diff --git a/biome.json b/biome.json
index 6bcb2055d9..34cc4503d2 100644
--- a/biome.json
+++ b/biome.json
@@ -41,8 +41,7 @@
         "noAssignInExpressions": "off",
         "noDoubleEquals": "off",
         "noFallthroughSwitchClause": "off",
-        "noRedeclare": "off",
-        "noSelfCompare": "off"
+        "noRedeclare": "off"
       }
     }
   },
diff --git a/runtime/bigarray.js b/runtime/bigarray.js
index c0d35f9c6f..ab767805b0 100644
--- a/runtime/bigarray.js
+++ b/runtime/bigarray.js
@@ -243,8 +243,8 @@ Ml_Bigarray.prototype.compare = function (b, total) {
         if (x > y) return 1;
         if (x != y) {
           if (!total) return Number.NaN;
-          if (x == x) return 1;
-          if (y == y) return -1;
+          if (!Number.isNaN(x)) return 1;
+          if (!Number.isNaN(y)) return -1;
         }
       }
       break;
diff --git a/runtime/compare.js b/runtime/compare.js
index b81b00639c..9805e36db3 100644
--- a/runtime/compare.js
+++ b/runtime/compare.js
@@ -60,8 +60,8 @@ function caml_compare_val_number_custom(num, custom, swap, total) {
   var comp = caml_compare_val_get_custom(custom);
   if (comp) {
     var x = swap > 0 ? comp(custom, num, total) : comp(num, custom, total);
-    if (total && x != x) return swap; // total && nan
-    if (+x != +x) return +x; // nan
+    if (total && Number.isNaN(x)) return swap; // total && nan
+    if (Number.isNan(+x)) return +x; // nan
     if ((x | 0) != 0) return x | 0; // !nan
   }
   return swap;
@@ -159,7 +159,7 @@ function caml_compare_val(a, b, total) {
           }
           if (!comp) caml_invalid_argument("compare: abstract value");
           var x = comp(a, b, total);
-          if (x != x) {
+          if (Number.isNaN(x)) {
             // Protect against invalid UNORDERED
             return total ? -1 : x;
           }
@@ -171,7 +171,7 @@ function caml_compare_val(a, b, total) {
           break;
         case 1256: // compare function
           var x = a.compare(b, total);
-          if (x != x) {
+          if (Number.isNaN(x)) {
             // Protect against invalid UNORDERED
             return total ? -1 : x;
           }
@@ -188,8 +188,8 @@ function caml_compare_val(a, b, total) {
           if (a > b) return 1;
           if (a != b) {
             if (!total) return Number.NaN;
-            if (a == a) return 1;
-            if (b == b) return -1;
+            if (!Number.isNaN(a)) return 1;
+            if (!Number.isNaN(b)) return -1;
           }
           break;
         case 1001: // The rest
@@ -210,8 +210,8 @@ function caml_compare_val(a, b, total) {
           if (a > b) return 1;
           if (a != b) {
             if (!total) return Number.NaN;
-            if (a == a) return 1;
-            if (b == b) return -1;
+            if (!Number.isNaN(a)) return 1;
+            if (!Number.isNaN(b)) return -1;
           }
           break;
         case 1251: // JavaScript Symbol, no ordering.
diff --git a/runtime/ieee_754.js b/runtime/ieee_754.js
index d890101b19..9d16cbefe6 100644
--- a/runtime/ieee_754.js
+++ b/runtime/ieee_754.js
@@ -264,8 +264,8 @@ function caml_float_compare(x, y) {
   if (x === y) return 0;
   if (x < y) return -1;
   if (x > y) return 1;
-  if (x === x) return 1;
-  if (y === y) return -1;
+  if (!Number.isNaN(x)) return 1;
+  if (!Number.isNaN(y)) return -1;
   return 0;
 }
 
@@ -412,22 +412,13 @@ function caml_fma_float(x, y, z) {
       : x;
   }
 
-  if (
-    x === 0 ||
-    x !== x ||
-    x === +1 / 0 ||
-    x === -1 / 0 ||
-    y === 0 ||
-    y !== y ||
-    y === +1 / 0 ||
-    y === -1 / 0
-  ) {
+  if (x === 0 || y === 0 || !Number.isFinite(x) || !Number.isFinite(y)) {
     return x * y + z;
   }
   if (z === 0) {
     return x * y;
   }
-  if (z !== z || z === +1 / 0 || z === -1 / 0) {
+  if (!Number.isFinite(z)) {
     return z;
   }
 
@@ -569,10 +560,11 @@ function caml_float_of_string(s) {
   var res;
   s = caml_jsbytes_of_string(s);
   res = +s;
-  if (s.length > 0 && res === res) return res;
+  //Fast path
+  if (s.length > 0 && !Number.isNaN(res)) return res;
   s = s.replace(/_/g, "");
   res = +s;
-  if ((s.length > 0 && res === res) || /^[+-]?nan$/i.test(s)) return res;
+  if (s.length > 0 && (!Number.isNaN(res) || /^[+-]?nan$/i.test(s))) return res;
   var m = /^ *([+-]?)0x([0-9a-f]+)\.?([0-9a-f]*)(p([+-]?[0-9]+))?/i.exec(s);
   //          1        2             3           5
   if (m) {