The age of remains that contain carbon and are less than about 50,000 years old, such as this pygmy mammoth, can be determined using carbon dating. (credit: Bill Faulkner/NPS)
-To learn more about atoms and isotopes, and how you can tell one isotope from another, visit this site and run the simulation.
+To learn more about atoms and isotopes, and how you can tell one isotope from another, visit this site and run the simulation.Chemical Bonds
diff --git a/modules/m45419/index.cnxml b/modules/m45419/index.cnxml
index a8c5b4813..aee727a56 100644
--- a/modules/m45419/index.cnxml
+++ b/modules/m45419/index.cnxml
@@ -32,7 +32,7 @@
The leaves of this sensitive plant (Mimosa pudica) will instantly droop and fold when touched. After a few minutes, the plant returns to its normal state. (credit: Alex Lomas)
- Watch this video to see how the sensitive plant responds to a touch stimulus.
+ Watch this video to see how the sensitive plant responds to a touch stimulus.Reproduction
@@ -75,7 +75,7 @@ The diversity of life on Earth is a result of mutations, or random changes in he
A molecule, like this large DNA molecule, is composed of atoms. (credit: "Brian0918"/Wikimedia Commons)
- To see an animation of this DNA molecule, click here.Some cells contain aggregates of macromolecules surrounded by membranes; these are called organelles. Organelles are small structures that exist within cells and perform specialized functions. All living things are made of cells; the cell itself is the smallest fundamental unit of structure and function in living organisms. (This requirement is why viruses are not considered living: they are not made of cells. To make new viruses, they have to invade and hijack a living cell; only then can they obtain the materials they need to reproduce.) Some organisms consist of a single cell and others are multicellular. Cells are classified as prokaryotic or eukaryotic. Prokaryotes are single-celled organisms that lack organelles surrounded by a membrane and do not have nuclei surrounded by nuclear membranes; in contrast, the cells of eukaryotes do have membrane-bound organelles and nuclei.
+ To see an animation of this DNA molecule, click here.Some cells contain aggregates of macromolecules surrounded by membranes; these are called organelles. Organelles are small structures that exist within cells and perform specialized functions. All living things are made of cells; the cell itself is the smallest fundamental unit of structure and function in living organisms. (This requirement is why viruses are not considered living: they are not made of cells. To make new viruses, they have to invade and hijack a living cell; only then can they obtain the materials they need to reproduce.) Some organisms consist of a single cell and others are multicellular. Cells are classified as prokaryotic or eukaryotic. Prokaryotes are single-celled organisms that lack organelles surrounded by a membrane and do not have nuclei surrounded by nuclear membranes; in contrast, the cells of eukaryotes do have membrane-bound organelles and nuclei.In most multicellular organisms, cells combine to make tissues, which are groups of similar cells carrying out the same function. Organs are collections of tissues grouped together based on a common function. Organs are present not only in animals but also in plants. An organ system is a higher level of organization that consists of functionally related organs. For example vertebrate animals have many organ systems, such as the circulatory system that transports blood throughout the body and to and from the lungs; it includes organs such as the heart and blood vessels. Organisms are individual living entities. For example, each tree in a forest is an organism. Single-celled prokaryotes and single-celled eukaryotes are also considered organisms and are typically referred to as microorganisms.
diff --git a/modules/m45425/index.cnxml b/modules/m45425/index.cnxml
index 908f573e5..e189e26c8 100644
--- a/modules/m45425/index.cnxml
+++ b/modules/m45425/index.cnxml
@@ -27,7 +27,7 @@
(a) The lattice structure of ice makes it less dense than the freely flowing molecules of liquid water. Ice's lower density enables it to (b) float on water. (credit a: modification of work by Jane Whitney; credit b: modification of work by Carlos Ponte)
-Click here to see a 3-D animation of the structure of an ice lattice.
+Click here to see a 3-D animation of the structure of an ice lattice.Water Is an Excellent SolventBecause water is polar, with slight positive and negative charges, ionic compounds and polar molecules can readily dissolve in it. Water is, therefore, what is referred to as a solvent—a substance capable of dissolving another substance. The charged particles will form hydrogen bonds with a surrounding layer of water molecules. This is referred to as a sphere of hydration and serves to keep the particles separated or dispersed in the water. In the case of table salt (NaCl) mixed in water (), the sodium and chloride ions separate, or dissociate, in the water, and spheres of hydration are formed around the ions. A positively charged sodium ion is surrounded by the partially negative charges of oxygen atoms in water molecules. A negatively charged chloride ion is surrounded by the partially positive charges of hydrogen atoms in water molecules. These spheres of hydration are also referred to as hydration shells. The polarity of the water molecule makes it an effective solvent and is important in its many roles in living systems.
@@ -43,7 +43,7 @@
Cohesive and adhesive forces are important for sustaining life. For example, because of these forces, water can flow up from the roots to the tops of plants to feed the plant.
-To learn more about water, visit the U.S. Geological Survey Water Science for Schools: All About Water! website.
+To learn more about water, visit the U.S. Geological Survey Water Science for Schools: All About Water! website.Buffers, pH, Acids, and BasesThe pH of a solution is a measure of its acidity or bascicity. You have probably used litmuspaper, paper that has been treated with a natural water-soluble dye so it can be used as a pH indicator, to test how much acid or base (basicity) exists in a solution. You might have even used some to make sure the water in an outdoor swimming pool is properly treated. In both cases, this pH test measures the amount of hydrogen ions that exists in a given solution. High concentrations of hydrogen ions yield a low pH, whereas low levels of hydrogen ions result in a high pH. The overall concentration of hydrogen ions is inversely related to its pH and can be measured on the pH scale (). Therefore, the more hydrogen ions present, the lower the pH; conversely, the fewer hydrogen ions, the higher the pH.The pH scale ranges from 0 to 14. A change of one unit on the pH scale represents a change in the concentration of hydrogen ions by a factor of 10, a change in two units represents a change in the concentration of hydrogen ions by a factor of 100. Thus, small changes in pH represent large changes in the concentrations of hydrogen ions. Pure water is neutral. It is neither acidic nor basic, and has a pH of 7.0. Anything below 7.0 (ranging from 0.0 to 6.9) is acidic, and anything above 7.0 (from 7.1 to 14.0) is alkaline. The blood in your veins is slightly alkaline (pH = 7.4). The environment in your stomach is highly acidic (pH = 1 to 2). Orange juice is mildly acidic (pH = approximately 3.5), whereas baking soda is basic (pH = 9.0).
+For an additional perspective on lipids, watch this video about types of fat.ProteinsProteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective; they may serve in transport, storage, or membranes; or they may be toxins or enzymes. Each cell in a living system may contain thousands of different proteins, each with a unique function. Their structures, like their functions, vary greatly. They are all, however, polymers of amino acids, arranged in a linear sequence.
@@ -120,7 +120,7 @@ The chemical nature of the R group determines the chemical nature of the amino a
The four levels of protein structure can be observed in these illustrations. (credit: modification of work by National Human Genome Research Institute)
Each protein has its own unique sequence and shape held together by chemical interactions. If the protein is subject to changes in temperature, pH, or exposure to chemicals, the protein structure may change, losing its shape in what is known as denaturation as discussed earlier. Denaturation is often reversible because the primary structure is preserved if the denaturing agent is removed, allowing the protein to resume its function. Sometimes denaturation is irreversible, leading to a loss of function. One example of protein denaturation can be seen when an egg is fried or boiled. The albumin protein in the liquid egg white is denatured when placed in a hot pan, changing from a clear substance to an opaque white substance. Not all proteins are denatured at high temperatures; for instance, bacteria that survive in hot springs have proteins that are adapted to function at those temperatures.
-For an additional perspective on proteins, explore “Biomolecules: The Proteins” through this interactive animation.
+For an additional perspective on proteins, explore “Biomolecules: The Proteins” through this interactive animation.Nucleic Acids
diff --git a/modules/m45428/index.cnxml b/modules/m45428/index.cnxml
index e07f325b7..4fa09009e 100644
--- a/modules/m45428/index.cnxml
+++ b/modules/m45428/index.cnxml
@@ -27,7 +27,7 @@
Light microscopes commonly used in the undergraduate college laboratory magnify up to approximately 400 times. Two parameters that are important in microscopy are magnification and resolving power. Magnification is the degree of enlargement of an object. Resolving power is the ability of a microscope to allow the eye to distinguish two adjacent structures as separate; the higher the resolution, the closer those two objects can be, and the better the clarity and detail of the image. When oil immersion lenses are used, magnification is usually increased to 1,000 times for the study of smaller cells, like most prokaryotic cells. Because light entering a specimen from below is focused onto the eye of an observer, the specimen can be viewed using light microscopy. For this reason, for light to pass through a specimen, the sample must be thin or translucent.
-For another perspective on cell size, try the HowBig interactive.
+For another perspective on cell size, try the HowBig interactive.A second type of microscope used in laboratories is the dissecting microscope (b). These microscopes have a lower magnification (20 to 80 times the object size) than light microscopes and can provide a three-dimensional view of the specimen. Thick objects can be examined with many components in focus at the same time. These microscopes are designed to give a magnified and clear view of tissue structure as well as the anatomy of the whole organism. Like light microscopes, most modern dissecting microscopes are also binocular, meaning that they have two separate lens systems, one for each eye. The lens systems are separated by a certain distance, and therefore provide a sense of depth in the view of their subject to make manipulations by hand easier. Dissecting microscopes also have optics that correct the image so that it appears as if being seen by the naked eye and not as an inverted image. The light illuminating a sample under a dissecting microscope typically comes from above the sample, but may also be directed from below.Facilitated transport
@@ -54,7 +54,7 @@
A principle of diffusion is that the molecules move around and will spread evenly throughout the medium if they can. However, only the material capable of getting through the membrane will diffuse through it. In this example, the solute cannot diffuse through the membrane, but the water can. Water has a concentration gradient in this system. Therefore, water will diffuse down its concentration gradient, crossing the membrane to the side where it is less concentrated. This diffusion of water through the membrane—osmosis—will continue until the concentration gradient of water goes to zero. Osmosis proceeds constantly in living systems.
-Watch this video that illustrates diffusion in hot versus cold solutions.
+Watch this video that illustrates diffusion in hot versus cold solutions.Tonicity
diff --git a/modules/m45437/index.cnxml b/modules/m45437/index.cnxml
index 6e982aaa4..2aee6c85c 100644
--- a/modules/m45437/index.cnxml
+++ b/modules/m45437/index.cnxml
@@ -64,7 +64,7 @@
Still water has potential energy; moving water, such as in a waterfall or a rapidly flowing river, has kinetic energy. (credit "dam": modification of work by "Pascal"/Flickr; credit "waterfall": modification of work by Frank Gualtieri)
Potential energy is not only associated with the location of matter, but also with the structure of matter. Even a spring on the ground has potential energy if it is compressed; so does a rubber band that is pulled taut. On a molecular level, the bonds that hold the atoms of molecules together exist in a particular structure that has potential energy. Remember that anabolic cellular pathways require energy to synthesize complex molecules from simpler ones and catabolic pathways release energy when complex molecules are broken down. The fact that energy can be released by the breakdown of certain chemical bonds implies that those bonds have potential energy. In fact, there is potential energy stored within the bonds of all the food molecules we eat, which is eventually harnessed for use. This is because these bonds can release energy when broken. The type of potential energy that exists within chemical bonds, and is released when those bonds are broken, is called chemical energy. Chemical energy is responsible for providing living cells with energy from food. The release of energy occurs when the molecular bonds within food molecules are broken.
-Visit the site and select “Pendulum” from the “Work and Energy” menu to see the shifting kinetic and potential energy of a pendulum in motion.
+Visit the site and select “Pendulum” from the “Work and Energy” menu to see the shifting kinetic and potential energy of a pendulum in motion.Free and Activation Energy
@@ -80,7 +80,7 @@
-Watch an animation of the move from free energy to transition state of the reaction.
+Watch an animation of the move from free energy to transition state of the reaction.Enzymes
@@ -93,7 +93,7 @@
For many years, scientists thought that enzyme-substrate binding took place in a simple “lock and key” fashion. This model asserted that the enzyme and substrate fit together perfectly in one instantaneous step. However, current research supports a model called induced fit (). The induced-fit model expands on the lock-and-key model by describing a more dynamic binding between enzyme and substrate. As the enzyme and substrate come together, their interaction causes a mild shift in the enzyme’s structure that forms an ideal binding arrangement between enzyme and substrate.
-View an animation of induced fit.
+View an animation of induced fit.When an enzyme binds its substrate, an enzyme-substrate complex is formed. This complex lowers the activation energy of the reaction and promotes its rapid progression in one of multiple possible ways. On a basic level, enzymes promote chemical reactions that involve more than one substrate by bringing the substrates together in an optimal orientation for reaction. Another way in which enzymes promote the reaction of their substrates is by creating an optimal environment within the active site for the reaction to occur. The chemical properties that emerge from the particular arrangement of amino acid R groups within an active site create the perfect environment for an enzyme’s specific substrates to react.The enzyme-substrate complex can also lower activation energy by compromising the bond structure so that it is easier to break. Finally, enzymes can also lower activation energies by taking part in the chemical reaction itself. In these cases, it is important to remember that the enzyme will always return to its original state by the completion of the reaction. One of the hallmark properties of enzymes is that they remain ultimately unchanged by the reactions they catalyze. After an enzyme has catalyzed a reaction, it releases its product(s) and can catalyze a new reaction.
-Watch the process of photosynthesis within a leaf in this video.
+Watch the process of photosynthesis within a leaf in this video.What Is Light Energy?The sun emits an enormous amount of electromagnetic radiation (solar energy). Humans can see only a fraction of this energy, which is referred to as “visible light.” The manner in which solar energy travels can be described and measured as waves. Scientists can determine the amount of energy of a wave by measuring its wavelength, the distance between two consecutive, similar points in a series of waves, such as from crest to crest or trough to trough ().In summary, it takes six turns of the Calvin cycle to fix six carbon atoms from CO2. These six turns require energy input from 12 ATP molecules and 12 NADPH molecules in the reduction step and 6 ATP molecules in the regeneration step.
-The following is a link to an animation of the Calvin cycle. Click Stage 1, Stage 2, and then Stage 3 to see G3P and ATP regenerate to form RuBP.
+The following is a link to an animation of the Calvin cycle. Click Stage 1, Stage 2, and then Stage 3 to see G3P and ATP regenerate to form RuBP.PhotosynthesisThe shared evolutionary history of all photosynthetic organisms is conspicuous, as the basic process has changed little over eras of time. Even between the giant tropical leaves in the rainforest and tiny cyanobacteria, the process and components of photosynthesis that use water as an electron donor remain largely the same. Photosystems function to absorb light and use electron transport chains to convert energy. The Calvin cycle reactions assemble carbohydrate molecules with this energy.
diff --git a/modules/m45461/index.cnxml b/modules/m45461/index.cnxml
index 3b3e59438..99452a27e 100644
--- a/modules/m45461/index.cnxml
+++ b/modules/m45461/index.cnxml
@@ -17,7 +17,7 @@
The cell cycle is an ordered series of events involving cell growth and cell division that produces two new daughter cells. Cells on the path to cell division proceed through a series of precisely timed and carefully regulated stages of growth, DNA replication, and division that produce two genetically identical cells. The cell cycle has two major phases: interphase and the mitotic phase (). During interphase, the cell grows and DNA is replicated. During the mitoticphase, the replicated DNA and cytoplasmic contents are separated and the cell divides.
-Watch this video about the cell cycle: http://openstax.org/l/biocellcycCytokinesisCytokinesis is the second part of the mitotic phase during which cell division is completed by the physical separation of the cytoplasmic components into two daughter cells. Although the stages of mitosis are similar for most eukaryotes, the process of cytokinesis is quite different for eukaryotes that have cell walls, such as plant cells.
diff --git a/modules/m45462/index.cnxml b/modules/m45462/index.cnxml
index cf906cfeb..d0b26b4a6 100644
--- a/modules/m45462/index.cnxml
+++ b/modules/m45462/index.cnxml
@@ -31,7 +31,7 @@
(a) The role of p53 is to monitor DNA. If damage is detected, p53 triggers repair mechanisms. If repairs are unsuccessful, p53 signals apoptosis. (b) A cell with an abnormal p53 protein cannot repair damaged DNA and cannot signal apoptosis. Cells with abnormal p53 can become cancerous. (credit: modification of work by Thierry Soussi)
-Go to this website to watch an animation of how cancer results from errors in the cell cycle.
+Go to this website to watch an animation of how cancer results from errors in the cell cycle.Since cancer is defined by uncontrolled cell growth, cancer treatments aim to interrupt the cell cycle. One of the first treatments involved folic acid, a substance discovered by Lucy Wills while she was researching pregnancy anemia (blood disorder). Several scientists showed that inhibiting folic acid uptake by tumor cells resulted in reduced growth. Jane C. Wright identified the drug now known as methotrexate as an effective treatment for breast and skin cancers. The same drug was applied to other cancers, such as placental, uterine, and lung cancers. Methotrexate is known as the first chemotherapy drug, and Wright's additional work to establish dosage protocols and sequences—both to maximize the effect and manage side effects—laid the foundation for contemporary chemotherapy treatments.
diff --git a/modules/m45466/index.cnxml b/modules/m45466/index.cnxml
index 3fd3f9b74..3882ad526 100644
--- a/modules/m45466/index.cnxml
+++ b/modules/m45466/index.cnxml
@@ -44,7 +44,7 @@
Cytokinesis, the physical separation of the cytoplasmic components into two daughter cells, occurs without reformation of the nuclei in other organisms. In nearly all species, cytokinesis separates the cell contents by either a cleavage furrow (in animals and some fungi), or a cell plate that will ultimately lead to formation of cell walls that separate the two daughter cells (in plants). At each pole, there is just one member of each pair of the homologous chromosomes, so only one full set of the chromosomes is present. This is why the cells are considered haploid—there is only one chromosome set, even though there are duplicate copies of the set because each homolog still consists of two sister chromatids that are still attached to each other. However, although the sister chromatids were once duplicates of the same chromosome, they are no longer identical at this stage because of crossovers.
-Review the process of meiosis, observing how chromosomes align and migrate, at this site.
+Review the process of meiosis, observing how chromosomes align and migrate, at this site.Meiosis II
@@ -67,7 +67,7 @@
Meiosis and mitosis are both preceded by one round of DNA replication; however, meiosis includes two nuclear divisions. The four daughter cells resulting from meiosis are haploid and genetically distinct. The daughter cells resulting from mitosis are diploid and identical to the parent cell.
-For an animation comparing mitosis and meiosis, go to this website.
+For an animation comparing mitosis and meiosis, go to this website.Section SummarySexual reproduction requires that diploid organisms produce haploid cells that can fuse during fertilization to form diploid offspring. The process that results in haploid cells is called meiosis. Meiosis is a series of events that arrange and separate chromosomes into daughter cells. During the interphase of meiosis, each chromosome is duplicated. In meiosis, there are two rounds of nuclear division resulting in four nuclei and usually four haploid daughter cells, each with half the number of chromosomes as the parent cell. During meiosis, variation in the daughter nuclei is introduced because of crossover in prophase I and random alignment at metaphase I. The cells that are produced by meiosis are genetically unique.
diff --git a/modules/m45471/index.cnxml b/modules/m45471/index.cnxml
index bb51ef4c9..9bd272680 100644
--- a/modules/m45471/index.cnxml
+++ b/modules/m45471/index.cnxml
@@ -67,7 +67,7 @@
Discoveries in fruit fly genetics can be applied to human genetics. When a female parent is homozygous for a recessive X-linked trait, the parent will pass the trait on to 100 percent of the male offspring, because the males will receive the Y chromosome from the male parent. In humans, the alleles for certain conditions (some color-blindness, hemophilia, and muscular dystrophy) are X-linked. Females who are heterozygous for these diseases are said to be carriers and may not exhibit any phenotypic effects. These females will pass the disease to half of their male offspring and will pass carrier status to half of their female offspring; therefore, X-linked traits appear more frequently in males than females.In some groups of organisms with sex chromosomes, the sex with the non-homologous sex chromosomes is the female rather than the male. This is the case for all birds. In this case, sex-linked traits will be more likely to appear in the female, in whom they are hemizygous.
- Watch this video to learn more about sex-linked traits.
+ Watch this video to learn more about sex-linked traits.Linked Genes Violate the Law of Independent Assortment
@@ -82,7 +82,7 @@
Mendel’s studies in pea plants implied that the sum of an individual’s phenotype was controlled by genes (or as he called them, unit factors), such that every characteristic was distinctly and completely controlled by a single gene. In fact, single observable characteristics are almost always under the influence of multiple genes (each with two or more alleles) acting in unison. For example, at least eight genes contribute to eye color in humans.
- Eye color in humans is determined by multiple alleles. Use the Eye Color Calculator to predict the eye color of children from parental eye color.
+ Eye color in humans is determined by multiple alleles. Use the Eye Color Calculator to predict the eye color of children from parental eye color.In some cases, several genes can contribute to aspects of a common phenotype without their gene products ever directly interacting. In the case of organ development, for instance, genes may be expressed sequentially, with each gene adding to the complexity and specificity of the organ. Genes may function in complementary or synergistic fashions, such that two or more genes expressed simultaneously affect a phenotype. An apparent example of this occurs with human skin color, which appears to involve the action of at least three (and probably more) genes. Cases in which inheritance for a characteristic like skin color or human height depend on the combined effects of numerous genes are called polygenic inheritance.Genes may also oppose each other, with one gene suppressing the expression of another. In epistasis, the interaction between genes is antagonistic, such that one gene masks or interferes with the expression of another. “Epistasis” is a word composed of Greek roots meaning “standing upon.” The alleles that are being masked or silenced are said to be hypostatic to the epistatic alleles that are doing the masking. Often the biochemical basis of epistasis is a gene pathway in which expression of one gene is dependent on the function of a gene that precedes or follows it in the pathway.An example of epistasis is pigmentation in mice. The wild-type coat color, agouti (AA) is dominant to solid-colored fur (aa). However, a separate gene C, when present as the recessive homozygote (cc), negates any expression of pigment from the A gene and results in an albino mouse (). Therefore, the genotypes AAcc, Aacc, and aacc all produce the same albino phenotype. A cross between heterozygotes for both genes (AaCc x AaCc) would generate offspring with a phenotypic ratio of 9 agouti:3 black:4 albino (). In this case, the C gene is epistatic to the A gene.
diff --git a/modules/m45473/index.cnxml b/modules/m45473/index.cnxml
index d33658e79..09961cc0c 100644
--- a/modules/m45473/index.cnxml
+++ b/modules/m45473/index.cnxml
@@ -66,7 +66,7 @@
-Watch this animation of DNA packaging.
+Watch this animation of DNA packaging.Section SummaryThe model of the double-helix structure of DNA was proposed by Watson and Crick. The DNA molecule is a polymer of nucleotides. Each nucleotide is composed of a nitrogenous base, a five-carbon sugar (deoxyribose), and a phosphate group. There are four nitrogenous bases in DNA, two purines (adenine and guanine) and two pyrimidines (cytosine and thymine). A DNA molecule is composed of two strands. Each strand is composed of nucleotides bonded together covalently between the phosphate group of one and the deoxyribose sugar of the next. From this backbone extend the bases. The bases of one strand bond to the bases of the second strand with hydrogen bonds. Adenine always bonds with thymine, and cytosine always bonds with guanine. The bonding causes the two strands to spiral around each other in a shape called a double helix. Ribonucleic acid (RNA) is a second nucleic acid found in cells. RNA is a single-stranded polymer of nucleotides. It also differs from DNA in that it contains the sugar ribose, rather than deoxyribose, and the nucleotide uracil rather than thymine. Various RNA molecules function in the process of forming proteins from the genetic code in DNA.
diff --git a/modules/m45475/index.cnxml b/modules/m45475/index.cnxml
index 9d5365b7d..ab7973c88 100644
--- a/modules/m45475/index.cnxml
+++ b/modules/m45475/index.cnxml
@@ -105,7 +105,7 @@
-Click through a tutorial on DNA replication.
+Click through a tutorial on DNA replication.
diff --git a/modules/m45479/index.cnxml b/modules/m45479/index.cnxml
index c287e5278..4ca321926 100644
--- a/modules/m45479/index.cnxml
+++ b/modules/m45479/index.cnxml
@@ -54,7 +54,7 @@
Termination of translation occurs when a stop codon (UAA, UAG, or UGA) is encountered. When the ribosome encounters the stop codon, the growing polypeptide is released and the ribosome subunits dissociate and leave the mRNA. After many ribosomes have completed translation, the mRNA is degraded so the nucleotides can be reused in another transcription reaction.
-Transcribe a gene and translate it to protein using complementary pairing and the genetic code at this site.
+Transcribe a gene and translate it to protein using complementary pairing and the genetic code at this site.Section SummaryThe central dogma describes the flow of genetic information in the cell from genes to mRNA to proteins. Genes are used to make mRNA by the process of transcription; mRNA is used to synthesize proteins by the process of translation. The genetic code is the correspondence between the three-nucleotide mRNA codon and an amino acid. The genetic code is “translated” by the tRNA molecules, which associate a specific codon with a specific amino acid. The genetic code is degenerate because 64 triplet codons in mRNA specify only 20 amino acids and three stop codons. This means that more than one codon corresponds to an amino acid. Almost every species on the planet uses the same genetic code.
diff --git a/modules/m45482/index.cnxml b/modules/m45482/index.cnxml
index 2aa38a87a..93bee3fa2 100644
--- a/modules/m45482/index.cnxml
+++ b/modules/m45482/index.cnxml
@@ -92,7 +92,7 @@
Using recombinant DNA technology to modify an organism’s DNA to achieve desirable traits is called genetic engineering. Addition of foreign DNA in the form of recombinant DNA vectors that are generated by molecular cloning is the most common method of genetic engineering. An organism that receives the recombinant DNA is called a genetically modified organism (GMO). If the foreign DNA that is introduced comes from a different species, the host organism is called transgenic. Bacteria, plants, and animals have been genetically modified since the early 1970s for academic, medical, agricultural, and industrial purposes. These applications will be examined in more detail in the next module.
-Watch this short video explaining how scientists create a transgenic animal.
+Watch this short video explaining how scientists create a transgenic animal.Although the classic methods of studying the function of genes began with a given phenotype and determined the genetic basis of that phenotype, modern techniques allow researchers to start at the DNA sequence level and ask: "What does this gene or DNA element do?" This technique, called reverse genetics, has resulted in reversing the classical genetic methodology. One example of this method is analogous to damaging a body part to determine its function. An insect that loses a wing cannot fly, which means that the wing’s function is flight. The classic genetic method compares insects that cannot fly with insects that can fly, and observes that the non-flying insects have lost wings. Similarly in a reverse genetics approach, mutating or deleting genes provides researchers with clues about gene function. Alternately, reverse genetics can be used to cause a gene to overexpress itself to determine what phenotypic effects may occur.
diff --git a/modules/m45483/index.cnxml b/modules/m45483/index.cnxml
index f2329fabd..7ee99bc68 100644
--- a/modules/m45483/index.cnxml
+++ b/modules/m45483/index.cnxml
@@ -19,7 +19,7 @@
The process of testing for suspected genetic defects before administering treatment is called genetic diagnosis by genetic testing. In some cases in which a genetic disease is present in an individual’s family, family members may be advised to undergo genetic testing. For example, mutations in the BRCA genes may increase the likelihood of developing breast, ovarian, and some other cancers. A person with breast cancer can be screened for these mutations. If one of the high-risk mutations is found, relatives may also wish to be screened for that particular mutation, or simply be more vigilant for the occurrence of cancers. Genetic testing is also offered for fetuses (or embryos with in vitro fertilization) to determine the presence or absence of disease-causing genes in families with specific debilitating diseases.
-See how human DNA is extracted for uses such as genetic testing.Gene therapy is a genetic engineering technique that may one day be used to cure certain genetic diseases. In its simplest form, it involves the introduction of a non-mutated gene at a random location in the genome to cure a disease by replacing a protein that may be absent in these individuals because of a genetic mutation. The non-mutated gene is usually introduced into diseased cells as part of a vector transmitted by a virus, such as an adenovirus, that can infect the host cell and deliver the foreign DNA into the genome of the targeted cell (). To date, gene therapies have been primarily experimental procedures in humans. A few of these experimental treatments have been successful, but the methods may be important in the future as the factors limiting its success are resolved.
+See how human DNA is extracted for uses such as genetic testing.Gene therapy is a genetic engineering technique that may one day be used to cure certain genetic diseases. In its simplest form, it involves the introduction of a non-mutated gene at a random location in the genome to cure a disease by replacing a protein that may be absent in these individuals because of a genetic mutation. The non-mutated gene is usually introduced into diseased cells as part of a vector transmitted by a virus, such as an adenovirus, that can infect the host cell and deliver the foreign DNA into the genome of the targeted cell (). To date, gene therapies have been primarily experimental procedures in humans. A few of these experimental treatments have been successful, but the methods may be important in the future as the factors limiting its success are resolved.
diff --git a/modules/m45485/index.cnxml b/modules/m45485/index.cnxml
index 62ed362a7..5b4811fdf 100644
--- a/modules/m45485/index.cnxml
+++ b/modules/m45485/index.cnxml
@@ -26,7 +26,7 @@
This is a physical map of the human X chromosome. (credit: modification of work by NCBI, NIH)
Genetic maps provide the outline, and physical maps provide the details. It is easy to understand why both types of genome-mapping techniques are important to show the big picture. Information obtained from each technique is used in combination to study the genome. Genomic mapping is used with different model organisms that are used for research. Genome mapping is still an ongoing process, and as more advanced techniques are developed, more advances are expected. Genome mapping is similar to completing a complicated puzzle using every piece of available data. Mapping information generated in laboratories all over the world is entered into central databases, such as the National Center for Biotechnology Information (NCBI). Efforts are made to make the information more easily accessible to researchers and the general public. Just as we use global positioning systems instead of paper maps to navigate through roadways, NCBI allows us to use a genome viewer tool to simplify the data mining process.
-Online Mendelian Inheritance in Man (OMIM) is a searchable online catalog of human genes and genetic disorders. This website shows genome mapping, and also details the history and research of each trait and disorder. Click the link to search for traits (such as handedness) and genetic disorders (such as diabetes).
+Online Mendelian Inheritance in Man (OMIM) is a searchable online catalog of human genes and genetic disorders. This website shows genome mapping, and also details the history and research of each trait and disorder. Click the link to search for traits (such as handedness) and genetic disorders (such as diabetes).Whole Genome Sequencing
diff --git a/modules/m45489/index.cnxml b/modules/m45489/index.cnxml
index 38a47160c..0c76cd16e 100644
--- a/modules/m45489/index.cnxml
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@@ -37,7 +37,7 @@
A chance event or catastrophe can reduce the genetic variability within a population.
Another scenario in which populations might experience a strong influence of genetic drift is if some portion of the population leaves to start a new population in a new location, or if a population gets divided by a physical barrier of some kind. In this situation, those individuals are unlikely to be representative of the entire population which results in the founder effect. The founder effect occurs when the genetic structure matches that of the new population’s founding fathers and mothers. The founder effect is believed to have been a key factor in the genetic history of the Afrikaner population of Dutch settlers in South Africa, as evidenced by mutations that are common in Afrikaners but rare in most other populations. This is likely due to a higher-than-normal proportion of the founding colonists, which were a small sample of the original population, carried these mutations. As a result, the population expresses unusually high incidences of Huntington’s disease (HD) and Fanconi anemia (FA), a genetic disorder known to cause bone marrow and congenital abnormalities, and even cancer.A. J. Tipping et al., “Molecular and Genealogical Evidence for a Founder Effect in Fanconi Anemia Families of the Afrikaner Population of South Africa,” PNAS 98, no. 10 (2001): 5734-5739, doi: 10.1073/pnas.091402398.
-Visit this site to learn more about genetic drift and to run simulations of allele changes caused by drift.
+Visit this site to learn more about genetic drift and to run simulations of allele changes caused by drift.Gene FlowAnother important evolutionary force is gene flow, or the flow of alleles in and out of a population resulting from the migration of individuals or gametes (). While some populations are fairly stable, others experience more flux. Many plants, for example, send their seeds far and wide, by wind or in the guts of animals; these seeds may introduce alleles common in the source population to a new population in which they are rare.
diff --git a/modules/m45491/index.cnxml b/modules/m45491/index.cnxml
index ec6bef5d8..6d28f6924 100644
--- a/modules/m45491/index.cnxml
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@@ -27,7 +27,7 @@
The similar construction of these appendages indicates that these organisms share a common ancestor.
-Click through the activities at this interactive site to guess which bone structures are homologous and which are analogous, and to see examples of all kinds of evolutionary adaptations that illustrate these concepts.
+Click through the activities at this interactive site to guess which bone structures are homologous and which are analogous, and to see examples of all kinds of evolutionary adaptations that illustrate these concepts.Another piece of evidence of evolution is the convergence of form in organisms that share similar environments. For example, species of unrelated animals, such as the arctic fox and ptarmigan (a bird), living in the arctic region have temporary white coverings during winter to blend with the snow and ice (). The similarity occurs not because of common ancestry, indeed one covering is of fur and the other of feathers, but because of similar selection pressures—the benefits of not being seen by predators.
diff --git a/modules/m45493/index.cnxml b/modules/m45493/index.cnxml
index dc8cd6b5f..2ac8c32db 100644
--- a/modules/m45493/index.cnxml
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@@ -37,7 +37,7 @@
The honeycreeper birds illustrate adaptive radiation. From one original species of bird, multiple others evolved, each with its own distinctive characteristics.
Notice the differences in the species’ beaks in . Change in the genetic variation for beaks in response to natural selection based on specific food sources in each new habitat led to evolution of a different beak suited to the specific food source. The fruit and seed-eating birds have thicker, stronger beaks which are suited to break hard nuts. The nectar-eating birds have long beaks to dip into flowers to reach their nectar. The insect-eating birds have beaks like swords, appropriate for stabbing and impaling insects. Darwin’s finches are another well-studied example of adaptive radiation in an archipelago.
-Click through this interactive site to see how island birds evolved; click to see images of each species in evolutionary increments from five million years ago to today.
+Click through this interactive site to see how island birds evolved; click to see images of each species in evolutionary increments from five million years ago to today.Speciation without Geographic Separation
diff --git a/modules/m45505/index.cnxml b/modules/m45505/index.cnxml
index 1a230a60c..83e473b01 100644
--- a/modules/m45505/index.cnxml
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@@ -16,7 +16,7 @@
Although the theory of evolution initially generated some controversy, by 20 years after the publication of On theOrigin of Species it was almost universally accepted by biologists, particularly younger biologists. Nevertheless, the theory of evolution is a difficult concept and misconceptions about how it works abound. In addition, there are those that reject it as an explanation for the diversity of life.
-This website addresses some of the main misconceptions associated with the theory of evolution.
+This website addresses some of the main misconceptions associated with the theory of evolution. Evolution Is Just a TheoryCritics of the theory of evolution dismiss its importance by purposefully confounding the everyday usage of the word “theory” with the way scientists use the word. In science, a “theory” is understood to be a concept that has been extensively tested and supported over time. We have a theory of the atom, a theory of gravity, and the theory of relativity, each of which describes what scientists understand to be facts about the world. In the same way, the theory of evolution describes facts about the living world. As such, a theory in science has survived significant efforts to discredit it by scientists, who are naturally skeptical. While theories can sometimes be overturned or revised, this does not lessen their weight but simply reflects the constantly evolving state of scientific knowledge. In contrast, a “theory” in common vernacular means a guess or suggested explanation for something. This meaning is more akin to the concept of a “hypothesis” used by scientists, which is a tentative explanation for something that is proposed to either be supported or disproved. When critics of evolution say evolution is “just a theory,” they are implying that there is little evidence supporting it and that it is still in the process of being rigorously tested. This is a mischaracterization. If this were the case, geneticist Theodosius Dobzhansky would not have said that “nothing in biology makes sense, except in the light of evolution.”Theodosius Dobzhansky. “Biology, Molecular and Organismic.” American Zoologist 4, no. 4 (1964): 449.
diff --git a/modules/m45507/index.cnxml b/modules/m45507/index.cnxml
index abcbb18a9..2f4b30120 100644
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@@ -52,7 +52,7 @@
This phylogenetic tree is rooted by an organism that lacked a vertebral column. At each branch point, organisms with different characters are placed in different groups.
-This interactive exercise allows you to explore the evolutionary relationships among species.
+This interactive exercise allows you to explore the evolutionary relationships among species.Limitations of Phylogenetic Trees
diff --git a/modules/m45509/index.cnxml b/modules/m45509/index.cnxml
index cb7d65797..d1603cb36 100644
--- a/modules/m45509/index.cnxml
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@@ -62,7 +62,7 @@
To aid in the tremendous task of choosing the best tree, scientists often use a concept called maximum parsimony, which means that events occurred in the simplest, most obvious way. This means that the “best” tree is the one with the fewest number of character reversals, the fewest number of independent character changes, and the fewest number of character changes throughout the tree. Computer programs search through all of the possible trees to find the small number of trees with the simplest evolutionary pathways. Starting with all of the homologous traits in a group of organisms, scientists can determine the order of evolutionary events of which those traits occurred that is the most obvious and simple.
-Practice Parsimony: Go to this website to learn how maximum parsimony is used to create phylogenetic trees (be sure to continue to the second page).
+Practice Parsimony: Go to this website to learn how maximum parsimony is used to create phylogenetic trees (be sure to continue to the second page).These tools and concepts are only a few of the strategies scientists use to tackle the task of revealing the evolutionary history of life on Earth. Recently, newer technologies have uncovered surprising discoveries with unexpected relationships, such as the fact that people seem to be more closely related to fungi than fungi are to plants. Sound unbelievable? As the information about DNA sequences grows, scientists will become closer to mapping the evolutionary history of all life on Earth.
diff --git a/modules/m45512/index.cnxml b/modules/m45512/index.cnxml
index 32f215b33..71639039d 100644
--- a/modules/m45512/index.cnxml
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@@ -86,7 +86,7 @@
One of the most devastating pandemics was the Black Death (1346 to 1361), which is believed to have been another outbreak of bubonic plague caused by the bacterium Yersinia pestis. This bacterium is carried by fleas living on black rats. The Black Death reduced the world’s population from an estimated 450 million to about 350 to 375 million. Bubonic plague struck London hard again in the mid-1600s. There are still approximately 1,000 to 3,000 cases of plague globally each year. Although contracting bubonic plague before antibiotics meant almost certain death, the bacterium responds to several types of modern antibiotics, and mortality rates from plague are now very low.
- Watch a video on the modern understanding of the Black Death (bubonic plague) in Europe during the fourteenth century.
+ Watch a video on the modern understanding of the Black Death (bubonic plague) in Europe during the fourteenth century.Over the centuries, Europeans developed resistance to many infectious diseases. However, European conquerors brought disease-causing bacteria and viruses with them when they reached the Western hemisphere, triggering epidemics that completely devastated populations of Native Americans (who had no natural resistance to many European diseases).
@@ -95,7 +95,7 @@
Another problem is the excessive use of antibiotics in livestock. The routine use of antibiotics in animal feed promotes bacterial resistance as well. In the United States, 70 percent of the antibiotics produced are fed to animals. The antibiotics are not used to prevent disease, but to enhance production of their products.
- Watch an overview report on the problem of routine antibiotic administration to livestock and antibiotic-resistant bacteria.Staphylococcus aureus, often called “staph,” is a common bacterium that can live in and on the human body, which usually is easily treatable with antibiotics. A very dangerous strain, however, has made the news over the past few years (). This strain, methicillin-resistant Staphylococcus aureus (MRSA), is resistant to many commonly used antibiotics, including methicillin, amoxicillin, penicillin, and oxacillin. While MRSA infections have been common among people in healthcare facilities, it is appearing more commonly in healthy people who live or work in dense groups (like military personnel and prisoners). The Journal of the American Medical Association reported that, among MRSA-afflicted persons in healthcare facilities, the average age is 68 years, while people with “community-associated MRSA” (CA-MRSA) have an average age of 23 years.Naimi, T. S., LeDell, K. H., Como-Sabetti, K., et al., “Comparison of community- and health care-associated methicillin-resistant Staphylococcus aureus infection,” JAMA 290 (2003): 2976-2984, doi: 10.1001/jama.290.22.2976.
+ Watch an overview report on the problem of routine antibiotic administration to livestock and antibiotic-resistant bacteria.Staphylococcus aureus, often called “staph,” is a common bacterium that can live in and on the human body, which usually is easily treatable with antibiotics. A very dangerous strain, however, has made the news over the past few years (). This strain, methicillin-resistant Staphylococcus aureus (MRSA), is resistant to many commonly used antibiotics, including methicillin, amoxicillin, penicillin, and oxacillin. While MRSA infections have been common among people in healthcare facilities, it is appearing more commonly in healthy people who live or work in dense groups (like military personnel and prisoners). The Journal of the American Medical Association reported that, among MRSA-afflicted persons in healthcare facilities, the average age is 68 years, while people with “community-associated MRSA” (CA-MRSA) have an average age of 23 years.Naimi, T. S., LeDell, K. H., Como-Sabetti, K., et al., “Comparison of community- and health care-associated methicillin-resistant Staphylococcus aureus infection,” JAMA 290 (2003): 2976-2984, doi: 10.1001/jama.290.22.2976.
diff --git a/modules/m45519/index.cnxml b/modules/m45519/index.cnxml
index 59d82589d..dcd0d9498 100644
--- a/modules/m45519/index.cnxml
+++ b/modules/m45519/index.cnxml
@@ -39,7 +39,7 @@
-Watch this video to see the process of seed production in gymnosperms.
+Watch this video to see the process of seed production in gymnosperms.
@@ -74,7 +74,7 @@
Ephedra viridis, known by the common name Mormon tea, grows in the western United States. (credit: US National Park Service, USDA-NRCS PLANTS Database)
-Watch this BBC video describing the amazing strangeness of Welwitschia.
+Watch this BBC video describing the amazing strangeness of Welwitschia.
diff --git a/modules/m45520/index.cnxml b/modules/m45520/index.cnxml
index b22cd9e5c..27d098ede 100644
--- a/modules/m45520/index.cnxml
+++ b/modules/m45520/index.cnxml
@@ -120,7 +120,7 @@
-Explore this website for more information on pollinators.
+Explore this website for more information on pollinators.The Role of Seed Plants
Without seed plants, life as we know it would not be possible. Plants play a key role in the maintenance of terrestrial ecosystems through the stabilization of soils, cycling of carbon, and climate moderation. Large tropical forests release oxygen and act as carbon dioxide “sinks.” Seed plants provide shelter to many life forms, as well as food for herbivores, thereby indirectly feeding carnivores. Plant secondary metabolites are used for medicinal purposes and industrial production. Virtually all animal life is dependent on plants for survival.
diff --git a/modules/m45523/index.cnxml b/modules/m45523/index.cnxml
index 28bd4fd7c..b12ad7da9 100644
--- a/modules/m45523/index.cnxml
+++ b/modules/m45523/index.cnxml
@@ -24,7 +24,7 @@
A hallmark trait of animals is specialized structures that are differentiated to perform unique functions. As multicellular organisms, most animals develop specialized cells that group together into tissues with specialized functions. A tissue is a collection of similar cells that had a common embryonic origin. There are four main types of animal tissues: nervous, muscle, connective, and epithelial. Nervous tissue contains neurons, or nerve cells, which transmit nerve impulses. Muscle tissue contracts to cause all types of body movement from locomotion of the organism to movements within the body itself. Animals also have specialized connective tissues that provide many functions, including transport and structural support. Examples of connective tissues include blood and bone. Connective tissue is comprised of cells separated by extracellular material made of organic and inorganic materials, such as the protein and mineral deposits of bone. Epithelial tissue covers the internal and external surfaces of organs inside the animal body and the external surface of the body of the organism.
-View this video to watch a presentation by biologist E.O. Wilson on the importance of animal diversity.
+View this video to watch a presentation by biologist E.O. Wilson on the importance of animal diversity.Animal Reproduction and Development
@@ -63,7 +63,7 @@
Bilateral symmetry is illustrated in c using a goat. The goat also has upper and lower sides to it, but they are not symmetrical. A vertical plane cut from front to back separates the animal into roughly mirror-image right and left sides. Animals with bilateral symmetry also have a “head” and “tail” (anterior versus posterior) and a back and underside (dorsal versus ventral).
- Watch this video to see a quick sketch of the different types of body symmetry.
+ Watch this video to see a quick sketch of the different types of body symmetry.Layers of TissuesMost animal species undergo a layering of early tissues during embryonic development. These layers are called germ layers. Each layer develops into a specific set of tissues and organs. Animals develop either two or three embryonic germs layers (). The animals that display radial symmetry develop two germ layers, an inner layer (endoderm) and an outer layer (ectoderm). These animals are called diploblasts. Animals with bilateral symmetry develop three germ layers: an inner layer (endoderm), an outer layer (ectoderm), and a middle layer (mesoderm). Animals with three germ layers are called triploblasts.
diff --git a/modules/m45524/index.cnxml b/modules/m45524/index.cnxml
index 88064437e..bdc22c927 100644
--- a/modules/m45524/index.cnxml
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@@ -34,7 +34,7 @@
Sponges are monoecious (or hermaphroditic), meaning one individual can produce both eggs and sperm. Sponges may be sequentially hermaphroditic, producing eggs first and sperm later. Eggs arise from amoebocytes and are retained within the spongocoel, whereas sperm arise from choanocytes and are ejected through the osculum. Sperm carried by water currents fertilize the eggs of other sponges. Early larval development occurs within the sponge, and free-swimming larvae are then released through the osculum. This is the only time that sponges exhibit mobility. Sponges are sessile as adults and spend their lives attached to a fixed substrate.
- Watch this video that demonstrates the feeding of sponges.
+ Watch this video that demonstrates the feeding of sponges.Cnidarians
@@ -68,7 +68,7 @@
Use this video to identify the life cycle stages of jellies.The class Cubozoa includes jellies that are square in cross-section and so are known as “box jellyfish.” These species may achieve sizes of 15–25 cm. Cubozoans are anatomically similar to the jellyfish. A prominent difference between the two classes is the arrangement of tentacles. Cubozoans have muscular pads called pedalia at the corners of the square bell canopy, with one or more tentacles attached to each pedalium. In some cases, the digestive system may extend into the pedalia. Cubozoans typically exist in a polyp form that develops from a larva. The polyps may bud to form more polyps and then transform into the medusoid forms.
- Watch this video to learn more about the deadly toxins of the box jellyfish.
+ Watch this video to learn more about the deadly toxins of the box jellyfish.Hydrozoa includes nearly 3,500 species,“The Hydrozoa Directory,” Peter Schuchert, Muséum Genève, last updated November 2012, http://www.ville-ge.ch/mhng/hydrozoa/hydrozoa-directory.htm. most of which are marine. Most species in this class have both polyp and medusa forms in their life cycle. Many hydrozoans form colonies composed of branches of specialized polyps that share a gastrovascular cavity. Colonies may also be free-floating and contain both medusa and polyp individuals in the colony, as in the Portuguese Man O’War (Physalia) or By-the-Wind Sailor (Velella). Other species are solitary polyps or solitary medusae. The characteristic shared by all of these species is that their gonads are derived from epidermal tissue, whereas in all other cnidarians, they are derived from gastrodermal tissue (ab).
diff --git a/modules/m45525/index.cnxml b/modules/m45525/index.cnxml
index fa5d7f71a..dc28df2de 100644
--- a/modules/m45525/index.cnxml
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@@ -50,7 +50,7 @@
Most nematodes have four nerve cords that run along the length of the body on the top, bottom, and sides. The nerve cords fuse in a ring around the pharynx, to form a head ganglion or “brain” of the worm, as well as at the posterior end to form the tail ganglion. Beneath the epidermis lies a layer of longitudinal muscles that permits only side-to-side, wave-like undulation of the body.
- View this video to see nematodes move about and feed on bacteria.
+ View this video to see nematodes move about and feed on bacteria.Nematodes employ a diversity of sexual reproductive strategies depending on the species; they may be monoecious, dioecious (separate sexes), or may reproduce asexually by parthenogenesis. Caenorhabditis elegans is nearly unique among animals in having both self-fertilizing hermaphrodites and a male sex that can mate with the hermaphrodite.
@@ -87,7 +87,7 @@
(a) The chelicerae (first set of appendages, circled) are well developed in the Chelicerata, which includes scorpions (a) and spiders (b). (credit a: modification of work by Kevin Walsh; credit b: modification of work by Marshal Hedin)
- Click through this lesson on arthropods to explore interactive habitat maps and more.
+ Click through this lesson on arthropods to explore interactive habitat maps and more.Section SummaryFlatworms are acoelomate, triploblastic animals. They lack circulatory and respiratory systems, and have a rudimentary excretory system. The digestive system is incomplete in most species. There are four traditional classes of flatworms, the largely free-living turbellarians, the ectoparasitic monogeneans, and the endoparasitic trematodes and cestodes. Trematodes have complex life cycles involving a secondary mollusk host and a primary host in which sexual reproduction takes place. Cestodes, or tapeworms, infect the digestive systems of primary vertebrate hosts.
diff --git a/modules/m45526/index.cnxml b/modules/m45526/index.cnxml
index fec003c83..a81b87548 100644
--- a/modules/m45526/index.cnxml
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@@ -44,7 +44,7 @@
Class Bivalvia (“two shells”) includes clams, oysters, mussels, scallops, and geoducks. They are found in marine and freshwater habitats. As the name suggests, bivalves are enclosed in a pair of shells (or valves) that are hinged at the dorsal side. The body is flattened on the sides. They feed by filtering particles from water and a radula is absent. They exchange gases using a pair of ctenidia, and excretion and osmoregulation are carried out by a pair of nephridia. In some species, the posterior edges of the mantle may fuse to form two siphons that inhale and exhale water. Some bivalves like oysters and mussels have the unique ability to secrete and deposit a calcareous nacre or “mother of pearl” around foreign particles that enter the mantle cavity. This property is commercially exploited to produce pearls.
- Watch animations of clams and mussels feeding to understand more about bivalves.
+ Watch animations of clams and mussels feeding to understand more about bivalves.Gastropods (“stomach foot”) include well-known mollusks like snails, slugs, conchs, sea hares, and sea butterflies. Gastropods include shell-bearing species as well as species with a reduced shell. These animals are asymmetrical and usually present a coiled shell ().
@@ -76,7 +76,7 @@
Annelids may be either monoecious with permanent gonads (as in earthworms and leeches) or dioecious with temporary or seasonal gonads (as in polychaetes).
- This video and animation provides a close-up look at annelid anatomy.
+ This video and animation provides a close-up look at annelid anatomy.Annelid Diversity
diff --git a/modules/m45531/index.cnxml b/modules/m45531/index.cnxml
index 3f8fcce41..696e74a29 100644
--- a/modules/m45531/index.cnxml
+++ b/modules/m45531/index.cnxml
@@ -31,7 +31,7 @@
This phylum is divided into five classes: Asteroidea (sea stars), Ophiuroidea (brittle stars), Echinoidea (sea urchins and sand dollars), Crinoidea (sea lilies or feather stars), and Holothuroidea (sea cucumbers) ().Perhaps the best-known echinoderms are members of the class Asteroidea, or sea stars. They come in a large variety of shapes, colors, and sizes, with more than 1,800 species known. The characteristics of sea stars that set them apart from other echinoderm classes include thick arms that extend from a central disk where organs penetrate into the arms. Sea stars use their tube feet not only for gripping surfaces but also for grasping prey. Sea stars have two stomachs, one of which they can evert through their mouths to secrete digestive juices into or onto prey before ingestion. This process can essentially liquefy the prey and make digestion easier.
- View this video to explore a sea star’s body plan up close, watch one move across the sea floor, and see it devour a mussel.
+ View this video to explore a sea star’s body plan up close, watch one move across the sea floor, and see it devour a mussel.Brittle stars have long, thin arms that do not contain any organs. Sea urchins and sand dollars do not have arms but are hemispherical or flattened with five rows of tube feet, which help them in slow movement. Sea lilies and feather stars are stalked suspension feeders. Sea cucumbers are soft-bodied and elongate with five rows of tube feet and a series of tube feet around the mouth that are modified into tentacles used in feeding.
diff --git a/modules/m45534/index.cnxml b/modules/m45534/index.cnxml
index 1e8ae1be2..2367190ed 100644
--- a/modules/m45534/index.cnxml
+++ b/modules/m45534/index.cnxml
@@ -26,7 +26,7 @@
An animal that maintains a constant body temperature in the face of environmental changes is called an endotherm. These animals are able to maintain a level of activity that an ectothermic animal cannot because they generate internal heat that keeps their cellular processes operating optimally even when the environment is cold.
- Watch this Discovery Channel video on thermoregulation to see illustrations of the process in a variety of animals.
+ Watch this Discovery Channel video on thermoregulation to see illustrations of the process in a variety of animals.Animals conserve or dissipate heat in a variety of ways. Endothermic animals have some form of insulation. They have fur, fat, or feathers. Animals with thick fur or feathers create an insulating layer of air between their skin and internal organs. Polar bears and seals live and swim in a subfreezing environment and yet maintain a constant, warm, body temperature. The arctic fox, for example, uses its fluffy tail as extra insulation when it curls up to sleep in cold weather. Mammals can increase body heat production by shivering, which is an involuntary increase in muscle activity. In addition, arrector pili muscles can contract causing individual hairs to stand up when the individual is cold. This increases the insulating effect of the hair. Humans retain this reaction, which does not have the intended effect on our relatively hairless bodies; it causes “goose bumps” instead. Mammals use layers of fat as insulation also. Loss of significant amounts of body fat will compromise an individual’s ability to conserve heat.Ectotherms and endotherms use their circulatory systems to help maintain body temperature. Vasodilation, the opening up of arteries to the skin by relaxation of their smooth muscles, brings more blood and heat to the body surface, facilitating radiation and evaporative heat loss, cooling the body. Vasoconstriction, the narrowing of blood vessels to the skin by contraction of their smooth muscles, reduces blood flow in peripheral blood vessels, forcing blood toward the core and vital organs, conserving heat. Some animals have adaptions to their circulatory system that enable them to transfer heat from arteries to veins that are flowing next to each other, warming blood returning to the heart. This is called a countercurrent heat exchange; it prevents the cold venous blood from cooling the heart and other internal organs. The countercurrent adaptation is found in dolphins, sharks, bony fish, bees, and hummingbirds.Some ectothermic animals use changes in their behavior to help regulate body temperature. They simply seek cooler areas during the hottest part of the day in the desert to keep from getting too warm. The same animals may climb onto rocks in the evening to capture heat on a cold desert night before entering their burrows.
diff --git a/modules/m45535/index.cnxml b/modules/m45535/index.cnxml
index 4d9fa5387..5c2a6dd71 100644
--- a/modules/m45535/index.cnxml
+++ b/modules/m45535/index.cnxml
@@ -83,7 +83,7 @@
For humans, a balanced diet includes fruits, vegetables, grains, protein, and dairy. (credit: USDA)
- Explore this interactive United States Department of Agriculture website to learn more about each food group and the recommended daily amounts.The organic molecules required for building cellular material and tissues must come from food. During digestion, digestible carbohydrates are ultimately broken down into glucose and used to provide energy within the cells of the body. Complex carbohydrates, including polysaccharides, can be broken down into glucose through biochemical modification; however, humans do not produce the enzyme necessary to digest cellulose (fiber). The intestinal flora in the human gut are able to extract some nutrition from these plant fibers. These plant fibers are known as dietary fiber and are an important component of the diet. The excess sugars in the body are converted into glycogen and stored for later use in the liver and muscle tissue. Glycogen stores are used to fuel prolonged exertions, such as long-distance running, and to provide energy during food shortage. Fats are stored under the skin of mammals for insulation and energy reserves.
+ Explore this interactive United States Department of Agriculture website to learn more about each food group and the recommended daily amounts.The organic molecules required for building cellular material and tissues must come from food. During digestion, digestible carbohydrates are ultimately broken down into glucose and used to provide energy within the cells of the body. Complex carbohydrates, including polysaccharides, can be broken down into glucose through biochemical modification; however, humans do not produce the enzyme necessary to digest cellulose (fiber). The intestinal flora in the human gut are able to extract some nutrition from these plant fibers. These plant fibers are known as dietary fiber and are an important component of the diet. The excess sugars in the body are converted into glycogen and stored for later use in the liver and muscle tissue. Glycogen stores are used to fuel prolonged exertions, such as long-distance running, and to provide energy during food shortage. Fats are stored under the skin of mammals for insulation and energy reserves.Proteins in food are broken down during digestion and the resulting amino acids are absorbed. All of the proteins in the body must be formed from these amino-acid constituents; no proteins are obtained directly from food.Fats add flavor to food and promote a sense of satiety or fullness. Fatty foods are also significant sources of energy, and fatty acids are required for the construction of lipid membranes. Fats are also required in the diet to aid the absorption of fat-soluble vitamins and the production of fat-soluble hormones.While the animal body can synthesize many of the molecules required for function from precursors, there are some nutrients that must be obtained from food. These nutrients are termed essential nutrients, meaning they must be eaten, because the body cannot produce them.
diff --git a/modules/m45536/index.cnxml b/modules/m45536/index.cnxml
index 198ff031d..12032b75e 100644
--- a/modules/m45536/index.cnxml
+++ b/modules/m45536/index.cnxml
@@ -40,7 +40,7 @@
- Watch this video for a review of the respiratory system.
+ Watch this video for a review of the respiratory system.The Circulatory System
@@ -74,7 +74,7 @@
The electrical impulses in the heart produce electrical currents that flow through the body and can be measured on the skin using electrodes. This information can be observed as an electrocardiogram (ECG) a recording of the electrical impulses of the cardiac muscle.
- Visit this site and select the dropdown “Your Heart’s Electrical System” to see the heart’s pacemaker, or electrocardiogram system, in action.
+ Visit this site and select the dropdown “Your Heart’s Electrical System” to see the heart’s pacemaker, or electrocardiogram system, in action.Blood VesselsThe blood from the heart is carried through the body by a complex network of blood vessels (). Arteries take blood away from the heart. The main artery of the systemic circulation is the aorta; it branches into major arteries that take blood to different limbs and organs. The aorta and arteries near the heart have heavy but elastic walls that respond to and smooth out the pressure differences caused by the beating heart. Arteries farther away from the heart have more muscle tissue in their walls that can constrict to affect flow rates of blood. The major arteries diverge into minor arteries, and then smaller vessels called arterioles, to reach more deeply into the muscles and organs of the body.
diff --git a/modules/m45538/index.cnxml b/modules/m45538/index.cnxml
index 284651e73..a48324617 100644
--- a/modules/m45538/index.cnxml
+++ b/modules/m45538/index.cnxml
@@ -22,7 +22,7 @@
The human skeleton is an endoskeleton that consists of 206 bones in the adult. An endoskeleton develops within the body rather than outside like the exoskeleton of insects. The skeleton has five main functions: providing support to the body, storing minerals and lipids, producing blood cells, protecting internal organs, and allowing for movement. The skeletal system in vertebrates is divided into the axial skeleton (which consists of the skull, vertebral column, and rib cage), and the appendicular skeleton (which consists of limb bones, the pectoral or shoulder girdle, and the pelvic girdle).
- Explore the human skeleton by viewing the following video with digital 3D sculpturing.
+ Explore the human skeleton by viewing the following video with digital 3D sculpturing.The axial skeleton forms the central axis of the body and includes the bones of the skull, ossicles of the middle ear, hyoid bone of the throat, vertebral column, and the thoracic cage (rib cage) ().
@@ -79,7 +79,7 @@ Rheumatologists are medical doctors who specialize in the diagnosis and treatmen
The thick and thin filaments alternate with each other in a structure called a sarcomere. The sarcomere is the unit of contraction in a muscle cell. Contraction is stimulated by an electrochemical signal from a nerve cell associated with the muscle fiber. For a muscle cell to contract, the sarcomere must shorten. However, thick and thin filaments do not shorten. Instead, they slide by one another, causing the sarcomere to shorten while the filaments remain the same length. The sliding is accomplished when a molecular extension of myosin, called the myosin head, temporarily binds to an actin filament next to it and through a change in conformation, bends, dragging the two filaments in opposite directions. The myosin head then releases its actin filament, relaxes, and then repeats the process, dragging the two filaments further along each other. The combined activity of many binding sites and repeated movements within the sarcomere causes it to contract. The coordinated contractions of many sarcomeres in a myofibril leads to contraction of the entire muscle cell and ultimately the muscle itself. The movement of the myosin head requires ATP, which provides the energy for the contraction.
- View this animation to see how muscle fibers are organized.
+ View this animation to see how muscle fibers are organized.Section SummaryThe human skeleton is an endoskeleton that is composed of the axial and appendicular skeleton. The axial skeleton is composed of the bones of the skull, ossicles of the ear, hyoid bone, vertebral column, and ribcage. The skull consists of eight cranial bones and 14 facial bones. Six bones make up the ossicles of the middle ear, while the hyoid bone is located in the neck under the mandible. The vertebral column contains 26 bones and surrounds and protects the spinal cord. The thoracic cage consists of the sternum, ribs, thoracic vertebrae, and costal cartilages. The appendicular skeleton is made up of the upper and lower limbs. The pectoral girdle is composed of the clavicles and the scapulae. The upper limb contains 30 bones in the arm, the forearm, and the hand. The pelvic girdle attaches the lower limbs to the axial skeleton. The lower limb includes the bones of the thigh, the leg, and the foot.
diff --git a/modules/m45539/index.cnxml b/modules/m45539/index.cnxml
index b6378906d..b0f078f21 100644
--- a/modules/m45539/index.cnxml
+++ b/modules/m45539/index.cnxml
@@ -45,7 +45,7 @@ At one time, scientists believed that people were born with all the neurons they
This image shows new neurons in a rat hippocampus. New neurons tagged with BrdU glow red in this micrograph. (credit: modification of work by Dr. Maryam Faiz, University of Barcelona)
- Visit this link interactive lab to see more information about neurogenesis, including an interactive laboratory simulation and a video that explains how BrdU labels new cells.
+ Visit this link interactive lab to see more information about neurogenesis, including an interactive laboratory simulation and a video that explains how BrdU labels new cells.While glial cells are often thought of as the supporting cast of the nervous system, the number of glial cells in the brain actually outnumbers the number of neurons by a factor of 10. Neurons would be unable to function without the vital roles that are fulfilled by these glial cells. Glia guide developing neurons to their destinations, buffer ions and chemicals that would otherwise harm neurons, and provide myelin sheaths around axons. When glia do not function properly, the result can be disastrous—most brain tumors are caused by mutations in glia.
@@ -65,7 +65,7 @@ At one time, scientists believed that people were born with all the neurons they
In other surgeries to treat severe epilepsy, the corpus callosum is cut instead of removing an entire hemisphere. This causes a condition called split-brain, which gives insights into unique functions of the two hemispheres. For example, when an object is presented to patients’ left visual field, they may be unable to verbally name the object (and may claim to not have seen an object at all). This is because the visual input from the left visual field crosses and enters the right hemisphere and cannot then signal to the speech center, which generally is found in the left side of the brain. Remarkably, if a split-brain patient is asked to pick up a specific object out of a group of objects with the left hand, the patient will be able to do so but will still be unable to verbally identify it.
- Visit the following website to learn more about split-brain patients and to play a game where you can model split-brain experiments yourself.
+ Visit the following website to learn more about split-brain patients and to play a game where you can model split-brain experiments yourself.Each hemisphere contains regions called lobes that are involved in different functions. Each hemisphere of the mammalian cerebral cortex can be broken down into four functionally and spatially defined lobes: frontal, parietal, temporal, and occipital ().
diff --git a/modules/m45541/index.cnxml b/modules/m45541/index.cnxml
index 476a9f788..59ae00217 100644
--- a/modules/m45541/index.cnxml
+++ b/modules/m45541/index.cnxml
@@ -59,7 +59,7 @@
A virus attaches to a specific receptor site on the host-cell membrane through attachment proteins in the capsid or proteins embedded in its envelope. The attachment is specific, and typically a virus will only attach to cells of one or a few species and only certain cell types within those species with the appropriate receptors.
- View this video for a visual explanation of how influenza attacks the body.
+ View this video for a visual explanation of how influenza attacks the body.Unlike animal viruses, the nucleic acid of bacteriophages is injected into the host cell naked, leaving the capsid outside the cell. Plant and animal viruses can enter their cells through endocytosis, in which the cell membrane surrounds and engulfs the entire virus. Some enveloped viruses enter the cell when the viral envelope fuses directly with the cell membrane. Once inside the cell, the viral capsid is degraded and the viral nucleic acid is released, which then becomes available for replication and transcription.The replication mechanism depends on the viral genome. DNA viruses usually use host cell proteins and enzymes to make additional DNA that is used to copy the genome or be transcribed to messenger RNA (mRNA), which is then used in protein synthesis. RNA viruses, such as the influenza virus, usually use the RNA core as a template for synthesis of viral genomic RNA and mRNA. The viral mRNA is translated into viral enzymes and capsid proteins to assemble new virions (). Of course, there are exceptions to this pattern. If a host cell does not provide the enzymes necessary for viral replication, viral genes supply the information to direct synthesis of the missing proteins. Retroviruses, such as HIV, have an RNA genome that must be reverse transcribed to make DNA, which then is inserted into the host’s DNA. To convert RNA into DNA, retroviruses contain genes that encode the virus-specific enzyme reverse transcriptase that transcribes an RNA template to DNA. The fact that HIV produces some of its own enzymes, which are not found in the host, has allowed researchers to develop drugs that inhibit these enzymes. These drugs, including the reverse transcriptase inhibitor AZT, inhibit HIV replication by reducing the activity of the enzyme without affecting the host’s metabolism.The last stage of viral replication is the release of the new virions into the host organism, where they are able to infect adjacent cells and repeat the replication cycle. Some viruses are released when the host cell dies and other viruses can leave infected cells by budding through the membrane without directly killing the cell.
@@ -72,7 +72,7 @@
- Click through this tutorial on viruses to identify structures, modes of transmission, replication, and more.
+ Click through this tutorial on viruses to identify structures, modes of transmission, replication, and more.Viruses and Disease
diff --git a/modules/m45543/index.cnxml b/modules/m45543/index.cnxml
index 254395c46..1e514a55c 100644
--- a/modules/m45543/index.cnxml
+++ b/modules/m45543/index.cnxml
@@ -48,7 +48,7 @@
An antigen-presenting cell (APC), such as a macrophage, engulfs a foreign antigen, partially digests it in a lysosome, and then embeds it in an MHC class II molecule for presentation at the cell surface. Lymphocytes of the adaptive immune response must interact with antigen-embedded MHC class II molecules to mature into functional immune cells.
- View this animation from Rockefeller University to see how dendritic cells act as sentinels in the body’s immune system.
+ View this animation from Rockefeller University to see how dendritic cells act as sentinels in the body’s immune system.T cells have many functions. Some respond to APCs of the innate immune system and indirectly induce immune responses by releasing cytokines. Others stimulate B cells to start the humoral response as described previously. Another type of T cell detects APC signals and directly kills the infected cells, while some are involved in suppressing inappropriate immune reactions to harmless or “self” antigens.There are two main types of T cells: helper T lymphocytes (TH) and the cytotoxic T lymphocytes (TC). The TH lymphocytes function indirectly to tell other immune cells about potential pathogens. TH lymphocytes recognize specific antigens presented by the MHC class II complexes of APCs. There are two populations of TH cells: TH1 and TH2. TH1 cells secrete cytokines to enhance the activities of macrophages and other T cells. TH2 cells stimulate naïve B cells to secrete antibodies. Whether a TH1 or a TH2 immune response develops depends on the specific types of cytokines secreted by cells of the innate immune system, which in turn depends on the nature of the invading pathogen.Cytotoxic T cells (TC) are the key component of the cell-mediated part of the adaptive immune system and attack and destroy infected cells. TC cells are particularly important in protecting against viral infections; this is because viruses replicate within cells where they are shielded from extracellular contact with circulating antibodies. Once activated, the TC creates a large clone of cells with one specific set of cell-surface receptors, as in the case with proliferation of activated B cells. As with B cells, the clone includes active TC cells and inactive memory TC cells. The resulting active TC cells then identify infected host cells. Because of the time required to generate a population of clonal T and B cells, there is a delay in the adaptive immune response compared to the innate immune response.
diff --git a/modules/m45545/index.cnxml b/modules/m45545/index.cnxml
index b40a83c61..e5d02b8b9 100644
--- a/modules/m45545/index.cnxml
+++ b/modules/m45545/index.cnxml
@@ -34,7 +34,7 @@
On first exposure to an allergen, an antibody is synthesized by plasma cells in response to a harmless antigen. The antibodies bind to mast cells, and on secondary exposure, the mast cells release histamines and other modulators that cause the symptoms of allergy. (credit: modification of work by NIH)
Delayed hypersensitivity is a cell-mediated immune response that takes approximately one to two days after secondary exposure for a maximal reaction. This type of hypersensitivity involves the TH1 cytokine-mediated inflammatory response and may cause local tissue lesions or contact dermatitis (rash or skin irritation). Delayed hypersensitivity occurs in some individuals in response to contact with certain types of jewelry or cosmetics. Delayed hypersensitivity facilitates the immune response to poison ivy and is also the reason why the skin test for tuberculosis results in a small region of inflammation on individuals who were previously exposed to Mycobacterium tuberculosis, the organism that causes tuberculosis.
- Try your hand at diagnosing an allergic reaction by selecting one of the interactive case studies at the World Allergy Organization website.
+ Try your hand at diagnosing an allergic reaction by selecting one of the interactive case studies at the World Allergy Organization website.Autoimmunity
diff --git a/modules/m45547/index.cnxml b/modules/m45547/index.cnxml
index 467d96beb..8fa07a8fc 100644
--- a/modules/m45547/index.cnxml
+++ b/modules/m45547/index.cnxml
@@ -35,7 +35,7 @@
(a) Hydra reproduce asexually through budding: a bud forms on the tubular body of an adult hydra, develops a mouth and tentacles, and then detaches from its parent. The new hydra is fully developed and will find its own location for attachment. (b) Some coral, such as the Lophelia pertusa shown here, can reproduce through budding. (credit b: modification of work by Ed Bowlby, NOAA/Olympic Coast NMS; NOAA/OAR/Office of Ocean Exploration)
- View this video to see a hydra budding.
+ View this video to see a hydra budding.Fragmentation
diff --git a/modules/m45549/index.cnxml b/modules/m45549/index.cnxml
index 17ea4b955..3dafbe6ff 100644
--- a/modules/m45549/index.cnxml
+++ b/modules/m45549/index.cnxml
@@ -186,7 +186,7 @@
During spermatogenesis, four sperm result from each primary spermatocyte. The process also maps onto the physical structure of the wall of the seminiferous tubule, with the spermatogonia on the outer side of the tubule, and the sperm with their developing tails extended into the lumen of the tubule.
- Visit this site to see the process of spermatogenesis.
+ Visit this site to see the process of spermatogenesis.Oogenesis
@@ -251,7 +251,7 @@
(a) Fetal development is shown at nine weeks gestation. (b) This fetus is just entering the second trimester, when the placenta takes over more of the functions performed as the baby develops. (c) There is rapid fetal growth during the third trimester. (credit a: modification of work by Ed Uthman; credit b: modification of work by National Museum of Health and Medicine; credit c: modification of work by Gray’s Anatomy)
During the second trimester, the fetus grows to about 30 cm (about 12 inches) (b). It becomes active and the pregnant person usually feels the first movements. All organs and structures continue to develop. The placenta has taken over the functions of nutrition and waste elimination and the production of estrogen and progesterone from the corpus luteum, which has degenerated. The placenta will continue functioning up through the delivery of the baby. During the third trimester, the fetus grows to 3 to 4 kg (6.5–8.5 lbs.) and about 50 cm (19–20 inches) long (c). This is the period of the most rapid growth during the pregnancy as all organ systems continue to grow and develop.
- Visit this website to see the stages of human fetal development.Labor is the muscular contractions to expel the fetus and placenta from the uterus. Toward the end of the third trimester, estrogen causes receptors on the uterine wall to develop and bind the hormone oxytocin. At this time, the baby reorients, facing forward and down with the back or crown of the head engaging the cervix (uterine opening). This causes the cervix to stretch and nerve impulses are sent to the hypothalamus, which signals the release of oxytocin from the posterior pituitary. Oxytocin causes smooth muscle in the uterine wall to contract. At the same time, the placenta releases prostaglandins into the uterus, increasing the contractions. A positive feedback relay occurs between the uterus, hypothalamus, and the posterior pituitary to assure an adequate supply of oxytocin. As more smooth muscle cells are recruited, the contractions increase in intensity and force.
+ Visit this website to see the stages of human fetal development.Labor is the muscular contractions to expel the fetus and placenta from the uterus. Toward the end of the third trimester, estrogen causes receptors on the uterine wall to develop and bind the hormone oxytocin. At this time, the baby reorients, facing forward and down with the back or crown of the head engaging the cervix (uterine opening). This causes the cervix to stretch and nerve impulses are sent to the hypothalamus, which signals the release of oxytocin from the posterior pituitary. Oxytocin causes smooth muscle in the uterine wall to contract. At the same time, the placenta releases prostaglandins into the uterus, increasing the contractions. A positive feedback relay occurs between the uterus, hypothalamus, and the posterior pituitary to assure an adequate supply of oxytocin. As more smooth muscle cells are recruited, the contractions increase in intensity and force.There are three stages to labor. During stage one, the cervix thins and dilates. This is necessary for the baby and placenta to be expelled during birth. The cervix will eventually dilate to about 10 cm. During stage two, the baby is expelled from the uterus. The uterus contracts and, in most cases, the person giving birth pushes as they compress the abdominal muscles to aid the delivery. The last stage is the passage of the placenta after the baby has been born and the organ has completely disengaged from the uterine wall. If labor should stop before stage two is reached, synthetic oxytocin, known as Pitocin, can be administered to restart and maintain labor.
diff --git a/modules/m45550/index.cnxml b/modules/m45550/index.cnxml
index b40658fbc..d827f5728 100644
--- a/modules/m45550/index.cnxml
+++ b/modules/m45550/index.cnxml
@@ -29,7 +29,7 @@
(a) During cleavage, the zygote rapidly divides into multiple cells. (b) The cells rearrange themselves to form a hollow ball called the blastula. (credit a: modification of work by Gray's Anatomy; credit b: modification of work by Pearson Scott Foresman; donated to the Wikimedia Foundation)
In mammals, the blastula forms the blastocyst in the next stage of development. Here the cells in the blastula arrange themselves in two layers: the inner cell mass, and an outer layer called the trophoblast. The inner cell mass will go on to form the embryo. The trophoblast secretes enzymes that allow implantation of the blastocyst into the endometrium of the uterus. The trophoblast will contribute to the placenta and nourish the embryo.
- Visit the Virtual Human Embryo project at the Endowment for Human Development site to click through an interactive of the stages of embryo development, including micrographs and rotating 3-D images.
+ Visit the Virtual Human Embryo project at the Endowment for Human Development site to click through an interactive of the stages of embryo development, including micrographs and rotating 3-D images.The cells in the blastula then rearrange themselves spatially to form three layers of cells. This process is called gastrulation. During gastrulation, the blastula folds in on itself and cells migrate to form the three layers of cells () in a structure, the gastrula, with a hollow space that will become the digestive tract. Each of the layers of cells is called a germ layer and will differentiate into different organ systems.
diff --git a/modules/m45554/index.cnxml b/modules/m45554/index.cnxml
index 06763d6e3..f0b84d482 100644
--- a/modules/m45554/index.cnxml
+++ b/modules/m45554/index.cnxml
@@ -27,7 +27,7 @@
The time between the addition of each billion human beings to Earth decreases over time. (credit: modification of work by Ryan T. Cragun)
-Click through this video of how human populations have changed over time.
+Click through this video of how human populations have changed over time.Overcoming Density-Dependent RegulationHumans are unique in their ability to alter their environment in myriad ways. This ability is responsible for human population growth because it resets the carrying capacity and overcomes density-dependent growth regulation. Much of this ability is related to human intelligence, society, and communication. Humans construct shelters to protect themselves from the elements and have developed agriculture and domesticated animals to increase their food supplies. In addition, humans use language to communicate this technology to new generations, allowing them to improve upon previous accomplishments.Other factors in human population growth are migration and public health. Humans originated in Africa, but we have since migrated to nearly all inhabitable land on Earth, thus, increasing the area that we have colonized. Public health, sanitation, and the use of antibiotics and vaccines have decreased the ability of infectious disease to limit human population growth in developed countries. In the past, diseases such as the bubonic plaque of the fourteenth century killed between 30 and 60 percent of Europe’s population and reduced the overall world population by as many as one hundred million people. Infectious disease continues to have an impact on human population growth. For example, life expectancy in sub-Saharan Africa, which was increasing from 1950 to 1990, began to decline after 1985 largely as a result of HIV/AIDS mortality. The reduction in life expectancy caused by HIV/AIDS was estimated to be 7 years for 2005.Danny Dorling, Mary Shaw, and George Davey Smith, “Global Inequality of Life Expectancy due to AIDS,” BMJ 332, no. 7542 (March 2006): 662-664, doi: 10.1136/bmj.332.7542.662.
@@ -56,7 +56,7 @@
Another consequence of population growth is the change and degradation of the natural environment. Many countries have attempted to reduce the human impact on climate change by limiting their emission of greenhouse gases. However, a global climate change treaty remains elusive, and many underdeveloped countries trying to improve their economic condition may be less likely to agree with such provisions without compensation if it means slowing their economic development. Furthermore, the role of human activity in causing climate change has become a hotly debated socio-political issue in some developed countries, including the United States. Thus, we enter the future with considerable uncertainty about our ability to curb human population growth and protect our environment to maintain the carrying capacity for the human species.
-Visit this website and select “Launch the movie” for an animation discussing the global impacts of human population growth.
+Visit this website and select “Launch the movie” for an animation discussing the global impacts of human population growth.Section SummaryEarth’s human population is growing exponentially. Humans have increased their carrying capacity through technology, urbanization, and harnessing the energy of fossil fuels. The age structure of a population allows us to predict population growth. Unchecked human population growth could have dire long-term effects on human welfare and Earth’s ecosystems.
diff --git a/modules/m45555/index.cnxml b/modules/m45555/index.cnxml
index 35f262a95..a04c74dc7 100644
--- a/modules/m45555/index.cnxml
+++ b/modules/m45555/index.cnxml
@@ -45,7 +45,7 @@
Several unpleasant-tasting Heliconius butterfly species share a similar color pattern with better-tasting varieties, an example of mimicry. (credit: Joron M, Papa R, Beltrán M, Chamberlain N, Mavárez J, et al.)
-Go to this website to view stunning examples of mimicry.
+Go to this website to view stunning examples of mimicry.
@@ -80,7 +80,7 @@
This diagram shows the life cycle of the tapeworm, a human worm parasite. (credit: modification of work by CDC)
-To learn more about “Symbiosis in the Sea,” watch this webisode of Jonathan Bird’s Blue World.
+To learn more about “Symbiosis in the Sea,” watch this webisode of Jonathan Bird’s Blue World.Characteristics of Communities
diff --git a/modules/m45558/index.cnxml b/modules/m45558/index.cnxml
index 59bd76bad..cdd77b106 100644
--- a/modules/m45558/index.cnxml
+++ b/modules/m45558/index.cnxml
@@ -65,7 +65,7 @@
-Head to this online interactive simulator to investigate food web function. In the Interactive Labs box, under Food Web, click Step 1. Read the instructions first, and then click Step 2 for additional instructions. When you are ready to create a simulation, in the upper-right corner of the Interactive Labs box, click OPEN SIMULATOR.Two general types of food webs are often shown interacting within a single ecosystem. A grazing food web has plants or other photosynthetic organisms at its base, followed by herbivores and various carnivores. A detrital food web consists of a base of organisms that feed on decaying organic matter (dead organisms), including decomposers (which break down dead and decaying organisms) and detritivores (which consume organic detritus). These organisms are usually bacteria, fungi, and invertebrate animals that recycle organic material back into the biotic part of the ecosystem as they themselves are consumed by other organisms. As ecosystems require a method to recycle material from dead organisms, grazing food webs have an associated detrital food web. For example, in a meadow ecosystem, plants may support a grazing food web of different organisms, primary and other levels of consumers, while at the same time supporting a detrital food web of bacteria and fungi feeding off dead plants and animals. Simultaneously, a detrital food web can contribute energy to a grazing food web, as when a robin eats an earthworm.
+Head to this online interactive simulator to investigate food web function. In the Interactive Labs box, under Food Web, click Step 1. Read the instructions first, and then click Step 2 for additional instructions. When you are ready to create a simulation, in the upper-right corner of the Interactive Labs box, click OPEN SIMULATOR.Two general types of food webs are often shown interacting within a single ecosystem. A grazing food web has plants or other photosynthetic organisms at its base, followed by herbivores and various carnivores. A detrital food web consists of a base of organisms that feed on decaying organic matter (dead organisms), including decomposers (which break down dead and decaying organisms) and detritivores (which consume organic detritus). These organisms are usually bacteria, fungi, and invertebrate animals that recycle organic material back into the biotic part of the ecosystem as they themselves are consumed by other organisms. As ecosystems require a method to recycle material from dead organisms, grazing food webs have an associated detrital food web. For example, in a meadow ecosystem, plants may support a grazing food web of different organisms, primary and other levels of consumers, while at the same time supporting a detrital food web of bacteria and fungi feeding off dead plants and animals. Simultaneously, a detrital food web can contribute energy to a grazing food web, as when a robin eats an earthworm.How Organisms Acquire Energy in a Food Web
diff --git a/modules/m45559/index.cnxml b/modules/m45559/index.cnxml
index 4cc14acb0..0e8b3f021 100644
--- a/modules/m45559/index.cnxml
+++ b/modules/m45559/index.cnxml
@@ -18,7 +18,7 @@
The cycling of these elements is interconnected. For example, the movement of water is critical for the leaching of nitrogen and phosphate into rivers, lakes, and oceans. The ocean is also a major reservoir for carbon. Thus, mineral nutrients are cycled, either rapidly or slowly, through the entire biosphere between the biotic and abiotic world and from one living organism to another.
-Head to this website to learn more about biogeochemical cycles.
+Head to this website to learn more about biogeochemical cycles.The Water CycleWater is essential for all living processes. The human body is more than one-half water and human cells are more than 70 percent water. Thus, most land animals need a supply of fresh water to survive. Of the stores of water on Earth, 97.5 percent is salt water (). Of the remaining water, 99 percent is locked as underground water or ice. Thus, less than one percent of fresh water is present in lakes and rivers. Many living things are dependent on this small amount of surface fresh water supply, a lack of which can have important effects on ecosystem dynamics. Humans, of course, have developed technologies to increase water availability, such as digging wells to harvest groundwater, storing rainwater, and using desalination to obtain drinkable water from the ocean. Although this pursuit of drinkable water has been ongoing throughout human history, the supply of fresh water continues to be a major issue in modern times.
diff --git a/modules/m45560/index.cnxml b/modules/m45560/index.cnxml
index 41f935497..88c99dea0 100644
--- a/modules/m45560/index.cnxml
+++ b/modules/m45560/index.cnxml
@@ -112,7 +112,7 @@
-Watch this Assignment Discovery: Biomes video for an overview of biomes. To explore further, select one of the biomes on the extended playlist: desert, savanna, temperate forest, temperate grassland, tropic, tundra.
+Watch this Assignment Discovery: Biomes video for an overview of biomes. To explore further, select one of the biomes on the extended playlist: desert, savanna, temperate forest, temperate grassland, tropic, tundra.Section SummaryEarth has terrestrial and aquatic biomes. Aquatic biomes include both freshwater and marine environments. There are eight major terrestrial biomes: tropical rainforests, savannas, subtropical deserts, chaparral, temperate grasslands, temperate forests, boreal forests, and Arctic tundra. The same biome can occur in different geographic locations with similar climates. Temperature and precipitation, and variations in both, are key abiotic factors that shape the composition of animal and plant communities in terrestrial biomes. Some biomes, such as temperate grasslands and temperate forests, have distinct seasons with cold and hot weather alternating throughout the year. In warm, moist biomes, such as the tropical rainforest, net primary productivity is high as warm temperatures, abundant water, and a year-round growing season fuel plant growth. Other biomes, such as deserts and tundra, have low primary productivity due to extreme temperatures and a shortage of water.
diff --git a/modules/m45562/index.cnxml b/modules/m45562/index.cnxml
index 153fc85eb..7ef94643f 100644
--- a/modules/m45562/index.cnxml
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@@ -54,7 +54,7 @@
Coral reefs are ocean ridges formed by marine invertebrates living in warm shallow waters within the photic zone of the ocean. They are found within 30˚ north and south of the equator. The Great Barrier Reef is a well-known reef system located several miles off the northeastern coast of Australia. Other coral reefs are fringing islands, which are directly adjacent to land, or atolls, which are circular reefs surrounding a former island that is now underwater. The coral-forming colonies of organisms (members of phylum Cnidaria) secrete a calcium carbonate skeleton. These calcium-rich skeletons slowly accumulate, thus forming the underwater reef (). Corals found in shallower waters (at a depth of approximately 60 m or about 200 ft) have a mutualistic relationship with photosynthetic unicellular protists. The relationship provides corals with the majority of the nutrition and the energy they require. The waters in which these corals live are nutritionally poor and, without this mutualism, it would not be possible for large corals to grow because there are few planktonic organisms for them to feed on. Some corals living in deeper and colder water do not have a mutualistic relationship with protists; these corals must obtain their energy exclusively by feeding on plankton using stinging cells on their tentacles.
-In this National Oceanic and Atmospheric Administration (NOAA) video, marine ecologist Dr. Peter Etnoyer discusses his research on coral organisms.Coral reefs are one of the most diverse biomes. It is estimated that more than 4000 fish species inhabit coral reefs. These fishes can feed on coral, the cryptofauna (invertebrates found within the calcium carbonate structures of the coral reefs), or the seaweed and algae that are associated with the coral. These species include predators, herbivores, or planktivores. Predators are animal species that hunt and are carnivores or “flesh eaters.” Herbivores eat plant material, and planktivores eat plankton.
+In this National Oceanic and Atmospheric Administration (NOAA) video, marine ecologist Dr. Peter Etnoyer discusses his research on coral organisms.Coral reefs are one of the most diverse biomes. It is estimated that more than 4000 fish species inhabit coral reefs. These fishes can feed on coral, the cryptofauna (invertebrates found within the calcium carbonate structures of the coral reefs), or the seaweed and algae that are associated with the coral. These species include predators, herbivores, or planktivores. Predators are animal species that hunt and are carnivores or “flesh eaters.” Herbivores eat plant material, and planktivores eat plankton.
diff --git a/modules/m45571/index.cnxml b/modules/m45571/index.cnxml
index 00fe9b018..73126f0e2 100644
--- a/modules/m45571/index.cnxml
+++ b/modules/m45571/index.cnxml
@@ -181,7 +181,7 @@ Biogeography is the study of the distribution of the world’s species both in t
Fishery extinctions rarely lead to complete extinction of the harvested species, but rather to a radical restructuring of the marine ecosystem in which a dominant species is so over-harvested that it becomes a minor player, ecologically. In addition to humans losing the food source, these alterations affect many other species in ways that are difficult or impossible to predict. The collapse of fisheries has dramatic and long-lasting effects on local human populations that work in the fishery. In addition, the loss of an inexpensive protein source to populations that cannot afford to replace it will increase the cost of living and limit societies in other ways. In general, the fish taken from fisheries have shifted to smaller species and the larger species are overfished. The ultimate outcome could clearly be the loss of aquatic systems as food sources.
-Visit this website to view a brief video discussing a study of declining fisheries.
+Visit this website to view a brief video discussing a study of declining fisheries.Section SummaryBiodiversity exists at multiple levels of organization, and is measured in different ways depending on the goals of those taking the measurements. These include numbers of species, genetic diversity, chemical diversity, and ecosystem diversity. The number of described species is estimated to be 1.5 million with about 17,000 new species being described each year. Estimates for the total number of eukaryotic species on Earth vary but are on the order of 10 million. Biodiversity is negatively correlated with latitude for most taxa, meaning that biodiversity is higher in the tropics. The mechanism for this pattern is not known with certainty, but several plausible hypotheses have been advanced.
diff --git a/modules/m45573/index.cnxml b/modules/m45573/index.cnxml
index 69582aaf0..ceb6367d2 100644
--- a/modules/m45573/index.cnxml
+++ b/modules/m45573/index.cnxml
@@ -44,7 +44,7 @@
A typical species-area curve shows the cumulative number of species found as more and more area is sampled. The curve has also been interpreted to show the effect on species numbers of destroying habitat; a reduction in habitat of 90 percent from 100 km2 to 10 km2 reduces the number of species supported by about 50 percent.
- Go to this website for an interactive exploration of endangered and extinct species, their ecosystems, and the causes of their endangerment or extinction.
+ Go to this website for an interactive exploration of endangered and extinct species, their ecosystems, and the causes of their endangerment or extinction.Conservation of BiodiversityThe threats to biodiversity at the genetic, species, and ecosystem levels have been recognized for some time. In the United States, the first national park with land set aside to remain in a wilderness state was Yellowstone Park in 1872. However, attempts to preserve nature for various reasons have occurred for centuries. Today, the main efforts to preserve biodiversity involve legislative approaches to regulate human and corporate behavior, setting aside protected areas, and habitat restoration.
@@ -72,7 +72,7 @@
Finally, an argument can be made that conservation preserves reinforce the cultural perception that humans are separate from nature, can exist outside of it, and can only operate in ways that do damage to biodiversity. Creating preserves reduces the pressure on human activities outside the preserves to be sustainable and non-damaging to biodiversity. Ultimately, the political, economic, and human demographic pressures will degrade and reduce the size of conservation preserves if the activities outside them are not altered to be less damaging to biodiversity.
- Check out this interactive global data system of protected areas. Review data about specific protected areas by location or study statistics on protected areas by country or region.
+ Check out this interactive global data system of protected areas. Review data about specific protected areas by location or study statistics on protected areas by country or region.Habitat RestorationHabitat restoration holds considerable promise as a mechanism for maintaining or restoring biodiversity. Of course once a species has become extinct, its restoration is impossible. However, restoration can improve the biodiversity of degraded ecosystems. Reintroducing wolves, a top predator, to Yellowstone National Park in 1995 led to dramatic changes in the ecosystem that increased biodiversity. The wolves () function to suppress elk and coyote populations and provide more abundant resources to the guild of carrion eaters. Reducing elk populations has allowed revegetation of riparian (the areas along the banks of a stream or river) areas, which has increased the diversity of species in that habitat. Suppression of coyotes has increased the species previously suppressed by this predator. The number of species of carrion eaters has increased because of the predatory activities of the wolves. In this habitat, the wolf is a keystone species, meaning a species that is instrumental in maintaining diversity within an ecosystem. Removing a keystone species from an ecological community causes a collapse in diversity. The results from the Yellowstone experiment suggest that restoring a keystone species effectively can have the effect of restoring biodiversity in the community. Ecologists have argued for the identification of keystone species where possible and for focusing protection efforts on these species. It makes sense to return the keystone species to the ecosystems where they have been removed.
diff --git a/modules/m45574/index.cnxml b/modules/m45574/index.cnxml
index 6cafe4550..9e93041b2 100644
--- a/modules/m45574/index.cnxml
+++ b/modules/m45574/index.cnxml
@@ -33,16 +33,16 @@ Most consumers do not imagine that the home improvement products they buy might
Habitat destruction can affect ecosystems other than forests. Rivers and streams are important ecosystems and are frequently the target of habitat modification through building and from damming or water removal. Damming of rivers affects flows and access to all parts of a river. Altering a flow regime can reduce or eliminate populations that are adapted to seasonal changes in flow. For example, an estimated 91 percent of river lengths in the United States have been modified with damming or bank modifications. Many fish species in the United States, especially rare species or species with restricted distributions, have seen declines caused by river damming and habitat loss. Research has confirmed that species of amphibians that must carry out parts of their life cycles in both aquatic and terrestrial habitats are at greater risk of population declines and extinction because of the increased likelihood that one of their habitats or access between them will be lost. This is of particular concern because amphibians have been declining in numbers and going extinct more rapidly than many other groups for a variety of possible reasons. Habitat destruction, even when undertaken on behalf of humans, can lead to negative effects for us as well. Excessive soil erosion after forest removal, for example, can remove fertile soil and make river water toxic. Scientists and conservationists such as Wangari Maathai, who founded the Green Belt movement in Kenya, focus on replanting trees to repair habitats and prevent damage from deforestation. Maathai was awarded a Nobel Prize for her work, but unfortunately passed away in 2011.OverharvestingOverharvesting is a serious threat to many species, but particularly to aquatic species. There are many examples of regulated fisheries (including hunting of marine mammals and harvesting of crustaceans and other species) monitored by fisheries scientists that have nevertheless collapsed. The western Atlantic cod fishery is the most spectacular recent collapse. While it was a hugely productive fishery for 400 years, the introduction of modern factory trawlers in the 1980s and the pressure on the fishery led to it becoming unsustainable. The causes of fishery collapse are both economic and political in nature. Most fisheries are managed as a common resource, available to anyone willing to fish, even when the fishing territory lies within a country’s territorial waters. Common resources are subject to an economic pressure known as the tragedy of the commons, in which fishers have little motivation to exercise restraint in harvesting a fishery when they do not own the fishery. The general outcome of harvests of resources held in common is their overexploitation. While large fisheries are regulated to attempt to avoid this pressure, it still exists in the background. This overexploitation is exacerbated when access to the fishery is open and unregulated and when technology gives fishers the ability to overfish. In a few fisheries, the biological growth of the resource is less than the potential growth of the profits made from fishing if that time and money were invested elsewhere. In these cases—whales are an example—economic forces will drive toward fishing the population to extinction.
- Explore a U.S. Fish & Wildlife Service interactive map of critical habitat for endangered and threatened species in the United States. To begin, select “Visit the online mapper.”For the most part, fishery extinction is not equivalent to biological extinction—the last fish of a species is rarely fished out of the ocean. But there are some instances in which true extinction is a possibility. Whales have slow-growing populations and are at risk of complete extinction through hunting. Also, there are some species of sharks with restricted distributions that are at risk of extinction. The groupers are another population of generally slow-growing fishes that, in the Caribbean, includes a number of species that are at risk of extinction from overfishing.
+ Explore a U.S. Fish & Wildlife Service interactive map of critical habitat for endangered and threatened species in the United States. To begin, select “Visit the online mapper.”For the most part, fishery extinction is not equivalent to biological extinction—the last fish of a species is rarely fished out of the ocean. But there are some instances in which true extinction is a possibility. Whales have slow-growing populations and are at risk of complete extinction through hunting. Also, there are some species of sharks with restricted distributions that are at risk of extinction. The groupers are another population of generally slow-growing fishes that, in the Caribbean, includes a number of species that are at risk of extinction from overfishing.Coral reefs are extremely diverse marine ecosystems that face peril from several processes. Reefs are home to 1/3 of the world’s marine fish species—about 4000 species—despite making up only one percent of marine habitat. Most home marine aquaria house coral reef species that are wild-caught organisms—not cultured organisms. Although no marine species is known to have been driven extinct by the pet trade, there are studies showing that populations of some species have declined in response to harvesting, indicating that the harvest is not sustainable at those levels. There are also concerns about the effect of the pet trade on some terrestrial species such as turtles, amphibians, birds, plants, and even the orangutans.
- View a brief video discussing the role of marine ecosystems in supporting human welfare and the decline of ocean ecosystems.Bush meat is the generic term used for wild animals killed for food. Hunting is practiced throughout the world, but hunting practices, particularly in equatorial Africa and parts of Asia, are believed to threaten several species with extinction. Traditionally, bush meat in Africa was hunted to feed families directly; however, recent commercialization of the practice now has bush meat available in grocery stores, which has increased harvest rates to the level of unsustainability. Additionally, human population growth has increased the need for protein foods that are not being met from agriculture. Species threatened by the bush meat trade are mostly mammals including many monkeys and the great apes living in the Congo basin.
+ View a brief video discussing the role of marine ecosystems in supporting human welfare and the decline of ocean ecosystems.Bush meat is the generic term used for wild animals killed for food. Hunting is practiced throughout the world, but hunting practices, particularly in equatorial Africa and parts of Asia, are believed to threaten several species with extinction. Traditionally, bush meat in Africa was hunted to feed families directly; however, recent commercialization of the practice now has bush meat available in grocery stores, which has increased harvest rates to the level of unsustainability. Additionally, human population growth has increased the need for protein foods that are not being met from agriculture. Species threatened by the bush meat trade are mostly mammals including many monkeys and the great apes living in the Congo basin.Exotic SpeciesExotic species are species that have been intentionally or unintentionally introduced by humans into an ecosystem in which they did not evolve. Human transportation of people and goods, including the intentional transport of organisms for trade, has dramatically increased the introduction of species into new ecosystems. These new introductions are sometimes at distances that are well beyond the capacity of the species to ever travel itself and outside the range of the species’ natural predators.Most exotic species introductions probably fail because of the low number of individuals introduced or poor adaptation to the ecosystem they enter. Some species, however, have characteristics that can make them especially successful in a new ecosystem. These exotic species often undergo dramatic population increases in their new habitat and reset the ecological conditions in the new environment, threatening the species that exist there. When this happens, the exotic species also becomes an invasive species. Invasive species can threaten other species through competition for resources, predation, or disease.
- Explore this interactive global database of exotic or invasive species.
+ Explore this interactive global database of exotic or invasive species.Lakes and islands are particularly vulnerable to extinction threats from introduced species. In Lake Victoria, the intentional introduction of the Nile perch was largely responsible for the extinction of about 200 species of cichlids. The accidental introduction of the brown tree snake via aircraft () from the Solomon Islands to Guam in 1950 has led to the extinction of three species of birds and three to five species of reptiles endemic to the island. Several other species are still threatened. The brown tree snake is adept at exploiting human transportation as a means to migrate; one was even found on an aircraft arriving in Corpus Christi, Texas. Constant vigilance on the part of airport, military, and commercial aircraft personnel is required to prevent the snake from moving from Guam to other islands in the Pacific, especially Hawaii. Islands do not make up a large area of land on the globe, but they do contain a disproportionate number of endemic species because of their isolation from mainland ancestors.
diff --git a/modules/m62716/index.cnxml b/modules/m62716/index.cnxml
index 2a05b44bc..15b8e5571 100644
--- a/modules/m62716/index.cnxml
+++ b/modules/m62716/index.cnxml
@@ -15,12 +15,12 @@
This NASA image is a composite of several satellite-based views of Earth. To make the whole-Earth image, NASA scientists combine observations of different parts of the planet. (credit: NASA/GSFC/NOAA/USGS)
-Viewed from space, Earth offers no clues about the diversity of life it harbors. The first forms of life on Earth are thought to be microorganisms that existed for billions of years in the ocean before plants and animals appeared. The mammals, birds, and flowers that we see in modern times are mostly “recent” species, originating 130 to 200 million years ago. In fact, only in the last 300,000 years have humans started looking like we do today.Organisms evolve in response to each other. One of the best examples is disease causing organisms, which have to adapt to overcome the defenses of the organisms they infect. One such organism that has evolved to specialize in infection in humans is Plasmodium, the organism that causes malaria. Biologists use the process of science to learn about the world and the organisms living in it. For example, people have suspected for quite some time that people with blood type O are less likely to die from severe malaria. Now, a team of scientists have been able to explain why. By examining data from several experiments, and by using both inductive and deductive reasoning, the scientists concluded that A and B type blood reacts with a protein excreted by Plasmodium. This reaction causes severe illness. However, type O blood does not react with the protein. You can read more about the response of type A and B blood groups to infection by Plasmodium.
+Viewed from space, Earth offers no clues about the diversity of life it harbors. The first forms of life on Earth are thought to be microorganisms that existed for billions of years in the ocean before plants and animals appeared. The mammals, birds, and flowers that we see in modern times are mostly “recent” species, originating 130 to 200 million years ago. In fact, only in the last 300,000 years have humans started looking like we do today.Organisms evolve in response to each other. One of the best examples is disease causing organisms, which have to adapt to overcome the defenses of the organisms they infect. One such organism that has evolved to specialize in infection in humans is Plasmodium, the organism that causes malaria. Biologists use the process of science to learn about the world and the organisms living in it. For example, people have suspected for quite some time that people with blood type O are less likely to die from severe malaria. Now, a team of scientists have been able to explain why. By examining data from several experiments, and by using both inductive and deductive reasoning, the scientists concluded that A and B type blood reacts with a protein excreted by Plasmodium. This reaction causes severe illness. However, type O blood does not react with the protein. You can read more about the response of type A and B blood groups to infection by Plasmodium.
Introduce the concept of unity and diversity of life. There are so many varieties of organisms and, yet, the cell is the basic unit of life. The fundamental structures and life processes of cells are similar; but, how these cells are utilized in different organisms is hugely varied and reflects adaptation of the organism to its environment. The many differences between species accumulated over long periods of time. Students are often unfamiliar with geological time scales.
-The malaria example was chosen because malaria has been one of the most pervasive and widespread human disease. Therefore, through much of human history, malaria has been a strong force of natural selection on humans. Human genetics has evolved in response to this selection pressure, as with the example of resistance among O-type blood groups described in the introduction. Further examples can also be found here.
+The malaria example was chosen because malaria has been one of the most pervasive and widespread human disease. Therefore, through much of human history, malaria has been a strong force of natural selection on humans. Human genetics has evolved in response to this selection pressure, as with the example of resistance among O-type blood groups described in the introduction. Further examples can also be found here.
diff --git a/modules/m62717/index.cnxml b/modules/m62717/index.cnxml
index 9c1c3c817..b095de1de 100644
--- a/modules/m62717/index.cnxml
+++ b/modules/m62717/index.cnxml
@@ -63,7 +63,7 @@
Biology is not a collection of facts to be memorized. Biological systems follow the law of physics and chemistry. Give as an example gas laws in chemistry and respiration physiology. Many students come with a 19th century view of natural sciences; each discipline is in its own sphere. Give as an example, bioinformatics which uses organism biology, chemistry, and physics to label DNA with light emitting reporter molecules (Next Generation sequencing). These molecules can then be scanned by light-sensing machinery, allowing huge amounts of information to be gathered on their DNA. Bring to their attention the fact that the analysis of these data is an application of mathematics and computer science.
-For more information about next generation sequencing, check out this informative review.
+For more information about next generation sequencing, check out this informative review.
@@ -143,7 +143,7 @@
Tell students a similar experiment on a grand scale may have happened in the past and introduce the next activity “What killed the dinosaurs?”Some predictions can be made and later observations can support or disprove the prediction.Ask, “what killed the dinosaurs?” Explain many scientists point to a massive asteroid crashing in the Yucatan peninsula in Mexico. One of the effects was the creation of smoke clouds and debris that blocked the Sun, stamped out many plants and, consequently, brought mass extinction. As is common in the scientific community, many other researchers offer divergent explanations.
-Go to this site for a good example of the complexity of scientific method and scientific debate.
+Go to this site for a good example of the complexity of scientific method and scientific debate.
diff --git a/modules/m62718/index.cnxml b/modules/m62718/index.cnxml
index e529139a0..a84d53d1b 100644
--- a/modules/m62718/index.cnxml
+++ b/modules/m62718/index.cnxml
@@ -85,7 +85,7 @@
The leaves of this sensitive plant (Mimosa pudica) will instantly droop and fold when touched. After a few minutes, the plant returns to normal. (credit: Alex Lomas)
Organisms respond to diverse stimuli. For example, plants can bend toward a source of light, climb on fences and walls, or respond to touch (). Even tiny bacteria can move toward or away from chemicals (a process called chemotaxis) or light (phototaxis). Movement toward a stimulus is considered a positive response, while movement away from a stimulus is considered a negative response.
- Watch this video to see how plants respond to a stimulus—from opening to light, to wrapping a tendril around a branch, to capturing prey.
+ Watch this video to see how plants respond to a stimulus—from opening to light, to wrapping a tendril around a branch, to capturing prey.
@@ -171,7 +171,7 @@ The diversity of life on Earth is a result of mutations, or random changes in he
All molecules, including this DNA molecule, are composed of atoms. (credit: “brian0918”/Wikimedia Commons)
-Watch this video that animates the three-dimensional structure of the DNA molecule shown in this figure.
+Watch this video that animates the three-dimensional structure of the DNA molecule shown in this figure.
@@ -249,7 +249,7 @@ The diversity of life on Earth is a result of mutations, or random changes in he
Once bats were called flying mice. According to the tree, is this a valid characterization?AnswerNo, bats are more closely related to shrew and moles.Ask students the question, how did reptiles learn how to fly?
-For an exploration of the evolution of flight visit this site.
+For an exploration of the evolution of flight visit this site.Birds are not modern day dinosaurs. Birds evolved from dinosaurs. Many changes took place over time.
diff --git a/modules/m62719/index.cnxml b/modules/m62719/index.cnxml
index 431c4dc25..49f3375b0 100644
--- a/modules/m62719/index.cnxml
+++ b/modules/m62719/index.cnxml
@@ -13,7 +13,7 @@
Atoms are the building blocks of molecules found in the universe—air, soil, water, rocks . . . and also the cells of all living organisms. In this model of an organic molecule, the atoms of carbon (black), hydrogen (white), nitrogen (blue), oxygen (red), and phosphorus (yellow) are shown in proportional atomic size. The silver rods indicate chemical bonds. (credit: modification of work by Christian Guthier)
All matter, including living things, is made up of various combinations of elements. Some of the most abundant elements in living organisms include carbon, hydrogen, nitrogen, oxygen, sulfur, and phosphorus. These elements form the major biological molecules—nucleic acids, proteins, carbohydrates, and lipids—that are the fundamental components of living matter. Biologists study these important molecules to understand their unique structures which determine their specialized functions.All biological processes follow the laws of physics and chemistry. Therefore, in order to understand how biological systems work, it is important to understand the underlying physics and chemistry. For example, the flow of blood within the circulatory system follows the laws of physics regulating the modes of fluid flow. Chemical laws dictate the breakdown of large, complex food molecules into smaller molecules as well as their conversion to energy stored in adenosine triphosphate (ATP). Polar molecules, the formation of hydrogen bonds, and the resulting properties of water are key to understanding living processes. Recognizing the properties of acids and bases is important to understand various biological processes such as digestion. Therefore, the fundamentals of physics and chemistry are the foundation for gaining insight into biological processes.
-An example of how understanding of chemical processes can give insight to a biological process is recent research on seasonal affective disorder (SAD). This form of depression affects up to 10% of the population in the fall and winter. Symptoms include a tendency to overeat, oversleep, lack of energy, and difficulty concentrating on tasks. Now scientists have found out that not only may SAD be caused by a deficiency in vitamin D, but that it is more common in individuals with darker skin pigmentation. You can read more about it here.
+An example of how understanding of chemical processes can give insight to a biological process is recent research on seasonal affective disorder (SAD). This form of depression affects up to 10% of the population in the fall and winter. Symptoms include a tendency to overeat, oversleep, lack of energy, and difficulty concentrating on tasks. Now scientists have found out that not only may SAD be caused by a deficiency in vitamin D, but that it is more common in individuals with darker skin pigmentation. You can read more about it here.
diff --git a/modules/m62720/index.cnxml b/modules/m62720/index.cnxml
index 305390892..18db1b83c 100644
--- a/modules/m62720/index.cnxml
+++ b/modules/m62720/index.cnxml
@@ -189,7 +189,7 @@ Carbon is normally present in the atmosphere in the form of gaseous compounds li
-To learn more about atoms, isotopes, and how to tell one isotope from another, visit this site and run the simulation.
+To learn more about atoms, isotopes, and how to tell one isotope from another, visit this site and run the simulation.
@@ -240,7 +240,7 @@ Carbon is normally present in the atmosphere in the form of gaseous compounds li
The second electron shell may contain eight electrons. This shell contains another spherical s orbital and three “dumbbell” shaped p orbitals, each of which can hold two electrons, as shown in . After the 1s orbital is filled, the second electron shell is filled, first filling its 2s orbital and then its three p orbitals. When filling the p orbitals, each takes a single electron; once each p orbital has an electron, a second may be added. Lithium (Li) contains three electrons that occupy the first and second shells. Two electrons fill the 1s orbital, and the third electron then fills the 2s orbital. Its electron configuration is 1s22s1. Neon (Ne), on the other hand, has a total of ten electrons: two are in its innermost 1s orbital and eight fill its second shell (two each in the 2s and three p orbitals); thus, it is an inert gas and energetically stable as a single atom that will rarely form a chemical bond with other atoms. Larger elements have additional orbitals, making up the third electron shell. While the concepts of electron shells and orbitals are closely related, orbitals provide a more accurate depiction of the electron configuration of an atom because the orbital model specifies the different shapes and special orientations of all the places that electrons may occupy.
-Watch this visual animation to see the spatial arrangement of the p and s orbitals.
+Watch this visual animation to see the spatial arrangement of the p and s orbitals.
@@ -413,7 +413,7 @@ Carbon is normally present in the atmosphere in the form of gaseous compounds li
Another way the octet rule can be satisfied is by the sharing of electrons between atoms to form covalent bonds. These bonds are stronger and much more common than ionic bonds in the molecules of living organisms. Covalent bonds are commonly found in carbon-based organic molecules, such as our DNA and proteins. Covalent bonds are also found in inorganic molecules like H2O, CO2, and O2. One, two, or three pairs of electrons may be shared, making single, double, and triple bonds, respectively. The more covalent bonds between two atoms, the stronger their connection. Thus, triple bonds are the strongest.The strength of different levels of covalent bonding is one of the main reasons living organisms have a difficult time in acquiring nitrogen for use in constructing their molecules, even though molecular nitrogen, N2, is the most abundant gas in the atmosphere. Molecular nitrogen consists of two nitrogen atoms triple bonded to each other and, as with all molecules, the sharing of these three pairs of electrons between the two nitrogen atoms allows for the filling of their outer electron shells, making the molecule more stable than the individual nitrogen atoms. This strong triple bond makes it difficult for living systems to break apart this nitrogen in order to use it as constituents of proteins and DNA.The formation of water molecules provides an example of covalent bonding. The hydrogen and oxygen atoms that combine to form water molecules are bound together by covalent bonds, as shown in . The electron from the hydrogen splits its time between the incomplete outer shell of the hydrogen atoms and the incomplete outer shell of the oxygen atoms. To completely fill the outer shell of oxygen, which has six electrons in its outer shell but which would be more stable with eight, two electrons (one from each hydrogen atom) are needed: hence the well-known formula H2O. The electrons are shared between the two elements to fill the outer shell of each, making both elements more stable.
- View this short video to see an animation of ionic and covalent bonding.
+ View this short video to see an animation of ionic and covalent bonding.
diff --git a/modules/m62721/index.cnxml b/modules/m62721/index.cnxml
index 3d8664773..36f7a0bb6 100644
--- a/modules/m62721/index.cnxml
+++ b/modules/m62721/index.cnxml
@@ -53,7 +53,7 @@
-Discuss with students why scientists use the criteria of the presence of liquid water to determine if an environment or planet can support life. More information on this topic is available at this site.
+Discuss with students why scientists use the criteria of the presence of liquid water to determine if an environment or planet can support life. More information on this topic is available at this site.Have students create visual representations with annotations to explain how water’s molecular structure and the resulting polarity results in its unique properties. Have the students describe how these properties are vital to life processes.
@@ -81,7 +81,7 @@
Hydrogen bonding makes ice less dense than liquid water. The (a) lattice structure of ice makes it less dense than the freely flowing molecules of liquid water, enabling it to (b) float on water. (credit a: modification of work by Jane Whitney, image created using Visual Molecular Dynamics (VMD) softwareW. Humphrey W., A. Dalke, and K. Schulten, “VMD—Visual Molecular Dynamics,” Journal of Molecular Graphics 14 (1996): 33-38.; credit b: modification of work by Carlos Ponte)
-Click here to see a 3-D animation of the structure of an ice lattice.
+Click here to see a 3-D animation of the structure of an ice lattice.
@@ -148,7 +148,7 @@
The pH scale measures the concentration of hydrogen ions (H+) in a solution. (credit: modification of work by Edward Stevens)
-Watch this video for a straightforward explanation of pH and its logarithmic scale.
+Watch this video for a straightforward explanation of pH and its logarithmic scale.
@@ -165,7 +165,7 @@
This diagram shows the body’s buffering of blood pH levels. The blue arrows show the process of raising pH as more CO2 is made. The purple arrows indicate the reverse process: the lowering of pH as more bicarbonate is created.
Other examples of buffers are antacids used to combat excess stomach acid. Many of these over-the-counter medications work in the same way as blood buffers, usually with at least one ion capable of absorbing hydrogen and moderating pH, bringing relief to those that suffer “heartburn” after eating. The unique properties of water that contribute to this capacity to balance pH—as well as water’s other characteristics—are essential to sustaining life on Earth.
- To learn more about water. Visit the U.S. Geological Survey Water Science for Schools All About Water! website.
+ To learn more about water. Visit the U.S. Geological Survey Water Science for Schools All About Water! website.
diff --git a/modules/m62722/index.cnxml b/modules/m62722/index.cnxml
index 378cb6fe8..912ed8a73 100644
--- a/modules/m62722/index.cnxml
+++ b/modules/m62722/index.cnxml
@@ -57,7 +57,7 @@
-As a class, discuss how important carbon is in life forms. Include in the discussion how proteins, DNA, carbohydrates, biological molecules that distinguish life from inanimate materials, are composed of carbon. You can challenge students to consider a life form based on silicon instead of carbon, using this article as a catalyst.
+As a class, discuss how important carbon is in life forms. Include in the discussion how proteins, DNA, carbohydrates, biological molecules that distinguish life from inanimate materials, are composed of carbon. You can challenge students to consider a life form based on silicon instead of carbon, using this article as a catalyst.
diff --git a/modules/m62723/index.cnxml b/modules/m62723/index.cnxml
index e877a8cb8..52eda7a68 100644
--- a/modules/m62723/index.cnxml
+++ b/modules/m62723/index.cnxml
@@ -14,7 +14,7 @@
Foods such as bread, fruit, and cheese are rich sources of biological macromolecules. (credit: modification of work by Bengt Nyman)
Food provides the body with the nutrients it needs to survive. Many of these critical nutrients are biological macromolecules, or large molecules, necessary for and built by living things. For example, the amino acids found in protein are needed to build healthy bone and muscle. The body uses fat molecules to build new cells, store energy, and for proper digestion. Carbohydrates are the primary source of the body’s energy. Nucleic acids contain genetic information.
-While all living things, including humans, need macromolecules in their daily diet, an imbalance of any one of them can lead to health problems. For example, eating too much fat can lead to cardiovascular problems, and too much protein can lead to problems with the kidneys. Some people think that removing whole grains, such as wheat, from one’s diet can be beneficial. However, scientists have found that to not be true for the majority of people. In fact, just the opposite may be true, because whole wheat contains more dietary fiber than other types of grains. The full research review can be found here.
+While all living things, including humans, need macromolecules in their daily diet, an imbalance of any one of them can lead to health problems. For example, eating too much fat can lead to cardiovascular problems, and too much protein can lead to problems with the kidneys. Some people think that removing whole grains, such as wheat, from one’s diet can be beneficial. However, scientists have found that to not be true for the majority of people. In fact, just the opposite may be true, because whole wheat contains more dietary fiber than other types of grains. The full research review can be found here.Stress from the beginning that most chemicals used by the body that are made up of smaller units strung together for specific functions are termed macromolecules. The same methods of combination and separation are used for all of these molecules.
diff --git a/modules/m62724/index.cnxml b/modules/m62724/index.cnxml
index b867c9503..53b2ef79a 100644
--- a/modules/m62724/index.cnxml
+++ b/modules/m62724/index.cnxml
@@ -110,7 +110,7 @@ scientific theories and models.
In the hydrolysis reaction shown here, the disaccharide maltose is broken down to form two glucose monomers with the addition of a water molecule. Note that this reaction is the reverse of the synthesis reaction shown in .
Dehydration and hydrolysis reactions are catalyzed, or “sped up,” by specific enzymes; dehydration reactions involve the formation of new bonds, requiring energy, while hydrolysis reactions break bonds and release energy. These reactions are similar for most macromolecules, but each monomer and polymer reaction is specific for its class. For example, in our bodies, food is hydrolyzed, or broken down, into smaller molecules by catalytic enzymes in the digestive system. This allows for easy absorption of nutrients by cells in the intestine. Each macromolecule is broken down by a specific enzyme. For instance, carbohydrates are broken down by amylase, sucrase, lactase, or maltase. Proteins are broken down by the enzymes pepsin and peptidase, and by hydrochloric acid. Lipids are broken down by lipases. Breakdown of these macromolecules provides energy for cellular activities.
-Visit this site to see visual representations of dehydration synthesis and hydrolysis.
+Visit this site to see visual representations of dehydration synthesis and hydrolysis.
diff --git a/modules/m62726/index.cnxml b/modules/m62726/index.cnxml
index cfa67f303..ffbf2b0e6 100644
--- a/modules/m62726/index.cnxml
+++ b/modules/m62726/index.cnxml
@@ -180,7 +180,7 @@
Benefits of CarbohydratesAre carbohydrates good for you? Some people believe that carbohydrates are bad for them and should be avoided. Some diets completely forbid carbohydrate consumption, claiming that a low-carbohydrate diet helps people to lose weight faster. However, carbohydrates have been an important part of the human diet for thousands of years; artifacts from ancient civilizations show the presence of wheat, rice, and corn in our ancestors’ storage areas.Carbohydrates should be supplemented with proteins, vitamins, and fats to be parts of a well-balanced diet. Calorie-wise, a gram of carbohydrate provides 4.3 Kcal. For comparison, fats provide 9 Kcal/g, a less desirable ratio. Carbohydrates contain soluble and insoluble elements; the insoluble part is known as fiber, which is mostly cellulose. Fiber has many uses; it promotes regular bowel movement by adding bulk, and it regulates the rate of consumption of blood glucose. Fiber also helps to remove excess cholesterol from the body: fiber binds to the cholesterol in the small intestine, then attaches to the cholesterol and prevents the cholesterol particles from entering the bloodstream, and then cholesterol exits the body via the feces. In addition, a meal containing whole grains and vegetables gives a feeling of fullness. As an immediate source of energy, glucose is broken down during the process of cellular respiration, which produces ATP, the energy currency of the cell. Without the consumption of carbohydrates, the availability of “instant energy” would be reduced. Eliminating carbohydrates from the diet may be necessary for some people, but such a step may not be healthy for everyone.
-For an additional perspective on carbohydrates, explore “Biomolecules: the Carbohydrates” through this interactive animation.
+For an additional perspective on carbohydrates, explore “Biomolecules: the Carbohydrates” through this interactive animation.
diff --git a/modules/m62730/index.cnxml b/modules/m62730/index.cnxml
index 5a08810b2..6d4991075 100644
--- a/modules/m62730/index.cnxml
+++ b/modules/m62730/index.cnxml
@@ -245,7 +245,7 @@
Steroids such as cholesterol and cortisol are composed of four fused hydrocarbon rings.
Cholesterol is the most common steroid. Cholesterol is mainly synthesized in the liver and is the precursor to many steroid hormones such as testosterone and estradiol, which are secreted by the gonads and endocrine glands. It is also the precursor to Vitamin D. Cholesterol is also the precursor of bile salts, which help in the emulsification of fats and their subsequent absorption by cells. Although cholesterol is often spoken of in negative terms by lay people, it is necessary for proper functioning of the body. It is a component of the plasma membrane of animal cells and is found within the phospholipid bilayer. Being the outermost structure in animal cells, the plasma membrane is responsible for the transport of materials and cellular recognition and it is involved in cell-to-cell communication.
-For an additional perspective on lipids, watch this video about types of fat.
+For an additional perspective on lipids, watch this video about types of fat.
diff --git a/modules/m62733/index.cnxml b/modules/m62733/index.cnxml
index 1cd4f331d..34f76dd8c 100644
--- a/modules/m62733/index.cnxml
+++ b/modules/m62733/index.cnxml
@@ -186,7 +186,7 @@
Peptide bond formation is a dehydration synthesis reaction. The carboxyl group of one amino acid is linked to the amino group of the incoming amino acid. In the process, a molecule of water is released.
The products formed by such linkages are called peptides. As more amino acids join to this growing chain, the resulting chain is known as a polypeptide. Each polypeptide has a free amino group at one end. This end is called the N terminal, or the amino terminal, and the other end has a free carboxyl group, also known as the C or carboxyl terminal. While the terms polypeptide and protein are sometimes used interchangeably, a polypeptide is technically a polymer of amino acids, whereas the term protein is used for a polypeptide or polypeptides that have combined together, often have bound non-peptide prosthetic groups, have a distinct shape, and have a unique function. After protein synthesis (translation), most proteins are modified. These are known as post-translational modifications. They may undergo cleavage or phosphorylation, or may require the addition of other chemical groups. Only after these modifications is the protein completely functional.
-Click through the steps of protein synthesis in this interactive tutorial.
+Click through the steps of protein synthesis in this interactive tutorial.
@@ -253,7 +253,7 @@
Denaturation and Protein FoldingEach protein has its own unique sequence and shape that are held together by chemical interactions. If the protein is subject to changes in temperature, changes in pH, or exposure to chemicals, the protein structure may change, losing its shape without losing its primary sequence in what is known as denaturation. Denaturation is often reversible because the primary structure of the polypeptide is conserved in the process if the denaturing agent is removed, allowing the protein to resume its function. Sometimes denaturation is irreversible, leading to loss of function. One example of irreversible protein denaturation is when an egg is fried. The albumin protein in the liquid egg white is denatured when placed in a hot pan. Not all proteins are denatured at high temperatures; for instance, bacteria that survive in hot springs have proteins that function at temperatures close to boiling. The stomach is also very acidic, has a low pH, and denatures proteins as part of the digestion process; however, the digestive enzymes of the stomach retain their activity under these conditions.Protein folding is critical to its function. It was originally thought that the proteins themselves were responsible for the folding process. Only recently was it found that often they receive assistance in the folding process from protein helpers known as chaperones (or chaperonins) that associate with the target protein during the folding process. They act by preventing aggregation of polypeptides that make up the complete protein structure, and they disassociate from the protein once the target protein is folded.
-For an additional perspective on proteins, view this animation called “Biomolecules: The Proteins.”
+For an additional perspective on proteins, view this animation called “Biomolecules: The Proteins.”
diff --git a/modules/m62735/index.cnxml b/modules/m62735/index.cnxml
index 822036baa..f2aae9844 100644
--- a/modules/m62735/index.cnxml
+++ b/modules/m62735/index.cnxml
@@ -239,7 +239,7 @@
Even though the RNA is single stranded, most RNA types show extensive intramolecular base pairing between complementary sequences, creating a predictable three-dimensional structure essential for their function.As you have learned, information flow in an organism takes place from DNA to RNA to protein. DNA dictates the structure of mRNA in a process known as transcription, and RNA dictates the structure of protein in a process known as translation. This is known as the Central Dogma of Life, which holds true for all organisms; however, exceptions to the rule occur in connection with viral infections.
-To learn more about DNA, explore the Howard Hughes Medical Institute BioInteractive animations on the topic of DNA.
+To learn more about DNA, explore the Howard Hughes Medical Institute BioInteractive animations on the topic of DNA.
diff --git a/modules/m62736/index.cnxml b/modules/m62736/index.cnxml
index 3b3f67e94..fb271eaa3 100644
--- a/modules/m62736/index.cnxml
+++ b/modules/m62736/index.cnxml
@@ -17,7 +17,7 @@
Close your eyes and picture a brick wall. What is the basic building block of that wall? A single brick, of course. Like a brick wall, your body is composed of basic building blocks called “cells.”Your body has many kinds of cells, each specialized for a specific purpose. Just as a home is made from a variety of building materials, the human body is constructed from many cell types. For example, epithelial cells protect the surface of the body and cover the organs and body cavities within. Bone cells help to support and protect the body. Immune system cells fight invading pathogens. Additionally, blood cells carry nutrients and oxygen throughout the body while removing carbon dioxide and other waste. Each of these cell types plays a vital role during the growth, development, and ongoing maintenance of the body. In spite of their enormous variety, however, cells from all organisms—even organisms as diverse as bacteria, onion, and human—share certain fundamental characteristics.
-In humans, before a cell develops into its specialized type, it is called a stem cell. A stem cell is a cell that has not undergone the changes involved in specialization. In this state, it may differentiate to become one of many different specialized cells, and it may divide to produce more stem cells. Under normal circumstances, once a cell becomes specialized, it remains that way. However, scientists have been working on coaxing stem cells in the laboratory to become a particular specialization. For example, scientists at the Cincinnati Children’s Hospital Medical Center have learned how to use stem cells to grow stomach tissue in plastic cell and tissue culture dishes. This accomplishment will enable researchers to study gastric human diseases, such as stomach cancer. You can read more about it here.
+In humans, before a cell develops into its specialized type, it is called a stem cell. A stem cell is a cell that has not undergone the changes involved in specialization. In this state, it may differentiate to become one of many different specialized cells, and it may divide to produce more stem cells. Under normal circumstances, once a cell becomes specialized, it remains that way. However, scientists have been working on coaxing stem cells in the laboratory to become a particular specialization. For example, scientists at the Cincinnati Children’s Hospital Medical Center have learned how to use stem cells to grow stomach tissue in plastic cell and tissue culture dishes. This accomplishment will enable researchers to study gastric human diseases, such as stomach cancer. You can read more about it here.
diff --git a/modules/m62738/index.cnxml b/modules/m62738/index.cnxml
index 7b62359cc..93c0828fa 100644
--- a/modules/m62738/index.cnxml
+++ b/modules/m62738/index.cnxml
@@ -57,7 +57,7 @@
(a) These Salmonella bacteria appear as tiny purple dots when viewed with a light microscope. (b) This scanning electron microscope micrograph shows Salmonella bacteria (in red) invading human cells (yellow). Even though subfigure (b) shows a different Salmonella specimen than subfigure (a), you can still observe the comparative increase in magnification and detail. (credit a: modification of work by CDC/Armed Forces Institute of Pathology, Charles N. Farmer, Rocky Mountain Laboratories; credit b: modification of work by NIAID, NIH; scale-bar data from Matt Russell)
For another perspective on cell size, try the HowBig interactive at
-this site.
+this site.
diff --git a/modules/m62740/index.cnxml b/modules/m62740/index.cnxml
index e688a3414..64488cd02 100644
--- a/modules/m62740/index.cnxml
+++ b/modules/m62740/index.cnxml
@@ -107,7 +107,7 @@
“All bacteria cause disease.” This misconception started with the germ theory of disease when it became clear that some of the most feared diseases were caused by microorganisms. In fact, very few microorganisms are actually pathogens. The balance between control of infectious diseases and reasonable sanitary standards is often misunderstood. Excess hygiene is thought to have caused an increase in asthma and other immune system imbalances between a human host and the human microbiome. Ask students if one can be “too clean.” The notion that improved hygiene has led to increases in the prevalence of allergies and asthma is called the “hygiene hypothesis.”Until recently, surface area-to-volume ratio was considered the main factor in determining the limits of cell sizes. New research opened the possibility that other factors such as avoiding predators, cell division mechanics and environment also contribute to size and shape determination. The topic is reviewed in the following article:Young, K. D. (2006). The Selective Value of Bacterial Shape. Microbiology and Molecular Biology Reviews, 70(3), 660–703. doi:10.1128 /MMBR.00001-06
-Show in class, if possible, the following video from HHMI on the discovery of microbial life by Leeuwenhoek.Use the video to discuss what set apart the single lens microscope of Leeuwenhoek. Challenge students by asking them why the rapid development of microbiology, the so-called golden age, happened in the nineteenth century, close to 200 years after the discovery of microbial life. One of the main reasons is the germ theory of disease. Once the connection was made between devastating diseases and microbes, the interest in microorganisms soared.
+Show in class, if possible, the following video from HHMI on the discovery of microbial life by Leeuwenhoek.Use the video to discuss what set apart the single lens microscope of Leeuwenhoek. Challenge students by asking them why the rapid development of microbiology, the so-called golden age, happened in the nineteenth century, close to 200 years after the discovery of microbial life. One of the main reasons is the germ theory of disease. Once the connection was made between devastating diseases and microbes, the interest in microorganisms soared.Ask students if they can think of ways in which bacteria are beneficial and write them on the board. Include the obvious ones such as probiotics; food and fermentation; and the less obvious ones such as to stimulate the immune system, biofuels, bioremediation (here mention cleaning oil spills), and synthesis of useful products (antibiotics).Ask students if a cell in a 30-meter long blue whale is considerably larger than a cell in a tiny water flea at 3 mm long. Record answers on the board. Cells are similar in size because there are constraints on how large and how small they can be and still be functionally independent entities.
diff --git a/modules/m62743/index.cnxml b/modules/m62743/index.cnxml
index f606880c5..7802e2628 100644
--- a/modules/m62743/index.cnxml
+++ b/modules/m62743/index.cnxml
@@ -128,7 +128,7 @@
The smooth endoplasmic reticulum (SER) is continuous with the RER but has few or no ribosomes on its cytoplasmic surface (). Functions of the SER include synthesis of carbohydrates, lipids, and steroid hormones; detoxification of medications and poisons; and storage of calcium ions.In muscle cells, a specialized SER called the sarcoplasmic reticulum is responsible for storage of the calcium ions that are needed to trigger the coordinated contractions of the muscle cells.
-You can watch an excellent animation of the endomembrane system here.
+You can watch an excellent animation of the endomembrane system here.
diff --git a/modules/m62744/index.cnxml b/modules/m62744/index.cnxml
index daee8e832..b14e8c9e9 100644
--- a/modules/m62744/index.cnxml
+++ b/modules/m62744/index.cnxml
@@ -77,7 +77,7 @@
Microfilaments are made of two intertwined strands of actin.
Actin is powered by ATP to assemble its filamentous form, which serves as a track for the movement of a motor protein called myosin. This enables actin to engage in cellular events requiring motion, such as cell division in eukaryotic cells and cytoplasmic streaming, which is the circular movement of the cell cytoplasm in plant cells. Actin and myosin are plentiful in muscle cells. When your actin and myosin filaments slide past each other, your muscles contract.Microfilaments also provide some rigidity and shape to the cell. They can depolymerize (disassemble) and reform quickly, thus enabling a cell to change its shape and move. White blood cells (your body’s infection-fighting cells) make good use of this ability. They can move to the site of an infection and phagocytize the pathogen.
-To see an example of a white blood cell in action, click here and watch a short time-lapse video of the cell capturing two bacteria. It engulfs one and then moves on to the other.
+To see an example of a white blood cell in action, click here and watch a short time-lapse video of the cell capturing two bacteria. It engulfs one and then moves on to the other.
diff --git a/modules/m62746/index.cnxml b/modules/m62746/index.cnxml
index 2a8c5b32d..3025c9dcc 100644
--- a/modules/m62746/index.cnxml
+++ b/modules/m62746/index.cnxml
@@ -82,7 +82,7 @@
A gap junction is a protein-lined pore that allows water and small molecules to pass between adjacent animal cells. (credit: modification of work by Mariana Ruiz Villareal)
Gap junctions develop when a set of six proteins (called connexins) in the plasma membrane arrange themselves in an elongated donut-like configuration called a connexon. When the pores (“doughnut holes”) of connexons in adjacent animal cells align, a channel between the two cells forms. Gap junctions are particularly important in cardiac muscle: The electrical signal for the muscle to contract is passed efficiently through gap junctions, allowing the heart muscle cells to contract in tandem.
-To conduct a virtual microscopy lab and review the parts of a cell, work through the steps of this interactive assignment.
+To conduct a virtual microscopy lab and review the parts of a cell, work through the steps of this interactive assignment.
diff --git a/modules/m62753/index.cnxml b/modules/m62753/index.cnxml
index 72ae156a3..157e511af 100644
--- a/modules/m62753/index.cnxml
+++ b/modules/m62753/index.cnxml
@@ -164,7 +164,7 @@ the membrane, which is inversely proportional to the solutes' concentration. In
- For a video illustrating the process of diffusion in solutions, visit this site.
+ For a video illustrating the process of diffusion in solutions, visit this site.
@@ -217,7 +217,7 @@ the membrane, which is inversely proportional to the solutes' concentration. In
Student demonstrations should include the transport of different molecules across plasma membranes, which is shown in the illustration. Molecules of oxygen, carbon dioxide, and water have no charge and so pass through membranes by simple diffusion. Na+ and K+ have a charge and require a transport protein (the sodium–potassium pump) in order to move across the plasma membrane via active transport.
-The College Board® presents an expanded diffusion/osmosis activity on which this lab investigation is based. Please see Investigation 4 in the AP Biology Investigative Labs: An Inquiry-Based Approach.
+The College Board® presents an expanded diffusion/osmosis activity on which this lab investigation is based. Please see Investigation 4 in the AP Biology Investigative Labs: An Inquiry-Based Approach.
diff --git a/modules/m62761/index.cnxml b/modules/m62761/index.cnxml
index 27302a741..5ccb46003 100644
--- a/modules/m62761/index.cnxml
+++ b/modules/m62761/index.cnxml
@@ -16,7 +16,7 @@
A hummingbird needs energy to maintain prolonged periods of flight. The bird obtains its energy from taking in food and transforming the nutrients into energy through a series of biochemical reactions. The flight muscles in birds are extremely efficient in energy production. (credit: modification of work by Cory Zanker)
Virtually every task performed by living organisms requires energy. Energy is needed to perform heavy labor and exercise. Humans also use a great deal of energy while thinking and even during sleep. In fact, the living cells of every organism constantly use energy. Nutrients and other molecules are imported, metabolized (broken down), synthesized into new molecules, modified if needed, transported around the cell, and, in some cases, distributed to the entire organism. For example, the large proteins that make up muscles are actively built from smaller molecules. Complex carbohydrates are broken down into simple sugars that the cell uses for energy. Just as energy is required to both build and demolish a building, energy is required for both the synthesis and breakdown of molecules. Additionally, signaling molecules such as hormones and neurotransmitters are actively transported between cells. Pathogenic bacteria and viruses are ingested and broken down by cells. Cells must also export waste and toxins to stay healthy. Many cells swim or move surrounding materials via the beating motion of cellular appendages such as cilia and flagella.All of the cellular processes listed above require a steady supply of energy. From where, and in what form, does this energy come? How do living cells obtain energy and how do they use it? This chapter will discuss different forms of energy and the physical laws that govern energy transfer.
-How enzymes lower the activation energy required to begin a chemical reaction in the body will also be discussed in this chapter. Enzymes are crucial for life; without them the chemical reactions required to survive would not happen fast enough for an organism to survive. For example, in an individual who lacks one of the enzymes needed to break down a type of carbohydrate known as a mucopolysaccharide, waste products accumulate in the cells and cause progressive brain damage. This deadly genetic disease is called Sanfilippo Syndrome type B or Mucopolysaccharidosis III. Previously incurable, scientists have now discovered a way to replace the missing enzyme in the brain of mice. Read more about the scientists’ research here.
+How enzymes lower the activation energy required to begin a chemical reaction in the body will also be discussed in this chapter. Enzymes are crucial for life; without them the chemical reactions required to survive would not happen fast enough for an organism to survive. For example, in an individual who lacks one of the enzymes needed to break down a type of carbohydrate known as a mucopolysaccharide, waste products accumulate in the cells and cause progressive brain damage. This deadly genetic disease is called Sanfilippo Syndrome type B or Mucopolysaccharidosis III. Previously incurable, scientists have now discovered a way to replace the missing enzyme in the brain of mice. Read more about the scientists’ research here.
diff --git a/modules/m62764/index.cnxml b/modules/m62764/index.cnxml
index 67ec5ca16..e1eacb75f 100644
--- a/modules/m62764/index.cnxml
+++ b/modules/m62764/index.cnxml
@@ -96,7 +96,7 @@
Draw examples from the class of potential vs. kinetic energy. Have several prepared before hand. If there are only a few examples given, ask the students which category your examples fall into. Include examples of chemical energy, such as the hand warmers that depend on chemical release of heat, gasoline, and gunpowder. End with the chemical energy in ATP, emphasizing it is a type of potential energy, and its role in metabolism.
-Visit this site and select “A simple pendulum” on the menu (under “Harmonic Motion”) to see the shifting kinetic (K) and potential energy (U) of a pendulum in motion.
+Visit this site and select “A simple pendulum” on the menu (under “Harmonic Motion”) to see the shifting kinetic (K) and potential energy (U) of a pendulum in motion.
@@ -144,7 +144,7 @@
Activation EnergyThere is another important concept that must be considered regarding endergonic and exergonic reactions. Even exergonic reactions require a small amount of energy input to get going before they can proceed with their energy-releasing steps. These reactions have a net release of energy, but still require some energy in the beginning. This small amount of energy input necessary for all chemical reactions to occur is called the activation energy (or free energy of activation) and is abbreviated EA ().Why would an energy-releasing, negative ∆G reaction actually require some energy to proceed? The reason lies in the steps that take place during a chemical reaction. During chemical reactions, certain chemical bonds are broken and new ones are formed. For example, when a glucose molecule is broken down, bonds between the carbon atoms of the molecule are broken. Since these are energy-storing bonds, they release energy when broken. However, to get them into a state that allows the bonds to break, the molecule must be somewhat contorted. A small energy input is required to achieve this contorted state. This contorted state is called the transition state, and it is a high-energy, unstable state. For this reason, reactant molecules don’t last long in their transition state, but very quickly proceed to the next steps of the chemical reaction. Free energy diagrams illustrate the energy profiles for a given reaction. Whether the reaction is exergonic or endergonic determines whether the products in the diagram will exist at a lower or higher energy state than both the reactants and the products. However, regardless of this measure, the transition state of the reaction exists at a higher energy state than the reactants, and thus, EA is always positive.
-Watch an animation of the move from free energy to transition state at this site.
+Watch an animation of the move from free energy to transition state at this site.
diff --git a/modules/m62768/index.cnxml b/modules/m62768/index.cnxml
index 96e5f9dba..09a221a57 100644
--- a/modules/m62768/index.cnxml
+++ b/modules/m62768/index.cnxml
@@ -109,7 +109,7 @@
Often during cellular metabolic reactions, such as the synthesis and breakdown of nutrients, certain molecules must be altered slightly in their conformation to become substrates for the next step in the reaction series. One example is during the very first steps of cellular respiration, when a molecule of the sugar glucose is broken down in the process of glycolysis. In the first step of this process, ATP is required for the phosphorylation of glucose, creating a high-energy but unstable intermediate. This phosphorylation reaction powers a conformational change that allows the phosphorylated glucose molecule to be converted to the phosphorylated sugar fructose. Fructose is a necessary intermediate for glycolysis to move forward. Here, the exergonic reaction of ATP hydrolysis is coupled with the endergonic reaction of converting glucose into a phosphorylated intermediate in the pathway. Once again, the energy released by breaking a phosphate bond within ATP was used for the phosphorylation of another molecule, creating an unstable intermediate and powering an important conformational change.
-See an interactive animation of the ATP-producing glycolysis process at this site.
+See an interactive animation of the ATP-producing glycolysis process at this site.
diff --git a/modules/m62770/index.cnxml b/modules/m62770/index.cnxml
index cbbcf9a63..34f6cdc1a 100644
--- a/modules/m62770/index.cnxml
+++ b/modules/m62770/index.cnxml
@@ -56,7 +56,7 @@
-Discuss with students the differences between passive and active transport using visuals such as this video.
+Discuss with students the differences between passive and active transport using visuals such as this video.The Science Practice Challenge Questions contain additional test questions for this section that will help you prepare for the AP exam. These questions address the following standards:
[APLO 2.10][APLO 2.17][APLO 1.2][APLO 3.24]Active transport mechanisms require the use of the cell’s energy, usually in the form of adenosine triphosphate (ATP). If a substance must move into the cell against its concentration gradient—that is, if the concentration of the substance inside the cell is greater than its concentration in the extracellular fluid (and vice versa)—the cell must use energy to move the substance. Some active transport mechanisms move small-molecular weight materials, such as ions, through the membrane. Other mechanisms transport much larger molecules.
@@ -129,7 +129,7 @@
-Visit the site to see a simulation of active transport in a sodium-potassium ATPase.
+Visit the site to see a simulation of active transport in a sodium-potassium ATPase.
@@ -161,7 +161,7 @@
-The Na+-K+ ATPase pump uses energy to move 3 Na+ ions out of a neuron for every 2 K+ ions moved into a neuron, which contributes to the net negative change of the interior of an animal nerve cell. Student models of the sodium-potassium pump in nerve cells should look similar to this illustration.
+The Na+-K+ ATPase pump uses energy to move 3 Na+ ions out of a neuron for every 2 K+ ions moved into a neuron, which contributes to the net negative change of the interior of an animal nerve cell. Student models of the sodium-potassium pump in nerve cells should look similar to this illustration.Answer to Think About It question: A decrease in pH means an increase in positively charged H+ ions, and an increase in the electrical gradient across the membrane. The transport of amino acids into the cell will increase.
diff --git a/modules/m62772/index.cnxml b/modules/m62772/index.cnxml
index a3cd5947d..ced7cf94c 100644
--- a/modules/m62772/index.cnxml
+++ b/modules/m62772/index.cnxml
@@ -87,7 +87,7 @@
-Ask students to consider how large polar molecules required by cells, such as proteins and polysaccharides, can enter cells when they are unable to cross cell membranes. These molecules enter cells through the active transport mechanism of endocytosis. This video on endocytosis and exocytosis can be used to demonstrate this information.
+Ask students to consider how large polar molecules required by cells, such as proteins and polysaccharides, can enter cells when they are unable to cross cell membranes. These molecules enter cells through the active transport mechanism of endocytosis. This video on endocytosis and exocytosis can be used to demonstrate this information.
@@ -136,7 +136,7 @@
In receptor-mediated endocytosis, uptake of substances by the cell is targeted to a single type of substance that binds to the receptor on the external surface of the cell membrane. (credit: modification of work by Mariana Ruiz Villareal)
In receptor-mediated endocytosis, as in phagocytosis, clathrin is attached to the cytoplasmic side of the plasma membrane. If uptake of a compound is dependent on receptor-mediated endocytosis and the process is ineffective, the material will not be removed from the tissue fluids or blood. Instead, it will stay in those fluids and increase in concentration. Some human diseases are caused by the failure of receptor-mediated endocytosis. For example, the form of cholesterol termed low-density lipoprotein or LDL (also referred to as “bad” cholesterol) is removed from the blood by receptor-mediated endocytosis. In the human genetic disease familial hypercholesterolemia, the LDL receptors are defective or missing entirely. People with this condition have life-threatening levels of cholesterol in their blood, because their cells cannot clear LDL particles from their blood.Although receptor-mediated endocytosis is designed to bring specific substances that are normally found in the extracellular fluid into the cell, other substances may gain entry into the cell at the same site. Flu viruses, diphtheria, and cholera toxin all have sites that cross-react with normal receptor-binding sites and gain entry into cells.
-See receptor-mediated endocytosis in action, and click on different parts for a focused animation.
+See receptor-mediated endocytosis in action, and click on different parts for a focused animation.
diff --git a/modules/m62773/index.cnxml b/modules/m62773/index.cnxml
index 0cb5ad88e..84f3060c5 100644
--- a/modules/m62773/index.cnxml
+++ b/modules/m62773/index.cnxml
@@ -91,7 +91,7 @@
-Educreations is a free iPad app that allows students to build electronic slides with narration. If student have access to an iPad, have students use the app to construct a model of the plasma membrane and its molecular components complete with an audio narrative. For more information, go here.
+Educreations is a free iPad app that allows students to build electronic slides with narration. If student have access to an iPad, have students use the app to construct a model of the plasma membrane and its molecular components complete with an audio narrative. For more information, go here.Students may think that all cell membranes are identical. Discuss with students not all membranes are identical, and different membranes differ in composition. While all membranes consist of phospholipid bilayers, different membranes will contain unique, proteins that relate to the function of the cell or organelle. In addition, membrane composition can differ depending on how fluid the membrane needs to be. Membranes can differ in saturated fatty acid content (increasing rigidity) versus unsaturated fatty acid content, as well as cholesterol content, which protects the fluidity of the membrane from temperature change.The cell membrane has different lipid and protein compositions in distinct types of cells and may have therefore specific names for certain cell types, such as: Sarcolemma in myocytes, Oolemma in oocytes, and Axolemma in neuronal processes–axons.
@@ -157,7 +157,7 @@
Thus, if saturated fatty acids, with their straight tails, are compressed by decreasing temperatures, they press in on each other, making a dense and fairly rigid membrane. If unsaturated fatty acids are compressed, the “kinks” in their tails elbow adjacent phospholipid molecules away, maintaining some space between the phospholipid molecules. This “elbow room” helps to maintain fluidity in the membrane at temperatures at which membranes with saturated fatty acid tails in their phospholipids would “freeze” or solidify. The relative fluidity of the membrane is particularly important in a cold environment. A cold environment tends to compress membranes composed largely of saturated fatty acids, making them less fluid and more susceptible to rupturing. Many organisms (fish are one example) are capable of adapting to cold environments by changing the proportion of unsaturated fatty acids in their membranes in response to the lowering of the temperature.
-Visit this site to see animations of the fluidity and mosaic quality of membranes.
+Visit this site to see animations of the fluidity and mosaic quality of membranes.
diff --git a/modules/m62778/index.cnxml b/modules/m62778/index.cnxml
index 231e5f7c2..668563b6b 100644
--- a/modules/m62778/index.cnxml
+++ b/modules/m62778/index.cnxml
@@ -78,7 +78,7 @@
Induced Fit and Enzyme FunctionFor many years, scientists thought that enzyme-substrate binding took place in a simple “lock-and-key” fashion. This model asserted that the enzyme and substrate fit together perfectly in one instantaneous step. However, current research supports a more refined view called induced fit (). The induced-fit model expands upon the lock-and-key model by describing a more dynamic interaction between enzyme and substrate. As the enzyme and substrate come together, their interaction causes a mild shift in the enzyme’s structure that confirms an ideal binding arrangement between the enzyme and the transition state of the substrate. This ideal binding maximizes the enzyme’s ability to catalyze its reaction.
-View an animation of induced fit at this website.
+View an animation of induced fit at this website.
@@ -103,7 +103,7 @@
This lab investigation is an application of LO 4.17 and Science Practice 5.1 because you will analyze experimental data to determine how various environment conditions affect enzyme structure and function and, thus, the rate of enzyme-catalyzed reactions.
-An expanded lab investigation for enzymes, involving determining the effect of pH on the action of turnip peroxidase, is available from the College Board’s ® AP Biology Investigative Labs: An Inquiry-Based Approach, Investigation 13.
+An expanded lab investigation for enzymes, involving determining the effect of pH on the action of turnip peroxidase, is available from the College Board’s ® AP Biology Investigative Labs: An Inquiry-Based Approach, Investigation 13.
diff --git a/modules/m62780/index.cnxml b/modules/m62780/index.cnxml
index 7c1675737..79e63eadc 100644
--- a/modules/m62780/index.cnxml
+++ b/modules/m62780/index.cnxml
@@ -17,7 +17,7 @@
The plasma membrane, which is also called the cell membrane, has many functions; but, the most basic one is to define the borders and act as gatekeeper for the cell. The plasma membrane is selectively permeable, meaning some molecules can freely enter or leave the cell. Others require help from specialized structures, other molecules, or require energy in order to cross. One example of a molecule that assists other molecules across the plasma membrane is a protein called NPC1. This protein is involved in moving cholesterol and other types of fats across the plasma membrane. Some people have a genetic condition resulting in improperly functioning NPC1. As a result, excessive cholesterol accumulates within cells causing a condition called NPC Disease.Scientists from the Albert Einstein College of Medicine, Harvard Medical School, and the Whitehead Institute for Biomedical Research discovered that the Ebola virus also uses NPC1 to hitch a ride into cells and replicate. The scientists used mice that lacked the NPC1 protein to test this hypothesis. When the scientists tried to infect these mice with Ebola, none of the mice got sick. Then they tried to infect mice with partially functioning NPC1 and found that they got sick, but did not die. In other words, without properly functioning NPC1, the Ebola virus cannot infect a mouse. If this pattern also exists in humans, it means that anyone with NPC Disease and its subsequent problem with high cholesterol may also be protected from Ebola.
-The complete research report can be found here.
+The complete research report can be found here.
diff --git a/modules/m62784/index.cnxml b/modules/m62784/index.cnxml
index 617cfac81..78fb0eb6d 100644
--- a/modules/m62784/index.cnxml
+++ b/modules/m62784/index.cnxml
@@ -17,7 +17,7 @@
This geothermal energy plant transforms thermal energy from deep in the ground into electrical energy, which can be easily used. (credit: modification of work by the U.S. Department of Defense)
The electrical energy plant in converts energy from one form to another form that can be more easily used. This type of generating plant starts with underground thermal energy (heat) and transforms it into electrical energy that will be transported to homes and factories. Like a generating plant, plants and animals also must take in energy from the environment and convert it into a form that their cells can use. Energy enters an organism’s body in one form and is converted into another form that can fuel the organism’s life functions. In the process of photosynthesis, plants and other photosynthetic producers take in energy in the form of light (solar energy) and convert it into chemical energy, glucose, which stores this energy in its chemical bonds. Then, a series of metabolic pathways, collectively called cellular respiration, extract the energy from the carbon–carbon bonds of glucose and convert it into a form that all living things can use—both producers, such as plants, and consumers, such as animals.
- Nearly all organisms perform glycolysis, the first part of both aerobic and anaerobic respiration. One of the key enzymes of glycolysis is pyruvate kinase. Without this enzyme, an organism will die because it is unable to convert nutrients into the energy it needs for survival. Scientists have taken advantage of that fact by blocking pyruvate kinase in some deadly parasites, such as the ones that cause African Sleeping Sickness and Chagas disease. Read more about this research here.
+ Nearly all organisms perform glycolysis, the first part of both aerobic and anaerobic respiration. One of the key enzymes of glycolysis is pyruvate kinase. Without this enzyme, an organism will die because it is unable to convert nutrients into the energy it needs for survival. Scientists have taken advantage of that fact by blocking pyruvate kinase in some deadly parasites, such as the ones that cause African Sleeping Sickness and Chagas disease. Read more about this research here.Before students begin this chapter, it is useful to review these concepts: Cell structure including mitochondria structure; structure of macromolecules including glucose, lipids, and proteins; transport of molecules across membranes including diffusion and facilitated transport.
diff --git a/modules/m62787/index.cnxml b/modules/m62787/index.cnxml
index f4adf9233..18633f9a8 100644
--- a/modules/m62787/index.cnxml
+++ b/modules/m62787/index.cnxml
@@ -106,7 +106,7 @@
Discuss with students how glycolysis is considered to be the oldest and most conserved metabolic pathway. Discuss with students how this process is found in all domains of life. Glycolysis is an anaerobic process, and the early atmosphere of Earth had very little oxygen. This means that glycolysis could have taken place in early prokaryotes because it does not require oxygen. Glycolysis takes place in the cell cytosol, and not the mitochondrial membrane. Prokaryotes, which don’t have membrane bound organelles, can carry out glycolysis.
-Introduce the process of glycolysis using visuals such as this video.
+Introduce the process of glycolysis using visuals such as this video.You have read that nearly all of the energy used by living cells comes to them in the bonds of the sugar, glucose. Glycolysis is the first step in the breakdown of glucose to extract energy for cellular metabolism. Nearly all living organisms carry out glycolysis as part of their metabolism. The process does not use oxygen and is therefore anaerobic. Glycolysis takes place in the cytoplasm of both prokaryotic and eukaryotic cells. Glucose enters heterotrophic cells in two ways. One method is through secondary active transport in which the transport takes place against the glucose concentration gradient. The other mechanism uses a group of integral proteins called GLUT proteins, also known as glucose transporter proteins. These transporters assist in the facilitated diffusion of glucose.Glycolysis begins with the six carbon ring-shaped structure of a single glucose molecule and ends with two molecules of a three-carbon sugar called pyruvate. Glycolysis consists of two distinct phases. The first part of the glycolysis pathway traps the glucose molecule in the cell and uses energy to modify it so that the six-carbon sugar molecule can be split evenly into the two three-carbon molecules. The second part of glycolysis extracts energy from the molecules and stores it in the form of ATP and NADH, the reduced form of NAD+.
@@ -131,7 +131,7 @@
Step 9. Enolase catalyzes the ninth step. This enzyme causes 2-phosphoglycerate to lose water from its structure; this is a dehydration reaction, resulting in the formation of a double bond that increases the potential energy in the remaining phosphate bond and produces phosphoenolpyruvate (PEP).Step 10. The last step in glycolysis is catalyzed by the enzyme pyruvate kinase (the enzyme in this case is named for the reverse reaction of pyruvate’s conversion into PEP) and results in the production of a second ATP molecule by substrate-level phosphorylation and the compound pyruvic acid (or its salt form, pyruvate). Many enzymes in enzymatic pathways are named for the reverse reactions, since the enzyme can catalyze both forward and reverse reactions (these may have been described initially by the reverse reaction that takes place in vitro, under non-physiological conditions).
-Gain a better understanding of the breakdown of glucose by glycolysis by visiting this site to see the process in action.
+Gain a better understanding of the breakdown of glucose by glycolysis by visiting this site to see the process in action.
diff --git a/modules/m62788/index.cnxml b/modules/m62788/index.cnxml
index fe817c608..20bf6f6d7 100644
--- a/modules/m62788/index.cnxml
+++ b/modules/m62788/index.cnxml
@@ -104,7 +104,7 @@
-Introduce the citric acid cycle using visuals such as this video.
+Introduce the citric acid cycle using visuals such as this video.The Science Practice Challenge Questions contain additional test questions for this section that will help you prepare for the AP exam. These questions address the following standards:
[APLO 2.1][APLO 2.5][APLO 2.16][APLO 2.17][APLO 2.18]If oxygen is available, aerobic respiration will go forward. In eukaryotic cells, the pyruvate molecules produced at the end of glycolysis are transported into mitochondria. There, pyruvate will be transformed into an acetyl group that will be picked up and activated by a carrier compound called coenzyme A (CoA). The resulting compound is called acetyl CoA. CoA is made from vitamin B5, pantothenic acid. Acetyl CoA can be used in a variety of ways by the cell, but its major function is to deliver the acetyl group derived from pyruvate to the next stage of the pathway in glucose catabolism.
@@ -139,7 +139,7 @@
Step 6. Step six is a dehydrogenation process that converts succinate into fumarate. Two hydrogen atoms are transferred to FAD, producing FADH2. The energy contained in the electrons of these atoms is insufficient to reduce NAD+ but adequate to reduce FAD. Unlike NADH, this carrier remains attached to the enzyme and transfers the electrons to the electron transport chain directly. This process is made possible by the localization of the enzyme catalyzing this step inside the inner membrane of the mitochondrion.Step 7. Water is added to fumarate during step seven, and malate is produced. The last step in the citric acid cycle regenerates oxaloacetate by oxidizing malate. Another molecule of NADH is produced in the process.
-Click through each step of the citric acid cycle here.
+Click through each step of the citric acid cycle here.
diff --git a/modules/m62789/index.cnxml b/modules/m62789/index.cnxml
index eca22b6b4..c79382c38 100644
--- a/modules/m62789/index.cnxml
+++ b/modules/m62789/index.cnxml
@@ -77,7 +77,7 @@
-Introduce oxidative phosphorylation using visuals such as this video.Have students create a visual representation that shows an overview of glycolysis and the citric acid cycle and how the cycles relate to one another.
+Introduce oxidative phosphorylation using visuals such as this video.Have students create a visual representation that shows an overview of glycolysis and the citric acid cycle and how the cycles relate to one another.The Science Practice Challenge Questions contain additional test questions for this section that will help you prepare for the AP exam. These questions address the following standards:
[APLO 2.5][APLO 2.15][APLO 2.18][APLO 2.22]You have just read about two pathways Introduce glucose catabolism—glycolysis and the citric acid cycle—that generate ATP. Most of the ATP generated during the aerobic catabolism of glucose, however, is not generated directly from these pathways. Rather, it is derived from a process that begins with moving electrons through a series of electron transporters that undergo redox reactions. This causes hydrogen ions to accumulate within the intermembranous space. Therefore, a concentration gradient forms in which hydrogen ions diffuse out of the intermembranous space into the mitochondrial matrix by passing through ATP synthase. The current of hydrogen ions powers the catalytic action of ATP synthase, which phosphorylates ADP, producing ATP.
@@ -172,7 +172,7 @@
This activity is an application of Learning Objective 2.4 and Science Practices 1.4 and 3.1 and Learning Objective 2.5 and Science Practice 6.2 because students will have the opportunity to create a model of the electron transport chain, allowing students to study and discuss the components of the electron transport chain that allow organisms to capture, store, and use free energy.
-An extended lab investigation on cellular respiration is available from the College Board®. This activity involves respirometry of plant seeds. It is available from the College Board’s® AP Biology Investigative Labs: An Inquiry-Based Approach, Investigation 6.
+An extended lab investigation on cellular respiration is available from the College Board®. This activity involves respirometry of plant seeds. It is available from the College Board’s® AP Biology Investigative Labs: An Inquiry-Based Approach, Investigation 6.The Think About It questions are applications of Learning Objective 2.4 and Science Practices 1.4 and 3.1 and Learning Objective 2.5 and Science Practice 6.2 because students are provided with situations that raise questions about cellular respiration and are then asked to explain the effects of factors that affect the process. Students are also connecting the structure of the mitochondrion to its role in cellular respiration.Possible answers to Activity:
diff --git a/modules/m62790/index.cnxml b/modules/m62790/index.cnxml
index e10c62a53..e7acae674 100644
--- a/modules/m62790/index.cnxml
+++ b/modules/m62790/index.cnxml
@@ -75,7 +75,7 @@
-Discuss with students the role of fermentation in processes such as the production of bread, yogurt, alcohol, and fuels. For example as discussed in this video.
+Discuss with students the role of fermentation in processes such as the production of bread, yogurt, alcohol, and fuels. For example as discussed in this video.Students may not realize that fermentation functions to regenerate NAD+; students may think that fermentation only functions to produce additional ATP. Fermentation can produce ATP as long as there is enough NAD+ to accept electrons. Without NAD+ regeneration from NADH, glycolysis will deplete NAD+ and come to a stop.
@@ -83,7 +83,7 @@
The Science Practice Challenge Questions contain additional test questions for this section that will help you prepare for the AP exam. These questions address the following standards:
[APLO 2.21][APLO 2.24][APLO 4.14][APLO 4.26]In aerobic respiration, the final electron acceptor is an oxygen molecule, O2. If aerobic respiration occurs, then ATP will be produced using the energy of high-energy electrons carried by NADH or FADH2 to the electron transport chain. If aerobic respiration does not occur, NADH must be reoxidized to NAD+ for reuse as an electron carrier for the glycolytic pathway to continue. How is this done? Some living systems use an organic molecule as the final electron acceptor. Processes that use an organic molecule to regenerate NAD+ from NADH are collectively referred to as fermentation. In contrast, in some living systems, the electron transport chain (ETC) uses an inorganic molecule as a final electron acceptor, which is called anaerobic cellular respiration. Both processes allow organisms to convert energy for their use in the absence of oxygen.
- Visit this site to see fermentation in action.
+ Visit this site to see fermentation in action.
diff --git a/modules/m62791/index.cnxml b/modules/m62791/index.cnxml
index 26de838e4..af2ce4066 100644
--- a/modules/m62791/index.cnxml
+++ b/modules/m62791/index.cnxml
@@ -66,7 +66,7 @@
-Discuss with students how metabolic reactions include both the breakdown of molecules and the synthesis of larger molecules. For example as discussed in Anatomy and Physiology here.Metabolic processes are constantly taking place in the body. Metabolism is the sum of all of the chemical reactions that are involved in catabolism and anabolism. The reactions governing the breakdown of food to obtain energy are called catabolic reactions. Conversely, anabolic reactions use the energy produced by catabolic reactions to synthesize larger molecules from smaller ones, such as when the body forms proteins by stringing together amino acids. Both sets of reactions are critical to maintaining life.
+Discuss with students how metabolic reactions include both the breakdown of molecules and the synthesis of larger molecules. For example as discussed in Anatomy and Physiology here.Metabolic processes are constantly taking place in the body. Metabolism is the sum of all of the chemical reactions that are involved in catabolism and anabolism. The reactions governing the breakdown of food to obtain energy are called catabolic reactions. Conversely, anabolic reactions use the energy produced by catabolic reactions to synthesize larger molecules from smaller ones, such as when the body forms proteins by stringing together amino acids. Both sets of reactions are critical to maintaining life.Because catabolic reactions produce energy and anabolic reactions use energy, ideally, energy usage would balance the energy produced. If the net energy change is positive (catabolic reactions release more energy than the anabolic reactions use), then the body stores the excess energy by building fat molecules for long-term storage. On the other hand, if the net energy change is negative (catabolic reactions release less energy than anabolic reactions use), the body uses stored energy to compensate for the deficiency of energy released by catabolism. Have students create a visual representation of the interaction of various metabolic pathways. For example:
diff --git a/modules/m62792/index.cnxml b/modules/m62792/index.cnxml
index f172ff1f0..75b4cbc01 100644
--- a/modules/m62792/index.cnxml
+++ b/modules/m62792/index.cnxml
@@ -101,7 +101,7 @@
Electron Transport ChainSpecific enzymes of the electron transport chain are unaffected by feedback inhibition, but the rate of electron transport through the pathway is affected by the levels of ADP and ATP. Greater ATP consumption by a cell is indicated by a buildup of ADP. As ATP usage decreases, the concentration of ADP decreases, and now, ATP begins to build up in the cell. This change in the relative concentration of ADP to ATP triggers the cell to slow down the electron transport chain.
-Visit this site to see an animation of the electron transport chain and ATP synthesis.
+Visit this site to see an animation of the electron transport chain and ATP synthesis.
diff --git a/modules/m62793/index.cnxml b/modules/m62793/index.cnxml
index 48d729d0e..1f3da4149 100644
--- a/modules/m62793/index.cnxml
+++ b/modules/m62793/index.cnxml
@@ -18,7 +18,7 @@
All biological processes require energy. To get this energy, many organisms access stored energy by eating, that is, by ingesting other organisms. But where does the stored energy in food originate? Almost all of this energy can be traced back to photosynthesis.
-Photosynthetic organisms are the basis for almost all of the food webs on the planet. For example, the Indian River Lagoon, a 156 mile mixture of fresh and salt water along the eastern coast of Florida, depends on its sea grass for the survival of its marine life. Unfortunately, when certain algal phytoplankton species grow in overabundance, it destroys the sea grass. Scientists conducted a 16 year study of algal blooms and found that extreme climate conditions, such as cold weather and low rainfall, change which particular species of phytoplankton is more likely to bloom, resulting in a die-off of sea grass, decrease in other marine life, and changes in salinity. The research study can be found here.
+Photosynthetic organisms are the basis for almost all of the food webs on the planet. For example, the Indian River Lagoon, a 156 mile mixture of fresh and salt water along the eastern coast of Florida, depends on its sea grass for the survival of its marine life. Unfortunately, when certain algal phytoplankton species grow in overabundance, it destroys the sea grass. Scientists conducted a 16 year study of algal blooms and found that extreme climate conditions, such as cold weather and low rainfall, change which particular species of phytoplankton is more likely to bloom, resulting in a die-off of sea grass, decrease in other marine life, and changes in salinity. The research study can be found here.Having studied the laws of thermodynamics in a previous chapter, it should be no surprise that the sun is a source of all the energy used by living organisms, that this energy can be converted, stored, and used, and that there is an interdependence between organisms with regard to that energy.
diff --git a/modules/m62794/index.cnxml b/modules/m62794/index.cnxml
index 515cf5bb4..67cfe6495 100644
--- a/modules/m62794/index.cnxml
+++ b/modules/m62794/index.cnxml
@@ -209,7 +209,7 @@
Photosynthesis takes place in two stages: light dependent reactions and the Calvin cycle. Light-dependent reactions, which take place in the thylakoid membrane, use light energy to make ATP and NADPH. The Calvin cycle, which takes place in the stroma, uses energy derived from these compounds to make G3P from CO2.
-Click the link to learn more about photosynthesis.
+Click the link to learn more about photosynthesis.
diff --git a/modules/m62795/index.cnxml b/modules/m62795/index.cnxml
index b2505a0ae..e6f2279fc 100644
--- a/modules/m62795/index.cnxml
+++ b/modules/m62795/index.cnxml
@@ -310,7 +310,7 @@
As in the intermembrane space of the mitochondria during cellular respiration, the buildup of hydrogen ions inside the thylakoid lumen creates a concentration gradient. The passive diffusion of hydrogen ions from high concentration (in the thylakoid lumen) to low concentration (in the stroma) is harnessed to create ATP, just as in the electron transport chain of cellular respiration. The ions build up energy because of diffusion and because they all have the same electrical charge, repelling each other.To release this energy, hydrogen ions will rush through any opening, similar to water jetting through a hole in a dam. In the thylakoid, that opening is a passage through a specialized protein channel called the ATP synthase. The energy released by the hydrogen ion stream allows ATP synthase to attach a third phosphate group to ADP, which forms a molecule of ATP (). The flow of hydrogen ions through ATP synthase is called chemiosmosis because the ions move from an area of high to an area of low concentration through a semi-permeable structure.
-Visit this site and click through the animation to view the process of photosynthesis within a leaf.
+Visit this site and click through the animation to view the process of photosynthesis within a leaf.
diff --git a/modules/m62796/index.cnxml b/modules/m62796/index.cnxml
index fbd9a8895..db1c3e823 100644
--- a/modules/m62796/index.cnxml
+++ b/modules/m62796/index.cnxml
@@ -124,7 +124,7 @@
Stage 3: RegenerationInterestingly, at this point, only one of the G3P molecules leaves the Calvin cycle and is sent to the cytoplasm to contribute to the formation of other compounds needed by the plant. Because the G3P exported from the chloroplast has three carbon atoms, it takes three “turns” of the Calvin cycle to fix enough net carbon to export one G3P. But each turn makes two G3Ps, thus three turns make six G3Ps. One is exported while the remaining five G3P molecules remain in the cycle and are used to regenerate RuBP, which enables the system to prepare for more CO2 to be fixed. Three more molecules of ATP are used in these regeneration reactions.
-This link leads to an animation of the Calvin cycle. Click stage 1, stage 2, and then stage 3 to see G3P and ATP regenerate to form RuBP.
+This link leads to an animation of the Calvin cycle. Click stage 1, stage 2, and then stage 3 to see G3P and ATP regenerate to form RuBP.
@@ -198,7 +198,7 @@ in chloroplasts, and aerobic cellular respiration releases energy by using oxyge
This activity and question are applications of Learning Objective 2.4 and science practices 1.4 and 3.1 because students are creating and using a representation to explore the link between photosynthesis and cellular respiration, two processes that organisms use to capture, store, and use free energy.
-Possible answer: Search for free images that show what the model or diagram should look like here or here.
+Possible answer: Search for free images that show what the model or diagram should look like here or here.Both cellular respiration and photosynthesis occur in/on double-membrane organelles in the cell. Both processes use electron carriers to shuttle electrons to and between membrane proteins that pump protons. The pumping of protons creates an electrochemical gradient that drives the synthesis of ATP.Section SummaryUsing the energy carriers formed in the first steps of photosynthesis, the light-independent reactions, or the Calvin cycle, take in CO2 from the environment. An enzyme, RuBisCO, catalyzes a reaction with CO2 and another molecule, RuBP. After three cycles, a three-carbon molecule of G3P leaves the cycle to become part of a carbohydrate molecule. The remaining G3P molecules stay in the cycle to be regenerated into RuBP, which is then ready to react with more CO2. Photosynthesis forms an energy cycle with the process of cellular respiration. Plants need both photosynthesis and respiration for their ability to function in both the light and dark, and to be able to interconvert essential metabolites. Therefore, plants contain both chloroplasts and mitochondria.
diff --git a/modules/m62797/index.cnxml b/modules/m62797/index.cnxml
index 268399029..c4707b88c 100644
--- a/modules/m62797/index.cnxml
+++ b/modules/m62797/index.cnxml
@@ -16,7 +16,7 @@
Have you ever become separated from a friend while in a crowd? If so, you know the challenge of searching for someone when surrounded by thousands of other people. If you and your friend have cell phones, your chances of finding each other are good. A cell phone’s ability to send and receive messages makes it an ideal communication device. (credit: modification of work by Vincent and Bella Productions)
Imagine what life would be like if you and the people around you could not communicate. You would not be able to express your wishes, nor could you ask questions to find out more about your environment. Social organization is dependent on communication between the individuals; without communication, society would fall apart.As with people, it is vital for a cell to interact with its environment. This is true whether it is a unicellular organism or one of many cells forming a larger organism. In order to respond to external stimuli, cells have developed complex mechanisms of communication that can receive a message, transfer the information across the plasma membrane, and produce changes within the cell in response to the message. In multicellular organisms, cells send and receive chemical messages constantly to coordinate the actions of distant organs, tissues, and cells.
-While the necessity for cellular communication in larger organisms seems obvious, even single-celled organisms communicate with each other. Yeast cells signal each other to aid in mating. Some forms of bacteria coordinate their actions in order to form large complexes called biofilms () or to organize the production of toxins to remove competing organisms. The ability of cells to communicate through chemical signals originated in single cells and was essential for the evolution of multicellular organisms.Cell signaling is vital to the survival of organisms. For example, chemical signals tell cells when to make hormones such as insulin. Cell division also depends on chemical signals. When the chemical signals do not function properly, cells can divide uncontrollably, forming cancerous tumors. Scientists recently discovered a cell signaling pathway that protects cancer cells from being killed by the body’s immune system. The hope is to use this knowledge to create treatments that target this cell signaling pathway so that the cancer cells self destruct. More about that can be found here: “Scientists pinpoint a new line of defense used by cancer cells.”
+While the necessity for cellular communication in larger organisms seems obvious, even single-celled organisms communicate with each other. Yeast cells signal each other to aid in mating. Some forms of bacteria coordinate their actions in order to form large complexes called biofilms () or to organize the production of toxins to remove competing organisms. The ability of cells to communicate through chemical signals originated in single cells and was essential for the evolution of multicellular organisms.Cell signaling is vital to the survival of organisms. For example, chemical signals tell cells when to make hormones such as insulin. Cell division also depends on chemical signals. When the chemical signals do not function properly, cells can divide uncontrollably, forming cancerous tumors. Scientists recently discovered a cell signaling pathway that protects cancer cells from being killed by the body’s immune system. The hope is to use this knowledge to create treatments that target this cell signaling pathway so that the cancer cells self destruct. More about that can be found here: “Scientists pinpoint a new line of defense used by cancer cells.”Ask students to think about how a cell phone works. Draw on the board the sequence: signal, phone hardware, sound. What happens after the call? Immediate action if it is urgent, delayed action if not, or simply ignore and delete if the message is deemed irrelevant. Cells function similarly. The body is abuzz with messages. Not all cells can receive all messages, and the response to the same message can and should be different depending on the type of targeted cell.
diff --git a/modules/m62798/index.cnxml b/modules/m62798/index.cnxml
index 9242cc9f5..74bee8185 100644
--- a/modules/m62798/index.cnxml
+++ b/modules/m62798/index.cnxml
@@ -112,7 +112,7 @@
Ask students if all nervous system signaling should be mediated by ligand-gated receptors, which render a rapid and short duration response. Skeletal muscles use ligand-gated receptors, which give rapid and time-limited responses. Some situations require a lasting effect. Smooth muscles carry G-protein-linked receptors because smooth muscle responses, bladder, intestine, etc., have prolonged action. This is an example of the same ligand, acetylcholine, binding to two different types of receptors.
-Distribute large sheets of paper and markers. Divide the class in groups and assign each group a specific type of receptor: ion channel-linked receptors (gated ion channels), G-protein-linked receptors, receptor tyrosine kinases, and internal (intracellular) receptors. More than one group of students may work on the same receptor. Ask students to set up a concept map starting with signal types: water soluble molecules or lipophilic molecules for each receptor molecule. For each receptor type, diagram the second messenger and amplification scheme. Allow enough time to create the posters and ask each group to present the receptor to the class. Here the goal is to divide and conquer the receptors because cellular signaling is confusing. Show this animation from Davidson College in class or provide a link for later view by students.
+Distribute large sheets of paper and markers. Divide the class in groups and assign each group a specific type of receptor: ion channel-linked receptors (gated ion channels), G-protein-linked receptors, receptor tyrosine kinases, and internal (intracellular) receptors. More than one group of students may work on the same receptor. Ask students to set up a concept map starting with signal types: water soluble molecules or lipophilic molecules for each receptor molecule. For each receptor type, diagram the second messenger and amplification scheme. Allow enough time to create the posters and ask each group to present the receptor to the class. Here the goal is to divide and conquer the receptors because cellular signaling is confusing. Show this animation from Davidson College in class or provide a link for later view by students.The Science Practice Challenge Questions contain contains additional test questions for this section that will help you prepare for the AP exam. These questions address the following standards:
diff --git a/modules/m62799/index.cnxml b/modules/m62799/index.cnxml
index fa643f030..b8b43a856 100644
--- a/modules/m62799/index.cnxml
+++ b/modules/m62799/index.cnxml
@@ -52,7 +52,7 @@
Ask students what would happen if suddenly the fire alarm went off. It should trigger the “fight-or-flight” response. Some organs must be activated for the response: skeletal muscle, heart, and the release of glucose from liver. Other organs have their activities dampened: the stomach halts digestion and salivary glands stop production.
-Ask students what happens if they get a loud alarm sound while eating. The likely response is that nauseous feeling and digestion cut short, courtesy of our sympathetic system. The same signal that activates all the systems needed for survival also shuts down the systems which are not essential for the rapid reaction needed to escape danger. An animation of fight-or-flight response can be seen here.
+Ask students what happens if they get a loud alarm sound while eating. The likely response is that nauseous feeling and digestion cut short, courtesy of our sympathetic system. The same signal that activates all the systems needed for survival also shuts down the systems which are not essential for the rapid reaction needed to escape danger. An animation of fight-or-flight response can be seen here.The Science Practice Challenge Questions contain additional test questions for this section that will help you prepare for the AP exam. These questions address the following standards:
[APLO 3.33][APLO 3.4][APLO 4.22][APLO 2.5][APLO 3.32][APLO 3.38]Once a ligand binds to a receptor, the signal is transmitted through the membrane and into the cytoplasm. Continuation of a signal in this manner is called signal transduction. Signal transduction only occurs with cell-surface receptors because internal receptors are able to interact directly with DNA in the nucleus to initiate protein synthesis.
@@ -79,7 +79,7 @@
Methods of Intracellular SignalingThe induction of a signaling pathway depends on the modification of a cellular component by an enzyme. There are numerous enzymatic modifications that can occur, and they are recognized in turn by the next component downstream. The following are some of the more common events in intracellular signaling.
-Observe an animation of cell signaling at this site.
+Observe an animation of cell signaling at this site.
diff --git a/modules/m62800/index.cnxml b/modules/m62800/index.cnxml
index 266fe8bc0..dd816c5ea 100644
--- a/modules/m62800/index.cnxml
+++ b/modules/m62800/index.cnxml
@@ -116,7 +116,7 @@
-Remind students that response to the environment is one of the characteristics of life. Organisms must be able to perceive changes in the environment in order to survive. Ask students to make a list of which changes an organism should perceive to survive. The list may include availability of nutrients, changes in physical conditions, perception of noxious chemicals and the presence of predators. Multicellular organisms must be able to coordinate the responses of their cells. The integration of responses first requires signal transmission, then reception and transduction. The signaling pathways can easily confuse students. Many enzymes and other proteins are involved in cascading reactions. This website offers clear explanations of signal transduction and a number of activities to engage students using the flight-or-flight response as an example. The activity, “Dealing Signals,” can help students understand signaling pathways asks them to act as the components of a signaling pathway by taking cues from cell communication cards. Students mimic signaling pathways by running in place, interacting with specific classmates by either bumping into them or holding them, and leaning or lifting arms to simulate conformational changes.
+Remind students that response to the environment is one of the characteristics of life. Organisms must be able to perceive changes in the environment in order to survive. Ask students to make a list of which changes an organism should perceive to survive. The list may include availability of nutrients, changes in physical conditions, perception of noxious chemicals and the presence of predators. Multicellular organisms must be able to coordinate the responses of their cells. The integration of responses first requires signal transmission, then reception and transduction. The signaling pathways can easily confuse students. Many enzymes and other proteins are involved in cascading reactions. This website offers clear explanations of signal transduction and a number of activities to engage students using the flight-or-flight response as an example. The activity, “Dealing Signals,” can help students understand signaling pathways asks them to act as the components of a signaling pathway by taking cues from cell communication cards. Students mimic signaling pathways by running in place, interacting with specific classmates by either bumping into them or holding them, and leaning or lifting arms to simulate conformational changes.The Science Practice Challenge Questions contain additional test questions for this section that will help you prepare for the AP exam. These questions address the following standards:
[APLO 3.33][APLO 3.35]Inside the cell, ligands bind to their internal receptors, allowing them to directly affect the cell’s DNA and protein-producing machinery. Using signal transduction pathways, receptors in the plasma membrane produce a variety of effects on the cell. The results of signaling pathways are extremely varied and depend on the type of cell involved as well as the external and internal conditions. A small sampling of responses is described below.
@@ -137,7 +137,7 @@
Cancer BiologistCancer biologists study the molecular origins of cancer with the goal of developing new prevention methods and treatment strategies that will inhibit the growth of tumors without harming the normal cells of the body. As mentioned earlier, signaling pathways control cell growth. These signaling pathways are controlled by signaling proteins, which are, in turn, expressed by genes. Mutations in these genes can result in malfunctioning signaling proteins. This prevents the cell from regulating its cell cycle, triggering unrestricted cell division and cancer. The genes that regulate the signaling proteins are one type of oncogene, which is a gene that has the potential to cause cancer. The gene encoding RAS is an oncogene that was originally discovered when mutations in the RAS protein were linked to cancer. Further studies have indicated that 30 percent of cancer cells have a mutation in the RAS gene that leads to uncontrolled growth. If left unchecked, uncontrolled cell division can lead to tumor formation and metastasis, the growth of cancer cells in new locations in the body.Cancer biologists have been able to identify many other oncogenes that contribute to the development of cancer. For example, HER2 is a cell-surface receptor that is present in excessive amounts in 20 percent of human breast cancers. Cancer biologists realized that gene duplication led to HER2 overexpression in 25 percent of breast cancer patients and developed a drug called Herceptin (trastuzumab). Herceptin is a monoclonal antibody that targets HER2 for removal by the immune system. Herceptin therapy helps to control signaling through HER2. The use of Herceptin in combination with chemotherapy has helped to increase the overall survival rate of patients with metastatic breast cancer.
-More information on cancer biology research can be found at the National Cancer Institute website.
+More information on cancer biology research can be found at the National Cancer Institute website.Cell DeathWhen a cell is damaged, superfluous, or potentially dangerous to an organism, a cell can initiate a mechanism to trigger programmed cell death, or apoptosis. Apoptosis allows a cell to die in a controlled manner that prevents the release of potentially damaging molecules from inside the cell. There are many internal checkpoints that monitor a cell’s health; if abnormalities are observed, a cell can spontaneously initiate the process of apoptosis. However, in some cases, such as a viral infection or uncontrolled cell division, the cell’s normal checks and balances fail. External signaling can also initiate apoptosis. For example, most normal animal cells have receptors that interact with the extracellular matrix, a network of glycoproteins that provides structural support for cells in an organism. The binding of cellular receptors to the extracellular matrix initiates a signaling cascade within the cell. However, if the cell moves away from the extracellular matrix, the signaling ceases, and the cell undergoes apoptosis. This system keeps cells from traveling through the body and proliferating out of control.
diff --git a/modules/m62801/index.cnxml b/modules/m62801/index.cnxml
index 960e9da40..a8cfea31b 100644
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@@ -75,9 +75,9 @@
Unicellular organisms were assumed to communicate at a very primitive level, but current research reveals the existence more complex signaling systems. Examples of these forms of communication are the formation of biofilms and quorum sensing. Biofilms have received the attention of researchers only recently for several historical and technical reasons. Since the germ theory of disease was established, the interest had been to isolate and characterize pathogens, not to study microorganisms as a community.It is much easier to grow bacteria as pure cultures than replicate mixed populations biofilms, making the latter difficult to study in the laboratory setting. Such slime layers, previously considered haphazard assemblies of microorganisms, have been found to be highly organized ecosystems. The slime layer is made of extracellular polymers crisscrossed with channels for gases, nutrients, waste exchanges. Microbes attach to the solid substrate in a succession of populations.
-Quorum sensing exists both within a same species and across species. It allows microbes to behave as multicellular populations and coordinate responses. One such example is the expression of genes encoding toxins in Staphylococcus aureus. Dr. Bonnie Bassler presents quorum sensing communication in Vibrio harveyi in this Ted Talk. Her enthusiasm and clear explanations make this video a thoroughly engaging experience. This is an opportunity to show a strong female role model in science.
-Also available is this video clip: Quorum sensing molecules presented by Dr. Bonnie Bassler:
-And an animation on quorum sensing in Vibrio harveyi can be found here.
+Quorum sensing exists both within a same species and across species. It allows microbes to behave as multicellular populations and coordinate responses. One such example is the expression of genes encoding toxins in Staphylococcus aureus. Dr. Bonnie Bassler presents quorum sensing communication in Vibrio harveyi in this Ted Talk. Her enthusiasm and clear explanations make this video a thoroughly engaging experience. This is an opportunity to show a strong female role model in science.
+Also available is this video clip: Quorum sensing molecules presented by Dr. Bonnie Bassler:
+And an animation on quorum sensing in Vibrio harveyi can be found here.Further reading: Painter, Kimberley L. et al. (2014). What role does the quorum-sensing accessory gene regulator system play during Staphylococcus aureus bacteremia? Trends in Microbiology 22:676–685
@@ -138,7 +138,7 @@ Presumably, unicellular organisms do not need to coordinate the response of many
Research on the details of quorum sensing has led to advances in growing bacteria for industrial purposes. Recent discoveries suggest that it may be possible to exploit bacterial signaling pathways to control bacterial growth; this process could replace or supplement antibiotics that are no longer effective in certain situations.
-Watch geneticist Bonnie Bassler discuss her discovery of quorum sensing in biofilm bacteria in squid.
+Watch geneticist Bonnie Bassler discuss her discovery of quorum sensing in biofilm bacteria in squid.
@@ -160,7 +160,7 @@ Presumably, unicellular organisms do not need to coordinate the response of many
-Watch this collection of interview clips with biofilm researchers in “What Are Bacterial Biofilms?”
+Watch this collection of interview clips with biofilm researchers in “What Are Bacterial Biofilms?”
diff --git a/modules/m62802/index.cnxml b/modules/m62802/index.cnxml
index 31f389813..cb155b188 100644
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@@ -15,7 +15,7 @@
A sea urchin begins life as a single cell that (a) divides to form two cells, visible by scanning electron microscopy. After four rounds of cell division, (b) there are 16 cells, as seen in this SEM image. After many rounds of cell division, the individual develops into a complex, multicellular organism, as seen in this (c) mature sea urchin. (credit a: modification of work by Evelyn Spiegel, Louisa Howard; credit b: modification of work by Evelyn Spiegel, Louisa Howard; credit c: modification of work by Marco Busdraghi; scale-bar data from Matt Russell)
A human, as well as every sexually reproducing organism, begins life as a fertilized egg (embryo) or zygote. Trillions of cell divisions subsequently occur in a controlled manner to produce a complex, multicellular human. In other words, that original single cell is the ancestor of every other cell in the body. Once a being is fully grown, cell reproduction is still necessary to repair or regenerate tissues. For example, new blood and skin cells are constantly being produced. All multicellular organisms use cell division for growth, maintenance, and repair of tissues. Cell division is tightly regulated, and the occasional failure of regulation can have life-threatening consequences. Single-celled organisms use cell division as their method of reproduction.Not all cells in the body reproduce to repair tissues. Most nerve tissues, for example, are not capable of regeneration. This means people who have damaged their nerves or nervous system are often left paralyzed.
-However, this may change in the future; scientists have discovered a new drug called intracellular signal peptide (ISP), which helps nerve cells regenerate in rats. It works by blocking an enzyme that causes scar tissue in damaged nerve cells allowing the nervous system a chance to repair itself. The full research study is located here.
+However, this may change in the future; scientists have discovered a new drug called intracellular signal peptide (ISP), which helps nerve cells regenerate in rats. It works by blocking an enzyme that causes scar tissue in damaged nerve cells allowing the nervous system a chance to repair itself. The full research study is located here.Before students begin this chapter, it is useful to review these concepts: the differences between prokaryotes and eukaryotes; cell structure; cell signaling; cell growth and cell death.
diff --git a/modules/m62803/index.cnxml b/modules/m62803/index.cnxml
index 7b7e300fd..4c1341038 100644
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@@ -75,7 +75,7 @@
Double-stranded DNA wraps around histone proteins to form nucleosomes that have the appearance of “beads on a string.” The nucleosomes are coiled into a 30-nm chromatin fiber. When a cell undergoes mitosis, the chromosomes condense even further.
DNA replicates in the S phase of interphase. After replication, the chromosomes are composed of two linked sister chromatids. When fully compact, the pairs of identically packed chromosomes are bound to each other by cohesin proteins. The connection between the sister chromatids is closest in a region called the centromere. The conjoined sister chromatids, with a diameter of about 1 µm, are visible under a light microscope. The centromeric region is highly condensed and thus will appear as a constricted area.
-This animation illustrates the different levels of chromosome packing.
+This animation illustrates the different levels of chromosome packing.
diff --git a/modules/m62804/index.cnxml b/modules/m62804/index.cnxml
index 9e8917e54..3b015517c 100644
--- a/modules/m62804/index.cnxml
+++ b/modules/m62804/index.cnxml
@@ -94,12 +94,12 @@
-Discuss with students how in mitosis, the ploidy of the cell remains constant. In a cell culture of human somatic cells, all of the cells will be diploid. In contrast the DNA content, the amount of DNA in a cell culture will change as the cells replicate (undergo S-phase and replicate their DNA). In relative amounts, the initial amount of DNA is considered to be 1x, after S-phase it will be 2x, and so on. More information on the methods used by scientists to track ploidy can be found here.
-Introduce mitosis using visuals such as this video.
-Show Crash Course or Bozeman Videos such as “Cell Cycle, Mitosis & Meiosis”, “Development: Timing & Coordination”, “Mechanisms of Timing & Control”, “DNA, Hot Pockets, & The Longest Word Ever: Crash Course Biology #11”, and “HHMI: Mix 1”
+Discuss with students how in mitosis, the ploidy of the cell remains constant. In a cell culture of human somatic cells, all of the cells will be diploid. In contrast the DNA content, the amount of DNA in a cell culture will change as the cells replicate (undergo S-phase and replicate their DNA). In relative amounts, the initial amount of DNA is considered to be 1x, after S-phase it will be 2x, and so on. More information on the methods used by scientists to track ploidy can be found here.
+Introduce mitosis using visuals such as this video.
+Show Crash Course or Bozeman Videos such as “Cell Cycle, Mitosis & Meiosis”, “Development: Timing & Coordination”, “Mechanisms of Timing & Control”, “DNA, Hot Pockets, & The Longest Word Ever: Crash Course Biology #11”, and “HHMI: Mix 1”Students may think that interphase is a resting phase, where no events occur. Remind students that cells are metabolically active in this phase. Cells in G0 phase are not actively preparing to divide. The cell is in a quiescent (inactive) stage that occurs when cells exit the cell cycle. Some cells enter G0 temporarily until an external signal triggers the onset of G1. Other cells that never or rarely divide, such as mature cardiac muscle and nerve cells, remain in G0 permanently.
-In addition, students may not realize that the events of mitosis are continuous, and the organization into discrete stages is for convenience. Show students a time lapse video to illustrate this, such as found here.The stages of the cell cycle can be taught using the images available here.
+In addition, students may not realize that the events of mitosis are continuous, and the organization into discrete stages is for convenience. Show students a time lapse video to illustrate this, such as found here.The stages of the cell cycle can be taught using the images available here.The Science Practice Challenge Questions contain additional test questions for this section that will help you prepare for the AP exam. These questions address the following standards:
@@ -128,7 +128,7 @@
The Mitotic PhaseThe mitotic phase is a multistep process during which the duplicated chromosomes are aligned, separated, and move into two new, identical daughter cells. The first portion of the mitotic phase is called karyokinesis, or nuclear division. The second portion of the mitotic phase, called cytokinesis, is the physical separation of the cytoplasmic components into the two daughter cells.
-Revisit the stages of mitosis at this site.
+Revisit the stages of mitosis at this site.
@@ -285,7 +285,7 @@
The first activity is an application of Learning Objective 3.8 and Science Practice 1.2 because students are modelling steps of the cell cycle, including mitosis and meiosis. A variety of materials can be used to represent chromosomes in the model as long as the students can easily distinguish between the three chromosomes (such as by having different-sized pipe cleaners) as well as distinguish between homologs (such as by using two colors of pipe cleaner). Be sure to provide enough chromosomes to represent sister chromatids in both the mitosis and meiosis models. The critical point to stress is that, in modelling mitosis, students should place homologous chromosomes (each with a sister chromatid) above and below each other during metaphase, ensuring a sister chromosome from each homolog enters each daughter cell. Conversely, in metaphase I of meiosis, the homologous chromosomes (each with a sister chromatid) will pair together side-by-side so that each cell only receives one of the two homologs.The second activity is an application of Learning Objective 3.11 and Science Practice 5.3 because students are using their knowledge of meiosis to explain and predict possible ploidy levels in crop plants. Students should work in pairs or as a group.
-An expanded lab investigation for mitosis and meiosis, involving studying onion cells undergoing mitosis (part 2), and karyotype analysis (part 3) is available from the College Board’s®AP Biology Investigative Labs: An Inquiry-Based Approach in Investigation 7.
+An expanded lab investigation for mitosis and meiosis, involving studying onion cells undergoing mitosis (part 2), and karyotype analysis (part 3) is available from the College Board’s®AP Biology Investigative Labs: An Inquiry-Based Approach in Investigation 7.Possible AnswerThe multiploid count is always a whole-number multiple of the normal chromosome count.
diff --git a/modules/m62805/index.cnxml b/modules/m62805/index.cnxml
index 06328c49f..238eeaed9 100644
--- a/modules/m62805/index.cnxml
+++ b/modules/m62805/index.cnxml
@@ -70,7 +70,7 @@
-Introduce the topic of control of the cell cycle using visuals such as this video.
+Introduce the topic of control of the cell cycle using visuals such as this video.The length of the cell cycle is highly variable, even within the cells of a single organism. In humans, the frequency of cell turnover ranges from a few hours in early embryonic development, to an average of two to five days for epithelial cells, and to an entire human lifetime spent in G0 by specialized cells, such as cortical neurons or cardiac muscle cells. There is also variation in the time that a cell spends in each phase of the cell cycle. When fast-dividing mammalian cells are grown in culture (outside the body under optimal growing conditions), the length of the cycle is about 24 hours. In rapidly dividing human cells with a 24-hour cell cycle, the G1 phase lasts approximately nine hours, the S phase lasts 10 hours, the G2 phase lasts about four and one-half hours, and the M phase lasts approximately one-half hour. In early embryos of fruit flies, the cell cycle is completed in about eight minutes. The timing of events in the cell cycle is controlled by mechanisms that are both internal and external to the cell.
@@ -96,7 +96,7 @@
The M CheckpointThe M checkpoint occurs near the end of the metaphase stage of karyokinesis. The M checkpoint is also known as the spindle checkpoint, because it determines whether all the sister chromatids are correctly attached to the spindle microtubules. Because the separation of the sister chromatids during anaphase is an irreversible step, the cycle will not proceed until the kinetochores of each pair of sister chromatids are firmly anchored to at least two spindle fibers arising from opposite poles of the cell.
-Watch what occurs at the G1, G2, and M checkpoints by visiting this website to see an animation of the cell cycle.
+Watch what occurs at the G1, G2, and M checkpoints by visiting this website to see an animation of the cell cycle.
diff --git a/modules/m62806/index.cnxml b/modules/m62806/index.cnxml
index 7ddfea7a8..2df7f6c26 100644
--- a/modules/m62806/index.cnxml
+++ b/modules/m62806/index.cnxml
@@ -52,11 +52,11 @@
-This chapter reviews the fidelity with which undamaged and damaged DNA is copied. Students who want more background on how gene mutations can occur maybe interested in reading the review “The fidelity of DNA synthesis by eukaryotic replicative and translation synthesis polymerases” here.
-Introduce the topic of loss of control of the cell cycle using visuals such as these videos: “The Eukaryotic Cell Cycle and Cancer”, “Tumor Suppressor Genes”, “Click and Learn: p53 Gene and Cancer”, and “Using p53 to Fight Cancer”.
+This chapter reviews the fidelity with which undamaged and damaged DNA is copied. Students who want more background on how gene mutations can occur maybe interested in reading the review “The fidelity of DNA synthesis by eukaryotic replicative and translation synthesis polymerases” here.
+Introduce the topic of loss of control of the cell cycle using visuals such as these videos: “The Eukaryotic Cell Cycle and Cancer”, “Tumor Suppressor Genes”, “Click and Learn: p53 Gene and Cancer”, and “Using p53 to Fight Cancer”.
-Students may believe that the presence of a mutation in p53 or any of the tumor suppressor genes or proto-oncogenes leads to the formation of cancer in every case. However, the development of cancer is a complex process. The presence of a gene mutation does not in and of itself mean cancer will develop. Three main factors can cause cancer: environmental factors, carcinogens, viruses, and genetics. Additional overview of the development of cancer can be given to students in this video.
+Students may believe that the presence of a mutation in p53 or any of the tumor suppressor genes or proto-oncogenes leads to the formation of cancer in every case. However, the development of cancer is a complex process. The presence of a gene mutation does not in and of itself mean cancer will develop. Three main factors can cause cancer: environmental factors, carcinogens, viruses, and genetics. Additional overview of the development of cancer can be given to students in this video.The Science Practice Challenge Questions contain additional test questions for this section that will help you prepare for the AP exam. These questions address the following standards:
[APLO 2.32][APLO 2.34][APLO 3.6][APLO 3.7][APLO 3.8][APLO 4.6][APLO 4.14][APLO 4.22]Cancer comprises many different diseases caused by a common mechanism: uncontrolled cell growth. Despite the redundancy and overlapping levels of cell cycle control, errors do occur. One of the critical processes monitored by the cell cycle checkpoint surveillance mechanism is the proper replication of DNA during the S phase. Even when all of the cell cycle controls are fully functional, a small percentage of replication errors (mutations) will be passed on to the daughter cells. If changes to the DNA nucleotide sequence occur within a coding portion of a gene and are not corrected, a gene mutation results. All cancers start when a gene mutation gives rise to a faulty protein that plays a key role in cell reproduction. The change in the cell that results from the malformed protein may be minor: perhaps a slight delay in the binding of Cdk to cyclin or an Rb protein that detaches from its target DNA while still phosphorylated. Even minor mistakes, however, may allow subsequent mistakes to occur more readily. Over and over, small uncorrected errors are passed from the parent cell to the daughter cells and amplified as each generation produces more non-functional proteins from uncorrected DNA damage. Eventually, the pace of the cell cycle speeds up as the effectiveness of the control and repair mechanisms decreases. Uncontrolled growth of the mutated cells outpaces the growth of normal cells in the area, and a tumor (“-oma”) can result.
@@ -83,7 +83,7 @@ will deem the cell unsalvageable and trigger programmed cell death (apoptosis).
The loss of p53 function has other repercussions for the cell cycle. Mutated p53 might lose its ability to trigger p21 production. Without adequate levels of p21, there is no effective block on Cdk activation. Essentially, without a fully functional p53, the G1 checkpoint is severely compromised and the cell proceeds directly from G1 to S regardless of internal and external conditions. At the completion of this shortened cell cycle, two daughter cells are produced that have inherited the mutated p53 gene. Given the non-optimal conditions under which the parent cell reproduced, it is likely that the daughter cells will have acquired other mutations in addition to the faulty tumor suppressor gene. Cells such as these daughter cells quickly accumulate both oncogenes and non-functional tumor suppressor genes. Again, the result is tumor growth.
-Go to this website to watch an animation of how cancer results from errors in the cell cycle.
+Go to this website to watch an animation of how cancer results from errors in the cell cycle.
diff --git a/modules/m62809/index.cnxml b/modules/m62809/index.cnxml
index 29bed9090..fa5156dae 100644
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@@ -16,7 +16,7 @@
The ability to reproduce “in kind” is a basic characteristic of all living things. “In kind” means that the offspring of an organism closely resembles its parent or parents. Hippopotamuses give birth to hippopotamus calves, Joshua trees produce Joshua tree seedlings, and flamingos lay eggs that hatch into flamingo chicks. In kind can mean exactly the same. Many unicellular organisms, such as yeast, and a few multicellular organisms, such as sponges, can produce genetically identical clones of themselves through cell division. However, many single-celled organisms and most multicellular organisms reproduce regularly using a method requiring two parents. Sexual reproduction occurs through the production by each parent of a haploid cell (containing one half of an offspring’s required genetic material) and the fusion of these two haploid cells to form a single, unique diploid cell with a complete set of genetic information. In most plants and animals, through multiple rounds of mitotic cell division, this diploid cell will develop into an adult organism. Haploid cells that are necessary for sexual reproduction are produced by a type of cell division called meiosis. Sexual reproduction, specifically meiosis and fertilization, introduces variation into offspring. Variation is an important component of a species evolutionary success. The vast majority of eukaryotic organisms employs some form of meiosis and fertilization to reproduce.
-Not all sexually reproducing eukaryotes reproduce solely by sexual reproduction. For example, an Asian termite species, Reticulitermes speratus, can reproduce sexually or asexually. In a young colony, a single termite pair—the king and queen—produce worker offspring sexually by the union of haploid cells. However, after several years, as the queen begins to age, she produces some offspring asexually in a process called parthenogenesis. These offspring, which are destined to become new queens, are not fertilized by the king. They are genetic clones of the queen. More information about parthenogenesis in these termites can be found at this article.
+Not all sexually reproducing eukaryotes reproduce solely by sexual reproduction. For example, an Asian termite species, Reticulitermes speratus, can reproduce sexually or asexually. In a young colony, a single termite pair—the king and queen—produce worker offspring sexually by the union of haploid cells. However, after several years, as the queen begins to age, she produces some offspring asexually in a process called parthenogenesis. These offspring, which are destined to become new queens, are not fertilized by the king. They are genetic clones of the queen. More information about parthenogenesis in these termites can be found at this article.It is important to stress how critical sexual reproduction is for the adaptation and survival of many species. Natural selection works only because there are variations in genes, and genetic variations are a natural result of sexual reproduction.
diff --git a/modules/m62810/index.cnxml b/modules/m62810/index.cnxml
index ad77cff97..5f2d0ac36 100644
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@@ -138,7 +138,7 @@
Two haploid cells are the end result of the first meiotic division. The cells are haploid because at each pole, there is just one of each pair of the homologous chromosomes. Therefore, only one full set of the chromosomes is present. This is why the cells are considered haploid—there is only one chromosome set, even though each homolog still consists of two sister chromatids. Recall that sister chromatids are merely duplicates of one of the two homologous chromosomes (except for changes that occurred during crossing over). In meiosis II, these two sister chromatids will separate, creating four haploid daughter cells.
-Review the process of meiosis, observing how chromosomes align and migrate, at Meiosis: An Interactive Animation.
+Review the process of meiosis, observing how chromosomes align and migrate, at Meiosis: An Interactive Animation.
@@ -200,7 +200,7 @@
-Click through the steps of this interactive animation to compare the meiotic process of cell division to that of mitosis: How Cells Divide.
+Click through the steps of this interactive animation to compare the meiotic process of cell division to that of mitosis: How Cells Divide.
diff --git a/modules/m62812/index.cnxml b/modules/m62812/index.cnxml
index 67bc65a6b..3c783ea8d 100644
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@@ -15,7 +15,7 @@
Experimenting with thousands of garden peas, Mendel uncovered the fundamentals of genetics. (credit: modification of work by Jerry Kirkhart)
During the 19th century, long before chromosomes or genes had been identified, Johann Gregor Mendel set the framework for genetics by studying a simple biological system, the garden pea. He conducted methodical, quantitative analyses using large sample sizes. Mendel’s work laid the foundation for the fundamental principles of heredity. We now know that genes, carried on chromosomes, are the basic functional units of heredity with the capacity to be replicated, expressed, repressed, modified and mutated. Today, the postulates put forth by Mendel form the basis of classical, or Mendelian, genetics. Genes do not all obey the tenets of Mendelian genetics, but Mendel’s experiments serve as an excellent starting point for thinking about inheritance.
-An understanding of genetic inheritance enables scientists to study and explain complex phenomena. For example, scientists studied the remains of 84 ancient dogs from North and South America. They found that some of the dogs had greater genetic diversity, indicating that these dogs might have interbred with American wolves. Other dogs in their sample had low diversity, indicating that ancient humans were purposely breeding dogs. The study also found that dogs migrated to the Americas with humans only about 10,000 years ago. You can read more about this fascinating story here.
+An understanding of genetic inheritance enables scientists to study and explain complex phenomena. For example, scientists studied the remains of 84 ancient dogs from North and South America. They found that some of the dogs had greater genetic diversity, indicating that these dogs might have interbred with American wolves. Other dogs in their sample had low diversity, indicating that ancient humans were purposely breeding dogs. The study also found that dogs migrated to the Americas with humans only about 10,000 years ago. You can read more about this fascinating story here.Introduce the topic of genetics to the students. Ask them what they think genetics is about. Can it explain why children resemble their parents? This warm up is a good opportunity to assess how familiar students are with the topic, which is very often front page news and usually poorly explained or misunderstood. Present the warm up topic of dogs interbreeding with wolves and the concepts of humans breeding animals and plants. It will be an opportunity to remind students that genetically modified organisms are not a new concept. What is new is the modification of traits at the molecular level.Ask students if they like Brussels sprouts or broccoli. Usually there is a diversity of responses. Some truly hate them while other students will insist that they are very good. Tell them that their genes can contribute to their like or dislike of these vegetables. Ask students to look at their hairlines and compare. The widow’s peak is considered dominant and, for simplification purposes, a monogenic trait.
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index 757255387..ff200fe8f 100644
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@@ -144,7 +144,7 @@
-
Johann Gregor Mendel is considered the father of genetics.
Johann Gregor Mendel (1822–1884) () was a lifelong learner, teacher, scientist, and man of faith. As a young adult, he joined the Augustinian Abbey of St. Thomas in Brno in what is now the Czech Republic. Supported by the monastery, he taught physics, botany, and natural science courses at the secondary and university levels. In 1856, he began a decade-long research pursuit involving inheritance patterns in honeybees and plants, ultimately settling on pea plants as his primary model system (a system with convenient characteristics used to study a specific biological phenomenon to be applied to other systems). In 1865, Mendel presented the results of his experiments with nearly 30,000 pea plants to the local Natural History Society. He demonstrated that traits are transmitted faithfully from parents to offspring independently of other traits and in dominant and recessive patterns. In 1866, he published his work, Experiments in Plant Hybridization,Johann Gregor Mendel, Versuche über Pflanzenhybriden Verhandlungen des naturforschenden Vereines in Brünn, Bd. IV für das Jahr, 1865 Abhandlungen, 3–47. [go here for the English translation here] in the proceedings of the Natural History Society of Brünn.Mendel’s work went virtually unnoticed by the scientific community that believed, incorrectly, that the process of inheritance involved a blending of parental traits that produced an intermediate physical appearance in offspring; this hypothetical process appeared to be correct because of what we know now as continuous variation. Continuous variation results from the action of many genes to determine a characteristic like human height. Offspring appear to be a “blend” of their parents’ traits when we look at characteristics that exhibit continuous variation. The blending theory of inheritance asserted that the original parental traits were lost or absorbed by the blending in the offspring, but we now know that this is not the case. Mendel was the first researcher to see it. Instead of continuous characteristics, Mendel worked with traits that were inherited in distinct classes (specifically, violet versus white flowers); this is referred to as discontinuous variation. Mendel’s choice of these kinds of traits allowed him to see experimentally that the traits were not blended in the offspring, nor were they absorbed, but rather that they kept their distinctness and could be passed on. In 1868, Mendel became abbot of the monastery and exchanged his scientific pursuits for his pastoral duties. He was not recognized for his extraordinary scientific contributions during his lifetime. In fact, it was not until 1900 that his work was rediscovered, reproduced, and revitalized by scientists on the brink of discovering the chromosomal basis of heredity.
+
Johann Gregor Mendel is considered the father of genetics.
Johann Gregor Mendel (1822–1884) () was a lifelong learner, teacher, scientist, and man of faith. As a young adult, he joined the Augustinian Abbey of St. Thomas in Brno in what is now the Czech Republic. Supported by the monastery, he taught physics, botany, and natural science courses at the secondary and university levels. In 1856, he began a decade-long research pursuit involving inheritance patterns in honeybees and plants, ultimately settling on pea plants as his primary model system (a system with convenient characteristics used to study a specific biological phenomenon to be applied to other systems). In 1865, Mendel presented the results of his experiments with nearly 30,000 pea plants to the local Natural History Society. He demonstrated that traits are transmitted faithfully from parents to offspring independently of other traits and in dominant and recessive patterns. In 1866, he published his work, Experiments in Plant Hybridization,Johann Gregor Mendel, Versuche über Pflanzenhybriden Verhandlungen des naturforschenden Vereines in Brünn, Bd. IV für das Jahr, 1865 Abhandlungen, 3–47. [go here for the English translation here] in the proceedings of the Natural History Society of Brünn.Mendel’s work went virtually unnoticed by the scientific community that believed, incorrectly, that the process of inheritance involved a blending of parental traits that produced an intermediate physical appearance in offspring; this hypothetical process appeared to be correct because of what we know now as continuous variation. Continuous variation results from the action of many genes to determine a characteristic like human height. Offspring appear to be a “blend” of their parents’ traits when we look at characteristics that exhibit continuous variation. The blending theory of inheritance asserted that the original parental traits were lost or absorbed by the blending in the offspring, but we now know that this is not the case. Mendel was the first researcher to see it. Instead of continuous characteristics, Mendel worked with traits that were inherited in distinct classes (specifically, violet versus white flowers); this is referred to as discontinuous variation. Mendel’s choice of these kinds of traits allowed him to see experimentally that the traits were not blended in the offspring, nor were they absorbed, but rather that they kept their distinctness and could be passed on. In 1868, Mendel became abbot of the monastery and exchanged his scientific pursuits for his pastoral duties. He was not recognized for his extraordinary scientific contributions during his lifetime. In fact, it was not until 1900 that his work was rediscovered, reproduced, and revitalized by scientists on the brink of discovering the chromosomal basis of heredity.Mendel’s Model SystemMendel’s seminal work was accomplished using the garden pea, Pisum sativum, to study inheritance. This species naturally self-fertilizes, such that pollen encounters ova within individual flowers. The flower petals remain sealed tightly until after pollination, preventing pollination from other plants. The result is highly inbred, or “true-breeding,” pea plants. These are plants that always produce offspring that look like the parent. By experimenting with true-breeding pea plants, Mendel avoided the appearance of unexpected traits in offspring that might occur if the plants were not true breeding. The garden pea also grows to maturity within one season, meaning that several generations could be evaluated over a relatively short time. Finally, large quantities of garden peas could be cultivated simultaneously, allowing Mendel to conclude that his results did not come about simply by chance.
diff --git a/modules/m62817/index.cnxml b/modules/m62817/index.cnxml
index 83ba18d24..538b20ca1 100644
--- a/modules/m62817/index.cnxml
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@@ -160,12 +160,12 @@
-Emphasize to the class the importance of using a Punnett’s square rather than “guessing” the right answer. Students should show their reasoning to solve Mendelian genetics problems. This site contains a wealth of problems. Ask students to answer questions after designing a Punnett’s square.It is recommended to work through all problems and assessments before assigning them to students. Verify that there is only one correct answer or alert students that there might be several correct answers.
+Emphasize to the class the importance of using a Punnett’s square rather than “guessing” the right answer. Students should show their reasoning to solve Mendelian genetics problems. This site contains a wealth of problems. Ask students to answer questions after designing a Punnett’s square.It is recommended to work through all problems and assessments before assigning them to students. Verify that there is only one correct answer or alert students that there might be several correct answers.Choose easily observable traits such as widow’s peak or attached ear lobe. Divide the class into groups of 5—6 students. Each group will draw possible Punnett squares for the traits of students in their group. Because the students can only observe their phenotype, each student may have several possible Punnett squares, depending on his/her parent’s genotypes.Another exercise to be performed by the students is measuring the distribution of tasters and non-tasters of the bitter chemical phenylthiocarbamide (PTC). Paper strips impregnated with PTC are available from scientific suppliers and can be used to survey the class. Ask students to put a strip of paper on their tongue and record the taste. Some individuals can react strongly to an intensely bitter taste, other can detect a bitter taste, and, for some, it is just insipid paper. The ability to taste PTC is controlled by the gene TAS2R38 whose taster allele is dominant over the non-taster allele.
-For more information, go here this site. You may also find worksheets here. For resources on human genetics visit the Online Mendelian Inheritance in Man Online Mendelian Inheritance in Man and the Genetics Home References.
+For more information, go here this site. You may also find worksheets here. For resources on human genetics visit the Online Mendelian Inheritance in Man Online Mendelian Inheritance in Man and the Genetics Home References.
@@ -342,7 +342,7 @@
The son of a woman who is a carrier of a recessive X-linked disorder will have a 50 percent chance of being affected. A daughter will not be affected, but she will have a 50 percent chance of being a carrier like her mother.
- Watch this video to learn more about sex-linked traits.
+ Watch this video to learn more about sex-linked traits.
diff --git a/modules/m62819/index.cnxml b/modules/m62819/index.cnxml
index 0b0863a4a..945b8524a 100644
--- a/modules/m62819/index.cnxml
+++ b/modules/m62819/index.cnxml
@@ -242,7 +242,7 @@
EpistasisMendel’s studies in pea plants implied that the sum of an individual’s phenotype was controlled by genes (or as he called them, unit factors), such that every characteristic was distinctly and completely controlled by a single gene. In fact, single observable characteristics are almost always under the influence of multiple genes (each with two or more alleles) acting in unison. For example, at least eight genes contribute to eye color in humans.
- Eye color in humans is determined by multiple genes. Use the Eye Color Calculator to predict the eye color of children from parental eye color.
+ Eye color in humans is determined by multiple genes. Use the Eye Color Calculator to predict the eye color of children from parental eye color.
diff --git a/modules/m62820/index.cnxml b/modules/m62820/index.cnxml
index 38da1b585..050048171 100644
--- a/modules/m62820/index.cnxml
+++ b/modules/m62820/index.cnxml
@@ -14,7 +14,7 @@
Chromosomes are threadlike nuclear structures consisting of DNA and proteins that serve as the repositories for genetic information. The chromosomes depicted here were isolated from a fruit fly’s salivary gland, stained with dye, and visualized under a microscope. Akin to miniature bar codes, chromosomes absorb different dyes to produce characteristic banding patterns, which allows for their routine identification. (credit: modification of work by “LPLT”/Wikimedia Commons; scale-bar data from Matt Russell)
-According to the United Nations Office on Drugs and Crime, approximately 95% of those who commit homicide are men. While behavior is shaped by the environment one grows up and lives in, genetics also play a role. For example, scientists have discovered genes that appear to increase one’s tendency to exhibit aggressive behavior. One of the genes, called MAOA, is located on the X chromosome. In one recent study involving a group of male prisoners in Finland, scientists found that the prisoners who inherited a variant of this gene were between 5% and 10% more likely to have committed a violent crime. Men only have one copy of the gene, since men only have one X chromosome. Women, however, have two copies of the X chromosome and therefore two copies of the gene. Therefore, women who inherit the variant allele will most likely also have a normal allele to counteract its effects. It is important to note that many men inherit the variant copy of MAOA and only some commit violent crimes. The environment seems to play a much more critical role. You can read more about nature/nurture roles in crime in this article.
+According to the United Nations Office on Drugs and Crime, approximately 95% of those who commit homicide are men. While behavior is shaped by the environment one grows up and lives in, genetics also play a role. For example, scientists have discovered genes that appear to increase one’s tendency to exhibit aggressive behavior. One of the genes, called MAOA, is located on the X chromosome. In one recent study involving a group of male prisoners in Finland, scientists found that the prisoners who inherited a variant of this gene were between 5% and 10% more likely to have committed a violent crime. Men only have one copy of the gene, since men only have one X chromosome. Women, however, have two copies of the X chromosome and therefore two copies of the gene. Therefore, women who inherit the variant allele will most likely also have a normal allele to counteract its effects. It is important to note that many men inherit the variant copy of MAOA and only some commit violent crimes. The environment seems to play a much more critical role. You can read more about nature/nurture roles in crime in this article. Before students begin this chapter, it is useful to review these concepts: DNA and chromosome structure; relationships among DNA, genes, and chromosomes; overview of the steps of mitosis and meiosis; overview of independent assortment; ploidy (haploid versus diploid).
diff --git a/modules/m62821/index.cnxml b/modules/m62821/index.cnxml
index daf14e565..8ba9bb416 100644
--- a/modules/m62821/index.cnxml
+++ b/modules/m62821/index.cnxml
@@ -74,9 +74,9 @@
-Introduce genetic linkage using visuals such as this video.
-Students can read about linked genes and Mendel’s work in this article.
-Have students work through inheritance scenarios where genes are linked and where they are on different chromosomes using the following activity sheet.Teacher preparation notes for this activity are available here.
+Introduce genetic linkage using visuals such as this video.
+Students can read about linked genes and Mendel’s work in this article.
+Have students work through inheritance scenarios where genes are linked and where they are on different chromosomes using the following activity sheet.Teacher preparation notes for this activity are available here.The Science Practice Challenge Questions contain additional test questions for this section that will help you prepare for the AP exam. These questions address the following standards:
[APLO 3.2][APLO 3.11][APLO 3.14][APLO 3.15][APLO 3.28][APLO 3.26][APLO 3.17][APLO 4.22]Long before chromosomes were visualized under a microscope, the father of modern genetics, Gregor Mendel, began studying heredity in 1843. With the improvement of microscopic techniques during the late 1800s, cell biologists could stain and visualize subcellular structures with dyes and observe their actions during cell division and meiosis. With each mitotic division, chromosomes replicated, condensed from an amorphous (no constant shape) nuclear mass into distinct X-shaped bodies (pairs of identical sister chromatids), and migrated to separate cellular poles.
@@ -132,7 +132,7 @@
AnswerMore parental type offspring are produced because the genes that are being examined in the dihybrid cross are linked. Genes whose loci are nearer to each other are less likely to be separated onto different chromatids during meiosis as a result of chromosomal crossover. Therefore, there will be more offspring with the parental phenotype than the recombinant phenotype.More information about linked genes can be found at the following resources:
-Linked genes: Youtube videoChromosomal inheritance: Youtube video
+Linked genes: Youtube videoChromosomal inheritance: Youtube videoGenetic Markers for CancersScientists have used genetic linkage to discover the location in the human genome of many genes that cause disease. They locate disease genes by tracking inheritance of traits through generations of families and creating linkage maps that measure recombination among groups of genetic “markers.” The two BRCA genes, mutations which can lead to breast and ovarian cancers, were some of the first genes discovered by genetic mapping. Women who have family histories of these cancers can now be screened to determine if one or both of these genes carry a mutation. If so, they can opt to have their breasts and ovaries surgically removed. This decreases their chances of getting cancer later in life. The actress Angelia Jolie brought this to the public’s attention when she opted for surgery in 2014 and again in 2015 after doctors found she carried a mutated BRCA1 gene.
@@ -162,7 +162,7 @@
As shown in , by using recombination frequency to predict genetic distance, the relative order of genes on chromosome 2 could be inferred. The values shown represent map distances in centimorgans (cM), which correspond to recombination frequencies (in percent). Therefore, the genes for body color and wing size were 65.5 − 48.5 = 17 cM apart, indicating that the maternal and paternal alleles for these genes recombine in 17 percent of offspring, on average.To construct a chromosome map, Sturtevant assumed that genes were ordered serially on threadlike chromosomes. He also assumed that the incidence of recombination between two homologous chromosomes could occur with equal likelihood anywhere along the length of the chromosome. Operating under these assumptions, Sturtevant postulated that alleles that were far apart on a chromosome were more likely to dissociate during meiosis simply because there was a larger region over which recombination could occur. Conversely, alleles that were close to each other on the chromosome were likely to be inherited together. The average number of crossovers between two alleles—that is, their recombination frequency—correlated with their genetic distance from each other, relative to the locations of other genes on that chromosome. Considering the example cross between AaBb and aabb above, the frequency of recombination could be calculated as 50/1000 = 0.05. That is, the likelihood of a crossover between genes A/a and B/b was 0.05, or 5 percent. Such a result would indicate that the genes were definitively linked, but that they were far enough apart for crossovers to occasionally occur. Sturtevant divided his genetic map into map units, or centimorgans (cM), in which a recombination frequency of 0.01 corresponds to 1 cM.By representing alleles in a linear map, Sturtevant suggested that genes can range from being perfectly linked (recombination frequency = 0) to being perfectly unlinked (recombination frequency = 0.5) when genes are on different chromosomes or genes are separated very far apart on the same chromosome. Perfectly unlinked genes correspond to the frequencies predicted by Mendel to assort independently in a dihybrid cross. A recombination frequency of 0.5 indicates that 50 percent of offspring are recombinants and the other 50 percent are parental types. That is, every type of allele combination is represented with equal frequency. This representation allowed Sturtevant to additively calculate distances between several genes on the same chromosome. However, as the genetic distances approached 0.50, his predictions became less accurate because it was not clear whether the genes were very far apart on the same chromosome or on different chromosomes.In 1931, Barbara McClintock and Harriet Creighton demonstrated the crossover of homologous chromosomes in corn plants. Weeks later, homologous recombination in Drosophila was demonstrated microscopically by Curt Stern. Stern observed several X-linked phenotypes that were associated with a structurally unusual and dissimilar X chromosome pair in which one X was missing a small terminal segment, and the other X was fused to a piece of the Y chromosome. By crossing flies, observing their offspring, and then visualizing the offspring’s chromosomes, Stern demonstrated that every time the offspring allele combination deviated from either of the parental combinations, there was a corresponding exchange of an X chromosome segment. Using mutant flies with structurally distinct X chromosomes was the key to observing the products of recombination because DNA sequencing and other molecular tools were not yet available. It is now known that homologous chromosomes regularly exchange segments in meiosis by reciprocally breaking and rejoining their DNA at precise locations.
-Review Sturtevant’s process to create a genetic map on the basis of recombination frequencies here.
+Review Sturtevant’s process to create a genetic map on the basis of recombination frequencies here.
diff --git a/modules/m62822/index.cnxml b/modules/m62822/index.cnxml
index 5926191d2..91425d446 100644
--- a/modules/m62822/index.cnxml
+++ b/modules/m62822/index.cnxml
@@ -102,9 +102,9 @@
-Introduce karyotyping using this activity, which has students create a karyotype by matching chromosomes, this activity or this activity.Background information on karyotyping is available at this site.
+Introduce karyotyping using this activity, which has students create a karyotype by matching chromosomes, this activity or this activity.Background information on karyotyping is available at this site.
-Some students have difficulties connecting the idea of chromosome structure with inheritance, as discussed in this paper.Students may therefore have trouble understanding the role of chromosomal abnormalities in inherited disorders. It may help students to review meiosis, using videos such as this.
+Some students have difficulties connecting the idea of chromosome structure with inheritance, as discussed in this paper.Students may therefore have trouble understanding the role of chromosomal abnormalities in inherited disorders. It may help students to review meiosis, using videos such as this.Inherited disorders can arise when chromosomes behave abnormally during meiosis. Chromosome disorders can be divided into two categories: abnormalities in chromosome number and chromosomal structural rearrangements. Because even small segments of chromosomes can span many genes, chromosomal disorders are characteristically dramatic and often fatal.
@@ -154,7 +154,7 @@
-Visualize the addition of a chromosome that leads to Down syndrome in this video simulation.
+Visualize the addition of a chromosome that leads to Down syndrome in this video simulation.
diff --git a/modules/m62824/index.cnxml b/modules/m62824/index.cnxml
index 4ec070d48..59de3ad7a 100644
--- a/modules/m62824/index.cnxml
+++ b/modules/m62824/index.cnxml
@@ -120,7 +120,7 @@
Friedrich Miescher (1844–1895) discovered nucleic acids.
-To see Miescher conduct an experiment step-by-step, click through this review of how he discovered the key role of DNA and proteins in the nucleus.
+To see Miescher conduct an experiment step-by-step, click through this review of how he discovered the key role of DNA and proteins in the nucleus.
@@ -164,9 +164,9 @@
The activity is an application of Learning Objective 4.1 and Science Practice 7.1 because students are examining the spatial relationships among the components of a DNA strand and explaining the connections between the sequence and subcomponents of the nucleotides.
-An expanded lab investigation for DNA, involving restriction enzyme analysis, is available from the College Board's® AP Biology Investigative Labs: An Inquiry-Based Approach in Investigation 9.
+An expanded lab investigation for DNA, involving restriction enzyme analysis, is available from the College Board's® AP Biology Investigative Labs: An Inquiry-Based Approach in Investigation 9.
-1) Group size is dependent on the availability of molecular model kits. Please note that extra carbon and hydrogen bonds are likely needed for students to make all 4 nucleotides. Groups could also be assigned to make one of the two pairs of nucleotides, after which the groups can combine the molecules into DNA in step 3. Jmol is available for download here.
+1) Group size is dependent on the availability of molecular model kits. Please note that extra carbon and hydrogen bonds are likely needed for students to make all 4 nucleotides. Groups could also be assigned to make one of the two pairs of nucleotides, after which the groups can combine the molecules into DNA in step 3. Jmol is available for download here.2) Note: some molecular model kits have special bonds to use for hydrogen bonds. If these bonds are not used, the students may not be able to connect the nucleotides together. Sample answer: One notable difference is that thymine and adenine bond with two hydrogen bonds while cytosine and guanine bond using three hydrogen bonds.3) To bond two nucleotides along the sugar-phosphate backbone of DNA, we removed one H from carbon 3 of deoxyribose. We then bonded carbon 3 to one of the single-bonded O atoms on the phosphate ion. Next, we removed the OH group from the CH2 group on the deoxyribose. The carbon on this CH2 group was then bonded to the other single-bonded O on the phosphate ion.The Think About It question is an application of Learning Objective 3.2 and Science Practice 4.1 because students are asked to justify that the Hershey-Chase experiments supported the identification of DNA as the carrier of genetic information. It is also an application of Learning Objective 3.1 and Science Practice 6.5 because students will evaluate researchers’ claims that DNA is found in cells and is the primary source of heritable information.
diff --git a/modules/m62825/index.cnxml b/modules/m62825/index.cnxml
index c228d45c3..33bfc8604 100644
--- a/modules/m62825/index.cnxml
+++ b/modules/m62825/index.cnxml
@@ -95,7 +95,7 @@
-Franklin’s X-ray diffraction pictures helped lead to the discovery of the structure of DNA, but Watson and Crick did not mention Franklin in their seminal 1953 paper, which can be found here. This paper includes annotations that help place the work in historical context. Students might be interested to learn how Watson and Crick discovered the structure of DNA. Details can be found at this PBS website. If possible, find a copy of the announcement of the discovery as it appeared in The New York Times. The wording is interesting and the significance of the discovery is understated.
+Franklin’s X-ray diffraction pictures helped lead to the discovery of the structure of DNA, but Watson and Crick did not mention Franklin in their seminal 1953 paper, which can be found here. This paper includes annotations that help place the work in historical context. Students might be interested to learn how Watson and Crick discovered the structure of DNA. Details can be found at this PBS website. If possible, find a copy of the announcement of the discovery as it appeared in The New York Times. The wording is interesting and the significance of the discovery is understated.The Science Practice Challenge Questions contain additional test questions for this section that will help you prepare for the AP exam. These questions address the following standards:
[APLO 3.3][APLO 3.5][APLO 3.13]The building blocks of DNA are nucleotides. The important components of the nucleotide are a nitrogenous base, deoxyribose (5-carbon sugar), and a phosphate group (). The nucleotide is named depending on the nitrogenous base. The nitrogenous base can be a purine such as adenine (A) and guanine (G), or a pyrimidine such as cytosine (C) and thymine (T).
@@ -136,7 +136,7 @@
Possible answer: PCR allows us to make many copies of DNA for research or other applications. PCR involves separating out the two strands of DNA and adding nucleotides to the specific regions one wishes to amplify. Attaching nucleotide primers allows one to create many copies of only the desired sequences of the DNA. The ability to separate DNA and amplify select regions depends on the knowledge of nucleotide bonding within the DNA molecule described in the Watson and Crick model.DNA Sequencing TechniquesUntil the 1990s, the sequencing of DNA (reading the sequence of DNA) was a relatively expensive and long process. Using radiolabeled nucleotides also compounded the problem through safety concerns. With currently available technology and automated machines, the process is cheap, safer, and can be completed in a matter of hours. Fred Sanger developed the sequencing method used for the human genome sequencing project, which is widely used today ().
-Visit this site to watch a video explaining the DNA sequence reading technique that resulted from Sanger’s work.
+Visit this site to watch a video explaining the DNA sequence reading technique that resulted from Sanger’s work.
@@ -153,7 +153,7 @@
In Frederick Sanger's dideoxy chain termination method, dye-labeled dideoxynucleotides are used to generate DNA fragments that terminate at different points. The DNA is separated by capillary electrophoresis on the basis of size, and from the order of fragments formed, the DNA sequence can be read. The DNA sequence readout is shown on an electropherogram that is generated by a laser scanner.
The DNA sample to be sequenced is denatured or separated into two strands by heating it to high temperatures. The DNA is divided into four tubes in which a primer, DNA polymerase, and all four nucleotides (A, T, G, and C) are added. In addition to each of the four tubes, limited quantities of one of the four dideoxynucleotides are added to each tube respectively. The tubes are labeled as A, T, G, and C according to the ddNTP added. For detection purposes, each of the four dideoxynucleotides carries a different fluorescent label. Chain elongation continues until a fluorescent dideoxy nucleotide is incorporated, after which no further elongation takes place. After the reaction is over, electrophoresis is performed. Even a difference in length of a single base can be detected. The sequence is read from a laser scanner. For his work on DNA sequencing, Sanger received a Nobel Prize in chemistry in 1980.
- Sanger’s genome sequencing has led to a race to sequence human genomes at a rapid speed and low cost, often referred to as the $1000 in one day sequence. Learn more by selecting the Sequencing at Speed animation here.
+ Sanger’s genome sequencing has led to a race to sequence human genomes at a rapid speed and low cost, often referred to as the $1000 in one day sequence. Learn more by selecting the Sequencing at Speed animation here.
@@ -184,7 +184,7 @@
-Watch Svante Pääbo’s talk explaining the Neanderthal genome research at the 2011 annual TED (Technology, Entertainment, Design) conference.
+Watch Svante Pääbo’s talk explaining the Neanderthal genome research at the 2011 annual TED (Technology, Entertainment, Design) conference.
diff --git a/modules/m62826/index.cnxml b/modules/m62826/index.cnxml
index ccf36014a..1adf45616 100644
--- a/modules/m62826/index.cnxml
+++ b/modules/m62826/index.cnxml
@@ -72,7 +72,7 @@
Meselson and Stahl experimented with E. coli grown first in heavy nitrogen (15N) then in 14N. DNA grown in 15N (red band) is heavier than DNA grown in 14N (orange band), and sediments to a lower level in cesium chloride solution in an ultracentrifuge. When DNA grown in 15N is switched to media containing 14N, after one round of cell division the DNA sediments halfway between the 15N and 14N levels, indicating that it now contains fifty percent 14N. In subsequent cell divisions, an increasing amount of DNA contains 14N only. This data supports the semi-conservative replication model. (credit: modification of work by Mariana Ruiz Villareal)
The E. coli culture was then shifted into medium containing 14N and allowed to grow for one generation. The cells were harvested and the DNA was isolated. The DNA was centrifuged at high speeds in an ultracentrifuge. Some cells were allowed to grow for one more life cycle in 14N and spun again. During the density gradient centrifugation, the DNA is loaded into a gradient (typically a salt such as cesium chloride or sucrose) and spun at high speeds of 50,000 to 60,000 rpm. Under these circumstances, the DNA will form a band according to its density in the gradient. DNA grown in 15N will band at a higher density position than that grown in 14N. Meselson and Stahl noted that after one generation of growth in 14N after they had been shifted from 15N, the single band observed was intermediate in position in between DNA of cells grown exclusively in 15N and 14N. This suggested either a semi-conservative or dispersive mode of replication. The DNA harvested from cells grown for two generations in 14N formed two bands: one DNA band was at the intermediate position between 15N and 14N, and the other corresponded to the band of 14N DNA. These results could only be explained if DNA replicates in a semi-conservative manner. Therefore, the other two modes were ruled out.During DNA replication, each of the two strands that make up the double helix serves as a template from which new strands are copied. The new strand will be complementary to the parental or “old” strand. When two daughter DNA copies are formed, they have the same sequence and are divided equally into the two daughter cells.
- Click through this tutorial on DNA replication.
+ Click through this tutorial on DNA replication.
diff --git a/modules/m62828/index.cnxml b/modules/m62828/index.cnxml
index 809770fb6..c05783496 100644
--- a/modules/m62828/index.cnxml
+++ b/modules/m62828/index.cnxml
@@ -110,7 +110,7 @@
- Review the full process of DNA replication here.
+ Review the full process of DNA replication here.
diff --git a/modules/m62833/index.cnxml b/modules/m62833/index.cnxml
index 6d33058bf..80656e962 100644
--- a/modules/m62833/index.cnxml
+++ b/modules/m62833/index.cnxml
@@ -15,10 +15,10 @@
Genes, which are carried on (a) chromosomes, are linearly organized instructions for making the RNA and protein molecules that are necessary for all of processes of life. The (b) interleukin-2 protein and (c) alpha-2u-globulin protein are just two examples of the array of different molecular structures that are encoded by genes. (credit “chromosome: National Human Genome Research Institute; credit “interleukin-2”: Ramin Herati/Created from PDB 1M47 and rendered with Pymol; credit “alpha-2u-globulin”: Darren Logan/rendered with AISMIG)
-The definition of gene has progressed from being an abstract unit of heredity in Mendel’s time to our current concept of a tangible molecular entity capable of replication, expression, and mutation (). Currently, we can perform tests for many genetic diseases, but these tests create ethical and legal issues. For example, would you want to be tested for a debilitating genetic disease if there was the possibility insurance companies could use that information to deny you coverage? Fortunately, the Genetic Information Nondiscrimination Act of 2008 protects American citizens from discrimination from both insurance companies and employers based on genetic information. More information about policy, legal, and ethical issues in genetic research can be found here.
+The definition of gene has progressed from being an abstract unit of heredity in Mendel’s time to our current concept of a tangible molecular entity capable of replication, expression, and mutation (). Currently, we can perform tests for many genetic diseases, but these tests create ethical and legal issues. For example, would you want to be tested for a debilitating genetic disease if there was the possibility insurance companies could use that information to deny you coverage? Fortunately, the Genetic Information Nondiscrimination Act of 2008 protects American citizens from discrimination from both insurance companies and employers based on genetic information. More information about policy, legal, and ethical issues in genetic research can be found here.Introduce students to the Human Genome Project. The project was started in the late 80’s when sequencing was both costly and time consuming. The entire sequence of the human genome was announced in 2003. By then, both the expense and time required for sequencing had dropped considerably. The information can easily be stored and disseminated. As can be expected, with the advent of new technology come moral questions that society must ask.
-Ask students if they would like their genomes to be sequenced. What would they gain by such knowledge? Have them consider who would versus who should have access to that information. Have students balance the benefits of being aware of a predisposition to a certain condition to the risk of having employment or health insurance denied. For some diseases, it is possible with the information on hand to modify one’s lifestyle and increase screening for early detection of the condition. What happens if there are no cures, as is the case for Huntington’s disease? This is the context of the Genetic Information Nondiscrimination Act. To learn more about it, read this summary.
+Ask students if they would like their genomes to be sequenced. What would they gain by such knowledge? Have them consider who would versus who should have access to that information. Have students balance the benefits of being aware of a predisposition to a certain condition to the risk of having employment or health insurance denied. For some diseases, it is possible with the information on hand to modify one’s lifestyle and increase screening for early detection of the condition. What happens if there are no cures, as is the case for Huntington’s disease? This is the context of the Genetic Information Nondiscrimination Act. To learn more about it, read this summary.
diff --git a/modules/m62837/index.cnxml b/modules/m62837/index.cnxml
index 16bcfa364..23c55d4be 100644
--- a/modules/m62837/index.cnxml
+++ b/modules/m62837/index.cnxml
@@ -148,7 +148,7 @@
The genetic code is universal. With a few exceptions, virtually all species use the same genetic code for protein synthesis. Conservation of codons means that a purified mRNA encoding the globin protein in horses could be transferred to a tulip cell, and the tulip would synthesize horse globin. That there is only one genetic code is powerful evidence that all of life on Earth shares a common origin, especially considering that there are about 1084 possible combinations of 20 amino acids and 64 triplet codons.
-Transcribe a gene and translate it to protein using complementary pairing and the genetic code at this site.
+Transcribe a gene and translate it to protein using complementary pairing and the genetic code at this site.
diff --git a/modules/m62838/index.cnxml b/modules/m62838/index.cnxml
index cb91b269e..597927683 100644
--- a/modules/m62838/index.cnxml
+++ b/modules/m62838/index.cnxml
@@ -92,7 +92,7 @@ closed circle that, unlike eukaryotic chromosomes, is not organized around histo
The σ subunit of prokaryotic RNA polymerase recognizes consensus sequences found in the promoter region upstream of the transcription start sight. The σ subunit dissociates from the polymerase after transcription has been initiated.
-View this MolecularMovies animation to see the transcription process as it happens in the cell.
+View this MolecularMovies animation to see the transcription process as it happens in the cell.
@@ -123,7 +123,7 @@ closed circle that, unlike eukaryotic chromosomes, is not organized around histo
Multiple polymerases can transcribe a single bacterial gene while numerous ribosomes concurrently translate the mRNA transcripts into polypeptides. In this way, a specific protein can rapidly reach a high concentration in the bacterial cell.
-Visit this BioStudio animation to see the process of prokaryotic transcription.
+Visit this BioStudio animation to see the process of prokaryotic transcription.
diff --git a/modules/m62842/index.cnxml b/modules/m62842/index.cnxml
index 90c72e53a..fadc634e0 100644
--- a/modules/m62842/index.cnxml
+++ b/modules/m62842/index.cnxml
@@ -116,7 +116,7 @@
Note that more than 70 individual introns can be present, and each has to undergo the process of splicing—in addition to 5' capping and the addition of a poly-A tail—just to generate a single, translatable mRNA molecule.
-See how introns are removed during RNA splicing at this website.
+See how introns are removed during RNA splicing at this website.
diff --git a/modules/m62843/index.cnxml b/modules/m62843/index.cnxml
index 330edf72b..105fb6f2a 100644
--- a/modules/m62843/index.cnxml
+++ b/modules/m62843/index.cnxml
@@ -101,7 +101,7 @@
The Protein Synthesis MachineryIn addition to the mRNA template, many molecules and macromolecules contribute to the process of translation. The composition of each component may vary across species; for instance, ribosomes may consist of different numbers of rRNAs and polypeptides depending on the organism. However, the general structures and functions of the protein synthesis machinery are comparable from bacteria to human cells. Translation requires the input of an mRNA template, ribosomes, tRNAs, and various enzymatic factors.
-Click through the steps of this PBS interactive to see protein synthesis in action.
+Click through the steps of this PBS interactive to see protein synthesis in action.
diff --git a/modules/m62844/index.cnxml b/modules/m62844/index.cnxml
index f4347e984..e2c086a26 100644
--- a/modules/m62844/index.cnxml
+++ b/modules/m62844/index.cnxml
@@ -16,7 +16,7 @@
The genetic content of each somatic cell in an organism is the same, but not all genes are expressed in every cell. The control of which genes are expressed dictates whether a cell is (a) an eye cell or (b) a liver cell. It is the differential gene expression patterns that arise in different cells that give rise to (c) a complete organism.
Most people know that regular exercise is important to maintain good health. It promotes cardiovascular health and helps to prevent obesity. Scientists have now discovered that long-term endurance training also changes how genes are expressed in muscle tissue. In a recent study, 23 healthy people each exercised one leg for 45 minutes four days a week while resting the other leg. After three months, muscles from participants’ legs were biopsied, and scientists analyzed the activity level of over 20,000 genes in the tissue samples.
-They found that for each participant the exercised leg had reduced inflammation and improved metabolism compared with the non-exercised leg. These differences were accompanied by changes in genes associated with metabolism and inflammation. However, the actual nucleotide sequences of the genes weren’t changed. Instead, some genes were methylated, which simply means methyl groups were attached to certain nucleotides along the sequence. This, essentially, turned the genes “off” or otherwise changed how they were expressed. DNA methylation is an example of epigenetics, which is a process that alters genes without affecting the nucleotide sequence of the genes. The full research article can be found here.
+They found that for each participant the exercised leg had reduced inflammation and improved metabolism compared with the non-exercised leg. These differences were accompanied by changes in genes associated with metabolism and inflammation. However, the actual nucleotide sequences of the genes weren’t changed. Instead, some genes were methylated, which simply means methyl groups were attached to certain nucleotides along the sequence. This, essentially, turned the genes “off” or otherwise changed how they were expressed. DNA methylation is an example of epigenetics, which is a process that alters genes without affecting the nucleotide sequence of the genes. The full research article can be found here.
diff --git a/modules/m62845/index.cnxml b/modules/m62845/index.cnxml
index 8af83a579..3ea88a274 100644
--- a/modules/m62845/index.cnxml
+++ b/modules/m62845/index.cnxml
@@ -61,7 +61,7 @@
-Ask students what genes are present in the DNA in a muscle cell and skin cell. Ask them if the same genome is present in every cell in the body, how do the cells have different properties. For example, discuss red blood cells, which lose their nucleus during development. This video gives an overview of gene regulation in prokaryotes and eukaryotes.
+Ask students what genes are present in the DNA in a muscle cell and skin cell. Ask them if the same genome is present in every cell in the body, how do the cells have different properties. For example, discuss red blood cells, which lose their nucleus during development. This video gives an overview of gene regulation in prokaryotes and eukaryotes.
diff --git a/modules/m62846/index.cnxml b/modules/m62846/index.cnxml
index ebd3e7743..afb3619b7 100644
--- a/modules/m62846/index.cnxml
+++ b/modules/m62846/index.cnxml
@@ -78,8 +78,8 @@
-When discussing the operons with students, challenge them to think about what would happen if there were a gene mutation that disrupted the function of one of the proteins that controls transcription of the operon. For example, if the repressor protein in the lac operon has a mutation that prevents it from binding to lactose, then the repressor will remain bound to the operator and will prevent transcription of the operon even in the presence of lactose. This video describes two other examples of mutations in the lac operon.
-Introduce the regulation of transcription in the lac operon using visuals such as this video.
+When discussing the operons with students, challenge them to think about what would happen if there were a gene mutation that disrupted the function of one of the proteins that controls transcription of the operon. For example, if the repressor protein in the lac operon has a mutation that prevents it from binding to lactose, then the repressor will remain bound to the operator and will prevent transcription of the operon even in the presence of lactose. This video describes two other examples of mutations in the lac operon.
+Introduce the regulation of transcription in the lac operon using visuals such as this video.The DNA of prokaryotes is organized into a circular chromosome supercoiled in the nucleoid region of the cell cytoplasm. Proteins that are needed for a specific function, or that are involved in the same biochemical pathway, are encoded together in blocks called operons. For example, all of the genes needed to use lactose as an energy source are coded next to each other in the lactose (or lac) operon.
@@ -96,7 +96,7 @@
When tryptophan is not present in the cell, the repressor by itself does not bind to the operator; therefore, the operon is active and tryptophan is synthesized. Because the repressor protein actively binds to the operator to keep the genes turned off, the trp operon is negatively regulated and the proteins that bind to the operator to silence trp expression are negative regulators.
-Watch this video to learn more about the trp operon.
+Watch this video to learn more about the trp operon.
@@ -152,7 +152,7 @@
-Watch an animated tutorial about the workings of lac operon here.
+Watch an animated tutorial about the workings of lac operon here.
diff --git a/modules/m62847/index.cnxml b/modules/m62847/index.cnxml
index 29855d6c9..34c3057e4 100644
--- a/modules/m62847/index.cnxml
+++ b/modules/m62847/index.cnxml
@@ -61,7 +61,7 @@
As stated earlier, one reason why eukaryotic gene expression is more complex than prokaryotic gene expression is because the processes of transcription and translation are physically separated. Unlike prokaryotic cells, eukaryotic cells can regulate gene expression at many different levels. Eukaryotic gene expression begins with control of access to the DNA. This form of regulation, called epigenetic regulation, occurs even before transcription is initiated.
-Introduce epigenetics and have students work on an epigenetics activity found on the University of Utah’s website.
+Introduce epigenetics and have students work on an epigenetics activity found on the University of Utah’s website.The human genome encodes over 20,000 genes; each of the 23 pairs of human chromosomes encodes thousands of genes. The DNA in the nucleus is precisely wound, folded, and compacted into chromosomes so that it will fit into the nucleus. It is also organized so that specific segments can be accessed as needed by a specific cell type.The first level of organization, or packing, is the winding of DNA strands around histone proteins. Histones package and order DNA into structural units called nucleosome complexes, which can control the access of proteins to the DNA regions (a). Under the electron microscope, this winding of DNA around histone proteins to form nucleosomes looks like small beads on a string (b). These beads (histone proteins) can move along the string (DNA) and change the structure of the molecule.
@@ -112,7 +112,7 @@
-View this video that describes how epigenetic regulation controls gene expression.
+View this video that describes how epigenetic regulation controls gene expression.
diff --git a/modules/m62848/index.cnxml b/modules/m62848/index.cnxml
index c53ae83e6..4fbd498bc 100644
--- a/modules/m62848/index.cnxml
+++ b/modules/m62848/index.cnxml
@@ -124,7 +124,7 @@
In Drosophila melanogaster, the sex is determined by a series of splicing events in sex determination genes on a cell-by-cell basis without any involvement of sex hormones (which circulate throughout the entire body). The primary sex-determination gene is Sex lethal (Sxl), which is transcribed only when the X/A ratio (the X chromosome-to-autosome ratio) equals or exceeds 1. As females have two X chromosomes and males have one, Sxl is transcribed only in females (see the figure, left part). Sxl is a splicing repressor and binds to its target, the primary RNA of the transformer (tra) gene, which undergoes differential splicing depending on the presence (female) or absence (male) of Sxl, yielding a protein-coding tra mRNA only in females. The Tra protein binds to the primary RNAs of doublesex (dsx) and fruitless (fru). In females, Tra promotes splicing to occur near its binding site, whereas in males it uses an alternative, default splice site. The dsx primary RNA thus produces female-specific mRNA and male-specific mRNA, both of which encode functional Dsx proteins, DsxF and DsxM, respectively. The presence (female) and absence (male) of Tra similarly results in female-type fru mRNA and male-type fru mRNA, but here, only the male-type fru mRNA encodes a functional protein.
- View the process of transcription—the making of RNA from a DNA template—at this site.
+ View the process of transcription—the making of RNA from a DNA template—at this site.
diff --git a/modules/m62849/index.cnxml b/modules/m62849/index.cnxml
index e2f4cad5d..83c82d5f3 100644
--- a/modules/m62849/index.cnxml
+++ b/modules/m62849/index.cnxml
@@ -69,9 +69,9 @@
-Introduce mRNA modifications using videos such as this one about 5'caps and 3'poly-A tails.
+Introduce mRNA modifications using videos such as this one about 5'caps and 3'poly-A tails.
-Students may not realize that splicing occurs with variation, not all introns are excised in exactly the same way all of the time. Differential splicing produces different protein products. This one introduces RNA splicing.
+Students may not realize that splicing occurs with variation, not all introns are excised in exactly the same way all of the time. Differential splicing produces different protein products. This one introduces RNA splicing.
@@ -100,7 +100,7 @@
-Visualize how mRNA splicing happens by watching the process in action in this video.
+Visualize how mRNA splicing happens by watching the process in action in this video.
diff --git a/modules/m62850/index.cnxml b/modules/m62850/index.cnxml
index f60c2d930..20afd3a9a 100644
--- a/modules/m62850/index.cnxml
+++ b/modules/m62850/index.cnxml
@@ -56,7 +56,7 @@
-Introduce the topic of post-translation gene regulation using visuals such as this video.
+Introduce the topic of post-translation gene regulation using visuals such as this video.After the RNA has been transported to the cytoplasm, it is translated into protein. Control of this process is largely dependent on the RNA molecule. As previously discussed, the stability of the RNA will have a large impact on its translation into a protein. As the stability changes, the amount of time that it is available for translation also changes.
diff --git a/modules/m62851/index.cnxml b/modules/m62851/index.cnxml
index a28bf4125..c889896af 100644
--- a/modules/m62851/index.cnxml
+++ b/modules/m62851/index.cnxml
@@ -84,7 +84,7 @@
-Introduce the topic of cancer and gene regulation using visuals such as this video.
+Introduce the topic of cancer and gene regulation using visuals such as this video.
@@ -98,7 +98,7 @@
Tumor Suppressor Genes, Oncogenes, and CancerIn normal cells, some genes function to prevent excess, inappropriate cell growth. These are tumor suppressor genes, which are active in normal cells to prevent uncontrolled cell growth. There are many tumor suppressor genes in cells. The most studied tumor suppressor gene is p53, which is mutated in over 50 percent of all cancer types. The p53 protein itself functions as a transcription factor. It can bind to sites in the promoters of genes to initiate transcription. Therefore, the mutation of p53 in cancer will dramatically alter the transcriptional activity of its target genes.
- Watch this animation to learn more about the use of p53 in fighting cancer.
+ Watch this animation to learn more about the use of p53 in fighting cancer.
diff --git a/modules/m62852/index.cnxml b/modules/m62852/index.cnxml
index acb7ad3a9..a6965971b 100644
--- a/modules/m62852/index.cnxml
+++ b/modules/m62852/index.cnxml
@@ -14,7 +14,7 @@
In genomics, the DNA of different organisms is compared, enabling scientists to create maps with which to navigate the DNA of different organisms. (credit "map": modification of photo by NASA)
Some of the greatest accomplishments of biotechnology are in the fields of medicine and medical research. For example, intestinal failure due to missing or abnormal intestinal tissue is a frequent problem in premature babies. Intestinal problems are also common for people who have had parts of their small intestines removed for reasons , such as Crohn’s Disease, cancer, and blockages. Complications from intestinal failure may include liver disease, bacterial overgrowth, dehydration, and malnutrition.
-Scientists have recently developed a way to engineer human intestines from human cells using mice. Using a mixture of healthy mouse and human intestinal cells and placing it on scaffolding in the abdominal cavity of immunocompromised mice, functional human intestinal cells grow within four weeks. This could be the breakthrough needed to help patients suffering from intestinal failure. More details about this exciting research can be found here.
+Scientists have recently developed a way to engineer human intestines from human cells using mice. Using a mixture of healthy mouse and human intestinal cells and placing it on scaffolding in the abdominal cavity of immunocompromised mice, functional human intestinal cells grow within four weeks. This could be the breakthrough needed to help patients suffering from intestinal failure. More details about this exciting research can be found here.This chapter gives the instructor the opportunity to explore the developments in the areas of biotechnology and genomics for both the good and detriment of individuals and society. The newest developments will have exceeded the scope of this text and will need to be supplemented during the course.
diff --git a/modules/m62853/index.cnxml b/modules/m62853/index.cnxml
index 7208e4f35..d58deaa2e 100644
--- a/modules/m62853/index.cnxml
+++ b/modules/m62853/index.cnxml
@@ -124,7 +124,7 @@
Polymerase chain reaction, or PCR, is used to amplify a specific sequence of DNA. Primers—short pieces of DNA complementary to each end of the target sequence—are combined with genomic DNA, Taq polymerase, and deoxynucleotides. Taq polymerase is a DNA polymerase isolated from the thermostable bacterium Thermus aquaticus that is able to withstand the high temperatures used in PCR. Thermus aquaticus grows in the Lower Geyser Basin of Yellowstone National Park. Reverse transcriptase PCR (RT-PCR) is similar to PCR, but cDNA is made from an RNA template before PCR begins.
DNA fragments can also be amplified from an RNA template in a process called reverse transcriptase PCR (RT-PCR). The first step is to recreate the original DNA template strand (called cDNA) by applying DNA nucleotides to the mRNA. This process is called reverse transcription. This requires the presence of an enzyme called reverse transcriptase. After the cDNA is made, regular PCR can be used to amplify it.
-Deepen your understanding of the polymerase chain reaction by clicking through this interactive exercise.
+Deepen your understanding of the polymerase chain reaction by clicking through this interactive exercise.
@@ -167,7 +167,7 @@
-View an animation of recombination in cloning from the DNA Learning Center.
+View an animation of recombination in cloning from the DNA Learning Center.
@@ -200,7 +200,7 @@
Suggested group size for the activity is 3–6 students. Guide student groups to think about climate change as a natural selection pressure that will affect the success of the clones. By using crop plants with little genetic variation, there is little potential that these plants to withstand an environmental change such as rapid, human-induced global warming.The activity is an application of Learning Objective 3.5 and Science Practice 6.4 because students are discussing the justification for cloning crop plants and then predicting how climate change will act as a selection pressure on the clones.The Think About It question is an application of Learning Objective 3.5 and Science Practice 6.4 because the technique for introducing new genes into an organism is an example of how heritable information can be manipulated.
-An expanded lab investigation for biotechnology, involving performing a genetic transformation on E. coli, is available from the College Board’s® AP Biology Investigative Labs: An Inquiry-Based Approach in Investigation 8.
+An expanded lab investigation for biotechnology, involving performing a genetic transformation on E. coli, is available from the College Board’s® AP Biology Investigative Labs: An Inquiry-Based Approach in Investigation 8.Answer:
Alter a plant RNA virus to contain the gene for herbicide resistance. Use the virus as a vector to place the gene into appropriate plants.
diff --git a/modules/m62855/index.cnxml b/modules/m62855/index.cnxml
index 636c3f86d..6d6914636 100644
--- a/modules/m62855/index.cnxml
+++ b/modules/m62855/index.cnxml
@@ -97,7 +97,7 @@
-Mapping is the first step in examining the genome of an organism. Some of the techniques have been used for years while others were developed with the advances in technology. In addition to discussing the details of this subject, this may be a good time to discuss the genetic similarities between “races” of people and between humans and other organisms. A very good movie about this has been put out by PBS, here. Obtain examples of genetic and physical maps and cytogenetic maps for humans and other species to use in general teaching and in the discussions suggested above.
+Mapping is the first step in examining the genome of an organism. Some of the techniques have been used for years while others were developed with the advances in technology. In addition to discussing the details of this subject, this may be a good time to discuss the genetic similarities between “races” of people and between humans and other organisms. A very good movie about this has been put out by PBS, here. Obtain examples of genetic and physical maps and cytogenetic maps for humans and other species to use in general teaching and in the discussions suggested above.Genomics is the study of entire genomes, including the complete set of genes, their nucleotide sequence and organization, and their interactions within a species and with other species. Genome mapping is the process of finding the locations of genes on each chromosome. The maps created by genome mapping are comparable to the maps that we use to navigate streets. A genetic map is an illustration that lists genes and their location on a chromosome. Genetic maps provide the big picture (similar to a map of interstate highways) and use genetic markers (similar to landmarks). A genetic marker is a gene or sequence on a chromosome that co-segregates (shows genetic linkage) with a specific trait. Early geneticists called this linkage analysis. Physical maps present the intimate details of smaller regions of the chromosomes (similar to a detailed road map). A physical map is a representation of the physical distance, in nucleotides, between genes or genetic markers. Both genetic linkage maps and physical maps are required to build a complete picture of the genome. Having a complete map of the genome makes it easier for researchers to study individual genes. Human genome maps help researchers in their efforts to identify human disease-causing genes related to illnesses like cancer, heart disease, and cystic fibrosis. Genome mapping can be used in a variety of other applications, such as using live microbes to clean up pollutants or even prevent pollution. Research involving plant genome mapping may lead to producing higher crop yields or developing plants that better adapt to climate change.
@@ -129,10 +129,10 @@
How to Use a Genome Map ViewerProblem statement: Do the human, macaque, and mouse genomes contain common DNA sequences?Develop a hypothesis.
-To test the hypothesis, click this link.In Search box on the left panel, type any gene name or phenotypic characteristic, such as iris pigmentation (eye color). Select the species you want to study, and then press Enter. The genome map viewer will indicate which chromosome encodes the gene in your search. Click each hit in the genome viewer for more detailed information. This type of search is the most basic use of the genome viewer; it can also be used to compare sequences between species, as well as many other complicated tasks.
+To test the hypothesis, click this link.In Search box on the left panel, type any gene name or phenotypic characteristic, such as iris pigmentation (eye color). Select the species you want to study, and then press Enter. The genome map viewer will indicate which chromosome encodes the gene in your search. Click each hit in the genome viewer for more detailed information. This type of search is the most basic use of the genome viewer; it can also be used to compare sequences between species, as well as many other complicated tasks.Is the hypothesis correct? Why or why not?
-Online Mendelian Inheritance in Man (OMIM) is a searchable online catalog of human genes and genetic disorders. This website shows genome mapping information, and also details the history and research of each trait and disorder. Click this link to search for traits (such as handedness) and genetic disorders (such as diabetes).
+Online Mendelian Inheritance in Man (OMIM) is a searchable online catalog of human genes and genetic disorders. This website shows genome mapping information, and also details the history and research of each trait and disorder. Click this link to search for traits (such as handedness) and genetic disorders (such as diabetes).
diff --git a/modules/m62857/index.cnxml b/modules/m62857/index.cnxml
index ed34e2a85..438f18cc0 100644
--- a/modules/m62857/index.cnxml
+++ b/modules/m62857/index.cnxml
@@ -49,7 +49,7 @@
Since 2005, automated sequencing techniques used by laboratories are under the umbrella of next-generation sequencing, which is a group of automated techniques used for rapid DNA sequencing. These automated low-cost sequencers can generate sequences of hundreds of thousands or millions of short fragments (25 to 500 base pairs) in the span of one day. These sequencers use sophisticated software to get through the cumbersome process of putting all the fragments in order.Comparing Sequences
-A sequence alignment is an arrangement of proteins, DNA, or RNA; it is used to identify regions of similarity between cell types or species, which may indicate conservation of function or structures. Sequence alignments may be used to construct phylogenetic trees. The following website uses a software program called BLAST (basic local alignment search tool).Under “Basic Blast,” click “Nucleotide Blast.” Input the following sequence into the large "query sequence" box: ATTGCTTCGATTGCA. Below the box, locate the "Species" field and type "human" or "Homo sapiens". Then click “BLAST” to
+A sequence alignment is an arrangement of proteins, DNA, or RNA; it is used to identify regions of similarity between cell types or species, which may indicate conservation of function or structures. Sequence alignments may be used to construct phylogenetic trees. The following website uses a software program called BLAST (basic local alignment search tool).Under “Basic Blast,” click “Nucleotide Blast.” Input the following sequence into the large "query sequence" box: ATTGCTTCGATTGCA. Below the box, locate the "Species" field and type "human" or "Homo sapiens". Then click “BLAST” to
compare the inputted sequence against known sequences of the human genome. The result is that this sequence occurs in over a hundred places in the human genome. Scroll down below the graphic with the horizontal bars and you will see short description of each of the matching hits. Pick one of the hits near the top of the list and click on "Graphics". This will bring you to a page that shows where the sequence is found within the entire human genome. You can move the slider that looks like a green flag back and forth to view the sequences immediately around the selected gene. You can then return to your selected sequence by clicking the "ATG" button.
@@ -67,7 +67,7 @@ compare the inputted sequence against known sequences of the human genome. The r
Use of Whole-Genome Sequences of Model OrganismsThe first genome to be completely sequenced was of a bacterial virus, the bacteriophage fx174 (5368 base pairs); this was accomplished by Fred Sanger using shotgun sequencing. Several other organelle and viral genomes were later sequenced. The first organism whose genome was sequenced was the bacterium Haemophilus influenzae; this was accomplished by Craig Venter in the 1980s. Approximately 74 different laboratories collaborated on the sequencing of the genome of the yeast Saccharomyces cerevisiae, which began in 1989 and was completed in 1996, because it was 60 times bigger than any other genome that had been sequenced. By 1997, the genome sequences of two important model organisms were available: the bacterium Escherichia coli K12 and the yeast Saccharomyces cerevisiae. Genomes of other model organisms, such as the mouse Mus musculus, the fruit fly Drosophila melanogaster, the nematode Caenorhabditis. elegans, and humans Homo sapiens are now known. A lot of basic research is performed in model organisms because the information can be applied to genetically similar organisms. A model organism is a species that is studied as a model to understand the biological processes in other species represented by the model organism. Having entire genomes sequenced helps with the research efforts in these model organisms. The process of attaching biological information to gene sequences is called genome annotation. Annotation of gene sequences helps with basic experiments in molecular biology, such as designing PCR primers and RNA targets.
-Click through each step of genome sequencing at this site.
+Click through each step of genome sequencing at this site.
diff --git a/modules/m62862/index.cnxml b/modules/m62862/index.cnxml
index 58931f92f..aae629cb9 100644
--- a/modules/m62862/index.cnxml
+++ b/modules/m62862/index.cnxml
@@ -13,7 +13,7 @@
-
All organisms are products of evolution adapted to their environment. (a) Saguaro (Carnegiea gigantea) can soak up 750 liters of water in a single rain storm, enabling these cacti to survive the dry conditions of the Sonora desert in Mexico and the Southwestern United States. (b) The Andean semiaquatic lizard (Potamites montanicola) discovered in Peru in 2010 lives between 1,570 to 2,100 meters in elevation, and, unlike most lizards, is nocturnal and swims. Scientists still do no know how these ectotherms, which rely on external sources of body heat, are able to move in the cold (10 to 15°C) temperatures of the Andean night. (credit a: modification of work by Gentry George, U.S. Fish and Wildlife Service; credit b: modification of work by Germán Chávez and Diego Vásquez, ZooKeys)
The field of biology is a diverse one that includes the study of organisms from the small and simple to the large and complex. From biological molecules to biomes, the one theme that remains consistent is evolution. All species of living organisms are descended from a common ancestor. Although it may seem that living things today stay much the same, this is not the case. Evolution is actually an ongoing process. Additionally, new species are discovered regularly. For example, scientists have used a method called fluorescent in situ hybridization, which uses fluorescent probes to locate specific genes on chromosomes, to discover a green sea slug that can perform photosynthesis just like a plant.Biol. Bull. 227: 300–312. (December 2014) The slug obtains genes related to photosynthesis from the algae it eats through a process called horizontal gene transfer. In this process, genes can be transferred directly from one cell to another. The algal genes code for products that repair and maintain chloroplasts eaten by the slug. You can read more about it at this website.
+
All organisms are products of evolution adapted to their environment. (a) Saguaro (Carnegiea gigantea) can soak up 750 liters of water in a single rain storm, enabling these cacti to survive the dry conditions of the Sonora desert in Mexico and the Southwestern United States. (b) The Andean semiaquatic lizard (Potamites montanicola) discovered in Peru in 2010 lives between 1,570 to 2,100 meters in elevation, and, unlike most lizards, is nocturnal and swims. Scientists still do no know how these ectotherms, which rely on external sources of body heat, are able to move in the cold (10 to 15°C) temperatures of the Andean night. (credit a: modification of work by Gentry George, U.S. Fish and Wildlife Service; credit b: modification of work by Germán Chávez and Diego Vásquez, ZooKeys)
The field of biology is a diverse one that includes the study of organisms from the small and simple to the large and complex. From biological molecules to biomes, the one theme that remains consistent is evolution. All species of living organisms are descended from a common ancestor. Although it may seem that living things today stay much the same, this is not the case. Evolution is actually an ongoing process. Additionally, new species are discovered regularly. For example, scientists have used a method called fluorescent in situ hybridization, which uses fluorescent probes to locate specific genes on chromosomes, to discover a green sea slug that can perform photosynthesis just like a plant.Biol. Bull. 227: 300–312. (December 2014) The slug obtains genes related to photosynthesis from the algae it eats through a process called horizontal gene transfer. In this process, genes can be transferred directly from one cell to another. The algal genes code for products that repair and maintain chloroplasts eaten by the slug. You can read more about it at this website.
diff --git a/modules/m62863/index.cnxml b/modules/m62863/index.cnxml
index f71a8a1fe..4b5649db2 100644
--- a/modules/m62863/index.cnxml
+++ b/modules/m62863/index.cnxml
@@ -261,7 +261,7 @@
The similar construction of these appendages indicates that these organisms share a common ancestor.
Some structures exist in organisms that have no apparent function at all, and appear to be residual parts from a past common ancestor. These unused structures without function are called vestigial structures. Examples of vestigial structures include wings on flightless birds, leaves on some cacti, and hind leg bones in whales.
-Visit this interactive site to guess which bones structures are homologous and which are analogous, and see examples of evolutionary adaptations to illustrate these concepts.
+Visit this interactive site to guess which bones structures are homologous and which are analogous, and see examples of evolutionary adaptations to illustrate these concepts.
@@ -305,7 +305,7 @@
Misconceptions of EvolutionAlthough the theory of evolution generated some controversy when it was first proposed, it was almost universally accepted by biologists, particularly younger biologists, within 20 years after publication of On theOrigin of Species. Nevertheless, the theory of evolution is a difficult concept and misconceptions about how it works abound.
-This site addresses some of the main misconceptions associated with the theory of evolution.
+This site addresses some of the main misconceptions associated with the theory of evolution.
diff --git a/modules/m62864/index.cnxml b/modules/m62864/index.cnxml
index 4f433d650..5046aa422 100644
--- a/modules/m62864/index.cnxml
+++ b/modules/m62864/index.cnxml
@@ -256,7 +256,7 @@
The honeycreeper birds illustrate adaptive radiation. From one original species of bird, multiple others evolved, each with its own distinctive characteristics.
Notice the differences in the species’ beaks in . Evolution in response to natural selection based on specific food sources in each new habitat led to evolution of a different beak suited to the specific food source. The seed-eating bird has a thicker, stronger beak which is suited to break hard nuts. The nectar-eating birds have long beaks to dip into flowers to reach the nectar. The insect-eating birds have beaks like swords, appropriate for stabbing and impaling insects. Darwin’s finches are another example of adaptive radiation in an archipelago.
-Click through this interactive site to see how island birds evolved in evolutionary increments from 5 million years ago to today.
+Click through this interactive site to see how island birds evolved in evolutionary increments from 5 million years ago to today.
diff --git a/modules/m62865/index.cnxml b/modules/m62865/index.cnxml
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The primary influencing factor on changes in speciation rate is environmental conditions. Under some conditions, selection occurs quickly or radically. Consider a species of snails that had been living with the same basic form for many thousands of years. Layers of their fossils would appear similar for a long time. When a change in the environment takes place—such as a drop in the water level—a small number of organisms are separated from the rest in a brief period of time, essentially forming one large and one tiny population. The tiny population faces new environmental conditions. Because its gene pool quickly became so small, any variation that surfaces and that aids in surviving the new conditions becomes the predominant form.
-Visit this website to continue the speciation story of the snails.
+Visit this website to continue the speciation story of the snails.
-Take an up-close tour through the sponge and its cells.
+Take an up-close tour through the sponge and its cells.As we’ve seen, most sponges are supported by small bone-like spicules (usually tiny pointed structures made of calcium carbonate or silica) in the mesohyl. Spicules provide support for the body of the sponge, and may also deter predation. The presence and composition of spicules form the basis for differentiating three of the four classes of sponges (). Sponges in class Calcarea produce calcium carbonate spicules and no spongin; those in class Hexactinellida produce six-rayed siliceous (glassy) spicules and no spongin; and those in class Demospongia contain spongin and may or may not have spicules; if present, those spicules are siliceous. Sponges in this last class have been used as bath sponges. Spicules are most conspicuously present in the glass sponges, class Hexactinellida. Some of the spicules may attain gigantic proportions. For example, relative to typical glass sponge spicules, whose size generally ranges from 3 to 10 mm, some of the basal spicules of the hexactinellid Monorhaphis chuni are enormous and grow up to 3 meters long! The glass sponges are also unusual in that most of their body cells are fused together to form a multinucleate syncytium. Because their cells are interconnected in this way, the hexactinellid sponges have no mesohyl. A fourth class of sponges, the Sclerospongiae, was described from species discovered in underwater tunnels. These are also called coralline sponges after their multilayered calcium carbonate skeletons. Dating based on the rate of deposition of the skeletal layers suggests that some of these sponges are hundreds of years old.
Several classes of sponges. (a) Clathrina clathrus belongs to class Calcarea, (b) Staurocalyptus spp. (common name: yellow Picasso sponge) belongs to class Hexactinellida, and (c) Acarnus erithacus belongs to class Demospongia. (credit a: modification of work by Parent Géry; credit b: modification of work by Monterey Bay Aquarium Research Institute, NOAA; credit c: modification of work by Sanctuary Integrated Monitoring Network, Monterey Bay National Marine Sanctuary, NOAA)
-Use the Interactive Sponge Guide to identify species of sponges based on their external form, mineral skeleton, fiber, and skeletal architecture.
+Use the Interactive Sponge Guide to identify species of sponges based on their external form, mineral skeleton, fiber, and skeletal architecture.Physiological Processes in SpongesSponges, despite being simple organisms, regulate their different physiological processes through a variety of mechanisms. These processes regulate their metabolism, reproduction, and locomotion.
@@ -74,7 +74,7 @@
LocomotionSponges are generally sessile as adults and spend their lives attached to a fixed substratum. They do not show movement over large distances like other free-swimming marine invertebrates. However, sponge cells are capable of creeping along substrata via organizational plasticity, i.e., rearranging their cells. Under experimental conditions, researchers have shown that sponge cells spread on a physical support demonstrate a leading edge for directed movement. It has been speculated that this localized creeping movement may help sponges adjust to microenvironments near the point of attachment. It must be noted, however, that this pattern of movement has been documented in laboratories, it remains to be observed in natural sponge habitats.
-Watch this BBC video showing the array of sponges seen along the Cayman Wall during a submersible dive.
+Watch this BBC video showing the array of sponges seen along the Cayman Wall during a submersible dive.Section SummaryAnimals included in phylum Porifera are parazoans because they do not show the formation of true embryonically derived tissues, although they have a number of specific cell types and “functional” tissues such as pinacoderm. These organisms show very simple organization, with a rudimentary endoskeleton of spicules and spongin fibers. Glass sponge cells are connected together in a multinucleated syncytium. Although sponges are very simple in organization, they perform most of the physiological functions typical of more complex animals.
diff --git a/modules/m66395/index.cnxml b/modules/m66395/index.cnxml
index aec907db5..3093f4d2d 100644
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Obelia. The colonial sessile form of Obelia geniculata has two types of polyps: gastrozooids, which are adapted for capturing prey, and gonozooids, which asexually bud to produce medusae.
-Click here to follow an Obelia life cycle animation.
+Click here to follow an Obelia life cycle animation.All cnidarians are diploblastic and thus have two “epithelial” layers in the body that are derived from the endoderm and ectoderm of the embryo. The outer layer (from ectoderm) is called the epidermis and lines the outside of the animal, whereas the inner layer (from endoderm) is called the gastrodermis and lines the digestive cavity. In the planula larva, a layer of ectoderm surrounds a solid mass of endoderm, but as the polyp develops, the digestive or gastrovascular cavity opens within the endoderm. A non-living, jelly-like mesoglea lies between these two epithelial layers. In terms of cellular complexity, cnidarians show the presence of differentiated cell types in each tissue layer, such as nerve cells, contractile epithelial cells, enzyme-secreting cells, and nutrient-absorbing cells, as well as the presence of intercellular connections. However, with a few notable exceptions such as statocysts and rhopalia (see below), the development of organs or organ systems is not advanced in this phylum.The nervous system is rudimentary, with nerve cells organized in a network scattered across the body. This nerve net may show the presence of groups of cells that form nerve plexi (singular: plexus) or nerve cords. Organization of the nervous system in the motile medusa is more complex than that of the sessile polyp, with a nerve ring around the edge of the medusa bell that controls the action of the tentacles. Cnidarian nerve cells show mixed characteristics of motor and sensory neurons. The predominant signaling molecules in these primitive nervous systems are peptides, which perform both excitatory and inhibitory functions. Despite the simplicity of the nervous system, it is remarkable that it coordinates the complicated movement of the tentacles, the drawing of captured prey to the mouth, the digestion of food, and the expulsion of waste.
diff --git a/modules/m66396/index.cnxml b/modules/m66396/index.cnxml
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Rotifers are commonly found in freshwater and some saltwater environments throughout the world. As filter feeders, they will eat dead material, algae, and other microscopic living organisms, and are therefore very important components of aquatic food webs. A rotifer's food is directed toward the mouth by the current created from the movement of the coronal cilia. The food particles enter the mouth and travel first to the mastax—a muscular pharynx with toothy jaw-like structures. Examples of the jaws of various rotifers are seen in a. Masticated food passes near digestive and salivary glands, into the stomach, and then to the intestines. Digestive and excretory wastes are collected in a cloacal bladder before being released out the anus.
-Watch this video to see rotifers feeding.
+Watch this video to see rotifers feeding.About 2,200 species of rotifers have been identified. shows the anatomy of a rotifer belonging to class Bdelloidea. Some rotifers are dioecious organisms and exhibit sexual dimorphism (males and females have different forms). In many dioecious species, males are short-lived and smaller with no digestive system and a single testis. Many rotifer species exhibit haplodiploidy, a method of sex determination in which a fertilized egg develops into a female and an unfertilized egg develops into a male. However, reproduction in the bdelloid rotifers is exclusively parthenogenetic and appears to have been so for millions of years: Thus, all bdelloid rotifers and their progeny are female! The bdelloids may compensate for this genetic insularity by borrowing genes from the DNA of other species. Up to 10% of a bdelloid genome comprises genes imported from related species. Some rotifer eggs are capable of extended dormancy for protection during harsh environmental conditions.
diff --git a/modules/m66397/index.cnxml b/modules/m66397/index.cnxml
index 39d185187..e0a989c59 100644
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@@ -59,9 +59,9 @@
-
Bivalves. These mussels (a), found in the intertidal zone in Cornwall, England, show the bivalve shell. The scallop Argopecten irradians (b) has a fluted shell and conspicuous eyespots. (credit (a): Mark A. Wilson. credit (b) Rachael Norris and Marina Freudzon. https://commons.wikimedia.org/w/index.php?curid=17251065)
One of the functions of the mantle is to secrete the shell. Some bivalves, like oysters and mussels, possess the unique ability to secrete and deposit a calcareous nacre or “mother of pearl” around foreign particles that may enter the mantle cavity. This property has been commercially exploited to produce pearls.
+
Bivalves. These mussels (a), found in the intertidal zone in Cornwall, England, show the bivalve shell. The scallop Argopecten irradians (b) has a fluted shell and conspicuous eyespots. (credit (a): Mark A. Wilson. credit (b) Rachael Norris and Marina Freudzon. https://commons.wikimedia.org/w/index.php?curid=17251065)
One of the functions of the mantle is to secrete the shell. Some bivalves, like oysters and mussels, possess the unique ability to secrete and deposit a calcareous nacre or “mother of pearl” around foreign particles that may enter the mantle cavity. This property has been commercially exploited to produce pearls.
-Watch the animations of bivalves feeding: View the process in clams and mussels at these sites.
+Watch the animations of bivalves feeding: View the process in clams and mussels at these sites.More than half of molluscan species are in the class Gastropoda (“stomach foot”), which includes well-known mollusks like snails, slugs, conchs, cowries, limpets, and whelks. Aquatic gastropods include both marine and freshwater species, and all terrestrial mollusks are gastropods. Gastropoda includes shell-bearing species as well as species without shells. Gastropod bodies are asymmetrical and usually present a coiled shell (a). Shells may be planospiral (like a garden hose wound up), commonly seen in garden snails, or conispiral, (like a spiral staircase), commonly seen in marine conches. Cowrie shells have a polished surface because the mantle extends up over the top of the shell as it is secreted.
diff --git a/modules/m66398/index.cnxml b/modules/m66398/index.cnxml
index c177f68ac..d956819e3 100644
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-
Scanning electronmicrograph of Milnesium tardigradum. (credit: Schokraie E, Warnken U, Hotz-Wagenblatt A, Grohme MA, Hengherr S, et al. (2012) -https://commons.wikimedia.org/w/index.php?curid=22716809)
+
Scanning electronmicrograph of Milnesium tardigradum. (credit: Schokraie E, Warnken U, Hotz-Wagenblatt A, Grohme MA, Hengherr S, et al. (2012) -https://commons.wikimedia.org/w/index.php?curid=22716809)
Morphology and PhysiologyTardigrades have cylindrical bodies, with four pairs of legs terminating in a number of claws. The cuticle is periodically shed, including the cuticular covering of the claws. The first three pairs of legs are used for walking, and the posterior pair for clinging to the substrate. A circular mouth leads to a muscular pharynx and salivary glands. Tardigrades feed on plants, algae, or small animals. Plant cells are pierced with a chitinous stylet and the cellular contents are then sucked into the gut by the muscular pharynx. Bands of single muscle cells are attached to the various points of the epidermis and extend into the legs to provide ambulatory movement. The major body cavity is a hemocoel, but there are no specialized circulatory structures for moving the blood, nor are there specialized respiratory structures. Malpighian tubules in the hemocoel remove metabolic wastes and transport them to the gut. A dorsal brain is connected to a ventral nerve cord with segmental ganglia associated with the appendages. Sensory structures are greatly reduced, but there is a pair of simple eyespots on the head, and sensory cilia or bristles concentrated toward the head end of the animal.
diff --git a/modules/m66399/index.cnxml b/modules/m66399/index.cnxml
index c2aa11ff5..9302b046a 100644
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Spider. The trapdoor spider, like all spiders, is a member of the subphylum Chelicerata. (credit: Marshal Hedin)
The nervous system in chelicerates consists of a brain and two ventral nerve cords. Chelicerates are dioecious, meaning that the sexes are separate. These animals use external fertilization as well as internal fertilization strategies for reproduction, depending upon the species and its habitat. Parental care for the young ranges from absolutely none to relatively prolonged care.
-Visit this site to click through a lesson on arthropods, including interactive habitat maps, and more.
+Visit this site to click through a lesson on arthropods, including interactive habitat maps, and more.
@@ -139,7 +139,7 @@
-
Crustaceans. The (a) crab and (b) shrimp krill are both aquatic crustaceans. The pill bug Armadillidium is a terrestrial crustacean. (credit a: modification of work by William Warby; credit b: modification of work by Jon Sullivan credit c: modification of work by Franco Folini. https://commons.wikimedia.org/w/index.php?curid=789616)
Crustaceans typically possess two pairs of antennae, mandibles as mouthparts, and biramous (“two branched”) appendages, which means that their legs are formed in two parts called endopods and exopods, which appear superficially distinct from the uniramous (“one branched”) legs of myriapods and hexapods (). Since biramous appendages are also seen in the trilobites, biramous appendages represent the ancestral condition in the arthropods. Currently, we describe various arthropods as having uniramous or biramous appendages, but these are descriptive only, and do not necessarily reflect evolutionary relationships other than that all jointed legs of arthropods share common ancestry.
+
Crustaceans. The (a) crab and (b) shrimp krill are both aquatic crustaceans. The pill bug Armadillidium is a terrestrial crustacean. (credit a: modification of work by William Warby; credit b: modification of work by Jon Sullivan credit c: modification of work by Franco Folini. https://commons.wikimedia.org/w/index.php?curid=789616)
Crustaceans typically possess two pairs of antennae, mandibles as mouthparts, and biramous (“two branched”) appendages, which means that their legs are formed in two parts called endopods and exopods, which appear superficially distinct from the uniramous (“one branched”) legs of myriapods and hexapods (). Since biramous appendages are also seen in the trilobites, biramous appendages represent the ancestral condition in the arthropods. Currently, we describe various arthropods as having uniramous or biramous appendages, but these are descriptive only, and do not necessarily reflect evolutionary relationships other than that all jointed legs of arthropods share common ancestry.
diff --git a/modules/m66400/index.cnxml b/modules/m66400/index.cnxml
index 6095cba36..cbc47ab3a 100644
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This phylum is divided into five extant classes: Asteroidea (sea stars), Ophiuroidea (brittle stars), Echinoidea (sea urchins and sand dollars), Crinoidea (sea lilies or feather stars), and Holothuroidea (sea cucumbers) ().The most well-known echinoderms are members of class Asteroidea, or sea stars. They come in a large variety of shapes, colors, and sizes, with more than 1,800 species known so far. The key characteristic of sea stars that distinguishes them from other echinoderm classes includes thick arms that extend from a central disk from which various body organs branch into the arms. At the end of each arm are simple eye spots and tentacles that serve as touch receptors. Sea stars use their rows of tube feet not only for gripping surfaces but also for grasping prey. Most sea stars are carnivores and their major prey are in the phylum Mollusca. By manipulating its tube feet, a sea star can open molluscan shells. Sea stars have two stomachs, one of which can protrude through their mouths and secrete digestive juices into or onto prey, even before ingestion. A sea star eating a clam can partially open the shell, and then evert its stomach into the shell, introducing digestive enzymes into the interior of the mollusk. This process can both weaken the strong adductor (closing) muscles of a bivalve and begin the process of digestion.
-Explore the sea star’s body plan up close, watch one move across the sea floor, and see it devour a mussel.
+Explore the sea star’s body plan up close, watch one move across the sea floor, and see it devour a mussel.Brittle stars belong to the class Ophiuroidea ("snake-tails"). Unlike sea stars, which have plump arms, brittle stars have long, thin, flexible arms that are sharply demarcated from the central disk. Brittle stars move by lashing out their arms or wrapping them around objects and pulling themselves forward. Their arms are also used for grasping prey. The water vascular system in ophiuroids is not used for locomotion.Sea urchins and sand dollars are examples of Echinoidea ("prickly"). These echinoderms do not have arms, but are hemispherical or flattened with five rows of tube feet that extend through five rows of pores in a continuous internal shell called a test. Their tube feet are used to keep the body surface clean. Skeletal plates around the mouth are organized into a complex multipart feeding structure called "Aristotle's lantern." Most echinoids graze on algae, but some are suspension feeders, and others may feed on small animals or organic detritus—the fragmentary remains of plants or animals.Sea lilies and feather stars are examples of Crinoidea. Sea lilies are sessile, with the body attached to a stalk, but the feather stars can actively move about using leglike cirri that emerge from the aboral surface. Both types of crinoid are suspension feeders, collecting small food organisms along the ambulacral grooves of their feather-like arms. The "feathers" consisted of branched arms lined with tube feet. The tube feet are used to move captured food toward the mouth. There are only about 600 extant species of crinoids, but they were far more numerous and abundant in ancient oceans. Many crinoids are deep-water species, but feather stars typically inhabit shallow areas, especially in substropical and tropical waters.
diff --git a/modules/m66404/index.cnxml b/modules/m66404/index.cnxml
index 94dcdab7c..2dd918559 100644
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@@ -71,7 +71,7 @@
Pain is the name given to nociception, which is the neural processing of injurious stimuli in response to tissue damage. Pain is caused by true sources of injury, such as contact with a heat source that causes a thermal burn or contact with a corrosive chemical. But pain also can be caused by harmless stimuli that mimic the action of damaging stimuli, such as contact with capsaicins, the compounds that cause peppers to taste hot and which are used in self-defense pepper sprays and certain topical medications. Peppers taste “hot” because the protein receptors that bind capsaicin open the same calcium channels that are activated by warm receptors.
Nociception starts at the sensory receptors, but pain, inasmuch as it is the perception of nociception, does not start until it is communicated to the brain. There are several nociceptive pathways to and through the brain. Most axons carrying nociceptive information into the brain from the spinal cord project to the thalamus (as do other sensory neurons) and the neural signal undergoes final processing in the primary somatosensory cortex. Interestingly, one nociceptive pathway projects not to the thalamus but directly to the hypothalamus in the forebrain, which modulates the cardiovascular and neuroendocrine functions of the autonomic nervous system. Recall that threatening—or painful—stimuli stimulate the sympathetic branch of the visceral sensory system, readying a fight-or-flight response.
-View this video that animates the five phases of nociceptive pain.
+View this video that animates the five phases of nociceptive pain.
diff --git a/modules/m66405/index.cnxml b/modules/m66405/index.cnxml
index d51bb771b..c8bcf6c64 100644
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Pores in the tongue allow tastants to enter taste pores in the tongue. (credit: modification of work by Vincenzo Rizzo)
In humans, there are five primary tastes, and each taste has only one corresponding type of receptor. Thus, like olfaction, each receptor is specific to its stimulus (tastant). Transduction of the five tastes happens through different mechanisms that reflect the molecular composition of the tastant. A salty tastant (containing NaCl) provides the sodium ions (Na+) that enter the taste neurons and excite them directly. Sour tastants are acids and belong to the thermoreceptor protein family. Binding of an acid or other sour-tasting molecule triggers a change in the ion channel and these increase hydrogen ion (H+) concentrations in the taste neurons, thus depolarizing them. Sweet, bitter, and umami tastants require a G-protein coupled receptor. These tastants bind to their respective receptors, thereby exciting the specialized neurons associated with them.Both tasting abilities and sense of smell change with age. In humans, the senses decline dramatically by age 50 and continue to decline. A child may find a food to be too spicy, whereas an elderly person may find the same food to be bland and unappetizing.
-View this animation that shows how the sense of taste works.
+View this animation that shows how the sense of taste works.
diff --git a/modules/m66407/index.cnxml b/modules/m66407/index.cnxml
index 328d687e7..035034f93 100644
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The hair cell is a mechanoreceptor with an array of stereocilia emerging from its apical surface. The stereocilia are tethered together by proteins that open ion channels when the array is bent toward the tallest member of their array, and closed when the array is bent toward the shortest member of their array.
The hair cells are arranged on the basilar membrane in an orderly way. The basilar membrane vibrates in different regions, according to the frequency of the sound waves impinging on it. Likewise, the hair cells that lay above it are most sensitive to a specific frequency of sound waves. Hair cells can respond to a small range of similar frequencies, but they require stimulation of greater intensity to fire at frequencies outside of their optimal range. The difference in response frequency between adjacent inner hair cells is about 0.2 percent. Compare that to adjacent piano strings, which are about six percent different. Place theory, which is the model for how biologists think pitch detection works in the human ear, states that high frequency sounds selectively vibrate the basilar membrane of the inner ear near the entrance port (the oval window). Lower frequencies travel farther along the membrane before causing appreciable excitation of the membrane. The basic pitch-determining mechanism is based on the location along the membrane where the hair cells are stimulated. The place theory is the first step toward an understanding of pitch perception. Considering the extreme pitch sensitivity of the human ear, it is thought that there must be some auditory “sharpening” mechanism to enhance the pitch resolution.When sound waves produce fluid waves inside the cochlea, the basilar membrane flexes, bending the stereocilia that attach to the tectorial membrane. Their bending results in action potentials in the hair cells, and auditory information travels along the neural endings of the bipolar neurons of the hair cells (collectively, the auditory nerve) to the brain. When the hairs bend, they release an excitatory neurotransmitter at a synapse with a sensory neuron, which then conducts action potentials to the central nervous system. The cochlear branch of the vestibulocochlear cranial nerve sends information on hearing. The auditory system is very refined, and there is some modulation or “sharpening” built in. The brain can send signals back to the cochlea, resulting in a change of length in the outer hair cells, sharpening or dampening the hair cells’ response to certain frequencies.
-Watch an animation of sound entering the outer ear, moving through the ear structure, stimulating cochlear nerve impulses, and eventually sending signals to the temporal lobe.
+Watch an animation of sound entering the outer ear, moving through the ear structure, stimulating cochlear nerve impulses, and eventually sending signals to the temporal lobe.Higher ProcessingThe inner hair cells are most important for conveying auditory information to the brain. About 90 percent of the afferent neurons carry information from inner hair cells, with each hair cell synapsing with 10 or so neurons. Outer hair cells connect to only 10 percent of the afferent neurons, and each afferent neuron innervates many hair cells. The afferent, bipolar neurons that convey auditory information travel from the cochlea to the medulla, through the pons and midbrain in the brainstem, finally reaching the primary auditory cortex in the temporal lobe.
@@ -73,7 +73,7 @@
Higher ProcessingHair cells from the utricle, saccule, and semicircular canals also communicate through bipolar neurons to the cochlear nucleus in the medulla. Cochlear neurons send descending projections to the spinal cord and ascending projections to the pons, thalamus, and cerebellum. Connections to the cerebellum are important for coordinated movements. There are also projections to the temporal cortex, which account for feelings of dizziness; projections to autonomic nervous system areas in the brainstem, which account for motion sickness; and projections to the primary somatosensory cortex, which monitors subjective measurements of the external world and self-movement. People with lesions in the vestibular area of the somatosensory cortex see vertical objects in the world as being tilted. Finally, the vestibular signals project to certain optic muscles to coordinate eye and head movements.
-Click through this interactive tutorial to review the parts of the ear and how they function to process sound.
+Click through this interactive tutorial to review the parts of the ear and how they function to process sound.
diff --git a/modules/m66408/index.cnxml b/modules/m66408/index.cnxml
index 06cb12a4f..c0a18e61a 100644
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Rods and cones are photoreceptors in the retina. Rods respond in low light and can detect only shades of gray. Cones respond in intense light and are responsible for color vision. (credit: modification of work by Piotr Sliwa)
The fovea is the region in the center back of the eye that is responsible for acute vision. The fovea has a high density of cones. When you bring your gaze to an object to examine it intently in bright light, the eyes orient so that the object’s image falls on the fovea. However, when looking at a star in the night sky or other object in dim light, the object can be better viewed by the peripheral vision because it is the rods at the edges of the retina, rather than the cones at the center, that operate better in low light. In humans, cones far outnumber rods in the fovea.
-Review the anatomical structure of the eye, clicking on each part to practice identification.
+Review the anatomical structure of the eye, clicking on each part to practice identification.Transduction of Light
@@ -89,7 +89,7 @@
Once in the brain, visual information is processed in several places, and its routes reflect the complexity and importance of visual information to humans and other animals. One route takes the signals to the thalamus, which serves as the routing station for all incoming sensory impulses except olfaction. In the thalamus, the magnocellular and parvocellular distinctions remain intact, and there are different layers of the thalamus dedicated to each. When visual signals leave the thalamus, they travel to the primary visual cortex at the rear of the brain. From the visual cortex, the visual signals travel in two directions. One stream that projects to the parietal lobe, in the side of the brain, carries magnocellular (“where”) information. A second stream projects to the temporal lobe and carries both magnocellular (“where”) and parvocellular (“what”) information.Another important visual route is a pathway from the retina to the superior colliculus in the midbrain, where eye movements are coordinated and integrated with auditory information. Finally, there is the pathway from the retina to the suprachiasmatic nucleus (SCN) of the hypothalamus. The SCN is a cluster of cells that is considered to be the body’s internal clock, which controls our circadian (day-long) cycle. The SCN sends information to the pineal gland, which is important in sleep/wake patterns and annual cycles.
-View this interactive presentation to review what you have learned about how vision functions.
+View this interactive presentation to review what you have learned about how vision functions.Section SummaryVision is the only photo responsive sense. Visible light travels in waves and is a very small slice of the electromagnetic radiation spectrum. Light waves differ based on their frequency (wavelength = hue) and amplitude (intensity = brightness).
diff --git a/modules/m66410/index.cnxml b/modules/m66410/index.cnxml
index a76f0ac92..60ab18190 100644
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Ecology is the study of the interactions of living organisms with their environment. One core goal of ecology is to understand the distribution and abundance of living things in the physical environment. Attainment of this goal requires the integration of scientific disciplines inside and outside of biology, such as mathematics, statistics, biochemistry, molecular biology, physiology, evolution, biodiversity, geology, and climatology.
-Climate change can alter where organisms live, which can sometimes directly affect human health. Watch the PBS video “Feeling the Effects of Climate Change” in which researchers discover a pathogenic organism living far outside of its normal range.
+Climate change can alter where organisms live, which can sometimes directly affect human health. Watch the PBS video “Feeling the Effects of Climate Change” in which researchers discover a pathogenic organism living far outside of its normal range.Levels of Ecological Study
@@ -68,7 +68,7 @@ A career in ecology contributes to many facets of human society. Understanding e
-Visit this site to see Stephen Wing, a marine ecologist from the University of Otago, discuss the role of an ecologist and the types of issues ecologists explore.
+Visit this site to see Stephen Wing, a marine ecologist from the University of Otago, discuss the role of an ecologist and the types of issues ecologists explore.
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index 2c0788961..3692b486f 100644
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Sometimes ecologists discover unique patterns of species distribution by determining where species are not found. Despite being tropical, Hawaii, for example, has no native land species of reptiles or amphibians, only a few native species of butterflies, and only one native terrestrial mammal, the hoary bat. Most of New Guinea, as another example, lacks placental mammals.
-Check out this video to observe a platypus swimming in its natural habitat in New South Wales, Australia.
+Check out this video to observe a platypus swimming in its natural habitat in New South Wales, Australia.Like animals, plants can be endemic or generalists: endemic plants are found only on specific regions of the Earth, while generalists are found on many regions. Isolated land masses—such as Australia, Hawaii, and Madagascar—often have large numbers of endemic plant species. Some of these plants are endangered due to human activity. The forest gardenia (Gardenia brighamii), for instance, is endemic to Hawaii; only an estimated 15–20 trees are thought to exist ().
diff --git a/modules/m66417/index.cnxml b/modules/m66417/index.cnxml
index ab54c6388..37099cdb5 100644
--- a/modules/m66417/index.cnxml
+++ b/modules/m66417/index.cnxml
@@ -53,7 +53,7 @@
Coral ReefsCoral reefs are ocean ridges formed by marine invertebrates, comprising mostly cnidarians and molluscs, living in warm shallow waters within the photic zone of the ocean. They are found within 30˚ north and south of the equator. The Great Barrier Reef is perhaps the best-known and largest reef system in the world—visible from the International Space Station! This massive and ancient reef is located several miles off the northeastern coast of Australia. Other coral reef systems are fringing islands, which are directly adjacent to land, or atolls, which are circular reef systems surrounding a former landmass that is now underwater. The coral organisms (members of phylum Cnidaria) are colonies of saltwater polyps that secrete a calcium carbonate skeleton. These calcium-rich skeletons slowly accumulate, forming the underwater reef (). Corals found in shallower waters (at a depth of approximately 60 m or about 200 ft) have a mutualistic relationship with photosynthetic unicellular algae. The relationship provides corals with the majority of the nutrition and the energy they require. The waters in which these corals live are nutritionally poor and, without this mutualism, it would not be possible for large corals to grow. Some corals living in deeper and colder water do not have a mutualistic relationship with algae; these corals attain energy and nutrients using stinging cells called cnidocytes on their tentacles to capture prey.
-Watch this National Oceanic and Atmospheric Administration (NOAA) video to see marine ecologist Dr. Peter Etnoyer discuss his research on coral organisms.
+Watch this National Oceanic and Atmospheric Administration (NOAA) video to see marine ecologist Dr. Peter Etnoyer discuss his research on coral organisms.It is estimated that more than 4,000 fish species inhabit coral reefs. These fishes can feed on coral, the cryptofauna (invertebrates found within the calcium carbonate substrate of the coral reefs), or the seaweed and algae that are associated with the coral. In addition, some fish species inhabit the boundaries of a coral reef; these species include predators, herbivores, and planktivores, which consume planktonic organisms such as bacteria, archaea, algae, and protists floating in the pelagic zone.
diff --git a/modules/m66419/index.cnxml b/modules/m66419/index.cnxml
index 0f88df942..b11344d53 100644
--- a/modules/m66419/index.cnxml
+++ b/modules/m66419/index.cnxml
@@ -74,7 +74,7 @@
Global warming has been associated with at least one planet-wide extinction event during the geological past. The Permian extinction event occurred about 251 million years ago toward the end of the roughly 50-million-year-long geological time span known as the Permian period. This geologic time period was one of the three warmest periods in Earth’s geologic history. Scientists estimate that approximately 70 percent of the terrestrial plant and animal species and 84 percent of marine species became extinct, vanishing forever near the end of the Permian period.Organisms that had adapted to wet and warm climatic conditions, such as annual rainfall of 300–400 cm (118–157 in) and 20 °C–30 °C (68 °F–86 °F) in the tropical wet forest, may not have been able to survive the Permian climate change.
-Watch this NASA video to discover the mixed effects of global warming on plant growth. While scientists found that warmer temperatures in the 1980s and 1990s caused an increase in plant productivity, this advantage has since been counteracted by more frequent droughts.
+Watch this NASA video to discover the mixed effects of global warming on plant growth. While scientists found that warmer temperatures in the 1980s and 1990s caused an increase in plant productivity, this advantage has since been counteracted by more frequent droughts.
diff --git a/modules/m66420/index.cnxml b/modules/m66420/index.cnxml
index e3f3bcfa0..a71e874f8 100644
--- a/modules/m66420/index.cnxml
+++ b/modules/m66420/index.cnxml
@@ -110,7 +110,7 @@
Low-growing plants such as shrub willow dominate the tundra landscape, shown here in the Arctic National Wildlife Refuge. (credit: USFWS Arctic National Wildlife Refuge)
-Watch this Assignment Discovery: Biomes video for an overview of biomes. To explore further, select one of the biomes on the extended playlist: desert, savanna, temperate forest, temperate grassland, tropic, tundra.
+Watch this Assignment Discovery: Biomes video for an overview of biomes. To explore further, select one of the biomes on the extended playlist: desert, savanna, temperate forest, temperate grassland, tropic, tundra.
diff --git a/modules/m66427/index.cnxml b/modules/m66427/index.cnxml
index 6865fe810..53fd5be37 100644
--- a/modules/m66427/index.cnxml
+++ b/modules/m66427/index.cnxml
@@ -121,7 +121,7 @@
-
The Human Genome Project was a 13-year collaborative effort among researchers working in several different science fields. Researchers completed the project, which sequenced the entire human genome, in 2003. (credit: the U.S. Department of Energy Genome Programs (http://genomics.energy.gov)
While scientists usually carefully plan research efforts in both basic science and applied science, note that some discoveries are made by serendipity, that is, by means of a fortunate accident or a lucky surprise. Scottish biologist Alexander Fleming discovered penicillin when he accidentally left a petri dish of Staphylococcus bacteria open. An unwanted mold grew on the dish, killing the bacteria. Fleming's curiosity to investigate the reason behind the bacterial death, followed by his experiments, led to the discovery of the antibiotic penicillin, which is produced by the fungus Penicillium. Even in the highly organized world of science, luck—when combined with an observant, curious mind—can lead to unexpected breakthroughs.
+
The Human Genome Project was a 13-year collaborative effort among researchers working in several different science fields. Researchers completed the project, which sequenced the entire human genome, in 2003. (credit: the U.S. Department of Energy Genome Programs (http://genomics.energy.gov)
While scientists usually carefully plan research efforts in both basic science and applied science, note that some discoveries are made by serendipity, that is, by means of a fortunate accident or a lucky surprise. Scottish biologist Alexander Fleming discovered penicillin when he accidentally left a petri dish of Staphylococcus bacteria open. An unwanted mold grew on the dish, killing the bacteria. Fleming's curiosity to investigate the reason behind the bacterial death, followed by his experiments, led to the discovery of the antibiotic penicillin, which is produced by the fungus Penicillium. Even in the highly organized world of science, luck—when combined with an observant, curious mind—can lead to unexpected breakthroughs.Reporting Scientific Work
diff --git a/modules/m66428/index.cnxml b/modules/m66428/index.cnxml
index 3edc40531..5dfe50d00 100644
--- a/modules/m66428/index.cnxml
+++ b/modules/m66428/index.cnxml
@@ -36,7 +36,7 @@
Organisms respond to diverse stimuli. For example, plants can bend toward a source of light, climb on fences and walls, or respond to touch (). Even tiny bacteria can move toward or away from chemicals (a process called chemotaxis) or light (phototaxis). Movement toward a stimulus is a positive response, while movement away from a stimulus is a negative response.
-Watch this video to see how plants respond to a stimulus—from opening to light, to wrapping a tendril around a branch, to capturing prey.
+Watch this video to see how plants respond to a stimulus—from opening to light, to wrapping a tendril around a branch, to capturing prey.Reproduction
@@ -80,7 +80,7 @@
All molecules, including this DNA molecule, are comprised of atoms. (credit: “brian0918”/Wikimedia Commons)
-Watch this video that animates the three-dimensional structure of the DNA molecule in .
+Watch this video that animates the three-dimensional structure of the DNA molecule in .Some cells contain aggregates of macromolecules surrounded by membranes. We call these organelles. Organelles are small structures that exist within cells. Examples of organelles include mitochondria and chloroplasts, which carry out indispensable functions: mitochondria process energy to power the cell, while chloroplasts enable green plants to utilize the energy in sunlight to make sugars. All living things are made of cells. The cell itself is the smallest fundamental unit of structure and function in living organisms. (This requirement is why scientists do not consider viruses living: they are not made of cells. To make new viruses, they have to invade and hijack the reproductive mechanism of a living cell. Only then can they obtain the materials they need to reproduce.) Some organisms consist of a single cell and others are multicellular. Scientists classify cells as prokaryotic or eukaryotic. Prokaryotes are single-celled or colonial organisms that do not have membrane-bound nuclei. In contrast, the cells of eukaryotes do have membrane-bound organelles and a membrane-bound nucleus.In larger organisms, cells combine to make tissues, which are groups of similar cells carrying out similar or related functions. Organs are collections of tissues grouped together performing a common function. Organs are present not only in animals but also in plants. An organ system is a higher level of organization that consists of functionally related organs. Mammals have many organ systems. For instance, the circulatory system transports blood through the body and to and from the lungs. It includes organs such as the heart and blood vessels. Organisms are individual living entities. For example, each tree in a forest is an organism. Single-celled prokaryotes and single-celled eukaryotes are also organisms, which biologists typically call microorganisms.
diff --git a/modules/m66434/index.cnxml b/modules/m66434/index.cnxml
index 2f6c7af7e..15264872f 100644
--- a/modules/m66434/index.cnxml
+++ b/modules/m66434/index.cnxml
@@ -36,7 +36,7 @@ Tag, A. and Hawkins, A. Department of Biology, Texas A&M University
Hydrogen bonding makes ice less dense than liquid water. The (a) lattice structure of ice makes it less dense than the liquid water's freely flowing molecules, enabling it to (b) float on water. (credit a: modification of work by Jane Whitney, image created using Visual Molecular Dynamics (VMD) softwareW. Humphrey W., A. Dalke, and K. Schulten, “VMD—Visual Molecular Dynamics,” Journal of Molecular Graphics 14 (1996): 33-38.; credit b: modification of work by Carlos Ponte)
-Click here to see a 3-D animation of an ice lattice structure.
+Click here to see a 3-D animation of an ice lattice structure.Water’s High Heat CapacityWater’s high heat capacity is a property that hydrogen bonding among water molecules causes. Water has the highest specific heat capacity of any liquid. We define specific heat as the amount of heat one gram of a substance must absorb or lose to change its temperature by one degree Celsius. For water, this amount is one calorie. It therefore takes water a long time to heat and a long time to cool. In fact, water's specific heat capacity is about five times more than that of sand. This explains why the land cools faster than the sea. Due to its high heat capacity, warm blooded animals use water to more evenly disperse heat in their bodies: it acts in a similar manner to a car’s cooling system, transporting heat from warm places to cool places, causing the body to maintain a more even temperature.
@@ -126,7 +126,7 @@ Tag, A. and Hawkins, A. Department of Biology, Texas A&M UniversityThis diagram shows the body’s buffering of blood pH levels. The blue arrows show the process of raising pH as more CO2 is made. The purple arrows indicate the reverse process: the lowering of pH as more bicarbonate is created.Other examples of buffers are antacids that some people use to combat excess stomach acid. Many of these over-the-counter medications work in the same way as blood buffers, usually with at least one ion capable of absorbing hydrogen and moderating pH, bringing relief to those who suffer “heartburn” after eating. Water's unique properties that contribute to this capacity to balance pH—as well as water’s other characteristics—are essential to sustaining life on Earth.
-To learn more about water, visit the U.S. Geological Survey Water Science for Schools All About Water! website.
+To learn more about water, visit the U.S. Geological Survey Water Science for Schools All About Water! website.Section SummaryWater has many properties that are critical to maintaining life. It is a polar molecule, allowing for forming hydrogen bonds. Hydrogen bonds allow ions and other polar molecules to dissolve in water. Therefore, water is an excellent solvent. The hydrogen bonds between water molecules cause the water to have a high heat capacity, meaning it takes considerable added heat to raise its temperature. As the temperature rises, the hydrogen bonds between water continually break and form anew. This allows for the overall temperature to remain stable, although energy is added to the system. Water also exhibits a high heat of vaporization, which is key to how organisms cool themselves by evaporating sweat. Water’s cohesive forces allow for the property of surface tension; whereas, we see its adhesive properties as water rises inside capillary tubes. The pH value is a measure of hydrogen ion concentration in a solution and is one of many chemical characteristics that is highly regulated in living organisms through homeostasis. Acids and bases can change pH values, but buffers tend to moderate the changes they cause. These properties of water are intimately connected to the biochemical and physical processes performed by living organisms, and life would be very different if these properties were altered, if it could exist at all.
diff --git a/modules/m66438/index.cnxml b/modules/m66438/index.cnxml
index e1131f3aa..bd551e9c6 100644
--- a/modules/m66438/index.cnxml
+++ b/modules/m66438/index.cnxml
@@ -31,7 +31,7 @@
In the hydrolysis reaction here, the disaccharide maltose breaks down to form two glucose monomers by adding a water molecule. Note that this reaction is the reverse of the synthesis reaction in .
Dehydration and hydrolysis reactions are catalyzed, or “sped up,” by specific enzymes; dehydration reactions involve the formation of new bonds, requiring energy, while hydrolysis reactions break bonds and release energy. These reactions are similar for most macromolecules, but each monomer and polymer reaction is specific for its class. For example, catalytic enzymes in the digestive system hydrolyze or break down the food we ingest into smaller molecules. This allows cells in our body to easily absorb nutrients in the intestine. A specific enzyme breaks down each macromolecule. For instance, amylase, sucrase, lactase, or maltase break down carbohydrates. Enzymes called proteases, such as pepsin and peptidase, and hydrochloric acid break down proteins. Lipases break down lipids. These broken down macromolecules provide energy for cellular activities.
-Visit this site to see visual representations of dehydration synthesis and hydrolysis.
+Visit this site to see visual representations of dehydration synthesis and hydrolysis.Section Summary
diff --git a/modules/m66440/index.cnxml b/modules/m66440/index.cnxml
index 5cb2c1246..42cce27d6 100644
--- a/modules/m66440/index.cnxml
+++ b/modules/m66440/index.cnxml
@@ -86,7 +86,7 @@ found in plants. Credit: Ryan, K. Rao, A. and Hawkins, A. Department of Biology,
Benefits of CarbohydratesAre carbohydrates good for you? Some people believe that carbohydrates are bad and they should avoid them. Some diets completely forbid carbohydrate consumption, claiming that a low-carbohydrate diet helps people to lose weight faster. However, carbohydrates have been an important part of the human diet for thousands of years. Artifacts from ancient civilizations show the presence of wheat, rice, and corn in our ancestors’ storage areas.As part of a well balanced diet, we should supplement carbohydrates with proteins, vitamins, and fats. Calorie-wise, a gram of carbohydrate provides 4.3 Kcal. For comparison, fats provide 9 Kcal/g, a less desirable ratio. Carbohydrates contain soluble and insoluble elements. The insoluble part, fiber, is mostly cellulose. Fiber has many uses. It promotes regular bowel movement by adding bulk, and it regulates the blood glucose consumption rate. Fiber also helps to remove excess cholesterol from the body. Fiber binds to the cholesterol in the small intestine, then attaches to the cholesterol and prevents the cholesterol particles from entering the bloodstream. Cholesterol then exits the body via the feces. Fiber-rich diets also have a protective role in reducing the occurrence of colon cancer. In addition, a meal containing whole grains and vegetables gives a feeling of fullness. As an immediate source of energy, glucose breaks down during the cellular respiration process, which produces ATP, the cell's energy currency. Without consuming carbohydrates, we reduce the availability of “instant energy”. Eliminating carbohydrates from the diet may be necessary for some people, but such a step may not be healthy for everyone.
-For an additional perspective on carbohydrates, explore “Biomolecules: the Carbohydrates” through this interactive animation.
+For an additional perspective on carbohydrates, explore “Biomolecules: the Carbohydrates” through this interactive animation.Section Summary
diff --git a/modules/m66441/index.cnxml b/modules/m66441/index.cnxml
index 5d80c330b..1274a5c55 100644
--- a/modules/m66441/index.cnxml
+++ b/modules/m66441/index.cnxml
@@ -104,7 +104,7 @@
Cholesterol is the most common steroid. The liver synthesizes cholesterol and is the precursor to many steroid hormones such as testosterone and estradiol, which gonads and endocrine glands secrete. It is also the precursor to Vitamin D. Cholesterol is also the precursor of bile salts, which help emulsifying fats and their subsequent absorption by cells. Although lay people often speak negatively about cholesterol, it is necessary for the body's proper functioning. Sterols (cholesterol in animal cells, phytosterol in plants) are components of the plasma membrane of cells and are found within the phospholipid bilayer.
-For an additional perspective on lipids, watch this video about types of fat.
+For an additional perspective on lipids, watch this video about types of fat.Section SummaryLipids are a class of macromolecules that are nonpolar and hydrophobic in nature. Major types include fats and oils, waxes, phospholipids, and steroids. Fats are a stored form of energy and are also known as triacylglycerols or triglycerides. Fats are comprised of fatty acids and either glycerol or sphingosine. Fatty acids may be unsaturated or saturated, depending on the presence or absence of double bonds in the hydrocarbon chain. If only single bonds are present, they are saturated fatty acids. Unsaturated fatty acids may have one or more double bonds in the hydrocarbon chain. Phospholipids comprise the membrane's matrix. They have a glycerol or sphingosine backbone to which two fatty acid chains and a phosphate-containing group are attached. Steroids are another class of lipids. Their basic structure has four fused carbon rings. Cholesterol is a type of steroid and is an important constituent of the plasma membrane, where it helps to maintain the membrane's fluid nature. It is also the precursor of steroid hormones such as testosterone.
diff --git a/modules/m66442/index.cnxml b/modules/m66442/index.cnxml
index d6306357f..892c7531f 100644
--- a/modules/m66442/index.cnxml
+++ b/modules/m66442/index.cnxml
@@ -70,7 +70,7 @@
Peptide bond formation is a dehydration synthesis reaction. The carboxyl group of one amino acid is linked to the incoming amino acid's amino group. In the process, it releases a water molecule.
The products that such linkages form are peptides. As more amino acids join to this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end is called the N terminal, or the amino terminal, and the other end has a free carboxyl group, also called the C or carboxyl terminal. While the terms polypeptide and protein are sometimes used interchangeably, a polypeptide is technically a polymer of amino acids, whereas the term protein is used for a polypeptide or polypeptides that have combined together, often have bound non-peptide prosthetic groups, have a distinct shape, and have a unique function. After protein synthesis (translation), most proteins are modified. These are known as post-translational modifications. They may undergo cleavage, phosphorylation, or may require adding other chemical groups. Only after these modifications is the protein completely functional.
-Click through the steps of protein synthesis in this interactive tutorial.
+Click through the steps of protein synthesis in this interactive tutorial.The Evolutionary Significance of Cytochrome cCytochrome c is an important component of the electron transport chain, a part of cellular respiration, and it is normally located in the cellular organelle, the mitochondrion. This protein has a heme prosthetic group, and the heme's central ion alternately reduces and oxidizes during electron transfer. Because this essential protein’s role in producing cellular energy is crucial, it has changed very little over millions of years. Protein sequencing has shown that there is a considerable amount of cytochrome c amino acid sequence homology among different species. In other words, we can assess evolutionary kinship by measuring the similarities or differences among various species’ DNA or protein sequences.
@@ -135,7 +135,7 @@ A&M University.Each protein has its own unique sequence and shape that chemical interactions hold together. If the protein is subject to changes in temperature, pH, or exposure to chemicals, the protein structure may change, losing its shape without losing its primary sequence in what scientists call denaturation. Denaturation is often reversible because the polypeptide's primary structure is conserved in the process if the denaturing agent is removed, allowing the protein to resume its function. Sometimes denaturation is irreversible, leading to loss of function. One example of irreversible protein denaturation is frying an egg. The albumin protein in the liquid egg white denatures when placed in a hot pan. Not all proteins denature at high temperatures. For instance, bacteria that survive in hot springs have proteins that function at temperatures close to boiling. The stomach is also very acidic, has a low pH, and denatures proteins as part of the digestion process; however, the stomach's digestive enzymes retain their activity under these conditions.Protein folding is critical to its function. Scientists originally thought that the proteins themselves were responsible for the folding process. Only recently researchers discovered that often they receive assistance in the folding process from protein helpers, or chaperones (or chaperonins) that associate with the target protein during the folding process. They act by preventing polypeptide aggregation that comprise the complete protein structure, and they disassociate from the protein once the target protein is folded.
-For an additional perspective on proteins, view this animation called “Biomolecules: The Proteins.”
+For an additional perspective on proteins, view this animation called “Biomolecules: The Proteins.”Section Summary
diff --git a/modules/m66443/index.cnxml b/modules/m66443/index.cnxml
index f150cbc35..7072a5dac 100644
--- a/modules/m66443/index.cnxml
+++ b/modules/m66443/index.cnxml
@@ -81,7 +81,7 @@
Even though the RNA is single stranded, most RNA types show extensive intramolecular base pairing between complementary sequences, creating a predictable three-dimensional structure essential for their function.As you have learned, information flow in an organism takes place from DNA to RNA to protein. DNA dictates the structure of mRNA in a process scientists call transcription, and RNA dictates the protein's structure in a process scientists call translation. This is the Central Dogma of Life, which holds true for all organisms; however, exceptions to the rule occur in connection with viral infections.
-To learn more about DNA, explore the Howard Hughes Medical Institute BioInteractive animations on the topic of DNA.
+To learn more about DNA, explore the Howard Hughes Medical Institute BioInteractive animations on the topic of DNA.Section Summary
diff --git a/modules/m66445/index.cnxml b/modules/m66445/index.cnxml
index fdfbe2f17..29b757bdf 100644
--- a/modules/m66445/index.cnxml
+++ b/modules/m66445/index.cnxml
@@ -39,7 +39,7 @@
(a) These Salmonella bacteria appear as tiny purple dots when viewed with a light microscope. (b) This scanning electron microscope micrograph shows Salmonella bacteria (in red) invading human cells (yellow). Even though subfigure (b) shows a different Salmonella specimen than subfigure (a), you can still observe the comparative increase in magnification and detail. (credit a: modification of work by CDC/Armed Forces Institute of Pathology, Charles N. Farmer, Rocky Mountain Laboratories; credit b: modification of work by NIAID, NIH; scale-bar data from Matt Russell)
-For another perspective on cell size, try the HowBig interactive at this site.
+For another perspective on cell size, try the HowBig interactive at this site.
diff --git a/modules/m66452/index.cnxml b/modules/m66452/index.cnxml
index 5d051c1e8..43d770626 100644
--- a/modules/m66452/index.cnxml
+++ b/modules/m66452/index.cnxml
@@ -41,7 +41,7 @@
The smooth endoplasmic reticulum (SER) is continuous with the RER but has few or no ribosomes on its cytoplasmic surface (). SER functions include synthesis of carbohydrates, lipids, and steroid hormones; detoxification of medications and poisons; and storing calcium ions.In muscle cells, a specialized SER, the sarcoplasmic reticulum, is responsible for storing calcium ions that are needed to trigger the muscle cells' coordinated contractions.
-You can watch an excellent animation of the endomembrane system here. At the end of the animation, there is a short self-assessment.
+You can watch an excellent animation of the endomembrane system here. At the end of the animation, there is a short self-assessment.CardiologistHeart disease is the leading cause of death in the United States. This is primarily due to our sedentary lifestyle and our high trans-fat diets.Heart failure is just one of many disabling heart conditions. Heart failure does not mean that the heart has stopped working. Rather, it means that the heart can’t pump with sufficient force to transport oxygenated blood to all the vital organs. Left untreated, heart failure can lead to kidney failure and other organ failure.
diff --git a/modules/m66455/index.cnxml b/modules/m66455/index.cnxml
index aebcf6ef3..abcccc729 100644
--- a/modules/m66455/index.cnxml
+++ b/modules/m66455/index.cnxml
@@ -63,7 +63,7 @@
Gap junctions develop when a set of six proteins (connexins) in the plasma membrane arrange themselves in an elongated donut-like configuration - a connexon. When the connexon's pores (“doughnut holes”) in adjacent animal cells align, a channel between the two cells forms. Gap junctions are particularly important in cardiac muscle. The electrical signal for the muscle to contract passes efficiently through gap junctions, allowing the heart muscle cells to contract in tandem.
-To conduct a virtual microscopy lab and review the parts of a cell, work through the steps of this interactive assignment.
+To conduct a virtual microscopy lab and review the parts of a cell, work through the steps of this interactive assignment.
diff --git a/modules/m66459/index.cnxml b/modules/m66459/index.cnxml
index 991c8175b..ac6a69ee6 100644
--- a/modules/m66459/index.cnxml
+++ b/modules/m66459/index.cnxml
@@ -28,7 +28,7 @@
The molecules in gasoline contain chemical energy within the chemical bonds. This energy transforms into kinetic energy that allows a car to race on a racetrack. (credit “car”: modification of work by Russell Trow)
-Visit this site and select “A simple pendulum” on the menu (under “Harmonic Motion”) to see the shifting kinetic (K) and potential energy (U) of a pendulum in motion.
+Visit this site and select “A simple pendulum” on the menu (under “Harmonic Motion”) to see the shifting kinetic (K) and potential energy (U) of a pendulum in motion.
@@ -71,7 +71,7 @@ University.There is another important concept that we must consider regarding endergonic and exergonic reactions. Even exergonic reactions require a small amount of energy input before they can proceed with their energy-releasing steps. These reactions have a net release of energy, but still require some initial energy. Scientists call this small amount of energy input necessary for all chemical reactions to occur the activation energy (or free energy of activation) abbreviated as EA ().Why would an energy-releasing, negative ∆G reaction actually require some energy to proceed? The reason lies in the steps that take place during a chemical reaction. During chemical reactions, certain chemical bonds break and new ones form. For example, when a glucose molecule breaks down, bonds between the molecule's carbon atoms break. Since these are energy-storing bonds, they release energy when broken. However, to get them into a state that allows the bonds to break, the molecule must be somewhat contorted. A small energy input is required to achieve this contorted state. This contorted state is the transition state, and it is a high-energy, unstable state. For this reason, reactant molecules do not last long in their transition state, but very quickly proceed to the chemical reaction's next steps. Free energy diagrams illustrate the energy profiles for a given reaction. Whether the reaction is exergonic or endergonic determines whether the products in the diagram will exist at a lower or higher energy state than both the reactants and the products. However, regardless of this measure, the transition state of the reaction exists at a higher energy state than the reactants, and thus, EA is always positive.
-Watch an animation of the move from free energy to transition state at this site.
+Watch an animation of the move from free energy to transition state at this site.From where does the activation energy that chemical reactants require come? The activation energy's required source to push reactions forward is typically heat energy from the surroundings. Heat energy (the total bond energy of reactants or products in a chemical reaction) speeds up the molecule's motion, increasing the frequency and force with which they collide. It also moves atoms and bonds within the molecule slightly, helping them reach their transition state. For this reason, heating a system will cause chemical reactants within that system to react more frequently. Increasing the pressure on a system has the same effect. Once reactants have absorbed enough heat energy from their surroundings to reach the transition state, the reaction will proceed.The activation energy of a particular reaction determines the rate at which it will proceed. The higher the activation energy, the slower the chemical reaction. The example of iron rusting illustrates an inherently slow reaction. This reaction occurs slowly over time because of its high EA. Additionally, burning many fuels, which is strongly exergonic, will take place at a negligible rate unless sufficient heat from a spark overcomes their activation energy. However, once they begin to burn, the chemical reactions release enough heat to continue the burning process, supplying the activation energy for surrounding fuel molecules. Like these reactions outside of cells, the activation energy for most cellular reactions is too high for heat energy to overcome at efficient rates. In other words, in order for important cellular reactions to occur at appreciable rates (number of reactions per unit time), their activation energies must be lowered (). Scientist refer to this as catalysis. This is a very good thing as far as living cells are concerned. Important macromolecules, such as proteins, DNA, and RNA, store considerable energy, and their breakdown is exergonic. If cellular temperatures alone provided enough heat energy for these exergonic reactions to overcome their activation barriers, the cell's essential components would disintegrate.
diff --git a/modules/m66462/index.cnxml b/modules/m66462/index.cnxml
index e012a0307..466461c9e 100644
--- a/modules/m66462/index.cnxml
+++ b/modules/m66462/index.cnxml
@@ -56,7 +56,7 @@
Often during cellular metabolic reactions, such as nutrient synthesis and breakdown, certain molecules must alter slightly in their conformation to become substrates for the next step in the reaction series. One example is during the very first steps of cellular respiration, when a sugar glucose molecule breaks down in the process of glycolysis. In the first step, ATP is required to phosphorylate glucose, creating a high-energy but unstable intermediate. This phosphorylation reaction powers a conformational change that allows the phosphorylated glucose molecule to convert to the phosphorylated sugar fructose. Fructose is a necessary intermediate for glycolysis to move forward. Here, ATP hydrolysis' exergonic reaction couples with the endergonic reaction of converting glucose into a phosphorylated intermediate in the pathway. Once again, the energy released by breaking a phosphate bond within ATP was used for phosphorylyzing another molecule, creating an unstable intermediate and powering an important conformational change.
-See an animation of the ATP-producing glycolysis process at this site.
+See an animation of the ATP-producing glycolysis process at this site.Section SummaryATP is the primary energy-supplying molecule for living cells. ATP is comprised of a nucleotide, a five-carbon sugar, and three phosphate groups. The bonds that connect the phosphates (phosphoanhydride bonds) have high-energy content. The energy released from ATP hydrolysis into ADP + Pi performs cellular work. Cells use ATP to perform work by coupling ATP hydrolysis' exergonic reaction with endergonic reactions. ATP donates its phosphate group to another molecule via phosphorylation. The phosphorylated molecule is at a higher-energy state and is less stable than its unphosphorylated form, and this added energy from phosphate allows the molecule to undergo its endergonic reaction.
diff --git a/modules/m66463/index.cnxml b/modules/m66463/index.cnxml
index 71a23deba..073001495 100644
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@@ -26,7 +26,7 @@
Induced Fit and Enzyme FunctionFor many years, scientists thought that enzyme-substrate binding took place in a simple “lock-and-key” fashion. This model asserted that the enzyme and substrate fit together perfectly in one instantaneous step. However, current research supports a more refined view scientists call induced fit (). This model expands upon the lock-and-key model by describing a more dynamic interaction between enzyme and substrate. As the enzyme and substrate come together, their interaction causes a mild shift in the enzyme’s structure that confirms an ideal binding arrangement between the enzyme and the substrate's transition state. This ideal binding maximizes the enzyme’s ability to catalyze its reaction.
-View an induced fit animation at this website.
+View an induced fit animation at this website.
When an enzyme binds its substrate, it forms an enzyme-substrate complex. This complex lowers the reaction's activation energy and promotes its rapid progression in one of many ways. On a basic level, enzymes promote chemical reactions that involve more than one substrate by bringing the substrates together in an optimal orientation. The appropriate region (atoms and bonds) of one molecule is juxtaposed to the other molecule's appropriate region with which it must react. Another way in which enzymes promote substrate reaction is by creating an optimal environment within the active site for the reaction to occur. Certain chemical reactions might proceed best in a slightly acidic or non-polar environment. The chemical properties that emerge from the particular arrangement of amino acid residues within an active site create the perfect environment for an enzyme’s specific substrates to react.
diff --git a/modules/m66466/index.cnxml b/modules/m66466/index.cnxml
index 9a4672cfe..88b45d76b 100644
--- a/modules/m66466/index.cnxml
+++ b/modules/m66466/index.cnxml
@@ -48,7 +48,7 @@ Texas A&M University
Step 9. Enolase catalyzes the ninth step. This enzyme causes 2-phosphoglycerate to lose water from its structure; this is a dehydration reaction, resulting in the formation of a double bond that increases the potential energy in the remaining phosphate bond and produces phosphoenolpyruvate (PEP).Step 10. The last step in glycolysis is catalyzed by the enzyme pyruvate kinase (the enzyme in this case is named for the reverse reaction of pyruvate’s conversion into PEP) and results in the production of a second ATP molecule by substrate-level phosphorylation and the compound pyruvic acid (or its salt form, pyruvate). Many enzymes in enzymatic pathways are named for the reverse reactions, since the enzyme can catalyze both forward and reverse reactions (these may have been described initially by the reverse reaction that takes place in vitro, under nonphysiological conditions).
-Gain a better understanding of the breakdown of glucose by glycolysis by visiting this site to see the process in action.
+Gain a better understanding of the breakdown of glucose by glycolysis by visiting this site to see the process in action.Outcomes of Glycolysis
diff --git a/modules/m66467/index.cnxml b/modules/m66467/index.cnxml
index 7fde9dd83..c771c7760 100644
--- a/modules/m66467/index.cnxml
+++ b/modules/m66467/index.cnxml
@@ -44,7 +44,7 @@ A&M University.Step 6. Step six is a dehydrogenation process that converts succinate into fumarate. Two hydrogen atoms are transferred to FAD, reducing it to FADH2. (Note: the energy contained in the electrons of these hydrogens is insufficient to reduce NAD+ but adequate to reduce FAD.) Unlike NADH, this carrier remains attached to the enzyme and transfers the electrons to the electron transport chain directly. This process is made possible by the localization of the enzyme catalyzing this step inside the inner membrane of the mitochondrion.Step 7. Water is added by hydration to fumarate during step seven, and malate is produced. The last step in the citric acid cycle regenerates oxaloacetate by oxidizing malate. Another molecule of NADH is then produced in the process.
-View an animation of the citric acid cycle here.
+View an animation of the citric acid cycle here.Products of the Citric Acid CycleTwo carbon atoms come into the citric acid cycle from each acetyl group, representing four out of the six carbons of one glucose molecule. Two carbon dioxide molecules are released on each turn of the cycle; however, these do not necessarily contain the most recently added carbon atoms. The two acetyl carbon atoms will eventually be released on later turns of the cycle; thus, all six carbon atoms from the original glucose molecule are eventually incorporated into carbon dioxide. Each turn of the cycle forms three NADH molecules and one FADH2 molecule. These carriers will connect with the last portion of aerobic respiration, the electron transport chain, to produce ATP molecules. One GTP or ATP is also made in each cycle. Several of the intermediate compounds in the citric acid cycle can be used in synthesizing nonessential amino acids; therefore, the cycle is amphibolic (both catabolic and anabolic).
diff --git a/modules/m66469/index.cnxml b/modules/m66469/index.cnxml
index 40c60f829..8d008a75e 100644
--- a/modules/m66469/index.cnxml
+++ b/modules/m66469/index.cnxml
@@ -14,7 +14,7 @@
In aerobic respiration, the final electron acceptor is an oxygen molecule, O2. If aerobic respiration occurs, then ATP will be produced using the energy of high-energy electrons carried by NADH or FADH2 to the electron transport chain. If aerobic respiration does not occur, NADH must be reoxidized to NAD+ for reuse as an electron carrier for the glycolytic pathway to continue. How is this done? Some living systems use an organic molecule as the final electron acceptor. Processes that use an organic molecule to regenerate NAD+ from NADH are collectively referred to as fermentation. In contrast, in some living systems, the electron transport chain (ETC) uses an inorganic molecule as a final electron acceptor, which is called anaerobic cellular respiration. Both processes allow organisms to convert energy for their use in the absence of oxygen. Both methods are called anaerobic cellular respiration, in which organisms convert energy for their use in the absence of oxygen.
- Visit this site to see fermentation in action.
+ Visit this site to see fermentation in action.
diff --git a/modules/m66471/index.cnxml b/modules/m66471/index.cnxml
index 250330f88..d4b8cc1c2 100644
--- a/modules/m66471/index.cnxml
+++ b/modules/m66471/index.cnxml
@@ -37,7 +37,7 @@
Electron Transport ChainSpecific enzymes of the electron transport chain are unaffected by feedback inhibition, but the rate of electron transport through the pathway is affected by the levels of ADP and ATP. Greater ATP consumption by a cell is indicated by a buildup of ADP. As ATP usage decreases, the concentration of ADP decreases, and now, ATP begins to build up in the cell. This change in the relative concentration of ADP to ATP triggers the cell to slow down the electron transport chain.
-Visit this site to see an animation of the electron transport chain and ATP synthesis.
+Visit this site to see an animation of the electron transport chain and ATP synthesis. For a summary of feedback controls in cellular respiration, see .
Photosynthesis takes place in two stages: light-dependent reactions and the Calvin cycle. Light-dependent reactions, which take place in the thylakoid membrane, use light energy to make ATP and NADPH. The Calvin cycle, which takes place in the stroma, uses energy derived from these compounds to make G3P from CO2. Credit: Rao, A., Ryan, K., Fletcher, S., Hawkins, A. and Tag, A. Texas A&M University.
-Click the link to learn more about photosynthesis.
+Click the link to learn more about photosynthesis.Photosynthesis at the Grocery Store
diff --git a/modules/m66474/index.cnxml b/modules/m66474/index.cnxml
index 223f7631c..872814f2c 100644
--- a/modules/m66474/index.cnxml
+++ b/modules/m66474/index.cnxml
@@ -89,7 +89,7 @@ A., Fletcher, S. and Hawkins, A. Department of Biology, Texas A&M University
The reaction center of PSII (called P680) delivers its high-energy electrons, one at the time, to the primary electron acceptor, and through the electron transport chain (Pq to cytochrome complex to plastocyanine) to PSI. P680’s missing electron is replaced by extracting a low-energy electron from water; thus, water is “split” during this stage of photosynthesis, and PSII is re-reduced after every photoact. Splitting one H2O molecule releases two electrons, two hydrogen atoms, and one atom of oxygen. However, splitting two molecules is required to form one molecule of diatomic O2 gas. About 10 percent of the oxygen is used by mitochondria in the leaf to support oxidative phosphorylation. The remainder escapes to the atmosphere where it is used by aerobic organisms to support respiration.As electrons move through the proteins that reside between PSII and PSI, they lose energy. This energy is used to move hydrogen atoms from the stromal side of the membrane to the thylakoid lumen. Those hydrogen atoms, plus the ones produced by splitting water, accumulate in the thylakoid lumen and will be used synthesize ATP in a later step. Because the electrons have lost energy prior to their arrival at PSI, they must be re-energized by PSI, hence, another photon is absorbed by the PSI antenna. That energy is relayed to the PSI reaction center (called P700). P700 is oxidized and sends a high-energy electron to NADP+ to form NADPH. Thus, PSII captures the energy to create proton gradients to make ATP, and PSI captures the energy to reduce NADP+ into NADPH. The two photosystems work in concert, in part, to guarantee that the production of NADPH will roughly equal the production of ATP. Other mechanisms exist to fine-tune that ratio to exactly match the chloroplast’s constantly changing energy needs.Generating an Energy Carrier: ATPAs in the intermembrane space of the mitochondria during cellular respiration, the buildup of hydrogen ions inside the thylakoid lumen creates a concentration gradient. The passive diffusion of hydrogen ions from high concentration (in the thylakoid lumen) to low concentration (in the stroma) is harnessed to create ATP, just as in the electron transport chain of cellular respiration. The ions build up energy because of diffusion and because they all have the same electrical charge, repelling each other.To release this energy, hydrogen ions will rush through any opening, similar to water jetting through a hole in a dam. In the thylakoid, that opening is a passage through a specialized protein channel called the ATP synthase. The energy released by the hydrogen ion stream allows ATP synthase to attach a third phosphate group to ADP, which forms a molecule of ATP (). The flow of hydrogen ions through ATP synthase is called chemiosmosis because the ions move from an area of high to an area of low concentration through a semi-permeable structure of the thylakoid.
-Visit this site and click through the animation to view the process of photosynthesis within a leaf.
+Visit this site and click through the animation to view the process of photosynthesis within a leaf.
diff --git a/modules/m66475/index.cnxml b/modules/m66475/index.cnxml
index c090602ee..65ac36be7 100644
--- a/modules/m66475/index.cnxml
+++ b/modules/m66475/index.cnxml
@@ -49,7 +49,7 @@ K., Tag, A., Fletcher, S. and Hawkins, A. Department of Biology, Texas A&M U
Stage 3: RegenerationInterestingly, at this point, only one of the G3P molecules leaves the Calvin cycle and is sent to the cytoplasm to contribute to the formation of other compounds needed by the plant. Because the G3P exported from the chloroplast has three carbon atoms, it takes three “turns” of the Calvin cycle to fix enough net carbon to export one G3P. But each turn makes two G3Ps, thus three turns make six G3Ps. One is exported while the remaining five G3P molecules remain in the cycle and are used to regenerate RuBP, which enables the system to prepare for more CO2 to be fixed. Three more molecules of ATP are used in these regeneration reactions.
-This link leads to an animation of photosynthesis and the Calvin cycle. Photosynthesis
+This link leads to an animation of photosynthesis and the Calvin cycle. PhotosynthesisDuring the evolution of photosynthesis, a major shift occurred from the bacterial type of photosynthesis that involves only one photosystem and is typically anoxygenic (does not generate oxygen) into modern oxygenic (does generate oxygen) photosynthesis, employing two photosystems. This modern oxygenic photosynthesis is used by many organisms—from giant tropical leaves in the rainforest to tiny cyanobacterial cells—and the process and components of this photosynthesis remain largely the same. Photosystems absorb light and use electron transport chains to convert energy into the chemical energy of ATP and NADH. The subsequent light-independent reactions then assemble carbohydrate molecules with this energy.In the harsh dry heat of the desert, plants must conserve and use every drop of water to survive. Because stomata must open to allow for the uptake of CO2, water escapes from the leaf during active photosynthesis. Desert plants have evolved processes to conserve water and deal with harsh conditions. Mechanisms to capture and store CO2 allows plants to adapt to living with less water. Some plants such as cacti () can prepare materials for photosynthesis during the night by a temporary carbon fixation/storage process, because opening the stomata at this time conserves water due to cooler temperatures. During the day cacti use the captured CO2 for photosynthesis, and keep their stomata closed.
diff --git a/modules/m66478/index.cnxml b/modules/m66478/index.cnxml
index 735ae9da8..047c59cf7 100644
--- a/modules/m66478/index.cnxml
+++ b/modules/m66478/index.cnxml
@@ -37,7 +37,7 @@
The Mitotic PhaseThe mitotic phase is a multistep process during which the duplicated chromosomes are aligned, separated, and move into two new, identical daughter cells. The first portion of the mitotic phase is called karyokinesis, or nuclear division. As we have just seen, the second portion of the mitotic phase (and often viewed as a process separate from and following mitosis) is called cytokinesis—the physical separation of the cytoplasmic components into the two daughter cells.
-Revisit the stages of mitosis at this site.
+Revisit the stages of mitosis at this site.Karyokinesis (Mitosis)Karyokinesis, also known as mitosis, is divided into a series of phases—prophase, prometaphase, metaphase, anaphase, and telophase—that result in the division of the cell nucleus ().
diff --git a/modules/m66479/index.cnxml b/modules/m66479/index.cnxml
index 3202a14bc..26e433234 100644
--- a/modules/m66479/index.cnxml
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@@ -38,7 +38,7 @@
The M CheckpointThe M checkpoint occurs near the end of the metaphase stage of karyokinesis. The M checkpoint is also known as the spindle checkpoint, because it determines whether all the sister chromatids are correctly attached to the spindle microtubules. Because the separation of the sister chromatids during anaphase is an irreversible step, the cycle will not proceed until the kinetochores of each pair of sister chromatids are firmly anchored to at least two spindle fibers arising from opposite poles of the cell.
-Watch what occurs at the G1, G2, and M checkpoints by visiting this website to see an animation of the cell cycle.
+Watch what occurs at the G1, G2, and M checkpoints by visiting this website to see an animation of the cell cycle.
diff --git a/modules/m66483/index.cnxml b/modules/m66483/index.cnxml
index fe9589a7c..4f48159a0 100644
--- a/modules/m66483/index.cnxml
+++ b/modules/m66483/index.cnxml
@@ -57,7 +57,7 @@ chromosomes. Credit: Rao, A.and Fletcher, S. Department of Biology, Texas A&
Telophase I and CytokinesisIn telophase, the separated chromosomes arrive at opposite poles. The remainder of the typical telophase events may or may not occur, depending on the species. In some organisms, the chromosomes “decondense” and nuclear envelopes form around the separated sets of chromatids produced during telophase I. In other organisms, cytokinesis—the physical separation of the cytoplasmic components into two daughter cells—occurs without reformation of the nuclei. In nearly all species of animals and some fungi, cytokinesis separates the cell contents via a cleavage furrow (constriction of the actin ring that leads to cytoplasmic division). In plants, a cell plate is formed during cell cytokinesis by Golgi vesicles fusing at the metaphase plate. This cell plate will ultimately lead to the formation of cell walls that separate the two daughter cells.Two haploid cells are the result of the first meiotic division of a diploid cell. The cells are haploid because at each pole, there is just one of each pair of the homologous chromosomes. Therefore, only one full set of the chromosomes is present. This is why the cells are considered haploid—there is only one chromosome set, even though each chromosome still consists of two sister chromatids. Recall that sister chromatids are merely duplicates of one of the two homologous chromosomes (except for changes that occurred during crossing over). In meiosis II, these two sister chromatids will separate, creating four haploid daughter cells.
-Review the process of meiosis, observing how chromosomes align and migrate, at Meiosis: An Interactive Animation.
+Review the process of meiosis, observing how chromosomes align and migrate, at Meiosis: An Interactive Animation.
@@ -106,7 +106,7 @@ metaphase II. In anaphase II, the sister chromatids separate. Telophase II and c
Some characteristics of organisms are so widespread and fundamental that it is sometimes difficult to remember that they evolved like other simple traits. Meiosis is such an extraordinarily complex series of cellular events that biologists have had trouble testing hypotheses concerning how it may have evolved. Although meiosis is inextricably entwined with sexual reproduction and its advantages and disadvantages, it is important to separate the questions of the evolution of meiosis and the evolution of sex, because early meiosis may have been advantageous for different reasons than it is now. Thinking outside the box and imagining what the early benefits from meiosis might have been is one approach to uncovering how it may have evolved.Meiosis and mitosis share obvious cellular processes, and it makes sense that meiosis evolved from mitosis. The difficulty lies in the clear differences between meiosis I and mitosis. Adam Wilkins and Robin HollidayAdam S. Wilkins and Robin Holliday, “The Evolution of Meiosis from Mitosis,” Genetics 181 (2009): 3–12. summarized the unique events that needed to occur for the evolution of meiosis from mitosis. These steps are homologous chromosome pairing and synapsis, crossover exchanges, sister chromatids remaining attached during anaphase, and suppression of DNA replication in interphase. They argue that the first step is the hardest and most important and that understanding how it evolved would make the evolutionary process clearer. They suggest genetic experiments that might shed light on the evolution of synapsis.There are other approaches to understanding the evolution of meiosis in progress. Different forms of meiosis exist in single-celled protists. Some appear to be simpler or more “primitive” forms of meiosis. Comparing the meiotic divisions of different protists may shed light on the evolution of meiosis. Marilee Ramesh and colleaguesMarilee A. Ramesh, Shehre-Banoo Malik and John M. Logsdon, Jr, “A Phylogenetic Inventory of Meiotic Genes: Evidence for Sex in Giardia and an Early Eukaryotic Origin of Meiosis,” Current Biology 15 (2005):185–91. compared the genes involved in meiosis in protists to understand when and where meiosis might have evolved. Although research is still ongoing, recent scholarship into meiosis in protists suggests that some aspects of meiosis may have evolved later than others. This kind of genetic comparison can tell us what aspects of meiosis are the oldest and what cellular processes they may have borrowed from in earlier cells.
-Click through the steps of this interactive animation to compare the meiotic process of cell division to that of mitosis at How Cells Divide.
+Click through the steps of this interactive animation to compare the meiotic process of cell division to that of mitosis at How Cells Divide.Section SummarySexual reproduction requires that organisms produce cells that can fuse during fertilization to produce offspring. In most organisms, fertilization occurs between two haploid cells, the larger being called “female” or “egg” and the smaller being called “male” or “sperm." In most animals, meiosis is used to produce haploid eggs and sperm from diploid parent cells so that the fusion of an egg and sperm produces a diploid zygote. As with mitosis, DNA replication occurs prior to meiosis during the S-phase of the cell cycle so that each chromosome becomes a pair of sister chromatids. In meiosis, there are two rounds of nuclear division resulting in four nuclei and usually four daughter cells, each with half the number of chromosomes as the parent cell. The first division separates homologous chromosomes, and the second—like mitosis—separates chromatids into individual chromosomes. Meiosis generates variation in the daughter nuclei during crossover in prophase I as well as during the random alignment of tetrads at metaphase I. The cells that are produced by meiosis are genetically unique.Meiosis and mitosis share similar processes, but have distinct outcomes. Mitotic divisions are single nuclear divisions that produce genetically identical daughter nuclei (i.e., each daughter nucleus has the same number of chromosome sets as the original cell). In contrast, meiotic divisions include two nuclear divisions that ultimately produce four genetically different daughter nuclei that have only one chromosome set (instead of the two sets of chromosomes in the parent cell). The main differences between the two nuclear division processes take place during the first division of meiosis: homologous chromosomes pair, crossover, and exchange homologous nonsister chromatid segments. The homologous chromosomes separate into different nuclei during meiosis I, causing a reduction of ploidy level in the first division. The second division of meiosis is similar to a mitotic division, except that the daughter cells do not contain identical genomes because of crossover and chromosome recombination in prophase I.
diff --git a/modules/m66486/index.cnxml b/modules/m66486/index.cnxml
index 28299ef50..4be62be72 100644
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@@ -18,7 +18,7 @@
Johann Gregor Mendel is considered the father of genetics.
-Johann Gregor Mendel (1822–1884) () was a lifelong learner, teacher, scientist, and man of faith. As a young adult, he joined the Augustinian Abbey of St. Thomas in Brno in what is now the Czech Republic. Supported by the monastery, he taught physics, botany, and natural science courses at the secondary and university levels. In 1856, he began a decade-long research pursuit involving inheritance patterns in honeybees and plants, ultimately settling on pea plants as his primary model system (a system with convenient characteristics used to study a specific biological phenomenon to be applied to other systems). In 1865, Mendel presented the results of his experiments with nearly 30,000 pea plants to the local Natural History Society. He demonstrated that traits are transmitted from parents to offspring independently of other traits and in dominant and recessive patterns. In 1866, he published his work, Experiments in Plant Hybridization,Johann Gregor Mendel, Versuche über Pflanzenhybriden Verhandlungen des naturforschenden Vereines in Brünn, Bd. IV für das Jahr, 1865 Abhandlungen, 3–47. [for English translation see http://www.mendelweb.org/Mendel.plain.html]
+Johann Gregor Mendel (1822–1884) () was a lifelong learner, teacher, scientist, and man of faith. As a young adult, he joined the Augustinian Abbey of St. Thomas in Brno in what is now the Czech Republic. Supported by the monastery, he taught physics, botany, and natural science courses at the secondary and university levels. In 1856, he began a decade-long research pursuit involving inheritance patterns in honeybees and plants, ultimately settling on pea plants as his primary model system (a system with convenient characteristics used to study a specific biological phenomenon to be applied to other systems). In 1865, Mendel presented the results of his experiments with nearly 30,000 pea plants to the local Natural History Society. He demonstrated that traits are transmitted from parents to offspring independently of other traits and in dominant and recessive patterns. In 1866, he published his work, Experiments in Plant Hybridization,Johann Gregor Mendel, Versuche über Pflanzenhybriden Verhandlungen des naturforschenden Vereines in Brünn, Bd. IV für das Jahr, 1865 Abhandlungen, 3–47. [for English translation see http://www.mendelweb.org/Mendel.plain.html]
in the proceedings of the Natural History Society of Brünn.Mendel’s work went virtually unnoticed by the scientific community, which believed, incorrectly, that the process of inheritance involved a blending of parental traits that produced an intermediate physical appearance in offspring. The blending theory of inheritance asserted that the original parental traits were lost or absorbed by the blending in the offspring, but we now know that this is not the case. This hypothetical process appeared to be correct because of what we know now as continuous variation. Continuous variation results from the action of many genes to determine a characteristic like human height. Offspring appear to be a “blend” of their parents’ traits.Instead of continuous characteristics, Mendel worked with traits that were inherited in distinct classes (specifically, violet versus white flowers); this is referred to as discontinuous variation. Mendel’s choice of these kinds of traits allowed him to see experimentally that the traits were not blended in the offspring, nor were they absorbed, but rather that they kept their distinctness and could be passed on. In 1868, Mendel became abbot of the monastery and exchanged his scientific pursuits for his pastoral duties. He was not recognized for his extraordinary scientific contributions during his lifetime. In fact, it was not until 1900 that his work was rediscovered, reproduced, and revitalized by scientists on the brink of discovering the chromosomal basis of heredity.
diff --git a/modules/m66488/index.cnxml b/modules/m66488/index.cnxml
index c7c2ef06f..d7ba6ac50 100644
--- a/modules/m66488/index.cnxml
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@@ -116,7 +116,7 @@
EpistasisMendel’s studies in pea plants implied that the sum of an individual’s phenotype was controlled by genes (or as he called them, unit factors), such that every characteristic was distinctly and completely controlled by a single gene. In fact, single observable characteristics are almost always under the influence of multiple genes (each with two or more alleles) acting in unison. For example, at least eight genes contribute to eye color in humans.
-Eye color in humans is determined by multiple genes. Use the Eye Color Calculator to predict the eye color of children from parental eye color.
+Eye color in humans is determined by multiple genes. Use the Eye Color Calculator to predict the eye color of children from parental eye color.In some cases, several genes can contribute to aspects of a common phenotype without their gene products ever directly interacting. In the case of organ development, for instance, genes may be expressed sequentially, with each gene adding to the complexity and specificity of the organ. Genes may function in complementary or synergistic fashions, such that two or more genes need to be expressed simultaneously to affect a phenotype. Genes may also oppose each other, with one gene modifying the expression of another.In epistasis, the interaction between genes is antagonistic, such that one gene masks or interferes with the expression of another. “Epistasis” is a word composed of Greek roots that mean “standing upon.” The alleles that are being masked or silenced are said to be hypostatic to the epistatic alleles that are doing the masking. Often the biochemical basis of epistasis is a gene pathway in which the expression of one gene is dependent on the function of a gene that precedes or follows it in the pathway.
diff --git a/modules/m66491/index.cnxml b/modules/m66491/index.cnxml
index 7cc55b6df..2ecfc41a9 100644
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@@ -75,7 +75,7 @@
To construct a chromosome map, Sturtevant assumed that genes were ordered serially on threadlike chromosomes. He also assumed that the incidence of recombination between two homologous chromosomes could occur with equal likelihood anywhere along the chromosome's length. Operating under these assumptions, Sturtevant postulated that alleles that were far apart on a chromosome were more likely to dissociate during meiosis simply because there was a larger region over which recombination could occur. Conversely, alleles that were close to each other on the chromosome were likely to be inherited together. The average number of crossovers between two alleles—that is, their recombination frequency—correlated with their genetic distance from each other, relative to the locations of other genes on that chromosome. Considering the example cross between AaBb and aabb above, we could calculate the recombination's frequency as 50/1000 = 0.05. That is, the likelihood of a crossover between genes A/a and B/b was 0.05, or 5 percent. Such a result would indicate that the genes were definitively linked, but that they were far enough apart for crossovers to occasionally occur. Sturtevant divided his genetic map into map units, or centimorgans (cM), in which a 0.01 recombination frequency corresponds to 1 cM.By representing alleles in a linear map, Sturtevant suggested that genes can range from linking perfectly (recombination frequency = 0) to unlinking perfectly (recombination frequency = 0.5) when genes are on different chromosomes or genes separate very far apart on the same chromosome. Perfectly unlinked genes correspond to the frequencies Mendel predicted to assort independently in a dihybrid cross. A 0.5 recombination frequency indicates that 50 percent of offspring are recombinants and the other 50 percent are parental types. That is, every type of allele combination is represented with equal frequency. This representation allowed Sturtevant to additively calculate distances between several genes on the same chromosome. However, as the genetic distances approached 0.50, his predictions became less accurate because it was not clear whether the genes were very far apart on the same or on different chromosomes.In 1931, Barbara McClintock and Harriet Creighton demonstrated the crossover of homologous chromosomes in corn plants. Weeks later, Curt Stern demonstrated microscopically homologous recombination in Drosophila. Stern observed several X-linked phenotypes that were associated with a structurally unusual and dissimilar X chromosome pair in which one X was missing a small terminal segment, and the other X was fused to a piece of the Y chromosome. By crossing flies, observing their offspring, and then visualizing the offspring’s chromosomes, Stern demonstrated that every time the offspring allele combination deviated from either of the parental combinations, there was a corresponding exchange of an X chromosome segment. Using mutant flies with structurally distinct X chromosomes was the key to observing the products of recombination because DNA sequencing and other molecular tools were not yet available. We now know that homologous chromosomes regularly exchange segments in meiosis by reciprocally breaking and rejoining their DNA at precise locations. Aurora Ruiz-Herrera, for example, studies the occurrence of genetic breakpoints at locations in the chromosomes known as fragile sites. By identifying chromosomal fragile sites that are shared between humans and other primates, Ruiz-Herrera has provided a deeper understanding of mammalian and specifically human evolution.
-Review Sturtevant’s process to create a genetic map on the basis of recombination frequencies here.
+Review Sturtevant’s process to create a genetic map on the basis of recombination frequencies here.
diff --git a/modules/m66494/index.cnxml b/modules/m66494/index.cnxml
index 72c87e5b3..d42c8ef60 100644
--- a/modules/m66494/index.cnxml
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@@ -58,7 +58,7 @@ Biology, Texas A&M University.Whi
The incidence of having a fetus with trisomy 21 increases dramatically with maternal age.
-Visualize adding a chromosome that leads to Down syndrome in this video simulation.
+Visualize adding a chromosome that leads to Down syndrome in this video simulation.
diff --git a/modules/m66497/index.cnxml b/modules/m66497/index.cnxml
index 6b5712e1c..3a808c183 100644
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+++ b/modules/m66497/index.cnxml
@@ -40,7 +40,7 @@
The specification of a single amino acid by multiple similar codons is called "degeneracy." Degeneracy is believed to be a cellular mechanism to reduce the negative impact of random mutations. Codons that specify the same amino acid typically only differ by one nucleotide. In addition, amino acids with chemically similar side chains are encoded by similar codons. For example, aspartate (Asp) and glutamate (Glu), which occupy the GA* block, are both negatively charged. This nuance of the genetic code ensures that a single-nucleotide substitution mutation might specify the same amino acid but have no effect or specify a similar amino acid, preventing the protein from being rendered completely nonfunctional.The genetic code is nearly universal. With a few minor exceptions, virtually all species use the same genetic code for protein synthesis. Conservation of codons means that a purified mRNA encoding the globin protein in horses could be transferred to a tulip cell, and the tulip would synthesize horse globin. That there is only one genetic code is powerful evidence that all of life on Earth shares a common origin, especially considering that there are about 1084 possible combinations of 20 amino acids and 64 triplet codons.
-Transcribe a gene and translate it to protein using complementary pairing and the genetic code at this site.
+Transcribe a gene and translate it to protein using complementary pairing and the genetic code at this site.
The deletion of two nucleotides shifts the reading frame of an mRNA and changes the entire protein message, creating a nonfunctional protein or terminating protein synthesis altogether.
The σ subunit of prokaryotic RNA polymerase recognizes consensus sequences found in the promoter region upstream of the transcription start site. The σ subunit dissociates from the polymerase after transcription has been initiated.
-View this MolecularMovies animation to see the transcription process as it happens in the cell.
+View this MolecularMovies animation to see the transcription process as it happens in the cell.
@@ -46,7 +46,7 @@
Multiple polymerases can transcribe a single bacterial gene while numerous ribosomes concurrently translate the mRNA transcripts into polypeptides. In this way, a specific protein can rapidly reach a high concentration in the bacterial cell.
-Visit this BioStudio animation to see the process of prokaryotic transcription.
+Visit this BioStudio animation to see the process of prokaryotic transcription.Section SummaryIn prokaryotes, mRNA synthesis is initiated at a promoter sequence on the DNA template comprising two consensus sequences that recruit RNA polymerase. The prokaryotic polymerase consists of a core enzyme of four protein subunits and a σ protein that assists only with initiation. Elongation synthesizes mRNA in the 5' to 3' direction at a rate of 40 nucleotides per second. Termination liberates the mRNA and occurs either by rho protein interaction or by the formation of an mRNA hairpin.
diff --git a/modules/m66500/index.cnxml b/modules/m66500/index.cnxml
index 0dfe51d4a..3f51da309 100644
--- a/modules/m66500/index.cnxml
+++ b/modules/m66500/index.cnxml
@@ -50,7 +50,7 @@
Errors in splicing are implicated in cancers and other human diseases. What kinds of mutations might lead to splicing errors? Think of different possible outcomes if splicing errors occur.Note that more than 70 individual introns can be present, and each has to undergo the process of splicing—in addition to 5' capping and the addition of a poly-A tail—just to generate a single, translatable mRNA molecule.
-See how introns are removed during RNA splicing at this website.
+See how introns are removed during RNA splicing at this website.Processing of tRNAs and rRNAs
diff --git a/modules/m66501/index.cnxml b/modules/m66501/index.cnxml
index 9e92d8a9e..7a476bfa1 100644
--- a/modules/m66501/index.cnxml
+++ b/modules/m66501/index.cnxml
@@ -18,7 +18,7 @@
The Protein Synthesis MachineryIn addition to the mRNA template, many molecules and macromolecules contribute to the process of translation. The composition of each component may vary across species; for example, ribosomes may consist of different numbers of rRNAs and polypeptides depending on the organism. However, the general structures and functions of the protein synthesis machinery are comparable from bacteria to human cells. Translation requires the input of an mRNA template, ribosomes, tRNAs, and various enzymatic factors. (Note: A ribosome can be thought of as an enzyme whose amino acid binding sites are specified by mRNA.)
-Click through the steps of this PBS interactive to see protein synthesis in action.
+Click through the steps of this PBS interactive to see protein synthesis in action.RibosomesEven before an mRNA is translated, a cell must invest energy to build each of its ribosomes. In E. coli, there are between 10,000 and 70,000 ribosomes present in each cell at any given time. A ribosome is a complex macromolecule composed of structural and catalytic rRNAs, and many distinct polypeptides. In eukaryotes, the nucleolus is completely specialized for the synthesis and assembly of rRNAs.Ribosomes exist in the cytoplasm of prokaryotes and in the cytoplasm and rough endoplasmic reticulum of eukaryotes. Mitochondria and chloroplasts also have their own ribosomes in the matrix and stroma, which look more similar to prokaryotic ribosomes (and have similar drug sensitivities) than the ribosomes just outside their outer membranes in the cytoplasm. Ribosomes dissociate into large and small subunits when they are not synthesizing proteins and reassociate during the initiation of translation. In E. coli, the small subunit is described as 30S, and the large subunit is 50S, for a total of 70S (recall that Svedberg units are not additive). Mammalian ribosomes have a small 40S subunit and a large 60S subunit, for a total of 80S. The small subunit is responsible for binding the mRNA template, whereas the large subunit sequentially binds tRNAs. Each mRNA molecule is simultaneously translated by many ribosomes, all synthesizing protein in the same direction: reading the mRNA from 5' to 3' and synthesizing the polypeptide from the N terminus to the C terminus. The complete mRNA/poly-ribosome structure is called a polysome.
diff --git a/modules/m66509/index.cnxml b/modules/m66509/index.cnxml
index fba85c533..3f524587e 100644
--- a/modules/m66509/index.cnxml
+++ b/modules/m66509/index.cnxml
@@ -24,7 +24,7 @@
Tumor Suppressor Genes, Oncogenes, and CancerIn normal cells, some genes function to prevent excess, inappropriate cell growth. These are tumor-suppressor genes, which are active in normal cells to prevent uncontrolled cell growth. There are many tumor-suppressor genes in cells. The most studied tumor-suppressor gene is p53, which is mutated in over 50 percent of all cancer types. The p53 protein itself functions as a transcription factor. It can bind to sites in the promoters of genes to initiate transcription. Therefore, the mutation of p53 in cancer will dramatically alter the transcriptional activity of its target genes.
-Watch this animation to learn more about the use of p53 in fighting cancer.
+Watch this animation to learn more about the use of p53 in fighting cancer.Proto-oncogenes are positive cell-cycle regulators. When mutated, proto-oncogenes can become oncogenes and cause cancer. Overexpression of the oncogene can lead to uncontrolled cell growth. This is because oncogenes can alter transcriptional activity, stability, or protein translation of another gene that directly or indirectly controls cell growth. An example of an oncogene involved in cancer is a protein called myc. Myc is a transcription factor that is aberrantly activated in Burkett’s Lymphoma, a cancer of the lymph system. Overexpression of myc transforms normal B cells into cancerous cells that continue to grow uncontrollably. High B-cell numbers can result in tumors that can interfere with normal bodily function. Patients with Burkett’s lymphoma can develop tumors on their jaw or in their mouth that interfere with the ability to eat.
diff --git a/modules/m66511/index.cnxml b/modules/m66511/index.cnxml
index 29f95740c..778aaa02c 100644
--- a/modules/m66511/index.cnxml
+++ b/modules/m66511/index.cnxml
@@ -46,7 +46,7 @@
Scientists use polymerase chain reaction, or PCR, to amplify a specific DNA sequence. Primers—short pieces of DNA complementary to each end of the target sequence combine with genomic DNA, Taq polymerase, and deoxynucleotides. Taq polymerase is a DNA polymerase isolated from the thermostable bacterium Thermus aquaticus that is able to withstand the high temperatures that scientists use in PCR. Thermus aquaticus grows in the Lower Geyser Basin of Yellowstone National Park. Reverse transcriptase PCR (RT-PCR) is similar to PCR, but cDNA is made from an RNA template before PCR begins.
DNA fragments can also be amplified from an RNA template in a process called reverse transcriptase PCR (RT-PCR). The first step is to recreate the original DNA template strand (called cDNA) by applying DNA nucleotides to the mRNA. This process is called reverse transcription. This requires the presence of an enzyme called reverse transcriptase. After the cDNA is made, regular PCR can be used to amplify it.
-Deepen your understanding of the polymerase chain reaction by watching this video.
+Deepen your understanding of the polymerase chain reaction by watching this video.Hybridization, Southern Blotting, and Northern Blotting
@@ -79,7 +79,7 @@
-View an animation of recombination in cloning from the DNA Learning Center.
+View an animation of recombination in cloning from the DNA Learning Center.
diff --git a/modules/m66512/index.cnxml b/modules/m66512/index.cnxml
index c2b7f93a8..d7b14c906 100644
--- a/modules/m66512/index.cnxml
+++ b/modules/m66512/index.cnxml
@@ -48,7 +48,7 @@
The web page displays the comparison of the gene sequences of many organisms to the Human Insulin Receptor gene. Explore the type of information provided, select the groups of organisms needed for testing of the hypothesis from the top portion of the displayed data. Focus the attention to the bottom part, the Selected Orthologues. Explore which columns are relevant to the needed information.On the same page, there are other options to explore, not all are necessary for the task, however it might give more insight to the value of genome/gene comparisons.
-Online Mendelian Inheritance in Man (OMIM) is a searchable online catalog of human genes and genetic disorders. This website shows genome mapping information, and also details the history and research of each trait and disorder. Click this link to search for traits (such as handedness) and genetic disorders (such as diabetes).
+Online Mendelian Inheritance in Man (OMIM) is a searchable online catalog of human genes and genetic disorders. This website shows genome mapping information, and also details the history and research of each trait and disorder. Click this link to search for traits (such as handedness) and genetic disorders (such as diabetes).Section Summary
diff --git a/modules/m66513/index.cnxml b/modules/m66513/index.cnxml
index a159e2d17..51aec57f2 100644
--- a/modules/m66513/index.cnxml
+++ b/modules/m66513/index.cnxml
@@ -42,7 +42,7 @@ compare the inputted sequence against the human genome’s known sequences. The
Use of Whole-Genome Sequences of Model OrganismsBritish biochemist and Nobel Prize winner Fred Sanger used a bacterial virus, the bacteriophage fx174 (5368 base pairs), to completely sequence the first genome. Other scientists later sequenced several other organelle and viral genomes. American biotechnologist, biochemist, geneticist, and businessman Craig Venter sequenced the bacterium Haemophilus influenzae in the 1980s. Approximately 74 different laboratories collaborated on sequencing the genome of the yeast Saccharomyces cerevisiae, which began in 1989 and was completed in 1996, because it was 60 times bigger than any other genome sequencing. By 1997, the genome sequences of two important model organisms were available: the bacterium Escherichia coli K12 and the yeast Saccharomyces cerevisiae. We now know the genomes of other model organisms, such as the mouse Mus musculus, the fruit fly Drosophila melanogaster, the nematode Caenorhabditis. elegans, and humans Homo sapiens. Researchers perform extensive basic research in model organisms because they can apply the information to genetically similar organisms. A model organism is a species that researchers use as a model to understand the biological processes in other species that the model organism represents. Having entire genomes sequenced helps with the research efforts in these model organisms. The process of attaching biological information to gene sequences is genome annotation. Annotating gene sequences helps with basic experiments in molecular biology, such as designing PCR primers and RNA targets.
-Click through each genome sequencing step at this site.
+Click through each genome sequencing step at this site.
diff --git a/modules/m66518/index.cnxml b/modules/m66518/index.cnxml
index 2ee1a24cb..810ee16d8 100644
--- a/modules/m66518/index.cnxml
+++ b/modules/m66518/index.cnxml
@@ -77,7 +77,7 @@
Some structures exist in organisms that have no apparent function at all, and appear to be residual parts from a past common ancestor. We call these unused structures without function vestigial structures. Other examples of vestigial structures are wings on flightless birds, leaves on some cacti, and hind leg bones in whales. Not all similarities represent homologous structures. As explained in Determining Evolutionary Relationships, when similar characteristics occur because of environmental constraints and not due to a close evolutionary relationship, it is an analogy or homoplasy. For example, insects use wings to fly like bats and birds, but the wing structure and embryonic origin are completely different. These are analogous structures (). On the other side, the bird and bat wings are homologous because the bones are inherited from a common ancestor, while the wings themselves are analogous as they evolved independently.
-Watch this video exploring the bones in the human body.
+Watch this video exploring the bones in the human body. Another piece of evidence of evolution is the convergence of form in organisms that share similar environments. For example, species of unrelated animals, such as the arctic fox and ptarmigan, living in the arctic region have been selected for seasonal white phenotypes during winter to blend with the snow and ice (). These similarities occur not because of common ancestry, but because of similar selection pressures—the benefits of predators not seeing them.
@@ -100,7 +100,7 @@
Misconceptions of EvolutionAlthough the theory of evolution generated some controversy when Darwin first proposed it, biologists almost universally accepted it, particularly younger biologists, within 20 years after publication of On theOrigin of Species. Nevertheless, the theory of evolution is a difficult concept and misconceptions about how it works abound.
-This site addresses some of the main misconceptions associated with the theory of evolution.
+This site addresses some of the main misconceptions associated with the theory of evolution. Evolution Is Just a TheoryCritics of the theory of evolution dismiss its importance by purposefully confounding the everyday usage of the word “theory” with the way scientists use the word. In science, we understand a “theory” to be a body of thoroughly tested and verified explanations for a set of observations of the natural world. Scientists have a theory of the atom, a theory of gravity, and the theory of relativity, each which describes understood facts about the world. In the same way, the theory of evolution describes facts about the living world. As such, a theory in science has survived significant efforts to discredit it by scientists. In contrast, a “theory” in common vernacular is a word meaning a guess or suggested explanation. This meaning is more akin to the scientific concept of “hypothesis.” When critics of evolution say it is “just a theory,” they are implying that there is little evidence supporting it and that it is still in the process of rigorous testing. This is a mischaracterization.
diff --git a/modules/m66520/index.cnxml b/modules/m66520/index.cnxml
index ded70db99..958d622e4 100644
--- a/modules/m66520/index.cnxml
+++ b/modules/m66520/index.cnxml
@@ -64,7 +64,7 @@
The honeycreeper birds illustrate adaptive radiation. From one original species of bird, multiple others evolved, each with its own distinctive characteristics.
Notice the differences in the species’ beaks in . Evolution in response to natural selection based on specific food sources in each new habitat led to evolution of a different beak suited to the specific food source. The seed-eating bird has a thicker, stronger beak which is suited to break hard nuts. The nectar-eating birds have long beaks to dip into flowers to reach the nectar. The insect-eating birds have beaks like swords, appropriate for stabbing and impaling insects. Darwin’s finches are another example of adaptive radiation in an archipelago.
-Watch this video to see how scientists use evidence to understand how birds evolved.
+Watch this video to see how scientists use evidence to understand how birds evolved.Sympatric Speciation
diff --git a/modules/m66521/index.cnxml b/modules/m66521/index.cnxml
index 21ff17629..1f10895f9 100644
--- a/modules/m66521/index.cnxml
+++ b/modules/m66521/index.cnxml
@@ -47,7 +47,7 @@
The primary influencing factor on changes in speciation rate is environmental conditions. Under some conditions, selection occurs quickly or radically. Consider a species of snails that had been living with the same basic form for many thousands of years. Layers of their fossils would appear similar for a long time. When a change in the environment takes place—such as a drop in the water level—a small number of organisms are separated from the rest in a brief period of time, essentially forming one large and one tiny population. The tiny population faces new environmental conditions. Because its gene pool quickly became so small, any variation that surfaces and that aids in surviving the new conditions becomes the predominant form.
-Visit this website to continue the speciation story of the snails.
+Visit this website to continue the speciation story of the snails.Section SummarySpeciation is not a precise division: overlap between closely related species can occur in areas called hybrid zones. Organisms reproduce with other similar organisms. The fitness of these hybrid offspring can affect the two species' evolutionary path. Scientists propose two models for the rate of speciation: one model illustrates how a species can change slowly over time. The other model demonstrates how change can occur quickly from a parent generation to a new species. Both models continue to follow natural selection patterns.
diff --git a/modules/m66523/index.cnxml b/modules/m66523/index.cnxml
index 05de0430f..4f739b8b0 100644
--- a/modules/m66523/index.cnxml
+++ b/modules/m66523/index.cnxml
@@ -37,7 +37,7 @@
In theory, if a population is at equilibrium—that is, there are no evolutionary forces acting upon it—generation after generation would have the same gene pool and genetic structure, and these equations would all hold true all of the time. Of course, even Hardy and Weinberg recognized that no natural population is immune to evolution. Populations in nature are constantly changing in genetic makeup due to drift, mutation, possibly migration, and selection. As a result, the only way to determine the exact distribution of phenotypes in a population is to go out and count them. However, the Hardy-Weinberg principle gives scientists a mathematical baseline of a non-evolving population to which they can compare evolving populations and thereby infer what evolutionary forces might be at play. If the frequencies of alleles or genotypes deviate from the value expected from the Hardy-Weinberg equation, then the population is evolving.
-Use this online calculator to determine a population's genetic structure.
+Use this online calculator to determine a population's genetic structure.Section SummaryThe modern synthesis of evolutionary theory grew out of the cohesion of Darwin’s, Wallace’s, and Mendel’s thoughts on evolution and heredity, along with the more modern study of population genetics. It describes the evolution of populations and species, from small-scale changes among individuals to large-scale changes over paleontological time periods. To understand how organisms evolve, scientists can track populations’ allele frequencies over time. If they differ from generation to generation, scientists can conclude that the population is not in Hardy-Weinberg equilibrium, and is thus evolving.
diff --git a/modules/m66524/index.cnxml b/modules/m66524/index.cnxml
index 60f2c16c8..4d43914c9 100644
--- a/modules/m66524/index.cnxml
+++ b/modules/m66524/index.cnxml
@@ -22,7 +22,7 @@
Genetic variabilityNatural selection and some of the other evolutionary forces can only act on heritable traits, namely an organism’s genetic code. Because alleles are passed from parent to offspring, those that confer beneficial traits or behaviors may be selected, while deleterious alleles may not. Acquired traits, for the most part, are not heritable. For example, if an athlete works out in the gym every day, building up muscle strength, the athlete’s offspring will not necessarily grow up to be a body builder. If there is a genetic basis for the ability to run fast, on the other hand, a parent may pass this to a child.
-Before Darwinian evolution became the prevailing theory of the field, French naturalist Jean-Baptiste Lamarck theorized that organisms could inherit acquired traits. While the majority of scientists have not supported this hypothesis, some have recently begun to realize that Lamarck was not completely wrong. Visit this site to learn more.
+Before Darwinian evolution became the prevailing theory of the field, French naturalist Jean-Baptiste Lamarck theorized that organisms could inherit acquired traits. While the majority of scientists have not supported this hypothesis, some have recently begun to realize that Lamarck was not completely wrong. Visit this site to learn more.Heritability is the fraction of phenotype variation that we can attribute to genetic differences, or genetic variability, among individuals in a population. The greater the heritability of a population’s phenotypic variation, the more susceptible it is to the evolutionary forces that act on heritable variation.We call the diversity of alleles and genotypes within a population genetic variability. When scientists are involved in the breeding of a species, such as with animals in zoos and nature preserves, they try to increase a population’s genetic variability to preserve as much of the phenotypic diversity as possible. This also helps reduce associated risks of inbreeding, the mating of closely related individuals, which can have the undesirable effect of bringing together deleterious recessive mutations that can cause abnormalities and susceptibility to disease. For example, a disease that is caused by a rare, recessive allele might exist in a population, but it will only manifest itself when an individual carries two copies of the allele. Because the allele is rare in a normal, healthy population with unrestricted habitat, the chance that two carriers will mate is low, and even then, only 25 percent of their offspring will inherit the disease allele from both parents. While it is likely to happen at some point, it will not happen frequently enough for natural selection to be able to swiftly eliminate the allele from the population, and as a result, the allele maintains itself at low levels in the gene pool. However, if a family of carriers begins to interbreed with each other, this will dramatically increase the likelihood of two carriers mating and eventually producing diseased offspring, a phenomenon that scientists call inbreeding depression.
@@ -43,7 +43,7 @@
Small populations are more susceptible to the forces of genetic drift. Large populations, alternatively, are buffered against the effects of chance. If one individual of a population of 10 individuals happens to die at a young age before it leaves any offspring to the next generation, all of its genes—1/10 of the population’s gene pool—will be suddenly lost. In a population of 100, that’s only 1 percent of the overall gene pool; therefore, it is much less impactful on the population’s genetic structure.
-Go to this site to watch an animation of random sampling and genetic drift in action.
+Go to this site to watch an animation of random sampling and genetic drift in action.Natural events, such as an earthquake disaster that kills—at random—a large portion of the population, can magnify genetic drift. Known as the bottleneck effect, it results in suddenly wiping out a large portion of the gene pool (). At once, the survivors' genetic structure becomes the entire population's genetic structure, which may be very different from the pre-disaster population.
diff --git a/modules/m66530/index.cnxml b/modules/m66530/index.cnxml
index d12d7d32a..c9ea43679 100644
--- a/modules/m66530/index.cnxml
+++ b/modules/m66530/index.cnxml
@@ -44,7 +44,7 @@
Another aspect of phylogenetic trees is that, unless otherwise indicated, the branches do not account for length of time, only the evolutionary order. In other words, a branch's length does not typically mean more time passed, nor does a short branch mean less time passed— unless specified on the diagram. For example, in , the tree does not indicate how much time passed between the evolution of amniotic eggs and hair. What the tree does show is the order in which things took place. Again using , the tree shows that the oldest trait is the vertebral column, followed by hinged jaws, and so forth. Remember that any phylogenetic tree is a part of the greater whole, and like a real tree, it does not grow in only one direction after a new branch develops. Thus, for the organisms in , just because a vertebral column evolved does not mean that invertebrate evolution ceased. It only means that a new branch formed. Also, groups that are not closely related, but evolve under similar conditions, may appear more phenotypically similar to each other than to a close relative.
-Head to this website to see interactive exercises that allow you to explore the evolutionary relationships among species.
+Head to this website to see interactive exercises that allow you to explore the evolutionary relationships among species.
@@ -66,7 +66,7 @@
-Visit this website to explore the classifications of thousands of organisms. This reference site contains about 10% of the described species on the planet.
+Visit this website to explore the classifications of thousands of organisms. This reference site contains about 10% of the described species on the planet. Recent genetic analysis and other advancements have found that some earlier phylogenetic classifications do not align with the evolutionary past; therefore, researchers must make changes and updates as new discoveries occur. Recall that phylogenetic trees are hypotheses and are modified as data becomes available. In addition, classification historically has focused on grouping organisms mainly by shared characteristics and does not necessarily illustrate how the various groups relate to each other from an evolutionary perspective. For example, despite the fact that a hippopotamus resembles a pig more than a whale, the hippopotamus may be the whale's closest living relative.
diff --git a/modules/m66531/index.cnxml b/modules/m66531/index.cnxml
index 618ef2b29..752ed8278 100644
--- a/modules/m66531/index.cnxml
+++ b/modules/m66531/index.cnxml
@@ -32,7 +32,7 @@
The (c) wing of a honeybee is similar in shape to a (b) bird wing and (a) bat wing, and it serves the same function. However, the honeybee wing is not composed of bones and has a distinctly different structure and embryonic origin. These wing types (insect versus bat and bird) illustrate an analogy—similar structures that do not share an evolutionary history. (credit a: modification of work by U.S. DOI BLM; credit b: modification of work by Steve Hillebrand, USFWS; credit c: modification of work by Jon Sullivan)
-This website has several examples to show how appearances can be misleading in understanding organisms' phylogenetic relationships.
+This website has several examples to show how appearances can be misleading in understanding organisms' phylogenetic relationships.
@@ -88,7 +88,7 @@
To aid in the tremendous task of describing phylogenies accurately, scientists often use the concept of maximum parsimony, which means that events occurred in the simplest, most obvious way. For example, if a group of people entered a forest preserve to hike, based on the principle of maximum parsimony, one could predict that most would hike on established trails rather than forge new ones.For scientists deciphering evolutionary pathways, the same idea is used: the pathway of evolution probably includes the fewest major events that coincide with the evidence at hand. Starting with all of the homologous traits in a group of organisms, scientists look for the most obvious and simple order of evolutionary events that led to the occurrence of those traits.
-Head to this website to learn how researchers use maximum parsimony to create phylogenetic trees.
+Head to this website to learn how researchers use maximum parsimony to create phylogenetic trees.These tools and concepts are only a few strategies scientists use to tackle the task of revealing the evolutionary history of life on Earth. Recently, newer technologies have uncovered surprising discoveries with unexpected relationships, such as the fact that people seem to be more closely related to fungi than fungi are to plants. Sound unbelievable? As the information about DNA sequences grows, scientists will become closer to mapping the evolutionary history of all life on Earth.
diff --git a/modules/m66535/index.cnxml b/modules/m66535/index.cnxml
index ec02ff7bd..dd76f9602 100644
--- a/modules/m66535/index.cnxml
+++ b/modules/m66535/index.cnxml
@@ -25,7 +25,7 @@
AttachmentA virus attaches to a specific receptor site on the host cell membrane through attachment proteins in the capsid or via glycoproteins embedded in the viral envelope. The specificity of this interaction determines the host—and the cells within the host—that can be infected by a particular virus. This can be illustrated by thinking of several keys and several locks, where each key will fit only one specific lock.
-This video explains how influenza attacks the body.
+This video explains how influenza attacks the body.Entry
@@ -136,7 +136,7 @@
HPV, or human papillomavirus, has a naked icosahedral capsid visible in this transmission electron micrograph and a double-stranded DNA genome that is incorporated into the host DNA. The virus, which is sexually transmitted, is oncogenic and can lead to cervical cancer. (credit: modification of work by NCI, NIH; scale-bar data from Matt Russell)
-This video shows the life cycle of a virus.
+This video shows the life cycle of a virus.Section Summary
diff --git a/modules/m66537/index.cnxml b/modules/m66537/index.cnxml
index cfe50f291..7548dfd34 100644
--- a/modules/m66537/index.cnxml
+++ b/modules/m66537/index.cnxml
@@ -26,7 +26,7 @@
Vaccinations are designed to boost immunity to a virus to prevent infection. (credit: Navy Medicine)
-Watch this NOVA video to learn how microbiologists are attempting to replicate the deadly 1918 Spanish influenza virus so they can understand more about virology.
+Watch this NOVA video to learn how microbiologists are attempting to replicate the deadly 1918 Spanish influenza virus so they can understand more about virology. Vaccines and Antiviral Drugs for Treatment
diff --git a/modules/m66540/index.cnxml b/modules/m66540/index.cnxml
index 3e8d1d91f..12902c967 100644
--- a/modules/m66540/index.cnxml
+++ b/modules/m66540/index.cnxml
@@ -36,7 +36,7 @@ Virology is the study of viruses, and a virologist is an individual trained in t
-
This virologist is engaged in fieldwork, sampling eggs from this nest for avian influenza. (credit: Don Becker, USGS EROS, U.S. Fish and Wildlife Service)
If you think you may be interested in a career in virology, find a mentor in the field. Many large medical centers have departments of virology, and smaller hospitals usually have virology labs within their microbiology departments. Volunteer in a virology lab for a semester or work in one over the summer. Discussing the profession and getting a first-hand look at the work will help you decide whether a career in virology is right for you. The American Society of Virology’s website is a good resource for information regarding training and careers in virology.
+
This virologist is engaged in fieldwork, sampling eggs from this nest for avian influenza. (credit: Don Becker, USGS EROS, U.S. Fish and Wildlife Service)
If you think you may be interested in a career in virology, find a mentor in the field. Many large medical centers have departments of virology, and smaller hospitals usually have virology labs within their microbiology departments. Volunteer in a virology lab for a semester or work in one over the summer. Discussing the profession and getting a first-hand look at the work will help you decide whether a career in virology is right for you. The American Society of Virology’s website is a good resource for information regarding training and careers in virology.Section SummaryPrions are infectious agents that consist of protein, but no DNA or RNA, and seem to produce their deadly effects by duplicating their shapes and accumulating in tissues. They are thought to contribute to several progressive brain disorders, including mad cow disease and Creutzfeldt-Jakob disease. Viroids are single-stranded RNA pathogens that infect plants. Their presence can have a severe impact on the agriculture industry.
diff --git a/modules/m66548/index.cnxml b/modules/m66548/index.cnxml
index 99333aa1d..56a61b186 100644
--- a/modules/m66548/index.cnxml
+++ b/modules/m66548/index.cnxml
@@ -35,7 +35,7 @@
The Black Death. The (a) Great Plague of London killed an estimated 200,000 people, or about 20 percent of the city’s population. The causative agent, the (b) bacterium Yersinia pestis, is a Gram-negative, rod-shaped bacterium from the class Gammaproteobacteria. The disease is transmitted through the bite of an infected flea, which is carried on a rodent. Symptoms include swollen lymph nodes, fever, seizure, vomiting of blood, and (c) gangrene. (credit b: Rocky Mountain Laboratories, NIAID, NIH; scale-bar data from Matt Russell; credit c: Textbook of Military Medicine, Washington, D.C., U.S. Dept. of the Army, Office of the Surgeon General, Borden Institute)
-Watch a video on the modern understanding of the Black Death—bubonic plague in Europe during the 14th century.
+Watch a video on the modern understanding of the Black Death—bubonic plague in Europe during the 14th century.Migration of Diseases to New Populations
@@ -71,7 +71,7 @@
The word antibiotic comes from the Greek anti meaning “against” and bios meaning “life.” An antibiotic is a chemical, produced either by microbes or synthetically, that is hostile to or prevents the growth of other organisms. Today’s media often address concerns about an antibiotic crisis. Are the antibiotics that easily treated bacterial infections in the past becoming obsolete? Are there new “superbugs”—bacteria that have evolved to become more resistant to our arsenal of antibiotics? Is this the beginning of the end of antibiotics? All these questions challenge the healthcare community.One of the main causes of antibiotic resistance in bacteria is overexposure to antibiotics. The imprudent and excessive use of antibiotics has resulted in the natural selection of resistant forms of bacteria. The antibiotic kills most of the infecting bacteria, and therefore only the resistant forms remain. These resistant forms reproduce, resulting in an increase in the proportion of resistant forms over non-resistant ones. In addition to transmission of resistance genes to progeny, lateral transfer of resistance genes on plasmids can rapidly spread these genes through a bacterial population. A major misuse of antibiotics is in patients with viral infections like colds or the flu, against which antibiotics are useless. Another problem is the excessive use of antibiotics in livestock. The routine use of antibiotics in animal feed promotes bacterial resistance as well. In the United States, 70 percent of the antibiotics produced are fed to animals. These antibiotics are given to livestock in low doses, which maximize the probability of resistance developing, and these resistant bacteria are readily transferred to humans.
-Watch a recent news report on the problem of routine antibiotic administration to livestock and antibiotic-resistant bacteria.
+Watch a recent news report on the problem of routine antibiotic administration to livestock and antibiotic-resistant bacteria.One of the Superbugs: MRSAThe imprudent use of antibiotics has paved the way for the expansion of resistant bacterial populations. For example, Staphylococcus aureus, often called “staph,” is a common bacterium that can live in the human body and is usually easily treated with antibiotics. However, a very dangerous strain, methicillin-resistant Staphylococcus aureus (MRSA) has made the news over the past few years (). This strain is resistant to many commonly used antibiotics, including methicillin, amoxicillin, penicillin, and oxacillin. MRSA can cause infections of the skin, but it can also infect the bloodstream, lungs, urinary tract, or sites of injury. While MRSA infections are common among people in healthcare facilities, they have also appeared in healthy people who haven’t been hospitalized, but who live or work in tight populations (like military personnel and prisoners). Researchers have expressed concern about the way this latter source of MRSA targets a much younger population than those residing in care facilities. The Journal of the American Medical Association reported that, among MRSA-afflicted persons in healthcare facilities, the average age is 68, whereas people with “community-associated MRSA” (CA-MRSA) have an average age of 23.Naimi, TS, LeDell, KH, Como-Sabetti, K, et al. Comparison of community- and health care-associated methicillin-resistant Staphylococcus aureus infection. JAMA 290 (2003): 2976–84, doi: 10.1001/jama.290.22.2976.
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Early Biotechnology: Cheese, Bread, Wine, Beer, and Yogurt
-According to the United Nations Convention on Biological Diversity, biotechnology is “any technological application that uses biological systems, living organisms, or derivatives thereof, to make or modify products or processes for specific use."http://www.cbd.int/convention/articles/?a=cbd-02, United Nations Convention on Biological Diversity: Article 2: Use of Terms. The concept of “specific use” involves some sort of commercial application. Genetic engineering, artificial selection, antibiotic production, and cell culture are current topics of study in biotechnology and will be described in later chapters. However, humans were using prokaryotes before the term biotechnology was even coined. Some of the products of this early biotechnology are as familiar as cheese, bread, wine, beer, and yogurt, which employ both bacteria and other microbes, such as yeast, a fungus ().
+According to the United Nations Convention on Biological Diversity, biotechnology is “any technological application that uses biological systems, living organisms, or derivatives thereof, to make or modify products or processes for specific use."http://www.cbd.int/convention/articles/?a=cbd-02, United Nations Convention on Biological Diversity: Article 2: Use of Terms. The concept of “specific use” involves some sort of commercial application. Genetic engineering, artificial selection, antibiotic production, and cell culture are current topics of study in biotechnology and will be described in later chapters. However, humans were using prokaryotes before the term biotechnology was even coined. Some of the products of this early biotechnology are as familiar as cheese, bread, wine, beer, and yogurt, which employ both bacteria and other microbes, such as yeast, a fungus ().
Some foods produced by microorganisms. Some of the products derived from the use of prokaryotes in early biotechnology include (a) cheese, (b) wine, (c) beer and bread, and (d) yogurt. (credit bread: modification of work by F. Rodrigo/Wikimedia Commons; credit wine: modification of work by Jon Sullivan; credit beer and bread: modification of work by Kris Miller; credit yogurt: modification of work by Jon Sullivan)
Cheese production began around 4,000 to 7,000 years ago when humans began to breed animals and process their milk. Fermentation in this case preserves nutrients: Milk will spoil relatively quickly, but when processed as cheese, it is more stable. As for beer, the oldest records of brewing are about 6,000 years old and were an integral part of the Sumerian culture. Evidence indicates that the Sumerians discovered fermentation by chance. Wine has been produced for about 4,500 years, and evidence suggests that cultured milk products, like yogurt, have existed for at least 4,000 years.
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-
Glaucocystis. (credit: By ja:User:NEON / commons:User:NEON_ja - Own work, CC BY-SA 2.5, https://commons.wikimedia.org/w/index.php?curid=1706641)
+
Glaucocystis. (credit: By ja:User:NEON / commons:User:NEON_ja - Own work, CC BY-SA 2.5, https://commons.wikimedia.org/w/index.php?curid=1706641)
Red AlgaeRed algae, or rhodophytes lack flagella, and are primarily multicellular, although they range in size from microscopic, unicellular protists to large, multicellular forms grouped into the informal seaweed category. Red algae have a second cell wall outside an inner cellulose cell wall. Carbohydrates in this wall are the source of agarose used for electrophoresis gels and agar for solidifying bacterial media. The "red" in the red algae comes from phycoerythrins, accessory photopigments that are red in color and obscure the green tint of chlorophyll in some species. Other protists classified as red algae lack phycoerythrins and are parasites. Both the red algae and the glaucophytes store carbohydrates in the cytoplasm rather than in the plastid. Red algae are common in tropical waters where they have been detected at depths of 260 meters. Other red algae exist in terrestrial or freshwater environments. The red algae life cycle is an unusual alternation of generations that includes two sporophyte phases, with meiosis occurring only in the second sporophyte.
@@ -76,7 +76,7 @@
-
Cellular Slime Mold. The image shows several stages in the life cycle of Dictyostelium discoideum, including aggregated cells, mobile slugs and their transformation into fruiting bodies with a cluster of spores supported by a stalk. (credit: By Usman Bashir (Own work) [CC BY-SA 4.0 (http://creativecommons.org/licenses/by-sa/4.0)], via Wikimedia Commons)
+
Cellular Slime Mold. The image shows several stages in the life cycle of Dictyostelium discoideum, including aggregated cells, mobile slugs and their transformation into fruiting bodies with a cluster of spores supported by a stalk. (credit: By Usman Bashir (Own work) [CC BY-SA 4.0 (http://creativecommons.org/licenses/by-sa/4.0)], via Wikimedia Commons)
View this video to see the formation of a fruiting body by a cellular slime mold.
@@ -90,7 +90,7 @@
-
A Colonial Choanoflagellate. (credit: By Dhzanette (http://en.wikipedia.org/wiki/Choanoflagellate) [Public domain], via Wikimedia Commons)
The previous supergroups are all the products of primary endosymbiontic events and their organelles—nucleus, mitochondria, and chloroplasts—are what would be considered "typical," i.e., matching the diagrams you would find in an introductory biology book. The next three supergroups all contain at least some photosynthetic members whose chloroplasts were derived by secondary endosymbiosis. They also show some interesting variations in nuclear structure, and modification of mitochondria or chloroplasts.
+
A Colonial Choanoflagellate. (credit: By Dhzanette (http://en.wikipedia.org/wiki/Choanoflagellate) [Public domain], via Wikimedia Commons)
The previous supergroups are all the products of primary endosymbiontic events and their organelles—nucleus, mitochondria, and chloroplasts—are what would be considered "typical," i.e., matching the diagrams you would find in an introductory biology book. The next three supergroups all contain at least some photosynthetic members whose chloroplasts were derived by secondary endosymbiosis. They also show some interesting variations in nuclear structure, and modification of mitochondria or chloroplasts.Rhizaria
@@ -120,7 +120,7 @@
-
A Chlorarachniophyte. This rhizarian is mixotrophic, and can obtain nutrients both by photosynthesis and by trapping various microorganisms with its network of pseudopodia. (credit: By ja:User:NEON / commons:User:NEON_ja (Own work) [CC BY-SA 2.5 (http://creativecommons.org/licenses/by-sa/2.5) or CC BY-SA 2.5 (http://creativecommons.org/licenses/by-sa/2.5)], via Wikimedia Commons)
+
A Chlorarachniophyte. This rhizarian is mixotrophic, and can obtain nutrients both by photosynthesis and by trapping various microorganisms with its network of pseudopodia. (credit: By ja:User:NEON / commons:User:NEON_ja (Own work) [CC BY-SA 2.5 (http://creativecommons.org/licenses/by-sa/2.5) or CC BY-SA 2.5 (http://creativecommons.org/licenses/by-sa/2.5)], via Wikimedia Commons)
Malaria parasite. Red blood cells are shown to be infected with P. falciparum, the causative agent of malaria. In this light microscopic image taken using a 100× oil immersion lens, the ring-shaped P. falciparum stains purple. (credit: modification of work by Michael Zahniser; scale-bar data from Matt Russell)
-This movie depicts the pathogenesis of Plasmodium falciparum, the causative agent of malaria.
+This movie depicts the pathogenesis of Plasmodium falciparum, the causative agent of malaria.TrypanosomesTrypanosoma brucei (), transmitted by tsetse flies (Glossina spp) in Africa, and related flies in South America, is a flagellated endoparasite responsible for the deadly disease nagana in cattle and horses, and for African sleeping sickness in humans. This trypanosome confounds the human immune system by changing its thick layer of surface glycoproteins with each infectious cycle. (The glycoproteins are identified by the immune system as foreign antigens, and a specific antibody defense is mounted against the parasite.) However, T. brucei has thousands of possible antigens, and with each subsequent generation, the protist switches to a glycoprotein coating with a different molecular structure. In this way, T. brucei is capable of replicating continuously without the immune system ever succeeding in clearing the parasite. Without treatment, T. brucei attacks red blood cells, causing the patient to lapse into a coma and eventually die. During epidemic periods, mortality from the disease can be high. Greater surveillance and control measures lead to a reduction in reported cases; some of the lowest numbers reported in 50 years (fewer than 10,000 cases in all of sub-Saharan Africa) have happened since 2009.
-This movie discusses the pathogenesis of Trypanosoma brucei, the causative agent of African sleeping sickness.
+This movie discusses the pathogenesis of Trypanosoma brucei, the causative agent of African sleeping sickness.In Latin America, another species of trypanosome, T. cruzi, is responsible for Chagas disease. T. cruzi infections are mainly caused by a blood-sucking “kissing bug” in the genus Triatoma. These “true bugs” bite the host during the night and then defecate on the wound, transmitting the trypanosome to the victim. The victim scratches the wound, further inoculating the site with trypanosomes at the location of the bite. After about 10 weeks, individuals enter the chronic phase but most never develop further symptoms. In about 30 percent of cases, however, the trypanosome causes further damage, especially to the heart and digestive system tissues in the chronic phase of infection, leading to malnutrition and heart failure due to abnormal heart rhythms. An estimated 10 million people are infected with Chagas disease, and it is estimated to cause 10,000-12,000 deaths per year.
diff --git a/modules/m66558/index.cnxml b/modules/m66558/index.cnxml
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Sexual reproduction introduces genetic variation into a population of fungi. In fungi, sexual reproduction often occurs in response to adverse environmental conditions. During sexual reproduction, two mating types are produced. When both mating types are present in the same mycelium, it is called homothallic, or self-fertile. Heterothallic mycelia require two different, but compatible, mycelia to reproduce sexually.Although there are many variations in fungal sexual reproduction, all include the following three stages (). First, during plasmogamy (literally, “marriage or union of cytoplasm”), two haploid cells fuse, leading to a dikaryotic stage where two haploid nuclei coexist in a single cell. During karyogamy (“nuclear marriage”), the haploid nuclei fuse to form a diploid zygote nucleus. Finally, meiosis takes place in the gametangia (singular, gametangium) organs, in which gametes of different mating types are generated. At this stage, spores are disseminated into the environment.
-Review the characteristics of fungi by watching this video.
+Review the characteristics of fungi by watching this video.Section Summary
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LichensLichens display a range of colors and textures () and can survive in the most unusual and hostile habitats. They cover rocks, gravestones, tree bark, and the ground in the tundra where plant roots cannot penetrate. Lichens can survive extended periods of drought, when they become completely desiccated, and then rapidly become active once water is available again.
-Explore the world of lichens using this site from Oregon State University.
+Explore the world of lichens using this site from Oregon State University.
@@ -74,7 +74,7 @@
The thallus of lichens grows very slowly, expanding its diameter a few millimeters per year. Both the fungus and the alga participate in the formation of dispersal units, called soredia—clusters of algal cells surrounded by mycelia. Soredia are dispersed by wind and water and form new lichens.Lichens are extremely sensitive to air pollution, especially to abnormal levels of nitrogenous and sulfurous compounds. The U.S. Forest Service and National Park Service can monitor air quality by measuring the relative abundance and health of the lichen population in an area. Lichens fulfill many ecological roles. Caribou and reindeer eat lichens, and they provide cover for small invertebrates that hide in the mycelium. In the production of textiles, weavers used lichens to dye wool for many centuries until the advent of synthetic dyes. The pigments used in litmus paper are also extracted from lichens.
-Lichens are used to monitor the quality of air. Read more on this site from the United States Forest Service.
+Lichens are used to monitor the quality of air. Read more on this site from the United States Forest Service.Fungus/Animal MutualismFungi have evolved mutualisms with numerous insects in Phylum Arthropoda: joint-legged invertebrates with a chitinous exoskeleton. Arthropods depend on the fungus for protection from predators and pathogens, while the fungus obtains nutrients and a way to disseminate spores into new environments. The association between species of Basidiomycota and scale insects is one example. The fungal mycelium covers and protects the insect colonies. The scale insects foster a flow of nutrients from the parasitized plant to the fungus.
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Scientists who solely track evolutionary straight lines (that is, monophyly), consider only the Charophytes as plants. The common ancestor of Charophytes and land plants excludes the other members of the Archaeplastida. Charophytes also share other features with the land plants. These will be discussed in more detail in another section.
-Go to this article to get a more in-depth view of the Charophytes.
+Go to this article to get a more in-depth view of the Charophytes.Plant Adaptations to Life on LandAs organisms adapted to life on land, they had to contend with several challenges in the terrestrial environment. Water has been described as “the stuff of life.” The cell’s interior is a thick soup: in this medium, most small molecules dissolve and diffuse, and the majority of the chemical reactions of metabolism take place. Desiccation, or drying out, is a constant danger for an organism exposed to air. Even when parts of a plant are close to a source of water, the aerial structures are likely to dry out. Water also provides buoyancy to organisms. On land, plants need to develop structural support in a medium that does not give the same lift as water. The organism is also subject to bombardment by mutagenic radiation, because air does not filter out ultraviolet rays of sunlight. Additionally, the male gametes must reach the female gametes using new strategies, because swimming is no longer possible. Therefore, both gametes and zygotes must be protected from desiccation. The successful land plants developed strategies to deal with all of these challenges. Not all adaptations appeared at once. Some species never moved very far from the aquatic environment, whereas others went on to conquer the driest environments on Earth.To balance these survival challenges, life on land offers several advantages. First, sunlight is abundant. Water acts as a filter, altering the spectral quality of light absorbed by the photosynthetic pigment chlorophyll. Second, carbon dioxide is more readily available in air than in water, since it diffuses faster in air. Third, land plants evolved before land animals; therefore, until dry land was colonized by animals, no predators threatened plant life. This situation changed as animals emerged from the water and fed on the abundant sources of nutrients in the established flora. In turn, plants developed strategies to deter predation: from spines and thorns to toxic chemicals.
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-To see an animation of the life cycle of a fern and to test your knowledge, go to the website.
+To see an animation of the life cycle of a fern and to test your knowledge, go to the website.Landscape DesignerLooking at the ornamental arrangement of flower beds and fountains typical of the grounds of royal castles and historic houses of Europe, it’s clear that the gardens’ creators knew about more than art and design. They were also familiar with the biology of the plants they chose. Landscape design also has strong roots in the United States’ tradition. A prime example of early American classical design is Monticello, Thomas Jefferson’s private estate. Among his many interests, Jefferson maintained a strong passion for botany. Landscape layout can encompass a small private space like a backyard garden, public gathering places such as Central Park in New York City, or an entire city plan like Pierre L’Enfant’s design for Washington, DC.
@@ -116,7 +116,7 @@
Sphagnum moss. Sphagnum acutifolium is dried peat moss and can be used as fuel. (credit: Ken Goulding)
The attractive fronds of ferns make them a favorite ornamental plant. Because they thrive in low light, they are well suited as house plants. More importantly, fiddleheads of bracken fern (Pteridium aquilinum) are a traditional spring food of Native Americans, and are popular as a side dish in French cuisine. The licorice fern, Polypodium glycyrrhiza, is part of the diet of the Pacific Northwest coastal tribes, owing in part to the sweetness of its rhizomes. It has a faint licorice taste and serves as a sweetener. The rhizome also figures in the pharmacopeia of Native Americans for its medicinal properties and is used as a remedy for sore throat.
-Go to this website to learn how to identify fern species.By far the greatest impact of seedless vascular plants on human life, however, comes from their extinct progenitors. The tall club mosses, horsetails, and tree-like ferns that flourished in the swampy forests of the Carboniferous period gave rise to large deposits of coal throughout the world. Coal provided an abundant source of energy during the Industrial Revolution, which had tremendous consequences on human societies, including rapid technological progress and growth of large cities, as well as the degradation of the environment. Coal is still a prime source of energy and also a major contributor to global warming.
+Go to this website to learn how to identify fern species.By far the greatest impact of seedless vascular plants on human life, however, comes from their extinct progenitors. The tall club mosses, horsetails, and tree-like ferns that flourished in the swampy forests of the Carboniferous period gave rise to large deposits of coal throughout the world. Coal provided an abundant source of energy during the Industrial Revolution, which had tremendous consequences on human societies, including rapid technological progress and growth of large cities, as well as the degradation of the environment. Coal is still a prime source of energy and also a major contributor to global warming.Section SummaryThe seedless vascular plants show several features important to living on land: vascular tissue, roots, and leaves. Vascular systems consist of xylem tissue, which transports water and minerals, and phloem tissue, which transports sugars and proteins. With the development of the vascular system, leaves appeared to act as large photosynthetic organs, and roots to access water from the ground. Small uncomplicated leaves are termed microphylls. Large leaves with vein patterns are termed megaphylls. Modified leaves that bear sporangia are called sporophylls. Some sporophylls are arranged in cone structures called strobili.
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-
Beech inflorescences. The female inflorescence is at the upper left. The male inflorescence is at the lower right. (credit: Stephen J. Baskauf, 2002. http://bioimages.vanderbilt.edu/baskauf/10593. Morphbank :: Biological Imaging (http://www.morphbank.net/, 29 June 2017). Florida State University, Department of Scientific Computing, Tallahassee, FL 32306-4026 USA)
+
Beech inflorescences. The female inflorescence is at the upper left. The male inflorescence is at the lower right. (credit: Stephen J. Baskauf, 2002. http://bioimages.vanderbilt.edu/baskauf/10593. Morphbank :: Biological Imaging (http://www.morphbank.net/, 29 June 2017). Florida State University, Department of Scientific Computing, Tallahassee, FL 32306-4026 USA)
FruitAs the seed develops, the walls of the ovary thicken and form the fruit. The seed forms in an ovary, which also enlarges as the seeds grow. Many foods commonly called vegetables are actually fruits. Eggplants, zucchini, string beans, tomatoes, and bell peppers are all technically fruits because they contain seeds and are derived from the thick ovary tissue. Acorns are true nuts, and winged maple “helicopter seeds” or whirligigs (whose botanical name is samara) are also fruits. Botanists classify fruit into more than two dozen different categories, only a few of which are actually fleshy and sweet.
@@ -65,7 +65,7 @@
-
Magnolia grandiflora. A cluster of carpels can be seen above the stamens, which have shed their pollen and begun to drop from the inflorescence. In the flower, the sepals and petals are undifferentiated and are collectively called tepals. (credit: Ianaré Sévi. http://bioimages.vanderbilt.edu/baskauf/10949)
+
Magnolia grandiflora. A cluster of carpels can be seen above the stamens, which have shed their pollen and begun to drop from the inflorescence. In the flower, the sepals and petals are undifferentiated and are collectively called tepals. (credit: Ianaré Sévi. http://bioimages.vanderbilt.edu/baskauf/10949)
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Animals and Plants: PollinationFlowers pollinated by wind are usually small, feathery, and visually inconspicuous. Grasses are a successful group of flowering plants that are wind pollinated. They produce large amounts of powdery pollen carried over large distances by the wind. Some large trees such as oaks, maples, and birches are also wind pollinated.
-Explore this website for additional information on pollinators.
+Explore this website for additional information on pollinators.More than 80 percent of angiosperms depend on animals for pollination (technically the transfer of pollen from the anther to the stigma). Consequently, plants have developed many adaptations to attract pollinators. With over 200,000 different plants dependent on animal pollination, the plant needs to advertise to its pollinators with some specificity. The specificity of specialized plant structures that target animals can be very surprising. It is possible, for example, to determine the general type of pollinators favored by a plant by observing the flower’s physical characteristics. Many bird or insect-pollinated flowers secrete nectar, which is a sugary liquid. They also produce both fertile pollen, for reproduction, and sterile pollen rich in nutrients for birds and insects. Many butterflies and bees can detect ultraviolet light, and flowers that attract these pollinators usually display a pattern of ultraviolet reflectance that helps them quickly locate the flower's center. In this manner, pollinating insects collect nectar while at the same time are dusted with pollen (). Large, red flowers with little smell and a long funnel shape are preferred by hummingbirds, who have good color perception, a poor sense of smell, and need a strong perch. White flowers that open at night attract moths. Other animals—such as bats, lemurs, and lizards—can also act as pollinating agents. Any disruption to these interactions, such as the disappearance of bees, for example as a consequence of colony collapse disorders, can lead to disaster for agricultural industries that depend heavily on pollinated crops.
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The tissues of animals differ from those of the other major multicellular eukaryotes, plants and fungi, because their cells don't have cell walls. However, cells of animal tissues may be embedded in an extracellular matrix (e.g., mature bone cells reside within a mineralized organic matrix secreted by the cells). In vertebrates, bone tissue is a type of connective tissue that supports the entire body structure. The complex bodies and activities of vertebrates demand such supportive tissues. Epithelial tissues cover and protect both external and internal body surfaces, and may also have secretory functions. Epithelial tissues include the epidermis of the integument, the lining of the digestive tract and trachea, as well as the layers of cells that make up the ducts of the liver and glands of advanced animals, for example. The different types of tissues in true animals are responsible for carrying out specific functions for the organism. This differentiation and specialization of tissues is part of what allows for such incredible animal diversity.Just as there are multiple ways to be a eukaryote, there are multiple ways to be a multicellular animal. The animal kingdom is currently divided into five monophyletic clades: Parazoa or Porifera (sponges), Placozoa (tiny parasitic creatures that resemble multicellular amoebae), Cnidaria (jellyfish and their relatives), Ctenophora (the comb jellies), and Bilateria (all other animals). The Placozoa ("flat animal") and Parazoa (“beside animal”) do not have specialized tissues derived from germ layers of the embryo; although they do possess specialized cells that act functionally like tissues. The Placozoa have only four cell types, while the sponges have nearly two dozen. The three other clades do include animals with specialized tissues derived from the germ layers of the embryo. In spite of their superficial similarity to Cnidarian medusae, recent molecular studies indicate that the Ctenophores are only distantly related to the Cnidarians, which together with the Bilateria constitute the Eumetazoa ("true animals"). When we think of animals, we usually think of Eumetazoa, since most animals fall into this category.
-Watch a presentation by biologist E.O. Wilson on the importance of diversity.
+Watch a presentation by biologist E.O. Wilson on the importance of diversity.
@@ -51,7 +51,7 @@
Insect metamorphosis. (a) The grasshopper undergoes incomplete metamorphosis. (b) The butterfly undergoes complete metamorphosis. (credit: S.E. Snodgrass, USDA)
-Watch the following video to see how human embryonic development (after the blastula and gastrula stages of development) reflects evolution.
+Watch the following video to see how human embryonic development (after the blastula and gastrula stages of development) reflects evolution.
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Changes in the environment often create new niches (diversified living spaces) that invite rapid speciation and increased diversity. On the other hand, cataclysmic events, such as volcanic eruptions and meteor strikes that obliterate life, can result in devastating losses of diversity to some clades, yet provide new opportunities for others to “fill in the gaps” and speciate. Such periods of mass extinction () have occurred repeatedly in the evolutionary record of life, erasing some genetic lines while creating room for others to evolve into the empty niches left behind. The end of the Permian period (and the Paleozoic Era) was marked by the largest mass extinction event in Earth’s history, a loss of an estimated 95 percent of the extant species at that time. Some of the dominant phyla in the world’s oceans, such as the trilobites, disappeared completely. On land, the disappearance of some dominant species of Permian reptiles made it possible for a new line of reptiles to emerge, the dinosaurs. The warm and stable climatic conditions of the ensuing Mesozoic Era promoted an explosive diversification of dinosaurs into every conceivable niche in land, air, and water. Plants, too, radiated into new landscapes and empty niches, creating complex communities of producers and consumers, some of which became very large on the abundant food available.Another mass extinction event occurred at the end of the Cretaceous period, bringing the Mesozoic Era to an end. Skies darkened and temperatures fell after a large meteor impact and tons of volcanic ash ejected into the atmosphere blocked incoming sunlight. Plants died, herbivores and carnivores starved, and the dinosaurs ceded their dominance of the landscape to the more warm-blooded mammals. In the following Cenozoic Era, mammals radiated into terrestrial and aquatic niches once occupied by dinosaurs, and birds—the warm-blooded direct descendants of one line of the ruling reptiles—became aerial specialists. The appearance and dominance of flowering plants in the Cenozoic Era created new niches for pollinating insects, as well as for birds and mammals. Changes in animal species diversity during the late Cretaceous and early Cenozoic were also promoted by a dramatic shift in Earth’s geography, as continental plates slid over the crust into their current positions, leaving some animal groups isolated on islands and continents, or separated by mountain ranges or inland seas from other competitors. Early in the Cenozoic, new ecosystems appeared, with the evolution of grasses and coral reefs. Late in the Cenozoic, further extinctions followed by speciation occurred during ice ages that covered high latitudes with ice and then retreated, leaving new open spaces for colonization.
-Watch the following video to learn more about the mass extinctions.
+Watch the following video to learn more about the mass extinctions.
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-
Whale shark in the Georgia Aquarium. Whale sharks are filter-feeders and can grow to be over 10 meters long. Whale sharks, like most other sharks, are ovoviviparous. (credit: modified from Zac Wolf [Own work] [CC BY-SA 2.5 (http://creativecommons.org/licenses/by-sa/2.5)], via Wikimedia Commons)
Sharks reproduce sexually, and eggs are fertilized internally. Most species are ovoviviparous: The fertilized egg is retained in the oviduct of the mother’s body and the embryo is nourished by the egg yolk. The eggs hatch in the uterus, and young are born alive and fully functional. Some species of sharks are oviparous: They lay eggs that hatch outside of the mother’s body. Embryos are protected by a shark egg case or “mermaid’s purse” () that has the consistency of leather. The shark egg case has tentacles that snag in seaweed and give the newborn shark cover. A few species of sharks, e.g., tiger sharks and hammerheads, are viviparous: the yolk sac that initially contains the egg yolk and transfers its nutrients to the growing embryo becomes attached to the oviduct of the female, and nutrients are transferred directly from the mother to the growing embryo. In both viviparous and ovoviviparous sharks, gas exchange uses this yolk sac transport.
+
Whale shark in the Georgia Aquarium. Whale sharks are filter-feeders and can grow to be over 10 meters long. Whale sharks, like most other sharks, are ovoviviparous. (credit: modified from Zac Wolf [Own work] [CC BY-SA 2.5 (http://creativecommons.org/licenses/by-sa/2.5)], via Wikimedia Commons)
Sharks reproduce sexually, and eggs are fertilized internally. Most species are ovoviviparous: The fertilized egg is retained in the oviduct of the mother’s body and the embryo is nourished by the egg yolk. The eggs hatch in the uterus, and young are born alive and fully functional. Some species of sharks are oviparous: They lay eggs that hatch outside of the mother’s body. Embryos are protected by a shark egg case or “mermaid’s purse” () that has the consistency of leather. The shark egg case has tentacles that snag in seaweed and give the newborn shark cover. A few species of sharks, e.g., tiger sharks and hammerheads, are viviparous: the yolk sac that initially contains the egg yolk and transfers its nutrients to the growing embryo becomes attached to the oviduct of the female, and nutrients are transferred directly from the mother to the growing embryo. In both viviparous and ovoviviparous sharks, gas exchange uses this yolk sac transport.
diff --git a/modules/m66590/index.cnxml b/modules/m66590/index.cnxml
index 17f963be5..b23e678fa 100644
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Evolution of AmphibiansThe fossil record provides evidence of the first tetrapods: now-extinct amphibian species dating to nearly 400 million years ago. Evolution of tetrapods from lobe-finned freshwater fishes (similar to coelacanths and lungfish) represented a significant change in body plan from one suited to organisms that respired and swam in water, to organisms that breathed air and moved onto land; these changes occurred over a span of 50 million years during the Devonian period.Aquatic tetrapods of the Devonian period include Ichthyostega and Acanthostega. Both were aquatic, and may have had both gills and lungs. They also had four limbs, with the skeletal structure of limbs found in present-day tetrapods, including amphibians. However, the limbs could not be pulled in under the body and would not have supported their bodies well out of water. They probably lived in shallow freshwater environments, and may have taken brief terrestrial excursions, much like “walking” catfish do today in Florida. In Ichthyostega, the forelimbs were more developed than the hind limbs, so it might have dragged itself along when it ventured onto land. What preceded Acanthostega and Ichthyostega?
-In 2006, researchers published news of their discovery of a fossil of a “tetrapod-like fish,” Tiktaalik roseae, which seems to be a morphologically “intermediate form” between sarcopterygian fishes having feet-like fins and early tetrapods having true limbs (). Tiktaalik likely lived in a shallow water environment about 375 million years ago.Daeschler, E. B., Shubin, N. H., and Jenkins, F. J. “A Devonian tetrapod-like fish and the evolution of the tetrapod body plan,” Nature 440 (2006): 757–763, doi:10.1038/nature04639, http://www.nature.com/nature/journal/v440/n7085/abs/nature04639.html. Tiktaalik also had gills and lungs, but the loss of some gill elements gave it a neck, which would have allowed its head to move sideways for feeding. The eyes were on top of the head. It had fins, but the attachment of the fin bones to the shoulder suggested they might be weight-bearing. Tiktaalik preceded Acanthostega and Ichthyostega, with their four limbs, by about 10 million years and is considered to be a true intermediate clade between fish and amphibians.
+In 2006, researchers published news of their discovery of a fossil of a “tetrapod-like fish,” Tiktaalik roseae, which seems to be a morphologically “intermediate form” between sarcopterygian fishes having feet-like fins and early tetrapods having true limbs (). Tiktaalik likely lived in a shallow water environment about 375 million years ago.Daeschler, E. B., Shubin, N. H., and Jenkins, F. J. “A Devonian tetrapod-like fish and the evolution of the tetrapod body plan,” Nature 440 (2006): 757–763, doi:10.1038/nature04639, http://www.nature.com/nature/journal/v440/n7085/abs/nature04639.html. Tiktaalik also had gills and lungs, but the loss of some gill elements gave it a neck, which would have allowed its head to move sideways for feeding. The eyes were on top of the head. It had fins, but the attachment of the fin bones to the shoulder suggested they might be weight-bearing. Tiktaalik preceded Acanthostega and Ichthyostega, with their four limbs, by about 10 million years and is considered to be a true intermediate clade between fish and amphibians.
@@ -67,7 +67,7 @@
Salamander. Most salamanders have legs and a tail, but respiration varies among species. (credit: Valentina Storti)
-View River Monsters: Fish With Arms and Hands? to see a video about an unusually large salamander species.
+View River Monsters: Fish With Arms and Hands? to see a video about an unusually large salamander species.Anura: FrogsFrogs () are amphibians that belong to the order Anura or Salientia ("jumpers"). Anurans are among the most diverse groups of vertebrates, with approximately 5,965 species that occur on all of the continents except Antarctica. Anurans, ranging from the minute New Guinea frog at 7 mm to the huge goliath frog at 32 cm from tropical Africa, have a body plan that is more specialized for movement. Adult frogs use their hind limbs and their arrow-like endoskeleton to jump accurately to capture prey on land. Tree frogs have hands adapted for grasping branches as they climb. In tropical areas, “flying frogs” can glide from perch to perch on the extended webs of their feet. Frogs have a number of modifications that allow them to avoid predators, including skin that acts as camouflage. Many species of frogs and salamanders also release defensive chemicals that are poisonous to predators from glands in the skin. Frogs with more toxic skins have bright warning (aposematic) coloration.
@@ -93,7 +93,7 @@
As plants became more common through the latter half of the Paleozoic, microclimates began to emerge and ecosystems began to change. As plants and ecosystems continued to grow and become more complex, vertebrates moved from the water to land. The presence of shoreline vegetation may have contributed to the movement of vertebrates onto land. One hypothesis suggests that the fins of aquatic vertebrates were used to maneuver through this vegetation, providing a precursor to the movement of fins on land and the further development of limbs. The late Paleozoic was a time of diversification of vertebrates, as amniotes emerged and became two different lines that gave rise, on one hand, to synapsids and mammals, and, on the other hand, to the codonts, reptiles, dinosaurs, and birds. Many marine vertebrates became extinct near the end of the Devonian period, which ended about 360 million years ago, and both marine and terrestrial vertebrates were decimated by a mass extinction in the early Permian period about 250 million years ago.
-View Earth’s Paleogeography: Continental Movements Through Time to see changes in Earth as life evolved.
+View Earth’s Paleogeography: Continental Movements Through Time to see changes in Earth as life evolved.Section Summary
diff --git a/modules/m66591/index.cnxml b/modules/m66591/index.cnxml
index a9494189e..f233c2a70 100644
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Ornithischian and saurischian Dinosaurs. Edmontonia was an armored dinosaur that lived in the Late Cretaceous period, 145.5 to 65.6 million years ago. Herrerasaurus and Eoraptor (b) were late Triassic saurischian dinosaurs dating to about 230 million years ago. (credit: a Mariana Ruiz Villareal b Zach Tirrell from Plymouth, USA, Dino Origins)
Dinosaurs dominated the Mesozoic era, which was known as the “Age of Reptiles.” The dominance of dinosaurs lasted until the end of the Cretaceous, the last period of the Mesozoic era. The Cretaceous-Tertiary extinction resulted in the loss of most of the large-bodied animals of the Mesozoic era. Birds are the only living descendants of one of the major clades of theropod dinosaurs.
-Visit this site to see a video discussing the hypothesis that an asteroid caused the Cretaceous-Triassic (KT) extinction.
+Visit this site to see a video discussing the hypothesis that an asteroid caused the Cretaceous-Triassic (KT) extinction.Modern Reptiles
diff --git a/modules/m66592/index.cnxml b/modules/m66592/index.cnxml
index efbeadfd8..f7b7c1257 100644
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@@ -22,7 +22,7 @@
-
Flight feathers. (a) Primary feathers are located at the wing tip and provide thrust; secondary feathers are located close to the body and provide lift. (b) Primary and secondary feathers from a common buzzard (Buteo buteo). (Credit b: Mod. from S. Seyfert https://commons.wikimedia.org/w/index.php?curid=613813)
Flapping of the entire wing occurs primarily through the actions of the chest muscles: Specifically, the contraction of the pectoralis major muscles moves the wings downward (downstroke), whereas contraction of the supracoracoideus muscles moves the wings upward (upstroke) via a tough tendon that passes over the coracoid bone and the top of the humerus. Both muscles are attached to the keel of the sternum, and these are the muscles that humans eat on holidays (this is why the back of the bird offers little meat!). These muscles are highly developed in birds and account for a higher percentage of body mass than in most mammals. The flight muscles attach to a blade-shaped keel projecting ventrally from the sternum, like the keel of a boat. The sternum of birds is deeper than that of other vertebrates, which accommodates the large flight muscles. The flight muscles of birds who are active flyers are rich with oxygen-storing myoglobin. Another skeletal modification found in most birds is the fusion of the two clavicles (collarbones), forming the furcula or wishbone. The furcula is flexible enough to bend and provide support to the shoulder girdle during flapping.
+
Flight feathers. (a) Primary feathers are located at the wing tip and provide thrust; secondary feathers are located close to the body and provide lift. (b) Primary and secondary feathers from a common buzzard (Buteo buteo). (Credit b: Mod. from S. Seyfert https://commons.wikimedia.org/w/index.php?curid=613813)
Flapping of the entire wing occurs primarily through the actions of the chest muscles: Specifically, the contraction of the pectoralis major muscles moves the wings downward (downstroke), whereas contraction of the supracoracoideus muscles moves the wings upward (upstroke) via a tough tendon that passes over the coracoid bone and the top of the humerus. Both muscles are attached to the keel of the sternum, and these are the muscles that humans eat on holidays (this is why the back of the bird offers little meat!). These muscles are highly developed in birds and account for a higher percentage of body mass than in most mammals. The flight muscles attach to a blade-shaped keel projecting ventrally from the sternum, like the keel of a boat. The sternum of birds is deeper than that of other vertebrates, which accommodates the large flight muscles. The flight muscles of birds who are active flyers are rich with oxygen-storing myoglobin. Another skeletal modification found in most birds is the fusion of the two clavicles (collarbones), forming the furcula or wishbone. The furcula is flexible enough to bend and provide support to the shoulder girdle during flapping.An important requirement for flight is a low body weight. As body weight increases, the muscle output required for flying increases. The largest living bird is the ostrich, and while it is much smaller than the largest mammals, it is secondarily flightless. For birds that do fly, reduction in body weight makes flight easier. Several modifications are found in birds to reduce body weight, including pneumatization of bones. Pneumatic bones () are bones that are hollow, rather than filled with tissue; cross struts of bone called trabeculae provide structural reinforcement. Pneumatic bones are not found in all birds, and they are more extensive in large birds than in small birds. Not all bones of the skeleton are pneumatic, although the skulls of almost all birds are. The jaw is also lightened by the replacement of heavy jawbones and teeth with a beak made of keratin (just as hair, scales, and feathers are).
@@ -51,7 +51,7 @@
There are two basic hypotheses that explain how flight may have evolved in birds: the arboreal (“tree”) hypothesis and the terrestrial (“land”) hypothesis. The arboreal hypothesis posits that tree-dwelling precursors to modern birds jumped from branch to branch using their feathers for gliding before becoming fully capable of flapping flight. In contrast to this, the terrestrial hypothesis holds that running (perhaps pursuing active prey such as small cursorial animals) was the stimulus for flight. In this scenario, wings could be used to capture prey and were preadapted for balance and flapping flight. Ostriches, which are large flightless birds, hold their wings out when they run, possibly for balance. However, this condition may represent a behavioral relict of the clade of flying birds that were their ancestors. It seems more likely that small feathered arboreal dinosaurs, were capable of gliding (and flapping) from tree to tree and branch to branch, improving the chances of escaping enemies, finding mates, and obtaining prey such as flying insects. This early flight behavior would have also greatly increased the opportunity for species dispersal.Although we have a good understanding of how feathers and flight may have evolved, the question of how endothermy evolved in birds (and other lineages) remains unanswered. Feathers provide insulation, but this is only beneficial for thermoregulatory purposes if body heat is being produced internally. Similarly, internal heat production is only viable for the evolution of endothermy if insulation is present to retain that infrared energy. It has been suggested that one or the other—feathers or endothermy—evolved first in response to some other selective pressure (e.g., the ability to be active at night, provide camouflage, repel water, or serve as signals for mate selection). It seems probable that feathers and endothermy coevolved together, the improvement and evolutionary advancement of feathers reinforcing the evolutionary advancement of endothermy, and so on.During the Cretaceous period (145 to 66 MYA), a group known as the Enantiornithes was the dominant bird type (). Enantiornithes means “opposite birds,” which refers to the fact that certain bones of the shoulder are joined differently than the way the bones are joined in modern birds. Like Archaeopteryx, these birds retained teeth in their jaws, but did have a shortened tail, and at least some fossils have preserved “fans” of tail feathers. These birds formed an evolutionary lineage separate from that of modern birds, and they did not survive past the Cretaceous. Along with the Enantiornithes, however, another group of birds—the Ornithurae ("bird tails"), with a short, fused tail or pygostyle—emerged from the evolutionary line that includes modern birds. This clade was also present in the Cretaceous.
-After the extinction of Enantiornithes, the Ornithurae became the dominant birds, with a large and rapid radiation occurring after the extinction of the dinosaurs during the Cenozoic era (66 MYA to the present). Molecular analysis based on very large data sets has produced our current understanding of the relationships among living birds. There are three major clades: the Paleognathae, the Galloanserae, and the Neoaves. The Paleognathae (“old jaw”) or ratites (polyphyletic) are a group of flightless birds including ostriches, emus, rheas, and kiwis. The Galloanserae include pheasants, ducks, geese and swans. The Neoaves ("new birds") includes all other birds. The Neoaves themselves have been distributed among five clades:Prum, RO et al. 2015. A comprehensive phylogeny of birds (Aves) using targeted next-generation DNA sequencing. Nature 526: 569 - 573. http://dx.doi.org/10.1038/nature15697 Strisores (nightjars, swifts, and hummingbirds), Columbaves (turacos, bustards, cuckoos, pigeons, and doves), Gruiformes (cranes), Aequorlitornithes (diving birds, wading birds, and shorebirds), and Inopinaves (a very large clade of land birds including hawks, owls, woodpeckers, parrots, falcons, crows, and songbirds). Despite the current classification scheme, it is important to understand that phylogenetic revisions, even for the extant birds, are still taking place.
+After the extinction of Enantiornithes, the Ornithurae became the dominant birds, with a large and rapid radiation occurring after the extinction of the dinosaurs during the Cenozoic era (66 MYA to the present). Molecular analysis based on very large data sets has produced our current understanding of the relationships among living birds. There are three major clades: the Paleognathae, the Galloanserae, and the Neoaves. The Paleognathae (“old jaw”) or ratites (polyphyletic) are a group of flightless birds including ostriches, emus, rheas, and kiwis. The Galloanserae include pheasants, ducks, geese and swans. The Neoaves ("new birds") includes all other birds. The Neoaves themselves have been distributed among five clades:Prum, RO et al. 2015. A comprehensive phylogeny of birds (Aves) using targeted next-generation DNA sequencing. Nature 526: 569 - 573. http://dx.doi.org/10.1038/nature15697 Strisores (nightjars, swifts, and hummingbirds), Columbaves (turacos, bustards, cuckoos, pigeons, and doves), Gruiformes (cranes), Aequorlitornithes (diving birds, wading birds, and shorebirds), and Inopinaves (a very large clade of land birds including hawks, owls, woodpeckers, parrots, falcons, crows, and songbirds). Despite the current classification scheme, it is important to understand that phylogenetic revisions, even for the extant birds, are still taking place.
Enantiornithean bird. Shanweiniao cooperorum was a species of Enantiornithes that did not survive past the Cretaceous period. (credit: Nobu Tamura)
A morganucodont. This morganucodont Megazotrodon, an extinct basal mammal, may have been nocturnal and insectivorous. Inset: Jaw of a morganucodont, showing a double hinge, one between the dentary and squamosal and one between the articular (yellow) and quadrate (blue) bones. In living mammals, the articular and quadrate bones have been incorporated into the middle ear. (Credit: By Nordelch [Megazostrodon Natural History Museum] Wikimedia Commons. Credit inset: Mod from Philcha. https://commons.wikimedia.org/w/index.php? curid=3631949)
+
A morganucodont. This morganucodont Megazotrodon, an extinct basal mammal, may have been nocturnal and insectivorous. Inset: Jaw of a morganucodont, showing a double hinge, one between the dentary and squamosal and one between the articular (yellow) and quadrate (blue) bones. In living mammals, the articular and quadrate bones have been incorporated into the middle ear. (Credit: By Nordelch [Megazostrodon Natural History Museum] Wikimedia Commons. Credit inset: Mod from Philcha. https://commons.wikimedia.org/w/index.php? curid=3631949)
Living MammalsThere are three major groups of living mammals: monotremes (prototheria), marsupials (metatheria), and placental (eutheria) mammals. The eutherians and the marsupials together comprise a clade of therian mammals, with the monotremes forming a sister clade to both metatherians and eutherians.
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-
A Philippine tarsier. This tarsier, Carlito syrichta, is one of the smallest primates—about 5 inches long, from nose to the base of the tail. The tail is not shown, but is about twice the length of the body. Note the large eyes, each of which is about the same size as the animal's brain, and the long hind legs. (credit: mtoz (http://creativecommons.org/licenses/by-sa/2.0), via Wikimedia Commons)
+
A Philippine tarsier. This tarsier, Carlito syrichta, is one of the smallest primates—about 5 inches long, from nose to the base of the tail. The tail is not shown, but is about twice the length of the body. Note the large eyes, each of which is about the same size as the animal's brain, and the long hind legs. (credit: mtoz (http://creativecommons.org/licenses/by-sa/2.0), via Wikimedia Commons)
Evolution of PrimatesThe first primate-like mammals are referred to as proto-primates. They were roughly similar to squirrels and tree shrews in size and appearance. The existing fossil evidence (mostly from North Africa) is very fragmented. These proto-primates remain largely mysterious creatures until more fossil evidence becomes available. Although genetic evidence suggests that primates diverged from other mammals about 85 MYA, the oldest known primate-like mammals with a relatively robust fossil record date to about 65 MYA. Fossils like the proto-primate Plesiadapis (although some researchers do not agree that Plesiadapis was a proto-primate) had some features of the teeth and skeleton in common with true primates. They were found in North America and Europe in the Cenozoic and went extinct by the end of the Eocene.
diff --git a/modules/m66596/index.cnxml b/modules/m66596/index.cnxml
index 73f9fccab..cb151f327 100644
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Like animals, plants contain cells with organelles in which specific metabolic activities take place. Unlike animals, however, plants use energy from sunlight to form sugars during photosynthesis. In addition, plant cells have cell walls, plastids, and a large central vacuole: structures that are not found in animal cells. Each of these cellular structures plays a specific role in plant structure and function.
-Watch Botany Without Borders, a video produced by the Botanical Society of America about the importance of plants.
+Watch Botany Without Borders, a video produced by the Botanical Society of America about the importance of plants.Plant Organ SystemsIn plants, just as in animals, similar cells working together form a tissue. When different types of tissues work together to perform a unique function, they form an organ; organs working together form organ systems. Vascular plants have two distinct organ systems: a shoot system, and a root system. The shoot system consists of two portions: the vegetative (non-reproductive) parts of the plant, such as the leaves and the stems, and the reproductive parts of the plant, which include flowers and fruits. The shoot system generally grows above ground, where it absorbs the light needed for photosynthesis. The root system, which supports the plants and absorbs water and minerals, is usually underground. shows the organ systems of a typical plant.
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index 42cdf9162..199ee5b5f 100644
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Most primary growth occurs at the apices, or tips, of stems and roots. Primary growth is a result of rapidly dividing cells in the apical meristems at the shoot tip and root tip. Subsequent cell elongation also contributes to primary growth. The growth of shoots and roots during primary growth enables plants to continuously seek water (roots) or sunlight (shoots).The influence of the apical bud on overall plant growth is known as apical dominance, which diminishes the growth of axillary buds that form along the sides of branches and stems. Most coniferous trees exhibit strong apical dominance, thus producing the typical conical Christmas tree shape. If the apical bud is removed, then the axillary buds will start forming lateral branches. Gardeners make use of this fact when they prune plants by cutting off the tops of branches, thus encouraging the axillary buds to grow out, giving the plant a bushy shape.
-Watch this BBC Nature video showing how time-lapse photography captures plant growth at high speed.
+Watch this BBC Nature video showing how time-lapse photography captures plant growth at high speed.Secondary Growth
@@ -109,7 +109,7 @@
Stem modifications enable plants to thrive in a variety of environments. Shown are (a) ginger (Zingiber officinale) rhizomes, (b) a carrion flower (Amorphophallus titanum) corm, (c) Rhodes grass (Chloris gayana) stolons, (d) strawberry (Fragaria ananassa) runners, (e) potato (Solanum tuberosum) tubers, and (f) red onion (Allium) bulbs. (credit a: modification of work by Maja Dumat; credit c: modification of work by Harry Rose; credit d: modification of work by Rebecca Siegel; credit e: modification of work by Scott Bauer, USDA ARS; credit f: modification of work by Stephen Ausmus, USDA ARS)
-Watch botanist Wendy Hodgson, of Desert Botanical Garden in Phoenix, Arizona, explain how agave plants were cultivated for food hundreds of years ago in the Arizona desert in this video: Finding the Roots of an Ancient Crop.
+Watch botanist Wendy Hodgson, of Desert Botanical Garden in Phoenix, Arizona, explain how agave plants were cultivated for food hundreds of years ago in the Arizona desert in this video: Finding the Roots of an Ancient Crop.Some aerial modifications of stems are tendrils and thorns (). Tendrils are slender, twining strands that enable a plant (like a vine or pumpkin) to seek support by climbing on other surfaces. Thorns are modified branches appearing as sharp outgrowths that protect the plant; common examples include roses, Osage orange, and devil’s walking stick.
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This scanning electron micrograph shows xylem and phloem in the leaf vascular bundle from the lyre-leaved sand cress (Arabidopsis lyrata). (credit: modification of work by Robert R. Wise; scale-bar data from Matt Russell)
Leaf AdaptationsConiferous plant species that thrive in cold environments, like spruce, fir, and pine, have leaves that are reduced in size and needle-like in appearance. These needle-like leaves have sunken stomata and a smaller surface area: two attributes that aid in reducing water loss. In hot climates, plants such as cacti have leaves that are reduced to spines, which in combination with their succulent stems, help to conserve water. Many aquatic plants have leaves with wide lamina that can float on the surface of the water, and a thick waxy cuticle on the leaf surface that repels water.
-Watch “The Pale Pitcher Plant” episode of the video series Plants Are Cool, Too, a Botanical Society of America video about a carnivorous plant species found in Louisiana.
+Watch “The Pale Pitcher Plant” episode of the video series Plants Are Cool, Too, a Botanical Society of America video about a carnivorous plant species found in Louisiana.Plant Adaptations in Resource-Deficient EnvironmentsRoots, stems, and leaves are structured to ensure that a plant can obtain the required sunlight, water, soil nutrients, and oxygen resources. Some remarkable adaptations have evolved to enable plant species to thrive in less than ideal habitats, where one or more of these resources is in short supply.
diff --git a/modules/m66601/index.cnxml b/modules/m66601/index.cnxml
index 83d103443..4843769f6 100644
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@@ -50,7 +50,7 @@
Azure bluets (Houstonia caerulea) display a phototropic response by bending toward the light. (credit: Cory Zanker)
In 1913, Peter Boysen-Jensen demonstrated that a chemical signal produced in the plant tip was responsible for the bending at the base. He cut off the tip of a seedling, covered the cut section with a layer of gelatin, and then replaced the tip. The seedling bent toward the light when illuminated. However, when impermeable mica flakes were inserted between the tip and the cut base, the seedling did not bend. A refinement of the experiment showed that the signal traveled on the shaded side of the seedling. When the mica plate was inserted on the illuminated side, the plant did bend towards the light. Therefore, the chemical signal was a growth stimulant because the phototropic response involved faster cell elongation on the shaded side than on the illuminated side. We now know that as light passes through a plant stem, it is diffracted and generates phototropin activation across the stem. Most activation occurs on the lit side, causing the plant hormone indole acetic acid (IAA) to accumulate on the shaded side. Stem cells elongate under influence of IAA.Cryptochromes are another class of blue-light absorbing photoreceptors that also contain a flavin-based chromophore. Cryptochromes set the plants' 24-hour activity cycle, also known as its circadian rhythm, using blue light cues. There is some evidence that cryptochromes work together with phototropins to mediate the phototropic response.
-Use the navigation menu in the left panel of this website to view images of plants in motion.
+Use the navigation menu in the left panel of this website to view images of plants in motion.
@@ -104,7 +104,7 @@
The shoot of a pea plant winds around a trellis, while a tree grows on an angle in response to strong prevailing winds. These are examples of how plants respond to touch or wind.The movement of a plant subjected to constant directional pressure is called thigmotropism, from the Greek words thigma meaning “touch,” and tropism implying “direction.” Tendrils are one example of this. The meristematic region of tendrils is very touch sensitive; light touch will evoke a quick coiling response. Cells in contact with a support surface contract, whereas cells on the opposite side of the support expand (). Application of jasmonic acid is sufficient to trigger tendril coiling without a mechanical stimulus.A thigmonastic response is a touch response independent of the direction of stimulus . In the Venus flytrap, two modified leaves are joined at a hinge and lined with thin fork-like tines along the outer edges. Tiny hairs are located inside the trap. When an insect brushes against these trigger hairs, touching two or more of them in succession, the leaves close quickly, trapping the prey. Glands on the leaf surface secrete enzymes that slowly digest the insect. The released nutrients are absorbed by the leaves, which reopen for the next meal.Thigmomorphogenesis is a slow developmental change in the shape of a plant subjected to continuous mechanical stress. When trees bend in the wind, for example, growth is usually stunted and the trunk thickens. Strengthening tissue, especially xylem, is produced to add stiffness to resist the wind’s force. Researchers hypothesize that mechanical strain induces growth and differentiation to strengthen the tissues. Ethylene and jasmonate are likely involved in thigmomorphogenesis.
-Use the menu at the left to navigate to three short movies: a Venus fly trap capturing prey, the progressive closing of sensitive plant leaflets, and the twining of tendrils.
+Use the menu at the left to navigate to three short movies: a Venus fly trap capturing prey, the progressive closing of sensitive plant leaflets, and the twining of tendrils.Defense Responses against Herbivores and Pathogens
diff --git a/modules/m66603/index.cnxml b/modules/m66603/index.cnxml
index f3b09af87..21411c19a 100644
--- a/modules/m66603/index.cnxml
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@@ -97,7 +97,7 @@
In addition to macronutrients, organisms require various elements in small amounts. These micronutrients, or trace elements, are present in very small quantities. They include boron (B), chlorine (Cl), manganese (Mn), iron (Fe), zinc (Zn), copper (Cu), molybdenum (Mo), nickel (Ni), silicon (Si), and sodium (Na).Deficiencies in any of these nutrients—particularly the macronutrients—can adversely affect plant growth (); depending on the specific nutrient, a lack can cause stunted growth, slow growth, or chlorosis (yellowing of the leaves). Extreme deficiencies may result in leaves showing signs of cell death.
-Visit this website to participate in an interactive experiment on plant nutrient deficiencies. You can adjust the amounts of N, P, K, Ca, Mg, and Fe that plants receive . . . and see what happens.
+Visit this website to participate in an interactive experiment on plant nutrient deficiencies. You can adjust the amounts of N, P, K, Ca, Mg, and Fe that plants receive . . . and see what happens.
diff --git a/modules/m66604/index.cnxml b/modules/m66604/index.cnxml
index 013654ff1..5f132cf1a 100644
--- a/modules/m66604/index.cnxml
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@@ -34,7 +34,7 @@
The organic material of soil, called humus, is made up of microorganisms (dead and alive), and dead animals and plants in varying stages of decay. Humus improves soil structure and provides plants with water and minerals. The inorganic material of soil consists of rock, slowly broken down into smaller particles that vary in size. Soil particles that are 0.1 to 2 mm in diameter are sand. Soil particles between 0.002 and 0.1 mm are called silt, and even smaller particles, less than 0.002 mm in diameter, are called clay. Some soils have no dominant particle size and contain a mixture of sand, silt, and humus; these soils are called loams.
-Explore this interactive map from the USDA’s National Cooperative Soil Survey to access soil data for almost any region in the United States.
+Explore this interactive map from the USDA’s National Cooperative Soil Survey to access soil data for almost any region in the United States.Soil Formation
@@ -79,7 +79,7 @@
-
This soil scientist is studying the horizons and composition of soil at a research site. (credit: USDA)
Many soil scientists work both in an office and in the field. According to the United States Department of Agriculture (USDA): “a soil scientist needs good observation skills to analyze and determine the characteristics of different types of soils. Soil types are complex and the geographical areas a soil scientist may survey are varied. Aerial photos or various satellite images are often used to research the areas. Computer skills and geographic information systems (GIS) help the scientist to analyze the multiple facets of geomorphology, topography, vegetation, and climate to discover the patterns left on the landscape.”National Resources Conservation Service / United States Department of Agriculture. “Careers in Soil Science.” http://openstax.org/l/NRCS Soil scientists play a key role in understanding the soil’s past, analyzing present conditions, and making recommendations for future soil-related practices.
+
This soil scientist is studying the horizons and composition of soil at a research site. (credit: USDA)
Many soil scientists work both in an office and in the field. According to the United States Department of Agriculture (USDA): “a soil scientist needs good observation skills to analyze and determine the characteristics of different types of soils. Soil types are complex and the geographical areas a soil scientist may survey are varied. Aerial photos or various satellite images are often used to research the areas. Computer skills and geographic information systems (GIS) help the scientist to analyze the multiple facets of geomorphology, topography, vegetation, and climate to discover the patterns left on the landscape.”National Resources Conservation Service / United States Department of Agriculture. “Careers in Soil Science.” https://openstax.org/l/NRCS Soil scientists play a key role in understanding the soil’s past, analyzing present conditions, and making recommendations for future soil-related practices.Section SummaryPlants obtain mineral nutrients from the soil. Soil is the outer loose layer that covers the surface of Earth. Soil quality depends on the chemical composition of the soil, the topography, the presence of living organisms, the climate, and time. Agricultural practice and history may also modify the characteristics and fertility of soil. Soil consists of four major components: 1) inorganic mineral matter, 2) organic matter, 3) water and air, and 4) living matter. The organic material of soil is made of humus, which improves soil structure and provides water and minerals. Soil inorganic material consists of rock slowly broken down into smaller particles that vary in size, such as sand, silt, and loam.Soil formation results from a combination of biological, physical, and chemical processes. Soil is not homogenous because its formation results in the production of layers called a soil profile. Factors that affect soil formation include: parent material, climate, topography, biological factors, and time. Soils are classified based on their horizons, soil particle size, and proportions. Most soils have four distinct horizons: O, A, B, and C.
diff --git a/modules/m66605/index.cnxml b/modules/m66605/index.cnxml
index 252f82c1e..8b4dc2089 100644
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@@ -17,7 +17,7 @@
Plants obtain food in two different ways. Autotrophic plants can make their own food from inorganic raw materials, such as carbon dioxide and water, through photosynthesis in the presence of sunlight. Green plants are included in this group. Some plants, however, are heterotrophic: they are totally parasitic and lacking in chlorophyll. These plants, referred to as holo-parasitic plants, are unable to synthesize organic carbon and draw all of their nutrients from the host plant.Plants may also enlist the help of microbial partners in nutrient acquisition. Particular species of bacteria and fungi have evolved along with certain plants to create a mutualistic symbiotic relationship with roots. This improves the nutrition of both the plant and the microbe. The formation of nodules in legume plants and mycorrhization can be considered among the nutritional adaptations of plants. However, these are not the only type of adaptations that we may find; many plants have other adaptations that allow them to thrive under specific conditions.
-This video reviews basic concepts about photosynthesis. In the left panel, click each tab to select a topic for review.
+This video reviews basic concepts about photosynthesis. In the left panel, click each tab to select a topic for review.Nitrogen Fixation: Root and Bacteria InteractionsNitrogen is an important macronutrient because it is part of nucleic acids and proteins. Atmospheric nitrogen, which is the diatomic molecule N2, or dinitrogen, is the largest pool of nitrogen in terrestrial ecosystems. However, plants cannot take advantage of this nitrogen because they do not have the necessary enzymes to convert it into biologically useful forms. However, nitrogen can be “fixed,” which means that it can be converted to ammonia (NH3) through biological, physical, or chemical processes. As you have learned, biological nitrogen fixation (BNF) is the conversion of atmospheric nitrogen (N2) into ammonia (NH3), exclusively carried out by prokaryotes such as soil bacteria or cyanobacteria. Biological processes contribute 65 percent of the nitrogen used in agriculture. The following equation represents the process:
diff --git a/modules/m66608/index.cnxml b/modules/m66608/index.cnxml
index ca1b995c4..0b4195858 100644
--- a/modules/m66608/index.cnxml
+++ b/modules/m66608/index.cnxml
@@ -18,7 +18,7 @@
In angiosperms, pollination is defined as the placement or transfer of pollen from the anther to the stigma of the same flower or another flower. In gymnosperms, pollination involves pollen transfer from the male cone to the female cone. Upon transfer, the pollen germinates to form the pollen tube and the sperm for fertilizing the egg. Pollination has been well studied since the time of Gregor Mendel. Mendel successfully carried out self- as well as cross-pollination in garden peas while studying how characteristics were passed on from one generation to the next. Today’s crops are a result of plant breeding, which employs artificial selection to produce the present-day cultivars. A case in point is today's corn, which is a result of years of breeding that started with its ancestor, teosinte. The teosinte that the ancient Mayans originally began cultivating had tiny seeds—vastly different from today’s relatively giant ears of corn. Interestingly, though these two plants appear to be entirely different, the genetic difference between them is miniscule.Pollination takes two forms: self-pollination and cross-pollination. Self-pollination occurs when the pollen from the anther is deposited on the stigma of the same flower, or another flower on the same plant. Cross-pollination is the transfer of pollen from the anther of one flower to the stigma of another flower on a different individual of the same species. Self-pollination occurs in flowers where the stamen and carpel mature at the same time, and are positioned so that the pollen can land on the flower’s stigma. This method of pollination does not require an investment from the plant to provide nectar and pollen as food for pollinators.
-Explore this interactive website to review self-pollination and cross-pollination.Living species are designed to ensure survival of their progeny; those that fail become extinct. Genetic diversity is therefore required so that in changing environmental or stress conditions, some of the progeny can survive. Self-pollination leads to the production of plants with less genetic diversity, since genetic material from the same plant is used to form gametes, and eventually, the zygote. In contrast, cross-pollination—or out-crossing—leads to greater genetic diversity because the microgametophyte and megagametophyte are derived from different plants.Because cross-pollination allows for more genetic diversity, plants have developed many ways to avoid self-pollination. In some species, the pollen and the ovary mature at different times. These flowers make self-pollination nearly impossible. By the time pollen matures and has been shed, the stigma of this flower is mature and can only be pollinated by pollen from another flower. Some flowers have developed physical features that prevent self-pollination. The primrose is one such flower. Primroses have evolved two flower types with differences in anther and stigma length: the pin-eyed flower has anthers positioned at the pollen tube’s halfway point, and the thrum-eyed flower’s stigma is likewise located at the halfway point. Insects easily cross-pollinate while seeking the nectar at the bottom of the pollen tube. This phenomenon is also known as heterostyly. Many plants, such as cucumber, have male and female flowers located on different parts of the plant, thus making self-pollination difficult. In yet other species, the male and female flowers are borne on different plants (dioecious). All of these are barriers to self-pollination; therefore, the plants depend on pollinators to transfer pollen. The majority of pollinators are biotic agents such as insects (like bees, flies, and butterflies), bats, birds, and other animals. Other plant species are pollinated by abiotic agents, such as wind and water.
+Explore this interactive website to review self-pollination and cross-pollination.Living species are designed to ensure survival of their progeny; those that fail become extinct. Genetic diversity is therefore required so that in changing environmental or stress conditions, some of the progeny can survive. Self-pollination leads to the production of plants with less genetic diversity, since genetic material from the same plant is used to form gametes, and eventually, the zygote. In contrast, cross-pollination—or out-crossing—leads to greater genetic diversity because the microgametophyte and megagametophyte are derived from different plants.Because cross-pollination allows for more genetic diversity, plants have developed many ways to avoid self-pollination. In some species, the pollen and the ovary mature at different times. These flowers make self-pollination nearly impossible. By the time pollen matures and has been shed, the stigma of this flower is mature and can only be pollinated by pollen from another flower. Some flowers have developed physical features that prevent self-pollination. The primrose is one such flower. Primroses have evolved two flower types with differences in anther and stigma length: the pin-eyed flower has anthers positioned at the pollen tube’s halfway point, and the thrum-eyed flower’s stigma is likewise located at the halfway point. Insects easily cross-pollinate while seeking the nectar at the bottom of the pollen tube. This phenomenon is also known as heterostyly. Many plants, such as cucumber, have male and female flowers located on different parts of the plant, thus making self-pollination difficult. In yet other species, the male and female flowers are borne on different plants (dioecious). All of these are barriers to self-pollination; therefore, the plants depend on pollinators to transfer pollen. The majority of pollinators are biotic agents such as insects (like bees, flies, and butterflies), bats, birds, and other animals. Other plant species are pollinated by abiotic agents, such as wind and water.Incompatibility Genes in FlowersIn recent decades, incompatibility genes—which prevent pollen from germinating or growing into the stigma of a flower—have been discovered in many angiosperm species. If plants do not have compatible genes, the pollen tube stops growing. Self-incompatibility is controlled by the S (sterility) locus. Pollen tubes have to grow through the tissue of the stigma and style before they can enter the ovule. The carpel is selective in the type of pollen it allows to grow inside. The interaction is primarily between the pollen and the stigma epidermal cells. In some plants, like cabbage, the pollen is rejected at the surface of the stigma, and the unwanted pollen does not germinate. In other plants, pollen tube germination is arrested after growing one-third the length of the style, leading to pollen tube death. Pollen tube death is due either to apoptosis (programmed cell death) or to degradation of pollen tube RNA. The degradation results from the activity of a ribonuclease encoded by the S locus. The ribonuclease is secreted from the cells of the style in the extracellular matrix, which lies alongside the growing pollen tube.
diff --git a/modules/m66611/index.cnxml b/modules/m66611/index.cnxml
index 7d116a2bb..5589eb711 100644
--- a/modules/m66611/index.cnxml
+++ b/modules/m66611/index.cnxml
@@ -93,7 +93,7 @@
An important concept in understanding how efficient diffusion is as a means of transport is the surface to volume ratio. Recall that any three-dimensional object has a surface area and volume; the ratio of these two quantities is the surface-to-volume ratio. Consider a cell shaped like a perfect sphere: it has a surface area of 4πr2, and a volume of (4/3)πr3. The surface-to-volume ratio of a sphere is 3/r; as the cell gets bigger, its surface to volume ratio decreases, making diffusion less efficient. The larger the size of the sphere, or animal, the less surface area for diffusion it possesses.The solution to producing larger organisms is for them to become multicellular. Specialization occurs in complex organisms, allowing cells to become more efficient at doing fewer tasks. For example, circulatory systems bring nutrients and remove waste, while respiratory systems provide oxygen for the cells and remove carbon dioxide from them. Other organ systems have developed further specialization of cells and tissues and efficiently control body functions. Moreover, surface-to-volume ratio applies to other areas of animal development, such as the relationship between muscle mass and cross-sectional surface area in supporting skeletons, and in the relationship between muscle mass and the generation and dissipation of heat.
-Visit this interactive site to see an entire animal (a zebrafish embryo) at the cellular and sub-cellular level. Use the zoom and navigation functions for a virtual nanoscopy exploration.
+Visit this interactive site to see an entire animal (a zebrafish embryo) at the cellular and sub-cellular level. Use the zoom and navigation functions for a virtual nanoscopy exploration.Animal Bioenergetics
diff --git a/modules/m66612/index.cnxml b/modules/m66612/index.cnxml
index bf84d14f7..c4071467a 100644
--- a/modules/m66612/index.cnxml
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@@ -257,7 +257,7 @@
The neuron has projections called dendrites that receive signals and projections called axons that send signals. Also shown are two types of glial cells: astrocytes regulate the chemical environment of the nerve cell, and oligodendrocytes insulate the axon so the electrical nerve impulse is transferred more efficiently.
-Click through the interactive review to learn more about epithelial tissues.
+Click through the interactive review to learn more about epithelial tissues.PathologistA pathologist is a medical doctor or veterinarian who has specialized in the laboratory detection of disease in animals, including humans. These professionals complete medical school education and follow it with an extensive post-graduate residency at a medical center. A pathologist may oversee clinical laboratories for the evaluation of body tissue and blood samples for the detection of disease or infection. They examine tissue specimens through a microscope to identify cancers and other diseases. Some pathologists perform autopsies to determine the cause of death and the progression of disease.
diff --git a/modules/m66616/index.cnxml b/modules/m66616/index.cnxml
index 403ad39e9..b1fd19aa8 100644
--- a/modules/m66616/index.cnxml
+++ b/modules/m66616/index.cnxml
@@ -23,10 +23,10 @@
For humans, a balanced diet includes fruits, vegetables, grains, and protein. (credit: USDA)
-The first step in ensuring that you are meeting the food requirements of your body is an awareness of the food groups and the nutrients they provide. To learn more about each food group and the recommended daily amounts, explore this interactive site by the United States Department of Agriculture.
+The first step in ensuring that you are meeting the food requirements of your body is an awareness of the food groups and the nutrients they provide. To learn more about each food group and the recommended daily amounts, explore this interactive site by the United States Department of Agriculture. Let’s Move! Campaign
-Obesity is a growing epidemic and the rate of obesity among children is rapidly rising in the United States. To combat childhood obesity and ensure that children get a healthy start in life, first lady Michelle Obama has launched the Let’s Move! campaign. The goal of this campaign is to educate parents and caregivers on providing healthy nutrition and encouraging active lifestyles to future generations. This program aims to involve the entire community, including parents, teachers, and healthcare providers to ensure that children have access to healthy foods—more fruits, vegetables, and whole grains—and consume fewer calories from processed foods. Another goal is to ensure that children get physical activity. With the increase in television viewing and stationary pursuits such as video games, sedentary lifestyles have become the norm. Learn more at https://letsmove.obamawhitehouse.archives.gov.
+Obesity is a growing epidemic and the rate of obesity among children is rapidly rising in the United States. To combat childhood obesity and ensure that children get a healthy start in life, first lady Michelle Obama has launched the Let’s Move! campaign. The goal of this campaign is to educate parents and caregivers on providing healthy nutrition and encouraging active lifestyles to future generations. This program aims to involve the entire community, including parents, teachers, and healthcare providers to ensure that children have access to healthy foods—more fruits, vegetables, and whole grains—and consume fewer calories from processed foods. Another goal is to ensure that children get physical activity. With the increase in television viewing and stationary pursuits such as video games, sedentary lifestyles have become the norm. Learn more at https://letsmove.obamawhitehouse.archives.gov.Organic PrecursorsThe organic molecules required for building cellular material and tissues must come from food. Carbohydrates or sugars are the primary source of organic carbons in the animal body. During digestion, digestible carbohydrates are ultimately broken down into glucose and used to provide energy through metabolic pathways. Complex carbohydrates, including polysaccharides, can be broken down into glucose through biochemical modification; however, humans do not produce the enzyme cellulase and lack the ability to derive glucose from the polysaccharide cellulose. In humans, these molecules provide the fiber required for moving waste through the large intestine and a healthy colon. The intestinal flora in the human gut are able to extract some nutrition from these plant fibers. The excess sugars in the body are converted into glycogen and stored in the liver and muscles for later use. Glycogen stores are used to fuel prolonged exertions, such as long-distance running, and to provide energy during food shortage. Excess glycogen can be converted to fats, which are stored in the lower layer of the skin of mammals for insulation and energy storage. Excess digestible carbohydrates are stored by mammals in order to survive famine and aid in mobility.Another important requirement is that of nitrogen. Protein catabolism provides a source of organic nitrogen. Amino acids are the building blocks of proteins and protein breakdown provides amino acids that are used for cellular function. The carbon and nitrogen derived from these become the building block for nucleotides, nucleic acids, proteins, cells, and tissues. Excess nitrogen must be excreted as it is toxic. Fats add flavor to food and promote a sense of satiety or fullness. Fatty foods are also significant sources of energy because one gram of fat contains nine calories. Fats are required in the diet to aid the absorption of fat-soluble vitamins and the production of fat-soluble hormones.
diff --git a/modules/m66617/index.cnxml b/modules/m66617/index.cnxml
index b156476a8..3fe5aab0f 100644
--- a/modules/m66617/index.cnxml
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@@ -147,7 +147,7 @@
VitaminsVitamins can be either water-soluble or lipid-soluble. Fat soluble vitamins are absorbed in the same manner as lipids. It is important to consume some amount of dietary lipid to aid the absorption of lipid-soluble vitamins. Water-soluble vitamins can be directly absorbed into the bloodstream from the intestine.
-This website has an overview of the digestion of protein, fat, and carbohydrates.
+This website has an overview of the digestion of protein, fat, and carbohydrates.
diff --git a/modules/m66618/index.cnxml b/modules/m66618/index.cnxml
index 6140919d2..b22fd184c 100644
--- a/modules/m66618/index.cnxml
+++ b/modules/m66618/index.cnxml
@@ -33,7 +33,7 @@
One of the important factors under hormonal control is the stomach acid environment. During the gastric phase, the hormone gastrin is secreted by G cells in the stomach in response to the presence of proteins. Gastrin stimulates the release of stomach acid, or hydrochloric acid (HCl) which aids in the digestion of the proteins. However, when the stomach is emptied, the acidic environment need not be maintained and a hormone called somatostatin stops the release of hydrochloric acid. This is controlled by a negative feedback mechanism.In the duodenum, digestive secretions from the liver, pancreas, and gallbladder play an important role in digesting chyme during the intestinal phase. In order to neutralize the acidic chyme, a hormone called secretin stimulates the pancreas to produce alkaline bicarbonate solution and deliver it to the duodenum. Secretin acts in tandem with another hormone called cholecystokinin (CCK). Not only does CCK stimulate the pancreas to produce the requisite pancreatic juices, it also stimulates the gallbladder to release bile into the duodenum.
-Visit this website to learn more about the endocrine system. Review the text and watch the animation of how control is implemented in the endocrine system.
+Visit this website to learn more about the endocrine system. Review the text and watch the animation of how control is implemented in the endocrine system.Another level of hormonal control occurs in response to the composition of food. Foods high in lipids take a long time to digest. A hormone called gastric inhibitory peptide is secreted by the small intestine to slow down the peristaltic movements of the intestine to allow fatty foods more time to be digested and absorbed.Understanding the hormonal control of the digestive system is an important area of ongoing research. Scientists are exploring the role of each hormone in the digestive process and developing ways to target these hormones. Advances could lead to knowledge that may help to battle the obesity epidemic.
diff --git a/modules/m66620/index.cnxml b/modules/m66620/index.cnxml
index af79f8ad8..c7bf6f682 100644
--- a/modules/m66620/index.cnxml
+++ b/modules/m66620/index.cnxml
@@ -77,7 +77,7 @@ At one time, scientists believed that people were born with all the neurons they
This micrograph shows fluorescently labeled new neurons in a rat hippocampus. Cells that are actively dividing have bromodeoxyuridine (BrdU) incorporated into their DNA and are labeled in red. Cells that express glial fibrillary acidic protein (GFAP) are labeled in green. Astrocytes, but not neurons, express GFAP. Thus, cells that are labeled both red and green are actively dividing astrocytes, whereas cells labeled red only are actively dividing neurons. (credit: modification of work by Dr. Maryam Faiz, et. al., University of Barcelona; scale-bar data from Matt Russell)
-This site contains more information about neurogenesis, including an interactive laboratory simulation and a video that explains how BrdU labels new cells.
+This site contains more information about neurogenesis, including an interactive laboratory simulation and a video that explains how BrdU labels new cells.Glia
diff --git a/modules/m66621/index.cnxml b/modules/m66621/index.cnxml
index 05471b4cc..f85929c61 100644
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+++ b/modules/m66621/index.cnxml
@@ -100,7 +100,7 @@
The action potential is conducted down the axon as the axon membrane depolarizes, then repolarizes.
-This video presents an overview of action potential.
+This video presents an overview of action potential.Myelin and the Propagation of the Action PotentialFor an action potential to communicate information to another neuron, it must travel along the axon and reach the axon terminals where it can initiate neurotransmitter release. The speed of conduction of an action potential along an axon is influenced by both the diameter of the axon and the axon’s resistance to current leak. Myelin acts as an insulator that prevents current from leaving the axon; this increases the speed of action potential conduction. In demyelinating diseases like multiple sclerosis, action potential conduction slows because current leaks from previously insulated axon areas. The nodes of Ranvier, illustrated in are gaps in the myelin sheath along the axon. These unmyelinated spaces are about one micrometer long and contain voltage-gated Na+ and K+ channels. Flow of ions through these channels, particularly the Na+ channels, regenerates the action potential over and over again along the axon. This ‘jumping’ of the action potential from one node to the next is called saltatory conduction. If nodes of Ranvier were not present along an axon, the action potential would propagate very slowly since Na+ and K+ channels would have to continuously regenerate action potentials at every point along the axon instead of at specific points. Nodes of Ranvier also save energy for the neuron since the channels only need to be present at the nodes and not along the entire axon.
@@ -191,7 +191,7 @@ Amyotrophic lateral sclerosis (ALS, also called Lou Gehrig’s Disease) is a neu
With brain-computer interface technology, neural signals from a paralyzed patient are collected, decoded, and then fed to a tool, such as a computer, a wheelchair, or a robotic arm.
-Watch this video in which a paralyzed woman uses a brain-controlled robotic arm to bring a drink to her mouth, among other images of brain-computer interface technology in action.
+Watch this video in which a paralyzed woman uses a brain-controlled robotic arm to bring a drink to her mouth, among other images of brain-computer interface technology in action.
diff --git a/modules/m66622/index.cnxml b/modules/m66622/index.cnxml
index 8c1422b6b..5f772db90 100644
--- a/modules/m66622/index.cnxml
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@@ -28,7 +28,7 @@
These illustrations show the (a) coronal and (b) sagittal sections of the human brain.
In other surgeries to treat severe epilepsy, the corpus callosum is cut instead of removing an entire hemisphere. This causes a condition called split-brain, which gives insights into unique functions of the two hemispheres. For example, when an object is presented to patients’ left visual field, they may be unable to verbally name the object (and may claim to not have seen an object at all). This is because the visual input from the left visual field crosses and enters the right hemisphere and cannot then signal to the speech center, which generally is found in the left side of the brain. Remarkably, if a split-brain patient is asked to pick up a specific object out of a group of objects with the left hand, the patient will be able to do so but will still be unable to vocally identify it.
-See this website to learn more about split-brain patients and to play a game where you can model the split-brain experiments yourself.
+See this website to learn more about split-brain patients and to play a game where you can model the split-brain experiments yourself.Each cortical hemisphere contains regions called lobes that are involved in different functions. Scientists use various techniques to determine what brain areas are involved in different functions: they examine patients who have had injuries or diseases that affect specific areas and see how those areas are related to functional deficits. They also conduct animal studies where they stimulate brain areas and see if there are any behavioral changes. They use a technique called transcranial magnetic stimulation (TMS) to temporarily deactivate specific parts of the cortex using strong magnets placed outside the head; and they use functional magnetic resonance imaging (fMRI) to look at changes in oxygenated blood flow in particular brain regions that correlate with specific behavioral tasks. These techniques, and others, have given great insight into the functions of different brain regions but have also showed that any given brain area can be involved in more than one behavior or process, and any given behavior or process generally involves neurons in multiple brain areas. That being said, each hemisphere of the mammalian cerebral cortex can be broken down into four functionally and spatially defined lobes: frontal, parietal, temporal, and occipital. illustrates these four lobes of the human cerebral cortex.
diff --git a/modules/m66624/index.cnxml b/modules/m66624/index.cnxml
index cb8729ca1..5c06a4b9f 100644
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@@ -22,7 +22,7 @@
Alzheimer’s disease was named for Alois Alzheimer, a German psychiatrist who published a report in 1911 about a woman who showed severe dementia symptoms. Along with his colleagues, he examined the woman’s brain following her death and reported the presence of abnormal clumps, which are now called amyloid plaques, along with tangled brain fibers called neurofibrillary tangles. Amyloid plaques, neurofibrillary tangles, and an overall shrinking of brain volume are commonly seen in the brains of Alzheimer’s patients. Loss of neurons in the hippocampus is especially severe in advanced Alzheimer’s patients. compares a normal brain to the brain of an Alzheimer’s patient. Many research groups are examining the causes of these hallmarks of the disease.One form of the disease is usually caused by mutations in one of three known genes. This rare form of early onset Alzheimer’s disease affects fewer than five percent of patients with the disease and causes dementia beginning between the ages of 30 and 60. The more prevalent, late-onset form of the disease likely also has a genetic component. One particular gene, apolipoprotein E (APOE) has a variant (E4) that increases a carrier’s likelihood of getting the disease. Many other genes have been identified that might be involved in the pathology.
-Visit this website for video links discussing genetics and Alzheimer’s disease.
+Visit this website for video links discussing genetics and Alzheimer’s disease.Unfortunately, there is no cure for Alzheimer’s disease. Current treatments focus on managing the symptoms of the disease. Because decrease in the activity of cholinergic neurons (neurons that use the neurotransmitter acetylcholine) is common in Alzheimer’s disease, several drugs used to treat the disease work by increasing acetylcholine neurotransmission, often by inhibiting the enzyme that breaks down acetylcholine in the synaptic cleft. Other clinical interventions focus on behavioral therapies like psychotherapy, sensory therapy, and cognitive exercises. Since Alzheimer’s disease appears to hijack the normal aging process, research into prevention is prevalent. Smoking, obesity, and cardiovascular problems may be risk factors for the disease, so treatments for those may also help to prevent Alzheimer’s disease. Some studies have shown that people who remain intellectually active by playing games, reading, playing musical instruments, and being socially active in later life have a reduced risk of developing the disease.
@@ -49,7 +49,7 @@
AutismAutism spectrum disorder (ASD) is a neurodevelopmental disorder. Its severity differs from person to person. Estimates for the prevalence of the disorder have changed rapidly in the past few decades. Current estimates suggest that one in 88 children will develop the disorder. ASD is four times more prevalent in males than females.
-This video discusses possible reasons why there has been a recent increase in the number of people diagnosed with autism.
+This video discusses possible reasons why there has been a recent increase in the number of people diagnosed with autism.A characteristic symptom of ASD is impaired social skills. Children with autism may have difficulty making and maintaining eye contact and reading social cues. They also may have problems feeling empathy for others. Other symptoms of ASD include repetitive motor behaviors (such as rocking back and forth), preoccupation with specific subjects, strict adherence to certain rituals, and unusual language use. Up to 30 percent of patients with ASD develop epilepsy, and patients with some forms of the disorder (like Fragile X) also have intellectual disability. Because it is a spectrum disorder, other ASD patients are very functional and have good-to-excellent language skills. Many of these patients do not feel that they suffer from a disorder and instead think that their brains just process information differently.Except for some well-characterized, clearly genetic forms of autism (like Fragile X and Rett’s Syndrome), the causes of ASD are largely unknown. Variants of several genes correlate with the presence of ASD, but for any given patient, many different mutations in different genes may be required for the disease to develop. At a general level, ASD is thought to be a disease of “incorrect” wiring. Accordingly, brains of some ASD patients lack the same level of synaptic pruning that occurs in non-affected people. In the 1990s, a research paper linked autism to a common vaccine given to children. This paper was retracted when it was discovered that the author falsified data, and follow-up studies showed no connection between vaccines and autism.
@@ -71,7 +71,7 @@ Neurologists are physicians who specialize in disorders of the nervous system. T
Neurologists have other tools besides a physical exam they can use to diagnose particular problems in the nervous system. If the patient has had a seizure, for example, the neurologist can use electroencephalography (EEG), which involves taping electrodes to the scalp to record brain activity, to try to determine which brain regions are involved in the seizure. In suspected stroke patients, a neurologist can use a computerized tomography (CT) scan, which is a type of X-ray, to look for bleeding in the brain or a possible brain tumor. To treat patients with neurological problems, neurologists can prescribe medications or refer the patient to a neurosurgeon for surgery.
-This website allows you to see the different tests a neurologist might use to see what regions of the nervous system may be damaged in a patient.
+This website allows you to see the different tests a neurologist might use to see what regions of the nervous system may be damaged in a patient.Mental IllnessesMental illnesses are nervous system disorders that result in problems with thinking, mood, or relating with other people. These disorders are severe enough to affect a person’s quality of life and often make it difficult for people to perform the routine tasks of daily living. Debilitating mental disorders affect approximately 12.5 million Americans (about 1 in 17 people) at an annual cost of more than $300 billion. There are several types of mental disorders including schizophrenia, major depression, bipolar disorder, anxiety disorders and phobias, post-traumatic stress disorders, and obsessive-compulsive disorder (OCD), among others. The American Psychiatric Association publishes the Diagnostic and Statistical Manual of Mental Disorders (or DSM), which describes the symptoms required for a patient to be diagnosed with a particular mental disorder. Each newly released version of the DSM contains different symptoms and classifications as scientists learn more about these disorders, their causes, and how they relate to each other. A more detailed discussion of two mental illnesses—schizophrenia and major depression—is given below.
diff --git a/modules/m66629/index.cnxml b/modules/m66629/index.cnxml
index 7c5794708..b64097358 100644
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@@ -122,7 +122,7 @@
The sympathetic nervous system regulates the stress response via the hypothalamus. Stressful stimuli cause the hypothalamus to signal the adrenal medulla (which mediates short-term stress responses) via nerve impulses, and the adrenal cortex, which mediates long-term stress responses, via the hormone adrenocorticotropic hormone (ACTH), which is produced by the anterior pituitary.Short-term Stress ResponseWhen presented with a stressful situation, the body responds by calling for the release of hormones that provide a burst of energy. The hormones epinephrine (also known as adrenaline) and norepinephrine (also known as noradrenaline) are released by the adrenal medulla. How do these hormones provide a burst of energy? Epinephrine and norepinephrine increase blood glucose levels by stimulating the liver and skeletal muscles to break down glycogen and by stimulating glucose release by liver cells. Additionally, these hormones increase oxygen availability to cells by increasing the heart rate and dilating the bronchioles. The hormones also prioritize body function by increasing blood supply to essential organs such as the heart, brain, and skeletal muscles, while restricting blood flow to organs not in immediate need, such as the skin, digestive system, and kidneys. Epinephrine and norepinephrine are collectively called catecholamines.
-Watch this Discovery Channel animation describing the flight-or-flight response.
+Watch this Discovery Channel animation describing the flight-or-flight response.Long-term Stress ResponseLong-term stress response differs from short-term stress response. The body cannot sustain the bursts of energy mediated by epinephrine and norepinephrine for long times. Instead, other hormones come into play. In a long-term stress response, the hypothalamus triggers the release of ACTH from the anterior pituitary gland. The adrenal cortex is stimulated by ACTH to release steroid hormones called corticosteroids. Corticosteroids turn on transcription of certain genes in the nuclei of target cells. They change enzyme concentrations in the cytoplasm and affect cellular metabolism. There are two main corticosteroids: glucocorticoids such as cortisol, and mineralocorticoids such as aldosterone. These hormones target the breakdown of fat into fatty acids in the adipose tissue. The fatty acids are released into the bloodstream for other tissues to use for ATP production. The glucocorticoids primarily affect glucose metabolism by stimulating glucose synthesis. Glucocorticoids also have anti-inflammatory properties through inhibition of the immune system. For example, cortisone is used as an anti-inflammatory medication; however, it cannot be used long term as it increases susceptibility to disease due to its immune-suppressing effects.
diff --git a/modules/m66638/index.cnxml b/modules/m66638/index.cnxml
index da0b299a9..b518be86b 100644
--- a/modules/m66638/index.cnxml
+++ b/modules/m66638/index.cnxml
@@ -68,7 +68,7 @@
Trabeculae in spongy bone are arranged such that one side of the bone bears tension and the other withstands compression.
-View micrographs of musculoskeletal tissues as you review the anatomy.
+View micrographs of musculoskeletal tissues as you review the anatomy.Cell Types in Bones
diff --git a/modules/m66643/index.cnxml b/modules/m66643/index.cnxml
index e96c55ea1..ecad21ff5 100644
--- a/modules/m66643/index.cnxml
+++ b/modules/m66643/index.cnxml
@@ -77,7 +77,7 @@
-View this animation of the cross-bridge muscle contraction.
+View this animation of the cross-bridge muscle contraction.
diff --git a/modules/m66651/index.cnxml b/modules/m66651/index.cnxml
index fa196bd34..fa842e581 100644
--- a/modules/m66651/index.cnxml
+++ b/modules/m66651/index.cnxml
@@ -61,7 +61,7 @@ Red blood cells are coated in antigens made of glycolipids and glycoproteins. Th
Human red blood cells may have either type A or B glycoproteins on their surface, both glycoproteins combined (AB), or neither (O). The glycoproteins serve as antigens and can elicit an immune response in a person who receives a transfusion containing unfamiliar antigens. Type O blood, which has no A or B antigens, does not elicit an immune response when injected into a person of any blood type. Thus, O is considered the universal donor. Persons with type AB blood can accept blood from any blood type, and type AB is considered the universal acceptor.
-Play a blood typing game on the Nobel Prize website to solidify your understanding of blood types.
+Play a blood typing game on the Nobel Prize website to solidify your understanding of blood types.Section SummarySpecific components of the blood include red blood cells, white blood cells, platelets, and the plasma, which contains coagulation factors and serum. Blood is important for regulation of the body’s pH, temperature, osmotic pressure, the circulation of nutrients and removal of waste, the distribution of hormones from endocrine glands, and the elimination of excess heat; it also contains components for blood clotting. Red blood cells are specialized cells that contain hemoglobin and circulate through the body delivering oxygen to cells. White blood cells are involved in the immune response to identify and target invading bacteria, viruses, and other foreign organisms; they also recycle waste components, such as old red blood cells. Platelets and blood clotting factors cause the change of the soluble protein fibrinogen to the insoluble protein fibrin at a wound site forming a plug. Plasma consists of 90 percent water along with various substances, such as coagulation factors and antibodies. The serum is the plasma component of the blood without the coagulation factors.
diff --git a/modules/m66653/index.cnxml b/modules/m66653/index.cnxml
index 2240df0ac..e6b57c15f 100644
--- a/modules/m66653/index.cnxml
+++ b/modules/m66653/index.cnxml
@@ -58,7 +58,7 @@
The beating of the heart is regulated by an electrical impulse that causes the characteristic reading of an ECG. The signal is initiated at the sinoatrial valve. The signal then (a) spreads to the atria, causing them to contract. The signal is (b) delayed at the atrioventricular node before it is passed on to the (c) heart apex. The delay allows the atria to relax before the (d) ventricles contract. The final part of the ECG cycle prepares the heart for the next beat.
-Visit this site to see the heart’s “pacemaker” in action.
+Visit this site to see the heart’s “pacemaker” in action.Arteries, Veins, and Capillaries
diff --git a/modules/m66658/index.cnxml b/modules/m66658/index.cnxml
index 402afa1ff..e9bd1c39e 100644
--- a/modules/m66658/index.cnxml
+++ b/modules/m66658/index.cnxml
@@ -63,7 +63,7 @@
Capillary Network within the NephronThe capillary network that originates from the renal arteries supplies the nephron with blood that needs to be filtered. The branch that enters the glomerulus is called the afferent arteriole. The branch that exits the glomerulus is called the efferent arteriole. Within the glomerulus, the network of capillaries is called the glomerular capillary bed. Once the efferent arteriole exits the glomerulus, it forms the peritubular capillary network, which surrounds and interacts with parts of the renal tubule. In cortical nephrons, the peritubular capillary network surrounds the PCT and DCT. In juxtamedullary nephrons, the peritubular capillary network forms a network around the loop of Henle and is called the vasa recta.
-Go to this website to see another coronal section of the kidney and to explore an animation of the workings of nephrons.
+Go to this website to see another coronal section of the kidney and to explore an animation of the workings of nephrons.Kidney Function and Physiology
@@ -75,7 +75,7 @@
Glomerular FiltrationGlomerular filtration filters out most of the solutes due to high blood pressure and specialized membranes in the afferent arteriole. The blood pressure in the glomerulus is maintained independent of factors that affect systemic blood pressure. The “leaky” connections between the endothelial cells of the glomerular capillary network allow solutes to pass through easily. All solutes in the glomerular capillaries, except for macromolecules like proteins, pass through by passive diffusion. There is no energy requirement at this stage of the filtration process. Glomerular filtration rate (GFR) is the volume of glomerular filtrate formed per minute by the kidneys. GFR is regulated by multiple mechanisms and is an important indicator of kidney function.
-To learn more about the vascular system of kidneys, click through this review and the steps of blood flow.
+To learn more about the vascular system of kidneys, click through this review and the steps of blood flow.Tubular Reabsorption and SecretionTubular reabsorption occurs in the PCT part of the renal tubule. Almost all nutrients are reabsorbed, and this occurs either by passive or active transport. Reabsorption of water and some key electrolytes are regulated and can be influenced by hormones. Sodium (Na+) is the most abundant ion and most of it is reabsorbed by active transport and then transported to the peritubular capillaries. Because Na+ is actively transported out of the tubule, water follows it to even out the osmotic pressure. Water is also independently reabsorbed into the peritubular capillaries due to the presence of aquaporins, or water channels, in the PCT. This occurs due to the low blood pressure and high osmotic pressure in the peritubular capillaries. However, every solute has a transport maximum and the excess is not reabsorbed.In the loop of Henle, the permeability of the membrane changes. The descending limb is permeable to water, not solutes; the opposite is true for the ascending limb. Additionally, the loop of Henle invades the renal medulla, which is naturally high in salt concentration and tends to absorb water from the renal tubule and concentrate the filtrate. The osmotic gradient increases as it moves deeper into the medulla. Because two sides of the loop of Henle perform opposing functions, as illustrated in , it acts as a countercurrent multiplier. The vasa recta around it acts as the countercurrent exchanger.
diff --git a/modules/m66663/index.cnxml b/modules/m66663/index.cnxml
index fd6875fcf..40d669475 100644
--- a/modules/m66663/index.cnxml
+++ b/modules/m66663/index.cnxml
@@ -48,7 +48,7 @@
In response to a cut, mast cells secrete histamines that cause nearby capillaries to dilate. Neutrophils and monocytes leave the capillaries. Monocytes mature into macrophages. Neutrophils, dendritic cells, and macrophages release chemicals to stimulate the inflammatory response. Neutrophils and macrophages also consume invading bacteria by phagocytosis.
Cytokines also send feedback to cells of the nervous system to bring about the overall symptoms of feeling sick, which include lethargy, muscle pain, and nausea. These effects may have evolved because the symptoms encourage the individual to rest and prevent the spreading of the infection to others. Cytokines also increase the core body temperature, causing a fever, which causes the liver to withhold iron from the blood. Without iron, certain pathogens, such as some bacteria, are unable to replicate; this is called nutritional immunity.
-Watch this 23-second stop-motion video showing a neutrophil that searches for and engulfs fungus spores during an elapsed time of about 79 minutes.
+Watch this 23-second stop-motion video showing a neutrophil that searches for and engulfs fungus spores during an elapsed time of about 79 minutes.
diff --git a/modules/m66664/index.cnxml b/modules/m66664/index.cnxml
index 1c39fe638..88d81bf8e 100644
--- a/modules/m66664/index.cnxml
+++ b/modules/m66664/index.cnxml
@@ -23,7 +23,7 @@
An APC, such as a macrophage, engulfs and digests a foreign bacterium. An antigen from the bacterium is presented on the cell surface in conjunction with an MHC II molecule. Lymphocytes of the adaptive immune response interact with antigen-embedded MHC II molecules to mature into functional immune cells.
-This animation from Rockefeller University shows how dendritic cells act as sentinels in the body's immune system.
+This animation from Rockefeller University shows how dendritic cells act as sentinels in the body's immune system.T and B Lymphocytes
diff --git a/modules/m66673/index.cnxml b/modules/m66673/index.cnxml
index 8218b44a0..e4e8c3199 100644
--- a/modules/m66673/index.cnxml
+++ b/modules/m66673/index.cnxml
@@ -191,7 +191,7 @@
During spermatogenesis, four sperm result from each primary spermatocyte.
Spermatogenesis, illustrated in , occurs in the wall of the seminiferous tubules (), with stem cells at the periphery of the tube and the spermatozoa at the lumen of the tube. Immediately under the capsule of the tubule are diploid, undifferentiated cells. These stem cells, called spermatogonia (singular: spermatagonium), go through mitosis with one offspring going on to differentiate into a sperm cell and the other giving rise to the next generation of sperm.Meiosis starts with a cell called a primary spermatocyte. At the end of the first meiotic division, a haploid cell is produced called a secondary spermatocyte. This cell is haploid and must go through another meiotic cell division. The cell produced at the end of meiosis is called a spermatid and when it reaches the lumen of the tubule and grows a flagellum, it is called a sperm cell. Four sperm result from each primary spermatocyte that goes through meiosis.Stem cells are deposited during gestation and are present at birth through the beginning of adolescence, but in an inactive state. During adolescence, gonadotropic hormones from the anterior pituitary cause the activation of these cells and the production of viable sperm. This continues into old age.
-Visit this site to see the process of spermatogenesis.
+Visit this site to see the process of spermatogenesis.Oogenesis
diff --git a/modules/m66677/index.cnxml b/modules/m66677/index.cnxml
index 7aa20f2b6..a617ea974 100644
--- a/modules/m66677/index.cnxml
+++ b/modules/m66677/index.cnxml
@@ -34,7 +34,7 @@
There is rapid fetal growth during the third trimester. (credit: modification of work by Gray’s Anatomy)
-Visit this site to see the stages of human fetal development.
+Visit this site to see the stages of human fetal development.Labor and Birth
diff --git a/modules/m66678/index.cnxml b/modules/m66678/index.cnxml
index 9795edf3f..e3d9fdf0c 100644
--- a/modules/m66678/index.cnxml
+++ b/modules/m66678/index.cnxml
@@ -33,7 +33,7 @@
The rearrangement of the cells in the mammalian blastula to two layers—the inner cell mass and the trophoblast—results in the formation of the blastocyst.
-Visit the Virtual Human Embryo project at the Endowment for Human Development site to step through an interactive that shows the stages of embryo development, including micrographs and rotating 3-D images.
+Visit the Virtual Human Embryo project at the Endowment for Human Development site to step through an interactive that shows the stages of embryo development, including micrographs and rotating 3-D images.Gastrulation
diff --git a/modules/m66688/index.cnxml b/modules/m66688/index.cnxml
index ac3f6ad8d..9c6b9e484 100644
--- a/modules/m66688/index.cnxml
+++ b/modules/m66688/index.cnxml
@@ -33,7 +33,7 @@
The (a) Chinook salmon mates once and dies. The (b) pronghorn antelope mates during specific times of the year during its reproductive life. Primates, such as humans and (c) chimpanzees, may mate on any day, independent of ovulation. (credit a: modification of work by Roger Tabor, USFWS; credit b: modification of work by Mark Gocke, USDA; credit c: modification of work by “Shiny Things”/Flickr)
-Play this interactive PBS evolution-based mating game to learn more about reproductive strategies.
+Play this interactive PBS evolution-based mating game to learn more about reproductive strategies.Energy Budgets, Reproductive Costs, and Sexual Selection in Drosophila
diff --git a/modules/m66696/index.cnxml b/modules/m66696/index.cnxml
index ab733f287..aaf331265 100644
--- a/modules/m66696/index.cnxml
+++ b/modules/m66696/index.cnxml
@@ -26,7 +26,7 @@
The time between the addition of each billion human beings to Earth decreases over time. (credit: modification of work by Ryan T. Cragun)
-Click through this video of how human populations have changed over time.
+Click through this video of how human populations have changed over time.Overcoming Density-Dependent RegulationHumans are unique in their ability to alter their environment with the conscious purpose of increasing carrying capacity. This ability is a major factor responsible for human population growth and a way of overcoming density-dependent growth regulation. Much of this ability is related to human intelligence, society, and communication. Humans can construct shelter to protect them from the elements and have developed agriculture and domesticated animals to increase their food supplies. In addition, humans use language to communicate this technology to new generations, allowing them to improve upon previous accomplishments.
@@ -57,7 +57,7 @@
Many dire predictions have been made about the world’s population leading to a major crisis called the “population explosion.” In the 1968 book The Population Bomb, biologist Dr. Paul R. Ehrlich wrote, “The battle to feed all of humanity is over. In the 1970s hundreds of millions of people will starve to death in spite of any crash programs embarked upon now. At this late date nothing can prevent a substantial increase in the world death rate.”Paul R. Erlich, prologue to The Population Bomb, (1968; repr., New York: Ballantine, 1970). While many experts view this statement as incorrect based on evidence, the laws of exponential population growth are still in effect, and unchecked human population growth cannot continue indefinitely.Several nations have instituted policies aimed at influencing population. Efforts to control population growth led to the one-child policy in China, which is now being phased out. India also implements national and regional policies to encourage family planning. On the other hand, Japan, Spain, Russia, Iran, and other countries have made efforts to increase population growth after birth rates dipped. Such policies are controversial, and the human population continues to grow. At some point the food supply may run out, but the outcomes are difficult to predict. The United Nations estimates that future world population growth may vary from 6 billion (a decrease) to 16 billion people by the year 2100.Another result of population growth is the endangerment of the natural environment. Many countries have attempted to reduce the human impact on climate change by reducing their emission of the greenhouse gas carbon dioxide. However, these treaties have not been ratified by every country. The role of human activity in causing climate change has become a hotly debated socio-political issue in some countries, including the United States. Thus, we enter the future with considerable uncertainty about our ability to curb human population growth and protect our environment.
-Visit this website and select “Launch movie” for an animation discussing the global impacts of human population growth.
+Visit this website and select “Launch movie” for an animation discussing the global impacts of human population growth.
diff --git a/modules/m66698/index.cnxml b/modules/m66698/index.cnxml
index 862a60134..e501137b7 100644
--- a/modules/m66698/index.cnxml
+++ b/modules/m66698/index.cnxml
@@ -53,7 +53,7 @@
Several unpleasant-tasting Heliconius butterfly species share a similar color pattern with better-tasting varieties, an example of Müllerian mimicry. (credit: Joron M, Papa R, Beltrán M, Chamberlain N, Mavárez J, et al.)
-Go to this website to view stunning examples of mimicry.
+Go to this website to view stunning examples of mimicry.
diff --git a/modules/m66699/index.cnxml b/modules/m66699/index.cnxml
index a0a784f95..178956e1c 100644
--- a/modules/m66699/index.cnxml
+++ b/modules/m66699/index.cnxml
@@ -88,7 +88,7 @@
Not all animals reproduce sexually, but many that do have the same challenge: they need to find a suitable mate and often have to compete with other individuals to obtain one. Significant energy is spent in the process of locating, attracting, and mating with the sex partner. Two types of selection occur during this process: intersexual selection, where individuals of one sex choose mates of the other sex, and intrasexual selection, the competition for mates between species members of the same sex. Intersexual selection is often complex because choosing a mate may be based on a variety of visual, aural, tactile, and chemical cues. An example of intersexual selection is when female peacocks choose to mate with the male with the brightest plumage. This type of selection often leads to traits in the chosen sex that do not enhance survival, but are those traits most attractive to the opposite sex (often at the expense of survival). Intrasexual selection involves mating displays and aggressive mating rituals such as rams butting heads—the winner of these battles is the one that is able to mate. Many of these rituals use up considerable energy but result in the selection of the healthiest, strongest, and/or most dominant individuals for mating.Three general mating systems, all involving innate as opposed to learned behaviors, are seen in animal populations: monogamous, polygynous, and polyandrous.
-Visit this website for informative videos on sexual selection.
+Visit this website for informative videos on sexual selection.In monogamous systems, one male and one female are paired for at least one breeding season. In some animals, such as the gray wolf, these associations can last much longer, even a lifetime. Several theories may explain this type of mating system. The “mate-guarding hypothesis” states that males stay with the female to prevent other males from mating with her. This behavior is advantageous in such situations where mates are scarce and difficult to find. Another explanation is the “male-assistance hypothesis,” where males that help guard and rear their young will have more and healthier offspring. Monogamy is observed in many bird populations where, in addition to the parental care from the female, the male is also a major provider of parental care for the chicks. A third explanation for the evolutionary advantages of monogamy is the “female-enforcement hypothesis.” In this scenario, the female ensures that the male does not have other offspring that might compete with her own, so she actively interferes with the male’s signaling to attract other mates.Polygynous mating refers to one male mating with multiple females. In these situations, the female must be responsible for most of the parental care as the single male is not capable of providing care to that many offspring. In resourced-based polygyny, males compete for territories with the best resources, and then mate with females that enter the territory, drawn to its resource richness. The female benefits by mating with a dominant, genetically fit male; however, it is at the cost of having no male help in caring for the offspring. An example is seen in the yellow-rumped honeyguide, a bird whose males defend beehives because the females feed on their wax. As the females approach, the male defending the nest will mate with them. Harem mating structures are a type of polygynous system where certain males dominate mating while controlling a territory with resources. Harem mating occurs in elephant seals, where the alpha male dominates the mating within the group. A third type of polygyny is a lek system. Here there is a communal courting area where several males perform elaborate displays for females, and the females choose their mate from this group. This behavior is observed in several bird species including the sage grouse and the prairie chicken.
diff --git a/modules/m66701/index.cnxml b/modules/m66701/index.cnxml
index 9fff18587..9d9ecba6d 100644
--- a/modules/m66701/index.cnxml
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@@ -54,7 +54,7 @@
This food web shows the interactions between organisms across trophic levels in the Lake Ontario ecosystem. Primary producers are outlined in green, primary consumers in orange, secondary consumers in blue, and tertiary (apex) consumers in purple. Arrows point from an organism that is consumed to the organism that consumes it. Notice how some lines point to more than one trophic level. For example, the opossum shrimp eats both primary producers and primary consumers. (credit: NOAA, GLERL)
A comparison of the two types of structural ecosystem models shows strength in both. Food chains are more flexible for analytical modeling, are easier to follow, and are easier to experiment with, whereas food web models more accurately represent ecosystem structure and dynamics, and data can be directly used as input for simulation modeling.
-Head to this online interactive simulator to investigate food web function. In the Interactive Labs box, under Food Web, click Step 1. Read the instructions first, and then click Step 2 for additional instructions. When you are ready to create a simulation, in the upper-right corner of the Interactive Labs box, click OPEN SIMULATOR.
+Head to this online interactive simulator to investigate food web function. In the Interactive Labs box, under Food Web, click Step 1. Read the instructions first, and then click Step 2 for additional instructions. When you are ready to create a simulation, in the upper-right corner of the Interactive Labs box, click OPEN SIMULATOR.Two general types of food webs are often shown interacting within a single ecosystem. A grazing food web (such as the Lake Ontario food web in ) has plants or other photosynthetic organisms at its base, followed by herbivores and various carnivores. A detrital food web consists of a base of organisms that feed on decaying organic matter (dead organisms), called decomposers or detritivores. These organisms are usually bacteria or fungi that recycle organic material back into the biotic part of the ecosystem as they themselves are consumed by other organisms. As all ecosystems require a method to recycle material from dead organisms, most grazing food webs have an associated detrital food web. For example, in a meadow ecosystem, plants may support a grazing food web of different organisms, primary and other levels of consumers, while at the same time supporting a detrital food web of bacteria, fungi, and detrivorous invertebrates feeding off dead plants and animals.Three-spined Stickleback
@@ -98,7 +98,7 @@
Analytical models often use simple, linear components of ecosystems, such as food chains, and are known to be complex mathematically; therefore, they require a significant amount of mathematical knowledge and expertise. Although analytical models have great potential, their simplification of complex ecosystems is thought to limit their accuracy. Simulation models that use computer programs are better able to deal with the complexities of ecosystem structure.A recent development in simulation modeling uses supercomputers to create and run individual-based simulations, which accounts for the behavior of individual organisms and their effects on the ecosystem as a whole. These simulations are considered to be the most accurate and predictive of the complex responses of ecosystems to disturbances.
-Visit The Darwin Project to view a variety of ecosystem models, including simulations that model predator-prey relationships to learn more.
+Visit The Darwin Project to view a variety of ecosystem models, including simulations that model predator-prey relationships to learn more.
diff --git a/modules/m66705/index.cnxml b/modules/m66705/index.cnxml
index 9960f2a32..ddf6d6466 100644
--- a/modules/m66705/index.cnxml
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@@ -15,7 +15,7 @@
Water contains hydrogen and oxygen, which is essential to all living processes. The hydrosphere is the area of the Earth where water movement and storage occurs. On or beneath the surface, water occurs in liquid or solid form in rivers, lakes, oceans, groundwater, polar ice caps, and glaciers. And it occurs as water vapor in the atmosphere. Carbon is found in all organic macromolecules and is an important constituent of fossil fuels. Nitrogen is a major component of our nucleic acids and proteins and is critical to human agriculture. Phosphorus, a major component of nucleic acid (along with nitrogen), is one of the main ingredients in artificial fertilizers used in agriculture and their associated environmental impacts on our surface water. Sulfur is critical to the 3-D folding of proteins, such as in disulfide binding.The cycling of these elements is interconnected. For example, the movement of water is critical for the leaching of nitrogen and phosphate into rivers, lakes, and oceans. Furthermore, the ocean itself is a major reservoir for carbon. Thus, mineral nutrients are cycled, either rapidly or slowly, through the entire biosphere, from one living organism to another, and between the biotic and abiotic world.
-Head to this website to learn more about biogeochemical cycles.
+Head to this website to learn more about biogeochemical cycles.The Water (Hydrologic) Cycle
@@ -40,7 +40,7 @@
The water cycle is driven by the sun’s energy as it warms the oceans and other surface waters. This leads to the evaporation (water to water vapor) of liquid surface water and the sublimation (ice to water vapor) of frozen water, which deposits large amounts of water vapor into the atmosphere. Over time, this water vapor condenses into clouds as liquid or frozen droplets and is eventually followed by precipitation (rain or snow), which returns water to the Earth’s surface. Rain eventually permeates into the ground, where it may evaporate again if it is near the surface, flow beneath the surface, or be stored for long periods. More easily observed is surface runoff: the flow of fresh water either from rain or melting ice. Runoff can then make its way through streams and lakes to the oceans or flow directly to the oceans themselves.
-Head to this website to learn more about the world’s fresh water supply.
+Head to this website to learn more about the world’s fresh water supply.Rain and surface runoff are major ways in which minerals, including carbon, nitrogen, phosphorus, and sulfur, are cycled from land to water. The environmental effects of runoff will be discussed later as these cycles are described.
@@ -59,7 +59,7 @@
Carbon dioxide gas exists in the atmosphere and is dissolved in water. Photosynthesis converts carbon dioxide gas to organic carbon, and respiration cycles the organic carbon back into carbon dioxide gas. Long-term storage of organic carbon occurs when matter from living organisms is buried deep underground and becomes fossilized. Volcanic activity and, more recently, human emissions, bring this stored carbon back into the carbon cycle. (credit: modification of work by John M. Evans and Howard Perlman, USGS)
-Click this link to read information about the United States Carbon Cycle Science Program.
+Click this link to read information about the United States Carbon Cycle Science Program.The Biological Carbon Cycle
@@ -159,7 +159,7 @@
Sulfur enters the ocean via runoff from land, from atmospheric fallout, and from underwater geothermal vents. Some ecosystems () rely on chemoautotrophs using sulfur as a biological energy source. This sulfur then supports marine ecosystems in the form of sulfates.Human activities have played a major role in altering the balance of the global sulfur cycle. The burning of large quantities of fossil fuels, especially from coal, releases larger amounts of hydrogen sulfide gas into the atmosphere. Acid rain is caused by rainwater falling to the ground through this sulfur dioxide gas, turning it into weak sulfuric acid. Acid rain damages the natural environment by lowering the pH of lakes, which kills many of the resident fauna; it also affects the man-made environment through the chemical degradation of buildings. For example, many marble monuments, such as the Lincoln Memorial in Washington, DC, have suffered significant damage from acid rain over the years.
-Click this link to learn more about global climate change.
+Click this link to learn more about global climate change.
diff --git a/modules/m66707/index.cnxml b/modules/m66707/index.cnxml
index 2065e1833..870151ae4 100644
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@@ -47,7 +47,7 @@
Mora et al. 2011Mora Camilo et al., “How Many Species Are There on Earth and in the Ocean?” PLoS Biology (2011), doi:10.1371/journal.pbio.1001127.
-Chapman 2009Arthur D. Chapman, Numbers of Living Species in Australia and the World, 2nd ed. (Canberra, AU: Australian Biological Resources Study, 2009). https://www.environment.gov.au/system/files/pages/2ee3f4a1-f130-465b-9c7a-79373680a067/files/nlsaw-2nd-complete.pdf/.
+Chapman 2009Arthur D. Chapman, Numbers of Living Species in Australia and the World, 2nd ed. (Canberra, AU: Australian Biological Resources Study, 2009). https://www.environment.gov.au/system/files/pages/2ee3f4a1-f130-465b-9c7a-79373680a067/files/nlsaw-2nd-complete.pdf/.Groombridge & Jenkins 2002Brian Groombridge and Martin D. Jenkins. World Atlas of Biodiversity: Earth’s Living Resources in the 21st Century. Berkeley: University of California Press, 2002.
@@ -127,7 +127,7 @@
-
There are various initiatives to catalog described species in accessible ways, and the internet is facilitating that effort. Nevertheless, it has been pointed out that at the current rate of new species descriptions (which according to the State of Observed Species Report is 17,000 to 20,000 new species per year), it will take close to 500 years to finish describing life on this planet.International Institute for Species Exploration (IISE), 2011 State of Observed Species (SOS). Tempe, AZ: IISE, 2011. Accessed May, 20, 2012. http://www.esf.edu/species/. Over time, the task becomes both increasingly difficult and increasingly easier as extinction removes species from the planet.Naming and counting species may seem like an unimportant pursuit given the other needs of humanity, but determining biodiversity it is not simply an accounting of species. Describing a species is a complex process through which biologists determine an organism’s unique characteristics and whether or not that organism belongs to any other described species or genus. It allows biologists to find and recognize the species after the initial discovery, and allows them to follow up on questions about its biology. In addition, the unique characteristics of each species make it potentially valuable to humans or other species on which humans depend.
+There are various initiatives to catalog described species in accessible ways, and the internet is facilitating that effort. Nevertheless, it has been pointed out that at the current rate of new species descriptions (which according to the State of Observed Species Report is 17,000 to 20,000 new species per year), it will take close to 500 years to finish describing life on this planet.International Institute for Species Exploration (IISE), 2011 State of Observed Species (SOS). Tempe, AZ: IISE, 2011. Accessed May, 20, 2012. http://www.esf.edu/species/. Over time, the task becomes both increasingly difficult and increasingly easier as extinction removes species from the planet.Naming and counting species may seem like an unimportant pursuit given the other needs of humanity, but determining biodiversity it is not simply an accounting of species. Describing a species is a complex process through which biologists determine an organism’s unique characteristics and whether or not that organism belongs to any other described species or genus. It allows biologists to find and recognize the species after the initial discovery, and allows them to follow up on questions about its biology. In addition, the unique characteristics of each species make it potentially valuable to humans or other species on which humans depend.Patterns of Biodiversity
@@ -213,7 +213,7 @@
-Explore this interactive website about mass extinctions.
+Explore this interactive website about mass extinctions.
diff --git a/modules/m66708/index.cnxml b/modules/m66708/index.cnxml
index 71f49c235..1cd1eaf93 100644
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In addition to growing crops and raising animals for food, humans obtain food resources from wild populations, primarily fish populations. In fact, for approximately 1 billion people worldwide, aquatic resources provide the main source of animal protein. But since 1990, global fish production has declined, sometimes dramatically. Unfortunately, and despite considerable effort, few fisheries on the planet are managed for sustainability.Fishery extinctions rarely lead to complete extinction of the harvested species, but rather to a radical restructuring of the marine ecosystem in which a dominant species is so over-harvested that it becomes a minor player, ecologically. In addition to humans losing the food source, these alterations affect many other species in ways that are difficult or impossible to predict. The collapse of fisheries has dramatic and long-lasting effects on local populations that work in the fishery. In addition, the loss of an inexpensive protein source to populations that cannot afford to replace it will increase the cost of living and limit societies in other ways. In general, the fish taken from fisheries have shifted to smaller species as larger species are fished to extinction. The ultimate outcome could clearly be the loss of aquatic systems as food sources.
-View a brief video discussing declining fish stocks.
+View a brief video discussing declining fish stocks.
diff --git a/modules/m66709/index.cnxml b/modules/m66709/index.cnxml
index f3f46e2f5..a917ec06b 100644
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@@ -35,12 +35,12 @@
OverharvestingOverharvesting is a serious threat to many species, but particularly to aquatic (both marine and freshwater) species. Despite regulation and monitoring, there are recent examples of fishery collapse. The western Atlantic cod fishery is the among the most significant. While it was a hugely productive fishery for 400 years, the introduction of modern factory trawlers in the 1980s caused it to become unsustainable. Fisheries collapse as a result of both economic and political factors. Fisheries are managed as a shared international resource even when the fishing territory lies within an individual country’s territorial waters. Common resources are subject to an economic pressure known as the tragedy of the commons, in which essentially no fisher has a motivation to exercise restraint in harvesting a fishery when it is not owned by that fisher. Overexploitation is a common outcome. This overexploitation is exacerbated when access to the fishery is open and unregulated and when technology gives fishers the ability to overfish. In a few fisheries, the biological growth of the resource is less than the potential growth of the profits made from fishing if that time and money were invested elsewhere. In these cases—whales are an example—economic forces will always drive toward fishing the population to extinction.
-Explore a U.S. Fish & Wildlife Service interactive map of critical habitat for endangered and threatened species in the United States. To begin, select “Visit the online mapper.”
+Explore a U.S. Fish & Wildlife Service interactive map of critical habitat for endangered and threatened species in the United States. To begin, select “Visit the online mapper.”For the most part, fishery extinction is not equivalent to biological extinction—the last fish of a species is rarely fished out of the ocean. At the same time, fishery extinction is still harmful to fish species and their ecosystems. There are some instances in which true extinction is a possibility. Whales have slow-growing populations due to low reproductive rates, and therefore are at risk of complete extinction through hunting. There are some species of sharks with restricted distributions that are at risk of extinction. The groupers are another population of generally slow-growing fishes that, in the Caribbean, includes a number of species that are at risk of extinction from overfishing.Coral reefs are extremely diverse marine ecosystems that face immediate peril from several processes. Reefs are home to 1/3 of the world’s marine fish species—about 4,000 species—despite making up only 1 percent of marine habitat. Most home marine aquaria are stocked with wild-caught organisms, not cultured organisms. Although no species is known to have been driven extinct by the pet trade in marine species, there are studies showing that populations of some species have declined in response to harvesting, indicating that the harvest is not sustainable at those levels. There are concerns about the effect of the pet trade on some terrestrial species such as turtles, amphibians, birds, plants, and even the orangutan.
-View a brief video discussing the role of marine ecosystems in supporting human welfare and the decline of ocean ecosystems.
+View a brief video discussing the role of marine ecosystems in supporting human welfare and the decline of ocean ecosystems.Bush meat is the generic term used for wild animals killed for food. Hunting is practiced throughout the world, but hunting practices, particularly in equatorial Africa and parts of Asia, are believed to threaten a number of species with extinction. Traditionally, bush meat in Africa was hunted to feed families directly; however, recent commercialization of the practice now has bush meat available in grocery stores, which has increased harvest rates to the level of unsustainability. Additionally, human population growth has increased the need for protein foods that are not being met from agriculture. Species threatened by the bush meat trade are mostly mammals including many primates living in the Congo basin.
@@ -49,7 +49,7 @@
Exotic species are species that have been intentionally or unintentionally introduced into an ecosystem in which they did not evolve. For example, Kudzu (Pueraria lobata), which is native to Japan, was introduced in the United States in 1876. It was later planted for soil conservation. Problematically, it grows too well in the southeastern United States—up to a foot a day. It is now an invasive pest species and covers over 7 million acres in the southeastern United States. If an introduced species is able to survive in its new habitat, that introduction is now reflected in the observed range of the species. Human transportation of people and goods, including the intentional transport of organisms for trade, has dramatically increased the introduction of species into new ecosystems, sometimes at distances that are well beyond the capacity of the species to ever travel itself and outside the range of the species’ natural predators.Most exotic species introductions probably fail because of the low number of individuals introduced or poor adaptation to the ecosystem they enter. Some species, however, possess pre-adaptations that can make them especially successful in a new ecosystem. These exotic species often undergo dramatic population increases in their new habitat and reset the ecological conditions in the new environment, threatening the species that exist there. For this reason, exotic species are also called invasive species. Exotic species can threaten other species through competition for resources, predation, or disease. For example, the Eurasian star thistle, also called spotted knapweed, has invaded and rendered useless some of the open prairies of the western states. However, it is a great nectar-bearing flower for the production of honey and supports numerous pollinating insects, including migrating monarch butterflies in the north-central states such as Michigan.
-Explore an interactive global database of exotic or invasive species.
+Explore an interactive global database of exotic or invasive species.Lakes and islands are particularly vulnerable to extinction threats from introduced species. In Lake Victoria, as mentioned earlier, the intentional introduction of the Nile perch was largely responsible for the extinction of about 200 species of endemic cichlids. The accidental introduction of the brown tree snake via aircraft () from the Solomon Islands to Guam in 1950 has led to the extinction of three species of birds and three to five species of reptiles endemic to the island. Several other species are still threatened. The brown tree snake is adept at exploiting human transportation as a means to migrate; one was even found on an aircraft arriving in Corpus Christi, Texas. Constant vigilance on the part of airport, military, and commercial aircraft personnel is required to prevent the snake from moving from Guam to other islands in the Pacific, especially Hawaii. Islands do not make up a large area of land on the globe, but they do contain a disproportionate number of endemic species because of their isolation from mainland ancestors.
diff --git a/modules/m66710/index.cnxml b/modules/m66710/index.cnxml
index a2d4926c1..0fc778e24 100644
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@@ -63,7 +63,7 @@
Some of the limitations on preserves as conservation tools are evident from the discussion of preserve design. Political and economic pressures typically make preserves smaller, rather than larger, so setting aside areas that are large enough is difficult. If the area set aside is sufficiently large, there may not be sufficient area to create a buffer around the preserve. In this case, an area on the outer edges of the preserve inevitably becomes a riskier suboptimal habitat for the species in the preserve. Enforcement of protections is also a significant issue in countries without the resources or political will to prevent poaching and illegal resource extraction.Climate change will create inevitable problems with the location of preserves. The species within them may migrate to higher latitudes as the habitat of the preserve becomes less favorable. Scientists are planning for the effects of global warming on future preserves and striving to predict the need for new preserves to accommodate anticipated changes to habitats; however, the end effectiveness is tenuous since these efforts are prediction based.Finally, an argument can be made that conservation preserves indicate that humans are growing more separate from nature, and that humans only operate in ways that do damage to biodiversity. Creating preserves may reduce the pressure on humans outside the preserve to be sustainable and non-damaging to biodiversity. On the other hand, properly managed, high quality preserves present opportunities for humans to witness nature in a less damaging way, and preserves may present some financial benefits to local economies. Ultimately, the economic and demographic pressures on biodiversity are unlikely to be mitigated by preserves alone. In order to fully benefit from biodiversity, humans will need to alter activities that damage it.
-An interactive global data system of protected areas can be found at this website. Review data about individual protected areas by location or study statistics on protected areas by country or region.
+An interactive global data system of protected areas can be found at this website. Review data about individual protected areas by location or study statistics on protected areas by country or region.
diff --git a/modules/m66718/index.cnxml b/modules/m66718/index.cnxml
index 00e37d59f..8d3c955b2 100644
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Directional SelectionWhen the environment changes, populations will often undergo directional selection (), which selects for phenotypes at one end of the spectrum of existing variation. A classic example of this type of selection is the evolution of the peppered moth in eighteenth- and nineteenth-century England. Prior to the Industrial Revolution, the moths were predominately light in color, which allowed them to blend in with the light-colored trees and lichens in their environment. However, as soot began spewing from factories, the trees darkened, and the light-colored moths became easier for predatory birds to spot. Over time, the frequency of the moth's melanic form increased because they had a higher survival rate in habitats affected by air pollution because their darker coloration blended with the sooty trees. Similarly, the hypothetical mouse population may evolve to take on a different coloration if something were to cause the forest floor where they live to change color. The result of this type of selection is a shift in the population’s genetic variability toward the new, fit phenotype.
-In science, we sometimes believe some things are true, and then new information becomes available that changes our understanding. The peppered moth story is an example: some scientists recently have questioned the facts behind the selection toward darker moths. Read this article to learn more.
+In science, we sometimes believe some things are true, and then new information becomes available that changes our understanding. The peppered moth story is an example: some scientists recently have questioned the facts behind the selection toward darker moths. Read this article to learn more.Diversifying Selection
@@ -58,7 +58,7 @@
Sexual dimorphism in (a) peacocks and peahens, (b) Argiope appensa spiders (the female spider is the large one), and in (c) wood ducks. (credit “spiders”: modification of work by “Sanba38”/Wikimedia Commons; credit “duck”: modification of work by Kevin Cole)
We call the selection pressures on males and females to obtain matings sexual selection. It can result in developing secondary sexual characteristics that do not benefit the individual’s likelihood of survival but help to maximize its reproductive success. Sexual selection can be so strong that it selects traits that are actually detrimental to the individual’s survival. Think, once again, about the peacock’s tail. While it is beautiful and the male with the largest, most colorful tail is more likely to win the female, it is not the most practical appendage. In addition to greater visibility to predators, it makes the males slower in their attempted escapes. There is some evidence that this risk is why females like the big tails in the first place. The speculation is that large tails carry risk, and only the best males survive that risk: the bigger the tail, the more fit the male. We call this the handicap principle.The good genes hypothesis states that males develop these impressive ornaments to show off their efficient metabolism or their ability to fight disease. Females then choose males with the most impressive traits because it signals their genetic superiority, which they will then pass on to their offspring. Although one may argue that females should not be picky because it will likely reduce their number of offspring, if better males father more fit offspring, it may be beneficial. Fewer, healthier offspring may increase the chances of survival more than many, weaker offspring.
-In 1915, biologist Ronald Fisher proposed another model of sexual selection: the Fisherian runaway model, which suggests that selection of certain traits is a result of sexual preference.
+In 1915, biologist Ronald Fisher proposed another model of sexual selection: the Fisherian runaway model, which suggests that selection of certain traits is a result of sexual preference.In both the handicap principle and the good genes hypothesis, the trait is an honest signal of the males’ quality, thus giving females a way to find the fittest mates— males that will pass the best genes to their offspring.
diff --git a/modules/m66722/index.cnxml b/modules/m66722/index.cnxml
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@@ -29,12 +29,12 @@
Ecdysozoa. Animals that molt their exoskeletons, such as these (a) Madagascar hissing cockroaches, are in the clade Ecdysozoa. (b) Phoronids are in the clade Lophotrochozoa. The tentacles are part of a feeding structure called a lophophore. (credit a: modification of work by Whitney Cranshaw, Colorado State University, Bugwood.org; credit b: modification of work by NOAA)
-Explore an interactive tree of life here. Zoom in and out and click to learn more about the organisms and their evolutionary relationships.
+Explore an interactive tree of life here. Zoom in and out and click to learn more about the organisms and their evolutionary relationships.Modern Advances in Phylogenetic Understanding Come from Molecular AnalysesThe phylogenetic groupings are continually being debated and refined by evolutionary biologists. Each year, new evidence emerges that further alters the relationships described by a phylogenetic tree diagram.
-Watch the following video to learn how biologists use genetic data to determine relationships among organisms.
+Watch the following video to learn how biologists use genetic data to determine relationships among organisms.Nucleic acid and protein analyses have greatly modified and refined the modern phylogenetic animal tree. These data come from a variety of molecular sources, such as mitochondrial DNA, nuclear DNA, ribosomal RNA (rRNA), and certain cellular proteins. Many evolutionary relationships in the modern tree have only recently been determined from the molecular evidence. For example, a previously classified group of animals called lophophorates, which included brachiopods and bryozoans, were long-thought to be primitive deuterostomes. Extensive molecular analysis using rRNA data found these animals are actually protostomes, more closely related to annelids and mollusks. This discovery allowed for the distinction of the protostome clade Lophotrochozoa. Molecular data have also shed light on some differences within the lophotrochozoan group, and the placement of the Platyhelminthes is particularly problematic. Some scientists believe that the phyla Platyhelminthes and Rotifera should actually belong to their own clade of protostomes termed Platyzoa.Molecular research similar to the discoveries that brought about the distinction of the lophotrochozoan clade has also revealed a dramatic rearrangement of the relationships between mollusks, annelids, arthropods, and nematodes, and as a result, a new ecdysozoan clade was formed. Due to morphological similarities in their segmented body types, annelids and arthropods were once thought to be closely related. However, molecular evidence has revealed that arthropods are actually more closely related to nematodes, now comprising the ecdysozoan clade, and annelids are more closely related to mollusks, brachiopods, and other phyla in the lophotrochozoan clade. These two clades now make up the protostomes.Another change to former phylogenetic groupings because of modern molecular analyses includes the emergence of an entirely new phylum of worm called Acoelomorpha. These acoel flatworms were long thought to belong to the phylum Platyhelminthes because of their similar “flatworm” morphology. However, molecular analyses revealed this to be a false relationship and originally suggested that acoels represented living species of some of the earliest divergent bilaterians. More recent research into the acoelomorphs has called this hypothesis into question and suggested that the acoels are more closely related to deuterostomes. The placement of this new phylum remains disputed, but scientists agree that with sufficient molecular data, their true phylogeny will be determined.