diff --git a/src/main/resources/reference.conf b/src/main/resources/reference.conf
index 32b0f2f8..b3950a41 100644
--- a/src/main/resources/reference.conf
+++ b/src/main/resources/reference.conf
@@ -28,7 +28,7 @@ common {
     "fda"
   ]
   output-format = "parquet"
-  output = "gs://open-targets-pre-data-releases/21.08.preview/output/etl/parquet"
+  output = "gs://open-targets-pre-data-releases/21.09.1/output/etl/parquet"
   output = ${?OT_ETL_OUTPUT}
 
   metadata {
@@ -36,7 +36,7 @@ common {
     path = ${common.output}"/metadata/"
   }
 
-  input = "gs://open-targets-pre-data-releases/21.08.preview/input"
+  input = "gs://open-targets-pre-data-releases/21.09.1/input"
 
 }
 
@@ -44,7 +44,7 @@ reactome {
   inputs {
     pathways {
       format = "csv"
-      path = ${common.input}"/annotation-files/ReactomePathways-2021-06-18.txt"
+      path = ${common.input}"/annotation-files/ReactomePathways-2021-09-16.txt"
       options = [
         {k: "sep", v: "\\t"},
         {k: "header", v: "false"}
@@ -53,7 +53,7 @@ reactome {
     }
     relations {
       format = "csv"
-      path = ${common.input}"/annotation-files/ReactomePathwaysRelation-2021-06-18.txt"
+      path = ${common.input}"/annotation-files/ReactomePathwaysRelation-2021-09-16.txt"
       options = [
         {k: "sep", v: "\\t"},
         {k: "header", v: "false"}
@@ -97,7 +97,7 @@ expression {
     }
     exprhierarchy {
       format = "csv"
-      path = ${common.input}"/annotation-files/hpa/expression_hierarchy_curation-2021-08-09.tsv"
+      path = ${common.input}"/annotation-files/hpa/expression_hierarchy_curation-2021-09-15.tsv"
       options = [
         {k: "sep", v: "\\t"},
         {k: "header", v: "false"}
@@ -106,11 +106,11 @@ expression {
     }
     efomap {
       format = "json"
-      path = ${common.input}"/annotation-files/hpa/map_with_efos-2021-08-09.json"
+      path = ${common.input}"/annotation-files/hpa/map_with_efos-2021-09-15.json"
     }
     tissues {
       format = "csv"
-      path = ${common.input}"/annotation-files/hpa/normal_tissue-2021-08-09.tsv"
+      path = ${common.input}"/annotation-files/hpa/normal_tissue-2021-09-15.tsv"
       options = [
         {k: "sep", v: "\\t"},
         {k: "header", v: "true"}
@@ -156,7 +156,7 @@ interactions {
   }
   intact {
     format = "json"
-    path = ${common.input}"/annotation-files/interactions/intact-interactors-2021-06-07.json"
+    path = ${common.input}"/annotation-files/interactions/intact-interactors-2021-09-15.json"
   }
   strings {
     format = "csv"
@@ -324,12 +324,12 @@ target {
       ]
     }
     safety-adverse-event {
-      format = "json"
-      path = ${common.input}"/target-inputs/safety/ae.json"
+      format = "parquet"
+      path = ${common.input}"/target-inputs/safety/ae_safety/*.parquet"
     }
     safety-safety-risk {
-      format = "json"
-      path = ${common.input}"/target-inputs/safety/sr.json"
+      format = "parquet"
+      path = ${common.input}"/target-inputs/safety/sr_safety/*.parquet"
     }
     tep {
       format = "json"
@@ -374,7 +374,7 @@ target {
 disease {
   efo-ontology {
     format = "json"
-    path = ${common.input}"/annotation-files/ontology/efo_json/ontology-efo-v3.31.0.jsonl"
+    path = ${common.input}"/annotation-files/ontology/efo_json/ontology-efo-v3.34.0.jsonl"
   }
   hpo-ontology {
     format = "json"
@@ -386,7 +386,7 @@ disease {
   }
   hpo-phenotype {
     format = "json"
-    path = ${common.input}"/annotation-files/ontology/efo_json/hpo-phenotypes-2021-06-18.jsonl"
+    path = ${common.input}"/annotation-files/ontology/efo_json/hpo-phenotypes-2021-09-15.jsonl"
   }
   outputs = {
     diseases {
@@ -407,23 +407,23 @@ disease {
 drug {
   chembl-molecule {
     format = "json"
-    path = ${common.input}"/annotation-files/chembl/chembl_29_molecule-2021-08-20.jsonl"
+    path = ${common.input}"/annotation-files/chembl/chembl_29_molecule-2021-09-16.jsonl"
   }
   chembl-indication {
     format = "json"
-    path = ${common.input}"/annotation-files/chembl/chembl_29_drug_indication-2021-08-20.jsonl"
+    path = ${common.input}"/annotation-files/chembl/chembl_29_drug_indication-2021-09-16.jsonl"
   }
   chembl-mechanism {
     format = "json"
-    path = ${common.input}"/annotation-files/chembl/chembl_29_mechanism-2021-08-20.jsonl"
+    path = ${common.input}"/annotation-files/chembl/chembl_29_mechanism-2021-09-16.jsonl"
   }
   chembl-target {
     format = "json"
-    path = ${common.input}"/annotation-files/chembl/chembl_28_target-2021-03-02.jsonl"
+    path = ${common.input}"/annotation-files/chembl/chembl_29_target-2021-09-16.jsonl"
   }
   chembl-warning {
     format = "json"
-    path = ${common.input}"/annotation-files/chembl/chembl_29_drug_warning-2021-08-20.jsonl"
+    path = ${common.input}"/annotation-files/chembl/chembl_29_drug_warning-2021-09-16.jsonl"
   }
   disease-etl = ${disease.outputs.diseases}
   target-etl {
@@ -433,7 +433,7 @@ drug {
   evidence-etl = ${evidences.outputs.succeeded}
   drugbank-to-chembl {
     format = "csv"
-    path = ${common.input}"/annotation-files/chembl/drugbank/db.csv.gz"
+    path = ${common.input}"/annotation-files/chembl/db.csv.gz"
     options = [
       {k: "sep", v: "\\t"},
       {k: "header", v: "true"}
@@ -1002,12 +1002,12 @@ openfda {
         meddra-preferred-terms {
             format = "csv"
             // Change this to whatever location the data is sitting on
-            path = ${openfda.step-root-input-path}"/meddra/MedAscii/pt.asc"
+            path = "gs://open-targets-data-releases-private/meddra/meddra23.1/MedAscii/pt.asc"
         }
         meddra-low-level-terms {
             format = "csv"
             // Change this to whatever location the data is sitting on
-            path = ${openfda.step-root-input-path}"/meddra/MedAscii/llt.asc"
+            path = "gs://open-targets-data-releases-private/meddra/meddra23.1/MedAscii/llt.asc"
         }
     }
     meddra-preferred-terms-cols = ["pt_code", "pt_name"]