diff --git a/src/ontology/cl-edit.owl b/src/ontology/cl-edit.owl index 970a222fd..c3b72c4cd 100644 --- a/src/ontology/cl-edit.owl +++ b/src/ontology/cl-edit.owl @@ -3044,8 +3044,6 @@ Declaration(Class(obo:CL_4033087)) Declaration(Class(obo:CL_4033088)) Declaration(Class(obo:CL_4033089)) Declaration(Class(obo:CL_4033090)) -Declaration(Class(obo:CL_4033091)) -Declaration(Class(obo:CL_4033093)) Declaration(Class(obo:CL_4040000)) Declaration(Class(obo:CL_4040001)) Declaration(Class(obo:CL_4040002)) @@ -3104,7 +3102,6 @@ Declaration(Class(obo:CL_4047025)) Declaration(Class(obo:CL_4047029)) Declaration(Class(obo:CL_4047030)) Declaration(Class(obo:CL_4047032)) -Declaration(Class(obo:CL_4047034)) Declaration(Class(obo:CL_4047051)) Declaration(Class(obo:CL_4047052)) Declaration(Class(obo:CL_4047101)) @@ -3136,8 +3133,7 @@ Declaration(Class(obo:CL_4052025)) Declaration(Class(obo:CL_4052026)) Declaration(Class(obo:CL_4052027)) Declaration(Class(obo:CL_4052028)) -Declaration(Class(obo:CL_4052029)) -Declaration(Class(obo:CL_4052030)) +Declaration(Class(obo:CL_4052031)) Declaration(Class(obo:CL_4052048)) Declaration(Class(obo:CL_4052049)) Declaration(Class(obo:CP_0000000)) @@ -3159,7 +3155,6 @@ Declaration(Class(obo:GO_0036053)) Declaration(Class(obo:GO_0036376)) Declaration(Class(obo:GO_0042599)) Declaration(Class(obo:GO_0044316)) -Declaration(Class(obo:GO_0045428)) Declaration(Class(obo:GO_0046697)) Declaration(Class(obo:GO_0050893)) Declaration(Class(obo:GO_0070278)) @@ -3241,7 +3236,6 @@ Declaration(Class(obo:UBERON_0000156)) Declaration(Class(obo:UBERON_0000157)) Declaration(Class(obo:UBERON_0000371)) Declaration(Class(obo:UBERON_0000424)) -Declaration(Class(obo:UBERON_0000482)) Declaration(Class(obo:UBERON_0001004)) Declaration(Class(obo:UBERON_0001335)) Declaration(Class(obo:UBERON_0001786)) @@ -4243,7 +4237,7 @@ AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000065 "BTO:0001724") AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000065 "FMA:70550") AnnotationAssertion(Annotation(oboInOwl:hasDbXref "doi:10.53347/rID-51713") oboInOwl:hasNarrowSynonym obo:CL_0000065 "ependymocyte") AnnotationAssertion(rdfs:label obo:CL_0000065 "ependymal cell") -EquivalentClasses(obo:CL_0000065 ObjectIntersectionOf(obo:CL_0000066 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0004670))) +EquivalentClasses(obo:CL_0000065 ObjectIntersectionOf(obo:CL_0000710 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0004670))) SubClassOf(obo:CL_0000065 obo:CL_0000125) SubClassOf(obo:CL_0000065 ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0005929)) SubClassOf(obo:CL_0000065 ObjectSomeValuesFrom(obo:RO_0002207 obo:CL_0000681)) @@ -8594,9 +8588,9 @@ AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0000584 "MESH:D020895") AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:33290721") Annotation(oboInOwl:hasDbXref "https://orcid.org/0000-0001-9610-7627") oboInOwl:hasNarrowSynonym obo:CL_0000584 "differentiated enterocyte") AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:33290721") Annotation(oboInOwl:hasDbXref "https://orcid.org/0000-0001-9610-7627") oboInOwl:hasNarrowSynonym obo:CL_0000584 "mature enterocyte") AnnotationAssertion(rdfs:label obo:CL_0000584 "enterocyte") +SubClassOf(obo:CL_0000584 obo:CL_0000239) SubClassOf(obo:CL_0000584 obo:CL_0000677) SubClassOf(obo:CL_0000584 obo:CL_0002563) -SubClassOf(obo:CL_0000584 ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0005903)) SubClassOf(obo:CL_0000584 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_4047019)) # Class: obo:CL_0000585 (obsolete null cell) @@ -14540,13 +14534,12 @@ SubClassOf(obo:CL_0002074 obo:CL_0002086) # Class: obo:CL_0002075 (brush cell of tracheobronchial tree) -AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "ISBN:0517223651") Annotation(oboInOwl:hasDbXref "PMID:15817800") Annotation(oboInOwl:hasDbXref "PMID:30291131") Annotation(oboInOwl:hasDbXref "PMID:37925434") obo:IAO_0000115 obo:CL_0002075 "A rare type of columnar epithelial cell that is part of the tracheobronchial epithelium. This cell is characterized by a distinctive tuft of apical microvilli, which extends into the cytoplasm, and a pear-shaped morphology, broad at the base and tapering to a narrow apex. It plays vital roles in chemosensation, producing cytokines like IL-25, and enhancing mucociliary clearance through acetylcholine release to support mucus movement and airway defense.") +AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "ISBN:0517223651") Annotation(oboInOwl:hasDbXref "PMID:15817800") obo:IAO_0000115 obo:CL_0002075 "Infrequent type of columnar epithelial cell. This cell is characterized by the presence of a tuft of blunt, squat microvilli (approximately 120-140/cell) on the cell surface. The microvilli contain filaments that stretch into the underlying cytoplasm. They have a distinctive pear shape with a wide base and a narrow microvillous apex. Function not known.") AnnotationAssertion(terms:contributor obo:CL_0002075 ) AnnotationAssertion(oboInOwl:creation_date obo:CL_0002075 "2010-06-29T03:22:46Z"^^xsd:dateTime) AnnotationAssertion(oboInOwl:hasRelatedSynonym obo:CL_0002075 "pulmonary brush cell") AnnotationAssertion(rdfs:label obo:CL_0002075 "brush cell of tracheobronchial tree") EquivalentClasses(obo:CL_0002075 ObjectIntersectionOf(obo:CL_0002204 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0008397))) -SubClassOf(obo:CL_0002075 obo:CL_0000075) # Class: obo:CL_0002076 (endo-epithelial cell) @@ -15308,15 +15301,14 @@ AnnotationAssertion(rdfs:label obo:CL_0002144 "capillary endothelial cell") EquivalentClasses(obo:CL_0002144 ObjectIntersectionOf(obo:CL_0000071 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001915))) SubClassOf(obo:CL_0002144 obo:CL_0002653) -# Class: obo:CL_0002145 (multiciliated columnar cell of tracheobronchial tree) +# Class: obo:CL_0002145 (ciliated columnar cell of tracheobronchial tree) AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "PMID:28400610") obo:IAO_0000115 obo:CL_0002145 "A multi-ciliated epithelial cell located in the trachea and bronchi, characterized by a columnar shape and motile cilia on its apical surface. These cilia facilitate mucociliary clearance by moving mucus and trapped particles toward the pharynx.") AnnotationAssertion(terms:contributor obo:CL_0002145 ) AnnotationAssertion(oboInOwl:creation_date obo:CL_0002145 "2010-08-24T03:38:29Z"^^xsd:dateTime) AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002145 "FMA:70542") -AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002145 "ciliated columnar cell of tracheobronchial tree") AnnotationAssertion(Annotation(oboInOwl:hasDbXref ) Annotation(oboInOwl:hasDbXref "PMID:25386990") rdfs:comment obo:CL_0002145 "These cells possess numerous cilia on their surface, typically ranging from 200 to 300 per cell. The cilia vary in length, measuring between 6 to 7 μm in the upper airways (trachea) and becoming shorter, around 4 μm, in the smaller airways (terminal bronchioles). These cells form a two-layered 'coat' in the airway: the lower 'sol' layer is watery, allowing the cilia to beat in coordinated waves, while the upper 'gel' layer is thick and sticky, trapping inhaled particles.") -AnnotationAssertion(rdfs:label obo:CL_0002145 "multiciliated columnar cell of tracheobronchial tree") +AnnotationAssertion(rdfs:label obo:CL_0002145 "ciliated columnar cell of tracheobronchial tree") EquivalentClasses(obo:CL_0002145 ObjectIntersectionOf(obo:CL_0000075 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0008397) ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0031514) ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0010007))) SubClassOf(obo:CL_0002145 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0002209)) @@ -15652,21 +15644,17 @@ AnnotationAssertion(terms:contributor obo:CL_0002178 ) AnnotationAssertion(oboInOwl:creation_date obo:CL_0002179 "2010-08-25T03:23:22Z"^^xsd:dateTime) -AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002179 "FMA:62949") AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002179 "FMA:86552") -AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002179 "surface mucosal cell of stomach") AnnotationAssertion(rdfs:label obo:CL_0002179 "foveolar cell of stomach") -SubClassOf(obo:CL_0002179 obo:CL_0000075) -SubClassOf(obo:CL_0002179 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001276)) -SubClassOf(obo:CL_0002179 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0070254)) +EquivalentClasses(obo:CL_0002179 ObjectIntersectionOf(obo:CL_0002178 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001276))) # Class: obo:CL_0002180 (mucous cell of stomach) @@ -15688,16 +15676,16 @@ AnnotationAssertion(rdfs:label obo:CL_0002181 "mucous neck cell of gastric gland EquivalentClasses(obo:CL_0002181 ObjectIntersectionOf(obo:CL_0000651 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000325))) SubClassOf(obo:CL_0002181 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001276)) -# Class: obo:CL_0002182 (obsolete surface mucosal cell of stomach) +# Class: obo:CL_0002182 (surface mucosal cell of stomach) -AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "ISBN:0517223651") obo:IAO_0000115 obo:CL_0002182 "OBSOLETE. A simple columnar cell that populates the entire luminal surface including the gastric pits. This cell types secrete mucus to form a thick protective, lubricant layer over the gastric wall.") -AnnotationAssertion(obo:IAO_0100001 obo:CL_0002182 obo:CL_0002179) +AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "ISBN:0517223651") obo:IAO_0000115 obo:CL_0002182 "A simple columnar cell that populates the entire luminal surface including the gastric pits. This cell types secrete mucus to form a thick protective, lubricant layer over the gastric wall.") AnnotationAssertion(terms:contributor obo:CL_0002182 ) AnnotationAssertion(oboInOwl:creation_date obo:CL_0002182 "2010-08-25T03:45:10Z"^^xsd:dateTime) AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002182 "FMA:62949") -AnnotationAssertion(rdfs:comment obo:CL_0002182 "Duplicate with foveolar cell of stomach") -AnnotationAssertion(rdfs:label obo:CL_0002182 "obsolete surface mucosal cell of stomach") -AnnotationAssertion(owl:deprecated obo:CL_0002182 "true"^^xsd:boolean) +AnnotationAssertion(rdfs:label obo:CL_0002182 "surface mucosal cell of stomach") +SubClassOf(obo:CL_0002182 obo:CL_0000075) +SubClassOf(obo:CL_0002182 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001276)) +SubClassOf(obo:CL_0002182 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0070254)) # Class: obo:CL_0002183 (stem cell of gastric gland) @@ -16433,12 +16421,12 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl AnnotationAssertion(terms:contributor obo:CL_0002251 ) AnnotationAssertion(oboInOwl:creation_date obo:CL_0002251 "2010-09-08T09:26:53Z"^^xsd:dateTime) AnnotationAssertion(rdfs:label obo:CL_0002251 "epithelial cell of alimentary canal") -EquivalentClasses(obo:CL_0002251 ObjectIntersectionOf(obo:CL_0000066 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0003929))) +EquivalentClasses(obo:CL_0002251 ObjectIntersectionOf(obo:CL_0000066 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001555))) SubClassOf(obo:CL_0002251 obo:CL_0002076) # Class: obo:CL_0002252 (epithelial cell of esophagus) -AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_0002252 "An epithelial cell of the lining of the esophagus.") +AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_0002252 "An epithelial cell of the esophagus.") AnnotationAssertion(terms:contributor obo:CL_0002252 ) AnnotationAssertion(oboInOwl:creation_date obo:CL_0002252 "2010-09-08T09:28:20Z"^^xsd:dateTime) AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002252 "FMA:63071") @@ -16448,7 +16436,7 @@ SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002252 obo:CL_0002251 # Class: obo:CL_0002253 (epithelial cell of large intestine) -AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_0002253 "An epithelial cell of the lining of the large intestine.") +AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_0002253 "An epithelial cell of the large intestine.") AnnotationAssertion(terms:contributor obo:CL_0002253 ) AnnotationAssertion(oboInOwl:creation_date obo:CL_0002253 "2010-09-08T09:28:22Z"^^xsd:dateTime) AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002253 "BTO:0004297") @@ -16461,7 +16449,7 @@ SubClassOf(obo:CL_0002253 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000127 # Class: obo:CL_0002254 (epithelial cell of small intestine) -AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_0002254 "An epithelial cell of the lining of the small intestine.") +AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_0002254 "An epithelial cell of the small intestine.") AnnotationAssertion(terms:contributor obo:CL_0002254 ) AnnotationAssertion(oboInOwl:creation_date obo:CL_0002254 "2010-09-08T09:41:46Z"^^xsd:dateTime) AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002254 "FMA:256159") @@ -17355,13 +17343,12 @@ AnnotationAssertion(obo:IAO_0000231 obo:CL_0002331 obo:IAO_0000227) AnnotationAssertion(obo:IAO_0100001 obo:CL_0002331 obo:CL_1000349) AnnotationAssertion(owl:deprecated obo:CL_0002331 "true"^^xsd:boolean) -# Class: obo:CL_0002332 (multiciliated epithelial cell of the bronchus) +# Class: obo:CL_0002332 (ciliated cell of the bronchus) AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "PMID:18757316") obo:IAO_0000115 obo:CL_0002332 "A multi-ciliated epithelial cell located in the bronchus epithelium, characterized by a columnar shape and motile cilia on its apical surface.") AnnotationAssertion(terms:contributor obo:CL_0002332 ) AnnotationAssertion(oboInOwl:creation_date obo:CL_0002332 "2010-09-20T02:21:12Z"^^xsd:dateTime) -AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002332 "ciliated epithelial cell of the bronchus") -AnnotationAssertion(rdfs:label obo:CL_0002332 "multiciliated epithelial cell of the bronchus") +AnnotationAssertion(rdfs:label obo:CL_0002332 "ciliated cell of the bronchus") EquivalentClasses(obo:CL_0002332 ObjectIntersectionOf(obo:CL_0000075 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002031) ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0031514) ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0010007))) # Class: obo:CL_0002333 (neural crest derived adipocyte) @@ -17712,15 +17699,14 @@ AnnotationAssertion(rdfs:label obo:CL_0002367 "trabecular meshwork cell") EquivalentClasses(obo:CL_0002367 ObjectIntersectionOf(obo:CL_0000115 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0005969))) SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002367 obo:CL_0000115) -# Class: obo:CL_0002368 (respiratory tract epithelial cell) +# Class: obo:CL_0002368 (respiratory epithelial cell) -AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_0002368 "An epithelial cell of the respiratory tract epithelium. These cells have an endodermal origin.") +AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_0002368 "An endo-epithelial cell of the respiratory tract.") AnnotationAssertion(terms:contributor obo:CL_0002368 ) AnnotationAssertion(oboInOwl:creation_date obo:CL_0002368 "2010-09-23T04:38:49Z"^^xsd:dateTime) AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002368 "BTO:0004533") AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002368 "airway epithelial cell") -AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002368 "respiratory epithelial cell") -AnnotationAssertion(rdfs:label obo:CL_0002368 "respiratory tract epithelial cell") +AnnotationAssertion(rdfs:label obo:CL_0002368 "respiratory epithelial cell") EquivalentClasses(obo:CL_0002368 ObjectIntersectionOf(obo:CL_0000066 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0004802))) SubClassOf(obo:CL_0002368 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0000223)) @@ -17733,14 +17719,13 @@ AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002369 "MESH:D013172") AnnotationAssertion(rdfs:label obo:CL_0002369 "fungal spore") SubClassOf(obo:CL_0002369 obo:CL_0000521) -# Class: obo:CL_0002370 (respiratory tract goblet cell) +# Class: obo:CL_0002370 (respiratory goblet cell) AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl:hasDbXref "ISBN:0721662544") obo:IAO_0000115 obo:CL_0002370 "A simple columnar epithelial cell that secretes mucin. Rough endoplasmic reticulum, mitochondria, the nucleus, and other organelles are concentrated in the basal portion. The apical plasma membrane projects microvilli to increase surface area for secretion.") AnnotationAssertion(terms:contributor obo:CL_0002370 ) AnnotationAssertion(oboInOwl:creation_date obo:CL_0002370 "2010-09-23T04:42:27Z"^^xsd:dateTime) -AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0002370 "respiratory goblet cell") AnnotationAssertion(Annotation(oboInOwl:hasDbXref "MP:0010863") oboInOwl:hasExactSynonym obo:CL_0002370 "respiratory mucosa goblet cells") -AnnotationAssertion(rdfs:label obo:CL_0002370 "respiratory tract goblet cell") +AnnotationAssertion(rdfs:label obo:CL_0002370 "respiratory goblet cell") EquivalentClasses(obo:CL_0002370 ObjectIntersectionOf(obo:CL_0000160 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0004802))) SubClassOf(obo:CL_0002370 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0004802)) @@ -19621,11 +19606,12 @@ SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002562 obo:CL_0000362 # Class: obo:CL_0002563 (intestinal epithelial cell) -AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_0002563 "An epithelial cell of the lining of the intestine.") +AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_0002563 "An epithelial cell of the intestine.") AnnotationAssertion(terms:contributor obo:CL_0002563 ) AnnotationAssertion(oboInOwl:creation_date obo:CL_0002563 "2011-03-01T05:18:31Z"^^xsd:dateTime) AnnotationAssertion(rdfs:label obo:CL_0002563 "intestinal epithelial cell") -EquivalentClasses(obo:CL_0002563 ObjectIntersectionOf(obo:CL_0000066 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001277))) +EquivalentClasses(obo:CL_0002563 ObjectIntersectionOf(obo:CL_0000066 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000160))) +SubClassOf(obo:CL_0002563 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001277)) # Class: obo:CL_0002564 (nucleus pulposus cell of intervertebral disc) @@ -20517,7 +20503,6 @@ AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0002658 "FMA:87194") AnnotationAssertion(rdfs:label obo:CL_0002658 "glandular cell of the large intestine") EquivalentClasses(obo:CL_0002658 ObjectIntersectionOf(obo:CL_0000150 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000059))) SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002658 obo:CL_0000150) -SubClassOf(obo:CL_0002658 obo:CL_0002253) # Class: obo:CL_0002659 (glandular epithelial cell of stomach) @@ -20730,7 +20715,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") Annotation(oboInOwl AnnotationAssertion(terms:contributor obo:CL_0002680 ) AnnotationAssertion(oboInOwl:creation_date obo:CL_0002680 "2011-09-27T11:59:01Z"^^xsd:dateTime) AnnotationAssertion(rdfs:label obo:CL_0002680 "PP cell of intestine") -EquivalentClasses(obo:CL_0002680 ObjectIntersectionOf(obo:CL_0000696 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001277))) +EquivalentClasses(obo:CL_0002680 ObjectIntersectionOf(obo:CL_0000696 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000160))) SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_0002680 obo:CL_0000696) # Class: obo:CL_0002681 (kidney cortical cell) @@ -22121,16 +22106,15 @@ AnnotationAssertion(rdfs:label obo:CL_0005011 "renal alpha-intercalated cell") SubClassOf(obo:CL_0005011 obo:CL_0005010) SubClassOf(obo:CL_0005011 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0046717)) -# Class: obo:CL_0005012 (multiciliated epithelial cell) +# Class: obo:CL_0005012 (multi-ciliated epithelial cell) AnnotationAssertion(Annotation(oboInOwl:hasDbXref "CL:CVS") Annotation(oboInOwl:hasDbXref "PMID:28400610") Annotation(oboInOwl:hasDbXref "PMID:30422572") Annotation(oboInOwl:hasDbXref "PMID:38032388") obo:IAO_0000115 obo:CL_0005012 "A columnar/cuboidal epithelial cell with multiple motile cilia on its apical surface. These cells facilitate the movement of liquids such as mucus or cerebrospinal fluid across the epithelial surface.") AnnotationAssertion(oboInOwl:hasBroadSynonym obo:CL_0005012 "multi-ciliated cell"@en) AnnotationAssertion(oboInOwl:hasBroadSynonym obo:CL_0005012 "multiciliated cell"@en) -AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0005012 "multi-ciliated epithelial cell") AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0005012 "multiciliated epithelial cell"@en) AnnotationAssertion(Annotation(oboInOwl:hasSynonymType obo:OMO_0003000) oboInOwl:hasRelatedSynonym obo:CL_0005012 "MCC"@en) AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:22118931") Annotation(oboInOwl:hasDbXref "PMID:23959957") Annotation(oboInOwl:hasDbXref "PMID:25729351") Annotation(oboInOwl:hasDbXref "PMID:26378583") rdfs:comment obo:CL_0005012 "While the term 'multi-ciliated epithelial cell' refers to cells with multiple motile cilia, there are exceptions where epithelial cells may have multiple non-motile cilia. Examples include olfactory sensory neurons, which have non-motile cilia for sensory detection, and choroid plexus epithelial cells, which possess multiple non-motile cilia with transient motility during development. Multiciliated cells are essential for human health, and their dysfunction can lead to various diseases known as ciliopathies, such as primary ciliary dyskinesia. This condition affects the respiratory system, brain ventricles, and reproductive system, leading to chronic respiratory infections, hydrocephalus, and infertility") -AnnotationAssertion(rdfs:label obo:CL_0005012 "multiciliated epithelial cell") +AnnotationAssertion(rdfs:label obo:CL_0005012 "multi-ciliated epithelial cell") EquivalentClasses(obo:CL_0005012 ObjectIntersectionOf(obo:CL_0000075 ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0031514) ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0010007))) # Class: obo:CL_0005013 (single ciliated epithelial cell) @@ -22786,8 +22770,8 @@ SubClassOf(obo:CL_0008039 ObjectSomeValuesFrom(obo:RO_0002162 obo:NCBITaxon_7742 # Class: obo:CL_0008040 (squamous endothelial cell of venule) AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_0008040 "An endothelial cell of the venule that is squamous shaped. This is in contrast to the cubodial shape of high endothelial venule cells.") +AnnotationAssertion(dc:date obo:CL_0008040 "2024-07-03T19:52:47Z") AnnotationAssertion(terms:contributor obo:CL_0008040 ) -AnnotationAssertion(terms:date obo:CL_0008040 "2024-07-03T19:52:47Z"^^xsd:dateTime) AnnotationAssertion(rdfs:label obo:CL_0008040 "squamous endothelial cell of venule"@en) SubClassOf(obo:CL_0008040 obo:CL_0002139) SubClassOf(obo:CL_0008040 obo:CL_0002653) @@ -23103,7 +23087,8 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "http://orcid.org/0000-0003-41 AnnotationAssertion(terms:contributor obo:CL_0009024 ) AnnotationAssertion(oboInOwl:inSubset obo:CL_0009024 pato:location_grouping) AnnotationAssertion(rdfs:label obo:CL_0009024 "mesothelial cell of small intestine") -EquivalentClasses(obo:CL_0009024 ObjectIntersectionOf(obo:CL_0000077 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001206))) +EquivalentClasses(obo:CL_0009024 ObjectIntersectionOf(obo:CL_0000077 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002108))) +SubClassOf(obo:CL_0009024 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001902)) # Class: obo:CL_0009025 (mesothelial cell of colon) @@ -23112,7 +23097,7 @@ AnnotationAssertion(terms:contributor obo:CL_0009025 ) +AnnotationAssertion(oboInOwl:created_by obo:CL_0017002 ) AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0017002 "neuroendocrine cell of prostate epithelium") AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0017002 "neuroendocrine cell of the prostate") AnnotationAssertion(rdfs:label obo:CL_0017002 "prostate neuroendocrine cell") @@ -24675,14 +24661,14 @@ EquivalentClasses(obo:CL_0017002 ObjectIntersectionOf(obo:CL_0000165 ObjectSomeV # Class: obo:CL_0017003 (epithelial cell of prostatic urethra) AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:30566875") obo:IAO_0000115 obo:CL_0017003 "An epithelial cell that is part of the prostatic urethra.") -AnnotationAssertion(terms:contributor obo:CL_0017003 ) +AnnotationAssertion(oboInOwl:created_by obo:CL_0017003 ) AnnotationAssertion(rdfs:label obo:CL_0017003 "epithelial cell of prostatic urethra") EquivalentClasses(obo:CL_0017003 ObjectIntersectionOf(obo:CL_0000066 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001335))) # Class: obo:CL_0017004 (telocyte) AnnotationAssertion(Annotation(oboInOwl:hasDbXref "MESH:D000067170") Annotation(oboInOwl:hasDbXref "PMID:20367664") Annotation(oboInOwl:hasDbXref "PMID:28714595") Annotation(oboInOwl:hasDbXref "PMID:31311805") Annotation(oboInOwl:hasDbXref "https://en.wikipedia.org/wiki/Telocyte") obo:IAO_0000115 obo:CL_0017004 "A supportive cell with a small, oval-shaped body and one to five telopodes. Telopodes are cytoplasmic protrusions from tens to hundreds of micrometers long and mostly below 0.2 microns of caliber.") -AnnotationAssertion(terms:contributor obo:CL_0017004 ) +AnnotationAssertion(oboInOwl:created_by obo:CL_0017004 ) AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:20367664") oboInOwl:hasNarrowSynonym obo:CL_0017004 "interstitial Cajal cell-like cell") AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:20367664") oboInOwl:hasNarrowSynonym obo:CL_0017004 "interstitial Cajal-like cell") AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:20367664") oboInOwl:hasRelatedSynonym obo:CL_0017004 "ICLC") @@ -24695,8 +24681,8 @@ SubClassOf(obo:CL_0017004 ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0120327)) # Class: obo:CL_0017005 (lymphoblast) AnnotationAssertion(Annotation(oboInOwl:hasDbXref "NCIT:C13013") Annotation(oboInOwl:hasDbXref "http://orcid.org/0000-0001-9990-8331") obo:IAO_0000115 obo:CL_0017005 "A lymphocyte that has gotten larger after being stimulated by an antigen.") -AnnotationAssertion(terms:contributor obo:CL_0017005 ) -AnnotationAssertion(terms:date obo:CL_0017005 "2022-08-17T14:20:01Z"^^xsd:dateTime) +AnnotationAssertion(dc:date obo:CL_0017005 "2022-08-17T14:20:01Z") +AnnotationAssertion(oboInOwl:created_by obo:CL_0017005 ) AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0017005 "BTO:0000772") AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0017005 "EFO:0000572") AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0017005 "FMA:83030") @@ -24707,8 +24693,8 @@ SubClassOf(obo:CL_0017005 ObjectSomeValuesFrom(obo:RO_0002353 obo:GO_0046649)) # Class: obo:CL_0017006 (B-lymphoblast) AnnotationAssertion(Annotation(oboInOwl:hasDbXref "EFO:0005293") Annotation(oboInOwl:hasDbXref "https://orcid.org/0000-0002-2825-0621") obo:IAO_0000115 obo:CL_0017006 "A lymphocyte of B lineage that has gotten larger after being stimulated by an antigen.") -AnnotationAssertion(terms:contributor obo:CL_0017006 ) -AnnotationAssertion(terms:date obo:CL_0017006 "2022-08-17T14:30:32Z"^^xsd:dateTime) +AnnotationAssertion(dc:date obo:CL_0017006 "2022-08-17T14:30:32Z") +AnnotationAssertion(oboInOwl:created_by obo:CL_0017006 ) AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0017006 "EFO:0005293") AnnotationAssertion(oboInOwl:hasDbXref obo:CL_0017006 "FMA:83031") AnnotationAssertion(rdfs:label obo:CL_0017006 "B-lymphoblast") @@ -24718,8 +24704,8 @@ SubClassOf(obo:CL_0017006 obo:CL_0017005) # Class: obo:CL_0017009 (Axl+ dendritic cell, human) AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:28428369") Annotation(oboInOwl:hasDbXref "PMID:29221729") Annotation(oboInOwl:hasDbXref "PMID:31156637") obo:IAO_0000115 obo:CL_0017009 "A human dendritic cell that expresses the AXL and SIGLEC6 genes.") -AnnotationAssertion(terms:contributor obo:CL_0017009 ) -AnnotationAssertion(terms:date obo:CL_0017009 "2022-08-25T14:18:37Z"^^xsd:dateTime) +AnnotationAssertion(dc:date obo:CL_0017009 "2022-08-25T14:18:37Z"^^xsd:dateTime) +AnnotationAssertion(oboInOwl:created_by obo:CL_0017009 ) AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0017009 "AS DC, human") AnnotationAssertion(rdfs:label obo:CL_0017009 "Axl+ dendritic cell, human") SubClassOf(obo:CL_0017009 obo:CL_0001056) @@ -25120,11 +25106,10 @@ EquivalentClasses(obo:CL_1000239 ObjectIntersectionOf(obo:CL_0000125 ObjectSomeV AnnotationAssertion(rdfs:label obo:CL_1000245 "posterior lateral line ganglion neuron") EquivalentClasses(obo:CL_1000245 ObjectIntersectionOf(obo:CL_2000032 ObjectSomeValuesFrom(obo:RO_0002100 obo:UBERON_2001314))) -# Class: obo:CL_1000271 (lung multiciliated epithelial cell) +# Class: obo:CL_1000271 (lung ciliated cell) AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:27864314") obo:IAO_0000115 obo:CL_1000271 "An epithelial cell that is part of the lung epithelium. This cell is characterised by the presence of cilia on its apical surface.") -AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_1000271 "lung ciliated cell") -AnnotationAssertion(rdfs:label obo:CL_1000271 "lung multiciliated epithelial cell") +AnnotationAssertion(rdfs:label obo:CL_1000271 "lung ciliated cell") EquivalentClasses(obo:CL_1000271 ObjectIntersectionOf(obo:CL_0000075 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000115) ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0031514) ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0010007))) # Class: obo:CL_1000272 (lung secretory cell) @@ -25399,7 +25384,7 @@ SubClassOf(obo:CL_1000305 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000236 AnnotationAssertion(Annotation(oboInOwl:hasDbXref "GOC:tfm") obo:IAO_0000115 obo:CL_1000306 "A fibroblast that is part of the tunica adventitia of artery.") AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000306 "FMA:261285") AnnotationAssertion(rdfs:label obo:CL_1000306 "fibroblast of tunica adventitia of artery") -EquivalentClasses(obo:CL_1000306 ObjectIntersectionOf(obo:CL_0000057 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0007240))) +EquivalentClasses(obo:CL_1000306 ObjectIntersectionOf(obo:CL_0000057 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0005734))) SubClassOf(Annotation(oboInOwl:is_inferred "true") obo:CL_1000306 obo:CL_0000057) # Class: obo:CL_1000307 (fibroblast of dense regular elastic tissue) @@ -26187,7 +26172,8 @@ AnnotationAssertion(oboInOwl:hasDbXref obo:CL_1000405 "FMA:63602") AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FMA:63602") oboInOwl:hasExactSynonym obo:CL_1000405 "columnar epitheliocyte of appendix") AnnotationAssertion(Annotation(oboInOwl:hasDbXref "FMA:63602") oboInOwl:hasExactSynonym obo:CL_1000405 "epithelial cell of vermiform appendix") AnnotationAssertion(rdfs:label obo:CL_1000405 "epithelial cell of appendix") -EquivalentClasses(obo:CL_1000405 ObjectIntersectionOf(obo:CL_0000066 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0009697))) +EquivalentClasses(obo:CL_1000405 ObjectIntersectionOf(obo:CL_0000066 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001154))) +SubClassOf(obo:CL_1000405 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0009697)) # Class: obo:CL_1000406 (obo:CL_1000406) @@ -27893,7 +27879,7 @@ SubClassOf(obo:CL_1001509 obo:CL_0000540) AnnotationAssertion(Annotation(oboInOwl:hasDbXref "MP:0010802") obo:IAO_0000115 obo:CL_1001516 "The various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract.") AnnotationAssertion(rdfs:label obo:CL_1001516 "intestinal enteroendocrine cell") -EquivalentClasses(obo:CL_1001516 ObjectIntersectionOf(obo:CL_0000164 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001277))) +EquivalentClasses(obo:CL_1001516 ObjectIntersectionOf(obo:CL_0000164 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001242))) SubClassOf(obo:CL_1001516 ObjectSomeValuesFrom(obo:RO_0002207 obo:CL_4052006)) # Class: obo:CL_1001517 (stomach enteroendocrine cell) @@ -30916,15 +30902,14 @@ SubClassOf(obo:CL_4030006 obo:CL_1001591) SubClassOf(obo:CL_4030006 obo:CL_4052019) SubClassOf(obo:CL_4030006 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0003889)) -# Class: obo:CL_4030007 (fallopian tube multiciliated cell) +# Class: obo:CL_4030007 (fallopian tube ciliated cell) AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:16565155") Annotation(oboInOwl:hasDbXref "https://www.proteinatlas.org/humanproteome/tissue/fallopian+tube") obo:IAO_0000115 obo:CL_4030007 "A multi-ciliated epithelial cell that is part of the fallopian tube, mainly found on the apex of the mucosal folds. This cell exhibits a columnar shape with an oval nucleus and is characterized by the presence of cilia on its surface. The coordinated beating of these cilia, together with peristaltic contractions, contributes to the self-propulsion of spermatozoa, the transport of ovum during ovulation and the transport of the fertilized ovum to the intramural fallopian tube.") AnnotationAssertion(terms:contributor obo:CL_4030007 ) AnnotationAssertion(terms:date obo:CL_4030007 "2022-03-08T12:40:19Z"^^xsd:dateTime) AnnotationAssertion(oboInOwl:hasBroadSynonym obo:CL_4030007 "oviduct ciliated cell") -AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_4030007 "fallopian tube ciliated cell") AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_4030007 "uterine tube ciliated epithelial cell") -AnnotationAssertion(rdfs:label obo:CL_4030007 "fallopian tube multiciliated cell") +AnnotationAssertion(rdfs:label obo:CL_4030007 "fallopian tube ciliated cell") SubClassOf(obo:CL_4030007 obo:CL_0005012) SubClassOf(obo:CL_4030007 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0003889)) SubClassOf(obo:CL_4030007 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0007589)) @@ -31064,13 +31049,12 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:10559635") rdfs:comment AnnotationAssertion(rdfs:label obo:CL_4030022 "renal medullary fibroblast") EquivalentClasses(obo:CL_4030022 ObjectIntersectionOf(obo:CL_0000057 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0005211))) -# Class: obo:CL_4030023 (respiratory tract hillock cell) +# Class: obo:CL_4030023 (respiratory hillock cell) AnnotationAssertion(Annotation(oboInOwl:hasDbXref ) Annotation(oboInOwl:hasDbXref "PMID:30069044") Annotation(oboInOwl:hasDbXref "PMID:32726565") Annotation(oboInOwl:hasDbXref "PMID:33442032") obo:IAO_0000115 obo:CL_4030023 "A hillock cell that is located in respiratory epithelium. In some mammalian species, this cell type has been noted to express KRT13 and KRT4 and is postulated to play a role in squamous barrier function and immunomodulation.") AnnotationAssertion(terms:date obo:CL_4030023 "2022-06-06T08:31:09Z"^^xsd:dateTime) -AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_4030023 "hillock cell of respiratory tract") -AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_4030023 "respiratory hillock cell") -AnnotationAssertion(rdfs:label obo:CL_4030023 "respiratory tract hillock cell") +AnnotationAssertion(oboInOwl:hasNarrowSynonym obo:CL_4030023 "hillock cell of respiratory tract") +AnnotationAssertion(rdfs:label obo:CL_4030023 "respiratory hillock cell") EquivalentClasses(obo:CL_4030023 ObjectIntersectionOf(obo:CL_4030024 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0004802))) # Class: obo:CL_4030024 (hillock cell) @@ -31159,14 +31143,12 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:25311230") rdfs:comment AnnotationAssertion(rdfs:label obo:CL_4030033 "valve endothelial cell") EquivalentClasses(obo:CL_4030033 ObjectIntersectionOf(obo:CL_0000115 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000946))) -# Class: obo:CL_4030034 (respiratory tract multiciliated cell) +# Class: obo:CL_4030034 (respiratory ciliated cell) AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:18757316") Annotation(oboInOwl:hasDbXref "PMID:21364219") Annotation(oboInOwl:hasDbXref "PMID:34044844") Annotation(oboInOwl:hasDbXref "PMID:37834236") obo:IAO_0000115 obo:CL_4030034 "A multiciliated epithelial cell located in the respiratory tract epithelium, characterized by a columnar shape and motile cilia on its apical surface. This cell develops through a highly orchestrated process, transitioning from a basal progenitor via an intermediate deuterosomal cell stage that generates centrioles essential for ciliogenesis.") AnnotationAssertion(terms:date obo:CL_4030034 "2023-01-25T11:06:01Z"^^xsd:dateTime) AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_4030034 "ciliated cell of the respiratory tract") -AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_4030034 "respiratory ciliated cell") -AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_4030034 "respiratory multiciliated cell") -AnnotationAssertion(rdfs:label obo:CL_4030034 "respiratory tract multiciliated cell") +AnnotationAssertion(rdfs:label obo:CL_4030034 "respiratory ciliated cell") EquivalentClasses(obo:CL_4030034 ObjectIntersectionOf(obo:CL_0000075 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0004802) ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0031514) ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0010007))) SubClassOf(obo:CL_4030034 ObjectSomeValuesFrom(obo:RO_0002207 obo:CL_4033044)) @@ -31225,34 +31207,31 @@ AnnotationAssertion(rdfs:label obo:CL_4030039 "von Economo neuron") SubClassOf(obo:CL_4030039 obo:CL_4023009) SubClassOf(obo:CL_4030039 ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0070006)) -# Class: obo:CL_4030040 (endometrial multiciliated epithelial cell) +# Class: obo:CL_4030040 (endometrial ciliated epithelial cell) AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:31290979") Annotation(oboInOwl:hasDbXref "PMID:37999981") Annotation(oboInOwl:hasDbXref "doi:10.1016/j.coemr.2024.100503") Annotation(oboInOwl:hasDbXref "doi:10.1038/s41591-020-1040-z") Annotation(oboInOwl:hasDbXref "https://www.proteinatlas.org/humanproteome/single+cell+type/Glandular+epithelial+cells#endometrialciliatedcells") obo:IAO_0000115 obo:CL_4030040 "A multi-ciliated cell of the endometrial epithelium. This cell is characterized by the presence of 9+2 motile cilia on its apical surface, which facilitates the movement of mucus across the endometrial surface.") AnnotationAssertion(terms:date obo:CL_4030040 "2023-02-09T11:25:14Z"^^xsd:dateTime) AnnotationAssertion(oboInOwl:hasBroadSynonym obo:CL_4030040 "ciliated cell of the uterus") AnnotationAssertion(oboInOwl:hasBroadSynonym obo:CL_4030040 "uterine ciliated cell") AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_4030040 "ciliated cell of the endometrium") -AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_4030040 "endometrial ciliated epithelial cell") AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_4030040 "endometrium ciliated epithelial cell") AnnotationAssertion(Annotation(oboInOwl:hasDbXref "ttps://www.nature.com/articles/s41591-020-1040-z") rdfs:comment obo:CL_4030040 "In human samples, the expression of FOXJ1 protein, a regulator for motile cilia with epithelial lineage identity, has been noted.") -AnnotationAssertion(rdfs:label obo:CL_4030040 "endometrial multiciliated epithelial cell") -EquivalentClasses(obo:CL_4030040 ObjectIntersectionOf(obo:CL_0000075 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0004811) ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0097729) ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0010007))) +AnnotationAssertion(rdfs:label obo:CL_4030040 "endometrial ciliated epithelial cell") +EquivalentClasses(obo:CL_4030040 ObjectIntersectionOf(obo:CL_0005012 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0004811) ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0097729))) -# Class: obo:CL_4030041 (luminal endometrial multiciliated epithelial cell) +# Class: obo:CL_4030041 (luminal endometrial ciliated epithelial cell) AnnotationAssertion(Annotation(oboInOwl:hasDbXref "doi:10.1038/s41591-020-1040-z") obo:IAO_0000115 obo:CL_4030041 "A ciliated cell of the endometrial luminal epithelium. This cell is characterized by the presence of motile cilia on its apical surface.") AnnotationAssertion(terms:date obo:CL_4030041 "2023-02-09T11:34:42Z"^^xsd:dateTime) -AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_4030041 "luminal endometrial ciliated epithelial cell") -AnnotationAssertion(rdfs:label obo:CL_4030041 "luminal endometrial multiciliated epithelial cell") +AnnotationAssertion(rdfs:label obo:CL_4030041 "luminal endometrial ciliated epithelial cell") SubClassOf(obo:CL_4030041 obo:CL_4030040) SubClassOf(obo:CL_4030041 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0011949)) -# Class: obo:CL_4030042 (glandular endometrial multiciliated epithelial cell) +# Class: obo:CL_4030042 (glandular endometrial ciliated epithelial cell) AnnotationAssertion(Annotation(oboInOwl:hasDbXref "doi:10.1038/s41591-020-1040-z") obo:IAO_0000115 obo:CL_4030042 "A ciliated cell of the endometrial glandular epithelium. This cell is characterized by the presence of motile cilia on its apical surface.") AnnotationAssertion(terms:date obo:CL_4030042 "2023-02-09T11:37:30Z"^^xsd:dateTime) -AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_4030042 "glandular endometrial ciliated epithelial cell") -AnnotationAssertion(rdfs:label obo:CL_4030042 "glandular endometrial multiciliated epithelial cell") +AnnotationAssertion(rdfs:label obo:CL_4030042 "glandular endometrial ciliated epithelial cell") SubClassOf(obo:CL_4030042 obo:CL_4030040) SubClassOf(obo:CL_4030042 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0012276)) @@ -32015,17 +31994,16 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:32032773") oboInOwl:hasE AnnotationAssertion(rdfs:label obo:CL_4033047 "OFF midget ganglion cell") EquivalentClasses(obo:CL_4033047 ObjectIntersectionOf(obo:CL_4023033 obo:CL_4023188)) -# Class: obo:CL_4033048 (respiratory tract suprabasal cell) +# Class: obo:CL_4033048 (respiratory suprabasal cell) -AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:25564622") Annotation(oboInOwl:hasDbXref "PMID:34044844") Annotation(oboInOwl:hasDbXref "PMID:35387001") Annotation(oboInOwl:hasDbXref "PMID:37834236") obo:IAO_0000115 obo:CL_4033048 "A respiratory epithelial cell derived from a basal cell, with a topographic nuclear position between the basal and luminal cells of the airway epithelium. This non-basal, intermediate progenitor cell has limited proliferative capacity and can differentiate into multiciliated, secretory, or rare airway cells (ionocytes, tuft cells, neuroendocrine cells). It shares some ultrastructural features with basal cells but lacks the defined characteristics of fully differentiated cellular phenotypes.") +AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:25564622") obo:IAO_0000115 obo:CL_4033048 "A respiratory epithelial cell with topographic nuclear position in between the basal and luminal cell of the airway epithelium. This non-basal, intermediate cell has limited proliferative capacity, ultrastructural features of basal cells and no defined features of the typically differentiated cellular phenotypes.") AnnotationAssertion(terms:contributor obo:CL_4033048 ) AnnotationAssertion(terms:contributor obo:CL_4033048 ) AnnotationAssertion(terms:date obo:CL_4033048 "2023-06-20T10:44:30Z"^^xsd:dateTime) AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:25564622") oboInOwl:hasExactSynonym obo:CL_4033048 "respiratory parabasal cell") -AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_4033048 "respiratory suprabasal cell") AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:25658372") oboInOwl:hasExactSynonym obo:CL_4033048 "respiratory suprabasal progenitor cell") -AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:25658372") Annotation(oboInOwl:hasDbXref "PMID:32726565") Annotation(oboInOwl:hasDbXref "doi:10.1101/2023.04.20.537495") rdfs:comment obo:CL_4033048 "In humans, respiratory tract suprabasal cells have been noted to have enriched expression of the following: CK8, KRT13, IVL, and SERPINB3. Single-cell sequencing indicates that suprabasal cells derived from the nasal epithelium are distinct from those in the tracheobronchial epithelium.") -AnnotationAssertion(rdfs:label obo:CL_4033048 "respiratory tract suprabasal cell") +AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:25658372") Annotation(oboInOwl:hasDbXref "doi:10.1101/2023.04.20.537495") rdfs:comment obo:CL_4033048 "In humans, respiratory suprabasal cells have been noted to have enriched expression of the following: CK8, KRT13, IVL, and SERPINB3.") +AnnotationAssertion(rdfs:label obo:CL_4033048 "respiratory suprabasal cell") SubClassOf(obo:CL_4033048 obo:CL_0000066) SubClassOf(obo:CL_4033048 obo:CL_0011026) SubClassOf(obo:CL_4033048 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0004802)) @@ -32093,14 +32071,13 @@ AnnotationAssertion(terms:date obo:CL_4033054 "2023-08-22T13:40:28Z"^^xsd:dateTi AnnotationAssertion(rdfs:label obo:CL_4033054 "perivascular cell") EquivalentClasses(obo:CL_4033054 ObjectIntersectionOf(obo:CL_0000000 ObjectSomeValuesFrom(obo:RO_0002220 obo:UBERON_0002049))) -# Class: obo:CL_4033055 (airway submucosal gland duct multiciliated cell) +# Class: obo:CL_4033055 (airway submucosal gland duct ciliated cell) AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:17707699") Annotation(oboInOwl:hasDbXref "PMID:30864819") obo:IAO_0000115 obo:CL_4033055 "A multi-ciliated epithelial cell located in ciliated duct of an airway submucosal gland, characterized by a columnar shape and motile cilia on its apical surface.") AnnotationAssertion(terms:contributor obo:CL_4033055 ) AnnotationAssertion(terms:contributor obo:CL_4033055 ) AnnotationAssertion(terms:date obo:CL_4033055 "2023-09-08T10:32:27Z"^^xsd:dateTime) -AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_4033055 "airway submucosal gland duct ciliated cell") -AnnotationAssertion(rdfs:label obo:CL_4033055 "airway submucosal gland duct multiciliated cell") +AnnotationAssertion(rdfs:label obo:CL_4033055 "airway submucosal gland duct ciliated cell") EquivalentClasses(obo:CL_4033055 ObjectIntersectionOf(obo:CL_0000075 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_8410077) ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_8600014) ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0031514) ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0010007))) # Class: obo:CL_4033056 (onychocyte) @@ -32356,31 +32333,6 @@ AnnotationAssertion(rdfs:label obo:CL_4033090 "atretic granulosa cell") SubClassOf(obo:CL_4033090 obo:CL_4033089) SubClassOf(obo:CL_4033090 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0000501)) -# Class: obo:CL_4033091 (glycinergic-GABAergic amacrine cell) - -AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:37124720") obo:IAO_0000115 obo:CL_4033091 "An amacrine cell that uses both GABA and glycine as neurotransmitters.") -AnnotationAssertion(terms:contributor obo:CL_4033091 ) -AnnotationAssertion(terms:date obo:CL_4033091 "2024-12-02T13:44:17Z"^^xsd:dateTime) -AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:37124720") oboInOwl:hasExactSynonym obo:CL_4033091 "glycinergic/GABAergic amacrine neuron") -AnnotationAssertion(rdfs:label obo:CL_4033091 "glycinergic-GABAergic amacrine cell") -EquivalentClasses(obo:CL_4033091 ObjectIntersectionOf(obo:CL_0000561 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0061534) ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0061537))) - -# Class: obo:CL_4033093 (limbal epithelial stem cell of cornea) - -AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:20614614") Annotation(oboInOwl:hasDbXref "PMID:29105366") Annotation(oboInOwl:hasDbXref "PMID:36983561") Annotation(oboInOwl:hasDbXref "PMID:37768272") obo:IAO_0000115 obo:CL_4033093 "A stem cell that is part of the corneo-scleral limbus. This cell type resides at the basal layer of the epithelium and has a small size and high nuclear to cytoplasmatic ratio (Secker and Daniels, 2009). A limbal stem cell is responsible for corneal epithelial renewal and repair (Li et al., 2023), and to help maintain a clear corneal surface by preventing conjunctival epithelial cells from migrating onto the cornea (Wang et al., 2023).") -AnnotationAssertion(terms:contributor obo:CL_4033093 ) -AnnotationAssertion(terms:contributor obo:CL_4033093 ) -AnnotationAssertion(terms:date obo:CL_4033093 "2024-12-11T13:59:19Z"^^xsd:dateTime) -AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:20614614") oboInOwl:hasExactSynonym obo:CL_4033093 "limbal epithelial stem cell") -AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:17562792") oboInOwl:hasExactSynonym obo:CL_4033093 "limbal stem cell") -AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:20614614") Annotation(oboInOwl:hasSynonymType obo:OMO_0003000) oboInOwl:hasRelatedSynonym obo:CL_4033093 "LESC") -AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:36983561") Annotation(oboInOwl:hasSynonymType obo:OMO_0003000) oboInOwl:hasRelatedSynonym obo:CL_4033093 "LSC") -AnnotationAssertion(rdfs:label obo:CL_4033093 "limbal epithelial stem cell of cornea") -EquivalentClasses(obo:CL_4033093 ObjectIntersectionOf(obo:CL_0000034 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0006761))) -SubClassOf(obo:CL_4033093 obo:CL_0000036) -SubClassOf(obo:CL_4033093 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000482)) -SubClassOf(obo:CL_4033093 ObjectSomeValuesFrom(obo:RO_0002203 obo:CL_0000575)) - # Class: obo:CL_4040000 (glial restricted tripotential precursor cell) AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:10719353") obo:IAO_0000115 obo:CL_4040000 "A glial precursor cell that generates oligodendrocytes and type-1 and type-2 astrocytes. It has been shown in some mammals that this cell type may express A2B5, nestin, FGFR-1, FGFR-2, FGFR-3, PLP, and DM-20 antigens. Unlike oligodendrocyte precursor cell, it does not initially express PDGFR-alpha and can differentiate into both type-1 and type-2 astrocytes.") @@ -32400,7 +32352,7 @@ AnnotationAssertion(obo:RO_0002175 obo:CL_4040001 obo:NCBITaxon_9789) AnnotationAssertion(terms:contributor obo:CL_4040001 ) AnnotationAssertion(terms:date obo:CL_4040001 "2023-04-03T15:08:05Z"^^xsd:dateTime) AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:35328607") oboInOwl:hasExactSynonym obo:CL_4040001 "equine chorionic girdle cell") -AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:27280409") rdfs:comment obo:CL_4040001 "Humans, mice and rats have a highly invasive (hemochorial) placentation. Horses have a non-invasive epitheliochorial placenta, except for the transient endometrial cup.") +AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:27280409") oboInOwl:note obo:CL_4040001 "Humans, mice and rats have a highly invasive (hemochorial) placentation. Horses have a non-invasive epitheliochorial placenta, except for the transient endometrial cup.") AnnotationAssertion(rdfs:label obo:CL_4040001 "chorionic girdle cell") SubClassOf(obo:CL_4040001 obo:CL_0000351) SubClassOf(obo:CL_4040001 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0003124)) @@ -32425,7 +32377,7 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:9624168") oboInOwl:hasEx AnnotationAssertion(Annotation(oboInOwl:hasDbXref "https://orcid.org/0000-0002-0819-0473") oboInOwl:hasExactSynonym obo:CL_4040003 "fetal pre-type 2 pneumocyte") AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:12114192") oboInOwl:hasExactSynonym obo:CL_4040003 "fetal pre-type II alveolar epithelial cell") AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_4040003 "fetal pre-type II pneumocyte") -AnnotationAssertion(rdfs:comment obo:CL_4040003 "According to PMID:1316350 this cell type does not yet produce surfactant. According to PMID:9109447 and PMID:12114192 this cell type produces low levels of surfactant that can be increased by administration of very low-density lipoproteins. This cell type is of medical relevance, as a central feature of the fetal respiratory distress syndrome seems to be the presence in the lung of abundant pre-type II alveolar epithelial cells (PMID:1316350).") +AnnotationAssertion(oboInOwl:note obo:CL_4040003 "According to PMID:1316350 this cell type does not yet produce surfactant. According to PMID:9109447 and PMID:12114192 this cell type produces low levels of surfactant that can be increased by administration of very low-density lipoproteins. This cell type is of medical relevance, as a central feature of the fetal respiratory distress syndrome seems to be the presence in the lung of abundant pre-type II alveolar epithelial cells (PMID:1316350).") AnnotationAssertion(rdfs:label obo:CL_4040003 "fetal pre-type II pulmonary alveolar epithelial cell") SubClassOf(obo:CL_4040003 obo:CL_0000322) @@ -32974,7 +32926,7 @@ AnnotationAssertion(terms:contributor obo:CL_4047018 ) -AnnotationAssertion(terms:date obo:CL_4047034 "2024-12-05T11:10:18Z"^^xsd:dateTime) -AnnotationAssertion(rdfs:label obo:CL_4047034 "smooth muscle cell of stomach"@en) -SubClassOf(obo:CL_4047034 obo:CL_0000192) -SubClassOf(obo:CL_4047034 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0008856)) - # Class: obo:CL_4047051 (small intestine BEST4+ enterocyte) AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:24223998") Annotation(oboInOwl:hasDbXref "PMID:34497389") obo:IAO_0000115 obo:CL_4047051 "An enterocyte of the human small intestine expressing bestrophin-4 (BEST4) calcium-activated ion channels. These enterocytes have a disinctive transcriptomic profile and are scattered through the small intestine epithelium.") @@ -33081,7 +33024,10 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:25045600") oboInOwl:hasB AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:28067220") Annotation(oboInOwl:hasDbXref "PMID:37008045") Annotation(oboInOwl:hasSynonymType obo:OMO_0003000) oboInOwl:hasRelatedSynonym obo:CL_4052001 "E1") AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:25045600") Annotation(oboInOwl:hasDbXref "PMID:27311928") rdfs:comment obo:CL_4052001 "multiciliated ependymal cell, with an average of 16 motile cilia per cell, exhibits two types of planar cell polarity (PCP): rotational polarity, with unidirectional cilia orientation, and translational polarity, with asymmetric cilia positioning in the apical area. This location-specific PCP varies across the ventricular wall, aligning with the direction of CSF flow. These cells are interconnected by adherens and gap junctions, which support intercellular communication and maintain the structural integrity of the ependymal layer. Unlike some other cell types, these cells lack tight junctions.") AnnotationAssertion(rdfs:label obo:CL_4052001 "multiciliated ependymal cell") -EquivalentClasses(obo:CL_4052001 ObjectIntersectionOf(obo:CL_0000075 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0004670) ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0031514) ObjectSomeValuesFrom(obo:RO_0000053 obo:PATO_0010007))) +SubClassOf(obo:CL_4052001 obo:CL_0000065) +SubClassOf(obo:CL_4052001 obo:CL_0005012) +SubClassOf(obo:CL_4052001 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0005357)) +SubClassOf(obo:CL_4052001 ObjectSomeValuesFrom(obo:BFO_0000051 obo:GO_0031514)) # Class: obo:CL_4052002 (syncytial cell) @@ -33386,25 +33332,17 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:39198675") Annotation(ob AnnotationAssertion(rdfs:label obo:CL_4052028 "uterine natural killer cell") EquivalentClasses(obo:CL_4052028 ObjectIntersectionOf(obo:CL_0000623 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0000995))) -# Class: obo:CL_4052029 (subpleural fibroblast) - -AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:36543915") Annotation(oboInOwl:hasDbXref "PMID:36769178") Annotation(oboInOwl:hasDbXref "PMID:37291214") obo:IAO_0000115 obo:CL_4052029 "A fibroblast that is located beneath the visceral pleura of the lung. This cell contributes to the development of idiopathic pulmonary fibrosis (IPF) by forming fibrotic lesions that originate subpleurally and extend into lung tissue through activation, proliferation, migration, and differentiation into a myofibroblast.") -AnnotationAssertion(terms:contributor obo:CL_4052029 ) -AnnotationAssertion(terms:date obo:CL_4052029 "2024-11-29T13:54:15Z"^^xsd:dateTime) -AnnotationAssertion(rdfs:label obo:CL_4052029 "subpleural fibroblast") -SubClassOf(obo:CL_4052029 obo:CL_0000057) -SubClassOf(obo:CL_4052029 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002048)) - -# Class: obo:CL_4052030 (adventitial fibroblast) - -AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:28705796") Annotation(oboInOwl:hasDbXref "PMID:36718802") obo:IAO_0000115 obo:CL_4052030 "A fibroblast of the adventitia of a blood vessel. This cell contributes to vascular homeostasis, remodeling, and inflammation by producing extracellular matrix components, cytokines, and growth factors. Adventitial fibroblast can transition into an activated state during injury or disease, marked by increased proliferation, migration, matrix deposition, and contractile protein expression") -AnnotationAssertion(terms:contributor obo:CL_4052030 ) -AnnotationAssertion(terms:date obo:CL_4052030 "2024-12-05T11:01:15Z"^^xsd:dateTime) -AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:36718802") rdfs:comment obo:CL_4052030 "Single-cell transcriptomics of murine aorta identifies two adventitial fibroblast-specific markers, PDGFRA and DPEP1, which were validated at the protein level by immunohistochemistry and flow cytometry across human and murine arteries, highlighting fibroblast heterogeneity in health and cardiovascular disease (CVD) in humans and mice.") -AnnotationAssertion(rdfs:label obo:CL_4052030 "adventitial fibroblast") -EquivalentClasses(obo:CL_4052030 ObjectIntersectionOf(obo:CL_0000057 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0005734))) -SubClassOf(obo:CL_4052030 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0001816)) -SubClassOf(obo:CL_4052030 ObjectSomeValuesFrom(obo:RO_0002215 obo:GO_0070278)) +# Class: obo:CL_4052031 (respiratory airway secretory cell) + +AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:35355013") Annotation(oboInOwl:hasDbXref "PMID:36796082") obo:IAO_0000115 obo:CL_4052031 "A secretory epithelial cell of the respiratory and terminal bronchioles.") +AnnotationAssertion(terms:contributor obo:CL_4052031 ) +AnnotationAssertion(terms:date obo:CL_4052031 "2024-11-29T16:14:31Z"^^xsd:dateTime) +AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:36796082") Annotation(oboInOwl:hasRelatedSynonym obo:OMO_0003000) oboInOwl:hasRelatedSynonym obo:CL_4052031 "RAS cell") +AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:35355018") oboInOwl:hasRelatedSynonym obo:CL_4052031 "terminal and respiratory bronchioles secretory cell") +AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:35355013") Annotation(oboInOwl:hasDbXref "PMID:36796082") rdfs:comment obo:CL_4052031 "The respiratory airway secretory cell is cuboidal and has a unique transcriptomic profile compared to other epithelial cells in the same region. In humans, it functions as a multipotent progenitor, capable of regenerating alveolar type 2 (AT2) cells.") +AnnotationAssertion(rdfs:label obo:CL_4052031 "respiratory airway secretory cell") +SubClassOf(obo:CL_4052031 obo:CL_1100001) +SubClassOf(obo:CL_4052031 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002051)) # Class: obo:CL_4052048 (intercalated cell of salivary gland)