diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index 61b76d3a..ea2ee918 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -16,7 +16,7 @@ jobs:
       matrix:
         os: [ubuntu-20.04]
         python-version: ['3.8']
-        toxenv: [docs, quality, django32]
+        toxenv: [docs, quality, django32, django42]
 
     steps:
     - uses: actions/checkout@v1
@@ -37,7 +37,7 @@ jobs:
       run: tox
 
     - name: Run coverage
-      if: matrix.python-version == '3.8' && matrix.toxenv == 'django32'
+      if: matrix.python-version == '3.8' && matrix.toxenv == 'django42'
       uses: codecov/codecov-action@v3
       with:
         flags: unittests
diff --git a/edx_django_utils/cache/tests/test_middleware.py b/edx_django_utils/cache/tests/test_middleware.py
index 9abb4248..57ed08ea 100644
--- a/edx_django_utils/cache/tests/test_middleware.py
+++ b/edx_django_utils/cache/tests/test_middleware.py
@@ -1,7 +1,7 @@
 """
 Tests for the RequestCacheMiddleware.
 """
-from unittest.mock import MagicMock
+from unittest.mock import MagicMock, Mock
 
 from django.test import RequestFactory, TestCase
 
@@ -17,7 +17,8 @@ class TestRequestCacheMiddleware(TestCase):  # pylint: disable=missing-class-doc
 
     def setUp(self):
         super().setUp()
-        self.middleware = middleware.RequestCacheMiddleware()
+        self.mock_response = Mock()
+        self.middleware = middleware.RequestCacheMiddleware(self.mock_response)
         self.request = RequestFactory().get('/')
 
         self.request_cache = RequestCache()
@@ -50,7 +51,8 @@ class TestTieredCacheMiddleware(TestCase):  # pylint: disable=missing-class-docs
 
     def setUp(self):
         super().setUp()
-        self.middleware = middleware.TieredCacheMiddleware()
+        self.mock_response = Mock()
+        self.middleware = middleware.TieredCacheMiddleware(self.mock_response)
         self.request = RequestFactory().get('/')
         self.request.user = self._mock_user(is_staff=True)
 
diff --git a/edx_django_utils/monitoring/tests/test_custom_monitoring.py b/edx_django_utils/monitoring/tests/test_custom_monitoring.py
index 0ca65da6..b0bb1954 100644
--- a/edx_django_utils/monitoring/tests/test_custom_monitoring.py
+++ b/edx_django_utils/monitoring/tests/test_custom_monitoring.py
@@ -3,7 +3,7 @@
 
 Note: See test_middleware.py for the rest of the middleware tests.
 """
-from unittest.mock import call, patch
+from unittest.mock import Mock, call, patch
 
 import ddt
 from django.test import TestCase
@@ -32,6 +32,7 @@ class TestCustomMonitoringMiddleware(TestCase):
     """
     def setUp(self):
         super().setUp()
+        self.mock_response = Mock()
         RequestCache.clear_all_namespaces()
 
     @patch('newrelic.agent')
@@ -62,7 +63,7 @@ def test_accumulate_and_increment(
         ]
 
         # fake a response to trigger attributes reporting
-        middleware_method = getattr(cached_monitoring_middleware_class(), middleware_method_name)
+        middleware_method = getattr(cached_monitoring_middleware_class(self.mock_response), middleware_method_name)
         middleware_method(
             'fake request',
             'fake response',
@@ -101,8 +102,9 @@ def test_accumulate_with_illegal_value(
             call('error_adding_accumulated_metric', 'name=hello, new_value=10, cached_value=None'),
         ]
 
+        self.mock_response = Mock()
         # fake a response to trigger metrics reporting
-        cached_monitoring_middleware_class().process_response(
+        cached_monitoring_middleware_class(self.mock_response).process_response(
             'fake request',
             'fake response',
         )
diff --git a/edx_django_utils/monitoring/tests/test_middleware.py b/edx_django_utils/monitoring/tests/test_middleware.py
index 7e58242c..df57d799 100644
--- a/edx_django_utils/monitoring/tests/test_middleware.py
+++ b/edx_django_utils/monitoring/tests/test_middleware.py
@@ -27,7 +27,8 @@ class TestMonitoringMemoryMiddleware(TestCase):
     @override_switch('edx_django_utils.monitoring.enable_memory_middleware', False)
     @patch('edx_django_utils.monitoring.internal.middleware.log')
     def test_memory_monitoring_when_disabled(self, mock_logger):
-        MonitoringMemoryMiddleware().process_response(
+        mock_response = Mock()
+        MonitoringMemoryMiddleware(mock_response).process_response(
             'fake request',
             'fake response',
         )
@@ -37,7 +38,8 @@ def test_memory_monitoring_when_disabled(self, mock_logger):
     @patch('edx_django_utils.monitoring.internal.middleware.log')
     def test_memory_monitoring_when_enabled(self, mock_logger):
         request = RequestFactory().get('/')
-        MonitoringMemoryMiddleware().process_response(
+        mock_response = Mock()
+        MonitoringMemoryMiddleware(mock_response).process_response(
             request,
             'fake response',
         )
diff --git a/setup.py b/setup.py
index 37dd9383..19c8d394 100644
--- a/setup.py
+++ b/setup.py
@@ -128,6 +128,7 @@ def is_requirement(line):
         'Development Status :: 3 - Alpha',
         'Framework :: Django',
         'Framework :: Django :: 3.2',
+        'Framework :: Django :: 4.2',
         'Intended Audience :: Developers',
         'License :: OSI Approved :: Apache Software License',
         'Natural Language :: English',
diff --git a/tox.ini b/tox.ini
index 398302f4..7925aee8 100644
--- a/tox.ini
+++ b/tox.ini
@@ -1,5 +1,5 @@
 [tox]
-envlist = py38-django{32}
+envlist = py38-django{32, 42}
 
 [doc8]
 ignore = D000, D001
@@ -38,6 +38,7 @@ norecursedirs = .* docs requirements
 [testenv]
 deps = 
     django32: Django>=3.2,<4.0
+    django42: Django>=4.2,<4.3
     -r{toxinidir}/requirements/test.txt
 commands = 
     python -Wd -m pytest {posargs}