnnotationAssertion(Annotation( "PMID:11125699") "kinetosome") +AnnotationAssertion( "microtubule basal body") +AnnotationAssertion( "cellular_component") +AnnotationAssertion( "GO:0036064") +AnnotationAssertion(rdfs:comment "In most eukaryotic cells, 'ciliary basal body' (GO:0036064) and 'centriole' (GO:0005814) represent a common entity that cycles through its function in cell division, then ciliogenesis, then cell division again. However, these structures are modified extensively as they transition into each other, and may contain different proteins, specific to each component.") +AnnotationAssertion(rdfs:label "ciliary basal body") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectSomeValuesFrom( )) + # Class: (direct ossification) AnnotationAssertion(Annotation( "GO_REF:0000034") "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance, that does not require the replacement of preexisting tissues.") @@ -52617,7 +51501,6 @@ AnnotationAssertion(Annotation( "https://github.com/geneontology/go-ontology/issues/23112"^^xsd:anyURI) AnnotationAssertion( "bf") AnnotationAssertion( "2012-04-26T01:47:12Z") -AnnotationAssertion( "GO:0006464") AnnotationAssertion( "cellular protein modification process") AnnotationAssertion( "process resulting in protein modification") AnnotationAssertion(Annotation( "GOC:bf") "protein modification") @@ -52787,8 +51670,6 @@ SubClassOf( "GOC:vw") Annotation( "PMID:14674689") "The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region.") AnnotationAssertion( "mah") AnnotationAssertion( "2009-12-16T11:13:55Z") -AnnotationAssertion( "GO:0071436") -AnnotationAssertion( "GO:0098667") AnnotationAssertion( "sodium ion export from cell") AnnotationAssertion( "biological_process") AnnotationAssertion(Annotation( "GOC:mah") "sodium export") @@ -52880,8 +51761,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:bf") Annotation( "GOC:signaling") "Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.") AnnotationAssertion( "bf") AnnotationAssertion( "2011-08-01T02:45:27Z") -AnnotationAssertion( "GO:0004872") -AnnotationAssertion( "GO:0019041") AnnotationAssertion( "receptor activity") AnnotationAssertion(Annotation( "GOC:bf") "receptor activity involved in signal transduction") AnnotationAssertion( "signalling receptor activity") @@ -52907,6 +51786,7 @@ AnnotationAssertion( "2011-08-01T02:50:45Z") AnnotationAssertion( "receptor activity") AnnotationAssertion(Annotation( "GOC:signaling") "transport receptor activity") +AnnotationAssertion(Annotation(rdfs:label "eNOS:Caveolin-1 complex binds to Nostrin") "Reactome:R-HSA-203716") AnnotationAssertion(Annotation(rdfs:label "CUBN:AMN binds CBLIF:RCbl") "Reactome:R-HSA-3000103") AnnotationAssertion(Annotation(rdfs:label "CD320-mediated TCN2:RCbl uptake and delivery to lysosome") "Reactome:R-HSA-3000112") AnnotationAssertion(Annotation(rdfs:label "CD320 binds extracellular TCN2:RCbl") "Reactome:R-HSA-3000122") @@ -52981,7 +51861,6 @@ AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/18588"^^xsd:anyURI) AnnotationAssertion( "bf") AnnotationAssertion( "2013-05-29T15:24:44Z") -AnnotationAssertion( "GO:0008329") AnnotationAssertion( "Wikipedia:Pattern_recognition_receptor") AnnotationAssertion( "PRR") AnnotationAssertion(Annotation( "Wikipedia:Pattern_recognition_receptor") "PRR activity") @@ -53187,7 +52066,6 @@ SubClassOf( ObjectSomeValuesFrom( (growth) AnnotationAssertion(Annotation( "GOC:bf") Annotation( "GOC:ma") "The increase in size or mass of an entire organism, a part of an organism or a cell.") -AnnotationAssertion( "GO:0048590") AnnotationAssertion( "biological_process") AnnotationAssertion( "growth pattern") AnnotationAssertion(Annotation( "GOC:mah") "non-developmental growth") @@ -53443,7 +52321,6 @@ AnnotationAssertion( ) AnnotationAssertion( ) AnnotationAssertion( ) -AnnotationAssertion( "GO:0035734") AnnotationAssertion( "Wikipedia:Intraflagellar_transport") AnnotationAssertion( "intraflagellar transport") AnnotationAssertion( "intraflagellar transport involved in cilium organization") @@ -53489,7 +52366,6 @@ SubClassOf( (germ-line stem cell division) AnnotationAssertion(Annotation( "GOC:jid") Annotation( "PMID:2279698") "The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes.") -AnnotationAssertion( "GO:0048131") AnnotationAssertion( "germ-line stem cell renewal") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0042078") @@ -53531,7 +52407,6 @@ SubClassOf( (T cell proliferation) AnnotationAssertion(Annotation( "GOC:jl") "The expansion of a T cell population by cell division. Follows T cell activation.") -AnnotationAssertion( "GO:0042111") AnnotationAssertion( "T lymphocyte proliferation") AnnotationAssertion( "T-cell proliferation") AnnotationAssertion( "T-lymphocyte proliferation") @@ -53545,7 +52420,6 @@ SubClassOf( (B cell proliferation) AnnotationAssertion(Annotation( "GOC:jl") "The expansion of a B cell population by cell division. Follows B cell activation.") -AnnotationAssertion( "GO:0042114") AnnotationAssertion( "B lymphocyte proliferation") AnnotationAssertion( "B-cell proliferation") AnnotationAssertion( "B-lymphocyte proliferation") @@ -53824,8 +52698,6 @@ AnnotationAssertion(Annotation( "https://github.com/geneontology/go-ontology/issues/23112"^^xsd:anyURI) AnnotationAssertion( "kmv") AnnotationAssertion( "2014-08-21T15:05:45Z") -AnnotationAssertion( "GO:1903362") -AnnotationAssertion( "GO:2000598") AnnotationAssertion(Annotation( "GOC:TermGenie") "regulation of cellular protein breakdown") AnnotationAssertion( "regulation of cellular protein catabolic process") AnnotationAssertion(Annotation( "GOC:TermGenie") "regulation of cellular protein catabolism") @@ -53847,8 +52719,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:kmv") Annotation( "GOC:obol") Annotation( "GO_REF:0000058") Annotation( "PMID:24785082") "Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/23112"^^xsd:anyURI) -AnnotationAssertion( "GO:1903363") -AnnotationAssertion( "GO:2000599") AnnotationAssertion(Annotation( "GOC:TermGenie") "down regulation of cellular protein breakdown") AnnotationAssertion(Annotation( "GOC:TermGenie") "down regulation of cellular protein catabolic process") AnnotationAssertion(Annotation( "GOC:TermGenie") "down regulation of cellular protein catabolism") @@ -53881,18 +52751,16 @@ AnnotationAssertion( "negative regulation of protein catabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -# Class: (cellular ketone metabolic process) +# Class: (ketone metabolic process) AnnotationAssertion(Annotation( "GOC:jl") Annotation( "ISBN:0787650153") "The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.") +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/28908"^^xsd:anyURI) AnnotationAssertion( "ketone metabolism") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0042180") AnnotationAssertion( ) -AnnotationAssertion(rdfs:label "cellular ketone metabolic process") +AnnotationAssertion(rdfs:label "ketone metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) -SubClassOf( ) -SubClassOf( ) # Class: (ketone biosynthetic process) @@ -53906,7 +52774,6 @@ AnnotationAssertion( "ketone biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) -SubClassOf( ) SubClassOf( ) # Class: (ketone catabolic process) @@ -53919,25 +52786,25 @@ AnnotationAssertion( "GO:0042182") AnnotationAssertion(rdfs:label "ketone catabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) SubClassOf( ) -# Class: (cellular modified amino acid catabolic process) +# Class: (modified amino acid catabolic process) AnnotationAssertion(Annotation( "GOC:ai") "The chemical reactions and pathways resulting in the breakdown of compounds derived from amino acids, organic acids containing one or more amino substituents.") +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/28908"^^xsd:anyURI) AnnotationAssertion( "amino acid derivative catabolic process") AnnotationAssertion( "cellular amino acid derivative breakdown") AnnotationAssertion( "cellular amino acid derivative catabolic process") AnnotationAssertion( "cellular amino acid derivative catabolism") AnnotationAssertion( "cellular amino acid derivative degradation") AnnotationAssertion(Annotation( "GOC:mah") "cellular modified amino acid breakdown") +AnnotationAssertion(Annotation( "GOC:mah") "cellular modified amino acid catabolic process") AnnotationAssertion(Annotation( "GOC:mah") "cellular modified amino acid catabolism") AnnotationAssertion(Annotation( "GOC:mah") "cellular modified amino acid degradation") -AnnotationAssertion(Annotation( "GOC:mah") "modified amino acid catabolic process") AnnotationAssertion(Annotation( "GOC:mah") "modified amino acid catabolism") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0042219") -AnnotationAssertion(rdfs:label "cellular modified amino acid catabolic process") +AnnotationAssertion(rdfs:label "modified amino acid catabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (response to chemical) @@ -53976,7 +52843,6 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (ribosome biogenesis) AnnotationAssertion(Annotation( "GOC:ma") Annotation( "PMID:26404467") Annotation( "Wikipedia:Ribosome_biogenesis") "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.") -AnnotationAssertion( "GO:0007046") AnnotationAssertion( "ribosome biogenesis and assembly") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0042254") @@ -53994,7 +52860,6 @@ SubClassOf( (ribosome assembly) AnnotationAssertion(Annotation( "GOC:ma") Annotation( "PMID:30467428") "The aggregation, arrangement and bonding together of the mature ribosome and of its subunits.") -AnnotationAssertion( "GO:0042257") AnnotationAssertion(Annotation( "GOC:mah") Annotation( "GOC:vw") "ribosomal subunit assembly") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0042255") @@ -54236,9 +53101,10 @@ AnnotationAssertion( "regulation of membrane potential") SubClassOf( ObjectSomeValuesFrom( )) -# Class: (cellular modified amino acid biosynthetic process) +# Class: (modified amino acid biosynthetic process) AnnotationAssertion(Annotation( "GOC:ai") "The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents.") +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/28908"^^xsd:anyURI) AnnotationAssertion( "amino acid derivative biosynthetic process") AnnotationAssertion( "cellular amino acid derivative anabolism") AnnotationAssertion( "cellular amino acid derivative biosynthesis") @@ -54251,7 +53117,7 @@ AnnotationAssertion(Annotation( "GOC:mah") "cellular modified amino acid synthesis") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0042398") -AnnotationAssertion(rdfs:label "cellular modified amino acid biosynthetic process") +AnnotationAssertion(rdfs:label "modified amino acid biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (biogenic amine biosynthetic process) @@ -54268,15 +53134,16 @@ AnnotationAssertion(rdfs:label "biog SubClassOf( ) SubClassOf( ) -# Class: (cellular biogenic amine catabolic process) +# Class: (biogenic amine catabolic process) AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "GOC:jl") Annotation( "ISBN:0198506732") "The chemical reactions and pathways occurring at the level of individual cells resulting in the breakdown of biogenic amines, any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.") +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/28908"^^xsd:anyURI) AnnotationAssertion( "biogenic amine breakdown") AnnotationAssertion( "biogenic amine catabolism") AnnotationAssertion( "biogenic amine degradation") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0042402") -AnnotationAssertion(rdfs:label "cellular biogenic amine catabolic process") +AnnotationAssertion(rdfs:label "biogenic amine catabolic process") SubClassOf( ) # Class: (thyroid hormone metabolic process) @@ -54475,7 +53342,6 @@ EquivalentClasses( ObjectIntersection # Class: (indole-containing compound metabolic process) AnnotationAssertion(Annotation( "GOC:jl") Annotation( "GOC:mah") "The chemical reactions and pathways involving compounds that contain an indole (2,3-benzopyrrole) skeleton.") -AnnotationAssertion( "GO:0042434") AnnotationAssertion( "indole and derivative metabolic process") AnnotationAssertion( "indole and derivative metabolism") AnnotationAssertion( "indole-containing compound metabolism") @@ -54520,7 +53386,6 @@ SubClassOf( (melatonin catabolic process) AnnotationAssertion(Annotation( "GOC:jl") "The chemical reactions and pathways resulting in the breakdown of melatonin (N-acetyl-5-methoxytryptamine).") -AnnotationAssertion( "GO:0042449") AnnotationAssertion( "melatonin breakdown") AnnotationAssertion( "melatonin catabolism") AnnotationAssertion( "melatonin degradation") @@ -54535,7 +53400,6 @@ SubClassOf( "GOC:jl") "The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/23965"^^xsd:anyURI) AnnotationAssertion( ) -AnnotationAssertion( "GO:0034754") AnnotationAssertion( "hormone metabolism") AnnotationAssertion( "biological_process") AnnotationAssertion( "cellular hormone metabolic process") @@ -54583,7 +53447,6 @@ EquivalentClasses( ObjectIntersection # Class: (photoreceptor cell development) AnnotationAssertion(Annotation( "GOC:go_curators") "Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light.") -AnnotationAssertion( "GO:0046531") AnnotationAssertion( "photoreceptor morphogenesis") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0042461") @@ -54685,7 +53548,6 @@ SubClassOf( ObjectAllValuesFrom( "GOC:jl") Annotation( "GOC:mah") "The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food.") AnnotationAssertion( ) -AnnotationAssertion( "GO:0042477") AnnotationAssertion( "Wikipedia:Odontogenesis") AnnotationAssertion( "odontogeny") AnnotationAssertion( "odontosis") @@ -54742,7 +53604,6 @@ EquivalentClasses( ObjectIntersection # Class: (regulation of odontogenesis) AnnotationAssertion(Annotation( "GOC:jl") "Any process that modulates the frequency, rate or extent of the formation and development of a tooth or teeth.") -AnnotationAssertion( "GO:0042484") AnnotationAssertion( "regulation of tooth development") AnnotationAssertion( "regulation of odontogenesis of calcareous or chitinous tooth") AnnotationAssertion( "biological_process") @@ -54753,7 +53614,6 @@ EquivalentClasses( ObjectIntersection # Class: (positive regulation of odontogenesis) AnnotationAssertion(Annotation( "GOC:jl") "Any process that activates or increases the frequency, rate or extent of the formation and development of a tooth or teeth.") -AnnotationAssertion( "GO:0042485") AnnotationAssertion( "positive regulation of tooth development") AnnotationAssertion( "up regulation of odontogenesis") AnnotationAssertion( "up-regulation of odontogenesis") @@ -54769,7 +53629,6 @@ EquivalentClasses( ObjectIntersection # Class: (negative regulation of odontogenesis) AnnotationAssertion(Annotation( "GOC:jl") "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation and development of a tooth or teeth.") -AnnotationAssertion( "GO:0042486") AnnotationAssertion( "down regulation of odontogenesis") AnnotationAssertion( "down-regulation of odontogenesis") AnnotationAssertion( "downregulation of odontogenesis") @@ -54967,9 +53826,6 @@ SubClassOf( (homeostatic process) AnnotationAssertion(Annotation( "GOC:jl") Annotation( "ISBN:0395825172") "Any biological process involved in the maintenance of an internal steady state.") -AnnotationAssertion( "GO:0032844") -AnnotationAssertion( "GO:0032845") -AnnotationAssertion( "GO:0032846") AnnotationAssertion( "homeostasis") AnnotationAssertion( "activation of homeostatic process") AnnotationAssertion( "inhibition of homeostatic process") @@ -55116,7 +53972,6 @@ SubClassOf( (compound eye cone cell differentiation) AnnotationAssertion(Annotation( "GOC:mtg_sensu") "The process in which a relatively unspecialized cell acquires the specialized features of a compound eye cone cell, a cone-shaped cell, that focuses light in a compound eye.") -AnnotationAssertion( "GO:0042674") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0042675") AnnotationAssertion(rdfs:label "compound eye cone cell differentiation") @@ -55224,8 +54079,6 @@ SubClassOf( ObjectSomeValuesFrom( (defense response to bacterium) AnnotationAssertion(Annotation( "GOC:jl") "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.") -AnnotationAssertion( "GO:0009816") -AnnotationAssertion( "GO:0042830") AnnotationAssertion( "defence response to bacteria") AnnotationAssertion( "defence response to bacterium") AnnotationAssertion( "defense response to bacteria") @@ -55258,17 +54111,6 @@ AnnotationAssertion(rdfs:label "amid EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) -# Class: (nuclear receptor-mediated glucocorticoid signaling pathway) - -AnnotationAssertion(Annotation( "GOC:mah") "A nuclear receptor-mediated signaling pathway initiated by a glucocorticoid binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.") -AnnotationAssertion( "glucocorticoid receptor signaling pathway") -AnnotationAssertion( "glucocorticoid receptor signalling pathway") -AnnotationAssertion( "intracellular glucocorticoid receptor signaling pathway") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "GO:0042921") -AnnotationAssertion(rdfs:label "nuclear receptor-mediated glucocorticoid signaling pathway") -SubClassOf( ) - # Class: (neuropeptide binding) AnnotationAssertion(Annotation( "PMID:10414961") Annotation( "PMID:38337033") "Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators).") @@ -55397,8 +54239,6 @@ SubClassOf( ObjectAllValuesFrom( "GOC:go_curators") Annotation( "GOC:mtg_sensu") "The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.") AnnotationAssertion( ) -AnnotationAssertion( "GO:0001747") -AnnotationAssertion( "GO:0031075") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0043010") AnnotationAssertion(rdfs:label "camera-type eye development") @@ -55434,7 +54274,6 @@ EquivalentClasses( ObjectIntersection # Class: (ribosome binding) AnnotationAssertion(Annotation( "GOC:go_curators") "Binding to a ribosome.") -AnnotationAssertion( "GO:0030376") AnnotationAssertion( "ribosome receptor activity") AnnotationAssertion( "molecular_function") AnnotationAssertion( "GO:0043022") @@ -55563,7 +54402,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:jl") Annotation( "GOC:mtg_apoptosis") "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.") AnnotationAssertion( ) -AnnotationAssertion( "GO:0006916") AnnotationAssertion( "anti-apoptosis") AnnotationAssertion( "down regulation of apoptosis") AnnotationAssertion( "down-regulation of apoptosis") @@ -55584,7 +54422,6 @@ DisjointClasses( ObjectSomeValuesFrom # Class: (regulation of programmed cell death) AnnotationAssertion(Annotation( "GOC:jl") "Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.") -AnnotationAssertion( "GO:0043070") AnnotationAssertion( "regulation of non-apoptotic programmed cell death") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0043067") @@ -55594,7 +54431,6 @@ EquivalentClasses( ObjectIntersection # Class: (positive regulation of programmed cell death) AnnotationAssertion(Annotation( "GOC:jl") "Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.") -AnnotationAssertion( "GO:0043071") AnnotationAssertion( "up regulation of programmed cell death") AnnotationAssertion( "up-regulation of programmed cell death") AnnotationAssertion( "upregulation of programmed cell death") @@ -55609,7 +54445,6 @@ EquivalentClasses( ObjectIntersection # Class: (negative regulation of programmed cell death) AnnotationAssertion(Annotation( "GOC:jl") "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.") -AnnotationAssertion( "GO:0043072") AnnotationAssertion( "down regulation of programmed cell death") AnnotationAssertion( "down-regulation of programmed cell death") AnnotationAssertion( "downregulation of programmed cell death") @@ -55633,7 +54468,6 @@ SubClassOf( (positive regulation of catalytic activity) AnnotationAssertion(Annotation( "GOC:ebc") Annotation( "GOC:jl") Annotation( "GOC:tb") Annotation( "GOC:vw") "Any process that activates or increases the activity of an enzyme.") -AnnotationAssertion( "GO:0048554") AnnotationAssertion(Annotation( "GOC:tb") "positive regulation of enzyme activity") AnnotationAssertion( "up regulation of enzyme activity") AnnotationAssertion( "up-regulation of enzyme activity") @@ -55656,7 +54490,6 @@ EquivalentClasses( ObjectIntersection # Class: (negative regulation of catalytic activity) AnnotationAssertion(Annotation( "GOC:ebc") Annotation( "GOC:jl") Annotation( "GOC:tb") Annotation( "GOC:vw") "Any process that stops or reduces the activity of an enzyme.") -AnnotationAssertion( "GO:0048553") AnnotationAssertion( "down regulation of enzyme activity") AnnotationAssertion( "down-regulation of enzyme activity") AnnotationAssertion( "down-regulation of metalloenzyme activity") @@ -55711,7 +54544,6 @@ SubClassOf( "PMID:23708874") Annotation( "PMID:9751757") "Any process involved in the maintenance of a steady-state level of a surface-active agent that maintains the surface tension of a liquid.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/24222"^^xsd:anyURI) -AnnotationAssertion( "GO:0050828") AnnotationAssertion( "biological_process") AnnotationAssertion( "regulation of liquid surface tension") AnnotationAssertion( "regulation of surface tension of a liquid") @@ -55768,9 +54600,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:mah") "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/26424"^^xsd:anyURI) -AnnotationAssertion( "GO:0034960") -AnnotationAssertion( "GO:0043283") -AnnotationAssertion( "GO:0044259") AnnotationAssertion(Annotation( "GOC:mtg_chebi_dec09") "biopolymer metabolic process") AnnotationAssertion( "macromolecule metabolism") AnnotationAssertion( "organismal macromolecule metabolism") @@ -55845,7 +54674,6 @@ SubClassOf( ObjectSomeValuesFrom( (response to amino acid) AnnotationAssertion(Annotation( "GOC:ef") Annotation( "GOC:mlg") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.") -AnnotationAssertion( "GO:0010237") AnnotationAssertion(Annotation( "GOC:dos") "response to amino acid stimulus") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0043200") @@ -55917,19 +54745,22 @@ EquivalentClasses( ObjectIntersection SubClassOf( ) DisjointClasses( ) -# Class: (non-membrane-bounded organelle) +# Class: (membraneless organelle) AnnotationAssertion(Annotation( "GOC:go_curators") "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/21881"^^xsd:anyURI) AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/28153"^^xsd:anyURI) +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/29106"^^xsd:anyURI) AnnotationAssertion( "NIF_Subcellular:sao1456184038") +AnnotationAssertion( "membrane-less organelle") +AnnotationAssertion( "non-membrane-bounded organelle") AnnotationAssertion( "non-membrane-enclosed organelle") AnnotationAssertion( "cellular_component") AnnotationAssertion( "biological condensate") AnnotationAssertion( "GO:0043228") AnnotationAssertion( ) AnnotationAssertion( ) -AnnotationAssertion(rdfs:label "non-membrane-bounded organelle") +AnnotationAssertion(rdfs:label "membraneless organelle") SubClassOf( ) # Class: (intracellular organelle) @@ -55966,14 +54797,16 @@ AnnotationAssertion(rdfs:label "intr EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) -# Class: (intracellular non-membrane-bounded organelle) +# Class: (intracellular membraneless organelle) AnnotationAssertion(Annotation( "GOC:go_curators") "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.") +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/29106"^^xsd:anyURI) +AnnotationAssertion( "intracellular non-membrane-bounded organelle") AnnotationAssertion( "intracellular non-membrane-enclosed organelle") AnnotationAssertion( "cellular_component") AnnotationAssertion( "GO:0043232") AnnotationAssertion( ) -AnnotationAssertion(rdfs:label "intracellular non-membrane-bounded organelle") +AnnotationAssertion(rdfs:label "intracellular membraneless organelle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (organelle lumen) @@ -56066,13 +54899,15 @@ EquivalentClasses( ObjectIntersection SubClassOf( ) SubClassOf( ) -# Class: (extracellular non-membrane-bounded organelle) +# Class: (extracellular membraneless organelle) AnnotationAssertion(Annotation( "GOC:jl") "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring outside the cell.") +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/29106"^^xsd:anyURI) +AnnotationAssertion( "extracellular non-membrane-bounded organelle") AnnotationAssertion( "extracellular non-membrane-enclosed organelle") AnnotationAssertion( "cellular_component") AnnotationAssertion( "GO:0043264") -AnnotationAssertion(rdfs:label "extracellular non-membrane-bounded organelle") +AnnotationAssertion(rdfs:label "extracellular membraneless organelle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (regulation of potassium ion transport) @@ -56901,27 +55736,6 @@ AnnotationAssertion( "proteoglycan binding") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -# Class: (steroid hormone receptor signaling pathway) - -AnnotationAssertion(Annotation( "PMID:12606724") "The series of molecular signals mediated by a steroid hormone binding to a receptor.") -AnnotationAssertion( "steroid hormone mediated signalling") -AnnotationAssertion( "steroid hormone-mediated signaling pathway") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "GO:0043401") -AnnotationAssertion(rdfs:label "steroid hormone receptor signaling pathway") -SubClassOf( ) -SubClassOf( ObjectSomeValuesFrom( )) - -# Class: (glucocorticoid mediated signaling pathway) - -AnnotationAssertion(Annotation( "PMID:15240347") "The series of molecular signals mediated by the detection of a glucocorticoid hormone.") -AnnotationAssertion( "glucocorticoid mediated signalling") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "GO:0043402") -AnnotationAssertion(rdfs:label "glucocorticoid mediated signaling pathway") -SubClassOf( ) -SubClassOf( ObjectSomeValuesFrom( )) - # Class: (skeletal muscle tissue regeneration) AnnotationAssertion(Annotation( "GOC:ef") Annotation( "GOC:mtg_muscle") Annotation( "PMID:12021255") Annotation( "PMID:16607119") "The regrowth of skeletal muscle tissue to repair injured or damaged muscle fibers in the postnatal stage.") @@ -56979,27 +55793,6 @@ AnnotationAssertion(rdfs:label "nega EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) -# Class: (negative regulation of DNA-binding transcription factor activity) - -AnnotationAssertion(Annotation( "GOC:jl") "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.") -AnnotationAssertion( "2011-07-15T10:56:12Z") -AnnotationAssertion( "GO:1904168") -AnnotationAssertion( "GO:2000824") -AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "negative regulation of transcription factor activity") -AnnotationAssertion( "down regulation of transcription factor activity") -AnnotationAssertion( "down-regulation of transcription factor activity") -AnnotationAssertion( "downregulation of transcription factor activity") -AnnotationAssertion( "negative regulation of DNA binding transcription factor activity") -AnnotationAssertion( "negative regulation of sequence-specific DNA binding transcription factor activity") -AnnotationAssertion( "inhibition of transcription factor activity") -AnnotationAssertion( "negative regulation of androgen receptor activity") -AnnotationAssertion( "negative regulation of thyroid hormone receptor activity") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "GO:0043433") -AnnotationAssertion( ) -AnnotationAssertion(rdfs:label "negative regulation of DNA-binding transcription factor activity") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) - # Class: (response to peptide hormone) AnnotationAssertion(Annotation( "PMID:11027914") Annotation( "PMID:15134857") Annotation( "Wikipedia:Peptide_hormone") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.") @@ -57055,7 +55848,7 @@ AnnotationAssertion( "GO:0043467") AnnotationAssertion(rdfs:label "regulation of generation of precursor metabolites and energy") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) +SubClassOf( ) # Class: (regulation of carbohydrate catabolic process) @@ -57237,15 +56030,6 @@ SubClassOf( ObjectComplementOf(Object SubClassOf( ObjectSomeValuesFrom( ObjectComplementOf())) DisjointClasses( ObjectSomeValuesFrom( )) -# Class: (sequence-specific DNA binding) - -AnnotationAssertion(Annotation( "GOC:jl") "Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.") -AnnotationAssertion( "sequence specific DNA binding") -AnnotationAssertion( "molecular_function") -AnnotationAssertion( "GO:0043565") -AnnotationAssertion(rdfs:label "sequence-specific DNA binding") -SubClassOf( ) - # Class: (regulation of respiratory gaseous exchange) AnnotationAssertion(Annotation( "GOC:jl") "Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment.") @@ -57481,9 +56265,6 @@ AnnotationAssertion(Annotation( "https://github.com/geneontology/go-ontology/issues/22580"^^xsd:anyURI) AnnotationAssertion( "mah") AnnotationAssertion( "2010-09-08T10:01:42Z") -AnnotationAssertion( "GO:0034600") -AnnotationAssertion( "GO:0034621") -AnnotationAssertion( "GO:0071822") AnnotationAssertion(Annotation( "GOC:mah") "protein complex subunit organisation") AnnotationAssertion( "protein complex subunit organization") AnnotationAssertion( "biological_process") @@ -57628,7 +56409,6 @@ SubClassOf( "GOC:jl") Annotation( "GOC:mah") "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/27194"^^xsd:anyURI) -AnnotationAssertion( "GO:0071843") AnnotationAssertion( "cellular component biogenesis at cellular level") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0044085") @@ -57719,18 +56499,18 @@ AnnotationAssertion(rdfs:label "tran SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) -# Class: (cellular metabolic process) +# Class: (obsolete cellular metabolic process) -AnnotationAssertion(Annotation( "GOC:go_curators") "The chemical reactions and pathways by which individual cells transform chemical substances.") +AnnotationAssertion(Annotation( "GOC:go_curators") "OBSOLETE. The chemical reactions and pathways by which individual cells transform chemical substances.") +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/29021"^^xsd:anyURI) +AnnotationAssertion( "GO:0008152") AnnotationAssertion( "cellular metabolism") AnnotationAssertion( "biological_process") AnnotationAssertion(Annotation( "GOC:mah") "intermediary metabolism") AnnotationAssertion( "GO:0044237") -AnnotationAssertion( ) -AnnotationAssertion(rdfs:comment "This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term.") -AnnotationAssertion(rdfs:label "cellular metabolic process") -SubClassOf( ) -SubClassOf( ) +AnnotationAssertion(rdfs:comment "The reason for obsoletion is that this term is now redundant with GO:0008152, metabolic process") +AnnotationAssertion(rdfs:label "obsolete cellular metabolic process") +AnnotationAssertion(owl:deprecated "true"^^xsd:boolean) # Class: (primary metabolic process) @@ -57748,19 +56528,6 @@ AnnotationAssertion( "primary metabolic process") SubClassOf( ) -# Class: (cellular lipid catabolic process) - -AnnotationAssertion(Annotation( "GOC:jl") "The chemical reactions and pathways resulting in the breakdown of lipids, as carried out by individual cells.") -AnnotationAssertion( "cellular lipid breakdown") -AnnotationAssertion( "cellular lipid catabolism") -AnnotationAssertion( "cellular lipid degradation") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "GO:0044242") -AnnotationAssertion(rdfs:label "cellular lipid catabolic process") -SubClassOf( ) -SubClassOf( ) -SubClassOf( ) - # Class: (cellular catabolic process) AnnotationAssertion(Annotation( "GOC:jl") "The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.") @@ -57770,35 +56537,8 @@ AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0044248") AnnotationAssertion(rdfs:label "cellular catabolic process") +SubClassOf( ) SubClassOf( ) -SubClassOf( ) - -# Class: (cellular biosynthetic process) - -AnnotationAssertion(Annotation( "GOC:jl") "The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.") -AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/27052"^^xsd:anyURI) -AnnotationAssertion( "cellular anabolism") -AnnotationAssertion( "cellular biosynthesis") -AnnotationAssertion( "cellular formation") -AnnotationAssertion( "cellular synthesis") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "GO:0044249") -AnnotationAssertion( ) -AnnotationAssertion(rdfs:comment "This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term.") -AnnotationAssertion(rdfs:label "cellular biosynthetic process") -SubClassOf( ) -SubClassOf( ) - -# Class: (cellular lipid metabolic process) - -AnnotationAssertion(Annotation( "GOC:jl") "The chemical reactions and pathways involving lipids, as carried out by individual cells.") -AnnotationAssertion( "cellular lipid metabolism") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "GO:0044255") -AnnotationAssertion( ) -AnnotationAssertion(rdfs:label "cellular lipid metabolic process") -SubClassOf( ) -SubClassOf( ) # Class: (intestinal lipid catabolic process) @@ -57961,7 +56701,6 @@ DisjointClasses( ObjectSomeValuesFrom AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:cilia") Annotation( "GOC:krc") Annotation( "GO_REF:0000079") Annotation( "PMID:19776033") Annotation( "PMID:21129373") Annotation( "ZFIN:dsf") "The aggregation, arrangement and bonding together of a set of components to form a motile cilium.") AnnotationAssertion( "krc") AnnotationAssertion( "2015-02-06T17:23:23Z") -AnnotationAssertion( "GO:1903887") AnnotationAssertion( "biological_process") AnnotationAssertion(Annotation( "GOC:TermGenie") "motile primary cilia assembly") AnnotationAssertion(Annotation( "GOC:TermGenie") "motile primary cilia formation") @@ -58098,7 +56837,6 @@ SubClassOf( "GOC:jl") "Binding to a macromolecular complex.") AnnotationAssertion( "jl") AnnotationAssertion( "2014-12-16T11:38:58Z") -AnnotationAssertion( "GO:0032403") AnnotationAssertion( "protein complex binding") AnnotationAssertion( "molecular_function") AnnotationAssertion( "macromolecular complex binding") @@ -58134,7 +56872,6 @@ EquivalentClasses( ObjectIntersection # Class: (plasma membrane fusion) AnnotationAssertion(Annotation( "GOC:elh") Annotation( "GOC:mtg_muscle") "The joining of the lipid bilayer membrane that surround a cell with that of another cell, producing a single cell.") -AnnotationAssertion( "GO:0006947") AnnotationAssertion( "cell fusion") AnnotationAssertion( "cell-cell fusion") AnnotationAssertion( "biological_process") @@ -58238,7 +56975,6 @@ AnnotationAssertion(Annotation( ) AnnotationAssertion( ) AnnotationAssertion( ) -AnnotationAssertion( "GO:0002226") AnnotationAssertion( "Wikipedia:Innate_immune_system") AnnotationAssertion(Annotation( "GOC:pg") "innate immunity") AnnotationAssertion( "nonspecific immune response") @@ -58463,8 +57199,6 @@ SubClassOf( ObjectSomeValuesFrom( (establishment or maintenance of neuroblast polarity) AnnotationAssertion(Annotation( "GOC:bf") Annotation( "GOC:mah") Annotation( "GOC:mtg_sensu") Annotation( "PMID:19375318") Annotation( "PMID:20066083") "Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system.") -AnnotationAssertion( "GO:0043339") -AnnotationAssertion( "GO:0043342") AnnotationAssertion( "establishment and/or maintenance of neuroblast cell polarity") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0045196") @@ -58475,8 +57209,6 @@ SubClassOf( ObjectSomeValuesFrom( (establishment of neuroblast polarity) AnnotationAssertion(Annotation( "GOC:bf") Annotation( "GOC:mtg_sensu") "The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system.") -AnnotationAssertion( "GO:0043340") -AnnotationAssertion( "GO:0043343") AnnotationAssertion( "establishment of neuroblast cell polarity") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0045200") @@ -58521,7 +57253,6 @@ SubClassOf( ObjectSomeValuesFrom( (sarcomere organization) AnnotationAssertion(Annotation( "GOC:bf") "The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.") -AnnotationAssertion( "GO:0006938") AnnotationAssertion( "sarcomere alignment") AnnotationAssertion( "sarcomere organisation") AnnotationAssertion( "biological_process") @@ -60398,7 +59129,7 @@ AnnotationAssertion( "GO:0045721") AnnotationAssertion(rdfs:label "negative regulation of gluconeogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) +SubClassOf( ) SubClassOf( ) # Class: (positive regulation of gluconeogenesis) @@ -60413,7 +59144,7 @@ AnnotationAssertion( "GO:0045722") AnnotationAssertion(rdfs:label "positive regulation of gluconeogenesis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) +SubClassOf( ) # Class: (positive regulation of cilium assembly) @@ -60447,14 +59178,13 @@ AnnotationAssertion( "positive regulation of glycogen biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +SubClassOf( ) SubClassOf( ) -SubClassOf( ) SubClassOf( ) # Class: (positive regulation of translation) AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:go_curators") Annotation( "GOC:tb") "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.") -AnnotationAssertion( "GO:0045946") AnnotationAssertion( "positive regulation of protein anabolism") AnnotationAssertion( "positive regulation of protein biosynthesis") AnnotationAssertion(Annotation( "GOC:tb") "positive regulation of protein biosynthetic process") @@ -60497,8 +59227,6 @@ SubClassOf( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/23112"^^xsd:anyURI) -AnnotationAssertion( "GO:1903364") -AnnotationAssertion( "GO:2000600") AnnotationAssertion(Annotation( "GOC:TermGenie") "positive regulation of cellular protein breakdown") AnnotationAssertion( "positive regulation of cellular protein catabolic process") AnnotationAssertion(Annotation( "GOC:TermGenie") "positive regulation of cellular protein catabolism") @@ -60604,9 +59332,10 @@ AnnotationAssertion(rdfs:label "posi EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) -# Class: (negative regulation of cellular amino acid metabolic process) +# Class: (negative regulation of amino acid metabolic process) AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amino acid.") +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/28908"^^xsd:anyURI) AnnotationAssertion( "down regulation of amino acid metabolic process") AnnotationAssertion( "down-regulation of amino acid metabolic process") AnnotationAssertion( "downregulation of amino acid metabolic process") @@ -60614,10 +59343,9 @@ AnnotationAssertion( "inhibition of amino acid metabolic process") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0045763") -AnnotationAssertion(rdfs:label "negative regulation of cellular amino acid metabolic process") +AnnotationAssertion(rdfs:label "negative regulation of amino acid metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) -SubClassOf( ) # Class: (positive regulation of amino acid metabolic process) @@ -60634,7 +59362,6 @@ AnnotationAssertion( "positive regulation of amino acid metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) -SubClassOf( ) # Class: (regulation of angiogenesis) @@ -60805,6 +59532,7 @@ SubClassOf( (negative regulation of glycogen catabolic process) AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen.") +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/29024"^^xsd:anyURI) AnnotationAssertion( "down regulation of glycogen catabolic process") AnnotationAssertion( "down-regulation of glycogen catabolic process") AnnotationAssertion( "downregulation of glycogen catabolic process") @@ -60818,12 +59546,13 @@ AnnotationAssertion( "negative regulation of glycogen catabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) -SubClassOf( ) +SubClassOf( ) SubClassOf( ) # Class: (positive regulation of glycogen catabolic process) AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen.") +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/29024"^^xsd:anyURI) AnnotationAssertion( "positive regulation of glycogen breakdown") AnnotationAssertion( "positive regulation of glycogen catabolism") AnnotationAssertion( "positive regulation of glycogen degradation") @@ -60838,7 +59567,7 @@ AnnotationAssertion( "positive regulation of glycogen catabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) -SubClassOf( ) +SubClassOf( ) SubClassOf( ) # Class: (negative regulation of heart contraction) @@ -61139,56 +59868,6 @@ AnnotationAssertion( "positive regulation of sporulation resulting in formation of a cellular spore") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -# Class: (negative regulation of DNA-templated transcription) - -AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "GOC:txnOH") "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.") -AnnotationAssertion( "GO:0016481") -AnnotationAssertion( "GO:0032582") -AnnotationAssertion( "GO:0061021") -AnnotationAssertion( "down regulation of transcription, DNA-dependent") -AnnotationAssertion( "down-regulation of transcription, DNA-dependent") -AnnotationAssertion( "downregulation of transcription, DNA-dependent") -AnnotationAssertion( "negative regulation of cellular transcription, DNA-dependent") -AnnotationAssertion(Annotation( "GOC:txnOH") "negative regulation of transcription, DNA-dependent") -AnnotationAssertion( "negative regulation of transcription, DNA-templated") -AnnotationAssertion( "inhibition of transcription, DNA-dependent") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "down regulation of gene-specific transcription") -AnnotationAssertion( "down-regulation of gene-specific transcription") -AnnotationAssertion( "downregulation of gene-specific transcription") -AnnotationAssertion( "inhibition of gene-specific transcription") -AnnotationAssertion( "negative regulation of gene-specific transcription") -AnnotationAssertion( "transcription repressor activity") -AnnotationAssertion( "GO:0045892") -AnnotationAssertion(rdfs:label "negative regulation of DNA-templated transcription") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) - -# Class: (positive regulation of DNA-templated transcription) - -AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "GOC:txnOH") "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.") -AnnotationAssertion( "GO:0043193") -AnnotationAssertion( "GO:0045941") -AnnotationAssertion( "GO:0061020") -AnnotationAssertion( "positive regulation of cellular transcription, DNA-dependent") -AnnotationAssertion(Annotation( "GOC:txnOH") "positive regulation of transcription, DNA-dependent") -AnnotationAssertion( "positive regulation of transcription, DNA-templated") -AnnotationAssertion( "up regulation of transcription, DNA-dependent") -AnnotationAssertion( "up-regulation of transcription, DNA-dependent") -AnnotationAssertion( "upregulation of transcription, DNA-dependent") -AnnotationAssertion( "activation of transcription, DNA-dependent") -AnnotationAssertion( "stimulation of gene-specific transcription") -AnnotationAssertion( "stimulation of transcription, DNA-dependent") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "activation of gene-specific transcription") -AnnotationAssertion( "positive regulation of gene-specific transcription") -AnnotationAssertion( "transcription activator activity") -AnnotationAssertion( "up regulation of gene-specific transcription") -AnnotationAssertion( "up-regulation of gene-specific transcription") -AnnotationAssertion( "upregulation of gene-specific transcription") -AnnotationAssertion( "GO:0045893") -AnnotationAssertion(rdfs:label "positive regulation of DNA-templated transcription") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) - # Class: (negative regulation of translational elongation) AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation.") @@ -61560,31 +60239,6 @@ EquivalentClasses( ObjectIntersection SubClassOf( ) SubClassOf( ) -# Class: (positive regulation of transcription by RNA polymerase II) - -AnnotationAssertion(Annotation( "GOC:go_curators") Annotation( "GOC:txnOH") "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.") -AnnotationAssertion( "GO:0010552") -AnnotationAssertion( "GO:0045817") -AnnotationAssertion( "activation of transcription from RNA polymerase II promoter") -AnnotationAssertion( "positive regulation of transcription from Pol II promoter") -AnnotationAssertion( "positive regulation of transcription from RNA polymerase II promoter") -AnnotationAssertion( "stimulation of transcription from RNA polymerase II promoter") -AnnotationAssertion( "up regulation of transcription from RNA polymerase II promoter") -AnnotationAssertion( "up-regulation of transcription from RNA polymerase II promoter") -AnnotationAssertion( "upregulation of transcription from RNA polymerase II promoter") -AnnotationAssertion( "stimulation of global transcription from RNA polymerase II promoter") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "activation of global transcription from RNA polymerase II promoter") -AnnotationAssertion( "positive regulation of gene-specific transcription from RNA polymerase II promoter") -AnnotationAssertion( "positive regulation of global transcription from Pol II promoter") -AnnotationAssertion( "positive regulation of transcription from RNA polymerase II promoter, global") -AnnotationAssertion( "up regulation of global transcription from RNA polymerase II promoter") -AnnotationAssertion( "up-regulation of global transcription from RNA polymerase II promoter") -AnnotationAssertion( "upregulation of global transcription from RNA polymerase II promoter") -AnnotationAssertion( "GO:0045944") -AnnotationAssertion(rdfs:label "positive regulation of transcription by RNA polymerase II") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) - # Class: (negative regulation of translational initiation) AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation.") @@ -62019,7 +60673,6 @@ AnnotationAssertion(rdfs:label "alde EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) SubClassOf( ) -SubClassOf( ) # Class: (aldehyde catabolic process) @@ -62031,7 +60684,6 @@ AnnotationAssertion( "GO:0046185") AnnotationAssertion(rdfs:label "aldehyde catabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) # Class: (phenol-containing compound biosynthetic process) @@ -62105,6 +60757,45 @@ AnnotationAssertion(rdfs:label "carb EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (short-chain fatty acid metabolic process) + +AnnotationAssertion(Annotation( "Wikipedia:Fatty_acid_metabolism") "The chemical reactions and pathways involving a short-chain fatty acid. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons.") +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/26445"^^xsd:anyURI) +AnnotationAssertion( "short-chain fatty acid metabolism") +AnnotationAssertion( "biological_process") +AnnotationAssertion( "GO:0046459") +AnnotationAssertion(rdfs:comment "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).") +AnnotationAssertion(rdfs:label "short-chain fatty acid metabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + +# Class: (membrane lipid catabolic process) + +AnnotationAssertion(Annotation( "GOC:ai") "The chemical reactions and pathways resulting in the breakdown of membrane lipids, any lipid found in or associated with a biological membrane.") +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/28908"^^xsd:anyURI) +AnnotationAssertion(Annotation( "GOC:tb") "membrane lipid peroxidation") +AnnotationAssertion( "membrane lipid breakdown") +AnnotationAssertion( "membrane lipid catabolism") +AnnotationAssertion( "membrane lipid degradation") +AnnotationAssertion( "biological_process") +AnnotationAssertion( "GO:0046466") +AnnotationAssertion(rdfs:label "membrane lipid catabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ) + +# Class: (membrane lipid biosynthetic process) + +AnnotationAssertion(Annotation( "GOC:ai") "The chemical reactions and pathways resulting in the formation of membrane lipids, any lipid found in or associated with a biological membrane.") +AnnotationAssertion( "membrane lipid anabolism") +AnnotationAssertion( "membrane lipid biosynthesis") +AnnotationAssertion( "membrane lipid formation") +AnnotationAssertion( "membrane lipid synthesis") +AnnotationAssertion( "biological_process") +AnnotationAssertion( "GO:0046467") +AnnotationAssertion(rdfs:label "membrane lipid biosynthetic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ) + # Class: (glycosphingolipid catabolic process) AnnotationAssertion(Annotation( "ISBN:0198506732") "The chemical reactions and pathways resulting in the breakdown of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide.") @@ -62119,7 +60810,6 @@ EquivalentClasses( ObjectIntersection # Class: (photoreceptor cell differentiation) AnnotationAssertion(Annotation( "GOC:ai") Annotation( "ISBN:0198506732") "The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster.") -AnnotationAssertion( "GO:0007467") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0046530") AnnotationAssertion(rdfs:label "photoreceptor cell differentiation") @@ -62129,7 +60819,6 @@ SubClassOf( (regulation of photoreceptor cell differentiation) AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster.") -AnnotationAssertion( "GO:0045673") AnnotationAssertion( "regulation of photoreceptor differentiation") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0046532") @@ -62139,7 +60828,6 @@ EquivalentClasses( ObjectIntersection # Class: (negative regulation of photoreceptor cell differentiation) AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that stops, prevents, or reduces the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster.") -AnnotationAssertion( "GO:0045674") AnnotationAssertion( "down regulation of photoreceptor cell differentiation") AnnotationAssertion( "down regulation of photoreceptor differentiation") AnnotationAssertion( "down-regulation of photoreceptor cell differentiation") @@ -62158,7 +60846,6 @@ SubClassOf( (positive regulation of photoreceptor cell differentiation) AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that activates or increases the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster.") -AnnotationAssertion( "GO:0045675") AnnotationAssertion( "positive regulation of photoreceptor differentiation") AnnotationAssertion( "up regulation of photoreceptor cell differentiation") AnnotationAssertion( "up regulation of photoreceptor differentiation") @@ -63042,7 +61729,7 @@ AnnotationAssertion( "GO:0046885") AnnotationAssertion(rdfs:label "regulation of hormone biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) +SubClassOf( ) SubClassOf( ) # Class: (positive regulation of hormone biosynthetic process) @@ -63061,7 +61748,7 @@ AnnotationAssertion( "GO:0046886") AnnotationAssertion(rdfs:label "positive regulation of hormone biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) +SubClassOf( ) SubClassOf( ) SubClassOf( ) @@ -63148,7 +61835,6 @@ SubClassOf( "GOC:ai") "The directed movement of substances within a cell.") AnnotationAssertion( "jl") AnnotationAssertion( "2013-12-18T14:04:50Z") -AnnotationAssertion( "GO:1902582") AnnotationAssertion( "biological_process") AnnotationAssertion(Annotation( "GOC:TermGenie") "single organism intracellular transport") AnnotationAssertion( "single-organism intracellular transport") @@ -63318,7 +62004,6 @@ EquivalentClasses( ObjectIntersection # Class: (female germ-line stem cell asymmetric division) AnnotationAssertion(Annotation( "GOC:jid") Annotation( "GOC:mtg_sensu") "The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes.") -AnnotationAssertion( "GO:0048141") AnnotationAssertion( "female germ-line stem cell renewal") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0048132") @@ -63864,8 +62549,6 @@ SubClassOf( ObjectSomeValuesFrom( (oogenesis) AnnotationAssertion(Annotation( "GOC:kmv") Annotation( "GOC:mtg_sensu") Annotation( "GOC:pr") "The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.") -AnnotationAssertion( "GO:0009993") -AnnotationAssertion( "GO:0048157") AnnotationAssertion( "Wikipedia:Oogenesis") AnnotationAssertion(Annotation( ) "ovum development") AnnotationAssertion( "biological_process") @@ -63980,7 +62663,6 @@ SubClassOf( ObjectSomeValuesFrom( (positive regulation of biological process) AnnotationAssertion(Annotation( "GOC:jid") "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.") -AnnotationAssertion( "GO:0043119") AnnotationAssertion( "positive regulation of physiological process") AnnotationAssertion( "up regulation of biological process") AnnotationAssertion( "up-regulation of biological process") @@ -63997,7 +62679,6 @@ SubClassOf( (negative regulation of biological process) AnnotationAssertion(Annotation( "GOC:jid") "Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.") -AnnotationAssertion( "GO:0043118") AnnotationAssertion( "down regulation of biological process") AnnotationAssertion( "down-regulation of biological process") AnnotationAssertion( "downregulation of biological process") @@ -64042,7 +62723,6 @@ SubClassOf( (positive regulation of cellular process) AnnotationAssertion(Annotation( "GOC:jid") "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.") -AnnotationAssertion( "GO:0051242") AnnotationAssertion( "positive regulation of cellular physiological process") AnnotationAssertion( "up regulation of cellular process") AnnotationAssertion( "up-regulation of cellular process") @@ -64058,7 +62738,6 @@ EquivalentClasses( ObjectIntersection # Class: (negative regulation of cellular process) AnnotationAssertion(Annotation( "GOC:jid") "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.") -AnnotationAssertion( "GO:0051243") AnnotationAssertion( "down regulation of cellular process") AnnotationAssertion( "down-regulation of cellular process") AnnotationAssertion( "downregulation of cellular process") @@ -64180,7 +62859,6 @@ SubClassOf( (digestive tract morphogenesis) AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:go_curators") Annotation( "PMID:12618131") "The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed.") -AnnotationAssertion( "GO:0048547") AnnotationAssertion(Annotation( "GOC:dph") "gut morphogenesis") AnnotationAssertion( "alimentary canal morphogenesis") AnnotationAssertion( "digestive tube morphogenesis") @@ -64348,7 +63026,6 @@ EquivalentClasses( ObjectIntersection # Class: (eye morphogenesis) AnnotationAssertion(Annotation( "GOC:jid") Annotation( "GOC:mtg_sensu") "The process in which the anatomical structures of the eye are generated and organized.") -AnnotationAssertion( "GO:0048748") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0048592") AnnotationAssertion(rdfs:label "eye morphogenesis") @@ -64359,8 +63036,6 @@ SubClassOf( ObjectSomeValuesFrom( (camera-type eye morphogenesis) AnnotationAssertion(Annotation( "GOC:jid") Annotation( "GOC:mtg_sensu") "The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.") -AnnotationAssertion( "GO:0048594") -AnnotationAssertion( "GO:0048595") AnnotationAssertion(Annotation( "GOC:dph") "camera-style eye morphogenesis") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0048593") @@ -64383,7 +63058,6 @@ SubClassOf( ObjectSomeValuesFrom( (embryonic morphogenesis) AnnotationAssertion(Annotation( "GOC:jid") Annotation( "GOC:mtg_sensu") "The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants.") -AnnotationAssertion( "GO:0048828") AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "embryonic anatomical structure morphogenesis") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0048598") @@ -64983,7 +63657,6 @@ SubClassOf( (compound eye development) AnnotationAssertion(Annotation( "GOC:jid") Annotation( "GOC:mtg_sensu") Annotation( "Wikipedia:Eye") "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye.") -AnnotationAssertion( "GO:0007456") AnnotationAssertion(Annotation( "PMID:11735386") "insect-type retina development") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0048749") @@ -65859,7 +64532,6 @@ SubClassOf( ObjectSomeValuesFrom( (anterior lateral line nerve development) AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") Annotation( "ISBN:0125296509") "The process whose specific outcome is the progression of the anterior lateral line nerve over time, form its formation to the mature structure. The anterior lateral line nerve contains efferent axons that innervate hair cells of the ALL and afferent axons that project to an octavolateralis column in the hindbrain. The octavolateralis column consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus.") -AnnotationAssertion( "GO:0021734") AnnotationAssertion( "ALLN development") AnnotationAssertion( "nALL development") AnnotationAssertion( "rostral lateral line nerve development") @@ -65916,7 +64588,6 @@ SubClassOf( ObjectSomeValuesFrom( (posterior lateral line nerve development) AnnotationAssertion(Annotation( "GOC:cls") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:jid") Annotation( "GO_REF:0000021") Annotation( "ISBN:0125296509") "The process whose specific outcome is the progression of the posterior lateral line nerve over time, from its formation to the mature structure. The posterior lateral line nerve innervates hair cells of the PLL and projects to an octavolateralis column in the hindbrain that consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus.") -AnnotationAssertion( "GO:0021733") AnnotationAssertion( "PLLN development") AnnotationAssertion( "caudal lateral line nerve development") AnnotationAssertion( "biological_process") @@ -66081,28 +64752,6 @@ AnnotationAssertion( "chromosome localization") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -# Class: ([tyrosine 3-monooxygenase] kinase activity) - -AnnotationAssertion(Annotation( "EC:2.7.11.6") Annotation( "MetaCyc:TYROSINE-3-MONOOXYGENASE-KINASE-RXN") "Catalysis of the reaction: ATP + [tyrosine-3-monooxygenase] = ADP + phospho-[tyrosine-3-monooxygenase].") -AnnotationAssertion( "EC:2.7.11.6") -AnnotationAssertion( "MetaCyc:2.7.11.6-RXN") -AnnotationAssertion( "RHEA:17133") -AnnotationAssertion( "tyrosine 3-monooxygenase kinase activity") -AnnotationAssertion( "molecular_function") -AnnotationAssertion(Annotation( "EC:2.7.11.6") "ATP:tyrosine-3-monoxygenase phosphotransferase activity") -AnnotationAssertion(Annotation( "EC:2.7.11.6") "STK4") -AnnotationAssertion(Annotation( "EC:2.7.11.6") "pheochromocytoma tyrosine hydroxylase-associated kinase activity") -AnnotationAssertion(Annotation( "EC:2.7.11.6") "tyrosine 3-monooxygenase kinase (phosphorylating) activity") -AnnotationAssertion( "GO:0050369") -AnnotationAssertion(rdfs:label "[tyrosine 3-monooxygenase] kinase activity") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) -SubClassOf( ObjectSomeValuesFrom( )) -SubClassOf( ObjectSomeValuesFrom( )) -SubClassOf( ObjectSomeValuesFrom( )) -SubClassOf( ObjectSomeValuesFrom( )) -SubClassOf( ObjectSomeValuesFrom( )) - # Class: (catecholamine secretion) AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:ef") "The regulated release of catecholamines by a cell. The catecholamines are a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.") @@ -66349,7 +64998,6 @@ SubClassOf( (negative regulation of inflammatory response) AnnotationAssertion(Annotation( "GOC:ai") "Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.") -AnnotationAssertion( "GO:0030236") AnnotationAssertion( "anti-inflammatory response") AnnotationAssertion( "down regulation of inflammatory response") AnnotationAssertion( "down-regulation of inflammatory response") @@ -66399,6 +65047,7 @@ AnnotationAssertion( "stimulation of peptidyl-tyrosine phosphorylation") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0050731") +AnnotationAssertion( ) AnnotationAssertion(rdfs:label "positive regulation of peptidyl-tyrosine phosphorylation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) @@ -66424,7 +65073,7 @@ AnnotationAssertion( "GO:0050746") AnnotationAssertion(rdfs:label "regulation of lipoprotein metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) +SubClassOf( ) # Class: (positive regulation of lipoprotein metabolic process) @@ -66439,7 +65088,7 @@ AnnotationAssertion( "GO:0050747") AnnotationAssertion(rdfs:label "positive regulation of lipoprotein metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) +SubClassOf( ) # Class: (negative regulation of lipoprotein metabolic process) @@ -66453,7 +65102,7 @@ AnnotationAssertion( "GO:0050748") AnnotationAssertion(rdfs:label "negative regulation of lipoprotein metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) +SubClassOf( ) # Class: (regulation of phagocytosis) @@ -66651,7 +65300,6 @@ SubClassOf( (regulation of biological process) AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.") -AnnotationAssertion( "GO:0050791") AnnotationAssertion( "regulation of physiological process") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0050789") @@ -66665,7 +65313,6 @@ SubClassOf( (regulation of catalytic activity) AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:ebc") Annotation( "GOC:vw") "Any process that modulates the activity of an enzyme.") -AnnotationAssertion( "GO:0048552") AnnotationAssertion( "regulation of enzyme activity") AnnotationAssertion( "regulation of metalloenzyme activity") AnnotationAssertion( "biological_process") @@ -66687,7 +65334,6 @@ SubClassOf( (regulation of cellular process) AnnotationAssertion(Annotation( "GOC:go_curators") "Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.") -AnnotationAssertion( "GO:0051244") AnnotationAssertion( "regulation of cellular physiological process") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0050794") @@ -66719,7 +65365,6 @@ SubClassOf( "GOC:ai") "Any process involved in the maintenance of an internal steady state of monoatomic ions within an organism or cell. Monatomic ions (also called simple ions) are ions consisting of exactly one atom.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/24455"^^xsd:anyURI) -AnnotationAssertion( "GO:2000021") AnnotationAssertion( "ion homeostasis") AnnotationAssertion( "biological_process") AnnotationAssertion( "electrolyte homeostasis") @@ -66887,9 +65532,6 @@ SubClassOf( (defense response to fungus) AnnotationAssertion(Annotation( "GOC:ai") "Reactions triggered in response to the presence of a fungus that act to protect the cell or organism.") -AnnotationAssertion( "GO:0009623") -AnnotationAssertion( "GO:0009817") -AnnotationAssertion( "GO:0042831") AnnotationAssertion( "defence response to fungi") AnnotationAssertion( "defence response to fungus") AnnotationAssertion( "defense response to fungi") @@ -67249,7 +65891,6 @@ SubClassOf( ObjectSomeValuesFrom( (response to stimulus) AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:bf") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.") -AnnotationAssertion( "GO:0051869") AnnotationAssertion( "physiological response to stimulus") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0050896") @@ -67354,8 +65995,6 @@ SubClassOf( (detection of mechanical stimulus involved in sensory perception of sound) AnnotationAssertion(Annotation( "GOC:ai") "The series of events involved in the perception of sound vibration in which the vibration is received and converted into a molecular signal.") -AnnotationAssertion( "GO:0009592") -AnnotationAssertion( "GO:0055128") AnnotationAssertion( "detection of sound") AnnotationAssertion( "hearing, sensory transduction of sound") AnnotationAssertion( "perception of sound, detection of mechanical stimulus") @@ -67445,8 +66084,6 @@ SubClassOf( ObjectSomeValuesFrom( (pigment cell differentiation) AnnotationAssertion(Annotation( "GOC:dgh") "The process in which a relatively unspecialized cell acquires the specialized features of a pigmented cell, such as a melanocyte.") -AnnotationAssertion( "GO:0043357") -AnnotationAssertion( "GO:0043358") AnnotationAssertion( "chromatophore differentiation") AnnotationAssertion( "pigmented cell differentiation") AnnotationAssertion( "biological_process") @@ -67928,7 +66565,6 @@ EquivalentClasses( ObjectIntersection # Class: (actin filament bundle assembly) AnnotationAssertion(Annotation( "GOC:ai") "The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.") -AnnotationAssertion( "GO:0045011") AnnotationAssertion( "biological_process") AnnotationAssertion( "actin bundling activity") AnnotationAssertion(Annotation( "GOC:mah") "actin cable assembly") @@ -68161,44 +66797,6 @@ EquivalentClasses( ObjectIntersection SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) -# Class: (regulation of DNA-binding transcription factor activity) - -AnnotationAssertion(Annotation( "GOC:ai") "Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.") -AnnotationAssertion( "GO:1904167") -AnnotationAssertion( "GO:2000823") -AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "regulation of transcription factor activity") -AnnotationAssertion( "regulation of DNA binding transcription factor activity") -AnnotationAssertion( "regulation of sequence-specific DNA binding transcription factor activity") -AnnotationAssertion( "regulation of androgen receptor activity") -AnnotationAssertion( "regulation of thyroid hormone receptor activity") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "GO:0051090") -AnnotationAssertion( ) -AnnotationAssertion(rdfs:label "regulation of DNA-binding transcription factor activity") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) - -# Class: (positive regulation of DNA-binding transcription factor activity) - -AnnotationAssertion(Annotation( "GOC:ai") "Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.") -AnnotationAssertion( "rph") -AnnotationAssertion( "2015-04-22T12:22:16Z") -AnnotationAssertion( "GO:1904169") -AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "positive regulation of transcription factor activity") -AnnotationAssertion( "positive regulation of DNA binding transcription factor activity") -AnnotationAssertion( "positive regulation of sequence-specific DNA binding transcription factor activity") -AnnotationAssertion( "up regulation of transcription factor activity") -AnnotationAssertion( "up-regulation of transcription factor activity") -AnnotationAssertion( "upregulation of transcription factor activity") -AnnotationAssertion( "activation of transcription factor activity") -AnnotationAssertion( "positive regulation of thyroid hormone receptor activity") -AnnotationAssertion( "stimulation of transcription factor activity") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "GO:0051091") -AnnotationAssertion( ) -AnnotationAssertion(rdfs:label "positive regulation of DNA-binding transcription factor activity") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) - # Class: (negative regulation of developmental process) AnnotationAssertion(Annotation( "GOC:ai") "Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).") @@ -68653,7 +67251,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:ai") "The directed movement of substances into the nucleus.") AnnotationAssertion( "jl") AnnotationAssertion( "2013-12-19T15:26:34Z") -AnnotationAssertion( "GO:1902593") AnnotationAssertion( "nuclear import") AnnotationAssertion( "nuclear translocation") AnnotationAssertion( "biological_process") @@ -68667,7 +67264,6 @@ AnnotationAssertion(Annotation( "https://github.com/geneontology/go-ontology/issues/27052"^^xsd:anyURI) AnnotationAssertion( "jl") AnnotationAssertion( "2013-12-18T13:51:04Z") -AnnotationAssertion( "GO:1902578") AnnotationAssertion( "establishment and maintenance of localization") AnnotationAssertion( "establishment and maintenance of position") AnnotationAssertion(Annotation( "GOC:mah") "localisation") @@ -68864,7 +67460,6 @@ SubClassOf( ObjectSomeValuesFrom( "GOC:ai") "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/23112"^^xsd:anyURI) -AnnotationAssertion( "GO:0032268") AnnotationAssertion( "regulation of protein metabolism") AnnotationAssertion( "biological_process") AnnotationAssertion( "regulation of cellular protein metabolic process") @@ -68877,7 +67472,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:ai") "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/23112"^^xsd:anyURI) -AnnotationAssertion( "GO:0032270") AnnotationAssertion( "positive regulation of cellular protein metabolic process") AnnotationAssertion( "positive regulation of cellular protein metabolism") AnnotationAssertion( "positive regulation of protein metabolism") @@ -68900,7 +67494,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:ai") "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/23112"^^xsd:anyURI) -AnnotationAssertion( "GO:0032269") AnnotationAssertion( "down regulation of cellular protein metabolic process") AnnotationAssertion( "down regulation of protein metabolic process") AnnotationAssertion( "down-regulation of cellular protein metabolic process") @@ -69021,9 +67614,6 @@ SubClassOf( "GOC:ai") Annotation( "GOC:dph") Annotation( "GOC:jl") Annotation( "GOC:mah") "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/22811"^^xsd:anyURI) AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/4585"^^xsd:anyURI) -AnnotationAssertion( "GO:0006323") -AnnotationAssertion( "GO:0007001") -AnnotationAssertion( "GO:0051277") AnnotationAssertion( "DNA condensation") AnnotationAssertion( "chromosome organisation") AnnotationAssertion( "DNA packaging") @@ -69199,7 +67789,6 @@ SubClassOf( "GOC:ai") "Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/24599"^^xsd:anyURI) -AnnotationAssertion( "GO:0007126") AnnotationAssertion( "Wikipedia:Meiosis") AnnotationAssertion( "biological_process") AnnotationAssertion( "meiosis") @@ -69406,6 +67995,18 @@ EquivalentClasses( ObjectIntersection SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) +# Class: (microtubule nucleation by microtubule organizing center) + +AnnotationAssertion(Annotation( "GOC:ai") "The 'de novo' formation of a microtubule, mediated by the microtubule organizing center.") +AnnotationAssertion( "MTOC-mediated microtubule nucleation") +AnnotationAssertion( "microtubule nucleation by MTOC") +AnnotationAssertion( "microtubule nucleation by microtubule organising centre") +AnnotationAssertion( "microtubule organizing center-mediated microtubule nucleation") +AnnotationAssertion( "biological_process") +AnnotationAssertion( "GO:0051418") +AnnotationAssertion(rdfs:label "microtubule nucleation by microtubule organizing center") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (regulation of meiotic cell cycle) AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the rate or extent of progression through the meiotic cell cycle.") @@ -69572,7 +68173,6 @@ SubClassOf( ObjectSomeValuesFrom( (vesicle fusion with vacuole) AnnotationAssertion(Annotation( "GOC:ai") "The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the vacuole.") -AnnotationAssertion( "GO:0042146") AnnotationAssertion( "biological_process") AnnotationAssertion( "heterotypic vacuole fusion (non-autophagic)") AnnotationAssertion( "heterotypic vacuole fusion, non-autophagic") @@ -69974,7 +68574,6 @@ AnnotationAssertion(Annotation( "https://github.com/geneontology/go-ontology/issues/27189"^^xsd:anyURI) AnnotationAssertion( "jl") AnnotationAssertion( "2013-12-18T14:04:32Z") -AnnotationAssertion( "GO:1902580") AnnotationAssertion(Annotation( "GOC:mah") "cellular localisation") AnnotationAssertion( "establishment and maintenance of cellular localization") AnnotationAssertion( "establishment and maintenance of localization in cell or cell membrane") @@ -70183,8 +68782,6 @@ SubClassOf( (response to other organism) AnnotationAssertion(Annotation( "GOC:ai") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism.") -AnnotationAssertion( "GO:0009613") -AnnotationAssertion( "GO:0042828") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0051707") AnnotationAssertion(rdfs:label "response to other organism") @@ -70205,12 +68802,6 @@ SubClassOf( (regulation of cell cycle) AnnotationAssertion(Annotation( "GOC:ai") Annotation( "GOC:dph") Annotation( "GOC:tb") "Any process that modulates the rate or extent of progression through the cell cycle.") -AnnotationAssertion( "GO:0000074") -AnnotationAssertion( "GO:0007050") -AnnotationAssertion( "GO:0071156") -AnnotationAssertion( "GO:0071157") -AnnotationAssertion( "GO:0071158") -AnnotationAssertion( "GO:0071850") AnnotationAssertion( "cell cycle modulation") AnnotationAssertion( "cell cycle regulation") AnnotationAssertion( "control of cell cycle progression") @@ -70296,6 +68887,22 @@ EquivalentClasses( ObjectIntersection SubClassOf( ) SubClassOf( ) +# Class: (short-chain fatty acid biosynthetic process) + +AnnotationAssertion(Annotation( "Wikipedia:Fatty_acid_metabolism") "The chemical reactions and pathways resulting in the formation of a short-chain fatty acid. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons.") +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/26445"^^xsd:anyURI) +AnnotationAssertion( "short chain fatty acid biosynthesis") +AnnotationAssertion( "short chain fatty acid biosynthetic process") +AnnotationAssertion( "short-chain fatty acid anabolism") +AnnotationAssertion( "short-chain fatty acid biosynthesis") +AnnotationAssertion( "short-chain fatty acid formation") +AnnotationAssertion( "short-chain fatty acid synthesis") +AnnotationAssertion( "biological_process") +AnnotationAssertion( "GO:0051790") +AnnotationAssertion(rdfs:comment "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).") +AnnotationAssertion(rdfs:label "short-chain fatty acid biosynthetic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (regulation of hair follicle development) AnnotationAssertion(Annotation( "GOC:ai") "Any process that modulates the frequency, rate or extent of hair follicle development.") @@ -70783,7 +69390,6 @@ SubClassOf( (muscle cell development) AnnotationAssertion(Annotation( "CL:0000187") Annotation( "GOC:devbiol") "The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate.") -AnnotationAssertion( "GO:0048747") AnnotationAssertion( "muscle fiber development") AnnotationAssertion( "muscle fibre development") AnnotationAssertion( "myofiber development") @@ -70897,7 +69503,6 @@ SubClassOf( (cardiac muscle cell development) AnnotationAssertion(Annotation( "GOC:devbiol") Annotation( "GOC:mtg_heart") "The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state.") -AnnotationAssertion( "GO:0048739") AnnotationAssertion( "cardiac muscle fiber development") AnnotationAssertion( "cardiac muscle fibre development") AnnotationAssertion(Annotation( "GOC:mtg_muscle") "cardiomyocyte cell development") @@ -71055,7 +69660,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:jid") Annotation( "GOC:jsg") Annotation( "GOC:mah") "Enables the transfer of the D-enantiomer of the hexose monosaccharide glucose from one side of a membrane to the other.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/27326"^^xsd:anyURI) -AnnotationAssertion( "GO:0015579") AnnotationAssertion(Annotation(rdfs:label "SLC2A6,8,10,12 transport Glc from extracellular region to cytosol") "Reactome:R-HSA-429094") AnnotationAssertion(Annotation(rdfs:label "GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region") "Reactome:R-HSA-450095") AnnotationAssertion(Annotation(rdfs:label "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2") "Reactome:R-HSA-499981") @@ -71152,7 +69756,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:jid") "The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.") AnnotationAssertion( "tb") AnnotationAssertion( "2015-10-21T13:22:47Z") -AnnotationAssertion( "GO:0090662") AnnotationAssertion( "membrane transport") AnnotationAssertion( "ATP hydrolysis coupled transmembrane transport") AnnotationAssertion( "biological_process") @@ -71427,7 +70030,6 @@ SubClassOf( ObjectSomeValuesFrom( (retina development in camera-type eye) AnnotationAssertion(Annotation( "GOC:bf") Annotation( "GOC:dph") Annotation( "ISBN:0815340729") "The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.") -AnnotationAssertion( "GO:0002073") AnnotationAssertion( "retina development in camera-style eye") AnnotationAssertion( "biological_process") AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "retinal development") @@ -71658,7 +70260,6 @@ SubClassOf( (molecular adaptor activity) AnnotationAssertion(Annotation( "GOC:mtg_MIT_16mar07") Annotation( "GOC:vw") "The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.") -AnnotationAssertion( "GO:0032947") AnnotationAssertion( "protein complex scaffold activity") AnnotationAssertion( "protein-containing complex scaffold activity") AnnotationAssertion( "binding, bridging") @@ -72009,7 +70610,6 @@ SubClassOf( ObjectSomeValuesFrom( (ciliary membrane) AnnotationAssertion(Annotation( "GOC:cilia") Annotation( "GOC:dph") Annotation( "GOC:rph") "The portion of the plasma membrane surrounding a cilium.") -AnnotationAssertion( "GO:0020017") AnnotationAssertion( "cilial membrane") AnnotationAssertion( "cilium membrane") AnnotationAssertion( "flagellar membrane") @@ -72244,7 +70844,6 @@ AnnotationAssertion( ) AnnotationAssertion( ) AnnotationAssertion( ) -AnnotationAssertion( "GO:0042384") AnnotationAssertion( "ciliogenesis") AnnotationAssertion( "cilium formation") AnnotationAssertion( "microtubule-based flagellum assembly") @@ -72320,7 +70919,6 @@ SubClassOf( (cilium-dependent cell motility) AnnotationAssertion(Annotation( "GOC:cilia") Annotation( "GOC:dgh") Annotation( "GOC:dph") Annotation( "GOC:krc") Annotation( "GOC:mlg") Annotation( "GOC:mtg_cambridge_2013") "Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.") -AnnotationAssertion( "GO:0071974") AnnotationAssertion( "cilium cell motility") AnnotationAssertion( "microtubule-based flagellar cell motility") AnnotationAssertion( "biological_process") @@ -72587,7 +71185,6 @@ SubClassOf( (response to ammonium ion) AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000071") Annotation( "PMID:23509267") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium stimulus.") -AnnotationAssertion( "GO:1903717") AnnotationAssertion( "response to ammonia") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0060359") @@ -72698,7 +71295,6 @@ SubClassOf( (cardiac septum morphogenesis) AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_heart") "The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart.") -AnnotationAssertion( "GO:0003280") AnnotationAssertion( "heart septum morphogenesis") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0060411") @@ -72723,7 +71319,6 @@ SubClassOf( ObjectSomeValuesFrom( (atrial septum morphogenesis) AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:mtg_heart") "The developmental process in which atrial septum is generated and organized. The atrial septum separates the upper chambers (the atria) of the heart from one another.") -AnnotationAssertion( "GO:0003287") AnnotationAssertion(Annotation( "GOC:dph") "interatrial septum morphogenesis") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0060413") @@ -75546,8 +74141,6 @@ SubClassOf( ObjectSomeValuesFrom( "GOC:dph") Annotation( "GOC:tb") "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.") AnnotationAssertion( "jl") AnnotationAssertion( "2010-02-08T02:43:11Z") -AnnotationAssertion( "GO:0016044") -AnnotationAssertion( "GO:0044802") AnnotationAssertion( "cellular membrane organisation") AnnotationAssertion( "cellular membrane organization") AnnotationAssertion(Annotation( "GOC:mah") "membrane organisation") @@ -75570,8 +74163,6 @@ SubClassOf( "GOC:dph") Annotation( "GOC:tb") "The membrane organization process that joins two lipid bilayers to form a single membrane.") AnnotationAssertion( "jl") AnnotationAssertion( "2010-02-08T02:48:06Z") -AnnotationAssertion( "GO:0006944") -AnnotationAssertion( "GO:0044801") AnnotationAssertion( "Wikipedia:Lipid_bilayer_fusion") AnnotationAssertion( "cellular membrane fusion") AnnotationAssertion( "biological_process") @@ -77331,7 +75922,6 @@ SubClassOf( ObjectAllValuesFrom( "CL:0000474") Annotation( "GOC:dph") Annotation( "GOC:mtg_kidney_jan10") Annotation( "GOC:sart") Annotation( "PMID:19783135") "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a pericardial nephrocyte. A pericardial nephrocyte is an insect renal cell that filters hemolymph and is found with other pericardial nephrocytes in two rows flanking the dorsal vessel. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.") AnnotationAssertion( "dph") AnnotationAssertion( "2010-09-24T12:25:53Z") -AnnotationAssertion( "GO:0007513") AnnotationAssertion( "pericardial cell differentiation") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0061320") @@ -77344,7 +75934,6 @@ SubClassOf( "CL:0000486") Annotation( "GOC:dph") Annotation( "GOC:mtg_kidney_jan10") Annotation( "GOC:sart") Annotation( "PMID:19783135") "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a garland nephrocyte. A garland nephrocyte is an insect renal cell that filters hemolymph and forms a ring with other garland nephrocytes around the esophagus. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.") AnnotationAssertion( "dph") AnnotationAssertion( "2010-09-24T12:28:16Z") -AnnotationAssertion( "GO:0007514") AnnotationAssertion( "garland cell differentiation") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0061321") @@ -78313,9 +76902,6 @@ AnnotationAssertion(Annotation( "https://github.com/geneontology/go-ontology/issues/19354"^^xsd:anyURI) AnnotationAssertion( "dph") AnnotationAssertion( "2014-05-15T09:12:24Z") -AnnotationAssertion( "GO:0001085") -AnnotationAssertion( "GO:0001102") -AnnotationAssertion( "GO:0001103") AnnotationAssertion( "RNA polymerase II sequence-specific DNA binding transcription factor binding") AnnotationAssertion( "RNA polymerase II sequence-specific DNA-binding transcription factor binding") AnnotationAssertion( "molecular_function") @@ -78369,13 +76955,13 @@ SubClassOf( (cytosolic lipolysis) AnnotationAssertion(Annotation( "GOC:autophagy") "The chemical reactions and pathways resulting in the breakdown of lipid droplets and hydrolysis of stored triglycerides occurring through the orchestrated activation of cytosolic lipases.") +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/28908"^^xsd:anyURI) AnnotationAssertion( "dph") AnnotationAssertion( "2015-07-08T13:42:15Z") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0061725") AnnotationAssertion(rdfs:label "cytosolic lipolysis") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) -SubClassOf( ) # Class: (secretory granule maturation) @@ -78388,6 +76974,18 @@ AnnotationAssertion(rdfs:label "secr EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) +# Class: (microtubule organizing center localization) + +AnnotationAssertion(Annotation( "PMID:21281821") "Any process in which the microtubule organizing center is transported to, and/or maintained in, a specific location within the cell.") +AnnotationAssertion( "MTOC localization") +AnnotationAssertion( "MTOC polarity") +AnnotationAssertion( "microtubule organizing center polarity") +AnnotationAssertion( "biological_process") +AnnotationAssertion( "GO:0061842") +AnnotationAssertion(rdfs:label "microtubule organizing center localization") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + # Class: (antimicrobial humoral immune response mediated by antimicrobial peptide) AnnotationAssertion(Annotation( "PMID:15761415") Annotation( "PMID:24287494") "An immune response against microbes mediated by anti-microbial peptides in body fluid.") @@ -78786,9 +77384,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:jl") "The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/22580"^^xsd:anyURI) -AnnotationAssertion( "GO:0006461") -AnnotationAssertion( "GO:0034622") -AnnotationAssertion( "GO:0043623") AnnotationAssertion( "cellular protein complex assembly") AnnotationAssertion( "biological_process") AnnotationAssertion( "cellular macromolecule complex assembly") @@ -79773,7 +78368,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of protein processing, a protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein.") AnnotationAssertion( "mah") AnnotationAssertion( "2009-04-29T02:49:14Z") -AnnotationAssertion( "GO:0010953") AnnotationAssertion( "regulation of protein maturation by peptide bond cleavage") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0070613") @@ -79972,7 +78566,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:bf") Annotation( "GOC:mah") "Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity.") AnnotationAssertion( "mah") AnnotationAssertion( "2009-07-31T01:22:47Z") -AnnotationAssertion( "GO:0045502") AnnotationAssertion( "molecular_function") AnnotationAssertion( "dynein binding") AnnotationAssertion( "GO:0070840") @@ -80002,8 +78595,8 @@ AnnotationAssertion( "GO:0070857") AnnotationAssertion(rdfs:label "regulation of bile acid biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) SubClassOf( ) -SubClassOf( ) SubClassOf( ) SubClassOf( ) @@ -80024,8 +78617,8 @@ AnnotationAssertion( "GO:0070858") AnnotationAssertion(rdfs:label "negative regulation of bile acid biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) SubClassOf( ) -SubClassOf( ) SubClassOf( ) SubClassOf( ) @@ -80047,8 +78640,8 @@ AnnotationAssertion( "GO:0070859") AnnotationAssertion(rdfs:label "positive regulation of bile acid biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) SubClassOf( ) -SubClassOf( ) SubClassOf( ) SubClassOf( ) @@ -80260,7 +78853,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000071") Annotation( "PMID:23509267") "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium stimulus.") AnnotationAssertion( "mah") AnnotationAssertion( "2009-12-03T02:39:40Z") -AnnotationAssertion( "GO:1903718") AnnotationAssertion( "cellular response to ammonia") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0071242") @@ -81063,7 +79655,6 @@ SubClassOf( ObjectSomeValuesFrom( "GOC:mah") "A process in which a potassium ion is transported from one side of a membrane to the other.") AnnotationAssertion( "mah") AnnotationAssertion( "2010-09-03T02:43:49Z") -AnnotationAssertion( "GO:0010163") AnnotationAssertion( "potassium ion membrane transport") AnnotationAssertion( "high affinity potassium ion import") AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "high affinity potassium ion uptake") @@ -81147,7 +79738,6 @@ AnnotationAssertion(Annotation( "https://github.com/geneontology/go-ontology/issues/27189"^^xsd:anyURI) AnnotationAssertion( "mah") AnnotationAssertion( "2010-09-10T01:39:16Z") -AnnotationAssertion( "GO:0071841") AnnotationAssertion(Annotation( "GOC:mah") "cellular component organisation or biogenesis") AnnotationAssertion(Annotation( "GOC:mah") "cellular component organisation or biogenesis at cellular level") AnnotationAssertion( "cellular component organization or biogenesis at cellular level") @@ -81558,7 +80148,6 @@ SubClassOf( ObjectSomeValuesFrom( "GOC:mtg_kidney_jan10") "The process whose specific outcome is the progression of the thick ascending limb over time, from its formation to the mature structure. The thick ascending limb is the last part of the loop of Henle. Its thick, mitochondria-rich epithelium characterizes the outer medulla, and is responsible for very avid active salt transport. At the macula densa, the thick ascending limb connects to the distal convoluted tubule.") AnnotationAssertion( "mah") AnnotationAssertion( "2010-01-25T02:39:51Z") -AnnotationAssertion( "GO:0072026") AnnotationAssertion(Annotation( "GOC:mtg_kidney_jan10") "TAL development") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0072023") @@ -81998,7 +80587,6 @@ SubClassOf( ObjectSomeValuesFrom( "GOC:mtg_kidney_jan10") "The process whose specific outcome is the progression of the loop of Henle over time, from its formation to the mature structure. The loop of Henle is a nephron tubule that connects the proximal convoluted tubule to the distal convoluted tubule.") AnnotationAssertion( "mah") AnnotationAssertion( "2010-01-25T04:20:27Z") -AnnotationAssertion( "GO:0072018") AnnotationAssertion( "intermediate tubule development") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0072070") @@ -83888,7 +82476,6 @@ SubClassOf( ObjectSomeValuesFrom( "GOC:mah") Annotation( "UBERON:0001009") "The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis.") AnnotationAssertion( "mah") AnnotationAssertion( "2010-11-16T11:27:39Z") -AnnotationAssertion( "GO:0072358") AnnotationAssertion( "cardiovascular system development") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0072359") @@ -83927,7 +82514,6 @@ AnnotationAssertion(Annotation( "https://github.com/geneontology/go-ontology/issues/22228"^^xsd:anyURI) AnnotationAssertion( "mah") AnnotationAssertion( "2010-12-10T10:29:57Z") -AnnotationAssertion( "GO:0015696") AnnotationAssertion( "ammonia transport") AnnotationAssertion( "ammonium transport") AnnotationAssertion( "ammonium membrane transport") @@ -84079,7 +82665,6 @@ AnnotationAssertion( "GO:0072592") AnnotationAssertion(rdfs:label "oxygen metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) # Class: (establishment of protein localization to organelle) @@ -84126,8 +82711,6 @@ SubClassOf( "GOC:mah") "A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.") AnnotationAssertion( "tb") AnnotationAssertion( "2009-07-10T10:29:23Z") -AnnotationAssertion( "GO:0072661") -AnnotationAssertion( "GO:0090002") AnnotationAssertion( "biological_process") AnnotationAssertion(Annotation( "GOC:mah") "protein localisation in plasma membrane") AnnotationAssertion( "protein localization in plasma membrane") @@ -84740,9 +83323,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:krc") Annotation( "PMID:8195186") "The directed movement of an amino acid from outside of a cell, across the plasma membrane and into the cytosol.") AnnotationAssertion( "jl") AnnotationAssertion( "2012-11-14T14:21:41Z") -AnnotationAssertion( "GO:0043092") -AnnotationAssertion( "GO:0044745") -AnnotationAssertion( "GO:1902837") AnnotationAssertion( "L-amino acid import") AnnotationAssertion( "amino acid transmembrane import") AnnotationAssertion( "amino acid import into cell") @@ -85686,7 +84266,6 @@ SubClassOf( "GOC:al") "The directed movement of L-histidine into the vacuole across the vacuolar membrane.") AnnotationAssertion( "tb") AnnotationAssertion( "2012-12-14T11:25:52Z") -AnnotationAssertion( "GO:0090457") AnnotationAssertion( "histidine transmembrane import into vacuole") AnnotationAssertion(Annotation( "GOC:tb") "vacuolar histidine import") AnnotationAssertion( "biological_process") @@ -86078,7 +84657,6 @@ SubClassOf( "GOC:mtg_apoptosis") "The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered.") AnnotationAssertion( "pr") AnnotationAssertion( "2011-11-23T09:30:23Z") -AnnotationAssertion( "GO:0008624") AnnotationAssertion(Annotation( "GOC:mah") "apoptotic signalling pathway") AnnotationAssertion( "induction of apoptosis by extracellular signals") AnnotationAssertion( "biological_process") @@ -86347,7 +84925,6 @@ SubClassOf( "GOC:pr") "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure.") AnnotationAssertion( "pr") AnnotationAssertion( "2012-11-27T15:46:25Z") -AnnotationAssertion( "GO:0043206") AnnotationAssertion( "extracellular fibril organisation") AnnotationAssertion( "extracellular fibril organization") AnnotationAssertion(Annotation( "GOC:mah") "extracellular fibril organization and biogenesis") @@ -86604,7 +85181,6 @@ AnnotationAssertion(Annotation( "https://github.com/geneontology/go-ontology/issues/23015"^^xsd:anyURI) AnnotationAssertion( "pr") AnnotationAssertion( "2014-01-23T11:05:13Z") -AnnotationAssertion( "GO:0060401") AnnotationAssertion( "calcium transmembrane import into cytosol") AnnotationAssertion( "cytosolic calcium ion transport") AnnotationAssertion( "biological_process") @@ -86629,8 +85205,6 @@ AnnotationAssertion(Annotation( "https://github.com/geneontology/go-ontology/issues/14265"^^xsd:anyURI) AnnotationAssertion( "pr") AnnotationAssertion( "2009-12-16T11:10:45Z") -AnnotationAssertion( "GO:0071435") -AnnotationAssertion( "GO:0098668") AnnotationAssertion(Annotation( "GOC:mah") "potassium export") AnnotationAssertion( "potassium ion export") AnnotationAssertion( "potassium export across plasma membrane") @@ -86804,6 +85378,25 @@ AnnotationAssertion( "extracellular exosome biogenesis") SubClassOf( ) +# Class: (de novo centriole assembly) + +AnnotationAssertion(Annotation( "GOC:cilia") Annotation( "PMID:25047614") Annotation( "PMID:25291643") "Centriole assembly in which a centriole arises de novo, rather than by replication from an existing centriole. This process may occur via different mechanisms. Examples include the deuterosome pathway in multicilated epithelial animal cells and formation of centrioles during parthenogenesis in some insects.") +AnnotationAssertion( "pr") +AnnotationAssertion( "2016-10-19T15:13:50Z") +AnnotationAssertion( "biological_process") +AnnotationAssertion( "acentriolar basal body biogenesis") +AnnotationAssertion( "de novo basal body amplification") +AnnotationAssertion( "de novo basal body assembly") +AnnotationAssertion( "de novo basal body biogenesis") +AnnotationAssertion( "de novo basal body generation") +AnnotationAssertion( "de novo centriole amplification") +AnnotationAssertion( "de novo ciliary basal body assembly") +AnnotationAssertion( "multiciliation") +AnnotationAssertion( "multiciliogenesis") +AnnotationAssertion( "GO:0097742") +AnnotationAssertion(rdfs:label "de novo centriole assembly") +SubClassOf( ) + # Class: (excitatory neuromuscular junction) AnnotationAssertion(Annotation( "GOC:dos") "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a post-synaptic potential responsible for muscle contraction.") @@ -86888,18 +85481,49 @@ EquivalentClasses( ObjectIntersection SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) -# Class: (ligand-activated transcription factor activity) - -AnnotationAssertion(Annotation( "GOC:dos") Annotation( "PMID:25568920") Annotation( "PMID:8735275") "A DNA-binding transcription factor activity regulated by binding to a ligand and that modulates the transcription of specific genes and gene sets. Examples include the lac and trp repressors in E.coli and steroid hormone receptors.") -AnnotationAssertion( "dos") -AnnotationAssertion( "2013-10-17T15:51:30Z") -AnnotationAssertion( "direct ligand regulated sequence-specific DNA binding transcription factor activity") -AnnotationAssertion( "transcription factor activity, direct ligand regulated sequence-specific DNA binding") -AnnotationAssertion( "molecular_function") -AnnotationAssertion( "GO:0098531") -AnnotationAssertion(rdfs:comment "For usage guidance, see comment in GO:0003700 ; DNA-binding transcription factor activity.") -AnnotationAssertion(rdfs:label "ligand-activated transcription factor activity") -SubClassOf( ) +# Class: (centriole assembly) + +AnnotationAssertion(Annotation( "GOC:dos") Annotation( "PMID:24075808") "A cellular process that results in the assembly of one or more centrioles.") +AnnotationAssertion( "dos") +AnnotationAssertion( "2013-10-22T15:55:22Z") +AnnotationAssertion( "biological_process") +AnnotationAssertion( "GO:0098534") +AnnotationAssertion(rdfs:label "centriole assembly") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) + +# Class: (de novo centriole assembly involved in multi-ciliated epithelial cell differentiation) + +AnnotationAssertion(Annotation( "GOC:cilia") Annotation( "GOC:dos") Annotation( "PMID:24075808") Annotation( "PMID:5111878") Annotation( "PMID:5661997") "Centriole assembly in which a centriole arises de novo by a process involving an electron-dense structure known as a deuterosome, rather than by duplication of an existing centriole, and occurring as part of multi-ciliated epithelial cell differentiation.") +AnnotationAssertion( "dos") +AnnotationAssertion( "2013-10-22T16:03:13Z") +AnnotationAssertion( "de novo centriole assembly") +AnnotationAssertion( "de novo centriole assembly via deuterosome") +AnnotationAssertion( "biological_process") +AnnotationAssertion(Annotation( "PMID:24075808") "centriole amplification") +AnnotationAssertion( "deuterosomal basal body biogenesis") +AnnotationAssertion(Annotation( "PMID:25047614") "deuterosome pathway") +AnnotationAssertion(Annotation( "PMID:24075808") "deuterosome-mediated centriole biogenesis") +AnnotationAssertion( "multiciliation") +AnnotationAssertion( "multiciliogenesis") +AnnotationAssertion( "GO:0098535") +AnnotationAssertion(rdfs:comment "In most eukaryotic cells, 'centriole' (GO:0005814) and 'ciliary basal body' (GO:0036064) represent a common entity that cycles through its function in cell division, then ciliogenesis, then cell division again. However, these structures are modified extensively as they transition into each other, and may contain different proteins, specific to each component.") +AnnotationAssertion(rdfs:label "de novo centriole assembly involved in multi-ciliated epithelial cell differentiation") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) + +# Class: (deuterosome) + +AnnotationAssertion(Annotation( "GOC:cilia") Annotation( "GOC:dos") Annotation( "PMID:24075808") Annotation( "PMID:25047614") Annotation( "PMID:5661997") "A spherical, electron dense, cytoplasmic structure that is involved in de novo assembly of centrioles.") +AnnotationAssertion( "dos") +AnnotationAssertion( "2013-10-22T16:21:19Z") +AnnotationAssertion( "cellular_component") +AnnotationAssertion( "GO:0098536") +AnnotationAssertion(rdfs:label "deuterosome") +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) +SubClassOf( ObjectAllValuesFrom( )) # Class: (obsolete lobed nucleus) @@ -86919,7 +85543,6 @@ AnnotationAssertion(Annotation( "https://github.com/geneontology/go-ontology/issues/22173"^^xsd:anyURI) AnnotationAssertion( "dos") AnnotationAssertion( "2013-11-11T12:59:11Z") -AnnotationAssertion( "GO:0009814") AnnotationAssertion( "defence response incompatible interaction") AnnotationAssertion( "defence response to pathogen, incompatible interaction") AnnotationAssertion( "defense response, incompatible interaction") @@ -86992,7 +85615,6 @@ SubClassOf( "GOC:dos") "The attachment of one cell to another cell via adhesion molecules.") AnnotationAssertion( "dos") AnnotationAssertion( "2014-04-16T13:40:03Z") -AnnotationAssertion( "GO:0016337") AnnotationAssertion( "biological_process") AnnotationAssertion( "single organismal cell-cell adhesion") AnnotationAssertion( "GO:0098609") @@ -87045,7 +85667,6 @@ EquivalentClasses( ObjectIntersection # Class: (protein complex involved in cell adhesion) AnnotationAssertion(Annotation( "GOC:dos") "Any protein complex that is capable of carrying out some part of the process of cell adhesion to the cell matrix or to another cell.") -AnnotationAssertion( "GO:1990307") AnnotationAssertion( "cellular_component") AnnotationAssertion( "cell adhesion complex") AnnotationAssertion( "GO:0098636") @@ -87115,7 +85736,6 @@ SubClassOf( ObjectSomeValuesFrom( (monoatomic cation transmembrane transport) AnnotationAssertion(Annotation( "GOC:dos") Annotation( "GOC:vw") "The process in which a monoatomic cation is transported across a membrane. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom.") -AnnotationAssertion( "GO:0099132") AnnotationAssertion( "cation transmembrane transport") AnnotationAssertion( "ATP hydrolysis coupled cation transmembrane transport") AnnotationAssertion( "biological_process") @@ -87210,7 +85830,6 @@ AnnotationAssertion(Annotation( "https://github.com/geneontology/go-ontology/issues/24965"^^xsd:anyURI) AnnotationAssertion( "mah") AnnotationAssertion( "2013-02-07T13:07:59Z") -AnnotationAssertion( "GO:1990035") AnnotationAssertion( "calcium ion import into cell") AnnotationAssertion(Annotation( "GOC:vw") "calcium ion uptake into cell") AnnotationAssertion( "biological_process") @@ -87225,7 +85844,6 @@ SubClassOf( "GOC:dos") "The directed movement of a carbohydrate from outside of a cell, across the plasma membrane and into the cytosol.") AnnotationAssertion( "pr") AnnotationAssertion( "2012-05-31T02:45:02Z") -AnnotationAssertion( "GO:0097319") AnnotationAssertion( "carbohydrate import into cell") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0098704") @@ -87237,8 +85855,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:dos") "The directed movement of D-glucose from outside of a cell, across the plasma membrane and into the cytosol.") AnnotationAssertion( "al") AnnotationAssertion( "2012-12-06T14:54:07Z") -AnnotationAssertion( "GO:0061490") -AnnotationAssertion( "GO:1990821") AnnotationAssertion( "glucose import across plasma membrane") AnnotationAssertion( "glucose import into cell") AnnotationAssertion( "high affinity glucose import") @@ -87252,9 +85868,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:mah") Annotation( "PMID:8321236") "The directed movement of iron ions from outside of a cell, across the plasma membrane and into the cytosol.") AnnotationAssertion( "pr") AnnotationAssertion( "2012-12-20T08:29:00Z") -AnnotationAssertion( "GO:0097459") -AnnotationAssertion( "GO:0097460") -AnnotationAssertion( "GO:0098707") AnnotationAssertion( "iron ion import into cell") AnnotationAssertion( "biological_process") AnnotationAssertion(Annotation( "GOC:mah") "ferrous ion import into cell") @@ -87270,8 +85883,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:dos") "The directed movement of L-glutamate from outside of a cell, across the plasma membrane and into the cytosol.") AnnotationAssertion( "mah") AnnotationAssertion( "2013-06-12T12:32:47Z") -AnnotationAssertion( "GO:1903802") -AnnotationAssertion( "GO:1990123") AnnotationAssertion( "L-glutamate(1-) import across plasma membrane") AnnotationAssertion( "L-glutamate import into cell") AnnotationAssertion( "L-glutamate(1-) import into cell") @@ -87285,8 +85896,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:dos") "The directed movement of sodium ions from outside of a cell, across the plasma membrane and into the cytosol.") AnnotationAssertion( "pr") AnnotationAssertion( "2012-08-03T16:55:52Z") -AnnotationAssertion( "GO:0097369") -AnnotationAssertion( "GO:1990118") AnnotationAssertion( "sodium import") AnnotationAssertion( "sodium ion import into cell") AnnotationAssertion( "biological_process") @@ -88391,7 +87000,6 @@ SubClassOf( ObjectSomeValuesFrom( (supramolecular fiber) AnnotationAssertion(Annotation( "GOC:dos") "A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure.") -AnnotationAssertion( "GO:0043205") AnnotationAssertion( "cellular_component") AnnotationAssertion( "fibril") AnnotationAssertion( "GO:0099512") @@ -89426,18 +88034,20 @@ AnnotationAssertion( "negative regulation of myotube cell migration") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -# Class: (cellular anatomical entity) +# Class: (cellular anatomical structure) -AnnotationAssertion(Annotation( "GOC:kmv") "A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex.") +AnnotationAssertion(Annotation( "GOC:kmv") "A part of a cellular organism consisting of a material entity with granularity above the level of a protein complex but below that of an anatomical system. Note that cellular organisms exclude viruses.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/24200"^^xsd:anyURI) AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/26424"^^xsd:anyURI) +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/28978"^^xsd:anyURI) AnnotationAssertion( "kmv") AnnotationAssertion( "2019-08-12T18:01:37Z") +AnnotationAssertion( "cellular anatomical entity") AnnotationAssertion( "cellular_component") AnnotationAssertion( "GO:0110165") AnnotationAssertion( ) AnnotationAssertion( ) -AnnotationAssertion(rdfs:label "cellular anatomical entity") +AnnotationAssertion(rdfs:label "cellular anatomical structure") SubClassOf( ) SubClassOf( ) SubClassOf( ) @@ -90147,26 +88757,6 @@ AnnotationAssertion( "catalytic activity, acting on a glycoprotein") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -# Class: (transcription regulator activity) - -AnnotationAssertion(Annotation( "GOC:pg") Annotation( "GOC:txnOH-2018") Annotation( "Wikipedia:Transcription_factor") "A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons.") -AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/13588"^^xsd:anyURI) -AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/23609"^^xsd:anyURI) -AnnotationAssertion( "pg") -AnnotationAssertion( "2017-10-18T07:05:44Z") -AnnotationAssertion( "molecular_function") -AnnotationAssertion( "GO:0140110") -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion( ) -AnnotationAssertion(rdfs:label "transcription regulator activity") -SubClassOf( ) - # Class: (extracellular vesicle biogenesis) AnnotationAssertion(Annotation( "PMID:28736435") "The assembly and secretion a set of components to form an extracellular vesicule, a membrane-bounded vesicle that is released into the extracellular region. Extracellular vesicles include exosomes, microvesicles and apoptotic bodies, based on the mechanism by which they are released from cells and differentiated based on their size and content.") @@ -90480,9 +89070,6 @@ AnnotationAssertion(Annotation( "https://github.com/geneontology/go-ontology/issues/19354"^^xsd:anyURI) AnnotationAssertion( "pg") AnnotationAssertion( "2018-11-28T12:48:20Z") -AnnotationAssertion( "GO:0001107") -AnnotationAssertion( "GO:0033613") -AnnotationAssertion( "GO:0070491") AnnotationAssertion( "molecular_function") AnnotationAssertion( "activating transcription factor binding") AnnotationAssertion( "repressing transcription factor binding") @@ -90558,7 +89145,6 @@ AnnotationAssertion(Annotation( "https://github.com/geneontology/go-ontology/issues/19216"^^xsd:anyURI) AnnotationAssertion( "pg") AnnotationAssertion( "2020-04-03T13:30:04Z") -AnnotationAssertion( "GO:0035638") AnnotationAssertion(Annotation( "GOC:bf") "ligand maturation") AnnotationAssertion( "biological_process") AnnotationAssertion( "signal maturation") @@ -90682,18 +89268,20 @@ AnnotationAssertion( "negative regulation of oxytocin production") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -# Class: (non-membrane-bounded organelle assembly) +# Class: (membraneless organelle assembly) AnnotationAssertion(Annotation( "PMID:28225081") "The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/21939"^^xsd:anyURI) +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/29106"^^xsd:anyURI) AnnotationAssertion( "pg") AnnotationAssertion( "2021-08-09T15:30:06Z") +AnnotationAssertion( "non-membrane-bounded organelle assembly") AnnotationAssertion( "non-membrane-bounded organelle formation") AnnotationAssertion( "non-membrane-enclosed organelle assembly") AnnotationAssertion( "non-membrane-enclosed organelle formation") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:0140694") -AnnotationAssertion(rdfs:label "non-membrane-bounded organelle assembly") +AnnotationAssertion(rdfs:label "membraneless organelle assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (ammonium excretion) @@ -90773,18 +89361,6 @@ AnnotationAssertion(rdfs:comment "Th AnnotationAssertion(rdfs:label "nucleic acid catabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -# Class: (nuclear receptor-mediated signaling pathway) - -AnnotationAssertion(Annotation( "PMID:25614732") "The series of molecular signals initiated by a signaling molecule binding to an intracellular receptor of the nuclear receptor protein family, and ending with regulation of a downstream cellular process, e.g. transcription.") -AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/27599"^^xsd:anyURI) -AnnotationAssertion( "pg") -AnnotationAssertion( "2024-04-12T13:08:13Z") -AnnotationAssertion( "nuclear receptor signaling pathway") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "GO:0141193") -AnnotationAssertion(rdfs:label "nuclear receptor-mediated signaling pathway") -SubClassOf( ) - # Class: (regulation of protein localization to lysosome) AnnotationAssertion(Annotation( "GOC:aruk") Annotation( "GOC:bc") Annotation( "PMID:24305806") "Any process that modulates the frequency, rate or extent of protein localization to lysosome.") @@ -91199,13 +89775,16 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "PMID:18400985") "Enables the energy-independent facilitated diffusion of bicarbonate through a transmembrane aqueous pore or channel.") AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/26601"^^xsd:anyURI) AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/26780"^^xsd:anyURI) +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/27521"^^xsd:anyURI) AnnotationAssertion( "rynl") AnnotationAssertion( "2023-12-13T00:09:44Z") +AnnotationAssertion(Annotation( "skos:broadMatch") "RHEA:28695") AnnotationAssertion( "hydrogencarbonate channel activity") AnnotationAssertion( "molecular_function") AnnotationAssertion( "GO:0160133") AnnotationAssertion(rdfs:label "bicarbonate channel activity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ObjectSomeValuesFrom( )) # Class: (CD8-positive, alpha-beta T cell homeostasis) @@ -91231,6 +89810,18 @@ AnnotationAssertion( "histamine transmembrane transporter activity") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (glycine-gated cation channel activity) + +AnnotationAssertion(Annotation( "PMID:11823786") "Enables the transmembrane transfer of a cation by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane.") +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/28887"^^xsd:anyURI) +AnnotationAssertion( "rynl") +AnnotationAssertion( "2024-09-10T16:55:41Z") +AnnotationAssertion( "molecular_function") +AnnotationAssertion( "GO:0160212") +AnnotationAssertion(rdfs:label "glycine-gated cation channel activity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +SubClassOf( ) + # Class: (lipid transmembrane transporter activity) AnnotationAssertion(Annotation( "GOC:curators") "Enables the transfer of a lipid from one side of a membrane to the other.") @@ -91852,7 +90443,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:dhl") Annotation( "PMID:22242006") "Any process that modulates the frequency, rate or extent of defense response to fungus.") AnnotationAssertion( "dhl") AnnotationAssertion( "2012-03-06T10:00:16Z") -AnnotationAssertion( "GO:2000072") AnnotationAssertion(Annotation( "GOC:TermGenie") "regulation of defence response to fungi") AnnotationAssertion(Annotation( "GOC:TermGenie") "regulation of defence response to fungus") AnnotationAssertion(Annotation( "GOC:TermGenie") "regulation of defense response to fungi") @@ -91904,55 +90494,6 @@ AnnotationAssertion( "positive regulation of bone mineralization involved in bone maturation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -# Class: (regulation of glucocorticoid mediated signaling pathway) - -AnnotationAssertion(Annotation( "GOC:TermGenie") "Any process that modulates the frequency, rate or extent of glucocorticoid mediated signaling pathway.") -AnnotationAssertion( "hjd") -AnnotationAssertion( "2012-03-08T08:33:16Z") -AnnotationAssertion(Annotation( "GOC:TermGenie") "regulation of glucocorticoid mediated signalling") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "GO:1900169") -AnnotationAssertion(rdfs:label "regulation of glucocorticoid mediated signaling pathway") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) - -# Class: (negative regulation of glucocorticoid mediated signaling pathway) - -AnnotationAssertion(Annotation( "GOC:TermGenie") "Any process that stops, prevents or reduces the frequency, rate or extent of glucocorticoid mediated signaling pathway.") -AnnotationAssertion( "hjd") -AnnotationAssertion( "2012-03-08T08:33:20Z") -AnnotationAssertion(Annotation( "GOC:TermGenie") "down regulation of glucocorticoid mediated signaling pathway") -AnnotationAssertion(Annotation( "GOC:TermGenie") "down regulation of glucocorticoid mediated signalling") -AnnotationAssertion(Annotation( "GOC:TermGenie") "down-regulation of glucocorticoid mediated signaling pathway") -AnnotationAssertion(Annotation( "GOC:TermGenie") "down-regulation of glucocorticoid mediated signalling") -AnnotationAssertion(Annotation( "GOC:TermGenie") "downregulation of glucocorticoid mediated signaling pathway") -AnnotationAssertion(Annotation( "GOC:TermGenie") "downregulation of glucocorticoid mediated signalling") -AnnotationAssertion(Annotation( "GOC:TermGenie") "negative regulation of glucocorticoid mediated signalling") -AnnotationAssertion(Annotation( "GOC:TermGenie") "inhibition of glucocorticoid mediated signaling pathway") -AnnotationAssertion(Annotation( "GOC:TermGenie") "inhibition of glucocorticoid mediated signalling") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "GO:1900170") -AnnotationAssertion(rdfs:label "negative regulation of glucocorticoid mediated signaling pathway") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) - -# Class: (positive regulation of glucocorticoid mediated signaling pathway) - -AnnotationAssertion(Annotation( "GOC:TermGenie") "Any process that activates or increases the frequency, rate or extent of glucocorticoid mediated signaling pathway.") -AnnotationAssertion( "hjd") -AnnotationAssertion( "2012-03-08T08:33:23Z") -AnnotationAssertion(Annotation( "GOC:TermGenie") "positive regulation of glucocorticoid mediated signalling") -AnnotationAssertion(Annotation( "GOC:TermGenie") "up regulation of glucocorticoid mediated signaling pathway") -AnnotationAssertion(Annotation( "GOC:TermGenie") "up regulation of glucocorticoid mediated signalling") -AnnotationAssertion(Annotation( "GOC:TermGenie") "up-regulation of glucocorticoid mediated signaling pathway") -AnnotationAssertion(Annotation( "GOC:TermGenie") "up-regulation of glucocorticoid mediated signalling") -AnnotationAssertion(Annotation( "GOC:TermGenie") "upregulation of glucocorticoid mediated signaling pathway") -AnnotationAssertion(Annotation( "GOC:TermGenie") "upregulation of glucocorticoid mediated signalling") -AnnotationAssertion(Annotation( "GOC:TermGenie") "activation of glucocorticoid mediated signaling pathway") -AnnotationAssertion(Annotation( "GOC:TermGenie") "activation of glucocorticoid mediated signalling") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "GO:1900171") -AnnotationAssertion(rdfs:label "positive regulation of glucocorticoid mediated signaling pathway") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) - # Class: (regulation of protein localization to nucleus) AnnotationAssertion(Annotation( "GOC:TermGenie") "Any process that modulates the frequency, rate or extent of protein localization to nucleus.") @@ -92511,7 +91052,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "PMID:22346749") "Any process that modulates the frequency, rate or extent of defense response to bacterium.") AnnotationAssertion( "dhl") AnnotationAssertion( "2012-04-24T10:12:43Z") -AnnotationAssertion( "GO:1902477") AnnotationAssertion(Annotation( "GOC:TermGenie") "regulation of defence response to bacteria") AnnotationAssertion(Annotation( "GOC:TermGenie") "regulation of defence response to bacterium") AnnotationAssertion(Annotation( "GOC:TermGenie") "regulation of defense response to bacteria") @@ -92532,7 +91072,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "PMID:22346749") "Any process that stops, prevents or reduces the frequency, rate or extent of defense response to bacterium.") AnnotationAssertion( "dhl") AnnotationAssertion( "2012-04-24T10:12:54Z") -AnnotationAssertion( "GO:1902478") AnnotationAssertion(Annotation( "GOC:TermGenie") "down regulation of defence response to bacteria") AnnotationAssertion(Annotation( "GOC:TermGenie") "down regulation of defence response to bacterium") AnnotationAssertion(Annotation( "GOC:TermGenie") "down regulation of defense response to bacteria") @@ -92575,7 +91114,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "PMID:22346749") "Any process that activates or increases the frequency, rate or extent of defense response to bacterium.") AnnotationAssertion( "dhl") AnnotationAssertion( "2012-04-24T10:13:13Z") -AnnotationAssertion( "GO:1902479") AnnotationAssertion(Annotation( "GOC:TermGenie") "activation of defence response to bacteria") AnnotationAssertion(Annotation( "GOC:TermGenie") "activation of defence response to bacterium") AnnotationAssertion(Annotation( "GOC:TermGenie") "activation of defense response to bacteria") @@ -94113,7 +92651,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:mengo_curators") Annotation( "PMID:23356676") "A response that results in a state of tolerance to ketone.") AnnotationAssertion( "pr") AnnotationAssertion( "2012-11-20T10:55:47Z") -AnnotationAssertion( "GO:1990369") AnnotationAssertion( "process resulting in tolerance to ketone") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:1901654") @@ -94185,7 +92722,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:mtg_apoptosis") Annotation( "PMID:12021768") "Any process that activates or increases the frequency, rate or extent of compound eye retinal cell apoptotic process.") AnnotationAssertion( "pr") AnnotationAssertion( "2012-12-12T10:28:45Z") -AnnotationAssertion( "GO:0046675") AnnotationAssertion(Annotation( "GOC:TermGenie") "up regulation of compound eye retinal cell apoptotic process") AnnotationAssertion(Annotation( "GOC:TermGenie") "up-regulation of compound eye retinal cell apoptotic process") AnnotationAssertion(Annotation( "GOC:TermGenie") "upregulation of compound eye retinal cell apoptotic process") @@ -95476,8 +94012,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:bf") Annotation( "GOC:vw") Annotation( "GO_REF:0000058") Annotation( "PMID:18314879") "Any process that modulates the frequency, rate or extent of chromatin organization.") AnnotationAssertion( "bf") AnnotationAssertion( "2013-07-01T13:21:52Z") -AnnotationAssertion( "GO:0001672") -AnnotationAssertion( "GO:1903308") AnnotationAssertion(Annotation( "GOC:TermGenie") "regulation of chromatin organisation") AnnotationAssertion(Annotation( "GOC:TermGenie") "regulation of establishment or maintenance of chromatin architecture") AnnotationAssertion( "biological_process") @@ -96057,7 +94591,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:dph") Annotation( "GOC:signaling") Annotation( "GOC:tb") "Any process that modulates the frequency, rate or extent of intracellular signal transduction.") AnnotationAssertion( "bf") AnnotationAssertion( "2013-12-02T11:32:52Z") -AnnotationAssertion( "GO:0010627") AnnotationAssertion(Annotation( "GOC:TermGenie") "regulation of intracellular signaling cascade") AnnotationAssertion(Annotation( "GOC:TermGenie") "regulation of intracellular signaling chain") AnnotationAssertion( "regulation of intracellular protein kinase cascade") @@ -96075,7 +94608,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:dph") Annotation( "GOC:signaling") Annotation( "GOC:tb") "Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction.") AnnotationAssertion( "bf") AnnotationAssertion( "2013-12-02T11:33:01Z") -AnnotationAssertion( "GO:0010741") AnnotationAssertion(Annotation( "GOC:TermGenie") "down regulation of intracellular signal transduction") AnnotationAssertion(Annotation( "GOC:TermGenie") "down regulation of intracellular signaling chain") AnnotationAssertion(Annotation( "GOC:TermGenie") "down-regulation of intracellular signal transduction") @@ -96121,7 +94653,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:dph") Annotation( "GOC:signaling") Annotation( "GOC:tb") "Any process that activates or increases the frequency, rate or extent of intracellular signal transduction.") AnnotationAssertion( "bf") AnnotationAssertion( "2013-12-02T11:33:10Z") -AnnotationAssertion( "GO:0010740") AnnotationAssertion(Annotation( "GOC:TermGenie") "positive regulation of intracellular signaling chain") AnnotationAssertion(Annotation( "GOC:TermGenie") "up regulation of intracellular signal transduction") AnnotationAssertion(Annotation( "GOC:TermGenie") "up regulation of intracellular signaling chain") @@ -96292,9 +94823,6 @@ SubClassOf( "GOC:TermGenie") Annotation( "GOC:pr") Annotation( "GO_REF:0000069") "The directed movement of a proton across a membrane.") AnnotationAssertion( "pr") AnnotationAssertion( "2013-12-20T11:08:37Z") -AnnotationAssertion( "GO:0006818") -AnnotationAssertion( "GO:0015991") -AnnotationAssertion( "GO:0015992") AnnotationAssertion( "hydrogen transport") AnnotationAssertion( "proton transport") AnnotationAssertion( "hydrogen ion transmembrane transport") @@ -97537,32 +96065,6 @@ AnnotationAssertion(rdfs:comment "hu AnnotationAssertion(rdfs:label "positive regulation of glycoprotein metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -# Class: (regulation of RNA polymerase II regulatory region sequence-specific DNA binding) - -AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:dph") Annotation( "GOC:krc") Annotation( "GO_REF:0000059") Annotation( "PMID:20026326") "Any process that modulates the frequency, rate or extent of RNA polymerase II regulatory region sequence-specific DNA binding.") -AnnotationAssertion( "dph") -AnnotationAssertion( "2014-05-15T17:55:54Z") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "GO:1903025") -AnnotationAssertion( ) -AnnotationAssertion(rdfs:label "regulation of RNA polymerase II regulatory region sequence-specific DNA binding") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) - -# Class: (negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding) - -AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:dph") Annotation( "GOC:krc") Annotation( "GO_REF:0000059") Annotation( "PMID:20026326") "Any process that stops, prevents or reduces the frequency, rate or extent of RNA polymerase II regulatory region sequence-specific DNA binding.") -AnnotationAssertion( "dph") -AnnotationAssertion( "2014-05-15T17:56:00Z") -AnnotationAssertion(Annotation( "GOC:TermGenie") "down regulation of RNA polymerase II regulatory region sequence-specific DNA binding") -AnnotationAssertion(Annotation( "GOC:TermGenie") "down-regulation of RNA polymerase II regulatory region sequence-specific DNA binding") -AnnotationAssertion(Annotation( "GOC:TermGenie") "downregulation of RNA polymerase II regulatory region sequence-specific DNA binding") -AnnotationAssertion(Annotation( "GOC:TermGenie") "inhibition of RNA polymerase II regulatory region sequence-specific DNA binding") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "GO:1903026") -AnnotationAssertion( ) -AnnotationAssertion(rdfs:label "negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) - # Class: (regulation of response to wounding) AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:kmv") Annotation( "GO_REF:0000058") Annotation( "PMID:19164535") "Any process that modulates the frequency, rate or extent of response to wounding.") @@ -98030,8 +96532,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:rl") Annotation( "GO_REF:0000058") Annotation( "PMID:11602640") "Any process that modulates the frequency, rate or extent of protein localization to plasma membrane.") AnnotationAssertion( "tb") AnnotationAssertion( "2009-07-10T10:32:44Z") -AnnotationAssertion( "GO:0090003") -AnnotationAssertion( "GO:1905963") AnnotationAssertion(Annotation( "GOC:TermGenie") "regulation of protein localization in plasma membrane") AnnotationAssertion( "biological_process") AnnotationAssertion(Annotation( "GOC:mah") "regulation of establishment of protein localisation in plasma membrane") @@ -98049,8 +96549,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:rl") Annotation( "GO_REF:0000058") Annotation( "PMID:11602640") "Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane.") AnnotationAssertion( "tb") AnnotationAssertion( "2014-05-29T17:10:16Z") -AnnotationAssertion( "GO:0090005") -AnnotationAssertion( "GO:1905964") AnnotationAssertion(Annotation( "GOC:TermGenie") "down regulation of protein localisation in plasma membrane") AnnotationAssertion(Annotation( "GOC:TermGenie") "down regulation of protein localization in plasma membrane") AnnotationAssertion(Annotation( "GOC:TermGenie") "down regulation of protein localization to plasma membrane") @@ -98088,8 +96586,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:rl") Annotation( "GO_REF:0000058") Annotation( "PMID:11602640") "Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.") AnnotationAssertion( "tb") AnnotationAssertion( "2009-07-10T10:34:17Z") -AnnotationAssertion( "GO:0090004") -AnnotationAssertion( "GO:1905965") AnnotationAssertion(Annotation( "GOC:TermGenie") "positive regulation of protein localisation in plasma membrane") AnnotationAssertion(Annotation( "GOC:TermGenie") "positive regulation of protein localization in plasma membrane") AnnotationAssertion(Annotation( "GOC:TermGenie") "up regulation of protein localisation in plasma membrane") @@ -98394,7 +96890,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:rl") Annotation( "GO_REF:0000058") Annotation( "PMID:17095720") "Any process that modulates the frequency, rate or extent of sodium ion export across the plasma membrane.") AnnotationAssertion( "rl") AnnotationAssertion( "2014-08-08T17:06:46Z") -AnnotationAssertion( "GO:1903273") AnnotationAssertion( "regulation of sodium ion export from cell") AnnotationAssertion( "biological_process") AnnotationAssertion(Annotation( "GOC:TermGenie") "regulation of sodium export") @@ -98408,7 +96903,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:rl") Annotation( "GO_REF:0000058") Annotation( "PMID:17095720") "Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion export across the plasma membrane.") AnnotationAssertion( "rl") AnnotationAssertion( "2014-08-08T17:10:22Z") -AnnotationAssertion( "GO:1903274") AnnotationAssertion(Annotation( "GOC:TermGenie") "down regulation of sodium ion export from cell") AnnotationAssertion(Annotation( "GOC:TermGenie") "down-regulation of sodium ion export from cell") AnnotationAssertion(Annotation( "GOC:TermGenie") "downregulation of sodium ion export from cell") @@ -98434,7 +96928,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:rl") Annotation( "GO_REF:0000058") Annotation( "PMID:17095720") "Any process that activates or increases the frequency, rate or extent of sodium ion export across the plasma membrane.") AnnotationAssertion( "rl") AnnotationAssertion( "2014-08-08T17:10:30Z") -AnnotationAssertion( "GO:1903275") AnnotationAssertion( "positive regulation of sodium ion export from cell") AnnotationAssertion(Annotation( "GOC:TermGenie") "up regulation of sodium ion export from cell") AnnotationAssertion(Annotation( "GOC:TermGenie") "up-regulation of sodium ion export from cell") @@ -99430,7 +97923,6 @@ AnnotationAssertion(Annotation( "GO:1903561") AnnotationAssertion(rdfs:label "extracellular vesicle") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) # Class: (regulation of protein localization to cilium) @@ -100025,7 +98517,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:mtg_cardiac_conduct_nov11") Annotation( "GOC:rl") Annotation( "GO_REF:0000058") Annotation( "PMID:19646991") "Any process that modulates the frequency, rate or extent of potassium ion export across the plasma membrane.") AnnotationAssertion( "rl") AnnotationAssertion( "2013-07-17T16:39:53Z") -AnnotationAssertion( "GO:1902302") AnnotationAssertion(Annotation( "GOC:TermGenie") "regulation of potassium export") AnnotationAssertion(Annotation( "GOC:TermGenie") "regulation of potassium export across plasma membrane") AnnotationAssertion( "regulation of potassium ion export") @@ -100039,7 +98530,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:mtg_cardiac_conduct_nov11") Annotation( "GOC:rl") Annotation( "GO_REF:0000058") Annotation( "PMID:19646991") "Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion export across the plasma membrane.") AnnotationAssertion( "rl") AnnotationAssertion( "2013-07-17T16:40:02Z") -AnnotationAssertion( "GO:1902303") AnnotationAssertion(Annotation( "GOC:TermGenie") "down regulation of potassium export") AnnotationAssertion(Annotation( "GOC:TermGenie") "down regulation of potassium ion export") AnnotationAssertion(Annotation( "GOC:TermGenie") "down-regulation of potassium export") @@ -100064,7 +98554,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:mtg_cardiac_conduct_nov11") Annotation( "GOC:rl") Annotation( "GO_REF:0000058") Annotation( "PMID:19646991") "Any process that activates or increases the frequency, rate or extent of potassium ion export across the plasma membrane.") AnnotationAssertion( "rl") AnnotationAssertion( "2013-07-17T16:40:10Z") -AnnotationAssertion( "GO:1902304") AnnotationAssertion(Annotation( "GOC:TermGenie") "positive regulation of potassium export") AnnotationAssertion( "positive regulation of potassium ion export") AnnotationAssertion(Annotation( "GOC:TermGenie") "up regulation of potassium export") @@ -100189,7 +98678,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000075") Annotation( "PMID:23895341") "The directed movement of glycine from outside of a cell, across the plasma membrane and into the cytosol.") AnnotationAssertion( "bf") AnnotationAssertion( "2012-05-11T01:16:45Z") -AnnotationAssertion( "GO:0036233") AnnotationAssertion( "glycine import") AnnotationAssertion( "glycine import into cell") AnnotationAssertion( "biological_process") @@ -100202,8 +98690,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000075") Annotation( "PMID:23895341") "The directed movement of L-histidine from outside of a cell, across the plasma membrane and into the cytosol.") AnnotationAssertion( "dph") AnnotationAssertion( "2012-10-05T10:20:50Z") -AnnotationAssertion( "GO:0061460") -AnnotationAssertion( "GO:0090466") AnnotationAssertion( "L-histidine import") AnnotationAssertion( "histidine import") AnnotationAssertion( "L-histidine import into cell") @@ -100723,7 +99209,6 @@ SubClassOf( ObjectSomeValuesFrom( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:kom") Annotation( "GOC:rl") Annotation( "GO_REF:0000074") Annotation( "PMID:15514116") "The directed movement of iron ions from inside of a cell, across the plasma membrane and into the extracellular region.") AnnotationAssertion( "rl") AnnotationAssertion( "2014-09-03T13:01:37Z") -AnnotationAssertion( "GO:1903414") AnnotationAssertion( "ferrous iron export") AnnotationAssertion( "ferrous iron export across plasma membrane") AnnotationAssertion( "biological_process") @@ -101788,7 +100273,7 @@ AnnotationAssertion( "regulation of bile acid metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) -SubClassOf( ) +SubClassOf( ) # Class: (negative regulation of bile acid metabolic process) @@ -101808,7 +100293,7 @@ AnnotationAssertion( "GO:1904252") AnnotationAssertion(rdfs:label "negative regulation of bile acid metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) +SubClassOf( ) SubClassOf( ) SubClassOf( ) @@ -101830,7 +100315,7 @@ AnnotationAssertion( "GO:1904253") AnnotationAssertion(rdfs:label "positive regulation of bile acid metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) +SubClassOf( ) SubClassOf( ) SubClassOf( ) @@ -101849,33 +100334,6 @@ AnnotationAssertion(rdfs:label "regu EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) -# Class: (negative regulation of iron ion transmembrane transporter activity) - -AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:kom") Annotation( "GO_REF:0000059") Annotation( "PMID:15514116") "Any process that stops, prevents or reduces the frequency, rate or extent of an iron transmembrane transporter activity.") -AnnotationAssertion( "kom") -AnnotationAssertion( "2015-05-20T14:05:06Z") -AnnotationAssertion(Annotation( "GOC:TermGenie") "down regulation of iron cation channel activity") -AnnotationAssertion(Annotation( "GOC:TermGenie") "down regulation of iron channel activity") -AnnotationAssertion(Annotation( "GOC:TermGenie") "down regulation of iron-specific channel activity") -AnnotationAssertion(Annotation( "GOC:TermGenie") "down-regulation of iron cation channel activity") -AnnotationAssertion(Annotation( "GOC:TermGenie") "down-regulation of iron channel activity") -AnnotationAssertion(Annotation( "GOC:TermGenie") "down-regulation of iron-specific channel activity") -AnnotationAssertion(Annotation( "GOC:TermGenie") "downregulation of iron cation channel activity") -AnnotationAssertion(Annotation( "GOC:TermGenie") "downregulation of iron channel activity") -AnnotationAssertion(Annotation( "GOC:TermGenie") "downregulation of iron-specific channel activity") -AnnotationAssertion(Annotation( "GOC:TermGenie") "negative regulation of iron cation channel activity") -AnnotationAssertion( "negative regulation of iron channel activity") -AnnotationAssertion(Annotation( "GOC:TermGenie") "negative regulation of iron-specific channel activity") -AnnotationAssertion(Annotation( "GOC:TermGenie") "inhibition of iron cation channel activity") -AnnotationAssertion(Annotation( "GOC:TermGenie") "inhibition of iron channel activity") -AnnotationAssertion(Annotation( "GOC:TermGenie") "inhibition of iron-specific channel activity") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "GO:1904255") -AnnotationAssertion( ) -AnnotationAssertion(rdfs:label "negative regulation of iron ion transmembrane transporter activity") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ObjectSomeValuesFrom( )) - # Class: (regulation of Schwann cell chemotaxis) AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:16203995") "Any process that modulates the frequency, rate or extent of Schwann cell chemotaxis.") @@ -102655,7 +101113,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:kom") Annotation( "GO_REF:0000058") Annotation( "PMID:18353247") "Any process that modulates the frequency, rate or extent of iron ions import across plasma membrane.") AnnotationAssertion( "rl") AnnotationAssertion( "2015-03-04T14:37:36Z") -AnnotationAssertion( "GO:1903989") AnnotationAssertion( "biological_process") AnnotationAssertion(Annotation( "GOC:TermGenie") "regulation of ferrous ion import into cell") AnnotationAssertion( "regulation of ferrous iron import across plasma membrane") @@ -102670,7 +101127,6 @@ SubClassOf( ObjectSomeValuesFrom( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:kom") Annotation( "GO_REF:0000058") Annotation( "PMID:18353247") "Any process that stops, prevents or reduces the frequency, rate or extent of iron ions import across plasma membrane.") AnnotationAssertion( "rl") AnnotationAssertion( "2015-07-06T13:49:58Z") -AnnotationAssertion( "GO:1903990") AnnotationAssertion(Annotation( "GOC:TermGenie") "inhibition of ferrous ion import into cell") AnnotationAssertion(Annotation( "GOC:TermGenie") "inhibition of ferrous iron import across plasma membrane") AnnotationAssertion( "biological_process") @@ -102692,7 +101148,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:TermGenie") Annotation( "GOC:kom") Annotation( "GO_REF:0000058") Annotation( "PMID:18353247") "Any process that activates or increases the frequency, rate or extent of iron ions import across plasma membrane.") AnnotationAssertion( "rl") AnnotationAssertion( "2015-07-06T13:50:04Z") -AnnotationAssertion( "GO:1903991") AnnotationAssertion(Annotation( "GOC:TermGenie") "activation of ferrous ion import into cell") AnnotationAssertion(Annotation( "GOC:TermGenie") "activation of ferrous iron import across plasma membrane") AnnotationAssertion( "biological_process") @@ -103273,7 +101728,6 @@ SubClassOf( ObjectSomeValuesFrom( "GOC:TermGenie") Annotation( "GO_REF:0000069") Annotation( "PMID:9090050") "The process in which D-glucose is transported across a membrane.") AnnotationAssertion( "vw") AnnotationAssertion( "2015-09-04T17:20:16Z") -AnnotationAssertion( "GO:0015758") AnnotationAssertion( "glucose transmembrane transport") AnnotationAssertion( "biological_process") AnnotationAssertion( "glucose transport") @@ -103392,8 +101846,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:vw") Annotation( "GO_REF:0000070") "Enables the transfer of a peptide from one side of a membrane to the other.") AnnotationAssertion( "tb") AnnotationAssertion( "2015-09-22T18:50:41Z") -AnnotationAssertion( "GO:0015197") -AnnotationAssertion( "GO:0015637") AnnotationAssertion(Annotation(rdfs:label "Glutathione is taken up by the bacterium") "Reactome:R-HSA-1500817") AnnotationAssertion( "molecular_function") AnnotationAssertion( "peptide transporter activity") @@ -105096,13 +103548,23 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000078") Annotation( "PMID:26554016") "The directed movement of phosphate ions from the cytosol across the vacuolar membrane and into the vacuolar lumen.") AnnotationAssertion( "tb") AnnotationAssertion( "2016-03-03T00:34:12Z") -AnnotationAssertion( "GO:0007037") AnnotationAssertion( "vacuolar phosphate transport") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:1905011") AnnotationAssertion(rdfs:label "transmembrane phosphate ion transport from cytosol to vacuole") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ) ObjectSomeValuesFrom( ))) +# Class: (regulation of membrane lipid metabolic process) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000058") Annotation( "PMID:25954280") "Any process that modulates the frequency, rate or extent of membrane lipid metabolic process.") +AnnotationAssertion( "tb") +AnnotationAssertion( "2016-03-08T20:41:32Z") +AnnotationAssertion(Annotation( "GOC:TermGenie") "regulation of membrane lipid metabolism") +AnnotationAssertion( "biological_process") +AnnotationAssertion( "GO:1905038") +AnnotationAssertion(rdfs:label "regulation of membrane lipid metabolic process") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (carboxylic acid transmembrane transport) AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000069") Annotation( "PMID:10869563") "The process in which carboxylic acid is transported across a membrane.") @@ -105956,8 +104418,6 @@ AnnotationAssertion(Annotation( "https://github.com/geneontology/go-ontology/issues/22766"^^xsd:anyURI) AnnotationAssertion( "pr") AnnotationAssertion( "2016-06-15T20:14:47Z") -AnnotationAssertion( "GO:0045798") -AnnotationAssertion( "GO:1903309") AnnotationAssertion(Annotation( "GOC:TermGenie") "down regulation of chromatin organisation") AnnotationAssertion(Annotation( "GOC:TermGenie") "down regulation of chromatin organization") AnnotationAssertion(Annotation( "GOC:TermGenie") "down regulation of establishment or maintenance of chromatin architecture") @@ -105990,8 +104450,6 @@ AnnotationAssertion(Annotation( "https://github.com/geneontology/go-ontology/issues/22766"^^xsd:anyURI) AnnotationAssertion( "pr") AnnotationAssertion( "2016-06-15T20:14:56Z") -AnnotationAssertion( "GO:0045799") -AnnotationAssertion( "GO:1903310") AnnotationAssertion(Annotation( "GOC:TermGenie") "positive regulation of chromatin organisation") AnnotationAssertion(Annotation( "GOC:TermGenie") "positive regulation of establishment or maintenance of chromatin architecture") AnnotationAssertion(Annotation( "GOC:TermGenie") "up regulation of chromatin organisation") @@ -107262,6 +105720,19 @@ AnnotationAssertion( "positive regulation of motile cilium assembly") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +# Class: (protein localization to microtubule organizing center) + +AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GO_REF:0000087") Annotation( "PMID:19001497") "A process in which a protein is transported to, or maintained in, a location within a microtubule organizing center.") +AnnotationAssertion( "mah") +AnnotationAssertion( "2016-09-28T12:32:16Z") +AnnotationAssertion(Annotation( "GOC:TermGenie") "protein localisation in microtubule organizing center") +AnnotationAssertion(Annotation( "GOC:TermGenie") "protein localisation to microtubule organizing center") +AnnotationAssertion(Annotation( "GOC:TermGenie") "protein localization in microtubule organizing center") +AnnotationAssertion( "biological_process") +AnnotationAssertion( "GO:1905508") +AnnotationAssertion(rdfs:label "protein localization to microtubule organizing center") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) + # Class: (positive regulation of fertilization) AnnotationAssertion(Annotation( "GOC:TermGenie") Annotation( "GOC:hbye") Annotation( "GO_REF:0000058") Annotation( "PMID:27564576") "Any process that activates or increases the frequency, rate or extent of fertilization.") @@ -107762,21 +106233,6 @@ AnnotationAssertion( "regulation of protein localization to chromatin") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -# Class: (positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding) - -AnnotationAssertion(Annotation( "GOC:PARL") Annotation( "GOC:TermGenie") Annotation( "GOC:bc") Annotation( "GO_REF:0000059") Annotation( "PMID:23675531") "Any process that activates or increases the frequency, rate or extent of RNA polymerase II regulatory region sequence-specific DNA binding.") -AnnotationAssertion( "bc") -AnnotationAssertion( "2016-11-03T12:03:07Z") -AnnotationAssertion(Annotation( "GOC:TermGenie") "up regulation of RNA polymerase II regulatory region sequence-specific DNA binding") -AnnotationAssertion(Annotation( "GOC:TermGenie") "up-regulation of RNA polymerase II regulatory region sequence-specific DNA binding") -AnnotationAssertion(Annotation( "GOC:TermGenie") "upregulation of RNA polymerase II regulatory region sequence-specific DNA binding") -AnnotationAssertion(Annotation( "GOC:TermGenie") "activation of RNA polymerase II regulatory region sequence-specific DNA binding") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "GO:1905636") -AnnotationAssertion( ) -AnnotationAssertion(rdfs:label "positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) - # Class: (regulation of artery morphogenesis) AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:BHF_miRNA") Annotation( "GOC:TermGenie") Annotation( "GOC:rph") Annotation( "GO_REF:0000058") Annotation( "PMID:27389411") "Any process that modulates the frequency, rate or extent of artery morphogenesis.") @@ -108899,7 +107355,6 @@ EquivalentClasses( ObjectIntersection AnnotationAssertion(Annotation( "GOC:mtg_apoptosis") Annotation( "PMID:15558487") Annotation( "PMID:24664675") "Any apoptotic process in a retinal cell.") AnnotationAssertion( "pr") AnnotationAssertion( "2012-12-12T10:15:08Z") -AnnotationAssertion( "GO:0046674") AnnotationAssertion( "biological_process") AnnotationAssertion( "induction of retinal programmed cell death") AnnotationAssertion( "GO:1990009") @@ -109120,7 +107575,6 @@ SubClassOf( "PMID:9139127") "The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol.") AnnotationAssertion( "vw") AnnotationAssertion( "2014-12-04T09:48:12Z") -AnnotationAssertion( "GO:0010107") AnnotationAssertion( "potassium import") AnnotationAssertion( "potassium ion import") AnnotationAssertion(Annotation( "GOC:dph") Annotation( "GOC:tb") "potassium ion uptake") @@ -109294,29 +107748,6 @@ AnnotationAssertion(rdfs:label "prot EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) -# Class: (response to dsDNA) - -AnnotationAssertion(Annotation( "PMID:10051633") "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded DNA stimulus.") -AnnotationAssertion( "sl") -AnnotationAssertion( "2015-06-24T17:54:13Z") -AnnotationAssertion( "response to double-stranded DNA") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "GO:1990784") -AnnotationAssertion(rdfs:label "response to dsDNA") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) - -# Class: (cellular response to dsDNA) - -AnnotationAssertion(Annotation( "PMID:10051633") "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded DNA stimulus.") -AnnotationAssertion( "sl") -AnnotationAssertion( "2015-06-24T22:48:25Z") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "GO:1990786") -AnnotationAssertion(rdfs:label "cellular response to dsDNA") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) - # Class: (dorsal root ganglion development) AnnotationAssertion(Annotation( "PMID:18583150") "The process whose specific outcome is the progression of a dorsal root ganglion over time, from its formation to the mature structure.") @@ -109350,18 +107781,6 @@ AnnotationAssertion( "basic amino acid transmembrane transport") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -# Class: (sequence-specific double-stranded DNA binding) - -AnnotationAssertion(Annotation( "GOC:dos") Annotation( "GOC:sl") "Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.") -AnnotationAssertion( "sl") -AnnotationAssertion( "2015-08-25T17:30:06Z") -AnnotationAssertion( "sequence-specific dsDNA binding") -AnnotationAssertion( "molecular_function") -AnnotationAssertion( "GO:1990837") -AnnotationAssertion(rdfs:label "sequence-specific double-stranded DNA binding") -SubClassOf( ) -SubClassOf( ) - # Class: (adaptive thermogenesis) AnnotationAssertion(Annotation( "PMID:17260010") Annotation( "PMID:20363363") "The regulated production of heat in response to short term environmental changes, such as stress, diet or reduced temperature.") @@ -109418,8 +107837,6 @@ SubClassOf( "GOC:krc") Annotation( "GOC:vesicles") "A macromolecular complex that contains both RNA and protein molecules.") AnnotationAssertion( "pr") AnnotationAssertion( "2015-11-19T12:26:37Z") -AnnotationAssertion( "GO:0030529") -AnnotationAssertion( "GO:1990903") AnnotationAssertion( "Wikipedia:Ribonucleoprotein") AnnotationAssertion( "RNA-protein complex") AnnotationAssertion( "RNP") @@ -110225,7 +108642,6 @@ AnnotationAssertion( "negative regulation of glutamate metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) -SubClassOf( ) # Class: (positive regulation of glutamate metabolic process) @@ -110240,7 +108656,6 @@ AnnotationAssertion( "positive regulation of glutamate metabolic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ) -SubClassOf( ) # Class: (regulation of testosterone biosynthetic process) @@ -110497,19 +108912,20 @@ AnnotationAssertion( "negative regulation of DNA biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -# Class: (regulation of cellular amino acid biosynthetic process) +# Class: (regulation of amino acid biosynthetic process) AnnotationAssertion(Annotation( "GOC:obol") "Any process that modulates the frequency, rate or extent of cellular amino acid biosynthetic process.") +AnnotationAssertion( "https://github.com/geneontology/go-ontology/issues/28908"^^xsd:anyURI) AnnotationAssertion( "vw") AnnotationAssertion( "2010-12-10T11:54:19Z") -AnnotationAssertion(Annotation( "GOC:obol") "regulation of amino acid biosynthetic process") AnnotationAssertion(Annotation( "GOC:obol") "regulation of cellular amino acid anabolism") AnnotationAssertion(Annotation( "GOC:obol") "regulation of cellular amino acid biosynthesis") +AnnotationAssertion(Annotation( "GOC:obol") "regulation of cellular amino acid biosynthetic process") AnnotationAssertion(Annotation( "GOC:obol") "regulation of cellular amino acid formation") AnnotationAssertion(Annotation( "GOC:obol") "regulation of cellular amino acid synthesis") AnnotationAssertion( "biological_process") AnnotationAssertion( "GO:2000282") -AnnotationAssertion(rdfs:label "regulation of cellular amino acid biosynthetic process") +AnnotationAssertion(rdfs:label "regulation of amino acid biosynthetic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) # Class: (negative regulation of amino acid biosynthetic process) @@ -110732,39 +109148,6 @@ AnnotationAssertion(rdfs:label "posi EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) SubClassOf( ObjectSomeValuesFrom( )) -# Class: (regulation of glucocorticoid receptor signaling pathway) - -AnnotationAssertion(Annotation( "GOC:BHF") "Any process that modulates the frequency, rate or extent of glucocorticoid receptor signaling pathway.") -AnnotationAssertion( "vk") -AnnotationAssertion( "2011-01-18T04:38:10Z") -AnnotationAssertion(Annotation( "GOC:obol") "regulation of glucocorticoid receptor signalling pathway") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "GO:2000322") -AnnotationAssertion(rdfs:label "regulation of glucocorticoid receptor signaling pathway") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) - -# Class: (negative regulation of glucocorticoid receptor signaling pathway) - -AnnotationAssertion(Annotation( "GOC:BHF") "Any process that stops, prevents or reduces the frequency, rate or extent of glucocorticoid receptor signaling pathway.") -AnnotationAssertion( "vk") -AnnotationAssertion( "2011-01-18T04:38:43Z") -AnnotationAssertion(Annotation( "GOC:obol") "negative regulation of glucocorticoid receptor signalling pathway") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "GO:2000323") -AnnotationAssertion(rdfs:label "negative regulation of glucocorticoid receptor signaling pathway") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) - -# Class: (positive regulation of glucocorticoid receptor signaling pathway) - -AnnotationAssertion(Annotation( "GOC:BHF") "Any process that activates or increases the frequency, rate or extent of glucocorticoid receptor signaling pathway.") -AnnotationAssertion( "vk") -AnnotationAssertion( "2011-01-18T04:39:05Z") -AnnotationAssertion(Annotation( "GOC:obol") "positive regulation of glucocorticoid receptor signalling pathway") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "GO:2000324") -AnnotationAssertion(rdfs:label "positive regulation of glucocorticoid receptor signaling pathway") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) - # Class: (regulation of terminal button organization) AnnotationAssertion(Annotation( "GOC:BHF") Annotation( "GOC:mah") "Any process that modulates the frequency, rate or extent of terminal button organization.") @@ -111920,7 +110303,7 @@ AnnotationAssertion( "GO:2000609") AnnotationAssertion(rdfs:label "regulation of thyroid hormone generation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) +SubClassOf( ) SubClassOf( ) # Class: (negative regulation of thyroid hormone generation) @@ -111932,7 +110315,7 @@ AnnotationAssertion( "GO:2000610") AnnotationAssertion(rdfs:label "negative regulation of thyroid hormone generation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) +SubClassOf( ) SubClassOf( ) SubClassOf( ) @@ -111945,7 +110328,7 @@ AnnotationAssertion( "GO:2000611") AnnotationAssertion(rdfs:label "positive regulation of thyroid hormone generation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) +SubClassOf( ) SubClassOf( ) SubClassOf( ) @@ -112172,39 +110555,6 @@ AnnotationAssertion( "positive regulation of type B pancreatic cell apoptotic process") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -# Class: (regulation of transcription regulatory region DNA binding) - -AnnotationAssertion(Annotation( "GOC:obol") "Any process that modulates the frequency, rate or extent of transcription regulatory region DNA binding.") -AnnotationAssertion( "yaf") -AnnotationAssertion( "2011-05-09T03:28:11Z") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "GO:2000677") -AnnotationAssertion( ) -AnnotationAssertion(rdfs:label "regulation of transcription regulatory region DNA binding") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) - -# Class: (negative regulation of transcription regulatory region DNA binding) - -AnnotationAssertion(Annotation( "GOC:obol") "Any process that stops, prevents or reduces the frequency, rate or extent of transcription regulatory region DNA binding.") -AnnotationAssertion( "yaf") -AnnotationAssertion( "2011-05-09T03:28:14Z") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "GO:2000678") -AnnotationAssertion( ) -AnnotationAssertion(rdfs:label "negative regulation of transcription regulatory region DNA binding") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) - -# Class: (positive regulation of transcription regulatory region DNA binding) - -AnnotationAssertion(Annotation( "GOC:obol") "Any process that activates or increases the frequency, rate or extent of transcription regulatory region DNA binding.") -AnnotationAssertion( "yaf") -AnnotationAssertion( "2011-05-09T03:28:17Z") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "GO:2000679") -AnnotationAssertion( ) -AnnotationAssertion(rdfs:label "positive regulation of transcription regulatory region DNA binding") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) - # Class: (regulation of cardiac muscle cell myoblast differentiation) AnnotationAssertion(Annotation( "GOC:obol") "Any process that modulates the frequency, rate or extent of cardiac muscle cell myoblast differentiation.") @@ -112537,18 +110887,6 @@ AnnotationAssertion( "negative regulation of myoblast proliferation") EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -# Class: (positive regulation of androgen receptor activity) - -AnnotationAssertion(Annotation( "GOC:obol") "Any process that activates or increases the frequency, rate or extent of androgen receptor activity.") -AnnotationAssertion( "yaf") -AnnotationAssertion( "2011-07-15T10:56:14Z") -AnnotationAssertion( "biological_process") -AnnotationAssertion( "GO:2000825") -AnnotationAssertion( ) -AnnotationAssertion(rdfs:label "positive regulation of androgen receptor activity") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ObjectSomeValuesFrom( )) - # Class: (regulation of heart morphogenesis) AnnotationAssertion(Annotation( "GOC:BHF") "Any process that modulates the frequency, rate or extent of heart morphogenesis.") @@ -113710,7 +112048,6 @@ SubClassOf( (information content entity) AnnotationAssertion(rdfs:label "information content entity"@en) -SubClassOf( ) # Class: (curation status specification) @@ -113773,7 +112110,6 @@ SubClassOf( (Mus musculus) -AnnotationAssertion( "NCBITaxon:85055") AnnotationAssertion( "GC_ID:1") AnnotationAssertion(Annotation( ) "house mouse") AnnotationAssertion(Annotation( ) "mouse") @@ -113792,7 +112128,6 @@ SubClassOf( (Euteleostomi) -AnnotationAssertion( "NCBITaxon:40673") AnnotationAssertion( "GC_ID:1") AnnotationAssertion(Annotation( ) "bony vertebrates") AnnotationAssertion( "ncbi_taxonomy") @@ -113802,7 +112137,6 @@ SubClassOf( (Chromadorea) -AnnotationAssertion( "NCBITaxon:27837") AnnotationAssertion( "GC_ID:1") AnnotationAssertion( "ncbi_taxonomy") AnnotationAssertion(Annotation( ) "Adenophorea") @@ -114535,7 +112869,6 @@ DisjointClasses( (Murinae) -AnnotationAssertion( "NCBITaxon:109679") AnnotationAssertion( "GC_ID:1") AnnotationAssertion( "ncbi_taxonomy") AnnotationAssertion( "NCBITaxon:39107") @@ -114663,8 +112996,6 @@ SubClassOf( (Saccharomycetaceae) -AnnotationAssertion( "NCBITaxon:221665") -AnnotationAssertion( "NCBITaxon:44280") AnnotationAssertion( "GC_ID:1") AnnotationAssertion( "ncbi_taxonomy") AnnotationAssertion( "NCBITaxon:4893") @@ -114691,7 +113022,6 @@ SubClassOf( (Schizosaccharomyces pombe) -AnnotationAssertion( "NCBITaxon:45042") AnnotationAssertion( "GC_ID:1") AnnotationAssertion(Annotation( ) "fission yeast") AnnotationAssertion( "ncbi_taxonomy") @@ -114702,7 +113032,6 @@ SubClassOf( (Saccharomyces) -AnnotationAssertion( "NCBITaxon:36915") AnnotationAssertion( "GC_ID:1") AnnotationAssertion( "ncbi_taxonomy") AnnotationAssertion(Annotation( ) "Pachytichospora") @@ -114712,8 +113041,6 @@ SubClassOf( (Saccharomyces cerevisiae) -AnnotationAssertion( "NCBITaxon:2898199") -AnnotationAssertion( "NCBITaxon:41870") AnnotationAssertion( "GC_ID:1") AnnotationAssertion(Annotation( ) "Saccharomyces cerevisiae 'var. diastaticus'") AnnotationAssertion(Annotation( ) "baker's yeast") @@ -114845,8 +113172,6 @@ DisjointClasses( (Rhabditida) -AnnotationAssertion( "NCBITaxon:33251") -AnnotationAssertion( "NCBITaxon:6308") AnnotationAssertion( "GC_ID:1") AnnotationAssertion( "ncbi_taxonomy") AnnotationAssertion(Annotation( ) "Strongylida") @@ -114864,7 +113189,6 @@ SubClassOf( (Rhabditidae) -AnnotationAssertion( "NCBITaxon:54603") AnnotationAssertion( "GC_ID:1") AnnotationAssertion( "ncbi_taxonomy") AnnotationAssertion( "NCBITaxon:6243") @@ -115079,7 +113403,6 @@ SubClassOf( (Callithrix ) -AnnotationAssertion( "NCBITaxon:9492") AnnotationAssertion( "GC_ID:1") AnnotationAssertion(Annotation( ) "Callithrix") AnnotationAssertion( "ncbi_taxonomy") @@ -115089,7 +113412,6 @@ SubClassOf( (Callithrix jacchus) -AnnotationAssertion( "NCBITaxon:9484") AnnotationAssertion( "GC_ID:1") AnnotationAssertion(Annotation( ) "common marmoset") AnnotationAssertion(Annotation( ) "white ear-tufted marmoset") @@ -115164,7 +113486,6 @@ SubClassOf( (Felis catus) -AnnotationAssertion( "NCBITaxon:36475") AnnotationAssertion( "GC_ID:1") AnnotationAssertion( "PMID:17600185") AnnotationAssertion( "PMID:8581300") @@ -115200,13 +113521,6 @@ SubClassOf( (Equus) -AnnotationAssertion( "NCBITaxon:1225530") -AnnotationAssertion( "NCBITaxon:35506") -AnnotationAssertion( "NCBITaxon:35507") -AnnotationAssertion( "NCBITaxon:35508") -AnnotationAssertion( "NCBITaxon:35509") -AnnotationAssertion( "NCBITaxon:35510") -AnnotationAssertion( "NCBITaxon:475184") AnnotationAssertion( "GC_ID:1") AnnotationAssertion( "ncbi_taxonomy") AnnotationAssertion(Annotation( ) "Amerhippus") @@ -115239,7 +113553,6 @@ SubClassOf( (quality) AnnotationAssertion(Annotation( "PATOC:GVG") "A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities") -AnnotationAssertion( "PATO:0000072") AnnotationAssertion( "quality") AnnotationAssertion( "PATO:0000001") AnnotationAssertion(rdfs:label "quality") @@ -115248,7 +113561,6 @@ SubClassOf( (composition) AnnotationAssertion(Annotation( "PATOC:GVG") "A single physical entity inhering in an bearer by virtue of the bearer's quantities or relative ratios of subparts.") -AnnotationAssertion( "PATO:0002015") AnnotationAssertion( "composed of") AnnotationAssertion( "compositionality") AnnotationAssertion( "content") @@ -115282,7 +113594,6 @@ SubClassOf( (shape) AnnotationAssertion(Annotation( "PATOC:GVG") "A morphological quality inhering in a bearer by virtue of the bearer's ratios of distances between its features (points, edges, surfaces and also holes etc).") -AnnotationAssertion( "PATO:0001647") AnnotationAssertion( "relational shape quality") AnnotationAssertion( "quality") AnnotationAssertion( "PATO:0000052") @@ -115331,7 +113642,6 @@ SubClassOf( (structure) AnnotationAssertion(Annotation( "PATOC:GVG") "A morphology quality inhering in a bearer by virtue of the bearer's relative position, shape, arrangements and connectivity of an organism's various parts; the pattern underlying its form.") -AnnotationAssertion( "PATO:0001452") AnnotationAssertion(Annotation( "VT:1000738") "conformation") AnnotationAssertion( "relational structural quality") AnnotationAssertion( "quality") @@ -115384,7 +113694,6 @@ SubClassOf( (coiled) AnnotationAssertion(Annotation( "WordNet:WordNet") "A shape quality inhering in a bearer by virtue of the bearer's being curled or wound (especially in concentric rings or spirals).") -AnnotationAssertion( "PATO:0001363") AnnotationAssertion( "spiral") AnnotationAssertion( "quality") AnnotationAssertion( "helical") @@ -115464,7 +113773,6 @@ SubClassOf( (increased size) AnnotationAssertion(Annotation( "PATOC:GVG") "A size quality which is relatively high.") -AnnotationAssertion( "PATO:0001202") AnnotationAssertion( "quality") AnnotationAssertion( "big") AnnotationAssertion( "enlarged") @@ -115598,7 +113906,6 @@ SubClassOf( (physical quality) AnnotationAssertion(Annotation( "PATOC:GVG") "A quality of a physical entity that exists through action of continuants at the physical level of organisation in relation to other entities.") -AnnotationAssertion( "PATO:0002079") AnnotationAssertion( "Wikipedia:Physical_property") AnnotationAssertion( "relational physical quality") AnnotationAssertion( "quality") @@ -115651,8 +113958,6 @@ SubClassOf( (physical object quality) AnnotationAssertion(Annotation( "PATOC:GVG") "A quality which inheres in a continuant.") -AnnotationAssertion( "PATO:0001237") -AnnotationAssertion( "PATO:0001238") AnnotationAssertion( "snap:Quality") AnnotationAssertion( "monadic quality of a continuant") AnnotationAssertion( "multiply inhering quality of a physical entity") @@ -116189,7 +114494,6 @@ SubClassOf( (cylindrical) AnnotationAssertion(Annotation( "PATOC:MAH") "A convex 3-D shape quality inhering in a bearer by virtue of the bearer's exhibiting a consistently-sized round cross section.") -AnnotationAssertion( "PATO:0001203") AnnotationAssertion( "rod-like") AnnotationAssertion( "rod-shaped") AnnotationAssertion( "tubulate") @@ -117321,10 +115625,10 @@ AnnotationAssertion(Annotation( "IEDB:BP") "native protein") AnnotationAssertion( "protein") AnnotationAssertion( "PR:000000001") -AnnotationAssertion(rdfs:comment "The definition above excludes protein complexes, which some also consider a protein. Those who wish to refer to a class representing both senses of the word are directed to CHEBI:36080. Note that the definition allows for experimentally-manipulated genes, and allows for artifically-produced derivatives that mimic those found naturally. Proteins (in the sense defined here) that descended from a common ancestor can be classified into families and superfamilies composed of products of evolutionarily-related genes. The domain architecture of a protein is described by the order of its constituent domains. Proteins with the same domains in the same order are defined as homeomorphic [PRO:WCB).") +AnnotationAssertion(rdfs:comment "The definition above excludes protein complexes, which some also consider a protein. Those who wish to refer to a class representing both senses of the word are directed to CHEBI:36080. Note that the definition allows for experimentally-manipulated genes, and allows for artifically-produced derivatives that mimic those found naturally. Proteins (in the sense defined here) that descended from a common ancestor can be classified into families and superfamilies composed of products of evolutionarily-related genes. The domain architecture of a protein is described by the order of its constituent domains. Proteins with the same domains in the same order are defined as homeomorphic [PRO:WCB].") AnnotationAssertion(rdfs:label "protein") SubClassOf( ) -SubClassOf( ) +SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) SubClassOf( ObjectSomeValuesFrom( )) @@ -118907,6 +117211,7 @@ SubClassOf( (prominin) AnnotationAssertion(Annotation( "InterPro:IPR008795") Annotation( "PMID:11467842") "A protein with core architecture consisting of one Prominin (Pfam:PF05478) domain. The prominins are an emerging family of proteins that, among the multispan membrane proteins, display a novel topology. Mouse and human prominin and prominin-like 1 are predicted to contain five membrane spanning domains, with an N-terminal domain exposed to the extracellular space followed by four, alternating small cytoplasmic and large extracellular, loops and a cytoplasmic C-terminal domain.") +AnnotationAssertion( "PANTHER:PTHR22730") AnnotationAssertion( "PIRSF:PIRSF017831") AnnotationAssertion( "protein") AnnotationAssertion( "PR:000001785") @@ -122674,20 +120979,20 @@ SubClassOf( ) SubClassOf( ObjectSomeValuesFrom( )) -# Class: (protein-containing molecular entity) - -AnnotationAssertion(Annotation( "PRO:DAN") "A molecular entity that minimally consists of a protein.") -AnnotationAssertion(Annotation( "PRO:DAN") "protein") -AnnotationAssertion(Annotation( "PRO:DAN") "protein aggregate") -AnnotationAssertion(Annotation( "PRO:DAN") "protein complex") -AnnotationAssertion(Annotation( "PRO:DAN") "protein-containing complex") -AnnotationAssertion( "protein") -AnnotationAssertion( "PR:000064867") -AnnotationAssertion(rdfs:comment "Note: This includes single proteins and derivatives thereof (PR:000000001), protein-containing complexes (GO:0032991), and protein aggregates (PR:000050565).") -AnnotationAssertion(rdfs:label "protein-containing molecular entity") -EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) -SubClassOf( ) -SubClassOf( ObjectSomeValuesFrom( )) +# Class: (protein-containing material entity) + +AnnotationAssertion(Annotation( "PRO:DAN") "A material entity that minimally consists of a protein.") +AnnotationAssertion(Annotation( "PRO:DAN") "protein") +AnnotationAssertion(Annotation( "PRO:DAN") "protein aggregate") +AnnotationAssertion(Annotation( "PRO:DAN") "protein complex") +AnnotationAssertion(Annotation( "PRO:DAN") "protein-containing complex") +AnnotationAssertion( "protein") +AnnotationAssertion( "PR:000050567") +AnnotationAssertion(rdfs:comment "Note: This includes single proteins and derivatives thereof (PR:000000001), protein-containing complexes (GO:0032991), and protein aggregates (PR:000050566).") +AnnotationAssertion(rdfs:label "protein-containing material entity") +EquivalentClasses( ObjectIntersectionOf( ObjectSomeValuesFrom( ))) +SubClassOf( ) +SubClassOf( ObjectSomeValuesFrom( )) # Class: (SCO-spondin (human)) @@ -122943,7 +121248,7 @@ SubClassOf( ObjectSomeValuesFrom( (natural killer cells antigen CD94 (mouse)) -AnnotationAssertion(Annotation( "OMA:O54707") Annotation( "PRO:DNx") "A killer cell lectin-like receptor subfamily D member 1 that is encoded in the genome of mouse.") +AnnotationAssertion(Annotation( "OMA:O54707") Annotation( "PANTHER:PTHR22800:SF15") Annotation( "PRO:DNx") "A killer cell lectin-like receptor subfamily D member 1 that is encoded in the genome of mouse.") AnnotationAssertion( "UniProtKB:O54707") AnnotationAssertion(Annotation( "UniProtKB:O54707") "CD94 (mouse)") AnnotationAssertion(Annotation( "UniProtKB:O54707") "killer cell lectin-like receptor subfamily D member 1 (mouse)") @@ -123044,7 +121349,7 @@ SubClassOf( ObjectSomeValuesFrom( (CD83 antigen (mouse)) -AnnotationAssertion(Annotation( "OMA:O88324") Annotation( "PRO:DNx") "A CD83 molecule that is encoded in the genome of mouse.") +AnnotationAssertion(Annotation( "OMA:O88324") Annotation( "PANTHER:PTHR15193:SF0") Annotation( "PRO:DNx") "A CD83 molecule that is encoded in the genome of mouse.") AnnotationAssertion( "UniProtKB:O88324") AnnotationAssertion(Annotation( "UniProtKB:O88324") "CD83 (mouse)") AnnotationAssertion(Annotation( "PRO:DNx") Annotation( ) "mCD83") @@ -123142,7 +121447,6 @@ SubClassOf( ObjectSomeValuesFrom( (eomesodermin homolog (human)) AnnotationAssertion(Annotation( "PRO:CNA") Annotation( "UniProtKB:O95936") "An eomesodermin that is encoded in the genome of human.") -AnnotationAssertion(Annotation(rdfs:label "PR:O95936 located_in GO:0005654") "Reactome:R-HSA-452232") AnnotationAssertion( "UniProtKB:O95936") AnnotationAssertion(Annotation( "UniProtKB:O95936") "T-box brain protein 2 (human)") AnnotationAssertion(Annotation( "UniProtKB:O95936") "T-brain-2 (human)") @@ -127025,7 +125329,7 @@ AnnotationAssertion(Annotation( "ADP-ribosyl cyclase 1 (human)") AnnotationAssertion(Annotation( "UniProtKB:P28907") "ADPRC 1 (human)") AnnotationAssertion(Annotation( "UniProtKB:P28907") "T10 (human)") -AnnotationAssertion(Annotation( "UniProtKB:P28907") "cADPR hydrolase 1 (human)") +AnnotationAssertion(Annotation( "UniProtKB:P28907") "cADPr hydrolase 1 (human)") AnnotationAssertion(Annotation( "UniProtKB:P28907") "cyclic ADP-ribose hydrolase 1 (human)") AnnotationAssertion(Annotation( "PRO:DNx") Annotation( ) "hCD38") AnnotationAssertion( "protein") @@ -128484,7 +126788,7 @@ AnnotationAssertion(Annotation( "UniProtKB:P56528") "CD38 (mouse)") AnnotationAssertion(Annotation( "UniProtKB:P56528") "I-19 (mouse)") AnnotationAssertion(Annotation( "UniProtKB:P56528") "NIM-R5 antigen (mouse)") -AnnotationAssertion(Annotation( "UniProtKB:P56528") "cADPR hydrolase 1 (mouse)") +AnnotationAssertion(Annotation( "UniProtKB:P56528") "cADPr hydrolase 1 (mouse)") AnnotationAssertion(Annotation( "UniProtKB:P56528") "cyclic ADP-ribose hydrolase 1 (mouse)") AnnotationAssertion(Annotation( "PRO:DNx") Annotation( ) "mCD38") AnnotationAssertion( "protein") @@ -132519,7 +130823,6 @@ SubClassOf( ObjectSomeValuesFrom( AnnotationAssertion(Annotation( "BIRNLEX:2596") "Sensory ganglia located on the dorsal spinal roots within the vertebral column. The spinal ganglion cells are pseudounipolar. The single primary branch bifurcates sending a peripheral process to carry sensory information from the periphery and a central branch which relays that information to the spinal cord or brain. (MSH) * ganglion found on the posterior root of each spinal nerve, composed of the unipolar nerve cell bodies of the sensory neurons of the nerve. (CSP).") AnnotationAssertion( ) -AnnotationAssertion( "UBERON:0026602") AnnotationAssertion( "AAO:0011032") AnnotationAssertion( "BIRNLEX:2596") AnnotationAssertion( "BIRNLEX:2598") @@ -132905,7 +131208,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (anatomical wall) AnnotationAssertion(Annotation( "FMA:82482") "Organ component adjacent to an organ cavity and which consists of a maximal aggregate of organ component layers.") -AnnotationAssertion( "UBERON:0009915") AnnotationAssertion( "wall") AnnotationAssertion( "FMA:82482") AnnotationAssertion( "galen:Wall") @@ -133252,7 +131554,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (subdivision of skeletal system) AnnotationAssertion(Annotation( "UBERONREF:0000003") Annotation( "https://orcid.org/0000-0002-6601-2165") "Anatomical cluster consisting of the skeletal elements and articular elements that are part of an individual subdivision of the organism.") -AnnotationAssertion( "UBERON:0010322") AnnotationAssertion( "FMA:85544") AnnotationAssertion( "NCIT:C34076") AnnotationAssertion( "SCTID:118966000") @@ -134157,7 +132458,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (neuron projection bundle) AnnotationAssertion(Annotation( "CARO:0001001") Annotation( "FBC:DOS") Annotation( "FBbt:00005099") "A fasciculated bundle of neuron projections (GO:0043005), largely or completely lacking synapses.") -AnnotationAssertion( "UBERON:0005163") AnnotationAssertion( "CARO:0001001") AnnotationAssertion(Annotation( ) "FBbt:00005099") AnnotationAssertion( "NLX:147821") @@ -134323,7 +132623,6 @@ SubClassOf( ObjectSomeValuesFrom( AnnotationAssertion(Annotation( "Wikipedia:Theca_externa") "The theca externa is the outer layers of the theca folliculi. It contains abundant collagen and is mainly supportive.") AnnotationAssertion( ) -AnnotationAssertion( "UBERON:0005182") AnnotationAssertion( "BTO:0002852") AnnotationAssertion( "FMA:18657") AnnotationAssertion( "MA:0001713") @@ -134351,7 +132650,6 @@ SubClassOf( ObjectSomeValuesFrom( AnnotationAssertion(Annotation( "Wikipedia:Theca_externa#Theca_interna") "Theca interna cells express receptors for luteinizing hormone, which when activated will stimulate the production of androstenedione from cholesterol by the enzyme desmolase. Androstenedione ultimately gives the granulosa cells the precursor substrate for estrogen manufacturing.") AnnotationAssertion( ) -AnnotationAssertion( "UBERON:0005183") AnnotationAssertion( "BTO:0002851") AnnotationAssertion( "FMA:18658") AnnotationAssertion( "MA:0001714") @@ -134760,8 +133058,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (excreta) AnnotationAssertion(Annotation( "GO:0007588") Annotation( "http://orcid.org/0000-0002-6601-2165") "A portion of organism substance that is the product of an excretion process that will be eliminated from the body. An excretion process is elimination by an organism of the waste products that arise as a result of metabolic activity.") -AnnotationAssertion( "UBERON:0000324") -AnnotationAssertion( "UBERON:0007550") AnnotationAssertion( "AEO:0000184") AnnotationAssertion( "BTO:0000491") AnnotationAssertion( "EHDAA2_RETIRED:0003184") @@ -134902,7 +133198,6 @@ AnnotationAssertion(Annotation( "PMID:8932866") ) AnnotationAssertion( ) AnnotationAssertion( "2009-04-18T12:03:09Z") -AnnotationAssertion( "UBERON:0007333") AnnotationAssertion( "BTO:0003399") AnnotationAssertion( "DMBA:15903") AnnotationAssertion( "EFO:0003534") @@ -135130,7 +133425,6 @@ SubClassOf(Annotation( "ISB AnnotationAssertion(Annotation( "Wikipedia:Blastula") "Organism at the blastula stage - an early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence.") AnnotationAssertion( "TODO - check relationship with epiblast. Note in FMA this is not a subclass of embryo, but in uberon embryo is the whole organism from zygote onwards and thus includes the blastula") -AnnotationAssertion( "UBERON:0007011") AnnotationAssertion( "BILA:0000059") AnnotationAssertion( "BTO:0000128") AnnotationAssertion( "GAID:1294") @@ -135295,8 +133589,6 @@ SubClassOf( ObjectSomeValuesFrom( AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Mucosa that is part of a colon. The mucosa of the colon is lined by a simple columnar epithelium with a thin brush border and numerous goblet cells.") AnnotationAssertion( ) -AnnotationAssertion( "UBERON:0003347") -AnnotationAssertion( "UBERON:0004981") AnnotationAssertion( "BTO:0000271") AnnotationAssertion( "CALOHA:TS-0164") AnnotationAssertion( "EFO:0003038") @@ -135325,7 +133617,6 @@ SubClassOf( ObjectSomeValuesFrom( AnnotationAssertion(Annotation( "OBOL:automatic") "A mucosa that is part of a duodenum [Automatically generated definition].") AnnotationAssertion( ) -AnnotationAssertion( "UBERON:0003348") AnnotationAssertion( "BTO:0000367") AnnotationAssertion( "CALOHA:TS-0213") AnnotationAssertion( "EMAPA:27235") @@ -135688,7 +133979,6 @@ DisjointClasses( (pharyngeal mucosa) AnnotationAssertion(Annotation( "OBOL:automatic") "A mucosa that is part of a pharynx [Automatically generated definition].") -AnnotationAssertion( "UBERON:0003344") AnnotationAssertion( "BTO:0001047") AnnotationAssertion( "EMAPA:26957") AnnotationAssertion( "FMA:55031") @@ -135838,7 +134128,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (corpus striatum) AnnotationAssertion(Annotation( "Wikipedia:Corpus_striatum") "The corpus striatum (striated body) is a compound structure consisting of the caudate nucleus and the lentiform nucleus, which consists of the putamen and the globus pallidus[WP].") -AnnotationAssertion( "UBERON:0010082") AnnotationAssertion( "BAMS:CSTR") AnnotationAssertion( "BTO:0001311") AnnotationAssertion( "CALOHA:TS-0183") @@ -136595,7 +134884,6 @@ SubClassOf(Annotation( "MGI # Class: (gastric pit) AnnotationAssertion(Annotation( "Wikipedia:Gastric_pits") "Gastric pits are indentations in the stomach which denote entrances to the gastric glands. They are deeper in the pylorus than they are in the other parts of the stomach. The human stomach has several million of these pits.") -AnnotationAssertion( "UBERON:0000425") AnnotationAssertion( "BTO:0002364") AnnotationAssertion( "FMA:62947") AnnotationAssertion( "NCIT:C32659") @@ -136618,7 +134906,6 @@ SubClassOf(Annotation( "BTO AnnotationAssertion(Annotation( "MP:0001168") "The prostate epithelium.") AnnotationAssertion( "TODO - check 2 FMA IDs") AnnotationAssertion( ) -AnnotationAssertion( "UBERON:0002452") AnnotationAssertion( "BTO:0002397") AnnotationAssertion( "CALOHA:TS-2065") AnnotationAssertion( "EMAPA:35711") @@ -136654,7 +134941,6 @@ SubClassOf( ObjectSomeValuesFrom( AnnotationAssertion(Annotation( "BTO:0002437") "A plexus of autonomic nerve fibers within the wall of the digestive tube, and made up of the submucosal, myenteric, and subserosal plexuses; it contains visceral afferent fibers, sympathetic postganglionic fibers, parasympathetic preganglionic and postganglionic fibers, and parasympathetic postganglionic cell bodies.") AnnotationAssertion( ) -AnnotationAssertion( "UBERON:0012372") AnnotationAssertion( "BTO:0002437") AnnotationAssertion( "EMAPA:35446") AnnotationAssertion( "FMA:77597") @@ -136840,7 +135126,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (secretion of exocrine gland) AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A portion of organism substance that is produced by exocrine glands.") -AnnotationAssertion( "UBERON:0006540") AnnotationAssertion(Annotation( "FMA:9675") "secretion") AnnotationAssertion( "AEO:0001005") AnnotationAssertion( "BTO:0002977") @@ -137170,7 +135455,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (testis) AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A gonad of a male animal. A gonad produces and releases sperm.") -AnnotationAssertion( "UBERON:0002117") AnnotationAssertion( "AAO:0000606") AnnotationAssertion( "BILA:0000124") AnnotationAssertion( "BSA:0000085") @@ -137953,7 +136237,6 @@ SubClassOf(Annotation( "Bge AnnotationAssertion(Annotation( "Wikipedia:Mesoderm") "The middle germ layer of the embryo, between the endoderm and ectoderm.") AnnotationAssertion( ) -AnnotationAssertion( "UBERON:0003263") AnnotationAssertion( "AAO:0000304") AnnotationAssertion( "BILA:0000037") AnnotationAssertion( "BTO:0000839") @@ -141024,7 +139307,6 @@ AnnotationAssertion(rdfs:label " AnnotationAssertion(Annotation( "Wikipedia:Pancreatic_duct") "A duct joining the pancreas to the common bile duct to supply pancreatic juices which aid in digestion provided by the exocrine pancreas. The pancreatic duct joins the common bile duct just prior to the ampulla of Vater, after which both ducts perforate the medial side of the second portion of the duodenum at the major duodenal papilla.") AnnotationAssertion( ) -AnnotationAssertion( "UBERON:0005627") AnnotationAssertion(Annotation( "MESH:A03.734.667") "pancreatic duct") AnnotationAssertion( "BTO:0002362") AnnotationAssertion( "EHDAA2:0001396") @@ -141692,7 +139974,6 @@ SubClassOf(Annotation( "FMA AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Any vertebral bone that is part of the caudal region of the vertebral column (tail or coccyx).") AnnotationAssertion( ) -AnnotationAssertion( "UBERON:0006070") AnnotationAssertion(Annotation( "FMA:12527") Annotation( ) "caudal vertebra") AnnotationAssertion( "EMAPA:18374") AnnotationAssertion( "FMA:12527") @@ -142199,7 +140480,6 @@ SubClassOf(Annotation( "Wik AnnotationAssertion(Annotation( "ZFA:0005280") "Muscle tissue composed of cardiac muscle cells, forming the muscles of the heart[ZFA,modified].") AnnotationAssertion( "check relationship with myocardium. part_of in MA - but we also have a more specific class 'cardiac muscle tissue of myocardium'. Check ncit") -AnnotationAssertion( "UBERON:0007096") AnnotationAssertion( "AAO:0010245") AnnotationAssertion( "AEO:0000142") AnnotationAssertion( "BILA:0000134") @@ -143017,7 +141297,6 @@ SubClassOf(Annotation( "FMA AnnotationAssertion(Annotation( "BTO:0000198") Annotation( "Wikipedia:Cardia") "The part of the stomach attached to the esophagus. The cardia begins immediately distal to the z-line of the gastroeosphageal junction, where the squamous epithelium of the esophagus gives way to the columnar epithelium of the gastrointestinal tract[WP].") AnnotationAssertion( "There were previously conflicting statements in the academic anatomy community[10][11][12] over whether the cardia is part of the stomach, part of the esophagus or a distinct entity. Modern surgical and medical textbooks have agreed that 'The gastric cardia is now clearly considered to be part of the stomach'[13][14]. Classical anatomy textbooks, and some other resources[15], describe the cardia as the first of 4 regions of the stomach. This makes sense histologically because the mucosa of the cardia is the same as that of the stomach[WP]") AnnotationAssertion( "We follow Kardong in defining stomach regions by glands.") -AnnotationAssertion( "UBERON:0004712") AnnotationAssertion( "BTO:0000198") AnnotationAssertion( "EMAPA:35811") AnnotationAssertion( "FMA:14561") @@ -144214,7 +142493,6 @@ SubClassOf( ObjectSomeValuesFrom( AnnotationAssertion(Annotation( "MGI:csmith") Annotation( "MGI:rbabiuk") Annotation( "MP:0008108") "The tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold.") AnnotationAssertion( "in mammals, villi are (largely?) absent from the large intestine, so we treat this as equivalent to small intestinal villus. small/large subdivision may not make sense for all species for which this is present (see ZFA). Note that VHOG quotes ISBN:978-0030223693 as suggesting there are some villi in the large intestine") -AnnotationAssertion( "UBERON:0007607") AnnotationAssertion( "BTO:0003121") AnnotationAssertion( "EMAPA:35784") AnnotationAssertion( "FMA:15072") @@ -144591,7 +142869,6 @@ DisjointClasses( "GO:0072078") Annotation( "Wikipedia:Renal_tubule") "An epithelial tube that is part of the nephron, the functional part of the kidney.") AnnotationAssertion( ) -AnnotationAssertion( "UBERON:0004210") AnnotationAssertion( "renal tubule") AnnotationAssertion( "BTO:0000343") AnnotationAssertion( "CALOHA:TS-1262") @@ -145056,7 +143333,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (spleen lymphoid follicle) AnnotationAssertion(Annotation( "CL:tm") Annotation( "MP:0008470") Annotation( "https://github.com/obophenotype/uberon/issues/6") "The area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur.") -AnnotationAssertion( "UBERON:0003969") AnnotationAssertion( "EMAPA:35804") AnnotationAssertion( "MA:0002672") AnnotationAssertion( "NCIT:C33602") @@ -145848,7 +144124,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (liver parenchyma) AnnotationAssertion(Annotation( "MP:0008986") "The functional units of the liver including the lobules.") -AnnotationAssertion( "UBERON:0003223") AnnotationAssertion( "AAO:0010405") AnnotationAssertion( "EHDAA2:0001004") AnnotationAssertion( "EHDAA:2201") @@ -145879,7 +144154,6 @@ SubClassOf( ObjectSomeValuesFrom( AnnotationAssertion(Annotation( "Wikipedia:Hepatic_sinusoid") Annotation( "ZFIN:curator") "Wide thin-walled blood vessels in the liver. In mammals they have neither veinous or arterial markers.") AnnotationAssertion( ) -AnnotationAssertion( "UBERON:0003275") AnnotationAssertion( "EHDAA2:0000999") AnnotationAssertion( "EMAPA:17365") AnnotationAssertion( "FMA:17543") @@ -146123,7 +144397,6 @@ SubClassOf( ObjectSomeValuesFrom( AnnotationAssertion(Annotation( "GO:0072020") "The proximal straight tubule is the part of the descending limb that extends from the proximal convoluted tubule to the descending thin tubule.") AnnotationAssertion( "TODO - is S3 exactly coincident with PST? todo - ensure relationships work across species (loop of Henle)") AnnotationAssertion( ) -AnnotationAssertion( "UBERON:0005166") AnnotationAssertion( "BTO:0000055") AnnotationAssertion( "EMAPA:29661") AnnotationAssertion( "EMAPA:29669") @@ -147434,7 +145707,6 @@ SubClassOf(Annotation( "FMA # Class: (parietal peritoneum) AnnotationAssertion(Annotation( "Wikipedia:Peritoneum#Types") Annotation( "http://orcid.org/0000-0002-6601-2165") "The outer layer of peritoneum that is attached to the abdominal and pelvic walls.") -AnnotationAssertion( "UBERON:0004459") AnnotationAssertion( "AAO:0010816") AnnotationAssertion( "EMAPA:16591") AnnotationAssertion( "FMA:21451") @@ -147460,7 +145732,6 @@ SubClassOf( ObjectSomeValuesFrom( AnnotationAssertion(Annotation( "Wikipedia:Leg_muscle") Annotation( "https://orcid.org/0000-0002-6601-2165") "A muscle that is part of the region of the hindlimb between the pelvis and ankle.") AnnotationAssertion( ) -AnnotationAssertion( "UBERON:0003270") AnnotationAssertion( "BTO:0000722") AnnotationAssertion( "EHDAA:8291") AnnotationAssertion( "MA:0000672") @@ -148232,7 +146503,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (phalanx of pes) AnnotationAssertion(Annotation( "Wikipedia:Phalanges_of_the_foot") Annotation( "https://orcid.org/0000-0002-6601-2165") "A phalanx that is part of a hindlimb autopod[Automatically generated definition].") -AnnotationAssertion( "UBERON:0004272") AnnotationAssertion(Annotation( "OBOL:automatic") "digital bone of pes") AnnotationAssertion( "AAO:0000930") AnnotationAssertion( "EMAPA:32941") @@ -148491,7 +146761,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pedal digit) AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "A digit that is part of a pes (foot).") -AnnotationAssertion( "UBERON:0000027") AnnotationAssertion( "AAO:0000888") AnnotationAssertion( "BTO:0002348") AnnotationAssertion( "EMAPA:32649") @@ -149202,7 +147471,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (muscle of pelvic girdle) AnnotationAssertion(Annotation( "OBOL:automatic") "Any muscle organ that is part of a pelvic girdle [Automatically generated definition].") -AnnotationAssertion( "UBERON:0003271") AnnotationAssertion( "EHDAA:8326") AnnotationAssertion( "EMAPA:18185") AnnotationAssertion( "FMA:37367") @@ -149247,7 +147515,6 @@ SubClassOf(Annotation( "pro AnnotationAssertion(Annotation( "OBOL:automatic") "A muscle organ that is part of an arm [Automatically generated definition].") AnnotationAssertion( ) -AnnotationAssertion( "UBERON:0003272") AnnotationAssertion( "EHDAA:8277") AnnotationAssertion( "EMAPA:36053") AnnotationAssertion( "MA:0000594") @@ -149500,7 +147767,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (skin of elbow) AnnotationAssertion(Annotation( "OBOL:automatic") "A zone of skin that is part of a elbow [Automatically generated definition].") -AnnotationAssertion( "UBERON:0003399") AnnotationAssertion( "EMAPA:18051") AnnotationAssertion( "FMA:38250") AnnotationAssertion( "MA:0000610") @@ -152192,8 +150458,6 @@ SubClassOf( ObjectSomeValuesFrom( AnnotationAssertion(Annotation( "ISBN:0-683-40008-8") Annotation( "MGI:csmith") Annotation( "MP:0001081") Annotation( "PMID:9362461") "The groups of nerve cell bodies associated with the twelve cranial nerves.") AnnotationAssertion( ) -AnnotationAssertion( "UBERON:0003213") -AnnotationAssertion( "UBERON:0026601") AnnotationAssertion( "BIRNLEX:2597") AnnotationAssertion( "BTO:0000106") AnnotationAssertion( "EFO:0000902") @@ -153917,7 +152181,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (nerve fiber layer of retina) AnnotationAssertion(Annotation( "ISBN:0-914294-08-3") Annotation( "MGI:smb") "Layer of the retina formed by expansion of the fibers of the optic nerve.") -AnnotationAssertion( "UBERON:0005888") AnnotationAssertion(Annotation( "ZFA:0001619") "nerve fiber layer") AnnotationAssertion( "DMBA:15652") AnnotationAssertion( "EMAPA:18591") @@ -154366,7 +152629,6 @@ SubClassOf( ObjectSomeValuesFrom( AnnotationAssertion(Annotation( "Wikipedia:Paravertebral_ganglion") Annotation( "ZFIN:curator") "Trunk ganglion which is part of a bilaterally paired set of sympathetic ganglia located anterior and lateral to the spinal cord.") AnnotationAssertion( ) -AnnotationAssertion( "UBERON:0005466") AnnotationAssertion( "EHDAA2:0001403") AnnotationAssertion( "EHDAA:5635") AnnotationAssertion( "FMA:5891") @@ -154910,7 +153172,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (upper lip) AnnotationAssertion(Annotation( "TAO:0001970") Annotation( "Wikipedia:Upper_lip") "Lip that covers the upper portion of the mouth.[TAO].") -AnnotationAssertion( "UBERON:0003391") AnnotationAssertion( "EMAPA:17925") AnnotationAssertion( "FMA:59817") AnnotationAssertion( "MA:0000919") @@ -154936,7 +153197,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (lower lip) AnnotationAssertion(Annotation( "TAO:0002060") Annotation( "Wikipedia:Lower_lip") "Lip that covers the lower portion of the mouth.[TAO].") -AnnotationAssertion( "UBERON:0003392") AnnotationAssertion( "EMAPA:17909") AnnotationAssertion( "FMA:59818") AnnotationAssertion( "MA:0000921") @@ -155223,7 +153483,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (membranous labyrinth) AnnotationAssertion(Annotation( "FMA:61022") Annotation( "Wikipedia:Membranous_labyrinth") "Organ with organ cavity which consists of the vestibular labyrinth and the cochlear labyrinth. The membranous labyrinth is lodged within the bony labyrinth and has the same general form; it is, however, considerably smaller and is partly separated from the bony walls by a quantity of fluid, the perilymph.[FMA, WP].") -AnnotationAssertion( "UBERON:0010113") AnnotationAssertion( "AAO:0011060") AnnotationAssertion( "EHDAA2:0000899") AnnotationAssertion( "EHDAA:4698") @@ -155669,7 +153928,6 @@ SubClassOf( ObjectSomeValuesFrom( AnnotationAssertion(Annotation( "BIRNLEX:1373") "Subcortical nucleus of telecephalic origin consisting of an elongated gray mass lying lateral to and bordering the lateral ventricle. It is divided into a head, body and tail in some species.") AnnotationAssertion( ) -AnnotationAssertion( "UBERON:0010122") AnnotationAssertion( "BAMS:CA") AnnotationAssertion( "BAMS:Cd") AnnotationAssertion( "BIRNLEX:1373") @@ -156595,7 +154853,6 @@ SubClassOf( ObjectSomeValuesFrom( AnnotationAssertion(Annotation( "ISBN:0-397-51047-0") Annotation( "MGI:cwg") Annotation( "MP:0002285") "The epithelial lining of the trachea which contains numerous ciliated cells.") AnnotationAssertion( ) -AnnotationAssertion( "UBERON:0003227") AnnotationAssertion( "BTO:0001389") AnnotationAssertion( "CALOHA:TS-1061") AnnotationAssertion( "EHDAA2:0002069") @@ -157292,7 +155549,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (epithelium of nasopharynx) AnnotationAssertion(Annotation( "OBOL:automatic") "An epithelium that is part of a nasopharynx [Automatically generated definition].") -AnnotationAssertion( "UBERON:0003237") AnnotationAssertion( "BTO:0004480") AnnotationAssertion( "CALOHA:TS-0662") AnnotationAssertion( "EHDAA2:0001241") @@ -157327,8 +155583,6 @@ SubClassOf(Annotation( "EHD # Class: (Ammon's horn) AnnotationAssertion(Annotation( "BIRNLEX:721") "A part of the brain consisting of a three layered cortex located in the forebrain bordering the medial surface of the lateral ventricle. The term hippocampus is often used synonymously with hippocampal formation which consists of the hippocampus proper or Cornu Ammonis, the dentate gyrus and the subiculum.") -AnnotationAssertion( "UBERON:0003940") -AnnotationAssertion( "UBERON:0004165") AnnotationAssertion( "BAMS:CA") AnnotationAssertion( "BIRNLEX:721") AnnotationAssertion( "BM:Tel-CAM") @@ -158383,7 +156637,6 @@ SubClassOf(Annotation( "VSA # Class: (olfactory epithelium) AnnotationAssertion(Annotation( "Wikipedia:Olfactory_epithelium") "A sensory epithelium inside the nasal cavity that is responsible for detecting odors[WP].") -AnnotationAssertion( "UBERON:0004853") AnnotationAssertion( "AAO:0010158") AnnotationAssertion( "BIRNLEX:2703") AnnotationAssertion( "BTO:0000108") @@ -160777,7 +159030,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (visual system) AnnotationAssertion(Annotation( "NIFSTD:FMAID_7191") "The sensory system subserving the sense of vision.") -AnnotationAssertion( "UBERON:0007036") AnnotationAssertion( "AAO:0000632") AnnotationAssertion( "BILA:0000140") AnnotationAssertion( "EMAPA:36003") @@ -161313,7 +159565,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pronephros) AnnotationAssertion(Annotation( "GO:0048793") Annotation( "Wikipedia:Pronephros") "In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensible for larval life[GO].") -AnnotationAssertion( "UBERON:0005794") AnnotationAssertion( "AAO:0011089") AnnotationAssertion( "BTO:0001541") AnnotationAssertion( "EFO:0000927") @@ -161660,7 +159911,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (endocardium) AnnotationAssertion(Annotation( "GO:0003157") "The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers[GO].") -AnnotationAssertion( "UBERON:0006225") AnnotationAssertion( "AAO:0010408") AnnotationAssertion( "BTO:0000387") AnnotationAssertion( "CALOHA:TS-2075") @@ -161785,7 +160035,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (alveolar sac) AnnotationAssertion(Annotation( "MP:0010902") Annotation( "Wikipedia:Alveolar_sac") "The small terminal dilation of the alveolar ducts around which the alveoli form pocket-like clusters.") -AnnotationAssertion( "UBERON:0008871") AnnotationAssertion( "BTO:0000061") AnnotationAssertion( "EMAPA:35119") AnnotationAssertion( "FMA:7317") @@ -162065,7 +160314,6 @@ SubClassOf( ObjectSomeValuesFrom( AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A portion of adipose tissue that is part of the hypodermis, beneath the dermis.") AnnotationAssertion( ) -AnnotationAssertion( "UBERON:0008875") AnnotationAssertion(Annotation( "MP:0011156") "panniculus adiposus") AnnotationAssertion( "BTO:0004042") AnnotationAssertion( "EMAPA:35829") @@ -163734,7 +161982,6 @@ SubClassOf( ObjectSomeValuesFrom( AnnotationAssertion(Annotation( "PMID:23409159") Annotation( "ZFIN:curator") "Spinal cord structure that is part of the ventricular system and is filled with cerebral-spinal fluid and runs the length of the spinal cord.") AnnotationAssertion( ) -AnnotationAssertion( "UBERON:0002220") AnnotationAssertion( "BAMS:C") AnnotationAssertion( "BAMS:CC") AnnotationAssertion( "BIRNLEX:1409") @@ -164143,7 +162390,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (hippocampus pyramidal layer) AnnotationAssertion(Annotation( "BIRNLEX:1444") "A cytoarchitectural term denoting the layer of the hippocampus in which pyramidal cells are predominant. Its location is superficial to the Stratum oriens; it is deep to the Stratum radiatum in area CA1 and area CA2 and deep to the Stratum lucidum in area CA3 (Stephan-75) (NeuroNames).") -AnnotationAssertion( "UBERON:0005369") AnnotationAssertion( "BAMS:Py") AnnotationAssertion( "BIRNLEX:1444") AnnotationAssertion( "BTO:0001066") @@ -164393,7 +162639,6 @@ SubClassOf( (coelemic cavity lumen) AnnotationAssertion(Annotation( "BTO:0001707") "The cavity within the body of all animals higher than the coelenterates and certain primitive worms, formed by the splitting of the embryonic mesoderm into two layers. In mammals it forms the peritoneal, pleural, and pericardial cavities.") -AnnotationAssertion( "UBERON:0000169") AnnotationAssertion(Annotation( "BTO:0001707") "body cavity") AnnotationAssertion( "AEO:0000186") AnnotationAssertion( "BTO:0001707") @@ -165246,7 +163491,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cardiac Purkinje fiber) AnnotationAssertion(Annotation( "GO:0003165") "The cardiac Purkinje fiber is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle.") -AnnotationAssertion( "UBERON:0004147") AnnotationAssertion( "BTO:0001735") AnnotationAssertion( "EMAPA:35718") AnnotationAssertion( "FMA:9492") @@ -165876,7 +164120,6 @@ SubClassOf( ObjectSomeValuesFrom( AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Any skeletal muscle that is part of the head region.") AnnotationAssertion( ) -AnnotationAssertion( "UBERON:0003899") AnnotationAssertion( "AAO:0000107") AnnotationAssertion( "BTO:0000021") AnnotationAssertion( "EFO:0003524") @@ -166212,7 +164455,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (manual digit) AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A digit that is part of a manus (hand).") -AnnotationAssertion( "UBERON:0000028") AnnotationAssertion( "AAO:0000857") AnnotationAssertion( "BTO:0004669") AnnotationAssertion( "EHDAA2:0000404") @@ -166886,7 +165128,6 @@ SubClassOf( ObjectSomeValuesFrom( AnnotationAssertion(Annotation( "CARO:0002001") Annotation( "http://orcid.org/0000-0002-6601-2165") Annotation( "https://github.com/obophenotype/uberon/issues/29") "Connected anatomical system that forms a barrier between an animal and its environment. In vertebrates, the integumental system consists of the epidermis, dermis plus associated glands and adnexa such as hair and scales. In invertebrates, the integumental system may include cuticle.") AnnotationAssertion( ) -AnnotationAssertion( "UBERON:0007029") AnnotationAssertion( "AEO:0000154") AnnotationAssertion( "BILA:0000118") AnnotationAssertion( "CALOHA:TS-1299") @@ -167626,7 +165867,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (intersomitic artery) AnnotationAssertion(Annotation( "MP:0010662") "The small branching sprouts of the dorsal aorta that grow across the medial surface of the somite, turn right angles to grow over that surface and then fuse with other sprouts and form the vertebral arteries adjacent to the neural tube; the intersomitic arteries supply the body wall and persist in the adult as the posterior intercostal, subcostal and the lumbar arteries.") -AnnotationAssertion( "UBERON:0006001") AnnotationAssertion( "EHDAA2:0000882") AnnotationAssertion( "EHDAA:4340") AnnotationAssertion( "EMAPA:17616") @@ -167693,7 +165933,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (nerve trunk) -AnnotationAssertion( "UBERON:0001147") AnnotationAssertion( "BTO:0000927") AnnotationAssertion( "EHDAA:4675") AnnotationAssertion( "EMAPA:16986") @@ -167717,7 +165956,6 @@ DisjointClasses( (lymphoid system) AnnotationAssertion(Annotation( "Wikipedia:Lymphoid_system") "The lymphatic system in vertebrates is a network of conduits that carry a clear fluid called lymph. It also includes the lymphoid tissue through which the lymph travels. Lymphoid tissue is found in many organs, particularly the lymph nodes, and in the lymphoid follicles associated with the digestive system such as the tonsils. The system also includes all the structures dedicated to the circulation and production of lymphocytes, which includes the spleen, thymus, bone marrow and the lymphoid tissue associated with the digestive system[WP].") -AnnotationAssertion( "UBERON:0002096") AnnotationAssertion( "EHDAA2:0001043") AnnotationAssertion( "EHDAA:8677") AnnotationAssertion(Annotation( "MA:th") "EMAPA:37664") @@ -167775,7 +166013,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (esophagus mucosa) AnnotationAssertion(Annotation( "OBOL:automatic") "A mucosa that is part of a esophagus [Automatically generated definition].") -AnnotationAssertion( "UBERON:0003345") AnnotationAssertion( "BTO:0002859") AnnotationAssertion( "EMAPA:26981") AnnotationAssertion( "FMA:62996") @@ -169195,7 +167432,6 @@ SubClassOf( "ISBN:0-683-40008-8") Annotation( "MP:0002878") "The corticospinal fibers that arise from the pyramidal cells within the cerebral cortex layer V of the precentral motor area, the premotor area and the postcentral gyrus, then descend into and through the medulla to form the lateral corticospinal tract and the anterior corticospinal tract.") AnnotationAssertion( ) -AnnotationAssertion( "UBERON:0004095") AnnotationAssertion(Annotation( "BIRNLEX:1464") Annotation( "MP:0002878") Annotation( "neuronames:1320") Annotation( ) "pyramidal tract") AnnotationAssertion( "BAMS:P") AnnotationAssertion( "BIRNLEX:1464") @@ -170180,7 +168416,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (ear vesicle) AnnotationAssertion(Annotation( "MP:0009806") Annotation( "Wikipedia:Otic_vesicle") "An epithelial sac of invaginated ectoderm formed from the otic placode that gives rise to the structures of the inner ear[MP].") -AnnotationAssertion( "UBERON:0004373") AnnotationAssertion( "AAO:0011080") AnnotationAssertion( "BTO:0002661") AnnotationAssertion( "EHDAA2:0001342") @@ -170397,7 +168632,6 @@ SubClassOf( ObjectSomeValuesFrom( AnnotationAssertion(Annotation( "ISBN:0838580343") Annotation( "MP:0004387") "A horseshoe-shaped thickening of the endoderm at the cranial (rostral) end of the primitive streak formed by the involution of Spemann's organizer cells which, together with the notochord, induces the formation of the neural plate from the overlying ectodermal cells and contributes mesodermal type cells to the surrounding tissue.") AnnotationAssertion( "TODO - check; developmental relationship to anterior hypoblast in ZFA?") -AnnotationAssertion( "UBERON:0004881") AnnotationAssertion(Annotation( "XAO:0000079") "head mesenchyme") AnnotationAssertion(Annotation( "XAO:0000079") "head mesoderm") AnnotationAssertion( "AAO:0011085") @@ -170583,7 +168817,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (eye primordium) AnnotationAssertion(Annotation( "GO:0046619") Annotation( "ZFA:0000570") "Portion of tissue that is part of the anterior neural keel and will form the optic vesicle[ZFA]. A paired ectodermal placode that becomes invaginated to form the embryonic lens vesicles.") -AnnotationAssertion( "UBERON:0005060") AnnotationAssertion( "AAO:0011038") AnnotationAssertion( "EFO:0003541") AnnotationAssertion( "EHDAA2:0004431") @@ -170870,7 +169103,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (lateral plate mesoderm) AnnotationAssertion(Annotation( "MP:0010117") Annotation( "Wikipedia:Lateral_plate_mesoderm") "Portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures[MP].") -AnnotationAssertion( "UBERON:0006258") AnnotationAssertion( "AAO:0010574") AnnotationAssertion( "EHDAA2:0000919") AnnotationAssertion( "EHDAA:379") @@ -171417,7 +169649,6 @@ SubClassOf( (pharyngeal arch 6) AnnotationAssertion(Annotation( "MP:0006347") "The 6th pharyngeal arch. contributes to the development of the sternocleidomastoid and trapezius muscles.") -AnnotationAssertion( "UBERON:0004349") AnnotationAssertion( "AAO:0010368") AnnotationAssertion( "EHDAA2:0004075") AnnotationAssertion( "EMAPA:32766") @@ -171446,7 +169677,6 @@ SubClassOf( (pharyngeal arch artery 1) AnnotationAssertion(Annotation( "MP:0010355") "The vessels formed within the first pair of branchial arches in embryogenesis.") -AnnotationAssertion( "UBERON:0004371") AnnotationAssertion( "AAO:0010415") AnnotationAssertion( "EHDAA2:0000007") AnnotationAssertion( "EMAPA:16202") @@ -171479,7 +169709,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pharyngeal arch artery 2) AnnotationAssertion(Annotation( "MP:0010356") "The vessels formed within the second pair of branchial arches in embryogenesis.") -AnnotationAssertion( "UBERON:0004372") AnnotationAssertion( "AAO:0010418") AnnotationAssertion( "EHDAA2:0000051") AnnotationAssertion( "EMAPA:16203") @@ -171512,7 +169741,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pharyngeal arch artery 3) AnnotationAssertion(Annotation( "MP:0006356") "The vessels formed within the third pair of branchial arches in embryogenesis.") -AnnotationAssertion( "UBERON:0004352") AnnotationAssertion( "AAO:0010419") AnnotationAssertion( "EHDAA2:0000070") AnnotationAssertion( "EMAPA:16687") @@ -171544,7 +169772,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pharyngeal arch artery 4) AnnotationAssertion(Annotation( "MP:0006354") "The vessels formed within the fourth pair of branchial arches in embryogenesis.") -AnnotationAssertion( "UBERON:0004350") AnnotationAssertion( "AAO:0010420") AnnotationAssertion( "EHDAA2:0000087") AnnotationAssertion( "EMAPA:17004") @@ -171596,7 +169823,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pharyngeal arch artery 6) AnnotationAssertion(Annotation( "MP:0006355") "The vessels formed within the sixth pair of branchial arches in embryogenesis.") -AnnotationAssertion( "UBERON:0004351") AnnotationAssertion( "AAO:0010422") AnnotationAssertion( "EHDAA2:0000102") AnnotationAssertion( "EMAPA:17005") @@ -172419,7 +170645,6 @@ SubClassOf(Annotation( "PMI AnnotationAssertion( "we make the germ layer relationship develops_from, as currently the germ layers are declared to be purely embryonic. TODO - check. WP:Amnion - In the human embryo the earliest stages of the formation of the amnion have not been observed; in the youngest embryo which has been studied the amnion was already present as a closed sac, and appears in the inner cell-mass as a cavity. This cavity is roofed in by a single stratum of flattened, ectodermal cells, the amniotic ectoderm, and its floor consists of the prismatic ectoderm of the embryonic disk-the continuity between the roof and floor being established at the margin of the embryonic disk. Outside the amniotic ectoderm is a thin layer of mesoderm, which is continuous with that of the somatopleure and is connected by the body-stalk with the mesodermal lining of the chorion.") AnnotationAssertion( ) -AnnotationAssertion( "UBERON:0008359") AnnotationAssertion( "BTO:0000897") AnnotationAssertion( "EHDAA2:0000117") AnnotationAssertion( "EHDAA:138") @@ -172504,7 +170729,6 @@ SubClassOf( (thyroid primordium endoderm) AnnotationAssertion(Annotation( "OBOL:automatic") "An endoderm that is part of a thyroid primordium.") -AnnotationAssertion( "UBERON:0005235") AnnotationAssertion( "EHDAA:956") AnnotationAssertion( "EMAPA:25357") AnnotationAssertion( "RETIRED_EHDAA2:0002035") @@ -172524,7 +170748,6 @@ SubClassOf(Annotation( "ZFA AnnotationAssertion(Annotation( "OBOL:automatic") "A mesenchyme that is part of a amnion.") AnnotationAssertion( "we make the germ layer relationship develops_from, as currently the germ layers are declared to be purely embryonic. TODO - check. WP:Amnion - In the human embryo the earliest stages of the formation of the amnion have not been observed; in the youngest embryo which has been studied the amnion was already present as a closed sac, and appears in the inner cell-mass as a cavity. This cavity is roofed in by a single stratum of flattened, ectodermal cells, the amniotic ectoderm, and its floor consists of the prismatic ectoderm of the embryonic disk-the continuity between the roof and floor being established at the margin of the embryonic disk. Outside the amniotic ectoderm is a thin layer of mesoderm, which is continuous with that of the somatopleure and is connected by the body-stalk with the mesodermal lining of the chorion.") AnnotationAssertion( ) -AnnotationAssertion( "UBERON:0003411") AnnotationAssertion( "EHDAA2:0000118") AnnotationAssertion( "EHDAA:140") AnnotationAssertion( "EMAPA:16111") @@ -172550,7 +170773,6 @@ SubClassOf( ObjectSomeValuesFrom( AnnotationAssertion(Annotation( "OBOL:automatic") "A mesenchyme that is part of a chorion.") AnnotationAssertion( "TODO - check") -AnnotationAssertion( "UBERON:0003423") AnnotationAssertion( "EHDAA2:0003245") AnnotationAssertion( "EHDAA:154") AnnotationAssertion( "EMAPA:16114") @@ -172976,7 +171198,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (mesoderm blood island) AnnotationAssertion(Annotation( "OBOL:automatic") "A blood island that is part of a mesoderm.") -AnnotationAssertion( "UBERON:0003305") AnnotationAssertion( "EHDAA2:0003241") AnnotationAssertion( "EHDAA:170") AnnotationAssertion(Annotation( "EHDAA2:0003241") Annotation( ) "mesoderm blood islands") @@ -173225,7 +171446,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (mesenchyme of yolk sac) AnnotationAssertion(Annotation( "UBERON:cjm") "The portion of the yolk sac that is derived from mesoderm and consists of mesenchyme.") -AnnotationAssertion( "UBERON:0003264") AnnotationAssertion( "EHDAA2:0002216") AnnotationAssertion( "EHDAA:168") AnnotationAssertion( "EHDAA:205") @@ -173432,7 +171652,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (mesenchyme of footplate) AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that is part of a footplate.") -AnnotationAssertion( "UBERON:0005260") AnnotationAssertion( "EHDAA2:0000549") AnnotationAssertion( "EHDAA:5149") AnnotationAssertion( "EHDAA:6172") @@ -173961,7 +172180,6 @@ SubClassOf(Annotation( "EHD # Class: (pelvic appendage bud ectoderm) AnnotationAssertion(Annotation( "OBOL:automatic") "An unilaminar epithelium that surrounds a pelvic appendage bud.") -AnnotationAssertion( "UBERON:0005232") AnnotationAssertion( "EHDAA2:0001034") AnnotationAssertion( "EMAPA:16780") AnnotationAssertion( "VHOG:0001048") @@ -173986,8 +172204,6 @@ SubClassOf(Annotation( "EHD # Class: (pectoral appendage bud ectoderm) AnnotationAssertion(Annotation( "OBOL:automatic") "An unilaminar epithelium that surrounds a pectoral appendage bud.") -AnnotationAssertion( "UBERON:0005231") -AnnotationAssertion( "UBERON:0005663") AnnotationAssertion( "EHDAA2:0002134") AnnotationAssertion( "EMAPA:16407") AnnotationAssertion( "VHOG:0001047") @@ -174181,7 +172397,6 @@ SubClassOf( ObjectSomeValuesFrom( AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of smooth muscle tissue that is part of a trachea [Automatically generated definition].") AnnotationAssertion( ) -AnnotationAssertion( "UBERON:0004244") AnnotationAssertion( "BTO:0001391") AnnotationAssertion( "EMAPA:19192") AnnotationAssertion( "FMA:262010") @@ -174477,7 +172692,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pectoral appendage bud mesenchyme) AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that is part of a pectoral appendage bud.") -AnnotationAssertion( "UBERON:0005703") AnnotationAssertion( "EHDAA2:0002135") AnnotationAssertion( "EHDAA:1703") AnnotationAssertion( "EMAPA:16408") @@ -175821,7 +174035,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (trachea blood vessel) AnnotationAssertion(Annotation( "OBOL:automatic") "A blood vessel that is part of a trachea.") -AnnotationAssertion( "UBERON:0003525") AnnotationAssertion( "EMAPA:35874") AnnotationAssertion( "MA:0001852") AnnotationAssertion(Annotation( "OBOL:automatic") "blood vessel of trachea") @@ -176355,7 +174568,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (vagus X nerve trunk) AnnotationAssertion(Annotation( "OBOL:automatic") "A nerve trunk that is part of a vagus nerve.") -AnnotationAssertion( "UBERON:0006308") AnnotationAssertion( "EHDAA2:0002160") AnnotationAssertion( "EHDAA:4659") AnnotationAssertion( "EMAPA:17272") @@ -178156,7 +176368,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (forelimb muscle) AnnotationAssertion(Annotation( "OBOL:automatic") "Any muscle organ that is part of a forelimb.") -AnnotationAssertion( "UBERON:0005634") AnnotationAssertion( "AAO:0000204") AnnotationAssertion( "BTO:0000479") AnnotationAssertion( "EMAPA:36049") @@ -179406,7 +177617,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (neural tube lumen) AnnotationAssertion(Annotation( "OBOL:automatic") "An anatomical space that surrounded_by a neural tube.") -AnnotationAssertion( "UBERON:0005713") AnnotationAssertion( "AAO:0011073") AnnotationAssertion( "EHDAA2:0001269") AnnotationAssertion( "EHDAA:2889") @@ -180058,7 +178268,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (Mullerian duct) AnnotationAssertion(Annotation( "GO:0061205") Annotation( "Wikipedia:Paramesonephric_duct") Annotation( "http://www.usm.maine.edu/bio/courses/bio205/bio205_26_sex.html") "Paired ducts of the embryo that run down the lateral sides of the urogenital ridge and terminate at the mullerian eminence in the primitive urogenital sinus. In the female, they will develop to form the fallopian tubes, uterus, and the upper portion of the vagina; in the male, they are lost. These ducts are made of tissue of mesodermal origin[WP]. develops either by lengthwise splitting of the archinephric duct (in chondrichthyans and some amphibians) or by a elongated invagination of the coelomic epithelium (other vertebrates) In males, the oviducts regress. The cranial end of the oviduct maintains an opening into the coelom (which primitively may have been the anteriormost coelomic funnels connecting the nephrocoel with the coelom). This opening is the ostium tubae[USM].") -AnnotationAssertion( "UBERON:0005318") AnnotationAssertion( "AAO:0010141") AnnotationAssertion( "EHDAA2:0004048") AnnotationAssertion( "EMAPA:27665") @@ -180526,7 +178735,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (diencephalic white matter) AnnotationAssertion(Annotation( "OBOL:automatic") "White matter that is part of a diencephalon [Automatically generated definition].") -AnnotationAssertion( "UBERON:0023148") AnnotationAssertion( "BIRNLEX:1678") AnnotationAssertion( "FMA:83931") AnnotationAssertion( "TAO:0000338") @@ -180598,7 +178806,6 @@ SubClassOf( (somatosensory system) AnnotationAssertion(Annotation( "NLXANAT:090818") "The sensory system for the sense of touch and pain.") -AnnotationAssertion( "UBERON:0014511") AnnotationAssertion(Annotation( "MA:th") "EMAPA:37954") AnnotationAssertion( "NLXANAT:090818") AnnotationAssertion( "Wikipedia:Somatosensory_system") @@ -181396,7 +179603,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (frontonasal prominence) AnnotationAssertion(Annotation( "MP:0009901") "The unpaired embryonic prominence that is formed by the tissues surrounding the forebrain vesicle and develops into the forehead and bridge of the nose/snout.") -AnnotationAssertion( "UBERON:0006237") AnnotationAssertion( "EHDAA2:0000578") AnnotationAssertion( "EHDAA:4778") AnnotationAssertion( "EMAPA:16681") @@ -181668,7 +179874,6 @@ SubClassOf( ObjectExactCardinalit # Class: (muscle of auditory ossicle) AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A muscle of the tympanic cavity that attaches to an auditory ossicle.") -AnnotationAssertion( "UBERON:0004112") AnnotationAssertion(Annotation( "MA:th") "EMAPA:37776") AnnotationAssertion( "FMA:49026") AnnotationAssertion( "MA:0000256") @@ -182469,7 +180674,6 @@ SubClassOf( ObjectSomeValuesFrom( AnnotationAssertion(Annotation( "GO:0060741") "The prostate gland stroma is made up of the mesenchymal or fibroblast cells of the prostate gland.") AnnotationAssertion( "TODO - check also FMA Stroma of glandular part of prostate") AnnotationAssertion( ) -AnnotationAssertion( "UBERON:0005084") AnnotationAssertion( "EMAPA:35714") AnnotationAssertion( "FMA:45719") AnnotationAssertion( "MA:0002912") @@ -182628,7 +180832,6 @@ SubClassOf( "GO:0072031") Annotation( "http://sourceforge.net/tracker/?func=detail&atid=440764&aid=3298740&group_id=36855") "The S1 portion is the initial portion of the proximal convoluted tubule and is responsible for avid reabsorption of water and solutes[GO].") AnnotationAssertion( ) -AnnotationAssertion( "UBERON:0006432") AnnotationAssertion(Annotation( "GO:0072031") "S1") AnnotationAssertion( "EMAPA:29657") AnnotationAssertion( "MA:0002612") @@ -182649,7 +180852,6 @@ SubClassOf(Annotation( "GO" AnnotationAssertion(Annotation( "GO:0072032") "The S2 portion of the tubule is involved in reabsorption of water and sodium chloride[GO].") AnnotationAssertion( ) -AnnotationAssertion( "UBERON:0006433") AnnotationAssertion(Annotation( "GO:0072032") "S2") AnnotationAssertion( "EMAPA:29659") AnnotationAssertion( "MA:0002613") @@ -182700,8 +180902,6 @@ SubClassOf(Annotation( "GO" AnnotationAssertion(Annotation( "GO:0072056") Annotation( "http://anatomy.uams.edu/anatomyhtml/kidney.html") "Kidney pyramids are the conical arrangements of tubules that constitute the renal medulla in a multi-lobed mammalian kidney; they contain the loops of Henle and the medullary collecting ducts.") AnnotationAssertion( ) -AnnotationAssertion( "UBERON:0002449") -AnnotationAssertion( "UBERON:0005098") AnnotationAssertion(Annotation( "GO:0072056") "pyramid") AnnotationAssertion( "BTO:0003926") AnnotationAssertion( "FMA:258870") @@ -182784,7 +180984,6 @@ SubClassOf( ObjectSomeValuesFrom( AnnotationAssertion(Annotation( "GO:0072059") "The cortical collecting duct is the portion of the collecting duct that resides in the renal cortex.") AnnotationAssertion( ) -AnnotationAssertion( "UBERON:0005267") AnnotationAssertion( "BTO:0002643") AnnotationAssertion( "EMAPA:28130") AnnotationAssertion( "MA:0002600") @@ -182803,7 +181002,6 @@ SubClassOf( ObjectSomeValuesFrom( AnnotationAssertion(Annotation( "GO:0072060") "The outer medullary collecting duct is the portion of the collecting duct that lies in the renal outer medulla.") AnnotationAssertion( ) -AnnotationAssertion( "UBERON:0005186") AnnotationAssertion( "EMAPA:28346") AnnotationAssertion( "MA:0002599") AnnotationAssertion(Annotation( "MA:0002599") "kidney outer medulla collecting duct") @@ -182820,7 +181018,6 @@ SubClassOf( ObjectSomeValuesFrom( AnnotationAssertion(Annotation( "GO:0072061") "The inner medullary collecting duct is the portion of the collecting duct that lies in the renal inner medulla.") AnnotationAssertion( ) -AnnotationAssertion( "UBERON:0005187") AnnotationAssertion( "BTO:0004544") AnnotationAssertion( "EMAPA:28370") AnnotationAssertion( "MA:0002598") @@ -183468,7 +181665,6 @@ SubClassOf( ObjectSomeValuesFrom( AnnotationAssertion(Annotation( "Wikipedia:Vascular_smooth_muscle") "Smooth muscle found within, and composing the majority of the wall of blood vessels.") AnnotationAssertion( ) -AnnotationAssertion( "UBERON:0010508") AnnotationAssertion( "BTO:0001431") AnnotationAssertion( "CALOHA:TS-1107") AnnotationAssertion( "EMAPA:35177") @@ -183856,7 +182052,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (hindlimb stylopod muscle) AnnotationAssertion(Annotation( "OBOL:automatic") "Any muscle organ that is part of a hindlimb stylopod (upper leg)[Automatically generated definition].") -AnnotationAssertion( "UBERON:0000374") AnnotationAssertion( "BTO:0001367") AnnotationAssertion( "EMAPA:19144") AnnotationAssertion( "FMA:22470") @@ -183877,7 +182072,6 @@ SubClassOf(Annotation( "pro AnnotationAssertion(Annotation( "OBOL:automatic") "Any muscle organ that is part of a skin of body [Automatically generated definition].") AnnotationAssertion( "review as part of general integumentary system review - part of skin, or more generally, integumental system") -AnnotationAssertion( "UBERON:0015797") AnnotationAssertion( "EMAPA:18187") AnnotationAssertion( "EMAPA:35776") AnnotationAssertion( "MA:0002710") @@ -184755,7 +182949,6 @@ SubClassOf( "MP:0002672") "One of a series of paired embryological vascular structures formed within a pharyngeal arch; in the adult, some of these vessels give rise to the great vessels[MP].") AnnotationAssertion( "add specific artery derivatives") -AnnotationAssertion( "UBERON:0004342") AnnotationAssertion( "AAO:0010414") AnnotationAssertion( "EFO:0003695") AnnotationAssertion( "EHDAA2:0000186") @@ -185270,7 +183463,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (carpal region) AnnotationAssertion(Annotation( "Wikipedia:Wrist") Annotation( "https://orcid.org/0000-0002-6601-2165") "A mesopodium that is part of a manus. Includes as parts the carpal skeleton and associated tissues[cjm]. The anatomical region surrounding the carpus including the distal parts of the bones of the forearm and the proximal parts of the metacarpus or five metacarpal bones and the series of joints between these bones, thus referred to as wrist joints. This region also includes the carpal tunnel, the anatomical snuff box, the flexor retinaculum, and the extensor retinaculum[WP,unvetted].") -AnnotationAssertion( "UBERON:0001462") AnnotationAssertion( "EHDAA2:0000218") AnnotationAssertion( "EHDAA:5196") AnnotationAssertion( "EMAPA:19122") @@ -185340,7 +183532,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (tarsal region) AnnotationAssertion(Annotation( "Wikipedia:Ankle") Annotation( "https://orcid.org/0000-0002-6601-2165") "Mesopodial segment of the pes, including the tarsal skeleton and associated tissues.") -AnnotationAssertion( "UBERON:0002388") AnnotationAssertion( "CALOHA:TS-2219") AnnotationAssertion( "EFO:0001409") AnnotationAssertion( "EMAPA:32783") @@ -185376,7 +183567,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (neurula embryo) AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "An embryo at the neurula stage.") -AnnotationAssertion( "UBERON:0007013") AnnotationAssertion( "BILA:0000061") AnnotationAssertion( "BTO:0001766") AnnotationAssertion( "NCIT:C34229") @@ -185505,7 +183695,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (musculature of leg) AnnotationAssertion(Annotation( "OBOL:automatic") "Any collection of muscles that is part of a lower leg or upper leg [Automatically generated definition].") -AnnotationAssertion( "UBERON:0005632") AnnotationAssertion( "EHDAA2:0000973") AnnotationAssertion(Annotation( "EHDAA2:0000973") "leg muscle system") AnnotationAssertion( "uberon") @@ -185560,8 +183749,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (musculature of pelvic girdle) AnnotationAssertion(Annotation( "OBOL:automatic") "Any collection of muscles that is part of a pelvic girdle [Automatically generated definition].") -AnnotationAssertion( "UBERON:0004485") -AnnotationAssertion( "UBERON:0005633") AnnotationAssertion( "AAO:0000427") AnnotationAssertion( "EHDAA2:0001429") AnnotationAssertion( "EMAPA:18184") @@ -185712,7 +183899,6 @@ SubClassOf( ObjectSomeValuesFrom( AnnotationAssertion(Annotation( "OBOL:automatic") "Any collection of muscles that is part of a limb [Automatically generated definition].") AnnotationAssertion( "currently defined by location rather than attachment") -AnnotationAssertion( "UBERON:0005635") AnnotationAssertion( "EHDAA2:0000995") AnnotationAssertion( "EMAPA:32700") AnnotationAssertion( "FMA:50188") @@ -186853,7 +185039,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (interventricular septum membranous part) AnnotationAssertion(Annotation( "MP:0008823") "The membranous portion of the wall between the two lower chambers of the heart.") -AnnotationAssertion( "UBERON:0004143") AnnotationAssertion(Annotation( "GO:0003149") "membranous septum") AnnotationAssertion(Annotation( "VT:0000018") "ventricle membranous septum") AnnotationAssertion(Annotation( "MP:0008823") "ventricular membranous septum") @@ -186886,7 +185071,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (interventricular septum muscular part) AnnotationAssertion(Annotation( "Wikipedia:Interventricular_septum#Portions") Annotation( "http://orcid.org/0000-0002-6601-2165") "The muscular portion of the wall between the two lower chambers of the heart.") -AnnotationAssertion( "UBERON:0004144") AnnotationAssertion(Annotation( "GO:0003150") "muscular septum") AnnotationAssertion( "EHDAA2:0000885") AnnotationAssertion( "EHDAA:2607") @@ -187012,7 +185196,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (hypoglossal nerve root) AnnotationAssertion(Annotation( "OBOL:automatic") "A nerve root that extends_fibers_into a hypoglossal nerve.") -AnnotationAssertion( "UBERON:0022760") AnnotationAssertion( "BAMS:12n") AnnotationAssertion( "BAMS:12nf") AnnotationAssertion( "BIRNLEX:1288") @@ -187386,7 +185569,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (paired limb/fin) AnnotationAssertion(Annotation( "UBERON:cjm") Annotation( "https://github.com/geneontology/go-ontology/issues/9029") "An appendage that is part of an appendage girdle complex.") -AnnotationAssertion( "UBERON:0009872") AnnotationAssertion( "VSAO:0000067") AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "girdle-associated appendage") AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "limb or fin") @@ -187413,7 +185595,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pelvic appendage) AnnotationAssertion(Annotation( "VSAO:0000150") "Paired appendage that consists of the posterior appendicular skeleton and associated soft and hard tissues, but excludes the pelvic girdle and its associated soft and hard tissues.") -AnnotationAssertion( "UBERON:0009876") AnnotationAssertion( "posterior appendage") AnnotationAssertion( "VSAO:0000126") AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "hindlimb/pelvic fin") @@ -187436,7 +185617,6 @@ DisjointClasses(Annotation( # Class: (pectoral appendage) AnnotationAssertion(Annotation( "VSAO:0000150-modified") "Paired appendage that consists of the anterior appendicular skeleton and associated soft and hard tissues, but excludes the pectoral girdle and its associated soft and hard tissues.") -AnnotationAssertion( "UBERON:0009875") AnnotationAssertion( "anterior appendage") AnnotationAssertion( "VHOG:0001753") AnnotationAssertion( "VSAO:0000125") @@ -187770,7 +185950,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (gastrula) AnnotationAssertion(Annotation( "Wikipedia:Gastrula") Annotation( "Wikipedia:Trilaminar_blastocyst") "Organism at the gastrula stage.") -AnnotationAssertion( "UBERON:0007012") AnnotationAssertion( "BILA:0000060") AnnotationAssertion( "BTO:0001403") AnnotationAssertion(Annotation( ) "FBbt:00005317") @@ -187845,7 +186024,6 @@ SubClassOf(Annotation( # Class: (pronephric glomerulus) AnnotationAssertion(Annotation( "DOI:10.1371/journal.pone.0099864") Annotation( "GO:0072013") Annotation( "GOC:mtg_kidney_jan10") Annotation( "PMID:10572058") Annotation( "PMID:15647339") Annotation( "PMID:9268568") Annotation( "XAO:0000318") "The glomus forms from the splanchnic intermediate mesoderm and is the vascularized filtration unit, filtering the blood before it enters the tubules. The glomus is external to the nephron and extends over more than one body segment.") -AnnotationAssertion( "UBERON:0004191") AnnotationAssertion( "AAO:0011049") AnnotationAssertion( "SCTID:360548001") AnnotationAssertion( "TAO:0001557") @@ -188660,7 +186838,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (prostate gland secretion) AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A bodily secretion that is produced by the prostate gland.") -AnnotationAssertion( "UBERON:0010142") AnnotationAssertion( "EMAPA:36545") AnnotationAssertion( "FMA:66884") AnnotationAssertion( "MA:0002525") @@ -189825,7 +188002,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (alveolar wall) AnnotationAssertion(Annotation( "LG:0012626") Annotation( "MP:0010903") "A wall that contains the alveoli.") -AnnotationAssertion( "UBERON:0008872") AnnotationAssertion( "BTO:0002543") AnnotationAssertion( "EMAPA:35120") AnnotationAssertion( "FMA:14117") @@ -192299,7 +190475,6 @@ SubClassOf(Annotation( "GO" AnnotationAssertion(Annotation( "GO:0072022") Annotation( "Wikipedia:Descending_limb_of_loop_of_Henle") "The descending thin limb is a part of the loop of Henle situated just after the proximal straight tubule (S3). It extends to the tip of the loop of Henle[GO].") AnnotationAssertion( ) -AnnotationAssertion( "UBERON:0005165") AnnotationAssertion( "EMAPA:35514") AnnotationAssertion( "FMA:17719") AnnotationAssertion( "MA:0002625") @@ -192435,7 +190610,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (metanephric nephron) AnnotationAssertion(Annotation( "GO:0072273") "A metanephric nephron is the functional unit of the metanephros[GO].") -AnnotationAssertion( "UBERON:0005142") AnnotationAssertion( "VHOG:0000719") AnnotationAssertion( "uberon") AnnotationAssertion( "UBERON:0005110") @@ -192606,7 +190780,6 @@ SubClassOf( (metanephric distal tubule) AnnotationAssertion(Annotation( "GO:0072235") "The metanephric distal tubule is a metanephric nephron tubule that begins at the metanephric macula densa and extends to the metanephric connecting tubule[GO].") -AnnotationAssertion( "UBERON:0005150") AnnotationAssertion( "uberon") AnnotationAssertion( "UBERON:0005129") AnnotationAssertion(rdfs:label "metanephric distal tubule") @@ -192638,7 +190811,6 @@ SubClassOf( (metanephric glomerulus vasculature) AnnotationAssertion(Annotation( "GO:0072239") "The metanephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the metanephric glomerulus[GO].") -AnnotationAssertion( "UBERON:0005143") AnnotationAssertion( "uberon") AnnotationAssertion( "UBERON:0005133") AnnotationAssertion(rdfs:label "metanephric glomerulus vasculature") @@ -192682,7 +190854,6 @@ SubClassOf(Annotation( # Class: (metanephric capsule) AnnotationAssertion(Annotation( "GO:0072213") "The metanephric capsule is the tough fibrous layer surrounding the metanephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage[GO].") -AnnotationAssertion( "UBERON:0005112") AnnotationAssertion( "uberon") AnnotationAssertion( "UBERON:0005137") AnnotationAssertion(rdfs:label "metanephric capsule") @@ -192744,8 +190915,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (metanephric nephron tubule) AnnotationAssertion(Annotation( "GO:0072282") "A metanephric nephron tubule is an epithelial tube that is part of the metanephric nephron, the functional part of the metanephros[GO].") -AnnotationAssertion( "UBERON:0005128") -AnnotationAssertion( "UBERON:0005152") AnnotationAssertion( "uberon") AnnotationAssertion( "UBERON:0005146") AnnotationAssertion(rdfs:label "metanephric nephron tubule") @@ -192794,7 +190963,6 @@ SubClassOf( (metanephric proximal tubule) AnnotationAssertion(Annotation( "GO:0072288") "The metanephric proximal tubule is a metanephric nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle in the metanephros. It has a brush border epithelial morphology[GO].") -AnnotationAssertion( "UBERON:0005131") AnnotationAssertion( "uberon") AnnotationAssertion( "UBERON:0005151") AnnotationAssertion(rdfs:label "metanephric proximal tubule") @@ -194646,7 +192814,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (mammary bud) AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A bulb of epithelial cells that forms from the mammary placode that develops into the mammary gland.") -AnnotationAssertion( "UBERON:0004181") AnnotationAssertion( "EMAPA:35536") AnnotationAssertion( "lactiferous gland bud") AnnotationAssertion(Annotation( "GO:0060648") "mammary gland bud") @@ -195676,7 +193843,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cartilaginous otic capsule) AnnotationAssertion(Annotation( "OBOL:automatic") "An otic capsule endochondral element that is composed primarily of cartilage tissue.") -AnnotationAssertion( "UBERON:0010351") AnnotationAssertion( "EHDAA2:0001333") AnnotationAssertion( "EHDAA:4704") AnnotationAssertion( "EMAPA:18803") @@ -197391,7 +195557,6 @@ SubClassOf(Annotation( "Bge # Class: (floor plate spinal cord region) AnnotationAssertion(Annotation( "OBOL:automatic") "A multi-tissue structure that is part of a spinal cord and is part of a floor plate.") -AnnotationAssertion( "UBERON:0005247") AnnotationAssertion( "EMAPA:17578") AnnotationAssertion( "TAO:0000890") AnnotationAssertion( "VHOG:0000787") @@ -197611,7 +195776,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (optic foramen) AnnotationAssertion(Annotation( "ISBN:0-683-40008-8") Annotation( "MP:0010704") Annotation( "Wikipedia:Optic_canal") Annotation( "https://github.com/obophenotype/uberon/issues/1213") "An opening in the skull through which cranial nerve II passes.[MP].") -AnnotationAssertion( "UBERON:0006269") AnnotationAssertion( "AAO:0000342") AnnotationAssertion( "EHDAA2:0001312") AnnotationAssertion( "EHDAA:10646") @@ -198151,7 +196315,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pre-muscle condensation) -AnnotationAssertion( "UBERON:0008714") AnnotationAssertion( "AEO:0000149") AnnotationAssertion( "EHDAA2_RETIRED:0003149") AnnotationAssertion( "pre muscle mass") @@ -198912,7 +197075,6 @@ SubClassOf( ObjectSomeValuesFrom( AnnotationAssertion(Annotation( "MP:0005203") Annotation( "Wikipedia:Trabecular_meshwork") "A pore-like structure surrounding the entire circumference of the anterior chamber of the eye through which aqueous humor circulates[MP].") AnnotationAssertion( "TODO check syns - ligaments") -AnnotationAssertion( "UBERON:0004028") AnnotationAssertion( "BTO:0001605") AnnotationAssertion( "CALOHA:TS-1058") AnnotationAssertion( "EFO:0003077") @@ -199655,7 +197817,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (aortico-pulmonary spiral septum) AnnotationAssertion(Annotation( "MP:0010650") Annotation( "Wikipedia:Aorticopulmonary_septum") "The spiral septum that separates the truncus arteriosus into a ventral pulmonary trunk and the dorsal aorta[MP]. The aorticopulmonary septum is developmentally formed from neural crest, specifically the cardiac neural crest, and actively separates the aorta and pulmonary arteries and fuses with the interventricular septum within the heart during development. The actual mechanism of septation of the outflow tract is poorly understood, but is recognized as a dynamic process with contributions from contractile, hemodynamic, and extracellular matrix interactions.") -AnnotationAssertion( "UBERON:0005999") AnnotationAssertion( "CALOHA:TS-2409") AnnotationAssertion( "EHDAA2:0000136") AnnotationAssertion( "EHDAA:2592") @@ -199784,7 +197945,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (rhombic lip) AnnotationAssertion(Annotation( "MGI:anna") Annotation( "MP:0012525") "The posterior section of the developing metencephalon recognized transiently within the vertebrate embryo; the rhombic lip extends posteriorly from the roof of the fourth ventricle to dorsal neuroepithelial cell and can be divided into eight structural units based on rhombomeres 1-8 (r1-r8), recognized at early stages of hindbrain development; producing granule cells and five brainstem nuclei, the rhombic lip plays an important role in developing a complex cerebellar neural system.") -AnnotationAssertion( "UBERON:0013163") AnnotationAssertion( "DHBA:10664") AnnotationAssertion( "EHDAA2:0000231") AnnotationAssertion( "EMAPA:17074") @@ -200396,7 +198556,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (otic pit) AnnotationAssertion(Annotation( "ISBN:0-683-40008-8") Annotation( "MP:0011172") "The pair of depressions of thickened otic placode epithelium, that further develops into the otic vesicles.") -AnnotationAssertion( "UBERON:0009123") AnnotationAssertion( "EHDAA2:0001336") AnnotationAssertion( "EHDAA:929") AnnotationAssertion( "EMAPA:16536") @@ -200438,7 +198597,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (future cardiac ventricle) AnnotationAssertion(Annotation( "ZFA:0001719") "Multi-tissue structure that is part of the heart tube and will become the cardiac ventricle.") -AnnotationAssertion( "UBERON:0010226") AnnotationAssertion( "embryonic ventricle") AnnotationAssertion( "EHDAA2:0001531") AnnotationAssertion( "EMAPA:16350") @@ -200576,7 +198734,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (spleen primordium) AnnotationAssertion(Annotation( "ISBN:0123747295") Annotation( "MP:0011263") "A dense syncitial-like mesenchymal thickening in the dorsal mesogastrium[ISBN]. the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing spleen[MP].") -AnnotationAssertion( "UBERON:0009750") AnnotationAssertion( "EHDAA2:0001904") AnnotationAssertion( "EHDAA:3003") AnnotationAssertion( "EMAPA:18535") @@ -201312,7 +199469,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (otolymph) AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Transudate located within the osseus labyrinth. Otolymph can be further classified with respect to whether it is within the membranous labyrinth (endolymph) or outside the mebranous labyrinth (perilymph).") -AnnotationAssertion( "UBERON:0007793") AnnotationAssertion( "EMAPA:36547") AnnotationAssertion( "GAID:1183") AnnotationAssertion( "MA:0002527") @@ -201977,7 +200133,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (spiral ligament) AnnotationAssertion(Annotation( "Wikipedia:Spiral_ligament") Annotation( "https://github.com/obophenotype/mouse-anatomy-ontology/issues/71") "A spiral thickening of the fibrous lining of the cochlear wall. Spiral ligament secures the membranous cochlear duct to the bony spiral canal of the cochlea. Its spiral ligament fibrocytes function in conjunction with the stria vascularis to mediate cochlear ion homeostasis.") -AnnotationAssertion( "UBERON:0028186") AnnotationAssertion( "BIRNLEX:2524") AnnotationAssertion( "EMAPA:35798") AnnotationAssertion( "FMA:77834") @@ -202269,8 +200424,6 @@ SubClassOf( ObjectSomeValuesFrom( AnnotationAssertion(Annotation( "VSAO:0000157") Annotation( "https://github.com/obophenotype/uberon/issues/204") Annotation( "https://github.com/obophenotype/uberon/issues/339") "Endochondral bone that is dorsoventrally compressed and provides attachment site for muscles of the pectoral appendage.") AnnotationAssertion( ) -AnnotationAssertion( "UBERON:0001124") -AnnotationAssertion( "UBERON:0010904") AnnotationAssertion( "AAO:0000751") AnnotationAssertion( "BTO:0001218") AnnotationAssertion( "CALOHA:TS-0897") @@ -202494,7 +200647,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (embryonic footplate) AnnotationAssertion(Annotation( "MGI:csmith") Annotation( "MP:0004576") Annotation( "UBERON:cjm") Annotation( "https://github.com/obophenotype/mammalian-phenotype-ontology/issues/2218") "The distal elements of the developing limb of vertebrates that will give rise to the pes (foot).") -AnnotationAssertion( "UBERON:0004343") AnnotationAssertion( "foot plate") AnnotationAssertion( "footplate") AnnotationAssertion( "EHDAA:5143") @@ -203016,7 +201168,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (male genital duct) AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "A duct or series of ducts that transports sperm from the gonad. In mammals this is from the seminiferous tubules through rete testis, vas efferentia, epididymis, vas deferens, ejeculatory duct to the urethra.") -AnnotationAssertion( "UBERON:0010140") AnnotationAssertion( "FMA:55678") AnnotationAssertion( "TAO:0001268") AnnotationAssertion( "ZFA:0001268") @@ -203426,7 +201577,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pharyngeal pouch 1) AnnotationAssertion(Annotation( "ISBN:0124020607") Annotation( "PMID:16313389") Annotation( "VHOG:0000970") "A pharyngeal pouch that is between pharyngeal arches 1 and 2.") -AnnotationAssertion( "UBERON:0005718") AnnotationAssertion( "AAO:0011114") AnnotationAssertion( "EFO:0003631") AnnotationAssertion( "EHDAA2:0000016") @@ -203467,7 +201617,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pharyngeal pouch 2) AnnotationAssertion(Annotation( "ISBN:0124020607") Annotation( "PMID:16313389") "A pharyngeal puch that is between the pharyngeal arches 2 and 3.") -AnnotationAssertion( "UBERON:0005715") AnnotationAssertion( "AAO:0011115") AnnotationAssertion( "EFO:0003633") AnnotationAssertion( "EHDAA2:0000058") @@ -203507,7 +201656,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pharyngeal pouch 3) AnnotationAssertion(Annotation( "ISBN:0124020607") Annotation( "PMID:16313389") Annotation( "Wikipedia:Pharyngeal_pouch_(embryology)#Third_pouch") "A pharyngeal pouch that between pharyngeal arches 3 and 4.") -AnnotationAssertion( "UBERON:0005716") AnnotationAssertion( "AAO:0011116") AnnotationAssertion( "EFO:0003634") AnnotationAssertion( "EHDAA2:0000077") @@ -203919,7 +202067,6 @@ SubClassOf( ObjectSomeValuesFrom( AnnotationAssertion(Annotation( "Wikipedia:Tracheobronchial_tree") "The structure from the trachea, bronchi, and bronchioles that forms the airways that supply air to the lungs. The lining of the tracheobronchial tree consists of ciliated columnar epithelial cells.") AnnotationAssertion( ) -AnnotationAssertion( "UBERON:0004102") AnnotationAssertion( "FMA:7393") AnnotationAssertion( "NCIT:C117875") AnnotationAssertion( "SCTID:361384001") @@ -204939,7 +203086,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (nucleus of midbrain tegmentum) AnnotationAssertion(Annotation( "OBOL:automatic") "A nucleus of brain that spans a midbrain tegmentum.") -AnnotationAssertion( "UBERON:0012277") AnnotationAssertion( "FMA:258768") AnnotationAssertion( "ZFA:0005577") AnnotationAssertion(Annotation( ) "tegmental nuclei") @@ -205393,7 +203539,6 @@ SubClassOf( "http://orcid.org/0000-0002-6601-2165") "A developing mesenchymal capsule that covers the developing brain and spinal cord and is the precursor of the meningeal cluster. In mammals this gives rise to the arachnoid mater, pia mater and dura mater. In cyclostomes and fishes, the future meninx gives rise to a single meningeal layer, the primitive meninx.") AnnotationAssertion( "decide whether to treat the endo and ecto meninx as subtypes or parts of the future meninx") -AnnotationAssertion( "UBERON:0004065") AnnotationAssertion( "EHDAA2:0004453") AnnotationAssertion(Annotation( "EHDAA2:0004453") "primary meninx") AnnotationAssertion( "uberon") @@ -205425,7 +203570,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (ectomeninx) AnnotationAssertion(Annotation( "ISBN:9781607950325") "The outermost layer of the mesenchymal capsule that surrounds the developing brain, of mixed paraxial mesoderm and neural crest origin. The ectomeninx forms the dura mater (both inner layer and outer chondrogenic layer).") -AnnotationAssertion( "UBERON:0010115") AnnotationAssertion( "EHDAA2:0004317") AnnotationAssertion(Annotation( "EHDAA2:0004317") "future dura mater") AnnotationAssertion( "uberon") @@ -205884,7 +204028,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (appendage girdle region) AnnotationAssertion(Annotation( "UBERONREF:0000003") Annotation( "https://orcid.org/0000-0002-6601-2165") "An organism subdivision that encompasses the region containing the pectoral or pelvic girdle. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc).") -AnnotationAssertion( "UBERON:0007824") AnnotationAssertion( "girdle") AnnotationAssertion( "girdle region") AnnotationAssertion(Annotation( "MA:th") "EMAPA:37854") @@ -207356,7 +205499,6 @@ SubClassOf( ObjectSomeValuesFrom( AnnotationAssertion(Annotation( "ISBN:0123813611") Annotation( "MP:0011157") "Any skeletal muscle organ in the hypodermis / superficial fascia.") AnnotationAssertion( "We follow MP and treat this as part of the hypodermis, although some sources may consider the hypodermis to be superficial to this") -AnnotationAssertion( "UBERON:0010934") AnnotationAssertion( "EMAPA:18188") AnnotationAssertion( "MA:0003140") AnnotationAssertion(Annotation( "MP:0011157") "hypodermal muscle layer") @@ -207896,7 +206038,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (vasculature of brain) AnnotationAssertion(Annotation( "BTO:0003840") "System pertaining to blood vessels in the brain.") -AnnotationAssertion( "UBERON:0005284") AnnotationAssertion( "BTO:0003840") AnnotationAssertion( "EFO:0003491") AnnotationAssertion( "EMAPA:35186") @@ -208311,7 +206452,6 @@ SubClassOf(Annotation( "EHD # Class: (pleuroperitoneal membrane) AnnotationAssertion(Annotation( "Wikipedia:Pleuroperitoneal") Annotation( "http://medical-dictionary.thefreedictionary.com/pleuroperitoneal+membrane") "A fold of tissue which extends into the peritoneal cavity of the developing embryo and participates in the separation of the pleural and peritoneal cavities.") -AnnotationAssertion( "UBERON:0009146") AnnotationAssertion( "EHDAA2:0001483") AnnotationAssertion( "EMAPA:17709") AnnotationAssertion( "NCIT:C34256") @@ -208348,7 +206488,6 @@ SubClassOf( ObjectSomeValuesFrom( AnnotationAssertion(Annotation( "https://github.com/obophenotype/human-developmental-anatomy-ontology/issues/7") "Sum total of mesenchyme in the embryo.") AnnotationAssertion( "consider adding new class (EMAPA:16097) for mesenchyme of embryo (some mesenchyme is extraembryonic - e.g. amnion mesoderm)") -AnnotationAssertion( "UBERON:0003313") AnnotationAssertion( "EHDAA2:0001113") AnnotationAssertion( "EHDAA:177") AnnotationAssertion( "EMAPA:16097") @@ -208982,7 +207121,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (distal segment of manual digit) AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "A segment of the manual digit containing the distal phalanx.") -AnnotationAssertion( "UBERON:0004093") AnnotationAssertion( "SCTID:312543003") AnnotationAssertion(Annotation( "DOI:10.1038/nature10346") "finger digit tip") AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "finger distal segment") @@ -209283,7 +207421,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (1st arch mandibular mesenchyme) AnnotationAssertion(Annotation( "OBOL:automatic") "Mesenchyme that is part of a 1st arch mandibular component.") -AnnotationAssertion( "UBERON:0010043") AnnotationAssertion( "EHDAA2:0000034") AnnotationAssertion( "EMAPA:16385") AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "mesenchymal region of mandibular component of first pharyngeal arch") @@ -210415,7 +208552,6 @@ SubClassOf( ObjectSomeValuesFrom( AnnotationAssertion(Annotation( "ISBN:0073040584") Annotation( "Wikipedia:Stomach#Sections") "A division of the stomach. The stomach can be divided based on mucosal histology (glandular epithelium and gastric glands) and the relative position and type of gastric gland.") AnnotationAssertion( "We follow Kardong in defining stomach regions by gland, but we also include 'body of stomach'. In future we may want to have different partitions of the stomach") -AnnotationAssertion( "UBERON:0009034") AnnotationAssertion( "EMAPA:35821") AnnotationAssertion( "FMA:14558") AnnotationAssertion( "MA:0002561") @@ -211414,7 +209550,6 @@ SubClassOf(Annotation( "cjm # Class: (oral gland) AnnotationAssertion(Annotation( "ISBN:0073040584") "Gland of the epithelium lining the oral cavity. The most common are the salivary glands.") -AnnotationAssertion( "UBERON:0003293") AnnotationAssertion( "EHDAA2:0001327") AnnotationAssertion( "EHDAA:2181") AnnotationAssertion( "EMAPA:16572") @@ -213059,7 +211194,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (odontoid tissue) AnnotationAssertion(Annotation( "GO_REF:0000034") Annotation( "PSPUB:0000170") Annotation( "VSAO:0000063") Annotation( "http://dx.plos.org/10.1371/journal.pone.0051070") "Skeletal tissue that is part of the exoskeleton and derived from an odontogenic papilla.") -AnnotationAssertion( "UBERON:0001973") AnnotationAssertion( "EMAPA:35872") AnnotationAssertion( "FMA:63001") AnnotationAssertion( "MA:0002540") @@ -214784,7 +212918,6 @@ SubClassOf(Annotation( "pro AnnotationAssertion(Annotation( "OBOL:automatic") "Am unpaired external naris that lies in the midline of the head.") AnnotationAssertion( ) AnnotationAssertion( ) -AnnotationAssertion( "UBERON:0012123") AnnotationAssertion( "median anterior naris") AnnotationAssertion( "median nostril") AnnotationAssertion(Annotation( "http://tolweb.org/Hyperoartia") "nasohypophysial opening") @@ -214877,7 +213010,6 @@ SubClassOf(Annotation( "VSA # Class: (vertebral element) AnnotationAssertion(Annotation( "GO_REF:0000034") Annotation( "VSAO:0000184") Annotation( "http://dx.plos.org/10.1371/journal.pone.0051070") Annotation( "https://github.com/obophenotype/uberon/issues/294") "Skeletal element that forms around the notochord and is part of the vertebral column.") -AnnotationAssertion( "UBERON:0015005") AnnotationAssertion(Annotation( "https://github.com/obophenotype/uberon/wiki/Modeling-endochondral-elements-Design-Pattern") "vertebra skeletal element") AnnotationAssertion( "VHOG:0001143") AnnotationAssertion( "VSAO:0000184") @@ -215933,8 +214065,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (white matter of telencephalon) AnnotationAssertion(Annotation( "https://orcid.org/0000-0002-6601-2165") "A partion of white matter that is part of a telencephalon. This can be further subdivided in some species, for example, into hemisphere white matter and the corpus callosum.") -AnnotationAssertion( "UBERON:0013202") -AnnotationAssertion( "UBERON:0022550") AnnotationAssertion( "BIRNLEX:1075") AnnotationAssertion( "FMA:83930") AnnotationAssertion( "HBA:9219") @@ -215955,7 +214085,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (gray matter of telencephalon) AnnotationAssertion(Annotation( "OBOL:automatic") "A portion of gray matter that is part of a telencephalon.") -AnnotationAssertion( "UBERON:0024186") AnnotationAssertion( "BIRNLEX:1067") AnnotationAssertion( "FMA:83911") AnnotationAssertion(Annotation( "BIRNLEX:1067") "predominantly gray regional part of telencephalon") @@ -217863,7 +215992,6 @@ SubClassOf( ObjectSomeValuesFrom( AnnotationAssertion(Annotation( "BTO:0001850") Annotation( "Wikipedia:Vaginal_portion_of_cervix") "The part of the cervix uteri that protrudes into the vagina and is lined with stratified squamous epithelium.") AnnotationAssertion( ) -AnnotationAssertion( "UBERON:0010182") AnnotationAssertion( "BTO:0001850") AnnotationAssertion( "CALOHA:TS-1098") AnnotationAssertion( "FMA:77056") @@ -218901,7 +217029,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (cloacal mucosa) AnnotationAssertion(Annotation( "OBOL:automatic") "A mucosa that is part of a cloaca [Automatically generated definition].") -AnnotationAssertion( "UBERON:0003349") AnnotationAssertion( "cloaca mucosa") AnnotationAssertion( "cloaca mucosa of organ") AnnotationAssertion( "cloaca mucous membrane") @@ -219822,7 +217949,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (caudal vertebra cartilage element) AnnotationAssertion(Annotation( "OBOL:automatic") "A caudal vertebra endochondral element that is composed primarily of cartilage tissue.") -AnnotationAssertion( "UBERON:0013517") AnnotationAssertion( "EHDAA2:0000260") AnnotationAssertion( "EMAPA:18044") AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "coccygeal vertebra cartilage element") @@ -219841,7 +217967,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (caudal vertebra pre-cartilage condensation) AnnotationAssertion(Annotation( "OBOL:automatic") "A caudal vertebra endochondral element that is composed primarily of a pre-cartilage condensation.") -AnnotationAssertion( "UBERON:0013518") AnnotationAssertion( "EMAPA:18045") AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "coccygeal vertebra pre-cartilage condensation") AnnotationAssertion(Annotation( "EMAPA:18045") "tail vertebral pre-cartilage condensation") @@ -223714,7 +221839,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (lobe of cerebral hemisphere) AnnotationAssertion(Annotation( "FMA:61823") "Subdivision of telencephalon which is one of a number of subdivisions of each hemisphere separated by both real landmarks (sulci and fissures) and arbitrary boundaries[FMA,modified].") -AnnotationAssertion( "UBERON:0000322") AnnotationAssertion( "BIRNLEX:922") AnnotationAssertion( "BTO:0000445") AnnotationAssertion( "FMA:61823") @@ -223872,7 +221996,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (pharyngeal ectoderm) AnnotationAssertion(Annotation( "PMID:23020903") Annotation( "http://orcid.org/0000-0002-6601-2165") "The external part of the developing pharynx that is made of ectoderm. During vertebrate development, pockets form in pharyngeal ectoderm between the pharyngeal arches.") -AnnotationAssertion( "UBERON:2001379") AnnotationAssertion( "TAO:0001379") AnnotationAssertion( "ZFA:0001379") AnnotationAssertion( "uberon") @@ -224048,7 +222171,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (future central nervous system) AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Primordium that develops into the central nervous system.") -AnnotationAssertion( "UBERON:3000469") AnnotationAssertion( "future CNS") AnnotationAssertion( "presumptive central nervous system") AnnotationAssertion( "uberon") @@ -224063,7 +222185,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (future nervous system) AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Primordium that develops into the nervous system.") -AnnotationAssertion( "UBERON:3000477") AnnotationAssertion( "AAO:0000477") AnnotationAssertion(Annotation( "AAO:0000477") "presumptive nervous system") AnnotationAssertion( "uberon") @@ -224455,7 +222576,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (caudal vertebra endochondral element) AnnotationAssertion(Annotation( "http://orcid.org/0000-0002-6601-2165") "Any vertebra endochondral element that is part of the caudal region of the vertebral column (tail or coccyx).") -AnnotationAssertion( "UBERON:0015006") AnnotationAssertion( "caudal vertebra element") AnnotationAssertion( "tail vertebra element") AnnotationAssertion( "coccygeal vertebra element") @@ -225232,7 +223352,6 @@ SubClassOf( ObjectSomeValuesFrom( # Class: (white matter of pontine tegmentum) -AnnotationAssertion( "UBERON:0025819") AnnotationAssertion( "BIRNLEX:1069") AnnotationAssertion( "FMA:83942") AnnotationAssertion( "HBA:265505486") diff --git a/src/patterns/definitions.owl b/src/patterns/definitions.owl index 7c051e22a..c944bd8c3 100644 --- a/src/patterns/definitions.owl +++ b/src/patterns/definitions.owl @@ -7,8 +7,8 @@ Prefix(rdfs:=) Ontology( - -Annotation(owl:versionInfo "2024-11-07") + +Annotation(owl:versionInfo "2024-11-19") Declaration(Class()) Declaration(Class())