From 3898cd01a58980f2ab3e0e640e16067521d10c02 Mon Sep 17 00:00:00 2001 From: Charles Tapley Hoyt Date: Mon, 26 Apr 2021 23:17:41 +0200 Subject: [PATCH] Rebuilt CONIB --- conib/_cache.bel.nodelink.json | 2 +- conib/_cache.bel.summary.json | 2 +- conib/_cache.bel.summary.tsv | 2 +- conib/_cache.bel.warnings.tsv | 2 +- .../kontsekova2014.bel.warnings.tsv | 2 +- docs/index.html | 197594 ++++++++++----- 6 files changed, 139757 insertions(+), 57847 deletions(-) diff --git a/conib/_cache.bel.nodelink.json b/conib/_cache.bel.nodelink.json index b865c3fc3..6f62d3f3c 100644 --- a/conib/_cache.bel.nodelink.json +++ b/conib/_cache.bel.nodelink.json @@ -352,7 +352,7 @@ "description": "Mechanistic knowledge surrounding several neurodegenerative diseases, with specific focus on protein aggregation, nicotinic receptor signalling, proteostasis, and other mechanisms.", "licenses": "CC BY 4.0", "name": "Curation of Neurodegeneration in BEL (CONIB)", - "version": "0.0.8-dev" + "version": "0.0.8" }, "namespace_pattern": { "BTO": "^\\d{7}$", diff --git a/conib/_cache.bel.summary.json b/conib/_cache.bel.summary.json index d6eb5d655..8df37abd6 100644 --- a/conib/_cache.bel.summary.json +++ b/conib/_cache.bel.summary.json @@ -1,6 +1,6 @@ { "Name": "Curation of Neurodegeneration in BEL (CONIB)", - "Version": "0.0.8-dev", + "Version": "0.0.8", "Authors": "Charles Tapley Hoyt, Daniel Domingo-Fern\u00e1ndez, Esther Wollert, Sandra Spalek, Rana Al Disi, Lingling Xu, Kristian Kolpeja, Yojana Gadiya, Trusha Adeshara, Stephan Gebel, Sepehr Golriz", "Number of Nodes": 8976, "Number of Namespaces": 37, diff --git a/conib/_cache.bel.summary.tsv b/conib/_cache.bel.summary.tsv index 9a34a505a..258d5add9 100644 --- a/conib/_cache.bel.summary.tsv +++ b/conib/_cache.bel.summary.tsv @@ -1,5 +1,5 @@ Name Version Authors Number of Nodes Number of Namespaces Number of Edges Number of Annotations Number of Citations Number of Authors Network Density Number of Components Number of Warnings Author -misc/damesquita2018.bel Curation of Neurodegeneration in BEL (CONIB) 0.0.8-dev Charles Tapley Hoyt, Daniel Domingo-Fernández, Esther Wollert, Sandra Spalek, Rana Al Disi, Lingling Xu, Kristian Kolpeja, Yojana Gadiya, Trusha Adeshara, Stephan Gebel, Sepehr Golriz 51 6 120 5 1 23 4.71E-02 1 0 +misc/damesquita2018.bel Curation of Neurodegeneration in BEL (CONIB) 0.0.8 Charles Tapley Hoyt, Daniel Domingo-Fernández, Esther Wollert, Sandra Spalek, Rana Al Disi, Lingling Xu, Kristian Kolpeja, Yojana Gadiya, Trusha Adeshara, Stephan Gebel, Sepehr Golriz 51 6 120 5 1 23 4.71E-02 1 0 misc/gant2018.bel FK506-Binding Protein 12.6/1b, a Negative Regulator of [Ca2], Rescues Memory and Restores Genomic Regulation in the Hippocampus of Aging Rats 1.0.0 30 5 51 3 1 7 5.86E-02 1 0 Lingling Xu misc/maniati2019.bel New insights into the role of microRNAs and long noncoding RNAs in most common neurodegenerative diseases 1.0.0 94 9 181 5 1 5 2.07E-02 2 0 Sandra Spalek misc/neurotransmitter_insulin_neurommsig_enrichment.bel Neurotransmitter and Insulin NeuroMMSig enrichments 0.0.1 Kristian Kolpeja, Daniel Domingo-Fernandez 121 13 234 6 16 90 1.61E-02 5 0 diff --git a/conib/_cache.bel.warnings.tsv b/conib/_cache.bel.warnings.tsv index 75699d01e..a50cbe820 100644 --- a/conib/_cache.bel.warnings.tsv +++ b/conib/_cache.bel.warnings.tsv @@ -4,7 +4,7 @@ Line Number Position Line Error Message 159 32 "bp(GO:aging) negativeCorrelation r(CONSO:""alpha-7-containing nAChR"")" InvalidFunctionSemantic "RNA CONSO:""alpha-7-containing nAChR"" should be encoded as one of: Complex" 218 66 "p(MESH:""Receptors, Nicotinic"",loc(MESH:""GABAergic Neurons"")) -- a(CONSO:neurotransmitters)" MissingNamespaceNameWarning """neurotransmitters"" is not in the CONSO namespace" 219 41 "p(MESH:""Receptors, Nicotinic"") reg sec(a(CONSO:neurotransmitters))" MissingNamespaceNameWarning """neurotransmitters"" is not in the CONSO namespace" -117 17 "p(CONSO:DC8E8) -- path(CONSO:""Braak_Stage I"")" InvalidFunctionSemantic "Pathology CONSO:""Braak_Stage I"" should be encoded as one of: miRNA, Abundance, Gene, Complex, Protein, RNA" +117 17 "p(CONSO:DC8E8) -- path(CONSO:""Braak_Stage I"")" InvalidFunctionSemantic "Pathology CONSO:""Braak_Stage I"" should be encoded as one of: miRNA, Gene, Complex, RNA, Abundance, Protein" 551 4 "SET MeSHDisease = ""Hypoxia""" UndefinedAnnotationWarning """MeSHDisease"" is not defined" 568 6 UNSET MeSHDisease UndefinedAnnotationWarning """MeSHDisease"" is not defined" 157 56 "p(CONSO:""Tau isoform F (441 aa)"", var(""p.Lys280del"")) -- a(CONSO:""Tau epitope, 12E8"")" InvalidFunctionSemantic "Abundance CONSO:""Tau epitope, 12E8"" should be encoded as one of: Protein" diff --git a/conib/immunotherapy/kontsekova2014.bel.warnings.tsv b/conib/immunotherapy/kontsekova2014.bel.warnings.tsv index 41040667a..9d060473b 100644 --- a/conib/immunotherapy/kontsekova2014.bel.warnings.tsv +++ b/conib/immunotherapy/kontsekova2014.bel.warnings.tsv @@ -1,2 +1,2 @@ Line Number Position Line Error Message -117 17 "p(CONSO:DC8E8) -- path(CONSO:""Braak_Stage I"")" InvalidFunctionSemantic "Pathology CONSO:""Braak_Stage I"" should be encoded as one of: miRNA, Abundance, Gene, Complex, Protein, RNA" +117 17 "p(CONSO:DC8E8) -- path(CONSO:""Braak_Stage I"")" InvalidFunctionSemantic "Pathology CONSO:""Braak_Stage I"" should be encoded as one of: miRNA, Gene, Complex, RNA, Abundance, Protein" diff --git a/docs/index.html b/docs/index.html index b761e0501..e08aa536d 100644 --- a/docs/index.html +++ b/docs/index.html @@ -1,29 +1,29 @@ - + - Human Brain Pharmacome Knowledge v0.0.5 + Curation of Neurodegeneration in BEL (CONIB) v0.0.8 - - - + + +
@@ -61,25 +61,25 @@
-

Human Brain Pharmacome Knowledge - 0.0.5 +

Curation of Neurodegeneration in BEL (CONIB) + 0.0.8

- Mechanistic knowledge surrounding three biological phenomena: tau modification/aggregation, nicotinic receptor signalling, and proteostasis in the context of neurodegenerative disease + Mechanistic knowledge surrounding several neurodegenerative diseases, with specific focus on protein aggregation, nicotinic receptor signalling, proteostasis, and other mechanisms.

Authors
-
Trusha Adeshara, Rana Al Disi, Daniel Domingo-Fernández, Yojana Gadiya, Charles Tapley Hoyt, Kristian Kolpeja, Sandra Spalek, Esther Wollert, Lingling Xu
+
Charles Tapley Hoyt, Daniel Domingo-Fernández, Esther Wollert, Sandra Spalek, Rana Al Disi, Lingling Xu, Kristian Kolpeja, Yojana Gadiya, Trusha Adeshara, Stephan Gebel, Sepehr Golriz
Contact
- charles.hoyt@scai.fraunhofer.de + cthoyt@gmail.com
License
-
CC BY 4.0
+
CC0 1.0 Universal
Copyright
@@ -90,26 +90,41 @@

Human Brain Pharmacome Knowledge

Summary

+
Name
+
Curation of Neurodegeneration in BEL (CONIB)
+ +
Version
+
0.0.8
+ +
Authors
+
Charles Tapley Hoyt, Daniel Domingo-Fernández, Esther Wollert, Sandra Spalek, Rana Al Disi, Lingling Xu, Kristian Kolpeja, Yojana Gadiya, Trusha Adeshara, Stephan Gebel, Sepehr Golriz
+
Number of Nodes
-
5862
+
8976
+ +
Number of Namespaces
+
37
Number of Edges
-
20860
+
32939
+ +
Number of Annotations
+
54
Number of Citations
-
353
+
568
Number of Authors
-
1969
+
3839
Network Density
-
6.07E-04
+
4.09E-04
Number of Components
-
34
+
30
Number of Warnings
-
35
+
55
@@ -134,8 +149,6 @@

Edges

-
-

Topology

@@ -166,19121 +179,19680 @@

Statements

- pmid:30046111 + pubmed:30046111 - tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:Blood), toLoc(MESH:"Cerebrospinal Fluid")) regulates deg(a(CHEBI:"amyloid-beta")) + tloc(a(CHEBI:amyloid-beta), fromLoc(MESH:Blood), toLoc(MESH:"Cerebrospinal Fluid")) regulates deg(a(CHEBI:amyloid-beta)) - pmid:29626319 + pubmed:27299292 - tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:Brain), toLoc(MESH:Blood)) decreases a(CHEBI:"amyloid-beta") + a(CHEBI:amyloid-beta, loc(MESH:Astrocytes)) increases deg(a(CHEBI:amyloid-beta)) - pmid:30046111 + pubmed:29626319 - a(CHEBI:"amyloid-beta") negativeCorrelation act(a(MESH:"Lymphatic Vessels")) + tloc(a(CHEBI:amyloid-beta), fromLoc(MESH:Brain), toLoc(MESH:Blood)) decreases a(CHEBI:amyloid-beta) - pmid:30046111 + pubmed:30046111 - a(CHEBI:"amyloid-beta") positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:amyloid-beta) negativeCorrelation act(a(MESH:"Lymphatic Vessels")) - pmid:30046111 + pubmed:30046111 - a(CHEBI:"amyloid-beta") positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:amyloid-beta) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:30046111 + pubmed:30046111 - a(CHEBI:"amyloid-beta") positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:amyloid-beta) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:29196815 + pubmed:30046111 - a(CHEBI:"amyloid-beta") positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:amyloid-beta) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:29196815 + pubmed:29196815 - a(CHEBI:"amyloid-beta") positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:amyloid-beta) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:19293145 + pubmed:29196815 - a(CHEBI:"amyloid-beta") increases path(MESH:"Alzheimer Disease") + a(CHEBI:amyloid-beta) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:19293145 + pubmed:23556446 - sec(a(CHEBI:"amyloid-beta")) association path(MESH:"Alzheimer Disease") + a(CHEBI:amyloid-beta) increases path(MESH:"Alzheimer Disease") - pmid:19293145 + pubmed:19293145 - a(CHEBI:"amyloid-beta") association path(MESH:"Alzheimer Disease") + a(CHEBI:amyloid-beta) increases path(MESH:"Alzheimer Disease") - pmid:25514383 + pubmed:19293145 - a(CHEBI:"amyloid-beta") positiveCorrelation path(MESH:"Alzheimer Disease") + tloc(a(CHEBI:amyloid-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association path(MESH:"Alzheimer Disease") - pmid:11230871 + pubmed:19293145 - a(CHEBI:"amyloid-beta") increases path(MESH:"Alzheimer Disease") + a(CHEBI:amyloid-beta) association path(MESH:"Alzheimer Disease") - pmid:14556719 + pubmed:25514383 - a(CHEBI:"amyloid-beta") association path(MESH:"Alzheimer Disease") + a(CHEBI:amyloid-beta) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:29980653 + pubmed:11230871 - a(CHEBI:"amyloid-beta") positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:amyloid-beta) increases path(MESH:"Alzheimer Disease") - pmid:30046111 + pubmed:14556719 - a(CHEBI:"amyloid-beta") association a(MESH:Macrophages) + a(CHEBI:amyloid-beta) association path(MESH:"Alzheimer Disease") - pmid:28745240 + pubmed:29980653 - a(CHEBI:"amyloid-beta") decreases bp(GO:"calcium ion homeostasis") + a(CHEBI:amyloid-beta) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:28745240 + pubmed:30046111 - a(CHEBI:"amyloid-beta") association bp(MESH:"Oxidative Stress") + a(CHEBI:amyloid-beta) association a(MESH:Macrophages) - pmid:28745240 + pubmed:30663117 - a(CHEBI:"amyloid-beta") increases bp(MESH:"Oxidative Stress") + a(CHEBI:amyloid-beta) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:28745240 + pubmed:19293145 - a(CHEBI:"amyloid-beta") increases bp(GO:"apoptotic process") + a(CHEBI:amyloid-beta) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:28745240 + pubmed:26813123 - a(CHEBI:"amyloid-beta") increases bp(GO:"apoptotic process") + a(CHEBI:amyloid-beta) regulates p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:19293145 + pubmed:28745240 - act(a(CHEBI:"amyloid-beta")) increases bp(GO:"apoptotic process") + a(CHEBI:amyloid-beta) decreases bp(GO:"calcium ion homeostasis") - pmid:28745240 + pubmed:28745240 - a(CHEBI:"amyloid-beta") increases bp(GO:"JNK cascade") + a(CHEBI:amyloid-beta) association bp(MESH:"Oxidative Stress") - pmid:28745240 + pubmed:28745240 - a(CHEBI:"amyloid-beta") increases bp(GO:"Fas signaling pathway") + a(CHEBI:amyloid-beta) increases bp(MESH:"Oxidative Stress") - pmid:28745240 + pubmed:28745240 - a(CHEBI:"amyloid-beta") increases act(complex(GO:"NF-kappaB complex")) + a(CHEBI:amyloid-beta) increases bp(GO:"apoptotic process") - pmid:28745240 + pubmed:28745240 - a(CHEBI:"amyloid-beta") increases act(complex(GO:"NF-kappaB complex")) + a(CHEBI:amyloid-beta) increases bp(GO:"apoptotic process") - pmid:28745240 + pubmed:27288790 - a(CHEBI:"amyloid-beta") increases complex(GO:"NF-kappaB complex") + a(CHEBI:amyloid-beta) increases bp(GO:"apoptotic process") - pmid:28745240 + pubmed:19293145 - a(CHEBI:"amyloid-beta") increases act(complex(GO:"NF-kappaB complex")) + act(a(CHEBI:amyloid-beta)) increases bp(GO:"apoptotic process") - pmid:28745240 + pubmed:28745240 - a(CHEBI:"amyloid-beta") increases act(complex(GO:"NF-kappaB complex")) + a(CHEBI:amyloid-beta) increases bp(GO:"JNK cascade") - pmid:25652642 + pubmed:28745240 - a(CHEBI:"amyloid-beta") increases act(complex(GO:"NF-kappaB complex")) + a(CHEBI:amyloid-beta) increases bp(GO:"Fas signaling pathway") - pmid:25652642 + pubmed:28745240 - a(CHEBI:"amyloid-beta") positiveCorrelation act(complex(GO:"NF-kappaB complex")) + a(CHEBI:amyloid-beta) increases act(complex(GO:"NF-kappaB complex")) - pmid:25652642 + pubmed:28745240 - a(CHEBI:"amyloid-beta") decreases act(complex(GO:"NF-kappaB complex")) + a(CHEBI:amyloid-beta) increases act(complex(GO:"NF-kappaB complex")) - pmid:25652642 + pubmed:28745240 - a(CHEBI:"amyloid-beta") increases act(complex(GO:"NF-kappaB complex")) + a(CHEBI:amyloid-beta) increases complex(GO:"NF-kappaB complex") - pmid:28745240 + pubmed:28745240 - a(CHEBI:"amyloid-beta") decreases p(HGNC:BCL2L1) + a(CHEBI:amyloid-beta) increases act(complex(GO:"NF-kappaB complex")) - pmid:25652642 + pubmed:28745240 - a(CHEBI:"amyloid-beta") decreases p(HGNC:BCL2L1) + a(CHEBI:amyloid-beta) increases act(complex(GO:"NF-kappaB complex")) - pmid:28745240 + pubmed:25652642 - a(CHEBI:"amyloid-beta") decreases sec(a(PUBCHEM:16057918)) + a(CHEBI:amyloid-beta) increases act(complex(GO:"NF-kappaB complex")) - pmid:28745240 + pubmed:25652642 - a(CHEBI:"amyloid-beta") increases complex(a(GO:"membrane attack complex"), p(HGNC:C5)) + a(CHEBI:amyloid-beta) positiveCorrelation act(complex(GO:"NF-kappaB complex")) - pmid:28745240 + pubmed:25652642 - a(CHEBI:"amyloid-beta") increases p(HGNC:TNF) + a(CHEBI:amyloid-beta) decreases act(complex(GO:"NF-kappaB complex")) - pmid:29179999 + pubmed:25652642 - a(CHEBI:"amyloid-beta") increases sec(p(HGNC:TNF)) + a(CHEBI:amyloid-beta) increases act(complex(GO:"NF-kappaB complex")) - pmid:28019679 + pubmed:28745240 - a(CHEBI:"amyloid-beta") increases sec(p(HGNC:TNF)) + a(CHEBI:amyloid-beta) decreases p(HGNC:BCL2L1) - pmid:28745240 + pubmed:28745240 - a(CHEBI:"amyloid-beta") increases p(HGNC:APP) + a(CHEBI:amyloid-beta) decreases tloc(a(PUBCHEM:16057918), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:18930136 + pubmed:28745240 - a(CHEBI:"amyloid-beta") association deg(p(HGNC:APP)) + a(CHEBI:amyloid-beta) increases complex(a(GO:"membrane attack complex"), p(HGNC:C5)) - pmid:28745240 + pubmed:28745240 - a(CHEBI:"amyloid-beta") increases act(complex(GO:"calcium- and calmodulin-dependent protein kinase complex")) + a(CHEBI:amyloid-beta) increases p(HGNC:TNF) - pmid:28745240 + pubmed:29179999 - a(CHEBI:"amyloid-beta") regulates act(p(FPLX:PKC)) + a(CHEBI:amyloid-beta) increases tloc(p(HGNC:TNF), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:28745240 + pubmed:28019679 - a(CHEBI:"amyloid-beta") regulates bp(HBP:"PI3K-Akt signaling pathway") + a(CHEBI:amyloid-beta) increases tloc(p(HGNC:TNF), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:28745240 + pubmed:28745240 - a(CHEBI:"amyloid-beta") increases path(HBP:neurotoxicity) + a(CHEBI:amyloid-beta) increases p(HGNC:APP) - pmid:25652642 + pubmed:18930136 - a(CHEBI:"amyloid-beta") increases path(HBP:neurotoxicity) + a(CHEBI:amyloid-beta) association deg(p(HGNC:APP)) - pmid:19293145 + pubmed:28745240 - a(CHEBI:"amyloid-beta") increases path(HBP:neurotoxicity) + a(CHEBI:amyloid-beta) increases act(complex(GO:"calcium- and calmodulin-dependent protein kinase complex")) - pmid:19293145 + pubmed:28745240 - act(a(CHEBI:"amyloid-beta")) increases path(HBP:neurotoxicity) + a(CHEBI:amyloid-beta) regulates act(p(FPLX:PKC)) - pmid:19293145 + pubmed:28745240 - act(a(CHEBI:"amyloid-beta")) increases path(HBP:neurotoxicity) + a(CHEBI:amyloid-beta) regulates bp(CONSO:"PI3K-Akt signaling pathway") - pmid:19293145 + pubmed:28745240 - act(a(CHEBI:"amyloid-beta")) increases path(HBP:neurotoxicity) + a(CHEBI:amyloid-beta) increases path(CONSO:neurotoxicity) - pmid:24590577 + pubmed:25652642 - a(CHEBI:"amyloid-beta") increases path(HBP:neurotoxicity) + a(CHEBI:amyloid-beta) increases path(CONSO:neurotoxicity) - pmid:21882945 + pubmed:19293145 - a(CHEBI:"amyloid-beta") increases path(HBP:neurotoxicity) + a(CHEBI:amyloid-beta) increases path(CONSO:neurotoxicity) - pmid:28745240 + pubmed:19293145 - a(CHEBI:"amyloid-beta") increases a(CHEBI:"calcium(2+)") + act(a(CHEBI:amyloid-beta)) increases path(CONSO:neurotoxicity) - pmid:28745240 + pubmed:19293145 - a(CHEBI:"amyloid-beta") increases act(a(MESH:Microglia)) + act(a(CHEBI:amyloid-beta)) increases path(CONSO:neurotoxicity) - pmid:29179999 + pubmed:19293145 - a(CHEBI:"amyloid-beta") increases bp(GO:"glial cell activation") + a(CHEBI:amyloid-beta) increases path(CONSO:neurotoxicity) - pmid:29179999 + pubmed:19293145 - a(CHEBI:"amyloid-beta") increases bp(GO:"inflammatory response") + act(a(CHEBI:amyloid-beta)) increases path(CONSO:neurotoxicity) - pmid:16566606 + pubmed:24590577 - a(CHEBI:"amyloid-beta") increases bp(GO:"inflammatory response") + a(CHEBI:amyloid-beta) increases path(CONSO:neurotoxicity) - pmid:29179999 + pubmed:21882945 - a(CHEBI:"amyloid-beta") increases sec(p(HGNC:IL1B)) + a(CHEBI:amyloid-beta) increases path(CONSO:neurotoxicity) - pmid:29179999 + pubmed:28745240 - a(CHEBI:"amyloid-beta") increases sec(p(HGNC:IL6)) + a(CHEBI:amyloid-beta) increases a(CHEBI:"calcium(2+)") - pmid:29179999 + pubmed:30688256 - a(CHEBI:"amyloid-beta") increases act(p(FPLX:NFkappaB)) + a(CHEBI:amyloid-beta, loc(MESH:Mitochondria)) increases a(CHEBI:"calcium(2+)") - pmid:27288790 + pubmed:28745240 - a(CHEBI:"amyloid-beta") increases act(p(FPLX:NFkappaB)) + a(CHEBI:amyloid-beta) increases act(a(MESH:Microglia)) - pmid:26010758 + pubmed:29179999 - a(CHEBI:"amyloid-beta") increases act(p(FPLX:NFkappaB)) + a(CHEBI:amyloid-beta) increases bp(GO:"glial cell activation") - pmid:27288790 + pubmed:29179999 - a(CHEBI:"amyloid-beta") increases act(p(HGNC:NFKB1)) + a(CHEBI:amyloid-beta) increases bp(GO:"inflammatory response") - pmid:27288790 + pubmed:16566606 - a(CHEBI:"amyloid-beta") increases act(p(HGNC:RELA)) + a(CHEBI:amyloid-beta) increases bp(GO:"inflammatory response") - pmid:25652642 + pubmed:29179999 - a(CHEBI:"amyloid-beta") increases act(p(HGNC:APOE)) + a(CHEBI:amyloid-beta) increases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:26195256 + pubmed:29179999 - tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Cardiovascular System")) negativeCorrelation tloc(p(HGNC:APOE), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Cardiovascular System")) + a(CHEBI:amyloid-beta) increases tloc(p(HGNC:IL6), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:25652642 + pubmed:29179999 - a(CHEBI:"amyloid-beta") increases bp(GO:"neuron death") + a(CHEBI:amyloid-beta) increases act(p(FPLX:NFkappaB)) - pmid:21214928 + pubmed:27288790 - a(CHEBI:"amyloid-beta") increases bp(GO:"neuron death") + a(CHEBI:amyloid-beta) increases act(p(FPLX:NFkappaB)) - pmid:22122372 + pubmed:26010758 - a(CHEBI:"amyloid-beta") increases bp(GO:"neuron death") + a(CHEBI:amyloid-beta) increases act(p(FPLX:NFkappaB)) - pmid:22122372 + pubmed:27288790 - a(CHEBI:"amyloid-beta") increases bp(GO:"neuron death") + a(CHEBI:amyloid-beta) increases act(p(HGNC:NFKB1)) - pmid:25652642 + pubmed:27288790 - a(CHEBI:"amyloid-beta") increases p(HGNC:BAX) + a(CHEBI:amyloid-beta) increases act(p(HGNC:RELA)) - pmid:19293145 + pubmed:25652642 - a(CHEBI:"amyloid-beta") increases p(HGNC:BAX) + a(CHEBI:amyloid-beta) increases act(p(HGNC:APOE)) - pmid:19293145 + pubmed:26195256 - a(CHEBI:"amyloid-beta") increases act(p(HGNC:BAX)) + tloc(a(CHEBI:amyloid-beta), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Cardiovascular System")) negativeCorrelation tloc(p(HGNC:APOE), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Cardiovascular System")) - pmid:25652642 + pubmed:25652642 - a(CHEBI:"amyloid-beta") increases a(MESH:"I-kappa B Proteins") + a(CHEBI:amyloid-beta) increases bp(GO:"neuron death") - pmid:30232325 + pubmed:21214928 - a(CHEBI:"amyloid-beta") increases bp(HBP:HBP00061) + a(CHEBI:amyloid-beta) increases bp(GO:"neuron death") - pmid:21214928 + pubmed:22122372 - a(CHEBI:"amyloid-beta") increases bp(HBP:HBP00061) + a(CHEBI:amyloid-beta) increases bp(GO:"neuron death") - pmid:22122372 + pubmed:22122372 - a(CHEBI:"amyloid-beta") increases bp(HBP:HBP00061) + a(CHEBI:amyloid-beta) increases bp(GO:"neuron death") - pmid:22122372 + pubmed:25652642 - a(CHEBI:"amyloid-beta") increases bp(HBP:HBP00061) + a(CHEBI:amyloid-beta) increases r(HGNC:BAX) - pmid:29196815 + pubmed:25652642 - a(CHEBI:"amyloid-beta") increases bp(GO:"neuron apoptotic process") + a(CHEBI:amyloid-beta) decreases r(HGNC:BCL2L1) - pmid:29196815 + pubmed:25652642 - a(CHEBI:"amyloid-beta") increases complex(GO:"neurofibrillary tangle") + a(CHEBI:amyloid-beta) increases a(MESH:"I-kappa B Proteins", loc(GO:cytoplasm)) - pmid:29196815 + pubmed:29844403 - a(CHEBI:"amyloid-beta") increases path(MESH:Gliosis) + a(CHEBI:amyloid-beta) increases p(CONSO:"Tau aggregates") - pmid:29196815 + pubmed:28500862 - a(CHEBI:"amyloid-beta") increases path(MESH:"Neuroaxonal Dystrophies") + a(CHEBI:amyloid-beta) positiveCorrelation p(CONSO:"Tau aggregates") - pmid:18650430 + pubmed:29844403 - a(CHEBI:"amyloid-beta") increases bp(GO:"cell adhesion") + a(CHEBI:amyloid-beta) increases p(MESH:"Neurofibrillary Tangles") - pmid:21214928 + pubmed:30232325 - a(CHEBI:"amyloid-beta") increases path(MESH:"Plaque, Amyloid") + a(CHEBI:amyloid-beta) increases path(CONSO:CONSO00061) - pmid:21214928 + pubmed:21214928 - a(CHEBI:"amyloid-beta") increases path(MESH:"Plaque, Amyloid") + a(CHEBI:amyloid-beta) increases path(CONSO:CONSO00061) - pmid:21214928 + pubmed:22122372 - a(CHEBI:"amyloid-beta") increases bp(HBP:HBP00027) + a(CHEBI:amyloid-beta) increases path(CONSO:CONSO00061) - pmid:21214928 + pubmed:22122372 - a(CHEBI:"amyloid-beta") decreases bp(GO:"regulation of synapse structure or activity") + a(CHEBI:amyloid-beta) increases path(CONSO:CONSO00061) - pmid:21214928 + pubmed:29196815 - a(CHEBI:"amyloid-beta") decreases bp(GO:"regulation of synapse structure or activity") + a(CHEBI:amyloid-beta) increases bp(GO:"neuron apoptotic process") - pmid:22122372 + pubmed:29196815 - a(CHEBI:"amyloid-beta") decreases bp(GO:"regulation of synapse structure or activity") + a(CHEBI:amyloid-beta) increases complex(GO:"neurofibrillary tangle") - pmid:22122372 + pubmed:29196815 - a(CHEBI:"amyloid-beta") decreases bp(GO:"regulation of synapse structure or activity") + a(CHEBI:amyloid-beta) increases path(MESH:Gliosis) - pmid:21214928 + pubmed:29196815 - a(CHEBI:"amyloid-beta") increases bp(GO:"neurofibrillary tangle assembly") + a(CHEBI:amyloid-beta) increases path(MESH:"Neuroaxonal Dystrophies") - pmid:22122372 + pubmed:18650430 - a(CHEBI:"amyloid-beta") increases bp(GO:"neurofibrillary tangle assembly") + a(CHEBI:amyloid-beta) increases bp(GO:"cell adhesion") - pmid:21214928 + pubmed:21214928 - a(CHEBI:"amyloid-beta") association bp(GO:"MAPK cascade") + a(CHEBI:amyloid-beta) increases path(MESH:"Plaque, Amyloid") - pmid:21214928 + pubmed:21214928 - a(CHEBI:"amyloid-beta") association bp(GO:"ERK1 and ERK2 cascade") + a(CHEBI:amyloid-beta) increases path(MESH:"Plaque, Amyloid") + + - pmid:21214928 + pubmed:21214928 - a(CHEBI:"amyloid-beta") decreases a(MESH:Synapses) + a(CHEBI:amyloid-beta) increases path(CONSO:CONSO00027) - pmid:19293145 + pubmed:21214928 - a(CHEBI:"amyloid-beta") decreases a(MESH:Synapses) + a(CHEBI:amyloid-beta) decreases bp(GO:"regulation of synapse structure or activity") - pmid:21214928 + pubmed:21214928 - a(CHEBI:"amyloid-beta") decreases bp(GO:memory) + a(CHEBI:amyloid-beta) decreases bp(GO:"regulation of synapse structure or activity") - pmid:25514383 + pubmed:22122372 - a(CHEBI:"amyloid-beta") increases bp(GO:memory) + a(CHEBI:amyloid-beta) decreases bp(GO:"regulation of synapse structure or activity") - pmid:29758300 + pubmed:22122372 - sec(a(CHEBI:"amyloid-beta")) increases bp(GO:memory) + a(CHEBI:amyloid-beta) decreases bp(GO:"regulation of synapse structure or activity") - pmid:22908190 + pubmed:21214928 - a(CHEBI:"amyloid-beta") decreases bp(GO:memory) + a(CHEBI:amyloid-beta) increases bp(GO:"neurofibrillary tangle assembly") - pmid:21214928 + pubmed:22122372 - a(CHEBI:"amyloid-beta") association bp(MESH:"Synaptic Transmission") + a(CHEBI:amyloid-beta) increases bp(GO:"neurofibrillary tangle assembly") - pmid:21214928 + pubmed:21214928 - a(CHEBI:"amyloid-beta") decreases bp(GO:"long-term synaptic potentiation") + a(CHEBI:amyloid-beta) association bp(GO:"MAPK cascade") - pmid:21214928 + pubmed:21214928 - a(CHEBI:"amyloid-beta") association a(MESH:"Potassium Channels") + a(CHEBI:amyloid-beta) association bp(GO:"ERK1 and ERK2 cascade") + + - pmid:21214928 + pubmed:21214928 - a(CHEBI:"amyloid-beta") increases bp(GO:"cell death") + a(CHEBI:amyloid-beta) decreases a(MESH:Synapses) - pmid:21214928 + pubmed:19293145 - a(CHEBI:"amyloid-beta") association complex(p(HGNC:APBA1), p(HGNC:APP)) + a(CHEBI:amyloid-beta) decreases a(MESH:Synapses) - pmid:21214928 + pubmed:21214928 - sec(a(CHEBI:"amyloid-beta")) association complex(p(HGNC:APBA1), p(HGNC:APP)) + a(CHEBI:amyloid-beta) decreases bp(GO:memory) - pmid:21214928 + pubmed:25514383 - a(CHEBI:"amyloid-beta") association complex(p(HGNC:APBA2), p(HGNC:APP)) + a(CHEBI:amyloid-beta) increases bp(GO:memory) - pmid:21214928 + pubmed:29758300 - sec(a(CHEBI:"amyloid-beta")) association complex(p(HGNC:APBA2), p(HGNC:APP)) + tloc(a(CHEBI:amyloid-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) increases bp(GO:memory) - pmid:21214928 + pubmed:22908190 - a(CHEBI:"amyloid-beta") association complex(p(HGNC:APBA3), p(HGNC:APP)) + a(CHEBI:amyloid-beta) decreases bp(GO:memory) - pmid:21214928 + pubmed:21214928 - sec(a(CHEBI:"amyloid-beta")) association complex(p(HGNC:APBA3), p(HGNC:APP)) + a(CHEBI:amyloid-beta) association bp(MESH:"Synaptic Transmission") - pmid:21214928 + pubmed:21214928 - a(CHEBI:"amyloid-beta") association a(CHEBI:"phorbol ester") + a(CHEBI:amyloid-beta) decreases bp(GO:"long-term synaptic potentiation") - pmid:22122372 + pubmed:21214928 - a(CHEBI:"amyloid-beta") decreases bp(GO:"learning or memory") + a(CHEBI:amyloid-beta) association a(MESH:"Potassium Channels") - pmid:22122372 + pubmed:21214928 - a(CHEBI:"amyloid-beta") increases a(HBP:HBP00038) + a(CHEBI:amyloid-beta) increases bp(GO:"cell death") - pmid:22122372 + pubmed:21214928 - a(CHEBI:"amyloid-beta") increases a(HBP:HBP00018) + a(CHEBI:amyloid-beta) association complex(p(HGNC:APBA1), p(HGNC:APP)) - pmid:30061532 + pubmed:21214928 - a(CHEBI:"amyloid-beta") association path(MESH:"Lewy Body Disease") + tloc(a(CHEBI:amyloid-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association complex(p(HGNC:APBA1), p(HGNC:APP)) - pmid:19293145 + pubmed:21214928 - a(CHEBI:"amyloid-beta") association bp(GO:"synaptic transmission, cholinergic") + a(CHEBI:amyloid-beta) association complex(p(HGNC:APBA2), p(HGNC:APP)) - pmid:19293145 + pubmed:21214928 - a(CHEBI:"amyloid-beta") association bp(GO:"synaptic transmission, cholinergic") + tloc(a(CHEBI:amyloid-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association complex(p(HGNC:APBA2), p(HGNC:APP)) - pmid:19293145 + pubmed:21214928 - a(CHEBI:"amyloid-beta") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + a(CHEBI:amyloid-beta) association complex(p(HGNC:APBA3), p(HGNC:APP)) - pmid:19293145 + pubmed:21214928 - a(CHEBI:"amyloid-beta") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + tloc(a(CHEBI:amyloid-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association complex(p(HGNC:APBA3), p(HGNC:APP)) - pmid:19293145 + pubmed:21214928 - a(CHEBI:"amyloid-beta") association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + a(CHEBI:amyloid-beta) association a(CHEBI:"phorbol ester") - pmid:19293145 + pubmed:22122372 - a(CHEBI:"amyloid-beta") decreases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + a(CHEBI:amyloid-beta) decreases bp(GO:"learning or memory") - pmid:19293145 + pubmed:22122372 - a(CHEBI:"amyloid-beta") decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + a(CHEBI:amyloid-beta) increases a(CONSO:CONSO00038) - pmid:19293145 + pubmed:22122372 - a(CHEBI:"amyloid-beta") positiveCorrelation p(HGNC:CHRNA7) + a(CHEBI:amyloid-beta) increases a(CONSO:CONSO00018) - pmid:19293145 + pubmed:21156028 - a(CHEBI:"amyloid-beta") increases act(p(HGNC:CHRNA7)) + a(CHEBI:amyloid-beta) increases p(HGNC:DYRK1A) - pmid:19293145 + pubmed:22262751 - a(CHEBI:"amyloid-beta") association p(HGNC:CHRNA7) + a(CHEBI:amyloid-beta) association g(DBSNP:rs6656401) + + - pmid:19293145 + pubmed:19419557 - a(CHEBI:"amyloid-beta") decreases act(p(HGNC:CHRNA7)) + a(CHEBI:amyloid-beta) association bp(GO:"calcium-mediated signaling") - pmid:19293145 + pubmed:19293145 - a(CHEBI:"amyloid-beta") causesNoChange p(HGNC:CHRNA7) + act(a(CHEBI:amyloid-beta)) association bp(GO:"calcium-mediated signaling") - pmid:19293145 + pubmed:26027813 - a(CHEBI:"amyloid-beta") causesNoChange act(p(HGNC:CHRNA7)) + a(CHEBI:amyloid-beta) association a(NIFT:"Cortical Thickness") - pmid:19293145 + pubmed:26996954 - a(CHEBI:"amyloid-beta") increases p(HGNC:CHRNA7) + a(CHEBI:amyloid-beta) positiveCorrelation a(NIFT:"Grey matter atrophy") - pmid:17009926 + pubmed:30061532 - a(CHEBI:"amyloid-beta") positiveCorrelation p(HGNC:CHRNA7) + a(CHEBI:amyloid-beta) association path(MESH:"Lewy Body Disease") + + - pmid:19293145 + pubmed:30515821 - a(CHEBI:"amyloid-beta") positiveCorrelation p(HGNC:CHRNA4) + a(CHEBI:amyloid-beta) increases act(p(HGNC:CDK5)) - pmid:19293145 + pubmed:30515821 - a(CHEBI:"amyloid-beta") increases p(HGNC:CHRNA4) + a(CHEBI:amyloid-beta) increases p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 579)) + + - pmid:17009926 + pubmed:19293145 - a(CHEBI:"amyloid-beta") positiveCorrelation p(HGNC:CHRNA4) + a(CHEBI:amyloid-beta) association bp(GO:"synaptic transmission, cholinergic") - pmid:19293145 + pubmed:19293145 - a(CHEBI:"amyloid-beta") increases bp(GO:"intracellular receptor signaling pathway") + a(CHEBI:amyloid-beta) association bp(GO:"synaptic transmission, cholinergic") - pmid:19293145 + pubmed:19293145 - act(a(CHEBI:"amyloid-beta")) association p(HGNC:FYN) + a(CHEBI:amyloid-beta) association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:19293145 + pubmed:19293145 - a(CHEBI:"amyloid-beta") increases act(p(HGNC:FYN)) + a(CHEBI:amyloid-beta) association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:19293145 + pubmed:19293145 - a(CHEBI:"amyloid-beta") increases act(p(FPLX:PI3K)) + a(CHEBI:amyloid-beta) association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:19293145 + pubmed:19293145 - a(CHEBI:"amyloid-beta") increases p(HGNC:MAPT, pmod(Ph, Tyr)) + a(CHEBI:amyloid-beta) decreases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:19293145 + pubmed:19293145 - act(a(CHEBI:"amyloid-beta")) association bp(GO:"calcium-mediated signaling") + a(CHEBI:amyloid-beta) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:19293145 + pubmed:19293145 - a(CHEBI:"amyloid-beta") increases act(p(HGNC:MAPK8)) + a(CHEBI:amyloid-beta) positiveCorrelation p(HGNC:CHRNA7) - pmid:19293145 + pubmed:19293145 - a(CHEBI:"amyloid-beta") increases act(p(HGNC:MAPK14)) + a(CHEBI:amyloid-beta) increases act(p(HGNC:CHRNA7)) - pmid:19293145 + pubmed:19293145 - a(CHEBI:"amyloid-beta") causesNoChange path(HBP:Neurodegeneration) + a(CHEBI:amyloid-beta) association p(HGNC:CHRNA7) - pmid:29758300 + pubmed:19293145 - sec(a(CHEBI:"amyloid-beta")) decreases path(HBP:Neurodegeneration) + a(CHEBI:amyloid-beta) decreases act(p(HGNC:CHRNA7)) - pmid:19293145 + pubmed:19293145 - a(CHEBI:"amyloid-beta") decreases bp(MESH:"Neuronal Outgrowth") + a(CHEBI:amyloid-beta) causesNoChange p(HGNC:CHRNA7) - pmid:19293145 + pubmed:19293145 - a(CHEBI:"amyloid-beta") decreases act(a(CHEBI:carbachol), ma(MESH:Hydrolysis)) + a(CHEBI:amyloid-beta) causesNoChange act(p(HGNC:CHRNA7)) - pmid:19293145 + pubmed:19293145 - a(CHEBI:"amyloid-beta") increases p(HGNC:MAPK1, pmod(Ph)) + a(CHEBI:amyloid-beta) increases p(HGNC:CHRNA7) - pmid:19293145 + pubmed:17009926 - a(CHEBI:"amyloid-beta") decreases p(HGNC:BCL2) + a(CHEBI:amyloid-beta) positiveCorrelation p(HGNC:CHRNA7) - pmid:19293145 + pubmed:19293145 - a(CHEBI:"amyloid-beta") decreases act(p(HGNC:BCL2)) + a(CHEBI:amyloid-beta) positiveCorrelation p(HGNC:CHRNA4) - pmid:19293145 + pubmed:19293145 - a(CHEBI:"amyloid-beta") increases p(HGNC:MAPT, pmod(Ph)) + a(CHEBI:amyloid-beta) increases p(HGNC:CHRNA4) - pmid:26813123 + pubmed:17009926 - a(CHEBI:"amyloid-beta") regulates p(HGNC:MAPT, pmod(Ph)) + a(CHEBI:amyloid-beta) positiveCorrelation p(HGNC:CHRNA4) - pmid:19293145 + pubmed:19293145 - a(CHEBI:"amyloid-beta") increases act(p(FPLX:JNK)) + a(CHEBI:amyloid-beta) increases bp(GO:"intracellular receptor signaling pathway") - pmid:19293145 + pubmed:19293145 - a(CHEBI:"amyloid-beta") increases act(p(FPLX:ERK)) + act(a(CHEBI:amyloid-beta)) association p(HGNC:FYN) - pmid:19293145 + pubmed:19293145 - a(CHEBI:"amyloid-beta") increases act(p(HGNC:BAD)) + a(CHEBI:amyloid-beta) increases act(p(HGNC:FYN)) - pmid:19293145 + pubmed:19293145 - a(CHEBI:"amyloid-beta") association bp(GO:"choline transport") + a(CHEBI:amyloid-beta) increases act(p(FPLX:PI3K)) - pmid:19293145 + pubmed:19293145 - a(CHEBI:"amyloid-beta") increases act(p(HGNC:CHRNA7, var("p.L250T"))) + a(CHEBI:amyloid-beta) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr)) + + + + - pmid:19293145 + pubmed:19293145 - a(CHEBI:"amyloid-beta") increases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) + a(CHEBI:amyloid-beta) increases act(p(HGNC:MAPK8)) - pmid:19293145 + pubmed:19293145 - a(CHEBI:"amyloid-beta") decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) + a(CHEBI:amyloid-beta) increases act(p(HGNC:MAPK14)) - pmid:19293145 + pubmed:19293145 - a(CHEBI:"amyloid-beta") decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) + a(CHEBI:amyloid-beta) causesNoChange path(CONSO:Neurodegeneration) - pmid:19293145 + pubmed:29758300 - a(CHEBI:"amyloid-beta") causesNoChange act(complex(p(HGNC:CHRNA3), p(HGNC:CHRNB4))) + tloc(a(CHEBI:amyloid-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) decreases path(CONSO:Neurodegeneration) - pmid:19293145 + pubmed:19293145 - a(CHEBI:"amyloid-beta") decreases act(complex(p(HGNC:CHRNA2), p(HGNC:CHRNB2))) + a(CHEBI:amyloid-beta) decreases bp(MESH:"Neuronal Outgrowth") - pmid:19293145 + pubmed:19293145 - a(CHEBI:"amyloid-beta") decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNA5), p(HGNC:CHRNB2))) + a(CHEBI:amyloid-beta) decreases act(a(CHEBI:carbachol)) + + - pmid:19293145 + pubmed:19293145 - a(CHEBI:"amyloid-beta") decreases act(p(HGNC:CHRNA7, var("?"))) + a(CHEBI:amyloid-beta) increases p(HGNC:MAPK1, pmod(go:0006468 ! "protein phosphorylation")) - pmid:19293145 + pubmed:19293145 - a(CHEBI:"amyloid-beta") decreases act(a(CHEBI:nicotine)) + a(CHEBI:amyloid-beta) increases p(HGNC:BAX) - pmid:19293145 + pubmed:19293145 - a(CHEBI:"amyloid-beta") increases p(HGNC:CHRNA3) + a(CHEBI:amyloid-beta) increases act(p(HGNC:BAX)) - pmid:19293145 + pubmed:19293145 - a(CHEBI:"amyloid-beta") decreases p(RGD:Chrna4) + a(CHEBI:amyloid-beta) decreases p(HGNC:BCL2) - pmid:19293145 + pubmed:19293145 - a(CHEBI:"amyloid-beta") decreases p(RGD:Chrna7) + a(CHEBI:amyloid-beta) decreases act(p(HGNC:BCL2)) + + - pmid:19293145 + pubmed:22530628 - a(CHEBI:"amyloid-beta") increases r(RGD:Chrna7) + a(CHEBI:amyloid-beta) increases complex(a(CHEBI:amyloid-beta), p(HGNC:CHRNA7)) - pmid:19293145 + pubmed:19293145 - a(CHEBI:"amyloid-beta") increases p(MGI:Chat) + a(CHEBI:amyloid-beta) increases act(p(FPLX:JNK)) - pmid:19293145 + pubmed:19293145 - a(CHEBI:"amyloid-beta") increases r(MGI:Chrna3) + a(CHEBI:amyloid-beta) increases act(p(FPLX:ERK)) - pmid:17009926 + pubmed:19293145 - a(CHEBI:"amyloid-beta") decreases a(CHEBI:acetylcholine) + a(CHEBI:amyloid-beta) increases act(p(HGNC:BAD)) - pmid:17009926 + pubmed:19293145 - a(CHEBI:"amyloid-beta") decreases sec(a(CHEBI:acetylcholine)) + a(CHEBI:amyloid-beta) association bp(GO:"choline transport") - pmid:25514383 + pubmed:19293145 - a(CHEBI:"amyloid-beta") increases act(a(CHEBI:acetylcholine)) + a(CHEBI:amyloid-beta) increases act(p(HGNC:CHRNA7, var("p.Leu250Thr"))) - pmid:17009926 + pubmed:19293145 - a(CHEBI:"amyloid-beta") decreases act(p(FPLX:CHRM)) + a(CHEBI:amyloid-beta) increases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) - pmid:26813123 + pubmed:19293145 - a(CHEBI:"amyloid-beta") increases a(HBP:"amyloid-beta fibrils") + a(CHEBI:amyloid-beta) decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) - pmid:26813123 + pubmed:19293145 - act(a(CHEBI:"amyloid-beta")) association act(p(HGNC:CHRM1)) + a(CHEBI:amyloid-beta) decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) - pmid:24590577 + pubmed:19293145 - a(CHEBI:"amyloid-beta") decreases act(p(HGNC:CHRM1)) + a(CHEBI:amyloid-beta) causesNoChange act(complex(p(HGNC:CHRNA3), p(HGNC:CHRNB4))) - pmid:24590577 + pubmed:19293145 - a(CHEBI:"amyloid-beta") decreases complex(p(FPLX:"G_protein"), p(HGNC:CHRM1)) + a(CHEBI:amyloid-beta) decreases act(complex(p(HGNC:CHRNA2), p(HGNC:CHRNB2))) - pmid:25514383 + pubmed:19293145 - a(CHEBI:"amyloid-beta") increases act(a(HBP:"beta-2-containing nAChR")) + a(CHEBI:amyloid-beta) decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNA5), p(HGNC:CHRNB2))) - pmid:25514383 + pubmed:19293145 - act(a(CHEBI:"amyloid-beta")) negativeCorrelation a(HBP:"alpha-7 beta-2 nAChR") + a(CHEBI:amyloid-beta) decreases act(p(HGNC:CHRNA7, var("?"))) - pmid:25514383 + pubmed:19293145 - a(CHEBI:"amyloid-beta") regulates act(p(FPLX:CHRN)) + a(CHEBI:amyloid-beta) decreases act(a(CHEBI:nicotine)) - pmid:25514383 + pubmed:19293145 - a(CHEBI:"amyloid-beta") decreases act(p(FPLX:CHRN)) + a(CHEBI:amyloid-beta) increases p(HGNC:CHRNA3) - pmid:25514383 + pubmed:19293145 - a(CHEBI:"amyloid-beta") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + a(CHEBI:amyloid-beta) decreases p(RGD:Chrna4) - pmid:25514383 + pubmed:19293145 - a(CHEBI:"amyloid-beta") decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + a(CHEBI:amyloid-beta) decreases p(RGD:Chrna7) - pmid:25514383 + pubmed:19293145 - a(CHEBI:"amyloid-beta") decreases bp(GO:"neuron cellular homeostasis") + a(CHEBI:amyloid-beta) increases r(RGD:Chrna7) - pmid:25514383 + pubmed:19293145 - a(CHEBI:"amyloid-beta") decreases a(GO:synapse) + a(CHEBI:amyloid-beta) increases p(MGI:Chat) + + - pmid:22908190 + pubmed:19293145 - a(CHEBI:"amyloid-beta") decreases act(a(GO:synapse)) + a(CHEBI:amyloid-beta) increases r(MGI:Chrna3) - pmid:26010758 + pubmed:17009926 - a(CHEBI:"amyloid-beta") increases bp(GO:locomotion) + a(CHEBI:amyloid-beta) decreases a(CHEBI:acetylcholine) - pmid:26010758 + pubmed:17009926 - a(CHEBI:"amyloid-beta") decreases path(MESH:Anxiety) + a(CHEBI:amyloid-beta) decreases tloc(a(CHEBI:acetylcholine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:26010758 + pubmed:25514383 - a(CHEBI:"amyloid-beta") decreases path(MESH:"Interpersonal Relations") + a(CHEBI:amyloid-beta) increases act(a(CHEBI:acetylcholine)) - pmid:26010758 + pubmed:17009926 - a(CHEBI:"amyloid-beta") increases p(HGNC:AIF1) + a(CHEBI:amyloid-beta) decreases act(p(FPLX:CHRM)) - pmid:26010758 + pubmed:22530628 - a(CHEBI:"amyloid-beta") increases p(HGNC:PTPRC) + a(CHEBI:amyloid-beta) positiveCorrelation path(MESH:"Memory Disorders") + + - pmid:26010758 + pubmed:22530628 - a(CHEBI:"amyloid-beta") increases p(HGNC:STAT3, pmod(Ph)) + a(CHEBI:amyloid-beta) positiveCorrelation path(DOID:dementia) - pmid:26010758 + pubmed:26813123 - a(CHEBI:"amyloid-beta") increases r(HGNC:BACE1) + a(CHEBI:amyloid-beta) increases a(CONSO:"amyloid-beta fibrils") - pmid:12428809 + pubmed:26813123 - a(CHEBI:"amyloid-beta") association bp(GO:"axonal transport") + act(a(CHEBI:amyloid-beta)) association act(p(HGNC:CHRM1)) - pmid:21722302 + pubmed:24590577 - a(CHEBI:"amyloid-beta") association p(HGNC:XBP1) + a(CHEBI:amyloid-beta) decreases act(p(HGNC:CHRM1)) + + + + + + + + + + - pmid:21722302 + pubmed:31248781 - a(CHEBI:"amyloid-beta") decreases tloc(a(CHEBI:"calcium cation"), fromLoc(GO:"endoplasmic reticulum"), toLoc(GO:cytoplasm)) + a(CHEBI:amyloid-beta) regulates p(MESH:"Receptors, Islet Amyloid Polypeptide") - pmid:29758300 + pubmed:31248781 - a(CHEBI:"amyloid-beta") positiveCorrelation act(complex(GO:"TOR complex")) + act(a(CHEBI:amyloid-beta)) increases path(MESH:"Oxidative Stress") - pmid:29758300 + pubmed:24590577 - a(CHEBI:"amyloid-beta") negativeCorrelation bp(GO:macroautophagy) + a(CHEBI:amyloid-beta) decreases complex(p(FPLX:"G_protein"), p(HGNC:CHRM1)) + + - pmid:29758300 + pubmed:26979166 - a(CHEBI:"amyloid-beta") increases p(HGNC:TARDBP, pmod(Ph)) + a(CHEBI:amyloid-beta, loc(GO:"extracellular space")) increases bp(GO:"microglial cell activation") - pmid:29758300 + pubmed:30988501 - a(CHEBI:"amyloid-beta") increases p(HGNC:TARDBP) + a(CHEBI:amyloid-beta, loc(GO:"extracellular matrix")) increases bp(GO:"microglial cell activation") + + - pmid:29758300 + pubmed:25514383 - a(CHEBI:"amyloid-beta") positiveCorrelation p(HGNC:PICALM) + a(CHEBI:amyloid-beta) increases act(p(CONSO:"beta-2-containing nAChR")) - pmid:29758300 + pubmed:25514383 - a(CHEBI:"amyloid-beta") negativeCorrelation p(HGNC:SORL1) + act(a(CHEBI:amyloid-beta)) negativeCorrelation p(CONSO:"alpha-7 beta-2 nAChR") + + + + + + + + - pmid:14556719 + pubmed:25514383 - a(CHEBI:"amyloid-beta") decreases act(complex(GO:"proteasome complex")) + a(CHEBI:amyloid-beta) regulates act(p(FPLX:CHRN)) - pmid:22908190 + pubmed:25514383 - a(CHEBI:"amyloid-beta") negativeCorrelation act(complex(GO:"proteasome complex")) + a(CHEBI:amyloid-beta) decreases act(p(FPLX:CHRN)) + + - pmid:14556719 + pubmed:25514383 - a(CHEBI:"amyloid-beta") decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + a(CHEBI:amyloid-beta) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) - pmid:22908190 + pubmed:25514383 - a(CHEBI:"amyloid-beta") positiveCorrelation bp(GO:endocytosis) + a(CHEBI:amyloid-beta) decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + + - pmid:22908190 + pubmed:25514383 - a(CHEBI:"amyloid-beta") positiveCorrelation bp(GO:endocytosis) + a(CHEBI:amyloid-beta) decreases bp(GO:"neuron cellular homeostasis") - pmid:22908190 + pubmed:25514383 - a(CHEBI:"amyloid-beta") positiveCorrelation a(CHEBI:"amyloid-beta polypeptide 42") + a(CHEBI:amyloid-beta) decreases a(GO:synapse) - pmid:25784053 + pubmed:22908190 - a(CHEBI:"amyloid-beta") decreases act(p(FPLX:Proteasome)) + a(CHEBI:amyloid-beta) decreases act(a(GO:synapse)) + + + + + + - pmid:24027553 + pubmed:26010758 - a(CHEBI:"amyloid-beta") increases p(HGNC:MAPT, frag("?", "17kD")) + a(CHEBI:amyloid-beta) increases bp(GO:locomotion) - pmid:24027553 + pubmed:26010758 - a(CHEBI:"amyloid-beta") increases p(HGNC:MAPT, frag("?", "35kD")) + a(CHEBI:amyloid-beta) decreases path(MESH:Anxiety) - pmid:24027553 + pubmed:26010758 - a(CHEBI:"amyloid-beta") increases p(HGNC:MAPT, frag("?", "24kD")) + a(CHEBI:amyloid-beta) association path(MESH:"Interpersonal Relations") - pmid:24027553 + pubmed:26010758 - a(CHEBI:"amyloid-beta") increases p(HBP:"Tau C3") + a(CHEBI:amyloid-beta) increases p(HGNC:AIF1) - pmid:30126037 + pubmed:26010758 - a(CHEBI:"amyloid-beta") causesNoChange p(MGI:Cdkn2a) + a(CHEBI:amyloid-beta) increases p(HGNC:PTPRC) - pmid:30985105 + pubmed:26010758 - a(CHEBI:"amyloid-beta") negativeCorrelation p(HGNC:APP, pmod(HBP:"O-GlcNAcylation")) + a(CHEBI:amyloid-beta) increases p(HGNC:STAT3, pmod(go:0006468 ! "protein phosphorylation")) - pmid:30985105 + pubmed:26010758 - a(CHEBI:"amyloid-beta") association bp(GO:cognition) + a(CHEBI:amyloid-beta) increases r(HGNC:BACE1) - pmid:26195256 + pubmed:30688256 - a(CHEBI:"amyloid-beta") positiveCorrelation p(HBP:"APOE e4") + a(CHEBI:amyloid-beta, loc(MESH:Mitochondria)) increases a(CHEBI:"reactive oxygen species") - pmid:26631930 + pubmed:16566606 - a(CHEBI:"amyloid-beta") increases path(HBP:Excitotoxicity) + a(CHEBI:amyloid-beta) increases a(CHEBI:"reactive oxygen species") - pmid:26631930 + pubmed:30688256 - a(CHEBI:"amyloid-beta") increases path(HBP:Excitotoxicity) + a(CHEBI:amyloid-beta, loc(MESH:Mitochondria)) decreases act(a(MESH:Mitochondria)) - pmid:29626319 + pubmed:30688256 - a(CHEBI:"amyloid-beta") increases bp(GO:"response to oxidative stress") + a(CHEBI:amyloid-beta, loc(MESH:Mitochondria)) decreases a(MESH:Neurons) - pmid:29626319 + pubmed:12428809 - a(CHEBI:"amyloid-beta") increases bp(HBP:"mitochondrial dysfunction") + a(CHEBI:amyloid-beta) association bp(GO:"axonal transport") - pmid:29626319 + pubmed:21722302 - a(CHEBI:"amyloid-beta") positiveCorrelation bp(GO:aging) + a(CHEBI:amyloid-beta) association p(HGNC:XBP1) - pmid:29421605 + pubmed:21722302 - a(CHEBI:"amyloid-beta") positiveCorrelation bp(GO:aging) + a(CHEBI:amyloid-beta) decreases tloc(a(CHEBI:"calcium cation"), fromLoc(GO:"endoplasmic reticulum"), toLoc(GO:cytoplasm)) - pmid:29626319 + pubmed:29758300 - a(CHEBI:"amyloid-beta") positiveCorrelation path(MESH:"Diabetes Mellitus") + a(CHEBI:amyloid-beta) positiveCorrelation act(complex(GO:"TOR complex")) - pmid:29626319 + pubmed:29758300 - a(CHEBI:"amyloid-beta") increases act(p(HGNC:MMP2)) + a(CHEBI:amyloid-beta) negativeCorrelation bp(GO:macroautophagy) - pmid:29626319 + pubmed:29758300 - a(CHEBI:"amyloid-beta") increases act(p(HGNC:MMP3)) + a(CHEBI:amyloid-beta) increases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation")) - pmid:29626319 + pubmed:29758300 - a(CHEBI:"amyloid-beta") increases act(p(HGNC:MMP9)) + a(CHEBI:amyloid-beta) increases p(HGNC:TARDBP) - pmid:29626319 + pubmed:29758300 - a(CHEBI:"amyloid-beta") decreases a(MESH:"Cerebrospinal Fluid") + a(CHEBI:amyloid-beta) association complex(GO:"gamma-secretase complex") - pmid:29626319 + pubmed:29758300 - deg(a(CHEBI:"amyloid-beta")) association p(HGNC:AQP4) + a(CHEBI:amyloid-beta) positiveCorrelation p(HGNC:PICALM) - pmid:19251756 + pubmed:29758300 - a(CHEBI:"amyloid-beta") increases bp(GO:"response to nitrosative stress") + a(CHEBI:amyloid-beta) negativeCorrelation p(HGNC:SORL1) + + - pmid:19251756 + pubmed:14556719 - a(CHEBI:"amyloid-beta") positiveCorrelation complex(p(HGNC:MAPT), p(INTERPRO:"Triosephosphate isomerase", pmod(NO))) + a(CHEBI:amyloid-beta) decreases act(complex(GO:"proteasome complex")) - pmid:16566606 + pubmed:22908190 - a(CHEBI:"amyloid-beta") increases a(CHEBI:"reactive nitrogen species") + a(CHEBI:amyloid-beta) negativeCorrelation act(complex(GO:"proteasome complex")) - pmid:16566606 + pubmed:14556719 - a(CHEBI:"amyloid-beta") increases a(CHEBI:"reactive oxygen species") + a(CHEBI:amyloid-beta) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:29221819 + pubmed:22908190 - a(CHEBI:"amyloid-beta") positiveCorrelation p(MGI:Dyrk1a) + a(CHEBI:amyloid-beta) positiveCorrelation bp(GO:endocytosis) - pmid:28877763 + pubmed:22908190 - a(CHEBI:"amyloid-beta") increases act(p(HGNC:SYK)) + a(CHEBI:amyloid-beta) positiveCorrelation bp(GO:endocytosis) - pmid:28877763 + pubmed:22908190 - a(CHEBI:"amyloid-beta") increases a(HBP:"dystrophic neurite") + tloc(a(CHEBI:amyloid-beta), fromLoc(GO:cytosol), toLoc(GO:autolysosome)) positiveCorrelation a(CHEBI:"amyloid-beta polypeptide 42") - pmid:26118667 + pubmed:25784053 - a(CHEBI:"amyloid-beta", loc(MESH:"Intracellular Space")) increases act(p(FPLX:CAPN)) + a(CHEBI:amyloid-beta) decreases act(p(FPLX:Proteasome)) - pmid:22156579 + pubmed:24027553 - a(CHEBI:"amyloid-beta") increases p(RGD:Mapt, pmod(Ph, Ser, 262)) + a(CHEBI:amyloid-beta) increases p(HGNC:MAPT, frag("?", "17kD")) - pmid:22156579 + pubmed:24027553 - a(CHEBI:"amyloid-beta") increases p(RGD:Mapt, pmod(Ph, Ser, 356)) + a(CHEBI:amyloid-beta) increases p(HGNC:MAPT, frag("?", "35kD")) - pmid:22156579 + pubmed:24027553 - a(CHEBI:"amyloid-beta") increases act(p(HGNC:MARK4)) + a(CHEBI:amyloid-beta) increases p(HGNC:MAPT, frag("?", "24kD")) - pmid:22156579 + pubmed:24027553 - a(CHEBI:"amyloid-beta") increases p(HBP:"Tau epitope, PHF1", pmod(Ph)) + a(CHEBI:amyloid-beta) increases p(CONSO:"Tau C3") - pmid:25672970 + pubmed:30126037 - a(CHEBI:"amyloid-beta") increases bp(GO:"neuroinflammatory response") + a(CHEBI:amyloid-beta) causesNoChange p(MGI:Cdkn2a) - pmid:28855586 + pubmed:30985105 - act(a(CHEBI:"amyloid-beta")) negativeCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 163), pmod(Ac, Lys, 280), pmod(Ac, Lys, 281), pmod(Ac, Lys, 369)) + a(CHEBI:amyloid-beta) negativeCorrelation p(HGNC:APP, pmod(CONSO:O-GlcNAcylation)) - pmid:25378699 + pubmed:30985105 - a(CHEBI:"amyloid-beta") increases p(RGD:Mapt, pmod(HBP:hyperphosphorylation), pmod(Sumo)) + a(CHEBI:amyloid-beta) association bp(GO:cognition) - pmid:28500862 + pubmed:26195256 - a(CHEBI:"amyloid-beta") positiveCorrelation p(HBP:"Tau aggregates") + a(CHEBI:amyloid-beta) positiveCorrelation g(CONSO:"APOE e4") - pmid:18675254 + pubmed:26631930 - a(CHEBI:"amyloid-beta") negativeCorrelation p(HGNC:APP, pmod(Sumo, Lys, 587)) + a(CHEBI:amyloid-beta) increases path(CONSO:Excitotoxicity) - pmid:18675254 + pubmed:26631930 - a(CHEBI:"amyloid-beta") negativeCorrelation p(HGNC:APP, pmod(Sumo, Lys, 595)) + a(CHEBI:amyloid-beta) increases path(CONSO:Excitotoxicity) - pmid:28019679 + pubmed:29626319 - a(CHEBI:"amyloid-beta") increases bp(GO:"innate immune response") + a(CHEBI:amyloid-beta) increases bp(GO:"response to oxidative stress") - pmid:28019679 + pubmed:29626319 - a(CHEBI:"amyloid-beta") increases act(complex(GO:"NLRP3 inflammasome complex")) + a(CHEBI:amyloid-beta) positiveCorrelation bp(GO:aging) - pmid:23702978 + pubmed:29421605 - a(CHEBI:"amyloid-beta") increases act(complex(GO:"NLRP3 inflammasome complex")) + a(CHEBI:amyloid-beta) positiveCorrelation bp(GO:aging) - pmid:28019679 + pubmed:29626319 - a(CHEBI:"amyloid-beta") increases a(CHEBI:"nitric oxide") + a(CHEBI:amyloid-beta) positiveCorrelation path(MESH:"Diabetes Mellitus") - pmid:28019679 + pubmed:29626319 - a(CHEBI:"amyloid-beta") increases act(complex(GO:"NLRP1 inflammasome complex")) + a(CHEBI:amyloid-beta) increases act(p(HGNC:MMP2)) - pmid:28019679 + pubmed:29626319 - a(CHEBI:"amyloid-beta") increases act(p(HGNC:CASP1)) + a(CHEBI:amyloid-beta) increases act(p(HGNC:MMP3)) - pmid:23702978 + pubmed:29626319 - a(CHEBI:"amyloid-beta") increases act(p(HGNC:NLRP3)) + a(CHEBI:amyloid-beta) increases act(p(HGNC:MMP9)) - pmid:27314526 + pubmed:29626319 - a(CHEBI:"amyloid-beta") association p(HGNC:NLRP3) + a(CHEBI:amyloid-beta) decreases a(MESH:"Cerebrospinal Fluid") + + - pmid:23702978 + pubmed:29626319 - a(CHEBI:"amyloid-beta") increases act(p(FPLX:TLR)) + deg(a(CHEBI:amyloid-beta)) association p(HGNC:AQP4) + + - pmid:24561250 + pubmed:19251756 - a(CHEBI:"amyloid-beta") increases act(complex(GO:"inflammasome complex")) + a(CHEBI:amyloid-beta) increases bp(GO:"response to nitrosative stress") - pmid:24561250 + pubmed:19251756 - a(CHEBI:"amyloid-beta") increases bp(GO:phagocytosis) + a(CHEBI:amyloid-beta) positiveCorrelation complex(p(HGNC:MAPT), p(INTERPRO:"Triosephosphate isomerase", pmod(go:0017014 ! "protein nitrosylation"))) - pmid:24561250 + pubmed:16566606 - a(CHEBI:"amyloid-beta") decreases a(GO:lysosome) + a(CHEBI:amyloid-beta) increases a(CHEBI:"reactive nitrogen species") - pmid:30046111 + pubmed:29221819 - bp(GO:phagocytosis) regulates deg(a(CHEBI:"amyloid-beta")) + a(CHEBI:amyloid-beta) positiveCorrelation p(MGI:Dyrk1a) - pmid:29626319 + pubmed:28877763 - bp(GO:phagocytosis) increases deg(a(CHEBI:"amyloid-beta")) + a(CHEBI:amyloid-beta) increases act(p(HGNC:SYK)) - pmid:29626319 + pubmed:28877763 - bp(GO:phagocytosis) increases deg(a(CHEBI:"amyloid-beta")) + a(CHEBI:amyloid-beta) increases a(CONSO:"dystrophic neurite") - pmid:29626319 + pubmed:26118667 - bp(GO:phagocytosis) increases deg(a(CHEBI:"amyloid-beta")) + a(CHEBI:amyloid-beta, loc(MESH:"Intracellular Space")) increases act(p(FPLX:CAPN)) - pmid:29626319 + pubmed:22156579 - bp(GO:phagocytosis) association p(HGNC:TREM2) + a(CHEBI:amyloid-beta) increases p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) - pmid:29626319 + pubmed:22156579 - bp(GO:phagocytosis) association p(HGNC:ABCA7) + a(CHEBI:amyloid-beta) increases p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) - pmid:29626319 + pubmed:22156579 - bp(GO:phagocytosis) association p(HGNC:CD33) + a(CHEBI:amyloid-beta) increases act(p(HGNC:MARK4)) - pmid:29626319 + pubmed:22156579 - bp(GO:phagocytosis) increases deg(a(CHEBI:"amyloid-beta polypeptide 42")) + a(CHEBI:amyloid-beta) increases p(CONSO:"Tau epitope, PHF1", pmod(go:0006468 ! "protein phosphorylation")) - pmid:29626319 + pubmed:25672970 - bp(GO:phagocytosis) decreases p(HGNC:MAPT) + a(CHEBI:amyloid-beta) increases bp(GO:"neuroinflammatory response") - pmid:24561250 + pubmed:28855586 - bp(GO:phagocytosis) increases act(complex(GO:"NLRP3 inflammasome complex")) + act(a(CHEBI:amyloid-beta)) negativeCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 163), pmod(go:0006473 ! "protein acetylation", Lys, 280), pmod(go:0006473 ! "protein acetylation", Lys, 281), pmod(go:0006473 ! "protein acetylation", Lys, 369)) - pmid:30046111 + pubmed:25378699 - a(MESH:Microglia) regulates deg(a(CHEBI:"amyloid-beta")) + a(CHEBI:amyloid-beta) increases p(RGD:Mapt, pmod(CONSO:hyperphosphorylation), pmod(go:0016925 ! "protein sumoylation")) - pmid:26195256 + pubmed:18675254 - a(MESH:Microglia) decreases a(CHEBI:"amyloid-beta", loc(MESH:"Extracellular Fluid")) + a(CHEBI:amyloid-beta) negativeCorrelation p(HGNC:APP, pmod(go:0016925 ! "protein sumoylation", Lys, 587)) - pmid:26195256 + pubmed:18675254 - act(a(MESH:Microglia)) decreases a(CHEBI:"amyloid-beta") + a(CHEBI:amyloid-beta) negativeCorrelation p(HGNC:APP, pmod(go:0016925 ! "protein sumoylation", Lys, 595)) - pmid:28745240 + pubmed:28019679 - act(a(MESH:Microglia)) increases p(HGNC:TNF) + a(CHEBI:amyloid-beta) increases bp(GO:"innate immune response") - pmid:28745240 + pubmed:28019679 - act(a(MESH:Microglia)) increases p(HGNC:IL1B) + a(CHEBI:amyloid-beta) increases act(complex(GO:"NLRP3 inflammasome complex")) - pmid:28745240 + pubmed:23702978 - act(a(MESH:Microglia)) increases p(HGNC:IL6) + a(CHEBI:amyloid-beta) increases act(complex(GO:"NLRP3 inflammasome complex")) + + - pmid:28745240 + pubmed:28019679 - act(a(MESH:Microglia)) increases p(HGNC:CXCL8) + a(CHEBI:amyloid-beta) increases a(CHEBI:"nitric oxide") + + - pmid:28745240 + pubmed:28019679 - act(a(MESH:Microglia)) increases bp(GO:"neuron death") + a(CHEBI:amyloid-beta) increases act(complex(GO:"NLRP1 inflammasome complex")) - pmid:25652642 + pubmed:28019679 - act(a(MESH:Microglia)) positiveCorrelation a(CHEBI:"amyloid-beta polypeptide 42") + a(CHEBI:amyloid-beta) increases act(p(HGNC:CASP1)) - pmid:23178521 + pubmed:23702978 - a(MESH:Microglia) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") + a(CHEBI:amyloid-beta) increases act(p(HGNC:NLRP3)) - pmid:23383175 + pubmed:27314526 - a(MESH:Microglia) positiveCorrelation a(MESH:Astrocytes) + a(CHEBI:amyloid-beta) association p(HGNC:NLRP3) - pmid:23383175 + pubmed:23702978 - a(MESH:Microglia) negativeCorrelation a(GO:"myelin sheath") + a(CHEBI:amyloid-beta) increases act(p(FPLX:TLR)) - pmid:29202785 + pubmed:24561250 - act(a(MESH:Microglia)) negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) + a(CHEBI:amyloid-beta) increases act(complex(GO:"inflammasome complex")) - pmid:29202785 + pubmed:24561250 - act(a(MESH:Microglia)) positiveCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) + a(CHEBI:amyloid-beta) increases bp(GO:phagocytosis) - pmid:28528849 + pubmed:24561250 - a(MESH:Microglia) regulates act(p(HBP:"Tau oligomers", var("p.Lys280del"))) + a(CHEBI:amyloid-beta) decreases a(GO:lysosome) - pmid:26195256 + pubmed:30988501 - act(a(MESH:Microglia)) increases a(MESH:Cytokines) + a(CHEBI:amyloid-beta, loc(GO:intracellular)) biomarkerFor path(DOID:"Alzheimer's disease") - pmid:29626319 + pubmed:30046111 - a(MESH:Microglia) increases bp(GO:"immune response") + bp(GO:phagocytosis) regulates deg(a(CHEBI:amyloid-beta)) - pmid:29626319 + pubmed:29626319 - act(a(MESH:Microglia)) increases bp(GO:"cytokine production involved in inflammatory response") + bp(GO:phagocytosis) increases deg(a(CHEBI:amyloid-beta)) - pmid:29626319 + pubmed:29626319 - act(a(MESH:Microglia)) increases bp(GO:"inflammatory response") + bp(GO:phagocytosis) increases deg(a(CHEBI:amyloid-beta)) - pmid:29626319 + pubmed:29626319 - act(a(MESH:Microglia)) increases bp(HBP:Neurodegeneration) + bp(GO:phagocytosis) increases deg(a(CHEBI:amyloid-beta)) - pmid:29626319 + pubmed:30967783 - act(a(MESH:Microglia)) increases bp(GO:phagocytosis) + bp(GO:phagocytosis) increases deg(a(NCIT:C120869)) - pmid:29626319 + pubmed:29626319 - a(MESH:Microglia) increases bp(GO:phagocytosis) + bp(GO:phagocytosis) association p(HGNC:TREM2) - pmid:29238289 + pubmed:29626319 - a(MESH:Microglia) increases sec(p(HGNC:MAPT)) + bp(GO:phagocytosis) association p(HGNC:ABCA7) - pmid:27314526 + pubmed:29626319 - a(MESH:Microglia) increases p(HGNC:NLRP3) + bp(GO:phagocytosis) association p(HGNC:CD33) - pmid:27314526 + pubmed:29626319 - a(MESH:Microglia) increases p(HGNC:P2RX7) + bp(GO:phagocytosis) increases deg(a(CHEBI:"amyloid-beta polypeptide 42")) - pmid:27314526 + pubmed:29626319 - a(MESH:Microglia) increases p(HGNC:TLR4) + bp(GO:phagocytosis) decreases p(HGNC:MAPT) - pmid:30046111 + pubmed:24561250 - a(MESH:Monocytes) regulates deg(a(CHEBI:"amyloid-beta")) + bp(GO:phagocytosis) increases act(complex(GO:"NLRP3 inflammasome complex")) - pmid:29626319 + pubmed:30988501 - a(MESH:Monocytes) increases deg(a(CHEBI:"amyloid-beta")) + bp(GO:phagocytosis) increases bp(GO:"activation of innate immune response") - pmid:29626319 + pubmed:30046111 - a(MESH:Monocytes) increases deg(a(CHEBI:"amyloid-beta")) + a(MESH:Microglia) regulates deg(a(CHEBI:amyloid-beta)) - pmid:30046111 + pubmed:26195256 - a(MESH:Macrophages) regulates deg(a(CHEBI:"amyloid-beta")) + a(MESH:Microglia) decreases a(CHEBI:amyloid-beta, loc(MESH:"Extracellular Fluid")) - pmid:30046111 + pubmed:26195256 - a(MESH:Macrophages) association a(CHEBI:"amyloid-beta") + act(a(MESH:Microglia)) decreases a(CHEBI:amyloid-beta) - pmid:26195256 + pubmed:28745240 - a(MESH:Macrophages) increases deg(a(CHEBI:"amyloid-beta")) + act(a(MESH:Microglia)) increases p(HGNC:TNF) - pmid:30046111 + pubmed:30967783 - a(HBP:HBP00018) positiveCorrelation path(MESH:"Alzheimer Disease") + a(MESH:Microglia) increases p(HGNC:TNF) - pmid:21718217 + pubmed:30988501 - a(HBP:HBP00018) association path(MESH:"Alzheimer Disease") + a(MESH:Microglia) increases tloc(p(HGNC:TNF), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:30046111 + pubmed:28745240 - a(HBP:HBP00018) decreases bp(GO:"neuron cellular homeostasis") + act(a(MESH:Microglia)) increases p(HGNC:IL1B) - pmid:30046111 + pubmed:30967783 - a(HBP:HBP00018) increases path(MESH:"Problem Behavior") + a(MESH:Microglia) increases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:29196815 + pubmed:28745240 - a(HBP:HBP00018) causesNoChange bp(GO:"neuron death") + act(a(MESH:Microglia)) increases p(HGNC:IL6) - pmid:29196815 + pubmed:30967783 - a(HBP:HBP00018) causesNoChange bp(GO:"astrocyte activation") + a(MESH:Microglia) increases p(HGNC:IL6) - pmid:22122372 + pubmed:30967783 - a(HBP:HBP00018) association a(MESH:"Amyloid beta-Peptides") + a(MESH:Microglia) increases tloc(p(HGNC:IL6), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:22122372 + pubmed:28745240 - a(HBP:HBP00018) increases path(MESH:"Plaque, Amyloid") + act(a(MESH:Microglia)) increases p(HGNC:CXCL8) - pmid:30046111 + pubmed:28745240 - path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:HBP00018) + act(a(MESH:Microglia)) increases bp(GO:"neuron death") - pmid:21718217 + pubmed:25652642 - path(MESH:"Alzheimer Disease") association a(HBP:HBP00018) + act(a(MESH:Microglia)) positiveCorrelation a(CHEBI:"amyloid-beta polypeptide 42") - pmid:22040696 + pubmed:27794524 - path(MESH:"Alzheimer Disease") increases a(HBP:HBP00018) + a(MESH:Microglia) directlyIncreases tloc(a(CHEBI:"reactive oxygen species"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:30046111 + pubmed:27794524 - path(MESH:"Alzheimer Disease") association act(a(MESH:"Lymphatic Vessels")) + a(MESH:Microglia) directlyIncreases a(CHEBI:"reactive oxygen species") - pmid:30046111 + pubmed:27794524 - path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:"amyloid-beta") + a(MESH:Microglia) directlyIncreases tloc(a(CHEBI:"reactive nitrogen species"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:30046111 + pubmed:27794524 - path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:"amyloid-beta") + a(MESH:Microglia) directlyIncreases a(CHEBI:"reactive nitrogen species") - pmid:30046111 + pubmed:27794524 - path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:"amyloid-beta") + a(MESH:Microglia) directlyIncreases a(CHEBI:"nitric oxide") - pmid:29196815 + pubmed:27794524 - path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:"amyloid-beta") + a(MESH:Microglia) association a(PUBCHEM:54677946) - pmid:29196815 + pubmed:26445701 - path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:"amyloid-beta") + act(a(MESH:Microglia)) increases path(MESH:Inflammation) - pmid:19293145 + pubmed:30967783 - path(MESH:"Alzheimer Disease") association sec(a(CHEBI:"amyloid-beta")) + a(MESH:Microglia) decreases path(MESH:Inflammation) + + - pmid:19293145 + pubmed:30967783 - path(MESH:"Alzheimer Disease") association a(CHEBI:"amyloid-beta") + a(MESH:Microglia) regulates bp(MESH:Homeostasis) - pmid:25514383 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:"amyloid-beta") + a(MESH:Microglia) increases complex(p(HGNC:CX3CL1), p(HGNC:CX3CR1)) - pmid:14556719 + pubmed:30967783 - path(MESH:"Alzheimer Disease") association a(CHEBI:"amyloid-beta") + a(MESH:Microglia) increases bp(MESH:"Neuronal Plasticity") - pmid:26195256 + pubmed:30967783 - path(MESH:"Alzheimer Disease") decreases deg(a(CHEBI:"amyloid-beta")) + a(MESH:Microglia) increases bp(MESH:"Neuronal Plasticity") - pmid:29626319 + pubmed:30967783 - path(MESH:"Alzheimer Disease") decreases deg(a(CHEBI:"amyloid-beta")) + a(MESH:Microglia) increases bp(MESH:"Neuronal Plasticity") - pmid:29626319 + pubmed:30967783 - path(MESH:"Alzheimer Disease") increases a(CHEBI:"amyloid-beta") + a(MESH:Microglia) decreases bp(MESH:"Neuronal Plasticity") - pmid:29980653 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:"amyloid-beta") + a(MESH:Microglia) increases bp(GO:"generation of neurons") - pmid:30663117 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation r(HGNC:BACE1, loc(GO:cytoplasm)) + a(MESH:Microglia) increases p(HGNC:IGF1) - pmid:30663117 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation r(HGNC:"BACE1-AS") + a(MESH:Microglia) increases bp(GO:"learning or memory") - pmid:30663117 + pubmed:30988501 - path(MESH:"Alzheimer Disease") association g(HGNC:MIR384) + a(MESH:Microglia) increases bp(GO:"learning or memory") - pmid:30663117 + pubmed:30967783 - path(MESH:"Alzheimer Disease") association g(HGNC:"MIR153-1") + a(MESH:Microglia) increases a(GO:synapse) - pmid:30663117 + pubmed:30967783 - path(MESH:"Alzheimer Disease") association g(HGNC:"MIR101-1") + a(MESH:Microglia) increases p(HGNC:BDNF) + + - pmid:30663117 + pubmed:30967783 - path(MESH:"Alzheimer Disease") association g(HGNC:"MIR9-1") + a(MESH:Microglia) increases bp(GO:"apoptotic cell clearance") - pmid:30663117 + pubmed:30967783 - path(MESH:"Alzheimer Disease") decreases g(HGNC:"MIR9-1") + a(MESH:Microglia) increases deg(p(MESH:Proteins, pmod(CONSO:misfolded))) - pmid:21329555 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:RELA) + a(MESH:Microglia) decreases p(MESH:Proteins, pmod(CONSO:misfolded)) - pmid:25652642 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:RELA) + a(MESH:Microglia) increases p(HGNC:IFNG) - pmid:21329555 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:BACE1) + a(MESH:Microglia) increases p(MESH:Interleukin-23) - pmid:10656250 + pubmed:30967783 - path(MESH:"Alzheimer Disease") increases p(HGNC:BACE1) + a(MESH:Microglia) increases p(HGNC:NOS2) - pmid:21329555 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:Inflammation) + a(MESH:Microglia) increases p(HGNC:CCL4) - pmid:27288790 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:Inflammation) + a(MESH:Microglia) increases p(HGNC:CCL5) - pmid:24027553 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:Inflammation) + a(MESH:Microglia) increases tloc(p(HGNC:CCL5), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:28745240 + pubmed:30967783 - path(MESH:"Alzheimer Disease") association p(HGNC:IL6) + a(MESH:Microglia) increases p(HGNC:CCL8) - pmid:25652642 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL6) + a(MESH:Microglia) increases p(HGNC:CXCL2) - pmid:28745240 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:TNF) + a(MESH:Microglia) increases p(HGNC:PF4) - pmid:27288790 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:TNF) + a(MESH:Microglia) increases p(HGNC:CXCL9) - pmid:25652642 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:TNF) + a(MESH:Microglia) isA a(MESH:"Antigen-Presenting Cells") - pmid:29179999 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation p(FPLX:NFkappaB) + a(MESH:Microglia) isA a(MESH:"Antigen-Presenting Cells") - pmid:27288790 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation act(p(FPLX:NFkappaB)) + a(MESH:Microglia) increases bp(MESH:"Adaptive Immunity") - pmid:27288790 + pubmed:30967783 - path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"regulation of synaptic plasticity") + a(MESH:Microglia) increases p(HGNC:IL4) - pmid:27288790 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:"reactive oxygen species") + a(MESH:Microglia) increases p(HGNC:IL10) - pmid:27288790 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL1B) + a(MESH:Microglia) increases p(HGNC:IL13) - pmid:25652642 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL1B) + a(MESH:Microglia) increases p(HGNC:TGFB1) - pmid:24561250 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL1B) + a(MESH:Microglia) regulates bp(MESH:Immunity) - pmid:27314526 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL1B) + a(MESH:Microglia) increases bp(GO:"tissue remodeling") - pmid:27288790 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL18) + a(MESH:Microglia) increases bp(GO:angiogenesis) - pmid:24561250 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL18) + a(MESH:Microglia) increases deg(a(MESH:Parasites)) - pmid:27314526 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL18) + a(MESH:Microglia) increases bp(GO:"oligodendrocyte differentiation") - pmid:27314526 + pubmed:30967783 - path(MESH:"Alzheimer Disease") association p(HGNC:IL18) + a(MESH:Microglia) increases bp(MESH:Remyelination) - pmid:27288790 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:CXCL10) + a(MESH:Microglia) increases bp(GO:"brain development") - pmid:27288790 + pubmed:28669544 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:TGFB1) + a(MESH:Microglia) regulates bp(GO:"brain development") - pmid:22020111 + pubmed:30967783 - path(MESH:"Alzheimer Disease") increases p(HGNC:TGFB1) + a(MESH:Microglia) regulates bp(MESH:"Neural Pathways") - pmid:27288790 + pubmed:28669544 - path(MESH:"Alzheimer Disease") positiveCorrelation bp(GO:"MAPK cascade") + a(MESH:Microglia) regulates bp(MESH:"Neural Pathways") - pmid:27288790 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:pentosidine) + a(MESH:Microglia) decreases bp(GO:cognition) + + - pmid:27288790 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:GLAP) + a(MESH:Microglia) increases tloc(p(HGNC:IL18), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:27288790 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:PTGS2) + a(MESH:Microglia) increases tloc(p(HGNC:CCL2), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:22020111 + pubmed:30967783 - path(MESH:"Alzheimer Disease") increases p(HGNC:PTGS2) + a(MESH:Microglia) increases path(DOID:"multiple sclerosis") - pmid:27288790 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation m(MIRBASE:"hsa-mir-146a") + a(MESH:Microglia) increases deg(a(MESH:"Myelin Sheath")) - pmid:27288790 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation m(MIRBASE:"hsa-mir-155") + a(MESH:Microglia) increases bp(GO:phagocytosis) - pmid:25652642 + pubmed:29626319 - path(MESH:"Alzheimer Disease") positiveCorrelation complex(a(GO:"NF-kappaB complex"), p(HGNC:RELA)) + act(a(MESH:Microglia)) increases bp(GO:phagocytosis) - pmid:25652642 + pubmed:29626319 - path(MESH:"Alzheimer Disease") positiveCorrelation act(complex(GO:"NF-kappaB complex")) + a(MESH:Microglia) increases bp(GO:phagocytosis) - pmid:25652642 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation complex(GO:"NF-kappaB complex") + a(MESH:Microglia) increases bp(MESH:Neuroprotection) - pmid:25652642 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation complex(GO:"NF-kappaB complex") + a(MESH:Microglia) increases bp(MESH:Neuroprotection) - pmid:25652642 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation a(MESH:"HLA-DR Antigens") + a(MESH:Microglia) increases a(MESH:Cytokines) - pmid:25652642 + pubmed:26195256 - path(MESH:"Alzheimer Disease") positiveCorrelation m(HGNC:"MIR9-1") + act(a(MESH:Microglia)) increases a(MESH:Cytokines) - pmid:25652642 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation m(HGNC:MIR34A) + a(MESH:Microglia) increases p(HGNC:TREM2) - pmid:25652642 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation m(HGNC:MIR125B1) + act(a(MESH:Microglia)) increases a(MESH:"Glatiramer Acetate") - pmid:25652642 + pubmed:23178521 - path(MESH:"Alzheimer Disease") positiveCorrelation m(HGNC:MIR146A) + a(MESH:Microglia) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") - pmid:25652642 + pubmed:23383175 - path(MESH:"Alzheimer Disease") positiveCorrelation m(HGNC:MIR155) + a(MESH:Microglia) positiveCorrelation a(MESH:Astrocytes) - pmid:25652642 + pubmed:23383175 - path(MESH:"Alzheimer Disease") positiveCorrelation m(HGNC:MIR339) + a(MESH:Microglia) negativeCorrelation a(GO:"myelin sheath") - pmid:30444369 + pubmed:29202785 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:HSD17B10) + act(a(MESH:Microglia)) negativeCorrelation p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) - pmid:30444369 + pubmed:29202785 - path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:PRDX2)) + act(a(MESH:Microglia)) positiveCorrelation p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) - pmid:30444369 + pubmed:28528849 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:PRDX2) + a(MESH:Microglia) regulates act(p(CONSO:"Tau oligomers", var("p.Lys280del"))) - pmid:30444369 + pubmed:29626319 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:CDK5) + act(a(MESH:Microglia)) increases bp(GO:"immune response") - pmid:24653673 + pubmed:29626319 - path(MESH:"Alzheimer Disease") association p(HGNC:CDK5) + act(a(MESH:Microglia)) increases bp(GO:"cytokine production involved in inflammatory response") - pmid:8282104 + pubmed:29626319 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:CDK5) + act(a(MESH:Microglia)) increases bp(GO:"inflammatory response") - pmid:30444369 + pubmed:29238289 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SH3GL2) + a(MESH:Microglia) increases tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:29196815 + pubmed:28669544 - path(MESH:"Alzheimer Disease") isA path(MESH:"Neurodegenerative Diseases") + a(MESH:Microglia) isA bp(MESH:"Immunity, Innate") - pmid:24511233 + pubmed:28669544 - path(MESH:"Alzheimer Disease") isA path(MESH:"Neurodegenerative Diseases") + a(MESH:Microglia) regulates path(MESH:"Neural Pathways") - pmid:24590577 + pubmed:28669544 - path(MESH:"Alzheimer Disease") isA path(MESH:"Neurodegenerative Diseases") + a(MESH:Microglia) regulates bp(GO:"nervous system development") + + - pmid:29980653 + pubmed:28669544 - path(MESH:"Alzheimer Disease") isA path(MESH:"Neurodegenerative Diseases") + a(MESH:Microglia) decreases a(MESH:Synapses) - pmid:29196815 + pubmed:28669544 - path(MESH:"Alzheimer Disease") decreases bp(GO:cognition) + a(MESH:Microglia) directlyDecreases a(MESH:Synapses) - pmid:19126755 + pubmed:28669544 - path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:cognition) + a(MESH:Microglia) decreases path(MESH:"Protein Aggregation, Pathological") - pmid:19293145 + pubmed:28669544 - path(MESH:"Alzheimer Disease") decreases bp(GO:cognition) + a(MESH:Microglia) association path(DOID:"neurodegenerative disease") - pmid:24511233 + pubmed:28669544 - path(MESH:"Alzheimer Disease") association bp(GO:cognition) + a(MESH:Microglia) regulates path(MESH:"Immune System") - pmid:24511233 + pubmed:28669544 - path(MESH:"Alzheimer Disease") decreases bp(GO:cognition) + a(MESH:Microglia) regulates path(MESH:Phagocytosis) - pmid:24590577 + pubmed:28669544 - path(MESH:"Alzheimer Disease") decreases bp(GO:cognition) + a(MESH:Microglia) regulates deg(p(CONSO:"protein aggregates")) + + - pmid:11230871 + pubmed:28669544 - path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:cognition) + a(MESH:Microglia, loc(CONSO:"amyloid-beta oligomers")) increases path(MESH:"Neuronal Plasticity") + + - pmid:19721446 + pubmed:27314526 - path(MESH:"Alzheimer Disease") decreases bp(GO:cognition) + a(MESH:Microglia) increases p(HGNC:NLRP3) - pmid:29196815 + pubmed:27314526 - path(MESH:"Alzheimer Disease") increases bp(GO:"neuron apoptotic process") + a(MESH:Microglia) increases p(HGNC:P2RX7) - pmid:29196815 + pubmed:27314526 - path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Plaque, Amyloid") + a(MESH:Microglia) increases p(HGNC:TLR4) - pmid:19126755 + pubmed:30988501 - path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Plaque, Amyloid") + a(MESH:Microglia) increases bp(MESH:"Immunologic Surveillance") - pmid:19293145 + pubmed:30988501 - path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Plaque, Amyloid") + a(MESH:Microglia) increases bp(GO:"complement-mediated synapse pruning") - pmid:19293145 + pubmed:30988501 - path(MESH:"Alzheimer Disease") association path(MESH:"Plaque, Amyloid") + a(MESH:Microglia) increases bp(GO:"central nervous system development") - pmid:24590577 + pubmed:30988501 - path(MESH:"Alzheimer Disease") association path(MESH:"Plaque, Amyloid") + a(MESH:Microglia) association bp(GO:"synaptic signaling") - pmid:25514383 + pubmed:30988501 - path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Plaque, Amyloid") + a(MESH:Microglia) increases tloc(a(MESH:"Extracellular Vesicles"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:19721446 + pubmed:30988501 - path(MESH:"Alzheimer Disease") increases path(MESH:"Plaque, Amyloid") + a(MESH:Microglia) increases bp(GO:"regulation of neuronal synaptic plasticity") - pmid:14556719 + pubmed:30988501 - path(MESH:"Alzheimer Disease") increases path(MESH:"Plaque, Amyloid") + a(MESH:Microglia) increases bp(GO:"motor learning") - pmid:22817713 + pubmed:30046111 - path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Plaque, Amyloid") + a(MESH:Monocytes) regulates deg(a(CHEBI:amyloid-beta)) - pmid:29196815 + pubmed:29626319 - path(MESH:"Alzheimer Disease") positiveCorrelation a(MESH:"Amyloid beta-Peptides") + a(MESH:Monocytes) increases deg(a(CHEBI:amyloid-beta)) - pmid:22122372 + pubmed:29626319 - path(MESH:"Alzheimer Disease") association a(MESH:"Amyloid beta-Peptides") + a(MESH:Monocytes) increases deg(a(CHEBI:amyloid-beta)) - pmid:29196815 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation a(GO:"neurofibrillary tangle") + a(MESH:Monocytes, loc(MESH:"Blood-Brain Barrier")) directlyIncreases a(MESH:Macrophages, loc(MESH:"Blood-Brain Barrier")) - pmid:28420982 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation a(GO:"neurofibrillary tangle") + a(MESH:Monocytes, loc(GO:"node of Ranvier")) increases path(HP:"CNS demyelination") - pmid:22817713 + pubmed:30967783 - path(MESH:"Alzheimer Disease") association a(GO:"neurofibrillary tangle") + a(MESH:Monocytes) causesNoChange a(MESH:Microglia) - pmid:11089576 + pubmed:30046111 - path(MESH:"Alzheimer Disease") positiveCorrelation a(GO:"neurofibrillary tangle") + a(MESH:Macrophages) regulates deg(a(CHEBI:amyloid-beta)) - pmid:29196815 + pubmed:30046111 - path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:HBP00074) + a(MESH:Macrophages) association a(CHEBI:amyloid-beta) - pmid:29196815 + pubmed:26195256 - path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:HBP00074) + a(MESH:Macrophages) increases deg(a(CHEBI:amyloid-beta)) - pmid:29196815 + pubmed:30962309 - path(MESH:"Alzheimer Disease") negativeCorrelation a(CHEBI:"amyloid-beta polypeptide 42") + a(MESH:Macrophages) increases m(MIRBASE:hsa-mir-302b) - pmid:19293145 + pubmed:27794524 - path(MESH:"Alzheimer Disease") association a(CHEBI:"amyloid-beta polypeptide 42") + a(MESH:Macrophages) directlyIncreases a(CHEBI:"reactive oxygen species") - pmid:29196815 + pubmed:27794524 - path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:HBP00076) + a(MESH:Macrophages) directlyIncreases a(CHEBI:"reactive nitrogen species") - pmid:29196815 + pubmed:27794524 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:NGFR) + a(MESH:Macrophages) directlyIncreases a(CHEBI:"nitric oxide") - pmid:21214928 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation r(HBP:HBP00064) + a(MESH:Macrophages) regulates bp(MESH:Homeostasis) - pmid:21214928 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HBP:HBP00065) + a(MESH:Macrophages) increases bp(GO:"neuroinflammatory response") - pmid:21214928 + pubmed:30967783 - path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:ADAM10) + a(MESH:Macrophages) increases path(DOID:"multiple sclerosis") - pmid:21214928 + pubmed:30967783 - path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:ADAM10)) + a(MESH:Macrophages) increases bp(MESH:Neuroprotection) - pmid:21214928 + pubmed:30967783 - path(MESH:"Alzheimer Disease") negativeCorrelation a(HBP:HBP00067) + a(MESH:Macrophages) increases bp(MESH:Neuroprotection) - pmid:22122372 + pubmed:30967783 - path(MESH:"Alzheimer Disease") association bp(GO:"neurofibrillary tangle assembly") + a(MESH:Macrophages, loc(MESH:Brain)) increases bp(MESH:Neuroprotection) - pmid:22122372 + pubmed:30967783 - path(MESH:"Alzheimer Disease") association bp(GO:"neuron death") + a(MESH:Macrophages) decreases path(MESH:Inflammation) - pmid:19293145 + pubmed:30967783 - path(MESH:"Alzheimer Disease") increases bp(GO:"neuron death") + a(MESH:Macrophages) increases path(MESH:Inflammation) - pmid:17009926 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation bp(GO:"neuron death") + a(MESH:Macrophages) increases bp(GO:"establishment of blood-brain barrier") - pmid:17009926 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation bp(GO:"neuron death") + a(MESH:Macrophages) increases bp(MESH:Immunity) - pmid:24590577 + pubmed:30967783 - path(MESH:"Alzheimer Disease") increases bp(GO:"neuron death") + a(MESH:Macrophages) increases bp(MESH:Immunity) - pmid:25514383 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation bp(GO:"neuron death") + a(MESH:Macrophages) increases a(MESH:"Leukocytes, Mononuclear") - pmid:22040696 + pubmed:30967783 - path(MESH:"Alzheimer Disease") increases bp(GO:"neuron death") + a(MESH:Macrophages) decreases act(a(MESH:"Leukocytes, Mononuclear")) - pmid:28420982 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation bp(GO:"neuron death") + a(MESH:Macrophages) decreases a(MESH:"Leukocytes, Mononuclear", loc(MESH:"Central Nervous System")) - pmid:26631930 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation bp(GO:"neuron death") + a(MESH:Macrophages) isA a(MESH:"Antigen-Presenting Cells") - pmid:22122372 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:HBP00064) + a(MESH:Macrophages) isA a(MESH:"Antigen-Presenting Cells") - pmid:22122372 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:HBP00065) + a(MESH:Macrophages) isA a(MESH:"Antigen-Presenting Cells") - pmid:30061532 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + a(MESH:Macrophages) decreases a(NCIT:C120869) - pmid:30145931 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + a(MESH:Macrophages) increases bp(GO:"cerebrospinal fluid secretion") - pmid:17403556 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + a(MESH:Macrophages) increases bp(GO:"cerebrospinal fluid circulation") - pmid:25374103 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + a(MESH:Macrophages) increases p(HGNC:TRPM2) - pmid:26631930 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + a(MESH:Macrophages) increases tloc(p(HGNC:IL6), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:24401760 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + a(MESH:Macrophages) increases tloc(p(HGNC:IL12B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:19126755 + pubmed:30967783 - path(MESH:"Alzheimer Disease") negativeCorrelation p(HBP:"alpha-4 beta-2 nAChR") + a(MESH:Macrophages) increases tloc(p(HGNC:TNF), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:19126755 + pubmed:30967783 - path(MESH:"Alzheimer Disease") negativeCorrelation p(HBP:"alpha-4 beta-2 nAChR") + a(MESH:Macrophages) increases tloc(p(HGNC:IL1A), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:19721446 + pubmed:30967783 - path(MESH:"Alzheimer Disease") decreases p(HBP:"alpha-4 beta-2 nAChR") + a(MESH:Macrophages) increases tloc(p(MESH:Interleukin-23), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:19126755 + pubmed:30967783 - path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + a(MESH:Macrophages) increases p(HGNC:CCR4) - pmid:19126755 + pubmed:30967783 - path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + a(MESH:Macrophages) increases path(HP:"CNS demyelination") - pmid:19126755 + pubmed:30967783 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + a(MESH:Macrophages) increases p(HGNC:TREM1) - pmid:19293145 + pubmed:30967783 - path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + a(MESH:Macrophages) increases p(MESH:"Histocompatibility Antigens Class II") - pmid:19293145 + pubmed:30967783 - path(MESH:"Alzheimer Disease") decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + a(MESH:Macrophages) increases path(EFO:"experimental autoimmune encephalomyelitis") - pmid:19293145 + pubmed:30967783 - path(MESH:"Alzheimer Disease") association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + a(MESH:Macrophages) decreases path(EFO:"experimental autoimmune encephalomyelitis") - pmid:19293145 + pubmed:30967783 - path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + a(MESH:Macrophages) increases p(HGNC:VCAM1) - pmid:19293145 + pubmed:30967783 - path(MESH:"Alzheimer Disease") increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + a(MESH:Macrophages) increases p(HGNC:ICAM1) - pmid:24590577 + pubmed:30967783 - path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + a(MESH:Macrophages) increases p(HGNC:CCL2) - pmid:19721446 + pubmed:30967783 - path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + a(MESH:Macrophages) increases p(HGNC:CCL3) - pmid:19126755 + pubmed:30967783 - path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:CHRNA7) + a(MESH:Macrophages) increases bp(GO:"T cell activation") - pmid:19293145 + pubmed:30967783 - path(MESH:"Alzheimer Disease") association p(HGNC:CHRNA7) + a(MESH:Macrophages) increases p(MESH:"Nerve Growth Factors") - pmid:19293145 + pubmed:30967783 - path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA7) + a(MESH:Macrophages) increases p(MESH:"Anti-Inflammatory Agents") - pmid:19293145 + pubmed:30967783 - path(MESH:"Alzheimer Disease") increases p(HGNC:CHRNA7) + a(MESH:Macrophages) decreases p(HGNC:IFNG) - pmid:19293145 + pubmed:30967783 - path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA7) + a(MESH:Macrophages, loc(MESH:Brain)) regulates a(MESH:Microglia) - pmid:19293145 + pubmed:30046111 - path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA7) + a(CONSO:CONSO00018) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:11230871 + pubmed:21718217 - path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:CHRNA7) + a(CONSO:CONSO00018) association path(MESH:"Alzheimer Disease") - pmid:22040696 + pubmed:30046111 - path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:CHRNA7) + a(CONSO:CONSO00018) decreases bp(GO:"neuron cellular homeostasis") - pmid:29191965 + pubmed:30046111 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:CHRNA7) + a(CONSO:CONSO00018) increases path(MESH:"Problem Behavior") - pmid:19126755 + pubmed:29196815 - path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:Dementia) + a(CONSO:CONSO00018) causesNoChange bp(GO:"neuron death") - pmid:19293145 + pubmed:29196815 - path(MESH:"Alzheimer Disease") association path(MESH:Dementia) + a(CONSO:CONSO00018) causesNoChange bp(GO:"astrocyte activation") - pmid:24511233 + pubmed:22122372 - path(MESH:"Alzheimer Disease") association path(MESH:Dementia) + a(CONSO:CONSO00018) association a(MESH:"Amyloid beta-Peptides") - pmid:25514383 + pubmed:22122372 - path(MESH:"Alzheimer Disease") association path(MESH:Dementia) + a(CONSO:CONSO00018) increases path(MESH:"Plaque, Amyloid") - pmid:21718217 + pubmed:30046111 - path(MESH:"Alzheimer Disease") increases path(MESH:Dementia) + path(MESH:"Alzheimer Disease") positiveCorrelation a(CONSO:CONSO00018) - pmid:14556719 + pubmed:21718217 - path(MESH:"Alzheimer Disease") increases path(MESH:Dementia) + path(MESH:"Alzheimer Disease") association a(CONSO:CONSO00018) - pmid:19126755 + pubmed:22040696 - path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"synaptic transmission, cholinergic") + path(MESH:"Alzheimer Disease") increases a(CONSO:CONSO00018) - pmid:24511233 + pubmed:30046111 - path(MESH:"Alzheimer Disease") decreases bp(GO:"synaptic transmission, cholinergic") + path(MESH:"Alzheimer Disease") association act(a(MESH:"Lymphatic Vessels")) - pmid:24511233 + pubmed:30046111 - path(MESH:"Alzheimer Disease") decreases bp(GO:"synaptic transmission, cholinergic") + path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:amyloid-beta) - pmid:26813123 + pubmed:30046111 - path(MESH:"Alzheimer Disease") association bp(GO:"synaptic transmission, cholinergic") + path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:amyloid-beta) - pmid:24590577 + pubmed:30046111 - path(MESH:"Alzheimer Disease") decreases bp(GO:"synaptic transmission, cholinergic") + path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:amyloid-beta) - pmid:19126755 + pubmed:29196815 - path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Neurofibrillary Tangles") + path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:amyloid-beta) - pmid:24590577 + pubmed:29196815 - path(MESH:"Alzheimer Disease") association path(MESH:"Neurofibrillary Tangles") + path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:amyloid-beta) - pmid:24027553 + pubmed:19293145 - path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Neurofibrillary Tangles") + path(MESH:"Alzheimer Disease") association tloc(a(CHEBI:amyloid-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:19126755 + pubmed:19293145 - path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Neurogenic Inflammation") + path(MESH:"Alzheimer Disease") association a(CHEBI:amyloid-beta) - pmid:19126755 + pubmed:25514383 - path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:CHRNA4) + path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:amyloid-beta) - pmid:19293145 + pubmed:14556719 - path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA4) + path(MESH:"Alzheimer Disease") association a(CHEBI:amyloid-beta) - pmid:19293145 + pubmed:26195256 - path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA4) + path(MESH:"Alzheimer Disease") decreases deg(a(CHEBI:amyloid-beta)) - pmid:19293145 + pubmed:29626319 - path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA4) + path(MESH:"Alzheimer Disease") decreases deg(a(CHEBI:amyloid-beta)) - pmid:11230871 + pubmed:29626319 - path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:CHRNA4) + path(MESH:"Alzheimer Disease") increases a(CHEBI:amyloid-beta) - pmid:19293145 + pubmed:29980653 - path(MESH:"Alzheimer Disease") decreases bp(GO:memory) + path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:amyloid-beta) - pmid:24511233 + pubmed:30663117 - path(MESH:"Alzheimer Disease") decreases bp(GO:memory) + path(MESH:"Alzheimer Disease") positiveCorrelation r(HGNC:BACE1, loc(GO:cytoplasm)) - pmid:24511233 + pubmed:21329555 - path(MESH:"Alzheimer Disease") decreases bp(GO:memory) + path(MESH:"Alzheimer Disease") positiveCorrelation r(HGNC:BACE1) - pmid:22040696 + pubmed:30663117 - path(MESH:"Alzheimer Disease") decreases bp(GO:memory) + path(MESH:"Alzheimer Disease") positiveCorrelation r(HGNC:BACE1-AS) - pmid:19293145 + pubmed:30663117 - path(MESH:"Alzheimer Disease") decreases path(MESH:"Psychomotor Performance") + path(MESH:"Alzheimer Disease") association g(HGNC:MIR384) - pmid:19293145 + pubmed:30663117 - path(MESH:"Alzheimer Disease") association path(MESH:Death) + path(MESH:"Alzheimer Disease") association g(HGNC:MIR153-1) - pmid:19293145 + pubmed:30663117 - path(MESH:"Alzheimer Disease") positiveCorrelation a(MESH:"Neurofibrillary Tangles") + path(MESH:"Alzheimer Disease") association g(HGNC:MIR101-1) - pmid:14556719 + pubmed:30663117 - path(MESH:"Alzheimer Disease") increases a(MESH:"Neurofibrillary Tangles") + path(MESH:"Alzheimer Disease") association g(HGNC:MIR9-1) - pmid:19293145 + pubmed:30663117 - path(MESH:"Alzheimer Disease") association a(HBP:"amyloid-beta aggregates") + path(MESH:"Alzheimer Disease") decreases g(HGNC:MIR9-1) - pmid:25514383 + pubmed:16273023 - path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"amyloid-beta aggregates") + path(MESH:"Alzheimer Disease") decreases a(CHEBI:acetylcholine) - pmid:26195256 + pubmed:16273023 - path(MESH:"Alzheimer Disease") increases a(HBP:"amyloid-beta aggregates") + path(MESH:"Alzheimer Disease") decreases act(a(CHEBI:acetylcholine)) - pmid:22817713 + pubmed:26218288 - path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"amyloid-beta aggregates") + path(MESH:"Alzheimer Disease") negativeCorrelation a(CHEBI:acetylcholine) - pmid:19293145 + pubmed:19293145 - path(MESH:"Alzheimer Disease") increases p(HGNC:BCHE) + path(MESH:"Alzheimer Disease") decreases a(CHEBI:acetylcholine) - pmid:22020111 + pubmed:25514383 - path(MESH:"Alzheimer Disease") increases p(HGNC:BCHE) + path(MESH:"Alzheimer Disease") decreases a(CHEBI:acetylcholine) - pmid:19293145 + pubmed:16273023 - path(MESH:"Alzheimer Disease") decreases a(CHEBI:acetylcholine) + path(MESH:"Alzheimer Disease") negativeCorrelation a(CL:"cholinergic neuron") - pmid:25514383 + pubmed:16273023 - path(MESH:"Alzheimer Disease") decreases a(CHEBI:acetylcholine) + path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:ACHE)) - pmid:19293145 + pubmed:26813123 - path(MESH:"Alzheimer Disease") decreases act(p(HGNC:CHAT)) + path(MESH:"Alzheimer Disease") association p(HGNC:ACHE) - pmid:19293145 + pubmed:18986241 - path(MESH:"Alzheimer Disease") decreases act(p(HGNC:CHAT)) + path(MESH:"Alzheimer Disease") decreases p(HGNC:ACHE) - pmid:26813123 + pubmed:18986241 - path(MESH:"Alzheimer Disease") decreases act(p(HGNC:CHAT)) + path(MESH:"Alzheimer Disease") causesNoChange act(p(HGNC:ACHE)) - pmid:24590577 + pubmed:18986241 - path(MESH:"Alzheimer Disease") decreases p(HGNC:CHAT) + path(MESH:"Alzheimer Disease") decreases act(p(HGNC:ACHE)) - pmid:25514383 + pubmed:18986241 - path(MESH:"Alzheimer Disease") decreases act(p(HGNC:CHAT)) + path(MESH:"Alzheimer Disease") decreases act(p(HGNC:ACHE)) - pmid:19293145 + pubmed:11230871 - path(MESH:"Alzheimer Disease") decreases act(a(MESH:"Cholinesterase Inhibitors")) + path(MESH:"Alzheimer Disease") decreases act(p(HGNC:ACHE)) - pmid:19293145 + pubmed:11230871 - path(MESH:"Alzheimer Disease") association g(HGNC:CHAT) + path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:ACHE)) - pmid:19293145 + pubmed:11230871 - path(MESH:"Alzheimer Disease") association g(HGNC:ACHE) + path(MESH:"Alzheimer Disease") decreases act(p(HGNC:ACHE)) - pmid:19293145 + pubmed:16273023 - path(MESH:"Alzheimer Disease") association a(HBP:"alpha-4 beta-2 nAChR") + path(MESH:"Alzheimer Disease") association p(HGNC:REST) - pmid:11230871 + pubmed:16273023 - path(MESH:"Alzheimer Disease") decreases a(HBP:"alpha-4 beta-2 nAChR") + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SEPT2) - pmid:19293145 + pubmed:16273023 - path(MESH:"Alzheimer Disease") increases p(HGNC:FYN) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SEPT3) - pmid:19293145 + pubmed:16273023 - path(MESH:"Alzheimer Disease") increases p(HGNC:FYN) + path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:SEPT5) - pmid:19293145 + pubmed:" 23273601" - path(MESH:"Alzheimer Disease") increases complex(p(HGNC:FYN), p(HGNC:MAPT)) + path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:VAMP2) - pmid:24653673 + pubmed:" 23273601" - path(MESH:"Alzheimer Disease") positiveCorrelation complex(p(HGNC:FYN), p(HGNC:MAPT)) + path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:SNAP25) - pmid:19293145 + pubmed:" 23273601" - path(MESH:"Alzheimer Disease") association act(p(HGNC:INS)) + path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:SYN1) - pmid:19293145 + pubmed:" 23273601" - path(MESH:"Alzheimer Disease") association bp(GO:"regulation of cytosolic calcium ion concentration") + path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:SYN2) - pmid:19293145 + pubmed:" 23273601" - path(MESH:"Alzheimer Disease") association p(HGNC:PSEN1) + path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:SYT1) - pmid:19293145 + pubmed:" 23273601" - path(MESH:"Alzheimer Disease") association bp(GO:learning) + path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:SYT5) - pmid:24511233 + pubmed:" 23273601" - path(MESH:"Alzheimer Disease") decreases bp(GO:learning) + path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:DNM1) - pmid:24511233 + pubmed:" 23273601" - path(MESH:"Alzheimer Disease") decreases bp(GO:learning) + path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:DNM1L) - pmid:19293145 + pubmed:" 23273601" - path(MESH:"Alzheimer Disease") association path(MESH:"Cognitive Dysfunction") + path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:SYNPO) - pmid:24511233 + pubmed:" 23273601" - path(MESH:"Alzheimer Disease") association path(MESH:"Cognitive Dysfunction") + path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:RAB3A) - pmid:24511233 + pubmed:" 23273601" - path(MESH:"Alzheimer Disease") association path(MESH:"Cognitive Dysfunction") + path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:SEC22B) - pmid:26813123 + pubmed:" 23273601" - path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Cognitive Dysfunction") + path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:SNCA) - pmid:27522251 + pubmed:" 23273601" - path(MESH:"Alzheimer Disease") increases path(MESH:"Cognitive Dysfunction") + path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:SNCB) - pmid:19293145 + pubmed:" 23273601" - path(MESH:"Alzheimer Disease") positiveCorrelation g(HGNC:APOE) + path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:STXBP5L) - pmid:19293145 + pubmed:" 23273601" - path(MESH:"Alzheimer Disease") decreases a(MESH:"Cholinergic Neurons") + path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:STXBP6) - pmid:19293145 + pubmed:" 23273601" - path(MESH:"Alzheimer Disease") decreases a(MESH:"Cholinergic Neurons") + path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:BSN) - pmid:19293145 + pubmed:" 23273601" - path(MESH:"Alzheimer Disease") decreases a(MESH:"Cholinergic Neurons") + path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:PCLO) - pmid:24511233 + pubmed:" 23273601" - path(MESH:"Alzheimer Disease") decreases a(MESH:"Cholinergic Neurons") + path(MESH:"Alzheimer Disease") positiveCorrelation r(HGNC:SNAP23) - pmid:26813123 + pubmed:" 23273601" - path(MESH:"Alzheimer Disease") negativeCorrelation a(MESH:"Cholinergic Neurons") + path(MESH:"Alzheimer Disease") positiveCorrelation r(HGNC:SYNPO2) - pmid:24590577 + pubmed:" 23273601" - path(MESH:"Alzheimer Disease") decreases a(MESH:"Cholinergic Neurons") + path(MESH:"Alzheimer Disease") positiveCorrelation r(HGNC:VAMP1) - pmid:24590577 + pubmed:18986241 - path(MESH:"Alzheimer Disease") decreases a(MESH:"Cholinergic Neurons") + path(MESH:"Alzheimer Disease") causesNoChange r(HGNC:VAMP1) - pmid:19293145 + pubmed:26218288 - path(MESH:"Alzheimer Disease") decreases complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) + path(MESH:"Alzheimer Disease") positiveCorrelation path(HP:"Neuronal loss in central nervous system") - pmid:19293145 + pubmed:24107444 - path(MESH:"Alzheimer Disease") decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) + path(MESH:"Alzheimer Disease") negativeCorrelation g(HGNC:PSEN1) - pmid:19293145 + pubmed:17361039 - path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA3) + path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:SLC1A3) - pmid:19293145 + pubmed:17361039 - path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA3) + path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:SLC1A3) - pmid:19293145 + pubmed:17361039 - path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA3) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SLC1A3) - pmid:11230871 + pubmed:17361039 - path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:CHRNA3) + path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:SLC1A2) - pmid:11230871 + pubmed:17361039 - path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:CHRNA3) + path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:SLC1A2) - pmid:11230871 + pubmed:17361039 - path(MESH:"Alzheimer Disease") causesNoChange p(HGNC:CHRNA3) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SLC1A2) - pmid:19293145 + pubmed:17361039 - path(MESH:"Alzheimer Disease") causesNoChange r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + path(MESH:"Alzheimer Disease") positiveCorrelation r(HGNC:GRIK4) - pmid:19293145 + pubmed:17361039 - path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNB4) + path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:POLR2M) - pmid:19293145 + pubmed:17361039 - path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits") + path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:GRIA4) - pmid:19293145 + pubmed:25932647 - path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Glutamate ionotropic receptor AMPA type subunits") + path(MESH:"Alzheimer Disease") negativeCorrelation p(INTERPRO:"Serine/threonine-protein kinase MARK/par1") - pmid:19293145 + pubmed:21329555 - path(MESH:"Alzheimer Disease") decreases p(HGNC:GABRB3) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:RELA) - pmid:19293145 + pubmed:25652642 - path(MESH:"Alzheimer Disease") causesNoChange p(MGI:Chrna7) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:RELA, loc(GO:nucleus)) - pmid:25881725 + pubmed:21329555 - path(MESH:"Alzheimer Disease") negativeCorrelation p(MGI:Chrna7) + path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:Inflammation) - pmid:19293145 + pubmed:27288790 - path(MESH:"Alzheimer Disease") causesNoChange p(MGI:Chrna4) + path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:Inflammation) - pmid:24511233 + pubmed:24027553 - path(MESH:"Alzheimer Disease") association path(MESH:"Psychotic Disorders") + path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:Inflammation) - pmid:24511233 + pubmed:28745240 - path(MESH:"Alzheimer Disease") association path(MESH:"Psychotic Disorders") + path(MESH:"Alzheimer Disease") association p(HGNC:IL6) - pmid:24511233 + pubmed:25652642 - path(MESH:"Alzheimer Disease") association path(MESH:"Psychotic Disorders") + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL6) - pmid:24511233 + pubmed:28745240 - path(MESH:"Alzheimer Disease") increases path(MESH:Depression) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:TNF) - pmid:26813123 + pubmed:27288790 - path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:Depression) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:TNF) - pmid:24511233 + pubmed:25652642 - path(MESH:"Alzheimer Disease") increases path(MESH:Anxiety) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:TNF) - pmid:24511233 + pubmed:29179999 - path(MESH:"Alzheimer Disease") association bp(MESH:Aging) + path(MESH:"Alzheimer Disease") positiveCorrelation p(FPLX:NFkappaB) - pmid:17009926 + pubmed:27288790 - path(MESH:"Alzheimer Disease") association p(FPLX:CHRN) + path(MESH:"Alzheimer Disease") positiveCorrelation act(p(FPLX:NFkappaB)) - pmid:17009926 + pubmed:27288790 - path(MESH:"Alzheimer Disease") negativeCorrelation act(p(FPLX:CHRN)) + path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"regulation of synaptic plasticity") - pmid:17009926 + pubmed:27288790 - path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:CHRN) + path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:"reactive oxygen species") - pmid:17009926 + pubmed:27288790 - path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:CHRN) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL1B) - pmid:25514383 + pubmed:25652642 - path(MESH:"Alzheimer Disease") decreases p(FPLX:CHRN) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL1B) - pmid:11230871 + pubmed:24561250 - path(MESH:"Alzheimer Disease") association p(FPLX:CHRN) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL1B) - pmid:11230871 + pubmed:27314526 - path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:CHRN) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL1B) - pmid:17009926 + pubmed:27288790 - path(MESH:"Alzheimer Disease") association complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7)) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL18) - pmid:26813123 + pubmed:24561250 - path(MESH:"Alzheimer Disease") increases deg(a(MESH:"Basal Nucleus of Meynert")) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL18) - pmid:26813123 + pubmed:27314526 - path(MESH:"Alzheimer Disease") negativeCorrelation a(MESH:"Basal Nucleus of Meynert") + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:IL18) - pmid:26813123 + pubmed:27314526 - path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:Apathy) + path(MESH:"Alzheimer Disease") association p(HGNC:IL18) - pmid:26813123 + pubmed:27288790 - path(MESH:"Alzheimer Disease") association p(HGNC:ACHE) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:CXCL10) - pmid:11230871 + pubmed:27288790 - path(MESH:"Alzheimer Disease") decreases act(p(HGNC:ACHE)) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:TGFB1) - pmid:11230871 + pubmed:27288790 - path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:ACHE)) + path(MESH:"Alzheimer Disease") positiveCorrelation bp(GO:"MAPK cascade") - pmid:11230871 + pubmed:27288790 - path(MESH:"Alzheimer Disease") decreases act(p(HGNC:ACHE)) + path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:pentosidine) - pmid:26813123 + pubmed:27288790 - path(MESH:"Alzheimer Disease") negativeCorrelation a(CHEBI:rivastigmine) + path(MESH:"Alzheimer Disease") positiveCorrelation a(CONSO:GLAP) - pmid:26813123 + pubmed:27288790 - path(MESH:"Alzheimer Disease") negativeCorrelation complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:PTGS2) - pmid:24590577 + pubmed:27288790 - path(MESH:"Alzheimer Disease") association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") + path(MESH:"Alzheimer Disease") positiveCorrelation m(MIRBASE:hsa-mir-146a) - pmid:19721446 + pubmed:27288790 - path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") + path(MESH:"Alzheimer Disease") positiveCorrelation m(MIRBASE:hsa-mir-155) - pmid:25514383 + pubmed:25652642 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT) + path(MESH:"Alzheimer Disease") positiveCorrelation complex(a(GO:"NF-kappaB complex"), p(HGNC:RELA)) - pmid:29758300 + pubmed:25652642 - path(MESH:"Alzheimer Disease") association p(HGNC:MAPT) + path(MESH:"Alzheimer Disease") positiveCorrelation act(complex(GO:"NF-kappaB complex")) - pmid:14556719 + pubmed:25652642 - path(MESH:"Alzheimer Disease") association p(HGNC:MAPT) + path(MESH:"Alzheimer Disease") positiveCorrelation complex(GO:"NF-kappaB complex") - pmid:24027553 + pubmed:25652642 - path(MESH:"Alzheimer Disease") association p(HGNC:MAPT) + path(MESH:"Alzheimer Disease") positiveCorrelation complex(GO:"NF-kappaB complex") - pmid:24027553 + pubmed:25652642 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT) + path(MESH:"Alzheimer Disease") positiveCorrelation a(MESH:"HLA-DR Antigens") - pmid:27574109 + pubmed:25652642 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT) + path(MESH:"Alzheimer Disease") positiveCorrelation m(HGNC:MIR9-1) - pmid:27574109 + pubmed:25652642 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT) + path(MESH:"Alzheimer Disease") positiveCorrelation m(HGNC:MIR34A) - pmid:30126037 + pubmed:25652642 - path(MESH:"Alzheimer Disease") association p(HGNC:MAPT) + path(MESH:"Alzheimer Disease") positiveCorrelation m(HGNC:MIR125B1) - pmid:22419736 + pubmed:25652642 - path(MESH:"Alzheimer Disease") causesNoChange p(HGNC:MAPT) + path(MESH:"Alzheimer Disease") positiveCorrelation m(HGNC:MIR146A) - pmid:25374103 + pubmed:24586483 - path(MESH:"Alzheimer Disease") increases tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) + path(MESH:"Alzheimer Disease") association m(HGNC:MIR146A) - pmid:28420982 + pubmed:24586483 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT) + path(MESH:"Alzheimer Disease") association m(HGNC:MIR146A) - pmid:28420982 + pubmed:25652642 - path(MESH:"Alzheimer Disease") increases p(HGNC:MAPT) + path(MESH:"Alzheimer Disease") positiveCorrelation m(HGNC:MIR155) - pmid:28420982 + pubmed:25652642 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT) + path(MESH:"Alzheimer Disease") positiveCorrelation m(HGNC:MIR339) - pmid:26631930 + pubmed:10656250 - path(MESH:"Alzheimer Disease") increases tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) + path(MESH:"Alzheimer Disease") increases p(HGNC:BACE1) - pmid:26631930 + pubmed:30444369 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:HSD17B10) - pmid:29980653 + pubmed:30444369 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT) + path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:PRDX2)) - pmid:25514383 + pubmed:30444369 - path(MESH:"Alzheimer Disease") negativeCorrelation a(GO:synapse) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:PRDX2) - pmid:22908190 + pubmed:30444369 - path(MESH:"Alzheimer Disease") negativeCorrelation act(a(GO:synapse)) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:CDK5) - pmid:22908190 + pubmed:24653673 - path(MESH:"Alzheimer Disease") negativeCorrelation act(a(GO:synapse)) + path(MESH:"Alzheimer Disease") association p(HGNC:CDK5) - pmid:25514383 + pubmed:8282104 - path(MESH:"Alzheimer Disease") negativeCorrelation a(MESH:"White Matter") + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:CDK5) - pmid:26195256 + pubmed:30444369 - path(MESH:"Alzheimer Disease") association a(MESH:"White Matter") + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SH3GL2) - pmid:25514383 + pubmed:29196815 - path(MESH:"Alzheimer Disease") negativeCorrelation a(HP:"cholinergic neuron") + path(MESH:"Alzheimer Disease") isA path(MESH:"Neurodegenerative Diseases") - pmid:25514383 + pubmed:24511233 - path(MESH:"Alzheimer Disease") decreases complex(a(CHEBI:acetylcholine), p(FPLX:CHRN)) + path(MESH:"Alzheimer Disease") isA path(MESH:"Neurodegenerative Diseases") - pmid:25514383 + pubmed:24590577 - path(MESH:"Alzheimer Disease") decreases complex(a(CHEBI:acetylcholine), p(FPLX:CHRM)) + path(MESH:"Alzheimer Disease") isA path(MESH:"Neurodegenerative Diseases") - pmid:25514383 + pubmed:18986241 - path(MESH:"Alzheimer Disease") decreases complex(a(CHEBI:nicotine), p(FPLX:CHRN)) + path(MESH:"Alzheimer Disease") association path(MESH:"Neurodegenerative Diseases") - pmid:11230871 + pubmed:29980653 - path(MESH:"Alzheimer Disease") decreases complex(a(CHEBI:nicotine), p(FPLX:CHRN)) + path(MESH:"Alzheimer Disease") isA path(MESH:"Neurodegenerative Diseases") - pmid:25514383 + pubmed:29196815 - path(MESH:"Alzheimer Disease") decreases complex(a(CHEBI:nicotine), p(FPLX:CHRM)) + path(MESH:"Alzheimer Disease") decreases bp(GO:cognition) - pmid:25514383 + pubmed:19126755 - path(MESH:"Alzheimer Disease") decreases p(FPLX:CHRM) + path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:cognition) - pmid:25514383 + pubmed:19293145 - path(MESH:"Alzheimer Disease") positiveCorrelation complex(p(HGNC:CHRNA7), p(HGNC:FLNA)) + path(MESH:"Alzheimer Disease") decreases bp(GO:cognition) - pmid:21718217 + pubmed:24511233 - path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:HBP00030) + path(MESH:"Alzheimer Disease") association bp(GO:cognition) - pmid:21718217 + pubmed:24511233 - path(MESH:"Alzheimer Disease") positiveCorrelation r(HGNC:ARG1) + path(MESH:"Alzheimer Disease") decreases bp(GO:cognition) - pmid:21718217 + pubmed:24590577 - path(MESH:"Alzheimer Disease") positiveCorrelation r(HGNC:CHI3L1) + path(MESH:"Alzheimer Disease") decreases bp(GO:cognition) - pmid:21718217 + pubmed:11230871 - path(MESH:"Alzheimer Disease") association p(HBP:HBP00030) + path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:cognition) - pmid:11230871 + pubmed:19721446 - path(MESH:"Alzheimer Disease") negativeCorrelation p(HBP:"alpha-4-containing nAChR") + path(MESH:"Alzheimer Disease") decreases bp(GO:cognition) - pmid:11230871 + pubmed:29196815 - path(MESH:"Alzheimer Disease") causesNoChange p(HBP:"alpha-7-containing nAChR") + path(MESH:"Alzheimer Disease") increases bp(GO:"neuron apoptotic process") - pmid:11230871 + pubmed:29196815 - path(MESH:"Alzheimer Disease") negativeCorrelation p(HBP:"alpha-7-containing nAChR") + path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Plaque, Amyloid") - pmid:11230871 + pubmed:19126755 - path(MESH:"Alzheimer Disease") positiveCorrelation r(HGNC:CHRNA7) + path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Plaque, Amyloid") - pmid:11230871 + pubmed:19293145 - path(MESH:"Alzheimer Disease") causesNoChange r(HGNC:CHRNA3) + path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Plaque, Amyloid") - pmid:11230871 + pubmed:19293145 - path(MESH:"Alzheimer Disease") causesNoChange r(HGNC:CHRNA4) + path(MESH:"Alzheimer Disease") association path(MESH:"Plaque, Amyloid") - pmid:19721446 + pubmed:24590577 - path(MESH:"Alzheimer Disease") decreases a(MESH:Neurons) + path(MESH:"Alzheimer Disease") association path(MESH:"Plaque, Amyloid") - pmid:19721446 + pubmed:25514383 - path(MESH:"Alzheimer Disease") decreases path(MESH:"Memory, Episodic") + path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Plaque, Amyloid") - pmid:26837465 + pubmed:19721446 - path(MESH:"Alzheimer Disease") increases complex(p(HGNC:ESR1), p(HGNC:MAPT)) + path(MESH:"Alzheimer Disease") increases path(MESH:"Plaque, Amyloid") - pmid:21787755 + pubmed:29758300 - path(MESH:"Alzheimer Disease") association a(HBP:AβOs) + path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Plaque, Amyloid") - pmid:28901280 + pubmed:14556719 - path(MESH:"Alzheimer Disease") association p(MESH:"Receptors, Nicotinic") + path(MESH:"Alzheimer Disease") increases path(MESH:"Plaque, Amyloid") - pmid:23178521 + pubmed:22817713 - path(MESH:"Alzheimer Disease") increases p(MGI:Il6) + path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Plaque, Amyloid") - pmid:23178521 + pubmed:29196815 - path(MESH:"Alzheimer Disease") increases p(MGI:Tnf) + path(MESH:"Alzheimer Disease") positiveCorrelation a(MESH:"Amyloid beta-Peptides") - pmid:23178521 + pubmed:22122372 - path(MESH:"Alzheimer Disease") increases p(MGI:Stat3, pmod(Ph)) + path(MESH:"Alzheimer Disease") association a(MESH:"Amyloid beta-Peptides") - pmid:22020111 + pubmed:29196815 - path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"protein aggregates") + path(MESH:"Alzheimer Disease") positiveCorrelation a(GO:"neurofibrillary tangle") - pmid:22020111 + pubmed:28420982 - path(MESH:"Alzheimer Disease") increases p(HGNC:AGRN) + path(MESH:"Alzheimer Disease") positiveCorrelation a(GO:"neurofibrillary tangle") - pmid:22020111 + pubmed:22817713 - path(MESH:"Alzheimer Disease") increases p(HGNC:ANP32A) + path(MESH:"Alzheimer Disease") association a(GO:"neurofibrillary tangle") - pmid:24653673 + pubmed:11089576 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:ANP32A) + path(MESH:"Alzheimer Disease") positiveCorrelation a(GO:"neurofibrillary tangle") - pmid:22299660 + pubmed:29196815 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:ANP32A) + path(MESH:"Alzheimer Disease") positiveCorrelation a(CONSO:CONSO00074) - pmid:22020111 + pubmed:29196815 - path(MESH:"Alzheimer Disease") increases p(HGNC:BAX) + path(MESH:"Alzheimer Disease") positiveCorrelation a(CONSO:CONSO00074) - pmid:22020111 + pubmed:29196815 - path(MESH:"Alzheimer Disease") increases p(HGNC:BGN) + path(MESH:"Alzheimer Disease") negativeCorrelation a(CHEBI:"amyloid-beta polypeptide 42") - pmid:22020111 + pubmed:19293145 - path(MESH:"Alzheimer Disease") increases p(HGNC:BRCA1) + path(MESH:"Alzheimer Disease") association a(CHEBI:"amyloid-beta polypeptide 42") - pmid:22020111 + pubmed:29196815 - path(MESH:"Alzheimer Disease") increases p(HGNC:CADPS2) + path(MESH:"Alzheimer Disease") positiveCorrelation a(CONSO:CONSO00076) - pmid:22020111 + pubmed:29196815 - path(MESH:"Alzheimer Disease") increases p(HGNC:CAPN1) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:NGFR) - pmid:22020111 + pubmed:21214928 - path(MESH:"Alzheimer Disease") increases p(HGNC:CCNB1) + path(MESH:"Alzheimer Disease") positiveCorrelation r(CONSO:CONSO00064) - pmid:22020111 + pubmed:21214928 - path(MESH:"Alzheimer Disease") increases p(HGNC:CDK1) + path(MESH:"Alzheimer Disease") positiveCorrelation p(CONSO:CONSO00065) - pmid:22020111 + pubmed:22122372 - path(MESH:"Alzheimer Disease") increases p(HGNC:CDK2) + path(MESH:"Alzheimer Disease") positiveCorrelation p(CONSO:CONSO00065) - pmid:22020111 + pubmed:21214928 - path(MESH:"Alzheimer Disease") increases p(HGNC:CDKN2A) + path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:ADAM10) - pmid:22020111 + pubmed:21214928 - path(MESH:"Alzheimer Disease") increases p(HGNC:CXCR4) + path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:ADAM10)) - pmid:22020111 + pubmed:21214928 - path(MESH:"Alzheimer Disease") increases p(HGNC:EIF4EBP1) + path(MESH:"Alzheimer Disease") negativeCorrelation p(CONSO:CONSO00067) - pmid:22020111 + pubmed:22122372 - path(MESH:"Alzheimer Disease") increases p(HGNC:FOLH1) + path(MESH:"Alzheimer Disease") association bp(GO:"neurofibrillary tangle assembly") - pmid:22020111 + pubmed:22122372 - path(MESH:"Alzheimer Disease") increases p(HGNC:HOMER1) + path(MESH:"Alzheimer Disease") association bp(GO:"neuron death") - pmid:22020111 + pubmed:14970312 - path(MESH:"Alzheimer Disease") increases p(HGNC:HRH1) + path(MESH:"Alzheimer Disease") increases bp(GO:"neuron death") - pmid:22020111 + pubmed:19293145 - path(MESH:"Alzheimer Disease") increases p(HGNC:IGF2) + path(MESH:"Alzheimer Disease") increases bp(GO:"neuron death") - pmid:22020111 + pubmed:17009926 - path(MESH:"Alzheimer Disease") increases p(HGNC:IGFBP2) + path(MESH:"Alzheimer Disease") positiveCorrelation bp(GO:"neuron death") - pmid:22020111 + pubmed:17009926 - path(MESH:"Alzheimer Disease") increases p(HGNC:LDLR) + path(MESH:"Alzheimer Disease") positiveCorrelation bp(GO:"neuron death") - pmid:22020111 + pubmed:24590577 - path(MESH:"Alzheimer Disease") increases p(HGNC:MAOA) + path(MESH:"Alzheimer Disease") increases bp(GO:"neuron death") - pmid:22020111 + pubmed:25514383 - path(MESH:"Alzheimer Disease") increases p(HGNC:NEFH) + path(MESH:"Alzheimer Disease") positiveCorrelation bp(GO:"neuron death") - pmid:22020111 + pubmed:22040696 - path(MESH:"Alzheimer Disease") increases p(HGNC:NPDC1) + path(MESH:"Alzheimer Disease") increases bp(GO:"neuron death") - pmid:22020111 + pubmed:28420982 - path(MESH:"Alzheimer Disease") increases p(HGNC:NRGN) + path(MESH:"Alzheimer Disease") positiveCorrelation bp(GO:"neuron death") - pmid:22020111 + pubmed:26631930 - path(MESH:"Alzheimer Disease") increases p(HGNC:PREP) + path(MESH:"Alzheimer Disease") positiveCorrelation bp(GO:"neuron death") - pmid:22020111 + pubmed:22122372 - path(MESH:"Alzheimer Disease") increases p(HGNC:PROS1) + path(MESH:"Alzheimer Disease") positiveCorrelation p(CONSO:CONSO00064) - pmid:22020111 + pubmed:22110360 - path(MESH:"Alzheimer Disease") increases p(HGNC:PTGS1) + path(MESH:"Alzheimer Disease") association p(HGNC:DYRK1A) - pmid:22020111 + pubmed:26136662 - path(MESH:"Alzheimer Disease") increases p(HGNC:SELENBP1) + path(MESH:"Alzheimer Disease") association p(FPLX:Histone, pmod(go:0006473 ! "protein acetylation", Lys, 280)) - pmid:22020111 + pubmed:27041503 - path(MESH:"Alzheimer Disease") increases p(HGNC:TAGLN) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT) - pmid:22020111 + pubmed:3122646 - path(MESH:"Alzheimer Disease") increases p(HGNC:TUBB3) + path(MESH:"Alzheimer Disease") increases tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"cell body")) - pmid:22020111 + pubmed:25514383 - path(MESH:"Alzheimer Disease") increases p(HGNC:VKORC1) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT) - pmid:22020111 + pubmed:29758300 - path(MESH:"Alzheimer Disease") decreases p(HGNC:CANX) + path(MESH:"Alzheimer Disease") association p(HGNC:MAPT) - pmid:22020111 + pubmed:14556719 - path(MESH:"Alzheimer Disease") decreases p(HGNC:GCNT2) + path(MESH:"Alzheimer Disease") association p(HGNC:MAPT) - pmid:22020111 + pubmed:24027553 - path(MESH:"Alzheimer Disease") decreases p(HGNC:IDE) + path(MESH:"Alzheimer Disease") association p(HGNC:MAPT) - pmid:30116051 + pubmed:24027553 - path(MESH:"Alzheimer Disease") decreases p(HGNC:IDE) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT) - pmid:22020111 + pubmed:27574109 - path(MESH:"Alzheimer Disease") decreases p(HGNC:MMP1) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT) - pmid:22020111 + pubmed:27574109 - path(MESH:"Alzheimer Disease") decreases p(HGNC:NFE2L2) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT) - pmid:22020111 + pubmed:30126037 - path(MESH:"Alzheimer Disease") decreases p(HGNC:NR3C1) + path(MESH:"Alzheimer Disease") association p(HGNC:MAPT) - pmid:22020111 + pubmed:22419736 - path(MESH:"Alzheimer Disease") decreases p(HGNC:PPARA) + path(MESH:"Alzheimer Disease") causesNoChange p(HGNC:MAPT) - pmid:22020111 + pubmed:25374103 - path(MESH:"Alzheimer Disease") decreases p(HGNC:SLC6A6) + path(MESH:"Alzheimer Disease") increases tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) - pmid:22020111 + pubmed:28420982 - path(MESH:"Alzheimer Disease") decreases p(HGNC:SYVN1) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT) - pmid:22020111 + pubmed:28420982 - path(MESH:"Alzheimer Disease") decreases p(HGNC:TSHZ1) + path(MESH:"Alzheimer Disease") increases p(HGNC:MAPT) - pmid:22020111 + pubmed:28420982 - path(MESH:"Alzheimer Disease") decreases p(HGNC:TXN) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT) - pmid:22020111 + pubmed:26631930 - path(MESH:"Alzheimer Disease") decreases p(HGNC:ACLY) + path(MESH:"Alzheimer Disease") increases tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) - pmid:22020111 + pubmed:26631930 - path(MESH:"Alzheimer Disease") decreases p(HGNC:ATAD2) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT) - pmid:22020111 + pubmed:20869593 - path(MESH:"Alzheimer Disease") decreases p(HGNC:BECN1) + path(MESH:"Alzheimer Disease") association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:29758300 + pubmed:24653673 - path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:BECN1) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:29758300 + pubmed:8282104 - path(MESH:"Alzheimer Disease") decreases p(HGNC:BECN1) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:22020111 + pubmed:24027553 - path(MESH:"Alzheimer Disease") decreases p(HGNC:DHCR24) + path(MESH:"Alzheimer Disease") regulates p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:22020111 + pubmed:29191965 - path(MESH:"Alzheimer Disease") decreases p(HGNC:FGF2) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:22020111 + pubmed:29191965 - path(MESH:"Alzheimer Disease") decreases p(HGNC:HTRA1) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:24027553 + pubmed:29311797 - path(MESH:"Alzheimer Disease") association p(HGNC:HTRA1) + path(MESH:"Alzheimer Disease") association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:22020111 + pubmed:26458742 - path(MESH:"Alzheimer Disease") decreases p(HGNC:PRKCE) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:22020111 + pubmed:26631930 - path(MESH:"Alzheimer Disease") decreases p(HGNC:PRKDC) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:22020111 + pubmed:26631930 - path(MESH:"Alzheimer Disease") decreases p(HGNC:SCD) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:22020111 + pubmed:22817713 - path(MESH:"Alzheimer Disease") decreases p(HGNC:TUBB) + path(MESH:"Alzheimer Disease") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:22020111 + pubmed:22710270 - path(MESH:"Alzheimer Disease") decreases p(HGNC:UNG) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:PSEN1, var("p.Glu280Ala")) - pmid:22020111 + pubmed:22710270 - path(MESH:"Alzheimer Disease") increases p(HGNC:ATP1A1) + path(MESH:"Alzheimer Disease") association g(HGNC:CD44) - pmid:22020111 + pubmed:22710270 - path(MESH:"Alzheimer Disease") increases p(HGNC:CTSD) + path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs187116) - pmid:22020111 + pubmed:22710270 - path(MESH:"Alzheimer Disease") increases p(HGNC:GLRX) + path(MESH:"Alzheimer Disease") association g(HGNC:NPHP1) - pmid:22020111 + pubmed:22710270 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:GLRX) + path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs10173717) - pmid:22020111 + pubmed:22710270 - path(MESH:"Alzheimer Disease") increases p(HGNC:HMOX1) + path(MESH:"Alzheimer Disease") association g(HGNC:CADPS2) - pmid:22020111 + pubmed:22020111 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:HMOX1) + path(MESH:"Alzheimer Disease") increases g(HGNC:CADPS2) - pmid:22020111 + pubmed:22710270 - path(MESH:"Alzheimer Disease") increases p(HGNC:IL6R) + path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs3757536) - pmid:22020111 + pubmed:22710270 - path(MESH:"Alzheimer Disease") increases p(HGNC:NPTX1) + path(MESH:"Alzheimer Disease") association g(HGNC:GREM2) - pmid:22020111 + pubmed:22710270 - path(MESH:"Alzheimer Disease") increases p(HGNC:NQO1) + path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs12129547) - pmid:22020111 + pubmed:21769591 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:NQO1) + path(MESH:"Alzheimer Disease") association p(HGNC:APOE) - pmid:22020111 + pubmed:22159054 - path(MESH:"Alzheimer Disease") increases p(HGNC:PHF1) + path(MESH:"Alzheimer Disease") association p(HGNC:APOE) - pmid:22020111 + pubmed:18191876 - path(MESH:"Alzheimer Disease") increases p(HGNC:PRKCD) + path(MESH:"Alzheimer Disease") association p(HGNC:A2M, var("p.Val1000Ile")) - pmid:22020111 + pubmed:18191876 - path(MESH:"Alzheimer Disease") increases p(HGNC:RANBP9) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs669) - pmid:22020111 + pubmed:18191876 - path(MESH:"Alzheimer Disease") increases p(HGNC:SOD1) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs669) - pmid:22020111 + pubmed:18191876 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SOD1) + path(MESH:"Alzheimer Disease") association p(HGNC:OLR1) - pmid:22020111 + pubmed:18191876 - path(MESH:"Alzheimer Disease") positiveCorrelation bp(MESH:"Oxidative Stress") + path(MESH:"Alzheimer Disease") association p(HGNC:OLR1) - pmid:23454242 + pubmed:20693622 - path(MESH:"Alzheimer Disease") increases p(HGNC:SET) + path(MESH:"Alzheimer Disease") association p(HGNC:CYP46A1) - pmid:24653673 + pubmed:20693622 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SET) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs8003602) - pmid:22299660 + pubmed:20693622 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SET) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs3783320) - pmid:23454242 + pubmed:19926167 - path(MESH:"Alzheimer Disease") decreases act(p(FPLX:PPP2)) + path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs17571) - pmid:22299660 + pubmed:21892414 - path(MESH:"Alzheimer Disease") negativeCorrelation act(p(FPLX:PPP2)) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:CLU) - pmid:22299660 + pubmed:22159054 - path(MESH:"Alzheimer Disease") negativeCorrelation act(p(FPLX:PPP2)) + path(MESH:"Alzheimer Disease") association p(HGNC:CLU) - pmid:24653673 + pubmed:21892414 - path(MESH:"Alzheimer Disease") association p(HGNC:GSK3B) + path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs9331888) - pmid:24653673 + pubmed:22382309 - path(MESH:"Alzheimer Disease") association a(MESH:"Receptors, N-Methyl-D-Aspartate") + path(MESH:"Alzheimer Disease") positiveCorrelation g(HGNC:CD33) - pmid:24653673 + pubmed:22167654 - path(MESH:"Alzheimer Disease") association p(HGNC:GRM5) + path(MESH:"Alzheimer Disease") positiveCorrelation g(HGNC:CD33) - pmid:24653673 + pubmed:21460841 - path(MESH:"Alzheimer Disease") negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) + path(MESH:"Alzheimer Disease") association g(HGNC:CD33) - pmid:24653673 + pubmed:22382309 - path(MESH:"Alzheimer Disease") positiveCorrelation complex(GO:"protein phosphatase type 2A complex") + path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs3865444) - pmid:24653673 + pubmed:21460841 - path(MESH:"Alzheimer Disease") negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs3865444) - pmid:24653673 + pubmed:22382309 - path(MESH:"Alzheimer Disease") negativeCorrelation g(HGNC:PPP2CA) + path(MESH:"Alzheimer Disease") positiveCorrelation g(HGNC:MS4A6A) - pmid:24653673 + pubmed:22382309 - path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:PPP2CA) + path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs610932) - pmid:22299660 + pubmed:21460840 - path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:PPP2CA) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs610932) - pmid:22299660 + pubmed:22167654 - path(MESH:"Alzheimer Disease") causesNoChange r(HGNC:PPP2CA) + path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs3826656) - pmid:24653673 + pubmed:22167654 - path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PPP2CA) + path(MESH:"Alzheimer Disease") positiveCorrelation g(HGNC:GOLM1) - pmid:26631930 + pubmed:22167654 - path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:PPP2CA)) + path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs10868366) - pmid:24653673 + pubmed:22167654 - path(MESH:"Alzheimer Disease") negativeCorrelation g(HGNC:PPP2CB) + path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs7019241) - pmid:24653673 + pubmed:21285854 - path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:PPP2CB) + path(MESH:"Alzheimer Disease") association g(HGNC:GAB2) - pmid:22299660 + pubmed:17553421 - path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:PPP2CB) + path(MESH:"Alzheimer Disease") association g(HGNC:GAB2) - pmid:24653673 + pubmed:21285854 - path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PPP2CB) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs4945261) - pmid:24653673 + pubmed:21285854 - path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:PPP2R2C) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs7101429) - pmid:24653673 + pubmed:21285854 - path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:PPP2R5E) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs7115850) - pmid:24653673 + pubmed:22159054 - path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PPP2R2A) + path(MESH:"Alzheimer Disease") association p(HGNC:NECTIN2) - pmid:22299660 + pubmed:22159054 - path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PPP2R2A) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs6859) - pmid:24653673 + pubmed:22159054 - path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:PPP2, pmod(Me)) + path(MESH:"Alzheimer Disease") association p(HGNC:PICALM) - pmid:24653673 + pubmed:29626319 - path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:PPP2, pmod(Me)) + path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PICALM) - pmid:24653673 + pubmed:27260836 - path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:PPP2, pmod(Me)) + path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PICALM) - pmid:29281045 + pubmed:22159054 - path(MESH:"Alzheimer Disease") decreases p(FPLX:PPP2, pmod(Me)) + path(MESH:"Alzheimer Disease") association p(HGNC:BIN1) - pmid:24653673 + pubmed:29758300 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SET, frag("?")) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:BIN1) - pmid:24653673 + pubmed:22159054 - path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PTPA) + path(MESH:"Alzheimer Disease") association p(HGNC:EPHA1) - pmid:24653673 + pubmed:22159054 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 231)) + path(MESH:"Alzheimer Disease") association p(HGNC:MS4A7) - pmid:17403556 + pubmed:22159054 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 231)) + path(MESH:"Alzheimer Disease") association p(HGNC:ABCA7) - pmid:17403556 + pubmed:23556446 - path(MESH:"Alzheimer Disease") increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) + path(MESH:"Alzheimer Disease") association p(HGNC:ABCA7) - pmid:22253473 + pubmed:22159054 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 231)) + path(MESH:"Alzheimer Disease") association p(HGNC:CD33) - pmid:24653673 + pubmed:22005930 - path(MESH:"Alzheimer Disease") negativeCorrelation complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) + path(MESH:"Alzheimer Disease") association g(HGNC:SLC29A2) - pmid:24653673 + pubmed:22005930 - path(MESH:"Alzheimer Disease") negativeCorrelation complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs6834555) - pmid:24653673 + pubmed:22005930 - path(MESH:"Alzheimer Disease") negativeCorrelation complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) + path(MESH:"Alzheimer Disease") association g(HGNC:VSNL1) - pmid:24653673 + pubmed:22005930 - path(MESH:"Alzheimer Disease") negativeCorrelation complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs4038131) - pmid:24653673 + pubmed:21460840 - path(MESH:"Alzheimer Disease") negativeCorrelation complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) + path(MESH:"Alzheimer Disease") association g(HGNC:ABCA7) - pmid:24653673 + pubmed:21460840 - path(MESH:"Alzheimer Disease") negativeCorrelation complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs3764650) - pmid:24653673 + pubmed:21460840 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph)) + path(MESH:"Alzheimer Disease") association g(HGNC:MS4A1) - pmid:8282104 + pubmed:18823527 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph)) + path(MESH:"Alzheimer Disease") association g(HGNC:LRAT) - pmid:24027553 + pubmed:18823527 - path(MESH:"Alzheimer Disease") regulates p(HGNC:MAPT, pmod(Ph)) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs201825) - pmid:29191965 + pubmed:18823527 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph)) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs727153) - pmid:29191965 + pubmed:19734902 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph)) + path(MESH:"Alzheimer Disease") association g(HGNC:PICALM) - pmid:29311797 + pubmed:21627779 - path(MESH:"Alzheimer Disease") association p(HGNC:MAPT, pmod(Ph)) + path(MESH:"Alzheimer Disease") association g(HGNC:PICALM) - pmid:26458742 + pubmed:21460841 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph)) + path(MESH:"Alzheimer Disease") association g(HGNC:PICALM) - pmid:26631930 + pubmed:21379329 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph)) + path(MESH:"Alzheimer Disease") association g(HGNC:PICALM) - pmid:26631930 + pubmed:19734902 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph)) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs3851179) - pmid:22817713 + pubmed:21379329 - path(MESH:"Alzheimer Disease") increases p(HGNC:MAPT, pmod(Ph)) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs3851179) - pmid:12428809 + pubmed:19734902 - path(MESH:"Alzheimer Disease") association a(HBP:"straight filaments") + path(MESH:"Alzheimer Disease") association g(HGNC:APOE) - pmid:12428809 + pubmed:19734903 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HBP:"4R tau") + path(MESH:"Alzheimer Disease") association g(HGNC:APOE) - pmid:26631930 + pubmed:20460622 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HBP:"4R tau") + path(MESH:"Alzheimer Disease") association g(HGNC:APOE) - pmid:12428809 + pubmed:20885792 - path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"axonal transport") + path(MESH:"Alzheimer Disease") association g(HGNC:APOE) - pmid:22908190 + pubmed:17474819 - path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"axonal transport") + path(MESH:"Alzheimer Disease") association g(HGNC:APOE) - pmid:12428809 + pubmed:21123754 - path(MESH:"Alzheimer Disease") association p(HGNC:MAPT, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) + path(MESH:"Alzheimer Disease") association g(HGNC:APOE) - pmid:21882945 + pubmed:10936883 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) + path(MESH:"Alzheimer Disease") association g(HGNC:APOE) - pmid:22299660 + pubmed:19293145 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 198)) + path(MESH:"Alzheimer Disease") positiveCorrelation g(HGNC:APOE) - pmid:23088643 + pubmed:19734902 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 198)) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs2075650) - pmid:22299660 + pubmed:20460622 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 199)) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs2075650) - pmid:26458742 + pubmed:20061627 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 199)) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs2075650) - pmid:23088643 + pubmed:20885792 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 199)) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs2075650) - pmid:22299660 + pubmed:21123754 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs2075650) - pmid:29191965 + pubmed:19734902 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) + path(MESH:"Alzheimer Disease") association g(HGNC:CLU) - pmid:23088643 + pubmed:19734903 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) + path(MESH:"Alzheimer Disease") association g(HGNC:CLU) - pmid:22299660 + pubmed:21627779 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) + path(MESH:"Alzheimer Disease") association g(HGNC:CLU) - pmid:22419736 + pubmed:21460841 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) + path(MESH:"Alzheimer Disease") association g(HGNC:CLU) - pmid:28420982 + pubmed:21379329 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) + path(MESH:"Alzheimer Disease") association g(HGNC:CLU) - pmid:26458742 + pubmed:" 26517285" - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) + path(MESH:"Alzheimer Disease") increases g(HGNC:CLU) - pmid:22299660 + pubmed:19734902 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 404)) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs11136000) - pmid:22419736 + pubmed:19734903 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 404)) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs11136000) - pmid:26458742 + pubmed:21379329 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 404)) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs11136000) - pmid:22299660 + pubmed:21543606 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422)) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs11136000) - pmid:29191965 + pubmed:19734903 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422)) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs6656401) - pmid:26751493 + pubmed:19136949 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422)) + path(MESH:"Alzheimer Disease") association g(HGNC:PCDH11X) - pmid:27373205 + pubmed:19136949 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422)) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs5984894) - pmid:23088643 + pubmed:19118814 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422)) + path(MESH:"Alzheimer Disease") association g(HGNC:FAM13B) - pmid:22299660 + pubmed:19118814 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs11610206) - pmid:29758300 + pubmed:18976728 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs11159647) - pmid:26751493 + pubmed:18976728 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs4420638) - pmid:22299660 + pubmed:17474819 - path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:PPP2C) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs4420638) - pmid:22299660 + pubmed:17975299 - path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:PPP2C, pmod(Me, Leu, 309)) + path(MESH:"Alzheimer Disease") association g(HGNC:SORL1) - pmid:22299660 + pubmed:22005931 - path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:ICMT) + path(MESH:"Alzheimer Disease") association g(HGNC:DCHS2) - pmid:22299660 + pubmed:22005931 - path(MESH:"Alzheimer Disease") positiveCorrelation p(FPLX:PPP2C, pmod(Ph, Tyr, 307)) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs1466662) - pmid:21722302 + pubmed:21627779 - path(MESH:"Alzheimer Disease") association path(HBP:Neurodegeneration) + path(MESH:"Alzheimer Disease") association g(HGNC:BIN1) - pmid:21722302 + pubmed:21460841 - path(MESH:"Alzheimer Disease") association bp(HBP:"protein aggregation") + path(MESH:"Alzheimer Disease") association g(HGNC:BIN1) - pmid:21722302 + pubmed:21390209 - path(MESH:"Alzheimer Disease") association path(HP:"Senile plaques") + path(MESH:"Alzheimer Disease") association g(HGNC:BIN1) - pmid:21722302 + pubmed:21379329 - path(MESH:"Alzheimer Disease") association p(PFAM:Presenilin, var("?")) + path(MESH:"Alzheimer Disease") association g(HGNC:BIN1) - pmid:21722302 + pubmed:21627779 - path(MESH:"Alzheimer Disease") increases p(MESH:"Presenilin-1") + path(MESH:"Alzheimer Disease") association g(DBSNP:rs744373) - pmid:21722302 + pubmed:21390209 - path(MESH:"Alzheimer Disease") negativeCorrelation p(MESH:"molecular chaperone GRP78") + path(MESH:"Alzheimer Disease") association g(DBSNP:rs744373) - pmid:21722302 + pubmed:21627779 - path(MESH:"Alzheimer Disease") association p(HGNC:XBP1) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs569214) - pmid:21722302 + pubmed:21627779 - path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:XBP1) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs536841) - pmid:21722302 + pubmed:21627779 - path(MESH:"Alzheimer Disease") decreases bp(MESH:"Unfolded Protein Response") + path(MESH:"Alzheimer Disease") association g(DBSNP:rs1562990) - pmid:21722302 + pubmed:20061627 - path(MESH:"Alzheimer Disease") association a(GO:autophagosome) + path(MESH:"Alzheimer Disease") association g(HGNC:TOMM40) - pmid:29758300 + pubmed:21123754 - path(MESH:"Alzheimer Disease") increases a(GO:autophagosome) + path(MESH:"Alzheimer Disease") association g(HGNC:TOMM40) - pmid:22908190 + pubmed:21460841 - path(MESH:"Alzheimer Disease") positiveCorrelation a(GO:autophagosome) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs5616655) - pmid:18930136 + pubmed:21460841 - path(MESH:"Alzheimer Disease") positiveCorrelation a(GO:autophagosome) + path(MESH:"Alzheimer Disease") association g(HGNC:MS4A4A) - pmid:18930136 + pubmed:21460841 - path(MESH:"Alzheimer Disease") positiveCorrelation a(GO:autophagosome) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs4938933) - pmid:21722302 + pubmed:21460841 - path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:autophagy) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs7561528) - pmid:29758300 + pubmed:21379329 - path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:autophagy) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs7561528) - pmid:22908190 + pubmed:21460841 - path(MESH:"Alzheimer Disease") association bp(GO:autophagy) + path(MESH:"Alzheimer Disease") association g(HGNC:CR1) - pmid:22908190 + pubmed:21460841 - path(MESH:"Alzheimer Disease") association bp(GO:autophagy) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs6701713) - pmid:25437566 + pubmed:21460841 - path(MESH:"Alzheimer Disease") decreases p(HGNC:HSP90AB1) + path(MESH:"Alzheimer Disease") association g(HGNC:CD2AP) - pmid:25437566 + pubmed:21460841 - path(MESH:"Alzheimer Disease") decreases p(HGNC:HSPA8) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs9349407) - pmid:25437566 + pubmed:21460841 - path(MESH:"Alzheimer Disease") decreases p(HGNC:HSPA14) + path(MESH:"Alzheimer Disease") association g(HGNC:EPHA1) - pmid:25437566 + pubmed:21460841 - path(MESH:"Alzheimer Disease") decreases p(HGNC:TCP1) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs11767557) - pmid:27491084 + pubmed:21460841 - path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") + path(MESH:"Alzheimer Disease") association g(DBSNP:rs1532278) - pmid:27491084 + pubmed:21390209 - path(MESH:"Alzheimer Disease") increases p(HGNC:HSPB1) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs12989701) - pmid:27491084 + pubmed:21379329 - path(MESH:"Alzheimer Disease") increases p(HGNC:CRYAB) + path(MESH:"Alzheimer Disease") association g(HGNC:CELF2) - pmid:27491084 + pubmed:21379329 - path(MESH:"Alzheimer Disease") increases p(FPLX:HSPB) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs201119) - pmid:29758300 + pubmed:20885792 - path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:macroautophagy) + path(MESH:"Alzheimer Disease") association g(HGNC:MTHFD1L) - pmid:29758300 + pubmed:20885792 - path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:macroautophagy) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs11754661) - pmid:29758300 + pubmed:17553421 - path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:macroautophagy) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs2373115) - pmid:29758300 + pubmed:21123754 - path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:macroautophagy) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs429358) - pmid:25784053 + pubmed:21123754 - path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:macroautophagy) + path(MESH:"Alzheimer Disease") association g(HGNC:EPC2) - pmid:29758300 + pubmed:21123754 - path(MESH:"Alzheimer Disease") increases complex(a(GO:autophagosome), a(HBP:"dystrophic neurite")) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs4499362) - pmid:29758300 + pubmed:21123754 - path(MESH:"Alzheimer Disease") positiveCorrelation a(GO:autolysosome) + path(MESH:"Alzheimer Disease") association g(HGNC:CCDC134) - pmid:23528736 + pubmed:21123754 - path(MESH:"Alzheimer Disease") increases a(GO:autolysosome) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs7364180) - pmid:23528736 + pubmed:23022416 - path(MESH:"Alzheimer Disease") increases a(GO:autolysosome) + path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs3818361) - pmid:29758300 + pubmed:23022416 - path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"lysosomal protein catabolic process") + path(MESH:"Alzheimer Disease") association composite(g(DBSNP:rs3818361), g(DBSNP:rs429358)) - pmid:22908190 + pubmed:22236693 - path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"lysosomal protein catabolic process") + path(MESH:"Alzheimer Disease") negativeCorrelation g(DBSNP:rs2072446) - pmid:23528736 + pubmed:22236693 - path(MESH:"Alzheimer Disease") decreases bp(GO:"lysosomal protein catabolic process") + path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs2072446) - pmid:29758300 + pubmed:22236693 - path(MESH:"Alzheimer Disease") association p(HGNC:PSEN1, var("?")) + path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs741072) - pmid:29758300 + pubmed:22236693 - path(MESH:"Alzheimer Disease") increases a(GO:lysosome) + path(MESH:"Alzheimer Disease") negativeCorrelation g(DBSNP:rs734194) - pmid:22908190 + pubmed:22236693 - path(MESH:"Alzheimer Disease") positiveCorrelation a(GO:lysosome) + path(MESH:"Alzheimer Disease") negativeCorrelation g(DBSNP:rs734194) - pmid:22908190 + pubmed:29183403 - path(MESH:"Alzheimer Disease") negativeCorrelation act(a(GO:lysosome)) + path(MESH:"Alzheimer Disease") negativeCorrelation g(DBSNP:rs142787485) - pmid:29758300 + pubmed:29183403 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SNCA) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:RAB10) - pmid:29758300 + pubmed:21709374 - path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:endocytosis) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs1050283) - pmid:22908190 + pubmed:18191876 - path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:endocytosis) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs1050283) - pmid:22908190 + pubmed:18191876 - path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:endocytosis) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs12316150) - pmid:29758300 + pubmed:19660836 - path(MESH:"Alzheimer Disease") association a(HBP:"alpha-synuclein aggregates") + path(MESH:"Alzheimer Disease") negativeCorrelation g(DBSNP:rs4135263) - pmid:29758300 + pubmed:19660836 - path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"alpha-synuclein aggregates") + path(MESH:"Alzheimer Disease") negativeCorrelation g(DBSNP:rs1151999) - pmid:29758300 + pubmed:19660836 - path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:ceramide) + path(MESH:"Alzheimer Disease") negativeCorrelation g(DBSNP:rs709149) - pmid:29758300 + pubmed:19660836 - path(MESH:"Alzheimer Disease") association p(HGNC:TFEB) + path(MESH:"Alzheimer Disease") negativeCorrelation g(DBSNP:rs709154) - pmid:29758300 + pubmed:19660836 - path(MESH:"Alzheimer Disease") association p(HGNC:PICALM, var("?")) + path(MESH:"Alzheimer Disease") association g(HGNC:PPARG) - pmid:26195256 + pubmed:19660836 - path(MESH:"Alzheimer Disease") association p(HGNC:PICALM, var("?")) + path(MESH:"Alzheimer Disease") negativeCorrelation g(HGNC:PPARG) - pmid:29758300 + pubmed:21548758 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:BIN1) + path(MESH:"Alzheimer Disease") association g(HGNC:HNRNPA1) - pmid:29758300 + pubmed:24162737 - path(MESH:"Alzheimer Disease") association p(HGNC:VPS35, var("?")) + path(MESH:"Alzheimer Disease") association g(HGNC:SQSTM1) - pmid:29758300 + pubmed:22005930 - path(MESH:"Alzheimer Disease") association p(HGNC:SORL1) + path(MESH:"Alzheimer Disease") association g(HGNC:STK11) - pmid:29758300 + pubmed:21390209 - path(MESH:"Alzheimer Disease") increases bp(GO:mitophagy) + path(MESH:"Alzheimer Disease") association g(HGNC:AGRN) - pmid:14556719 + pubmed:22020111 - path(MESH:"Alzheimer Disease") decreases bp(GO:"short-term memory") + path(MESH:"Alzheimer Disease") increases g(HGNC:AGRN) - pmid:14556719 + pubmed:19734902 - path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:UBA1)) + path(MESH:"Alzheimer Disease") association g(HGNC:MIR146A) - pmid:14556719 + pubmed:24586483 - path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:UBA2)) + path(MESH:"Alzheimer Disease") association g(HGNC:MIR146A) - pmid:14556719 + pubmed:19734902 - path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + path(MESH:"Alzheimer Disease") association g(HGNC:CSF3R) - pmid:23528736 + pubmed:19734902 - path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + path(MESH:"Alzheimer Disease") association g(HGNC:DAB2) - pmid:29626319 + pubmed:19734902 - path(MESH:"Alzheimer Disease") decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + path(MESH:"Alzheimer Disease") association g(HGNC:DAB1) - pmid:22908190 + pubmed:19734902 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:PRKN) + path(MESH:"Alzheimer Disease") association g(HGNC:BTBD3) - pmid:23528736 + pubmed:19734902 - path(MESH:"Alzheimer Disease") association p(HGNC:PRKN) + path(MESH:"Alzheimer Disease") association g(HGNC:SKAP2) - pmid:22908190 + pubmed:19734902 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ub)) + path(MESH:"Alzheimer Disease") association g(HGNC:NAV3) - pmid:22908190 + pubmed:19734902 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HBP:"UBB+1") + path(MESH:"Alzheimer Disease") association g(HGNC:MKI67) - pmid:23528736 + pubmed:19734902 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HBP:"UBB+1") + path(MESH:"Alzheimer Disease") association g(HGNC:ANXA1) - pmid:22908190 + pubmed:19734902 - path(MESH:"Alzheimer Disease") association p(HGNC:UCHL1) + path(MESH:"Alzheimer Disease") association g(HGNC:SPTLC1) - pmid:22908190 + pubmed:19734902 - path(MESH:"Alzheimer Disease") association p(HGNC:UBQLN1) + path(MESH:"Alzheimer Disease") association g(HGNC:GRIN3A) - pmid:22908190 + pubmed:19734902 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:UBQLN1, var("?")) + path(MESH:"Alzheimer Disease") association g(HGNC:STIM2) - pmid:22908190 + pubmed:19734902 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:RAB7A) + path(MESH:"Alzheimer Disease") association g(HGNC:GRIK2) - pmid:22908190 + pubmed:19734902 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:RAB5A) + path(MESH:"Alzheimer Disease") association g(HGNC:ROBO2) - pmid:22908190 + pubmed:19734902 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:RAB4A) + path(MESH:"Alzheimer Disease") association g(HGNC:RYR2) - pmid:22908190 + pubmed:19734902 - path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"dystrophic neurite") + path(MESH:"Alzheimer Disease") association g(HGNC:FOXO3) - pmid:22908190 + pubmed:19734902 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:APP, var("?")) + path(MESH:"Alzheimer Disease") association g(HGNC:SLC25A21) - pmid:22908190 + pubmed:19734902 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:APP, var("?")) + path(MESH:"Alzheimer Disease") association g(HGNC:RELN) - pmid:22908190 + pubmed:19734902 - path(MESH:"Alzheimer Disease") association g(HBP:"APOE e4") + path(MESH:"Alzheimer Disease") association g(HGNC:GRIK4) - pmid:25784053 + pubmed:19734902 - path(MESH:"Alzheimer Disease") negativeCorrelation act(p(FPLX:Proteasome)) + path(MESH:"Alzheimer Disease") association g(HGNC:APBA1) - pmid:8282104 + pubmed:19734902 - path(MESH:"Alzheimer Disease") positiveCorrelation p(FPLX:ERK) + path(MESH:"Alzheimer Disease") association g(HGNC:RYR3) - pmid:8282104 + pubmed:19734902 - path(MESH:"Alzheimer Disease") positiveCorrelation p(FPLX:GSK3) + path(MESH:"Alzheimer Disease") association g(HGNC:ATP2A3) - pmid:30116051 + pubmed:23535033 - path(MESH:"Alzheimer Disease") decreases p(HGNC:SIRT1) + path(MESH:"Alzheimer Disease") association g(HGNC:CAMK4) - pmid:30116051 + pubmed:23535033 - path(MESH:"Alzheimer Disease") positiveCorrelation g(HGNC:PSEN1, var("?")) + path(MESH:"Alzheimer Disease") association g(HGNC:CYCS) - pmid:26195256 + pubmed:22107728 - path(MESH:"Alzheimer Disease") association g(HGNC:PSEN1, var("?")) + path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs4646953) - pmid:30116051 + pubmed:23279143 - path(MESH:"Alzheimer Disease") negativeCorrelation a(CHEBI:"selenium(2+)") + path(MESH:"Alzheimer Disease") association p(HGNC:SORCS1) - pmid:30116051 + pubmed:23279143 - path(MESH:"Alzheimer Disease") increases act(p(HGNC:ABL1)) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs7907690) - pmid:30116051 + pubmed:23279143 - path(MESH:"Alzheimer Disease") decreases p(HGNC:MME) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs7907690) - pmid:30116051 + pubmed:23279143 - path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PLG) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs601883) - pmid:29024336 + pubmed:23279143 - path(MESH:"Alzheimer Disease") increases path(MESH:"Proteostasis Deficiencies") + path(MESH:"Alzheimer Disease") association g(DBSNP:rs17277986) - pmid:29215007 + pubmed:23279143 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, var("?")) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs2900717) - pmid:24027553 + pubmed:23279143 - path(MESH:"Alzheimer Disease") association p(HGNC:PIN1) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs10884399) - pmid:24027553 + pubmed:23279143 - path(MESH:"Alzheimer Disease") increases a(CHEBI:Thrombin, loc(MESH:Microvessels)) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs11193170) - pmid:24027553 + pubmed:23279143 - path(MESH:"Alzheimer Disease") increases a(CHEBI:Thrombin, loc(MESH:"Cerebrospinal Fluid")) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs4918280) - pmid:24027553 + pubmed:23279143 - path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:Thrombin, loc(MESH:Neurons)) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs600879) - pmid:24027553 + pubmed:23403532 - path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:Thrombin, loc(MESH:Astrocytes)) + path(MESH:"Alzheimer Disease") association complex(p(HGNC:NRXN1), p(INTERPRO:Neuroligin)) - pmid:24027553 + pubmed:23403532 - path(MESH:"Alzheimer Disease") association bp(HBP:"APP processing") + path(MESH:"Alzheimer Disease") association complex(p(HGNC:NRXN2), p(INTERPRO:Neuroligin)) - pmid:24027553 + pubmed:23403532 - path(MESH:"Alzheimer Disease") increases act(p(HGNC:CAPN2)) + path(MESH:"Alzheimer Disease") association complex(p(HGNC:NRXN3), p(INTERPRO:Neuroligin)) - pmid:24027553 + pubmed:21036197 - path(MESH:"Alzheimer Disease") positiveCorrelation act(p(HGNC:CASP3)) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs411280) - pmid:24027553 + pubmed:24586483 - path(MESH:"Alzheimer Disease") positiveCorrelation act(p(HGNC:CASP6)) + path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs57095329) - pmid:24027553 + pubmed:25038421 - path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"proteasomal protein catabolic process") + path(MESH:"Alzheimer Disease") association g(DBSNP:rs998382) - pmid:24027553 + pubmed:25038421 - path(MESH:"Alzheimer Disease") increases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Proteasome)) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs2424913) - pmid:24027553 + pubmed:22691691 - path(MESH:"Alzheimer Disease") positiveCorrelation a(MESH:Autophagosomes) + path(MESH:"Alzheimer Disease") association p(HGNC:DRD4) - pmid:23528736 + pubmed:" 26517285" - path(MESH:"Alzheimer Disease") increases a(MESH:Autophagosomes) + path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"microglial cell activation") - pmid:23528736 + pubmed:28877763 - path(MESH:"Alzheimer Disease") increases a(MESH:Autophagosomes) + path(MESH:"Alzheimer Disease") increases bp(GO:"microglial cell activation") - pmid:24027553 + pubmed:25687773 - path(MESH:"Alzheimer Disease") positiveCorrelation a(MESH:Lysosomes) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs393152) - pmid:24027553 + pubmed:25687773 - path(MESH:"Alzheimer Disease") decreases bp(MESH:Autophagy) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs393152) - pmid:27574109 + pubmed:25687773 - path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"3R tau") + path(MESH:"Alzheimer Disease") association path(MESH:Atrophy) - pmid:27574109 + pubmed:18986241 - path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"4R tau") + path(MESH:"Alzheimer Disease") increases path(MESH:Atrophy) - pmid:27574109 + pubmed:26195256 - path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"phosphatase-activating domain") + path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:Atrophy) - pmid:27574109 + pubmed:26195256 - path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"Tau oligomers") + path(MESH:"Alzheimer Disease") decreases path(MESH:Atrophy) - pmid:27574109 + pubmed:19419557 - path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"Tau oligomers") + path(MESH:"Alzheimer Disease") decreases p(HGNC:GRIN1) - pmid:25887395 + pubmed:19419557 - path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"Tau oligomers") + path(MESH:"Alzheimer Disease") decreases p(HGNC:GRIN2A) - pmid:28420982 + pubmed:19419557 - path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"Tau oligomers") + path(MESH:"Alzheimer Disease") decreases p(HGNC:GRIN2B) - pmid:26631930 + pubmed:19419557 - path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"Tau oligomers") + path(MESH:"Alzheimer Disease") association p(HGNC:CALHM1, var("p.Pro86Leu")) - pmid:22817713 + pubmed:23556446 - path(MESH:"Alzheimer Disease") increases a(HBP:"Tau oligomers") + path(MESH:"Alzheimer Disease") association p(HGNCGENEFAMILY:"ATP binding cassette subfamily A") - pmid:27574109 + pubmed:23556446 - path(MESH:"Alzheimer Disease") positiveCorrelation composite(a(HBP:"phosphatase-activating domain"), p(HGNC:MAPT)) + path(MESH:"Alzheimer Disease") association g(DBSNP:rs3752246) - pmid:21734277 + pubmed:23556446 - path(MESH:"Alzheimer Disease") increases p(HBP:"phosphatase-activating domain") + path(MESH:"Alzheimer Disease") association g(DBSNP:rs3740066) - pmid:21734277 + pubmed:23556446 - path(MESH:"Alzheimer Disease") increases p(HBP:"phosphatase-activating domain") + path(MESH:"Alzheimer Disease") association p(HGNC:ABCC2) - pmid:23528736 + pubmed:23556446 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:UBB) + path(MESH:"Alzheimer Disease") association p(HGNC:ABCC2, var("p.Cys3972Thr")) - pmid:23528736 + pubmed:20100581 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:UBC) + path(MESH:"Alzheimer Disease") association a(NIFT:"Grey matter volume") - pmid:23528736 + pubmed:20100581 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:UBA52) + path(MESH:"Alzheimer Disease") association p(HGNC:NXPH1) - pmid:23528736 + pubmed:16151770 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:RPS27A) + path(MESH:"Alzheimer Disease") negativeCorrelation a(NIFT:"Cerebral blood flow") - pmid:23528736 + pubmed:23300102 - path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNCGENEFAMILY:"Ubiquitin like modifier activating enzymes") + path(MESH:"Alzheimer Disease") negativeCorrelation a(NIFT:"Cerebral blood flow") - pmid:23528736 + pubmed:23300102 - path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNCGENEFAMILY:"Ubiquitin conjugating enzymes E2") + path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"glucose metabolic process") - pmid:23528736 + pubmed:26195256 - path(MESH:"Alzheimer Disease") association p(HGNC:STUB1) + path(MESH:"Alzheimer Disease") decreases bp(GO:"glucose metabolic process") - pmid:29311797 + pubmed:26836182 - path(MESH:"Alzheimer Disease") association p(HGNC:STUB1) + path(MESH:"Alzheimer Disease") positiveCorrelation path(CONSO:neuroinflammation) - pmid:23528736 + pubmed:22550605 - path(MESH:"Alzheimer Disease") association p(HGNC:RNF182) + path(MESH:"Alzheimer Disease") association p(HGNC:TOMM40, var("?")) - pmid:23528736 + pubmed:26996954 - path(MESH:"Alzheimer Disease") association p(HGNC:UCHL1, var("?")) + path(MESH:"Alzheimer Disease") increases p(HGNC:APP, frag("672_713")) - pmid:23528736 + pubmed:14970312 - path(MESH:"Alzheimer Disease") decreases bp(MESH:Proteolysis) + path(MESH:"Alzheimer Disease") increases p(HGNC:APP, frag("672_713")) - pmid:29988016 + pubmed:21543606 - path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"Tau aggregates") + path(MESH:"Alzheimer Disease") decreases a(NIFT:"White matter") - pmid:27373205 + pubmed:14970312 - path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"Tau aggregates") + path(MESH:"Alzheimer Disease") association bp(MESH:"Oxidative Stress") - pmid:26631930 + pubmed:22020111 - path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"Tau aggregates") + path(MESH:"Alzheimer Disease") positiveCorrelation bp(MESH:"Oxidative Stress") - pmid:22817713 + pubmed:14970312 - path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"Tau aggregates") + path(MESH:"Alzheimer Disease") association bp(GO:"sphingolipid metabolic process") - pmid:21882945 + pubmed:14970312 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) + path(MESH:"Alzheimer Disease") association bp(GO:"cholesterol metabolic process") - pmid:21882945 + pubmed:30061532 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:BAG1) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:30126037 + pubmed:30145931 - path(MESH:"Alzheimer Disease") association bp(MESH:"Cerebrovascular Circulation") + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:22419736 + pubmed:17403556 - path(MESH:"Alzheimer Disease") increases p(HGNC:AK1) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:22419736 + pubmed:25374103 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:AK1) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:22419736 + pubmed:26631930 - path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:AMPK, pmod(Ph, Thr, 172)) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:29191965 + pubmed:24401760 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 205)) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:30985105 + pubmed:19126755 - path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:OGT)) + path(MESH:"Alzheimer Disease") negativeCorrelation p(CONSO:"alpha-4 beta-2 nAChR") - pmid:30985105 + pubmed:19126755 - path(MESH:"Alzheimer Disease") decreases p(HGNC:OGT) + path(MESH:"Alzheimer Disease") negativeCorrelation p(CONSO:"alpha-4 beta-2 nAChR") - pmid:25374103 + pubmed:19293145 - path(MESH:"Alzheimer Disease") decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + path(MESH:"Alzheimer Disease") association p(CONSO:"alpha-4 beta-2 nAChR") - pmid:25374103 + pubmed:19721446 - path(MESH:"Alzheimer Disease") decreases p(HGNC:MAPT, pmod(HBP:misfolded)) + path(MESH:"Alzheimer Disease") decreases p(CONSO:"alpha-4 beta-2 nAChR") - pmid:28877763 + pubmed:19126755 - path(MESH:"Alzheimer Disease") increases bp(GO:"microglial cell activation") + path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:28420982 + pubmed:19126755 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 181)) + path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:29311797 + pubmed:19126755 - path(MESH:"Alzheimer Disease") isA path(MESH:Tauopathies) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:29311797 + pubmed:19293145 - path(MESH:"Alzheimer Disease") decreases p(HGNC:PPID) + path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:29311797 + pubmed:19293145 - path(MESH:"Alzheimer Disease") increases p(HGNC:FKBP5) + path(MESH:"Alzheimer Disease") decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:29311797 + pubmed:19293145 - path(MESH:"Alzheimer Disease") decreases p(HGNC:FKBP4) + path(MESH:"Alzheimer Disease") association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:29311797 + pubmed:19293145 - path(MESH:"Alzheimer Disease") decreases act(p(HGNC:PPP5C)) + path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:29311797 + pubmed:19293145 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:AHSA1) + path(MESH:"Alzheimer Disease") increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:26751493 + pubmed:24590577 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 18)) + path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:26631930 + pubmed:19721446 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 18)) + path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:26751493 + pubmed:19126755 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 68)) + path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:CHRNA7) - pmid:26751493 + pubmed:19293145 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 69)) + path(MESH:"Alzheimer Disease") association p(HGNC:CHRNA7) - pmid:26751493 + pubmed:19293145 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 71)) + path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA7) - pmid:26751493 + pubmed:19293145 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 113)) + path(MESH:"Alzheimer Disease") increases p(HGNC:CHRNA7) - pmid:26751493 + pubmed:19293145 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 123)) + path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA7) - pmid:26751493 + pubmed:19293145 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 153)) + path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA7) - pmid:26751493 + pubmed:11230871 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 175)) + path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:CHRNA7) - pmid:26751493 + pubmed:22040696 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 184)) + path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:CHRNA7) - pmid:26751493 + pubmed:29191965 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 185)) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:CHRNA7) - pmid:26751493 + pubmed:19126755 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 191)) + path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:Dementia) - pmid:26751493 + pubmed:19293145 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 197)) + path(MESH:"Alzheimer Disease") association path(MESH:Dementia) - pmid:23088643 + pubmed:24511233 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 197)) + path(MESH:"Alzheimer Disease") association path(MESH:Dementia) - pmid:26751493 + pubmed:25514383 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 208)) + path(MESH:"Alzheimer Disease") association path(MESH:Dementia) - pmid:26751493 + pubmed:21718217 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 210)) + path(MESH:"Alzheimer Disease") increases path(MESH:Dementia) - pmid:26751493 + pubmed:14556719 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 214)) + path(MESH:"Alzheimer Disease") increases path(MESH:Dementia) - pmid:26751493 + pubmed:19126755 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 237)) + path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"synaptic transmission, cholinergic") - pmid:26751493 + pubmed:24511233 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 238)) + path(MESH:"Alzheimer Disease") decreases bp(GO:"synaptic transmission, cholinergic") - pmid:26751493 + pubmed:24511233 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 258)) + path(MESH:"Alzheimer Disease") decreases bp(GO:"synaptic transmission, cholinergic") - pmid:26751493 + pubmed:26813123 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 289)) + path(MESH:"Alzheimer Disease") association bp(GO:"synaptic transmission, cholinergic") - pmid:26751493 + pubmed:24590577 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 356)) + path(MESH:"Alzheimer Disease") decreases bp(GO:"synaptic transmission, cholinergic") - pmid:26751493 + pubmed:19126755 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 394)) + path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Neurofibrillary Tangles") - pmid:26631930 + pubmed:24590577 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 394)) + path(MESH:"Alzheimer Disease") association path(MESH:"Neurofibrillary Tangles") - pmid:26751493 + pubmed:24027553 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 403)) + path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Neurofibrillary Tangles") - pmid:26751493 + pubmed:19126755 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 409)) + path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Neurogenic Inflammation") - pmid:26751493 + pubmed:19126755 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 435)) + path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:CHRNA4) - pmid:26751493 + pubmed:19293145 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 427)) + path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA4) - pmid:26751493 + pubmed:19293145 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 433)) + path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA4) - pmid:26195256 + pubmed:19293145 - path(MESH:"Alzheimer Disease") association g(HGNC:PSEN2, var("?")) + path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA4) - pmid:26195256 + pubmed:11230871 - path(MESH:"Alzheimer Disease") association g(HGNC:APP, var("?")) + path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:CHRNA4) - pmid:26195256 + pubmed:19293145 - path(MESH:"Alzheimer Disease") association p(HGNC:TREM2, var("?")) + path(MESH:"Alzheimer Disease") decreases bp(GO:memory) - pmid:26195256 + pubmed:24511233 - path(MESH:"Alzheimer Disease") association p(HGNC:CLU, var("?")) + path(MESH:"Alzheimer Disease") decreases bp(GO:memory) - pmid:26195256 + pubmed:24511233 - path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:Atrophy) + path(MESH:"Alzheimer Disease") decreases bp(GO:memory) - pmid:26195256 + pubmed:22040696 - path(MESH:"Alzheimer Disease") decreases path(MESH:Atrophy) + path(MESH:"Alzheimer Disease") decreases bp(GO:memory) - pmid:26195256 + pubmed:19293145 - path(MESH:"Alzheimer Disease") negativeCorrelation a(MESH:"Cerebral Cortex") + path(MESH:"Alzheimer Disease") decreases path(MESH:"Psychomotor Performance") - pmid:26195256 + pubmed:19293145 - path(MESH:"Alzheimer Disease") positiveCorrelation a(MESH:"Cerebral Ventricles") + path(MESH:"Alzheimer Disease") association path(MESH:Death) - pmid:26195256 + pubmed:19293145 - path(MESH:"Alzheimer Disease") decreases bp(GO:"glucose metabolic process") + path(MESH:"Alzheimer Disease") positiveCorrelation a(MESH:"Neurofibrillary Tangles") - pmid:26195256 + pubmed:18986241 - path(MESH:"Alzheimer Disease") negativeCorrelation p(MESH:Neprilysin) + path(MESH:"Alzheimer Disease") association a(MESH:"Neurofibrillary Tangles") - pmid:26195256 + pubmed:18986241 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MMP2) + path(MESH:"Alzheimer Disease") increases a(MESH:"Neurofibrillary Tangles") - pmid:26195256 + pubmed:14556719 - path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:LRP1) + path(MESH:"Alzheimer Disease") increases a(MESH:"Neurofibrillary Tangles") - pmid:26195256 + pubmed:19293145 - path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:ABCB1) + path(MESH:"Alzheimer Disease") association a(CONSO:"amyloid-beta aggregates") - pmid:29626319 + pubmed:25514383 - path(MESH:"Alzheimer Disease") decreases p(HGNC:ABCB1) + path(MESH:"Alzheimer Disease") positiveCorrelation a(CONSO:"amyloid-beta aggregates") - pmid:26195256 + pubmed:26195256 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:AGER) + path(MESH:"Alzheimer Disease") increases a(CONSO:"amyloid-beta aggregates") - pmid:26195256 + pubmed:22817713 - path(MESH:"Alzheimer Disease") negativeCorrelation bp(HBP:"perivascular drainage pathways") + path(MESH:"Alzheimer Disease") positiveCorrelation a(CONSO:"amyloid-beta aggregates") - pmid:26195256 + pubmed:19293145 - path(MESH:"Alzheimer Disease") negativeCorrelation a(MESH:"Cerebrospinal Fluid") + path(MESH:"Alzheimer Disease") increases p(HGNC:BCHE) - pmid:26195256 + pubmed:18986241 - path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:AQP1)) + path(MESH:"Alzheimer Disease") increases act(p(HGNC:BCHE)) - pmid:26195256 + pubmed:19293145 - path(MESH:"Alzheimer Disease") increases path(MESH:"Calcification, Physiologic") + path(MESH:"Alzheimer Disease") decreases act(p(HGNC:CHAT)) - pmid:26195256 + pubmed:19293145 - path(MESH:"Alzheimer Disease") increases path(MESH:Fibrosis) + path(MESH:"Alzheimer Disease") decreases act(p(HGNC:CHAT)) - pmid:26631930 + pubmed:26813123 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HBP:"3R tau") + path(MESH:"Alzheimer Disease") decreases act(p(HGNC:CHAT)) - pmid:26631930 + pubmed:24590577 - path(MESH:"Alzheimer Disease") decreases p(HGNC:MAPT, pmod(Ac, Lys, 259)) + path(MESH:"Alzheimer Disease") decreases p(HGNC:CHAT) - pmid:26631930 + pubmed:25514383 - path(MESH:"Alzheimer Disease") decreases p(HGNC:MAPT, pmod(Ac, Lys, 290)) + path(MESH:"Alzheimer Disease") decreases act(p(HGNC:CHAT)) - pmid:26631930 + pubmed:18986241 - path(MESH:"Alzheimer Disease") decreases p(HGNC:MAPT, pmod(Ac, Lys, 321)) + path(MESH:"Alzheimer Disease") decreases p(HGNC:CHAT) - pmid:26631930 + pubmed:19293145 - path(MESH:"Alzheimer Disease") decreases p(HGNC:MAPT, pmod(Ac, Lys, 353)) + path(MESH:"Alzheimer Disease") decreases act(a(MESH:"Cholinesterase Inhibitors")) - pmid:26631930 + pubmed:19293145 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 280)) + path(MESH:"Alzheimer Disease") association g(HGNC:CHAT) - pmid:29276758 + pubmed:19293145 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 280)) + path(MESH:"Alzheimer Disease") association g(HGNC:ACHE) - pmid:21427723 + pubmed:19293145 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 280)) + path(MESH:"Alzheimer Disease") increases p(HGNC:FYN) - pmid:26631930 + pubmed:19293145 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 174)) + path(MESH:"Alzheimer Disease") increases p(HGNC:FYN) - pmid:26631930 + pubmed:19293145 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(NGlyco)) + path(MESH:"Alzheimer Disease") increases complex(p(HGNC:FYN), p(HGNC:MAPT)) - pmid:26631930 + pubmed:24653673 - path(MESH:"Alzheimer Disease") decreases p(HGNC:MAPT, pmod(OGlyco)) + path(MESH:"Alzheimer Disease") positiveCorrelation complex(p(HGNC:FYN), p(HGNC:MAPT)) - pmid:26631930 + pubmed:19293145 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) + path(MESH:"Alzheimer Disease") association act(p(HGNC:INS)) - pmid:26631930 + pubmed:19293145 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) + path(MESH:"Alzheimer Disease") association bp(GO:"regulation of cytosolic calcium ion concentration") - pmid:17050703 + pubmed:19293145 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) + path(MESH:"Alzheimer Disease") association p(HGNC:PSEN1) - pmid:26631930 + pubmed:21722302 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) + path(MESH:"Alzheimer Disease") increases p(HGNC:PSEN1) - pmid:26631930 + pubmed:19293145 - path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:MAPT, pmod(Me)) + path(MESH:"Alzheimer Disease") association bp(GO:learning) - pmid:26631930 + pubmed:24511233 - path(MESH:"Alzheimer Disease") increases p(HGNC:MAPT, frag("?")) + path(MESH:"Alzheimer Disease") decreases bp(GO:learning) - pmid:26631930 + pubmed:24511233 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, frag("26_230")) + path(MESH:"Alzheimer Disease") decreases bp(GO:learning) - pmid:26631930 + pubmed:19293145 - path(MESH:"Alzheimer Disease") increases a(CHEBI:"iron(0)") + path(MESH:"Alzheimer Disease") association path(MESH:"Cognitive Dysfunction") - pmid:22817713 + pubmed:24511233 - path(MESH:"Alzheimer Disease") association a(MESH:"Neuropil Threads") + path(MESH:"Alzheimer Disease") association path(MESH:"Cognitive Dysfunction") - pmid:29626319 + pubmed:24511233 - path(MESH:"Alzheimer Disease") decreases bp(GO:"lysosomal microautophagy") + path(MESH:"Alzheimer Disease") association path(MESH:"Cognitive Dysfunction") - pmid:29626319 + pubmed:26813123 - path(MESH:"Alzheimer Disease") positiveCorrelation act(p(HGNC:ACE)) + path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Cognitive Dysfunction") - pmid:29626319 + pubmed:27522251 - path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:SERPINF2) + path(MESH:"Alzheimer Disease") increases path(MESH:"Cognitive Dysfunction") - pmid:29626319 + pubmed:19293145 - path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:SERPINF2)) + path(MESH:"Alzheimer Disease") decreases a(MESH:"Cholinergic Neurons") - pmid:29626319 + pubmed:19293145 - path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PICALM) + path(MESH:"Alzheimer Disease") decreases a(MESH:"Cholinergic Neurons") - pmid:27260836 + pubmed:19293145 - path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PICALM) + path(MESH:"Alzheimer Disease") decreases a(MESH:"Cholinergic Neurons") - pmid:29626319 + pubmed:24511233 - path(MESH:"Alzheimer Disease") decreases tloc(a(CHEBI:water), fromLoc(GO:"extracellular region"), toLoc(MESH:"Cerebrospinal Fluid")) + path(MESH:"Alzheimer Disease") decreases a(MESH:"Cholinergic Neurons") - pmid:25974414 + pubmed:26813123 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, var("p.Asp13*")) + path(MESH:"Alzheimer Disease") negativeCorrelation a(MESH:"Cholinergic Neurons") - pmid:25974414 + pubmed:24590577 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, var("p.Asp25*")) + path(MESH:"Alzheimer Disease") decreases a(MESH:"Cholinergic Neurons") - pmid:25974414 + pubmed:24590577 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, var("p.Asp368*")) + path(MESH:"Alzheimer Disease") decreases a(MESH:"Cholinergic Neurons") - pmid:25974414 + pubmed:19293145 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, var("p.Glu391*")) + path(MESH:"Alzheimer Disease") decreases complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) - pmid:25974414 + pubmed:19293145 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, var("p.Asp421*")) + path(MESH:"Alzheimer Disease") decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) - pmid:24869773 + pubmed:21787755 - path(MESH:"Alzheimer Disease") association p(HGNC:MAPT, pmod(Me, Lys, 311)) + path(MESH:"Alzheimer Disease") association complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) - pmid:23531502 + pubmed:19293145 - path(MESH:"Alzheimer Disease") positiveCorrelation act(a(CHEBI:acrolein)) + path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA3) - pmid:19251756 + pubmed:19293145 - path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"canonical glycolysis") + path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA3) - pmid:19251756 + pubmed:19293145 - path(MESH:"Alzheimer Disease") negativeCorrelation a(CHEBI:ATP) + path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNA3) - pmid:19251756 + pubmed:11230871 - path(MESH:"Alzheimer Disease") positiveCorrelation p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 164)) + path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:CHRNA3) - pmid:19251756 + pubmed:11230871 - path(MESH:"Alzheimer Disease") positiveCorrelation p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 208)) + path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:CHRNA3) - pmid:11738469 + pubmed:11230871 - path(MESH:"Alzheimer Disease") positiveCorrelation act(p(ECCODE:"2.3.2.13")) + path(MESH:"Alzheimer Disease") causesNoChange p(HGNC:CHRNA3) - pmid:8985134 + pubmed:19293145 - path(MESH:"Alzheimer Disease") positiveCorrelation act(p(ECCODE:"2.3.2.13")) + path(MESH:"Alzheimer Disease") causesNoChange r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:9099822 + pubmed:19293145 - path(MESH:"Alzheimer Disease") increases act(p(HGNCGENEFAMILY:Transglutaminases)) + path(MESH:"Alzheimer Disease") decreases p(HGNC:CHRNB4) - pmid:20096481 + pubmed:19293145 - path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs2651206) + path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits") - pmid:21548880 + pubmed:19293145 - path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs2651206) + path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Glutamate ionotropic receptor AMPA type subunits") - pmid:20096481 + pubmed:19293145 - path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs10807287) + path(MESH:"Alzheimer Disease") decreases p(HGNC:GABRB3) - pmid:20096481 + pubmed:19293145 - path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs7764257) + path(MESH:"Alzheimer Disease") causesNoChange p(MGI:Chrna7) - pmid:11943212 + pubmed:25881725 - path(MESH:"Alzheimer Disease") positiveCorrelation path(HBP:"granulovacuolar degeneration") + path(MESH:"Alzheimer Disease") negativeCorrelation p(MGI:Chrna7) - pmid:23666762 + pubmed:19293145 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MARK4) + path(MESH:"Alzheimer Disease") causesNoChange p(MGI:Chrna4) - pmid:23666762 + pubmed:24511233 - path(MESH:"Alzheimer Disease") positiveCorrelation complex(p(HGNC:MAPT), p(HGNC:MARK4)) + path(MESH:"Alzheimer Disease") association path(MESH:"Psychotic Disorders") - pmid:28176663 + pubmed:24511233 - path(MESH:"Alzheimer Disease") increases r(HGNC:GSK3B) + path(MESH:"Alzheimer Disease") association path(MESH:"Psychotic Disorders") - pmid:26118667 + pubmed:24511233 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HBP:"CDK5R1 p25") + path(MESH:"Alzheimer Disease") association path(MESH:"Psychotic Disorders") - pmid:21910444 + pubmed:24511233 - path(MESH:"Alzheimer Disease") increases p(HGNC:MAPK1) + path(MESH:"Alzheimer Disease") increases path(MESH:Depression) - pmid:21910444 + pubmed:26813123 - path(MESH:"Alzheimer Disease") increases p(HGNC:PRKCB) + path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:Depression) - pmid:24401760 + pubmed:24511233 - path(MESH:"Alzheimer Disease") increases p(HGNC:ITPKB) + path(MESH:"Alzheimer Disease") increases path(MESH:Anxiety) - pmid:24401760 + pubmed:24511233 - path(MESH:"Alzheimer Disease") positiveCorrelation path(HBP:Astrogliosis) + path(MESH:"Alzheimer Disease") association bp(MESH:Aging) - pmid:24401760 + pubmed:17009926 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:APP, frag("672_711")) + path(MESH:"Alzheimer Disease") association p(FPLX:CHRN) - pmid:29540553 + pubmed:17009926 - path(MESH:"Alzheimer Disease") negativeCorrelation p(MGI:Sirt3) + path(MESH:"Alzheimer Disease") negativeCorrelation act(p(FPLX:CHRN)) - pmid:29559585 + pubmed:17009926 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:GAPDH, pmod(NO)) + path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:CHRN) - pmid:21427723 + pubmed:17009926 - path(MESH:"Alzheimer Disease") isA path(HBP:"4R tauopathy") + path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:CHRN) - pmid:19732809 + pubmed:25514383 - path(MESH:"Alzheimer Disease") negativeCorrelation p(MESH:Proteins, pmod(HBP:"O-GlcNAcylation")) + path(MESH:"Alzheimer Disease") decreases p(FPLX:CHRN) - pmid:19732809 + pubmed:11230871 - path(MESH:"Alzheimer Disease") positiveCorrelation g(HGNC:OGA, var("?")) + path(MESH:"Alzheimer Disease") association p(FPLX:CHRN) - pmid:27716675 + pubmed:11230871 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SUMO1) + path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:CHRN) - pmid:19765634 + pubmed:17009926 - path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs761059) + path(MESH:"Alzheimer Disease") association complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7)) - pmid:29062069 + pubmed:26813123 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MID1) + path(MESH:"Alzheimer Disease") increases deg(a(MESH:"Basal Nucleus of Meynert")) - pmid:25001178 + pubmed:26813123 - path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:DUSP6) + path(MESH:"Alzheimer Disease") negativeCorrelation a(MESH:"Basal Nucleus of Meynert") - pmid:25001178 + pubmed:26813123 - path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PPP1CA) + path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:Apathy) - pmid:29281045 + pubmed:26813123 - path(MESH:"Alzheimer Disease") decreases p(HGNC:LCMT1) + path(MESH:"Alzheimer Disease") negativeCorrelation a(CHEBI:rivastigmine) - pmid:29281045 + pubmed:26813123 - path(MESH:"Alzheimer Disease") increases p(HGNC:PPME1) + path(MESH:"Alzheimer Disease") negativeCorrelation complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) - pmid:24964035 + pubmed:24590577 - path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:SMAD) + path(MESH:"Alzheimer Disease") association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") - pmid:23157676 + pubmed:19721446 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HBP:"cis p-tau") + path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") - pmid:24561250 + pubmed:25514383 - path(MESH:"Alzheimer Disease") association complex(GO:"NLRP3 inflammasome complex") + path(MESH:"Alzheimer Disease") negativeCorrelation a(GO:synapse) - pmid:24561250 + pubmed:22908190 - path(MESH:"Alzheimer Disease") positiveCorrelation bp(GO:aging) + path(MESH:"Alzheimer Disease") negativeCorrelation act(a(GO:synapse)) - pmid:24561250 + pubmed:22908190 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:PYCARD) + path(MESH:"Alzheimer Disease") negativeCorrelation act(a(GO:synapse)) - pmid:24561250 + pubmed:25514383 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:NLRC4) + path(MESH:"Alzheimer Disease") negativeCorrelation a(MESH:"White Matter") - pmid:24561250 + pubmed:26195256 - path(MESH:"Alzheimer Disease") association complex(GO:"IPAF inflammasome complex") + path(MESH:"Alzheimer Disease") association a(MESH:"White Matter") - pmid:27314526 + pubmed:25514383 - path(MESH:"Alzheimer Disease") association complex(GO:"inflammasome complex") + path(MESH:"Alzheimer Disease") negativeCorrelation a(HP:"cholinergic neuron") - pmid:27314526 + pubmed:25514383 - path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:P2RX7) + path(MESH:"Alzheimer Disease") decreases complex(a(CHEBI:acetylcholine), p(FPLX:CHRN)) - pmid:25514383 + pubmed:25514383 - bp(GO:"neuron cellular homeostasis") association complex(a(CHEBI:"amyloid-beta"), p(FPLX:CHRN)) + path(MESH:"Alzheimer Disease") decreases complex(a(CHEBI:acetylcholine), p(FPLX:CHRM)) - pmid:30046111 + pubmed:25514383 - bp(GO:aging) decreases bp(GO:"cerebrospinal fluid circulation") + path(MESH:"Alzheimer Disease") decreases complex(a(CHEBI:nicotine), p(FPLX:CHRN)) - pmid:30046111 + pubmed:11230871 - bp(GO:aging) decreases act(a(HP:"interstitial fluid")) + path(MESH:"Alzheimer Disease") decreases complex(a(CHEBI:nicotine), p(FPLX:CHRN)) - pmid:30046111 + pubmed:25514383 - bp(GO:aging) increases a(CHEBI:"amyloid-beta") + path(MESH:"Alzheimer Disease") decreases complex(a(CHEBI:nicotine), p(FPLX:CHRM)) - pmid:29626319 + pubmed:25514383 - bp(GO:aging) positiveCorrelation a(CHEBI:"amyloid-beta") + path(MESH:"Alzheimer Disease") decreases p(FPLX:CHRM) - pmid:29421605 + pubmed:25514383 - bp(GO:aging) positiveCorrelation a(CHEBI:"amyloid-beta") + path(MESH:"Alzheimer Disease") positiveCorrelation complex(p(HGNC:CHRNA7), p(HGNC:FLNA)) - pmid:30046111 + pubmed:21718217 - bp(GO:aging) decreases act(a(MESH:"Lymphatic Vessels")) + path(MESH:"Alzheimer Disease") positiveCorrelation g(CONSO:CONSO00030) - pmid:30046111 + pubmed:21718217 - bp(GO:aging) negativeCorrelation act(a(MESH:"Lymphatic Vessels")) + path(MESH:"Alzheimer Disease") association g(CONSO:CONSO00030) - pmid:30046111 + pubmed:21718217 - bp(GO:aging) decreases tloc(a(CHEBI:macromolecule), fromLoc(GO:"extracellular space"), toLoc(MESH:"Intracellular Space")) + path(MESH:"Alzheimer Disease") positiveCorrelation r(HGNC:ARG1) - pmid:30046111 + pubmed:21718217 - bp(GO:aging) association bp(GO:"immune response") + path(MESH:"Alzheimer Disease") positiveCorrelation r(HGNC:CHI3L1) - pmid:30046111 + pubmed:18986241 - bp(GO:aging) association bp(GO:"inflammatory response") + path(MESH:"Alzheimer Disease") decreases path(MESH:Memory) - pmid:30046111 + pubmed:18986241 - bp(GO:aging) association bp(GO:"phospholipid metabolic process") + path(MESH:"Alzheimer Disease") decreases path(MESH:Cognition) - pmid:30046111 + pubmed:18986241 - bp(GO:aging) association bp(GO:"extracellular matrix organization") + path(MESH:"Alzheimer Disease") association path(MESH:"Behavioral Symptoms") - pmid:30046111 + pubmed:18986241 - bp(GO:aging) association bp(GO:"cell adhesion") + path(MESH:"Alzheimer Disease") association path(CONSO:aMCI) - pmid:30046111 + pubmed:18986241 - bp(GO:aging) association bp(GO:"endothelial tube morphogenesis") + path(MESH:"Alzheimer Disease") decreases path(MESH:"Cholinergic Neurons") - pmid:30046111 + pubmed:18986241 - bp(GO:aging) decreases p(MGI:Cdk5r1) + path(MESH:"Alzheimer Disease") association path(MESH:"Cholinergic Neurons") - pmid:30046111 + pubmed:18986241 - bp(GO:aging) decreases p(MGI:Adamts3) + path(MESH:"Alzheimer Disease") decreases path(MESH:"Cholinergic Neurons") - pmid:30046111 + pubmed:18986241 - bp(GO:aging) decreases p(MGI:Fgfr3) + path(MESH:"Alzheimer Disease") causesNoChange p(HGNC:SLC18A3) - pmid:29196815 + pubmed:18986241 - bp(GO:aging) increases path(MESH:"Alzheimer Disease") + path(MESH:"Alzheimer Disease") increases a(MESH:"pro-nerve growth factor, human") - pmid:24561250 + pubmed:18986241 - bp(GO:aging) positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:"Alzheimer Disease") decreases p(HGNC:NTRK1) - pmid:29196815 + pubmed:18986241 - bp(GO:aging) increases a(HBP:HBP00074) + path(MESH:"Alzheimer Disease") increases p(HGNC:NGF) - pmid:25514383 + pubmed:18986241 - bp(GO:aging) association path(MESH:Dementia) + path(MESH:"Alzheimer Disease") association p(HGNC:SORT1) - pmid:27522251 + pubmed:18986241 - bp(GO:aging) association p(MGI:Chrna7) + path(MESH:"Alzheimer Disease") decreases bp(GO:"nerve growth factor processing") - pmid:11230871 + pubmed:18986241 - bp(GO:aging) negativeCorrelation complex(a(CHEBI:epibatidine), p(FPLX:CHRN)) + path(MESH:"Alzheimer Disease") increases act(p(HGNC:MMP9)) - pmid:11230871 + pubmed:18986241 - bp(GO:aging) negativeCorrelation complex(a(CHEBI:epibatidine), p(FPLX:CHRN)) + path(MESH:"Alzheimer Disease") decreases g(HGNC:NTRK1) - pmid:11230871 + pubmed:18986241 - bp(GO:aging) causesNoChange r(HGNC:CHRNA3) + path(MESH:"Alzheimer Disease") decreases g(HGNC:NTRK2) - pmid:11230871 + pubmed:18986241 - bp(GO:aging) negativeCorrelation r(HBP:"alpha-4-containing nAChR") + path(MESH:"Alzheimer Disease") decreases g(HGNC:NTRK3) - pmid:11230871 + pubmed:18986241 - bp(GO:aging) negativeCorrelation r(HBP:"alpha-7-containing nAChR") + path(MESH:"Alzheimer Disease") increases g(HGNC:NGFR) - pmid:23454242 + pubmed:18986241 - bp(GO:aging) increases p(HGNC:PPP2R2C) + path(MESH:"Alzheimer Disease") causesNoChange r(HGNC:CHAT) - pmid:23454242 + pubmed:18986241 - bp(GO:aging) decreases p(HGNC:PPP2R2B) + path(MESH:"Alzheimer Disease") increases r(HGNC:CHRNA7) - pmid:28083634 + pubmed:18986241 - bp(GO:aging) increases p(MGI:Otub1) + path(MESH:"Alzheimer Disease") increases r(HGNC:CHRNA7) - pmid:27491084 + pubmed:11230871 - bp(GO:aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") + path(MESH:"Alzheimer Disease") positiveCorrelation r(HGNC:CHRNA7) - pmid:27491084 + pubmed:18986241 - bp(GO:aging) decreases p(FPLX:HSPA) + path(MESH:"Alzheimer Disease") causesNoChange r(HGNC:CHRM1) - pmid:27491084 + pubmed:18986241 - bp(GO:aging) increases p(FPLX:HSPB) + path(MESH:"Alzheimer Disease") decreases r(HGNC:SYP) - pmid:14556719 + pubmed:18986241 - bp(GO:aging) negativeCorrelation act(complex(GO:"proteasome complex")) + path(MESH:"Alzheimer Disease") decreases r(HGNCGENEFAMILY:Synaptotagmins) - pmid:22908190 + pubmed:18986241 - bp(GO:aging) negativeCorrelation act(complex(GO:"proteasome complex")) + path(MESH:"Alzheimer Disease") causesNoChange r(HGNC:SNAP29) - pmid:22908190 + pubmed:18986241 - bp(GO:aging) negativeCorrelation act(complex(GO:"proteasome complex")) + path(MESH:"Alzheimer Disease") causesNoChange r(HGNC:APP) - pmid:14556719 + pubmed:18986241 - bp(GO:aging) negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + path(MESH:"Alzheimer Disease") causesNoChange r(HGNC:NOTCH1) - pmid:14556719 + pubmed:18986241 - bp(GO:aging) increases p(HGNC:PRNP) + path(MESH:"Alzheimer Disease") increases r(HGNC:CTSD) - pmid:23746257 + pubmed:18986241 - bp(GO:aging) decreases bp(HBP:Proteostasis) + path(MESH:"Alzheimer Disease") decreases r(HGNC:PPP1CA) - pmid:23746257 + pubmed:18986241 - bp(GO:aging) decreases bp(HBP:Proteostasis) + path(MESH:"Alzheimer Disease") decreases r(HGNC:PPP1CC) - pmid:24563850 + pubmed:18986241 - bp(GO:aging) positiveCorrelation bp(HBP:"non-enzymatic protein modification") + path(MESH:"Alzheimer Disease") causesNoChange r(HGNC:MAPT) - pmid:24563850 + pubmed:18986241 - bp(GO:aging) association bp(GO:"protein oxidation") + path(MESH:"Alzheimer Disease") decreases p(CONSO:"3R tau") - pmid:30145931 + pubmed:27574109 - bp(GO:aging) increases p(HGNC:MAPT) + path(MESH:"Alzheimer Disease") positiveCorrelation p(CONSO:"3R tau") - pmid:30145931 + pubmed:26631930 - bp(GO:aging) decreases p(HGNC:MAPT) + path(MESH:"Alzheimer Disease") positiveCorrelation p(CONSO:"3R tau") - pmid:21882945 + pubmed:11230871 - bp(GO:aging) negativeCorrelation deg(p(HGNC:MAPT)) + path(MESH:"Alzheimer Disease") negativeCorrelation complex(CONSO:"alpha-4-containing nAChR") - pmid:29238289 + pubmed:11230871 - bp(GO:aging) increases p(HGNC:MAPT) + path(MESH:"Alzheimer Disease") causesNoChange complex(CONSO:"alpha-7-containing nAChR") - pmid:30116051 + pubmed:11230871 - bp(GO:aging) negativeCorrelation act(p(HGNC:SIRT1)) + path(MESH:"Alzheimer Disease") negativeCorrelation complex(CONSO:"alpha-7-containing nAChR") - pmid:30116051 + pubmed:11230871 - bp(GO:aging) decreases a(CHEBI:"NAD(+)") + path(MESH:"Alzheimer Disease") causesNoChange r(HGNC:CHRNA3) - pmid:29024336 + pubmed:11230871 - bp(GO:aging) increases path(MESH:"Proteostasis Deficiencies") + path(MESH:"Alzheimer Disease") causesNoChange r(HGNC:CHRNA4) - pmid:29024336 + pubmed:11230871 - bp(GO:aging) increases path(MESH:"Proteostasis Deficiencies") + path(MESH:"Alzheimer Disease") decreases complex(CONSO:"alpha-4 beta-2 nAChR") - pmid:21882945 + pubmed:19721446 - bp(GO:aging) positiveCorrelation p(HGNC:FKBP5) + path(MESH:"Alzheimer Disease") decreases a(MESH:Neurons) - pmid:29191965 + pubmed:19721446 - bp(GO:aging) decreases bp(GO:locomotion) + path(MESH:"Alzheimer Disease") decreases path(MESH:"Memory, Episodic") - pmid:28877763 + pubmed:26837465 - bp(GO:aging) increases p(MGI:Syk, pmod(Ph)) + path(MESH:"Alzheimer Disease") increases complex(p(HGNC:ESR1), p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) - pmid:28877763 + pubmed:28901280 - bp(GO:aging) increases p(MGI:Syk, pmod(Ph)) + path(MESH:"Alzheimer Disease") association p(MESH:"Receptors, Nicotinic") - pmid:28877763 + pubmed:23178521 - bp(GO:aging) increases a(HBP:"Tau aggregates") + path(MESH:"Alzheimer Disease") increases p(MGI:Il6) - pmid:26631930 + pubmed:23178521 - bp(GO:aging) positiveCorrelation a(HBP:"Tau aggregates") + path(MESH:"Alzheimer Disease") increases p(MGI:Tnf) - pmid:28877763 + pubmed:23178521 - bp(GO:aging) increases p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) + path(MESH:"Alzheimer Disease") increases p(MGI:Stat3, pmod(go:0006468 ! "protein phosphorylation")) - pmid:29626319 + pubmed:22020111 - bp(GO:aging) negativeCorrelation p(HGNC:IDE) + path(MESH:"Alzheimer Disease") positiveCorrelation a(CONSO:"protein aggregates") - pmid:25681682 + pubmed:22020111 - bp(GO:aging) negativeCorrelation p(HGNC:AGER) + path(MESH:"Alzheimer Disease") increases g(HGNC:ANP32A) - pmid:19118186 + pubmed:22020111 - bp(GO:aging) decreases bp(GO:memory) + path(MESH:"Alzheimer Disease") increases g(HGNC:BAX) - pmid:28877763 + pubmed:22020111 - bp(GO:aging) increases a(HBP:"dystrophic neurite") + path(MESH:"Alzheimer Disease") increases g(HGNC:BCHE) - pmid:29421605 + pubmed:22020111 - bp(GO:aging) positiveCorrelation p(RGD:Ptpn1) + path(MESH:"Alzheimer Disease") increases g(HGNC:BGN) - pmid:29421605 + pubmed:22020111 - bp(GO:aging) negativeCorrelation p(RGD:Irs1, pmod(Ph)) + path(MESH:"Alzheimer Disease") increases g(HGNC:BRCA1) - pmid:29421605 + pubmed:22020111 - bp(GO:aging) negativeCorrelation p(RGD:Akt1, pmod(Ph)) + path(MESH:"Alzheimer Disease") increases g(HGNC:CAPN1) - pmid:29421605 + pubmed:22020111 - bp(GO:aging) negativeCorrelation p(RGD:Gsk3b, pmod(Ph)) + path(MESH:"Alzheimer Disease") increases g(HGNC:CCNB1) - pmid:29421605 + pubmed:22020111 - bp(GO:aging) negativeCorrelation p(RGD:Mtor, pmod(Ph)) + path(MESH:"Alzheimer Disease") increases g(HGNC:CDK1) - pmid:29421605 + pubmed:22020111 - bp(GO:aging) negativeCorrelation p(RGD:Ntrk2, pmod(Ph)) + path(MESH:"Alzheimer Disease") increases g(HGNC:CDK2) - pmid:29421605 + pubmed:22020111 - bp(GO:aging) positiveCorrelation p(RGD:Mapt, pmod(Ph)) + path(MESH:"Alzheimer Disease") increases g(HGNC:CDKN2A) - pmid:24561250 + pubmed:22020111 - bp(GO:aging) increases act(complex(GO:"NLRP1 inflammasome complex")) + path(MESH:"Alzheimer Disease") increases g(HGNC:CXCR4) - pmid:24561250 + pubmed:22020111 - bp(GO:aging) increases p(HGNC:IL1B) + path(MESH:"Alzheimer Disease") increases g(HGNC:EIF4EBP1) - pmid:24561250 + pubmed:22020111 - bp(GO:aging) increases p(HGNC:IL18) + path(MESH:"Alzheimer Disease") increases g(HGNC:FOLH1) - pmid:30046111 + pubmed:22020111 - bp(GO:"cerebrospinal fluid circulation") decreases a(CHEBI:"amyloid-beta") + path(MESH:"Alzheimer Disease") increases g(HGNC:HOMER1) - pmid:30046111 + pubmed:22020111 - act(a(HP:"interstitial fluid")) decreases a(CHEBI:"amyloid-beta") + path(MESH:"Alzheimer Disease") increases g(HGNC:HRH1) - pmid:30046111 + pubmed:22020111 - a(MESH:"Lymphatic Vessels") regulates bp(MESH:Homeostasis) + path(MESH:"Alzheimer Disease") increases g(HGNC:IGF2) - pmid:30046111 + pubmed:22020111 - a(MESH:"Lymphatic Vessels") increases tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Cerebrospinal Fluid"), toLoc(MESH:"Lymph Nodes")) + path(MESH:"Alzheimer Disease") increases g(HGNC:IGFBP2) - pmid:30046111 + pubmed:22020111 - act(a(MESH:"Lymphatic Vessels")) association tloc(a(CHEBI:macromolecule), fromLoc(GO:"extracellular space"), toLoc(MESH:"Intracellular Space")) + path(MESH:"Alzheimer Disease") increases g(HGNC:LDLR) - pmid:30046111 + pubmed:22020111 - act(a(MESH:"Lymphatic Vessels")) increases tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Parenchymal Tissue"), toLoc(MESH:"Lymph Nodes")) + path(MESH:"Alzheimer Disease") increases g(HGNC:MAOA) - pmid:30046111 + pubmed:22020111 - act(a(MESH:"Lymphatic Vessels")) increases tloc(a(CHEBI:macromolecule), fromLoc(HP:"interstitial fluid"), toLoc(MESH:"Lymph Nodes")) + path(MESH:"Alzheimer Disease") increases g(HGNC:NEFH) - pmid:30046111 + pubmed:22020111 - act(a(MESH:"Lymphatic Vessels")) increases tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Cerebrospinal Fluid"), toLoc(MESH:"Parenchymal Tissue")) + path(MESH:"Alzheimer Disease") increases g(HGNC:NPDC1) - pmid:30046111 + pubmed:22020111 - act(a(MESH:"Lymphatic Vessels")) increases bp(MESH:"Cerebrovascular Circulation") + path(MESH:"Alzheimer Disease") increases g(HGNC:NRGN) - pmid:30046111 + pubmed:22020111 - act(a(MESH:"Lymphatic Vessels")) increases bp(MESH:"Cerebrovascular Circulation") + path(MESH:"Alzheimer Disease") increases g(HGNC:PREP) - pmid:30046111 + pubmed:22020111 - act(a(MESH:"Lymphatic Vessels")) association bp(MESH:"Cerebrovascular Circulation") + path(MESH:"Alzheimer Disease") increases g(HGNC:PROS1) - pmid:30046111 + pubmed:22020111 - act(a(MESH:"Lymphatic Vessels")) positiveCorrelation bp(MESH:"Cerebrovascular Circulation") + path(MESH:"Alzheimer Disease") increases g(HGNC:PTGS1) - pmid:30046111 + pubmed:22020111 - act(a(MESH:"Lymphatic Vessels")) increases bp(GO:"cerebrospinal fluid secretion") + path(MESH:"Alzheimer Disease") increases g(HGNC:SELENBP1) - pmid:30046111 + pubmed:22020111 - act(a(MESH:"Lymphatic Vessels")) increases tloc(a(CHEBI:"gadolinium atom"), fromLoc(GO:"extracellular space"), toLoc(MESH:"Cerebrospinal Fluid")) + path(MESH:"Alzheimer Disease") increases g(HGNC:TAGLN) - pmid:30046111 + pubmed:22020111 - act(a(MESH:"Lymphatic Vessels")) increases bp(GO:"fear response") + path(MESH:"Alzheimer Disease") increases g(HGNC:TGFB1) - pmid:30046111 + pubmed:22020111 - act(a(MESH:"Lymphatic Vessels")) increases path(MESH:"Spatial Learning") + path(MESH:"Alzheimer Disease") increases g(HGNC:TUBB3) - pmid:30046111 + pubmed:22020111 - act(a(MESH:"Lymphatic Vessels")) increases path(MESH:"Spatial Learning") + path(MESH:"Alzheimer Disease") increases g(HGNC:VKORC1) - pmid:30046111 + pubmed:22020111 - act(a(MESH:"Lymphatic Vessels")) increases bp(GO:memory) + path(MESH:"Alzheimer Disease") decreases g(HGNC:CANX) - pmid:30046111 + pubmed:22020111 - act(a(MESH:"Lymphatic Vessels")) increases bp(GO:memory) + path(MESH:"Alzheimer Disease") decreases g(HGNC:GCNT2) - pmid:30046111 + pubmed:22020111 - act(a(MESH:"Lymphatic Vessels")) association bp(GO:"gene expression") + path(MESH:"Alzheimer Disease") decreases g(HGNC:IDE) - pmid:30046111 + pubmed:22020111 - act(a(MESH:"Lymphatic Vessels")) association path(MESH:"Huntington Disease") + path(MESH:"Alzheimer Disease") decreases g(HGNC:MMP1) - pmid:30046111 + pubmed:22020111 - act(a(MESH:"Lymphatic Vessels")) association path(MESH:"Parkinson Disease") + path(MESH:"Alzheimer Disease") decreases g(HGNC:NFE2L2) - pmid:30046111 + pubmed:22020111 - act(a(MESH:"Lymphatic Vessels")) association path(MESH:"Alzheimer Disease") + path(MESH:"Alzheimer Disease") decreases g(HGNC:NR3C1) - pmid:30046111 + pubmed:22020111 - act(a(MESH:"Lymphatic Vessels")) association bp(GO:"excitatory chemical synaptic transmission") + path(MESH:"Alzheimer Disease") decreases g(HGNC:PPARA) - pmid:30046111 + pubmed:22020111 - act(a(MESH:"Lymphatic Vessels")) increases bp(GO:learning) + path(MESH:"Alzheimer Disease") decreases g(HGNC:SLC6A6) - pmid:30046111 + pubmed:22020111 - act(a(MESH:"Lymphatic Vessels")) increases bp(GO:cognition) + path(MESH:"Alzheimer Disease") decreases g(HGNC:SYVN1) - pmid:30046111 + pubmed:22020111 - act(a(MESH:"Lymphatic Vessels")) association bp(GO:"neuronal signal transduction") + path(MESH:"Alzheimer Disease") decreases g(HGNC:TSHZ1) - pmid:30046111 + pubmed:22020111 - act(a(MESH:"Lymphatic Vessels")) regulates a(CHEBI:metabolite) + path(MESH:"Alzheimer Disease") decreases g(HGNC:TXN) - pmid:30046111 + pubmed:22020111 - act(a(MESH:"Lymphatic Vessels")) regulates bp(MESH:Glycolysis) + path(MESH:"Alzheimer Disease") decreases g(HGNC:ACLY) - pmid:30046111 + pubmed:22020111 - act(a(MESH:"Lymphatic Vessels")) regulates bp(GO:"response to oxidative stress") + path(MESH:"Alzheimer Disease") decreases g(HGNC:ATAD2) - pmid:30046111 + pubmed:22020111 - act(a(MESH:"Lymphatic Vessels")) regulates bp(GO:"cellular respiration") + path(MESH:"Alzheimer Disease") decreases g(HGNC:BECN1) - pmid:30046111 + pubmed:22020111 - act(a(MESH:"Lymphatic Vessels")) negativeCorrelation bp(GO:aging) + path(MESH:"Alzheimer Disease") decreases g(HGNC:DHCR24) - pmid:30046111 + pubmed:22020111 - act(a(MESH:"Lymphatic Vessels")) increases act(p(MGI:Vegfc)) + path(MESH:"Alzheimer Disease") decreases g(HGNC:FGF2) - pmid:30046111 + pubmed:22020111 - act(a(MESH:"Lymphatic Vessels")) decreases a(CHEBI:"amyloid-beta") + path(MESH:"Alzheimer Disease") decreases g(HGNC:HTRA1) - pmid:30046111 + pubmed:22020111 - act(a(MESH:"Lymphatic Vessels")) negativeCorrelation a(CHEBI:"amyloid-beta") + path(MESH:"Alzheimer Disease") decreases g(HGNC:PRKCE) - pmid:30046111 + pubmed:22020111 - act(a(MESH:"Lymphatic Vessels")) decreases a(CHEBI:"amyloid-beta") + path(MESH:"Alzheimer Disease") decreases g(HGNC:PRKDC) - pmid:30046111 + pubmed:22020111 - act(a(MESH:"Lymphatic Vessels")) decreases a(CHEBI:"amyloid-beta") + path(MESH:"Alzheimer Disease") decreases g(HGNC:SCD) - pmid:30046111 + pubmed:22020111 - a(MESH:"Lymphatic Vessels") decreases a(CHEBI:"amyloid-beta") + path(MESH:"Alzheimer Disease") decreases g(HGNC:TUBB) - pmid:30046111 + pubmed:22020111 - act(a(MESH:"Lymphatic Vessels")) decreases bp(GO:"macrophage migration") + path(MESH:"Alzheimer Disease") decreases g(HGNC:UNG) - pmid:30046111 + pubmed:22020111 - act(a(MESH:"Lymphatic Vessels")) decreases a(MESH:Macrophages) + path(MESH:"Alzheimer Disease") increases g(HGNC:ATP1A1) - pmid:30046111 + pubmed:22020111 - act(a(MESH:"Lymphatic Vessels")) negativeCorrelation path(MESH:Inflammation) + path(MESH:"Alzheimer Disease") increases g(HGNC:CTSD) - pmid:30046111 + pubmed:22020111 - act(a(MESH:"Lymphatic Vessels")) decreases a(HBP:HBP00018) + path(MESH:"Alzheimer Disease") increases g(HGNC:GLRX) - pmid:30046111 + pubmed:22020111 - tloc(a(CHEBI:macromolecule), fromLoc(GO:"extracellular space"), toLoc(MESH:"Intracellular Space")) association act(a(MESH:"Lymphatic Vessels")) + path(MESH:"Alzheimer Disease") positiveCorrelation g(HGNC:GLRX) - pmid:30046111 + pubmed:22020111 - a(CHEBI:verteporfin) decreases a(MESH:"Lymphatic Vessels") + path(MESH:"Alzheimer Disease") increases g(HGNC:HMOX1) - pmid:30046111 + pubmed:22020111 - a(CHEBI:verteporfin) decreases act(a(MESH:"Lymphatic Vessels")) + path(MESH:"Alzheimer Disease") positiveCorrelation g(HGNC:HMOX1) - pmid:30046111 + pubmed:22020111 - a(CHEBI:verteporfin) decreases bp(MESH:"Cerebrovascular Circulation") + path(MESH:"Alzheimer Disease") increases g(HGNC:IL6R) - pmid:30046111 + pubmed:22020111 - a(CHEBI:verteporfin) decreases tloc(a(CHEBI:"gadolinium atom"), fromLoc(GO:"extracellular space"), toLoc(MESH:"Cerebrospinal Fluid")) + path(MESH:"Alzheimer Disease") increases g(HGNC:NPTX1) - pmid:30046111 + pubmed:22020111 - bp(MESH:"Cerebrovascular Circulation") association act(a(MESH:"Lymphatic Vessels")) + path(MESH:"Alzheimer Disease") increases g(HGNC:NQO1) - pmid:30046111 + pubmed:22020111 - bp(MESH:"Cerebrovascular Circulation") increases act(a(MESH:"Lymphatic Vessels")) + path(MESH:"Alzheimer Disease") positiveCorrelation g(HGNC:NQO1) - pmid:30046111 + pubmed:22020111 - bp(MESH:"Cerebrovascular Circulation") positiveCorrelation act(a(MESH:"Lymphatic Vessels")) + path(MESH:"Alzheimer Disease") increases g(HGNC:PHF1) - pmid:30046111 + pubmed:22020111 - bp(MESH:"Cerebrovascular Circulation") increases tloc(a(CHEBI:macromolecule), fromLoc(GO:"extracellular space"), toLoc(MESH:"Intracellular Space")) + path(MESH:"Alzheimer Disease") increases g(HGNC:PRKCD) - pmid:30126037 + pubmed:22020111 - bp(MESH:"Cerebrovascular Circulation") association p(MGI:Mapt, var("p.Pro301Leu")) + path(MESH:"Alzheimer Disease") increases g(HGNC:PTGS2) - pmid:30126037 + pubmed:22020111 - bp(MESH:"Cerebrovascular Circulation") association path(MESH:"Alzheimer Disease") + path(MESH:"Alzheimer Disease") increases g(HGNC:RANBP9) - pmid:30126037 + pubmed:22020111 - bp(MESH:"Cerebrovascular Circulation") association path(MESH:"Cognitive Dysfunction") + path(MESH:"Alzheimer Disease") increases g(HGNC:SOD1) - pmid:30046111 + pubmed:22020111 - p(MGI:Aqp4) regulates tloc(a(CHEBI:macromolecule), fromLoc(GO:"extracellular space"), toLoc(MESH:"Intracellular Space")) + path(MESH:"Alzheimer Disease") positiveCorrelation g(HGNC:SOD1) - pmid:30046111 + pubmed:30688256 - p(MGI:Aqp4) regulates tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Intracellular Space"), toLoc(GO:"extracellular space")) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:PSEN1, var("?")) - pmid:30046111 + pubmed:29758300 - p(MGI:Aqp4) decreases a(CHEBI:"amyloid-beta") + path(MESH:"Alzheimer Disease") association p(HGNC:PSEN1, var("?")) - pmid:30046111 + pubmed:23454242 - p(MGI:Aqp4) increases bp(GO:cognition) + path(MESH:"Alzheimer Disease") increases p(HGNC:SET) - pmid:26195256 + pubmed:24653673 - p(MGI:Aqp4) increases act(a(HBP:"Glymphatic System")) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SET) - pmid:19126755 + pubmed:22299660 - bp(GO:cognition) positiveCorrelation p(HBP:"alpha-4 beta-2 nAChR") + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SET) - pmid:19126755 + pubmed:23454242 - bp(GO:cognition) positiveCorrelation p(HGNC:CHRNA7) + path(MESH:"Alzheimer Disease") decreases act(p(FPLX:PPP2)) - pmid:19126755 + pubmed:22299660 - bp(GO:cognition) association act(p(HGNC:CHRNA7)) + path(MESH:"Alzheimer Disease") negativeCorrelation act(p(FPLX:PPP2)) - pmid:19721446 + pubmed:22299660 - bp(GO:cognition) positiveCorrelation p(HGNC:CHRNA7) + path(MESH:"Alzheimer Disease") negativeCorrelation act(p(FPLX:PPP2)) - pmid:19126755 + pubmed:24653673 - bp(GO:cognition) negativeCorrelation path(MESH:"Alzheimer Disease") + path(MESH:"Alzheimer Disease") association p(HGNC:GSK3B) - pmid:24511233 + pubmed:24653673 - bp(GO:cognition) association path(MESH:"Alzheimer Disease") + path(MESH:"Alzheimer Disease") association a(MESH:"Receptors, N-Methyl-D-Aspartate") - pmid:11230871 + pubmed:24653673 - bp(GO:cognition) negativeCorrelation path(MESH:"Alzheimer Disease") + path(MESH:"Alzheimer Disease") association p(HGNC:GRM5) - pmid:24511233 + pubmed:24653673 - bp(GO:cognition) association path(MESH:Schizophrenia) + path(MESH:"Alzheimer Disease") negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) - pmid:19721446 + pubmed:24653673 - bp(GO:cognition) association path(MESH:Schizophrenia) + path(MESH:"Alzheimer Disease") positiveCorrelation complex(GO:"protein phosphatase type 2A complex") - pmid:24511233 + pubmed:24653673 - bp(GO:cognition) association a(MESH:Hippocampus) + path(MESH:"Alzheimer Disease") negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) - pmid:24511233 + pubmed:24653673 - bp(GO:cognition) association a(MESH:"Cerebral Cortex") + path(MESH:"Alzheimer Disease") negativeCorrelation g(HGNC:PPP2CA) - pmid:24511233 + pubmed:24653673 - bp(GO:cognition) association bp(GO:"synaptic transmission, cholinergic") + path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:PPP2CA) - pmid:26813123 + pubmed:22299660 - bp(GO:cognition) association bp(GO:"synaptic transmission, cholinergic") + path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:PPP2CA) - pmid:21482353 + pubmed:22299660 - bp(GO:cognition) association bp(GO:"synaptic transmission, cholinergic") + path(MESH:"Alzheimer Disease") causesNoChange r(HGNC:PPP2CA) - pmid:24511233 + pubmed:24653673 - bp(GO:cognition) association p(HGNC:CHRM1) + path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PPP2CA) - pmid:24511233 + pubmed:26631930 - bp(GO:cognition) association p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits") + path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:PPP2CA)) - pmid:24511233 + pubmed:24653673 - bp(GO:cognition) association a(MESH:"Prefrontal Cortex") + path(MESH:"Alzheimer Disease") negativeCorrelation g(HGNC:PPP2CB) - pmid:26813123 + pubmed:24653673 - bp(GO:cognition) association bp(GO:"synaptic transmission, glutamatergic") + path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:PPP2CB) - pmid:26813123 + pubmed:22299660 - bp(GO:cognition) association a(CHEBI:acetylcholine) + path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:PPP2CB) - pmid:11230871 + pubmed:24653673 - bp(GO:cognition) negativeCorrelation a(CHEBI:acetylcholine) + path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PPP2CB) - pmid:25514383 + pubmed:24653673 - bp(GO:cognition) association a(HP:"cholinergic neuron") + path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:PPP2R2C) - pmid:28445721 + pubmed:24653673 - bp(GO:cognition) association p(FPLX:CHRN) + path(MESH:"Alzheimer Disease") negativeCorrelation r(HGNC:PPP2R5E) - pmid:28445721 + pubmed:24653673 - bp(GO:cognition) association p(FPLX:CHRN) + path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PPP2R2A) - pmid:28445721 + pubmed:22299660 - bp(GO:cognition) association p(FPLX:CHRN) + path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PPP2R2A) - pmid:11230871 + pubmed:24653673 - bp(GO:cognition) association p(FPLX:CHRN) + path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) - pmid:21482353 + pubmed:24653673 - bp(GO:cognition) positiveCorrelation a(HBP:"alpha-4 beta-2 nAChR") + path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) - pmid:21482353 + pubmed:24653673 - bp(GO:cognition) positiveCorrelation p(HGNC:CHRNA5, var("?")) + path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) - pmid:21482353 + pubmed:29281045 - bp(GO:cognition) positiveCorrelation p(HGNC:CHRNA3, var("?")) + path(MESH:"Alzheimer Disease") decreases p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) - pmid:21482353 + pubmed:24653673 - bp(GO:cognition) positiveCorrelation p(HGNC:CHRNB4, var("?")) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:ANP32A) - pmid:11230871 + pubmed:22299660 - bp(GO:cognition) association complex(a(CHEBI:nicotine), p(FPLX:CHRN)) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:ANP32A) - pmid:11230871 + pubmed:24653673 - bp(GO:cognition) association a(CHEBI:neurotransmitter) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SET, frag("?")) - pmid:22908190 + pubmed:24653673 - bp(GO:cognition) positiveCorrelation act(a(GO:synapse)) + path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PTPA) - pmid:24027553 + pubmed:24653673 - bp(GO:cognition) negativeCorrelation p(HBP:"Tau C3") + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) - pmid:21882945 + pubmed:17403556 - bp(GO:cognition) negativeCorrelation path(MESH:Tauopathies) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) - pmid:21882945 + pubmed:17403556 - bp(GO:cognition) positiveCorrelation a(PUBCHEM:134222899) + path(MESH:"Alzheimer Disease") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) - pmid:21882945 + pubmed:22253473 - bp(GO:cognition) positiveCorrelation a(CHEBI:"NMDA receptor antagonist") + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) - pmid:30985105 + pubmed:24653673 - bp(GO:cognition) association a(CHEBI:"amyloid-beta") + path(MESH:"Alzheimer Disease") negativeCorrelation complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) - pmid:24808823 + pubmed:24653673 - path(MESH:"Spatial Learning") negativeCorrelation p(MGI:Ttbk1) + path(MESH:"Alzheimer Disease") negativeCorrelation complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) - pmid:24808823 + pubmed:24653673 - path(MESH:"Spatial Learning") negativeCorrelation p(MGI:Cdk5) + path(MESH:"Alzheimer Disease") negativeCorrelation complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) - pmid:24808823 + pubmed:24653673 - path(MESH:"Spatial Learning") positiveCorrelation surf(p(MGI:Grin2b)) + path(MESH:"Alzheimer Disease") negativeCorrelation complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) - pmid:19293145 + pubmed:24653673 - bp(GO:memory) association composite(p(HGNC:MAPK1), p(HGNC:MAPK3)) + path(MESH:"Alzheimer Disease") negativeCorrelation complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) - pmid:24511233 + pubmed:24653673 - bp(GO:memory) association a(MESH:Hippocampus) + path(MESH:"Alzheimer Disease") negativeCorrelation complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) - pmid:24511233 + pubmed:12428809 - bp(GO:memory) association a(MESH:Hippocampus) + path(MESH:"Alzheimer Disease") association a(CONSO:"straight filaments") - pmid:19721446 + pubmed:12428809 - bp(GO:memory) association a(MESH:Hippocampus) + path(MESH:"Alzheimer Disease") positiveCorrelation p(CONSO:"4R tau") - pmid:24511233 + pubmed:27574109 - bp(GO:memory) association a(MESH:"Cerebral Cortex") + path(MESH:"Alzheimer Disease") positiveCorrelation p(CONSO:"4R tau") - pmid:24511233 + pubmed:26631930 - bp(GO:memory) association a(MESH:"Cerebral Cortex") + path(MESH:"Alzheimer Disease") positiveCorrelation p(CONSO:"4R tau") - pmid:24511233 + pubmed:12428809 - bp(GO:memory) association bp(GO:"long-term synaptic potentiation") + path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"axonal transport") - pmid:24511233 + pubmed:22908190 - bp(GO:memory) association a(MESH:"Prefrontal Cortex") + path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"axonal transport") - pmid:17009926 + pubmed:12428809 - bp(GO:memory) association p(FPLX:CHRN) + path(MESH:"Alzheimer Disease") association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396), pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) - pmid:11230871 + pubmed:21882945 - bp(GO:memory) association p(FPLX:CHRN) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396), pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) - pmid:26813123 + pubmed:22299660 - bp(GO:memory) association bp(GO:"synaptic transmission, cholinergic") + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 198)) - pmid:21482353 + pubmed:23088643 - bp(GO:memory) association bp(GO:"synaptic transmission, cholinergic") + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 198)) - pmid:26813123 + pubmed:22299660 - bp(GO:memory) positiveCorrelation a(CHEBI:acetylcholine) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) - pmid:26813123 + pubmed:26458742 - bp(GO:memory) association a(CHEBI:acetylcholine) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) - pmid:26813123 + pubmed:23088643 - bp(GO:memory) positiveCorrelation a(MESH:"Cholinergic Neurons") + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) - pmid:26813123 + pubmed:22299660 - bp(GO:memory) negativeCorrelation bp(HBP:Neurodegeneration) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) - pmid:26813123 + pubmed:29191965 - bp(GO:memory) association bp(MESH:"Synaptic Transmission") + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) - pmid:26813123 + pubmed:23088643 - bp(GO:memory) association p(HGNC:SYP) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) - pmid:24590577 + pubmed:22299660 - bp(GO:memory) association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) - pmid:24590577 + pubmed:22419736 - bp(GO:memory) association p(HGNC:CHRM1) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) - pmid:19721446 + pubmed:28420982 - bp(GO:memory) association p(HGNC:CHRNA7) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) - pmid:19721446 + pubmed:26458742 - bp(GO:memory) association a(MESH:"Entorhinal Cortex") + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) - pmid:30106381 + pubmed:22299660 - bp(GO:memory) association p(HGNC:ADNP) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) - pmid:30106381 + pubmed:22419736 - bp(GO:memory) association a(PUBCHEM:9832404) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) - pmid:30012004 + pubmed:26458742 - bp(GO:memory) negativeCorrelation path(MESH:"Huntington Disease") + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) - pmid:22908190 + pubmed:22299660 - bp(GO:memory) association bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) - pmid:19118186 + pubmed:29191965 - bp(GO:memory) negativeCorrelation p(MGI:Mapt) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) - pmid:28775333 + pubmed:26751493 - bp(GO:memory) positiveCorrelation a(CHEBI:"(-)-epigallocatechin 3-gallate") + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) - pmid:28775333 + pubmed:27373205 - bp(GO:memory) negativeCorrelation p(MGI:Dyrk1a) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) - pmid:24355211 + pubmed:23088643 - bp(GO:memory) negativeCorrelation p(HGNC:GSK3B) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) - pmid:27041503 + pubmed:22299660 - bp(GO:memory) association p(HGNC:WWC1) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) - pmid:28771976 + pubmed:29758300 - bp(GO:memory) association a(HBP:RGFP966) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) - pmid:21843595 + pubmed:26751493 - bp(GO:memory) negativeCorrelation p(MGI:Sumo3) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) - pmid:30046111 + pubmed:22299660 - bp(GO:"gene expression") association act(a(MESH:"Lymphatic Vessels")) + path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:PPP2C) - pmid:30046111 + pubmed:22299660 - path(MESH:"Huntington Disease") association act(a(MESH:"Lymphatic Vessels")) + path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:PPP2C, pmod(go:0006479 ! "protein methylation", Leu, 309)) - pmid:30663117 + pubmed:22299660 - path(MESH:"Huntington Disease") association path(MESH:Chorea) + path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:ICMT) - pmid:29687724 + pubmed:22299660 - path(MESH:"Huntington Disease") association path(MESH:Chorea) + path(MESH:"Alzheimer Disease") positiveCorrelation p(FPLX:PPP2C, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) - pmid:30663117 + pubmed:21722302 - path(MESH:"Huntington Disease") association path(MESH:Dementia) + path(MESH:"Alzheimer Disease") association path(CONSO:Neurodegeneration) - pmid:30012004 + pubmed:21722302 - path(MESH:"Huntington Disease") positiveCorrelation path(MESH:Dementia) + path(MESH:"Alzheimer Disease") association bp(CONSO:"protein aggregation") - pmid:30663117 + pubmed:21722302 - path(MESH:"Huntington Disease") association path(MESH:"Deglutition Disorders") + path(MESH:"Alzheimer Disease") association path(HP:"Senile plaques") - pmid:30663117 + pubmed:21722302 - path(MESH:"Huntington Disease") association path(MESH:Aphasia) + path(MESH:"Alzheimer Disease") association path(MESH:Neurites) - pmid:30663117 + pubmed:21722302 - path(MESH:"Huntington Disease") association path(MESH:Seizures) + path(MESH:"Alzheimer Disease") association p(PFAM:Presenilin, var("?")) - pmid:30663117 + pubmed:21722302 - path(MESH:"Huntington Disease") association g(HGNC:MIR196A1) + path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:HSPA5) - pmid:30663117 + pubmed:21722302 - path(MESH:"Huntington Disease") increases g(HGNC:MIR196A1) + path(MESH:"Alzheimer Disease") association p(HGNC:XBP1) - pmid:30663117 + pubmed:21722302 - path(MESH:"Huntington Disease") association g(HGNC:MIR206) + path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:XBP1) - pmid:30663117 + pubmed:21722302 - path(MESH:"Huntington Disease") association g(HGNC:MIR301B) + path(MESH:"Alzheimer Disease") decreases bp(MESH:"Unfolded Protein Response") - pmid:30663117 + pubmed:21722302 - path(MESH:"Huntington Disease") association g(HGNC:MIR92B) + path(MESH:"Alzheimer Disease") association a(GO:autophagosome) - pmid:30663117 + pubmed:29758300 - path(MESH:"Huntington Disease") association g(HGNC:MIR378B) + path(MESH:"Alzheimer Disease") increases a(GO:autophagosome) - pmid:30663117 + pubmed:22908190 - path(MESH:"Huntington Disease") association g(HGNC:MIR208B) + path(MESH:"Alzheimer Disease") positiveCorrelation a(GO:autophagosome) - pmid:30663117 + pubmed:18930136 - path(MESH:"Huntington Disease") association g(HGNC:MIR449A) + path(MESH:"Alzheimer Disease") positiveCorrelation a(GO:autophagosome) - pmid:30663117 + pubmed:18930136 - path(MESH:"Huntington Disease") decreases g(NCBIGENE:406915) + path(MESH:"Alzheimer Disease") positiveCorrelation a(GO:autophagosome) - pmid:30663117 + pubmed:21722302 - path(MESH:"Huntington Disease") increases g(MIRBASE:"hsa-mir-10b") + path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:autophagy) - pmid:30663117 + pubmed:29758300 - path(MESH:"Huntington Disease") increases g(HGNC:MIR196B) + path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:autophagy) - pmid:30663117 + pubmed:22908190 - path(MESH:"Huntington Disease") increases g(HGNC:MIR615) + path(MESH:"Alzheimer Disease") association bp(GO:autophagy) - pmid:30663117 + pubmed:22908190 - path(MESH:"Huntington Disease") increases g(HGNC:MIR1247) + path(MESH:"Alzheimer Disease") association bp(GO:autophagy) - pmid:30663117 + pubmed:25437566 - path(MESH:"Huntington Disease") decreases g(MGI:Mir22) + path(MESH:"Alzheimer Disease") decreases p(HGNC:HSP90AB1) - pmid:30663117 + pubmed:25437566 - path(MESH:"Huntington Disease") decreases g(MGI:Mir29c) + path(MESH:"Alzheimer Disease") decreases p(HGNC:HSPA8) - pmid:30663117 + pubmed:25437566 - path(MESH:"Huntington Disease") decreases g(MGI:"Mir128-1") + path(MESH:"Alzheimer Disease") decreases p(HGNC:HSPA14) - pmid:30663117 + pubmed:25437566 - path(MESH:"Huntington Disease") decreases g(MGI:Mir132) + path(MESH:"Alzheimer Disease") decreases p(HGNC:TCP1) - pmid:30663117 + pubmed:27491084 - path(MESH:"Huntington Disease") decreases g(MGI:"Mir138-1") + path(MESH:"Alzheimer Disease") decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") - pmid:30663117 + pubmed:27491084 - path(MESH:"Huntington Disease") decreases g(MGI:"Mir218-1") + path(MESH:"Alzheimer Disease") increases p(HGNC:HSPB1) - pmid:30663117 + pubmed:27491084 - path(MESH:"Huntington Disease") decreases g(MGI:Mir222) + path(MESH:"Alzheimer Disease") increases p(HGNC:CRYAB) - pmid:30663117 + pubmed:27491084 - path(MESH:"Huntington Disease") decreases g(NCBIGENE:723931) + path(MESH:"Alzheimer Disease") increases p(FPLX:HSPB) - pmid:30663117 + pubmed:29758300 - path(MESH:"Huntington Disease") decreases g(NCBIGENE:732489) + path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:macroautophagy) - pmid:26813123 + pubmed:29758300 - path(MESH:"Huntington Disease") negativeCorrelation act(p(HGNC:CHAT)) + path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:macroautophagy) - pmid:30012004 + pubmed:29758300 - path(MESH:"Huntington Disease") positiveCorrelation bp(GO:"neuron death") + path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:macroautophagy) - pmid:30012004 + pubmed:29758300 - path(MESH:"Huntington Disease") positiveCorrelation bp(GO:"neuron death") + path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:macroautophagy) - pmid:30012004 + pubmed:25784053 - path(MESH:"Huntington Disease") positiveCorrelation path(MESH:Atrophy) + path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:macroautophagy) - pmid:30012004 + pubmed:29758300 - path(MESH:"Huntington Disease") positiveCorrelation path(HBP:Excitotoxicity) + path(MESH:"Alzheimer Disease") increases complex(a(CONSO:"dystrophic neurite"), a(GO:autophagosome)) - pmid:30012004 + pubmed:29758300 - path(MESH:"Huntington Disease") positiveCorrelation path(MESH:"Oxidative Stress") + path(MESH:"Alzheimer Disease") positiveCorrelation a(GO:autolysosome) - pmid:30012004 + pubmed:23528736 - path(MESH:"Huntington Disease") negativeCorrelation bp(MESH:"Energy Metabolism") + path(MESH:"Alzheimer Disease") increases a(GO:autolysosome) - pmid:30012004 + pubmed:23528736 - path(MESH:"Huntington Disease") positiveCorrelation path(HBP:"mitochondrial dysfunction") + path(MESH:"Alzheimer Disease") increases a(GO:autolysosome) - pmid:30012004 + pubmed:29758300 - path(MESH:"Huntington Disease") positiveCorrelation path(MESH:Inflammation) + path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"lysosomal protein catabolic process") - pmid:30012004 + pubmed:22908190 - path(MESH:"Huntington Disease") positiveCorrelation bp(GO:"apoptotic process") + path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"lysosomal protein catabolic process") - pmid:30012004 + pubmed:23528736 - path(MESH:"Huntington Disease") positiveCorrelation bp(GO:autophagy) + path(MESH:"Alzheimer Disease") decreases bp(GO:"lysosomal protein catabolic process") - pmid:30012004 + pubmed:29758300 - path(MESH:"Huntington Disease") negativeCorrelation bp(GO:"dopamine metabolic process") + path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:BECN1) - pmid:30012004 + pubmed:29758300 - path(MESH:"Huntington Disease") negativeCorrelation bp(GO:"D-glutamate metabolic process") + path(MESH:"Alzheimer Disease") decreases p(HGNC:BECN1) - pmid:30012004 + pubmed:29758300 - path(MESH:"Huntington Disease") negativeCorrelation bp(GO:"cannabinoid biosynthetic process") + path(MESH:"Alzheimer Disease") increases a(GO:lysosome) - pmid:30012004 + pubmed:22908190 - path(MESH:"Huntington Disease") negativeCorrelation bp(GO:"adenosine catabolic process") + path(MESH:"Alzheimer Disease") positiveCorrelation a(GO:lysosome) - pmid:30012004 + pubmed:22908190 - path(MESH:"Huntington Disease") negativeCorrelation a(MESH:"Gray Matter") + path(MESH:"Alzheimer Disease") negativeCorrelation act(a(GO:lysosome)) - pmid:30012004 + pubmed:29758300 - path(MESH:"Huntington Disease") negativeCorrelation a(MESH:"White Matter") + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SNCA) - pmid:30012004 + pubmed:29758300 - path(MESH:"Huntington Disease") negativeCorrelation bp(GO:"motor behavior") + path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:endocytosis) - pmid:29687724 + pubmed:22908190 - path(MESH:"Huntington Disease") decreases bp(GO:"motor behavior") + path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:endocytosis) - pmid:30012004 + pubmed:22908190 - path(MESH:"Huntington Disease") negativeCorrelation bp(GO:memory) + path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:endocytosis) - pmid:30012004 + pubmed:29758300 - path(MESH:"Huntington Disease") negativeCorrelation bp(GO:"psychomotor behavior") + path(MESH:"Alzheimer Disease") association a(CONSO:"alpha-synuclein aggregates") - pmid:30012004 + pubmed:29758300 - path(MESH:"Huntington Disease") negativeCorrelation bp(GO:"sensory perception") + path(MESH:"Alzheimer Disease") positiveCorrelation a(CONSO:"alpha-synuclein aggregates") - pmid:30012004 + pubmed:29758300 - path(MESH:"Huntington Disease") negativeCorrelation bp(GO:"visual learning") + path(MESH:"Alzheimer Disease") association a(CHEBI:sphingolipid) - pmid:29687724 + pubmed:29758300 - path(MESH:"Huntington Disease") association path(MESH:"Neurodegenerative Diseases") + path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:ceramide) - pmid:29687724 + pubmed:29758300 - path(MESH:"Huntington Disease") association path(MESH:Cognition) + path(MESH:"Alzheimer Disease") association p(HGNC:TFEB) - pmid:29687724 + pubmed:29758300 - path(MESH:"Huntington Disease") decreases bp(GO:behavior) + path(MESH:"Alzheimer Disease") association p(HGNC:PICALM, var("?")) - pmid:29687724 + pubmed:26195256 - path(MESH:"Huntington Disease") association path(MESH:Dystonia) + path(MESH:"Alzheimer Disease") association p(HGNC:PICALM, var("?")) - pmid:29687724 + pubmed:29758300 - path(MESH:"Huntington Disease") association path(MESH:"Neural Pathways") + path(MESH:"Alzheimer Disease") association p(HGNC:VPS35, var("?")) - pmid:29687724 + pubmed:29758300 - path(MESH:"Huntington Disease") association a(CHEBI:dopamine) + path(MESH:"Alzheimer Disease") association p(HGNC:SORL1) - pmid:29687724 + pubmed:29758300 - path(MESH:"Huntington Disease") association path(MESH:Depression) + path(MESH:"Alzheimer Disease") increases bp(GO:mitophagy) - pmid:29687724 + pubmed:14556719 - path(MESH:"Huntington Disease") association path(MESH:"Motor Disorders") + path(MESH:"Alzheimer Disease") decreases bp(GO:"short-term memory") - pmid:29687724 + pubmed:14556719 - path(MESH:"Huntington Disease") association path(MESH:"Schizophrenia, Disorganized") + path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:UBA1)) - pmid:29687724 + pubmed:14556719 - path(MESH:"Huntington Disease") association path(MESH:"Cognitive Dysfunction") + path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:UBA2)) - pmid:29687724 + pubmed:14556719 - path(MESH:"Huntington Disease") association a(CHEBI:amantadine) + path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:29687724 + pubmed:23528736 - path(MESH:"Huntington Disease") association a(PUBCHEM:9795739) + path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:25437566 + pubmed:29626319 - path(MESH:"Huntington Disease") decreases p(HGNC:HSP90AB1) + path(MESH:"Alzheimer Disease") decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:25437566 + pubmed:22908190 - path(MESH:"Huntington Disease") decreases p(HGNC:HSPA8) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) - pmid:25437566 + pubmed:22908190 - path(MESH:"Huntington Disease") decreases p(HGNC:HSPA14) + path(MESH:"Alzheimer Disease") positiveCorrelation p(CONSO:"UBB+1") - pmid:25437566 + pubmed:23528736 - path(MESH:"Huntington Disease") decreases p(HGNC:TCP1) + path(MESH:"Alzheimer Disease") positiveCorrelation p(CONSO:"UBB+1") - pmid:14556719 + pubmed:22908190 - path(MESH:"Huntington Disease") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) + path(MESH:"Alzheimer Disease") association p(HGNC:UCHL1) - pmid:14556719 + pubmed:22908190 - path(MESH:"Huntington Disease") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) + path(MESH:"Alzheimer Disease") association p(HGNC:UBQLN1) - pmid:25784053 + pubmed:22908190 - path(MESH:"Huntington Disease") positiveCorrelation p(FPLX:HSPA) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:UBQLN1, var("?")) - pmid:25784053 + pubmed:22908190 - path(MESH:"Huntington Disease") negativeCorrelation p(HGNC:ATF6) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:RAB7A) - pmid:18930136 + pubmed:22908190 - path(MESH:"Huntington Disease") increases p(HGNC:CTSD) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:RAB5A) - pmid:18930136 + pubmed:22908190 - path(MESH:"Huntington Disease") positiveCorrelation a(GO:autolysosome) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:RAB4A) - pmid:29024336 + pubmed:22908190 - path(MESH:"Huntington Disease") increases path(MESH:"Proteostasis Deficiencies") + path(MESH:"Alzheimer Disease") positiveCorrelation a(CONSO:"dystrophic neurite") - pmid:29311797 + pubmed:22908190 - path(MESH:"Huntington Disease") association p(HGNC:STUB1) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:APP, var("?")) - pmid:30046111 + pubmed:22908190 - path(MESH:"Parkinson Disease") association act(a(MESH:"Lymphatic Vessels")) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:APP, var("?")) - pmid:30663117 + pubmed:22908190 - path(MESH:"Parkinson Disease") association a(HBP:"alpha-synuclein aggregates") + path(MESH:"Alzheimer Disease") association g(CONSO:"APOE e4") - pmid:30663117 + pubmed:26195256 - path(MESH:"Parkinson Disease") association g(HGNC:MIR132) + path(MESH:"Alzheimer Disease") positiveCorrelation g(CONSO:"APOE e4") - pmid:30663117 + pubmed:25784053 - path(MESH:"Parkinson Disease") association g(NCBIGENE:406950) + path(MESH:"Alzheimer Disease") negativeCorrelation act(p(FPLX:Proteasome)) - pmid:30663117 + pubmed:8282104 - path(MESH:"Parkinson Disease") association p(HGNC:LRRK2) + path(MESH:"Alzheimer Disease") positiveCorrelation p(FPLX:ERK) - pmid:24113872 + pubmed:8282104 - path(MESH:"Parkinson Disease") positiveCorrelation p(HGNC:LRRK2) + path(MESH:"Alzheimer Disease") positiveCorrelation p(FPLX:GSK3) - pmid:30663117 + pubmed:30116051 - path(MESH:"Parkinson Disease") decreases g(HGNC:MIR205) + path(MESH:"Alzheimer Disease") decreases p(HGNC:SIRT1) - pmid:30663117 + pubmed:30116051 - path(MESH:"Parkinson Disease") decreases p(HGNC:PARK7) + path(MESH:"Alzheimer Disease") positiveCorrelation g(HGNC:PSEN1, var("?")) - pmid:30663117 + pubmed:26195256 - path(MESH:"Parkinson Disease") increases g(HGNC:MIR494) + path(MESH:"Alzheimer Disease") association g(HGNC:PSEN1, var("?")) - pmid:30663117 + pubmed:30116051 - path(MESH:"Parkinson Disease") decreases g(HGNC:MIR34B) + path(MESH:"Alzheimer Disease") negativeCorrelation a(CHEBI:"selenium(2+)") - pmid:30663117 + pubmed:30116051 - path(MESH:"Parkinson Disease") decreases g(HGNC:MIR34C) + path(MESH:"Alzheimer Disease") increases act(p(HGNC:ABL1)) - pmid:19126755 + pubmed:30116051 - path(MESH:"Parkinson Disease") association p(HBP:"alpha-6 alpha-4 beta-2 beta-3 nAChR", loc(MESH:"Basal Ganglia")) + path(MESH:"Alzheimer Disease") decreases p(HGNC:IDE) - pmid:19126755 + pubmed:30116051 - path(MESH:"Parkinson Disease") positiveCorrelation path(MESH:Tremor) + path(MESH:"Alzheimer Disease") decreases p(HGNC:MME) - pmid:19126755 + pubmed:30116051 - path(MESH:"Parkinson Disease") positiveCorrelation path(MESH:Hypokinesia) + path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PLG) - pmid:19126755 + pubmed:29024336 - path(MESH:"Parkinson Disease") positiveCorrelation path(MESH:"Muscle Rigidity") + path(MESH:"Alzheimer Disease") increases path(MESH:"Proteostasis Deficiencies") - pmid:19126755 + pubmed:29215007 - path(MESH:"Parkinson Disease") negativeCorrelation path(MESH:"Tobacco Use Disorder") + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, var("?")) - pmid:17009926 + pubmed:29980653 - path(MESH:"Parkinson Disease") negativeCorrelation act(p(FPLX:CHRN)) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, var("?")) - pmid:17009926 + pubmed:24027553 - path(MESH:"Parkinson Disease") negativeCorrelation p(FPLX:CHRN) + path(MESH:"Alzheimer Disease") association p(HGNC:PIN1) - pmid:11230871 + pubmed:24027553 - path(MESH:"Parkinson Disease") association p(FPLX:CHRN) + path(MESH:"Alzheimer Disease") increases a(CHEBI:Thrombin, loc(MESH:Microvessels)) - pmid:26813123 + pubmed:24027553 - path(MESH:"Parkinson Disease") negativeCorrelation a(MESH:"Cholinergic Neurons") + path(MESH:"Alzheimer Disease") increases a(CHEBI:Thrombin, loc(MESH:"Cerebrospinal Fluid")) - pmid:24590577 + pubmed:24027553 - path(MESH:"Parkinson Disease") association p(HGNC:CHRM4) + path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:Thrombin, loc(MESH:Neurons)) - pmid:24590577 + pubmed:24027553 - path(MESH:"Parkinson Disease") decreases act(a(MESH:"Dopaminergic Neurons")) + path(MESH:"Alzheimer Disease") positiveCorrelation a(CHEBI:Thrombin, loc(MESH:Astrocytes)) - pmid:21722302 + pubmed:24027553 - path(MESH:"Parkinson Disease") decreases a(MESH:"Dopaminergic Neurons") + path(MESH:"Alzheimer Disease") association bp(CONSO:"APP processing") - pmid:24762290 + pubmed:24027553 - path(MESH:"Parkinson Disease") decreases path(MESH:Memory) + path(MESH:"Alzheimer Disease") association p(HGNC:HTRA1) - pmid:24762290 + pubmed:24027553 - path(MESH:"Parkinson Disease") association path(MESH:Memory) + path(MESH:"Alzheimer Disease") increases act(p(HGNC:CAPN2)) - pmid:24762290 + pubmed:24027553 - path(MESH:"Parkinson Disease") association complex(HBP:"alpha-4 beta-2 nAChR") + path(MESH:"Alzheimer Disease") positiveCorrelation act(p(HGNC:CASP3)) - pmid:28901280 + pubmed:24027553 - path(MESH:"Parkinson Disease") association p(MESH:"Receptors, Nicotinic") + path(MESH:"Alzheimer Disease") positiveCorrelation act(p(HGNC:CASP6)) - pmid:22020111 + pubmed:24027553 - path(MESH:"Parkinson Disease") positiveCorrelation a(HBP:"protein aggregates") + path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"proteasomal protein catabolic process") - pmid:21722302 + pubmed:24027553 - path(MESH:"Parkinson Disease") association path(HBP:Neurodegeneration) + path(MESH:"Alzheimer Disease") increases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Proteasome)) - pmid:21722302 + pubmed:24027553 - path(MESH:"Parkinson Disease") association bp(HBP:"protein aggregation") + path(MESH:"Alzheimer Disease") positiveCorrelation a(MESH:Autophagosomes) - pmid:21722302 + pubmed:23528736 - path(MESH:"Parkinson Disease") association p(MESH:"parkin protein") + path(MESH:"Alzheimer Disease") increases a(MESH:Autophagosomes) - pmid:21722302 + pubmed:23528736 - path(MESH:"Parkinson Disease") association bp(GO:"parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization") + path(MESH:"Alzheimer Disease") increases a(MESH:Autophagosomes) - pmid:21722302 + pubmed:24027553 - path(MESH:"Parkinson Disease") association p(HGNC:PARK7, var("?")) + path(MESH:"Alzheimer Disease") positiveCorrelation a(MESH:Lysosomes) - pmid:21722302 + pubmed:24027553 - path(MESH:"Parkinson Disease") association a(MESH:Paraquat) + path(MESH:"Alzheimer Disease") decreases bp(MESH:Autophagy) - pmid:21722302 + pubmed:27574109 - path(MESH:"Parkinson Disease") decreases bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") + path(MESH:"Alzheimer Disease") positiveCorrelation p(CONSO:"phosphatase-activating domain") - pmid:21722302 + pubmed:21734277 - path(MESH:"Parkinson Disease") decreases bp(MESH:"Unfolded Protein Response") + path(MESH:"Alzheimer Disease") increases p(CONSO:"phosphatase-activating domain") - pmid:21722302 + pubmed:21734277 - path(MESH:"Parkinson Disease") increases bp(GO:"neuron death") + path(MESH:"Alzheimer Disease") increases p(CONSO:"phosphatase-activating domain") - pmid:14556719 + pubmed:27574109 - path(MESH:"Parkinson Disease") positiveCorrelation bp(GO:"neuron death") + path(MESH:"Alzheimer Disease") positiveCorrelation a(CONSO:"Tau oligomers") - pmid:29758300 + pubmed:27574109 - path(MESH:"Parkinson Disease") positiveCorrelation path(MESH:"Plaque, Amyloid") + path(MESH:"Alzheimer Disease") positiveCorrelation a(CONSO:"Tau oligomers") - pmid:29758300 + pubmed:25887395 - path(MESH:"Parkinson Disease") association p(HGNC:VPS35, var("?")) + path(MESH:"Alzheimer Disease") positiveCorrelation a(CONSO:"Tau oligomers") - pmid:29758300 + pubmed:28420982 - path(MESH:"Parkinson Disease") negativeCorrelation bp(GO:macroautophagy) + path(MESH:"Alzheimer Disease") positiveCorrelation a(CONSO:"Tau oligomers") - pmid:14556719 + pubmed:26631930 - path(MESH:"Parkinson Disease") negativeCorrelation bp(GO:"synaptic transmission, dopaminergic") + path(MESH:"Alzheimer Disease") positiveCorrelation a(CONSO:"Tau oligomers") - pmid:14556719 + pubmed:22817713 - path(MESH:"Parkinson Disease") negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + path(MESH:"Alzheimer Disease") increases a(CONSO:"Tau oligomers") - pmid:14556719 + pubmed:27574109 - path(MESH:"Parkinson Disease") positiveCorrelation p(HGNC:PRKN) + path(MESH:"Alzheimer Disease") positiveCorrelation composite(p(CONSO:"phosphatase-activating domain"), p(HGNC:MAPT)) - pmid:27181519 + pubmed:23528736 - path(MESH:"Parkinson Disease") association p(HGNC:PRKN) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:UBB) - pmid:14556719 + pubmed:23528736 - path(MESH:"Parkinson Disease") association p(HGNC:UCHL1, var("?")) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:UBC) - pmid:14556719 + pubmed:23528736 - path(MESH:"Parkinson Disease") association p(HGNC:UCHL1, var("p.Ile93Met")) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:UBA52) - pmid:14556719 + pubmed:23528736 - path(MESH:"Parkinson Disease") association a(MESH:"Lewy Bodies") + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:RPS27A) - pmid:14556719 + pubmed:23528736 - path(MESH:"Parkinson Disease") association p(HGNC:SNCA, var("p.Ala30Pro")) + path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNCGENEFAMILY:"Ubiquitin like modifier activating enzymes") - pmid:14556719 + pubmed:23528736 - path(MESH:"Parkinson Disease") association p(HGNC:SNCA, var("p.Ala53Thr")) + path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNCGENEFAMILY:"Ubiquitin conjugating enzymes E2") - pmid:22908190 + pubmed:23528736 - path(MESH:"Parkinson Disease") positiveCorrelation p(HGNC:SNCA, pmod(Ub)) + path(MESH:"Alzheimer Disease") association p(HGNC:STUB1) - pmid:22908190 + pubmed:29311797 - path(MESH:"Parkinson Disease") association p(HGNC:UCHL1) + path(MESH:"Alzheimer Disease") association p(HGNC:STUB1) - pmid:18930136 + pubmed:23528736 - path(MESH:"Parkinson Disease") positiveCorrelation a(GO:autophagosome) + path(MESH:"Alzheimer Disease") association p(HGNC:PRKN) - pmid:28803412 + pubmed:23528736 - path(MESH:"Parkinson Disease") association p(HGNC:SNCA) + path(MESH:"Alzheimer Disease") association p(HGNC:RNF182) - pmid:29980653 + pubmed:23528736 - path(MESH:"Parkinson Disease") positiveCorrelation p(HGNC:SNCA) + path(MESH:"Alzheimer Disease") association p(HGNC:UCHL1, var("?")) - pmid:28803412 + pubmed:23528736 - path(MESH:"Parkinson Disease") positiveCorrelation a(HBP:HBP00093) + path(MESH:"Alzheimer Disease") decreases bp(MESH:Proteolysis) - pmid:27075649 + pubmed:29988016 - path(MESH:"Parkinson Disease") positiveCorrelation a(HBP:HBP00016) + path(MESH:"Alzheimer Disease") positiveCorrelation a(CONSO:"Tau aggregates") - pmid:30116051 + pubmed:27373205 - path(MESH:"Parkinson Disease") association p(HGNC:PINK1, var("?")) + path(MESH:"Alzheimer Disease") positiveCorrelation a(CONSO:"Tau aggregates") - pmid:30116051 + pubmed:26631930 - path(MESH:"Parkinson Disease") association p(HGNC:PRKN, var("?")) + path(MESH:"Alzheimer Disease") positiveCorrelation a(CONSO:"Tau aggregates") - pmid:30116051 + pubmed:22817713 - path(MESH:"Parkinson Disease") association p(HGNC:LRRK2, var("?")) + path(MESH:"Alzheimer Disease") positiveCorrelation a(CONSO:"Tau aggregates") - pmid:29024336 + pubmed:21882945 - path(MESH:"Parkinson Disease") increases path(MESH:"Proteostasis Deficiencies") + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) - pmid:30985105 + pubmed:21882945 - path(MESH:"Parkinson Disease") positiveCorrelation deg(a(HBP:"Dopaminergic cell groups")) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:BAG1) - pmid:30985105 + pubmed:30126037 - path(MESH:"Parkinson Disease") association complex(p(HGNC:SNCA), p(HGNC:SNCA)) + path(MESH:"Alzheimer Disease") association bp(MESH:"Cerebrovascular Circulation") - pmid:30985105 + pubmed:22419736 - path(MESH:"Parkinson Disease") association act(p(HGNCGENEFAMILY:Calpains)) + path(MESH:"Alzheimer Disease") increases p(HGNC:AK1) - pmid:30985105 + pubmed:22419736 - path(MESH:"Parkinson Disease") association act(p(HGNCGENEFAMILY:Calpains)) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:AK1) - pmid:29311797 + pubmed:22419736 - path(MESH:"Parkinson Disease") association p(HGNC:STUB1) + path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:AMPK, pmod(go:0006468 ! "protein phosphorylation", Thr, 172)) - pmid:26751493 + pubmed:29191965 - path(MESH:"Parkinson Disease") association g(DBSNP:rs2471738) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) - pmid:26751493 + pubmed:30985105 - path(MESH:"Parkinson Disease") association g(DBSNP:rs242557) + path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:OGT)) - pmid:26631930 + pubmed:30985105 - path(MESH:"Parkinson Disease") increases a(CHEBI:"iron(0)") + path(MESH:"Alzheimer Disease") decreases p(HGNC:OGT) - pmid:29980653 + pubmed:25374103 - path(MESH:"Parkinson Disease") isA path(MESH:"Neurodegenerative Diseases") + path(MESH:"Alzheimer Disease") decreases complex(a(GO:microtubule), p(HGNC:MAPT)) - pmid:29980653 + pubmed:25374103 - path(MESH:"Parkinson Disease") isA path(MESH:"Lewy Body Disease") + path(MESH:"Alzheimer Disease") decreases p(HGNC:MAPT, pmod(CONSO:misfolded)) - pmid:30046111 + pubmed:28420982 - bp(GO:"excitatory chemical synaptic transmission") association act(a(MESH:"Lymphatic Vessels")) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 181)) - pmid:19293145 + pubmed:29311797 - bp(GO:learning) association path(MESH:"Alzheimer Disease") + path(MESH:"Alzheimer Disease") isA path(MESH:Tauopathies) - pmid:24511233 + pubmed:26631930 - bp(GO:learning) association a(MESH:Hippocampus) + path(MESH:"Alzheimer Disease") isA path(MESH:Tauopathies) - pmid:24511233 + pubmed:29311797 - bp(GO:learning) association a(MESH:Hippocampus) + path(MESH:"Alzheimer Disease") decreases p(HGNC:PPID) - pmid:24511233 + pubmed:29311797 - bp(GO:learning) association a(MESH:"Cerebral Cortex") + path(MESH:"Alzheimer Disease") increases p(HGNC:FKBP5) - pmid:24511233 + pubmed:29311797 - bp(GO:learning) association a(MESH:"Cerebral Cortex") + path(MESH:"Alzheimer Disease") decreases p(HGNC:FKBP4) - pmid:24511233 + pubmed:29311797 - bp(GO:learning) association bp(GO:"long-term synaptic potentiation") + path(MESH:"Alzheimer Disease") decreases act(p(HGNC:PPP5C)) - pmid:24511233 + pubmed:29311797 - bp(GO:learning) association a(MESH:"Prefrontal Cortex") + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:AHSA1) - pmid:17009926 + pubmed:26751493 - bp(GO:learning) association p(FPLX:CHRN) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) - pmid:26813123 + pubmed:26751493 - bp(GO:learning) association bp(GO:"synaptic transmission, cholinergic") + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 68)) - pmid:26813123 + pubmed:26751493 - bp(GO:learning) positiveCorrelation bp(GO:"synaptic transmission, cholinergic") + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 69)) - pmid:21482353 + pubmed:26751493 - bp(GO:learning) association bp(GO:"synaptic transmission, cholinergic") + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 71)) - pmid:26813123 + pubmed:26751493 - bp(GO:learning) association a(CHEBI:acetylcholine) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 113)) - pmid:24590577 + pubmed:26751493 - bp(GO:learning) association p(HGNC:CHRM1) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 123)) - pmid:19721446 + pubmed:26751493 - bp(GO:learning) association p(HGNC:CHRNA7) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 153)) - pmid:30106381 + pubmed:26751493 - bp(GO:learning) association p(HGNC:ADNP) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 175)) - pmid:30106381 + pubmed:26751493 - bp(GO:learning) association a(PUBCHEM:9832404) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 184)) - pmid:22908190 + pubmed:26751493 - bp(GO:learning) association bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 185)) - pmid:24355211 + pubmed:26751493 - bp(GO:learning) negativeCorrelation p(HGNC:GSK3B) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 191)) - pmid:21843595 + pubmed:26751493 - bp(GO:learning) negativeCorrelation p(MGI:Sumo3) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 197)) - pmid:30046111 + pubmed:23088643 - bp(GO:"neuronal signal transduction") association act(a(MESH:"Lymphatic Vessels")) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 197)) - pmid:24590577 + pubmed:26751493 - bp(GO:"neuronal signal transduction") association p(HGNC:CHRM1) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 208)) - pmid:11230871 + pubmed:26751493 - bp(GO:"response to oxidative stress") negativeCorrelation p(FPLX:CHRN) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 210)) - pmid:14556719 + pubmed:26751493 - bp(GO:"response to oxidative stress") increases p(HGNC:SOD1, pmod(Ub), var("?")) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 214)) - pmid:14556719 + pubmed:26751493 - bp(GO:"response to oxidative stress") increases p(HGNC:SOD1, pmod(HBP:misfolding), var("?")) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 237)) - pmid:23746257 + pubmed:26751493 - bp(GO:"response to oxidative stress") increases a(MESH:"Heat-Shock Proteins") + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 238)) - pmid:23746257 + pubmed:26751493 - bp(GO:"response to oxidative stress") association bp(HBP:Proteostasis) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 258)) - pmid:18930136 + pubmed:26751493 - bp(GO:"response to oxidative stress") increases p(HGNC:SQSTM1) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 289)) - pmid:18930136 + pubmed:26751493 - bp(GO:"response to oxidative stress") increases r(HGNC:SQSTM1) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) - pmid:24563850 + pubmed:26751493 - bp(GO:"response to oxidative stress") decreases act(p(HGNC:KEAP1)) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 394)) - pmid:24563850 + pubmed:26751493 - bp(GO:"response to oxidative stress") increases p(HGNC:NFE2L2) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 403)) - pmid:24563850 + pubmed:26751493 - bp(GO:"response to oxidative stress") increases act(p(FPLX:PRDX)) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 409)) - pmid:27671637 + pubmed:26751493 - bp(GO:"response to oxidative stress") negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 435)) - pmid:23528736 + pubmed:26751493 - bp(GO:"response to oxidative stress") increases bp(GO:autophagy) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 427)) - pmid:22419736 + pubmed:26751493 - bp(GO:"response to oxidative stress") increases p(HGNC:AK1) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 433)) - pmid:26751493 + pubmed:26195256 - bp(GO:"response to oxidative stress") association a(CHEBI:"methylene blue") + path(MESH:"Alzheimer Disease") association g(HGNC:PSEN2, var("?")) - pmid:26751493 + pubmed:26195256 - bp(GO:"response to oxidative stress") association a(CHEBI:"azure A") + path(MESH:"Alzheimer Disease") association g(HGNC:APP, var("?")) - pmid:26751493 + pubmed:26195256 - bp(GO:"response to oxidative stress") association a(CHEBI:"azure B") + path(MESH:"Alzheimer Disease") association p(HGNC:TREM2, var("?")) - pmid:27181519 + pubmed:26195256 - bp(GO:"response to oxidative stress") increases complex(GO:"cytoplasmic stress granule") + path(MESH:"Alzheimer Disease") association p(HGNC:CLU, var("?")) - pmid:30126037 + pubmed:26195256 - bp(GO:"cellular respiration") association act(a(MESH:Mitochondria)) + path(MESH:"Alzheimer Disease") negativeCorrelation a(MESH:"Cerebral Cortex") - pmid:30046111 + pubmed:26195256 - bp(GO:"immune response") association bp(GO:aging) + path(MESH:"Alzheimer Disease") positiveCorrelation a(MESH:"Cerebral Ventricles") - pmid:27288790 + pubmed:26195256 - bp(GO:"immune response") association m(MIRBASE:"hsa-mir-146a") + path(MESH:"Alzheimer Disease") negativeCorrelation p(MESH:Neprilysin) - pmid:30106381 + pubmed:26195256 - bp(GO:"immune response") association p(HGNC:ADNP) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MMP2) - pmid:30106381 + pubmed:26195256 - bp(GO:"immune response") association a(PUBCHEM:9832404) + path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:LRP1) - pmid:23746257 + pubmed:26195256 - bp(GO:"immune response") association p(FPLX:HSP90) + path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:ABCB1) - pmid:30046111 + pubmed:29626319 - bp(GO:"inflammatory response") association bp(GO:aging) + path(MESH:"Alzheimer Disease") decreases p(HGNC:ABCB1) - pmid:29179999 + pubmed:26195256 - bp(GO:"inflammatory response") association act(p(FPLX:NFkappaB)) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:AGER) - pmid:27522251 + pubmed:26195256 - bp(GO:"inflammatory response") causesNoChange path(MESH:"Memory Disorders") + path(MESH:"Alzheimer Disease") negativeCorrelation a(MESH:"Cerebrospinal Fluid") - pmid:23746257 + pubmed:26195256 - bp(GO:"inflammatory response") association bp(HBP:Proteostasis) + path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:AQP1)) - pmid:24563850 + pubmed:26195256 - bp(GO:"inflammatory response") increases a(CHEBI:"reactive oxygen species") + path(MESH:"Alzheimer Disease") increases path(MESH:"Calcification, Physiologic") - pmid:16566606 + pubmed:26195256 - bp(GO:"inflammatory response") increases a(CHEBI:"reactive oxygen species") + path(MESH:"Alzheimer Disease") increases path(MESH:Fibrosis) - pmid:8940412 + pubmed:26631930 - bp(GO:"inflammatory response") positiveCorrelation act(p(RGD:Crh)) + path(MESH:"Alzheimer Disease") decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 259)) - pmid:8940412 + pubmed:26631930 - bp(GO:"inflammatory response") negativeCorrelation a(CHEBI:antalarmin) + path(MESH:"Alzheimer Disease") decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 290)) - pmid:30126037 + pubmed:26631930 - bp(GO:"inflammatory response") association bp(GO:"cellular senescence") + path(MESH:"Alzheimer Disease") decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 321)) - pmid:18494933 + pubmed:26631930 - bp(GO:"inflammatory response") increases p(HGNC:DKK1) + path(MESH:"Alzheimer Disease") decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 353)) - pmid:16566606 + pubmed:26631930 - bp(GO:"inflammatory response") increases a(CHEBI:"reactive nitrogen species") + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) - pmid:16566606 + pubmed:29276758 - bp(GO:"inflammatory response") increases a(CHEBI:peroxynitrite) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) - pmid:30046111 + pubmed:21427723 - bp(GO:"phospholipid metabolic process") association bp(GO:aging) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) - pmid:30046111 + pubmed:26631930 - bp(GO:"extracellular matrix organization") association bp(GO:aging) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 174)) - pmid:30046111 + pubmed:26631930 - bp(GO:"cell adhesion") association bp(GO:aging) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006487 ! "protein N-linked glycosylation")) - pmid:21214928 + pubmed:26631930 - bp(GO:"cell adhesion") association p(HGNC:APP) + path(MESH:"Alzheimer Disease") decreases p(HGNC:MAPT, pmod(go:0006493 ! "protein O-linked glycosylation")) - pmid:28901280 + pubmed:26631930 - bp(GO:"cell adhesion") association a(MESH:Acetylcholine) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 18)) - pmid:30106381 + pubmed:26631930 - bp(GO:"cell adhesion") association p(HGNC:ADNP) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) - pmid:30106381 + pubmed:17050703 - bp(GO:"cell adhesion") association a(PUBCHEM:9832404) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) - pmid:30046111 + pubmed:26631930 - bp(GO:"endothelial tube morphogenesis") association bp(GO:aging) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 394)) - pmid:10998059 + pubmed:26631930 - act(p(MGI:Cdk5r1)) increases p(MGI:Ppp1r1b, pmod(Ph)) + path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation")) - pmid:19118186 + pubmed:26631930 - p(MGI:Cdk5r1) increases act(p(MGI:Cdk5)) + path(MESH:"Alzheimer Disease") increases p(HGNC:MAPT, frag("?")) + + + + + + + pubmed:26631930 + + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, frag("26_230")) - pmid:27087442 + pubmed:26631930 - p(MGI:Cdk5r1) decreases bp(GO:"neuron death") + path(MESH:"Alzheimer Disease") increases a(CHEBI:"iron(0)") - pmid:30046111 + pubmed:22817713 - p(MGI:Vegfc) increases a(MESH:"Lymphatic Vessels") + path(MESH:"Alzheimer Disease") association a(MESH:"Neuropil Threads") - pmid:30046111 + pubmed:29626319 - p(MGI:Vegfc) increases act(a(MESH:"Lymphatic Vessels")) + path(MESH:"Alzheimer Disease") decreases bp(GO:"lysosomal microautophagy") - pmid:30046111 + pubmed:29626319 - p(MGI:Vegfc) increases a(MESH:"Lymphatic Vessels") + path(MESH:"Alzheimer Disease") positiveCorrelation act(p(HGNC:ACE)) - pmid:30046111 + pubmed:29626319 - p(MGI:Vegfc) increases a(MESH:"Lymphatic Vessels") + path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:SERPINF2) - pmid:30046111 + pubmed:29626319 - p(MGI:Vegfc) increases act(a(MESH:"Lymphatic Vessels")) + path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:SERPINF2)) - pmid:30046111 + pubmed:29626319 - p(MGI:Vegfc) causesNoChange a(MESH:"Lymphatic Vessels") + path(MESH:"Alzheimer Disease") decreases tloc(a(CHEBI:water), fromLoc(GO:"extracellular region"), toLoc(MESH:"Cerebrospinal Fluid")) + + + pubmed:25974414 + + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, var("p.Asp13*")) + + - pmid:30046111 + pubmed:25974414 - p(MGI:Vegfc) increases path(MESH:"Spatial Learning") + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, var("p.Asp25*")) - pmid:30046111 + pubmed:25974414 - p(MGI:Vegfc) increases bp(GO:"stem cell proliferation") + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, var("p.Asp368*")) - pmid:30046111 + pubmed:25974414 - p(MGI:Vegfc) increases bp(GO:cognition) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, var("p.Glu391*")) - pmid:30046111 + pubmed:25974414 - p(MGI:Vegfc) increases tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Cerebrospinal Fluid"), toLoc(MESH:"Lymph Nodes")) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, var("p.Asp421*")) - pmid:30046111 + pubmed:24869773 - p(MGI:Vegfc) causesNoChange tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Cerebrospinal Fluid"), toLoc(MESH:"Lymph Nodes")) + path(MESH:"Alzheimer Disease") association p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 311)) - pmid:30046111 + pubmed:23531502 - p(MGI:Vegfc) causesNoChange a(CHEBI:"amyloid-beta") + path(MESH:"Alzheimer Disease") positiveCorrelation act(a(CHEBI:acrolein)) - pmid:30046111 + pubmed:19251756 - p(MGI:Vegfc) causesNoChange path(HP:"Abnormal lymphatic vessel morphology") + path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"canonical glycolysis") + + + pubmed:19251756 + + path(MESH:"Alzheimer Disease") negativeCorrelation a(CHEBI:ATP) + + + + + pubmed:19251756 + + path(MESH:"Alzheimer Disease") positiveCorrelation p(INTERPRO:"Triosephosphate isomerase", pmod(go:0017014 ! "protein nitrosylation", Tyr, 164)) + + - pmid:30046111 + pubmed:19251756 - composite(a(CHEBI:"poly(ethylene glycol dimethacrylate)"), p(MGI:Vegfc)) increases a(MESH:"Lymphatic Vessels") + path(MESH:"Alzheimer Disease") positiveCorrelation p(INTERPRO:"Triosephosphate isomerase", pmod(go:0017014 ! "protein nitrosylation", Tyr, 208)) - pmid:30046111 + pubmed:11738469 - p(MGI:Vegfc, var("p.Cys156Ser")) increases a(MESH:"Lymphatic Vessels") + path(MESH:"Alzheimer Disease") positiveCorrelation act(p(ECCODE:2.3.2.13)) - pmid:30046111 + pubmed:8985134 - p(MGI:Vegfc, var("p.Cys156Ser")) increases tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Cerebrospinal Fluid"), toLoc(MESH:Brain)) + path(MESH:"Alzheimer Disease") positiveCorrelation act(p(ECCODE:2.3.2.13)) - pmid:30046111 + pubmed:9099822 - path(MESH:Inflammation) negativeCorrelation act(a(MESH:"Lymphatic Vessels")) + path(MESH:"Alzheimer Disease") increases act(p(HGNCGENEFAMILY:Transglutaminases)) - pmid:21329555 + pubmed:20096481 - path(MESH:Inflammation) positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs2651206) - pmid:27288790 + pubmed:21548880 - path(MESH:Inflammation) positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs2651206) - pmid:24027553 + pubmed:20096481 - path(MESH:Inflammation) positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs10807287) - pmid:21329555 + pubmed:20096481 - path(MESH:Inflammation) association bp(GO:"NIK/NF-kappaB signaling") + path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs7764257) - pmid:27288790 + pubmed:11943212 - path(MESH:Inflammation) association p(FPLX:NFkappaB) + path(MESH:"Alzheimer Disease") positiveCorrelation path(CONSO:"granulovacuolar degeneration") - pmid:22040696 + pubmed:23666762 - path(MESH:Inflammation) increases path(MESH:"Renal Insufficiency") + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MARK4) - pmid:30106381 + pubmed:23666762 - path(MESH:Inflammation) association p(HGNC:ADNP) + path(MESH:"Alzheimer Disease") positiveCorrelation complex(p(HGNC:MAPT), p(HGNC:MARK4)) - pmid:30012004 + pubmed:28176663 - path(MESH:Inflammation) positiveCorrelation path(MESH:"Huntington Disease") + path(MESH:"Alzheimer Disease") increases r(HGNC:GSK3B) - pmid:24027553 + pubmed:26118667 - path(MESH:Inflammation) increases act(p(HGNCGENEFAMILY:Caspases)) + path(MESH:"Alzheimer Disease") positiveCorrelation p(CONSO:"CDK5R1 p25") - pmid:26195256 + pubmed:21910444 - path(MESH:Inflammation) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + path(MESH:"Alzheimer Disease") increases p(HGNC:MAPK1) - pmid:26195256 + pubmed:21910444 - path(MESH:Inflammation) decreases deg(a(CHEBI:"amyloid-beta")) + path(MESH:"Alzheimer Disease") increases p(HGNC:PRKCB) - pmid:29255009 + pubmed:24401760 - p(MGI:Fkbp1b) increases path(MESH:Memory) + path(MESH:"Alzheimer Disease") increases p(HGNC:ITPKB) - pmid:29255009 + pubmed:24401760 - p(MGI:Fkbp1b) increases bp(MESH:Aging) + path(MESH:"Alzheimer Disease") positiveCorrelation path(CONSO:Astrogliosis) - pmid:29255009 + pubmed:24401760 - p(MGI:Fkbp1b) increases act(p(MGI:Eif3g)) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:APP, frag("672_711")) - pmid:29255009 + pubmed:29540553 - p(MGI:Fkbp1b) increases act(p(MGI:Pla2g7)) + path(MESH:"Alzheimer Disease") negativeCorrelation p(MGI:Sirt3) - pmid:29255009 + pubmed:29559585 - p(MGI:Fkbp1b) increases act(p(MGI:S100b)) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:GAPDH, pmod(go:0017014 ! "protein nitrosylation")) - pmid:29255009 + pubmed:21427723 - p(MGI:Fkbp1b) increases act(p(MGI:Snapc2)) + path(MESH:"Alzheimer Disease") isA path(CONSO:"4R tauopathy") - pmid:29255009 + pubmed:19732809 - p(MGI:Fkbp1b) increases bp(MESH:"Facilitated Diffusion") + path(MESH:"Alzheimer Disease") negativeCorrelation p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) - pmid:29255009 + pubmed:19732809 - p(MGI:Fkbp1b) increases bp(GO:"ectoderm development") + path(MESH:"Alzheimer Disease") positiveCorrelation g(HGNC:OGA, var("?")) - pmid:29255009 + pubmed:27716675 - p(MGI:Fkbp1b) increases bp(GO:"regulation of actin cytoskeleton organization") + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SUMO1) - pmid:29255009 + pubmed:19765634 - p(MGI:Fkbp1b) increases act(p(MESH:"Mitogen-Activated Protein Kinases")) + path(MESH:"Alzheimer Disease") positiveCorrelation g(DBSNP:rs761059) - pmid:29255009 + pubmed:29062069 - p(MGI:Fkbp1b) decreases act(p(MESH:"Membrane Transport Proteins")) + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MID1) - pmid:29255009 + pubmed:25001178 - p(MGI:Fkbp1b) decreases bp(GO:"blood vessel development") + path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:DUSP6) - pmid:29255009 + pubmed:25001178 - p(MGI:Fkbp1b) decreases bp(GO:"regulation of cellular component movement") + path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:PPP1CA) - pmid:29255009 + pubmed:29281045 - p(MGI:Fkbp1b) decreases a(GO:"cytoplasmic vesicle") + path(MESH:"Alzheimer Disease") decreases p(HGNC:LCMT1) - pmid:29255009 + pubmed:29281045 - p(MGI:Fkbp1b) decreases tloc(a(CHEBI:"calcium(2+)")) + path(MESH:"Alzheimer Disease") increases p(HGNC:PPME1) - pmid:29255009 + pubmed:24964035 - p(MGI:Fkbp1b) regulates p(MGI:Capn1) + path(MESH:"Alzheimer Disease") negativeCorrelation p(FPLX:SMAD) - pmid:29255009 + pubmed:23157676 - p(MGI:Fkbp1b) regulates p(MGI:Ppp3cc) + path(MESH:"Alzheimer Disease") positiveCorrelation p(CONSO:"cis p-tau") - pmid:29255009 + pubmed:30837838 - p(MGI:Fkbp1b) decreases p(MGI:Hif1an) + path(MESH:"Alzheimer Disease") association p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation"), loc(GO:"inclusion body")) - pmid:29255009 + pubmed:30837838 - p(MGI:Fkbp1b) decreases p(MGI:Nfkb1) + path(MESH:"Alzheimer Disease") association p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination"), loc(GO:"inclusion body")) + + + + + + + pubmed:26091809 + + path(MESH:"Alzheimer Disease") increases path(MESH:Mortality) + + + + + + + pubmed:24561250 + + path(MESH:"Alzheimer Disease") association complex(GO:"NLRP3 inflammasome complex") + + + + + + + pubmed:24561250 + + path(MESH:"Alzheimer Disease") positiveCorrelation bp(GO:aging) + + + + + + + pubmed:24561250 + + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:PYCARD) + + + + + + + pubmed:24561250 + + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:NLRC4) - pmid:24762290 + pubmed:24561250 - path(MESH:Memory) association path(MESH:"Parkinson Disease") + path(MESH:"Alzheimer Disease") association complex(GO:"IPAF inflammasome complex") - pmid:24762290 + pubmed:27314526 - path(MESH:Memory) association complex(HBP:"alpha-4 beta-2 nAChR") + path(MESH:"Alzheimer Disease") association complex(GO:"inflammasome complex") - pmid:28901280 + pubmed:27314526 - path(MESH:Memory) association p(MESH:"Receptors, Nicotinic") + path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:P2RX7) - pmid:29255009 + pubmed:25514383 - p(HBP:"AAV-FKBP1B") increases p(MGI:Fkbp1b, loc(MESH:Hippocampus)) + bp(GO:"neuron cellular homeostasis") association complex(a(CHEBI:amyloid-beta), p(FPLX:CHRN)) - pmid:29255009 + pubmed:30988501 - bp(MESH:Aging) decreases p(MGI:Map2) + bp(GO:"neuron cellular homeostasis") increases p(HGNCGENEFAMILY:"Purinergic receptors P2X", loc(MESH:Microglia)) - pmid:29255009 + pubmed:30988501 - bp(MESH:Aging) regulates p(MGI:Capn1) + bp(GO:"neuron cellular homeostasis") increases p(HGNCGENEFAMILY:"Glutamate metabotropic receptors", loc(MESH:Microglia)) - pmid:29255009 + pubmed:30046111 - bp(MESH:Aging) regulates p(MGI:Ppp3cc) + bp(GO:aging) decreases bp(GO:"cerebrospinal fluid circulation") - pmid:24511233 + pubmed:30046111 - bp(MESH:Aging) association path(MESH:"Alzheimer Disease") + bp(GO:aging) decreases act(a(HP:"interstitial fluid")) - pmid:23528736 + pubmed:30046111 - bp(MESH:Aging) increases path(MESH:"Alzheimer Disease") + bp(GO:aging) increases a(CHEBI:amyloid-beta) - pmid:25437566 + pubmed:29626319 - bp(MESH:Aging) increases p(HGNC:TPR) + bp(GO:aging) positiveCorrelation a(CHEBI:amyloid-beta) - pmid:25437566 + pubmed:29421605 - bp(MESH:Aging) increases p(HGNC:TPR) + bp(GO:aging) positiveCorrelation a(CHEBI:amyloid-beta) - pmid:25437566 + pubmed:30046111 - bp(MESH:Aging) increases p(HGNC:TPR) + bp(GO:aging) decreases act(a(MESH:"Lymphatic Vessels")) - pmid:27491084 + pubmed:30046111 - bp(MESH:Aging) increases p(HGNC:TPR) + bp(GO:aging) negativeCorrelation act(a(MESH:"Lymphatic Vessels")) - pmid:25437566 + pubmed:30046111 - bp(MESH:Aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") + bp(GO:aging) decreases tloc(a(CHEBI:macromolecule), fromLoc(GO:"extracellular space"), toLoc(MESH:"Intracellular Space")) - pmid:25437566 + pubmed:30046111 - bp(MESH:Aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") + bp(GO:aging) association bp(GO:"immune response") - pmid:25437566 + pubmed:30046111 - bp(MESH:Aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") + bp(GO:aging) association bp(GO:"inflammatory response") - pmid:25437566 + pubmed:30046111 - bp(MESH:Aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") + bp(GO:aging) association bp(GO:"phospholipid metabolic process") - pmid:27491084 + pubmed:30046111 - bp(MESH:Aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") + bp(GO:aging) association bp(GO:"extracellular matrix organization") - pmid:25784053 + pubmed:30046111 - bp(MESH:Aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") + bp(GO:aging) association bp(GO:"cell adhesion") - pmid:25437566 + pubmed:30046111 - bp(MESH:Aging) decreases p(FPLX:HSPA) + bp(GO:aging) association bp(GO:"endothelial tube morphogenesis") - pmid:25437566 + pubmed:30046111 - bp(MESH:Aging) decreases p(FPLX:HSPA) + bp(GO:aging) decreases p(MGI:Cdk5r1) - pmid:27491084 + pubmed:30046111 - bp(MESH:Aging) decreases p(FPLX:HSPA) + bp(GO:aging) decreases p(MGI:Adamts3) - pmid:25784053 + pubmed:30046111 - bp(MESH:Aging) decreases p(FPLX:HSPA) + bp(GO:aging) decreases p(MGI:Fgfr3) - pmid:25437566 + pubmed:26551702 - bp(MESH:Aging) increases p(FPLX:HSPB) + bp(GO:aging) negativeCorrelation a(MESH:Glutathione) - pmid:25437566 + pubmed:28760828 - bp(MESH:Aging) increases p(FPLX:HSPB) + bp(GO:aging) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262), pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) - pmid:27491084 + pubmed:21427723 - bp(MESH:Aging) increases p(FPLX:HSPB) + bp(GO:aging) positiveCorrelation p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 280)) - pmid:25784053 + pubmed:25031639 - bp(MESH:Aging) increases p(FPLX:HSPB) + bp(GO:aging) decreases p(CONSO:"KXGS motif", pmod(go:0006473 ! "protein acetylation")) - pmid:25437566 + pubmed:25031639 - bp(MESH:Aging) decreases p(HGNC:HSPD1) + bp(GO:aging) increases p(CONSO:"KXGS motif", pmod(CONSO:hyperphosphorylation)) - pmid:27491084 + pubmed:25031639 - bp(MESH:Aging) decreases p(HGNC:HSPD1) + bp(GO:aging) decreases p(HGNC:MAPT) - pmid:25437566 + pubmed:30145931 - bp(MESH:Aging) increases p(HGNC:HSPA2) + bp(GO:aging) increases p(HGNC:MAPT) - pmid:25437566 + pubmed:30145931 - bp(MESH:Aging) increases p(HGNC:DNAJB2) + bp(GO:aging) decreases p(HGNC:MAPT) - pmid:25437566 + pubmed:21882945 - bp(MESH:Aging) decreases p(HGNC:HSPA12A) + bp(GO:aging) negativeCorrelation deg(p(HGNC:MAPT)) - pmid:25437566 + pubmed:29238289 - bp(MESH:Aging) decreases p(HGNC:TOMM70) + bp(GO:aging) increases p(HGNC:MAPT) - pmid:25437566 + pubmed:29196815 - bp(MESH:Aging) decreases p(HGNC:HSP90AB1) + bp(GO:aging) increases path(MESH:"Alzheimer Disease") - pmid:25437566 + pubmed:24561250 - bp(MESH:Aging) decreases p(HGNC:HSPA8) + bp(GO:aging) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:25437566 + pubmed:29196815 - bp(MESH:Aging) decreases p(HGNC:HSPA14) + bp(GO:aging) increases a(CONSO:CONSO00074) - pmid:25437566 + pubmed:26979166 - bp(MESH:Aging) decreases p(HGNC:TCP1) + bp(GO:aging) negativeCorrelation bp(GO:"microglial cell mediated cytotoxicity") - pmid:25784053 + pubmed:25514383 - bp(MESH:Aging) regulates bp(HBP:Proteostasis) + bp(GO:aging) association path(MESH:Dementia) - pmid:25784053 + pubmed:27522251 - bp(MESH:Aging) decreases p(FPLX:HSP90) + bp(GO:aging) association p(MGI:Chrna7) - pmid:29311797 + pubmed:18986241 - bp(MESH:Aging) increases p(FPLX:HSP90) + bp(GO:aging) increases p(HGNC:NGFR) - pmid:29311797 + pubmed:11230871 - bp(MESH:Aging) decreases p(FPLX:HSP90) + bp(GO:aging) negativeCorrelation complex(a(CHEBI:epibatidine), p(FPLX:CHRN)) - pmid:29311797 + pubmed:11230871 - bp(MESH:Aging) decreases p(FPLX:HSP90) + bp(GO:aging) negativeCorrelation complex(a(CHEBI:epibatidine), p(FPLX:CHRN)) - pmid:23528736 + pubmed:11230871 - bp(MESH:Aging) decreases bp(GO:autophagy) + bp(GO:aging) causesNoChange r(HGNC:CHRNA3) - pmid:23528736 + pubmed:4255369 - bp(MESH:Aging) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + bp(GO:aging) positiveCorrelation a(CONSO:"Tau fibrils") - pmid:28420982 + pubmed:4255369 - bp(MESH:Aging) association tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"cell body")) + bp(GO:aging) positiveCorrelation a(CONSO:"Tau oligomers") - pmid:28420982 + pubmed:31413141 - bp(MESH:Aging) association tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:dendrite)) + bp(GO:aging) positiveCorrelation p(HGNC:TREM2, frag("?")) - pmid:29311797 + pubmed:23454242 - bp(MESH:Aging) association path(MESH:"Neurodegenerative Diseases") + bp(GO:aging) increases p(HGNC:PPP2R2C) - pmid:29311797 + pubmed:23454242 - bp(MESH:Aging) decreases bp(GO:"protein folding") + bp(GO:aging) decreases p(HGNC:PPP2R2B) - pmid:29311797 + pubmed:28083634 - bp(MESH:Aging) increases path(MESH:"Protein Aggregation, Pathological") + bp(GO:aging) increases p(MGI:Otub1) - pmid:29311797 + pubmed:27491084 - bp(MESH:Aging) decreases bp(MESH:Proteolysis) + bp(GO:aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") - pmid:29311797 + pubmed:27491084 - bp(MESH:Aging) decreases act(p(FPLX:Proteasome)) + bp(GO:aging) decreases p(FPLX:HSPA) - pmid:29311797 + pubmed:27491084 - bp(MESH:Aging) decreases act(p(FPLX:Proteasome)) + bp(GO:aging) increases p(FPLX:HSPB) - pmid:29311797 + pubmed:30562574 - bp(MESH:Aging) decreases bp(GO:"chaperone-mediated autophagy") + bp(GO:aging) negativeCorrelation p(HGNC:LAMP2) - pmid:29311797 + pubmed:30562574 - bp(MESH:Aging) decreases bp(GO:"chaperone-mediated autophagy") + bp(GO:aging) decreases bp(GO:"chaperone-mediated autophagy") - pmid:29311797 + pubmed:30562574 - bp(MESH:Aging) decreases p(HGNC:PPID) + bp(GO:aging) association bp(GO:"chaperone-mediated autophagy") - pmid:29311797 + pubmed:14556719 - bp(MESH:Aging) decreases p(HGNC:PPID) + bp(GO:aging) negativeCorrelation act(complex(GO:"proteasome complex")) - pmid:29311797 + pubmed:22908190 - bp(MESH:Aging) increases p(HGNC:FKBP5) + bp(GO:aging) negativeCorrelation act(complex(GO:"proteasome complex")) - pmid:29311797 + pubmed:22908190 - bp(MESH:Aging) increases p(HGNC:FKBP5) + bp(GO:aging) negativeCorrelation act(complex(GO:"proteasome complex")) - pmid:29311797 + pubmed:14556719 - bp(MESH:Aging) decreases p(HGNC:PPP5C) + bp(GO:aging) negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:29311797 + pubmed:14556719 - bp(MESH:Aging) decreases p(HGNC:PPP5C) + bp(GO:aging) increases p(HGNC:PRNP) - pmid:29311797 + pubmed:23746257 - bp(MESH:Aging) decreases p(HGNC:AHSA1) + bp(GO:aging) decreases bp(CONSO:Proteostasis) - pmid:29311797 + pubmed:23746257 - bp(MESH:Aging) decreases p(HGNC:AHSA1) + bp(GO:aging) decreases bp(CONSO:Proteostasis) - pmid:29311797 + pubmed:24563850 - bp(MESH:Aging) decreases p(HGNC:FKBP4) + bp(GO:aging) positiveCorrelation bp(CONSO:"non-enzymatic protein modification") - pmid:29311797 + pubmed:24563850 - bp(MESH:Aging) decreases p(HGNC:STIP1) + bp(GO:aging) association bp(GO:"protein oxidation") - pmid:29311797 + pubmed:30116051 - bp(MESH:Aging) decreases p(HGNC:PTGES3) + bp(GO:aging) negativeCorrelation act(p(HGNC:SIRT1)) - pmid:29311797 + pubmed:30116051 - bp(MESH:Aging) increases p(FPLX:HSP90, pmod(Ph)) + bp(GO:aging) decreases a(CHEBI:"NAD(+)") - pmid:29311797 + pubmed:29024336 - bp(MESH:Aging) increases p(FPLX:HSP90, pmod(Ac)) + bp(GO:aging) increases path(MESH:"Proteostasis Deficiencies") - pmid:29311797 + pubmed:29024336 - bp(MESH:Aging) increases p(FPLX:HSP90, pmod(NO)) + bp(GO:aging) increases path(MESH:"Proteostasis Deficiencies") - pmid:29311797 + pubmed:21882945 - bp(MESH:Aging) increases p(FPLX:HSP90, pmod(Ub)) + bp(GO:aging) positiveCorrelation p(HGNC:FKBP5) - pmid:29255009 + pubmed:29191965 - p(MGI:Eif3g) increases bp(MESH:Aging) + bp(GO:aging) decreases bp(GO:locomotion) - pmid:29255009 + pubmed:28877763 - p(MGI:Pla2g7) increases bp(MESH:Aging) + bp(GO:aging) increases p(MGI:Syk, pmod(go:0006468 ! "protein phosphorylation")) - pmid:29255009 + pubmed:28877763 - p(MGI:S100b) increases bp(MESH:Aging) + bp(GO:aging) increases p(MGI:Syk, pmod(go:0006468 ! "protein phosphorylation")) - pmid:29255009 + pubmed:28877763 - p(MGI:Snapc2) increases bp(MESH:Aging) + bp(GO:aging) increases a(CONSO:"Tau aggregates") - pmid:29255009 + pubmed:26631930 - path(MESH:Aging) decreases bp(MESH:"Facilitated Diffusion") + bp(GO:aging) positiveCorrelation a(CONSO:"Tau aggregates") - pmid:29255009 + pubmed:28877763 - path(MESH:Aging) decreases bp(GO:"ectoderm development") + bp(GO:aging) increases p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) - pmid:29255009 + pubmed:29626319 - path(MESH:Aging) decreases bp(GO:"regulation of actin cytoskeleton organization") + bp(GO:aging) negativeCorrelation p(HGNC:IDE) - pmid:29255009 + pubmed:25681682 - path(MESH:Aging) decreases act(p(MESH:"Mitogen-Activated Protein Kinases")) + bp(GO:aging) negativeCorrelation p(HGNC:AGER) - pmid:29255009 + pubmed:19118186 - path(MESH:Aging) increases act(p(MESH:"Membrane Transport Proteins")) + bp(GO:aging) decreases bp(GO:memory) - pmid:29255009 + pubmed:28877763 - path(MESH:Aging) increases bp(GO:"blood vessel development") + bp(GO:aging) increases a(CONSO:"dystrophic neurite") - pmid:29255009 + pubmed:29421605 - path(MESH:Aging) increases bp(GO:"regulation of cellular component movement") + bp(GO:aging) positiveCorrelation p(RGD:Ptpn1) - pmid:29255009 + pubmed:29421605 - path(MESH:Aging) increases a(GO:"cytoplasmic vesicle") + bp(GO:aging) negativeCorrelation p(RGD:Irs1, pmod(go:0006468 ! "protein phosphorylation")) - pmid:29255009 + pubmed:29421605 - path(MESH:Aging) increases p(MGI:Hif1an) + bp(GO:aging) negativeCorrelation p(RGD:Akt1, pmod(go:0006468 ! "protein phosphorylation")) - pmid:29255009 + pubmed:29421605 - path(MESH:Aging) increases p(MGI:Nfkb1) + bp(GO:aging) negativeCorrelation p(RGD:Gsk3b, pmod(go:0006468 ! "protein phosphorylation")) - pmid:19126755 + pubmed:29421605 - path(MESH:Aging) negativeCorrelation p(HBP:"alpha-4 beta-2 nAChR") + bp(GO:aging) negativeCorrelation p(RGD:Mtor, pmod(go:0006468 ! "protein phosphorylation")) - pmid:19126755 + pubmed:29421605 - path(MESH:Aging) negativeCorrelation p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + bp(GO:aging) negativeCorrelation p(RGD:Ntrk2, pmod(go:0006468 ! "protein phosphorylation")) - pmid:19126755 + pubmed:29421605 - path(MESH:Aging) decreases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + bp(GO:aging) positiveCorrelation p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation")) - pmid:19126755 + pubmed:24561250 - path(MESH:Aging) decreases p(MGI:Chrna4) + bp(GO:aging) increases act(complex(GO:"NLRP1 inflammasome complex")) - pmid:19126755 + pubmed:24561250 - path(MESH:Aging) negativeCorrelation p(MGI:Chrna4) + bp(GO:aging) increases p(HGNC:IL1B) - pmid:19126755 + pubmed:24561250 - path(MESH:Aging) negativeCorrelation p(MGI:Chrna7) + bp(GO:aging) increases p(HGNC:IL18) - pmid:26195256 + pubmed:30046111 - path(MESH:Aging) increases path(MESH:"Alzheimer Disease") + bp(GO:"cerebrospinal fluid circulation") decreases a(CHEBI:amyloid-beta) - pmid:26195256 + pubmed:30046111 - path(MESH:Aging) negativeCorrelation a(MESH:"Cerebrospinal Fluid") + act(a(HP:"interstitial fluid")) decreases a(CHEBI:amyloid-beta) - pmid:26195256 + pubmed:30046111 - path(MESH:Aging) negativeCorrelation act(p(HGNC:AQP1)) + a(MESH:"Lymphatic Vessels") regulates bp(MESH:Homeostasis) - pmid:19126755 + pubmed:30046111 - a(CHEBI:"calcium(2+)", loc(GO:intracellular)) increases act(p(FPLX:CREB), ma(tscript)) + a(MESH:"Lymphatic Vessels") increases tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Cerebrospinal Fluid"), toLoc(MESH:"Lymph Nodes")) - pmid:19126755 + pubmed:30046111 - a(CHEBI:"calcium(2+)", loc(GO:intracellular)) increases a(CHEBI:anandamide) + act(a(MESH:"Lymphatic Vessels")) association tloc(a(CHEBI:macromolecule), fromLoc(GO:"extracellular space"), toLoc(MESH:"Intracellular Space")) - pmid:19126755 + pubmed:30046111 - a(CHEBI:"calcium(2+)", loc(GO:intracellular)) regulates bp(GO:"signal release") + act(a(MESH:"Lymphatic Vessels")) increases tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Parenchymal Tissue"), toLoc(MESH:"Lymph Nodes")) - pmid:19126755 + pubmed:30046111 - a(CHEBI:"calcium(2+)", loc(GO:intracellular)) regulates bp(MESH:"Neuronal Plasticity") + act(a(MESH:"Lymphatic Vessels")) increases tloc(a(CHEBI:macromolecule), fromLoc(HP:"interstitial fluid"), toLoc(MESH:"Lymph Nodes")) - pmid:19126755 + pubmed:30046111 - a(CHEBI:"calcium(2+)", loc(GO:intracellular)) regulates bp(GO:"neuron migration") + act(a(MESH:"Lymphatic Vessels")) increases tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Cerebrospinal Fluid"), toLoc(MESH:"Parenchymal Tissue")) - pmid:22040696 + pubmed:30046111 - tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:Cytoplasm)) increases bp(GO:"neuron migration") + act(a(MESH:"Lymphatic Vessels")) increases bp(MESH:"Cerebrovascular Circulation") - pmid:19126755 + pubmed:30046111 - a(CHEBI:"calcium(2+)", loc(GO:intracellular)) regulates bp(GO:"neuron differentiation") + act(a(MESH:"Lymphatic Vessels")) increases bp(MESH:"Cerebrovascular Circulation") - pmid:19293145 + pubmed:30046111 - a(CHEBI:"calcium(2+)") association act(p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors")) + act(a(MESH:"Lymphatic Vessels")) association bp(MESH:"Cerebrovascular Circulation") - pmid:23038257 + pubmed:30046111 - a(CHEBI:"calcium(2+)") increases act(p(MESH:"Receptors, Nicotinic")) + act(a(MESH:"Lymphatic Vessels")) positiveCorrelation bp(MESH:"Cerebrovascular Circulation") - pmid:17009926 + pubmed:30046111 - tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Intracellular Space"), toLoc(GO:cytosol)) + act(a(MESH:"Lymphatic Vessels")) increases bp(GO:"cerebrospinal fluid secretion") - pmid:26472524 + pubmed:30046111 - tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) increases bp(GO:"membrane depolarization") + act(a(MESH:"Lymphatic Vessels")) increases tloc(a(CHEBI:"gadolinium atom"), fromLoc(GO:"extracellular space"), toLoc(MESH:"Cerebrospinal Fluid")) - pmid:26472524 + pubmed:30046111 - a(CHEBI:"calcium(2+)") regulates act(p(FPLX:CHRN)) + act(a(MESH:"Lymphatic Vessels")) increases bp(GO:"fear response") - pmid:26813123 + pubmed:30046111 - a(CHEBI:"calcium(2+)") regulates p(FPLX:CHRN) + act(a(MESH:"Lymphatic Vessels")) increases path(MESH:"Spatial Learning") - pmid:26813123 + pubmed:30046111 - a(CHEBI:"calcium(2+)") increases tloc(a(CHEBI:"glutamate(2-)"), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) + act(a(MESH:"Lymphatic Vessels")) increases path(MESH:"Spatial Learning") - pmid:26813123 + pubmed:30046111 - a(CHEBI:"calcium(2+)") increases tloc(a(CHEBI:"gamma-aminobutyric acid"), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) + act(a(MESH:"Lymphatic Vessels")) increases bp(GO:memory) - pmid:26813123 + pubmed:30046111 - a(CHEBI:"calcium(2+)") increases tloc(a(CHEBI:dopamine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) + act(a(MESH:"Lymphatic Vessels")) increases bp(GO:memory) - pmid:26813123 + pubmed:30046111 - a(CHEBI:"calcium(2+)") increases tloc(a(CHEBI:serotonin), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) + act(a(MESH:"Lymphatic Vessels")) association bp(GO:"gene expression") - pmid:26813123 + pubmed:30046111 - a(CHEBI:"calcium(2+)") increases tloc(a(CHEBI:noradrenaline), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) + act(a(MESH:"Lymphatic Vessels")) association path(MESH:"Huntington Disease") - pmid:26813123 + pubmed:30046111 - a(CHEBI:"calcium(2+)") increases tloc(a(CHEBI:acetylcholine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) + act(a(MESH:"Lymphatic Vessels")) association path(MESH:"Parkinson Disease") - pmid:26088141 + pubmed:30046111 - a(CHEBI:"calcium(2+)") association act(a(MESH:"Calcium Channels")) + act(a(MESH:"Lymphatic Vessels")) association path(MESH:"Alzheimer Disease") - pmid:19721446 + pubmed:30046111 - a(CHEBI:"calcium(2+)") increases act(p(HGNC:CHRNA7)) + act(a(MESH:"Lymphatic Vessels")) association bp(GO:"excitatory chemical synaptic transmission") - pmid:19721446 + pubmed:30046111 - a(CHEBI:"calcium(2+)") increases act(p(HBP:"alpha-4 beta-2 nAChR")) + act(a(MESH:"Lymphatic Vessels")) increases bp(GO:learning) - pmid:24027553 + pubmed:30046111 - a(CHEBI:"calcium(2+)") increases act(p(HGNCGENEFAMILY:Calpains)) + act(a(MESH:"Lymphatic Vessels")) increases bp(GO:cognition) - pmid:24027553 + pubmed:30046111 - a(CHEBI:"calcium(2+)", loc(GO:intracellular)) increases act(p(HGNCGENEFAMILY:Calpains)) + act(a(MESH:"Lymphatic Vessels")) association bp(GO:"neuronal signal transduction") - pmid:24027553 + pubmed:30046111 - a(CHEBI:"calcium(2+)", loc(GO:intracellular)) increases act(p(HGNCGENEFAMILY:Calpains)) + act(a(MESH:"Lymphatic Vessels")) regulates a(CHEBI:metabolite) - pmid:2123288 + pubmed:30046111 - a(CHEBI:"calcium(2+)") increases act(p(FPLX:CALM)) + act(a(MESH:"Lymphatic Vessels")) regulates bp(MESH:Glycolysis) - pmid:2833519 + pubmed:30046111 - a(CHEBI:"calcium(2+)") increases act(p(HGNC:S100B)) + act(a(MESH:"Lymphatic Vessels")) regulates bp(GO:"response to oxidative stress") - pmid:10537045 + pubmed:30046111 - a(CHEBI:"calcium(2+)") positiveCorrelation complex(p(HGNC:MAPT), p(HGNC:TGM2)) + act(a(MESH:"Lymphatic Vessels")) regulates bp(GO:"cellular respiration") - pmid:23702978 + pubmed:30046111 - a(CHEBI:"calcium(2+)") association p(HGNC:MAP3K7) + act(a(MESH:"Lymphatic Vessels")) negativeCorrelation bp(GO:aging) - pmid:23702978 + pubmed:30046111 - tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) increases act(p(HGNC:NLRP3)) + act(a(MESH:"Lymphatic Vessels")) increases act(p(MGI:Vegfc)) - pmid:19118186 + pubmed:30046111 - p(MGI:Capn1) negativeCorrelation p(MGI:Ttbk1) + act(a(MESH:"Lymphatic Vessels")) decreases a(CHEBI:amyloid-beta) - pmid:29255009 + pubmed:30046111 - a(CHEBI:sirolimus) decreases bp(HBP:"PI3K-Akt signaling pathway") + act(a(MESH:"Lymphatic Vessels")) negativeCorrelation a(CHEBI:amyloid-beta) - pmid:30061532 + pubmed:30046111 - a(CHEBI:sirolimus) decreases act(p(HGNC:MTOR)) + act(a(MESH:"Lymphatic Vessels")) decreases a(CHEBI:amyloid-beta) - pmid:29758300 + pubmed:30046111 - a(CHEBI:sirolimus) decreases act(p(HGNC:MTOR)) + act(a(MESH:"Lymphatic Vessels")) decreases a(CHEBI:amyloid-beta) - pmid:18930136 + pubmed:30046111 - a(CHEBI:sirolimus) decreases act(p(HGNC:MTOR)) + a(MESH:"Lymphatic Vessels") decreases a(CHEBI:amyloid-beta) - pmid:30985105 + pubmed:30046111 - a(CHEBI:sirolimus) decreases act(p(HGNC:MTOR)) + act(a(MESH:"Lymphatic Vessels")) decreases bp(GO:"macrophage migration") - pmid:30061532 + pubmed:30046111 - a(CHEBI:sirolimus) decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + act(a(MESH:"Lymphatic Vessels")) decreases a(MESH:Macrophages) - pmid:30061532 + pubmed:30046111 - a(CHEBI:sirolimus) decreases p(HGNC:SNCA, pmod(HBP:misfolded)) + act(a(MESH:"Lymphatic Vessels")) negativeCorrelation path(MESH:Inflammation) - pmid:30061532 + pubmed:30046111 - a(CHEBI:sirolimus) decreases p(HGNC:TARDBP, pmod(HBP:misfolded)) + act(a(MESH:"Lymphatic Vessels")) decreases a(CONSO:CONSO00018) - pmid:30061532 + pubmed:30967783 - a(CHEBI:sirolimus) increases path(MESH:"Interpersonal Relations") + bp(MESH:Homeostasis) increases a(MESH:Monocytes) - pmid:30061532 + pubmed:30967783 - a(CHEBI:sirolimus) increases bp(GO:behavior) + bp(MESH:Homeostasis) increases bp(GO:"microglial cell activation") - pmid:30061532 + pubmed:30046111 - a(CHEBI:sirolimus) decreases act(a(CHEBI:methamphetamine)) + tloc(a(CHEBI:macromolecule), fromLoc(GO:"extracellular space"), toLoc(MESH:"Intracellular Space")) association act(a(MESH:"Lymphatic Vessels")) - pmid:30061532 + pubmed:30046111 - a(CHEBI:sirolimus) decreases path(MESH:"Psychotic Disorders") + a(CHEBI:verteporfin) decreases a(MESH:"Lymphatic Vessels") - pmid:30061532 + pubmed:30046111 - a(CHEBI:sirolimus) decreases path(MESH:"Psychotic Disorders") + a(CHEBI:verteporfin) decreases act(a(MESH:"Lymphatic Vessels")) - pmid:30061532 + pubmed:30046111 - a(CHEBI:sirolimus) increases bp(GO:autophagy) + a(CHEBI:verteporfin) decreases bp(MESH:"Cerebrovascular Circulation") - pmid:29758300 + pubmed:30046111 - a(CHEBI:sirolimus) increases bp(GO:autophagy) + a(CHEBI:verteporfin) decreases tloc(a(CHEBI:"gadolinium atom"), fromLoc(GO:"extracellular space"), toLoc(MESH:"Cerebrospinal Fluid")) - pmid:22908190 + pubmed:30046111 - a(CHEBI:sirolimus) increases bp(GO:autophagy) + bp(MESH:"Cerebrovascular Circulation") association act(a(MESH:"Lymphatic Vessels")) - pmid:22908190 + pubmed:30046111 - a(CHEBI:sirolimus) increases bp(GO:autophagy) + bp(MESH:"Cerebrovascular Circulation") increases act(a(MESH:"Lymphatic Vessels")) - pmid:18930136 + pubmed:30046111 - a(CHEBI:sirolimus) increases bp(GO:autophagy) + bp(MESH:"Cerebrovascular Circulation") positiveCorrelation act(a(MESH:"Lymphatic Vessels")) - pmid:30116051 + pubmed:30046111 - a(CHEBI:sirolimus) increases bp(GO:autophagy) + bp(MESH:"Cerebrovascular Circulation") increases tloc(a(CHEBI:macromolecule), fromLoc(GO:"extracellular space"), toLoc(MESH:"Intracellular Space")) - pmid:23528736 + pubmed:30126037 - a(CHEBI:sirolimus) increases bp(GO:autophagy) + bp(MESH:"Cerebrovascular Circulation") association p(MGI:Mapt, var("p.Pro301Leu")) - pmid:29626319 + pubmed:30126037 - a(CHEBI:sirolimus) increases bp(GO:autophagy) + bp(MESH:"Cerebrovascular Circulation") association path(MESH:"Alzheimer Disease") - pmid:27181519 + pubmed:30126037 - a(CHEBI:sirolimus) increases bp(GO:autophagy) + bp(MESH:"Cerebrovascular Circulation") association path(MESH:"Cognitive Dysfunction") - pmid:30061532 + pubmed:30046111 - a(CHEBI:sirolimus) decreases path(MESH:Schizophrenia) + p(MGI:Aqp4) regulates tloc(a(CHEBI:macromolecule), fromLoc(GO:"extracellular space"), toLoc(MESH:"Intracellular Space")) - pmid:29758300 + pubmed:30046111 - a(CHEBI:sirolimus) increases bp(GO:cognition) + p(MGI:Aqp4) regulates tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Intracellular Space"), toLoc(GO:"extracellular space")) - pmid:29758300 + pubmed:30046111 - a(CHEBI:sirolimus) decreases a(CHEBI:"amyloid-beta") + p(MGI:Aqp4) decreases a(CHEBI:amyloid-beta) - pmid:29758300 + pubmed:30046111 - a(CHEBI:sirolimus) decreases a(CHEBI:"amyloid-beta") + p(MGI:Aqp4) increases bp(GO:cognition) - pmid:22908190 + pubmed:27889190 - a(CHEBI:sirolimus) decreases a(CHEBI:"amyloid-beta") + bp(GO:cognition) association path(DOID:"multiple sclerosis") - pmid:29626319 + pubmed:27889190 - a(CHEBI:sirolimus) decreases a(CHEBI:"amyloid-beta") + bp(GO:cognition) association path(DOID:"acute disseminated encephalomyelitis") - pmid:29758300 + pubmed:25031639 - a(CHEBI:sirolimus) increases bp(GO:macroautophagy) + bp(GO:cognition) positiveCorrelation g(HGNC:HDAC6) - pmid:29758300 + pubmed:25031639 - a(CHEBI:sirolimus) increases bp(GO:macroautophagy) + bp(GO:cognition) positiveCorrelation a(CHEBI:"epothilone D") - pmid:26751493 + pubmed:30270813 - a(CHEBI:sirolimus) increases bp(GO:macroautophagy) + bp(GO:cognition) negativeCorrelation a(CHEBI:cisplatin) - pmid:29758300 + pubmed:29661268 - a(CHEBI:sirolimus) decreases p(HGNC:MAPT) + bp(GO:cognition) positiveCorrelation a(CHEBI:"lithium atom") - pmid:23528736 + pubmed:22236693 - a(CHEBI:sirolimus) increases deg(p(HGNC:MAPT)) + bp(GO:cognition) negativeCorrelation g(HGNC:NGFR) - pmid:29758300 + pubmed:21036197 - a(CHEBI:sirolimus) increases bp(GO:"motor behavior") + bp(GO:cognition) association g(HGNC:NR3C2) - pmid:27181519 + pubmed:24586483 - a(CHEBI:sirolimus) increases bp(GO:"motor behavior") + bp(GO:cognition) negativeCorrelation g(DBSNP:rs57095329) - pmid:22908190 + pubmed:26235064 - a(CHEBI:sirolimus) decreases path(MESH:Tauopathies) + bp(GO:cognition) association p(HGNC:MAPT) - pmid:22908190 + pubmed:19126755 - a(CHEBI:sirolimus) decreases path(MESH:Tauopathies) + bp(GO:cognition) positiveCorrelation p(CONSO:"alpha-4 beta-2 nAChR") - pmid:25784053 + pubmed:21482353 - a(CHEBI:sirolimus) decreases act(p(FPLX:mTORC1)) + bp(GO:cognition) positiveCorrelation p(CONSO:"alpha-4 beta-2 nAChR") - pmid:25784053 + pubmed:19126755 - a(CHEBI:sirolimus) decreases path(MESH:"Protein Aggregation, Pathological") + bp(GO:cognition) positiveCorrelation p(HGNC:CHRNA7) - pmid:25784053 + pubmed:19126755 - a(CHEBI:sirolimus) decreases path(MESH:"Huntington Disease") + bp(GO:cognition) association act(p(HGNC:CHRNA7)) - pmid:18930136 + pubmed:27190210 - a(CHEBI:sirolimus) decreases path(MESH:"Huntington Disease") + bp(GO:cognition) association p(HGNC:CHRNA7) - pmid:25784053 + pubmed:19721446 - a(CHEBI:sirolimus) decreases path(MESH:"Machado-Joseph Disease") + bp(GO:cognition) positiveCorrelation p(HGNC:CHRNA7) - pmid:25784053 + pubmed:19126755 - a(CHEBI:sirolimus) decreases path(MESH:"Alzheimer Disease") + bp(GO:cognition) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:25784053 + pubmed:24511233 - a(CHEBI:sirolimus) decreases path(MESH:"Parkinson Disease") + bp(GO:cognition) association path(MESH:"Alzheimer Disease") - pmid:25784053 + pubmed:11230871 - a(CHEBI:sirolimus) decreases path(MESH:"Amyotrophic Lateral Sclerosis") + bp(GO:cognition) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:18930136 + pubmed:24511233 - a(CHEBI:sirolimus) decreases path(MESH:"Bulbo-Spinal Atrophy, X-Linked") + bp(GO:cognition) association path(MESH:Schizophrenia) - pmid:27594586 + pubmed:19721446 - a(CHEBI:sirolimus) decreases bp(GO:"TOR signaling") + bp(GO:cognition) association path(MESH:Schizophrenia) - pmid:27594586 + pubmed:24511233 - a(CHEBI:sirolimus) increases r(HGNC:MMP9) + bp(GO:cognition) association a(MESH:Hippocampus) - pmid:27594586 + pubmed:24511233 - a(CHEBI:sirolimus) increases r(HGNC:MMP2) + bp(GO:cognition) association a(MESH:"Cerebral Cortex") - pmid:30116051 + pubmed:24511233 - a(CHEBI:sirolimus) decreases p(HGNC:SNCA) + bp(GO:cognition) association bp(GO:"synaptic transmission, cholinergic") - pmid:27181519 + pubmed:26813123 - a(CHEBI:sirolimus) increases deg(p(HGNC:SNCA)) + bp(GO:cognition) association bp(GO:"synaptic transmission, cholinergic") - pmid:30116051 + pubmed:21482353 - a(CHEBI:sirolimus) decreases p(HGNC:FUS) + bp(GO:cognition) association bp(GO:"synaptic transmission, cholinergic") - pmid:27181519 + pubmed:24511233 - a(CHEBI:sirolimus) decreases p(HGNC:FUS, loc(GO:"cytoplasmic stress granule")) + bp(GO:cognition) association p(HGNC:CHRM1) - pmid:30116051 + pubmed:24511233 - a(CHEBI:sirolimus) decreases p(HGNC:HTT) + bp(GO:cognition) association p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits") - pmid:27181519 + pubmed:24511233 - a(CHEBI:sirolimus) increases deg(p(HGNC:HTT)) + bp(GO:cognition) association a(MESH:"Prefrontal Cortex") - pmid:24027553 + pubmed:27190210 - a(CHEBI:sirolimus) increases bp(MESH:Autophagy) + bp(GO:cognition) association g(HGNC:CHRNA7) - pmid:29626319 + pubmed:26813123 - a(CHEBI:sirolimus) decreases p(HGNC:MAPT, pmod(Ph)) + bp(GO:cognition) association bp(GO:"synaptic transmission, glutamatergic") - pmid:27181519 + pubmed:30697142 - a(CHEBI:sirolimus) increases deg(complex(GO:"cytoplasmic stress granule")) + bp(GO:cognition) positiveCorrelation bp(GO:"synaptic transmission, glutamatergic") - pmid:27181519 + pubmed:26813123 - a(CHEBI:sirolimus) increases bp(GO:locomotion) + bp(GO:cognition) association a(CHEBI:acetylcholine) - pmid:27181519 + pubmed:11230871 - a(CHEBI:sirolimus) increases a(MESH:Neurites) + bp(GO:cognition) negativeCorrelation a(CHEBI:acetylcholine) - pmid:27181519 + pubmed:25514383 - a(CHEBI:sirolimus) decreases bp(GO:"cell death") + bp(GO:cognition) association a(HP:"cholinergic neuron") - pmid:29255009 + pubmed:30697142 - bp(HBP:"PI3K-Akt signaling pathway") causesNoChange act(p(MGI:Fkbp1b)) + bp(GO:cognition) positiveCorrelation a(CHEBI:"(-)-cotinine") - pmid:28745240 + pubmed:30697142 - bp(HBP:"PI3K-Akt signaling pathway") increases act(complex(GO:"NF-kappaB complex")) + bp(GO:cognition) negativeCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:28745240 + pubmed:28445721 - bp(HBP:"PI3K-Akt signaling pathway") increases act(complex(GO:"NF-kappaB complex")) + bp(GO:cognition) association p(FPLX:CHRN) - + + + pubmed:28445721 + + bp(GO:cognition) association p(FPLX:CHRN) + - pmid:29255009 + pubmed:28445721 - act(complex(a(CHEBI:sirolimus), p(MGI:Fkbp1b))) decreases bp(HBP:"PI3K-Akt signaling pathway") + bp(GO:cognition) association p(FPLX:CHRN) - + + + pubmed:11230871 + + bp(GO:cognition) association p(FPLX:CHRN) + - pmid:29255009 + pubmed:21482353 - act(complex(a(CHEBI:sirolimus), p(MGI:Fkbp1a))) decreases bp(HBP:"PI3K-Akt signaling pathway") + bp(GO:cognition) positiveCorrelation p(HGNC:CHRNA5, var("?")) - pmid:29255009 + pubmed:21482353 - p(MGI:Fkbp1a) decreases bp(HBP:"PI3K-Akt signaling pathway") + bp(GO:cognition) positiveCorrelation p(HGNC:CHRNA3, var("?")) - pmid:30126037 + pubmed:21482353 - act(p(MGI:Nfkb1)) increases bp(MESH:"Cell Survival") + bp(GO:cognition) positiveCorrelation p(HGNC:CHRNB4, var("?")) - pmid:30126037 + pubmed:11230871 - act(p(MGI:Nfkb1)) increases bp(GO:"inflammatory response") + bp(GO:cognition) association complex(a(CHEBI:nicotine), p(FPLX:CHRN)) - pmid:30663117 + pubmed:11230871 - r(HGNC:BACE1, loc(GO:cytoplasm)) positiveCorrelation path(MESH:"Alzheimer Disease") + bp(GO:cognition) association a(CHEBI:neurotransmitter) - pmid:30663117 + pubmed:23516100 - r(HGNC:BACE1) increases path(MESH:"Alzheimer Disease") + bp(GO:cognition) negativeCorrelation p(HGNC:MAPT, frag("1_421")) - pmid:30663117 + pubmed:30108137 - r(HGNC:"BACE1-AS") biomarkerFor path(MESH:"Alzheimer Disease") + bp(GO:cognition) negativeCorrelation r(HGNC:TFEB) - pmid:30663117 + pubmed:22908190 - r(HGNC:"BACE1-AS") positiveCorrelation path(MESH:"Alzheimer Disease") + bp(GO:cognition) positiveCorrelation act(a(GO:synapse)) - pmid:30663117 + pubmed:24027553 - r(HGNC:"BACE1-AS") increases r(HGNC:BACE1) + bp(GO:cognition) negativeCorrelation p(CONSO:"Tau C3") - pmid:27288790 + pubmed:21882945 - r(HGNC:"BACE1-AS") regulates r(HGNC:BACE1) + bp(GO:cognition) negativeCorrelation path(MESH:Tauopathies) - pmid:27288790 + pubmed:21882945 - r(HGNC:"BACE1-AS") decreases deg(r(HGNC:BACE1)) + bp(GO:cognition) positiveCorrelation a(PUBCHEM:134222899) - pmid:30663117 + pubmed:21882945 - r(HGNC:"BACE1-AS") increases a(CHEBI:"amyloid-beta") + bp(GO:cognition) positiveCorrelation a(CHEBI:"NMDA receptor antagonist") - pmid:30663117 + pubmed:30985105 - r(HGNC:"BACE1-AS") increases path(MESH:"Plaque, Amyloid") + bp(GO:cognition) association a(CHEBI:amyloid-beta) - pmid:27288790 + pubmed:30988501 - r(HGNC:"BACE1-AS") regulates p(HGNC:BACE1) + bp(GO:cognition) association bp(MESH:"Immunity, Cellular") - pmid:27288790 + pubmed:30988501 - r(HGNC:"BACE1-AS") increases a(CHEBI:"amyloid-beta polypeptide 42") + bp(GO:cognition) association bp(MESH:"Immunity, Cellular") - pmid:25652642 + pubmed:30988501 - path(MESH:"Plaque, Amyloid") positiveCorrelation act(complex(GO:"NF-kappaB complex")) + bp(GO:cognition) association path(MESH:"Illness Behavior") - pmid:25652642 + pubmed:30988501 - path(MESH:"Plaque, Amyloid") association complex(GO:"NF-kappaB complex") + bp(GO:cognition) association path(MESH:Inflammation) - pmid:25652642 + pubmed:24808823 - path(MESH:"Plaque, Amyloid") association a(MESH:"HLA-DR Antigens") + path(MESH:"Spatial Learning") negativeCorrelation p(MGI:Ttbk1) - pmid:29196815 + pubmed:24808823 - path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:"Spatial Learning") negativeCorrelation p(MGI:Cdk5) - pmid:19126755 + pubmed:24808823 - path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:"Spatial Learning") positiveCorrelation tloc(p(MGI:Grin2b), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) - pmid:19293145 + pubmed:24107444 - path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Alzheimer Disease") + bp(GO:memory) positiveCorrelation p(MGI:Ncstn) - pmid:19293145 + pubmed:29179999 - path(MESH:"Plaque, Amyloid") biomarkerFor path(MESH:"Alzheimer Disease") + bp(GO:memory) association a(CHEBI:"amyloid-beta polypeptide 42") - pmid:19293145 + pubmed:29661268 - path(MESH:"Plaque, Amyloid") association path(MESH:"Alzheimer Disease") + bp(GO:memory) negativeCorrelation p(HGNC:MAPT, var("p.Lys?Gln")) - pmid:24511233 + pubmed:29661268 - path(MESH:"Plaque, Amyloid") biomarkerFor path(MESH:"Alzheimer Disease") + bp(GO:memory) negativeCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 274)) - pmid:24590577 + pubmed:29661268 - path(MESH:"Plaque, Amyloid") association path(MESH:"Alzheimer Disease") + bp(GO:memory) negativeCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 281)) - pmid:25514383 + pubmed:21673407 - path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Alzheimer Disease") + bp(GO:memory) association p(HGNC:HTR4) - pmid:22817713 + pubmed:30515821 - path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Alzheimer Disease") + bp(GO:memory) positiveCorrelation p(HGNC:DNM1) - pmid:19293145 + pubmed:19293145 - path(MESH:"Plaque, Amyloid") association p(HGNC:CHRNA7) + bp(GO:memory) association composite(p(HGNC:MAPK1), p(HGNC:MAPK3)) - pmid:19293145 + pubmed:24511233 - path(MESH:"Plaque, Amyloid") causesNoChange r(HGNC:CHRNA4) + bp(GO:memory) association a(MESH:Hippocampus) - pmid:19293145 + pubmed:24511233 - path(MESH:"Plaque, Amyloid") causesNoChange r(HGNC:CHRNA7) + bp(GO:memory) association a(MESH:Hippocampus) - pmid:24511233 + pubmed:19721446 - path(MESH:"Plaque, Amyloid") association a(HBP:"amyloid-beta aggregates") + bp(GO:memory) association a(MESH:Hippocampus) - pmid:26195256 + pubmed:24511233 - path(MESH:"Plaque, Amyloid") association a(HBP:"amyloid-beta aggregates") + bp(GO:memory) association a(MESH:"Cerebral Cortex") - pmid:24511233 + pubmed:24511233 - path(MESH:"Plaque, Amyloid") increases bp(HBP:neuroinflammation) + bp(GO:memory) association a(MESH:"Cerebral Cortex") - pmid:24511233 + pubmed:24511233 - path(MESH:"Plaque, Amyloid") increases bp(GO:"cell death") + bp(GO:memory) association bp(GO:"long-term synaptic potentiation") - pmid:24590577 + pubmed:24511233 - path(MESH:"Plaque, Amyloid") association bp(GO:"synaptic transmission, cholinergic") + bp(GO:memory) association a(MESH:"Prefrontal Cortex") - pmid:25514383 + pubmed:17009926 - path(MESH:"Plaque, Amyloid") association complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7)) + bp(GO:memory) association p(FPLX:CHRN) - pmid:29758300 + pubmed:11230871 - path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Parkinson Disease") + bp(GO:memory) association p(FPLX:CHRN) - pmid:14556719 + pubmed:22530628 - path(MESH:"Plaque, Amyloid") association a(MESH:"Amyloid beta-Peptides") + bp(GO:memory) association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:24027553 + pubmed:26813123 - path(MESH:"Plaque, Amyloid") association p(HGNC:MAP1LC3A) + bp(GO:memory) association bp(GO:"synaptic transmission, cholinergic") - pmid:28420982 + pubmed:21482353 - path(MESH:"Plaque, Amyloid") association a(MESH:Exosomes) + bp(GO:memory) association bp(GO:"synaptic transmission, cholinergic") - pmid:26195256 + pubmed:26813123 - path(MESH:"Plaque, Amyloid") negativeCorrelation act(p(HGNC:MMP2)) + bp(GO:memory) positiveCorrelation a(CHEBI:acetylcholine) - pmid:26195256 + pubmed:26813123 - path(MESH:"Plaque, Amyloid") increases act(a(MESH:Astrocytes)) + bp(GO:memory) association a(CHEBI:acetylcholine) - pmid:18562203 + pubmed:26813123 - path(MESH:"Plaque, Amyloid") association act(a(MESH:Astrocytes)) + bp(GO:memory) positiveCorrelation a(MESH:"Cholinergic Neurons") - pmid:23531502 + pubmed:26813123 - path(MESH:"Plaque, Amyloid") association act(a(CHEBI:acrolein)) + bp(GO:memory) negativeCorrelation path(CONSO:Neurodegeneration) - pmid:18562203 + pubmed:26813123 - path(MESH:"Plaque, Amyloid") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) + bp(GO:memory) association bp(MESH:"Synaptic Transmission") - pmid:26400044 + pubmed:26813123 - path(MESH:"Plaque, Amyloid") association complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt, pmod(Ph)), p(MGI:Wasf1, pmod(Ph))) + bp(GO:memory) association p(HGNC:SYP) - pmid:23088643 + pubmed:24590577 - path(MESH:"Plaque, Amyloid") association p(HBP:"Tau epitope, AT8") + bp(GO:memory) association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") - pmid:28877763 + pubmed:24590577 - path(MESH:"Plaque, Amyloid") association a(HBP:"dystrophic neurite") + bp(GO:memory) association p(HGNC:CHRM1) - pmid:24401760 + pubmed:19721446 - path(MESH:"Plaque, Amyloid") association a(HBP:"dystrophic neurite") + bp(GO:memory) association p(HGNC:CHRNA7) - pmid:28877763 + pubmed:19721446 - path(MESH:"Plaque, Amyloid") positiveCorrelation p(HGNC:SYK, pmod(Ph)) + bp(GO:memory) association a(MESH:"Entorhinal Cortex") - pmid:24401760 + pubmed:23516100 - path(MESH:"Plaque, Amyloid") positiveCorrelation p(HGNC:ITPKB) + bp(GO:memory) negativeCorrelation p(HGNC:CTSB) - pmid:30663117 + pubmed:30106381 - g(HGNC:"MIR124-1") decreases p(HGNC:BACE1) + bp(GO:memory) association p(HGNC:ADNP) - pmid:21329555 + pubmed:30012004 - p(HGNC:BACE1) positiveCorrelation path(MESH:"Alzheimer Disease") + bp(GO:memory) negativeCorrelation path(MESH:"Huntington Disease") - pmid:10656250 + pubmed:22908190 - p(HGNC:BACE1) increases sec(a(HBP:"sAPP-beta")) + bp(GO:memory) association bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:24590577 + pubmed:19118186 - p(HGNC:BACE1) increases a(HBP:"sAPP-beta") + bp(GO:memory) negativeCorrelation p(MGI:Mapt) - - - pmid:10656250 + pubmed:28775333 - p(HGNC:BACE1) causesNoChange sec(a(HBP:"sAPP-alpha")) + bp(GO:memory) positiveCorrelation a(CHEBI:"(-)-epigallocatechin 3-gallate") - pmid:10656250 + pubmed:28775333 - p(HGNC:BACE1) causesNoChange p(HGNC:APP) + bp(GO:memory) negativeCorrelation p(MGI:Dyrk1a) - pmid:10656250 + pubmed:24355211 - p(HGNC:BACE1, loc(GO:"endoplasmic reticulum")) association p(HGNC:APP, loc(GO:"endoplasmic reticulum")) + bp(GO:memory) negativeCorrelation p(HGNC:GSK3B) - pmid:24590577 + pubmed:27041503 - p(HGNC:BACE1) increases deg(p(HGNC:APP)) + bp(GO:memory) association p(HGNC:WWC1) - pmid:21718217 + pubmed:28771976 - p(HGNC:BACE1) decreases p(HGNC:APP) + bp(GO:memory) association a(CONSO:RGFP966) - pmid:10656250 + pubmed:21843595 - p(HGNC:BACE1) increases p(HGNC:APP, frag("672_770")) + bp(GO:memory) negativeCorrelation p(MGI:Sumo3) - pmid:10656250 + pubmed:30046111 - p(HGNC:BACE1) association a(HBP:APP695) + bp(GO:"gene expression") association act(a(MESH:"Lymphatic Vessels")) - pmid:10656250 + pubmed:30046111 - p(HGNC:BACE1) association a(HBP:APP751) + path(MESH:"Huntington Disease") association act(a(MESH:"Lymphatic Vessels")) - pmid:30444369 + pubmed:30663117 - p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta polypeptide 42"), p(HBP:"APP C-terminally truncated carboxyl-terminal fragments"))) + path(MESH:"Huntington Disease") association path(MESH:Chorea) - pmid:18650430 + pubmed:29687724 - act(p(HGNC:BACE1), ma(pep)) increases rxn(reactants(p(HGNC:APP)), products(p(HGNC:APP, frag("11_*")), p(HGNC:APP, frag("1_10")))) + path(MESH:"Huntington Disease") association path(MESH:Chorea) - + + + pubmed:30027901 + + path(MESH:"Huntington Disease") increases path(MESH:Chorea) + - + + + pubmed:30027901 + + path(MESH:"Huntington Disease") increases path(MESH:Chorea) + - pmid:21214928 + pubmed:30027901 - p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) + path(MESH:"Huntington Disease") increases path(MESH:Chorea) - pmid:21214928 + pubmed:30027901 - p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) + path(MESH:"Huntington Disease") increases path(MESH:Chorea) - pmid:21214928 + pubmed:30663117 - p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) + path(MESH:"Huntington Disease") association path(MESH:Dementia) - pmid:22122372 + pubmed:30012004 - p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) + path(MESH:"Huntington Disease") positiveCorrelation path(MESH:Dementia) - pmid:21722302 + pubmed:30027901 - p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) + path(MESH:"Huntington Disease") increases path(MESH:Dementia) - pmid:21214928 + pubmed:30663117 - p(HGNC:BACE1) increases bp(GO:"neuron death") + path(MESH:"Huntington Disease") association path(MESH:"Deglutition Disorders") - pmid:21214928 + pubmed:30663117 - p(HGNC:BACE1) decreases bp(GO:"synaptic transmission, cholinergic") + path(MESH:"Huntington Disease") association path(MESH:Aphasia) - pmid:21214928 + pubmed:30663117 - p(HGNC:BACE1) decreases bp(GO:memory) + path(MESH:"Huntington Disease") association path(MESH:Seizures) - pmid:21214928 + pubmed:30663117 - p(HGNC:BACE1) increases p(HGNC:APP, frag("672_713")) + path(MESH:"Huntington Disease") association g(HGNC:MIR196A1) - pmid:21214928 + pubmed:30663117 - p(HGNC:BACE1) increases p(HGNC:APP, frag("672_711")) + path(MESH:"Huntington Disease") increases g(HGNC:MIR196A1) - pmid:22122372 + pubmed:30663117 - p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00042), a(HBP:HBP00081))) + path(MESH:"Huntington Disease") association g(HGNC:MIR206) - pmid:22122372 + pubmed:30663117 - p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00042), a(HBP:HBP00081))) + path(MESH:"Huntington Disease") association g(HGNC:MIR301B) - pmid:22122372 + pubmed:30663117 - p(HGNC:BACE1) increases a(CHEBI:"amyloid-beta") + path(MESH:"Huntington Disease") association g(HGNC:MIR92B) - pmid:18986241 + pubmed:30663117 - act(p(HGNC:BACE1)) increases a(CHEBI:"amyloid-beta") + path(MESH:"Huntington Disease") association g(HGNC:MIR378B) - pmid:25331948 + pubmed:30663117 - p(HGNC:BACE1) increases a(CHEBI:"amyloid-beta") + path(MESH:"Huntington Disease") association g(HGNC:MIR208B) - pmid:26195256 + pubmed:30663117 - act(p(HGNC:BACE1)) increases a(CHEBI:"amyloid-beta") + path(MESH:"Huntington Disease") association g(HGNC:MIR449A) - pmid:29626319 + pubmed:30663117 - p(HGNC:BACE1) increases a(CHEBI:"amyloid-beta") + path(MESH:"Huntington Disease") decreases g(NCBIGENE:406915) - pmid:19126755 + pubmed:30663117 - p(HGNC:BACE1) increases a(CHEBI:"amyloid-beta polypeptide 42") + path(MESH:"Huntington Disease") increases g(MIRBASE:hsa-mir-10b) - pmid:24590577 + pubmed:30663117 - p(HGNC:BACE1) increases a(HBP:C99) + path(MESH:"Huntington Disease") increases g(HGNC:MIR196B) - pmid:21718217 + pubmed:30663117 - p(HGNC:BACE1) increases a(CHEBI:"amyloid-beta polypeptide 40") + path(MESH:"Huntington Disease") increases g(HGNC:MIR615) - pmid:29758300 + pubmed:30663117 - p(HGNC:BACE1) increases p(HGNC:APP, frag("?")) + path(MESH:"Huntington Disease") increases g(HGNC:MIR1247) - pmid:14556719 + pubmed:30663117 - p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta polypeptide 40"), a(CHEBI:"amyloid-beta polypeptide 42"))) + path(MESH:"Huntington Disease") decreases g(MGI:Mir22) - + + + pubmed:30663117 + + path(MESH:"Huntington Disease") decreases g(MGI:Mir29c) + - pmid:30663117 + pubmed:30663117 - complex(g(HGNC:"MIR124-1"), r(HGNC:BACE1)) decreases act(r(HGNC:BACE1)) + path(MESH:"Huntington Disease") decreases g(MGI:Mir128-1) - + + + pubmed:30663117 + + path(MESH:"Huntington Disease") decreases g(MGI:Mir132) + - pmid:30663117 + pubmed:30663117 - complex(g(HGNC:MIR15B), r(HGNC:BACE1)) decreases p(HGNC:BACE1) + path(MESH:"Huntington Disease") decreases g(MGI:Mir138-1) - + + + pubmed:30663117 + + path(MESH:"Huntington Disease") decreases g(MGI:Mir218-1) + - + + + pubmed:30663117 + + path(MESH:"Huntington Disease") decreases g(MGI:Mir222) + - pmid:30663117 + pubmed:30663117 - complex(g(HGNC:MIR339), r(HGNC:BACE1)) decreases p(HGNC:BACE1) + path(MESH:"Huntington Disease") decreases g(NCBIGENE:723931) - + + + pubmed:30663117 + + path(MESH:"Huntington Disease") decreases g(NCBIGENE:732489) + - pmid:30663117 + pubmed:26813123 - complex(g(HGNC:MIR384), r(HGNC:BACE1)) decreases p(HGNC:BACE1) + path(MESH:"Huntington Disease") negativeCorrelation act(p(HGNC:CHAT)) - pmid:30663117 + pubmed:30027901 - g(HGNC:MIR384) association path(MESH:"Alzheimer Disease") + path(MESH:"Huntington Disease") decreases act(p(HGNC:CHAT)) - + + + pubmed:30362565 + + path(MESH:"Huntington Disease") association path(MESH:"Neurodegenerative Diseases") + - pmid:30663117 + pubmed:29687724 - complex(g(HGNC:MIR384), r(HGNC:APP)) decreases p(HGNC:APP) + path(MESH:"Huntington Disease") association path(MESH:"Neurodegenerative Diseases") - pmid:30232325 + pubmed:30027901 - p(HGNC:APP) increases act(p(HGNC:WNT3A)) + path(MESH:"Huntington Disease") isA path(MESH:"Neurodegenerative Diseases") - pmid:30232325 + pubmed:30362565 - p(HGNC:APP) increases act(p(HGNC:WNT5A)) + path(MESH:"Huntington Disease") decreases act(p(HGNC:HTT)) - pmid:30232325 + pubmed:30362565 - p(HGNC:APP) increases bp(GO:"canonical Wnt signaling pathway") + path(MESH:"Huntington Disease") decreases path(MESH:"Organelle Biogenesis") - pmid:30232325 + pubmed:30362565 - p(HGNC:APP) increases bp(GO:"non-canonical Wnt signaling pathway") + path(MESH:"Huntington Disease") association path(MESH:Autophagy) - - - pmid:11230871 + pubmed:30362565 - act(p(HGNC:APP)) association p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) + path(MESH:"Huntington Disease") decreases path(MESH:"Mitochondrial Dynamics") - pmid:30232325 + pubmed:30362565 - p(HGNC:APP) increases act(p(HGNC:DKK1)) + path(MESH:"Huntington Disease") decreases path(MESH:"Protein Transport") - pmid:30232325 + pubmed:30362565 - p(HGNC:APP) increases act(p(HGNC:DKK1)) + path(MESH:"Huntington Disease") decreases a(CHEBI:ATP) - pmid:30232325 + pubmed:30012004 - p(HGNC:APP) increases bp(HBP:HBP00061) + path(MESH:"Huntington Disease") positiveCorrelation bp(GO:"neuron death") - - - pmid:10656250 + pubmed:30012004 - p(HGNC:APP, loc(GO:"endoplasmic reticulum")) association p(HGNC:BACE1, loc(GO:"endoplasmic reticulum")) + path(MESH:"Huntington Disease") positiveCorrelation bp(GO:"neuron death") - + + + pubmed:27013968 + + path(MESH:"Huntington Disease") increases bp(GO:"neuron death") + - + + + pubmed:30027901 + + path(MESH:"Huntington Disease") increases bp(GO:"neuron death") + - + + + pubmed:30012004 + + path(MESH:"Huntington Disease") positiveCorrelation path(MESH:Atrophy) + - pmid:18650430 + pubmed:30012004 - p(HGNC:APP) increases bp(GO:"regulation of cell growth") + path(MESH:"Huntington Disease") positiveCorrelation path(CONSO:Excitotoxicity) - pmid:18650430 + pubmed:30027901 - p(HGNC:APP) increases bp(GO:"synapse assembly") + path(MESH:"Huntington Disease") association path(CONSO:Excitotoxicity) - pmid:21214928 + pubmed:30012004 - p(HGNC:APP) association bp(GO:"synapse assembly") + path(MESH:"Huntington Disease") positiveCorrelation path(MESH:"Oxidative Stress") - pmid:18650430 + pubmed:30012004 - p(HGNC:APP) increases bp(MESH:"Neuronal Outgrowth") + path(MESH:"Huntington Disease") negativeCorrelation bp(MESH:"Energy Metabolism") - pmid:21214928 + pubmed:30012004 - p(HGNC:APP) association bp(MESH:"Neuronal Outgrowth") + path(MESH:"Huntington Disease") positiveCorrelation path(CONSO:"mitochondrial dysfunction") - pmid:18650430 + pubmed:30012004 - p(HGNC:APP) increases bp(GO:"cell adhesion") + path(MESH:"Huntington Disease") positiveCorrelation path(MESH:Inflammation) - pmid:21214928 + pubmed:30012004 - p(HGNC:APP) association bp(GO:"cell adhesion") + path(MESH:"Huntington Disease") positiveCorrelation bp(GO:"apoptotic process") - pmid:22122372 + pubmed:30012004 - p(HGNC:APP) increases bp(GO:"cell adhesion") + path(MESH:"Huntington Disease") positiveCorrelation bp(GO:autophagy) - pmid:18650430 + pubmed:30012004 - p(HGNC:APP) regulates act(p(HGNC:SLC5A7)) + path(MESH:"Huntington Disease") negativeCorrelation bp(GO:"dopamine metabolic process") - pmid:21214928 + pubmed:30012004 - p(HGNC:APP) increases a(CHEBI:"amyloid-beta") + path(MESH:"Huntington Disease") negativeCorrelation bp(GO:"D-glutamate metabolic process") - pmid:22122372 + pubmed:30012004 - p(HGNC:APP) increases a(CHEBI:"amyloid-beta") + path(MESH:"Huntington Disease") negativeCorrelation bp(GO:"cannabinoid biosynthetic process") - pmid:21722302 + pubmed:30012004 - p(HGNC:APP) increases a(CHEBI:"amyloid-beta") + path(MESH:"Huntington Disease") negativeCorrelation bp(GO:"adenosine catabolic process") - pmid:18930136 + pubmed:30012004 - deg(p(HGNC:APP)) association a(CHEBI:"amyloid-beta") + path(MESH:"Huntington Disease") negativeCorrelation a(MESH:"Gray Matter") - pmid:21214928 + pubmed:30012004 - p(HGNC:APP) association bp(GO:"signal transduction") + path(MESH:"Huntington Disease") negativeCorrelation a(MESH:"White Matter") - pmid:21214928 + pubmed:30012004 - p(HGNC:APP) association bp(GO:"calcium ion homeostasis") + path(MESH:"Huntington Disease") negativeCorrelation bp(GO:"motor behavior") - pmid:21214928 + pubmed:29687724 - p(HGNC:APP) association bp(GO:"protein transport") + path(MESH:"Huntington Disease") decreases bp(GO:"motor behavior") - pmid:21214928 + pubmed:30012004 - p(HGNC:APP) regulates bp(GO:"protein transport") + path(MESH:"Huntington Disease") negativeCorrelation bp(GO:memory) - pmid:21214928 + pubmed:30012004 - p(HGNC:APP) association p(HGNC:ITGB1) + path(MESH:"Huntington Disease") negativeCorrelation bp(GO:"psychomotor behavior") - pmid:21214928 + pubmed:30012004 - p(HGNC:APP) association bp(GO:"anterograde axonal protein transport") + path(MESH:"Huntington Disease") negativeCorrelation bp(GO:"sensory perception") - - - + + + pubmed:30012004 + + path(MESH:"Huntington Disease") negativeCorrelation bp(GO:"visual learning") + - pmid:22122372 + pubmed:29687724 - p(HGNC:APP) increases a(MESH:"Amyloid beta-Peptides") + path(MESH:"Huntington Disease") association path(MESH:Cognition) - pmid:29758300 + pubmed:29687724 - p(HGNC:APP) increases a(MESH:"Amyloid beta-Peptides") + path(MESH:"Huntington Disease") decreases bp(GO:behavior) - pmid:14556719 + pubmed:29687724 - p(HGNC:APP) increases a(MESH:"Amyloid beta-Peptides") + path(MESH:"Huntington Disease") association path(MESH:Dystonia) - pmid:22122372 + pubmed:29687724 - p(HGNC:APP) association a(HBP:HBP00078) + path(MESH:"Huntington Disease") association path(MESH:"Neural Pathways") - pmid:22122372 + pubmed:29687724 - p(HGNC:APP) association a(HBP:HBP00079) + path(MESH:"Huntington Disease") association a(CHEBI:dopamine) - + + + pubmed:30027901 + + path(MESH:"Huntington Disease") increases a(CHEBI:dopamine) + - pmid:22122372 + pubmed:29687724 - p(HGNC:APP) association a(MESH:"Receptors, Cell Surface") + path(MESH:"Huntington Disease") association path(MESH:Depression) - - - + + + pubmed:30027901 + + path(MESH:"Huntington Disease") increases path(MESH:Depression) + - pmid:12428809 + pubmed:30027901 - p(HGNC:APP) association bp(GO:"axonal transport") + path(MESH:"Huntington Disease") increases path(MESH:Depression) - pmid:12428809 + pubmed:30027901 - sec(p(HGNC:APP)) association bp(GO:"regulation of neuronal synaptic plasticity") + path(MESH:"Huntington Disease") increases path(MESH:Depression) - pmid:12428809 + pubmed:29687724 - sec(p(HGNC:APP)) association bp(GO:"negative regulation of neuron apoptotic process") + path(MESH:"Huntington Disease") association path(MESH:"Motor Disorders") - - - pmid:22908190 + pubmed:29687724 - p(HGNC:APP) positiveCorrelation p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") + path(MESH:"Huntington Disease") association path(MESH:"Schizophrenia, Disorganized") - pmid:22908190 + pubmed:29687724 - p(HGNC:APP) positiveCorrelation bp(GO:endocytosis) + path(MESH:"Huntington Disease") association path(MESH:"Cognitive Dysfunction") - pmid:22908190 + pubmed:29687724 - p(HGNC:APP) increases a(GO:endosome) + path(MESH:"Huntington Disease") association a(CHEBI:amantadine) - pmid:22908190 + pubmed:29687724 - p(HGNC:APP) association a(GO:autophagosome) + path(MESH:"Huntington Disease") association a(PUBCHEM:9795739) - - - pmid:26631930 + pubmed:27013968 - surf(p(HGNC:APP)) increases complex(p(HGNC:APP), p(HGNC:SLC40A1)) + path(MESH:"Huntington Disease") increases path(HP:"Autosomal dominant inheritance") - - - - - - - - - - - - - pmid:30663117 + pubmed:30027901 - complex(g(HGNC:"MIR153-1"), r(HGNC:BACE1)) decreases p(HGNC:APP) + path(MESH:"Huntington Disease") increases path(HP:"Autosomal dominant inheritance") - pmid:30663117 + pubmed:30027901 - g(HGNC:"MIR153-1") decreases p(HGNC:APP) + path(MESH:"Huntington Disease") increases path(HP:"Autosomal dominant inheritance") - pmid:30663117 + pubmed:27013968 - g(HGNC:"MIR153-1") decreases a(CHEBI:"amyloid-beta") + path(MESH:"Huntington Disease") increases path(MESH:Hyperkinesis) - pmid:30663117 + pubmed:27013968 - g(HGNC:"MIR153-1") association path(MESH:"Alzheimer Disease") + path(MESH:"Huntington Disease") increases path(HP:"Behavioral abnormality") - pmid:30663117 + pubmed:30027901 - g(HGNC:"MIR153-1") regulates p(HGNC:SNCA) + path(MESH:"Huntington Disease") increases path(HP:"Behavioral abnormality") - pmid:30663117 + pubmed:30027901 - g(HGNC:"MIR153-1") regulates p(HGNC:SNCA) + path(MESH:"Huntington Disease") increases path(HP:"Behavioral abnormality") - pmid:30663117 + pubmed:27013968 - g(HGNC:"MIR153-1") decreases path(MESH:"Parkinson Disease") + path(MESH:"Huntington Disease") association p(HGNC:HTT, pmod(HBP:"CAG repeats")) - pmid:30663117 + pubmed:27013968 - p(HGNC:RANBP9) increases p(HGNC:APP) + path(MESH:"Huntington Disease") decreases p(HGNC:BDNF) - pmid:30663117 + pubmed:27013968 - g(HGNC:"MIR101-1") decreases p(HGNC:APP) + path(MESH:"Huntington Disease") causesNoChange p(HGNC:BDNF) - pmid:30663117 + pubmed:27013968 - g(HGNC:"MIR101-1") decreases act(p(HGNC:APP)) + path(MESH:"Huntington Disease") decreases act(p(HGNC:BDNF)) - pmid:30663117 + pubmed:27013968 - g(HGNC:"MIR101-1") decreases act(p(HGNC:RANBP9)) + path(MESH:"Huntington Disease") causesNoChange p(HGNC:BDNF) - pmid:30663117 + pubmed:30027901 - g(HGNC:"MIR101-1") association path(MESH:"Alzheimer Disease") + path(MESH:"Huntington Disease") decreases p(HGNC:BDNF) - pmid:30663117 + pubmed:27013968 - g(HGNC:"MIR101-1") decreases path(MESH:"Alzheimer Disease") + path(MESH:"Huntington Disease") decreases p(HGNC:NTRK2) - pmid:30663117 + pubmed:27013968 - act(p(HGNC:CAMKK2), ma(kin)) increases p(HGNC:MAPT, pmod(Ph)) + path(MESH:"Huntington Disease") decreases act(p(HGNC:NTRK2)) - pmid:30663117 + pubmed:27013968 - act(p(HGNC:CAMKK2), ma(kin)) increases p(HGNC:MAPT, pmod(Ph)) + path(MESH:"Huntington Disease") causesNoChange p(HGNC:NTRK2) - pmid:30663117 + pubmed:27013968 - p(HGNC:CAMKK2) increases act(a(CHEBI:"amyloid-beta")) + path(MESH:"Huntington Disease") causesNoChange p(HGNC:NTRK2) - pmid:30116051 + pubmed:27013968 - p(HGNC:CAMKK2) increases act(p(HGNC:PSMC5)) + path(MESH:"Huntington Disease") decreases act(p(HGNC:NTRK2)) - pmid:30663117 + pubmed:27013968 - p(HGNC:MAPT, pmod(Ph)) increases a(GO:"neurofibrillary tangle") + path(MESH:"Huntington Disease") decreases p(HGNC:NTRK2, pmod(go:0006468 ! "protein phosphorylation")) - pmid:21214928 + pubmed:27013968 - p(HGNC:MAPT, pmod(Ph)) increases a(GO:"neurofibrillary tangle") + path(MESH:"Huntington Disease") decreases p(HGNC:NTRK2, pmod(go:0006468 ! "protein phosphorylation")) - pmid:28420982 + pubmed:27013968 - p(HGNC:MAPT, pmod(Ph)) increases a(GO:"neurofibrillary tangle") + path(MESH:"Huntington Disease") decreases bp(GO:"ERK1 and ERK2 cascade") - pmid:22122372 + pubmed:27013968 - p(HGNC:MAPT, pmod(Ph)) association bp(GO:"neurofibrillary tangle assembly") + path(MESH:"Huntington Disease") decreases bp(GO:"ERK1 and ERK2 cascade") - pmid:19293145 + pubmed:27013968 - p(HGNC:MAPT, pmod(Ph)) association p(HGNC:FYN) + path(MESH:"Huntington Disease") causesNoChange a(MESH:Neurons) - pmid:24653673 + pubmed:27013968 - p(HGNC:MAPT, pmod(Ph)) association p(FPLX:PPP2, pmod(Me, Tyr, 307)) + path(MESH:"Huntington Disease") decreases p(PFAM:DARPP-32) - pmid:24653673 + pubmed:27013968 - p(HGNC:MAPT, pmod(Ph)) decreases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:MAPT)) + path(MESH:"Huntington Disease") causesNoChange bp(GO:"maintenance of cell number") - pmid:24653673 + pubmed:27013968 - p(HGNC:MAPT, pmod(Ph)) positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:"Huntington Disease") causesNoChange bp(GO:"maintenance of cell number") - pmid:29758300 + pubmed:27013968 - p(HGNC:MAPT, pmod(Ph)) increases path(MESH:"Alzheimer Disease") + path(MESH:"Huntington Disease") causesNoChange p(HGNC:MAPK3) - pmid:8282104 + pubmed:27013968 - p(HGNC:MAPT, pmod(Ph)) positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:"Huntington Disease") causesNoChange p(HGNC:MAPK1) - pmid:29191965 + pubmed:27013968 - p(HGNC:MAPT, pmod(Ph)) positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:"Huntington Disease") causesNoChange p(HGNC:MAPK3, pmod(go:0006468 ! "protein phosphorylation")) - pmid:29191965 + pubmed:27013968 - p(HGNC:MAPT, pmod(Ph)) positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:"Huntington Disease") causesNoChange p(HGNC:MAPK1, pmod(go:0006468 ! "protein phosphorylation")) - pmid:29311797 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) association path(MESH:"Alzheimer Disease") + path(MESH:"Huntington Disease") decreases path(MESH:"Motor Activity") - pmid:26458742 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:"Huntington Disease") decreases path(MESH:"Motor Activity") - pmid:26631930 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:"Huntington Disease") decreases path(MESH:"Motor Activity") - pmid:26631930 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:"Huntington Disease") decreases bp(GO:cognition) - pmid:24653673 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) positiveCorrelation a(CHEBI:homocysteine) + path(MESH:"Huntington Disease") decreases bp(GO:cognition) - pmid:24653673 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) negativeCorrelation p(FPLX:PPP2, pmod(Me)) + path(MESH:"Huntington Disease") increases path(HP:Dyskinesia) - pmid:29758300 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) decreases act(complex(GO:"proteasome complex")) + path(MESH:"Huntington Disease") increases path(DOID:dystonia) - pmid:29758300 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) association complex(GO:"proteasome complex") + path(MESH:"Huntington Disease") increases path(DOID:dystonia) - pmid:29758300 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) association bp(GO:autophagy) + path(MESH:"Huntington Disease") increases path(DOID:dystonia) - pmid:29758300 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) positiveCorrelation p(HGNC:MTOR) + path(MESH:"Huntington Disease") increases path(MESH:Anxiety) - pmid:29758300 + pubmed:30027901 - deg(p(HGNC:MAPT, pmod(Ph))) decreases bp(GO:"neuron death") + path(MESH:"Huntington Disease") increases path(DOID:"sleep disorder") - pmid:29758300 + pubmed:30027901 - deg(p(HGNC:MAPT, pmod(Ph))) decreases path(HBP:neuroinflammation) + path(MESH:"Huntington Disease") increases path(HP:"Cognitive impairment") - pmid:29758300 + pubmed:30027901 - deg(p(HGNC:MAPT, pmod(Ph))) increases bp(GO:cognition) + path(MESH:"Huntington Disease") increases path(HP:"Cognitive impairment") - pmid:29758300 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) positiveCorrelation p(HGNC:TREM2) + path(MESH:"Huntington Disease") increases path(HP:"Cognitive impairment") - pmid:29758300 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) positiveCorrelation p(HGNC:MAPT, var("p.Ala152Thr")) + path(MESH:"Huntington Disease") increases path(MESH:Neuropathology) - pmid:24027553 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) association path(MESH:"Neurofibrillary Tangles") + path(MESH:"Huntington Disease") increases path(HP:"Atrophy/Degeneration involving the caudate nucleus") - pmid:24027553 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) decreases act(a(CHEBI:Thrombin)) + path(MESH:"Huntington Disease") increases path(HP:"Atrophy/Degeneration involving the caudate nucleus") - pmid:17403556 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) positiveCorrelation path(HBP:Neurodegeneration) + path(MESH:"Huntington Disease") increases path(HP:"Abnormal putamen morphology") - pmid:22611162 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) positiveCorrelation p(HGNC:MAPT, var("p.Lys280del")) + path(MESH:"Huntington Disease") increases path(HP:"Abnormal putamen morphology") - pmid:24760868 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) association act(p(HGNC:MAPT)) + path(MESH:"Huntington Disease") increases path(HP:"Abnormal putamen morphology") - pmid:26195256 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) decreases deg(p(HGNC:MAPT)) + path(MESH:"Huntington Disease") increases path(MESH:"Suicidal Ideation") - pmid:21882945 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) regulates complex(a(GO:microtubule), p(HGNC:MAPT)) + path(MESH:"Huntington Disease") increases path(MESH:"Suicidal Ideation") - pmid:21882945 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + path(MESH:"Huntington Disease") association path(MESH:"Westphal disease") - pmid:30985105 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + path(MESH:"Huntington Disease") increases path(HP:Bradykinesia) - pmid:26631930 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + path(MESH:"Huntington Disease") increases path(HP:"Oculomotor apraxia") - pmid:21882945 + pubmed:30027901 - deg(p(HGNC:MAPT, pmod(Ph))) association p(HGNC:BAG2) + path(MESH:"Huntington Disease") increases path(MESH:"Cognitive Dissonance") - pmid:22419736 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) negativeCorrelation act(p(FPLX:AMPK)) + path(MESH:"Huntington Disease") decreases bp(GO:"learning or memory") - pmid:22419736 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) negativeCorrelation p(FPLX:AMPK) + path(MESH:"Huntington Disease") increases path(MESH:Apathy) - pmid:22419736 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) association path(MESH:"Retinal Degeneration") + path(MESH:"Huntington Disease") increases path(HP:Irritability) - pmid:29191965 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) positiveCorrelation a(HBP:"Tau aggregates") + path(MESH:"Huntington Disease") increases path(HP:"Abnormality of the cerebral subcortex") - pmid:26631930 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) increases a(HBP:"Tau aggregates") + path(MESH:"Huntington Disease") increases path(HP:"Sleep disturbance") - pmid:26631930 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) increases a(HBP:"Tau aggregates") + path(MESH:"Huntington Disease") decreases a(MESH:Neostriatum) - pmid:22817713 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) increases a(HBP:"Tau aggregates") + path(MESH:"Huntington Disease") increases path(HP:"Cerebral white matter atrophy") - pmid:28420982 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) increases a(HBP:"Tau oligomers") + path(MESH:"Huntington Disease") increases path(HP:"Neuronal loss in the cerebral cortex") - pmid:28420982 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) increases a(HBP:"Tau oligomers") + path(MESH:"Huntington Disease") increases path(HP:"Cerebellar atrophy") - pmid:26631930 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) decreases complex(a(MESH:Actins), p(HGNC:MAPT)) + path(MESH:"Huntington Disease") decreases a(CHEBI:"gamma-aminobutyric acid") - pmid:27260836 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) partOf complex(GO:"neurofibrillary tangle") + path(MESH:"Huntington Disease") decreases a(CHEBI:"gamma-aminobutyric acid") - pmid:27260836 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) partOf complex(GO:"neurofibrillary tangle") + path(MESH:"Huntington Disease") decreases p(HGNC:GAD1) - pmid:27260836 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) association p(HGNC:PICALM) + path(MESH:"Huntington Disease") decreases p(HGNC:GAD1) - pmid:27260836 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) association p(HGNC:PICALM) + path(MESH:"Huntington Disease") decreases complex(GO:"GABA receptor complex") - pmid:27260836 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) partOf complex(GO:"Pick body") + path(MESH:"Huntington Disease") causesNoChange complex(GO:"GABA receptor complex") - pmid:27260836 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) partOf complex(GO:"Cajal body") + path(MESH:"Huntington Disease") causesNoChange p(HGNC:TH) - pmid:18467332 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) decreases complex(p(HGNC:MAPT), p(HGNC:SRC)) + path(MESH:"Huntington Disease") decreases r(HGNC:SLC18A2) - pmid:18467332 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) decreases complex(p(HGNC:MAPT), p(HGNC:PLCG1)) + path(MESH:"Huntington Disease") decreases r(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") - pmid:18467332 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) decreases complex(p(HGNC:GRB2), p(HGNC:MAPT)) + path(MESH:"Huntington Disease") decreases p(HGNC:SLC18A3) - pmid:18467332 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) decreases complex(p(HGNC:MAPT), p(HGNC:PIK3R1)) + path(MESH:"Huntington Disease") increases a(CHEBI:serotonin) - pmid:10464280 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) negativeCorrelation rxn(reactants(p(HGNC:MAPT, pmod(Ph))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT))) + path(MESH:"Huntington Disease") increases a(MESH:"Hydroxyindoleacetic Acid") - pmid:19363271 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) positiveCorrelation p(FPLX:HSP90) + path(MESH:"Huntington Disease") decreases p(HGNC:CTH) - pmid:14963027 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) association p(HGNC:HSPB1) + path(MESH:"Huntington Disease") decreases p(MGI:Cth) - pmid:14963027 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) increases complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) + path(MESH:"Huntington Disease") increases a(GO:autophagosome) - pmid:14963027 + pubmed:30027901 - act(p(HGNC:MAPT, pmod(Ph))) increases bp(GO:"neuron apoptotic process") + path(MESH:"Huntington Disease") increases path(MESH:"Protein Aggregation, Pathological") - pmid:14612456 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) positiveCorrelation p(HGNC:MAPT, pmod(Ub)) + path(MESH:"Huntington Disease") increases r(HGNC:MAP1LC3A) - pmid:14612456 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) isA complex(p(HGNC:MAPT, pmod(Ph)), p(HGNC:STUB1), p(HGNC:UBE2D2)) + path(MESH:"Huntington Disease") increases r(HGNC:ULK2) - pmid:17954934 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) negativeCorrelation p(HGNC:BAG1) + path(MESH:"Huntington Disease") increases r(HGNC:LAMP2) - pmid:23943618 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) negativeCorrelation complex(p(FPLX:PPP2), p(HGNC:MAPT)) + path(MESH:"Huntington Disease") decreases r(HGNC:PINK1) - pmid:16630055 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) negativeCorrelation p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) + path(MESH:"Huntington Disease") decreases r(HGNC:WDFY3) - pmid:20869593 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) positiveCorrelation p(HGNC:MAPT, pmod(Ac)) + path(MESH:"Huntington Disease") decreases r(HGNC:FKBP1A) - pmid:19401603 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph)) positiveCorrelation complex(a(MESH:Microtubules), p(HGNC:MAPT, pmod(Ph))) + path(MESH:"Huntington Disease") increases bp(GO:"mitochondrial fragmentation involved in apoptotic process") - - - pmid:24760868 + pubmed:30027901 - act(p(HGNC:MAPT)) association p(HGNC:MAPT, pmod(Ph)) + path(MESH:"Huntington Disease") decreases composite(a(MESH:Autophagosomes), a(MESH:Mitochondria)) - - - - - pmid:26195256 + pubmed:30027901 - p(HGNC:MAPT, loc(MESH:"Neurofibrillary Tangles")) positiveCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation), loc(MESH:"Cerebrospinal Fluid")) + path(MESH:"Huntington Disease") decreases bp(GO:"mRNA transcription") - pmid:19293145 + pubmed:30027901 - p(HGNC:MAPT) association a(MESH:"Neurofibrillary Tangles") + path(MESH:"Huntington Disease") increases bp(GO:"cytokine production involved in inflammatory response") - pmid:14556719 + pubmed:30027901 - p(HGNC:MAPT) association a(MESH:"Neurofibrillary Tangles") + path(MESH:"Huntington Disease") increases path(HP:"Increased inflammatory response") - pmid:14556719 + pubmed:30027901 - deg(p(HGNC:MAPT)) increases a(MESH:"Neurofibrillary Tangles") + path(MESH:"Huntington Disease") increases bp(GO:"neuroinflammatory response") - pmid:27574109 + pubmed:30027901 - p(HGNC:MAPT) association a(MESH:"Neurofibrillary Tangles") + path(MESH:"Huntington Disease") increases p(OMIT:0006999) - - - pmid:26813123 + pubmed:30027901 - act(p(HGNC:MAPT)) association act(p(HGNC:CHRM1)) + path(MESH:"Huntington Disease") association p(HGNCGENEFAMILY:"NF-kappa B complex subunits") - - - pmid:24590577 + pubmed:30027901 - p(HGNC:MAPT) regulates bp(GO:"microtubule anchoring") + path(MESH:"Huntington Disease") association bp(GO:"oxidative phosphorylation") - pmid:24590577 + pubmed:30027901 - p(HGNC:MAPT) regulates bp(GO:"axonal transport") + path(MESH:"Huntington Disease") increases path(NCIT:C19375) - pmid:12428809 + pubmed:30027901 - p(HGNC:MAPT) association bp(GO:"axonal transport") + path(MESH:"Huntington Disease") increases bp(GO:"regulation of cell cycle") - pmid:12428809 + pubmed:30027901 - p(HGNC:MAPT) increases bp(GO:"axonal transport") + path(MESH:"Huntington Disease") increases path(MESH:"Movement Disorders") - pmid:21734277 + pubmed:30027901 - tloc(p(HGNC:MAPT)) causesNoChange bp(GO:"axonal transport") + path(MESH:"Huntington Disease") increases path(HP:Parkinsonism) - pmid:28420982 + pubmed:30027901 - p(HGNC:MAPT) regulates bp(GO:"axonal transport") + path(MESH:"Huntington Disease") increases path(HP:Agitation) - pmid:26631930 + pubmed:30027901 - p(HGNC:MAPT) regulates bp(GO:"axonal transport") + path(MESH:"Huntington Disease") decreases bp(GO:"energy homeostasis") - pmid:25514383 + pubmed:30027901 - p(HGNC:MAPT) positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:"Huntington Disease") association tloc(a(CHEBI:"D-glutamate residue"), fromLoc(GO:cytoplasm), toLoc(GO:"extracellular space")) - pmid:29758300 + pubmed:25437566 - p(HGNC:MAPT) association path(MESH:"Alzheimer Disease") + path(MESH:"Huntington Disease") decreases p(HGNC:HSP90AB1) - pmid:14556719 + pubmed:25437566 - p(HGNC:MAPT) association path(MESH:"Alzheimer Disease") + path(MESH:"Huntington Disease") decreases p(HGNC:HSPA8) - pmid:24027553 + pubmed:25437566 - p(HGNC:MAPT) association path(MESH:"Alzheimer Disease") + path(MESH:"Huntington Disease") decreases p(HGNC:HSPA14) - pmid:24027553 + pubmed:25437566 - p(HGNC:MAPT) positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:"Huntington Disease") decreases p(HGNC:TCP1) - pmid:27574109 + pubmed:14556719 - p(HGNC:MAPT) positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:"Huntington Disease") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) - pmid:27574109 + pubmed:14556719 - p(HGNC:MAPT) positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:"Huntington Disease") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) - pmid:30126037 + pubmed:22908190 - p(HGNC:MAPT) association path(MESH:"Alzheimer Disease") + path(MESH:"Huntington Disease") positiveCorrelation p(CONSO:"UBB+1") - pmid:28420982 + pubmed:25784053 - p(HGNC:MAPT) positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:"Huntington Disease") positiveCorrelation p(FPLX:HSPA) - pmid:28420982 + pubmed:25784053 - p(HGNC:MAPT) positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:"Huntington Disease") negativeCorrelation p(HGNC:ATF6) - pmid:26631930 + pubmed:18930136 - p(HGNC:MAPT) positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:"Huntington Disease") increases p(HGNC:CTSD) - pmid:29238289 + pubmed:18930136 - p(HGNC:MAPT) biomarkerFor path(MESH:"Alzheimer Disease") + path(MESH:"Huntington Disease") positiveCorrelation a(GO:autolysosome) - pmid:29980653 + pubmed:29024336 - p(HGNC:MAPT) positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:"Huntington Disease") increases path(MESH:"Proteostasis Deficiencies") - - - - - - - - - - - - - pmid:26837465 + pubmed:29311797 - p(HGNC:MAPT) decreases act(p(HGNC:ESR1), ma(tscript)) + path(MESH:"Huntington Disease") association p(HGNC:STUB1) - - - - - - - pmid:10391244 + pubmed:30837838 - act(p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 231)) + path(MESH:"Huntington Disease") association p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation"), loc(GO:"inclusion body")) - - - - - pmid:19277525 + pubmed:30837838 - p(HGNC:MAPT) increases complex(p(HGNC:MAPT), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + path(MESH:"Huntington Disease") association p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination"), loc(GO:"inclusion body")) - pmid:12428809 + pubmed:30046111 - p(HGNC:MAPT) increases bp(GO:"microtubule cytoskeleton organization") + path(MESH:"Parkinson Disease") association act(a(MESH:"Lymphatic Vessels")) - pmid:12428809 + pubmed:30663117 - p(HGNC:MAPT) decreases bp(GO:"microtubule depolymerization") + path(MESH:"Parkinson Disease") association a(CONSO:"alpha-synuclein aggregates") - pmid:12428809 + pubmed:30663117 - p(HGNC:MAPT) increases bp(GO:"axon development") + path(MESH:"Parkinson Disease") association p(HGNC:SNCA, pmod(CONSO:misfolded)) - + + + pubmed:30663117 + + path(MESH:"Parkinson Disease") association g(HGNC:MIR132) + - + + + pubmed:30663117 + + path(MESH:"Parkinson Disease") association g(NCBIGENE:406950) + - + + + pubmed:30663117 + + path(MESH:"Parkinson Disease") association p(HGNC:LRRK2) + - + + + pubmed:30688256 + + path(MESH:"Parkinson Disease") association p(HGNC:LRRK2) + - pmid:29758300 + pubmed:24113872 - p(HGNC:MAPT) increases complex(a(GO:cytoskeleton), a(GO:microtubule)) + path(MESH:"Parkinson Disease") positiveCorrelation p(HGNC:LRRK2) - pmid:29758300 + pubmed:30663117 - p(HGNC:MAPT) increases bp(GO:"anterograde axonal protein transport") + path(MESH:"Parkinson Disease") decreases g(HGNC:MIR205) - pmid:27373205 + pubmed:30663117 - p(HGNC:MAPT) causesNoChange bp(GO:"anterograde axonal protein transport") + path(MESH:"Parkinson Disease") decreases p(HGNC:PARK7) - pmid:29758300 + pubmed:30562574 - p(HGNC:MAPT) increases bp(GO:"retrograde axonal protein transport") + path(MESH:"Parkinson Disease") association p(HGNC:PARK7) - pmid:27373205 + pubmed:30663117 - p(HGNC:MAPT) causesNoChange bp(GO:"retrograde axonal protein transport") + path(MESH:"Parkinson Disease") increases g(HGNC:MIR494) - pmid:29758300 + pubmed:30663117 - p(HGNC:MAPT) association path(MESH:Tauopathies) + path(MESH:"Parkinson Disease") decreases g(HGNC:MIR34B) - pmid:29980653 + pubmed:30663117 - p(HGNC:MAPT) positiveCorrelation path(MESH:Tauopathies) + path(MESH:"Parkinson Disease") decreases g(HGNC:MIR34C) - pmid:29758300 + pubmed:20869593 - p(HGNC:MAPT) association path(MESH:"Frontotemporal Dementia") + path(MESH:"Parkinson Disease") association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:28420982 + pubmed:19126755 - p(HGNC:MAPT) positiveCorrelation path(MESH:"Frontotemporal Dementia") + path(MESH:"Parkinson Disease") association p(CONSO:"alpha-6 alpha-4 beta-2 beta-3 nAChR", loc(MESH:"Basal Ganglia")) - pmid:29758300 + pubmed:19126755 - p(HGNC:MAPT) association path(MESH:"Niemann-Pick Diseases") + path(MESH:"Parkinson Disease") positiveCorrelation path(MESH:Tremor) - pmid:29758300 + pubmed:19126755 - p(HGNC:MAPT) association path(MESH:"Supranuclear Palsy, Progressive") + path(MESH:"Parkinson Disease") positiveCorrelation path(MESH:Hypokinesia) - pmid:30126037 + pubmed:19126755 - p(HGNC:MAPT) association path(MESH:"Supranuclear Palsy, Progressive") + path(MESH:"Parkinson Disease") positiveCorrelation path(MESH:"Muscle Rigidity") - pmid:29758300 + pubmed:19126755 - p(HGNC:MAPT) association p(HGNC:NBR1) + path(MESH:"Parkinson Disease") negativeCorrelation path(MESH:"Tobacco Use Disorder") - pmid:29758300 + pubmed:17009926 - p(HGNC:MAPT) positiveCorrelation p(HGNC:TREM2) + path(MESH:"Parkinson Disease") negativeCorrelation act(p(FPLX:CHRN)) - + + + pubmed:17009926 + + path(MESH:"Parkinson Disease") negativeCorrelation p(FPLX:CHRN) + - pmid:14556719 + pubmed:11230871 - p(HGNC:MAPT) association a(GO:microtubule) + path(MESH:"Parkinson Disease") association p(FPLX:CHRN) - pmid:25374103 + pubmed:26813123 - p(HGNC:MAPT) regulates act(a(GO:microtubule)) + path(MESH:"Parkinson Disease") negativeCorrelation a(MESH:"Cholinergic Neurons") - pmid:28420982 + pubmed:24590577 - p(HGNC:MAPT) increases a(GO:microtubule) + path(MESH:"Parkinson Disease") association p(HGNC:CHRM4) - pmid:26631930 + pubmed:24590577 - tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) negativeCorrelation a(GO:microtubule) + path(MESH:"Parkinson Disease") decreases act(a(MESH:"Dopaminergic Neurons")) - pmid:29626319 + pubmed:21722302 - p(HGNC:MAPT) increases a(GO:microtubule) + path(MESH:"Parkinson Disease") decreases a(MESH:"Dopaminergic Neurons") - pmid:22908190 + pubmed:24762290 - p(HGNC:MAPT) association a(HBP:"paired helical filaments") + path(MESH:"Parkinson Disease") decreases path(MESH:Memory) - pmid:22908190 + pubmed:24762290 - p(HGNC:MAPT) association a(HBP:"paired helical filaments") + path(MESH:"Parkinson Disease") association path(MESH:Memory) - pmid:22908190 + pubmed:24762290 - p(HGNC:MAPT) association a(GO:"Lewy body") + path(MESH:"Parkinson Disease") association complex(CONSO:"alpha-4 beta-2 nAChR") - pmid:22908190 + pubmed:28901280 - p(HGNC:MAPT) association a(GO:"Pick body") + path(MESH:"Parkinson Disease") association p(MESH:"Receptors, Nicotinic") - pmid:27574109 + pubmed:22020111 - p(HGNC:MAPT) association a(GO:"Pick body") + path(MESH:"Parkinson Disease") positiveCorrelation a(CONSO:"protein aggregates") - pmid:22908190 + pubmed:30688256 - p(HGNC:MAPT) negativeCorrelation act(complex(GO:"proteasome complex")) + path(MESH:"Parkinson Disease") association p(HGNC:PRKN) - pmid:26751493 + pubmed:21722302 - p(HGNC:MAPT) negativeCorrelation act(complex(GO:"proteasome complex")) + path(MESH:"Parkinson Disease") association p(HGNC:PRKN) - - - pmid:22908190 + pubmed:14556719 - deg(p(HGNC:MAPT)) increases p(HGNC:MAPT, frag("?")) + path(MESH:"Parkinson Disease") positiveCorrelation p(HGNC:PRKN) - pmid:30145931 + pubmed:22908190 - p(HGNC:MAPT) increases p(HGNC:SQSTM1) + path(MESH:"Parkinson Disease") positiveCorrelation p(HGNC:PRKN) - - - pmid:30145931 + pubmed:27181519 - p(HGNC:MAPT, loc(MESH:Dendrites)) decreases a(MESH:"Dendritic Spines") + path(MESH:"Parkinson Disease") association p(HGNC:PRKN) - - - pmid:30116051 + pubmed:30688256 - p(HGNC:MAPT) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + path(MESH:"Parkinson Disease") association p(HGNC:PINK1) - pmid:23528736 + pubmed:21722302 - deg(p(HGNC:MAPT)) association bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + path(MESH:"Parkinson Disease") association path(CONSO:Neurodegeneration) - pmid:29215007 + pubmed:21722302 - p(HGNC:MAPT) increases bp(GO:"actin filament bundle assembly") + path(MESH:"Parkinson Disease") association bp(CONSO:"protein aggregation") - pmid:29215007 + pubmed:21722302 - p(HGNC:MAPT) increases bp(GO:"actin filament bundle assembly") + path(MESH:"Parkinson Disease") association bp(GO:"parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization") - + + + pubmed:21722302 + + path(MESH:"Parkinson Disease") association p(HGNC:PARK7, var("?")) + - + + + pubmed:21722302 + + path(MESH:"Parkinson Disease") association a(MESH:Paraquat) + - + + + pubmed:21722302 + + path(MESH:"Parkinson Disease") decreases bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") + - + + + pubmed:21722302 + + path(MESH:"Parkinson Disease") decreases bp(MESH:"Unfolded Protein Response") + - + + + pubmed:21722302 + + path(MESH:"Parkinson Disease") increases bp(GO:"neuron death") + - + + + pubmed:14556719 + + path(MESH:"Parkinson Disease") positiveCorrelation bp(GO:"neuron death") + - + + + pubmed:29758300 + + path(MESH:"Parkinson Disease") association p(HGNC:VPS35, var("?")) + - + + + pubmed:29758300 + + path(MESH:"Parkinson Disease") negativeCorrelation bp(GO:macroautophagy) + - + + + pubmed:14556719 + + path(MESH:"Parkinson Disease") negativeCorrelation bp(GO:"synaptic transmission, dopaminergic") + - + + + pubmed:14556719 + + path(MESH:"Parkinson Disease") negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + - + + + pubmed:14556719 + + path(MESH:"Parkinson Disease") association p(HGNC:UCHL1, var("?")) + - + + + pubmed:14556719 + + path(MESH:"Parkinson Disease") association p(HGNC:UCHL1, var("p.Ile93Met")) + - pmid:24027553 + pubmed:14556719 - p(HGNC:MAPT) negativeCorrelation act(a(MESH:Neurons)) + path(MESH:"Parkinson Disease") association a(MESH:"Lewy Bodies") - pmid:26631930 + pubmed:14556719 - p(HGNC:MAPT) regulates act(a(MESH:Neurons)) + path(MESH:"Parkinson Disease") association p(HGNC:SNCA, var("p.Ala30Pro")) - pmid:26631930 + pubmed:14556719 - p(HGNC:MAPT) increases a(MESH:Neurons) + path(MESH:"Parkinson Disease") association p(HGNC:SNCA, var("p.Ala53Thr")) - pmid:26631930 + pubmed:22908190 - p(HGNC:MAPT) increases act(a(MESH:Neurons)) + path(MESH:"Parkinson Disease") positiveCorrelation p(HGNC:SNCA, pmod(go:0016567 ! "protein ubiquitination")) - pmid:29238289 + pubmed:22908190 - p(HGNC:MAPT, loc(GO:"extracellular region")) increases act(a(MESH:Neurons)) + path(MESH:"Parkinson Disease") association p(HGNC:UCHL1) - pmid:29238289 + pubmed:18930136 - sec(p(HGNC:MAPT)) increases act(a(MESH:Neurons)) + path(MESH:"Parkinson Disease") positiveCorrelation a(GO:autophagosome) - - - + + + pubmed:28803412 + + path(MESH:"Parkinson Disease") association p(HGNC:SNCA) + - + + + pubmed:28803412 + + path(MESH:"Parkinson Disease") positiveCorrelation a(CONSO:CONSO00093) + - + + + pubmed:27075649 + + path(MESH:"Parkinson Disease") positiveCorrelation a(CONSO:CONSO00016) + - + + + pubmed:30116051 + + path(MESH:"Parkinson Disease") association p(HGNC:PINK1, var("?")) + - pmid:27574109 + pubmed:30116051 - p(HGNC:MAPT) association a(HBP:pretangles) + path(MESH:"Parkinson Disease") association p(HGNC:PRKN, var("?")) - pmid:27574109 + pubmed:30116051 - p(HGNC:MAPT) association a(HBP:"Braak_Stage I") + path(MESH:"Parkinson Disease") association p(HGNC:LRRK2, var("?")) - pmid:27574109 + pubmed:29024336 - p(HGNC:MAPT) association a(HBP:"Braak_Stage II") + path(MESH:"Parkinson Disease") increases path(MESH:"Proteostasis Deficiencies") - pmid:27574109 + pubmed:30985105 - p(HGNC:MAPT) association a(HBP:"Corticobasal Degeneration") + path(MESH:"Parkinson Disease") positiveCorrelation deg(a(CONSO:"Dopaminergic cell groups")) - pmid:27574109 + pubmed:30985105 - p(HGNC:MAPT) positiveCorrelation a(HBP:"Corticobasal Degeneration") + path(MESH:"Parkinson Disease") association complex(p(HGNC:SNCA), p(HGNC:SNCA)) - pmid:27574109 + pubmed:30985105 - p(HGNC:MAPT) positiveCorrelation a(HBP:"Corticobasal Degeneration") + path(MESH:"Parkinson Disease") association act(p(HGNCGENEFAMILY:Calpains)) - pmid:27574109 + pubmed:30985105 - p(HGNC:MAPT) positiveCorrelation path(MESH:"Pick Disease of the Brain") + path(MESH:"Parkinson Disease") association act(p(HGNCGENEFAMILY:Calpains)) - pmid:27574109 + pubmed:29311797 - p(HGNC:MAPT) positiveCorrelation path(MESH:"Pick Disease of the Brain") + path(MESH:"Parkinson Disease") association p(HGNC:STUB1) - - - + + + pubmed:26751493 + + path(MESH:"Parkinson Disease") association g(DBSNP:rs2471738) + - + + + pubmed:26751493 + + path(MESH:"Parkinson Disease") association g(DBSNP:rs242557) + - + + + pubmed:26631930 + + path(MESH:"Parkinson Disease") increases a(CHEBI:"iron(0)") + - pmid:29590627 + pubmed:29980653 - p(HGNC:MAPT) increases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + path(MESH:"Parkinson Disease") isA path(MESH:"Neurodegenerative Diseases") - pmid:26195256 + pubmed:29980653 - p(HGNC:MAPT, loc(MESH:"Neurofibrillary Tangles")) positiveCorrelation p(HGNC:MAPT, loc(MESH:"Cerebrospinal Fluid")) + path(MESH:"Parkinson Disease") positiveCorrelation p(HGNC:SNCA, var("?")) - pmid:26195256 + pubmed:29980653 - p(HGNC:MAPT, loc(MESH:"Cerebrospinal Fluid")) positiveCorrelation p(HGNC:MAPT, loc(MESH:"Neurofibrillary Tangles")) + path(MESH:"Parkinson Disease") isA path(MESH:"Lewy Body Disease") - pmid:26631930 + pubmed:30837838 - p(HGNC:MAPT) positiveCorrelation tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) + path(MESH:"Parkinson Disease") association p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation"), loc(GO:"inclusion body")) - pmid:26631930 + pubmed:30837838 - tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) positiveCorrelation p(HGNC:MAPT) + path(MESH:"Parkinson Disease") association p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination"), loc(GO:"inclusion body")) - + + + pubmed:30046111 + + bp(GO:"excitatory chemical synaptic transmission") association act(a(MESH:"Lymphatic Vessels")) + - + + + pubmed:29661268 + + bp(GO:learning) negativeCorrelation p(HGNC:MAPT, var("p.Lys?Gln")) + - pmid:24760868 + pubmed:21673407 - p(HGNC:MAPT) positiveCorrelation bp(GO:"long-term synaptic potentiation") + bp(GO:learning) association p(HGNC:HTR4) - pmid:24760868 + pubmed:19293145 - tloc(p(HGNC:MAPT), fromLoc(GO:"dendritic shaft"), toLoc(GO:synapse)) positiveCorrelation bp(GO:"long-term synaptic potentiation") + bp(GO:learning) association path(MESH:"Alzheimer Disease") - pmid:24760868 + pubmed:24511233 - p(HGNC:MAPT) positiveCorrelation bp(GO:"long-term synaptic potentiation") + bp(GO:learning) association a(MESH:Hippocampus) - pmid:24760868 + pubmed:24511233 - tloc(p(HGNC:MAPT), fromLoc(GO:"dendritic shaft"), toLoc(GO:synapse)) association bp(MESH:"Neuronal Plasticity") + bp(GO:learning) association a(MESH:Hippocampus) - pmid:24760868 + pubmed:24511233 - p(HGNC:MAPT) regulates bp(MESH:"Neuronal Plasticity") + bp(GO:learning) association a(MESH:"Cerebral Cortex") - pmid:24760868 + pubmed:24511233 - p(HGNC:MAPT) increases complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) + bp(GO:learning) association a(MESH:"Cerebral Cortex") - pmid:17187063 + pubmed:24511233 - p(HGNC:MAPT) increases complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) + bp(GO:learning) association bp(GO:"long-term synaptic potentiation") - pmid:24760868 + pubmed:24511233 - p(HGNC:MAPT) increases complex(complex(GO:"actin filament bundle"), p(HGNC:MAPT)) + bp(GO:learning) association a(MESH:"Prefrontal Cortex") - pmid:24760868 + pubmed:17009926 - p(HGNC:MAPT) association complex(GO:"filamentous actin") + bp(GO:learning) association p(FPLX:CHRN) - pmid:17187063 + pubmed:26813123 - p(HGNC:MAPT) directlyIncreases complex(GO:"filamentous actin") + bp(GO:learning) association bp(GO:"synaptic transmission, cholinergic") - pmid:24760868 + pubmed:26813123 - p(HGNC:MAPT, loc(GO:synapse)) increases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) + bp(GO:learning) positiveCorrelation bp(GO:"synaptic transmission, cholinergic") - - - + + + pubmed:21482353 + + bp(GO:learning) association bp(GO:"synaptic transmission, cholinergic") + - pmid:28528849 + pubmed:26813123 - p(HGNC:MAPT) causesNoChange a(GO:synapse) + bp(GO:learning) association a(CHEBI:acetylcholine) - pmid:26631930 + pubmed:24590577 - tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) decreases act(a(GO:synapse)) + bp(GO:learning) association p(HGNC:CHRM1) - pmid:26631930 + pubmed:19721446 - tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) decreases act(a(GO:synapse)) + bp(GO:learning) association p(HGNC:CHRNA7) - pmid:26631930 + pubmed:30106381 - p(HGNC:MAPT) negativeCorrelation act(a(GO:synapse)) + bp(GO:learning) association p(HGNC:ADNP) - - - pmid:25887395 + pubmed:22908190 - p(HGNC:MAPT) causesNoChange tloc(a(HBP:"Tau fibrils"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + bp(GO:learning) association bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:29980653 + pubmed:24355211 - tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) increases a(HBP:"Tau fibrils") + bp(GO:learning) negativeCorrelation p(HGNC:GSK3B) - pmid:24869773 + pubmed:21843595 - p(HGNC:MAPT) association a(HBP:"Tau fibrils") + bp(GO:learning) negativeCorrelation p(MGI:Sumo3) - pmid:25887395 + pubmed:30046111 - p(HGNC:MAPT) causesNoChange a(HBP:"Tau aggregates") + bp(GO:"neuronal signal transduction") association act(a(MESH:"Lymphatic Vessels")) - pmid:25374103 + pubmed:24590577 - tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) increases a(HBP:"Tau aggregates") + bp(GO:"neuronal signal transduction") association p(HGNC:CHRM1) - pmid:28420982 + pubmed:30515821 - sec(p(HGNC:MAPT)) association a(HBP:"Tau aggregates") + bp(MESH:Glycolysis) increases bp(GO:"neuron differentiation") - pmid:27373205 + pubmed:30515821 - p(HGNC:MAPT) increases a(HBP:"Tau aggregates") + bp(MESH:Glycolysis) regulates bp(GO:neurogenesis) - - - pmid:21882945 + pubmed:30935091 - p(HGNC:MAPT) increases complex(a(GO:microtubule), p(HGNC:MAPT)) + bp(GO:"response to oxidative stress") association p(HGNC:HDAC6) - pmid:29191965 + pubmed:22110360 - p(HGNC:MAPT) increases complex(a(GO:microtubule), p(HGNC:MAPT)) + bp(GO:"response to oxidative stress") increases act(p(HGNC:MAP3K5)) - pmid:26631930 + pubmed:23092889 - p(HGNC:MAPT) directlyIncreases complex(a(GO:microtubule), p(HGNC:MAPT)) + bp(GO:"response to oxidative stress") increases act(complex(GO:"inflammasome complex")) - pmid:21882945 + pubmed:24189435 - deg(p(HGNC:MAPT)) negativeCorrelation bp(GO:aging) + bp(GO:"response to oxidative stress") association bp(GO:"mitochondrial electron transport, cytochrome c to oxygen") - pmid:21882945 + pubmed:23533697 - p(HGNC:MAPT) increases path(HBP:neurotoxicity) + bp(GO:"response to oxidative stress") decreases a(NIFT:"Cerebral blood flow") - pmid:21882945 + pubmed:30515821 - deg(p(HGNC:MAPT)) negativeCorrelation p(HGNC:AKT1) + bp(GO:"response to oxidative stress") increases act(p(HGNC:DNM1)) - pmid:30126037 + pubmed:11230871 - p(HGNC:MAPT) association path(MESH:"Brain Injuries, Traumatic") + bp(GO:"response to oxidative stress") negativeCorrelation p(FPLX:CHRN) - + + + pubmed:23516100 + + bp(GO:"response to oxidative stress") increases tloc(p(HGNC:SNCA), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) + - + + + pubmed:23516100 + + bp(GO:"response to oxidative stress") increases act(p(HGNCGENEFAMILY:Caspases)) + - pmid:22419736 + pubmed:27299292 - p(HGNC:MAPT) increases path(MESH:"Retinal Degeneration") + bp(GO:"response to oxidative stress") increases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) - pmid:29191965 + pubmed:14556719 - p(HGNC:MAPT) increases complex(p(HGNC:MAPT), p(HGNC:TUBA1A)) + bp(GO:"response to oxidative stress") increases p(HGNC:SOD1, pmod(go:0016567 ! "protein ubiquitination"), var("?")) - pmid:29191965 + pubmed:14556719 - p(HGNC:MAPT) increases complex(p(HGNC:MAPT), p(HGNC:TUBB)) + bp(GO:"response to oxidative stress") increases p(HGNC:SOD1, pmod(CONSO:misfolding), var("?")) - pmid:29191965 + pubmed:23746257 - p(HGNC:MAPT) association a(GO:"cell body") + bp(GO:"response to oxidative stress") increases a(MESH:"Heat-Shock Proteins") - - - + + + pubmed:23746257 + + bp(GO:"response to oxidative stress") association bp(CONSO:Proteostasis) + - pmid:25374103 + pubmed:18930136 - p(HGNC:MAPT) decreases bp(GO:"anterograde axonal transport") + bp(GO:"response to oxidative stress") increases p(HGNC:SQSTM1) - pmid:26631930 + pubmed:18930136 - p(HGNC:MAPT) decreases bp(GO:"anterograde axonal transport") + bp(GO:"response to oxidative stress") increases r(HGNC:SQSTM1) - pmid:28420982 + pubmed:24563850 - p(HGNC:MAPT) regulates bp(GO:"generation of neurons") + bp(GO:"response to oxidative stress") decreases act(p(HGNC:KEAP1)) - pmid:28420982 + pubmed:24563850 - p(HGNC:MAPT) increases bp(HP:Neurodegeneration) + bp(GO:"response to oxidative stress") increases p(HGNC:NFE2L2, loc(MESH:"Cell Nucleus")) - pmid:28420982 + pubmed:24563850 - p(HGNC:MAPT) increases bp(GO:"cell death") + bp(GO:"response to oxidative stress") increases act(p(FPLX:PRDX)) - pmid:28420982 + pubmed:27671637 - p(HGNC:MAPT) association bp(GO:behavior) + bp(GO:"response to oxidative stress") negativeCorrelation p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) - pmid:28420982 + pubmed:23528736 - p(HGNC:MAPT) decreases bp(GO:"synaptic signaling") + bp(GO:"response to oxidative stress") increases bp(GO:autophagy) - pmid:28420982 + pubmed:22419736 - p(HGNC:MAPT) association bp(GO:"intracellular signal transduction") + bp(GO:"response to oxidative stress") increases p(HGNC:AK1) - pmid:28420982 + pubmed:26751493 - tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"cell body")) association bp(MESH:Aging) + bp(GO:"response to oxidative stress") association a(CHEBI:"methylene blue") - pmid:28420982 + pubmed:26751493 - tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:dendrite)) association bp(MESH:Aging) + bp(GO:"response to oxidative stress") association a(CHEBI:"azure A") - pmid:28420982 + pubmed:26751493 - sec(p(HGNC:MAPT)) association a(MESH:Exosomes) + bp(GO:"response to oxidative stress") association a(CHEBI:"azure B") - pmid:29238289 + pubmed:27181519 - p(HGNC:MAPT) association act(a(MESH:Exosomes)) + bp(GO:"response to oxidative stress") increases complex(GO:"cytoplasmic stress granule") - pmid:28420982 + pubmed:29844403 - sec(p(HGNC:MAPT)) association a(GO:microvesicle) + bp(GO:"cellular respiration") negativeCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:28420982 + pubmed:30126037 - p(HGNC:MAPT) increases a(CHEBI:"calcium(2+)") + bp(GO:"cellular respiration") association act(a(MESH:Mitochondria)) - pmid:28420982 + pubmed:30046111 - p(HGNC:MAPT) increases bp(GO:"neuron death") + bp(GO:"immune response") association bp(GO:aging) - pmid:29238289 + pubmed:27288790 - p(HGNC:MAPT) causesNoChange bp(GO:"neuron death") + bp(GO:"immune response") association m(MIRBASE:hsa-mir-146a) - + + + pubmed:28843454 + + bp(GO:"immune response") association p(HGNCGENEFAMILY:"Histocompatibility complex") + - + + + pubmed:" 26517285" + + bp(GO:"immune response") association bp(GO:"microglial cell activation") + - + + + pubmed:" 26517285" + + bp(GO:"immune response") association g(HGNC:CR1) + - + + + pubmed:" 26517285" + + bp(GO:"immune response") association g(HGNC:CD33) + - + + + pubmed:" 26517285" + + bp(GO:"immune response") association g(HGNC:MS4A1) + - + + + pubmed:" 26517285" + + bp(GO:"immune response") association g(HGNC:ABCA7) + - + + + pubmed:" 26517285" + + bp(GO:"immune response") association g(HGNC:CLU) + - + + + pubmed:" 26517285" + + bp(GO:"immune response") association g(HGNC:EPHA1) + - + + + pubmed:30106381 + + bp(GO:"immune response") association p(HGNC:ADNP) + - + + + pubmed:30106381 + + bp(GO:"immune response") association a(PUBCHEM:9832404) + + + + pubmed:23746257 + + bp(GO:"immune response") association p(FPLX:HSP90) + + - pmid:16566606 + pubmed:30046111 - act(p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 394)) + bp(GO:"inflammatory response") association bp(GO:aging) - + + + pubmed:31346362 + + bp(GO:"inflammatory response") increases bp(GO:"cell death") + - + + + pubmed:31346362 + + bp(GO:"inflammatory response") increases deg(a(MESH:Tissues)) + + + + pubmed:29179999 + + bp(GO:"inflammatory response") association act(p(FPLX:NFkappaB)) + + - pmid:26751493 + pubmed:27794524 - p(HGNC:MAPT) decreases act(p(HGNC:HDAC6)) + bp(GO:"inflammatory response") negativeCorrelation bp(GO:"brain development") - pmid:26751493 + pubmed:27794524 - p(HGNC:MAPT) regulates bp(MESH:"Transcription, Genetic") + bp(GO:"inflammatory response") positiveCorrelation bp(GO:"central nervous system development") - pmid:26751493 + pubmed:27794524 - p(HGNC:MAPT) decreases bp(GO:autophagy) + bp(GO:"inflammatory response") increases path(MESH:"Disease Resistance") - + + + pubmed:27794524 + + bp(GO:"inflammatory response") positiveCorrelation path(MESH:"Neurodegenerative Diseases") + + + + pubmed:27794524 + + bp(GO:"inflammatory response") positiveCorrelation path(MESH:Atrophy) + + + + + pubmed:27794524 + + bp(GO:"inflammatory response") positiveCorrelation path(MESH:"Demyelinating Diseases") + + - pmid:26751493 + pubmed:27794524 - p(HGNC:MAPT) positiveCorrelation bp(GO:"clathrin-dependent endocytosis") + bp(GO:"inflammatory response") increases path(MESH:Pathology) + + + pubmed:23533697 + + bp(GO:"inflammatory response") association p(HGNC:TREM2) + + + + + pubmed:27522251 + + bp(GO:"inflammatory response") causesNoChange path(MESH:"Memory Disorders") + + - pmid:27373205 + pubmed:21958873 - p(HGNC:MAPT) increases a(HBP:"Tau oligomers") + bp(GO:"inflammatory response") negativeCorrelation a(CHEBI:Anatabine) - pmid:26631930 + pubmed:23178521 - p(HGNC:MAPT) directlyIncreases complex(p(HGNC:FYN), p(HGNC:MAPT)) + bp(GO:"inflammatory response") negativeCorrelation a(CHEBI:Anatabine) - pmid:18680553 + pubmed:30740335 - p(HGNC:MAPT) increases complex(p(HGNC:FYN), p(HGNC:MAPT)) + bp(GO:"inflammatory response") increases path(MESH:"Protein Unfolding") + + + pubmed:23746257 + + bp(GO:"inflammatory response") association bp(CONSO:Proteostasis) + + + + + pubmed:24563850 + + bp(GO:"inflammatory response") increases a(CHEBI:"reactive oxygen species") + + + + + pubmed:16566606 + + bp(GO:"inflammatory response") increases a(CHEBI:"reactive oxygen species") + + - pmid:26631930 + pubmed:8940412 - p(HGNC:MAPT) directlyIncreases p(HGNC:MAPT, pmod(Ac, Lys, 280)) + bp(GO:"inflammatory response") positiveCorrelation act(p(RGD:Crh)) + + + pubmed:8940412 + + bp(GO:"inflammatory response") negativeCorrelation a(CHEBI:antalarmin) + + + + + pubmed:30126037 + + bp(GO:"inflammatory response") association bp(GO:"cellular senescence") + + + + + pubmed:18494933 + + bp(GO:"inflammatory response") increases tloc(p(HGNC:DKK1), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + pubmed:18494933 + + bp(GO:"inflammatory response") positiveCorrelation p(HGNC:S100B) + + + + + pubmed:16566606 + + bp(GO:"inflammatory response") increases a(CHEBI:"reactive nitrogen species") + + + + + pubmed:16566606 + + bp(GO:"inflammatory response") increases a(CHEBI:peroxynitrite) + + + + + pubmed:30988501 + + bp(GO:"inflammatory response") increases bp(GO:"microglial cell activation") + + + + + pubmed:30988501 + + bp(GO:"inflammatory response") increases bp(MESH:"Transendothelial and Transepithelial Migration") + + + + + pubmed:30988501 + + bp(GO:"inflammatory response") increases act(a(MESH:T-Lymphocytes)) + + + + + pubmed:30046111 + + bp(GO:"phospholipid metabolic process") association bp(GO:aging) + + + + + pubmed:30046111 + + bp(GO:"extracellular matrix organization") association bp(GO:aging) + + + + + pubmed:30046111 + + bp(GO:"cell adhesion") association bp(GO:aging) + + + + + pubmed:21214928 + + bp(GO:"cell adhesion") association p(HGNC:APP) + + + + + pubmed:27190210 + + bp(GO:"cell adhesion") association p(HGNC:CHRNA7) + + - pmid:16566606 + pubmed:28901280 - act(p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) + bp(GO:"cell adhesion") association a(MESH:Acetylcholine) + + + pubmed:30106381 + + bp(GO:"cell adhesion") association p(HGNC:ADNP) + + - pmid:16566606 + pubmed:30106381 - act(p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) + bp(GO:"cell adhesion") association a(PUBCHEM:9832404) + + + pubmed:30046111 + + bp(GO:"endothelial tube morphogenesis") association bp(GO:aging) + + + + + pubmed:10998059 + + act(p(MGI:Cdk5r1)) increases p(MGI:Ppp1r1b, pmod(go:0006468 ! "protein phosphorylation")) + + + + + pubmed:19118186 + + p(MGI:Cdk5r1) increases act(p(MGI:Cdk5)) + + @@ -19289,853 +19861,798 @@

Statements

- pmid:26631930 + pubmed:27087442 - tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) association path(HBP:Neurodegeneration) + p(MGI:Cdk5r1) decreases bp(GO:"neuron death") - pmid:26631930 + pubmed:30046111 - act(p(HGNC:MAPT)) decreases path(HBP:Neurodegeneration) + p(MGI:Vegfc) increases a(MESH:"Lymphatic Vessels") - pmid:26631930 + pubmed:30046111 - p(HGNC:MAPT) association act(a(MESH:Dyneins)) + p(MGI:Vegfc) increases act(a(MESH:"Lymphatic Vessels")) - pmid:26631930 + pubmed:30046111 - p(HGNC:MAPT) association act(a(MESH:Kinesin)) + p(MGI:Vegfc) increases a(MESH:"Lymphatic Vessels") - pmid:26631930 + pubmed:30046111 - p(HGNC:MAPT) decreases complex(a(GO:microtubule), a(MESH:Dyneins)) + p(MGI:Vegfc) increases a(MESH:"Lymphatic Vessels") - pmid:22817713 + pubmed:30046111 - p(HGNC:MAPT) decreases complex(a(GO:microtubule), a(MESH:Dyneins)) + p(MGI:Vegfc) increases act(a(MESH:"Lymphatic Vessels")) - pmid:26631930 + pubmed:30046111 - p(HGNC:MAPT) decreases complex(a(GO:microtubule), a(MESH:Kinesin)) + p(MGI:Vegfc) causesNoChange a(MESH:"Lymphatic Vessels") + + + + - pmid:22817713 + pubmed:30046111 - p(HGNC:MAPT) decreases complex(a(GO:microtubule), a(MESH:Kinesin)) + p(MGI:Vegfc) increases path(MESH:"Spatial Learning") - pmid:26631930 + pubmed:30046111 - p(HGNC:MAPT) decreases bp(GO:"retrograde axonal transport") + p(MGI:Vegfc) increases bp(GO:"stem cell proliferation") - pmid:26631930 + pubmed:30046111 - p(HGNC:MAPT) increases act(p(HGNC:GSK3B)) + p(MGI:Vegfc) increases bp(GO:cognition) - pmid:26631930 + pubmed:30046111 - p(HGNC:MAPT) increases act(p(HGNC:PPP1R8)) + p(MGI:Vegfc) increases tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Cerebrospinal Fluid"), toLoc(MESH:"Lymph Nodes")) - pmid:26631930 + pubmed:30046111 - p(HGNC:MAPT) directlyIncreases complex(p(HGNC:DCTN1), p(HGNC:MAPT)) + p(MGI:Vegfc) causesNoChange tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Cerebrospinal Fluid"), toLoc(MESH:"Lymph Nodes")) - pmid:8391280 + pubmed:30046111 - p(HGNC:MAPT) isA complex(p(HGNC:DCTN1), p(HGNC:MAPT)) + p(MGI:Vegfc) causesNoChange a(CHEBI:amyloid-beta) - pmid:26631930 + pubmed:30046111 - p(HGNC:MAPT) increases a(MESH:Neurites) + p(MGI:Vegfc) causesNoChange path(HP:"Abnormal lymphatic vessel morphology") - pmid:26631930 + pubmed:30046111 - p(HGNC:MAPT) association bp(GO:"regulation of synaptic plasticity") + composite(a(CHEBI:"poly(ethylene glycol dimethacrylate)"), p(MGI:Vegfc)) increases a(MESH:"Lymphatic Vessels") + + - pmid:26631930 + pubmed:30046111 - p(HGNC:MAPT) increases path(HBP:Excitotoxicity) + p(MGI:Vegfc, var("p.Cys156Ser")) increases a(MESH:"Lymphatic Vessels") - pmid:26631930 + pubmed:30046111 - p(HGNC:MAPT) association bp(GO:neurogenesis) + p(MGI:Vegfc, var("p.Cys156Ser")) increases tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Cerebrospinal Fluid"), toLoc(MESH:Brain)) - pmid:26631930 + pubmed:30046111 - p(HGNC:MAPT) increases bp(GO:neurogenesis) + path(MESH:Inflammation) negativeCorrelation act(a(MESH:"Lymphatic Vessels")) - pmid:26631930 + pubmed:21329555 - p(HGNC:MAPT) decreases a(CHEBI:"iron(0)") + path(MESH:Inflammation) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:26631930 + pubmed:27288790 - p(HGNC:MAPT) decreases a(CHEBI:"iron(0)") + path(MESH:Inflammation) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:26631930 + pubmed:24027553 - p(HGNC:MAPT) increases bp(GO:locomotion) + path(MESH:Inflammation) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:26631930 + pubmed:21329555 - p(HGNC:MAPT) increases tloc(p(HGNC:APP), fromLoc(GO:cytoplasm), toLoc(GO:"cell surface")) + path(MESH:Inflammation) association bp(GO:"NIK/NF-kappaB signaling") - pmid:26631930 + pubmed:27288790 - p(HGNC:MAPT) increases bp(GO:"long-term synaptic depression") + path(MESH:Inflammation) association p(FPLX:NFkappaB) - pmid:26631930 + pubmed:27794524 - p(HGNC:MAPT) increases bp(GO:"long-term synaptic depression") + path(MESH:Inflammation) directlyDecreases path(MESH:"Epstein-Barr Virus Infections") - pmid:26631930 + pubmed:27794524 - p(HGNC:MAPT) directlyIncreases complex(a(MESH:Actins), p(HGNC:MAPT)) + path(MESH:Inflammation) association bp(GO:"microglial cell activation") - - - + + + pubmed:30967783 + + path(MESH:Inflammation) increases bp(GO:"microglial cell activation") + - + + + pubmed:30988501 + + path(MESH:Inflammation) increases bp(GO:"microglial cell activation") + - + + + pubmed:27956442 + + path(MESH:Inflammation) association path(MESH:"Multiple Sclerosis") + - pmid:26631930 + pubmed:27956442 - p(HGNC:MAPT) increases act(a(MESH:Brain)) + path(MESH:Inflammation) association path(MESH:"Demyelinating Diseases") - pmid:26631930 + pubmed:27956442 - p(HGNC:MAPT) negativeCorrelation path(MESH:Dementia) + path(MESH:Inflammation) association path(MESH:"Multiple Sclerosis, Relapsing-Remitting") - pmid:26631930 + pubmed:27956442 - p(HGNC:MAPT) increases bp(GO:"iron ion transport") + path(MESH:Inflammation) negativeCorrelation path(MESH:"Energy Metabolism") - pmid:26631930 + pubmed:27956442 - p(HGNC:MAPT) increases bp(GO:"DNA protection") + path(MESH:Inflammation) directlyIncreases path(NCIT:C95603) - pmid:26631930 + pubmed:30967783 - tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) regulates act(a(CHEBI:"amyloid-beta")) + path(MESH:Inflammation) increases act(a(MESH:Microglia, loc(NCIT:C74601))) - pmid:26631930 + pubmed:30967783 - p(HGNC:MAPT) increases act(a(CHEBI:"amyloid-beta")) + path(MESH:Inflammation) increases act(a(MESH:Macrophages, loc(MESH:"Choroid Plexus"))) - pmid:26631930 + pubmed:30967783 - tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) increases tloc(p(HGNC:TTLL6), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) + path(MESH:Inflammation) increases act(a(MESH:Macrophages, loc(NCIT:C83196))) - pmid:26631930 + pubmed:30967783 - p(HGNC:MAPT) increases complex(p(HGNC:DLG4), p(HGNC:FYN)) + path(MESH:Inflammation) increases act(a(MESH:Macrophages, loc(MESH:Meninges))) - pmid:22817713 + pubmed:30967783 - p(HGNC:MAPT) association bp(GO:"regulation of microtubule cytoskeleton organization") + path(MESH:Inflammation) association p(HGNC:TREM2) + + + pubmed:30967783 + + path(MESH:Inflammation) increases bp(GO:"macrophage activation") + + - pmid:29626319 + pubmed:30967783 - p(HGNC:MAPT) decreases p(HGNC:PSMD7) + path(MESH:Inflammation) increases path(DOID:"multiple sclerosis") - pmid:29238289 + pubmed:27190210 - p(HGNC:MAPT) association bp(GO:"microtubule polymerization") + path(MESH:Inflammation) association p(HGNC:CHRNA7) - pmid:2123288 + pubmed:29428175 - act(p(HGNC:MAPT)) increases bp(GO:"microtubule polymerization") + path(MESH:Inflammation) association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:16566606 + pubmed:29428175 - p(HGNC:MAPT) increases bp(GO:"microtubule polymerization") + path(MESH:Inflammation) association a(CHEBI:"cholinergic agonist") - pmid:29238289 + pubmed:26979166 - p(HGNC:MAPT) association a(MESH:Microtubules) + path(MESH:Inflammation) increases path(DOID:"mental depression") - pmid:29238289 + pubmed:26979166 - p(HGNC:MAPT, loc(GO:"extracellular region")) increases path(MESH:"Cytotoxicity, Immunologic") + path(MESH:Inflammation) association p(HGNC:CHI3L1) + + + pubmed:26979166 + + path(MESH:Inflammation) association p(HGNC:CCL2) + + - pmid:29238289 + pubmed:26979166 - sec(p(HGNC:MAPT)) association p(HGNC:RAB7A) + path(MESH:Inflammation) increases deg(a(MESH:"Cholinergic Neurons")) - pmid:29238289 + pubmed:22040696 - sec(p(HGNC:MAPT)) association p(HGNC:RAB1A) + path(MESH:Inflammation) increases path(MESH:"Renal Insufficiency") - pmid:29238289 + pubmed:30106381 - sec(p(HGNC:MAPT)) association a(MESH:"Transport Vesicles") + path(MESH:Inflammation) association p(HGNC:ADNP) - pmid:29238289 + pubmed:30012004 - p(HGNC:MAPT) decreases tloc(p(HBP:"Tau aggregates"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + path(MESH:Inflammation) positiveCorrelation path(MESH:"Huntington Disease") - - - - - - - - - - - - - - - - - pmid:1918161 + pubmed:24027553 - p(HGNC:MAPT) directlyIncreases complex(GO:microtubule) + path(MESH:Inflammation) increases act(p(HGNCGENEFAMILY:Caspases)) - pmid:6543144 + pubmed:26195256 - p(HGNC:MAPT) association complex(GO:microtubule) + path(MESH:Inflammation) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:10464280 + pubmed:26195256 - p(HGNC:MAPT) association complex(GO:microtubule) + path(MESH:Inflammation) decreases deg(a(CHEBI:amyloid-beta)) - - - pmid:1918161 + pubmed:30988501 - p(HGNC:MAPT) positiveCorrelation complex(GO:axon) + path(MESH:Inflammation) increases path(CONSO:neurotoxicity) - pmid:1918161 + pubmed:30988501 - p(HGNC:MAPT) positiveCorrelation complex(GO:"neuron projection") + path(MESH:Inflammation) increases path(CONSO:Neurodegeneration) - pmid:6543144 + pubmed:30988501 - p(HGNC:MAPT) association complex(GO:neurofilament) + path(MESH:Inflammation) decreases bp(GO:cognition) - pmid:2446784 + pubmed:30988501 - p(HGNC:MAPT) association complex(GO:"polysomal ribosome") + path(MESH:Inflammation) decreases bp(GO:cognition) - - - pmid:11812770 + pubmed:30988501 - p(HGNC:MAPT) positiveCorrelation complex(p(HGNC:GSK3B), p(HGNC:MAPT)) + path(MESH:Inflammation) association bp(GO:cognition) - pmid:18680553 + pubmed:30988501 - p(HGNC:MAPT) association p(HGNC:FYN) + path(MESH:Inflammation) decreases bp(GO:cognition) - - - pmid:18680553 + pubmed:30988501 - p(HGNC:MAPT) association bp(GO:myelination) + path(MESH:Inflammation) increases path(MESH:"Signs and Symptoms") - pmid:18467332 + pubmed:30988501 - p(HGNC:MAPT) association p(HGNC:SRC, frag("84_145")) + path(MESH:Inflammation) association path(DOID:obesity) - pmid:18467332 + pubmed:30988501 - p(HGNC:MAPT) isA complex(p(HGNC:MAPT), p(HGNC:SRC)) + path(MESH:Inflammation) decreases act(a(MESH:Neurons)) - pmid:18467332 + pubmed:30988501 - p(HGNC:MAPT) association p(HGNC:PLCG1, frag("790_851")) + path(MESH:Inflammation) increases deg(a(MESH:Neurons)) - pmid:18467332 + pubmed:30988501 - p(HGNC:MAPT) isA complex(p(HGNC:MAPT), p(HGNC:PLCG1)) + path(MESH:Inflammation) decreases a(MESH:"Blood-Brain Barrier") - pmid:18467332 + pubmed:30988501 - p(HGNC:MAPT) association p(HGNC:GRB2, frag("1_57")) + path(MESH:Inflammation) increases act(a(MESH:"Central Nervous System")) - pmid:18467332 + pubmed:30988501 - p(HGNC:MAPT) association complex(p(HGNC:GRB2), p(HGNC:MAPT)) + path(MESH:Inflammation) increases path(DOID:"learning disability") - pmid:18467332 + pubmed:30988501 - p(HGNC:MAPT) association p(HGNC:PIK3R1, frag("3_79")) + path(MESH:Inflammation) decreases bp(GO:"learning or memory") - pmid:18467332 + pubmed:30988501 - p(HGNC:MAPT) isA complex(p(HGNC:MAPT), p(HGNC:PIK3R1)) + path(MESH:Inflammation) decreases path(MESH:Attention) - pmid:10464280 + pubmed:30988501 - p(HGNC:MAPT) increases complex(complex(GO:microtubule), p(HGNC:MAPT)) + path(MESH:Inflammation) increases deg(a(GO:"myelin sheath")) - pmid:17954934 + pubmed:30988501 - p(HGNC:MAPT) isA complex(p(HGNC:BAG1), p(HGNC:MAPT), p(HGNC:STUB1)) + path(MESH:Inflammation) increases path(MESH:Recurrence) - pmid:17954934 + pubmed:29255009 - p(HGNC:MAPT) positiveCorrelation p(HGNC:BAG1) + p(MGI:Fkbp1b) increases path(MESH:Memory) - pmid:8391280 + pubmed:29255009 - p(HGNC:MAPT) increases act(p(INTERPRO:"Dynein associated protein")) + p(MGI:Fkbp1b) increases bp(MESH:Aging) - pmid:20071522 + pubmed:29255009 - p(HGNC:MAPT) isA complex(p(HGNC:FKBP5), p(HGNC:MAPT)) + p(MGI:Fkbp1b) increases act(p(MGI:Eif3g)) - pmid:21367866 + pubmed:29255009 - deg(p(HGNC:MAPT)) negativeCorrelation act(p(FPLX:HSP90)) + p(MGI:Fkbp1b) increases act(p(MGI:Pla2g7)) - pmid:2123288 + pubmed:29255009 - p(HGNC:MAPT) isA complex(p(FPLX:CALM), p(HGNC:MAPT)) + p(MGI:Fkbp1b) increases act(p(MGI:S100b)) - pmid:2123288 + pubmed:29255009 - act(p(HGNC:MAPT)) negativeCorrelation complex(a(CHEBI:"calcium(2+)"), p(FPLX:CALM), p(HGNC:MAPT)) + p(MGI:Fkbp1b) increases act(p(MGI:Snapc2)) - pmid:2833519 + pubmed:29255009 - p(HGNC:MAPT) association p(HGNC:S100B) + p(MGI:Fkbp1b) increases bp(MESH:"Facilitated Diffusion") - pmid:2833519 + pubmed:29255009 - p(HGNC:MAPT) isA complex(p(HGNC:MAPT), p(HGNC:S100B)) + p(MGI:Fkbp1b) increases bp(GO:"ectoderm development") - pmid:12551948 + pubmed:29255009 - p(HGNC:MAPT) association p(HGNC:YWHAZ) + p(MGI:Fkbp1b) increases bp(GO:"regulation of actin cytoskeleton organization") - pmid:12551948 + pubmed:29255009 - p(HGNC:MAPT) isA complex(p(HGNC:GSK3B), p(HGNC:MAPT), p(HGNC:YWHAZ)) + p(MGI:Fkbp1b) increases act(p(MESH:"Mitogen-Activated Protein Kinases")) - - - pmid:21339331 + pubmed:29255009 - p(HGNC:MAPT) association p(HGNC:ANXA2) + p(MGI:Fkbp1b) decreases act(p(MESH:"Membrane Transport Proteins")) - pmid:21339331 + pubmed:29255009 - p(HGNC:MAPT) isA complex(a(MESH:"Cell Membrane"), p(HGNC:ANXA2), p(HGNC:MAPT)) + p(MGI:Fkbp1b) decreases bp(GO:"blood vessel development") - pmid:21131359 + pubmed:29255009 - p(HGNC:MAPT) association a(CHEBI:"double-stranded DNA") + p(MGI:Fkbp1b) decreases bp(GO:"regulation of cellular component movement") - pmid:21131359 + pubmed:29255009 - p(HGNC:MAPT) isA complex(a(CHEBI:"double-stranded DNA"), p(HGNC:MAPT)) + p(MGI:Fkbp1b) decreases a(GO:"cytoplasmic vesicle") - pmid:21131359 + pubmed:29255009 - p(HGNC:MAPT) negativeCorrelation bp(MESH:"Hot Temperature") + p(MGI:Fkbp1b) increases p(MGI:Map2) - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - pmid:16566606 + pubmed:29255009 - act(p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) + p(MGI:Fkbp1b) negativeCorrelation a(CHEBI:"calcium(2+)") - pmid:16566606 + pubmed:29255009 - p(HGNC:MAPT) increases bp(GO:"tubulin complex assembly") + p(MGI:Fkbp1b) increases p(MGI:Capn1) - - - - - - - - - - - pmid:24869773 + pubmed:29255009 - p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 24)) + p(MGI:Fkbp1b) increases p(MGI:Ppp3cc) - - - pmid:24869773 + pubmed:29255009 - p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 44)) + p(MGI:Fkbp1b) increases p(MGI:Orai1) @@ -20144,1344 +20661,1262 @@

Statements

- pmid:24869773 + pubmed:29255009 - p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 67)) + p(MGI:Fkbp1b) decreases p(MGI:Hif1an) - - - pmid:24869773 + pubmed:29255009 - p(HGNC:MAPT) association p(HGNC:MAPT, pmod(Me, Lys, 190)) + p(MGI:Fkbp1b) decreases p(MGI:Nfkb1) - - - - - - - - - - - pmid:19251756 + pubmed:24762290 - p(HGNC:MAPT) association p(INTERPRO:"Triosephosphate isomerase", pmod(NO)) + path(MESH:Memory) association path(MESH:"Parkinson Disease") - pmid:19251756 + pubmed:24762290 - p(HGNC:MAPT) partOf complex(p(HGNC:MAPT), p(INTERPRO:"Triosephosphate isomerase", pmod(NO))) + path(MESH:Memory) association complex(CONSO:"alpha-4 beta-2 nAChR") - pmid:10537045 + pubmed:18986241 - p(HGNC:MAPT) positiveCorrelation p(HGNC:TGM2) + path(MESH:Memory) association path(MESH:"Cholinergic Neurons") - pmid:10537045 + pubmed:28901280 - p(HGNC:MAPT) partOf complex(p(HGNC:MAPT), p(HGNC:TGM2)) + path(MESH:Memory) association p(MESH:"Receptors, Nicotinic") - - - - - - - - - - - pmid:24853415 + pubmed:29255009 - p(HGNC:MAPT) positiveCorrelation p(HGNC:DAPK1) + p(CONSO:AAV-FKBP1B) increases p(MGI:Fkbp1b, loc(MESH:Hippocampus)) - pmid:24853415 + pubmed:29255009 - p(HGNC:MAPT) positiveCorrelation p(HGNC:PIN1, pmod(Ph, Ser, 71)) + p(CONSO:AAV-FKBP1B) increases g(MGI:Fkbp1b, loc(MESH:Hippocampus)) - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - pmid:25652642 + pubmed:29255009 - a(GO:"neurofibrillary tangle") positiveCorrelation act(complex(GO:"NF-kappaB complex")) + bp(MESH:Aging) decreases p(MGI:Map2) - pmid:29196815 + pubmed:29255009 - a(GO:"neurofibrillary tangle") positiveCorrelation path(MESH:"Alzheimer Disease") + bp(MESH:Aging) decreases p(MGI:Capn1) - pmid:28420982 + pubmed:29255009 - a(GO:"neurofibrillary tangle") positiveCorrelation path(MESH:"Alzheimer Disease") + bp(MESH:Aging) decreases p(MGI:Ppp3cc) - pmid:22817713 + pubmed:29255009 - a(GO:"neurofibrillary tangle") association path(MESH:"Alzheimer Disease") + bp(MESH:Aging) decreases p(MGI:Orai1) - pmid:11089576 + pubmed:24511233 - a(GO:"neurofibrillary tangle") positiveCorrelation path(MESH:"Alzheimer Disease") + bp(MESH:Aging) association path(MESH:"Alzheimer Disease") - pmid:24653673 + pubmed:23528736 - a(GO:"neurofibrillary tangle") association p(FPLX:PPP2, pmod(Me, Tyr, 307)) + bp(MESH:Aging) increases path(MESH:"Alzheimer Disease") - pmid:29758300 + pubmed:25437566 - a(GO:"neurofibrillary tangle") association p(HGNC:BECN1, frag("?")) + bp(MESH:Aging) increases p(HGNC:TPR) - pmid:22908190 + pubmed:25437566 - a(GO:"neurofibrillary tangle") association a(HBP:"paired helical filaments") + bp(MESH:Aging) increases p(HGNC:TPR) - pmid:22908190 + pubmed:25437566 - a(GO:"neurofibrillary tangle") association a(MESH:Ubiquitin) + bp(MESH:Aging) increases p(HGNC:TPR) - pmid:22908190 + pubmed:27491084 - a(GO:"neurofibrillary tangle") negativeCorrelation act(complex(GO:"proteasome complex")) + bp(MESH:Aging) increases p(HGNC:TPR) - pmid:22908190 + pubmed:25437566 - a(GO:"neurofibrillary tangle") negativeCorrelation p(HGNC:UCHL1, pmod(GO:"protein oxidation")) + bp(MESH:Aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") - pmid:22908190 + pubmed:25437566 - a(GO:"neurofibrillary tangle") association bp(GO:"protein K63-linked ubiquitination") + bp(MESH:Aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") - pmid:22908190 + pubmed:25437566 - a(GO:"neurofibrillary tangle") association p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + bp(MESH:Aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") - pmid:18930136 + pubmed:25437566 - a(GO:"neurofibrillary tangle") association p(HGNC:SQSTM1) + bp(MESH:Aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") - pmid:27671637 + pubmed:27491084 - a(GO:"neurofibrillary tangle") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) + bp(MESH:Aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") - pmid:30126037 + pubmed:25784053 - a(GO:"neurofibrillary tangle") decreases bp(GO:cognition) + bp(MESH:Aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") - pmid:30126037 + pubmed:25437566 - a(GO:"neurofibrillary tangle") increases bp(GO:"cell death") + bp(MESH:Aging) decreases p(FPLX:HSPA) - pmid:30126037 + pubmed:25437566 - a(GO:"neurofibrillary tangle") decreases bp(GO:"cell death") + bp(MESH:Aging) decreases p(FPLX:HSPA) - pmid:30126037 + pubmed:27491084 - a(GO:"neurofibrillary tangle") positiveCorrelation p(MGI:Cdkn2a) + bp(MESH:Aging) decreases p(FPLX:HSPA) - pmid:30126037 + pubmed:25784053 - a(GO:"neurofibrillary tangle") increases act(p(MGI:Cdkn2a)) + bp(MESH:Aging) decreases p(FPLX:HSPA) - pmid:30126037 + pubmed:25437566 - a(GO:"neurofibrillary tangle") increases p(MGI:Cdkn2a) + bp(MESH:Aging) increases p(FPLX:HSPB) - pmid:30126037 + pubmed:25437566 - a(GO:"neurofibrillary tangle") increases p(MGI:Cdkn2a) + bp(MESH:Aging) increases p(FPLX:HSPB) - pmid:30126037 + pubmed:27491084 - a(GO:"neurofibrillary tangle") association bp(GO:"cellular senescence") + bp(MESH:Aging) increases p(FPLX:HSPB) - pmid:30126037 + pubmed:25784053 - a(GO:"neurofibrillary tangle") increases bp(MESH:"Cell Survival") + bp(MESH:Aging) increases p(FPLX:HSPB) - pmid:30126037 + pubmed:25437566 - a(GO:"neurofibrillary tangle") increases bp(GO:"inflammatory response") + bp(MESH:Aging) decreases p(HGNC:HSPD1) - pmid:30126037 + pubmed:27491084 - a(GO:"neurofibrillary tangle") increases bp(GO:"cell cycle") + bp(MESH:Aging) decreases p(HGNC:HSPD1) - pmid:30126037 + pubmed:25437566 - a(GO:"neurofibrillary tangle") decreases bp(GO:"apoptotic process") + bp(MESH:Aging) increases p(HGNC:HSPA2) - pmid:30126037 + pubmed:25437566 - a(GO:"neurofibrillary tangle") decreases path(MESH:Necrosis) + bp(MESH:Aging) increases p(HGNC:DNAJB2) - pmid:30126037 + pubmed:25437566 - a(GO:"neurofibrillary tangle") increases p(HGNC:NFKB1) + bp(MESH:Aging) decreases p(HGNC:HSPA12A) - pmid:30126037 + pubmed:25437566 - a(GO:"neurofibrillary tangle") increases p(HGNC:IFNG) + bp(MESH:Aging) decreases p(HGNC:TOMM70) - pmid:30126037 + pubmed:25437566 - a(GO:"neurofibrillary tangle") increases p(HGNC:TNF) + bp(MESH:Aging) decreases p(HGNC:HSP90AB1) - pmid:30126037 + pubmed:25437566 - a(GO:"neurofibrillary tangle") increases p(HGNC:TLR4) + bp(MESH:Aging) decreases p(HGNC:HSPA8) - pmid:30126037 + pubmed:25437566 - a(GO:"neurofibrillary tangle") increases p(HGNC:IL1B) + bp(MESH:Aging) decreases p(HGNC:HSPA14) - pmid:30126037 + pubmed:25437566 - a(GO:"neurofibrillary tangle") increases p(HGNC:CXCL1) + bp(MESH:Aging) decreases p(HGNC:TCP1) - pmid:30126037 + pubmed:25784053 - a(GO:"neurofibrillary tangle") increases act(p(MGI:Ifng)) + bp(MESH:Aging) regulates bp(CONSO:Proteostasis) - pmid:30126037 + pubmed:25784053 - a(GO:"neurofibrillary tangle") increases act(p(MGI:Tnf)) + bp(MESH:Aging) decreases p(FPLX:HSP90) - pmid:30126037 + pubmed:29311797 - a(GO:"neurofibrillary tangle") increases act(p(MGI:Il1b)) + bp(MESH:Aging) increases p(FPLX:HSP90) - pmid:30126037 + pubmed:29311797 - a(GO:"neurofibrillary tangle") increases act(p(MGI:Jak1)) + bp(MESH:Aging) decreases p(FPLX:HSP90) - pmid:30126037 + pubmed:29311797 - a(GO:"neurofibrillary tangle") increases act(p(MGI:Stat1)) + bp(MESH:Aging) decreases p(FPLX:HSP90) - pmid:30126037 + pubmed:25784053 - a(GO:"neurofibrillary tangle") increases act(p(MGI:Bcl2)) + bp(MESH:Aging) decreases p(FPLX:"CCT_complex") - pmid:30126037 + pubmed:23528736 - a(GO:"neurofibrillary tangle") association p(HGNC:CDKN2A) + bp(MESH:Aging) decreases bp(GO:autophagy) - pmid:30126037 + pubmed:23528736 - a(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:CDKN2A) + bp(MESH:Aging) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:30126037 + pubmed:28420982 - a(GO:"neurofibrillary tangle") increases p(HGNC:CDKN2A) + bp(MESH:Aging) association tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"cell body")) - pmid:30126037 + pubmed:28420982 - a(GO:"neurofibrillary tangle") decreases bp(GO:"oxygen transport") + bp(MESH:Aging) association tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:dendrite)) - pmid:30126037 + pubmed:29311797 - a(GO:"neurofibrillary tangle") association path(MESH:"Hypertrophy, Right Ventricular") + bp(MESH:Aging) association path(MESH:"Neurodegenerative Diseases") - pmid:30126037 + pubmed:29311797 - a(GO:"neurofibrillary tangle") association path(MESH:"Hypertrophy, Left Ventricular") + bp(MESH:Aging) decreases bp(GO:"protein folding") - pmid:30126037 + pubmed:29311797 - a(GO:"neurofibrillary tangle") association path(HP:"Brain atrophy") + bp(MESH:Aging) increases path(MESH:"Protein Aggregation, Pathological") - pmid:30985105 + pubmed:29311797 - deg(a(GO:"neurofibrillary tangle")) negativeCorrelation p(MESH:Proteins, pmod(HBP:"O-GlcNAcylation")) + bp(MESH:Aging) decreases bp(MESH:Proteolysis) - pmid:26751493 + pubmed:29311797 - a(GO:"neurofibrillary tangle") negativeCorrelation r(HGNC:SYP) + bp(MESH:Aging) decreases act(p(FPLX:Proteasome)) - pmid:26751493 + pubmed:29311797 - a(GO:"neurofibrillary tangle") negativeCorrelation p(HGNC:SNAP25) + bp(MESH:Aging) decreases act(p(FPLX:Proteasome)) - pmid:26751493 + pubmed:29311797 - a(GO:"neurofibrillary tangle") negativeCorrelation p(PFAM:Syntaxin) + bp(MESH:Aging) decreases bp(GO:"chaperone-mediated autophagy") - pmid:23531502 + pubmed:29311797 - a(GO:"neurofibrillary tangle") association act(a(CHEBI:acrolein)) + bp(MESH:Aging) decreases bp(GO:"chaperone-mediated autophagy") - pmid:12578227 + pubmed:29311797 - a(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:TGM1) + bp(MESH:Aging) decreases p(HGNC:PPID) - pmid:12578227 + pubmed:29311797 - a(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:TGM2) + bp(MESH:Aging) decreases p(HGNC:PPID) - pmid:11089576 + pubmed:29311797 - a(GO:"neurofibrillary tangle") positiveCorrelation act(p(ECCODE:"2.3.2.13")) + bp(MESH:Aging) increases p(HGNC:FKBP5) - pmid:11738469 + pubmed:29311797 - a(GO:"neurofibrillary tangle") positiveCorrelation act(p(ECCODE:"2.3.2.13")) + bp(MESH:Aging) increases p(HGNC:FKBP5) - pmid:8985134 + pubmed:29311797 - a(GO:"neurofibrillary tangle") positiveCorrelation act(p(ECCODE:"2.3.2.13")) + bp(MESH:Aging) decreases p(HGNC:PPP5C) - pmid:11089576 + pubmed:29311797 - a(GO:"neurofibrillary tangle") positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") + bp(MESH:Aging) decreases p(HGNC:PPP5C) - pmid:9099822 + pubmed:29311797 - a(GO:"neurofibrillary tangle") positiveCorrelation act(p(HGNCGENEFAMILY:Transglutaminases)) + bp(MESH:Aging) decreases p(HGNC:AHSA1) - pmid:23088643 + pubmed:29311797 - a(GO:"neurofibrillary tangle") association p(HBP:"Tau epitope, AT8") + bp(MESH:Aging) decreases p(HGNC:AHSA1) - pmid:23088643 + pubmed:29311797 - a(GO:"neurofibrillary tangle") association p(HGNC:MAPT, pmod(Ph, Ser, 422)) + bp(MESH:Aging) decreases p(HGNC:FKBP4) - pmid:26751493 + pubmed:29311797 - a(GO:"neurofibrillary tangle") negativeCorrelation p(INTERPRO:"Syntaxin, N-terminal domain") + bp(MESH:Aging) decreases p(HGNC:STIP1) - pmid:26118667 + pubmed:29311797 - a(GO:"neurofibrillary tangle") positiveCorrelation p(HBP:"CDK5R1 p25") + bp(MESH:Aging) decreases p(HGNC:PTGES3) - pmid:29844403 + pubmed:29311797 - a(GO:"neurofibrillary tangle") positiveCorrelation a(HBP:"Tau aggregates") + bp(MESH:Aging) increases p(FPLX:HSP90, pmod(go:0006468 ! "protein phosphorylation")) - pmid:21734277 + pubmed:29311797 - a(GO:"neurofibrillary tangle") decreases bp(GO:"axonal transport") + bp(MESH:Aging) increases p(FPLX:HSP90, pmod(go:0006473 ! "protein acetylation")) - pmid:21734277 + pubmed:29311797 - a(GO:"neurofibrillary tangle") increases act(p(FPLX:PPP1)) + bp(MESH:Aging) increases p(FPLX:HSP90, pmod(go:0017014 ! "protein nitrosylation")) - pmid:21734277 + pubmed:29311797 - a(GO:"neurofibrillary tangle") increases act(p(HGNC:GSK3B)) + bp(MESH:Aging) increases p(FPLX:HSP90, pmod(go:0016567 ! "protein ubiquitination")) - pmid:23832849 + pubmed:29255009 - a(GO:"neurofibrillary tangle") association p(HGNC:FKBP1A) + p(MGI:Eif3g) increases bp(MESH:Aging) - pmid:30663117 + pubmed:29255009 - g(HGNC:"MIR9-1") decreases a(GO:"neurofibrillary tangle") + p(MGI:Pla2g7) increases bp(MESH:Aging) - pmid:30663117 + pubmed:29255009 - g(HGNC:"MIR9-1") decreases act(p(HGNC:MAP2K2)) + p(MGI:S100b) increases bp(MESH:Aging) - pmid:30663117 + pubmed:29255009 - g(HGNC:"MIR9-1") association path(MESH:"Alzheimer Disease") + p(MGI:Snapc2) increases bp(MESH:Aging) - pmid:30663117 + pubmed:29255009 - act(p(HGNC:MAP2K2)) increases a(GO:"neurofibrillary tangle") + path(MESH:Aging) decreases bp(MESH:"Facilitated Diffusion") - pmid:30663117 + pubmed:29255009 - a(MESH:"RNA, Long Noncoding") increases bp(GO:"apoptotic process") + path(MESH:Aging) decreases bp(GO:"ectoderm development") - pmid:28745240 + pubmed:29255009 - bp(GO:"apoptotic process") negativeCorrelation p(HGNC:RELA) + path(MESH:Aging) decreases bp(GO:"regulation of actin cytoskeleton organization") - pmid:27288790 + pubmed:29255009 - bp(GO:"apoptotic process") association p(FPLX:NFkappaB) + path(MESH:Aging) decreases act(p(MESH:"Mitogen-Activated Protein Kinases")) - pmid:19293145 + pubmed:29255009 - bp(GO:"apoptotic process") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + path(MESH:Aging) increases act(p(MESH:"Membrane Transport Proteins")) - pmid:24653673 + pubmed:29255009 - bp(GO:"apoptotic process") positiveCorrelation act(p(HGNC:GSK3B)) + path(MESH:Aging) increases bp(GO:"blood vessel development") - pmid:24653673 + pubmed:29255009 - bp(GO:"apoptotic process") positiveCorrelation act(p(HGNC:CDK5)) + path(MESH:Aging) increases bp(GO:"regulation of cellular component movement") - pmid:24653673 + pubmed:29255009 - bp(GO:"apoptotic process") positiveCorrelation act(p(FPLX:ERK)) + path(MESH:Aging) increases a(GO:"cytoplasmic vesicle") - pmid:30012004 + pubmed:29255009 - bp(GO:"apoptotic process") positiveCorrelation path(MESH:"Huntington Disease") + path(MESH:Aging) increases p(MGI:Hif1an) - pmid:24027553 + pubmed:29255009 - bp(GO:"apoptotic process") increases act(p(HGNCGENEFAMILY:Calpains)) + path(MESH:Aging) increases p(MGI:Nfkb1) - pmid:24027553 + pubmed:27794524 - bp(GO:"apoptotic process") increases p(HGNC:MAPT, frag("?", "17kD")) + path(MESH:Aging) decreases path(MESH:Inflammation) - pmid:24027553 + pubmed:27794524 - bp(GO:"apoptotic process") increases act(p(HGNC:CASP6)) + path(MESH:Aging) increases path(MESH:"Neurodegenerative Diseases") - pmid:26304819 + pubmed:19126755 - bp(GO:"apoptotic process") association r(HGNC:GAPDH) + path(MESH:Aging) negativeCorrelation p(CONSO:"alpha-4 beta-2 nAChR") - pmid:23948915 + pubmed:19126755 - bp(GO:"apoptotic process") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) + path(MESH:Aging) negativeCorrelation p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:23948915 + pubmed:19126755 - bp(GO:"apoptotic process") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) + path(MESH:Aging) decreases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:23948915 + pubmed:19126755 - bp(GO:"apoptotic process") negativeCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 231)) + path(MESH:Aging) decreases p(MGI:Chrna4) - pmid:30663117 + pubmed:19126755 - g(HGNC:EBF3) isA a(MESH:"RNA, Long Noncoding") + path(MESH:Aging) negativeCorrelation p(MGI:Chrna4) - pmid:30663117 + pubmed:19126755 - bp(GO:"neuron death") increases g(MGI:Ebf3) + path(MESH:Aging) negativeCorrelation p(MGI:Chrna7) - pmid:30444369 + pubmed:18986241 - bp(GO:"neuron death") association p(HGNC:SH3GL2) + path(MESH:Aging) association bp(MESH:"Oxidative Stress") - pmid:29196815 + pubmed:30362565 - bp(GO:"neuron death") positiveCorrelation a(HBP:HBP00074) + path(MESH:Aging) increases path(MESH:"Motor Skills Disorders") - pmid:21214928 + pubmed:30362565 - bp(GO:"neuron death") association complex(a(HBP:HBP00042), p(HGNC:TNFRSF21)) + path(MESH:Aging) increases path(MESH:Ataxia) - pmid:22122372 + pubmed:26195256 - bp(GO:"neuron death") association path(MESH:"Alzheimer Disease") + path(MESH:Aging) increases path(MESH:"Alzheimer Disease") - pmid:17009926 + pubmed:26195256 - bp(GO:"neuron death") positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:Aging) negativeCorrelation a(MESH:"Cerebrospinal Fluid") - pmid:17009926 + pubmed:26195256 - bp(GO:"neuron death") positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:Aging) negativeCorrelation act(p(HGNC:AQP1)) - pmid:25514383 + pubmed:26091809 - bp(GO:"neuron death") positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:Aging) positiveCorrelation p(HGNC:TARDBP) - pmid:21722302 + pubmed:29255009 - bp(GO:"neuron death") prognosticBiomarkerFor path(MESH:"Alzheimer Disease") + a(CHEBI:"calcium(2+)") negativeCorrelation p(MGI:Fkbp1b) - pmid:28420982 + pubmed:24107444 - bp(GO:"neuron death") positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:"calcium(2+)") positiveCorrelation bp(GO:"long-term synaptic potentiation") - pmid:26631930 + pubmed:24107444 - bp(GO:"neuron death") positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:"calcium(2+)") positiveCorrelation bp(MESH:"Neuronal Plasticity") - pmid:21787755 + pubmed:19126755 - bp(GO:"neuron death") association a(HBP:"alpha-7-containing nAChR") + a(CHEBI:"calcium(2+)", loc(GO:intracellular)) regulates bp(MESH:"Neuronal Plasticity") - pmid:30012004 + pubmed:29428175 - bp(GO:"neuron death") increases path(MESH:Atrophy) + tloc(a(CHEBI:"calcium(2+)"), fromLoc(GO:"endoplasmic reticulum"), toLoc(MESH:Cytoplasm)) increases bp(MESH:"Neuronal Plasticity") - pmid:30012004 + pubmed:24107444 - bp(GO:"neuron death") positiveCorrelation path(MESH:"Huntington Disease") + a(CHEBI:"calcium(2+)") positiveCorrelation tloc(a(CHEBI:"L-glutamic acid"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:30012004 + pubmed:31346362 - bp(GO:"neuron death") positiveCorrelation path(MESH:"Huntington Disease") + a(CHEBI:"calcium(2+)", loc(MESH:Cytosol)) increases bp(GO:"membrane lipid catabolic process") - pmid:21722302 + pubmed:31346362 - bp(GO:"neuron death") association p(HGNC:PRNP) + a(CHEBI:"calcium(2+)", loc(MESH:Cytosol)) increases act(p(HGNCGENEFAMILY:Calpains)) - pmid:29758300 + pubmed:24027553 - bp(GO:"neuron death") association path(MESH:"Neurodegenerative Diseases") + a(CHEBI:"calcium(2+)") increases act(p(HGNCGENEFAMILY:Calpains)) - pmid:14556719 + pubmed:24027553 - bp(GO:"neuron death") positiveCorrelation path(MESH:"Parkinson Disease") + a(CHEBI:"calcium(2+)", loc(GO:intracellular)) increases act(p(HGNCGENEFAMILY:Calpains)) - pmid:22908190 + pubmed:24027553 - bp(GO:"neuron death") positiveCorrelation act(p(HGNC:RAB5A)) + a(CHEBI:"calcium(2+)", loc(GO:intracellular)) increases act(p(HGNCGENEFAMILY:Calpains)) - pmid:24027553 + pubmed:31346362 - bp(GO:"neuron death") negativeCorrelation bp(MESH:Autophagy) + a(CHEBI:"calcium(2+)", loc(MESH:Cytosol)) increases act(p(MESH:Deoxyribonucleases)) - pmid:21882945 + pubmed:27794524 - bp(GO:"neuron death") positiveCorrelation path(MESH:Tauopathies) + a(CHEBI:"calcium(2+)", loc(GO:axon)) directlyIncreases path(MESH:"Neurodegenerative Diseases") - pmid:28420982 + pubmed:27794524 - bp(GO:"neuron death") association path(MESH:Tauopathies) + a(CHEBI:"calcium(2+)", loc(GO:axon)) increases a(MESH:Calpain) - pmid:30663117 + pubmed:27794524 - a(HBP:"alpha-synuclein aggregates") association path(MESH:"Parkinson Disease") + a(CHEBI:"calcium(2+)", loc(GO:axon)) increases a(MESH:Phospholipases) - pmid:30663117 + pubmed:27794524 - a(HBP:"alpha-synuclein aggregates") increases path(MESH:"Parkinson Disease") + a(CHEBI:"calcium(2+)", loc(GO:axon)) negativeCorrelation p(MESH:"Microtubule Proteins", pmod(go:0006468 ! "protein phosphorylation")) - pmid:30663117 + pubmed:27794524 - a(HBP:"alpha-synuclein aggregates") decreases a(MESH:"Dopaminergic Neurons") + a(CHEBI:"calcium(2+)", loc(GO:axon)) negativeCorrelation p(MESH:"Neurofilament Proteins", pmod(go:0006468 ! "protein phosphorylation")) - pmid:30663117 + pubmed:19126755 - a(HBP:"alpha-synuclein aggregates") negativeCorrelation a(MESH:"HSP70 Heat-Shock Proteins") + a(CHEBI:"calcium(2+)", loc(GO:intracellular)) increases act(p(FPLX:CREB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) - pmid:29758300 + pubmed:19126755 - a(HBP:"alpha-synuclein aggregates") association path(MESH:"Alzheimer Disease") + a(CHEBI:"calcium(2+)", loc(GO:intracellular)) increases a(CHEBI:anandamide) - pmid:29758300 + pubmed:19126755 - a(HBP:"alpha-synuclein aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:"calcium(2+)", loc(GO:intracellular)) regulates bp(GO:"signal release") - pmid:14556719 + pubmed:19126755 - a(HBP:"alpha-synuclein aggregates") association a(MESH:"Lewy Bodies") + a(CHEBI:"calcium(2+)", loc(GO:intracellular)) regulates bp(GO:"neuron migration") - pmid:14556719 + pubmed:22040696 - a(HBP:"alpha-synuclein aggregates") positiveCorrelation path(MESH:"Parkinsonian Disorders") + tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:Cytoplasm)) increases bp(GO:"neuron migration") - pmid:14556719 + pubmed:19126755 - a(HBP:"alpha-synuclein aggregates") decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + a(CHEBI:"calcium(2+)", loc(GO:intracellular)) regulates bp(GO:"neuron differentiation") + + - pmid:30116051 + pubmed:19293145 - a(HBP:"alpha-synuclein aggregates") decreases complex(GO:"proteasome complex") + a(CHEBI:"calcium(2+)") association act(p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors")) - pmid:30985105 + pubmed:23038257 - a(HBP:"alpha-synuclein aggregates") decreases bp(GO:"neuron death") + a(CHEBI:"calcium(2+)") increases act(p(MESH:"Receptors, Nicotinic")) - pmid:30985105 + pubmed:17009926 - a(HBP:"alpha-synuclein aggregates") negativeCorrelation a(HBP:"alpha-synuclein oligomers") + tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Intracellular Space"), toLoc(GO:cytosol)) - pmid:21482353 + pubmed:26472524 - a(MESH:"Dopaminergic Neurons") positiveCorrelation a(HBP:"alpha-4 beta-2 nAChR") + tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) increases bp(GO:"membrane depolarization") - pmid:19721446 + pubmed:20556492 - a(MESH:"Dopaminergic Neurons") association complex(p(HGNC:CHRNA4), p(HGNC:CHRNA6), p(HGNC:CHRNB2), p(HGNC:CHRNB3)) + a(CHEBI:"calcium(2+)") regulates bp(GO:"membrane depolarization") - pmid:19721446 + pubmed:26472524 - a(MESH:"Dopaminergic Neurons") association complex(p(HGNC:CHRNA6), p(HGNC:CHRNB2), p(HGNC:CHRNB3)) + a(CHEBI:"calcium(2+)") regulates act(p(FPLX:CHRN)) - pmid:19721446 + pubmed:26813123 - a(MESH:"Dopaminergic Neurons") association complex(p(HGNC:CHRNA6), p(HGNC:CHRNB2)) + a(CHEBI:"calcium(2+)") regulates p(FPLX:CHRN) - pmid:19721446 + pubmed:26813123 - a(MESH:"Dopaminergic Neurons") association complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) + a(CHEBI:"calcium(2+)") increases tloc(a(CHEBI:"glutamate(2-)"), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) - pmid:19721446 + pubmed:26813123 - a(MESH:"Dopaminergic Neurons") association complex(p(HGNC:CHRNA4), p(HGNC:CHRNA5), p(HGNC:CHRNB2)) + a(CHEBI:"calcium(2+)") increases tloc(a(CHEBI:"gamma-aminobutyric acid"), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) - pmid:28901280 + pubmed:26813123 - a(MESH:"Dopaminergic Neurons") regulates a(MESH:Nicotine) + a(CHEBI:"calcium(2+)") increases tloc(a(CHEBI:dopamine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) - pmid:14556719 + pubmed:26813123 - a(MESH:"Dopaminergic Neurons") negativeCorrelation p(HGNC:PRKN) + a(CHEBI:"calcium(2+)") increases tloc(a(CHEBI:serotonin), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) - pmid:30663117 + pubmed:26813123 - p(HGNC:SNCA) association bp(GO:"synaptic transmission, dopaminergic") + a(CHEBI:"calcium(2+)") increases tloc(a(CHEBI:noradrenaline), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) - - - pmid:30663117 + pubmed:26813123 - p(HGNC:SNCA) positiveCorrelation a(GO:"Lewy body", loc(MESH:"Dopaminergic Neurons")) + a(CHEBI:"calcium(2+)") increases tloc(a(CHEBI:acetylcholine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) @@ -21490,71 +21925,63 @@

Statements

- pmid:29758300 + pubmed:29428175 - p(HGNC:SNCA) positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:"calcium(2+)", loc(MESH:Cytoplasm)) regulates tloc(a(CHEBI:neurotransmitter), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:29758300 + pubmed:29428175 - p(HGNC:SNCA) increases path(MESH:"Alzheimer Disease") + a(CHEBI:"calcium(2+)", loc(MESH:"Endoplasmic Reticulum")) increases p(HGNC:CAMK2A) - pmid:29758300 + pubmed:29428175 - p(HGNC:SNCA) increases path(MESH:"Parkinson Disease") + a(CHEBI:"calcium(2+)", loc(MESH:"Endoplasmic Reticulum")) increases a(CHEBI:calcineurin) - pmid:28803412 + pubmed:29428175 - p(HGNC:SNCA) association path(MESH:"Parkinson Disease") + tloc(a(CHEBI:"calcium(2+)", loc(MESH:"Endoplasmic Reticulum")), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) decreases act(p(HGNC:MAPK14)) - pmid:29980653 + pubmed:29428175 - p(HGNC:SNCA) positiveCorrelation path(MESH:"Parkinson Disease") + tloc(a(CHEBI:"calcium(2+)", loc(MESH:"Endoplasmic Reticulum")), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) decreases tloc(p(HGNC:TNF), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - - - pmid:29758300 + pubmed:29428175 - p(HGNC:SNCA) association bp(GO:"chaperone-mediated autophagy") + tloc(a(CHEBI:"calcium(2+)", loc(MESH:"Endoplasmic Reticulum")), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) decreases p(HGNC:NFKB1) - - - - - - - pmid:14556719 + pubmed:29428175 - p(HGNC:SNCA) association p(HGNC:SNCAIP) + tloc(a(CHEBI:"calcium(2+)", loc(MESH:"Endoplasmic Reticulum")), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) decreases p(HGNC:IFNG) @@ -21563,54 +21990,56 @@

Statements

- pmid:22908190 + pubmed:26088141 - p(HGNC:SNCA) positiveCorrelation p(HGNC:SNCA, pmod(Ub)) + a(CHEBI:"calcium(2+)") association act(a(MESH:"Calcium Channels")) - pmid:14556719 + pubmed:19721446 - p(HGNC:SNCA) regulates bp(GO:"dopamine secretion, neurotransmission") + a(CHEBI:"calcium(2+)") increases act(p(HGNC:CHRNA7)) - pmid:14556719 + pubmed:19721446 - p(HGNC:SNCA) regulates bp(GO:"dopamine secretion") + a(CHEBI:"calcium(2+)") increases act(p(CONSO:"alpha-4 beta-2 nAChR")) - pmid:30985105 + pubmed:20556492 - p(HGNC:SNCA) association bp(GO:"dopamine secretion") + a(CHEBI:"calcium(2+)") regulates complex(GO:"mitochondrial permeability transition pore complex") + + - pmid:14556719 + pubmed:26968346 - p(HGNC:SNCA) positiveCorrelation bp(HBP:"Alpha-synuclein Oligomerization") + a(CHEBI:"calcium(2+)", loc(GO:cytoplasm)) increases act(complex(GO:"calcineurin complex")) - pmid:14556719 + pubmed:27299292 - p(HGNC:SNCA) increases bp(GO:"apoptotic process") + tloc(a(CHEBI:"calcium(2+)"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) regulates act(p(HGNC:PPP3CA), ma(go:0016791 ! "phosphatase activity")) @@ -21619,110 +22048,96 @@

Statements

- pmid:14556719 + pubmed:2123288 - act(p(HGNC:SNCA)) increases p(HGNC:SNCAIP, pmod(Ub)) + a(CHEBI:"calcium(2+)") increases act(p(FPLX:CALM)) + + + + - pmid:14556719 + pubmed:2833519 - act(p(HGNC:SNCA)) increases p(HGNC:TH, pmod(Ub)) + a(CHEBI:"calcium(2+)") increases act(p(HGNC:S100B)) - pmid:14556719 + pubmed:10537045 - act(p(HGNC:SNCA)) regulates bp(GO:"homeostatic process") + a(CHEBI:"calcium(2+)") positiveCorrelation complex(p(HGNC:MAPT), p(HGNC:TGM2)) + + - pmid:14556719 + pubmed:30837838 - p(HGNC:SNCA) association a(MESH:"Inclusion Bodies") + a(CHEBI:"calcium(2+)") association bp(GO:"neuron fate commitment") - pmid:22908190 + pubmed:30837838 - p(HGNC:SNCA) increases complex(a(GO:"Lewy body"), p(HGNC:SNCA)) + a(CHEBI:"calcium(2+)") association path(MESH:"Nerve Degeneration") - pmid:25784053 + pubmed:30837838 - p(HGNC:SNCA) decreases bp(GO:autophagy) + a(CHEBI:"calcium(2+)") increases bp(GO:"neuron death") - pmid:25784053 + pubmed:23702978 - p(HGNC:SNCA) decreases p(HGNC:RAB1A) + a(CHEBI:"calcium(2+)") association p(HGNC:MAP3K7) - - - - - - - - - - - pmid:30985105 + pubmed:23702978 - p(HGNC:SNCA) regulates a(GO:"synaptic vesicle") + tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) increases act(p(HGNC:NLRP3)) - - - - - - - - - - - pmid:30985105 + pubmed:19118186 - p(HGNC:SNCA) increases a(HBP:"alpha-synuclein fibrils") + p(MGI:Capn1) negativeCorrelation p(MGI:Ttbk1) - pmid:29980653 + pubmed:29255009 - tloc(p(HGNC:SNCA), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) increases a(HBP:"alpha-synuclein fibrils") + a(CHEBI:sirolimus) decreases bp(CONSO:"PI3K-Akt signaling pathway") @@ -21731,532 +22146,510 @@

Statements

- - - - - - - pmid:30663117 + pubmed:29661268 - bp(GO:"synaptic transmission, dopaminergic") association p(HGNC:SNCA) + a(CHEBI:sirolimus) increases p(HGNC:ULK1, pmod(go:0006468 ! "protein phosphorylation")) - pmid:14556719 + pubmed:29661268 - bp(GO:"synaptic transmission, dopaminergic") negativeCorrelation path(MESH:"Parkinson Disease") + a(CHEBI:sirolimus) negativeCorrelation bp(GO:autophagy) - pmid:30663117 + pubmed:30061532 - p(HGNC:SNCA, var("?")) increases path(MESH:"Parkinson Disease") + a(CHEBI:sirolimus) increases bp(GO:autophagy) - pmid:18930136 + pubmed:30688256 - p(HGNC:SNCA, var("?")) increases path(MESH:"Parkinson Disease") + a(CHEBI:sirolimus) increases bp(GO:autophagy) - pmid:30985105 + pubmed:26968346 - p(HGNC:SNCA, var("?")) increases path(MESH:"Parkinson Disease") + a(CHEBI:sirolimus) positiveCorrelation bp(GO:autophagy) - pmid:30061532 + pubmed:29758300 - p(HGNC:SNCA, var("?")) association path(MESH:"Psychotic Disorders") + a(CHEBI:sirolimus) increases bp(GO:autophagy) - pmid:27491084 + pubmed:22908190 - p(HGNC:SNCA, var("?")) association path(HP:Neurodegeneration) + a(CHEBI:sirolimus) increases bp(GO:autophagy) - pmid:29758300 + pubmed:22908190 - p(HGNC:SNCA, var("?")) association bp(GO:"chaperone-mediated autophagy") + a(CHEBI:sirolimus) increases bp(GO:autophagy) - pmid:14556719 + pubmed:18930136 - p(HGNC:SNCA, var("?")) association path(MESH:"Parkinsonian Disorders") + a(CHEBI:sirolimus) increases bp(GO:autophagy) - pmid:14556719 + pubmed:30116051 - p(HGNC:SNCA, var("?")) increases bp(GO:"apoptotic process") + a(CHEBI:sirolimus) increases bp(GO:autophagy) - pmid:18930136 + pubmed:23528736 - p(HGNC:SNCA, var("?")) decreases tloc(p(HGNC:SNCA, var("?")), fromLoc(GO:cytoplasm), toLoc(GO:"lysosomal lumen")) + a(CHEBI:sirolimus) increases bp(GO:autophagy) - pmid:30116051 + pubmed:29626319 - p(HGNC:SNCA, var("?")) decreases bp(GO:"autophagosome assembly") + a(CHEBI:sirolimus) increases bp(GO:autophagy) - pmid:30116051 + pubmed:27181519 - p(HGNC:SNCA, var("?")) decreases a(GO:"lysosomal membrane") + a(CHEBI:sirolimus) increases bp(GO:autophagy) - pmid:30116051 + pubmed:29661268 - p(HGNC:SNCA, var("?")) decreases complex(GO:"proteasome complex") + a(CHEBI:sirolimus) negativeCorrelation act(p(HGNC:PPP2CA)) - pmid:30663117 + pubmed:30061532 - a(GO:"Lewy body", loc(MESH:"Dopaminergic Neurons")) positiveCorrelation p(HGNC:SNCA) + a(CHEBI:sirolimus) decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:21722302 + pubmed:30061532 - a(GO:"Lewy body") increases p(MESH:"alpha-Synuclein") + a(CHEBI:sirolimus) decreases p(HGNC:SNCA, pmod(CONSO:misfolded)) - pmid:21722302 + pubmed:30061532 - a(GO:"Lewy body") biomarkerFor path(MESH:"Parkinson Disease") + a(CHEBI:sirolimus) decreases p(HGNC:TARDBP, pmod(CONSO:misfolded)) - pmid:21722302 + pubmed:30061532 - a(GO:"Lewy body") increases p(MESH:"alpha-Synuclein", pmod(HBP:misfolded)) + a(CHEBI:sirolimus) increases path(MESH:"Interpersonal Relations") - pmid:22908190 + pubmed:30061532 - a(GO:"Lewy body") association a(MESH:Ubiquitin) + a(CHEBI:sirolimus) increases bp(GO:behavior) - pmid:22908190 + pubmed:30061532 - a(GO:"Lewy body") association a(MESH:Ubiquitin) + a(CHEBI:sirolimus) decreases act(a(CHEBI:methamphetamine)) - pmid:22908190 + pubmed:30061532 - a(GO:"Lewy body") positiveCorrelation path(MESH:Dementia) + a(CHEBI:sirolimus) decreases path(MESH:"Psychotic Disorders") - pmid:22908190 + pubmed:30061532 - a(GO:"Lewy body") positiveCorrelation path(MESH:Dementia) + a(CHEBI:sirolimus) decreases path(MESH:"Psychotic Disorders") - pmid:22908190 + pubmed:30061532 - a(GO:"Lewy body") association p(HGNC:MAPT) + a(CHEBI:sirolimus) decreases path(MESH:Schizophrenia) - pmid:18930136 + pubmed:30688256 - a(GO:"Lewy body") association p(HGNC:SQSTM1) + a(CHEBI:sirolimus) decreases path(MESH:"Neurodegenerative Diseases") - pmid:30663117 + pubmed:30688256 - g(HGNC:"MIR7-1") regulates p(HGNC:SNCA) + a(CHEBI:sirolimus) increases a(HBP:"huntingtin aggregates") - pmid:30663117 + pubmed:26968346 - g(HGNC:"MIR7-1") decreases p(HGNC:SNCA) + a(CHEBI:sirolimus) decreases p(HGNC:MTOR) - pmid:30663117 + pubmed:29758300 - g(HGNC:"MIR7-1") regulates p(HGNC:SNCA) + a(CHEBI:sirolimus) decreases act(p(HGNC:MTOR)) - pmid:30663117 + pubmed:18930136 - g(HGNC:"MIR7-1") decreases path(MESH:"Parkinson Disease") + a(CHEBI:sirolimus) decreases act(p(HGNC:MTOR)) - - - - - pmid:30663117 + pubmed:30985105 - complex(g(HGNC:"MIR153-1"), r(HGNC:SNCA)) decreases act(p(HGNC:SNCA)) + a(CHEBI:sirolimus) decreases act(p(HGNC:MTOR)) - pmid:30663117 + pubmed:30837838 - complex(g(HGNC:"MIR153-1"), r(HGNC:SNCA)) decreases p(HGNC:SNCA) + a(CHEBI:sirolimus) decreases p(HGNC:MTOR) - - - - - pmid:30663117 + pubmed:26968346 - complex(g(HGNC:"MIR7-1"), r(HGNC:SNCA)) decreases act(p(HGNC:SNCA)) + a(CHEBI:sirolimus) increases p(HGNC:TFEB) - pmid:30663117 + pubmed:26968346 - complex(g(HGNC:"MIR7-1"), r(HGNC:SNCA)) decreases p(HGNC:SNCA) + a(CHEBI:sirolimus) decreases act(p(HGNC:SNCA, var("?"))) - - - - - pmid:30663117 + pubmed:26968346 - g(HGNC:MIR34B) increases p(HGNC:PARK7) + a(CHEBI:sirolimus) decreases p(CONSO:PrPSc) - - - pmid:30663117 + pubmed:27299292 - g(HGNC:MIR34C) increases p(HGNC:PARK7) + a(CHEBI:sirolimus) increases composite(a(CHEBI:sirolimus), p(HGNC:TFEB, frag("?_*"))) - pmid:30663117 + pubmed:29758300 - g(HGNC:MIR132) regulates p(HGNC:SNCA) + a(CHEBI:sirolimus) increases bp(GO:cognition) - pmid:30663117 + pubmed:29758300 - g(HGNC:MIR132) decreases p(HGNC:SNCA) + a(CHEBI:sirolimus) decreases a(CHEBI:amyloid-beta) - pmid:30663117 + pubmed:29758300 - g(HGNC:MIR132) regulates p(HGNC:SNCA) + a(CHEBI:sirolimus) decreases a(CHEBI:amyloid-beta) - pmid:30663117 + pubmed:22908190 - g(HGNC:MIR132) association path(MESH:"Parkinson Disease") + a(CHEBI:sirolimus) decreases a(CHEBI:amyloid-beta) - pmid:30663117 + pubmed:29626319 - g(HGNC:MIR132) decreases path(MESH:"Parkinson Disease") + a(CHEBI:sirolimus) decreases a(CHEBI:amyloid-beta) - pmid:30663117 + pubmed:29758300 - g(HGNC:MIR132) association p(HGNC:NR4A2) + a(CHEBI:sirolimus) increases bp(GO:macroautophagy) - pmid:26631930 + pubmed:29758300 - g(HGNC:MIR132) negativeCorrelation path(MESH:"Supranuclear Palsy, Progressive") + a(CHEBI:sirolimus) increases bp(GO:macroautophagy) - pmid:26631930 + pubmed:26751493 - g(HGNC:MIR132) decreases p(HBP:"4R tau") + a(CHEBI:sirolimus) increases bp(GO:macroautophagy) - pmid:30663117 + pubmed:29758300 - p(HGNC:NR4A2) association g(HGNC:MIR132) + a(CHEBI:sirolimus) decreases p(HGNC:MAPT) - pmid:30663117 + pubmed:23528736 - g(NCBIGENE:406950) association path(MESH:"Parkinson Disease") + a(CHEBI:sirolimus) increases deg(p(HGNC:MAPT)) - pmid:30663117 + pubmed:29758300 - g(NCBIGENE:406950) decreases a(MESH:"HSP70 Heat-Shock Proteins") + a(CHEBI:sirolimus) increases bp(GO:"motor behavior") - pmid:30663117 + pubmed:27181519 - g(NCBIGENE:406950) negativeCorrelation a(MESH:"HSP70 Heat-Shock Proteins") + a(CHEBI:sirolimus) increases bp(GO:"motor behavior") + + - pmid:30663117 + pubmed:22908190 - g(NCBIGENE:406950) increases a(HBP:"alpha-synuclein aggregates") + a(CHEBI:sirolimus) decreases path(MESH:Tauopathies) - pmid:30663117 + pubmed:22908190 - a(MESH:"HSP70 Heat-Shock Proteins") negativeCorrelation a(HBP:"alpha-synuclein aggregates") + a(CHEBI:sirolimus) decreases path(MESH:Tauopathies) - pmid:30663117 + pubmed:25784053 - a(MESH:"HSP70 Heat-Shock Proteins") decreases a(HBP:"alpha-synuclein aggregates") + a(CHEBI:sirolimus) decreases act(p(FPLX:mTORC1)) - pmid:30663117 + pubmed:25784053 - a(MESH:"HSP70 Heat-Shock Proteins") negativeCorrelation g(NCBIGENE:406950) + a(CHEBI:sirolimus) decreases path(MESH:"Protein Aggregation, Pathological") - pmid:25374103 + pubmed:25784053 - a(MESH:"HSP70 Heat-Shock Proteins") increases deg(p(HGNC:MAPT, pmod(HBP:misfolded))) + a(CHEBI:sirolimus) decreases path(MESH:"Huntington Disease") - - - pmid:30663117 + pubmed:18930136 - complex(a(MESH:"HSP70 Heat-Shock Proteins"), g(NCBIGENE:406950)) regulates act(a(MESH:"HSP70 Heat-Shock Proteins")) + a(CHEBI:sirolimus) decreases path(MESH:"Huntington Disease") - - - pmid:30663117 + pubmed:25784053 - g(HGNC:MIR133B) decreases path(MESH:"Parkinson Disease") + a(CHEBI:sirolimus) decreases path(MESH:"Machado-Joseph Disease") - pmid:30663117 + pubmed:25784053 - g(HGNC:MIR133B) regulates p(HGNC:SNCA) + a(CHEBI:sirolimus) decreases path(MESH:"Alzheimer Disease") - pmid:30663117 + pubmed:25784053 - p(HGNC:LRRK2) association path(MESH:"Parkinson Disease") + a(CHEBI:sirolimus) decreases path(MESH:"Parkinson Disease") - pmid:24113872 + pubmed:25784053 - p(HGNC:LRRK2) positiveCorrelation path(MESH:"Parkinson Disease") + a(CHEBI:sirolimus) decreases path(MESH:"Amyotrophic Lateral Sclerosis") @@ -22265,375 +22658,351 @@

Statements

- - - pmid:30663117 - - p(HGNC:LRRK2) decreases g(HGNC:MIRLET7A1) - - - pmid:30663117 + pubmed:18930136 - p(HGNC:LRRK2) decreases act(g(HGNC:MIRLET7A1)) + a(CHEBI:sirolimus) decreases path(MESH:"Bulbo-Spinal Atrophy, X-Linked") - - - pmid:30663117 - - p(HGNC:LRRK2) decreases g(HGNC:MIR184) - - - pmid:30663117 + pubmed:27594586 - p(HGNC:LRRK2) decreases act(g(HGNC:MIR184)) + a(CHEBI:sirolimus) decreases bp(GO:"TOR signaling") - pmid:24113872 + pubmed:27594586 - act(p(HGNC:LRRK2), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 149)) + a(CHEBI:sirolimus) increases r(HGNC:MMP9) - pmid:24113872 + pubmed:27594586 - act(p(HGNC:LRRK2), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 153)) + a(CHEBI:sirolimus) increases r(HGNC:MMP2) + + - pmid:24113872 + pubmed:30116051 - act(p(HGNC:LRRK2), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 205)) + a(CHEBI:sirolimus) decreases p(HGNC:SNCA) - pmid:24113872 + pubmed:30985105 - act(p(HGNC:LRRK2), ma(kin)) directlyIncreases p(HBP:"Tau aggregates") + a(CHEBI:sirolimus) decreases p(HGNC:SNCA) - pmid:24113872 + pubmed:27181519 - act(p(HGNC:LRRK2), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 199)) + a(CHEBI:sirolimus) increases deg(p(HGNC:SNCA)) - pmid:24113872 + pubmed:30116051 - act(p(HGNC:LRRK2), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 202)) + a(CHEBI:sirolimus) decreases p(HGNC:FUS) - pmid:30663117 + pubmed:27181519 - p(HGNC:LRRK2, var("?")) increases bp(GO:"neuron death") + a(CHEBI:sirolimus) decreases p(HGNC:FUS, loc(GO:"cytoplasmic stress granule")) - pmid:21722302 + pubmed:30116051 - p(HGNC:LRRK2, var("?")) increases path(DOID:"autosomal dominant Parkinson's disease 1") + a(CHEBI:sirolimus) decreases p(HGNC:HTT) - pmid:21722302 + pubmed:27181519 - p(HGNC:LRRK2, var("?")) decreases bp(GO:"protein catabolic process") + a(CHEBI:sirolimus) increases deg(p(HGNC:HTT)) - pmid:21722302 + pubmed:24027553 - p(HGNC:LRRK2, var("?")) increases a(HBP:"alpha-synuclein aggregates") + a(CHEBI:sirolimus) increases bp(MESH:Autophagy) - pmid:21722302 + pubmed:29626319 - p(HGNC:LRRK2, var("?")) increases a(MESH:"Ubiquitinated Proteins") + a(CHEBI:sirolimus) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:21722302 + pubmed:27181519 - p(HGNC:LRRK2, var("?")) decreases bp(GO:"lysosomal protein catabolic process") + a(CHEBI:sirolimus) increases deg(complex(GO:"cytoplasmic stress granule")) - pmid:21722302 + pubmed:27181519 - p(HGNC:LRRK2, var("?")) decreases bp(GO:"regulation of protein oxidation") + a(CHEBI:sirolimus) increases bp(GO:locomotion) - pmid:21722302 + pubmed:27181519 - p(HGNC:LRRK2, var("?")) increases bp(GO:"inflammatory response") + a(CHEBI:sirolimus) increases a(MESH:Neurites) - pmid:21722302 + pubmed:27181519 - p(HGNC:LRRK2, var("?")) increases bp(MESH:Apoptosis) + a(CHEBI:sirolimus) decreases bp(GO:"cell death") - pmid:30116051 + pubmed:30837838 - p(HGNC:LRRK2, var("?")) association path(MESH:"Parkinson Disease") + a(CHEBI:sirolimus) increases path(MESH:Autophagy) - pmid:30116051 + pubmed:30837838 - p(HGNC:LRRK2, var("?")) decreases bp(GO:autophagy) + a(CHEBI:sirolimus) increases bp(GO:"autophagosome assembly") - pmid:30116051 + pubmed:30837838 - p(HGNC:LRRK2, var("?")) decreases act(p(HGNC:BECN1)) + a(CHEBI:sirolimus) increases path(MESH:Proteolysis) - pmid:30116051 + pubmed:30837838 - p(HGNC:LRRK2, var("?")) association bp(HBP:"APP processing") + a(CHEBI:sirolimus) increases path(MESH:Memory) - pmid:30116051 + pubmed:30837838 - p(HGNC:LRRK2, var("?")) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + a(CHEBI:sirolimus) increases path(MESH:"Motor Activity") - pmid:30663117 + pubmed:30837838 - p(HGNC:LRRK2, var("p.Gly2019Ser")) increases path(MESH:"Parkinson Disease") + a(CHEBI:sirolimus) decreases p(HGNC:CASP3) - pmid:28803412 + pubmed:30837838 - p(HGNC:LRRK2, var("p.Gly2019Ser")) increases path(MESH:"Neurodegenerative Diseases") + a(CHEBI:sirolimus) decreases p(HGNC:TARDBP, loc(GO:cytoplasm)) - pmid:30663117 + pubmed:29255009 - g(HGNC:MIR205) regulates p(HGNC:LRRK2) + bp(CONSO:"PI3K-Akt signaling pathway") causesNoChange act(p(MGI:Fkbp1b)) - pmid:30663117 + pubmed:28745240 - g(HGNC:MIR205) regulates p(HGNC:LRRK2) + bp(CONSO:"PI3K-Akt signaling pathway") increases act(complex(GO:"NF-kappaB complex")) - pmid:30663117 + pubmed:28745240 - g(HGNC:MIRLET7A1) decreases p(HGNC:E2F1) + bp(CONSO:"PI3K-Akt signaling pathway") increases act(complex(GO:"NF-kappaB complex")) - pmid:30663117 + pubmed:31248781 - g(HGNC:MIRLET7A1) decreases act(p(HGNC:E2F1)) + bp(CONSO:"PI3K-Akt signaling pathway") association p(HGNC:CREBBP) - pmid:30663117 + pubmed:31248781 - g(HGNC:MIRLET7A1) decreases p(HGNC:TFDP1) + bp(CONSO:"PI3K-Akt signaling pathway") association bp(MESH:Neuroprotection) - pmid:30663117 + pubmed:29255009 - g(HGNC:MIRLET7A1) decreases act(p(HGNC:TFDP1)) + act(complex(a(CHEBI:sirolimus), p(MGI:Fkbp1b))) decreases bp(CONSO:"PI3K-Akt signaling pathway") - pmid:30663117 + pubmed:29255009 - g(HGNC:MIR184) decreases p(HGNC:E2F1) + act(complex(a(CHEBI:sirolimus), p(MGI:Fkbp1a))) decreases bp(CONSO:"PI3K-Akt signaling pathway") + + - pmid:30663117 + pubmed:29255009 - g(HGNC:MIR184) decreases act(p(HGNC:E2F1)) + p(MGI:Fkbp1a) decreases bp(CONSO:"PI3K-Akt signaling pathway") - pmid:30663117 + pubmed:30126037 - g(HGNC:MIR184) decreases p(HGNC:TFDP1) + act(p(MGI:Nfkb1)) increases bp(MESH:"Cell Survival") - pmid:30663117 + pubmed:30126037 - g(HGNC:MIR184) decreases act(p(HGNC:TFDP1)) + act(p(MGI:Nfkb1)) increases bp(GO:"inflammatory response") - pmid:30663117 + pubmed:30663117 - p(HGNC:PARK7) decreases a(HBP:"alpha-synuclein aggregates") + r(HGNC:BACE1, loc(GO:cytoplasm)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:30663117 + pubmed:30663117 - p(HGNC:PARK7) decreases bp(GO:"apoptotic process") + r(HGNC:BACE1) increases path(MESH:"Alzheimer Disease") - pmid:30663117 + pubmed:21329555 - p(HGNC:PARK7) decreases bp(GO:"neuron death") + r(HGNC:BACE1) positiveCorrelation path(MESH:"Alzheimer Disease") - - - pmid:21722302 - - p(HGNC:PARK7) increases bp(GO:"detection of redox state") - - - - - pmid:21722302 - - p(HGNC:PARK7) regulates bp(MESH:"Protein Stability") - - @@ -22642,3555 +23011,3176 @@

Statements

- pmid:30663117 + pubmed:29179999 - path(MESH:Chorea) association path(MESH:"Huntington Disease") + r(HGNC:BACE1) association act(p(FPLX:NFkappaB)) - pmid:29687724 + pubmed:27288790 - path(MESH:Chorea) association path(MESH:"Huntington Disease") + r(HGNC:BACE1) decreases p(HGNC:UCHL1) - pmid:29687724 + pubmed:27288790 - path(MESH:Chorea) association path(MESH:"Neural Pathways") + r(HGNC:BACE1) decreases act(p(HGNC:UCHL1)) - pmid:29687724 + pubmed:30663117 - path(MESH:Chorea) association a(CHEBI:dopamine) + r(HGNC:BACE1-AS) biomarkerFor path(MESH:"Alzheimer Disease") - pmid:30663117 + pubmed:30663117 - path(MESH:Dementia) association path(MESH:"Huntington Disease") + r(HGNC:BACE1-AS) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:30012004 + pubmed:30663117 - path(MESH:Dementia) positiveCorrelation path(MESH:"Huntington Disease") + r(HGNC:BACE1-AS) increases r(HGNC:BACE1) - pmid:19126755 + pubmed:27288790 - path(MESH:Dementia) positiveCorrelation path(MESH:"Alzheimer Disease") + r(HGNC:BACE1-AS) regulates r(HGNC:BACE1) - pmid:19293145 + pubmed:27288790 - path(MESH:Dementia) association path(MESH:"Alzheimer Disease") + r(HGNC:BACE1-AS) decreases deg(r(HGNC:BACE1)) - pmid:24511233 + pubmed:30663117 - path(MESH:Dementia) association path(MESH:"Alzheimer Disease") + r(HGNC:BACE1-AS) increases a(CHEBI:amyloid-beta) - pmid:25514383 + pubmed:30663117 - path(MESH:Dementia) association path(MESH:"Alzheimer Disease") + r(HGNC:BACE1-AS) increases path(MESH:"Plaque, Amyloid") - pmid:26813123 + pubmed:27288790 - path(MESH:Dementia) association bp(GO:"synaptic transmission, cholinergic") + r(HGNC:BACE1-AS) regulates p(HGNC:BACE1) - pmid:25514383 + pubmed:27288790 - path(MESH:Dementia) association bp(GO:aging) + r(HGNC:BACE1-AS) increases a(CHEBI:"amyloid-beta polypeptide 42") - pmid:29758300 + pubmed:25652642 - path(MESH:Dementia) association path(MESH:Tauopathies) + path(MESH:"Plaque, Amyloid") positiveCorrelation act(complex(GO:"NF-kappaB complex")) - pmid:22908190 + pubmed:25652642 - path(MESH:Dementia) positiveCorrelation a(GO:"Lewy body") + path(MESH:"Plaque, Amyloid") association complex(GO:"NF-kappaB complex") - pmid:22908190 + pubmed:25652642 - path(MESH:Dementia) positiveCorrelation a(GO:"Lewy body") + path(MESH:"Plaque, Amyloid") association a(MESH:"HLA-DR Antigens") - pmid:22908190 + pubmed:29196815 - path(MESH:Dementia) positiveCorrelation p(HGNC:SNCA, pmod(Ub)) + path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:26631930 + pubmed:19126755 - path(MESH:Dementia) negativeCorrelation p(HGNC:MAPT) + path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27314526 + pubmed:19293145 - path(MESH:Dementia) association sec(a(MESH:Interleukins)) + path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27314526 + pubmed:19293145 - path(MESH:Dementia) positiveCorrelation p(HGNC:IL1B) + path(MESH:"Plaque, Amyloid") biomarkerFor path(MESH:"Alzheimer Disease") - pmid:27314526 + pubmed:19293145 - path(MESH:Dementia) positiveCorrelation p(HGNC:IL18) + path(MESH:"Plaque, Amyloid") association path(MESH:"Alzheimer Disease") - pmid:30663117 + pubmed:24511233 - path(MESH:"Deglutition Disorders") association path(MESH:"Huntington Disease") + path(MESH:"Plaque, Amyloid") biomarkerFor path(MESH:"Alzheimer Disease") - pmid:30663117 + pubmed:24590577 - path(MESH:Aphasia) association path(MESH:"Huntington Disease") + path(MESH:"Plaque, Amyloid") association path(MESH:"Alzheimer Disease") - pmid:30663117 + pubmed:25514383 - path(MESH:Seizures) association path(MESH:"Huntington Disease") + path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:21787755 + pubmed:29758300 - path(MESH:Seizures) association a(HBP:"alpha-7-containing nAChR") + path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:30663117 + pubmed:22817713 - p(HGNC:HTT, var("?")) increases path(MESH:"Huntington Disease") + path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:14556719 + pubmed:21871088 - p(HGNC:HTT, var("?")) increases path(MESH:"Huntington Disease") + path(MESH:"Plaque, Amyloid") increases bp(GO:"microglial cell activation") - pmid:14556719 + pubmed:19293145 - p(HGNC:HTT, var("?")) increases a(HBP:"huntingtin aggregates") + path(MESH:"Plaque, Amyloid") association p(HGNC:CHRNA7) - pmid:14556719 + pubmed:19293145 - p(HGNC:HTT, var("?")) decreases act(complex(GO:"proteasome complex")) + path(MESH:"Plaque, Amyloid") causesNoChange r(HGNC:CHRNA4) - pmid:14556719 + pubmed:19293145 - p(HGNC:HTT, var("?")) increases bp(GO:"cell cycle arrest") + path(MESH:"Plaque, Amyloid") causesNoChange r(HGNC:CHRNA7) - pmid:14556719 + pubmed:24511233 - p(HGNC:HTT, var("?")) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + path(MESH:"Plaque, Amyloid") association a(CONSO:"amyloid-beta aggregates") - pmid:14556719 + pubmed:26195256 - p(HGNC:HTT, var("?")) decreases act(p(HBP:"20 S Proteasome")) + path(MESH:"Plaque, Amyloid") association a(CONSO:"amyloid-beta aggregates") - pmid:14556719 + pubmed:24511233 - p(HGNC:HTT, var("?")) decreases deg(p(HGNC:TP53)) + path(MESH:"Plaque, Amyloid") increases path(CONSO:neuroinflammation) - pmid:14556719 + pubmed:24511233 - p(HGNC:HTT, var("?")) decreases bp(MESH:"Membrane Potential, Mitochondrial") + path(MESH:"Plaque, Amyloid") increases bp(GO:"cell death") - pmid:14556719 + pubmed:24590577 - p(HGNC:HTT, var("?")) increases sec(a(CHEBI:"cytochrome c")) + path(MESH:"Plaque, Amyloid") association bp(GO:"synaptic transmission, cholinergic") - pmid:14556719 + pubmed:25514383 - p(HGNC:HTT, var("?")) increases act(p(FPLX:Caspase)) + path(MESH:"Plaque, Amyloid") association complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7)) - pmid:14556719 + pubmed:18986241 - p(HGNC:HTT, var("?")) increases bp(GO:"apoptotic process") + path(MESH:"Plaque, Amyloid") association p(HGNC:BCHE) - pmid:25784053 + pubmed:18986241 - p(HGNC:HTT, var("?")) increases p(FPLX:HSPA) + path(MESH:"Plaque, Amyloid") association p(HGNC:ACHE) - pmid:30116051 + pubmed:26010758 - p(HGNC:HTT, var("?")) decreases bp(GO:autophagy) + path(MESH:"Plaque, Amyloid") association p(FPLX:NFkappaB, pmod(go:0006468 ! "protein phosphorylation", Ser, 536)) - pmid:30116051 + pubmed:27299292 - p(HGNC:HTT, var("?")) decreases bp(GO:"cargo loading into vesicle") + path(MESH:"Plaque, Amyloid") negativeCorrelation p(HGNC:TFEB) - pmid:30116051 + pubmed:14556719 - p(HGNC:HTT, var("?")) decreases bp(GO:"autophagosome assembly") + path(MESH:"Plaque, Amyloid") association a(MESH:"Amyloid beta-Peptides") - - - - - pmid:14556719 + pubmed:24027553 - p(HGNC:HTT) increases complex(p(HGNC:HTT), p(HGNC:UBA2)) + path(MESH:"Plaque, Amyloid") association p(HGNC:MAP1LC3A) - - - pmid:30985105 + pubmed:28420982 - p(HGNC:HTT) association bp(GO:"vesicle transport along microtubule") + path(MESH:"Plaque, Amyloid") association a(MESH:Exosomes) - pmid:30985105 + pubmed:26195256 - p(HGNC:HTT) association p(HGNC:BDNF) + path(MESH:"Plaque, Amyloid") negativeCorrelation act(p(HGNC:MMP2)) - pmid:30985105 + pubmed:26195256 - p(HGNC:HTT) decreases bp(GO:"apoptotic process") + path(MESH:"Plaque, Amyloid") increases act(a(MESH:Astrocytes)) - - - pmid:30663117 + pubmed:18562203 - g(HGNC:MIR196A1) association path(MESH:"Huntington Disease") + path(MESH:"Plaque, Amyloid") association act(a(MESH:Astrocytes)) - pmid:30663117 + pubmed:23531502 - g(HGNC:MIR206) association path(MESH:"Huntington Disease") + path(MESH:"Plaque, Amyloid") association act(a(CHEBI:acrolein)) - pmid:30663117 + pubmed:18562203 - g(HGNC:MIR301B) association path(MESH:"Huntington Disease") + path(MESH:"Plaque, Amyloid") positiveCorrelation p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 18)) - pmid:30663117 + pubmed:26400044 - g(HGNC:MIR92B) association path(MESH:"Huntington Disease") + path(MESH:"Plaque, Amyloid") association complex(p(MGI:Dpysl2, pmod(go:0006468 ! "protein phosphorylation")), p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation")), p(MGI:Wasf1, pmod(go:0006468 ! "protein phosphorylation"))) - pmid:30663117 + pubmed:23088643 - g(HGNC:MIR378B) association path(MESH:"Huntington Disease") + path(MESH:"Plaque, Amyloid") association p(CONSO:"Tau epitope, AT8") - pmid:30663117 + pubmed:28877763 - g(HGNC:MIR208B) association path(MESH:"Huntington Disease") + path(MESH:"Plaque, Amyloid") association a(CONSO:"dystrophic neurite") - pmid:30663117 + pubmed:24401760 - g(HGNC:MIR449A) association path(MESH:"Huntington Disease") + path(MESH:"Plaque, Amyloid") association a(CONSO:"dystrophic neurite") - pmid:30663117 + pubmed:28877763 - g(HGNC:MIR22) decreases bp(GO:"neuron death") + path(MESH:"Plaque, Amyloid") positiveCorrelation p(HGNC:SYK, pmod(go:0006468 ! "protein phosphorylation")) - pmid:25681350 + pubmed:24401760 - a(PUBCHEM:14235) increases r(MGI:"chitinase-like 1") + path(MESH:"Plaque, Amyloid") positiveCorrelation p(HGNC:ITPKB) - pmid:25681350 + pubmed:30988501 - a(PUBCHEM:14235) increases r(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") + path(MESH:"Plaque, Amyloid") association a(MESH:"Herpesvirus 1, Human") - pmid:25681350 + pubmed:30663117 - r(MGI:"chitinase-like 1") positiveCorrelation r(MGI:"interleukin 1 alpha") + g(HGNC:MIR124-1) decreases p(HGNC:BACE1) - - - pmid:25681350 - - r(MGI:"chitinase-like 1") positiveCorrelation r(MGI:"interleukin 6") - + - - - pmid:25681350 - - r(MGI:"interleukin 1 alpha") positiveCorrelation r(MGI:"chitinase-like 1") - + - pmid:25681350 + pubmed:10656250 - r(MGI:"interleukin 6") positiveCorrelation r(MGI:"chitinase-like 1") + p(HGNC:BACE1) increases tloc(p(CONSO:sAPP-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:25681350 + pubmed:24590577 - p(MGI:"myelin oligodendrocyte glycoprotein", frag("35_50")) increases r(MGI:"chitinase-like 1") + p(HGNC:BACE1) increases p(CONSO:sAPP-beta) - - - pmid:25681350 - - p(MGI:"myelin oligodendrocyte glycoprotein", frag("35_50")) increases r(MGI:"interleukin 1 alpha") - + - pmid:25681350 + pubmed:10656250 - p(MGI:"myelin oligodendrocyte glycoprotein", frag("35_50")) increases r(MGI:"interleukin 6") + p(HGNC:BACE1) causesNoChange tloc(p(CONSO:sAPP-alpha), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - - - pmid:25681350 + pubmed:10656250 - p(MGI:"interleukin 1 alpha") increases complex(GO:"NF-kappaB complex") + p(HGNC:BACE1) causesNoChange p(HGNC:APP) - pmid:25681350 + pubmed:10656250 - p(MGI:"interleukin 1 alpha") increases p(MGI:"signal transducer and activator of transcription 3") + p(HGNC:BACE1, loc(GO:"endoplasmic reticulum")) association p(HGNC:APP, loc(GO:"endoplasmic reticulum")) - pmid:25681350 + pubmed:24590577 - p(MGI:"interleukin 1 alpha") increases act(p(MGI:"signal transducer and activator of transcription 3")) + p(HGNC:BACE1) increases deg(p(HGNC:APP)) - pmid:25681350 + pubmed:21718217 - p(MGI:"interleukin 1 alpha") increases r(MGI:"chitinase-like 1") + p(HGNC:BACE1) decreases p(HGNC:APP) - pmid:25681350 + pubmed:10656250 - p(MGI:"interleukin 1 alpha") increases r(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") + p(HGNC:BACE1) increases p(HGNC:APP, frag("672_770")) - pmid:25681350 + pubmed:10656250 - p(MGI:"interleukin 1 alpha") increases act(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B")) + p(HGNC:BACE1) association p(CONSO:APP695) - pmid:25681350 + pubmed:10656250 - p(MGI:"interleukin 1 alpha") increases act(complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105"))) + p(HGNC:BACE1) association p(CONSO:APP751) - pmid:25681350 + pubmed:30444369 - p(MGI:"interleukin 1 alpha") increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) + p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta polypeptide 42"), p(CONSO:"APP C-terminally truncated carboxyl-terminal fragments"))) - pmid:25681350 + pubmed:18650430 - act(p(MGI:"interleukin 1 alpha")) increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) + act(p(HGNC:BACE1), ma(go:0008233 ! "peptidase activity")) increases rxn(reactants(p(HGNC:APP)), products(p(HGNC:APP, frag("11_*")), p(HGNC:APP, frag("1_10")))) - - - pmid:25681350 - - p(MGI:"interleukin 1 alpha") increases path(MESH:Glioblastoma) - + - - - pmid:25681350 - - p(MGI:"interleukin 1 alpha") increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"chitinase-like 1"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) - + - pmid:25681350 + pubmed:21214928 - p(MGI:"interleukin 1 alpha") regulates p(MGI:"chitinase-like 1") + p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:amyloid-beta))) - pmid:25681350 + pubmed:21214928 - p(MGI:"interleukin 1 alpha") increases p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105") + p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:amyloid-beta))) - pmid:28745240 + pubmed:21214928 - complex(GO:"NF-kappaB complex") increases bp(MESH:"Synaptic Transmission") + p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:amyloid-beta))) - pmid:28745240 + pubmed:22122372 - complex(GO:"NF-kappaB complex") increases bp(MESH:"Synaptic Transmission") + p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:amyloid-beta))) - pmid:25652642 + pubmed:21722302 - act(complex(GO:"NF-kappaB complex")) increases bp(MESH:"Synaptic Transmission") + p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:amyloid-beta))) + + + + - pmid:28745240 + pubmed:21214928 - act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"neuron death") + p(HGNC:BACE1) increases bp(GO:"neuron death") - pmid:28745240 + pubmed:21214928 - complex(GO:"NF-kappaB complex") decreases bp(GO:"neuron death") + p(HGNC:BACE1) decreases bp(GO:"synaptic transmission, cholinergic") - pmid:28745240 + pubmed:21214928 - complex(GO:"NF-kappaB complex") decreases bp(GO:"neuron death") + p(HGNC:BACE1) decreases bp(GO:memory) - pmid:28745240 + pubmed:21214928 - act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"neuron death") + p(HGNC:BACE1) increases p(HGNC:APP, frag("672_713")) - pmid:25652642 + pubmed:21214928 - act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"neuron death") + p(HGNC:BACE1) increases p(HGNC:APP, frag("672_711")) - pmid:28745240 + pubmed:22122372 - complex(GO:"NF-kappaB complex") increases bp(GO:"positive regulation of synaptic plasticity") + p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(p(CONSO:CONSO00042), p(CONSO:CONSO00081))) - pmid:25652642 + pubmed:22122372 - act(complex(GO:"NF-kappaB complex")) increases bp(GO:"positive regulation of synaptic plasticity") + p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(p(CONSO:CONSO00042), p(CONSO:CONSO00081))) - pmid:28745240 + pubmed:22122372 - complex(GO:"NF-kappaB complex") regulates bp(GO:cognition) + p(HGNC:BACE1) increases a(CHEBI:amyloid-beta) - pmid:28745240 + pubmed:18986241 - complex(GO:"NF-kappaB complex") regulates bp(GO:behavior) + act(p(HGNC:BACE1)) increases a(CHEBI:amyloid-beta) - pmid:28745240 + pubmed:25331948 - complex(GO:"NF-kappaB complex") increases path(MESH:"Spatial Memory") + p(HGNC:BACE1) increases a(CHEBI:amyloid-beta) - pmid:25652642 + pubmed:26195256 - act(complex(GO:"NF-kappaB complex")) increases path(MESH:"Spatial Memory") + act(p(HGNC:BACE1)) increases a(CHEBI:amyloid-beta) - pmid:28745240 + pubmed:29626319 - complex(GO:"NF-kappaB complex") increases bp(GO:memory) + p(HGNC:BACE1) increases a(CHEBI:amyloid-beta) - pmid:28745240 + pubmed:19126755 - complex(GO:"NF-kappaB complex") increases bp(GO:learning) + p(HGNC:BACE1) increases a(CHEBI:"amyloid-beta polypeptide 42") + + + + - pmid:28745240 + pubmed:24590577 - complex(GO:"NF-kappaB complex") increases act(p(HGNC:PRKACA)) + p(HGNC:BACE1) increases p(CONSO:C99) + + - pmid:28745240 + pubmed:21718217 - complex(GO:"NF-kappaB complex") decreases p(HGNC:BCL2L1) + p(HGNC:BACE1) increases a(CHEBI:"amyloid-beta polypeptide 40") - pmid:28745240 + pubmed:23516100 - complex(GO:"NF-kappaB complex") increases p(HGNC:BCL2L1) + p(HGNC:BACE1) association act(p(HGNCGENEFAMILY:Calpains)) - pmid:28745240 + pubmed:23516100 - complex(GO:"NF-kappaB complex") increases p(HGNC:BCL2L1) + act(p(HGNC:BACE1)) increases p(HGNC:APP, frag("?")) - pmid:28745240 + pubmed:23516100 - complex(GO:"NF-kappaB complex") decreases sec(a(PUBCHEM:16057918)) + act(p(HGNC:BACE1)) increases p(HGNC:APP, frag("?"), loc(GO:"secretory vesicle")) - pmid:28745240 + pubmed:29758300 - complex(GO:"NF-kappaB complex") decreases bp(GO:"apoptotic process") + p(HGNC:BACE1) increases p(HGNC:APP, frag("?")) - pmid:28745240 + pubmed:14556719 - complex(GO:"NF-kappaB complex") decreases bp(GO:"apoptotic process") + p(HGNC:BACE1) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta polypeptide 40"), a(CHEBI:"amyloid-beta polypeptide 42"))) - pmid:25652642 + pubmed:30663117 - act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"apoptotic process") + complex(g(HGNC:MIR124-1), r(HGNC:BACE1)) decreases act(r(HGNC:BACE1)) - pmid:25652642 + pubmed:30663117 - act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"apoptotic process") + complex(g(HGNC:MIR15B), r(HGNC:BACE1)) decreases p(HGNC:BACE1) + + - pmid:28745240 + pubmed:30663117 - complex(GO:"NF-kappaB complex") increases p(HGNC:BCL2) + complex(g(HGNC:MIR339), r(HGNC:BACE1)) decreases p(HGNC:BACE1) + + - pmid:28745240 + pubmed:30663117 - complex(GO:"NF-kappaB complex") increases p(HGNC:BCL2A1) + complex(g(HGNC:MIR384), r(HGNC:BACE1)) decreases p(HGNC:BACE1) + + + + - pmid:28745240 + pubmed:30663117 - act(complex(GO:"NF-kappaB complex")) decreases act(a(MESH:"Amyloid beta-Peptides")) + g(HGNC:MIR384) association path(MESH:"Alzheimer Disease") - pmid:28745240 + pubmed:30663117 - act(complex(GO:"NF-kappaB complex")) increases p(HGNC:SOD2) + complex(g(HGNC:MIR384), r(HGNC:APP)) decreases p(HGNC:APP) + + - pmid:28745240 + pubmed:24107444 - act(complex(GO:"NF-kappaB complex")) increases p(HGNC:SOD2) + p(HGNC:APP) association complex(GO:"gamma-secretase complex") - pmid:25652642 + pubmed:24883238 - act(complex(GO:"NF-kappaB complex")) increases act(p(HGNC:SOD2)) + p(HGNC:APP) association p(HGNC:STK11) - pmid:28745240 + pubmed:24883238 - act(complex(GO:"NF-kappaB complex")) decreases p(MESH:Proteins, pmod(HBP:nitration)) + p(HGNC:APP) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:28745240 + pubmed:17234589 - act(complex(GO:"NF-kappaB complex")) increases bp(GO:neurogenesis) + p(HGNC:APP) association p(FB:Lkb1) + + - pmid:28745240 + pubmed:31346362 - act(complex(GO:"NF-kappaB complex")) increases bp(GO:neurogenesis) + p(HGNC:APP) increases path(DOID:"Alzheimer's disease") - pmid:28745240 + pubmed:30232325 - act(complex(GO:"NF-kappaB complex")) increases bp(GO:neurogenesis) + p(HGNC:APP) increases act(p(HGNC:WNT3A)) - pmid:28745240 + pubmed:30232325 - complex(GO:"NF-kappaB complex") regulates a(MESH:"Neural Stem Cells") + p(HGNC:APP) increases act(p(HGNC:WNT5A)) + + + + + + + + - pmid:28745240 + pubmed:30232325 - act(complex(GO:"NF-kappaB complex")) negativeCorrelation a(MESH:"Cerebral Cortex") + p(HGNC:APP) increases bp(GO:"canonical Wnt signaling pathway") - pmid:28745240 + pubmed:30232325 - act(complex(GO:"NF-kappaB complex")) increases bp(GO:"stem cell division") + p(HGNC:APP) increases bp(GO:"non-canonical Wnt signaling pathway") + + - pmid:28745240 + pubmed:11230871 - complex(GO:"NF-kappaB complex") increases p(HGNC:IL6) + act(p(HGNC:APP)) association p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) - pmid:28745240 + pubmed:30232325 - complex(GO:"NF-kappaB complex") increases p(HGNC:IL6) + p(HGNC:APP) increases act(p(HGNC:DKK1)) - pmid:28745240 + pubmed:30232325 - complex(GO:"NF-kappaB complex") increases p(HGNC:IL6) + p(HGNC:APP) increases act(p(HGNC:DKK1)) - pmid:28745240 + pubmed:30232325 - complex(GO:"NF-kappaB complex") increases p(HGNC:IL6) + p(HGNC:APP) increases path(CONSO:CONSO00061) + + + + - pmid:25652642 + pubmed:10656250 - complex(GO:"NF-kappaB complex") increases p(HGNC:IL6) + p(HGNC:APP, loc(GO:"endoplasmic reticulum")) association p(HGNC:BACE1, loc(GO:"endoplasmic reticulum")) - pmid:28745240 + pubmed:21034527 - act(complex(GO:"NF-kappaB complex")) increases bp(GO:"astrocyte development") + p(HGNC:APP) regulates p(HGNC:BACE1) - pmid:28745240 + pubmed:21034527 - complex(GO:"NF-kappaB complex") increases p(HGNC:LIF) + act(p(HGNC:APP), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases act(p(HGNC:BACE1)) + + + + + + + + + + + + + + - pmid:28745240 + pubmed:18650430 - complex(GO:"NF-kappaB complex") increases p(HGNC:CNTF) + p(HGNC:APP) increases bp(GO:"regulation of cell growth") - pmid:28745240 + pubmed:18650430 - act(complex(GO:"NF-kappaB complex")) increases bp(GO:"dendritic spine organization") + p(HGNC:APP) increases bp(GO:"synapse assembly") - pmid:28745240 + pubmed:21214928 - act(complex(GO:"NF-kappaB complex")) increases bp(MESH:"Neuronal Outgrowth") + p(HGNC:APP) association bp(GO:"synapse assembly") - pmid:28745240 + pubmed:18650430 - act(complex(GO:"NF-kappaB complex")) increases bp(MESH:"Neuronal Outgrowth") + p(HGNC:APP) increases bp(MESH:"Neuronal Outgrowth") - pmid:28745240 + pubmed:21214928 - act(complex(GO:"NF-kappaB complex")) increases bp(MESH:"Neuronal Outgrowth") + p(HGNC:APP) association bp(MESH:"Neuronal Outgrowth") - pmid:28745240 + pubmed:18650430 - act(complex(GO:"NF-kappaB complex")) increases bp(MESH:"Neuronal Outgrowth") + p(HGNC:APP) increases bp(GO:"cell adhesion") - pmid:28745240 + pubmed:21214928 - act(complex(GO:"NF-kappaB complex")) increases a(GO:axon) + p(HGNC:APP) association bp(GO:"cell adhesion") - pmid:28745240 + pubmed:22122372 - act(complex(GO:"NF-kappaB complex")) increases bp(GO:"axon guidance") + p(HGNC:APP) increases bp(GO:"cell adhesion") + + - pmid:28745240 + pubmed:18650430 - complex(GO:"NF-kappaB complex") increases p(HGNC:ITGB1) + p(HGNC:APP) regulates act(p(HGNC:SLC5A7)) - pmid:28745240 + pubmed:21214928 - complex(GO:"NF-kappaB complex") regulates p(HGNC:NCAM1) + p(HGNC:APP) increases a(CHEBI:amyloid-beta) - pmid:28745240 + pubmed:22122372 - complex(GO:"NF-kappaB complex") regulates p(HGNC:SLITRK1) + p(HGNC:APP) increases a(CHEBI:amyloid-beta) - pmid:28745240 + pubmed:26027813 - complex(GO:"NF-kappaB complex") regulates p(HGNC:GFRA1) + p(HGNC:APP) increases a(CHEBI:amyloid-beta) - pmid:28745240 + pubmed:21722302 - complex(GO:"NF-kappaB complex") regulates p(HGNC:TIAM1) + p(HGNC:APP) increases a(CHEBI:amyloid-beta) - pmid:28745240 + pubmed:18930136 - act(complex(GO:"NF-kappaB complex")) increases a(MESH:"Dendritic Cells") + deg(p(HGNC:APP)) association a(CHEBI:amyloid-beta) - pmid:28745240 + pubmed:21214928 - act(complex(GO:"NF-kappaB complex")) increases a(GO:"dendritic branch") + p(HGNC:APP) association bp(GO:"signal transduction") - pmid:28745240 + pubmed:21214928 - act(complex(GO:"NF-kappaB complex")) increases p(HGNC:HES1) + p(HGNC:APP) association bp(GO:"calcium ion homeostasis") - pmid:28745240 + pubmed:21214928 - act(complex(GO:"NF-kappaB complex")) increases p(HGNC:HES5) + p(HGNC:APP) association bp(GO:"protein transport") - pmid:28745240 + pubmed:21214928 - complex(GO:"NF-kappaB complex") increases p(HGNC:MAP1B) + p(HGNC:APP) regulates bp(GO:"protein transport") - - - pmid:28745240 - - complex(GO:"NF-kappaB complex") increases p(HGNC:MAP2) - - - - - pmid:28745240 - - complex(GO:"NF-kappaB complex") regulates p(HGNC:C3) - - - - - pmid:28745240 - - complex(GO:"NF-kappaB complex") regulates p(HGNC:CFB) - - - pmid:28745240 + pubmed:21214928 - complex(GO:"NF-kappaB complex") regulates p(HGNC:CR2) + p(HGNC:APP) association p(HGNC:ITGB1) - pmid:28745240 + pubmed:21214928 - complex(GO:"NF-kappaB complex") regulates p(HGNC:C4A) + p(HGNC:APP) association bp(GO:"anterograde axonal protein transport") - - - pmid:28745240 - - complex(GO:"NF-kappaB complex") regulates p(HGNC:C4BPA) - - - - - pmid:28745240 - - complex(GO:"NF-kappaB complex") regulates p(HGNC:IL1B) - - - - - pmid:28745240 - - complex(GO:"NF-kappaB complex") increases p(HGNC:IL1B) - - - - - pmid:25652642 - - complex(GO:"NF-kappaB complex") increases p(HGNC:IL1B) - - - pmid:28745240 + pubmed:21156028 - complex(GO:"NF-kappaB complex") increases act(p(HGNC:IL1A)) + deg(p(HGNC:APP)) increases p(HGNC:APP, frag("672_713")) - pmid:28745240 + pubmed:26996954 - complex(GO:"NF-kappaB complex") increases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) + p(HGNC:APP) decreases p(HGNC:APP, frag("672_713")) - - - pmid:28745240 - - complex(GO:"NF-kappaB complex") increases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) - - - pmid:28745240 + pubmed:21156028 - complex(GO:"NF-kappaB complex") increases act(complex(p(HGNC:CDK5), p(HGNC:CDK5R1))) + deg(p(HGNC:APP)) increases p(HGNC:APP, frag("672_711")) - - - pmid:28745240 - - complex(GO:"NF-kappaB complex") regulates p(HGNC:TNF) - - - - - pmid:28745240 - - complex(GO:"NF-kappaB complex") increases p(HGNC:TNF) - - - - - pmid:28745240 - - complex(GO:"NF-kappaB complex") increases p(HGNC:TNF) - - - - - pmid:25652642 - - complex(GO:"NF-kappaB complex") increases p(HGNC:TNF) - - - - - pmid:28745240 - - act(complex(GO:"NF-kappaB complex")) increases sec(a(CHEBI:"amyloid-beta")) - + - - - pmid:28745240 - - act(complex(GO:"NF-kappaB complex")) increases a(CHEBI:"amyloid-beta") - + - - - pmid:28745240 - - complex(GO:"NF-kappaB complex") regulates a(CHEBI:"amyloid-beta") - + - pmid:28745240 + pubmed:22122372 - complex(GO:"NF-kappaB complex") regulates a(CHEBI:"amyloid-beta") + p(HGNC:APP) increases a(MESH:"Amyloid beta-Peptides") - pmid:25652642 + pubmed:29758300 - act(complex(GO:"NF-kappaB complex")) regulates a(CHEBI:"amyloid-beta") + p(HGNC:APP) increases a(MESH:"Amyloid beta-Peptides") - pmid:25652642 + pubmed:14556719 - act(complex(GO:"NF-kappaB complex")) positiveCorrelation a(CHEBI:"amyloid-beta") + p(HGNC:APP) increases a(MESH:"Amyloid beta-Peptides") - pmid:28745240 + pubmed:22122372 - complex(GO:"NF-kappaB complex") increases p(HGNC:BACE1) + p(HGNC:APP) association p(CONSO:CONSO00078) - pmid:28745240 + pubmed:22122372 - complex(GO:"NF-kappaB complex") increases p(HGNC:BACE1) + p(HGNC:APP) association p(CONSO:CONSO00079) - - - pmid:25652642 - - act(complex(GO:"NF-kappaB complex")) regulates p(HGNC:BACE1) - - - - - pmid:25652642 - - act(complex(GO:"NF-kappaB complex")) decreases p(HGNC:BACE1) - + - pmid:21958873 + pubmed:22122372 - complex(GO:"NF-kappaB complex") regulates p(HGNC:BACE1) + p(HGNC:APP) association a(MESH:"Receptors, Cell Surface") - - - pmid:25331948 - - complex(GO:"NF-kappaB complex") regulates p(HGNC:BACE1) - - - - - pmid:28745240 - - complex(GO:"NF-kappaB complex") regulates bp(HBP:"APP processing") - + - - - pmid:25652642 - - act(complex(GO:"NF-kappaB complex")) decreases bp(HBP:"APP processing") - + - pmid:25652642 + pubmed:21034527 - act(complex(GO:"NF-kappaB complex")) positiveCorrelation bp(HBP:"APP processing") + p(HGNC:APP) regulates p(HGNC:APP) - pmid:28745240 + pubmed:21034527 - complex(GO:"NF-kappaB complex") regulates p(HBP:C99) + act(p(HGNC:APP), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases act(p(HGNC:APP)) - pmid:28745240 + pubmed:21034527 - complex(GO:"NF-kappaB complex") regulates act(complex(GO:"gamma-secretase complex")) + p(HGNC:APP) regulates p(HGNC:KAT5) - pmid:28745240 + pubmed:21034527 - complex(GO:"NF-kappaB complex") increases act(complex(GO:"gamma-secretase complex")) + act(p(HGNC:APP), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases act(p(HGNC:KAT5)) - pmid:28745240 + pubmed:21034527 - complex(GO:"NF-kappaB complex") regulates p(HGNC:PSEN1) + p(HGNC:APP) regulates p(HGNC:GSK3B) - pmid:28745240 + pubmed:21034527 - complex(GO:"NF-kappaB complex") regulates p(HGNC:APP) + act(p(HGNC:APP)) increases act(p(HGNC:GSK3B)) - pmid:28745240 + pubmed:26968346 - complex(GO:"NF-kappaB complex") regulates p(HGNC:APP) + deg(p(HGNC:APP)) decreases p(HGNC:GSK3B) - pmid:25652642 + pubmed:21034527 - act(complex(GO:"NF-kappaB complex")) regulates p(HGNC:APP) + p(HGNC:APP) regulates p(HGNC:TP53) - pmid:28745240 + pubmed:21034527 - act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"calcium ion homeostasis") + act(p(HGNC:APP), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases act(p(HGNC:TP53)) - pmid:28745240 + pubmed:21034527 - complex(GO:"NF-kappaB complex") increases p(HGNC:CXCL8) + p(HGNC:APP) regulates p(HGNC:SOD2) - pmid:25652642 + pubmed:21034527 - act(complex(GO:"NF-kappaB complex")) increases bp(GO:"inflammatory response") + act(p(HGNC:APP), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases act(p(HGNC:SOD2)) - pmid:25652642 + pubmed:21034527 - act(complex(GO:"NF-kappaB complex")) increases a(MESH:"Free Radicals") + p(HGNC:APP) regulates p(HGNC:CD82) - pmid:25652642 + pubmed:21034527 - act(complex(GO:"NF-kappaB complex")) positiveCorrelation a(GO:"neurofibrillary tangle") + act(p(HGNC:APP), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases act(p(HGNC:CD82)) - pmid:25652642 + pubmed:21034527 - act(complex(GO:"NF-kappaB complex")) positiveCorrelation path(MESH:"Plaque, Amyloid") + p(HGNC:APP) regulates p(HGNC:MME) - pmid:25652642 + pubmed:21034527 - complex(GO:"NF-kappaB complex") association path(MESH:"Plaque, Amyloid") + p(HGNC:APP) regulates p(HGNC:TAGLN) - pmid:25652642 + pubmed:21034527 - act(complex(GO:"NF-kappaB complex")) decreases p(HBP:"sAPP-beta") + act(p(HGNC:APP), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases act(p(HGNC:TAGLN)) - pmid:25652642 + pubmed:21034527 - act(complex(GO:"NF-kappaB complex")) positiveCorrelation p(HBP:"sAPP-beta") + p(HGNC:APP) regulates p(HGNC:ACTA2) - pmid:25652642 + pubmed:21034527 - complex(GO:"NF-kappaB complex") association act(p(HGNC:APOE)) + act(p(HGNC:APP), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases act(p(HGNC:ACTA2)) - pmid:25652642 + pubmed:21034527 - complex(GO:"NF-kappaB complex") increases bp(MESH:Neuroprotection) + p(HGNC:APP) regulates p(HGNC:S100A9) - pmid:25652642 + pubmed:21034527 - complex(GO:"NF-kappaB complex") regulates bp(MESH:Neuroprotection) + act(p(HGNC:APP), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases act(p(HGNC:S100A9)) - - - pmid:25652642 - - act(complex(GO:"NF-kappaB complex")) decreases a(CHEBI:peroxynitrite) - - - pmid:25652642 + pubmed:22110360 - act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"membrane depolarization") + p(HGNC:APP) association p(HGNC:DYRK1A) - pmid:25652642 + pubmed:21034527 - act(complex(GO:"NF-kappaB complex")) decreases a(MESH:"Cholinergic Neurons") + act(p(HGNC:APP), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) association p(INTERPRO:"Amyloidogenic glycoprotein, intracellular domain, conserved site") - pmid:25652642 + pubmed:21034527 - act(complex(GO:"NF-kappaB complex")) positiveCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNC:APP), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases act(p(HGNC:BACE2)) - pmid:25652642 + pubmed:21034527 - complex(GO:"NF-kappaB complex") positiveCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNC:APP), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases act(p(HGNC:MMEL1)) - pmid:25652642 + pubmed:19926167 - complex(GO:"NF-kappaB complex") positiveCorrelation path(MESH:"Alzheimer Disease") + deg(p(HGNC:APP)) association p(HGNC:CTSD) - pmid:25652642 + pubmed:25570489 - act(complex(GO:"NF-kappaB complex")) increases act(a(MESH:Microglia)) + p(HGNC:APP) association a(NIFT:"Cerebral atrophy") - pmid:25652642 + pubmed:20100581 - act(complex(GO:"NF-kappaB complex")) increases act(a(MESH:Cytokines)) + p(HGNC:APP) association bp(HP:Neurodegeneration) - pmid:25652642 + pubmed:25678559 - act(complex(GO:"NF-kappaB complex")) increases act(a(CHEBI:"glutamate(1-)")) + p(HGNC:APP) increases a(NIFT:"Hippocampal Formation") - pmid:25652642 + pubmed:25678559 - act(complex(GO:"NF-kappaB complex")) increases act(a(CHEBI:"reactive oxygen species")) + p(HGNC:APP) negativeCorrelation a(NIFT:"Hippocampus volume") - pmid:25652642 + pubmed:25678559 - act(complex(GO:"NF-kappaB complex")) increases act(a(CHEBI:"reactive oxygen species")) + p(HGNC:APP) negativeCorrelation a(NIFT:"Mini mental state exam") - pmid:25652642 + pubmed:25678559 - act(complex(GO:"NF-kappaB complex")) increases act(p(HGNC:NOS2)) + p(HGNC:APP) positiveCorrelation a(NIFT:"Clinical dementia rating") - pmid:25652642 + pubmed:20065247 - act(complex(GO:"NF-kappaB complex")) increases act(p(HGNC:NOS2)) + p(HGNC:APP) positiveCorrelation a(NIFT:"Hippocampal atrophy") - pmid:25652642 + pubmed:26996954 - act(complex(GO:"NF-kappaB complex")) increases path(HBP:neurotoxicity) + p(HGNC:APP) association p(HGNC:SORL1) - - - pmid:25652642 - - complex(GO:"NF-kappaB complex") regulates m(HGNC:"MIR9-1") - + - - - pmid:25652642 - - complex(GO:"NF-kappaB complex") regulates m(HGNC:MIR34A) - + - pmid:25652642 + pubmed:31248781 - complex(GO:"NF-kappaB complex") regulates m(HGNC:MIR125B1) + p(HGNC:APP) regulates bp(MESH:Neuroprotection) - - - pmid:25652642 - - complex(GO:"NF-kappaB complex") regulates m(HGNC:MIR146A) - - - - - pmid:25652642 - - complex(GO:"NF-kappaB complex") regulates m(HGNC:MIR155) - + - - - pmid:25652642 - - complex(GO:"NF-kappaB complex") regulates m(HGNC:MIR339) - + - - - pmid:21958873 - - complex(GO:"NF-kappaB complex") regulates p(HGNC:CRP) - + - - - pmid:25331948 - - complex(GO:"NF-kappaB complex") regulates r(HGNC:BACE1) - + - pmid:25681350 + pubmed:12428809 - p(MGI:"signal transducer and activator of transcription 3") association p(MGI:"chitinase-like 1") + p(HGNC:APP) association bp(GO:"axonal transport") - - - pmid:25681350 - - p(MGI:"signal transducer and activator of transcription 3") increases p(MGI:"chitinase-like 1") - - - pmid:25681350 + pubmed:12428809 - p(MGI:"signal transducer and activator of transcription 3") increases r(MGI:"chitinase-like 1") + tloc(p(HGNC:APP), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association bp(GO:"regulation of neuronal synaptic plasticity") - pmid:25681350 + pubmed:12428809 - act(p(MGI:"signal transducer and activator of transcription 3")) increases act(p(MGI:"interleukin 1 alpha")) + tloc(p(HGNC:APP), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association bp(GO:"negative regulation of neuron apoptotic process") - - - pmid:25681350 - - act(p(MGI:"signal transducer and activator of transcription 3")) increases act(p(MGI:"oncostatin M")) - - - pmid:25681350 + pubmed:26968346 - p(MGI:"oncostatin M") increases complex(GO:"NF-kappaB complex") + deg(p(HGNC:APP)) increases p(HGNC:TFEB, loc(GO:nucleus)) - pmid:25681350 + pubmed:26968346 - p(MGI:"oncostatin M") increases p(MGI:"signal transducer and activator of transcription 3") + deg(p(HGNC:APP)) increases act(p(HGNC:TFEB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) - pmid:25681350 + pubmed:22908190 - p(MGI:"oncostatin M") increases act(p(MGI:"signal transducer and activator of transcription 3")) + p(HGNC:APP) positiveCorrelation p(CONSO:"APP C-terminally truncated carboxyl-terminal fragments") - pmid:25681350 + pubmed:22908190 - p(MGI:"oncostatin M") increases act(p(MGI:"signal transducer and activator of transcription 3")) + p(HGNC:APP) positiveCorrelation bp(GO:endocytosis) - pmid:25681350 + pubmed:22908190 - p(MGI:"oncostatin M") increases r(MGI:"chitinase-like 1") + p(HGNC:APP) increases a(GO:endosome) - pmid:25681350 + pubmed:22908190 - p(MGI:"oncostatin M") increases path(MESH:Glioblastoma) + p(HGNC:APP) association a(GO:autophagosome) - - - pmid:25681350 - - p(MGI:"oncostatin M") regulates p(MGI:"chitinase-like 1") - + - pmid:25681350 + pubmed:26631930 - p(MGI:"oncostatin M") increases p(MGI:"chitinase-like 1") + tloc(p(HGNC:APP), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) increases complex(p(HGNC:APP), p(HGNC:SLC40A1)) - - - pmid:25681350 - - p(MGI:"oncostatin M") increases complex(p(MGI:"chitinase-like 1"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) - + - - - pmid:25681350 - - p(MGI:"oncostatin M") increases act(p(MGI:"interleukin 1 alpha")) - + - - - pmid:25681350 - - p(MGI:"oncostatin M") increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) - + - - - pmid:25681350 - - p(MGI:"v-rel reticuloendotheliosis viral oncogene homolog A (avian)") association p(MGI:"chitinase-like 1") - + - pmid:25681350 + pubmed:28669544 - p(MGI:"v-rel reticuloendotheliosis viral oncogene homolog A (avian)") association p(MGI:"chitinase-like 1") + p(HGNC:APP) increases a(MESH:Microglia) - pmid:25681350 + pubmed:28669544 - p(MGI:"v-rel reticuloendotheliosis viral oncogene homolog A (avian)") association p(MGI:"chitinase-like 1") + deg(p(HGNC:APP)) directlyDecreases p(HGNC:DLG4) - pmid:25681350 + pubmed:28669544 - p(MGI:"v-rel reticuloendotheliosis viral oncogene homolog A (avian)") decreases p(MGI:"chemokine (C-X-C motif) ligand 15") + deg(p(HGNC:APP)) causesNoChange p(HGNC:MAP2) - pmid:25681350 + pubmed:28669544 - p(MGI:"chitinase-like 1") association p(MGI:"v-rel reticuloendotheliosis viral oncogene homolog A (avian)") + deg(p(HGNC:APP)) decreases p(HGNCGENEFAMILY:Synapsins) - pmid:25681350 + pubmed:28669544 - p(MGI:"chitinase-like 1") association p(MGI:"v-rel reticuloendotheliosis viral oncogene homolog A (avian)") + deg(p(HGNC:APP)) decreases p(HGNCGENEFAMILY:Synaptophysins) - pmid:25681350 + pubmed:28669544 - p(MGI:"chitinase-like 1") association p(MGI:"v-rel reticuloendotheliosis viral oncogene homolog A (avian)") + deg(p(HGNC:APP)) decreases bp(GO:"synaptic transmission, glutamatergic") - - - pmid:25681350 - - p(MGI:"chitinase-like 1") association p(MGI:"signal transducer and activator of transcription 3") - - - pmid:25681350 + pubmed:30663117 - p(MGI:"chitinase-like 1") association p(MGI:"reticuloendotheliosis oncogene") + complex(g(HGNC:MIR153-1), r(HGNC:BACE1)) decreases p(HGNC:APP) - - - pmid:25681350 - - p(MGI:"chitinase-like 1") association p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100") - - - pmid:25681350 + pubmed:30663117 - p(MGI:"chitinase-like 1") increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"chitinase-like 1"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) + g(HGNC:MIR153-1) decreases p(HGNC:APP) - pmid:25681350 + pubmed:30663117 - p(MGI:"chitinase-like 1") increases complex(a(GO:"NF-kappaB p50/p65 complex"), p(MGI:"chitinase-like 1")) + g(HGNC:MIR153-1) decreases a(CHEBI:amyloid-beta) - pmid:25681350 + pubmed:30663117 - p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha", var("?")) decreases act(p(MGI:"interleukin 1 alpha")) + g(HGNC:MIR153-1) association path(MESH:"Alzheimer Disease") - pmid:25681350 + pubmed:30663117 - p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha", var("?")) decreases act(p(MGI:"oncostatin M")) + g(HGNC:MIR153-1) regulates p(HGNC:SNCA) - - - pmid:25681350 + pubmed:30663117 - p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") increases r(MGI:"chitinase-like 1") + g(HGNC:MIR153-1) regulates p(HGNC:SNCA) - - - pmid:25681350 - - p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") regulates p(MGI:"chitinase-like 1") - - - pmid:25681350 + pubmed:30663117 - p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") regulates p(MGI:"chitinase-like 1") + g(HGNC:MIR153-1) decreases path(MESH:"Parkinson Disease") - pmid:25681350 + pubmed:30663117 - p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") increases p(MGI:"chitinase-like 1") + p(HGNC:RANBP9) increases p(HGNC:APP) - pmid:25681350 + pubmed:30663117 - p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") increases act(p(MGI:"interleukin 1 alpha")) + g(HGNC:MIR101-1) decreases p(HGNC:APP) - pmid:25681350 + pubmed:30663117 - p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") increases act(p(MGI:"oncostatin M")) + g(HGNC:MIR101-1) decreases act(p(HGNC:APP)) - pmid:25681350 + pubmed:30663117 - p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105") increases r(MGI:"chitinase-like 1") + g(HGNC:MIR101-1) decreases act(p(HGNC:RANBP9)) - pmid:25681350 + pubmed:30663117 - p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105") regulates p(MGI:"chitinase-like 1") + g(HGNC:MIR101-1) association path(MESH:"Alzheimer Disease") - pmid:25681350 + pubmed:30663117 - p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105") increases act(p(MGI:"interleukin 1 alpha")) + g(HGNC:MIR101-1) decreases path(MESH:"Alzheimer Disease") - pmid:25681350 + pubmed:30663117 - p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105") increases act(p(MGI:"oncostatin M")) + act(p(HGNC:CAMKK2), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:25681350 + pubmed:30663117 - p(MGI:"reticuloendotheliosis oncogene") association p(MGI:"chitinase-like 1") + act(p(HGNC:CAMKK2), ma(go:0016301 ! "kinase activity")) increases act(a(CHEBI:amyloid-beta)) - - - pmid:25681350 - - p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100") association p(MGI:"chitinase-like 1") - - - pmid:25681350 + pubmed:30116051 - p(HGNC:IL1A) increases p(HGNC:RELB) + p(HGNC:CAMKK2) increases act(p(HGNC:PSMC5)) - pmid:25681350 + pubmed:30663117 - p(HGNC:IL1A) causesNoChange r(HGNC:CHI3L1) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) increases a(GO:"neurofibrillary tangle") - pmid:25681350 + pubmed:21214928 - p(HGNC:IL1A) causesNoChange r(HGNC:RELB) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) increases a(GO:"neurofibrillary tangle") - pmid:28745240 + pubmed:21156028 - act(p(HGNC:IL1A)) increases bp(GO:"p38MAPK cascade") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) increases a(GO:"neurofibrillary tangle") - pmid:23702978 + pubmed:28420982 - p(HGNC:IL1A) increases act(p(HGNC:IL1R1)) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) increases a(GO:"neurofibrillary tangle") - pmid:23702978 + pubmed:24883238 - p(HGNC:IL1A) increases bp(GO:"inflammatory response") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) association p(HGNC:STK11) - pmid:25681350 + pubmed:28760828 - p(HGNC:RELB) causesNoChange p(HGNC:CHI3L1) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"), loc(CONSO:"KXGS motif")) regulates act(p(HGNC:MAPT)) - pmid:25681350 + pubmed:29661268 - p(MGI:"tumor necrosis factor") increases act(complex(GO:"NF-kappaB complex")) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"), loc(CONSO:"microtubule-binding region")) increases act(p(HGNC:MAPT), ma(GO:"acetyltransferase activity")) - pmid:25681350 + pubmed:24760868 - p(MGI:"tumor necrosis factor") increases act(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B")) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) association act(p(HGNC:MAPT)) - pmid:25681350 + pubmed:26195256 - p(MGI:"tumor necrosis factor") increases act(complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105"))) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) decreases deg(p(HGNC:MAPT)) - - - - - pmid:25681350 + pubmed:29661268 - complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) regulates p(MGI:"chitinase-like 1") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) decreases composite(a(MESH:Microtubules), p(HGNC:MAPT)) - pmid:25681350 + pubmed:29661268 - complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) increases p(MGI:"chitinase-like 1") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) increases p(CONSO:"Tau aggregates") - pmid:25681350 + pubmed:29661268 - complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"chitinase-like 1"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) increases bp(GO:"microtubule severing") - pmid:25681350 + pubmed:29661268 - complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"chitinase-like 1"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) - pmid:21718217 + pubmed:29661268 - r(HGNC:CHI3L1) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"), loc(CONSO:"KXGS motif")) negativeCorrelation p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) - pmid:25681350 + pubmed:14612456 - p(HGNC:OSM) causesNoChange r(HGNC:CHI3L1) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) - pmid:25681350 + pubmed:29661268 - p(HGNC:OSM) causesNoChange r(HGNC:RELB) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) regulates act(p(HGNC:STUB1)) - pmid:25681350 + pubmed:22122372 - p(HGNC:RELA) causesNoChange p(HGNC:CHI3L1) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) association bp(GO:"neurofibrillary tangle assembly") - pmid:21329555 + pubmed:25468261 - p(HGNC:RELA) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation a(CONSO:"CDR - Sum of Boxes") - pmid:25652642 + pubmed:22701578 - p(HGNC:RELA) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation a(NIFT:"Rey auditory verbal learning test") - pmid:21329555 + pubmed:25116835 - p(HGNC:RELA) increases r(HGNC:BACE1) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation p(HGNC:DYRK1A) - pmid:21329555 + pubmed:20869593 - p(HGNC:RELA) increases p(HGNC:BACE1) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) association path(MESH:"Alzheimer Disease") - pmid:21329555 + pubmed:24653673 - p(HGNC:RELA) increases p(HBP:C99) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:21329555 + pubmed:29758300 - p(HGNC:RELA) causesNoChange p(HGNC:APP) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) increases path(MESH:"Alzheimer Disease") - pmid:21329555 + pubmed:8282104 - p(HGNC:RELA) increases a(CHEBI:"amyloid-beta") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:28745240 + pubmed:29191965 - p(HGNC:RELA) increases bp(MESH:"Synaptic Transmission") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:28745240 + pubmed:29191965 - p(HGNC:RELA) increases bp(GO:"long-term synaptic potentiation") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:28745240 + pubmed:29311797 - p(HGNC:RELA) negativeCorrelation bp(GO:"apoptotic process") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) association path(MESH:"Alzheimer Disease") - pmid:27288790 + pubmed:26458742 - act(p(HGNC:RELA)) increases bp(GO:"apoptotic process") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation path(MESH:"Alzheimer Disease") - - - - - - - pmid:27288790 + pubmed:26631930 - p(HGNC:RELA) decreases bp(GO:"neuron apoptotic process") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:25681350 + pubmed:26631930 - p(HGNC:STAT3) causesNoChange p(HGNC:CHI3L1) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:28745240 + pubmed:20869593 - p(HGNC:STAT3) increases bp(GO:"astrocyte development") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) association path(MESH:"Parkinson Disease") - - - pmid:19293145 + pubmed:20869593 - act(p(HGNC:STAT3)) association p(HGNC:JAK2) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) association path(MESH:"Frontotemporal Dementia") - pmid:19293145 + pubmed:18583940 - act(p(HGNC:STAT3)) association act(a(CHEBI:nicotine)) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) decreases bp(GO:"microtubule cytoskeleton organization") - pmid:30116051 + pubmed:18583940 - p(HGNC:STAT3) decreases bp(GO:macroautophagy) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) increases path(MESH:"Neurodegenerative Diseases") - pmid:25681350 + pubmed:15601849 - path(MESH:Glioblastoma) increases p(MGI:"chitinase-like 1") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation bp(GO:"activation of MAPKK activity") - pmid:25681350 + pubmed:19419557 - path(MESH:Glioblastoma) increases p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) association bp(GO:"calcium-mediated signaling") - - - - - - - - - - - pmid:25681350 + pubmed:25024322 - composite(p(MGI:"interleukin 1 alpha"), p(MGI:"oncostatin M")) increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"chitinase-like 1"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation p(HGNC:CHI3L1) - - - - - - - - - - - - - pmid:21329555 + pubmed:25865441 - complex(g(HGNC:BACE1), p(FPLX:NFkappaB)) regulates r(HGNC:BACE1) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation p(HGNC:CHI3L1) - pmid:21329555 + pubmed:25865441 - act(p(FPLX:NFkappaB), ma(tscript)) increases r(HGNC:BACE1) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation p(HGNC:CHI3L1) - - - pmid:29179999 - - act(p(FPLX:NFkappaB)) association bp(GO:"inflammatory response") - - - pmid:29179999 + pubmed:30515821 - tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) increases bp(GO:"inflammatory response") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) increases path(NCIT:C27990) - pmid:27288790 + pubmed:19293145 - p(FPLX:NFkappaB) regulates bp(GO:"inflammatory response") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) association p(HGNC:FYN) - pmid:29179999 + pubmed:30697142 - p(FPLX:NFkappaB) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation bp(GO:cognition) - pmid:27288790 + pubmed:29758300 - act(p(FPLX:NFkappaB)) positiveCorrelation path(MESH:"Alzheimer Disease") + deg(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) increases bp(GO:cognition) - pmid:29179999 + pubmed:23516100 - act(p(FPLX:NFkappaB)) association path(HP:Neurodegeneration) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) association act(p(HGNC:CTSD)) - pmid:29179999 + pubmed:31413141 - act(p(FPLX:NFkappaB)) regulates p(FPLX:"NADPH_oxidase") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation p(HGNC:TREM2, frag("?")) - pmid:29179999 + pubmed:24653673 - act(p(FPLX:NFkappaB)) regulates p(HGNC:PTGS2) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) association p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation", Tyr, 307)) - pmid:27288790 + pubmed:24653673 - p(FPLX:NFkappaB) regulates p(HGNC:PTGS2) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) decreases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:MAPT)) - pmid:29179999 + pubmed:24653673 - act(p(FPLX:NFkappaB)) regulates a(MESH:Interleukins) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation a(CHEBI:homocysteine) - pmid:29179999 + pubmed:24653673 - act(p(FPLX:NFkappaB)) regulates p(FPLX:SOD) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) - pmid:29179999 + pubmed:30606258 - act(p(FPLX:NFkappaB)) increases p(HGNC:BACE1) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) - - - pmid:27288790 + pubmed:29758300 - p(FPLX:NFkappaB) association path(MESH:Inflammation) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) decreases act(complex(GO:"proteasome complex")) - pmid:27288790 + pubmed:29758300 - p(FPLX:NFkappaB) association bp(GO:"negative regulation of neuron apoptotic process") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) association complex(GO:"proteasome complex") - pmid:27288790 + pubmed:29758300 - p(FPLX:NFkappaB) association bp(GO:"neuron differentiation") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) association bp(GO:autophagy) - pmid:27288790 + pubmed:29758300 - p(FPLX:NFkappaB) association bp(GO:"apoptotic process") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation p(HGNC:MTOR) - pmid:27288790 + pubmed:29758300 - p(FPLX:NFkappaB) association bp(MESH:"Neuronal Outgrowth") + deg(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) decreases bp(GO:"neuron death") - pmid:27288790 + pubmed:29758300 - p(FPLX:NFkappaB) association bp(GO:"regulation of synaptic plasticity") + deg(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) decreases path(CONSO:neuroinflammation) - pmid:27288790 + pubmed:29758300 - act(p(FPLX:NFkappaB)) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation p(HGNC:TREM2) - pmid:27288790 + pubmed:29758300 - act(p(FPLX:NFkappaB)) increases complex(a(MESH:DNA), p(FPLX:NFkappaB)) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation p(HGNC:MAPT, var("p.Ala152Thr")) - - - pmid:27288790 + pubmed:24027553 - act(p(FPLX:NFkappaB)) increases p(HGNC:IL1B) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) association path(MESH:"Neurofibrillary Tangles") - pmid:27288790 + pubmed:24027553 - act(p(FPLX:NFkappaB)) increases p(HGNC:TNF) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) decreases act(a(CHEBI:Thrombin)) - pmid:27288790 + pubmed:17403556 - act(p(FPLX:NFkappaB)) decreases p(HGNC:UCHL1) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation path(CONSO:Neurodegeneration) - pmid:27288790 + pubmed:22611162 - p(FPLX:NFkappaB) regulates act(p(HGNC:NOS2)) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation p(HGNC:MAPT, var("p.Lys280del")) - pmid:27288790 + pubmed:21882945 - act(p(FPLX:NFkappaB)) increases a(MESH:Cytokines) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) regulates complex(a(GO:microtubule), p(HGNC:MAPT)) - pmid:27288790 + pubmed:21882945 - act(p(FPLX:NFkappaB)) increases a(MESH:Chemokines) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) - pmid:27288790 + pubmed:30985105 - p(FPLX:NFkappaB) increases m(MIRBASE:"hsa-mir-125b-1") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) - pmid:27288790 + pubmed:26631930 - p(FPLX:NFkappaB) increases m(MIRBASE:"hsa-mir-125b-2") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + + - pmid:27288790 + pubmed:14963027 - p(FPLX:NFkappaB) increases m(MIRBASE:"hsa-mir-146a") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) increases complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) - pmid:27288790 + pubmed:21882945 - p(FPLX:NFkappaB) increases m(MIRBASE:"hsa-mir-155") + deg(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) association p(HGNC:BAG2) - pmid:27288790 + pubmed:22419736 - act(p(FPLX:NFkappaB), ma(tscript)) increases m(MIRBASE:"hsa-mir-155") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation act(p(FPLX:AMPK)) - pmid:30640040 + pubmed:22419736 - p(FPLX:NFkappaB) association a(PUBCHEM:5318517) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation p(FPLX:AMPK) - pmid:26118667 + pubmed:22419736 - p(FPLX:NFkappaB) increases complex(g(MIRBASE:"rno-mir-195"), p(FPLX:NFkappaB)) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) association path(MESH:"Retinal Degeneration") - - - - - - - pmid:21329555 + pubmed:29191965 - complex(g(HGNC:BACE1), p(HGNC:RELA)) increases r(HGNC:BACE1) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation a(CONSO:"Tau aggregates") - pmid:21329555 + pubmed:26631930 - p(HGNC:NFKBIA) decreases a(CHEBI:"amyloid-beta") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) increases a(CONSO:"Tau aggregates") - - - - - pmid:29179999 + pubmed:26631930 - p(HGNC:NFKBIA) decreases act(p(FPLX:NFkappaB)) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) increases a(CONSO:"Tau aggregates") - pmid:27288790 + pubmed:22817713 - p(HGNC:NFKBIA) decreases act(p(FPLX:NFkappaB)) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) increases a(CONSO:"Tau aggregates") - - - pmid:21329555 + pubmed:28420982 - bp(GO:"NIK/NF-kappaB signaling") association path(MESH:Inflammation) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) increases a(CONSO:"Tau oligomers") - pmid:21329555 + pubmed:28420982 - bp(GO:"NIK/NF-kappaB signaling") association path(MESH:"Oxidative Stress") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) increases a(CONSO:"Tau oligomers") - pmid:21329555 + pubmed:26631930 - path(MESH:"Oxidative Stress") association bp(GO:"NIK/NF-kappaB signaling") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) decreases complex(a(MESH:Actins), p(HGNC:MAPT)) + + - pmid:30012004 + pubmed:27260836 - path(MESH:"Oxidative Stress") positiveCorrelation path(MESH:"Huntington Disease") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) association p(HGNC:PICALM) - pmid:21329555 + pubmed:18467332 - p(HGNC:TNF) increases bp(GO:"NIK/NF-kappaB signaling") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) decreases complex(p(HGNC:MAPT), p(HGNC:SRC)) - pmid:21329555 + pubmed:18467332 - p(HGNC:TNF) increases r(HGNC:BACE1) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) decreases complex(p(HGNC:MAPT), p(HGNC:PLCG1)) - pmid:21329555 + pubmed:18467332 - p(HGNC:TNF) increases r(HGNC:BACE1) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) decreases complex(p(HGNC:GRB2), p(HGNC:MAPT)) - pmid:25331948 + pubmed:18467332 - p(HGNC:TNF) increases r(HGNC:BACE1) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) decreases complex(p(HGNC:MAPT), p(HGNC:PIK3R1)) - pmid:21329555 + pubmed:10464280 - p(HGNC:TNF) increases act(p(FPLX:NFkappaB), ma(tscript)) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation rxn(reactants(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT))) - pmid:29179999 + pubmed:19363271 - p(HGNC:TNF) increases act(p(FPLX:NFkappaB)) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation p(FPLX:HSP90) + + - pmid:27288790 + pubmed:14612456 - p(HGNC:TNF) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) isA complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")), p(HGNC:STUB1), p(HGNC:UBE2D2)) + + - pmid:27288790 + pubmed:23943618 - p(HGNC:TNF) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation complex(p(FPLX:PPP2), p(HGNC:MAPT)) - pmid:27288790 + pubmed:16630055 - p(HGNC:TNF) increases act(p(FPLX:NFkappaB)) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation p(HGNC:MAPT, pmod(CONSO:O-GlcNAcylation)) + + - pmid:28745240 + pubmed:19401603 - p(HGNC:TNF) increases act(complex(GO:"NF-kappaB complex")) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation complex(a(MESH:Microtubules), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) - pmid:21958873 + pubmed:20869593 - p(HGNC:TNF) increases act(complex(GO:"NF-kappaB complex")) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) - - - pmid:25331948 - - p(HGNC:TNF) increases act(complex(GO:"NF-kappaB complex")) - + - pmid:28745240 + pubmed:24760868 - p(HGNC:TNF) positiveCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNC:MAPT)) association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - - - pmid:27288790 - - p(HGNC:TNF) positiveCorrelation path(MESH:"Alzheimer Disease") - + - pmid:25652642 + pubmed:26195256 - p(HGNC:TNF) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAPT, loc(MESH:"Neurofibrillary Tangles")) positiveCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation), loc(MESH:"Cerebrospinal Fluid")) + + - pmid:28745240 + pubmed:29661268 - p(HGNC:TNF) increases path(HBP:neurotoxicity) + act(p(HGNC:MAPT), ma(GO:"acetyltransferase activity")) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) - - - pmid:28745240 - - p(HGNC:TNF) increases bp(GO:"neuron death") - + - - - pmid:27288790 - - p(HGNC:TNF) increases p(FPLX:"IKK_complex", pmod(Ph)) - + - - - pmid:27288790 - - p(HGNC:TNF) increases p(HGNC:RELA, pmod(Ph)) - + - - - pmid:23178521 - - p(HGNC:TNF) increases p(HGNC:RELA, pmod(Ph)) - + - - - pmid:23178521 - - p(HGNC:TNF) increases p(HGNC:RELA, pmod(Ph)) - + - - - pmid:23178521 - - p(HGNC:TNF) increases p(HGNC:RELA, pmod(Ph)) - + - - - pmid:27288790 - - p(HGNC:TNF) decreases p(FPLX:IKB) - + - pmid:27288790 + pubmed:28760828 - p(HGNC:TNF) increases a(MESH:Cytokines) + p(HGNC:MAPT) causesNoChange p(CONSO:"Tau fibrils") - - - pmid:27288790 - - p(HGNC:TNF) increases a(MESH:Chemokines) - + - - - pmid:27288790 - - p(HGNC:TNF) increases act(p(HGNC:BACE1)) - + + + - pmid:21958873 + pubmed:28760828 - p(HGNC:TNF) increases p(HGNC:BACE1) + p(HGNC:MAPT) increases bp(GO:"microtubule polymerization") - pmid:25331948 + pubmed:29238289 - p(HGNC:TNF) increases p(HGNC:BACE1) + p(HGNC:MAPT) association bp(GO:"microtubule polymerization") - pmid:27288790 + pubmed:2123288 - p(HGNC:TNF) increases act(p(FPLX:ERK)) + act(p(HGNC:MAPT)) increases bp(GO:"microtubule polymerization") - pmid:27288790 + pubmed:16566606 - p(HGNC:TNF) increases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:MAPT) increases bp(GO:"microtubule polymerization") - - - pmid:25652642 - - p(HGNC:TNF) increases p(HGNC:NGF) - + - - - pmid:25652642 - - p(HGNC:TNF) increases p(HGNC:BCL2) - + - - - pmid:19126755 - - p(HGNC:TNF) increases bp(GO:"MAPK cascade") - + - - - pmid:19293145 - - p(HGNC:TNF) increases act(a(CHEBI:nicotine)) - + - - - pmid:19293145 - - p(HGNC:TNF) decreases act(a(CHEBI:"N-methyl-D-aspartic acid")) - + - pmid:23178521 + pubmed:26631930 - p(HGNC:TNF) causesNoChange p(HGNC:STAT3, pmod(Ph)) + p(HGNC:MAPT) directlyIncreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) - - - pmid:23178521 - - p(HGNC:TNF) increases p(HGNC:STAT3, pmod(Ph)) - + - - - pmid:23178521 - - p(HGNC:TNF) increases p(HGNC:STAT3, pmod(Ph)) - + - - - pmid:25331948 - - p(HGNC:TNF) increases a(MESH:"Amyloid beta-Peptides") - + + + - pmid:21329555 + pubmed:21339331 - a(CHEBI:"acetylsalicylic acid") decreases r(HGNC:BACE1) + p(HGNC:MAPT) causesNoChange p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) + + - pmid:21329555 + pubmed:21339331 - a(CHEBI:"acetylsalicylic acid") decreases r(HGNC:BACE1) + p(HGNC:MAPT) causesNoChange p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) - - - pmid:21329555 - - a(CHEBI:"acetylsalicylic acid") isA a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") - + - - - pmid:21329555 - - a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") decreases r(HGNC:BACE1) - + + + - pmid:27288790 + pubmed:2446784 - a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") decreases act(p(HGNC:BACE1)) + p(HGNC:MAPT) association complex(a(MESH:Microtubules), p(HGNC:MAPT)) - - - pmid:19126755 - - a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") decreases act(p(HGNC:PTGS1)) - + - - - pmid:19126755 - - a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") decreases act(p(HGNC:PTGS2)) - + - - - pmid:21329555 - - a(CHEBI:ibuprofen) isA a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") - + - - - pmid:27288790 - - a(CHEBI:ibuprofen) isA a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") - + - - - pmid:21329555 - - a(CHEBI:ibuprofen) decreases r(HGNC:BACE1) - + - pmid:27288790 + pubmed:29661268 - a(CHEBI:ibuprofen) decreases r(HGNC:BACE1) + p(HGNC:MAPT) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys)) + + - pmid:27288790 + pubmed:29661268 - a(CHEBI:ibuprofen) decreases a(CHEBI:"amyloid-beta") + p(HGNC:MAPT) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Cys, 291)) + + - pmid:21329555 + pubmed:29661268 - a(PUBCHEM:3715) isA a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") + p(HGNC:MAPT) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Cys, 322)) - - - pmid:21329555 - - a(PUBCHEM:3715) decreases r(HGNC:BACE1) - + - pmid:28745240 + pubmed:29661268 - p(HGNC:SYP) increases complex(p(HGNC:NFKB1), p(HGNC:RELA), p(HGNC:SYP)) + p(HGNC:MAPT) negativeCorrelation act(p(HGNC:SIRT1)) - - - pmid:26813123 - - p(HGNC:SYP) association bp(GO:memory) - + + + + + + + + + + + + + + + + + + + @@ -26202,1221 +26192,1224 @@

Statements

- pmid:28745240 + pubmed:29661268 - p(HGNC:NFKB1) increases bp(GO:"long-term synaptic potentiation") + p(HGNC:MAPT) increases act(p(HGNC:STUB1)) + + + + - pmid:28745240 + pubmed:25116835 - p(HGNC:NFKB1) increases path(MESH:"Spatial Memory") + p(HGNC:MAPT) negativeCorrelation p(HGNC:DYRK1A) - pmid:28745240 + pubmed:22110360 - p(HGNC:NFKB1) increases bp(GO:learning) + p(HGNC:MAPT) association p(HGNC:DYRK1A) + + - pmid:28745240 + pubmed:21339331 - p(HGNC:NFKB1) increases path(MESH:Anxiety) + p(HGNC:MAPT) causesNoChange p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 212)) - pmid:27288790 + pubmed:27041503 - act(p(HGNC:NFKB1)) increases bp(GO:"apoptotic process") + p(HGNC:MAPT) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:23702978 + pubmed:25514383 - p(HGNC:NFKB1) increases p(HGNC:IL1B) + p(HGNC:MAPT) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:28745240 + pubmed:29758300 - a(GO:synapse) association complex(p(HGNC:NFKB1), p(HGNC:RELA)) + p(HGNC:MAPT) association path(MESH:"Alzheimer Disease") - pmid:30061532 + pubmed:14556719 - act(a(GO:synapse)) association path(HBP:Neurodegeneration) + p(HGNC:MAPT) association path(MESH:"Alzheimer Disease") - pmid:30061532 + pubmed:24027553 - a(GO:synapse) association p(HGNC:DISC1) + p(HGNC:MAPT) association path(MESH:"Alzheimer Disease") - pmid:26813123 + pubmed:24027553 - a(GO:synapse) negativeCorrelation path(MESH:"Cognitive Dysfunction") + p(HGNC:MAPT) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:25514383 + pubmed:27574109 - a(GO:synapse) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAPT) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:22908190 + pubmed:27574109 - act(a(GO:synapse)) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAPT) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:22908190 + pubmed:30126037 - act(a(GO:synapse)) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAPT) association path(MESH:"Alzheimer Disease") - pmid:28445721 + pubmed:28420982 - act(a(GO:synapse)) regulates p(FPLX:CHRN) + p(HGNC:MAPT) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:30106381 + pubmed:28420982 - act(a(GO:synapse)) association p(HGNC:ADNP) + p(HGNC:MAPT) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:30106381 + pubmed:26631930 - act(a(GO:synapse)) association a(PUBCHEM:9832404) + p(HGNC:MAPT) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:22908190 + pubmed:29238289 - act(a(GO:synapse)) positiveCorrelation bp(GO:cognition) + p(HGNC:MAPT) biomarkerFor path(MESH:"Alzheimer Disease") - pmid:22908190 + pubmed:25024322 - act(a(GO:synapse)) decreases path(MESH:"Plaque, Amyloid") + p(HGNC:MAPT) positiveCorrelation p(HGNC:CHI3L1) - pmid:22908190 + pubmed:25865441 - act(a(GO:synapse)) positiveCorrelation bp(GO:endocytosis) + p(HGNC:MAPT) positiveCorrelation p(HGNC:CHI3L1) - pmid:22908190 + pubmed:25865441 - act(a(GO:synapse)) positiveCorrelation p(HGNC:CTSB) + p(HGNC:MAPT) positiveCorrelation p(HGNC:CHI3L1) - pmid:26631930 + pubmed:26836182 - act(a(GO:synapse)) increases tloc(p(HGNC:MAPT), fromLoc(GO:"dendritic shaft"), toLoc(GO:"excitatory synapse")) + p(HGNC:MAPT) positiveCorrelation p(HGNC:CHI3L1) - pmid:26631930 + pubmed:26836182 - act(a(GO:synapse)) negativeCorrelation p(HGNC:MAPT) + p(HGNC:MAPT) positiveCorrelation p(HGNC:CHI3L1) - pmid:27796283 + pubmed:26235064 - act(a(GO:synapse)) negativeCorrelation act(p(HGNC:RHOA)) + p(HGNC:MAPT) association bp(GO:"neuron death") - pmid:27796283 + pubmed:28420982 - a(GO:synapse) regulates p(HGNC:CAMKV) + p(HGNC:MAPT) increases bp(GO:"neuron death") - pmid:22156579 + pubmed:29238289 - a(GO:synapse) negativeCorrelation p(HGNC:MARK4) + p(HGNC:MAPT) causesNoChange bp(GO:"neuron death") - - - - - pmid:28745240 + pubmed:26235064 - complex(p(HGNC:NFKB1), p(HGNC:RELA)) association a(GO:synapse) + p(HGNC:MAPT) association bp(GO:cognition) - pmid:28745240 + pubmed:3122646 - complex(p(HGNC:NFKB1), p(HGNC:RELA)) increases complex(p(HGNC:BACE1), p(HGNC:NFKB1), p(HGNC:RELA)) + p(HGNC:MAPT) association a(NIFT:"White matter") - pmid:25652642 + pubmed:19293145 - act(complex(p(HGNC:NFKB1), p(HGNC:RELA))) increases bp(GO:"apoptotic process") + p(HGNC:MAPT) association a(MESH:"Neurofibrillary Tangles") - pmid:21214928 + pubmed:14556719 - bp(MESH:"Synaptic Transmission") association a(CHEBI:"amyloid-beta") + p(HGNC:MAPT) association a(MESH:"Neurofibrillary Tangles") - pmid:26813123 + pubmed:14556719 - bp(MESH:"Synaptic Transmission") association bp(GO:memory) + deg(p(HGNC:MAPT)) increases a(MESH:"Neurofibrillary Tangles") - pmid:14556719 + pubmed:27574109 - bp(MESH:"Synaptic Transmission") association p(HGNC:PRKN) + p(HGNC:MAPT) association a(MESH:"Neurofibrillary Tangles") + + - pmid:28745240 + pubmed:18680553 - bp(GO:"long-term synaptic potentiation") decreases p(HGNC:NFKB1) + p(HGNC:MAPT) increases complex(p(HGNC:FYN), p(HGNC:MAPT)) - pmid:28745240 + pubmed:18680553 - bp(GO:"long-term synaptic potentiation") decreases p(HGNC:RELA) + p(HGNC:MAPT) increases complex(p(HGNC:FYN), p(HGNC:MAPT)) - - - pmid:19126755 - - bp(GO:"long-term synaptic potentiation") increases bp(GO:"depolarization of postsynaptic membrane") - + + + - pmid:19126755 + pubmed:26813123 - bp(GO:"long-term synaptic potentiation") increases bp(GO:"receptor clustering") + act(p(HGNC:MAPT)) association act(p(HGNC:CHRM1)) + + - pmid:24511233 + pubmed:24590577 - bp(GO:"long-term synaptic potentiation") association bp(GO:learning) + p(HGNC:MAPT) regulates bp(GO:"microtubule anchoring") - pmid:24511233 + pubmed:24590577 - bp(GO:"long-term synaptic potentiation") association bp(GO:memory) + p(HGNC:MAPT) regulates bp(GO:"axonal transport") - pmid:21787755 + pubmed:12428809 - bp(GO:"long-term synaptic potentiation") association a(HBP:"alpha-7-containing nAChR") + p(HGNC:MAPT) association bp(GO:"axonal transport") - pmid:22908190 + pubmed:12428809 - bp(GO:"long-term synaptic potentiation") negativeCorrelation act(p(HGNC:RAB5A)) + p(HGNC:MAPT) increases bp(GO:"axonal transport") - pmid:24760868 + pubmed:21734277 - bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:MAPT) + tloc(p(HGNC:MAPT)) causesNoChange bp(GO:"axonal transport") - pmid:24760868 + pubmed:28420982 - bp(GO:"long-term synaptic potentiation") positiveCorrelation tloc(p(HGNC:MAPT), fromLoc(GO:"dendritic shaft"), toLoc(GO:synapse)) + p(HGNC:MAPT) regulates bp(GO:"axonal transport") - pmid:24760868 + pubmed:26631930 - bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:MAPT) + p(HGNC:MAPT) regulates bp(GO:"axonal transport") + + - pmid:24760868 + pubmed:26837465 - bp(GO:"long-term synaptic potentiation") positiveCorrelation p(MESH:Actins) + p(HGNC:MAPT) decreases act(p(HGNC:ESR1), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) + + - pmid:24760868 + pubmed:22908190 - bp(GO:"long-term synaptic potentiation") positiveCorrelation p(MESH:Actins) + deg(p(HGNC:MAPT)) increases p(HGNC:MAPT, frag("?")) - - - pmid:24760868 - - bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:FYN) - + - - - pmid:24760868 - - bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:GRIA1) - + - - - pmid:24760868 - - bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:GRIA1) - + - - - pmid:24760868 - - bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:DLG4) - + - - - pmid:24760868 - - bp(GO:"long-term synaptic potentiation") decreases complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) - + - - - pmid:24760868 - - bp(GO:"long-term synaptic potentiation") increases p(HGNC:MAPT, pmod(Ph, Thr, 205)) - + + + - pmid:24760868 + pubmed:23516100 - bp(GO:"long-term synaptic potentiation") increases p(HGNC:MAPT, var("p.T205A"), loc(MESH:"Dendritic Spines")) + p(HGNC:MAPT) increases p(CONSO:"Tau aggregates") - pmid:21882945 + pubmed:29238289 - bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:HSPB1) + p(HGNC:MAPT) decreases tloc(p(CONSO:"Tau aggregates"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) - - - pmid:28745240 - - p(HGNC:REL) increases bp(GO:"long-term synaptic depression") - + - - - pmid:28745240 - - bp(GO:"long-term synaptic depression") decreases p(HGNC:NFKB1) - + - pmid:28745240 + pubmed:10391244 - bp(GO:"long-term synaptic depression") decreases p(HGNC:RELA) + act(p(HGNC:MAPT), ma(GO:"microtubule binding")) negativeCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) - - - pmid:22908190 - - bp(GO:"long-term synaptic depression") negativeCorrelation act(p(HGNC:RAB5A)) - + - pmid:28745240 + pubmed:21339331 - a(CHEBI:"glutamate(1-)") increases act(a(GO:"excitatory synapse")) + p(HGNC:MAPT) causesNoChange p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) - - - pmid:25652642 - - a(CHEBI:"glutamate(1-)") increases act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) - + - - - pmid:25652642 - - a(CHEBI:"glutamate(1-)") increases act(complex(p(HGNC:NFKB1), p(HGNC:RELA))) - + + + - pmid:16273023 + pubmed:31413141 - a(CHEBI:"glutamate(1-)") association path(MESH:D013850) + p(HGNC:MAPT) positiveCorrelation p(HGNC:TREM2, frag("?")) + + - pmid:16273023 + pubmed:19277525 - a(CHEBI:"glutamate(1-)") association path(MESH:D008568) + p(HGNC:MAPT) increases complex(p(HGNC:MAPT), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) - - - pmid:27087442 - - a(CHEBI:"glutamate(1-)") increases p(HBP:"CDK5R1 p25") - + + + - pmid:28745240 + pubmed:21882945 - act(a(GO:"excitatory synapse")) increases act(complex(GO:"NF-kappaB complex")) + p(HGNC:MAPT) increases complex(a(GO:microtubule), p(HGNC:MAPT)) - pmid:28745240 + pubmed:29191965 - act(a(GO:"excitatory synapse")) increases act(complex(GO:"NF-kappaB complex")) + p(HGNC:MAPT) increases complex(a(GO:microtubule), p(HGNC:MAPT)) - pmid:28745240 + pubmed:26631930 - act(a(GO:"excitatory synapse")) increases act(complex(GO:"NF-kappaB complex")) + p(HGNC:MAPT) directlyIncreases complex(a(GO:microtubule), p(HGNC:MAPT)) + + - pmid:28745240 + pubmed:12428809 - path(HBP:Excitotoxicity) increases bp(GO:"neuron death") + p(HGNC:MAPT) increases bp(GO:"microtubule cytoskeleton organization") - pmid:30012004 + pubmed:12428809 - path(HBP:Excitotoxicity) positiveCorrelation path(MESH:"Huntington Disease") + p(HGNC:MAPT) decreases bp(GO:"microtubule depolymerization") - pmid:21722302 + pubmed:12428809 - path(HBP:Excitotoxicity) increases bp(GO:"motor neuron apoptotic process") + p(HGNC:MAPT) increases bp(GO:"axon development") - - - pmid:24027553 - - path(HBP:Excitotoxicity) increases a(CHEBI:"calcium(2+)", loc(GO:intracellular)) - + - - - pmid:24027553 - - path(HBP:Excitotoxicity) association act(p(HGNCGENEFAMILY:Calpains)) - + - - - pmid:27607061 - - path(HBP:Excitotoxicity) negativeCorrelation surf(p(HGNC:GRIK2)) - + - - - pmid:28745240 - - a(MESH:"Receptors, N-Methyl-D-Aspartate") regulates bp(GO:"calcium ion import") - + - - - pmid:28745240 - - a(MESH:"Receptors, N-Methyl-D-Aspartate") regulates act(p(HGNC:CAMK2A)) - + - pmid:21214928 + pubmed:28148553 - a(MESH:"Receptors, N-Methyl-D-Aspartate") increases p(HBP:HBP00064) + p(HGNC:MAPT) association bp(MESH:"Unfolded Protein Response") - - - pmid:21214928 - - a(MESH:"Receptors, N-Methyl-D-Aspartate") increases p(HBP:HBP00065) - + + + - pmid:21214928 + pubmed:30108137 - a(MESH:"Receptors, N-Methyl-D-Aspartate") increases a(CHEBI:"amyloid-beta") + tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association path(CONSO:"Pathological Tau Spreading") - pmid:22122372 + pubmed:29758300 - a(MESH:"Receptors, N-Methyl-D-Aspartate") increases a(HBP:HBP00064) + p(HGNC:MAPT) increases complex(a(GO:cytoskeleton), a(GO:microtubule)) - pmid:22122372 + pubmed:29758300 - a(MESH:"Receptors, N-Methyl-D-Aspartate") increases a(HBP:HBP00065) + p(HGNC:MAPT) increases bp(GO:"anterograde axonal protein transport") - pmid:22122372 + pubmed:27373205 - a(MESH:"Receptors, N-Methyl-D-Aspartate") decreases a(HBP:HBP00063) + p(HGNC:MAPT) causesNoChange bp(GO:"anterograde axonal protein transport") - pmid:25514383 + pubmed:29758300 - a(MESH:"Receptors, N-Methyl-D-Aspartate") regulates tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + p(HGNC:MAPT) increases bp(GO:"retrograde axonal protein transport") - pmid:24653673 + pubmed:27373205 - a(MESH:"Receptors, N-Methyl-D-Aspartate") association path(MESH:"Alzheimer Disease") + p(HGNC:MAPT) causesNoChange bp(GO:"retrograde axonal protein transport") - pmid:26751493 + pubmed:29758300 - a(MESH:"Receptors, N-Methyl-D-Aspartate") association p(HBP:"projection domain") + p(HGNC:MAPT) association path(MESH:Tauopathies) - pmid:27796283 + pubmed:29758300 - a(MESH:"Receptors, N-Methyl-D-Aspartate") increases act(p(HGNC:RAC1)) + p(HGNC:MAPT) association path(MESH:"Frontotemporal Dementia") - pmid:27796283 + pubmed:28420982 - a(MESH:"Receptors, N-Methyl-D-Aspartate") increases p(HGNC:TIAM1, pmod(Ph)) + p(HGNC:MAPT) positiveCorrelation path(MESH:"Frontotemporal Dementia") - pmid:22833681 + pubmed:29758300 - act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) increases p(HBP:"Tau epitope, AT8") + p(HGNC:MAPT) association path(MESH:"Niemann-Pick Diseases") - pmid:22833681 + pubmed:29758300 - act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) increases p(HBP:"Tau epitope, PHF1") + p(HGNC:MAPT) association path(MESH:"Supranuclear Palsy, Progressive") - pmid:22833681 + pubmed:30126037 - act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) increases p(HBP:"Tau epitope, AT180") + p(HGNC:MAPT) association path(MESH:"Supranuclear Palsy, Progressive") - pmid:22833681 + pubmed:29758300 - act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) decreases p(HBP:"Tau epitope, AT100") + p(HGNC:MAPT) association p(HGNC:NBR1) - - - pmid:22833681 - - act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) positiveCorrelation path(HBP:"Long-Term Depression") - + - pmid:22833681 + pubmed:29758300 - act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) increases complex(p(HGNC:FYN), p(HGNC:MAPT)) + p(HGNC:MAPT) positiveCorrelation p(HGNC:TREM2) - - - pmid:28745240 - - bp(GO:"calcium ion import") increases act(complex(GO:"NF-kappaB complex")) - + - pmid:28745240 + pubmed:14556719 - bp(GO:"calcium ion import") increases act(p(HGNC:CAMK2A)) + p(HGNC:MAPT) association a(GO:microtubule) - pmid:28745240 + pubmed:25374103 - bp(GO:"calcium ion import") increases act(p(FPLX:PKC)) + p(HGNC:MAPT) regulates act(a(GO:microtubule)) - pmid:28745240 + pubmed:28420982 - bp(GO:"calcium ion import") increases act(complex(GO:"phosphatidylinositol 3-kinase complex")) + p(HGNC:MAPT) increases a(GO:microtubule) - pmid:28745240 + pubmed:26631930 - bp(GO:"calcium ion import") increases act(p(FPLX:AKT)) + tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) negativeCorrelation a(GO:microtubule) - pmid:26813123 + pubmed:29626319 - bp(GO:"calcium ion import") regulates act(p(HGNC:CHAT)) + p(HGNC:MAPT) increases a(GO:microtubule) - pmid:28745240 + pubmed:22908190 - act(p(HGNC:CAMK2A)) increases act(complex(GO:"NF-kappaB complex")) + p(HGNC:MAPT) association a(CONSO:"paired helical filaments") - pmid:28745240 + pubmed:22908190 - act(p(HGNC:CAMK2A)) increases act(complex(GO:"NF-kappaB complex")) + p(HGNC:MAPT) association a(CONSO:"paired helical filaments") - pmid:28745240 + pubmed:22908190 - act(p(HGNC:CAMK2A)) increases act(complex(GO:"IkappaB kinase complex")) + p(HGNC:MAPT) association a(GO:"Lewy body") - pmid:28745240 + pubmed:22908190 - act(p(HGNC:CAMK2A)) increases p(MESH:"I-kappa B Kinase", pmod(Ph)) + p(HGNC:MAPT) association a(GO:"Pick body") - pmid:22122372 + pubmed:27574109 - p(HGNC:CAMK2A) increases p(HBP:HBP00071, pmod(Ph, Thr, 654)) + p(HGNC:MAPT) association a(GO:"Pick body") - pmid:22122372 + pubmed:22908190 - p(HGNC:CAMK2A) increases p(HBP:HBP00071, pmod(Ph, Thr, 668)) + p(HGNC:MAPT) causesNoChange act(complex(GO:"proteasome complex")) - pmid:22122372 + pubmed:22908190 - p(HGNC:CAMK2A) increases p(HBP:HBP00071, pmod(Ph, Ser, 665)) + p(HGNC:MAPT) negativeCorrelation act(complex(GO:"proteasome complex")) - pmid:26631930 + pubmed:26751493 - p(HGNC:CAMK2A) directlyIncreases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:MAPT) negativeCorrelation act(complex(GO:"proteasome complex")) - pmid:26631930 + pubmed:30145931 - p(HGNC:CAMK2A) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + p(HGNC:MAPT) increases p(HGNC:SQSTM1) + + - pmid:28745240 + pubmed:30145931 - act(p(FPLX:PKC)) increases act(complex(GO:"NF-kappaB complex")) + p(HGNC:MAPT, loc(MESH:Dendrites)) decreases a(MESH:"Dendritic Spines") + + + + - pmid:28745240 + pubmed:30116051 - act(p(FPLX:PKC)) increases act(complex(GO:"NF-kappaB complex")) + p(HGNC:MAPT) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:28745240 + pubmed:23528736 - act(p(FPLX:PKC)) increases act(complex(GO:"NF-kappaB complex")) + deg(p(HGNC:MAPT)) association bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:25652642 + pubmed:29215007 - act(p(FPLX:PKC)) increases act(complex(GO:"NF-kappaB complex")) + p(HGNC:MAPT) increases bp(GO:"actin filament bundle assembly") - pmid:28745240 + pubmed:29215007 - act(p(FPLX:PKC)) increases act(complex(GO:"IkappaB kinase complex")) + p(HGNC:MAPT) increases bp(GO:"actin filament bundle assembly") + + - pmid:28745240 + pubmed:24760868 - act(p(FPLX:PKC)) increases p(MESH:"I-kappa B Kinase", pmod(Ph)) + p(HGNC:MAPT, loc(GO:synapse)) increases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - pmid:18650430 + pubmed:24027553 - p(FPLX:PKC) increases sec(p(HGNC:APP)) + p(HGNC:MAPT) negativeCorrelation act(a(MESH:Neurons)) - pmid:24590577 + pubmed:26631930 - act(p(FPLX:PKC)) increases tloc(p(HGNC:APP), fromLoc(GO:"Golgi apparatus"), toLoc(GO:"cell surface")) + p(HGNC:MAPT) regulates act(a(MESH:Neurons)) - pmid:26813123 + pubmed:26631930 - p(FPLX:PKC) increases p(HGNC:SLC18A3, pmod(Ph)) + p(HGNC:MAPT) increases a(MESH:Neurons) - pmid:26813123 + pubmed:26631930 - p(FPLX:PKC) increases p(FPLX:CHRN, pmod(Ph)) + p(HGNC:MAPT) increases act(a(MESH:Neurons)) - pmid:24590577 + pubmed:29238289 - act(p(FPLX:PKC)) increases act(p(HGNC:ADAM10)) + p(HGNC:MAPT, loc(GO:"extracellular region")) increases act(a(MESH:Neurons)) - pmid:24590577 + pubmed:29238289 - act(p(FPLX:PKC)) increases p(HGNC:BACE1) + tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) increases act(a(MESH:Neurons)) + + + + + + + + + + + + + + + + + + + + + + - pmid:24590577 + pubmed:27574109 - act(p(FPLX:PKC)) decreases act(p(HGNC:GSK3B)) + p(HGNC:MAPT) association a(CONSO:pretangles) - pmid:17493042 + pubmed:27574109 - p(FPLX:PKC) increases p(HGNC:MAPT, pmod(Ph, Ser, 214)) + p(HGNC:MAPT) association a(CONSO:"Braak_Stage I") - pmid:28745240 + pubmed:27574109 - act(complex(GO:"phosphatidylinositol 3-kinase complex")) increases act(complex(GO:"NF-kappaB complex")) + p(HGNC:MAPT) association a(CONSO:"Braak_Stage II") - pmid:28745240 + pubmed:27574109 - act(complex(GO:"phosphatidylinositol 3-kinase complex")) increases act(complex(GO:"IkappaB kinase complex")) + p(HGNC:MAPT) association path(CONSO:"Corticobasal Degeneration") - pmid:28745240 + pubmed:27574109 - act(complex(GO:"phosphatidylinositol 3-kinase complex")) increases p(MESH:"I-kappa B Kinase", pmod(Ph)) + p(HGNC:MAPT) positiveCorrelation path(CONSO:"Corticobasal Degeneration") - pmid:28745240 + pubmed:27574109 - act(p(FPLX:AKT)) increases act(complex(GO:"NF-kappaB complex")) + p(HGNC:MAPT) positiveCorrelation path(CONSO:"Corticobasal Degeneration") - pmid:28745240 + pubmed:27574109 - act(p(FPLX:AKT)) increases act(complex(GO:"IkappaB kinase complex")) + p(HGNC:MAPT) positiveCorrelation path(MESH:"Pick Disease of the Brain") - pmid:28745240 + pubmed:27574109 - act(p(FPLX:AKT)) increases p(MESH:"I-kappa B Kinase", pmod(Ph)) + p(HGNC:MAPT) positiveCorrelation path(MESH:"Pick Disease of the Brain") + + + + + + + + + + - pmid:27288790 + pubmed:29590627 - act(p(FPLX:AKT)) increases p(HGNC:RELA) + p(HGNC:MAPT) increases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) - pmid:30061532 + pubmed:26195256 - p(FPLX:AKT) regulates act(p(HGNC:MTOR)) + p(HGNC:MAPT, loc(MESH:"Cerebrospinal Fluid")) positiveCorrelation p(HGNC:MAPT, loc(MESH:"Neurofibrillary Tangles")) - - - pmid:19293145 + pubmed:26195256 - act(p(FPLX:AKT)) decreases bp(GO:"apoptotic process") + p(HGNC:MAPT, loc(MESH:"Neurofibrillary Tangles")) positiveCorrelation p(HGNC:MAPT, loc(MESH:"Cerebrospinal Fluid")) - pmid:23454242 + pubmed:26631930 - p(FPLX:AKT) regulates bp(GO:"apoptotic process") + tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) positiveCorrelation p(HGNC:MAPT) - pmid:19293145 + pubmed:26631930 - p(FPLX:AKT) association bp(GO:"insulin receptor signaling pathway") + p(HGNC:MAPT) positiveCorrelation tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) + + + + + + + + - pmid:25514383 + pubmed:24760868 - act(p(FPLX:AKT)) decreases bp(HP:Neurodegeneration) + p(HGNC:MAPT) positiveCorrelation bp(GO:"long-term synaptic potentiation") - DOI:10.4172/2168-975X.1000126 + pubmed:24760868 - p(FPLX:AKT) directlyIncreases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) + tloc(p(HGNC:MAPT), fromLoc(GO:"dendritic shaft"), toLoc(GO:synapse)) positiveCorrelation bp(GO:"long-term synaptic potentiation") - pmid:25331948 + pubmed:24760868 - p(FPLX:AKT) regulates p(HGNC:GSK3B, pmod(Ph, Ser, 9)) + p(HGNC:MAPT) positiveCorrelation bp(GO:"long-term synaptic potentiation") - pmid:29121589 + pubmed:24760868 - p(FPLX:AKT) increases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) + tloc(p(HGNC:MAPT), fromLoc(GO:"dendritic shaft"), toLoc(GO:synapse)) association bp(MESH:"Neuronal Plasticity") - pmid:29844403 + pubmed:24760868 - p(FPLX:AKT) increases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) + p(HGNC:MAPT) regulates bp(MESH:"Neuronal Plasticity") @@ -27425,18 +27418,18 @@

Statements

- pmid:23454242 + pubmed:24760868 - p(FPLX:AKT) regulates bp(GO:"cell growth") + p(HGNC:MAPT) increases complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) - pmid:23454242 + pubmed:17187063 - p(FPLX:AKT) regulates bp(GO:"cell population proliferation") + p(HGNC:MAPT) increases complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) @@ -27445,37 +27438,34 @@

Statements

- pmid:29121589 + pubmed:24760868 - p(FPLX:AKT) positiveCorrelation p(HGNC:NFE2L2) + p(HGNC:MAPT) increases complex(complex(GO:"actin filament bundle"), p(HGNC:MAPT)) - pmid:29121589 + pubmed:24760868 - p(FPLX:AKT) regulates act(p(MGI:Gsk3b)) + p(HGNC:MAPT) association complex(GO:"filamentous actin") - pmid:28745240 + pubmed:17187063 - act(complex(GO:"IkappaB kinase complex")) increases act(complex(GO:"NF-kappaB complex")) + p(HGNC:MAPT) directlyIncreases complex(GO:"filamentous actin") - - - pmid:28745240 - - p(MESH:"I-kappa B Kinase", pmod(Ph)) increases act(complex(GO:"IkappaB kinase complex")) - + + + @@ -27483,697 +27473,508 @@

Statements

- pmid:24511233 + pubmed:28528849 - bp(GO:behavior) association path(MESH:Schizophrenia) + p(HGNC:MAPT) causesNoChange a(GO:synapse) - pmid:24511233 + pubmed:26631930 - bp(GO:behavior) association bp(GO:"synaptic transmission, cholinergic") + tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) decreases act(a(GO:synapse)) - pmid:28420982 + pubmed:26631930 - bp(GO:behavior) association p(HGNC:MAPT) + tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) decreases act(a(GO:synapse)) - pmid:17009926 + pubmed:26631930 - path(MESH:Anxiety) association p(FPLX:CHRN) + p(HGNC:MAPT) negativeCorrelation act(a(GO:synapse)) + + - pmid:11230871 + pubmed:25887395 - path(MESH:Anxiety) association p(FPLX:CHRN) + p(HGNC:MAPT) causesNoChange tloc(a(CONSO:"Tau fibrils"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) - pmid:21482353 + pubmed:29980653 - path(MESH:Anxiety) association bp(GO:"synaptic transmission, cholinergic") + tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) increases a(CONSO:"Tau fibrils") - pmid:28901280 + pubmed:24869773 - path(MESH:Anxiety) association p(MESH:"Receptors, Nicotinic") + p(HGNC:MAPT) association a(CONSO:"Tau fibrils") - pmid:28775333 + pubmed:25887395 - path(MESH:Anxiety) positiveCorrelation p(MGI:Dyrk1a) + p(HGNC:MAPT) causesNoChange a(CONSO:"Tau aggregates") - pmid:28745240 + pubmed:25374103 - act(p(HGNC:PRKACA)) increases act(p(HGNC:CREB1)) + tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) increases a(CONSO:"Tau aggregates") - pmid:21214928 + pubmed:28420982 - p(HGNC:PRKACA) decreases a(CHEBI:"amyloid-beta") + tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association a(CONSO:"Tau aggregates") - pmid:8282104 + pubmed:27373205 - p(HGNC:PRKACA) association a(GO:microtubule) + p(HGNC:MAPT) increases a(CONSO:"Tau aggregates") - - - pmid:8282104 - - p(HGNC:PRKACA) association a(HBP:HBP00006) - - - pmid:28745240 + pubmed:21882945 - act(p(HGNC:CREB1)) increases bp(GO:"long-term memory") + deg(p(HGNC:MAPT)) negativeCorrelation bp(GO:aging) - - - pmid:28745240 + pubmed:21882945 - bp(GO:"calcium ion homeostasis") increases act(complex(GO:"NF-kappaB complex")) + p(HGNC:MAPT) increases path(CONSO:neurotoxicity) - pmid:21214928 + pubmed:21882945 - bp(GO:"calcium ion homeostasis") association p(HGNC:APP) + deg(p(HGNC:MAPT)) negativeCorrelation p(HGNC:AKT1) - - - pmid:19293145 - - bp(GO:"calcium ion homeostasis") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - + - - - pmid:21722302 - - bp(GO:"calcium ion homeostasis") association p(HGNC:BCL2) - + - pmid:21722302 + pubmed:20071522 - bp(GO:"calcium ion homeostasis") increases p(MESH:"Molecular Chaperones", loc(GO:"endoplasmic reticulum")) + p(HGNC:MAPT) isA complex(p(HGNC:FKBP5), p(HGNC:MAPT)) - - - pmid:21722302 - - bp(GO:"calcium ion homeostasis") increases act(p(MESH:"Molecular Chaperones", loc(GO:"endoplasmic reticulum"))) - - - pmid:21722302 + pubmed:30126037 - bp(GO:"calcium ion homeostasis") increases bp(GO:"protein folding") + p(HGNC:MAPT) association path(MESH:"Brain Injuries, Traumatic") - - - pmid:21722302 - - bp(GO:"calcium ion homeostasis") increases bp(MESH:"Unfolded Protein Response") - + - - - pmid:29758300 - - bp(GO:"calcium ion homeostasis") association p(HGNC:PSEN1) - + - - - pmid:28745240 - - bp(MESH:"Oxidative Stress") association a(CHEBI:"amyloid-beta") - + - pmid:28745240 + pubmed:22419736 - bp(MESH:"Oxidative Stress") increases act(complex(GO:"NF-kappaB complex")) + p(HGNC:MAPT) increases path(MESH:"Retinal Degeneration") - - - pmid:28745240 - - bp(MESH:"Oxidative Stress") increases act(complex(GO:"NF-kappaB complex")) - - - pmid:28745240 + pubmed:29191965 - bp(MESH:"Oxidative Stress") increases act(complex(GO:"NF-kappaB complex")) + p(HGNC:MAPT) increases complex(p(HGNC:MAPT), p(HGNC:TUBA1A)) - - - pmid:28745240 - - bp(MESH:"Oxidative Stress") increases bp(GO:"apoptotic process") - - - pmid:25652642 + pubmed:29191965 - bp(MESH:"Oxidative Stress") increases bp(GO:"apoptotic process") + p(HGNC:MAPT) increases complex(p(HGNC:MAPT), p(HGNC:TUBB)) - - - pmid:27623715 - - bp(MESH:"Oxidative Stress") causesNoChange bp(GO:"apoptotic process") - + - - - pmid:22020111 - - bp(MESH:"Oxidative Stress") positiveCorrelation path(MESH:"Colorectal Neoplasms") - + - pmid:22020111 + pubmed:29191965 - bp(MESH:"Oxidative Stress") positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAPT) association a(GO:"cell body") - - - pmid:26195256 - - bp(MESH:"Oxidative Stress") increases path(MESH:"Alzheimer Disease") - + - pmid:21722302 + pubmed:25374103 - bp(MESH:"Oxidative Stress") increases bp(GO:"motor neuron apoptotic process") + p(HGNC:MAPT) decreases bp(GO:"anterograde axonal transport") - pmid:26195256 + pubmed:26631930 - bp(MESH:"Oxidative Stress") increases path(MESH:Aging) + p(HGNC:MAPT) decreases bp(GO:"anterograde axonal transport") - pmid:26195256 + pubmed:28420982 - bp(MESH:"Oxidative Stress") decreases bp(GO:"establishment of blood-brain barrier") + p(HGNC:MAPT) regulates bp(GO:"generation of neurons") - pmid:21131359 + pubmed:28420982 - bp(MESH:"Oxidative Stress") increases tloc(p(HGNC:MAPT), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) + p(HGNC:MAPT) increases bp(HP:Neurodegeneration) - pmid:27623715 + pubmed:28420982 - bp(MESH:"Oxidative Stress") increases act(p(FPLX:JNK)) + p(HGNC:MAPT) increases bp(GO:"cell death") - pmid:27623715 + pubmed:28420982 - bp(MESH:"Oxidative Stress") increases act(a(MESH:"Microtubule-Associated Proteins")) + p(HGNC:MAPT) association bp(GO:behavior) - pmid:27623715 + pubmed:28420982 - bp(MESH:"Oxidative Stress") increases a(CHEBI:"calcium(2+)") + p(HGNC:MAPT) decreases bp(GO:"synaptic signaling") - - - pmid:27623715 - - bp(MESH:"Oxidative Stress") decreases p(HGNC:S100B) - - - pmid:27623715 + pubmed:28420982 - bp(MESH:"Oxidative Stress") causesNoChange path(MESH:"Acidosis, Lactic") + p(HGNC:MAPT) association bp(GO:"intracellular signal transduction") - pmid:27623715 + pubmed:28420982 - bp(MESH:"Oxidative Stress") causesNoChange bp(GO:"amyloid fibril formation") + tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"cell body")) association bp(MESH:Aging) - pmid:23722080 + pubmed:28420982 - bp(MESH:"Oxidative Stress") decreases a(GO:mitochondrion) + tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:dendrite)) association bp(MESH:Aging) - pmid:24355211 + pubmed:28420982 - bp(MESH:"Oxidative Stress") positiveCorrelation p(HGNC:GSK3B) + tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association a(MESH:Exosomes) - pmid:8226987 + pubmed:29238289 - bp(MESH:"Oxidative Stress") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + p(HGNC:MAPT) association act(a(MESH:Exosomes)) - pmid:7667312 + pubmed:28420982 - bp(MESH:"Oxidative Stress") increases a(HBP:"paired helical filaments") + tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association a(GO:microvesicle) - pmid:28745240 + pubmed:28420982 - bp(GO:"JNK cascade") increases bp(GO:"apoptotic process") + p(HGNC:MAPT) increases a(CHEBI:"calcium(2+)") - - - pmid:28745240 - - bp(GO:"JNK cascade") increases act(complex(GO:"NF-kappaB complex")) - + - - - pmid:21722302 - - bp(GO:"JNK cascade") increases bp(GO:autophagy) - + - - - pmid:21722302 - - bp(GO:"JNK cascade") regulates bp(GO:autophagy) - + - - - pmid:21722302 - - bp(GO:"JNK cascade") increases p(HGNC:BCL2, pmod(Ph)) - + - - - pmid:21722302 - - bp(GO:"JNK cascade") negativeCorrelation p(MESH:"parkin protein") - + - - - pmid:28745240 - - bp(GO:"Fas signaling pathway") increases bp(GO:"apoptotic process") - + - - - pmid:28745240 - - bp(GO:"Fas signaling pathway") increases act(complex(GO:"NF-kappaB complex")) - + - - - pmid:28745240 - - p(HGNC:BCL2L1) increases sec(a(PUBCHEM:16057918)) - + - - - pmid:28745240 - - p(HGNC:BCL2L1) decreases bp(GO:"apoptotic process") - + - - - pmid:30444369 - - p(HGNC:BCL2L1) decreases bp(GO:"apoptotic process") - + - - - pmid:25652642 - - act(p(HGNC:BCL2L1)) decreases act(a(CHEBI:"amyloid-beta")) - + - pmid:28745240 + pubmed:16566606 - p(HGNC:BCL2) decreases bp(GO:"apoptotic process") + act(p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 394)) - - - pmid:30444369 - - p(HGNC:BCL2) decreases bp(GO:"apoptotic process") - + - - - pmid:21722302 - - p(HGNC:BCL2) association bp(MESH:"Endoplasmic Reticulum Stress") - + - pmid:21722302 + pubmed:26751493 - p(HGNC:BCL2) decreases bp(MESH:Apoptosis) + p(HGNC:MAPT) decreases act(p(HGNC:HDAC6)) - pmid:21722302 + pubmed:26751493 - p(HGNC:BCL2) decreases bp(MESH:Apoptosis) + p(HGNC:MAPT) regulates bp(MESH:"Transcription, Genetic") - pmid:21722302 + pubmed:26751493 - p(HGNC:BCL2) association bp(GO:"calcium ion homeostasis") + p(HGNC:MAPT) decreases bp(GO:autophagy) - - - pmid:23528736 - - p(HGNC:BCL2) decreases bp(GO:autophagy) - + - - - pmid:28745240 - - p(HGNC:BCL2A1) decreases bp(GO:"apoptotic process") - + - pmid:28745240 + pubmed:26751493 - a(CHEBI:etoposide) increases bp(GO:"apoptotic process") + p(HGNC:MAPT) positiveCorrelation bp(GO:"clathrin-dependent endocytosis") - - - pmid:29196815 - - a(MESH:"Amyloid beta-Peptides") positiveCorrelation path(MESH:"Alzheimer Disease") - - - pmid:22122372 + pubmed:27373205 - a(MESH:"Amyloid beta-Peptides") association path(MESH:"Alzheimer Disease") + p(HGNC:MAPT) increases a(CONSO:"Tau oligomers") - - - pmid:18650430 - - a(MESH:"Amyloid beta-Peptides") increases bp(GO:"cell adhesion") - + - - - pmid:22122372 - - a(MESH:"Amyloid beta-Peptides") association a(HBP:HBP00018) - + - - - pmid:11230871 - - a(MESH:"Amyloid beta-Peptides") negativeCorrelation p(FPLX:CHRN) - + - - - pmid:14556719 - - a(MESH:"Amyloid beta-Peptides") association path(MESH:"Plaque, Amyloid") - + - - - pmid:28745240 - - p(HGNC:SOD2) decreases bp(MESH:"Oxidative Stress") - + - pmid:28745240 + pubmed:16566606 - p(HGNC:SOD2) decreases bp(GO:"apoptotic process") + act(p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 18)) - - - pmid:25652642 - - act(p(HGNC:SOD2)) decreases act(a(CHEBI:"amyloid-beta")) - - - pmid:24563850 + pubmed:16566606 - p(HGNC:SOD2) increases rxn(reactants(a(CHEBI:superoxide)), products(a(CHEBI:"hydrogen peroxide"), a(CHEBI:dioxygen))) + act(p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) @@ -28187,277 +27988,243 @@

Statements

- - - - - - - - - pmid:28745240 + pubmed:26631930 - a(CHEBI:peroxynitrite) increases p(MESH:Proteins, pmod(HBP:nitration)) + tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) association path(CONSO:Neurodegeneration) - pmid:16566606 + pubmed:26631930 - a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(HBP:nitration)) + act(p(HGNC:MAPT)) association path(CONSO:Neurodegeneration) - pmid:21210655 + pubmed:26631930 - a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(HBP:formylation, Lys)) + p(HGNC:MAPT) association act(a(MESH:Dyneins)) - pmid:21210655 + pubmed:26631930 - a(CHEBI:peroxynitrite) increases bp(GO:"response to nitrosative stress") + p(HGNC:MAPT) association act(a(MESH:Kinesin)) - pmid:16816118 + pubmed:26631930 - a(CHEBI:peroxynitrite) increases p(RGD:Mapt, pmod(HBP:hyperphosphorylation)) + p(HGNC:MAPT) decreases complex(a(GO:microtubule), a(MESH:Dyneins)) - pmid:16816118 + pubmed:22817713 - a(CHEBI:peroxynitrite) increases p(RGD:Mapt, pmod(HBP:nitration)) + p(HGNC:MAPT) decreases complex(a(GO:microtubule), a(MESH:Dyneins)) - pmid:16816118 + pubmed:26631930 - a(CHEBI:peroxynitrite) increases act(p(RGD:Gsk3b)) + p(HGNC:MAPT) decreases complex(a(GO:microtubule), a(MESH:Kinesin)) - pmid:16816118 + pubmed:22817713 - a(CHEBI:peroxynitrite) increases act(p(RGD:Mapk14)) + p(HGNC:MAPT) decreases complex(a(GO:microtubule), a(MESH:Kinesin)) - pmid:16816118 + pubmed:26631930 - a(CHEBI:peroxynitrite) increases act(p(RGD:Mapk11)) + p(HGNC:MAPT) decreases bp(GO:"retrograde axonal transport") - pmid:16816118 + pubmed:26631930 - a(CHEBI:peroxynitrite) increases act(p(RGD:Mapk13)) + p(HGNC:MAPT) increases act(p(HGNC:GSK3B)) - pmid:16816118 + pubmed:26631930 - a(CHEBI:peroxynitrite) causesNoChange act(p(RGD:Mapk12)) + p(HGNC:MAPT) increases act(p(HGNC:PPP1R8)) - - - pmid:16816118 - - a(CHEBI:peroxynitrite) causesNoChange act(p(FPLX:ERK)) - - - pmid:16816118 + pubmed:26631930 - a(CHEBI:peroxynitrite) causesNoChange act(p(FPLX:JNK)) + p(HGNC:MAPT) directlyIncreases complex(p(HGNC:DCTN1), p(HGNC:MAPT)) - pmid:16816118 + pubmed:8391280 - a(CHEBI:peroxynitrite) increases a(HBP:"Tau aggregates") + p(HGNC:MAPT) isA complex(p(HGNC:DCTN1), p(HGNC:MAPT)) - pmid:16566606 + pubmed:26631930 - a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) + p(HGNC:MAPT) increases a(MESH:Neurites) - pmid:16566606 + pubmed:26631930 - a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) + p(HGNC:MAPT) association bp(GO:"regulation of synaptic plasticity") - pmid:16566606 + pubmed:26631930 - a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) + p(HGNC:MAPT) increases path(CONSO:Excitotoxicity) - pmid:16566606 + pubmed:26631930 - a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) + p(HGNC:MAPT) association bp(GO:neurogenesis) - pmid:16566606 + pubmed:26631930 - a(CHEBI:peroxynitrite) increases a(HBP:"3-3 dityrosine cross-linking") + p(HGNC:MAPT) association bp(GO:neurogenesis) - pmid:27314526 + pubmed:26631930 - a(CHEBI:peroxynitrite) increases bp(GO:"DNA conformation change") + p(HGNC:MAPT) decreases a(CHEBI:"iron(0)") - pmid:27314526 + pubmed:26631930 - a(CHEBI:peroxynitrite) decreases bp(GO:"energy reserve metabolic process") + p(HGNC:MAPT) decreases a(CHEBI:"iron(0)") - - - - - pmid:28745240 + pubmed:26631930 - composite(a(CHEBI:"kainic acid"), complex(GO:"NF-kappaB complex")) regulates bp(MESH:Neuroprotection) + p(HGNC:MAPT) increases bp(GO:locomotion) - pmid:28745240 + pubmed:26631930 - composite(a(CHEBI:"kainic acid"), complex(GO:"NF-kappaB complex")) decreases path(MESH:Ischemia) + p(HGNC:MAPT) increases tloc(p(HGNC:APP), fromLoc(GO:cytoplasm), toLoc(GO:"cell surface")) - pmid:19293145 + pubmed:26631930 - bp(MESH:Neuroprotection) association p(HGNC:FYN) + p(HGNC:MAPT) increases bp(GO:"long-term synaptic depression") - pmid:19293145 + pubmed:26631930 - bp(MESH:Neuroprotection) association bp(GO:"calcium-mediated signaling") + p(HGNC:MAPT) association bp(GO:"long-term synaptic depression") - - - pmid:19293145 - - bp(MESH:Neuroprotection) association a(MESH:Calcineurin) - - - pmid:19293145 + pubmed:26631930 - bp(MESH:Neuroprotection) association p(HGNC:JAK2) + p(HGNC:MAPT) directlyIncreases complex(a(MESH:Actins), p(HGNC:MAPT)) - - - pmid:19721446 - - bp(MESH:Neuroprotection) association p(HGNC:CHRNA7) - + - - - pmid:19721446 - - bp(MESH:Neuroprotection) association a(CHEBI:nicotine) - + + + @@ -28467,2059 +28234,2335 @@

Statements

- pmid:28745240 + pubmed:26631930 - composite(a(CHEBI:"linolenic acid"), complex(GO:"NF-kappaB complex")) regulates bp(MESH:Neuroprotection) + p(HGNC:MAPT) increases act(a(MESH:Brain)) - pmid:28745240 + pubmed:26631930 - composite(a(CHEBI:"linolenic acid"), complex(GO:"NF-kappaB complex")) decreases path(MESH:Ischemia) + p(HGNC:MAPT) decreases path(MESH:Dementia) - pmid:24653673 + pubmed:26631930 - bp(GO:neurogenesis) negativeCorrelation act(p(HGNC:GSK3B)) + p(HGNC:MAPT) association bp(GO:"iron ion transport") - pmid:24653673 + pubmed:26631930 - bp(GO:neurogenesis) negativeCorrelation act(p(HGNC:CDK5)) + p(HGNC:MAPT) association bp(GO:"DNA protection") - pmid:24653673 + pubmed:26631930 - bp(GO:neurogenesis) negativeCorrelation act(p(FPLX:ERK)) + tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) regulates act(a(CHEBI:amyloid-beta)) - pmid:26631930 + pubmed:26631930 - bp(GO:neurogenesis) association p(HGNC:MAPT) + tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) increases tloc(p(HGNC:TTLL6), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) - pmid:28745240 + pubmed:26631930 - p(HGNC:FGF2) increases act(complex(GO:"NF-kappaB complex")) + p(HGNC:MAPT) increases complex(p(HGNC:DLG4), p(HGNC:FYN)) - pmid:28745240 + pubmed:22817713 - p(HGNC:EGF) increases act(complex(GO:"NF-kappaB complex")) + p(HGNC:MAPT) association bp(GO:"regulation of microtubule cytoskeleton organization") + + - pmid:28745240 + pubmed:29626319 - p(HGNC:VEGFA) increases act(complex(GO:"NF-kappaB complex")) + p(HGNC:MAPT) decreases p(HGNC:PSMD7) - pmid:26304819 + pubmed:29238289 - p(HGNC:VEGFA) biomarkerFor path(MESH:"Alzheimer Disease") + p(HGNC:MAPT) association a(MESH:Microtubules) - pmid:28745240 + pubmed:29238289 - path(MESH:"Cerebral Infarction") increases act(complex(GO:"NF-kappaB complex")) + p(HGNC:MAPT, loc(GO:"extracellular region")) increases path(MESH:"Cytotoxicity, Immunologic") + + - pmid:28745240 + pubmed:29238289 - path(MESH:"Cerebral Infarction") increases bp(GO:neurogenesis) + tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association p(HGNC:RAB7A) - pmid:28745240 + pubmed:29238289 - path(MESH:"Brain Injuries, Traumatic") increases act(complex(GO:"NF-kappaB complex")) + tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association p(HGNC:RAB1A) - pmid:28745240 + pubmed:29238289 - path(MESH:"Brain Injuries, Traumatic") increases bp(GO:neurogenesis) + tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association a(MESH:"Transport Vesicles") + + + + + + + + + + + + + + + + + + + + - pmid:21722302 + pubmed:1918161 - path(MESH:"Brain Injuries, Traumatic") association bp(HBP:"protein aggregation") + p(HGNC:MAPT) directlyIncreases complex(GO:microtubule, loc(GO:"axon cytoplasm")) - pmid:30126037 + pubmed:10464280 - path(MESH:"Brain Injuries, Traumatic") association p(HGNC:MAPT) + p(HGNC:MAPT) association complex(GO:microtubule) + + - pmid:29626319 + pubmed:1918161 - path(MESH:"Brain Injuries, Traumatic") increases p(HGNC:MAPT) + p(HGNC:MAPT) positiveCorrelation complex(GO:axon) - pmid:26195256 + pubmed:1918161 - path(MESH:"Brain Injuries, Traumatic") association p(HBP:"tau aggregates") + p(HGNC:MAPT) positiveCorrelation complex(GO:"neuron projection") - pmid:29626319 + pubmed:17187063 - path(MESH:"Brain Injuries, Traumatic") decreases p(HGNC:AQP4) + p(HGNC:MAPT) directlyIncreases complex(GO:"actin filament bundle") - pmid:29626319 + pubmed:6543144 - path(MESH:"Brain Injuries, Traumatic") decreases act(p(HGNC:AQP4)) + p(HGNC:MAPT) association complex(GO:neurofilament) + + + + - pmid:29626319 + pubmed:11812770 - path(MESH:"Brain Injuries, Traumatic") decreases p(HGNC:AQP4) + p(HGNC:MAPT) positiveCorrelation complex(p(HGNC:GSK3B), p(HGNC:MAPT)) + + + + + + - pmid:29626319 + pubmed:18680553 - path(MESH:"Brain Injuries, Traumatic") decreases a(HP:"glymphatic system") + p(HGNC:MAPT) association bp(GO:myelination) - pmid:29626319 + pubmed:18467332 - path(MESH:"Brain Injuries, Traumatic") decreases a(HP:"glymphatic system") + p(HGNC:MAPT) association p(HGNC:SRC, frag("84_145")) + + - pmid:24561250 + pubmed:18467332 - path(MESH:"Brain Injuries, Traumatic") increases bp(GO:"cell death") + p(HGNC:MAPT) isA complex(p(HGNC:MAPT), p(HGNC:SRC)) - pmid:28745240 + pubmed:18467332 - a(CHEBI:"reactive oxygen species") increases act(complex(GO:"NF-kappaB complex")) + p(HGNC:MAPT) association p(HGNC:PLCG1, frag("790_851")) + + - pmid:28745240 + pubmed:18467332 - a(CHEBI:"reactive oxygen species") increases bp(GO:neurogenesis) + p(HGNC:MAPT) isA complex(p(HGNC:MAPT), p(HGNC:PLCG1)) - pmid:29179999 + pubmed:18467332 - a(CHEBI:"reactive oxygen species") increases act(p(FPLX:PKC)) + p(HGNC:MAPT) association p(HGNC:GRB2, frag("1_57")) + + - pmid:29179999 + pubmed:18467332 - a(CHEBI:"reactive oxygen species") increases act(p(FPLX:ERK)) + p(HGNC:MAPT) association complex(p(HGNC:GRB2), p(HGNC:MAPT)) - pmid:29179999 + pubmed:18467332 - a(CHEBI:"reactive oxygen species") increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) + p(HGNC:MAPT) association p(HGNC:PIK3R1, frag("3_79")) + + - pmid:27288790 + pubmed:18467332 - a(CHEBI:"reactive oxygen species") increases act(p(FPLX:NFkappaB)) + p(HGNC:MAPT) isA complex(p(HGNC:MAPT), p(HGNC:PIK3R1)) + + - pmid:27288790 + pubmed:10464280 - a(CHEBI:"reactive oxygen species") regulates act(p(FPLX:NFkappaB)) + p(HGNC:MAPT) increases complex(complex(GO:microtubule), p(HGNC:MAPT)) + + + + + + - pmid:27288790 + pubmed:17954934 - a(CHEBI:"reactive oxygen species") increases act(p(FPLX:"IKK_complex")) + p(HGNC:MAPT) isA complex(p(HGNC:BAG1), p(HGNC:HSPA8), p(HGNC:MAPT)) - pmid:27288790 + pubmed:17954934 - a(CHEBI:"reactive oxygen species") positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAPT) positiveCorrelation p(HGNC:BAG1) - pmid:27288790 + pubmed:8391280 - a(CHEBI:"reactive oxygen species") association bp(MESH:"Membrane Fluidity") + p(HGNC:MAPT) increases act(p(INTERPRO:"Dynein associated protein")) + + + + - pmid:27288790 + pubmed:21367866 - a(CHEBI:"reactive oxygen species") association bp(GO:"ion transport") + deg(p(HGNC:MAPT)) negativeCorrelation complex(p(FPLX:HSP90), p(HGNC:CDC37)) + + - pmid:27288790 + pubmed:2123288 - a(CHEBI:"reactive oxygen species") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + p(HGNC:MAPT) isA complex(p(FPLX:CALM), p(HGNC:MAPT)) + + - pmid:27288790 + pubmed:2123288 - a(CHEBI:"reactive oxygen species") decreases bp(GO:autophagy) + act(p(HGNC:MAPT)) negativeCorrelation complex(a(CHEBI:"calcium(2+)"), p(FPLX:CALM), p(HGNC:MAPT)) - pmid:24563850 + pubmed:2833519 - a(CHEBI:"reactive oxygen species") regulates bp(GO:autophagy) + p(HGNC:MAPT) association p(HGNC:S100B) + + - pmid:23528736 + pubmed:2833519 - a(CHEBI:"reactive oxygen species") negativeCorrelation bp(GO:autophagy) + p(HGNC:MAPT) isA complex(p(HGNC:MAPT), p(HGNC:S100B)) + + + + - pmid:27288790 + pubmed:12551948 - a(CHEBI:"reactive oxygen species") increases p(HGNC:NFKBIA, pmod(Ph)) + p(HGNC:MAPT) isA complex(p(HGNC:GSK3B), p(HGNC:MAPT), p(HGNC:YWHAZ)) - pmid:30061532 + pubmed:12551948 - a(CHEBI:"reactive oxygen species") association path(MESH:Schizophrenia) + p(HGNC:MAPT) association p(HGNC:YWHAZ) - pmid:24563850 + pubmed:21339331 - a(CHEBI:"reactive oxygen species") increases bp(GO:"negative regulation of inflammatory response") + p(HGNC:MAPT) association p(HGNC:ANXA2) + + - pmid:24563850 + pubmed:21339331 - a(CHEBI:"reactive oxygen species") regulates bp(GO:"response to hypoxia") + p(HGNC:MAPT) isA complex(p(HGNC:ANXA2), p(HGNC:MAPT)) + + - pmid:24563850 + pubmed:21131359 - a(CHEBI:"reactive oxygen species") regulates bp(GO:"leukocyte activation") + p(HGNC:MAPT) isA complex(a(CHEBI:"double-stranded DNA"), p(HGNC:MAPT)) - pmid:24563850 + pubmed:21131359 - a(CHEBI:"reactive oxygen species") regulates bp(GO:"cell differentiation") + p(HGNC:MAPT) association a(CHEBI:"double-stranded DNA") - pmid:24563850 + pubmed:21131359 - a(CHEBI:"reactive oxygen species") regulates bp(GO:"integrin activation") + p(HGNC:MAPT) negativeCorrelation bp(MESH:"Hot Temperature") + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - pmid:28528849 + pubmed:16566606 - a(CHEBI:"reactive oxygen species") increases act(complex(GO:"NADPH oxidase complex")) + act(p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 197)) - pmid:16566606 + pubmed:16566606 - a(CHEBI:"reactive oxygen species") decreases act(a(MESH:Neurons)) + p(HGNC:MAPT) increases bp(GO:"tubulin complex assembly") + + + + + + + + + + - pmid:16566606 + pubmed:24869773 - a(CHEBI:"reactive oxygen species") increases bp(GO:"neuron death") + p(HGNC:MAPT) association p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 24)) + + - pmid:23702978 + pubmed:24869773 - a(CHEBI:"reactive oxygen species") increases act(p(HGNC:TRPM2)) + p(HGNC:MAPT) association p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 44)) + + - pmid:23702978 + pubmed:24869773 - a(CHEBI:"reactive oxygen species") increases bp(GO:"apoptosome assembly") + p(HGNC:MAPT) association p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 67)) + + - pmid:28745240 + pubmed:24869773 - path(MESH:Hypoxia) increases act(complex(GO:"NF-kappaB complex")) + p(HGNC:MAPT) association p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 190)) + + + + + + + + + + + + + + + + + + + + + + + + - pmid:28745240 + pubmed:19251756 - path(MESH:Hypoxia) increases bp(GO:neurogenesis) + p(HGNC:MAPT) association p(INTERPRO:"Triosephosphate isomerase", pmod(go:0017014 ! "protein nitrosylation")) + + - pmid:21722302 + pubmed:19251756 - path(MESH:Hypoxia) increases act(p(HGNC:PRKAA1)) + p(HGNC:MAPT) partOf complex(p(HGNC:MAPT), p(INTERPRO:"Triosephosphate isomerase", pmod(go:0017014 ! "protein nitrosylation"))) - pmid:28745240 + pubmed:10537045 - p(HBP:"sAPP-alpha") increases act(complex(GO:"NF-kappaB complex")) + p(HGNC:MAPT) positiveCorrelation p(HGNC:TGM2) + + - pmid:28745240 + pubmed:10537045 - p(HBP:"sAPP-alpha") increases bp(GO:neurogenesis) + p(HGNC:MAPT) partOf complex(p(HGNC:MAPT), p(HGNC:TGM2)) + + + + + + + + + + + + + + + + - pmid:28745240 + pubmed:24853415 - a(CHEBI:"sphingosine 1-phosphate") increases act(complex(GO:"NF-kappaB complex")) + p(HGNC:MAPT) positiveCorrelation p(HGNC:DAPK1) - pmid:28745240 + pubmed:24853415 - a(CHEBI:"sphingosine 1-phosphate") increases bp(GO:neurogenesis) + p(HGNC:MAPT) positiveCorrelation p(HGNC:PIN1, pmod(go:0006468 ! "protein phosphorylation", Ser, 71)) + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - pmid:28745240 + pubmed:26091809 - a(CHEBI:"nitric oxide") decreases act(complex(GO:"NF-kappaB complex")) + p(HGNC:MAPT, loc(GO:"inclusion body")) decreases p(HGNC:TARDBP) - pmid:28745240 + pubmed:30988501 - a(CHEBI:"nitric oxide") decreases bp(GO:neurogenesis) + p(HGNC:MAPT) biomarkerFor path(DOID:"Alzheimer's disease") - pmid:29559585 + pubmed:25652642 - a(CHEBI:"nitric oxide") increases p(MGI:Gapdh, pmod(NO)) + a(GO:"neurofibrillary tangle") positiveCorrelation act(complex(GO:"NF-kappaB complex")) - pmid:27601475 + pubmed:29196815 - a(CHEBI:"nitric oxide") positiveCorrelation a(HBP:"8-nitro-cGMP") + a(GO:"neurofibrillary tangle") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:23702978 + pubmed:28420982 - a(CHEBI:"nitric oxide") increases p(HGNC:NLRP3, pmod(NO)) + a(GO:"neurofibrillary tangle") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27314526 + pubmed:22817713 - a(CHEBI:"nitric oxide") increases a(CHEBI:peroxynitrite) + a(GO:"neurofibrillary tangle") association path(MESH:"Alzheimer Disease") - pmid:27314526 + pubmed:11089576 - a(CHEBI:"nitric oxide") increases act(p(HGNC:CASP3)) + a(GO:"neurofibrillary tangle") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27314526 + pubmed:21156028 - a(CHEBI:"nitric oxide") increases p(HGNC:MAPT, pmod(Ph)) + a(GO:"neurofibrillary tangle") increases bp(GO:"neuron death") - pmid:27314526 + pubmed:24653673 - a(CHEBI:"nitric oxide") increases bp(GO:"p38MAPK cascade") + a(GO:"neurofibrillary tangle") association p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation", Tyr, 307)) - pmid:28745240 + pubmed:29758300 - path(HP:"Ischemic stroke") increases act(complex(GO:"NF-kappaB complex")) + a(GO:"neurofibrillary tangle") association p(HGNC:BECN1, frag("?")) - pmid:28745240 + pubmed:22908190 - path(HP:Seizures) increases act(complex(GO:"NF-kappaB complex")) + a(GO:"neurofibrillary tangle") association a(CONSO:"paired helical filaments") - pmid:28745240 + pubmed:22908190 - a(MESH:"Cerebral Cortex") negativeCorrelation act(complex(GO:"NF-kappaB complex")) + a(GO:"neurofibrillary tangle") association a(MESH:Ubiquitin) - pmid:24511233 + pubmed:22908190 - a(MESH:"Cerebral Cortex") association bp(GO:cognition) + a(GO:"neurofibrillary tangle") negativeCorrelation act(complex(GO:"proteasome complex")) - pmid:24511233 + pubmed:22908190 - a(MESH:"Cerebral Cortex") association bp(GO:learning) + a(GO:"neurofibrillary tangle") negativeCorrelation p(HGNC:UCHL1, pmod(GO:"protein oxidation")) - pmid:24511233 + pubmed:22908190 - a(MESH:"Cerebral Cortex") association bp(GO:learning) + a(GO:"neurofibrillary tangle") association bp(GO:"protein K63-linked ubiquitination") - pmid:24511233 + pubmed:22908190 - a(MESH:"Cerebral Cortex") association bp(GO:memory) + a(GO:"neurofibrillary tangle") association p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:24511233 + pubmed:18930136 - a(MESH:"Cerebral Cortex") association bp(GO:memory) + a(GO:"neurofibrillary tangle") association p(HGNC:SQSTM1) - pmid:24590577 + pubmed:27671637 - a(MESH:"Cerebral Cortex") association p(HGNC:CHRM1) + a(GO:"neurofibrillary tangle") positiveCorrelation p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) - pmid:26195256 + pubmed:30126037 - a(MESH:"Cerebral Cortex") negativeCorrelation path(MESH:"Alzheimer Disease") + a(GO:"neurofibrillary tangle") decreases bp(GO:cognition) - pmid:28745240 + pubmed:30126037 - p(HGNC:IL6) increases bp(GO:"astrocyte development") + a(GO:"neurofibrillary tangle") increases bp(GO:"cell death") - pmid:28745240 + pubmed:30126037 - p(HGNC:IL6) increases p(HGNC:STAT3) + a(GO:"neurofibrillary tangle") decreases bp(GO:"cell death") - pmid:28745240 + pubmed:30126037 - p(HGNC:IL6) increases a(MESH:"Transcription Factor AP-1") + a(GO:"neurofibrillary tangle") positiveCorrelation p(MGI:Cdkn2a) - pmid:28745240 + pubmed:30126037 - p(HGNC:IL6) increases act(complex(GO:"NF-kappaB complex")) + a(GO:"neurofibrillary tangle") increases act(p(MGI:Cdkn2a)) - pmid:28745240 + pubmed:30126037 - p(HGNC:IL6) association path(MESH:"Alzheimer Disease") + a(GO:"neurofibrillary tangle") increases p(MGI:Cdkn2a) - pmid:25652642 + pubmed:30126037 - p(HGNC:IL6) positiveCorrelation path(MESH:"Alzheimer Disease") + a(GO:"neurofibrillary tangle") increases p(MGI:Cdkn2a) - pmid:28745240 + pubmed:30126037 - p(HGNC:IL6) increases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) + a(GO:"neurofibrillary tangle") association bp(GO:"cellular senescence") - pmid:28745240 + pubmed:30126037 - p(HGNC:IL6) increases bp(GO:"neuron death") + a(GO:"neurofibrillary tangle") increases bp(MESH:"Cell Survival") - pmid:28745240 + pubmed:30126037 - a(MESH:"Transcription Factor AP-1") increases bp(GO:"astrocyte development") + a(GO:"neurofibrillary tangle") increases bp(GO:"inflammatory response") - pmid:28745240 + pubmed:30126037 - p(HGNC:LIF) increases bp(GO:"astrocyte development") + a(GO:"neurofibrillary tangle") increases bp(GO:"cell cycle") - pmid:28745240 + pubmed:30126037 - p(HGNC:LIF) increases p(HGNC:STAT3) + a(GO:"neurofibrillary tangle") decreases bp(GO:"apoptotic process") - pmid:28745240 + pubmed:30126037 - p(HGNC:LIF) increases a(MESH:"Transcription Factor AP-1") + a(GO:"neurofibrillary tangle") decreases path(MESH:Necrosis) - pmid:28745240 + pubmed:30126037 - p(HGNC:LIF) increases act(complex(GO:"NF-kappaB complex")) + a(GO:"neurofibrillary tangle") increases p(HGNC:NFKB1) - pmid:28745240 + pubmed:30126037 - p(HGNC:CNTF) increases bp(GO:"astrocyte development") + a(GO:"neurofibrillary tangle") increases p(HGNC:IFNG) - pmid:28745240 + pubmed:30126037 - p(HGNC:CNTF) increases p(HGNC:STAT3) + a(GO:"neurofibrillary tangle") increases p(HGNC:TNF) - pmid:28745240 + pubmed:30126037 - p(HGNC:CNTF) increases a(MESH:"Transcription Factor AP-1") + a(GO:"neurofibrillary tangle") increases p(HGNC:TLR4) - pmid:28745240 + pubmed:30126037 - p(HGNC:CNTF) increases act(complex(GO:"NF-kappaB complex")) + a(GO:"neurofibrillary tangle") increases p(HGNC:IL1B) - pmid:28745240 + pubmed:30126037 - p(HGNC:CNTF) increases act(complex(GO:"NF-kappaB complex")) + a(GO:"neurofibrillary tangle") increases p(HGNC:CXCL1) - pmid:28745240 + pubmed:30126037 - p(HGNC:CNTF) increases bp(MESH:"Neuronal Outgrowth") + a(GO:"neurofibrillary tangle") increases act(p(MGI:Ifng)) - pmid:28745240 + pubmed:30126037 - p(HGNC:CNTF) increases act(p(HGNC:LCK)) + a(GO:"neurofibrillary tangle") increases act(p(MGI:Tnf)) - pmid:28745240 + pubmed:30126037 - bp(MESH:"Neuronal Outgrowth") negativeCorrelation p(HGNC:RELA, pmod(Ph, Ser, 536)) + a(GO:"neurofibrillary tangle") increases act(p(MGI:Il1b)) - pmid:27288790 + pubmed:30126037 - bp(MESH:"Neuronal Outgrowth") association p(FPLX:NFkappaB) + a(GO:"neurofibrillary tangle") increases act(p(MGI:Jak1)) - pmid:21214928 + pubmed:30126037 - bp(MESH:"Neuronal Outgrowth") association p(HGNC:APP) + a(GO:"neurofibrillary tangle") increases act(p(MGI:Stat1)) - pmid:23383175 + pubmed:30126037 - act(a(GO:axon)) decreases path(MESH:Paralysis) + a(GO:"neurofibrillary tangle") increases act(p(MGI:Bcl2)) - pmid:23383175 + pubmed:30126037 - act(a(GO:axon)) decreases path(HP:"Limb muscle weakness") + a(GO:"neurofibrillary tangle") association p(HGNC:CDKN2A) - pmid:27807169 + pubmed:30126037 - a(GO:axon) positiveCorrelation p(RGD:Cdk5r2) + a(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:CDKN2A) - pmid:28745240 + pubmed:30126037 - p(HGNC:BDNF) increases bp(MESH:"Neuronal Outgrowth") + a(GO:"neurofibrillary tangle") increases p(HGNC:CDKN2A) - pmid:28745240 + pubmed:30126037 - p(HGNC:BDNF) increases act(complex(GO:"NF-kappaB complex")) + a(GO:"neurofibrillary tangle") decreases bp(GO:"oxygen transport") - pmid:28745240 + pubmed:30126037 - p(HGNC:BDNF) increases act(p(HGNC:SRC)) + a(GO:"neurofibrillary tangle") association path(MESH:"Hypertrophy, Right Ventricular") - pmid:22040696 + pubmed:30126037 - p(HGNC:BDNF) regulates bp(GO:"peripheral nervous system development") + a(GO:"neurofibrillary tangle") association path(MESH:"Hypertrophy, Left Ventricular") - pmid:22040696 + pubmed:30126037 - p(HGNC:BDNF) regulates bp(GO:"central nervous system development") + a(GO:"neurofibrillary tangle") association path(HP:"Brain atrophy") - pmid:22040696 + pubmed:30985105 - p(HGNC:BDNF) increases bp(GO:"regulation of synaptic plasticity") + deg(a(GO:"neurofibrillary tangle")) negativeCorrelation p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) - pmid:22040696 + pubmed:26751493 - p(HGNC:BDNF) increases bp(GO:"spontaneous synaptic transmission") + a(GO:"neurofibrillary tangle") negativeCorrelation r(HGNC:SYP) - pmid:22040696 + pubmed:26751493 - p(HGNC:BDNF) increases bp(GO:"synaptic transmission, GABAergic") + a(GO:"neurofibrillary tangle") negativeCorrelation p(HGNC:SNAP25) - pmid:22040696 + pubmed:26751493 - p(HGNC:BDNF) increases bp(GO:"maintenance of synapse structure") + a(GO:"neurofibrillary tangle") negativeCorrelation p(PFAM:Syntaxin) - pmid:22040696 + pubmed:23531502 - p(HGNC:BDNF) association p(HGNC:CHRNA7) + a(GO:"neurofibrillary tangle") association act(a(CHEBI:acrolein)) - pmid:22040696 + pubmed:12578227 - p(HGNC:BDNF) increases p(HGNC:CHRNA7) + a(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:TGM1) - pmid:22040696 + pubmed:12578227 - p(HGNC:BDNF) increases surf(p(HGNC:CHRNA7)) + a(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:TGM2) - pmid:30985105 + pubmed:11089576 - p(HGNC:BDNF) association p(HGNC:HTT) + a(GO:"neurofibrillary tangle") positiveCorrelation act(p(ECCODE:2.3.2.13)) - pmid:28632203 + pubmed:11738469 - p(HGNC:BDNF) biomarkerFor path(MESH:"Alzheimer Disease") + a(GO:"neurofibrillary tangle") positiveCorrelation act(p(ECCODE:2.3.2.13)) - pmid:28745240 + pubmed:8985134 - act(p(HGNC:SRC)) increases p(HGNC:NFKBIA, pmod(Ph, Tyr, 42)) + a(GO:"neurofibrillary tangle") positiveCorrelation act(p(ECCODE:2.3.2.13)) - pmid:19293145 + pubmed:11089576 - p(HGNC:SRC) increases bp(MESH:Neuroprotection) + a(GO:"neurofibrillary tangle") positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") - pmid:24653673 + pubmed:9099822 - p(HGNC:SRC) increases p(HGNC:PPP2CA, pmod(Ph, Tyr, 307)) + a(GO:"neurofibrillary tangle") positiveCorrelation act(p(HGNCGENEFAMILY:Transglutaminases)) - pmid:24653673 + pubmed:23088643 - p(HGNC:SRC) increases p(HGNC:PPP2CA, pmod(Ph, Tyr, 307)) + a(GO:"neurofibrillary tangle") association p(CONSO:"Tau epitope, AT8") - pmid:24653673 + pubmed:23088643 - p(HGNC:SRC) increases p(HGNC:PPP2CB, pmod(Ph, Tyr, 307)) + a(GO:"neurofibrillary tangle") association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) - pmid:24653673 + pubmed:26751493 - p(HGNC:SRC) increases p(HGNC:PPP2CB, pmod(Ph, Tyr, 307)) + a(GO:"neurofibrillary tangle") negativeCorrelation p(INTERPRO:"Syntaxin, N-terminal domain") - pmid:29191965 + pubmed:26118667 - p(HGNC:SRC) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr)) + a(GO:"neurofibrillary tangle") positiveCorrelation p(CONSO:"CDK5R1 p25") - pmid:26751493 + pubmed:29844403 - p(HGNC:SRC) association p(HBP:"projection domain") + a(GO:"neurofibrillary tangle") positiveCorrelation a(CONSO:"Tau aggregates") - - - pmid:18467332 + pubmed:21734277 - p(HGNC:SRC) isA complex(p(HGNC:MAPT), p(HGNC:SRC)) + a(GO:"neurofibrillary tangle") decreases bp(GO:"axonal transport") - pmid:28745240 + pubmed:21734277 - p(HGNC:NFKBIA, pmod(Ph, Tyr, 42)) increases act(complex(GO:"NF-kappaB complex")) + a(GO:"neurofibrillary tangle") increases act(p(FPLX:PPP1)) - pmid:28745240 + pubmed:21734277 - act(p(HGNC:LCK)) increases p(HGNC:NFKBIA, pmod(Ph, Tyr, 42)) + a(GO:"neurofibrillary tangle") increases act(p(HGNC:GSK3B)) - pmid:30640040 + pubmed:23832849 - p(HGNC:LCK) association a(PUBCHEM:4878) + a(GO:"neurofibrillary tangle") association p(HGNC:FKBP1A) - pmid:29191965 + pubmed:30663117 - p(HGNC:LCK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr)) + g(HGNC:MIR9-1) decreases a(GO:"neurofibrillary tangle") - pmid:26751493 + pubmed:30663117 - p(HGNC:LCK) association p(HBP:"projection domain") + g(HGNC:MIR9-1) decreases act(p(HGNC:MAP2K2)) - pmid:26631930 + pubmed:30663117 - p(HGNC:LCK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 18)) + g(HGNC:MIR9-1) association path(MESH:"Alzheimer Disease") - pmid:28745240 + pubmed:30663117 - p(HGNC:RELA, pmod(Ph, Ser, 536)) negativeCorrelation bp(MESH:"Neuronal Outgrowth") + act(p(HGNC:MAP2K2)) increases a(GO:"neurofibrillary tangle") - pmid:28745240 + pubmed:30663117 - bp(GO:"axon guidance") increases bp(GO:neurogenesis) + a(MESH:"RNA, Long Noncoding") increases bp(GO:"apoptotic process") - pmid:28745240 + pubmed:28745240 - bp(GO:"axon guidance") increases a(GO:axon) + bp(GO:"apoptotic process") negativeCorrelation p(HGNC:RELA) - pmid:28745240 + pubmed:27288790 - p(HGNC:ITGB1) increases bp(GO:"axon guidance") + bp(GO:"apoptotic process") association p(FPLX:NFkappaB) - pmid:28745240 + pubmed:22236693 - p(HGNC:ITGB1) increases a(GO:axon) + bp(GO:"apoptotic process") negativeCorrelation p(HGNC:NTRK1) - pmid:21214928 + pubmed:20100581 - p(HGNC:ITGB1) association p(HGNC:APP) + bp(GO:"apoptotic process") association bp(GO:"microglial cell activation") - pmid:28745240 + pubmed:20100581 - p(HGNC:NCAM1) increases a(GO:axon) + bp(GO:"apoptotic process") association a(NIFT:"Hippocampal atrophy") - pmid:28745240 + pubmed:19293145 - p(HGNC:SLITRK1) increases a(GO:axon) + bp(GO:"apoptotic process") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:28745240 + pubmed:18986241 - p(HGNC:GFRA1) increases a(GO:axon) + bp(GO:"apoptotic process") association bp(GO:"MAPK cascade") - pmid:28745240 + pubmed:24653673 - p(HGNC:TIAM1) increases a(GO:axon) + bp(GO:"apoptotic process") positiveCorrelation act(p(HGNC:GSK3B)) - - - pmid:22020111 + pubmed:24653673 - act(a(MESH:"Dendritic Cells")) increases bp(GO:"T cell activation") + bp(GO:"apoptotic process") positiveCorrelation act(p(HGNC:CDK5)) - pmid:28745240 + pubmed:24653673 - p(HGNC:HES1) increases a(GO:"dendritic branch") + bp(GO:"apoptotic process") positiveCorrelation act(p(FPLX:ERK)) - pmid:28745240 + pubmed:30012004 - p(HGNC:HES1) increases a(MESH:"Dendritic Cells") + bp(GO:"apoptotic process") positiveCorrelation path(MESH:"Huntington Disease") - pmid:28745240 + pubmed:24563850 - p(HGNC:HES5) increases a(GO:"dendritic branch") + bp(GO:"apoptotic process") increases bp(GO:"cell death") - pmid:28745240 + pubmed:24027553 - p(HGNC:HES5) increases a(MESH:"Dendritic Cells") + bp(GO:"apoptotic process") increases act(p(HGNCGENEFAMILY:Calpains)) - pmid:28745240 + pubmed:24027553 - p(HGNC:MAP1B) increases a(MESH:"Dendritic Cells") + bp(GO:"apoptotic process") increases p(HGNC:MAPT, frag("?", "17kD")) - pmid:28745240 + pubmed:24027553 - p(HGNC:MAP2) increases a(MESH:"Dendritic Cells") + bp(GO:"apoptotic process") increases act(p(HGNC:CASP6)) - pmid:30061532 + pubmed:26304819 - p(HGNC:MAP2) increases a(GO:microtubule) + bp(GO:"apoptotic process") association r(HGNC:GAPDH) - pmid:30061532 + pubmed:23948915 - p(HGNC:MAP2) increases bp(GO:"dendritic spine organization") + bp(GO:"apoptotic process") negativeCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) - pmid:30061532 + pubmed:23948915 - p(HGNC:MAP2) increases bp(GO:"cytoskeleton organization") + bp(GO:"apoptotic process") negativeCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) - - - - - - - - - pmid:28745240 + pubmed:23948915 - complex(a(GO:"membrane attack complex"), p(HGNC:C5)) increases act(complex(GO:"NF-kappaB complex")) + bp(GO:"apoptotic process") negativeCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) - pmid:28745240 + pubmed:30663117 - p(HGNC:IL1B) increases bp(GO:"neuron death") + g(HGNC:EBF3) isA a(MESH:"RNA, Long Noncoding") - pmid:27288790 + pubmed:30663117 - p(HGNC:IL1B) positiveCorrelation path(MESH:"Alzheimer Disease") + bp(GO:"neuron death") increases g(MGI:Ebf3) - pmid:25652642 + pubmed:27794524 - p(HGNC:IL1B) positiveCorrelation path(MESH:"Alzheimer Disease") + bp(GO:"neuron death") association path(MESH:"Oxidative Stress") - pmid:24561250 + pubmed:29661268 - p(HGNC:IL1B) positiveCorrelation path(MESH:"Alzheimer Disease") + bp(GO:"neuron death") negativeCorrelation p(HGNC:STUB1) - pmid:27314526 + pubmed:30444369 - p(HGNC:IL1B) positiveCorrelation path(MESH:"Alzheimer Disease") + bp(GO:"neuron death") association p(HGNC:SH3GL2) - pmid:27288790 + pubmed:29196815 - p(HGNC:IL1B) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) + bp(GO:"neuron death") positiveCorrelation a(CONSO:CONSO00074) - pmid:27288790 + pubmed:21214928 - p(HGNC:IL1B) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) + bp(GO:"neuron death") association complex(p(CONSO:CONSO00042), p(HGNC:TNFRSF21)) - pmid:27288790 + pubmed:22122372 - p(HGNC:IL1B) increases p(FPLX:"IKK_complex", pmod(Ph)) + bp(GO:"neuron death") association path(MESH:"Alzheimer Disease") - pmid:27288790 + pubmed:17009926 - p(HGNC:IL1B) increases p(HGNC:RELA, pmod(Ph)) + bp(GO:"neuron death") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27288790 + pubmed:17009926 - p(HGNC:IL1B) decreases p(FPLX:IKB) + bp(GO:"neuron death") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27288790 + pubmed:25514383 - p(HGNC:IL1B) increases a(MESH:Cytokines) + bp(GO:"neuron death") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27288790 + pubmed:21722302 - p(HGNC:IL1B) increases a(MESH:Chemokines) + bp(GO:"neuron death") prognosticBiomarkerFor path(MESH:"Alzheimer Disease") - pmid:23702978 + pubmed:28420982 - act(p(HGNC:IL1B)) increases bp(GO:"neutrophil activation") + bp(GO:"neuron death") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:24561250 + pubmed:26631930 - p(HGNC:IL1B) positiveCorrelation complex(GO:"inflammasome complex") + bp(GO:"neuron death") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:24561250 + pubmed:19625741 - p(HGNC:IL1B) increases bp(GO:"inflammatory response") + bp(GO:"neuron death") positiveCorrelation p(HGNC:GRN) - pmid:27314526 + pubmed:26235064 - p(HGNC:IL1B) positiveCorrelation path(MESH:Dementia) + bp(GO:"neuron death") association p(HGNC:MAPT) - pmid:27314526 + pubmed:22426017 - p(HGNC:IL1B) increases bp(GO:"microglial cell activation") + bp(GO:"neuron death") increases a(NIFT:"Cortical Thinning") - pmid:27314526 + pubmed:14970312 - p(HGNC:IL1B) increases bp(GO:"astrocyte activation") + bp(GO:"neuron death") increases a(NIFT:"Hippocampal atrophy") - pmid:27314526 + pubmed:14970312 - sec(p(HGNC:IL1B)) increases p(HGNC:APP) + bp(GO:"neuron death") increases a(NIFT:"Hippocampal atrophy") - pmid:27314526 + pubmed:21787755 - sec(p(HGNC:IL1B)) increases a(CHEBI:"amyloid-beta") + bp(GO:"neuron death") association p(CONSO:"alpha-7-containing nAChR") - pmid:28745240 + pubmed:23516100 - bp(GO:"p38MAPK cascade") increases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) + bp(GO:"neuron death") positiveCorrelation p(HGNC:ATXN3, frag("1_?")) - pmid:25514383 + pubmed:30012004 - bp(GO:"p38MAPK cascade") increases a(HBP:"Tau aggregates") + bp(GO:"neuron death") increases path(MESH:Atrophy) - pmid:27314526 + pubmed:30012004 - bp(GO:"p38MAPK cascade") increases complex(GO:"neurofibrillary tangle") + bp(GO:"neuron death") positiveCorrelation path(MESH:"Huntington Disease") - pmid:30145931 + pubmed:30012004 - p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) positiveCorrelation a(HBP:"amyloid-beta oligomers") + bp(GO:"neuron death") positiveCorrelation path(MESH:"Huntington Disease") - pmid:28784767 + pubmed:21861815 - p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) increases a(HBP:"Tau Protein Secondary Structure, Turn") + bp(GO:"neuron death") increases path(DOID:"amyotrophic lateral sclerosis") - pmid:21882945 + pubmed:21722302 - p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) positiveCorrelation path(MESH:"Alzheimer Disease") + bp(GO:"neuron death") association p(HGNC:PRNP) - - - pmid:26118667 + pubmed:29758300 - complex(p(HGNC:CDK5), p(HGNC:CDK5R1)) increases act(p(HGNC:CDK5)) + bp(GO:"neuron death") association path(MESH:"Neurodegenerative Diseases") - - - pmid:28745240 + pubmed:14556719 - act(complex(p(HGNC:CDK5), p(HGNC:CDK5R1))) increases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) + bp(GO:"neuron death") positiveCorrelation path(MESH:"Parkinson Disease") - pmid:30444369 + pubmed:22908190 - p(HGNC:CDK5) positiveCorrelation path(MESH:"Alzheimer Disease") + bp(GO:"neuron death") positiveCorrelation act(p(HGNC:RAB5A)) - pmid:24653673 + pubmed:24027553 - p(HGNC:CDK5) association path(MESH:"Alzheimer Disease") + bp(GO:"neuron death") negativeCorrelation bp(MESH:Autophagy) - pmid:8282104 + pubmed:21882945 - p(HGNC:CDK5) positiveCorrelation path(MESH:"Alzheimer Disease") + bp(GO:"neuron death") positiveCorrelation path(MESH:Tauopathies) - pmid:30444369 + pubmed:28420982 - p(HGNC:CDK5) increases p(HGNC:PRDX2, pmod(Ph, Thr, 89)) + bp(GO:"neuron death") association path(MESH:Tauopathies) - pmid:22122372 + pubmed:30663117 - p(HGNC:CDK5) increases p(HBP:HBP00071, pmod(Ph, Thr, 654)) + a(CONSO:"alpha-synuclein aggregates") association path(MESH:"Parkinson Disease") - pmid:22122372 + pubmed:30663117 - p(HGNC:CDK5) increases p(HBP:HBP00071, pmod(Ph, Thr, 668)) + a(CONSO:"alpha-synuclein aggregates") increases path(MESH:"Parkinson Disease") - pmid:22122372 + pubmed:30663117 - p(HGNC:CDK5) increases p(HBP:HBP00071, pmod(Ph, Ser, 665)) + a(CONSO:"alpha-synuclein aggregates") decreases a(MESH:"Dopaminergic Neurons") - pmid:30061532 + pubmed:30663117 - p(HGNC:CDK5) regulates p(HGNC:DPYSL2) + a(CONSO:"alpha-synuclein aggregates") negativeCorrelation a(MESH:"HSP70 Heat-Shock Proteins") - pmid:30061532 + pubmed:29758300 - p(HGNC:CDK5) positiveCorrelation a(GO:"dendritic spine") + a(CONSO:"alpha-synuclein aggregates") association path(MESH:"Alzheimer Disease") - pmid:30061532 + pubmed:29758300 - p(HGNC:CDK5) positiveCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + a(CONSO:"alpha-synuclein aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:25001178 + pubmed:14556719 - act(p(HGNC:CDK5), ma(kin)) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + a(CONSO:"alpha-synuclein aggregates") association a(MESH:"Lewy Bodies") - pmid:30061532 + pubmed:14556719 - act(p(HGNC:CDK5)) positiveCorrelation path(MESH:Schizophrenia) + a(CONSO:"alpha-synuclein aggregates") positiveCorrelation path(MESH:"Parkinsonian Disorders") + + - pmid:30061532 + pubmed:14556719 - act(p(HGNC:CDK5)) negativeCorrelation p(HGNC:CDK5R1) + a(CONSO:"alpha-synuclein aggregates") decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:24653673 + pubmed:30116051 - act(p(HGNC:CDK5)) negativeCorrelation a(GO:"microtubule cytoskeleton") + a(CONSO:"alpha-synuclein aggregates") decreases complex(GO:"proteasome complex") - pmid:24653673 + pubmed:30985105 - act(p(HGNC:CDK5)) negativeCorrelation a(GO:"neurofilament cytoskeleton") + a(CONSO:"alpha-synuclein aggregates") decreases bp(GO:"neuron death") - pmid:24653673 + pubmed:30985105 - act(p(HGNC:CDK5)) negativeCorrelation p(HGNC:APP, pmod(Ph)) + a(CONSO:"alpha-synuclein aggregates") negativeCorrelation a(CONSO:"alpha-synuclein oligomers") - pmid:24653673 + pubmed:30663117 - act(p(HGNC:CDK5)) negativeCorrelation bp(HBP:"APP processing") + p(HGNC:SNCA, pmod(CONSO:misfolded)) association path(MESH:"Parkinson Disease") - pmid:24653673 + pubmed:21722302 - act(p(HGNC:CDK5)) negativeCorrelation bp(GO:neurogenesis) + p(HGNC:SNCA, pmod(CONSO:misfolded)) increases a(CONSO:"alpha-synuclein aggregates") + + - pmid:24653673 + pubmed:30663117 - act(p(HGNC:CDK5)) positiveCorrelation bp(GO:"negative regulation of synaptic plasticity") + p(HGNC:SNCA) association bp(GO:"synaptic transmission, dopaminergic") + + - pmid:24653673 + pubmed:30663117 - act(p(HGNC:CDK5)) positiveCorrelation bp(GO:"apoptotic process") + p(HGNC:SNCA) positiveCorrelation a(GO:"Lewy body", loc(MESH:"Dopaminergic Neurons")) - pmid:12428809 + pubmed:30962309 - p(HGNC:CDK5) increases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:SNCA) increases act(complex(GO:"NLRP3 inflammasome complex")) - pmid:29758300 + pubmed:30962309 - p(HGNC:CDK5) increases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:SNCA) increases act(p(HGNC:IL1B)) - pmid:8282104 + pubmed:30962309 - p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:SNCA) increases path(DOID:"neurodegenerative disease") + + + + + + + + + + + + + + + + + + + + + + + + - pmid:21882945 + pubmed:30688256 - act(p(HGNC:CDK5)) directlyIncreases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:SNCA) decreases bp(GO:"apoptotic process") - pmid:29191965 + pubmed:14556719 - p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:SNCA) increases bp(GO:"apoptotic process") - pmid:27314526 + pubmed:30688256 - p(HGNC:CDK5) increases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:SNCA) increases act(a(MESH:Mitochondria)) - pmid:8282104 + pubmed:30688256 - p(HGNC:CDK5) directlyIncreases p(HBP:HBP00053, pmod(Ph)) + p(HGNC:SNCA) decreases path(MESH:"Oxidative Stress") - pmid:8282104 + pubmed:30688256 - p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 199)) + p(HGNC:SNCA) increases bp(GO:mitophagy) + + + + + + - pmid:17078951 + pubmed:21722302 - act(p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(Ph, Ser, 199)) + p(HGNC:SNCA) regulates bp(MESH:"Protein Stability") + + - pmid:8282104 + pubmed:26968346 - p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) + p(HGNC:SNCA) negativeCorrelation bp(GO:"regulation of glucosylceramidase activity") + + - pmid:8282104 + pubmed:27299292 - p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 235)) + p(HGNC:SNCA) increases p(HGNC:TFEB, loc(GO:cytoplasm)) + + - pmid:8282104 + pubmed:29758300 - p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + p(HGNC:SNCA) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:8282104 + pubmed:29758300 - p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + p(HGNC:SNCA) increases path(MESH:"Alzheimer Disease") - pmid:8282104 + pubmed:29758300 - p(HGNC:CDK5) association a(GO:microtubule) + p(HGNC:SNCA) increases path(MESH:"Parkinson Disease") - pmid:8282104 + pubmed:28803412 - p(HGNC:CDK5) association a(HBP:HBP00006) + p(HGNC:SNCA) association path(MESH:"Parkinson Disease") + + - pmid:8282104 + pubmed:29758300 - p(HGNC:CDK5) increases rxn(reactants(p(HGNC:MAPT)), products(p(HGNC:MAPT, pmod(Ph)))) + p(HGNC:SNCA) association bp(GO:"chaperone-mediated autophagy") + + + + - pmid:21882945 + pubmed:14556719 - p(HGNC:CDK5) increases act(p(HGNC:MARK2)) + p(HGNC:SNCA) association p(HGNC:SNCAIP) + + + + - pmid:21367866 + pubmed:22908190 - act(p(HGNC:CDK5)) positiveCorrelation p(HGNC:CDC37) + p(HGNC:SNCA) positiveCorrelation p(HGNC:SNCA, pmod(go:0016567 ! "protein ubiquitination")) - pmid:27796283 + pubmed:14556719 - p(HGNC:CDK5) increases p(HGNC:CAMKV, pmod(Ph, Thr, 345)) + p(HGNC:SNCA) regulates bp(GO:"dopamine secretion, neurotransmission") - pmid:17078951 + pubmed:14556719 - act(p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) + p(HGNC:SNCA) regulates bp(GO:"dopamine secretion") - pmid:17078951 + pubmed:30985105 - act(p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(Ph, Thr, 205)) + p(HGNC:SNCA) association bp(GO:"dopamine secretion") - pmid:17078951 + pubmed:14556719 - act(p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) + p(HGNC:SNCA) positiveCorrelation bp(CONSO:"Alpha-synuclein Oligomerization") + + + + - pmid:17078951 + pubmed:14556719 - act(p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(Ph, Ser, 422)) + act(p(HGNC:SNCA)) increases p(HGNC:SNCAIP, pmod(go:0016567 ! "protein ubiquitination")) - pmid:8702879 + pubmed:14556719 - act(p(HGNC:CDK5)) increases p(HGNC:SYN1, pmod(Ph, Ser, 551)) + act(p(HGNC:SNCA)) increases p(HGNC:TH, pmod(go:0016567 ! "protein ubiquitination")) - pmid:8702879 + pubmed:14556719 - act(p(HGNC:CDK5)) increases p(HGNC:SYN1, pmod(Ph, Ser, 553)) + act(p(HGNC:SNCA)) regulates bp(GO:"homeostatic process") - pmid:26118667 + pubmed:14556719 - p(HGNC:CDK5) increases complex(p(HGNC:CDK5), p(HGNC:CDK5R1)) + p(HGNC:SNCA) association a(MESH:"Inclusion Bodies") @@ -30528,46 +30571,36 @@

Statements

- pmid:30061532 + pubmed:22908190 - p(HGNC:CDK5R1) negativeCorrelation path(MESH:Schizophrenia) + p(HGNC:SNCA) increases complex(a(GO:"Lewy body"), p(HGNC:SNCA)) - pmid:30061532 + pubmed:25784053 - p(HGNC:CDK5R1) negativeCorrelation act(p(HGNC:CDK5)) + p(HGNC:SNCA) decreases bp(GO:autophagy) - pmid:26118667 + pubmed:25784053 - p(HGNC:CDK5R1) increases bp(GO:"neuron maturation") + p(HGNC:SNCA) decreases p(HGNC:RAB1A) - - - pmid:26118667 - - p(HGNC:CDK5R1) partOf complex(p(HGNC:CDK5), p(HGNC:CDK5R1)) - + - - - pmid:26118667 - - p(HGNC:CDK5R1) negativeCorrelation p(HBP:"CDK5R1 p25") - + @@ -30575,4599 +30608,4725 @@

Statements

- pmid:19126755 + pubmed:30985105 - path(HBP:neurotoxicity) association a(CHEBI:nicotine) + p(HGNC:SNCA) regulates a(GO:"synaptic vesicle") + + + + + + + + + + + + - pmid:19293145 + pubmed:30985105 - path(HBP:neurotoxicity) association a(HBP:"amyloid-beta oligomers") + p(HGNC:SNCA) increases a(CONSO:"alpha-synuclein fibrils") - pmid:19293145 + pubmed:29980653 - path(HBP:neurotoxicity) association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + tloc(p(HGNC:SNCA), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) increases a(CONSO:"alpha-synuclein fibrils") + + + + + + + + + + + + + + - pmid:22908190 + pubmed:21482353 - path(HBP:neurotoxicity) positiveCorrelation a(CHEBI:"amyloid-beta polypeptide 42") + a(MESH:"Dopaminergic Neurons") positiveCorrelation p(CONSO:"alpha-4 beta-2 nAChR") - pmid:24027553 + pubmed:19721446 - path(HBP:neurotoxicity) positiveCorrelation a(HBP:"Tau aggregates") + a(MESH:"Dopaminergic Neurons") association complex(p(HGNC:CHRNA4), p(HGNC:CHRNA6), p(HGNC:CHRNB2), p(HGNC:CHRNB3)) - pmid:26671985 + pubmed:19721446 - path(HBP:neurotoxicity) negativeCorrelation act(complex(GO:axon)) + a(MESH:"Dopaminergic Neurons") association complex(p(HGNC:CHRNA6), p(HGNC:CHRNB2), p(HGNC:CHRNB3)) - pmid:26671985 + pubmed:19721446 - path(HBP:neurotoxicity) positiveCorrelation a(HBP:"Tau oligomers") + a(MESH:"Dopaminergic Neurons") association complex(p(HGNC:CHRNA6), p(HGNC:CHRNB2)) - pmid:26671985 + pubmed:19721446 - path(HBP:neurotoxicity) association p(HGNC:MAPT, var("p.Asp421*")) + a(MESH:"Dopaminergic Neurons") association complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) - pmid:25652642 + pubmed:19721446 - bp(HBP:"APP processing") positiveCorrelation act(complex(GO:"NF-kappaB complex")) + a(MESH:"Dopaminergic Neurons") association complex(p(HGNC:CHRNA4), p(HGNC:CHRNA5), p(HGNC:CHRNB2)) - pmid:24653673 + pubmed:28901280 - bp(HBP:"APP processing") negativeCorrelation act(p(HGNC:GSK3B)) + a(MESH:"Dopaminergic Neurons") regulates a(MESH:Nicotine) - pmid:24653673 + pubmed:14556719 - bp(HBP:"APP processing") negativeCorrelation act(p(HGNC:CDK5)) + a(MESH:"Dopaminergic Neurons") negativeCorrelation p(HGNC:PRKN) - pmid:24653673 + pubmed:30663117 - bp(HBP:"APP processing") negativeCorrelation act(p(FPLX:ERK)) + bp(GO:"synaptic transmission, dopaminergic") association p(HGNC:SNCA) - pmid:30116051 + pubmed:22372633 - bp(HBP:"APP processing") association p(HGNC:LRRK2, var("?")) + bp(GO:"synaptic transmission, dopaminergic") positiveCorrelation p(HGNC:HDAC6) - pmid:24027553 + pubmed:22372633 - bp(HBP:"APP processing") association p(HGNC:HTRA1) + bp(GO:"synaptic transmission, dopaminergic") negativeCorrelation p(HGNC:SNCA, var("?")) - pmid:24027553 + pubmed:27013968 - bp(HBP:"APP processing") association path(MESH:"Alzheimer Disease") + bp(GO:"synaptic transmission, dopaminergic") negativeCorrelation p(HGNC:HTT, pmod(HBP:"CAG repeats")) - pmid:27094130 + pubmed:14556719 - bp(HBP:"APP processing") association p(HGNC:APP, pmod(Ph, Thr, 668)) + bp(GO:"synaptic transmission, dopaminergic") negativeCorrelation path(MESH:"Parkinson Disease") - pmid:27094130 + pubmed:30663117 - bp(HBP:"APP processing") increases a(CHEBI:"amyloid-beta") + p(HGNC:SNCA, var("?")) increases path(MESH:"Parkinson Disease") - - - pmid:28745240 + pubmed:18930136 - complex(p(HGNC:BACE1), p(HGNC:NFKB1), p(HGNC:RELA)) increases p(HGNC:BACE1) + p(HGNC:SNCA, var("?")) increases path(MESH:"Parkinson Disease") - - - - - - - - - pmid:28745240 + pubmed:30985105 - complex(p(HGNC:NFKB2), p(HGNC:RELA)) increases complex(p(HGNC:BACE1), p(HGNC:NFKB2), p(HGNC:RELA)) + p(HGNC:SNCA, var("?")) increases path(MESH:"Parkinson Disease") - - - pmid:28745240 + pubmed:29980653 - complex(p(HGNC:BACE1), p(HGNC:NFKB2), p(HGNC:RELA)) increases p(HGNC:BACE1) + p(HGNC:SNCA, var("?")) positiveCorrelation path(MESH:"Parkinson Disease") - pmid:28745240 + pubmed:22372633 - complex(p(HGNC:BACE1), p(HGNC:NFKB2), p(HGNC:RELA)) decreases p(HGNC:BACE1) + p(HGNC:SNCA, var("?")) increases p(HGNC:HDAC6, loc(GO:"perinuclear region of cytoplasm")) - - - - - - - - - pmid:28745240 + pubmed:22372633 - complex(p(HGNC:NFKB2), p(HGNC:REL)) increases complex(p(HGNC:BACE1), p(HGNC:NFKB2), p(HGNC:REL)) + p(HGNC:SNCA, var("?")) increases complex(a(HGNC:HDAC6), p(HGNC:SNCA), loc(GO:"perinuclear region of cytoplasm")) - - - - - - - pmid:28745240 + pubmed:22372633 - complex(GO:"gamma-secretase complex") regulates p(HBP:C99) + p(HGNC:SNCA, var("?")) negativeCorrelation bp(GO:"synaptic transmission, dopaminergic") - pmid:29758300 + pubmed:22372633 - complex(GO:"gamma-secretase complex") increases p(HGNC:APP, frag("?")) + p(HGNC:SNCA, var("?")) positiveCorrelation path(DOID:"retinal degeneration") - pmid:14556719 + pubmed:30061532 - complex(GO:"gamma-secretase complex") increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta polypeptide 40"), a(CHEBI:"amyloid-beta polypeptide 42"))) + p(HGNC:SNCA, var("?")) association path(MESH:"Psychotic Disorders") - pmid:14556719 + pubmed:21722302 - act(complex(GO:"gamma-secretase complex")) association p(HGNC:PSEN1, var("?")) + p(HGNC:SNCA, var("?")) increases path(DOID:"autosomal dominant Parkinson's disease 1") - pmid:14556719 + pubmed:26968346 - act(complex(GO:"gamma-secretase complex")) association p(HGNC:PSEN2, var("?")) + p(HGNC:SNCA, var("?")) negativeCorrelation bp(GO:"chaperone-mediated autophagy") - pmid:21214928 + pubmed:29758300 - p(HGNC:PSEN1) regulates p(HGNC:APP) + p(HGNC:SNCA, var("?")) association bp(GO:"chaperone-mediated autophagy") - - - pmid:19293145 + pubmed:26968346 - p(HGNC:PSEN1) causesNoChange path(HBP:Neurodegeneration) + p(HGNC:SNCA, var("?")) increases p(CONSO:"alpha-synuclein aggregates") - pmid:19293145 + pubmed:26968346 - p(HGNC:PSEN1) association path(MESH:"Alzheimer Disease") + p(HGNC:SNCA, var("?")) decreases p(HGNC:MEF2D) - pmid:29758300 + pubmed:27491084 - p(HGNC:PSEN1) association bp(GO:"calcium ion homeostasis") + p(HGNC:SNCA, var("?")) association path(HP:Neurodegeneration) - pmid:29758300 + pubmed:14556719 - p(HGNC:PSEN1) association bp(GO:"regulation of lysosomal lumen pH") + p(HGNC:SNCA, var("?")) association path(MESH:"Parkinsonian Disorders") - - - - - pmid:22908190 + pubmed:14556719 - p(HGNC:PSEN1) increases bp(GO:"pH reduction") + p(HGNC:SNCA, var("?")) increases bp(GO:"apoptotic process") - pmid:22908190 + pubmed:18930136 - p(HGNC:PSEN1) increases act(a(MESH:Cathepsins)) + p(HGNC:SNCA, var("?")) decreases tloc(p(HGNC:SNCA, var("?")), fromLoc(GO:cytoplasm), toLoc(GO:"lysosomal lumen")) - pmid:22908190 + pubmed:30116051 - p(HGNC:PSEN1) increases p(HGNC:ATP6V0A1, pmod(NGlyco)) + p(HGNC:SNCA, var("?")) decreases bp(GO:"autophagosome assembly") - pmid:24027553 + pubmed:30116051 - p(HGNC:PSEN1) increases bp(GO:"vacuolar acidification") + p(HGNC:SNCA, var("?")) decreases a(GO:"lysosomal membrane") - - - pmid:28745240 + pubmed:30116051 - act(complex(GO:"calcium- and calmodulin-dependent protein kinase complex")) increases act(complex(GO:"NF-kappaB complex")) + p(HGNC:SNCA, var("?")) decreases complex(GO:"proteasome complex") - pmid:28745240 + pubmed:30663117 - p(HGNC:SIRT1) decreases act(complex(GO:"NF-kappaB complex")) + a(GO:"Lewy body", loc(MESH:"Dopaminergic Neurons")) positiveCorrelation p(HGNC:SNCA) - pmid:28745240 + pubmed:21722302 - p(HGNC:SIRT1) decreases path(HBP:neurotoxicity) + a(GO:"Lewy body") increases p(HGNC:SNCA) - pmid:22020111 + pubmed:21722302 - p(HGNC:SIRT1) decreases p(HGNC:NFE2L2, pmod(Ac)) + a(GO:"Lewy body") biomarkerFor path(MESH:"Parkinson Disease") - pmid:30116051 + pubmed:21722302 - act(p(HGNC:SIRT1)) decreases act(p(FPLX:mTORC1)) + a(GO:"Lewy body") increases p(HGNC:SNCA, pmod(CONSO:misfolded)) - pmid:30116051 + pubmed:22908190 - act(p(HGNC:SIRT1)) increases act(p(HGNC:FOXO1)) + a(GO:"Lewy body") association a(MESH:Ubiquitin) - pmid:30116051 + pubmed:22908190 - act(p(HGNC:SIRT1)) increases act(p(HGNC:FOXO3)) + a(GO:"Lewy body") association a(MESH:Ubiquitin) - pmid:30116051 + pubmed:22908190 - act(p(HGNC:SIRT1)) increases act(p(HGNC:ATG5)) + a(GO:"Lewy body") positiveCorrelation path(MESH:Dementia) - pmid:30116051 + pubmed:22908190 - act(p(HGNC:SIRT1)) increases act(p(HGNC:ATG7)) + a(GO:"Lewy body") positiveCorrelation path(MESH:Dementia) + + - pmid:30116051 + pubmed:22908190 - act(p(HGNC:SIRT1)) increases act(p(HGNC:MAP1LC3A)) + a(GO:"Lewy body") association p(HGNC:MAPT) - pmid:30116051 + pubmed:18930136 - act(p(HGNC:SIRT1)) negativeCorrelation bp(GO:aging) + a(GO:"Lewy body") association p(HGNC:SQSTM1) - pmid:26631930 + pubmed:30663117 - p(HGNC:SIRT1) decreases p(HGNC:MAPT, pmod(Ac, Lys)) + g(HGNC:MIR7-1) regulates p(HGNC:SNCA) - pmid:20869593 + pubmed:30663117 - p(HGNC:SIRT1) decreases p(HGNC:MAPT, pmod(Ac)) + g(HGNC:MIR7-1) decreases p(HGNC:SNCA) - pmid:20869593 + pubmed:30663117 - act(p(HGNC:SIRT1)) negativeCorrelation p(HBP:"Tau epitope, AT8") + g(HGNC:MIR7-1) regulates p(HGNC:SNCA) + + - pmid:29540553 + pubmed:30663117 - p(HGNC:SIRT1) decreases p(HGNC:MAPT, pmod(Ac, Lys, 174)) + g(HGNC:MIR7-1) decreases path(MESH:"Parkinson Disease") - pmid:29540553 + pubmed:30663117 - p(HGNC:SIRT1) decreases path(HBP:"Pathological Tau Spreading") + complex(g(HGNC:MIR153-1), r(HGNC:SNCA)) decreases act(p(HGNC:SNCA)) + + + + + + + + - pmid:29540553 + pubmed:" 23273601" - act(p(HGNC:SIRT1)) decreases path(MESH:"Alzheimer Disease") + r(HGNC:SNCA) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:29540553 + pubmed:30663117 - p(HGNC:SIRT1) decreases path(MESH:"Alzheimer Disease") + complex(g(HGNC:MIR7-1), r(HGNC:SNCA)) decreases act(p(HGNC:SNCA)) - pmid:29540553 + pubmed:30663117 - act(p(HGNC:SIRT1)) decreases path(HP:Neurodegeneration) + complex(g(HGNC:MIR34B), r(HGNC:SNCA)) decreases p(HGNC:SNCA) + + - pmid:29540553 + pubmed:30663117 - p(HGNC:SIRT1) decreases path(HP:Neurodegeneration) + g(HGNC:MIR34B) increases p(HGNC:PARK7) - pmid:29540553 + pubmed:30663117 - p(HGNC:SIRT1) increases bp(GO:learning) + complex(g(HGNC:MIR34C), r(HGNC:SNCA)) decreases p(HGNC:SNCA) + + - pmid:29540553 + pubmed:30663117 - p(HGNC:SIRT1) increases bp(GO:memory) + g(HGNC:MIR34C) increases p(HGNC:PARK7) - pmid:29226865 + pubmed:30663117 - act(p(HGNC:SIRT1)) directlyDecreases p(HGNC:SRSF2, pmod(Ac, Lys, 52)) + g(HGNC:MIR132) regulates p(HGNC:SNCA) - pmid:28745240 + pubmed:30663117 - a(MESH:Calcineurin) increases act(complex(GO:"NF-kappaB complex")) + g(HGNC:MIR132) decreases p(HGNC:SNCA) - pmid:19293145 + pubmed:30663117 - a(MESH:Calcineurin) association act(a(CHEBI:nicotine)) + g(HGNC:MIR132) regulates p(HGNC:SNCA) - pmid:19293145 + pubmed:30663117 - a(MESH:Calcineurin) association bp(MESH:Neuroprotection) + g(HGNC:MIR132) association path(MESH:"Parkinson Disease") - pmid:28745240 + pubmed:30663117 - p(HGNC:CXCL8) increases bp(GO:"neuron death") + g(HGNC:MIR132) decreases path(MESH:"Parkinson Disease") - - - pmid:27288790 + pubmed:30663117 - p(FPLX:ERK) increases act(p(FPLX:NFkappaB)) + g(HGNC:MIR132) association p(HGNC:NR4A2) - pmid:19293145 + pubmed:30663117 - p(FPLX:ERK) association a(CHEBI:nicotine) + p(HGNC:NR4A2) association g(HGNC:MIR132) - pmid:24653673 + pubmed:30663117 - act(p(FPLX:ERK)) negativeCorrelation a(GO:"microtubule cytoskeleton") + g(NCBIGENE:406950) association path(MESH:"Parkinson Disease") - pmid:24653673 + pubmed:30663117 - act(p(FPLX:ERK)) negativeCorrelation a(GO:"neurofilament cytoskeleton") + g(NCBIGENE:406950) decreases a(MESH:"HSP70 Heat-Shock Proteins") - pmid:24653673 + pubmed:30663117 - act(p(FPLX:ERK)) negativeCorrelation p(HGNC:APP, pmod(Ph)) + g(NCBIGENE:406950) negativeCorrelation a(MESH:"HSP70 Heat-Shock Proteins") - pmid:24653673 + pubmed:30663117 - act(p(FPLX:ERK)) negativeCorrelation bp(HBP:"APP processing") + g(NCBIGENE:406950) increases a(CONSO:"alpha-synuclein aggregates") + + - pmid:24653673 + pubmed:30663117 - act(p(FPLX:ERK)) negativeCorrelation bp(GO:neurogenesis) + a(MESH:"HSP70 Heat-Shock Proteins") negativeCorrelation a(CONSO:"alpha-synuclein aggregates") - pmid:24653673 + pubmed:30663117 - act(p(FPLX:ERK)) positiveCorrelation bp(GO:"negative regulation of synaptic plasticity") + a(MESH:"HSP70 Heat-Shock Proteins") decreases a(CONSO:"alpha-synuclein aggregates") + + - pmid:24653673 + pubmed:30663117 - act(p(FPLX:ERK)) positiveCorrelation bp(GO:"apoptotic process") + a(MESH:"HSP70 Heat-Shock Proteins") negativeCorrelation g(NCBIGENE:406950) - pmid:12428809 + pubmed:25374103 - p(FPLX:ERK) increases p(HGNC:MAPT, pmod(Ph)) + a(MESH:"HSP70 Heat-Shock Proteins") increases deg(p(HGNC:MAPT, pmod(CONSO:misfolded))) + + + + + + + + - pmid:8282104 + pubmed:30663117 - p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(Ph)) + complex(a(MESH:"HSP70 Heat-Shock Proteins"), g(NCBIGENE:406950)) regulates act(a(MESH:"HSP70 Heat-Shock Proteins")) - pmid:8282104 + pubmed:30663117 - p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 199)) + g(HGNC:MIR133B) decreases path(MESH:"Parkinson Disease") - pmid:8282104 + pubmed:30663117 - p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) + g(HGNC:MIR133B) regulates p(HGNC:SNCA) - pmid:8282104 + pubmed:30663117 - p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 235)) + p(HGNC:LRRK2) association path(MESH:"Parkinson Disease") - pmid:8282104 + pubmed:30688256 - p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + p(HGNC:LRRK2) association path(MESH:"Parkinson Disease") - pmid:8282104 + pubmed:24113872 - p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + p(HGNC:LRRK2) positiveCorrelation path(MESH:"Parkinson Disease") + + + + - pmid:8282104 + pubmed:30663117 - p(FPLX:ERK) association a(GO:microtubule) + p(HGNC:LRRK2) decreases g(HGNC:MIRLET7A1) - pmid:8282104 + pubmed:30663117 - p(FPLX:ERK) association a(HBP:HBP00006) + p(HGNC:LRRK2) decreases act(g(HGNC:MIRLET7A1)) - pmid:8282104 + pubmed:30663117 - p(FPLX:ERK) increases rxn(reactants(p(HGNC:MAPT)), products(p(HGNC:MAPT, pmod(Ph)))) + p(HGNC:LRRK2) decreases g(HGNC:MIR184) - pmid:8282104 + pubmed:30663117 - p(FPLX:ERK) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:LRRK2) decreases act(g(HGNC:MIR184)) - pmid:27594586 + pubmed:24275654 - p(FPLX:ERK) regulates p(HGNC:MMP9) + p(HGNC:LRRK2) association p(HGNC:TUBB6) - pmid:24686445 + pubmed:24275654 - act(p(FPLX:ERK)) increases act(p(HGNC:KAT2B)) + p(HGNC:LRRK2) association p(HGNC:TUBB4A) - pmid:25001178 + pubmed:30515821 - p(FPLX:ERK) increases act(p(HGNC:CDK5), ma(kin)) + p(HGNC:LRRK2) regulates a(MESH:"Transport Vesicles") - pmid:29179999 + pubmed:30515821 - path(HP:Neurodegeneration) association act(p(FPLX:NFkappaB)) + p(HGNC:LRRK2) regulates bp(GO:autophagy) - pmid:27491084 + pubmed:30515821 - path(HP:Neurodegeneration) association p(HGNC:ATXN3, var("?")) + p(HGNC:LRRK2) regulates path(NCIT:C17741) - pmid:27491084 + pubmed:30515821 - path(HP:Neurodegeneration) association p(HGNC:AR, var("?")) + p(HGNC:LRRK2) regulates path(MESH:"Neurotoxicity Syndromes") - pmid:27491084 + pubmed:30515821 - path(HP:Neurodegeneration) association p(HGNC:SNCA, var("?")) + p(HGNC:LRRK2) regulates path(MESH:"Mitochondrial Dynamics") - pmid:23528736 + pubmed:30515821 - path(HP:Neurodegeneration) association bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + p(HGNC:LRRK2) increases bp(GO:"mitochondrial fission") + + + + + + - pmid:29221819 + pubmed:30688256 - path(HP:Neurodegeneration) positiveCorrelation p(MGI:Dyrk1a) + p(HGNC:LRRK2) decreases bp(GO:"apoptotic process") - pmid:24563850 + pubmed:30688256 - act(p(FPLX:"NADPH_oxidase")) increases a(CHEBI:radical) + p(HGNC:LRRK2) increases act(a(MESH:Mitochondria)) - pmid:24563850 + pubmed:30688256 - act(p(FPLX:"NADPH_oxidase")) increases a(CHEBI:"reactive oxygen species") + p(HGNC:LRRK2) decreases path(MESH:"Oxidative Stress") - pmid:24563850 + pubmed:30688256 - act(p(FPLX:"NADPH_oxidase")) increases a(CHEBI:"reactive nitrogen species") + p(HGNC:LRRK2) increases bp(GO:mitophagy) + + - pmid:27288790 + pubmed:24113872 - p(HGNC:PTGS2) positiveCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNC:LRRK2), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 149)) - pmid:27288790 + pubmed:24113872 - p(HGNC:PTGS2) association a(HBP:"amyloid-beta aggregates") + act(p(HGNC:LRRK2), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 153)) - pmid:27288790 + pubmed:24113872 - p(HGNC:PTGS2) increases path(MESH:Inflammation) + act(p(HGNC:LRRK2), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) - pmid:19126755 + pubmed:24113872 - act(p(HGNC:PTGS2)) increases a(CHEBI:"prostaglandin H2") + act(p(HGNC:LRRK2), ma(go:0016301 ! "kinase activity")) directlyIncreases p(CONSO:"Tau aggregates") - pmid:19126755 + pubmed:24113872 - p(HGNC:PTGS2, loc(MESH:Neurons)) regulates path(MESH:"Neuronal Plasticity") + act(p(HGNC:LRRK2), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) - pmid:19126755 + pubmed:24113872 - p(HGNC:PTGS2, loc(MESH:Neurons)) regulates bp(GO:"cell death") + act(p(HGNC:LRRK2), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) - pmid:19126755 + pubmed:30663117 - p(HGNC:PTGS2) association p(HGNC:CHRNA4) + p(HGNC:LRRK2, var("?")) increases bp(GO:"neuron death") - pmid:27314526 + pubmed:21722302 - sec(a(MESH:Interleukins)) association path(MESH:Dementia) + p(HGNC:LRRK2, var("?")) increases path(DOID:"autosomal dominant Parkinson's disease 1") - pmid:27314526 + pubmed:21722302 - sec(a(MESH:Interleukins)) association bp(HBP:neuroinflammation) + p(HGNC:LRRK2, var("?")) decreases bp(GO:"protein catabolic process") - pmid:29179999 + pubmed:21722302 - a(CHEBI:curcumin) decreases bp(GO:"inflammatory response") + p(HGNC:LRRK2, var("?")) increases a(CONSO:"alpha-synuclein aggregates") - pmid:29179999 + pubmed:21722302 - a(CHEBI:curcumin) decreases p(HGNC:PTGS2) + p(HGNC:LRRK2, var("?")) increases a(MESH:"Ubiquitinated Proteins") - pmid:29179999 + pubmed:21722302 - a(CHEBI:curcumin) decreases p(HGNC:LOX) + p(HGNC:LRRK2, var("?")) decreases bp(GO:"lysosomal protein catabolic process") - pmid:29179999 + pubmed:21722302 - a(CHEBI:curcumin) decreases p(HGNC:NOS2) + p(HGNC:LRRK2, var("?")) decreases bp(GO:"regulation of protein oxidation") - pmid:29179999 + pubmed:21722302 - a(CHEBI:curcumin) decreases p(HGNC:TNF) + p(HGNC:LRRK2, var("?")) increases bp(GO:"inflammatory response") - pmid:29179999 + pubmed:21722302 - a(CHEBI:curcumin) decreases p(HGNC:IL1A) + p(HGNC:LRRK2, var("?")) increases bp(MESH:Apoptosis) - pmid:29179999 + pubmed:30116051 - a(CHEBI:curcumin) decreases p(HGNC:IL2) + p(HGNC:LRRK2, var("?")) association path(MESH:"Parkinson Disease") - pmid:29179999 + pubmed:30116051 - a(CHEBI:curcumin) decreases p(HGNC:IL6) + p(HGNC:LRRK2, var("?")) decreases bp(GO:autophagy) - pmid:29179999 + pubmed:30116051 - a(CHEBI:curcumin) decreases p(HGNC:CXCL8) + p(HGNC:LRRK2, var("?")) decreases act(p(HGNC:BECN1)) - pmid:29179999 + pubmed:30116051 - a(CHEBI:curcumin) decreases p(HGNC:IL12B) + p(HGNC:LRRK2, var("?")) association bp(CONSO:"APP processing") - pmid:29179999 + pubmed:30116051 - a(CHEBI:curcumin) decreases act(p(FPLX:NFkappaB)) + p(HGNC:LRRK2, var("?")) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:29179999 + pubmed:30663117 - a(CHEBI:curcumin) decreases p(HGNC:NFKBIA, pmod(Ph)) + p(HGNC:LRRK2, var("p.Gly2019Ser")) increases path(MESH:"Parkinson Disease") - pmid:29179999 + pubmed:30515821 - a(CHEBI:curcumin) decreases deg(p(HGNC:NFKBIA)) + p(HGNC:LRRK2, var("p.Gly2019Ser")) increases act(p(HGNC:LRRK2), ma(GO:"kinase activity")) + + - pmid:29179999 + pubmed:30515821 - a(CHEBI:curcumin) decreases tloc(p(HGNC:RELA), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) + p(HGNC:LRRK2, var("p.Gly2019Ser")) increases path(DOID:"Parkinson's disease") - pmid:28803412 + pubmed:30515821 - a(CHEBI:curcumin) decreases a(HBP:HBP00092) + p(HGNC:LRRK2, var("p.Gly2019Ser")) increases bp(GO:"mitochondrial fission") - pmid:28803412 + pubmed:28803412 - a(CHEBI:curcumin) decreases a(HBP:HBP00016) + p(HGNC:LRRK2, var("p.Gly2019Ser")) increases path(MESH:"Neurodegenerative Diseases") - pmid:28803412 + pubmed:30663117 - a(CHEBI:curcumin) decreases a(HBP:HBP00018) + g(HGNC:MIR205) regulates p(HGNC:LRRK2) - pmid:30116051 + pubmed:30663117 - a(CHEBI:curcumin) increases bp(GO:macroautophagy) + g(HGNC:MIR205) regulates p(HGNC:LRRK2) - pmid:30116051 + pubmed:30663117 - a(CHEBI:curcumin) decreases act(p(FPLX:mTORC1)) + g(HGNC:MIRLET7A1) decreases p(HGNC:E2F1) - pmid:30116051 + pubmed:30663117 - a(CHEBI:curcumin) increases deg(p(HGNC:SNCA, var("p.Ala53Thr"))) + g(HGNC:MIRLET7A1) decreases act(p(HGNC:E2F1)) - pmid:30116051 + pubmed:30663117 - a(CHEBI:curcumin) decreases a(HBP:"alpha-synuclein aggregates") + g(HGNC:MIRLET7A1) decreases p(HGNC:TFDP1) - pmid:30116051 + pubmed:30663117 - a(CHEBI:curcumin) decreases a(HBP:"amyloid-beta oligomers") + g(HGNC:MIRLET7A1) decreases act(p(HGNC:TFDP1)) - pmid:30116051 + pubmed:30663117 - a(CHEBI:curcumin) decreases a(HBP:"Tau oligomers") + g(HGNC:MIR184) decreases p(HGNC:E2F1) - pmid:27288790 + pubmed:30663117 - p(HGNC:NOS2) increases path(MESH:Inflammation) + g(HGNC:MIR184) decreases act(p(HGNC:E2F1)) - pmid:23702978 + pubmed:30663117 - act(p(HGNC:NOS2)) increases a(CHEBI:"nitric oxide") + g(HGNC:MIR184) decreases p(HGNC:TFDP1) - pmid:27314526 + pubmed:30663117 - act(p(HGNC:NOS2)) increases a(CHEBI:"nitric oxide") + g(HGNC:MIR184) decreases act(p(HGNC:TFDP1)) - pmid:27288790 + pubmed:30663117 - p(HGNC:NFKBIA, pmod(Ph)) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) + p(HGNC:PARK7) decreases a(CONSO:"alpha-synuclein aggregates") - pmid:29179999 + pubmed:30663117 - a(CHEBI:resveratrol) decreases p(HGNC:TNF) + p(HGNC:PARK7) decreases bp(GO:"apoptotic process") - pmid:29179999 + pubmed:30688256 - a(CHEBI:resveratrol) decreases p(HGNC:PTGS2) + p(HGNC:PARK7) decreases bp(GO:"apoptotic process") - pmid:29179999 + pubmed:30663117 - a(CHEBI:resveratrol) decreases p(HGNC:PTGS2) + p(HGNC:PARK7) decreases bp(GO:"neuron death") - pmid:29179999 + pubmed:30688256 - a(CHEBI:resveratrol) decreases a(MESH:Interleukins) + p(HGNC:PARK7) increases act(a(MESH:Mitochondria)) - pmid:29179999 + pubmed:30688256 - a(CHEBI:resveratrol) decreases p(FPLX:"IKK_complex", pmod(Ph)) + p(HGNC:PARK7) decreases path(MESH:"Oxidative Stress") - pmid:29179999 + pubmed:30688256 - a(CHEBI:resveratrol) decreases p(HGNC:NFKBIA, pmod(Ph)) + p(HGNC:PARK7) increases bp(GO:mitophagy) + + - pmid:29179999 + pubmed:21722302 - a(CHEBI:resveratrol) decreases act(p(FPLX:NFkappaB)) + p(HGNC:PARK7) increases bp(GO:"detection of redox state") + + - pmid:29179999 + pubmed:21722302 - a(CHEBI:resveratrol) decreases p(HGNC:STAT1, pmod(Ph)) + p(HGNC:PARK7) regulates bp(MESH:"Protein Stability") - pmid:29179999 + pubmed:30562574 - a(CHEBI:resveratrol) decreases p(HGNC:STAT3, pmod(Ph)) + p(HGNC:PARK7) association path(MESH:"Parkinson Disease") - pmid:29179999 + pubmed:30562574 - a(CHEBI:resveratrol) decreases a(CHEBI:"nitric oxide") + p(HGNC:PARK7) isA a(MESH:Antioxidants) - pmid:29179999 + pubmed:30562574 - a(CHEBI:resveratrol) decreases p(HGNC:NOS2) + p(HGNC:PARK7) increases path(MESH:"Neuronal Outgrowth") - pmid:29179999 + pubmed:30562574 - a(CHEBI:resveratrol) decreases a(CHEBI:"prostaglandin E2") + p(HGNC:PARK7) increases bp(GO:"neuron projection development") - pmid:22020111 + pubmed:30562574 - a(CHEBI:resveratrol) increases act(p(HGNC:SIRT1)) + p(HGNC:PARK7) association path(DOID:"Parkinson's disease") - pmid:30116051 + pubmed:30562574 - a(CHEBI:resveratrol) increases act(p(HGNC:SIRT1)) + p(HGNC:PARK7) association path(DOID:"Parkinson's disease") - pmid:22020111 + pubmed:30562574 - a(CHEBI:resveratrol) decreases act(p(HGNC:NFE2L2)) + p(HGNC:PARK7) isA a(CHEBI:antioxidant) - pmid:30116051 + pubmed:30562574 - a(CHEBI:resveratrol) increases act(p(HGNC:CAMKK2)) + p(HGNC:PARK7) association path(MESH:"Neurodegenerative Diseases") - pmid:30116051 + pubmed:30562574 - a(CHEBI:resveratrol) decreases a(CHEBI:"amyloid-beta") + p(HGNC:PARK7) association bp(GO:"mitochondrial depolarization") - pmid:30116051 + pubmed:30562574 - a(CHEBI:resveratrol) decreases p(HGNC:HTT) + p(HGNC:PARK7) increases bp(GO:"cellular response to oxidative stress") - - - pmid:30116051 - - a(CHEBI:resveratrol) increases act(p(FPLX:AMPK)) - + - - - pmid:30116051 - - a(CHEBI:resveratrol) decreases act(a(MESH:"amyloid beta-protein (25-35)")) - + - pmid:30116051 + pubmed:30663117 - a(CHEBI:resveratrol) increases p(FPLX:ATG4) + path(MESH:Chorea) association path(MESH:"Huntington Disease") - pmid:30116051 + pubmed:29687724 - a(CHEBI:resveratrol) increases bp(GO:"autophagosome assembly") + path(MESH:Chorea) association path(MESH:"Huntington Disease") - pmid:30116051 + pubmed:29687724 - a(CHEBI:resveratrol) decreases p(HGNC:AGER) + path(MESH:Chorea) association path(MESH:"Neural Pathways") - pmid:30116051 + pubmed:29687724 - a(CHEBI:resveratrol) decreases p(HGNC:MMP9) + path(MESH:Chorea) association a(CHEBI:dopamine) - pmid:30116051 + pubmed:30988501 - a(CHEBI:resveratrol) decreases a(CHEBI:"amyloid-beta polypeptide 42") + path(MESH:Chorea) increases path(MESH:"Movement Disorders") - pmid:29062069 + pubmed:30988501 - a(CHEBI:resveratrol) decreases p(HGNC:MID1) + path(MESH:Chorea) association path(DOID:"rheumatic fever") - pmid:29062069 + pubmed:30663117 - a(CHEBI:resveratrol) increases act(p(HGNC:PPP2CA)) + path(MESH:Dementia) association path(MESH:"Huntington Disease") - pmid:29062069 + pubmed:30012004 - a(CHEBI:resveratrol) decreases p(HGNC:MAPT, pmod(Ph)) + path(MESH:Dementia) positiveCorrelation path(MESH:"Huntington Disease") - - - pmid:27288790 + pubmed:22236693 - act(p(FPLX:"IKK_complex")) increases p(FPLX:IKB, pmod(Ph)) + path(MESH:Dementia) association g(HGNC:NGFR) - - - pmid:23702978 + pubmed:19126755 - act(p(HGNC:STAT1)) increases act(p(HGNC:SCAF11)) + path(MESH:Dementia) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:23178521 + pubmed:19293145 - p(HGNC:STAT3, pmod(Ph)) association a(CHEBI:nicotine) + path(MESH:Dementia) association path(MESH:"Alzheimer Disease") - pmid:29179999 + pubmed:24511233 - a(CHEBI:pterostilbene) regulates p(HGNC:PPARA) + path(MESH:Dementia) association path(MESH:"Alzheimer Disease") - pmid:29179999 + pubmed:25514383 - a(CHEBI:pterostilbene) regulates p(FPLX:NFkappaB) + path(MESH:Dementia) association path(MESH:"Alzheimer Disease") - pmid:29179999 + pubmed:26813123 - a(CHEBI:pterostilbene) regulates p(FPLX:JNK, pmod(Ph)) + path(MESH:Dementia) association bp(GO:"synaptic transmission, cholinergic") - pmid:21718217 + pubmed:25514383 - p(HGNC:PPARA) regulates bp(GO:"lipid oxidation") + path(MESH:Dementia) association bp(GO:aging) - pmid:21718217 + pubmed:18986241 - p(HGNC:PPARA) regulates bp(MESH:"Lipid Peroxidation") + path(MESH:Dementia) association path(CONSO:aMCI) - pmid:18494933 + pubmed:18986241 - p(FPLX:JNK, pmod(Ph)) increases act(p(HGNC:MAPK8)) + path(MESH:Dementia) association path(MESH:"Cholinergic Neurons") - - - pmid:18494933 + pubmed:18986241 - p(FPLX:JNK) positiveCorrelation act(p(HGNC:AGER)) + path(MESH:Dementia) decreases p(HGNC:ACHE) - pmid:18494933 + pubmed:29758300 - p(FPLX:JNK) increases p(HGNC:DKK1) + path(MESH:Dementia) association path(MESH:Tauopathies) - pmid:18494933 + pubmed:22908190 - act(p(FPLX:JNK)) increases p(HGNC:DKK1) + path(MESH:Dementia) positiveCorrelation a(GO:"Lewy body") - pmid:27068745 + pubmed:22908190 - act(p(FPLX:JNK)) positiveCorrelation p(ECCODE:"1.6.3.1") + path(MESH:Dementia) positiveCorrelation a(GO:"Lewy body") - pmid:27068745 + pubmed:22908190 - act(p(FPLX:JNK)) association p(HGNC:CASP3) + path(MESH:Dementia) positiveCorrelation p(HGNC:SNCA, pmod(go:0016567 ! "protein ubiquitination")) - - - pmid:29179999 + pubmed:26091809 - a(PUBCHEM:44584733) decreases p(HGNC:PTGS2) + path(MESH:Dementia) increases path(MESH:Mortality) - pmid:29179999 + pubmed:27314526 - a(PUBCHEM:44584733) decreases complex(a(MESH:DNA), p(FPLX:NFkappaB)) + path(MESH:Dementia) association tloc(a(MESH:Interleukins), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:29179999 + pubmed:27314526 - a(PUBCHEM:44584733) decreases bp(GO:"inflammatory response") + path(MESH:Dementia) positiveCorrelation p(HGNC:IL1B) - - - - - pmid:29179999 + pubmed:27314526 - a(CHEBI:"methyl 3,5-di-O-caffeoyl quinate") decreases bp(GO:"NIK/NF-kappaB signaling") + path(MESH:Dementia) positiveCorrelation p(HGNC:IL18) - pmid:29179999 + pubmed:30663117 - a(CHEBI:"methyl 3,5-di-O-caffeoyl quinate") increases p(HGNC:NFKBIA, pmod(Ph)) + path(MESH:"Deglutition Disorders") association path(MESH:"Huntington Disease") - pmid:29179999 + pubmed:30663117 - a(CHEBI:"methyl 3,5-di-O-caffeoyl quinate") increases p(HGNC:MAPK14, pmod(Ph)) + path(MESH:Aphasia) association path(MESH:"Huntington Disease") - pmid:29179999 + pubmed:30663117 - a(CHEBI:"methyl 3,5-di-O-caffeoyl quinate") increases p(FPLX:ERK, pmod(Ph)) + path(MESH:Seizures) association path(MESH:"Huntington Disease") - - - pmid:27288790 + pubmed:30515821 - p(HGNC:MAPK14) increases act(p(FPLX:NFkappaB)) + path(MESH:Seizures) increases path(MESH:"Wounds and Injuries") - pmid:27288790 + pubmed:21787755 - act(p(HGNC:MAPK14)) increases p(HGNC:NFKBIA, pmod(Ph)) + path(MESH:Seizures) association p(CONSO:"alpha-7-containing nAChR") - pmid:27288790 + pubmed:30663117 - act(p(HGNC:MAPK14)) increases p(HGNC:NFKBIA, pmod(Ph)) + p(HGNC:HTT, var("?")) increases path(MESH:"Huntington Disease") - pmid:27288790 + pubmed:14556719 - act(p(HGNC:MAPK14)) increases tloc(p(HGNC:RELA), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) + p(HGNC:HTT, var("?")) increases path(MESH:"Huntington Disease") + + - pmid:30640040 + pubmed:30515821 - act(p(HGNC:MAPK14)) increases a(HBP:"Tau aggregates") + p(HGNC:HTT, var("?")) increases a(CHEBI:"nitric oxide") - pmid:23531502 + pubmed:14556719 - act(p(HGNC:MAPK14)) association a(HBP:"Tau aggregates") + p(HGNC:HTT, var("?")) increases a(CONSO:"huntingtin aggregates") - pmid:30640040 + pubmed:14556719 - p(HGNC:MAPK14) association a(PUBCHEM:11570805) + p(HGNC:HTT, var("?")) decreases act(complex(GO:"proteasome complex")) - pmid:30640040 + pubmed:14556719 - p(HGNC:MAPK14) association a(PUBCHEM:156422) + p(HGNC:HTT, var("?")) increases bp(GO:"cell cycle arrest") - pmid:30640040 + pubmed:14556719 - p(HGNC:MAPK14) association a(PUBCHEM:10341154) + p(HGNC:HTT, var("?")) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:11943212 + pubmed:14556719 - p(HGNC:MAPK14) increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) + p(HGNC:HTT, var("?")) decreases act(p(CONSO:"20 S Proteasome")) - pmid:27594586 + pubmed:14556719 - p(FPLX:ERK, pmod(Ph)) positiveCorrelation act(p(HGNC:MMP9)) + p(HGNC:HTT, var("?")) decreases deg(p(HGNC:TP53)) - pmid:27594586 + pubmed:14556719 - p(FPLX:ERK, pmod(Ph)) positiveCorrelation sec(p(HGNC:MMP9)) + p(HGNC:HTT, var("?")) decreases bp(MESH:"Membrane Potential, Mitochondrial") - pmid:29121589 + pubmed:14556719 - p(FPLX:ERK, pmod(Ph)) increases act(p(FPLX:ERK)) + p(HGNC:HTT, var("?")) increases tloc(a(CHEBI:"cytochrome c"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:29179999 + pubmed:14556719 - a(CHEBI:Salidroside) increases bp(GO:cognition) + p(HGNC:HTT, var("?")) increases act(p(FPLX:Caspase)) - pmid:29179999 + pubmed:14556719 - a(CHEBI:Salidroside) regulates p(HGNC:TXN) + p(HGNC:HTT, var("?")) increases bp(GO:"apoptotic process") - pmid:29179999 + pubmed:25784053 - a(CHEBI:Salidroside) regulates p(HGNC:TXNIP) + p(HGNC:HTT, var("?")) increases p(FPLX:HSPA) - pmid:29179999 + pubmed:30116051 - a(CHEBI:Salidroside) regulates p(HGNC:RELA) + p(HGNC:HTT, var("?")) decreases bp(GO:autophagy) - pmid:29179999 + pubmed:30116051 - a(CHEBI:Salidroside) regulates p(HGNC:NFKBIA) + p(HGNC:HTT, var("?")) decreases bp(GO:"cargo loading into vesicle") - pmid:29179999 + pubmed:30116051 - a(CHEBI:Salidroside) regulates p(HGNC:CHUK) + p(HGNC:HTT, var("?")) decreases bp(GO:"autophagosome assembly") - pmid:29179999 + pubmed:27181519 - a(CHEBI:Salidroside) regulates p(HGNC:IKBKB) + p(HGNC:HTT, var("?")) increases p(HGNC:HTT, pmod(CONSO:"protein aggregation")) - - - pmid:29179999 - - a(PUBCHEM:155160) increases bp(GO:memory) - + + + - pmid:29179999 + pubmed:23516100 - a(PUBCHEM:155160) decreases a(HBP:"amyloid-beta aggregates") + p(HGNC:HTT) increases p(HGNC:HTT, frag("?")) + + - pmid:29179999 + pubmed:23516100 - a(PUBCHEM:155160) decreases path(MESH:"Oxidative Stress") + p(HGNC:HTT) increases a(CHEBI:"calcium(2+)", loc(GO:intracellular)) - pmid:29179999 + pubmed:23516100 - a(PUBCHEM:155160) decreases path(MESH:Inflammation) + p(HGNC:HTT) increases act(p(HGNCGENEFAMILY:Calpains)) - - - pmid:29179999 - - a(PUBCHEM:155160) decreases a(CHEBI:"amyloid-beta polypeptide 42") - + - - - pmid:29179999 - - a(PUBCHEM:155160) decreases act(p(FPLX:"Gamma_secretase")) - + - pmid:29179999 + pubmed:23516100 - a(PUBCHEM:155160) decreases act(p(HGNC:BACE1)) + p(HGNC:HTT) decreases act(p(HGNC:CASP3)) - pmid:29179999 + pubmed:30688256 - a(PUBCHEM:155160) decreases act(p(FPLX:NFkappaB)) + p(HGNC:HTT) association bp(GO:mitophagy) - pmid:27288790 + pubmed:30362565 - a(HBP:"amyloid-beta aggregates") increases act(p(FPLX:"IKK_complex")) + act(p(HGNC:HTT)) increases p(HGNC:BDNF) - pmid:27288790 + pubmed:30985105 - a(HBP:"amyloid-beta aggregates") association p(HGNC:PTGS2) + p(HGNC:HTT) association p(HGNC:BDNF) - pmid:30444369 + pubmed:30362565 - a(HBP:"amyloid-beta aggregates") increases path(HBP:"mitochondrial dysfunction") + act(p(HGNC:HTT)) increases path(MESH:"Transport Vesicles") - pmid:30444369 + pubmed:30362565 - a(HBP:"amyloid-beta aggregates") decreases act(p(FPLX:COX)) + p(HGNC:HTT) regulates path(MESH:Autophagy) - - - pmid:19293145 - - a(HBP:"amyloid-beta aggregates") association path(MESH:"Alzheimer Disease") - + - pmid:24590577 + pubmed:30027901 - a(HBP:"amyloid-beta aggregates") increases path(MESH:"Alzheimer Disease") + act(p(HGNC:HTT)) association bp(GO:"intracellular transport") - pmid:25514383 + pubmed:30027901 - a(HBP:"amyloid-beta aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:HTT) association bp(GO:"intracellular transport") - pmid:22817713 + pubmed:30027901 - a(HBP:"amyloid-beta aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNC:HTT)) association bp(GO:endocytosis) - pmid:24511233 + pubmed:30027901 - a(HBP:"amyloid-beta aggregates") association path(MESH:"Plaque, Amyloid") + act(p(HGNC:HTT)) increases bp(GO:"chemical synaptic transmission") - pmid:24590577 + pubmed:30027901 - a(HBP:"amyloid-beta aggregates") increases path(MESH:"Plaque, Amyloid") + act(p(HGNC:HTT)) increases bp(GO:"mRNA transcription") - pmid:26195256 + pubmed:23393546 - a(HBP:"amyloid-beta aggregates") association path(MESH:"Plaque, Amyloid") + p(HGNC:HTT) increases bp(GO:"mRNA transcription") - pmid:17009926 + pubmed:30027901 - a(HBP:"amyloid-beta aggregates") association p(HGNC:CHRNA7) + act(p(HGNC:HTT)) association bp(GO:autophagy) - pmid:21722302 + pubmed:30027901 - a(HBP:"amyloid-beta aggregates") association path(HBP:Neurodegeneration) + p(HGNC:HTT) association bp(GO:autophagy) - - - pmid:27491084 - - a(HBP:"amyloid-beta aggregates") association p(HGNC:HSPB1) - + + + - pmid:27491084 + pubmed:30027901 - a(HBP:"amyloid-beta aggregates") association p(HGNC:CRYAB) + p(HGNC:HTT) increases p(HGNC:HTT, pmod(go:0006468 ! "protein phosphorylation")) + + - pmid:27491084 + pubmed:30027901 - a(HBP:"amyloid-beta aggregates") association p(HGNC:HSPB6) + p(HGNC:HTT) increases p(HGNC:HTT, pmod(go:0006473 ! "protein acetylation")) + + - pmid:27491084 + pubmed:30027901 - a(HBP:"amyloid-beta aggregates") association p(HGNC:HSPB8) + p(HGNC:HTT) increases p(HGNC:HTT, pmod(go:0018345 ! "protein palmitoylation")) + + - pmid:28877763 + pubmed:30027901 - a(HBP:"amyloid-beta aggregates") positiveCorrelation p(MGI:Syk, pmod(Ph)) + p(HGNC:HTT) increases p(HGNC:HTT, pmod(go:0016567 ! "protein ubiquitination")) + + - pmid:28877763 + pubmed:30027901 - a(HBP:"amyloid-beta aggregates") positiveCorrelation act(p(MGI:Syk)) + p(HGNC:HTT) increases p(HGNC:HTT, pmod(go:0016925 ! "protein sumoylation")) - - - pmid:28877763 - - a(HBP:"amyloid-beta aggregates") positiveCorrelation act(p(HGNC:SYK)) - + + + + + - pmid:26195256 + pubmed:30027901 - a(HBP:"amyloid-beta aggregates") association path(MESH:"Cerebral Amyloid Angiopathy") + p(HGNC:HTT) increases tloc(a(MESH:Autophagosomes), fromLoc(GO:"distal axon"), toLoc(GO:"cell body")) - pmid:26195256 + pubmed:30027901 - a(HBP:"amyloid-beta aggregates", loc(GO:"extracellular region")) negativeCorrelation a(CHEBI:"amyloid-beta polypeptide 42", loc(MESH:"Cerebrospinal Fluid")) + p(HGNC:HTT) association a(MESH:Autophagosomes) - pmid:26195256 + pubmed:30027901 - a(HBP:"amyloid-beta aggregates") decreases a(MESH:"Cerebrospinal Fluid") + p(HGNC:HTT) regulates deg(p(HGNC:HTT)) - pmid:29179999 + pubmed:30027901 - a(CHEBI:"amyloid-beta polypeptide 42") increases bp(GO:"neuron death") + p(HGNC:HTT) association a(MESH:Lysosomes) - pmid:27288790 + pubmed:30027901 - a(CHEBI:"amyloid-beta polypeptide 42") increases p(FPLX:IKB, pmod(Ph, Ser, 32)) + p(HGNC:HTT) association a(MESH:"Synaptic Vesicles") - pmid:27288790 + pubmed:30027901 - a(CHEBI:"amyloid-beta polypeptide 42") increases p(FPLX:IKB, pmod(Ph, Ser, 36)) + p(HGNC:HTT) association composite(a(MESH:"Cytoplasmic Vesicles"), p(HGNC:BDNF)) - pmid:27288790 + pubmed:30027901 - a(CHEBI:"amyloid-beta polypeptide 42") increases p(FPLX:NFkappaB, pmod(Ph, Ser, 536)) + p(HGNC:HTT) association composite(a(CHEBI:"gamma-aminobutyric acid"), a(MESH:"Cytoplasmic Vesicles")) - pmid:27288790 + pubmed:30027901 - a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:BACE1) + p(HGNC:HTT) association bp(GO:"clathrin-dependent endocytosis") - pmid:25652642 + pubmed:30027901 - a(CHEBI:"amyloid-beta polypeptide 42") regulates p(HGNC:BACE1) + p(HGNC:HTT) increases p(HGNC:RAB11A) - pmid:27288790 + pubmed:30027901 - a(CHEBI:"amyloid-beta polypeptide 42") increases r(HGNC:"BACE1-AS") + p(HGNC:HTT) increases bp(GO:"cytosolic ciliogenesis") + + + + + + + + + + + + - pmid:25652642 + pubmed:23393546 - a(CHEBI:"amyloid-beta polypeptide 42") regulates p(HGNC:APP) + p(HGNC:HTT) increases p(MESH:"Transport Vesicles") - pmid:25652642 + pubmed:23393546 - a(CHEBI:"amyloid-beta polypeptide 42") increases act(complex(GO:"NF-kappaB complex")) + p(HGNC:HTT) increases path(MESH:"Energy Metabolism") - pmid:25652642 + pubmed:23393546 - a(CHEBI:"amyloid-beta polypeptide 42") increases act(complex(GO:"NF-kappaB complex")) + p(HGNC:HTT) increases bp(GO:"embryo development") + + + + - pmid:25652642 + pubmed:19933700 - a(CHEBI:"amyloid-beta polypeptide 42") increases complex(p(HGNC:NFKB1), p(HGNC:RELA)) + p(HGNC:HTT) decreases r(HGNC:HOXB1) - pmid:25652642 + pubmed:19933700 - a(CHEBI:"amyloid-beta polypeptide 42") regulates bp(GO:"cell death") + p(HGNC:HTT) decreases r(HGNC:HOXB2) - pmid:25652642 + pubmed:19933700 - a(CHEBI:"amyloid-beta polypeptide 42") positiveCorrelation act(a(MESH:Microglia)) + p(HGNC:HTT) decreases r(HGNC:HOXB9) - pmid:25652642 + pubmed:19933700 - a(CHEBI:"amyloid-beta polypeptide 42") increases bp(GO:"positive regulation of advanced glycation end-product receptor activity") + p(HGNC:HTT) increases path(MESH:"Cell Differentiation") - pmid:25652642 + pubmed:19933700 - a(CHEBI:"amyloid-beta polypeptide 42") increases bp(GO:"peroxisome proliferator activated receptor signaling pathway") + p(HGNC:HTT) association p(CONSO:"Histone H3", pmod(mod:00430 ! "trimethylated residue", Lys, 27)) - pmid:25652642 + pubmed:19933700 - a(CHEBI:"amyloid-beta polypeptide 42") increases p(MESH:"I-kappa B Proteins", pmod(Ph)) + p(HGNC:HTT) causesNoChange p(CONSO:"Histone H3", pmod(mod:00429 ! "dimethylated residue", Lys, 27)) + + - pmid:29196815 + pubmed:19933700 - a(CHEBI:"amyloid-beta polypeptide 42") negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:HTT) increases complex(p(HGNC:EZH2), p(HGNC:HTT), p(HGNC:SUZ12)) + + + + + + + + - pmid:19293145 + pubmed:26968346 - a(CHEBI:"amyloid-beta polypeptide 42") association path(MESH:"Alzheimer Disease") + p(HGNC:HTT) association bp(GO:"selective autophagy") + + - pmid:19126755 + pubmed:14556719 - a(CHEBI:"amyloid-beta polypeptide 42") association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + p(HGNC:HTT) increases complex(p(HGNC:HTT), p(HGNC:UBA2)) - pmid:19126755 + pubmed:30985105 - a(CHEBI:"amyloid-beta polypeptide 42") regulates act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + p(HGNC:HTT) association bp(GO:"vesicle transport along microtubule") - pmid:19293145 + pubmed:30985105 - a(CHEBI:"amyloid-beta polypeptide 42") increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + p(HGNC:HTT) decreases bp(GO:"apoptotic process") + + + + - pmid:19126755 + pubmed:30663117 - a(CHEBI:"amyloid-beta polypeptide 42") increases complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7)) + g(HGNC:MIR196A1) association path(MESH:"Huntington Disease") - pmid:19126755 + pubmed:30663117 - a(CHEBI:"amyloid-beta polypeptide 42") decreases complex(a(MESH:methyllycaconitine), p(HGNC:CHRNA7)) + g(HGNC:MIR206) association path(MESH:"Huntington Disease") - pmid:19126755 + pubmed:30663117 - a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(HGNC:CHRNA7)) + g(HGNC:MIR301B) association path(MESH:"Huntington Disease") - pmid:19126755 + pubmed:30663117 - a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(HBP:"alpha-4 beta-2 nAChR")) + g(HGNC:MIR92B) association path(MESH:"Huntington Disease") - pmid:19126755 + pubmed:30663117 - a(CHEBI:"amyloid-beta polypeptide 42") decreases r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + g(HGNC:MIR378B) association path(MESH:"Huntington Disease") - pmid:25514383 + pubmed:30663117 - a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(MESH:"Synaptic Potentials") + g(HGNC:MIR208B) association path(MESH:"Huntington Disease") - pmid:25514383 + pubmed:30663117 - a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(MESH:"Synaptic Potentials") + g(HGNC:MIR449A) association path(MESH:"Huntington Disease") - pmid:25514383 + pubmed:30663117 - a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(FPLX:CHRN)) + g(HGNC:MIR22) decreases bp(GO:"neuron death") - pmid:25514383 + pubmed:16273023 - a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(FPLX:CHRN)) + act(a(CHEBI:acetylcholine)) association a(CHEBI:acetylcholine) - pmid:25514383 + pubmed:16273023 - a(CHEBI:"amyloid-beta polypeptide 42") decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + a(CHEBI:acetylcholine) association act(a(CHEBI:acetylcholine)) - pmid:25514383 + pubmed:17009926 - a(CHEBI:"amyloid-beta polypeptide 42") decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + deg(a(CHEBI:acetylcholine)) decreases act(a(CHEBI:acetylcholine)) - pmid:25514383 + pubmed:26218288 - a(CHEBI:"amyloid-beta polypeptide 42") decreases act(a(HBP:"alpha-4 beta-2 nAChR")) + a(CHEBI:acetylcholine) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:25514383 + pubmed:26218288 - a(CHEBI:"amyloid-beta polypeptide 42") increases bp(GO:"long-term synaptic potentiation") + a(CHEBI:acetylcholine) positiveCorrelation a(CHEBI:"ginsenoside Re") - pmid:19721446 + pubmed:26218288 - a(CHEBI:"amyloid-beta polypeptide 42") increases path(HBP:neurotoxicity) + a(CHEBI:acetylcholine) positiveCorrelation a(CHEBI:"ginsenoside Rd") - pmid:19721446 + pubmed:21673407 - a(CHEBI:"amyloid-beta polypeptide 42") increases path(HBP:neurotoxicity) + tloc(a(CHEBI:acetylcholine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association p(HGNC:HTR4) - pmid:22908190 + pubmed:19126755 - a(CHEBI:"amyloid-beta polypeptide 42") positiveCorrelation path(HBP:neurotoxicity) + a(CHEBI:acetylcholine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) - pmid:22908190 + pubmed:24590577 - a(CHEBI:"amyloid-beta polypeptide 42") increases path(HBP:neurotoxicity) + a(CHEBI:acetylcholine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) - pmid:19721446 + pubmed:19126755 - a(CHEBI:"amyloid-beta polypeptide 42") decreases act(a(CHEBI:nicotine)) + a(CHEBI:acetylcholine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:19721446 + pubmed:24590577 - a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(MESH:Neuroprotection) + a(CHEBI:acetylcholine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:14556719 + pubmed:19126755 - a(CHEBI:"amyloid-beta polypeptide 42") increases a(HBP:"amyloid-beta fibrils") + a(CHEBI:acetylcholine) decreases bp(MESH:"Heart Rate") - pmid:22908190 + pubmed:19126755 - tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:cytosol), toLoc(GO:lysosome)) positiveCorrelation bp(GO:endocytosis) + a(CHEBI:acetylcholine) association bp(GO:signaling) - pmid:22908190 + pubmed:24511233 - tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:cytosol), toLoc(GO:lysosome)) positiveCorrelation g(HBP:"APOE e4") + a(CHEBI:acetylcholine) regulates act(a(MESH:Neurons)) - pmid:22908190 + pubmed:24511233 - tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:cytosol), toLoc(GO:lysosome)) positiveCorrelation a(CHEBI:"low-density lipoprotein cholesterol") + act(a(CHEBI:acetylcholine)) increases act(p(HGNC:CHRM4)) - pmid:22908190 + pubmed:17009926 - a(CHEBI:"amyloid-beta polypeptide 42") positiveCorrelation a(CHEBI:"amyloid-beta") + a(CHEBI:acetylcholine) increases act(p(HGNC:CHRNA7)) - pmid:26195256 + pubmed:26979166 - a(CHEBI:"amyloid-beta polypeptide 42") isA a(CHEBI:"amyloid-beta") + a(CHEBI:acetylcholine) increases act(p(HGNC:CHRNA7, loc(MESH:Microglia))) + + + + - pmid:30116051 + pubmed:17009926 - a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(FPLX:AMPK)) + a(CHEBI:acetylcholine) increases bp(GO:"regulation of action potential firing rate") - pmid:22419736 + pubmed:26813123 - a(CHEBI:"amyloid-beta polypeptide 42") causesNoChange p(FPLX:AMPK) + a(CHEBI:acetylcholine) isA a(CHEBI:neurotransmitter) - pmid:22419736 + pubmed:26813123 - a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(FPLX:AMPK)) + a(CHEBI:acetylcholine) positiveCorrelation bp(GO:memory) - pmid:22419736 + pubmed:26813123 - a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(FPLX:AMPK)) + a(CHEBI:acetylcholine) regulates bp(GO:memory) - pmid:30116051 + pubmed:26813123 - a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(GO:"autophagosome assembly") + a(CHEBI:acetylcholine) association bp(GO:memory) - pmid:30116051 + pubmed:26813123 - a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + a(CHEBI:acetylcholine) regulates a(MESH:"Hypothalamo-Hypophyseal System") - pmid:30116051 + pubmed:26813123 - a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(GO:"chaperone-mediated autophagy") + a(CHEBI:acetylcholine) increases act(a(MESH:"Receptors, Nicotinic")) - pmid:30116051 + pubmed:26813123 - a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(GO:"chaperone-mediated autophagy") + a(CHEBI:acetylcholine) increases bp(GO:"response to auditory stimulus") - pmid:30116051 + pubmed:26813123 - a(CHEBI:"amyloid-beta polypeptide 42") decreases a(GO:microtubule) + a(CHEBI:acetylcholine) increases bp(GO:"synaptic transmission, cholinergic") - pmid:30116051 + pubmed:26813123 - a(CHEBI:"amyloid-beta polypeptide 42") decreases p(HGNC:IDE) + a(CHEBI:acetylcholine) increases bp(GO:neurogenesis) - pmid:22419736 + pubmed:26813123 - a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:AK1) + a(CHEBI:acetylcholine) increases act(p(FPLX:CHRM)) - pmid:22419736 + pubmed:21482353 - a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:AK1) + a(CHEBI:acetylcholine) increases act(p(FPLX:CHRM)) - pmid:22419736 + pubmed:26813123 - a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) + a(CHEBI:acetylcholine) increases act(p(FPLX:CHRN)) - pmid:22419736 + pubmed:21482353 - a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) + a(CHEBI:acetylcholine) increases act(p(FPLX:CHRN)) - pmid:22419736 + pubmed:21787755 - a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + a(CHEBI:acetylcholine) increases act(p(FPLX:CHRN)) - pmid:22419736 + pubmed:26813123 - a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + deg(a(CHEBI:acetylcholine)) increases a(CHEBI:choline) - pmid:22419736 + pubmed:26813123 - a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + a(CHEBI:acetylcholine) regulates bp(MESH:"Synaptic Transmission") - pmid:22419736 + pubmed:26813123 - a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + a(CHEBI:acetylcholine) regulates bp(GO:"synaptic transmission, glutamatergic") - pmid:22419736 + pubmed:26813123 - a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + a(CHEBI:acetylcholine) association bp(GO:learning) - pmid:22419736 + pubmed:26813123 - a(CHEBI:"amyloid-beta polypeptide 42") causesNoChange act(p(HGNC:AK3)) + a(CHEBI:acetylcholine) association bp(GO:cognition) - pmid:22419736 + pubmed:11230871 - a(CHEBI:"amyloid-beta polypeptide 42") increases r(HGNC:AK1) + a(CHEBI:acetylcholine) negativeCorrelation bp(GO:cognition) + + - pmid:22419736 + pubmed:16273023 - a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(Ph, Ser, 231)) + a(CHEBI:acetylcholine) increases complex(a(CHEBI:acetylcholine), p(MESH:D011950)) + + + + - pmid:22419736 + pubmed:25514383 - a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(Ph, Thr, 235)) + tloc(a(CHEBI:acetylcholine), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) regulates bp(GO:"long-term memory") + + + + - pmid:22419736 + pubmed:25514383 - a(CHEBI:"amyloid-beta polypeptide 42") decreases p(FPLX:AMPK, pmod(Ph, Thr, 172)) + a(CHEBI:acetylcholine) increases act(p(CONSO:"beta-2-containing nAChR")) - pmid:22419736 + pubmed:25514383 - a(CHEBI:"amyloid-beta polypeptide 42") decreases p(FPLX:AMPK, pmod(Ph, Thr, 172)) + act(a(CHEBI:acetylcholine)) increases act(p(CONSO:"alpha-4 beta-2 nAChR")) + + - pmid:22419736 + pubmed:28445721 - a(CHEBI:"amyloid-beta polypeptide 42") decreases p(MESH:"Acetyl-CoA Carboxylase", pmod(Ph)) + a(CHEBI:acetylcholine) increases act(a(MESH:"nicotinic receptor alpha3beta4")) - pmid:22419736 + pubmed:21482353 - a(CHEBI:"amyloid-beta polypeptide 42") decreases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) + a(CHEBI:acetylcholine) increases act(p(CONSO:"alpha-7-containing nAChR")) - pmid:26195256 + pubmed:19721446 - a(CHEBI:"amyloid-beta polypeptide 42", loc(MESH:"Cerebrospinal Fluid")) negativeCorrelation a(HBP:"amyloid-beta aggregates", loc(GO:"extracellular region")) + a(CHEBI:acetylcholine) association bp(GO:"regulation of cation channel activity") - pmid:29626319 + pubmed:19721446 - a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:TREM2) + a(CHEBI:acetylcholine) increases bp(GO:"potassium ion transport") - pmid:30444369 + pubmed:19721446 - p(FPLX:"Gamma_secretase") increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta polypeptide 42"), p(HBP:"APP C-terminally truncated carboxyl-terminal fragments"))) + a(CHEBI:acetylcholine) increases bp(GO:"sodium ion transport") - pmid:26195256 + pubmed:19721446 - p(FPLX:"Gamma_secretase") increases deg(a(HBP:"APP C-terminally truncated carboxyl-terminal fragments")) + a(CHEBI:acetylcholine) increases bp(GO:"calcium ion transport") - pmid:29179999 + pubmed:16273023 - a(CHEBI:lycopene) increases path(MESH:"Spatial Learning") + a(CL:"cholinergic neuron") negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:29179999 + pubmed:16273023 - a(CHEBI:lycopene) increases bp(GO:memory) + act(p(HGNC:ACHE)) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:29179999 + pubmed:26813123 - a(CHEBI:lycopene) decreases bp(GO:"NIK/NF-kappaB signaling") + p(HGNC:ACHE) association path(MESH:"Alzheimer Disease") - pmid:29179999 + pubmed:11230871 - a(CHEBI:genistein) decreases p(HGNC:TLR4) + act(p(HGNC:ACHE)) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:29179999 + pubmed:3484831 - a(CHEBI:genistein) decreases p(FPLX:NFkappaB) + p(HGNC:ACHE) positiveCorrelation a(NIFT:"Cerebral atrophy") - pmid:29179999 + pubmed:3484831 - a(CHEBI:genistein) decreases act(p(FPLX:NFkappaB)) + p(HGNC:ACHE) positiveCorrelation a(NIFT:"Cerebral atrophy") - pmid:29179999 + pubmed:19126755 - a(CHEBI:genistein) decreases complex(a(MESH:DNA), p(FPLX:NFkappaB)) + p(HGNC:ACHE) decreases act(a(CHEBI:nicotine)) - pmid:19293145 + pubmed:19126755 - a(CHEBI:genistein) decreases act(a(CHEBI:"amyloid-beta")) + act(p(HGNC:ACHE)) decreases a(MESH:Acetylcholine) - pmid:19293145 + pubmed:19293145 - a(CHEBI:genistein) decreases act(a(CHEBI:"L-glutamate(2-)")) + p(HGNC:ACHE) decreases a(CHEBI:acetylcholine) - pmid:19293145 + pubmed:17009926 - a(CHEBI:genistein) decreases p(HGNC:CHRNA7, pmod(Ph)) + act(p(HGNC:ACHE), ma(go:0008233 ! "peptidase activity")) directlyIncreases deg(a(CHEBI:acetylcholine)) - pmid:17009926 + pubmed:26813123 - a(CHEBI:genistein) decreases p(HGNC:CHRNA7, pmod(Ph)) + p(HGNC:ACHE) decreases act(a(CHEBI:acetylcholine)) - pmid:17009926 + pubmed:21482353 - a(CHEBI:genistein) causesNoChange surf(p(FPLX:CHRN)) + p(HGNC:ACHE) increases deg(a(CHEBI:acetylcholine)) - pmid:17009926 + pubmed:23038257 - a(CHEBI:genistein) regulates p(FPLX:CHRN) + p(HGNC:ACHE) increases act(a(CHEBI:chlorpromazine)) - pmid:27314526 + pubmed:17009926 - p(HGNC:TLR4) increases bp(GO:"cytokine secretion") + act(p(HGNC:ACHE), ma(go:0008233 ! "peptidase activity")) directlyIncreases rxn(reactants(a(CHEBI:acetylcholine)), products(a(CHEBI:acetate), a(CHEBI:choline))) - pmid:29179999 + pubmed:26813123 - a(PUBCHEM:45270574) decreases act(a(CHEBI:"amyloid-beta polypeptide 42")) + p(HGNC:ACHE) increases rxn(reactants(a(CHEBI:acetylcholine)), products(a(CHEBI:acetate), a(CHEBI:choline))) + + - pmid:29179999 + pubmed:26813123 - a(CHEBI:"gallic acid") decreases act(p(FPLX:MYST)) + p(HGNC:ACHE) increases a(CHEBI:amyloid-beta) - pmid:29179999 + pubmed:25514383 - a(CHEBI:"gallic acid") decreases p(HGNC:RELA, pmod(Ac)) + act(p(HGNC:ACHE)) increases bp(GO:"acetylcholine catabolic process") - pmid:29179999 + pubmed:21482353 - a(CHEBI:"gallic acid") decreases path(MESH:Inflammation) + act(p(HGNC:ACHE)) decreases bp(GO:"synaptic transmission, cholinergic") - pmid:29179999 + pubmed:18986241 - a(CHEBI:"gallic acid") decreases act(p(FPLX:NFkappaB)) + p(HGNC:ACHE) association path(MESH:"Plaque, Amyloid") - pmid:29179999 + pubmed:18986241 - a(CHEBI:"gallic acid") decreases act(a(CHEBI:"amyloid-beta")) + p(HGNC:ACHE) increases bp(GO:"amyloid fibril formation") + + - pmid:29179999 + pubmed:16273023 - a(CHEBI:galanthamine) decreases act(p(HGNC:ACHE)) + p(HGNC:REST) association path(MESH:"Alzheimer Disease") - pmid:19126755 + pubmed:16273023 - a(CHEBI:galanthamine) decreases p(HGNC:ACHE) + p(HGNC:REST) association path(MESH:Stroke) - pmid:11230871 + pubmed:16273023 - a(CHEBI:galanthamine) decreases act(p(HGNC:ACHE)) + p(HGNC:REST) association path(MESH:Epilepsy) - pmid:29179999 + pubmed:16273023 - a(CHEBI:galanthamine) increases a(CHEBI:acetylcholine) + p(HGNC:REST) negativeCorrelation tloc(a(CHEBI:"insulin (human)"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:29179999 + pubmed:16273023 - a(CHEBI:galanthamine) increases sec(a(CHEBI:acetylcholine)) + p(HGNC:REST) decreases a(CHEBI:"insulin (human)") - pmid:29179999 + pubmed:16273023 - a(CHEBI:galanthamine) increases act(p(HGNC:HMOX1)) + path(MESH:Stroke) association p(HGNC:REST) - pmid:29179999 + pubmed:24561250 - a(CHEBI:galanthamine) increases act(p(FPLX:NFkappaB)) + path(MESH:Stroke) increases complex(GO:"inflammasome complex") - pmid:30444369 + pubmed:16273023 - a(CHEBI:galanthamine) increases bp(GO:cognition) + path(MESH:Epilepsy) association p(HGNC:REST) - pmid:26813123 + pubmed:17009926 - a(CHEBI:galanthamine) increases bp(GO:cognition) + path(MESH:Epilepsy) association p(FPLX:CHRN) - pmid:30444369 + pubmed:17009926 - a(CHEBI:galanthamine) decreases act(p(FPLX:Cholinesterase)) + path(MESH:Epilepsy) association p(FPLX:CHRN) - pmid:19126755 + pubmed:11230871 - a(CHEBI:galanthamine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + path(MESH:Epilepsy) association p(FPLX:CHRN) - pmid:19126755 + pubmed:21482353 - a(CHEBI:galanthamine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + path(MESH:Epilepsy) positiveCorrelation p(HGNC:CHRNA4, var("?")) - pmid:19126755 + pubmed:21482353 - a(CHEBI:galanthamine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + path(MESH:Epilepsy) positiveCorrelation p(HGNC:CHRNB2, var("?")) - pmid:19126755 + pubmed:21787755 - a(CHEBI:galanthamine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + path(MESH:Epilepsy) association complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) - pmid:19293145 + pubmed:28901280 - a(CHEBI:galanthamine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + path(MESH:Epilepsy) association p(MESH:"Receptors, Nicotinic") - pmid:19126755 + pubmed:16273023 - a(CHEBI:galanthamine) decreases path(HBP:Neurodegeneration) + tloc(a(CHEBI:"insulin (human)"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) negativeCorrelation p(HGNC:REST) - pmid:19126755 + pubmed:22908190 - a(CHEBI:galanthamine) increases bp(GO:"synaptic transmission, cholinergic") + a(CHEBI:"insulin (human)") regulates p(HGNC:MTOR) - pmid:19293145 + pubmed:16273023 - a(CHEBI:galanthamine) isA a(CHEBI:"EC 3.1.1.8 (cholinesterase) inhibitor") + p(RGD:Gsk3b) regulates p(HGNCGENEFAMILY:"Glutamate ionotropic receptor AMPA type subunits") - pmid:19293145 + pubmed:16273023 - a(CHEBI:galanthamine) decreases path(MESH:"Alzheimer Disease") + p(RGD:Gsk3b) increases bp(MESH:"Long-Term Synaptic Depression") + + + + + + + + + + - pmid:19293145 + pubmed:16273023 - act(a(CHEBI:galanthamine)) increases bp(MESH:Neuroprotection) + p(HGNCGENEFAMILY:"Protein phosphatase catalytic subunits") increases p(RGD:Gsk3b) - pmid:19293145 + pubmed:18986241 - a(CHEBI:galanthamine) increases p(HGNC:BCL2) + p(HGNCGENEFAMILY:"Protein phosphatase catalytic subunits") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:24511233 + pubmed:18986241 - a(CHEBI:galanthamine) isA a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") + act(p(HGNCGENEFAMILY:"Protein phosphatase catalytic subunits")) decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:17009926 + pubmed:16273023 - a(CHEBI:galanthamine) isA a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") + p(HGNC:SEPT2) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:17009926 + pubmed:16273023 - a(CHEBI:galanthamine) increases act(p(FPLX:CHRN)) + p(HGNC:SEPT2) regulates bp(MESH:"Neuronal Plasticity") - pmid:11230871 + pubmed:16273023 - a(CHEBI:galanthamine) increases act(p(FPLX:CHRN)) + p(HGNC:SEPT2) association p(HGNC:SLC1A3) - pmid:11230871 + pubmed:16273023 - a(CHEBI:galanthamine) increases p(FPLX:CHRN) + p(HGNC:SEPT3) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:26813123 + pubmed:16273023 - a(CHEBI:galanthamine) decreases path(MESH:Death) + p(HGNC:SEPT5) negativeCorrelation path(MESH:"Alzheimer Disease") - - - pmid:25881725 - - a(CHEBI:galanthamine) decreases act(p(MGI:App, frag("25_35"))) - + - pmid:25881725 + pubmed:14556719 - a(CHEBI:galanthamine) increases bp(GO:learning) + p(HGNC:SEPT5) decreases tloc(a(CHEBI:"growth hormone"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:25881725 + pubmed:14556719 - a(CHEBI:galanthamine) increases path(MESH:"Spatial Memory") + p(HGNC:SEPT5) regulates tloc(a(CHEBI:neurotransmitter), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:25881725 + pubmed:14556719 - a(CHEBI:galanthamine) causesNoChange r(MGI:Chrna7) + p(HGNC:SEPT5) regulates act(a(GO:"synaptic vesicle")) - pmid:25881725 + pubmed:16273023 - a(CHEBI:galanthamine) increases p(MGI:Chrna7) + p(RGD:Sept5) association p(RGD:Stx1a) - pmid:25881725 + pubmed:16273023 - a(CHEBI:galanthamine) increases p(MGI:Chrna7) + p(RGD:Sept5) decreases bp(GO:exocytosis) - - - pmid:19721446 - - a(CHEBI:galanthamine) regulates p(HGNC:CHRNA7) - + - pmid:19721446 + pubmed:16273023 - a(CHEBI:galanthamine) decreases path(MESH:Schizophrenia) + act(p(RGD:Sept5)) negativeCorrelation act(p(RGD:Cdk5)) - pmid:19126755 + pubmed:16273023 - p(HGNC:ACHE) decreases act(a(CHEBI:nicotine)) + p(RGD:Stx1a) association p(RGD:Sept5) - pmid:19126755 + pubmed:16273023 - act(p(HGNC:ACHE)) decreases a(MESH:Acetylcholine) + p(RGD:Stx1a) association bp(GO:exocytosis) - pmid:19293145 + pubmed:16273023 - p(HGNC:ACHE) decreases a(CHEBI:acetylcholine) + bp(GO:exocytosis) association p(RGD:Stx1a) - pmid:17009926 + pubmed:16273023 - act(p(HGNC:ACHE), ma(pep)) directlyIncreases deg(a(CHEBI:acetylcholine)) + p(RGD:Cdk5) increases p(RGD:Sept5, pmod(go:0006468 ! "protein phosphorylation", Ser, 161)) - pmid:26813123 + pubmed:16273023 - p(HGNC:ACHE) decreases act(a(CHEBI:acetylcholine)) + p(RGD:Cdk5) increases p(RGD:Sept5, pmod(go:0006468 ! "protein phosphorylation", Ser, 327)) - pmid:21482353 + pubmed:16273023 - p(HGNC:ACHE) increases deg(a(CHEBI:acetylcholine)) + act(p(RGD:Cdk5)) negativeCorrelation act(p(RGD:Sept5)) - pmid:23038257 + pubmed:27807169 - p(HGNC:ACHE) increases act(a(CHEBI:chlorpromazine)) + act(p(RGD:Cdk5)) positiveCorrelation bp(GO:"neuron differentiation") - pmid:17009926 + pubmed:21489990 - act(p(HGNC:ACHE), ma(pep)) directlyIncreases rxn(reactants(a(CHEBI:acetylcholine)), products(a(CHEBI:acetate), a(CHEBI:choline))) + act(p(RGD:Cdk5)) increases p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) - pmid:26813123 + pubmed:21489990 - p(HGNC:ACHE) increases rxn(reactants(a(CHEBI:acetylcholine)), products(a(CHEBI:acetate), a(CHEBI:choline))) + act(p(RGD:Cdk5)) increases p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) - pmid:26813123 + pubmed:21489990 - p(HGNC:ACHE) association path(MESH:"Alzheimer Disease") + act(p(RGD:Cdk5)) increases p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) - pmid:11230871 + pubmed:24107444 - act(p(HGNC:ACHE)) negativeCorrelation path(MESH:"Alzheimer Disease") + bp(MESH:"Neuronal Plasticity") positiveCorrelation p(MGI:Psen1) - pmid:26813123 + pubmed:24107444 - p(HGNC:ACHE) increases a(CHEBI:"amyloid-beta") + bp(MESH:"Neuronal Plasticity") positiveCorrelation a(CHEBI:"calcium(2+)") - pmid:25514383 + pubmed:19126755 - act(p(HGNC:ACHE)) increases bp(GO:"acetylcholine catabolic process") + bp(MESH:"Neuronal Plasticity") association act(p(FPLX:CREB)) - pmid:21482353 + pubmed:19126755 - act(p(HGNC:ACHE)) decreases bp(GO:"synaptic transmission, cholinergic") + bp(MESH:"Neuronal Plasticity") association act(p(HGNC:MAPK1)) - pmid:18986241 + pubmed:29428175 - p(HGNC:ACHE) association path(MESH:D058225) + bp(MESH:"Neuronal Plasticity") association p(MESH:"Receptors, Glutamate", loc(GO:"postsynaptic membrane")) - pmid:18986241 + pubmed:30697142 - p(HGNC:ACHE) increases bp(GO:"GO:1990000") + bp(MESH:"Neuronal Plasticity") association bp(GO:"learning or memory") - pmid:19126755 + pubmed:18986241 - a(CHEBI:acetylcholine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) + bp(MESH:"Neuronal Plasticity") association act(p(HGNC:GAL)) - pmid:24590577 + pubmed:24760868 - a(CHEBI:acetylcholine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) + bp(MESH:"Neuronal Plasticity") association tloc(p(HGNC:MAPT), fromLoc(GO:"dendritic shaft"), toLoc(GO:synapse)) - pmid:19126755 + pubmed:28420982 - a(CHEBI:acetylcholine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + bp(MESH:"Neuronal Plasticity") increases tloc(p(HGNC:MAPT), fromLoc(GO:cell), toLoc(GO:cell)) - pmid:24590577 + pubmed:28420982 - a(CHEBI:acetylcholine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + bp(MESH:"Neuronal Plasticity") association a(CONSO:"Tau aggregates") - pmid:19126755 + pubmed:16273023 - a(CHEBI:acetylcholine) decreases bp(MESH:"Heart Rate") + p(HGNC:SLC1A3) association p(HGNC:SEPT2) - pmid:19126755 + pubmed:17361039 - a(CHEBI:acetylcholine) association bp(GO:signaling) + p(HGNC:SLC1A3) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:24511233 + pubmed:17361039 - a(CHEBI:acetylcholine) regulates act(a(MESH:Neurons)) + p(HGNC:SLC1A3) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:24511233 + pubmed:23340677 - act(a(CHEBI:acetylcholine)) increases act(p(HGNC:CHRM4)) + p(MGI:Mapt) positiveCorrelation a(CHEBI:"L-glutamic acid") - pmid:17009926 + pubmed:23340677 - deg(a(CHEBI:acetylcholine)) decreases act(a(CHEBI:acetylcholine)) + p(MGI:Mapt) negativeCorrelation bp(MESH:Metabolism) + + - pmid:17009926 + pubmed:21427723 - a(CHEBI:acetylcholine) increases act(p(HGNC:CHRNA7)) + p(MGI:Mapt) decreases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation")) - - - pmid:17009926 - - a(CHEBI:acetylcholine) increases bp(GO:"regulation of action potential firing rate") - + + + - pmid:26813123 + pubmed:21427723 - a(CHEBI:acetylcholine) isA a(CHEBI:neurotransmitter) + p(MGI:Mapt) increases p(CONSO:"Tau fibrils") - pmid:26813123 + pubmed:21427723 - a(CHEBI:acetylcholine) positiveCorrelation bp(GO:memory) + p(MGI:Mapt) decreases p(CONSO:"Tau fibrils") - - - pmid:26813123 - - a(CHEBI:acetylcholine) regulates bp(GO:memory) - + - - - pmid:26813123 - - a(CHEBI:acetylcholine) association bp(GO:memory) - + - - - pmid:26813123 - - a(CHEBI:acetylcholine) regulates a(MESH:"Hypothalamo-Hypophyseal System") - + - pmid:26813123 + pubmed:21427723 - a(CHEBI:acetylcholine) increases act(a(MESH:"Receptors, Nicotinic")) + act(p(MGI:Mapt)) increases a(MESH:Microtubules) - pmid:26813123 + pubmed:21427723 - a(CHEBI:acetylcholine) increases bp(GO:"response to auditory stimulus") + act(p(MGI:Mapt)) positiveCorrelation bp(GO:"microtubule bundle formation") - - - pmid:26813123 - - a(CHEBI:acetylcholine) increases bp(GO:"synaptic transmission, cholinergic") - + - - - pmid:26813123 - - a(CHEBI:acetylcholine) increases bp(GO:neurogenesis) - + - - - pmid:26813123 - - a(CHEBI:acetylcholine) increases act(p(FPLX:CHRM)) - + - - - pmid:21482353 - - a(CHEBI:acetylcholine) increases act(p(FPLX:CHRM)) - + - - - pmid:26813123 - - a(CHEBI:acetylcholine) increases act(p(FPLX:CHRN)) - + - - - pmid:21482353 - - a(CHEBI:acetylcholine) increases act(p(FPLX:CHRN)) - + + + + + + + + + - pmid:21787755 + pubmed:29024336 - a(CHEBI:acetylcholine) increases act(p(FPLX:CHRN)) + p(MGI:Mapt) decreases bp(GO:"late endosomal microautophagy") + + + + + + + + + + + + + + - pmid:26813123 + pubmed:29202785 - deg(a(CHEBI:acetylcholine)) increases a(CHEBI:choline) + p(MGI:Mapt) increases bp(GO:"neuron migration") - pmid:26813123 + pubmed:29202785 - a(CHEBI:acetylcholine) regulates bp(MESH:"Synaptic Transmission") + p(MGI:Mapt) increases bp(GO:"neuron differentiation") - pmid:26813123 + pubmed:29202785 - a(CHEBI:acetylcholine) regulates bp(GO:"synaptic transmission, glutamatergic") + p(MGI:Mapt) increases bp(GO:"neuron maturation") + + + + + + - pmid:26813123 + pubmed:30126037 - a(CHEBI:acetylcholine) association bp(GO:learning) + p(MGI:Mapt) increases a(GO:"neurofibrillary tangle") - pmid:26813123 + pubmed:30126037 - a(CHEBI:acetylcholine) association bp(GO:cognition) + p(MGI:Mapt) increases bp(HP:Neurodegeneration) - pmid:11230871 + pubmed:30126037 - a(CHEBI:acetylcholine) negativeCorrelation bp(GO:cognition) + p(MGI:Mapt) increases p(MGI:Cdkn2a) - pmid:16273023 + pubmed:30126037 - a(CHEBI:acetylcholine) increases complex(a(CHEBI:acetylcholine), p(MESH:D011950)) + p(MGI:Mapt) increases bp(GO:"cellular senescence") - pmid:25514383 + pubmed:30126037 - tloc(a(CHEBI:acetylcholine), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) regulates bp(GO:"long-term memory") + p(MGI:Mapt) increases path(HP:"Brain atrophy") + + + + - pmid:25514383 + pubmed:28408124 - a(CHEBI:acetylcholine) increases act(a(HBP:"beta-2-containing nAChR")) + tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) increases a(CONSO:"Tau aggregates") + + + + + + + + + + + + + + + + + + + + + + + + + + - pmid:25514383 + pubmed:18096814 - act(a(CHEBI:acetylcholine)) increases act(a(HBP:"alpha-4 beta-2 nAChR")) + p(MGI:Mapt, loc(GO:"membrane raft")) negativeCorrelation a(CHEBI:"2-bromohexadecanoic acid") + + + + + + - pmid:28445721 + pubmed:19118186 - a(CHEBI:acetylcholine) increases act(a(MESH:"nicotinic receptor alpha3beta4")) + p(MGI:Mapt) negativeCorrelation bp(GO:memory) + + - pmid:21482353 + pubmed:29221819 - a(CHEBI:acetylcholine) increases act(a(HBP:"alpha-7-containing nAChR")) + p(MGI:Mapt) positiveCorrelation p(MGI:Dyrk1a) - pmid:19721446 + pubmed:28877763 - a(CHEBI:acetylcholine) association bp(GO:"regulation of cation channel activity") + p(MGI:Mapt) positiveCorrelation p(MGI:Syk) + + + + + + + + + + + + + + + + + + + + + + + + + + + + - pmid:19721446 + pubmed:23340677 - a(CHEBI:acetylcholine) increases bp(GO:"potassium ion transport") + a(CHEBI:"L-glutamic acid") positiveCorrelation p(MGI:Mapt) - pmid:19721446 + pubmed:24107444 - a(CHEBI:acetylcholine) increases bp(GO:"sodium ion transport") + tloc(a(CHEBI:"L-glutamic acid"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) positiveCorrelation p(MGI:Psen1) - pmid:19721446 + pubmed:24107444 - a(CHEBI:acetylcholine) increases bp(GO:"calcium ion transport") + tloc(a(CHEBI:"L-glutamic acid"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) positiveCorrelation a(CHEBI:"calcium(2+)") - - - - - pmid:29179999 + pubmed:23340677 - complex(a(CHEBI:galanthamine), p(FPLX:CHRN)) increases act(p(FPLX:CHRN)) + bp(MESH:Metabolism) negativeCorrelation p(MGI:Mapt) - pmid:17009926 + pubmed:" 23273601" - p(FPLX:CHRN) increases bp(GO:"neurotransmitter secretion") + r(HGNC:VAMP2) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:17009926 + pubmed:" 23273601" - act(p(FPLX:CHRN)) increases bp(GO:"neurotransmitter secretion") + r(HGNC:SNAP25) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:17009926 + pubmed:" 23273601" - p(FPLX:CHRN) increases bp(GO:"neurotransmitter secretion") + r(HGNC:SYN1) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:17009926 + pubmed:" 23273601" - p(FPLX:CHRN) regulates bp(GO:"rhythmic excitation") + r(HGNC:SYN2) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:17009926 + pubmed:" 23273601" - p(FPLX:CHRN) regulates bp(GO:"rhythmic excitation") + r(HGNC:SYT1) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:17009926 + pubmed:" 23273601" - p(FPLX:CHRN) regulates bp(GO:"neuron remodeling") + r(HGNC:SYT5) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:17009926 + pubmed:" 23273601" - p(FPLX:CHRN) association bp(GO:"regulation of synaptic plasticity") + r(HGNC:DNM1) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:17009926 + pubmed:" 23273601" - act(p(FPLX:CHRN)) increases bp(GO:"regulation of synaptic plasticity") + r(HGNC:DNM1L) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:17009926 + pubmed:" 23273601" - p(FPLX:CHRN) association bp(GO:"regulation of synaptic plasticity") + r(HGNC:SYNPO) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:17009926 + pubmed:" 23273601" - p(FPLX:CHRN) association path(MESH:Attention) + r(HGNC:RAB3A) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:17009926 + pubmed:" 23273601" - p(FPLX:CHRN) association bp(GO:learning) + r(HGNC:SEC22B) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:17009926 + pubmed:" 23273601" - p(FPLX:CHRN) association bp(GO:memory) + r(HGNC:SNCB) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:11230871 + pubmed:" 23273601" - p(FPLX:CHRN) association bp(GO:memory) + r(HGNC:STXBP5L) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:17009926 + pubmed:" 23273601" - p(FPLX:CHRN) association bp(GO:"developmental process") + r(HGNC:STXBP6) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:17009926 + pubmed:" 23273601" - p(FPLX:CHRN) association path(MESH:Schizophrenia) + r(HGNC:BSN) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:17009926 + pubmed:" 23273601" - p(FPLX:CHRN) association path(MESH:Schizophrenia) + r(HGNC:PCLO) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:21482353 + pubmed:" 23273601" - act(p(FPLX:CHRN)) association path(MESH:Schizophrenia) + r(HGNC:SNAP23) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:11230871 + pubmed:" 23273601" - p(FPLX:CHRN) association path(MESH:Schizophrenia) + r(HGNC:SYNPO2) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:17009926 + pubmed:" 23273601" - p(FPLX:CHRN) association path(MESH:Epilepsy) + r(HGNC:VAMP1) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:17009926 + pubmed:26218288 - p(FPLX:CHRN) association path(MESH:Epilepsy) + p(RGD:App) decreases r(RGD:Grin1) - pmid:11230871 + pubmed:26218288 - p(FPLX:CHRN) association path(MESH:Epilepsy) + p(RGD:App) decreases r(RGD:Grm1) - pmid:17009926 + pubmed:26218288 - p(FPLX:CHRN) association path(MESH:"Autistic Disorder") + p(RGD:App) decreases r(RGD:Kcnj6) - pmid:17009926 + pubmed:26218288 - act(p(FPLX:CHRN)) negativeCorrelation path(MESH:"Autistic Disorder") + p(RGD:App) decreases r(RGD:Kcnj9) - pmid:17009926 + pubmed:26218288 - p(FPLX:CHRN) negativeCorrelation path(MESH:"Autistic Disorder") + p(RGD:App) decreases r(RGD:Kcnj5) - pmid:17009926 + pubmed:26218288 - p(FPLX:CHRN) association path(MESH:"Alzheimer Disease") + p(RGD:App) decreases r(RGD:Kcnq2) - pmid:17009926 + pubmed:26218288 - act(p(FPLX:CHRN)) negativeCorrelation path(MESH:"Alzheimer Disease") + p(RGD:App) decreases r(RGD:Kcnq3) - pmid:17009926 + pubmed:26218288 - p(FPLX:CHRN) negativeCorrelation path(MESH:"Alzheimer Disease") + path(HP:"Neuronal loss in central nervous system") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:17009926 + pubmed:26218288 - p(FPLX:CHRN) negativeCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:"ginsenoside Re") increases r(MGI:Chat) - pmid:11230871 + pubmed:26218288 - p(FPLX:CHRN) association path(MESH:"Alzheimer Disease") + a(CHEBI:"ginsenoside Re") increases r(MGI:Slc18a3) - pmid:11230871 + pubmed:26218288 - p(FPLX:CHRN) negativeCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:"ginsenoside Re") positiveCorrelation a(CHEBI:acetylcholine) - pmid:17009926 + pubmed:26218288 - p(FPLX:CHRN) association path(MESH:"Behavior, Addictive") + a(CHEBI:"ginsenoside Re") increases p(MGI:Map2) - pmid:26472524 + pubmed:26218288 - act(p(FPLX:CHRN)) increases path(MESH:"Behavior, Addictive") + a(CHEBI:"ginsenoside Re") increases p(MGI:Ngfr) - pmid:17009926 + pubmed:26218288 - p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Monovalent"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + a(CHEBI:"ginsenoside Re") increases p(MGI:Cdkn1a) - pmid:17009926 + pubmed:26218288 - p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Monovalent"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) + a(CHEBI:"ginsenoside Re") increases p(MGI:Ntrk1) - pmid:26472524 + pubmed:26218288 - p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Monovalent"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + a(CHEBI:"ginsenoside Rd") increases r(MGI:Chat) - pmid:26472524 + pubmed:26218288 - p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Monovalent"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) + a(CHEBI:"ginsenoside Rd") increases r(MGI:Slc18a3) - pmid:17009926 + pubmed:26218288 - p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Divalent"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + a(CHEBI:"ginsenoside Rd") positiveCorrelation a(CHEBI:acetylcholine) - pmid:17009926 + pubmed:26218288 - p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Divalent"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) + a(CHEBI:"ginsenoside Rd") increases p(MGI:Map2) - pmid:26472524 + pubmed:26218288 - p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Divalent"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + a(CHEBI:"ginsenoside Rd") increases p(MGI:Ngfr) - pmid:26472524 + pubmed:26218288 - p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Divalent"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) + a(CHEBI:"ginsenoside Rd") increases p(MGI:Cdkn1a) - pmid:17009926 + pubmed:26218288 - act(p(FPLX:CHRN)) increases bp(GO:"membrane depolarization") + a(CHEBI:"ginsenoside Rd") increases p(MGI:Ntrk1) - pmid:17009926 + pubmed:26218288 - act(p(FPLX:CHRN)) increases bp(GO:"membrane depolarization") + a(CHEBI:K-252a) decreases p(MGI:Mapk1) - pmid:17009926 + pubmed:26218288 - act(p(FPLX:CHRN)) increases bp(GO:"membrane depolarization") + a(CHEBI:K-252a) decreases p(MGI:Akt1) - pmid:26472524 + pubmed:26218288 - act(p(FPLX:CHRN)) increases bp(GO:"membrane depolarization") + a(CHEBI:K-252a) decreases p(MGI:Ntrk1) - pmid:17009926 + pubmed:24107444 - act(p(FPLX:CHRN)) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + g(HGNC:PSEN1) negativeCorrelation path(MESH:"Alzheimer Disease") + + - pmid:26472524 + pubmed:24107444 - p(FPLX:CHRN) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + p(HGNC:PSEN1) isA complex(GO:"gamma-secretase complex") - pmid:26472524 + pubmed:23091460 - p(FPLX:CHRN) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) + p(HGNC:PSEN1) positiveCorrelation act(p(HGNCGENEFAMILY:"V-type ATPases")) - pmid:25514383 + pubmed:23091460 - act(p(FPLX:CHRN)) increases a(CHEBI:"calcium(2+)") + p(HGNC:PSEN1) positiveCorrelation bp(GO:autophagy) - pmid:17009926 + pubmed:30688256 - act(p(FPLX:CHRN)) increases sec(a(CHEBI:"glutamate(2-)")) + act(p(HGNC:PSEN1)) increases bp(GO:autophagy) + + - pmid:17009926 + pubmed:21214928 - p(FPLX:CHRN) increases sec(a(CHEBI:"glutamate(2-)")) + p(HGNC:PSEN1) regulates p(HGNC:APP) + + + + + + + + + + + + - pmid:26472524 + pubmed:22426017 - act(p(FPLX:CHRN)) increases sec(a(CHEBI:"glutamate(2-)")) + p(HGNC:PSEN1) increases bp(GO:"neuron death") + + - pmid:17009926 + pubmed:19293145 - p(FPLX:CHRN) increases sec(a(CHEBI:"gamma-aminobutyric acid")) + p(HGNC:PSEN1) causesNoChange path(CONSO:Neurodegeneration) - pmid:17009926 + pubmed:19293145 - p(FPLX:CHRN) regulates act(complex(GO:"GABA-A receptor complex")) + p(HGNC:PSEN1) association path(MESH:"Alzheimer Disease") - pmid:17009926 + pubmed:26968346 - act(p(FPLX:CHRN)) increases bp(GO:"long term synaptic depression") + p(HGNC:PSEN1) positiveCorrelation bp(GO:"autophagosome-lysosome fusion") - pmid:17009926 + pubmed:26968346 - act(p(FPLX:CHRN)) increases bp(GO:"regulation of action potential firing rate") + p(HGNC:PSEN1) positiveCorrelation bp(GO:"endomembrane system organization") - pmid:17009926 + pubmed:26968346 - p(FPLX:CHRN) association bp(GO:"regulation of action potential firing rate") + p(HGNC:PSEN1) positiveCorrelation bp(GO:"sequestering of calcium ion") + + - pmid:17009926 + pubmed:27299292 - p(FPLX:CHRN) increases bp(GO:"regulation of action potential firing rate") + p(HGNC:PSEN1, loc(GO:"excitatory synapse")) decreases p(HGNC:TFEB) - pmid:17009926 + pubmed:27299292 - p(FPLX:CHRN) association bp(GO:"regulation of action potential firing pattern") + p(HGNC:PSEN1) increases act(p(HGNC:TFEB)) - pmid:17009926 + pubmed:27299292 - act(p(FPLX:CHRN)) negativeCorrelation path(MESH:"Lewy Body Disease") + p(HGNC:PSEN1) increases act(p(HGNC:TFEB)) - pmid:17009926 + pubmed:27299292 - p(FPLX:CHRN) negativeCorrelation path(MESH:"Lewy Body Disease") + p(HGNC:PSEN1, loc(GO:"excitatory synapse")) regulates act(a(MESH:Lysosomes)) - pmid:17009926 + pubmed:27299292 - act(p(FPLX:CHRN)) negativeCorrelation path(MESH:"Down Syndrome") + p(HGNC:PSEN1) negativeCorrelation path(DOID:"Alzheimer's disease") - pmid:17009926 + pubmed:27299292 - p(FPLX:CHRN) negativeCorrelation path(MESH:"Down Syndrome") + p(HGNC:PSEN1) increases p(HGNC:SESN2) - pmid:17009926 + pubmed:27299292 - act(p(FPLX:CHRN)) negativeCorrelation path(MESH:"Parkinson Disease") + p(HGNC:PSEN1) decreases p(HGNCGENEFAMILY:"MTOR complex 1", loc(GO:"lysosomal membrane")) - pmid:17009926 + pubmed:29758300 - p(FPLX:CHRN) negativeCorrelation path(MESH:"Parkinson Disease") + p(HGNC:PSEN1) association bp(GO:"calcium ion homeostasis") - pmid:11230871 + pubmed:29758300 - p(FPLX:CHRN) association path(MESH:"Parkinson Disease") + p(HGNC:PSEN1) association bp(GO:"regulation of lysosomal lumen pH") + + - pmid:17009926 + pubmed:22908190 - p(FPLX:CHRN) association bp(GO:"response to pain") + p(HGNC:PSEN1) increases bp(GO:"pH reduction") - pmid:17009926 + pubmed:22908190 - p(FPLX:CHRN) association path(MESH:Anxiety) + p(HGNC:PSEN1) increases act(a(MESH:Cathepsins)) - pmid:11230871 + pubmed:22908190 - p(FPLX:CHRN) association path(MESH:Anxiety) + p(HGNC:PSEN1) increases p(HGNC:ATP6V0A1, pmod(go:0006487 ! "protein N-linked glycosylation")) - pmid:17009926 + pubmed:24027553 - p(FPLX:CHRN) association path(MESH:Depression) + p(HGNC:PSEN1) increases bp(GO:"vacuolar acidification") + + - pmid:11230871 + pubmed:24107444 - p(FPLX:CHRN) association path(MESH:Depression) + complex(GO:"gamma-secretase complex") association p(HGNC:NOTCH1) - pmid:17009926 + pubmed:24107444 - act(p(FPLX:CHRN)) increases path(MESH:Arousal) + complex(GO:"gamma-secretase complex") association p(HGNC:APP) - pmid:28445721 + pubmed:28745240 - p(FPLX:CHRN) association path(MESH:Arousal) + complex(GO:"gamma-secretase complex") regulates p(CONSO:C99) - pmid:17009926 + pubmed:21861815 - act(p(FPLX:CHRN)) increases bp(GO:"circadian sleep/wake cycle, REM sleep") + complex(GO:"gamma-secretase complex") increases a(CHEBI:amyloid-beta) - pmid:26472524 + pubmed:29758300 - p(FPLX:CHRN) increases tloc(a(CHEBI:"sodium(1+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + complex(GO:"gamma-secretase complex") association a(CHEBI:amyloid-beta) - pmid:26472524 + pubmed:21861815 - p(FPLX:CHRN) increases tloc(a(CHEBI:"sodium(1+)"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) + complex(GO:"gamma-secretase complex") increases a(CONSO:"amyloid-beta aggregates") - pmid:26472524 + pubmed:29758300 - p(FPLX:CHRN) increases tloc(a(CHEBI:"potassium(1+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + complex(GO:"gamma-secretase complex") increases p(HGNC:APP, frag("?")) - pmid:26472524 + pubmed:29758300 - p(FPLX:CHRN) increases tloc(a(CHEBI:"potassium(1+)"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) + complex(GO:"gamma-secretase complex") association a(MESH:"Amyloid beta-Peptides") - pmid:26813123 + pubmed:14556719 - p(FPLX:CHRN) increases bp(GO:cognition) + complex(GO:"gamma-secretase complex") increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta polypeptide 40"), a(CHEBI:"amyloid-beta polypeptide 42"))) - pmid:25514383 + pubmed:14556719 - p(FPLX:CHRN) regulates bp(GO:cognition) + act(complex(GO:"gamma-secretase complex")) association p(HGNC:PSEN1, var("?")) - pmid:28445721 + pubmed:14556719 - p(FPLX:CHRN) association bp(GO:cognition) + act(complex(GO:"gamma-secretase complex")) association p(HGNC:PSEN2, var("?")) - pmid:28445721 + pubmed:24107444 - p(FPLX:CHRN) association bp(GO:cognition) + p(HGNC:NOTCH1) association complex(GO:"gamma-secretase complex") + + + + - pmid:28445721 + pubmed:24107444 - p(FPLX:CHRN) association bp(GO:cognition) + p(MGI:Psen1) positiveCorrelation bp(GO:"long-term synaptic potentiation") - pmid:11230871 + pubmed:24107444 - p(FPLX:CHRN) association bp(GO:cognition) + p(MGI:Psen1) positiveCorrelation bp(MESH:"Neuronal Plasticity") - pmid:26813123 + pubmed:24107444 - p(FPLX:CHRN) decreases bp(HBP:Neurodegeneration) + p(MGI:Psen1) positiveCorrelation tloc(a(CHEBI:"L-glutamic acid"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) @@ -35176,10942 +35335,11180 @@

Statements

- pmid:25514383 + pubmed:24107444 - p(FPLX:CHRN) isA a(MESH:"Cysteine Loop Ligand-Gated Ion Channel Receptors") + bp(GO:"long-term synaptic potentiation") positiveCorrelation p(MGI:Psen1) - - - - - - - - - - - - - - - - - - - + + + pubmed:24107444 + + bp(GO:"long-term synaptic potentiation") positiveCorrelation a(CHEBI:"calcium(2+)") + - pmid:25514383 + pubmed:28745240 - p(FPLX:CHRN) regulates bp(GO:"potassium ion transport") + bp(GO:"long-term synaptic potentiation") association path(MESH:"Spatial Memory") - pmid:25514383 + pubmed:28745240 - p(FPLX:CHRN) regulates bp(GO:"sodium ion transport") + bp(GO:"long-term synaptic potentiation") decreases p(HGNC:NFKB1) - pmid:25514383 + pubmed:28745240 - p(FPLX:CHRN) regulates bp(GO:"calcium ion transport") + bp(GO:"long-term synaptic potentiation") decreases p(HGNC:RELA) - pmid:25514383 + pubmed:29661268 - act(p(FPLX:CHRN)) increases bp(MESH:"Synaptic Potentials") + bp(GO:"long-term synaptic potentiation") negativeCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 274)) - pmid:25514383 + pubmed:29661268 - p(FPLX:CHRN) regulates path(MESH:"Cognition Disorders") + bp(GO:"long-term synaptic potentiation") negativeCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 281)) - pmid:28445721 + pubmed:21871088 - p(FPLX:CHRN) association path(MESH:Motivation) + bp(GO:"long-term synaptic potentiation") decreases act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) - pmid:28445721 + pubmed:21871088 - act(p(FPLX:CHRN)) increases act(a(MESH:"Dopaminergic Neurons")) + bp(GO:"long-term synaptic potentiation") association bp(GO:"calcium ion import") - pmid:28445721 + pubmed:21871088 - p(FPLX:CHRN) increases bp(GO:"positive regulation of synaptic plasticity") + bp(GO:"long-term synaptic potentiation") association bp(GO:"cellular calcium ion homeostasis") - pmid:28445721 + pubmed:19126755 - p(FPLX:CHRN) increases bp(GO:"dopamine secretion") + bp(GO:"long-term synaptic potentiation") increases bp(GO:"depolarization of postsynaptic membrane") - pmid:28445721 + pubmed:19126755 - p(FPLX:CHRN) association path(MESH:"Tobacco Use Disorder") + bp(GO:"long-term synaptic potentiation") increases bp(GO:"receptor clustering") - pmid:21482353 + pubmed:24511233 - act(p(FPLX:CHRN)) association path(MESH:"Tobacco Use Disorder") + bp(GO:"long-term synaptic potentiation") association bp(GO:learning) - pmid:21482353 + pubmed:24511233 - p(FPLX:CHRN) increases tloc(a(CHEBI:neurotransmitter), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) + bp(GO:"long-term synaptic potentiation") association bp(GO:memory) - pmid:11230871 + pubmed:21787755 - act(p(FPLX:CHRN)) regulates tloc(a(CHEBI:neurotransmitter), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) + bp(GO:"long-term synaptic potentiation") association p(CONSO:"alpha-7-containing nAChR") - pmid:21482353 + pubmed:22908190 - act(p(FPLX:CHRN)) association complex(p(FPLX:CHRN), p(HGNC:LYNX1)) + bp(GO:"long-term synaptic potentiation") negativeCorrelation act(p(HGNC:RAB5A)) - pmid:21482353 + pubmed:24760868 - surf(p(FPLX:CHRN)) association complex(p(FPLX:CHRN), p(HGNC:LYNX1)) + bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:MAPT) - pmid:21482353 + pubmed:24760868 - p(FPLX:CHRN) regulates p(HGNC:LYNX1) + bp(GO:"long-term synaptic potentiation") positiveCorrelation tloc(p(HGNC:MAPT), fromLoc(GO:"dendritic shaft"), toLoc(GO:synapse)) - pmid:21482353 + pubmed:24760868 - act(p(FPLX:CHRN)) negativeCorrelation act(a(MESH:Brain)) + bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:MAPT) - pmid:21482353 + pubmed:24760868 - act(p(FPLX:CHRN)) negativeCorrelation a(MESH:Neurons) + bp(GO:"long-term synaptic potentiation") positiveCorrelation p(MESH:Actins) - pmid:21482353 + pubmed:24760868 - p(FPLX:CHRN) regulates bp(GO:"GABAergic neuron differentiation") + bp(GO:"long-term synaptic potentiation") positiveCorrelation p(MESH:Actins) - pmid:21482353 + pubmed:24760868 - p(FPLX:CHRN) increases act(a(HP:"inhibitory interneuron")) + bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:FYN) - pmid:21482353 + pubmed:24760868 - p(FPLX:CHRN) increases act(p(FPLX:NOS)) + bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:GRIA1) - pmid:11230871 + pubmed:24760868 - p(FPLX:CHRN) association a(MESH:"Neurotransmitter Agents") + bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:GRIA1) - pmid:11230871 + pubmed:24760868 - p(FPLX:CHRN) association path(MESH:"Tourette Syndrome") + bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:DLG4) - pmid:11230871 + pubmed:24760868 - p(FPLX:CHRN) negativeCorrelation path(MESH:"Cognitive Dysfunction") + bp(GO:"long-term synaptic potentiation") decreases complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) - pmid:11230871 + pubmed:24760868 - p(FPLX:CHRN) negativeCorrelation p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) + bp(GO:"long-term synaptic potentiation") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) - pmid:11230871 + pubmed:24760868 - p(FPLX:CHRN) negativeCorrelation a(MESH:"Amyloid beta-Peptides") + bp(GO:"long-term synaptic potentiation") increases p(HGNC:MAPT, var("p.Thr205Ala"), loc(MESH:"Dendritic Spines")) - pmid:11230871 + pubmed:21882945 - p(FPLX:CHRN) negativeCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:HSPB1) - pmid:11230871 + pubmed:24107444 - p(FPLX:CHRN) negativeCorrelation bp(GO:"response to oxidative stress") + p(MGI:Ncstn) isA complex(GO:"gamma-secretase complex") - - - pmid:21787755 + pubmed:24107444 - p(FPLX:CHRN) increases bp(GO:"maintenance of synapse structure") + p(MGI:Ncstn) positiveCorrelation bp(GO:memory) - pmid:21787755 + pubmed:24107444 - p(FPLX:CHRN) increases bp(GO:"neuron projection maintenance") + p(MGI:Ncstn) negativeCorrelation path(HP:Neurodegeneration) - pmid:22020111 + pubmed:24107444 - p(HGNC:HMOX1) increases act(p(HGNC:NFE2L2)) + path(HP:Neurodegeneration) negativeCorrelation p(MGI:Ncstn) - pmid:22020111 + pubmed:29179999 - p(HGNC:HMOX1) positiveCorrelation path(MESH:"Alzheimer Disease") + path(HP:Neurodegeneration) association act(p(FPLX:NFkappaB)) - pmid:29179999 + pubmed:27491084 - a(PUBCHEM:14193399) decreases a(CHEBI:"nitric oxide") + path(HP:Neurodegeneration) association p(HGNC:ATXN3, var("?")) - pmid:29179999 + pubmed:27491084 - a(PUBCHEM:14193399) decreases p(HGNC:TNF) + path(HP:Neurodegeneration) association p(HGNC:AR, var("?")) - pmid:29179999 + pubmed:27491084 - a(PUBCHEM:14193399) decreases p(HGNC:IL1A) + path(HP:Neurodegeneration) association p(HGNC:SNCA, var("?")) - pmid:29179999 + pubmed:23528736 - a(PUBCHEM:14193399) decreases p(HGNC:PTGS2) + path(HP:Neurodegeneration) association bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:29179999 + pubmed:29221819 - a(PUBCHEM:14193399) decreases p(HGNC:NOS2) + path(HP:Neurodegeneration) positiveCorrelation p(MGI:Dyrk1a) - pmid:29179999 + pubmed:22483294 - a(PUBCHEM:14193399) decreases act(p(FPLX:NFkappaB)) + g(DBSNP:rs4680) association g(HGNC:COMT) - pmid:29179999 + pubmed:22483294 - a(PUBCHEM:14193399) decreases act(p(HGNC:MAPK14)) + g(DBSNP:rs4680) association path(MESH:"Psychotic Disorders") - pmid:29179999 + pubmed:22483294 - a(PUBCHEM:14193399) decreases a(CHEBI:"reactive oxygen species") + g(DBSNP:rs4680) regulates path(MESH:"Memory, Episodic") - pmid:29179999 + pubmed:22483294 - a(PUBCHEM:73078) decreases act(p(FPLX:NFkappaB)) + g(HGNC:COMT) association g(DBSNP:rs4680) - pmid:29179999 + pubmed:22483294 - a(PUBCHEM:73078) decreases act(p(FPLX:NFkappaB)) + path(MESH:"Psychotic Disorders") association g(DBSNP:rs4680) - pmid:29179999 + pubmed:24883238 - a(PUBCHEM:73078) decreases a(MESH:Cytokines) + path(MESH:"Psychotic Disorders") positiveCorrelation g(DBSNP:rs3764640) - pmid:29179999 + pubmed:30061532 - a(PUBCHEM:73078) decreases deg(p(HGNC:NFKBIA)) + path(MESH:"Psychotic Disorders") association path(MESH:Schizophrenia) - pmid:29179999 + pubmed:24511233 - a(PUBCHEM:73078) decreases tloc(p(HGNC:RELA), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) + path(MESH:"Psychotic Disorders") association path(MESH:Schizophrenia) - pmid:29179999 + pubmed:30061532 - a(PUBCHEM:73078) decreases act(p(HGNC:CHUK)) + path(MESH:"Psychotic Disorders") association p(HGNC:SNCA, var("?")) - pmid:29179999 + pubmed:30061532 - a(PUBCHEM:73078) decreases act(p(HGNC:IKBKB)) + path(MESH:"Psychotic Disorders") association path(MESH:"Frontotemporal Lobar Degeneration") - pmid:29179999 + pubmed:24511233 - a(PUBCHEM:73078) increases path(MESH:"Spatial Learning") + path(MESH:"Psychotic Disorders") association path(MESH:"Alzheimer Disease") - pmid:29179999 + pubmed:24511233 - a(PUBCHEM:73078) increases bp(GO:memory) + path(MESH:"Psychotic Disorders") association path(MESH:"Alzheimer Disease") - pmid:29179999 + pubmed:24511233 - a(PUBCHEM:73078) decreases p(HGNC:IL1B) + path(MESH:"Psychotic Disorders") association path(MESH:"Alzheimer Disease") - pmid:29179999 + pubmed:24590577 - a(PUBCHEM:73078) decreases p(HGNC:TNF) + path(MESH:"Psychotic Disorders") association p(HGNC:CHRM4) - pmid:27288790 + pubmed:22040696 - a(MESH:Cytokines) increases act(p(FPLX:"IKK_complex")) + path(MESH:"Psychotic Disorders") negativeCorrelation act(p(HGNC:RIC3), ma(go:0044183 ! "protein binding involved in protein folding")) - pmid:27288790 + pubmed:22483294 - a(MESH:Cytokines) increases m(MIRBASE:"hsa-mir-155") + p(HGNC:COMT) positiveCorrelation a(CHEBI:homocysteine) - pmid:29179999 + pubmed:22483294 - a(CHEBI:berberine) decreases path(MESH:Inflammation) + p(HGNC:COMT) negativeCorrelation bp(GO:"short-term memory") - pmid:29179999 + pubmed:22483294 - a(CHEBI:berberine) decreases p(HGNC:RELA, pmod(Ph)) + a(CHEBI:homocysteine) positiveCorrelation p(HGNC:COMT) - pmid:29179999 + pubmed:30962309 - a(CHEBI:berberine) decreases p(HGNC:RELA) + a(CHEBI:homocysteine) increases path(EFO:"endothelial dysfunction") - pmid:29179999 + pubmed:24524964 - a(CHEBI:berberine) decreases p(HGNC:NFKBIA, pmod(Ph)) + a(CHEBI:homocysteine) association a(NIFT:"Hippocampus volume") - pmid:29179999 + pubmed:24028866 - a(CHEBI:berberine) decreases act(p(HGNC:MAPK14)) + a(CHEBI:homocysteine) positiveCorrelation a(NIFT:"Hippocampal atrophy") - pmid:29179999 + pubmed:24653673 - a(CHEBI:berberine) decreases act(p(FPLX:ERK)) + a(CHEBI:homocysteine) negativeCorrelation p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) - pmid:29179999 + pubmed:24653673 - a(CHEBI:berberine) decreases act(p(FPLX:AKT)) + a(CHEBI:homocysteine) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:29179999 + pubmed:24653673 - a(CHEBI:oridonin) decreases act(p(FPLX:NFkappaB)) + a(CHEBI:homocysteine) positiveCorrelation p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation")) - pmid:29179999 + pubmed:28632203 - a(CHEBI:oridonin) increases bp(GO:cognition) + a(CHEBI:homocysteine) biomarkerFor path(MESH:"Alzheimer Disease") + + - pmid:29179999 + pubmed:22483294 - a(CHEBI:oridonin) decreases path(MESH:Inflammation) + bp(GO:"short-term memory") negativeCorrelation p(HGNC:COMT) - pmid:29179999 + pubmed:23091460 - a(CHEBI:Anatabine) decreases act(p(FPLX:NFkappaB)) + act(p(HGNCGENEFAMILY:"V-type ATPases")) positiveCorrelation p(HGNC:PSEN1) - pmid:22807490 + pubmed:23091460 - a(CHEBI:Anatabine) decreases act(p(FPLX:NFkappaB)) + act(p(HGNCGENEFAMILY:"V-type ATPases")) positiveCorrelation bp(GO:autophagy) - pmid:26010758 + pubmed:26968346 - a(CHEBI:Anatabine) decreases act(p(FPLX:NFkappaB)) + p(HGNCGENEFAMILY:"V-type ATPases") regulates bp(GO:"lysosomal lumen acidification") - pmid:26010758 + pubmed:26968346 - a(CHEBI:Anatabine) decreases act(p(FPLX:NFkappaB)) + p(HGNCGENEFAMILY:"V-type ATPases") regulates bp(GO:"lysosomal protein catabolic process") - pmid:26010758 + pubmed:23091460 - a(CHEBI:Anatabine) decreases act(p(FPLX:NFkappaB)) + bp(GO:autophagy) positiveCorrelation act(p(HGNCGENEFAMILY:"V-type ATPases")) - pmid:29179999 + pubmed:23091460 - a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta") + bp(GO:autophagy) positiveCorrelation p(HGNC:PSEN1) - pmid:21958873 + pubmed:22372633 - a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta") + bp(GO:autophagy) negativeCorrelation bp(GO:"stress granule assembly") - pmid:21958873 + pubmed:22372633 - a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta") + bp(GO:autophagy) association p(HGNC:HDAC6) - pmid:26010758 + pubmed:29661268 - a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta") + bp(GO:autophagy) negativeCorrelation p(HGNC:ULK1, pmod(go:0006468 ! "protein phosphorylation")) - pmid:29179999 + pubmed:29661268 - a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 40") + bp(GO:autophagy) positiveCorrelation p(HGNC:ULK1) - pmid:21958873 + pubmed:29661268 - a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 40") + bp(GO:autophagy) negativeCorrelation a(CHEBI:sirolimus) - pmid:21958873 + pubmed:26968346 - a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 40") + bp(GO:autophagy) positiveCorrelation a(CHEBI:sirolimus) - pmid:21958873 + pubmed:30061532 - a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 40") + bp(GO:autophagy) increases deg(p(MESH:Proteins, pmod(CONSO:misfolded))) - pmid:29179999 + pubmed:21722302 - a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 42") + bp(GO:autophagy) decreases p(MESH:Proteins, pmod(CONSO:misfolded)) - pmid:21958873 + pubmed:21722302 - a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 42") + bp(GO:autophagy) increases deg(p(MESH:Proteins, pmod(CONSO:misfolded))) - pmid:21958873 + pubmed:30061532 - a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 42") + bp(GO:autophagy) decreases path(MESH:"Neurodegenerative Diseases") - pmid:21958873 + pubmed:21722302 - a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 42") + bp(GO:autophagy) association path(MESH:"Neurodegenerative Diseases") - pmid:22807490 + pubmed:18930136 - a(CHEBI:Anatabine) decreases bp(GO:"inflammatory response") + bp(GO:autophagy) association path(MESH:"Neurodegenerative Diseases") - pmid:23178521 + pubmed:18930136 - a(CHEBI:Anatabine) regulates bp(GO:"inflammatory response") + bp(GO:autophagy) negativeCorrelation path(MESH:"Neurodegenerative Diseases") - pmid:26010758 + pubmed:30061532 - a(CHEBI:Anatabine) decreases bp(GO:"inflammatory response") + bp(GO:autophagy) negativeCorrelation act(p(HGNC:MTOR)) - pmid:26010758 + pubmed:30061532 - a(CHEBI:Anatabine) decreases bp(GO:"inflammatory response") + bp(GO:autophagy) regulates act(p(HGNC:MTOR)) - pmid:26010758 + pubmed:30106381 - a(CHEBI:Anatabine) decreases bp(GO:"inflammatory response") + bp(GO:autophagy) association p(HGNC:MTOR) - pmid:22807490 + pubmed:26968346 - a(CHEBI:Anatabine) decreases path(MESH:"Thyroiditis, Autoimmune") + bp(GO:autophagy) positiveCorrelation act(p(HGNC:MTOR)) - pmid:22807490 + pubmed:29758300 - a(CHEBI:Anatabine) decreases a(MESH:Thyroglobulin) + bp(GO:autophagy) negativeCorrelation p(HGNC:MTOR) - pmid:22807490 + pubmed:18930136 - a(CHEBI:Anatabine) decreases p(HGNC:IL1R2) + bp(GO:autophagy) negativeCorrelation p(HGNC:MTOR) - pmid:22807490 + pubmed:30061532 - a(CHEBI:Anatabine) decreases p(HGNC:NOS2) + bp(GO:autophagy) decreases act(a(CHEBI:methamphetamine)) - pmid:22807490 + pubmed:30061532 - a(CHEBI:Anatabine) decreases p(HGNC:PTGS2) + bp(GO:autophagy) decreases act(a(CHEBI:methamphetamine)) - pmid:22807490 + pubmed:30061532 - a(CHEBI:Anatabine) decreases bp(GO:"macrophage activation") + bp(GO:autophagy) decreases tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:21958873 + pubmed:30061532 - a(CHEBI:Anatabine) causesNoChange sec(p(HGNC:LDHA)) + bp(GO:autophagy) decreases tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:21958873 + pubmed:30061532 - a(CHEBI:Anatabine) decreases sec(p(HBP:"sAPP-beta")) + bp(GO:autophagy) association bp(GO:"dopamine secretion, neurotransmission") - pmid:21958873 + pubmed:30061532 - a(CHEBI:Anatabine) causesNoChange sec(p(HBP:"sAPP-alpha")) + bp(GO:autophagy) negativeCorrelation path(MESH:Schizophrenia) - pmid:21958873 + pubmed:30061532 - a(CHEBI:Anatabine) decreases act(complex(GO:"NF-kappaB complex")) + bp(GO:autophagy) negativeCorrelation path(MESH:Schizophrenia) - pmid:21958873 + pubmed:30061532 - a(CHEBI:Anatabine) decreases act(complex(GO:"NF-kappaB complex")) + bp(GO:autophagy) negativeCorrelation path(MESH:Schizophrenia) - pmid:21958873 + pubmed:30061532 - a(CHEBI:Anatabine) decreases act(complex(GO:"NF-kappaB complex")) + bp(GO:autophagy) association p(HGNC:BECN1) - pmid:21958873 + pubmed:26968346 - a(CHEBI:Anatabine) decreases act(complex(GO:"NF-kappaB complex")) + bp(GO:autophagy) positiveCorrelation p(HGNC:BECN1) - pmid:21958873 + pubmed:26968346 - a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph)) + bp(GO:autophagy) positiveCorrelation act(p(HGNC:BECN1)) - pmid:23178521 + pubmed:26702100 - a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph)) + bp(GO:autophagy) association p(HGNC:BECN1) - pmid:23178521 + pubmed:30061532 - a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph)) + bp(GO:autophagy) association p(HGNC:ULK2) - pmid:23178521 + pubmed:30061532 - a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph)) + bp(GO:autophagy) association p(HGNC:ATG3) - pmid:23178521 + pubmed:30061532 - a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph)) + bp(GO:autophagy) negativeCorrelation path(MESH:Hallucinations) - pmid:23178521 + pubmed:30106381 - a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph)) + bp(GO:autophagy) association p(HGNC:ADNP) - pmid:23178521 + pubmed:30106381 - a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph)) + bp(GO:autophagy) association p(HGNC:ADNP) - pmid:23178521 + pubmed:30106381 - a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph)) + bp(GO:autophagy) association a(PUBCHEM:9832404) - pmid:23178521 + pubmed:22020111 - a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(Ph)) + bp(GO:autophagy) positiveCorrelation complex(p(HGNC:BAG3), p(HGNC:HSPB8)) - pmid:21958873 + pubmed:30688256 - a(CHEBI:Anatabine) decreases r(HGNC:BACE1) + bp(GO:autophagy) increases a(MESH:"Autophagy-Related Proteins", loc(GO:"phagophore assembly site")) - pmid:26010758 + pubmed:30688256 - a(CHEBI:Anatabine) decreases r(HGNC:BACE1) + bp(GO:autophagy) association a(CHEBI:FAD) - pmid:21958873 + pubmed:30012004 - a(CHEBI:Anatabine) decreases p(HGNC:BACE1) + bp(GO:autophagy) positiveCorrelation path(MESH:"Huntington Disease") - pmid:21958873 + pubmed:30027901 - a(CHEBI:Anatabine) decreases p(HGNC:CRP) + bp(GO:autophagy) association act(p(HGNC:HTT)) - pmid:23178521 + pubmed:30027901 - a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph)) + bp(GO:autophagy) association p(HGNC:HTT) - pmid:23178521 + pubmed:26968346 - a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph)) + bp(GO:autophagy) increases deg(p(HGNC:HTT)) - pmid:23178521 + pubmed:30027901 - a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph)) + bp(GO:autophagy) decreases a(MESH:"Protein Aggregates") - pmid:23178521 + pubmed:30027901 - a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph)) + bp(GO:autophagy) increases tloc(a(MESH:"Protein Aggregates"), fromLoc(GO:cytoplasm), toLoc(GO:lysosome)) - pmid:23178521 + pubmed:23746257 - a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph)) + bp(GO:autophagy) decreases a(MESH:"Protein Aggregates") - pmid:23178521 + pubmed:21722302 - a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph)) + bp(GO:autophagy) increases bp(MESH:Neuroprotection) - pmid:23178521 + pubmed:21722302 - a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph)) + bp(GO:autophagy) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:23178521 + pubmed:29758300 - a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph)) + bp(GO:autophagy) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:26010758 + pubmed:22908190 - a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(Ph)) + bp(GO:autophagy) association path(MESH:"Alzheimer Disease") - pmid:23178521 + pubmed:22908190 - a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph)) + bp(GO:autophagy) association path(MESH:"Alzheimer Disease") - pmid:23178521 + pubmed:26968346 - a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph)) + bp(GO:autophagy) positiveCorrelation a(CHEBI:Temsirolimus) - pmid:23383175 + pubmed:26968346 - a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph)) + bp(GO:autophagy) positiveCorrelation bp(GO:"regulation of ER to Golgi vesicle-mediated transport") - pmid:23383175 + pubmed:26968346 - a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph)) + bp(GO:autophagy) negativeCorrelation p(CONSO:"alpha-synuclein aggregates") - pmid:23383175 + pubmed:26968346 - a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph)) + bp(GO:autophagy) positiveCorrelation p(HGNC:RAB1A) - pmid:23383175 + pubmed:27299292 - a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph)) + bp(GO:autophagy) positiveCorrelation act(p(HGNC:TFEB)) - pmid:23383175 + pubmed:27299292 - a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(Ph)) + bp(GO:autophagy) positiveCorrelation p(HGNC:TFEB) - pmid:23178521 + pubmed:27299292 - a(CHEBI:Anatabine) decreases p(MGI:Tnf) + bp(GO:autophagy) positiveCorrelation p(HGNC:AR, pmod(CONSO:"CAG repeats")) - pmid:23383175 + pubmed:27299292 - a(CHEBI:Anatabine) causesNoChange p(MGI:Tnf) + bp(GO:autophagy) negativeCorrelation p(HGNC:AR, pmod(CONSO:"CAG repeats")) - pmid:23383175 + pubmed:27299292 - a(CHEBI:Anatabine) decreases p(MGI:Tnf) + bp(GO:autophagy) negativeCorrelation p(HGNC:AR, pmod(CONSO:"CAG repeats")) - pmid:23178521 + pubmed:27299292 - a(CHEBI:Anatabine) decreases p(MGI:Il6) + bp(GO:autophagy) increases path(DOID:"pancreatic ductal adenocarcinoma") - pmid:23383175 + pubmed:27299292 - a(CHEBI:Anatabine) decreases p(MGI:Il6) + bp(GO:autophagy) negativeCorrelation path(MESH:"Protein Aggregation, Pathological") - pmid:23383175 + pubmed:27299292 - a(CHEBI:Anatabine) decreases a(MESH:Cytokines) + bp(GO:autophagy) negativeCorrelation path(DOID:"spinal muscular atrophy") - pmid:23383175 + pubmed:27299292 - a(CHEBI:Anatabine) negativeCorrelation path(MESH:Encephalomyelitis) + bp(GO:autophagy) increases deg(p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) - pmid:23383175 + pubmed:24844691 - a(CHEBI:Anatabine) decreases path(MESH:Encephalomyelitis) + bp(GO:autophagy) increases deg(p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) - pmid:23383175 + pubmed:27299292 - a(CHEBI:Anatabine) decreases path(MESH:Paralysis) + bp(GO:autophagy) increases deg(p(HGNC:MAPT, pmod(CONSO:misfolded))) - DOI:10.4172/2168-975X.1000126 + pubmed:29758300 - a(CHEBI:Anatabine) decreases path(MESH:Paralysis) + bp(GO:autophagy) positiveCorrelation bp(GO:"lysosomal protein catabolic process") - pmid:23383175 + pubmed:22908190 - a(CHEBI:Anatabine) decreases path(HP:"Limb muscle weakness") + bp(GO:autophagy) positiveCorrelation bp(GO:"lysosomal protein catabolic process") - pmid:23383175 + pubmed:29758300 - a(CHEBI:Anatabine) decreases p(MGI:Il1b) + bp(GO:autophagy) decreases a(CHEBI:amyloid-beta) - pmid:23383175 + pubmed:22908190 - a(CHEBI:Anatabine) decreases p(MGI:Il1b) + bp(GO:autophagy) increases deg(a(CHEBI:amyloid-beta)) - pmid:23383175 + pubmed:24844691 - a(CHEBI:Anatabine) decreases p(MGI:Il17a) + bp(GO:autophagy) increases deg(a(CHEBI:amyloid-beta)) - pmid:23383175 + pubmed:29758300 - a(CHEBI:Anatabine) decreases p(MGI:Il17a) + bp(GO:autophagy) increases deg(p(MESH:Proteins, pmod(CONSO:misfolding))) - pmid:23383175 + pubmed:18930136 - a(CHEBI:Anatabine) causesNoChange p(MGI:Ifng) + bp(GO:autophagy) regulates deg(p(MESH:Proteins, pmod(CONSO:misfolding))) - pmid:23383175 + pubmed:29758300 - a(CHEBI:Anatabine) decreases p(MGI:Ifng) + bp(GO:autophagy) increases deg(a(CONSO:"protein aggregates")) - pmid:23383175 + pubmed:22908190 - a(CHEBI:Anatabine) decreases p(MGI:Rela, pmod(Ph)) + bp(GO:autophagy) increases deg(a(CONSO:"protein aggregates")) - pmid:23383175 + pubmed:22908190 - a(CHEBI:Anatabine) decreases p(MGI:Rela, pmod(Ph)) + bp(GO:autophagy) increases deg(a(CONSO:"protein aggregates")) - pmid:23383175 + pubmed:22908190 - a(CHEBI:Anatabine) causesNoChange bp(HBP:Astrogliosis) + bp(GO:autophagy) increases deg(a(CONSO:"protein aggregates")) - pmid:23383175 + pubmed:29758300 - a(CHEBI:Anatabine) decreases bp(HBP:Astrogliosis) + bp(GO:autophagy) association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:23383175 + pubmed:29758300 - a(CHEBI:Anatabine) decreases bp(HBP:Microgliosis) + bp(GO:autophagy) increases deg(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) - DOI:10.4172/2168-975X.1000126 + pubmed:29626319 - a(CHEBI:Anatabine) decreases bp(HBP:Microgliosis) + bp(GO:autophagy) increases deg(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) - pmid:23383175 + pubmed:29758300 - a(CHEBI:Anatabine) decreases tloc(a(MESH:Leukocytes), fromLoc(GO:"extracellular region"), toLoc(MESH:"Spinal Cord")) + bp(GO:autophagy) association p(HGNC:MAPT, frag("?")) - pmid:23383175 + pubmed:29758300 - a(CHEBI:Anatabine) decreases a(MESH:Microglia) + bp(GO:autophagy) association a(CONSO:"Tau aggregates") - pmid:23383175 + pubmed:29758300 - a(CHEBI:Anatabine) decreases tloc(a(MESH:Microglia), fromLoc(GO:"extracellular region"), toLoc(MESH:"Spinal Cord")) + bp(GO:autophagy) increases deg(p(HGNC:SNCA)) - pmid:23383175 + pubmed:18930136 - a(CHEBI:Anatabine) decreases tloc(a(MESH:Macrophages), fromLoc(GO:"extracellular region"), toLoc(MESH:"Spinal Cord")) + bp(GO:autophagy) increases deg(p(HGNC:SNCA)) - pmid:23383175 + pubmed:30985105 - a(CHEBI:Anatabine) positiveCorrelation a(GO:"myelin sheath") + bp(GO:autophagy) increases act(p(HGNC:SNCA)) - DOI:10.4172/2168-975X.1000126 + pubmed:30985105 - a(CHEBI:Anatabine) increases bp(GO:"motor behavior") + bp(GO:autophagy) decreases p(HGNC:SNCA) - DOI:10.4172/2168-975X.1000126 + pubmed:29758300 - a(CHEBI:Anatabine) increases bp(GO:"motor behavior") + bp(GO:autophagy) decreases a(CHEBI:lipid) - DOI:10.4172/2168-975X.1000126 + pubmed:29758300 - a(CHEBI:Anatabine) decreases path(MESH:Anxiety) + bp(GO:autophagy) increases deg(a(CHEBI:lipid)) - pmid:26010758 + pubmed:29758300 - a(CHEBI:Anatabine) increases path(MESH:Anxiety) + bp(GO:autophagy) negativeCorrelation a(CHEBI:lipid) - DOI:10.4172/2168-975X.1000126 + pubmed:29758300 - a(CHEBI:Anatabine) increases path(MESH:"Spatial Learning") + bp(GO:autophagy) increases deg(a(CHEBI:carbohydrate)) - DOI:10.4172/2168-975X.1000126 + pubmed:29758300 - a(CHEBI:Anatabine) causesNoChange p(HGNC:MAPT) + bp(GO:autophagy) increases deg(p(HGNC:MAPT)) - DOI:10.4172/2168-975X.1000126 + pubmed:30145931 - a(CHEBI:Anatabine) decreases p(HGNC:MAPT, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) + bp(GO:autophagy) decreases p(HGNC:MAPT) - DOI:10.4172/2168-975X.1000126 + pubmed:24027553 - a(CHEBI:Anatabine) decreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) + bp(GO:autophagy) increases deg(p(HGNC:MAPT)) - DOI:10.4172/2168-975X.1000126 + pubmed:23528736 - a(CHEBI:Anatabine) decreases p(HGNC:MAPT, pmod(Ph, Thr, 231)) + bp(GO:autophagy) increases deg(p(HGNC:MAPT)) - DOI:10.4172/2168-975X.1000126 + pubmed:25374103 - a(CHEBI:Anatabine) decreases a(GO:"neurofibrillary tangle") + bp(GO:autophagy) increases deg(p(HGNC:MAPT)) - DOI:10.4172/2168-975X.1000126 + pubmed:29626319 - a(CHEBI:Anatabine) decreases a(HBP:"Tau oligomers") + bp(GO:autophagy) increases deg(p(HGNC:MAPT)) - DOI:10.4172/2168-975X.1000126 + pubmed:29626319 - a(CHEBI:Anatabine) decreases a(HBP:"Tau oligomers") + bp(GO:autophagy) increases deg(p(HGNC:MAPT)) - DOI:10.4172/2168-975X.1000126 + pubmed:22908190 - a(CHEBI:Anatabine) increases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) + bp(GO:autophagy) increases deg(a(GO:organelle)) - DOI:10.4172/2168-975X.1000126 + pubmed:22908190 - a(CHEBI:Anatabine) increases p(FPLX:AKT, pmod(Ph, Ser, 473)) + bp(GO:autophagy) increases deg(a(GO:organelle)) - pmid:26010758 + pubmed:22908190 - a(CHEBI:Anatabine) decreases path(MESH:Gliosis) + bp(GO:autophagy) increases deg(a(GO:organelle)) - pmid:26010758 + pubmed:18930136 - a(CHEBI:Anatabine) decreases p(HGNC:MAPT, pmod(Ph)) + bp(GO:autophagy) increases tloc(a(GO:organelle), fromLoc(GO:cytoplasm), toLoc(GO:lysosome)) - pmid:26010758 + pubmed:18930136 - a(CHEBI:Anatabine) increases act(p(HGNC:CHRNA7)) + bp(GO:autophagy) increases deg(a(GO:organelle)) - pmid:26010758 + pubmed:18930136 - a(CHEBI:Anatabine) decreases act(p(HGNC:STAT3)) + bp(GO:autophagy) increases deg(a(GO:organelle)) - pmid:26010758 + pubmed:22908190 - a(CHEBI:Anatabine) decreases act(p(HGNC:STAT3)) + bp(GO:autophagy) increases deg(a(MESH:"Inclusion Bodies")) - pmid:26010758 + pubmed:22908190 - a(CHEBI:Anatabine) decreases act(p(HGNC:STAT3)) + bp(GO:autophagy) negativeCorrelation bp(GO:"proteasomal protein catabolic process") - pmid:26010758 + pubmed:22908190 - a(CHEBI:Anatabine) decreases bp(GO:locomotion) + bp(GO:autophagy) increases deg(p(CONSO:"protein aggregates", pmod(go:0016567 ! "protein ubiquitination"))) - pmid:26010758 + pubmed:22908190 - a(CHEBI:Anatabine) increases path(MESH:"Interpersonal Relations") + bp(GO:autophagy) increases rxn(reactants(p(HGNC:APP)), products(a(MESH:"Amyloid beta-Peptides"))) - pmid:26010758 + pubmed:22908190 - a(CHEBI:Anatabine) decreases p(HGNC:AIF1) + bp(GO:autophagy) decreases path(MESH:Tauopathies) - pmid:26010758 + pubmed:22908190 - a(CHEBI:Anatabine) decreases bp(GO:"microglial cell activation") + bp(GO:autophagy) decreases path(CONSO:neurotoxicity) - pmid:26010758 + pubmed:22908190 - a(CHEBI:Anatabine) decreases p(HGNC:PTPRC) + bp(GO:autophagy) increases path(CONSO:neurotoxicity) - pmid:26010758 + pubmed:30145931 - a(CHEBI:Anatabine) decreases p(FPLX:NFkappaB, pmod(Ph, Ser, 536)) + bp(GO:autophagy) decreases path(CONSO:neurotoxicity) - pmid:26010758 + pubmed:22908190 - a(CHEBI:Anatabine) decreases r(HGNC:PTGS2) + bp(GO:autophagy) association bp(GO:"regulation of synaptic plasticity") - pmid:26010758 + pubmed:23746257 - a(CHEBI:Anatabine) decreases r(HGNC:NOS2) + bp(GO:autophagy) increases bp(GO:"protein catabolic process") - pmid:25514383 + pubmed:26195256 - a(CHEBI:"amyloid-beta polypeptide 40") decreases act(a(HBP:"alpha-4 beta-2 nAChR")) + bp(GO:autophagy) increases bp(GO:"protein catabolic process") - pmid:25514383 + pubmed:18930136 - a(CHEBI:"amyloid-beta polypeptide 40") decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + bp(GO:autophagy) increases bp(GO:"cellular protein catabolic process") - pmid:14556719 + pubmed:18930136 - a(CHEBI:"amyloid-beta polypeptide 40") increases a(HBP:"amyloid-beta fibrils") + bp(GO:autophagy) regulates bp(GO:"amino acid homeostasis") - pmid:26195256 + pubmed:18930136 - a(CHEBI:"amyloid-beta polypeptide 40") isA a(CHEBI:"amyloid-beta") + bp(GO:autophagy) increases tloc(a(MESH:Proteins), fromLoc(GO:cytoplasm), toLoc(GO:lysosome)) - pmid:29179999 + pubmed:18930136 - a(CHEBI:"vitamin D") decreases p(FPLX:NFkappaB, pmod(Ph)) + bp(GO:autophagy) increases deg(a(MESH:Proteins)) - pmid:29179999 + pubmed:18930136 - a(CHEBI:"vitamin D") decreases a(CHEBI:"reactive oxygen species") + bp(GO:autophagy) regulates bp(GO:"metabolic process") - pmid:29179999 + pubmed:18930136 - a(CHEBI:"vitamin D") decreases path(MESH:Inflammation) + bp(GO:autophagy) association bp(GO:"antigen processing and presentation") - pmid:29179999 + pubmed:18930136 - a(CHEBI:"alpha-tocopherol") decreases a(CHEBI:"reactive oxygen species") + bp(GO:autophagy) decreases bp(MESH:Microbiota) - pmid:29179999 + pubmed:18930136 - a(CHEBI:"alpha-tocopherol") decreases a(CHEBI:"amyloid-beta") + bp(GO:autophagy) regulates bp(GO:"cell death") - pmid:29179999 + pubmed:18930136 - a(CHEBI:"alpha-tocopherol") decreases a(CHEBI:"amyloid-beta") + bp(GO:autophagy) increases deg(p(HGNC:SNCA, var("?"))) - pmid:29179999 + pubmed:18930136 - a(CHEBI:"alpha-tocopherol") decreases a(MESH:Cytokines) + bp(GO:autophagy) increases deg(a(CONSO:"alpha-synuclein aggregates")) - pmid:29179999 + pubmed:18930136 - a(CHEBI:"alpha-tocopherol") decreases a(CHEBI:"nitric oxide") + bp(GO:autophagy) increases deg(a(CONSO:"alpha-synuclein oligomers")) - pmid:29179999 + pubmed:18930136 - a(CHEBI:"alpha-tocopherol") increases bp(GO:memory) + bp(GO:autophagy) regulates bp(GO:"neuron cellular homeostasis") - pmid:29179999 + pubmed:18930136 - a(CHEBI:"alpha-tocopherol") decreases path(MESH:"Oxidative Stress") + bp(GO:autophagy) decreases path(CONSO:Neurodegeneration) - pmid:29179999 + pubmed:18930136 - a(CHEBI:"alpha-tocopherol") decreases act(p(FPLX:NFkappaB)) + bp(GO:autophagy) decreases path(CONSO:Neurodegeneration) - pmid:29179999 + pubmed:18930136 - a(CHEBI:"alpha-tocopherol") decreases p(HGNC:NOS2) + bp(GO:autophagy) negativeCorrelation path(MESH:"Bulbo-Spinal Atrophy, X-Linked") - pmid:29179999 + pubmed:18930136 - a(CHEBI:"alpha-tocopherol") decreases p(HGNC:IL6) + bp(GO:autophagy) increases deg(p(HGNC:APP)) - pmid:29179999 + pubmed:18930136 - a(CHEBI:"alpha-tocopherol") decreases p(HGNC:IL1B) + bp(GO:autophagy) negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:29179999 + pubmed:18930136 - a(CHEBI:"alpha-tocopherol") decreases bp(GO:"microglial cell activation") + bp(GO:autophagy) negativeCorrelation act(complex(GO:"proteasome complex")) - pmid:21718217 + pubmed:28803412 - bp(GO:"microglial cell activation") association a(HBP:HBP00089) + bp(GO:autophagy) increases a(CONSO:CONSO00093) - pmid:21718217 + pubmed:30145931 - bp(GO:"microglial cell activation") positiveCorrelation a(HBP:HBP00089) + bp(GO:autophagy) increases deg(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262), pmod(go:0006468 ! "protein phosphorylation", Ser, 356))) - pmid:26010758 + pubmed:30116051 - bp(GO:"microglial cell activation") positiveCorrelation p(HGNC:AIF1) + bp(GO:autophagy) negativeCorrelation g(HGNC:PSEN1, var("?")) - pmid:28877763 + pubmed:30116051 - bp(GO:"microglial cell activation") positiveCorrelation act(p(MGI:Syk)) + bp(GO:autophagy) increases deg(p(HGNC:HTT, var("?"))) - pmid:28877763 + pubmed:27181519 - bp(GO:"microglial cell activation") positiveCorrelation p(MGI:Syk, pmod(Ph)) + bp(GO:autophagy) increases deg(p(HGNC:HTT, var("?"))) - pmid:27314526 + pubmed:23528736 - bp(GO:"microglial cell activation") increases sec(p(HGNC:IL1B)) + bp(GO:autophagy) negativeCorrelation a(CHEBI:"reactive oxygen species") - pmid:27314526 + pubmed:27181519 - bp(GO:"microglial cell activation") increases sec(p(HGNC:IL6)) + bp(GO:autophagy) increases deg(complex(GO:"ribonucleoprotein granule")) - pmid:27314526 + pubmed:27181519 - bp(GO:"microglial cell activation") increases sec(p(HGNC:IL18)) + bp(GO:autophagy) association p(HGNC:SOD1, var("?")) - pmid:27314526 + pubmed:27181519 - bp(GO:"microglial cell activation") increases sec(p(HGNC:NOS2)) + bp(GO:autophagy) isA bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") - pmid:29179999 + pubmed:27181519 - a(PUBCHEM:444795) decreases path(MESH:Inflammation) + bp(GO:autophagy) association a(CHEBI:"all-trans-retinoic acid") - pmid:29179999 + pubmed:27181519 - a(PUBCHEM:444795) decreases p(HGNC:IL6) + bp(GO:autophagy) negativeCorrelation path(MESH:"Motor Neuron Disease") - pmid:29179999 + pubmed:27181519 - a(PUBCHEM:444795) decreases p(HGNC:IL12B) + bp(GO:autophagy) negativeCorrelation path(DOID:"amyotrophic lateral sclerosis") - pmid:29179999 + pubmed:27181519 - a(PUBCHEM:444795) decreases p(HGNC:TNF) + bp(GO:autophagy) negativeCorrelation path(DOID:"amyotrophic lateral sclerosis") - pmid:29179999 + pubmed:27181519 - a(PUBCHEM:444795) decreases act(p(FPLX:NFkappaB)) + bp(GO:autophagy) negativeCorrelation p(HGNC:FUS, var("?")) - pmid:29179999 + pubmed:27181519 - a(PUBCHEM:444795) decreases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) + bp(GO:autophagy) negativeCorrelation p(HGNC:TARDBP, var("?")) - pmid:29179999 + pubmed:27181519 - a(PUBCHEM:444795) decreases p(HGNC:BACE1) + bp(GO:autophagy) increases deg(p(HGNC:TARDBP, pmod(GO:"protein complex oligomerization"))) - pmid:29179999 + pubmed:27181519 - a(PUBCHEM:3086007) decreases a(CHEBI:"amyloid-beta") + bp(GO:autophagy) increases deg(p(HGNC:TARDBP, pmod(CONSO:"protein aggregation"))) - pmid:29179999 + pubmed:27181519 - a(PUBCHEM:441921) decreases a(CHEBI:"amyloid-beta") + bp(GO:autophagy) increases deg(p(HGNC:TARDBP, pmod(CONSO:"protein aggregation"))) - pmid:29179999 + pubmed:27181519 - a(PUBCHEM:9918693) decreases a(CHEBI:"amyloid-beta") + bp(GO:autophagy) increases deg(p(HGNC:FUS, pmod(CONSO:"protein aggregation"))) - pmid:29179999 + pubmed:27181519 - a(PUBCHEM:441923) decreases a(CHEBI:"amyloid-beta") + bp(GO:autophagy) association complex(p(HGNC:MAP1LC3A), p(HGNC:OPTN)) - pmid:29179999 + pubmed:27181519 - a(PUBCHEM:441923) decreases r(HGNC:TLR3) + bp(GO:autophagy) association a(CHEBI:"alpha,alpha-trehalose") - pmid:29179999 + pubmed:27181519 - a(PUBCHEM:441923) decreases p(HGNC:TLR3) + bp(GO:autophagy) association a(CHEBI:"lithium(1+)") - pmid:29179999 + pubmed:27181519 - a(PUBCHEM:441923) decreases r(HGNC:TLR4) + bp(GO:autophagy) association a(CHEBI:"withaferin A") - pmid:29179999 + pubmed:26702100 - a(PUBCHEM:441923) decreases p(HGNC:TLR4) + bp(GO:autophagy) association path(MESH:"Amyotrophic Lateral Sclerosis") - pmid:29179999 + pubmed:26702100 - a(PUBCHEM:441923) decreases p(FPLX:NFkappaB) + bp(GO:autophagy) association p(HGNC:ATG5) - pmid:29179999 + pubmed:26702100 - a(PUBCHEM:441923) decreases r(HGNC:TRAF6) + bp(GO:autophagy) association p(HGNC:ATG9B) - pmid:29179999 + pubmed:23702978 - a(PUBCHEM:441923) decreases p(HGNC:TRAF6) + bp(GO:autophagy) regulates bp(GO:"apoptotic process") - pmid:29179999 + pubmed:23702978 - a(PUBCHEM:441923) decreases p(HGNC:TNF) + bp(GO:autophagy) regulates complex(GO:"inflammasome complex") - pmid:29179999 + pubmed:23702978 - a(PUBCHEM:441923) decreases p(HGNC:IFNB1) + bp(GO:autophagy) decreases act(complex(GO:"inflammasome complex")) - pmid:29179999 + pubmed:23702978 - a(PUBCHEM:24721561) decreases bp(GO:"neuron death") + bp(GO:autophagy) decreases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:29179999 + pubmed:17361039 - a(PUBCHEM:24721561) increases bp(GO:learning) + r(HGNC:SLC1A3) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:29179999 + pubmed:17361039 - a(PUBCHEM:24721561) increases bp(GO:memory) + r(HGNC:SLC1A2) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:29179999 + pubmed:17361039 - a(PUBCHEM:24721561) decreases act(p(FPLX:NFkappaB)) + p(HGNC:SLC1A2) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:26631930 + pubmed:17361039 - p(HGNC:TRAF6) increases p(HGNC:MAPT, pmod(UbK63)) + p(HGNC:SLC1A2) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:29179999 + pubmed:17361039 - a(PUBCHEM:164676) decreases act(p(HGNC:NOS2)) + r(HGNC:GRIK4) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:29179999 + pubmed:17361039 - a(PUBCHEM:164676) decreases act(p(HGNC:MMP2)) + p(HGNC:POLR2M) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:29179999 + pubmed:17361039 - a(PUBCHEM:164676) decreases act(p(HGNC:RELA)) + p(HGNC:GRIA4) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:29179999 + pubmed:24883238 - a(PUBCHEM:164676) decreases path(MESH:"Alzheimer Disease") + g(DBSNP:rs3764640) positiveCorrelation path(MESH:"Psychotic Disorders") - pmid:29179999 + pubmed:24883238 - a(PUBCHEM:164676) decreases bp(GO:"apoptotic process") + g(DBSNP:rs3764640) association p(HGNC:STK11) - pmid:29179999 + pubmed:22005930 - a(PUBCHEM:164676) decreases path(MESH:Inflammation) + g(DBSNP:rs3764640) association g(HGNC:STK11) - pmid:29179999 + pubmed:24883238 - a(PUBCHEM:164676) decreases bp(GO:"neuron death") + p(HGNC:STK11) association g(DBSNP:rs3764640) - pmid:29179999 + pubmed:24883238 - a(PUBCHEM:164676) decreases p(HGNC:GFAP) + p(HGNC:STK11) negativeCorrelation path(MESH:"Peutz-Jeghers Syndrome") - pmid:29179999 + pubmed:24883238 - a(PUBCHEM:164676) decreases p(FPLX:NFkappaB) + p(HGNC:STK11) negativeCorrelation path(MESH:"Intellectual Disability") - pmid:29179999 + pubmed:24883238 - a(PUBCHEM:164676) increases p(HGNC:RBFOX3) + p(HGNC:STK11) negativeCorrelation path(MESH:Schizophrenia) - pmid:29179999 + pubmed:24883238 - a(PUBCHEM:164676) increases a(MESH:"Nissl Bodies") + p(HGNC:STK11) association p(HGNC:APP) - pmid:29179999 + pubmed:24883238 - a(PUBCHEM:164676) increases p(FPLX:IKB) + p(HGNC:STK11) association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:27594586 + pubmed:17950019 - act(p(HGNC:MMP2)) increases bp(GO:"neuron death") + p(HGNC:STK11) association p(HGNC:CRTC2) - pmid:27594586 + pubmed:17950019 - p(HGNC:MMP2) increases bp(GO:"neuron death") + p(HGNC:STK11) positiveCorrelation path(MESH:"Diabetes Mellitus, Type 2") - pmid:26195256 + pubmed:23791179 - p(HGNC:MMP2) increases deg(a(CHEBI:"amyloid-beta", loc(GO:"extracellular region"))) + p(HGNC:STK11) positiveCorrelation bp(GO:"collateral sprouting") - pmid:29626319 + pubmed:27462580 - act(p(HGNC:MMP2)) increases deg(a(CHEBI:"amyloid-beta")) + p(HGNC:STK11) regulates bp(GO:"glucose import") - pmid:26195256 + pubmed:27462580 - p(HGNC:MMP2) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:STK11) increases a(MESH:"AMP-Activated Protein Kinases") - pmid:26195256 + pubmed:16530014 - act(p(HGNC:MMP2)) negativeCorrelation path(MESH:"Plaque, Amyloid") + p(HGNC:STK11) negativeCorrelation tloc(a(CHEBI:glucose), fromLoc(MESH:Liver), toLoc(MESH:Blood)) - pmid:25652642 + pubmed:16530014 - p(HGNC:GFAP) positiveCorrelation m(HGNC:MIR125B1) + p(HGNC:STK11) negativeCorrelation a(CHEBI:glucose) - - - pmid:27288790 + pubmed:16530014 - deg(p(FPLX:IKB)) increases act(p(FPLX:NFkappaB)) + p(HGNC:STK11) negativeCorrelation path(MESH:Hyperglycemia) - + + + pubmed:16530014 + + p(HGNC:STK11) decreases act(a(CHEBI:metformin)) + - pmid:29179999 + pubmed:24883238 - a(CHEBI:"(+)-artemisinin") decreases path(MESH:Inflammation) + path(MESH:"Peutz-Jeghers Syndrome") negativeCorrelation p(HGNC:STK11) - pmid:29179999 + pubmed:24883238 - a(CHEBI:"(+)-artemisinin") decreases act(p(FPLX:NFkappaB)) + path(MESH:"Intellectual Disability") negativeCorrelation p(HGNC:STK11) - pmid:29179999 + pubmed:27190210 - a(CHEBI:"(+)-artemisinin") decreases a(CHEBI:"amyloid-beta") + path(MESH:"Intellectual Disability") association g(HGNC:CHRNA7) - pmid:29179999 + pubmed:24883238 - a(CHEBI:"(+)-artemisinin") decreases bp(GO:"NLRP3 inflammasome complex assembly") + path(MESH:Schizophrenia) negativeCorrelation p(HGNC:STK11) - pmid:28019679 + pubmed:22005930 - a(CHEBI:"(+)-artemisinin") decreases p(MGI:Nfkbia) + path(MESH:Schizophrenia) negativeCorrelation g(HGNC:STK11) - pmid:28019679 + pubmed:30061532 - a(CHEBI:"(+)-artemisinin") decreases complex(GO:"NLRP3 inflammasome complex") + path(MESH:Schizophrenia) increases path(MESH:Hallucinations) - pmid:29179999 + pubmed:24511233 - a(PUBCHEM:440312) decreases a(CHEBI:"nitric oxide") + path(MESH:Schizophrenia) association path(MESH:Hallucinations) - pmid:29179999 + pubmed:19721446 - a(PUBCHEM:440312) decreases p(HGNC:TNF) + path(MESH:Schizophrenia) association path(MESH:Hallucinations) - pmid:29179999 + pubmed:30061532 - a(PUBCHEM:440312) decreases a(CHEBI:"prostaglandin E2") + path(MESH:Schizophrenia) increases path(MESH:Delusions) - pmid:29179999 + pubmed:24511233 - a(PUBCHEM:440312) decreases p(HGNC:NOS2) + path(MESH:Schizophrenia) association path(MESH:Delusions) - pmid:29179999 + pubmed:19721446 - a(PUBCHEM:440312) decreases p(HGNC:PTGS2) + path(MESH:Schizophrenia) association path(MESH:Delusions) - pmid:29179999 + pubmed:30061532 - a(PUBCHEM:440312) decreases act(p(HGNC:LOX)) + path(MESH:Schizophrenia) positiveCorrelation act(p(HGNC:DRD1)) - pmid:29179999 + pubmed:30061532 - a(PUBCHEM:440312) decreases a(CHEBI:"reactive oxygen species") + path(MESH:Schizophrenia) association g(HGNC:DISC1) - pmid:29179999 + pubmed:30061532 - a(PUBCHEM:440312) decreases act(p(FPLX:ERK)) + path(MESH:Schizophrenia) association g(HGNC:DISC1) - pmid:29179999 + pubmed:30061532 - a(PUBCHEM:440312) decreases act(p(HGNC:MAPK14)) + path(MESH:Schizophrenia) association g(HGNC:NRG1) - pmid:29179999 + pubmed:30061532 - a(PUBCHEM:440312) decreases act(p(FPLX:NFkappaB)) + path(MESH:Schizophrenia) association g(HGNC:DPYSL2) - pmid:29179999 + pubmed:30061532 - a(CHEBI:Geniposide) decreases act(p(FPLX:ERK)) + path(MESH:Schizophrenia) association g(HGNC:DPYSL2) - pmid:29179999 + pubmed:30061532 - a(CHEBI:Geniposide) decreases act(p(FPLX:IKB)) + path(MESH:Schizophrenia) association path(MESH:"Psychotic Disorders") - pmid:29179999 + pubmed:24511233 - a(CHEBI:Geniposide) decreases act(p(FPLX:NFkappaB)) + path(MESH:Schizophrenia) association path(MESH:"Psychotic Disorders") - pmid:29179999 + pubmed:30061532 - a(CHEBI:Geniposide) decreases p(HGNC:TNF) + path(MESH:Schizophrenia) positiveCorrelation a(CHEBI:dopamine) - pmid:29179999 + pubmed:30061532 - a(CHEBI:Geniposide) decreases p(HGNC:IL1B) + path(MESH:Schizophrenia) association tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:29179999 + pubmed:30061532 - a(CHEBI:Geniposide) decreases a(CHEBI:"amyloid-beta") + path(MESH:Schizophrenia) increases a(CHEBI:dopamine) - pmid:29179999 + pubmed:30061532 - a(PUBCHEM:102336202) increases path(MESH:"Spatial Memory") + path(MESH:Schizophrenia) increases tloc(a(CHEBI:dopamine), fromLoc(MESH:"Nerve Endings"), toLoc(MESH:"Limbic System")) - pmid:29179999 + pubmed:30061532 - a(PUBCHEM:102336202) decreases path(MESH:"Oxidative Stress") + path(MESH:Schizophrenia) decreases p(HGNC:SLC6A3) - pmid:29179999 + pubmed:30061532 - a(PUBCHEM:102336202) decreases p(HGNC:NOS2) + path(MESH:Schizophrenia) negativeCorrelation p(HGNC:SLC18A2) - pmid:29179999 + pubmed:30061532 - a(PUBCHEM:102336202) decreases a(CHEBI:nitrotyrosine) + path(MESH:Schizophrenia) association a(CHEBI:"reactive oxygen species") - pmid:29179999 + pubmed:30061532 - a(PUBCHEM:102336202) increases r(HGNC:IL4) + path(MESH:Schizophrenia) negativeCorrelation bp(GO:"cytoskeleton organization") - pmid:29179999 + pubmed:30061532 - a(PUBCHEM:102336202) decreases a(MESH:Cytokines) + path(MESH:Schizophrenia) negativeCorrelation bp(GO:"neuron-neuron synaptic transmission") - pmid:29179999 + pubmed:30061532 - a(PUBCHEM:102336202) decreases a(CHEBI:"nitric oxide") + path(MESH:Schizophrenia) decreases p(HGNC:MAP2) - pmid:29179999 + pubmed:30061532 - a(PUBCHEM:102336202) decreases p(HGNC:IL1B) + path(MESH:Schizophrenia) decreases a(GO:dendrite) - pmid:29179999 + pubmed:30061532 - a(PUBCHEM:102336202) decreases p(HGNC:TNF) + path(MESH:Schizophrenia) positiveCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:29179999 + pubmed:30061532 - a(PUBCHEM:102336202) decreases act(p(FPLX:ERK)) + path(MESH:Schizophrenia) increases p(HGNC:MAPT, loc(MESH:Neurons)) - pmid:29179999 + pubmed:30061532 - a(PUBCHEM:102336202) decreases act(p(FPLX:NFkappaB)) + path(MESH:Schizophrenia) decreases bp(GO:"oligodendrocyte development") - pmid:29179999 + pubmed:30061532 - a(CHEBI:"N(5)-ethyl-L-glutamine") increases bp(GO:memory) + path(MESH:Schizophrenia) association path(MESH:Catatonia) - pmid:29179999 + pubmed:30061532 - a(CHEBI:"N(5)-ethyl-L-glutamine") decreases a(CHEBI:"amyloid-beta polypeptide 42") + path(MESH:Schizophrenia) association p(HGNC:DISC1) - pmid:29179999 + pubmed:30061532 - a(CHEBI:"N(5)-ethyl-L-glutamine") decreases bp(GO:"neuron death") + path(MESH:Schizophrenia) association p(HGNC:DISC1) - pmid:29179999 + pubmed:30061532 - a(CHEBI:"N(5)-ethyl-L-glutamine") decreases act(p(FPLX:ERK)) + path(MESH:Schizophrenia) association p(HGNC:DTNBP1) - pmid:29179999 + pubmed:30061532 - a(CHEBI:"N(5)-ethyl-L-glutamine") decreases act(p(HGNC:MAPK14)) + path(MESH:Schizophrenia) association p(HGNC:DTNBP1) - pmid:29179999 + pubmed:30061532 - a(CHEBI:"N(5)-ethyl-L-glutamine") decreases act(p(FPLX:NFkappaB)) + path(MESH:Schizophrenia) association p(HGNC:DPYSL2) - pmid:29179999 + pubmed:30562574 - a(CHEBI:"1,8-cineole") decreases a(CHEBI:"reactive oxygen species") + path(MESH:Schizophrenia) association p(HGNC:DPYSL2) - pmid:29179999 + pubmed:30061532 - a(CHEBI:"1,8-cineole") decreases a(CHEBI:"nitric oxide") + path(MESH:Schizophrenia) negativeCorrelation act(a(GO:microtubule)) - pmid:29179999 + pubmed:30061532 - a(CHEBI:"1,8-cineole") decreases p(HGNC:TNF) + path(MESH:Schizophrenia) association bp(GO:"protein kinase B signaling") - pmid:29179999 + pubmed:30061532 - a(CHEBI:"1,8-cineole") decreases p(HGNC:IL1B) + path(MESH:Schizophrenia) decreases bp(GO:"protein kinase B signaling") - pmid:29179999 + pubmed:30061532 - a(CHEBI:"1,8-cineole") decreases p(HGNC:IL6) + path(MESH:Schizophrenia) association bp(GO:"protein kinase B signaling") - pmid:29179999 + pubmed:30061532 - a(CHEBI:"1,8-cineole") decreases p(HGNC:NOS2) + path(MESH:Schizophrenia) decreases p(FPLX:AKT) - pmid:29179999 + pubmed:30061532 - a(CHEBI:"1,8-cineole") decreases p(HGNC:PTGS2) + path(MESH:Schizophrenia) association p(HGNC:NRG1) - pmid:29179999 + pubmed:30061532 - a(CHEBI:"1,8-cineole") decreases p(FPLX:NFkappaB) + path(MESH:Schizophrenia) association p(HGNC:NRG1) - pmid:29179999 + pubmed:30061532 - a(PUBCHEM:442534) increases bp(GO:memory) + path(MESH:Schizophrenia) association p(HGNC:ERBB4) - pmid:29179999 + pubmed:30061532 - a(PUBCHEM:442534) decreases a(HBP:"amyloid-beta aggregates") + path(MESH:Schizophrenia) association act(p(HGNC:MTOR)) - pmid:29179999 + pubmed:30061532 - a(PUBCHEM:442534) decreases path(MESH:"Alzheimer Disease") + path(MESH:Schizophrenia) negativeCorrelation act(p(HGNC:MTOR)) - pmid:29179999 + pubmed:30061532 - a(PUBCHEM:442534) decreases act(p(FPLX:GSK3)) + path(MESH:Schizophrenia) negativeCorrelation p(HGNC:CDK5R1) - pmid:29179999 + pubmed:30061532 - a(PUBCHEM:442534) decreases act(p(FPLX:NFkappaB)) + path(MESH:Schizophrenia) positiveCorrelation act(p(HGNC:CDK5)) - pmid:29179999 + pubmed:30061532 - a(PUBCHEM:442534) decreases bp(GO:"NLRP3 inflammasome complex assembly") + path(MESH:Schizophrenia) association p(HGNC:ULK1, var("?")) - pmid:29179999 + pubmed:30061532 - a(PUBCHEM:442534) decreases p(HGNC:TNF) + path(MESH:Schizophrenia) negativeCorrelation bp(GO:autophagy) - pmid:29179999 + pubmed:30061532 - a(PUBCHEM:442534) decreases p(HGNC:IL1B) + path(MESH:Schizophrenia) negativeCorrelation bp(GO:autophagy) - pmid:8282104 + pubmed:30061532 - p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(Ph)) + path(MESH:Schizophrenia) negativeCorrelation bp(GO:autophagy) - pmid:8282104 + pubmed:30061532 - p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 199)) + path(MESH:Schizophrenia) decreases p(HGNC:BECN1) - pmid:8282104 + pubmed:30061532 - p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) + path(MESH:Schizophrenia) decreases p(HGNC:BECN1) - pmid:8282104 + pubmed:30061532 - p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 235)) + path(MESH:Schizophrenia) decreases p(HGNC:ULK2) - pmid:8282104 + pubmed:30061532 - p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + path(MESH:Schizophrenia) decreases p(HGNC:ATG3) - pmid:8282104 + pubmed:30061532 - p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + path(MESH:Schizophrenia) decreases r(HGNC:BECN1) - pmid:8282104 + pubmed:30061532 - p(FPLX:GSK3) association a(GO:microtubule) + path(MESH:Schizophrenia) decreases p(HGNC:ADNP) - pmid:8282104 + pubmed:30061532 - p(FPLX:GSK3) association a(HBP:HBP00006) + path(MESH:Schizophrenia) decreases p(HGNC:ADNP2) - pmid:8282104 + pubmed:19126755 - p(FPLX:GSK3) increases rxn(reactants(p(HGNC:MAPT)), products(p(HGNC:MAPT, pmod(Ph)))) + path(MESH:Schizophrenia) negativeCorrelation act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:8282104 + pubmed:19126755 - p(FPLX:GSK3) positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:Schizophrenia) association path(MESH:"Sensory Gating") - pmid:27288790 + pubmed:19126755 - bp(GO:"negative regulation of neuron apoptotic process") association p(FPLX:NFkappaB) + path(MESH:Schizophrenia) association path(MESH:"Sensory Gating") - pmid:12428809 + pubmed:24511233 - bp(GO:"negative regulation of neuron apoptotic process") association sec(p(HGNC:APP)) + path(MESH:Schizophrenia) association path(MESH:"Cognitive Dysfunction") - pmid:27288790 + pubmed:24511233 - bp(GO:"neuron differentiation") association p(FPLX:NFkappaB) + path(MESH:Schizophrenia) association bp(GO:cognition) - pmid:24590577 + pubmed:19721446 - bp(GO:"neuron differentiation") association p(HGNC:CHRM1) + path(MESH:Schizophrenia) association bp(GO:cognition) - pmid:27807169 + pubmed:24511233 - bp(GO:"neuron differentiation") positiveCorrelation act(p(RGD:Cdk5)) + path(MESH:Schizophrenia) association bp(GO:behavior) - pmid:28884684 + pubmed:24511233 - bp(GO:"neuron differentiation") positiveCorrelation act(p(HGNC:DYRK1A), ma(kin)) + path(MESH:Schizophrenia) decreases bp(GO:"synaptic transmission, cholinergic") - pmid:27288790 + pubmed:24511233 - bp(GO:"regulation of synaptic plasticity") association p(FPLX:NFkappaB) + path(MESH:Schizophrenia) association bp(GO:"synaptic transmission, cholinergic") - pmid:27288790 + pubmed:24511233 - bp(GO:"regulation of synaptic plasticity") negativeCorrelation path(MESH:"Alzheimer Disease") + path(MESH:Schizophrenia) association path(MESH:"Memory, Short-Term") - pmid:30444369 + pubmed:24511233 - bp(GO:"regulation of synaptic plasticity") association p(HGNC:SH3GL2) + path(MESH:Schizophrenia) association path(MESH:Attention) - pmid:17009926 + pubmed:24511233 - bp(GO:"regulation of synaptic plasticity") association p(FPLX:CHRN) + path(MESH:Schizophrenia) association path(MESH:"Executive Function") - pmid:17009926 + pubmed:24511233 - bp(GO:"regulation of synaptic plasticity") association p(FPLX:CHRN) + path(MESH:Schizophrenia) association bp(GO:"synaptic transmission, glutamatergic") - pmid:24590577 + pubmed:24511233 - bp(GO:"regulation of synaptic plasticity") association p(HGNC:CHRM1) + path(MESH:Schizophrenia) association bp(GO:"gamma-aminobutyric acid signaling pathway") - pmid:30106381 + pubmed:17009926 - bp(GO:"regulation of synaptic plasticity") association p(HGNC:DLG4) + path(MESH:Schizophrenia) association p(FPLX:CHRN) - pmid:22908190 + pubmed:17009926 - bp(GO:"regulation of synaptic plasticity") association bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + path(MESH:Schizophrenia) association p(FPLX:CHRN) - pmid:22908190 + pubmed:21482353 - bp(GO:"regulation of synaptic plasticity") association bp(GO:endocytosis) + path(MESH:Schizophrenia) association act(p(FPLX:CHRN)) - pmid:22908190 + pubmed:11230871 - bp(GO:"regulation of synaptic plasticity") association bp(GO:autophagy) + path(MESH:Schizophrenia) association p(FPLX:CHRN) - pmid:26631930 + pubmed:21482353 - bp(GO:"regulation of synaptic plasticity") association p(HGNC:MAPT) + path(MESH:Schizophrenia) positiveCorrelation p(HGNC:CHRNA7, var("?")) - pmid:27288790 + pubmed:21482353 - p(FPLX:IKB, pmod(Ph)) increases deg(p(FPLX:IKB)) + path(MESH:Schizophrenia) association bp(GO:"GABAergic neuron differentiation") - pmid:27288790 + pubmed:21482353 - p(FPLX:IKB, pmod(Ph)) increases act(p(FPLX:NFkappaB)) + path(MESH:Schizophrenia) increases act(a(MESH:Hippocampus)) - pmid:27288790 + pubmed:21482353 - p(FPLX:NFkappaB, pmod(Ph, Ser, 536)) increases act(p(HGNC:RELA)) + path(MESH:Schizophrenia) association g(HGNC:CHRFAM7A, var("?")) - pmid:27288790 + pubmed:21482353 - bp(MESH:"Membrane Fluidity") association a(CHEBI:"reactive oxygen species") + path(MESH:Schizophrenia) association a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") - pmid:27288790 + pubmed:21482353 - bp(GO:"ion transport") association a(CHEBI:"reactive oxygen species") + path(MESH:Schizophrenia) positiveCorrelation path(MESH:"Tobacco Use Disorder") - pmid:30061532 + pubmed:21482353 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) association path(MESH:"Lewy Body Disease") + path(MESH:Schizophrenia) association p(HGNC:PEMT, var("?")) - pmid:30061532 + pubmed:11230871 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:Schizophrenia) negativeCorrelation complex(CONSO:"alpha-7-containing nAChR") - pmid:29758300 + pubmed:11230871 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases path(MESH:"Alzheimer Disease") + path(MESH:Schizophrenia) causesNoChange complex(CONSO:"alpha-4-containing nAChR") - pmid:30145931 + pubmed:19721446 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:Schizophrenia) association bp(MESH:"Sensory Gating") - pmid:17403556 + pubmed:19721446 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:Schizophrenia) decreases p(HGNC:CHRNA7) - pmid:25374103 + pubmed:22040696 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:Schizophrenia) negativeCorrelation p(HGNC:CHRNA7) - pmid:26631930 + pubmed:22040696 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:Schizophrenia) positiveCorrelation r(HGNC:RIC3) - pmid:24401760 + pubmed:17950019 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:CRTC2) association p(HGNC:STK11) - pmid:30061532 + pubmed:17950019 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation path(MESH:"Frontotemporal Dementia") + p(HGNC:CRTC2) positiveCorrelation path(MESH:"Diabetes Mellitus, Type 2") - pmid:30061532 + pubmed:17950019 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation path(MESH:Schizophrenia) + path(MESH:"Diabetes Mellitus, Type 2") positiveCorrelation p(HGNC:STK11) - pmid:30061532 + pubmed:17950019 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation p(HGNC:CDK5) + path(MESH:"Diabetes Mellitus, Type 2") positiveCorrelation p(HGNC:CRTC2) - pmid:17009926 + pubmed:22236693 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation p(HGNC:CHRNA7) + path(MESH:"Diabetes Mellitus, Type 2") association g(RGD:Ngfr) - pmid:17009926 + pubmed:22107728 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation p(HGNC:CHRNA4) + path(MESH:"Diabetes Mellitus, Type 2") association g(DBSNP:rs2251101) - pmid:11230871 + pubmed:23279143 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) negativeCorrelation p(FPLX:CHRN) + path(MESH:"Diabetes Mellitus, Type 2") association p(HGNC:SORCS1) - pmid:26837465 + pubmed:23279143 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) association p(HGNC:ESR1) + path(MESH:"Diabetes Mellitus, Type 2") association g(DBSNP:rs7907690) - pmid:19277525 + pubmed:19732809 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases a(GO:"neurofibrillary tangle") + path(MESH:"Diabetes Mellitus, Type 2") negativeCorrelation p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) - pmid:22908190 + pubmed:23791179 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) association a(GO:"neurofibrillary tangle") + bp(GO:"collateral sprouting") positiveCorrelation p(HGNC:STK11) - pmid:22299660 + pubmed:23791179 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases bp(GO:"microtubule polymerization") + bp(GO:"collateral sprouting") positiveCorrelation p(HGNC:NUAK1) - pmid:26631930 + pubmed:23791179 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases bp(GO:"microtubule polymerization") + p(HGNC:NUAK1) positiveCorrelation bp(GO:"collateral sprouting") - pmid:22299660 + pubmed:21861815 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) negativeCorrelation act(p(FPLX:PPP2)) + bp(GO:"glucose import") negativeCorrelation path(DOID:"Alzheimer's disease") - pmid:21722302 + pubmed:22005930 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases bp(GO:"cytoskeleton organization") + g(HGNC:STK11) negativeCorrelation path(MESH:Schizophrenia) - pmid:29758300 + pubmed:22005930 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + g(HGNC:STK11) association g(DBSNP:rs3764640) - pmid:30985105 + pubmed:22005930 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + g(HGNC:STK11) association path(MESH:"Alzheimer Disease") - pmid:26631930 + pubmed:16530014 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + tloc(a(CHEBI:glucose), fromLoc(MESH:Liver), toLoc(MESH:Blood)) negativeCorrelation p(HGNC:STK11) - pmid:29758300 + pubmed:16530014 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases a(HBP:"Tau aggregates") + a(CHEBI:glucose) negativeCorrelation p(HGNC:STK11) - pmid:21882945 + pubmed:30985105 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases a(HBP:"Tau aggregates") + a(CHEBI:glucose) positiveCorrelation p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) + + - pmid:26458742 + pubmed:16530014 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases a(HBP:"Tau aggregates") + path(MESH:Hyperglycemia) negativeCorrelation p(HGNC:STK11) - pmid:26631930 + pubmed:30985105 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases a(HBP:"Tau aggregates") + path(MESH:Hyperglycemia) increases p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) - pmid:29758300 + pubmed:16530014 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases bp(GO:"microtubule depolymerization") + a(CHEBI:metformin) decreases a(CHEBI:glucose) - pmid:30145931 + pubmed:30116051 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation path(MESH:Tauopathies) + a(CHEBI:metformin) increases act(p(FPLX:AMPK)) - pmid:22611162 + pubmed:30116051 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases bp(GO:"axonal transport") + a(CHEBI:metformin) increases bp(GO:macroautophagy) - pmid:26631930 + pubmed:30116051 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases bp(GO:"axonal transport") + a(CHEBI:metformin) increases bp(MESH:Longevity) - pmid:22611162 + pubmed:30116051 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases bp(GO:"synaptic signaling") + a(CHEBI:metformin) decreases a(CHEBI:amyloid-beta) - pmid:22611162 + pubmed:30116051 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases bp(GO:"maintenance of synapse structure") + a(CHEBI:metformin) decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:21734277 + pubmed:30116051 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) association p(HBP:"Tau epitope, AT8", pmod(Ph)) + a(CHEBI:metformin) decreases bp(GO:"neuron death") - pmid:30985105 + pubmed:17234589 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases act(p(HGNC:MAPT)) + bp(MESH:"Osmolar Concentration") association p(FB:Lkb1) - pmid:26195256 + pubmed:17234589 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation), loc(MESH:"Cerebrospinal Fluid")) positiveCorrelation p(HGNC:MAPT, loc(MESH:"Neurofibrillary Tangles")) + bp(MESH:"Osmolar Concentration") increases p(FB:tau, pmod(go:0006468 ! "protein phosphorylation")) - pmid:26631930 + pubmed:14556719 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) + bp(MESH:"Osmolar Concentration") positiveCorrelation bp(GO:"response to unfolded protein") - pmid:26631930 + pubmed:17234589 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) + p(FB:Lkb1) association bp(MESH:"Osmolar Concentration") - pmid:30985105 + pubmed:17234589 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases a(HBP:"Tau oligomers") + p(FB:Lkb1) association p(HGNC:APP) - pmid:26195256 + pubmed:17234589 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) association a(MESH:"Neurofibrillary Tangles") + p(FB:Lkb1) increases p(INTERPRO:"Serine/threonine-protein kinase MARK/par1", pmod(go:0006468 ! "protein phosphorylation")) + + - pmid:26195256 + pubmed:17234589 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) association a(MESH:"Neuropil Threads") + p(INTERPRO:"Serine/threonine-protein kinase MARK/par1", pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation act(p(INTERPRO:"Serine/threonine-protein kinase MARK/par1")) - pmid:26631930 + pubmed:25932647 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases complex(p(HGNC:MAPK8IP1), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) + p(INTERPRO:"Serine/threonine-protein kinase MARK/par1", pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation act(p(INTERPRO:"Serine/threonine-protein kinase MARK/par1")) + + - pmid:26631930 + pubmed:17234589 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases complex(p(HGNC:MAPK8IP1), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) + act(p(INTERPRO:"Serine/threonine-protein kinase MARK/par1")) positiveCorrelation p(INTERPRO:"Serine/threonine-protein kinase MARK/par1", pmod(go:0006468 ! "protein phosphorylation")) - pmid:26631930 + pubmed:25932647 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases complex(GO:"filamentous actin") + act(p(INTERPRO:"Serine/threonine-protein kinase MARK/par1")) positiveCorrelation p(INTERPRO:"Serine/threonine-protein kinase MARK/par1", pmod(go:0006468 ! "protein phosphorylation")) - pmid:26631930 + pubmed:17234589 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) increases path(HBP:Neurodegeneration) + act(p(INTERPRO:"Serine/threonine-protein kinase MARK/par1")) increases p(FB:tau, pmod(go:0006468 ! "protein phosphorylation")) - pmid:26631930 + pubmed:25932647 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases act(a(GO:synapse)) + p(INTERPRO:"Serine/threonine-protein kinase MARK/par1") negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:23487739 + pubmed:25932647 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) decreases a(GO:microtubule) + p(INTERPRO:"Serine/threonine-protein kinase MARK/par1") negativeCorrelation path(MESH:"Autistic Disorder") - pmid:19732809 + pubmed:25932647 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) negativeCorrelation p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) + p(INTERPRO:"Serine/threonine-protein kinase MARK/par1") negativeCorrelation path(MESH:Neoplasms) - pmid:25378699 + pubmed:25932647 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation p(HGNC:MAPT, pmod(Sumo, Lys, 340)) + path(MESH:"Autistic Disorder") negativeCorrelation p(INTERPRO:"Serine/threonine-protein kinase MARK/par1") - pmid:19623258 + pubmed:17009926 - p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) association a(CHEBI:"quinolinic acid") + path(MESH:"Autistic Disorder") association p(FPLX:CHRN) - pmid:30061532 + pubmed:17009926 - bp(GO:autophagy) increases deg(p(MESH:Proteins, pmod(HBP:misfolded))) + path(MESH:"Autistic Disorder") negativeCorrelation act(p(FPLX:CHRN)) - pmid:21722302 + pubmed:17009926 - bp(GO:autophagy) decreases p(MESH:Proteins, pmod(HBP:misfolded)) + path(MESH:"Autistic Disorder") negativeCorrelation p(FPLX:CHRN) - pmid:21722302 + pubmed:30106381 - bp(GO:autophagy) increases deg(p(MESH:Proteins, pmod(HBP:misfolded))) + path(MESH:"Autistic Disorder") association p(HGNC:ADNP) - pmid:30061532 + pubmed:30106381 - bp(GO:autophagy) decreases path(MESH:"Neurodegenerative Diseases") + path(MESH:"Autistic Disorder") association a(PUBCHEM:9832404) - pmid:18930136 + pubmed:25932647 - bp(GO:autophagy) association path(MESH:"Neurodegenerative Diseases") + path(MESH:Neoplasms) negativeCorrelation p(INTERPRO:"Serine/threonine-protein kinase MARK/par1") - pmid:18930136 + pubmed:19126755 - bp(GO:autophagy) negativeCorrelation path(MESH:"Neurodegenerative Diseases") + path(MESH:Neoplasms) association path(MESH:"Tobacco Use Disorder") - pmid:30061532 + pubmed:28901280 - bp(GO:autophagy) negativeCorrelation act(p(HGNC:MTOR)) + path(MESH:Neoplasms) association p(HGNC:CHRNA7) - pmid:30061532 + pubmed:22020111 - bp(GO:autophagy) regulates act(p(HGNC:MTOR)) + path(MESH:Neoplasms) negativeCorrelation p(HGNC:AIFM2) - pmid:30106381 + pubmed:22020111 - bp(GO:autophagy) association p(HGNC:MTOR) + path(MESH:Neoplasms) negativeCorrelation p(HGNC:GPX3) - pmid:29758300 + pubmed:23454242 - bp(GO:autophagy) negativeCorrelation p(HGNC:MTOR) + path(MESH:Neoplasms) association p(FPLX:PPP2) - pmid:18930136 + pubmed:23454242 - bp(GO:autophagy) negativeCorrelation p(HGNC:MTOR) + path(MESH:Neoplasms) negativeCorrelation act(p(FPLX:PPP2)) - pmid:30061532 + pubmed:22299660 - bp(GO:autophagy) decreases act(a(CHEBI:methamphetamine)) + path(MESH:Neoplasms) association p(FPLX:PPP2) - pmid:30061532 + pubmed:30740335 - bp(GO:autophagy) decreases act(a(CHEBI:methamphetamine)) + path(MESH:Neoplasms) association path(MESH:"Endoplasmic Reticulum Stress") - pmid:30061532 + pubmed:25784053 - bp(GO:autophagy) decreases sec(a(CHEBI:dopamine)) + path(MESH:Neoplasms) association act(p(HGNC:HSF1)) - pmid:30061532 + pubmed:18930136 - bp(GO:autophagy) decreases sec(a(CHEBI:dopamine)) + path(MESH:Neoplasms) negativeCorrelation bp(GO:"cellular protein catabolic process") - pmid:30061532 + pubmed:24563850 - bp(GO:autophagy) association bp(GO:"dopamine secretion, neurotransmission") + path(MESH:Neoplasms) increases p(HGNCGENEFAMILY:"Small heat shock proteins") - pmid:30061532 + pubmed:24563850 - bp(GO:autophagy) negativeCorrelation path(MESH:Schizophrenia) + path(MESH:Neoplasms) association bp(GO:"protein oxidation") - pmid:30061532 + pubmed:29311797 - bp(GO:autophagy) negativeCorrelation path(MESH:Schizophrenia) + path(MESH:Neoplasms) association p(HGNC:STUB1) - pmid:30061532 + pubmed:25932647 - bp(GO:autophagy) negativeCorrelation path(MESH:Schizophrenia) + p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits") increases p(INTERPRO:"Serine/threonine-protein kinase MARK/par1") - pmid:30061532 + pubmed:25932647 - bp(GO:autophagy) association p(HGNC:BECN1) + p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits") association p(RGD:Prkaca) + + - pmid:26702100 + pubmed:19419557 - bp(GO:autophagy) association p(HGNC:BECN1) + act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) association complex(a(CONSO:"amyloid-beta oligomers"), p(HGNC:GRIN1)) - pmid:30061532 + pubmed:21871088 - bp(GO:autophagy) association p(HGNC:ULK2) + act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) increases bp(GO:"calcium ion import") - pmid:30061532 + pubmed:20556492 - bp(GO:autophagy) association p(HGNC:ATG3) + act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) increases bp(GO:"calcium ion import") - pmid:30061532 + pubmed:19126755 - bp(GO:autophagy) negativeCorrelation path(MESH:Hallucinations) + act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) increases a(CHEBI:anandamide) + + - pmid:30106381 + pubmed:24511233 - bp(GO:autophagy) association p(HGNC:ADNP) + p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits") regulates bp(MESH:"Neuronal Plasticity") - pmid:30106381 + pubmed:24511233 - bp(GO:autophagy) association p(HGNC:ADNP) + p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits") association bp(GO:cognition) - pmid:30106381 + pubmed:22530628 - bp(GO:autophagy) association a(PUBCHEM:9832404) + p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits") increases act(a(CHEBI:"glutamate(2-)")) - pmid:22020111 + pubmed:22530628 - bp(GO:autophagy) positiveCorrelation complex(p(HGNC:BAG3), p(HGNC:HSPB8)) + p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits") increases p(HGNC:ARC) + + + + + + - pmid:30012004 + pubmed:16273023 - bp(GO:autophagy) positiveCorrelation path(MESH:"Huntington Disease") + act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) decreases bp(MESH:D017774) - pmid:21722302 + pubmed:20556492 - bp(GO:autophagy) increases bp(MESH:Neuroprotection) + act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) association bp(GO:"calcium ion homeostasis") - pmid:21722302 + pubmed:20556492 - bp(GO:autophagy) negativeCorrelation path(MESH:"Alzheimer Disease") + tloc(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits"), fromLoc(GO:cytoplasm), toLoc(GO:"plasma membrane")) increases act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) - pmid:29758300 + pubmed:20556492 - bp(GO:autophagy) negativeCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) increases path(MP:0008235) + + - pmid:22908190 + pubmed:30988501 - bp(GO:autophagy) association path(MESH:"Alzheimer Disease") + p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits") positiveCorrelation path(DOID:schizophrenia) - pmid:22908190 + pubmed:25932647 - bp(GO:autophagy) association path(MESH:"Alzheimer Disease") + p(RGD:Prkaca) association p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits") - pmid:29758300 + pubmed:25932647 - bp(GO:autophagy) positiveCorrelation bp(GO:"lysosomal protein catabolic process") + p(RGD:Prkaca) increases p(RGD:Stk11, pmod(go:0006468 ! "protein phosphorylation", Ser, 431)) + + - pmid:22908190 + pubmed:25932647 - bp(GO:autophagy) positiveCorrelation bp(GO:"lysosomal protein catabolic process") + p(RGD:Stk11) increases p(INTERPRO:"Serine/threonine-protein kinase MARK/par1", pmod(go:0006468 ! "protein phosphorylation")) - pmid:29758300 + pubmed:31346362 - bp(GO:autophagy) increases deg(p(MESH:Proteins, pmod(HBP:misfolding))) + path(DOID:amyloidosis) increases p(CONSO:"Tau aggregates", loc(GO:cytosol)) - pmid:18930136 + pubmed:31346362 - bp(GO:autophagy) regulates deg(p(MESH:Proteins, pmod(HBP:misfolding))) + path(DOID:amyloidosis) increases p(CONSO:"huntingtin aggregates", loc(GO:nucleus)) - pmid:29758300 + pubmed:31346362 - bp(GO:autophagy) increases deg(a(HBP:"protein aggregates")) + path(DOID:amyloidosis) increases p(CONSO:"amyloid-beta fibrils", loc(GO:"endoplasmic reticulum")) - pmid:22908190 + pubmed:31346362 - bp(GO:autophagy) increases deg(a(HBP:"protein aggregates")) + path(DOID:amyloidosis) increases tloc(p(CONSO:"amyloid-beta fibrils"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:22908190 + pubmed:31346362 - bp(GO:autophagy) increases deg(a(HBP:"protein aggregates")) + path(DOID:amyloidosis) increases p(CONSO:"amyloid-beta fibrils", loc(GO:"extracellular space")) - pmid:22908190 + pubmed:31346362 - bp(GO:autophagy) increases deg(a(HBP:"protein aggregates")) + path(DOID:amyloidosis) increases p(CONSO:"amyloid-beta fibrils", loc(MESH:Plasma)) - pmid:29758300 + pubmed:31346362 - bp(GO:autophagy) association p(HGNC:MAPT, pmod(Ph)) + path(DOID:amyloidosis) increases p(NCIT:C16720) - pmid:29758300 + pubmed:31346362 - bp(GO:autophagy) increases deg(p(HGNC:MAPT, pmod(Ph))) + path(DOID:amyloidosis) increases p(NCIT:C16720, frag("?")) - pmid:29626319 + pubmed:31346362 - bp(GO:autophagy) increases deg(p(HGNC:MAPT, pmod(Ph))) + path(DOID:amyloidosis) increases p(HGNC:SAA1) - pmid:29758300 + pubmed:31346362 - bp(GO:autophagy) association a(HBP:"Tau aggregates") + path(DOID:amyloidosis) increases p(HGNC:TTR) - pmid:29758300 + pubmed:31346362 - bp(GO:autophagy) increases deg(p(HGNC:SNCA)) + path(DOID:amyloidosis) increases p(HGNC:FGA) - pmid:18930136 + pubmed:31346362 - bp(GO:autophagy) increases deg(p(HGNC:SNCA)) + path(DOID:amyloidosis) increases p(HGNC:B2M) - pmid:30985105 + pubmed:31346362 - bp(GO:autophagy) increases act(p(HGNC:SNCA)) + path(DOID:amyloidosis) increases p(HGNC:LYZ) - pmid:30985105 + pubmed:31346362 - bp(GO:autophagy) increases p(HGNC:SNCA) + path(DOID:amyloidosis) increases p(HGNC:GSN) - pmid:29758300 + pubmed:31346362 - bp(GO:autophagy) decreases a(CHEBI:lipid) + path(DOID:amyloidosis) increases a(MESH:Lipofuscin) - pmid:29758300 + pubmed:21156028 - bp(GO:autophagy) increases deg(a(CHEBI:lipid)) + path(DOID:amyloidosis) increases bp(GO:"neuron death") - pmid:29758300 + pubmed:28760828 - bp(GO:autophagy) negativeCorrelation a(CHEBI:lipid) + p(CONSO:"Tau aggregates") association act(p(HGNC:EP300)) - pmid:29758300 + pubmed:28760828 - bp(GO:autophagy) increases deg(a(CHEBI:carbohydrate)) + p(CONSO:"Tau aggregates") association act(p(HGNC:HDAC6)) - pmid:29758300 + pubmed:28760828 - bp(GO:autophagy) increases deg(p(HGNC:MAPT)) + p(CONSO:"Tau aggregates") association p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) - pmid:30145931 + pubmed:28760828 - bp(GO:autophagy) decreases p(HGNC:MAPT) + p(CONSO:"Tau aggregates") negativeCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Gln, 259), pmod(go:0006473 ! "protein acetylation", Gln, 290), pmod(go:0006473 ! "protein acetylation", Gln, 321), pmod(go:0006473 ! "protein acetylation", Gln, 353), var("p.Lys259Gln"), var("p.Lys290Gln"), var("p.Lys321Gln"), var("p.Lys352Gln")) - pmid:24027553 + pubmed:25031639 - bp(GO:autophagy) increases deg(p(HGNC:MAPT)) + p(CONSO:"Tau aggregates", loc(GO:cytosol)) increases p(MESH:"Neurofibrillary Tangles") - pmid:23528736 + pubmed:25031639 - bp(GO:autophagy) increases deg(p(HGNC:MAPT)) + p(CONSO:"Tau aggregates", loc(GO:cytosol)) increases p(CONSO:"paired helical filaments") - pmid:25374103 + pubmed:25031639 - bp(GO:autophagy) increases deg(p(HGNC:MAPT)) + p(CONSO:"Tau aggregates") negativeCorrelation bp(GO:"axonal transport") - pmid:29626319 + pubmed:25031639 - bp(GO:autophagy) increases deg(p(HGNC:MAPT)) + p(CONSO:"Tau aggregates") negativeCorrelation bp(GO:"synaptic signaling") - pmid:29626319 + pubmed:29844403 - bp(GO:autophagy) increases deg(p(HGNC:MAPT)) + p(CONSO:"Tau aggregates") increases path(HP:"Abnormal synaptic transmission") + + - pmid:22908190 + pubmed:29661268 - bp(GO:autophagy) increases deg(a(GO:organelle)) + p(CONSO:"Tau aggregates") negativeCorrelation p(HGNC:STUB1) - pmid:22908190 + pubmed:29661268 - bp(GO:autophagy) increases deg(a(GO:organelle)) + p(CONSO:"Tau aggregates") negativeCorrelation p(HGNCGENEFAMILY:"Heat shock 70kDa proteins") - pmid:22908190 + pubmed:29661268 - bp(GO:autophagy) increases deg(a(GO:organelle)) + p(CONSO:"Tau aggregates") decreases act(p(MESH:"Proteasome Endopeptidase Complex")) + + + + + + - pmid:18930136 + pubmed:26751493 - bp(GO:autophagy) increases tloc(a(GO:organelle), fromLoc(GO:cytoplasm), toLoc(GO:lysosome)) + p(CONSO:"Tau aggregates") association a(CHEBI:heparin) + + - pmid:18930136 + pubmed:26751493 - bp(GO:autophagy) increases deg(a(GO:organelle)) + p(CONSO:"Tau aggregates") increases complex(a(CHEBI:heparin), p(CONSO:"Tau aggregates")) - pmid:18930136 + pubmed:26751493 - bp(GO:autophagy) increases deg(a(GO:organelle)) + p(CONSO:"Tau aggregates") partOf complex(a(CHEBI:heparin), p(CONSO:"Tau aggregates")) - pmid:22908190 + pubmed:26195256 - bp(GO:autophagy) negativeCorrelation bp(GO:"proteasomal protein catabolic process") + p(CONSO:"Tau aggregates") association path(MESH:"Brain Injuries, Traumatic") - pmid:22908190 + pubmed:26195256 - bp(GO:autophagy) increases deg(p(HBP:"protein aggregates", pmod(Ub))) + p(CONSO:"Tau aggregates") increases path(MESH:"Neurodegenerative Diseases") - pmid:22908190 + pubmed:24869773 - bp(GO:autophagy) increases rxn(reactants(p(HGNC:APP)), products(a(MESH:"Amyloid beta-Peptides"))) + p(CONSO:"Tau aggregates") association p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 311)) - pmid:22908190 + pubmed:19517062 - bp(GO:autophagy) increases deg(a(CHEBI:"amyloid-beta")) + p(CONSO:"Tau aggregates") increases bp(GO:"apoptotic process") - pmid:24844691 + pubmed:19517062 - bp(GO:autophagy) increases deg(a(CHEBI:"amyloid-beta")) + p(CONSO:"Tau aggregates") increases bp(GO:"necrotic cell death") + + - pmid:22908190 + pubmed:26751493 - bp(GO:autophagy) decreases path(MESH:Tauopathies) + p(CONSO:"Tau aggregates") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 274)) - pmid:22908190 + pubmed:24033439 - bp(GO:autophagy) decreases path(HBP:neurotoxicity) + p(CONSO:"Tau aggregates") increases a(GO:"neurofibrillary tangle") - pmid:22908190 + pubmed:28500862 - bp(GO:autophagy) increases path(HBP:neurotoxicity) + p(CONSO:"Tau aggregates") positiveCorrelation a(CHEBI:amyloid-beta) - pmid:30145931 + pubmed:27299292 - bp(GO:autophagy) decreases path(HBP:neurotoxicity) + p(CONSO:"huntingtin aggregates") positiveCorrelation path(DOID:"Huntington's disease") - pmid:22908190 + pubmed:31346362 - bp(GO:autophagy) association bp(GO:"regulation of synaptic plasticity") + p(CONSO:"amyloid-beta fibrils", loc(GO:intracellular)) increases bp(GO:"cellular respiration") - pmid:23746257 + pubmed:31346362 - bp(GO:autophagy) increases bp(GO:"protein catabolic process") + p(CONSO:"amyloid-beta fibrils", loc(GO:intracellular)) increases bp(GO:"reactive oxygen species biosynthetic process") - pmid:26195256 + pubmed:31346362 - bp(GO:autophagy) increases bp(GO:"protein catabolic process") + p(CONSO:"amyloid-beta fibrils", loc(GO:intracellular)) increases bp(GO:"cell death") - pmid:23746257 + pubmed:31346362 - bp(GO:autophagy) decreases a(MESH:"Protein Aggregates") + p(CONSO:"amyloid-beta fibrils") increases a(MESH:Alarmins) - pmid:18930136 + pubmed:27209302 - bp(GO:autophagy) increases bp(GO:"cellular protein catabolic process") + p(CONSO:"amyloid-beta fibrils", loc(MESH:Lysosomes)) increases deg(p(CONSO:"amyloid-beta fibrils")) - pmid:18930136 + pubmed:27209302 - bp(GO:autophagy) regulates bp(GO:"amino acid homeostasis") + deg(p(CONSO:"amyloid-beta fibrils")) association a(CHEBI:phosphoramidon) - pmid:18930136 + pubmed:27209302 - bp(GO:autophagy) increases tloc(a(MESH:Proteins), fromLoc(GO:cytoplasm), toLoc(GO:lysosome)) + act(p(CONSO:"amyloid-beta fibrils")) increases tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) - pmid:18930136 + pubmed:27209302 - bp(GO:autophagy) increases deg(a(MESH:Proteins)) + act(p(CONSO:"amyloid-beta fibrils")) causesNoChange act(p(HGNCGENEFAMILY:"MTOR complex 1")) - pmid:18930136 + pubmed:27209302 - bp(GO:autophagy) regulates bp(GO:"metabolic process") + act(p(CONSO:"amyloid-beta fibrils")) decreases p(HGNCGENEFAMILY:"MTOR complex 1", pmod(go:0006468 ! "protein phosphorylation")) - pmid:18930136 + pubmed:31346362 - bp(GO:autophagy) association bp(GO:"antigen processing and presentation") + p(HGNCGENEFAMILY:Aminopeptidases) decreases p(CONSO:"amyloid-beta fibrils") - pmid:18930136 + pubmed:24027553 - bp(GO:autophagy) decreases bp(MESH:Microbiota) + act(p(HGNCGENEFAMILY:Aminopeptidases)) increases deg(p(HGNC:MAPT)) - pmid:18930136 + pubmed:31346362 - bp(GO:autophagy) regulates bp(GO:"cell death") + p(CONSO:"amyloid-beta aggregates") increases path(DOID:amyloidosis) + + - pmid:18930136 + pubmed:31346362 - bp(GO:autophagy) increases deg(p(HGNC:SNCA, var("?"))) + p(CONSO:"amyloid-beta aggregates") increases bp(MESH:"Cell Hypoxia") - pmid:18930136 + pubmed:31346362 - bp(GO:autophagy) increases deg(a(HBP:"alpha-synuclein aggregates")) + p(CONSO:"amyloid-beta aggregates") increases act(p(HGNCGENEFAMILY:"NF-kappa B complex subunits")) - pmid:18930136 + pubmed:31346362 - bp(GO:autophagy) increases deg(a(HBP:"alpha-synuclein oligomers")) + p(CONSO:"amyloid-beta aggregates", loc(GO:intracellular)) increases bp(GO:autophagy) - pmid:18930136 + pubmed:31346362 - bp(GO:autophagy) regulates bp(GO:"neuron cellular homeostasis") + p(CONSO:"amyloid-beta aggregates", loc(GO:intracellular)) increases a(MESH:Lipofuscin) - pmid:18930136 + pubmed:31346362 - bp(GO:autophagy) decreases path(HBP:Neurodegeneration) + p(CONSO:"amyloid-beta aggregates") increases path(EFO:hypoxia) - pmid:18930136 + pubmed:31346362 - bp(GO:autophagy) decreases path(HBP:Neurodegeneration) + p(CONSO:"amyloid-beta aggregates") increases path(NCIT:C82901) - pmid:18930136 + pubmed:23516100 - bp(GO:autophagy) negativeCorrelation path(MESH:"Bulbo-Spinal Atrophy, X-Linked") + bp(GO:"cell death") association p(MESH:Proteins, frag("?")) - pmid:18930136 + pubmed:14556719 - bp(GO:autophagy) increases deg(p(HGNC:APP)) + bp(GO:"cell death") positiveCorrelation p(HGNC:GPR37) - pmid:18930136 + pubmed:23746257 - bp(GO:autophagy) negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + bp(GO:"cell death") negativeCorrelation bp(CONSO:Proteostasis) - pmid:18930136 + pubmed:18930136 - bp(GO:autophagy) negativeCorrelation act(complex(GO:"proteasome complex")) + bp(GO:"cell death") negativeCorrelation a(GO:aggresome) - pmid:28803412 + pubmed:18305152 - bp(GO:autophagy) increases a(HBP:HBP00093) + bp(GO:"cell death") negativeCorrelation p(HGNC:TARDBP) - pmid:30145931 + pubmed:27181519 - bp(GO:autophagy) increases deg(p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356))) + bp(GO:"cell death") association p(CONSO:"protein aggregates") - pmid:30116051 + pubmed:28669544 - bp(GO:autophagy) negativeCorrelation g(HGNC:PSEN1, var("?")) + bp(GO:"cell death") increases path(MESH:Neuropathology) - pmid:30116051 + pubmed:24561250 - bp(GO:autophagy) increases deg(p(HGNC:HTT, var("?"))) + bp(GO:"cell death") increases tloc(a(CHEBI:ATP), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + - pmid:23528736 + pubmed:31346362 - bp(GO:autophagy) negativeCorrelation a(CHEBI:"reactive oxygen species") + complex(p(CONSO:"amyloid-beta aggregates"), p(HGNCGENEFAMILY:"Long pentraxins")) decreases bp(GO:proteolysis) - pmid:24844691 + pubmed:31346362 - bp(GO:autophagy) increases deg(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) + complex(p(CONSO:"amyloid-beta aggregates"), p(HGNCGENEFAMILY:"Long pentraxins")) increases bp(GO:"macrophage activation") - pmid:27181519 + pubmed:29758300 - bp(GO:autophagy) increases deg(complex(GO:"ribonucleoprotein granule")) + bp(GO:proteolysis) decreases bp(GO:"neuron death") - pmid:27181519 + pubmed:14556719 - bp(GO:autophagy) association p(HGNC:SOD1, var("?")) + bp(GO:proteolysis) association p(HGNC:UBA3) - pmid:27181519 + pubmed:24027553 - bp(GO:autophagy) isA bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") + bp(GO:proteolysis) increases bp(GO:autophagy) - pmid:27181519 + pubmed:24027553 - bp(GO:autophagy) association a(CHEBI:"all-trans-retinoic acid") + bp(GO:proteolysis) decreases a(MESH:Autophagosomes) - pmid:27181519 + pubmed:29626319 - bp(GO:autophagy) negativeCorrelation path(MESH:"Motor Neuron Disease") + bp(GO:proteolysis) increases deg(a(CHEBI:amyloid-beta)) - pmid:27181519 + pubmed:31346362 - bp(GO:autophagy) negativeCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") + bp(GO:"macrophage activation") increases bp(GO:phagocytosis) - pmid:26702100 + pubmed:26445701 - bp(GO:autophagy) association path(MESH:"Amyotrophic Lateral Sclerosis") + bp(GO:"macrophage activation") increases path(HP:"CNS demyelination") - pmid:27181519 + pubmed:26445701 - bp(GO:autophagy) increases p(HGNC:TARDBP, frag("?"), pmod(GO:"protein complex oligomerization")) + bp(GO:"macrophage activation") increases path(MESH:"Diffuse Axonal Injury") - pmid:27181519 + pubmed:26445701 - bp(GO:autophagy) increases p(HGNC:TARDBP, frag("?"), pmod(HBP:"protein aggregation")) + bp(GO:"macrophage activation") increases bp(GO:"positive regulation of oligodendrocyte apoptotic process") - pmid:27181519 + pubmed:30967783 - bp(GO:autophagy) increases deg(p(HGNC:FUS, pmod(MESH:"Protein Aggregation, Pathological"))) + bp(GO:"macrophage activation") increases tloc(a(MESH:Chemokines), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:27181519 + pubmed:30967783 - bp(GO:autophagy) increases deg(p(HGNC:TARDBP, pmod(HBP:"protein aggregation"))) + bp(GO:"macrophage activation") increases tloc(a(MESH:Cytokines), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:27181519 + pubmed:30967783 - bp(GO:autophagy) association complex(p(HGNC:MAP1LC3A), p(HGNC:OPTN)) + bp(GO:"macrophage activation") increases path(DOID:"multiple sclerosis") - pmid:27181519 + pubmed:30967783 - bp(GO:autophagy) increases deg(p(HGNC:HTT)) + bp(GO:"macrophage activation") increases a(CHEBI:"prostaglandin E2") - pmid:27181519 + pubmed:30967783 - bp(GO:autophagy) association a(CHEBI:"alpha,alpha-trehalose") + bp(GO:"macrophage activation") association a(DRUGBANK:"Ethyl pyruvate") - pmid:27181519 + pubmed:30967783 - bp(GO:autophagy) association a(CHEBI:"lithium(1+)") + bp(GO:"macrophage activation") association a(CHEBI:spermidine) - pmid:27181519 + pubmed:30967783 - bp(GO:autophagy) association a(CHEBI:"withaferin A") + bp(GO:"macrophage activation") association a(CHEBI:"bryostatin 1") - pmid:26702100 + pubmed:30967783 - bp(GO:autophagy) association p(HGNC:ATG5) + bp(GO:"macrophage activation") association a(CHEBI:forskolin) - pmid:26702100 + pubmed:30967783 - bp(GO:autophagy) association p(HGNC:ATG9B) + bp(GO:"macrophage activation") association a(DRUGBANK:Lenalidomide) - pmid:23702978 + pubmed:21482353 - bp(GO:autophagy) regulates bp(GO:"apoptotic process") + bp(GO:"macrophage activation") association p(CONSO:"alpha-7-containing nAChR") - pmid:23702978 + pubmed:31413141 - bp(GO:autophagy) regulates complex(GO:"inflammasome complex") + bp(GO:"macrophage activation") increases p(HGNC:TREM2) - pmid:23702978 + pubmed:31413141 - bp(GO:autophagy) decreases act(complex(GO:"inflammasome complex")) + bp(GO:"macrophage activation") increases p(HGNC:MS4A4A) - pmid:23702978 + pubmed:31413141 - bp(GO:autophagy) decreases sec(p(HGNC:IL1B)) + bp(GO:"macrophage activation") increases p(HGNC:TREM2, frag("?")) + + + + - pmid:27288790 + pubmed:31346362 - a(CHEBI:"hydrogen peroxide") increases act(p(FPLX:NFkappaB)) + bp(MESH:"Cell Hypoxia") increases act(p(HGNC:HIF1A)) - pmid:27288790 + pubmed:31346362 - a(CHEBI:"hydrogen peroxide") increases act(p(FPLX:ERK)) + p(HGNC:HIF1A) increases bp(GO:"inflammatory response") - pmid:27288790 + pubmed:31346362 - a(CHEBI:"hydrogen peroxide") increases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:HIF1A) increases bp(GO:"inflammatory response") - pmid:14556719 + pubmed:31346362 - a(CHEBI:"hydrogen peroxide") increases bp(GO:"response to unfolded protein") + p(HGNC:HIF1A) increases bp(GO:"cell death") - pmid:23531502 + pubmed:31346362 - act(a(CHEBI:"hydrogen peroxide")) increases a(HBP:"Tau aggregates") + p(HGNC:HIF1A) increases g(HGNC:VEGFA) - pmid:23722080 + pubmed:31346362 - a(CHEBI:"hydrogen peroxide") increases bp(MESH:"Oxidative Stress") + p(HGNC:HIF1A) increases bp(GO:angiogenesis) - pmid:23722080 + pubmed:31346362 - a(CHEBI:"hydrogen peroxide") positiveCorrelation composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) + p(HGNC:HIF1A) increases g(HGNC:SLC2A1) - pmid:27288790 + pubmed:31346362 - p(HGNC:IL18) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:HIF1A) increases g(HGNC:HK2) - pmid:24561250 + pubmed:31346362 - p(HGNC:IL18) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:HIF1A) increases bp(GO:"glycolytic process") - pmid:27314526 + pubmed:21861815 - p(HGNC:IL18) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:HIF1A) increases bp(GO:"glycolytic process") - pmid:27314526 + pubmed:31346362 - p(HGNC:IL18) association path(MESH:"Alzheimer Disease") + p(HGNC:HIF1A) increases g(HGNCGENEFAMILY:"Toll like receptors") - pmid:27288790 + pubmed:31346362 - p(HGNC:IL18) increases act(p(FPLX:NFkappaB)) + p(HGNC:HIF1A) increases a(MESH:Alarmins) - pmid:24561250 + pubmed:31346362 - p(HGNC:IL18) positiveCorrelation complex(GO:"inflammasome complex") + p(HGNC:HIF1A) increases a(MESH:Cytokines) - pmid:24561250 + pubmed:31346362 - p(HGNC:IL18) increases bp(GO:"inflammatory response") + p(HGNC:HIF1A) increases p(MESH:"Matrix Metalloproteinases") - pmid:27314526 + pubmed:31346362 - p(HGNC:IL18) positiveCorrelation path(MESH:Dementia) + p(HGNC:HIF1A) increases bp(GO:autophagy) - pmid:27314526 + pubmed:31346362 - p(HGNC:IL18) increases bp(GO:"microglial cell activation") + p(HGNC:HIF1A) increases g(HGNC:TERT) - pmid:27314526 + pubmed:31346362 - p(HGNC:IL18) increases bp(GO:"astrocyte activation") + p(HGNC:HIF1A) increases g(HGNC:TGFB1) - pmid:27314526 + pubmed:31346362 - p(HGNC:IL18) increases a(CHEBI:"amyloid-beta") + p(HGNC:HIF1A) increases p(CONSO:"amyloid-beta fibrils") + + - pmid:27314526 + pubmed:21861815 - p(HGNC:IL18) increases p(HGNC:GSK3B) + p(HGNC:HIF1A) regulates act(p(MESH:"Hypoxia-Inducible Factor 1")) + + - pmid:27314526 + pubmed:21861815 - p(HGNC:IL18) increases p(HGNC:CDK5) + p(HGNC:HIF1A, loc(GO:nucleus)) increases complex(p(HGNC:ARNT), p(HGNC:HIF1A), loc(GO:nucleus)) + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - pmid:27288790 + pubmed:21861815 - p(HGNC:CXCL10) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:HIF1A) increases bp(GO:"pentose-phosphate shunt") - pmid:27288790 + pubmed:21861815 - p(HGNC:TGFB1) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:HIF1A) increases p(HGNC:SLC2A1) - pmid:26304819 + pubmed:21861815 - p(HGNC:TGFB1) biomarkerFor path(MESH:"Alzheimer Disease") + p(HGNC:HIF1A) increases p(HGNC:SLC2A3) - pmid:21718217 + pubmed:21861815 - p(HGNC:TGFB1) decreases a(MESH:Macrophages) + p(HGNC:HIF1A) decreases path(DOID:"Alzheimer's disease") - pmid:27288790 + pubmed:21861815 - bp(GO:"protein kinase B signaling") increases act(p(FPLX:NFkappaB)) + p(HGNC:HIF1A) increases r(HGNC:TH) - pmid:30061532 + pubmed:31346362 - bp(GO:"protein kinase B signaling") association path(MESH:Schizophrenia) + p(HGNCGENEFAMILY:"NF-kappa B complex subunits") increases bp(GO:"inflammatory response") - pmid:30061532 + pubmed:31346362 - bp(GO:"protein kinase B signaling") association path(MESH:Schizophrenia) + act(p(HGNCGENEFAMILY:"NF-kappa B complex subunits")) increases bp(GO:"inflammatory response") - pmid:30061532 + pubmed:30027901 - bp(GO:"protein kinase B signaling") association p(HGNC:NRG1) + p(HGNCGENEFAMILY:"NF-kappa B complex subunits") regulates bp(GO:"inflammatory response") - pmid:14556719 + pubmed:31346362 - bp(GO:"neuron apoptotic process") positiveCorrelation p(HGNC:CCNE1) + p(HGNCGENEFAMILY:"NF-kappa B complex subunits") increases bp(GO:"cell death") - pmid:29311797 + pubmed:31346362 - bp(GO:"neuron apoptotic process") decreases bp(GO:cognition) + act(p(HGNCGENEFAMILY:"NF-kappa B complex subunits")) increases bp(GO:"cellular respiration") - pmid:14963027 + pubmed:31346362 - bp(GO:"neuron apoptotic process") negativeCorrelation p(HGNC:HSPB1) + act(p(HGNCGENEFAMILY:"NF-kappa B complex subunits")) increases bp(GO:"programmed cell death") - pmid:27068745 + pubmed:31346362 - bp(GO:"neuron apoptotic process") positiveCorrelation p(HGNC:UNC5C) + act(p(HGNCGENEFAMILY:"NF-kappa B complex subunits")) increases bp(GO:phagocytosis) - pmid:27288790 + pubmed:31346362 - bp(GO:"MAPK cascade") positiveCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNCGENEFAMILY:"NF-kappa B complex subunits")) increases a(CHEBI:"reactive oxygen species") + + - pmid:27288790 + pubmed:30027901 - bp(GO:"MAPK cascade") increases p(FPLX:IKB, pmod(Ph)) + p(HGNCGENEFAMILY:"NF-kappa B complex subunits") association path(MESH:"Huntington Disease") - pmid:21214928 + pubmed:31346362 - bp(GO:"MAPK cascade") association a(CHEBI:"amyloid-beta") + a(CHEBI:dioxygen) increases bp(GO:"ATP biosynthetic process") - pmid:19293145 + pubmed:31346362 - bp(GO:"MAPK cascade") increases a(CHEBI:"amyloid-beta") + a(CHEBI:dioxygen) increases bp(GO:"energy homeostasis") - pmid:19126755 + pubmed:31346362 - bp(GO:"MAPK cascade") increases act(p(HBP:"alpha-4 beta-2 nAChR")) + a(CHEBI:dioxygen) increases bp(GO:"establishment or maintenance of transmembrane electrochemical gradient") - pmid:19126755 + pubmed:31346362 - bp(GO:"MAPK cascade") regulates r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + a(CHEBI:dioxygen) regulates bp(GO:"cellular calcium ion homeostasis") + + + + - pmid:19293145 + pubmed:30515821 - bp(GO:"MAPK cascade") increases act(p(HGNC:BAD)) + bp(GO:"ATP biosynthetic process") negativeCorrelation act(p(HGNC:DNM1L)) - pmid:19293145 + pubmed:30837838 - bp(GO:"MAPK cascade") increases act(p(HGNC:MYC)) + bp(GO:"ATP biosynthetic process") association bp(GO:"neuron fate commitment") - pmid:19293145 + pubmed:30837838 - bp(GO:"MAPK cascade") increases act(p(HGNC:MYC)) + bp(GO:"ATP biosynthetic process") association path(MESH:"Nerve Degeneration") - pmid:19293145 + pubmed:30515821 - bp(GO:"MAPK cascade") increases act(p(FPLX:NFkappaB)) + bp(GO:"energy homeostasis") decreases path(DOID:"neurodegenerative disease") - pmid:19293145 + pubmed:19126755 - bp(GO:"MAPK cascade") increases act(p(HGNC:NOS1)) + bp(GO:"energy homeostasis") regulates a(CHEBI:"kynurenic acid") - pmid:24590577 + pubmed:30027901 - bp(GO:"MAPK cascade") increases p(HGNC:BACE1) + bp(GO:"energy homeostasis") decreases tloc(a(CHEBI:"D-glutamate residue"), fromLoc(GO:cytoplasm), toLoc(GO:"extracellular space")) - pmid:27288790 + pubmed:30027901 - bp(GO:"ERK1 and ERK2 cascade") increases act(p(FPLX:NFkappaB)) + bp(GO:"energy homeostasis") decreases path(CONSO:Excitotoxicity) - pmid:21214928 + pubmed:21861815 - bp(GO:"ERK1 and ERK2 cascade") association a(CHEBI:"amyloid-beta") + bp(GO:"energy homeostasis") negativeCorrelation path(DOID:hypoglycemia) - pmid:19126755 + pubmed:21861815 - bp(GO:"ERK1 and ERK2 cascade") increases act(a(CHEBI:nicotine)) + bp(GO:"energy homeostasis") negativeCorrelation path(EFO:hypoxia) - pmid:19293145 + pubmed:21861815 - bp(GO:"ERK1 and ERK2 cascade") increases bp(GO:"apoptotic process") + bp(GO:"energy homeostasis") decreases bp(GO:"neuron death") - pmid:24590577 + pubmed:21871088 - bp(GO:"ERK1 and ERK2 cascade") regulates act(p(HGNC:ADAM10)) + bp(GO:"cellular calcium ion homeostasis") association bp(GO:"long-term synaptic depression") - pmid:24590577 + pubmed:21871088 - bp(GO:"ERK1 and ERK2 cascade") regulates bp(HBP:"APP processing") + bp(GO:"cellular calcium ion homeostasis") association bp(GO:"long-term synaptic potentiation") - pmid:27594586 + pubmed:31346362 - bp(GO:"ERK1 and ERK2 cascade") regulates p(HGNC:MMP9) + bp(GO:"membrane lipid catabolic process") increases deg(a(MESH:Cytoskeleton)) - pmid:27288790 + pubmed:23454242 - a(CHEBI:"SB-239063") decreases act(p(HGNC:MAPK14)) + a(MESH:Cytoskeleton) association p(HGNC:PPP2R2C) - pmid:27288790 + pubmed:22299660 - a(CHEBI:"anthra[1,9-cd]pyrazol-6(2H)-one") decreases p(FPLX:JNK) + a(MESH:Cytoskeleton) association p(FPLX:PPP2) - pmid:27288790 + pubmed:31346362 - a(CHEBI:"anthra[1,9-cd]pyrazol-6(2H)-one") increases act(p(HGNC:MAPK14)) + act(p(HGNCGENEFAMILY:Calpains)) increases bp(GO:"cell death") - pmid:27288790 + pubmed:27889190 - a(CHEBI:"advanced glycation end-product") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + act(p(HGNCGENEFAMILY:Calpains)) decreases a(GO:cytoskeleton) - pmid:24183963 + pubmed:29428175 - a(CHEBI:"advanced glycation end-product") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + p(HGNCGENEFAMILY:Calpains) increases p(GO:spectrin) - pmid:27288790 + pubmed:23516100 - a(CHEBI:"advanced glycation end-product") decreases bp(GO:memory) + act(p(HGNCGENEFAMILY:Calpains)) increases p(HGNC:HTT, frag("?")) - pmid:27288790 + pubmed:23516100 - a(CHEBI:"advanced glycation end-product") increases bp(GO:"cellular protein catabolic process") + act(p(HGNCGENEFAMILY:Calpains)) increases p(HGNC:HTT, frag("?")) - pmid:27288790 + pubmed:23516100 - a(CHEBI:"advanced glycation end-product") decreases bp(GO:"long-term synaptic potentiation") + p(HGNCGENEFAMILY:Calpains) regulates bp(GO:"calcium ion homeostasis") - pmid:24183963 + pubmed:23516100 - a(CHEBI:"advanced glycation end-product") directlyIncreases act(p(HGNC:AGER)) + p(HGNCGENEFAMILY:Calpains) regulates bp(GO:"regulation of synaptic plasticity") - pmid:8063802 + pubmed:23516100 - a(CHEBI:"advanced glycation end-product") increases act(p(HGNC:AGER)) + p(HGNCGENEFAMILY:Calpains) regulates bp(GO:"programmed cell death") - pmid:26095350 + pubmed:23516100 - a(CHEBI:"advanced glycation end-product") increases p(MGI:Mapt, pmod(Ph, Ser, 214)) + p(HGNCGENEFAMILY:Calpains) regulates bp(GO:"nervous system development") - pmid:26095350 + pubmed:23516100 - a(CHEBI:"advanced glycation end-product") increases p(MGI:Mapt, pmod(Ph, Ser, 396)) + act(p(HGNCGENEFAMILY:Calpains)) negativeCorrelation bp(GO:"cytoskeleton organization") - pmid:26095350 + pubmed:23516100 - a(CHEBI:"advanced glycation end-product") increases p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) + act(p(HGNCGENEFAMILY:Calpains)) positiveCorrelation path(DOID:"Alzheimer's disease") - pmid:8063802 + pubmed:23516100 - a(CHEBI:"advanced glycation end-product") decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + act(p(HGNCGENEFAMILY:Calpains)) increases p(HGNC:MAPT, frag("1_?")) - pmid:8063802 + pubmed:23516100 - a(CHEBI:"advanced glycation end-product") increases a(HBP:"Tau aggregates") + act(p(HGNCGENEFAMILY:Calpains)) causesNoChange p(CONSO:"paired helical filaments") - pmid:18930136 + pubmed:23516100 - bp(GO:"cellular protein catabolic process") regulates bp(GO:"cellular homeostasis") + act(p(HGNCGENEFAMILY:Calpains)) causesNoChange p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:18930136 + pubmed:23516100 - bp(GO:"cellular protein catabolic process") negativeCorrelation path(MESH:Neoplasms) + act(p(HGNCGENEFAMILY:Calpains)) association p(HGNC:BACE1) - pmid:18930136 + pubmed:23516100 - bp(GO:"cellular protein catabolic process") negativeCorrelation path(HBP:Neurodegeneration) + act(p(HGNCGENEFAMILY:Calpains)) increases a(CHEBI:"amyloid-beta polypeptide 40") - pmid:25036637 + pubmed:23516100 - bp(GO:"cellular protein catabolic process") association p(HGNC:DCP1A) + act(p(HGNCGENEFAMILY:Calpains)) increases a(CHEBI:"amyloid-beta polypeptide 42") + + - pmid:25036637 + pubmed:23516100 - bp(GO:"cellular protein catabolic process") association p(HGNC:EDC3) + act(p(HGNCGENEFAMILY:Calpains)) increases p(HGNC:SNCA, frag("?")) - pmid:25036637 + pubmed:30985105 - bp(GO:"cellular protein catabolic process") association p(HGNC:DDX6) + p(HGNCGENEFAMILY:Calpains) increases p(HGNC:SNCA, frag("?")) - pmid:27671637 + pubmed:30985105 - bp(GO:"cellular protein catabolic process") negativeCorrelation composite(a(HP:"Argyrophilic inclusion bodies"), p(MGI:Mapt)) + act(p(HGNCGENEFAMILY:Calpains)) increases p(HGNC:SNCA, frag("?")) - pmid:27288790 + pubmed:23516100 - a(CHEBI:pentosidine) isA a(CHEBI:"advanced glycation end-product") + act(p(HGNCGENEFAMILY:Calpains)) increases p(HGNC:ATXN3, frag("?")) - pmid:27288790 + pubmed:24027553 - a(CHEBI:pentosidine) positiveCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNCGENEFAMILY:Calpains)) increases deg(p(HGNC:MAPT)) - pmid:27288790 + pubmed:24027553 - a(HBP:GLAP) isA a(CHEBI:"advanced glycation end-product") + act(p(HGNCGENEFAMILY:Calpains)) increases deg(p(HGNC:MAPT)) - pmid:27288790 + pubmed:24027553 - a(HBP:GLAP) positiveCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNCGENEFAMILY:Calpains)) increases deg(p(HGNC:MAPT)) - + + + pubmed:24027553 + + p(HGNCGENEFAMILY:Calpains) association path(MESH:"Neurodegenerative Diseases") + - pmid:27288790 + pubmed:24027553 - complex(a(CHEBI:pentosidine), p(HGNC:AGER)) increases p(HGNC:BACE1) + act(p(HGNCGENEFAMILY:Calpains)) increases p(HGNC:MAPT, frag("?", "35kD")) - pmid:27288790 + pubmed:24027553 - complex(a(CHEBI:pentosidine), p(HGNC:AGER)) increases act(p(FPLX:NFkappaB)) + act(p(HGNCGENEFAMILY:Calpains)) increases p(HGNC:MAPT, frag("?", "17kD")) - pmid:27288790 + pubmed:24027553 - act(p(HGNC:AGER)) increases bp(GO:"MAPK cascade") + act(p(HGNCGENEFAMILY:Calpains)) increases p(HGNC:MAPT, frag("?", "17kD")) - pmid:26195256 + pubmed:24027553 - p(HGNC:AGER) increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:"Cardiovascular System"), toLoc(MESH:"Extracellular Space")) + act(p(HGNCGENEFAMILY:Calpains)) association path(CONSO:Excitotoxicity) - pmid:29626319 + pubmed:24027553 - p(HGNC:AGER) increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + act(p(HGNCGENEFAMILY:Calpains)) increases path(CONSO:Neurodegeneration) - pmid:26195256 + pubmed:30985105 - p(HGNC:AGER) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNCGENEFAMILY:Calpains) increases p(CONSO:"alpha-synuclein fibrils", frag("?")) - pmid:18494933 + pubmed:30985105 - act(p(HGNC:AGER)) positiveCorrelation p(FPLX:JNK) + act(p(HGNCGENEFAMILY:Calpains)) association path(MESH:"Parkinson Disease") - pmid:25681682 + pubmed:30985105 - p(HGNC:AGER) negativeCorrelation bp(GO:aging) + act(p(HGNCGENEFAMILY:Calpains)) association path(MESH:"Parkinson Disease") - pmid:25681682 + pubmed:30985105 - p(HGNC:AGER) negativeCorrelation bp(MESH:"Body Mass Index") + p(HGNCGENEFAMILY:Calpains) causesNoChange deg(p(HGNC:SNCA, pmod(CONSO:O-GlcNAcylation, Thr, 72))) - pmid:25681682 + pubmed:30985105 - p(HGNC:AGER) association act(p(HGNC:AGER)) + p(HGNCGENEFAMILY:Calpains) causesNoChange deg(p(HGNC:SNCA, pmod(CONSO:O-GlcNAcylation, Ser, 87))) - pmid:25681682 + pubmed:30985105 - act(p(HGNC:AGER)) association p(HGNC:AGER) + p(HGNCGENEFAMILY:Calpains) increases deg(p(HGNC:SNCA)) - pmid:24183963 + pubmed:31346362 - act(p(HGNC:AGER)) increases act(p(HGNC:GSK3B), ma(kin)) + act(p(MESH:Deoxyribonucleases)) increases bp(GO:"cell death") - + + + pubmed:31346362 + + g(HGNC:VEGFA) increases bp(GO:angiogenesis) + - pmid:27288790 + pubmed:27190210 - complex(a(HBP:GLAP), p(HGNC:AGER)) increases p(HGNC:BACE1) + bp(GO:angiogenesis) association p(HGNC:CHRNA7) - pmid:27288790 + pubmed:31346362 - complex(a(HBP:GLAP), p(HGNC:AGER)) increases act(p(FPLX:NFkappaB)) + p(HGNC:SLC2A1) increases bp(GO:"glycolytic process") - pmid:27288790 + pubmed:21861815 - p(HGNC:GSK3B) increases p(HGNC:BACE1) + p(HGNC:SLC2A1) regulates bp(GO:"glucose import") - - - pmid:30444369 + pubmed:29626319 - act(p(HGNC:GSK3B)) increases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:SLC2A1) increases p(HGNC:LRP1) - pmid:12428809 + pubmed:29626319 - p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:SLC2A1) regulates deg(a(CHEBI:amyloid-beta)) - pmid:29758300 + pubmed:29626319 - p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:SLC2A1) regulates tloc(a(CHEBI:amyloid-beta), fromLoc(MESH:Brain), toLoc(MESH:Blood)) - pmid:21882945 + pubmed:29626319 - act(p(HGNC:GSK3B)) directlyIncreases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:SLC2A1) regulates tloc(a(CHEBI:glucose), fromLoc(GO:"extracellular region"), toLoc(MESH:"Blood-Brain Barrier")) - pmid:29191965 + pubmed:29626319 - p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:SLC2A1) regulates a(MESH:"Blood-Brain Barrier") - pmid:29311797 + pubmed:31346362 - act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:HK2) increases bp(GO:"glycolytic process") - pmid:12551948 + pubmed:31346362 - act(p(HGNC:GSK3B)) increases p(HGNC:MAPT, pmod(Ph)) + a(MESH:Alarmins) increases bp(GO:"inflammatory response") + + + + + + + + + + - pmid:10998059 + pubmed:24561250 - act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph)) + a(MESH:Alarmins) increases complex(GO:"inflammasome complex") - pmid:27314526 + pubmed:24561250 - p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph)) + a(MESH:Alarmins) increases act(complex(GO:"inflammasome complex")) - pmid:22122372 + pubmed:31346362 - p(HGNC:GSK3B) increases p(HBP:HBP00071, pmod(Ph, Thr, 654)) + a(MESH:Cytokines) increases bp(GO:"inflammatory response") - pmid:22122372 + pubmed:30967783 - p(HGNC:GSK3B) increases p(HBP:HBP00071, pmod(Ph, Thr, 668)) + a(MESH:Cytokines) decreases bp(GO:"inflammatory response") - pmid:22122372 + pubmed:27288790 - p(HGNC:GSK3B) increases p(HBP:HBP00071, pmod(Ph, Ser, 665)) + a(MESH:Cytokines) increases act(p(FPLX:"IKK_complex")) - DOI:10.4172/2168-975X.1000126 + pubmed:27288790 - p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + a(MESH:Cytokines) directlyIncreases m(MIRBASE:hsa-mir-155) - pmid:25331948 + pubmed:26551702 - p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + a(MESH:Cytokines) positiveCorrelation p(HGNC:NFE2L2) - pmid:14612456 + pubmed:26551702 - p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + a(MESH:Cytokines) increases path(MESH:Gliosis) - pmid:17078951 + pubmed:26551702 - act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + a(MESH:Cytokines) increases bp(GO:"neuron death") - pmid:19459590 + pubmed:26551702 - act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + a(MESH:Cytokines) decreases bp(GO:myelination) - pmid:29844403 + pubmed:26551702 - act(p(HGNC:GSK3B)) decreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + a(MESH:Cytokines) increases act(p(HGNC:BTRC)) - DOI:10.4172/2168-975X.1000126 + pubmed:30988501 - p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + a(MESH:Cytokines) increases path(MESH:Inflammation) - pmid:25331948 + pubmed:30967783 - p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + a(MESH:Cytokines) increases path(MESH:Inflammation) - pmid:14612456 + pubmed:27190210 - p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + tloc(a(MESH:Cytokines), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) increases path(MESH:Inflammation) - pmid:17078951 + pubmed:30967783 - act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + a(MESH:Cytokines) increases a(MESH:"Leukocytes, Mononuclear", loc(NCIT:C74601)) - pmid:19459590 + pubmed:30967783 - act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + a(MESH:Cytokines) increases deg(a(MESH:Tissues)) - DOI:10.4172/2168-975X.1000126 + pubmed:23092889 - p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) + a(MESH:Cytokines) increases bp(GO:pyroptosis) - pmid:17078951 + pubmed:26979166 - act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) + a(MESH:Cytokines) increases deg(a(MESH:"White Matter")) - DOI:10.4172/2168-975X.1000126 + pubmed:26979166 - p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) + a(MESH:Cytokines) increases deg(a(MESH:"Gray Matter")) - pmid:25331948 + pubmed:30988501 - p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) + a(MESH:Cytokines) increases a(CHEBI:"reactive oxygen species") - pmid:14612456 + pubmed:30988501 - p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) + a(MESH:Cytokines) decreases bp(GO:"monoamine transport") - pmid:17078951 + pubmed:30988501 - act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) + a(MESH:Cytokines) increases bp(GO:"synaptic transmission, glutamatergic") - pmid:19459590 + pubmed:31346362 - act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) + p(MESH:"Matrix Metalloproteinases") increases bp(GO:"inflammatory response") - - - pmid:24653673 + pubmed:26445701 - p(HGNC:GSK3B) association path(MESH:"Alzheimer Disease") + p(MESH:"Matrix Metalloproteinases") increases bp(MESH:"Transendothelial and Transepithelial Migration") - pmid:24653673 + pubmed:26445701 - act(p(HGNC:GSK3B)) negativeCorrelation a(GO:"microtubule cytoskeleton") + p(MESH:"Matrix Metalloproteinases") increases path(HP:"CNS demyelination") - pmid:24653673 + pubmed:26445701 - act(p(HGNC:GSK3B)) negativeCorrelation a(GO:"neurofilament cytoskeleton") + p(MESH:"Matrix Metalloproteinases") increases path(MESH:"Diffuse Axonal Injury") - pmid:24653673 + pubmed:26445701 - act(p(HGNC:GSK3B)) negativeCorrelation p(HGNC:APP, pmod(Ph)) + p(MESH:"Matrix Metalloproteinases") increases bp(GO:"positive regulation of oligodendrocyte apoptotic process") - pmid:24653673 + pubmed:31346362 - act(p(HGNC:GSK3B)) negativeCorrelation bp(HBP:"APP processing") + bp(GO:"necrotic cell death") increases a(MESH:Alarmins) - pmid:24653673 + pubmed:31346362 - act(p(HGNC:GSK3B)) negativeCorrelation bp(GO:neurogenesis) + p(HGNC:HMGB1) increases a(MESH:Alarmins) - pmid:24653673 + pubmed:23092889 - act(p(HGNC:GSK3B)) positiveCorrelation bp(GO:"negative regulation of synaptic plasticity") + p(HGNC:HMGB1) increases bp(GO:pyroptosis) - pmid:24653673 + pubmed:26979166 - act(p(HGNC:GSK3B)) positiveCorrelation bp(GO:"apoptotic process") + tloc(p(HGNC:HMGB1), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) increases path(MESH:Inflammation) - pmid:24653673 + pubmed:31346362 - act(p(HGNC:GSK3B)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + bp(GO:"ATP generation from ADP") increases a(MESH:Alarmins) - pmid:24653673 + pubmed:31346362 - act(p(HGNC:GSK3B)) increases p(FPLX:PPP2, pmod(Ph, Tyr, 307)) + p(NCIT:C706) increases a(MESH:Alarmins) - pmid:24653673 + pubmed:31346362 - act(p(HGNC:GSK3B)) decreases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) + complex(a(MESH:Alarmins), p(HGNC:AGER)) increases act(p(HGNCGENEFAMILY:"NF-kappa B complex subunits")) - pmid:24653673 + pubmed:31346362 - act(p(HGNC:GSK3B)) decreases p(HGNC:PPP2CB, pmod(Me, Leu, 309)) + complex(a(MESH:Alarmins), p(HGNC:AGER)) increases act(p(HGNC:STAT3)) - pmid:24653673 + pubmed:31346362 - act(p(HGNC:GSK3B)) decreases act(p(HGNC:LCMT1)) + complex(a(MESH:Alarmins), p(HGNC:AGER)) increases act(complex(GO:"transcription factor AP-1 complex")) + + + + + + - pmid:24653673 + pubmed:27288790 - act(p(HGNC:GSK3B)) increases act(p(HGNC:PPME1)) + act(p(HGNC:AGER)) increases bp(GO:"MAPK cascade") - pmid:24653673 + pubmed:26195256 - act(p(HGNC:GSK3B)) increases p(HGNC:SET) + p(HGNC:AGER) increases tloc(a(CHEBI:amyloid-beta), fromLoc(MESH:"Cardiovascular System"), toLoc(MESH:"Extracellular Space")) - pmid:12428809 + pubmed:29626319 - p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + p(HGNC:AGER) increases tloc(a(CHEBI:amyloid-beta), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:18494933 + pubmed:26195256 - act(p(HGNC:GSK3B)) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + p(HGNC:AGER) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:24183963 + pubmed:18494933 - act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + act(p(HGNC:AGER)) positiveCorrelation p(FPLX:JNK, pmod(go:0006468 ! "protein phosphorylation")) - pmid:18494933 + pubmed:25681682 - act(p(HGNC:GSK3B), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + p(HGNC:AGER) negativeCorrelation bp(GO:aging) - pmid:12428809 + pubmed:25681682 - p(HGNC:GSK3B) decreases complex(a(MESH:Microtubules), p(HGNC:MAPT)) + p(HGNC:AGER) negativeCorrelation bp(MESH:"Body Mass Index") - pmid:12428809 + pubmed:25681682 - p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) + act(p(HGNC:AGER)) association p(HGNC:AGER) - pmid:12428809 + pubmed:25681682 - p(HGNC:GSK3B) increases a(MESH:Axons) + p(HGNC:AGER) association act(p(HGNC:AGER)) - pmid:12428809 + pubmed:24183963 - p(HGNC:GSK3B) association bp(GO:"axonal transport") + act(p(HGNC:AGER)) increases act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) + + - pmid:21734277 + pubmed:25681350 - act(p(HGNC:GSK3B)) decreases bp(GO:"axonal transport") + p(HGNC:STAT3) causesNoChange p(HGNC:CHI3L1) - pmid:21882945 + pubmed:28745240 - p(HGNC:GSK3B) increases act(p(HGNC:MARK2)) + p(HGNC:STAT3) increases bp(GO:"astrocyte development") + + - pmid:22419736 + pubmed:19293145 - act(p(HGNC:GSK3B)) negativeCorrelation p(FPLX:AMPK) + act(p(HGNC:STAT3)) association p(HGNC:JAK2) - pmid:30640040 + pubmed:19293145 - p(HGNC:GSK3B) association a(PUBCHEM:71295844) + act(p(HGNC:STAT3)) association a(CHEBI:nicotine) + + + + - pmid:29191965 + pubmed:26979166 - p(HGNC:GSK3B) association path(MESH:Tauopathies) + act(p(HGNC:STAT3)) directlyIncreases act(p(MESH:"NF-kappa B")) + + - pmid:11812770 + pubmed:30116051 - p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, frag("1_244")) + p(HGNC:STAT3) decreases bp(GO:macroautophagy) - pmid:11812770 + pubmed:31346362 - p(HGNC:GSK3B) positiveCorrelation complex(p(HGNC:GSK3B), p(HGNC:MAPT)) + complex(a(MESH:Alarmins), p(HGNC:P2RX7)) increases act(p(HGNCGENEFAMILY:"NF-kappa B complex subunits")) - pmid:14612456 + pubmed:31346362 - p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, pmod(Ph, Thr, 205)) + complex(a(MESH:Alarmins), p(HGNC:P2RX7)) increases act(p(HGNC:STAT3)) - pmid:17078951 + pubmed:31346362 - act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Thr, 205)) + complex(a(MESH:Alarmins), p(HGNC:P2RX7)) increases act(complex(GO:"transcription factor AP-1 complex")) + + - pmid:19459590 + pubmed:24561250 - act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Thr, 205)) + p(HGNC:P2RX7) increases act(complex(GO:"NLRP1 inflammasome complex")) - pmid:18494933 + pubmed:24561250 - act(p(HGNC:GSK3B)) negativeCorrelation bp(GO:"Wnt signaling pathway") + p(HGNC:P2RX7) increases act(complex(GO:"NLRP1 inflammasome complex")) + + - pmid:12551948 + pubmed:27314526 - p(HGNC:GSK3B) association p(HGNC:YWHAZ) + act(p(HGNC:P2RX7)) increases bp(GO:"inflammatory response") - pmid:12551948 + pubmed:27314526 - p(HGNC:GSK3B) isA complex(p(HGNC:GSK3B), p(HGNC:MAPT), p(HGNC:YWHAZ)) + act(p(HGNC:P2RX7)) increases bp(GO:"apoptotic process") - pmid:23531502 + pubmed:27314526 - act(p(HGNC:GSK3B)) association a(HBP:"Tau aggregates") + act(p(HGNC:P2RX7)) increases bp(GO:"cell proliferation") - pmid:29121589 + pubmed:27314526 - p(HGNC:GSK3B) increases p(HGNC:NFE2L2, pmod(Ph)) + p(HGNC:P2RX7) increases act(complex(GO:"NLRP3 inflammasome complex")) - pmid:29121589 + pubmed:27314526 - act(p(HGNC:GSK3B)) negativeCorrelation p(HGNC:NFE2L2) + p(HGNC:P2RX7) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:24355211 + pubmed:31346362 - p(HGNC:GSK3B) decreases p(HGNC:NFE2L2) + complex(a(MESH:Alarmins), p(HGNCGENEFAMILY:"NLR family")) increases act(p(HGNCGENEFAMILY:"NF-kappa B complex subunits")) - pmid:7514173 + pubmed:31346362 - act(p(HGNC:GSK3B), ma(kin)) increases p(FPLX:CREB, pmod(Ph)) + complex(a(MESH:Alarmins), p(HGNCGENEFAMILY:"NLR family")) increases act(p(HGNC:STAT3)) - pmid:7514173 + pubmed:31346362 - act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MBP, pmod(Ph)) + complex(a(MESH:Alarmins), p(HGNCGENEFAMILY:"NLR family")) increases act(complex(GO:"transcription factor AP-1 complex")) + + - pmid:7514173 + pubmed:31346362 - act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:CSN3, pmod(Ph)) + complex(a(MESH:Alarmins), complex(GO:"inflammasome complex")) increases act(p(HGNCGENEFAMILY:"NF-kappa B complex subunits")) - pmid:7514173 + pubmed:31346362 - act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:PPP1R2, pmod(Ph)) + complex(a(MESH:Alarmins), complex(GO:"inflammasome complex")) increases act(p(HGNC:STAT3)) - pmid:7514173 + pubmed:31346362 - act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:CSNK2B, pmod(Ph)) + complex(a(MESH:Alarmins), complex(GO:"inflammasome complex")) increases act(complex(GO:"transcription factor AP-1 complex")) + + - pmid:17078951 + pubmed:31346362 - act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) + act(complex(GO:"inflammasome complex")) increases bp(GO:"inflammatory response") - pmid:17078951 + pubmed:31346362 - act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 199)) + act(complex(GO:"inflammasome complex")) increases a(CHEBI:"reactive oxygen species") - pmid:19459590 + pubmed:31346362 - act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 199)) + complex(GO:"inflammasome complex") positiveCorrelation a(CHEBI:"reactive oxygen species") - pmid:17078951 + pubmed:31346362 - act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Thr, 217)) + complex(GO:"inflammasome complex") positiveCorrelation path(NCIT:C82901) - pmid:17078951 + pubmed:23092889 - act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 422)) + act(complex(GO:"inflammasome complex")) increases p(HGNC:HMGB1) - pmid:17078951 + pubmed:23092889 - act(p(HGNC:GSK3B), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Thr, 212)) + act(complex(GO:"inflammasome complex")) increases p(HGNC:HMGB1) - pmid:9089387 + pubmed:23092889 - act(p(HGNC:GSK3B), ma(kin)) increases p(FPLX:PDH, pmod(Ph)) + act(complex(GO:"inflammasome complex")) increases a(MESH:Cytokines) - pmid:9089387 + pubmed:23092889 - p(HGNC:GSK3B) isA p(ECCODE:"2.7.11.26") + act(complex(GO:"inflammasome complex")) increases p(HGNC:IL1B) - pmid:26501932 + pubmed:23702978 - p(HGNC:GSK3B) partOf a(HBP:"GVD bodies") + complex(GO:"inflammasome complex") increases act(p(HGNC:IL1B)) - pmid:25331948 + pubmed:24561250 - act(p(HGNC:GSK3B), ma(kin)) increases p(HBP:"Tau epitope, PHF1") + complex(GO:"inflammasome complex") positiveCorrelation p(HGNC:IL1B) - pmid:28176663 + pubmed:24561250 - act(p(HGNC:GSK3B), ma(kin)) positiveCorrelation a(HBP:"Braak_Stage I") + complex(GO:"inflammasome complex") increases p(HGNC:IL1B) - pmid:28176663 + pubmed:24561250 - act(p(HGNC:GSK3B), ma(kin)) positiveCorrelation a(HBP:"Braak_Stage II") + complex(GO:"inflammasome complex") regulates p(HGNC:IL1B) - pmid:28176663 + pubmed:27314526 - act(p(HGNC:GSK3B), ma(kin)) negativeCorrelation a(HBP:"Braak_Stage V") + complex(GO:"inflammasome complex") increases act(p(HGNC:IL1B)) - pmid:24355211 + pubmed:23092889 - p(HGNC:GSK3B) positiveCorrelation bp(MESH:"Oxidative Stress") + act(complex(GO:"inflammasome complex")) increases p(HGNC:IL18) - pmid:24355211 + pubmed:23702978 - p(HGNC:GSK3B) negativeCorrelation bp(GO:learning) + complex(GO:"inflammasome complex") increases act(p(HGNC:IL18)) - pmid:24355211 + pubmed:24561250 - p(HGNC:GSK3B) negativeCorrelation bp(GO:memory) + complex(GO:"inflammasome complex") positiveCorrelation p(HGNC:IL18) - pmid:24355211 + pubmed:24561250 - act(p(HGNC:GSK3B), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 231)) + complex(GO:"inflammasome complex") increases p(HGNC:IL18) - pmid:24355211 + pubmed:24561250 - act(p(HGNC:GSK3B), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 235)) + act(complex(GO:"inflammasome complex")) increases p(HGNC:IL18) - pmid:25546293 + pubmed:24561250 - act(p(HGNC:GSK3B), ma(kin)) directlyIncreases p(HGNC:CTNNB1, pmod(Ph, Ser, 33)) + complex(GO:"inflammasome complex") regulates p(HGNC:IL18) - pmid:25546293 + pubmed:27314526 - act(p(HGNC:GSK3B), ma(kin)) directlyIncreases p(HGNC:CTNNB1, pmod(Ph, Ser, 37)) + complex(GO:"inflammasome complex") increases act(p(HGNC:IL18)) - pmid:25546293 + pubmed:23702978 - act(p(HGNC:GSK3B), ma(kin)) directlyIncreases p(HGNC:CTNNB1, pmod(Ph, Thr, 41)) + complex(GO:"inflammasome complex") increases act(p(HGNC:CASP1)) - pmid:27288790 + pubmed:23702978 - p(HGNC:GSK3A) causesNoChange p(HGNC:BACE1) + complex(GO:"inflammasome complex") increases act(p(HGNC:CASP1)) - pmid:30640040 + pubmed:24561250 - p(HGNC:GSK3A) association a(PUBCHEM:71295844) + act(complex(GO:"inflammasome complex")) increases act(p(HGNC:CASP1)) - pmid:22817713 + pubmed:27314526 - p(HGNC:GSK3A) decreases bp(GO:"anterograde axonal protein transport") + act(complex(GO:"inflammasome complex")) increases act(p(HGNC:CASP1)) - + + + pubmed:27314526 + + complex(GO:"inflammasome complex") increases act(p(HGNC:CASP1)) + - pmid:27288790 + pubmed:23702978 - composite(p(HGNC:GSK3B), p(HGNC:RELA)) increases r(HGNC:BACE1) + act(complex(GO:"inflammasome complex")) increases bp(GO:pyroptosis) - pmid:27288790 + pubmed:23702978 - p(HGNC:UCHL1) decreases p(HGNC:BACE1) + complex(GO:"inflammasome complex") increases bp(GO:pyroptosis) - pmid:27288790 + pubmed:27314526 - act(p(HGNC:UCHL1)) decreases p(HGNC:BACE1) + complex(GO:"inflammasome complex") increases bp(GO:pyroptosis) - - - pmid:21722302 + pubmed:23702978 - p(HGNC:UCHL1) association bp(GO:"chaperone-mediated autophagy") + complex(GO:"inflammasome complex") increases act(p(HGNC:SCAF11)) + + + + - pmid:14556719 + pubmed:27314526 - p(HGNC:UCHL1) decreases bp(GO:"protein ubiquitination") + complex(GO:"inflammasome complex") increases act(p(HGNC:IL33)) - pmid:14556719 + pubmed:27314526 - p(HGNC:UCHL1) increases p(HGNC:SNCA, pmod(Ub)) + complex(GO:"inflammasome complex") association path(MESH:"Alzheimer Disease") - pmid:14556719 + pubmed:31346362 - p(HGNC:UCHL1) decreases path(MESH:"Deglutition Disorders") + p(HGNC:INSRR) increases bp(GO:"cellular respiration") - pmid:14556719 + pubmed:31346362 - p(HGNC:UCHL1) positiveCorrelation a(MESH:"Solitary Nucleus") + p(HGNC:INSRR) increases bp(GO:"cytokine production") - pmid:14556719 + pubmed:31346362 - p(HGNC:UCHL1) positiveCorrelation a(MESH:"Area Postrema") + p(HGNC:INSRR) increases path(MESH:Inflammation) - pmid:22908190 + pubmed:31346362 - p(HGNC:UCHL1) association path(MESH:"Parkinson Disease") + act(p(HGNC:INSRR)) increases bp(GO:"cell death") - pmid:22908190 + pubmed:31346362 - p(HGNC:UCHL1) association path(MESH:"Alzheimer Disease") + act(p(HGNC:INSRR)) increases deg(a(MESH:Tissues)) - - - pmid:22908190 + pubmed:31346362 - p(HGNC:UCHL1) increases act(a(GO:synapse)) + act(p(HGNC:INSRR)) increases path(MESH:Fibrosis) - pmid:22908190 + pubmed:31346362 - p(HGNC:UCHL1) increases bp(GO:memory) + act(p(HGNC:INSRR)) increases deg(a(MESH:Neurons)) - pmid:27288790 + pubmed:31346362 - a(MESH:Lipopolysaccharides) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) + act(p(HGNC:INSRR)) increases path(DOID:amyloidosis) - pmid:27288790 + pubmed:30988501 - a(MESH:Lipopolysaccharides) increases p(HGNC:TNF) + bp(GO:"cytokine production") increases bp(MESH:"Immunity, Innate") - pmid:27288790 + pubmed:31346362 - a(MESH:Lipopolysaccharides) increases sec(p(HGNC:TNF)) + deg(a(MESH:Tissues)) increases path(MESH:Fibrosis) - pmid:27288790 + pubmed:27299292 - a(MESH:Lipopolysaccharides) increases p(HGNC:IL1B) + path(MESH:Fibrosis) negativeCorrelation p(HGNC:TFEB) - pmid:27288790 + pubmed:26195256 - a(MESH:Lipopolysaccharides) increases sec(p(HGNC:IL1B)) + path(MESH:Fibrosis) decreases a(MESH:"Cerebrospinal Fluid") - pmid:27288790 + pubmed:27889190 - m(MIRBASE:"hsa-mir-125b-1") decreases p(HGNC:ALOX15) + a(MESH:Neurons) increases p(HGNC:LINGO1) - pmid:27288790 + pubmed:27889190 - m(MIRBASE:"hsa-mir-125b-1") decreases p(HGNC:VDR) + a(MESH:Neurons) increases bp(MESH:Remyelination) + + - pmid:25001178 + pubmed:30967783 - m(MIRBASE:"hsa-mir-125b-1") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + act(a(MESH:Neurons)) positiveCorrelation a(MESH:Astrocytes) - pmid:25001178 + pubmed:30967783 - m(MIRBASE:"hsa-mir-125b-1") increases act(p(HGNC:CDK5R1)) + act(a(MESH:Neurons)) negativeCorrelation bp(GO:"neuroinflammatory response") - pmid:25001178 + pubmed:16340157 - m(MIRBASE:"hsa-mir-125b-1") increases act(p(HGNC:CDK5), ma(kin)) + a(MESH:Neurons) negativeCorrelation a(NIFT:"Grey matter atrophy") - pmid:25001178 + pubmed:19126755 - m(MIRBASE:"hsa-mir-125b-1") increases act(p(HGNC:MAPK3), ma(kin)) + a(MESH:Neurons) increases deg(a(CHEBI:nicotine)) - pmid:25001178 + pubmed:19126755 - m(MIRBASE:"hsa-mir-125b-1") increases act(p(HGNC:MAPK1), ma(kin)) + a(MESH:Neurons) association p(HGNC:CHRNA7) - pmid:25001178 + pubmed:19126755 - m(MIRBASE:"hsa-mir-125b-1") decreases p(HGNC:PPP1CA) + a(MESH:Neurons) regulates a(CHEBI:"kynurenic acid") - pmid:25001178 + pubmed:21482353 - m(MIRBASE:"hsa-mir-125b-1") decreases p(HGNC:DUSP6) + a(MESH:Neurons) negativeCorrelation act(p(FPLX:CHRN)) - pmid:25001178 + pubmed:21482353 - m(MIRBASE:"hsa-mir-125b-1") decreases p(HGNC:DUSP6) + a(MESH:Neurons) increases tloc(a(CHEBI:"gamma-aminobutyric acid"), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) - pmid:25001178 + pubmed:28901280 - m(MIRBASE:"hsa-mir-125b-1") decreases p(HGNC:BCL2L2) + a(MESH:Neurons) association p(MESH:"Receptors, Nicotinic") - pmid:27288790 + pubmed:30108137 - m(MIRBASE:"hsa-mir-125b-2") decreases p(HGNC:ALOX15) + act(a(MESH:Neurons)) increases tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:27288790 + pubmed:24027553 - m(MIRBASE:"hsa-mir-125b-2") decreases p(HGNC:VDR) + act(a(MESH:Neurons)) negativeCorrelation p(HGNC:MAPT) - pmid:27288790 + pubmed:29238289 - m(MIRBASE:"hsa-mir-146a") positiveCorrelation path(MESH:"Alzheimer Disease") + act(a(MESH:Neurons)) increases tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:27288790 + pubmed:29238289 - m(MIRBASE:"hsa-mir-146a") association r(HGNC:IRAK1) + act(a(MESH:Neurons)) increases tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + - pmid:27288790 + pubmed:27671637 - m(MIRBASE:"hsa-mir-146a") association bp(GO:"immune response") + act(a(MESH:Neurons)) negativeCorrelation p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) - pmid:27288790 + pubmed:17954934 - m(MIRBASE:"hsa-mir-146a") increases path(HP:Neurodegeneration) + act(a(MESH:Neurons)) association p(HGNC:BAG1) - pmid:27288790 + pubmed:31346362 - m(MIRBASE:"hsa-mir-155") positiveCorrelation path(MESH:"Alzheimer Disease") + complex(a(CONSO:"amyloid-beta fibrils"), a(MESH:Alarmins), loc(GO:"extracellular region")) increases act(p(HGNCGENEFAMILY:"NF-kappa B complex subunits")) - pmid:27288790 + pubmed:31346362 - m(MIRBASE:"hsa-mir-155") positiveCorrelation path(MESH:"Multiple Sclerosis") + complex(a(CONSO:"amyloid-beta fibrils"), a(MESH:Alarmins), loc(GO:"extracellular region")) increases bp(GO:"cellular respiration") - pmid:27288790 + pubmed:31346362 - r(HGNC:IRAK1) association m(MIRBASE:"hsa-mir-146a") + complex(a(CONSO:"amyloid-beta fibrils"), a(MESH:Alarmins), loc(GO:"extracellular region")) increases bp(GO:"programmed cell death") - pmid:27288790 + pubmed:31346362 - path(MESH:"Multiple Sclerosis") positiveCorrelation m(MIRBASE:"hsa-mir-155") + complex(a(CONSO:"amyloid-beta fibrils"), a(MESH:Alarmins), loc(GO:"extracellular region")) increases bp(GO:phagocytosis) - pmid:27288790 + pubmed:31346362 - a(CHEBI:"(+)-Tetrandrine") decreases act(p(FPLX:NFkappaB)) + complex(a(CONSO:"amyloid-beta fibrils"), a(MESH:Alarmins), loc(GO:intracellular)) increases act(complex(GO:"inflammasome complex")) + + - pmid:27288790 + pubmed:19293145 - a(CHEBI:"(+)-Tetrandrine") decreases p(HGNC:NOS2) + a(CONSO:"amyloid-beta fibrils") isA a(CHEBI:amyloid-beta) - pmid:27288790 + pubmed:17403556 - a(CHEBI:"(+)-Tetrandrine") decreases p(HGNC:PTGS2) + a(CONSO:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:27288790 + pubmed:17403556 - a(MESH:Morphine) decreases act(p(FPLX:NFkappaB)) + a(CONSO:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) - pmid:27288790 + pubmed:17403556 - a(MESH:Morphine) increases p(FPLX:IKB) + a(CONSO:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) - pmid:27288790 + pubmed:17403556 - a(PUBCHEM:439378) decreases a(CHEBI:"amyloid-beta polypeptide 42") + a(CONSO:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) - pmid:27288790 + pubmed:17403556 - a(PUBCHEM:439378) decreases p(FPLX:ERK) + a(CONSO:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) - pmid:27288790 + pubmed:17403556 - a(PUBCHEM:439378) decreases p(HGNC:MAPK14) + a(CONSO:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 181)) - pmid:27288790 + pubmed:30515821 - a(PUBCHEM:439378) decreases p(FPLX:NFkappaB) + bp(GO:"programmed cell death") increases a(CHEBI:"reactive oxygen species") - pmid:27288790 + pubmed:27299292 - a(PUBCHEM:3968) decreases p(HGNC:NFKBIA, pmod(Ph, Tyr, 42)) + bp(GO:"programmed cell death") negativeCorrelation p(HGNC:TFEB) - pmid:27288790 + pubmed:18305152 - a(PUBCHEM:3968) decreases act(p(FPLX:NFkappaB)) + bp(GO:"programmed cell death") negativeCorrelation p(HGNC:TARDBP) - pmid:27288790 + pubmed:18305152 - a(CHEBI:melatonin) decreases p(HGNC:NFKBIA, pmod(Ph, Tyr, 42)) + bp(GO:"programmed cell death") negativeCorrelation p(HGNC:TARDBP) - pmid:27288790 + pubmed:31346362 - a(CHEBI:melatonin) decreases act(p(FPLX:NFkappaB)) + a(CHEBI:"reactive oxygen species") increases bp(GO:"cell death") - pmid:27288790 + pubmed:31346362 - a(CHEBI:naproxen) isA a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") + a(CHEBI:"reactive oxygen species") increases deg(a(MESH:Tissues)) - pmid:27288790 + pubmed:31346362 - a(CHEBI:naproxen) decreases r(HGNC:BACE1) + a(CHEBI:"reactive oxygen species") negativeCorrelation a(MESH:"Anti-Inflammatory Agents") - pmid:27288790 + pubmed:31346362 - a(CHEBI:naproxen) decreases a(CHEBI:"amyloid-beta") + a(CHEBI:"reactive oxygen species") positiveCorrelation complex(GO:"inflammasome complex") - pmid:27288790 + pubmed:28745240 - a(CHEBI:hydroxytyrosol) decreases act(p(FPLX:NFkappaB)) + a(CHEBI:"reactive oxygen species") increases act(complex(GO:"NF-kappaB complex")) - pmid:27288790 + pubmed:28745240 - a(CHEBI:nicorandil) decreases bp(GO:"apoptotic process") + a(CHEBI:"reactive oxygen species") increases bp(GO:neurogenesis) - pmid:27288790 + pubmed:29179999 - a(CHEBI:nicorandil) decreases path(MESH:"Oxidative Stress") + a(CHEBI:"reactive oxygen species") increases act(p(FPLX:PKC)) - pmid:27288790 + pubmed:29179999 - a(CHEBI:nicorandil) decreases p(HBP:APP695) + a(CHEBI:"reactive oxygen species") increases act(p(FPLX:ERK)) - pmid:27288790 + pubmed:29179999 - a(CHEBI:nicorandil) decreases a(CHEBI:"amyloid-beta polypeptide 42") + a(CHEBI:"reactive oxygen species") increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) - pmid:27288790 + pubmed:27288790 - a(PUBCHEM:6440944) decreases act(p(FPLX:ERK)) + a(CHEBI:"reactive oxygen species") increases act(p(FPLX:NFkappaB)) - pmid:27288790 + pubmed:27288790 - a(PUBCHEM:6440944) decreases p(HGNC:NFKBIA, pmod(Ph)) + a(CHEBI:"reactive oxygen species") regulates act(p(FPLX:NFkappaB)) - pmid:27288790 + pubmed:27288790 - a(PUBCHEM:6440944) decreases p(FPLX:NFkappaB, pmod(Ph)) + a(CHEBI:"reactive oxygen species") increases act(p(FPLX:"IKK_complex")) - pmid:27288790 + pubmed:27288790 - a(PUBCHEM:6440944) decreases act(p(FPLX:NFkappaB)) + a(CHEBI:"reactive oxygen species") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27288790 + pubmed:27288790 - a(PUBCHEM:6440944) decreases p(HGNC:MAPT, pmod(Ph)) + a(CHEBI:"reactive oxygen species") association bp(MESH:"Membrane Fluidity") - pmid:27288790 + pubmed:27288790 - a(PUBCHEM:6440944) decreases p(HGNC:APP) + a(CHEBI:"reactive oxygen species") association bp(GO:"ion transport") - pmid:27288790 + pubmed:27288790 - a(PUBCHEM:6440944) decreases a(CHEBI:"amyloid-beta") + a(CHEBI:"reactive oxygen species") increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:27288790 + pubmed:27288790 - a(PUBCHEM:6440944) decreases sec(a(CHEBI:"amyloid-beta")) + a(CHEBI:"reactive oxygen species") decreases bp(GO:autophagy) - - - - - - - pmid:25652642 + pubmed:24563850 - complex(a(GO:"NF-kappaB complex"), p(HGNC:NFKB1), p(HGNC:RELA)) increases act(complex(GO:"NF-kappaB p50/p65 complex")) + a(CHEBI:"reactive oxygen species") regulates bp(GO:autophagy) - pmid:25652642 + pubmed:23528736 - bp(GO:"membrane depolarization") increases act(complex(GO:"NF-kappaB complex")) + a(CHEBI:"reactive oxygen species") negativeCorrelation bp(GO:autophagy) - pmid:17009926 + pubmed:27288790 - bp(GO:"membrane depolarization") increases act(complex(GO:"voltage-gated calcium channel complex")) + a(CHEBI:"reactive oxygen species") increases p(HGNC:NFKBIA, pmod(go:0006468 ! "protein phosphorylation")) - pmid:26813123 + pubmed:26551702 - bp(GO:"membrane depolarization") regulates act(p(HGNC:CHAT)) + a(CHEBI:"reactive oxygen species") decreases complex(p(HGNC:KEAP1), p(HGNC:NFE2L2)) - pmid:26813123 + pubmed:30962309 - bp(GO:"membrane depolarization") increases tloc(a(CHEBI:acetylcholine), fromLoc(MESH:"Synaptic Vesicles"), toLoc(GO:"synaptic cleft")) + a(CHEBI:"reactive oxygen species") increases p(HGNC:TXNIP) - pmid:26813123 + pubmed:30962309 - bp(GO:"membrane depolarization") increases complex(a(GO:"plasma membrane"), p(HGNC:SLC5A7)) + a(CHEBI:"reactive oxygen species") increases p(HGNC:NLRP3) - pmid:25652642 + pubmed:30962309 - bp(GO:"synaptic transmission, glutamatergic") increases act(complex(GO:"NF-kappaB complex")) + a(CHEBI:"reactive oxygen species") increases p(HGNC:PYCARD) - pmid:24511233 + pubmed:30962309 - bp(GO:"synaptic transmission, glutamatergic") association path(MESH:Schizophrenia) + a(CHEBI:"reactive oxygen species") increases p(HGNC:CASP1) - pmid:26813123 + pubmed:30962309 - bp(GO:"synaptic transmission, glutamatergic") association bp(GO:cognition) + a(CHEBI:"reactive oxygen species") increases p(HGNC:IL1B) - pmid:26813123 + pubmed:27794524 - bp(GO:"synaptic transmission, glutamatergic") association bp(HBP:Neurodegeneration) + a(CHEBI:"reactive oxygen species") directlyIncreases path(MESH:"Mitochondrial Diseases") - pmid:30106381 + pubmed:27794524 - bp(GO:"synaptic transmission, glutamatergic") positiveCorrelation p(HGNC:ADNP) + a(CHEBI:"reactive oxygen species") isA a(MESH:Neurotoxins) - pmid:30106381 + pubmed:27794524 - bp(GO:"synaptic transmission, glutamatergic") positiveCorrelation a(PUBCHEM:9832404) + tloc(a(CHEBI:"reactive oxygen species"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) directlyIncreases path(MESH:"Oxidative Stress") - pmid:25652642 + pubmed:17017864 - bp(GO:"calmodulin dependent kinase signaling pathway") increases act(complex(GO:"NF-kappaB complex")) + a(CHEBI:"reactive oxygen species") increases path(CONSO:"mitochondrial dysfunction") - pmid:25652642 + pubmed:30061532 - bp(GO:"phosphatidylinositol 3-kinase signaling") increases act(complex(GO:"NF-kappaB complex")) + a(CHEBI:"reactive oxygen species") association path(MESH:Schizophrenia) - pmid:19126755 + pubmed:30515821 - bp(GO:"phosphatidylinositol 3-kinase signaling") regulates r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + a(CHEBI:"reactive oxygen species") increases path(EFO:"neurotic disorder") - pmid:22040696 + pubmed:30515821 - bp(GO:"phosphatidylinositol 3-kinase signaling") decreases bp(GO:"neuron death") + a(CHEBI:"reactive oxygen species") increases path(DOID:"neurodegenerative disease") - pmid:22040696 + pubmed:30515821 - bp(GO:"phosphatidylinositol 3-kinase signaling") increases p(FPLX:CHRN) + a(CHEBI:"reactive oxygen species") positiveCorrelation bp(GO:"regulation of NMDA receptor activity") - pmid:25652642 + pubmed:30515821 - a(MESH:"I-kappa B Proteins") decreases act(complex(GO:"NF-kappaB complex")) + a(CHEBI:"reactive oxygen species") increases path(MESH:"Wounds and Injuries") - pmid:25652642 + pubmed:30515821 - p(HBP:"sAPP-beta") positiveCorrelation act(complex(GO:"NF-kappaB complex")) + a(CHEBI:"reactive oxygen species") negativeCorrelation path(MESH:"Mitochondrial Dynamics") - pmid:25652642 + pubmed:30515821 - act(p(HGNC:APOE)) association complex(GO:"NF-kappaB complex") + a(CHEBI:"reactive oxygen species") increases path(OMIT:0002643) - pmid:19293145 + pubmed:30688256 - p(HGNC:APOE) association bp(GO:"lipid metabolic process") + a(CHEBI:"reactive oxygen species") increases bp(GO:mitophagy) - pmid:19293145 + pubmed:30688256 - p(HGNC:APOE) association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + a(CHEBI:"reactive oxygen species") decreases bp(GO:mitophagy) - pmid:21718217 + pubmed:30688256 - p(HGNC:APOE) increases a(CHEBI:"high-density lipoprotein") + a(CHEBI:"reactive oxygen species") association bp(GO:mitophagy) - pmid:21718217 + pubmed:30688256 - p(HGNC:APOE) increases deg(a(CHEBI:"amyloid-beta")) + a(CHEBI:"reactive oxygen species") association path(MESH:"Amyotrophic Lateral Sclerosis") - pmid:21718217 + pubmed:24563850 - act(p(HGNC:APOE)) increases deg(a(CHEBI:"amyloid-beta")) + a(CHEBI:"reactive oxygen species") increases bp(GO:"negative regulation of inflammatory response") - pmid:26195256 + pubmed:24563850 - act(p(HGNC:APOE)) regulates a(CHEBI:"amyloid-beta") + a(CHEBI:"reactive oxygen species") regulates bp(GO:"response to hypoxia") - pmid:26195256 + pubmed:24563850 - tloc(p(HGNC:APOE), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Cardiovascular System")) negativeCorrelation tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Cardiovascular System")) + a(CHEBI:"reactive oxygen species") regulates bp(GO:"leukocyte activation") - pmid:26195256 + pubmed:24563850 - p(HGNC:APOE) regulates deg(a(CHEBI:"amyloid-beta")) + a(CHEBI:"reactive oxygen species") regulates bp(GO:"cell differentiation") - pmid:30106381 + pubmed:24563850 - p(HGNC:APOE) association a(PUBCHEM:9832404) + a(CHEBI:"reactive oxygen species") regulates bp(GO:"integrin activation") - pmid:30106381 + pubmed:28528849 - p(HGNC:APOE) increases path(MESH:"Alzheimer Disease") + a(CHEBI:"reactive oxygen species") increases act(complex(GO:"NADPH oxidase complex")) - - - + + + pubmed:16566606 + + a(CHEBI:"reactive oxygen species") decreases act(a(MESH:Neurons)) + - pmid:25652642 + pubmed:16566606 - composite(a(MESH:"amyloid beta-protein (25-35)"), complex(GO:"NF-kappaB complex")) increases sec(p(HGNC:TNF)) + a(CHEBI:"reactive oxygen species") increases bp(GO:"neuron death") - pmid:25652642 + pubmed:23702978 - composite(a(MESH:"amyloid beta-protein (25-35)"), complex(GO:"NF-kappaB complex")) increases sec(p(HGNC:NGF)) + a(CHEBI:"reactive oxygen species") increases act(p(HGNC:TRPM2)) - pmid:25652642 + pubmed:23702978 - composite(a(MESH:"amyloid beta-protein (25-35)"), complex(GO:"NF-kappaB complex")) increases sec(p(HGNC:BDNF)) + a(CHEBI:"reactive oxygen species") increases bp(GO:"apoptosome assembly") - pmid:25652642 + pubmed:30988501 - a(MESH:"amyloid beta-protein (25-35)") increases act(complex(GO:"NF-kappaB complex")) + a(CHEBI:"reactive oxygen species") increases path(CONSO:neurotoxicity) - pmid:19126755 + pubmed:21861815 - act(p(HGNC:NGF)) increases bp(GO:"MAPK cascade") + path(EFO:hypoxia) negativeCorrelation bp(GO:"energy homeostasis") - pmid:19126755 + pubmed:21861815 - act(p(HGNC:NGF)) increases complex(p(HGNC:JUN), p(HGNC:SP1)) + path(EFO:hypoxia) increases bp(GO:"neuron death") - pmid:19126755 + pubmed:21861815 - p(HGNC:NGF) regulates r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + path(EFO:hypoxia) increases path(DOID:"Alzheimer's disease") - pmid:18986241 + pubmed:21861815 - p(HGNC:NGF) isA a(MESH:D009414) + path(EFO:hypoxia) increases p(HGNC:BACE1) - pmid:18986241 + pubmed:21861815 - act(p(HGNC:NGF)) increases bp(GO:"GO:0000165") + path(EFO:hypoxia) increases complex(GO:"gamma-secretase complex") - pmid:18986241 + pubmed:21861815 - p(HGNC:NGF) causesNoChange path(MESH:D003929) + path(EFO:hypoxia) increases a(CHEBI:amyloid-beta) - pmid:18986241 + pubmed:21861815 - p(HGNC:NGF) causesNoChange path(MESH:D016263) + path(EFO:hypoxia) increases a(CONSO:"amyloid-beta aggregates") - pmid:18986241 + pubmed:21861815 - p(HGNC:NGF) causesNoChange path(MESH:D000544) + path(EFO:hypoxia) increases r(HGNC:TH) - pmid:18986241 + pubmed:31346362 - p(HGNC:NGF) association bp(GO:"GO:0060384") + path(NCIT:C82901) increases deg(a(MESH:Tissues)) - pmid:18986241 + pubmed:31346362 - p(HGNC:NGF) association bp(GO:"GO:0007269") + path(NCIT:C82901) negativeCorrelation a(MESH:"Anti-Inflammatory Agents") - pmid:18986241 + pubmed:31346362 - p(HGNC:NGF) association bp(GO:"GO:0048485") + path(NCIT:C82901) positiveCorrelation complex(GO:"inflammasome complex") - pmid:18986241 + pubmed:31346362 - p(HGNC:NGF) association path(MESH:D002100) + act(p(HGNC:PROC, var("?"))) decreases p(HGNC:BACE1, loc(GO:"neuron part")) - pmid:18986241 + pubmed:31346362 - p(HGNC:NGF) association path(MESH:D006930) + act(p(HGNC:PROC, var("?"))) decreases p(HGNC:APP) - pmid:18986241 + pubmed:31346362 - p(HGNC:NGF) decreases path(MESH:D060825) + act(p(HGNC:PROC, var("?"))) decreases path(DOID:"Alzheimer's disease") + + - pmid:25652642 + pubmed:28760828 - p(HGNC:GRM5) increases complex(a(GO:"NF-kappaB complex"), p(HGNC:REL)) + path(DOID:"Alzheimer's disease") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262), pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) - pmid:25652642 + pubmed:28760828 - p(HGNC:GRM5) increases act(p(HGNC:SOD2)) + path(DOID:"Alzheimer's disease") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 324)) - pmid:25652642 + pubmed:21427723 - p(HGNC:GRM5) increases act(p(HGNC:BCL2L1)) + path(DOID:"Alzheimer's disease") association path(CONSO:"4R tauopathy") - pmid:24653673 + pubmed:21427723 - p(HGNC:GRM5) association path(MESH:"Alzheimer Disease") + path(DOID:"Alzheimer's disease") association complex(p(CONSO:"3R tau"), p(CONSO:"4R tau")) - + + + pubmed:25031639 + + path(DOID:"Alzheimer's disease") negativeCorrelation bp(GO:"axonal transport") + - pmid:25652642 + pubmed:25031639 - complex(a(GO:"NF-kappaB complex"), p(HGNC:REL)) decreases act(a(CHEBI:"amyloid-beta")) + path(DOID:"Alzheimer's disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) - pmid:14556719 + pubmed:29661268 - bp(GO:"cell death") positiveCorrelation p(HGNC:GPR37) + path(DOID:"Alzheimer's disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) - pmid:23746257 + pubmed:29661268 - bp(GO:"cell death") negativeCorrelation bp(HBP:Proteostasis) + path(DOID:"Alzheimer's disease") increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) - pmid:18930136 + pubmed:25031639 - bp(GO:"cell death") negativeCorrelation a(GO:aggresome) + path(DOID:"Alzheimer's disease") increases p(CONSO:"KXGS motif", pmod(go:0006468 ! "protein phosphorylation")) - pmid:24561250 + pubmed:25031639 - bp(GO:"cell death") increases sec(a(CHEBI:ATP)) + path(DOID:"Alzheimer's disease") decreases p(CONSO:"KXGS motif", pmod(go:0006473 ! "protein acetylation")) - + + + pubmed:25031639 + + path(DOID:"Alzheimer's disease") decreases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) + - pmid:25652642 + pubmed:25031639 - complex(a(GO:"NF-kappaB complex"), p(HGNC:RELA)) positiveCorrelation path(MESH:"Alzheimer Disease") + path(DOID:"Alzheimer's disease") increases act(p(HGNC:HDAC6)) - pmid:19293145 + pubmed:25031639 - a(MESH:"Cholinergic Neurons") increases act(p(HGNC:CHAT)) + path(DOID:"Alzheimer's disease") negativeCorrelation a(MESH:Microtubules) - pmid:26813123 + pubmed:29661268 - act(a(MESH:"Cholinergic Neurons")) increases path(MESH:Attention) + path(DOID:"Alzheimer's disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 274)) - pmid:26813123 + pubmed:29661268 - a(MESH:"Cholinergic Neurons") increases path(MESH:Attention) + path(DOID:"Alzheimer's disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 274)) - pmid:26813123 + pubmed:29661268 - a(MESH:"Cholinergic Neurons") positiveCorrelation bp(GO:memory) + path(DOID:"Alzheimer's disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 281)) - pmid:26813123 + pubmed:29661268 - a(MESH:"Cholinergic Neurons") increases bp(GO:memory) + path(DOID:"Alzheimer's disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 174)) - pmid:26813123 + pubmed:29661268 - a(MESH:"Cholinergic Neurons") increases bp(GO:"circadian sleep/wake cycle, REM sleep") + path(DOID:"Alzheimer's disease") decreases act(p(HGNC:PPP2CA)) - pmid:26813123 + pubmed:29661268 - a(MESH:"Cholinergic Neurons") increases a(CHEBI:acetylcholine) + path(DOID:"Alzheimer's disease") increases p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) - pmid:26813123 + pubmed:29661268 - a(MESH:"Cholinergic Neurons") increases a(CHEBI:choline) + path(DOID:"Alzheimer's disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) - pmid:26813123 + pubmed:29661268 - a(MESH:"Cholinergic Neurons") increases tloc(p(HGNC:ACHE), fromLoc(MESH:"Synaptic Vesicles"), toLoc(GO:"synaptic cleft")) + path(DOID:"Alzheimer's disease") increases p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) - pmid:26813123 + pubmed:29661268 - a(MESH:"Cholinergic Neurons") increases bp(GO:"synaptic transmission, dopaminergic") + path(DOID:"Alzheimer's disease") negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:26813123 + pubmed:30515821 - a(MESH:"Cholinergic Neurons") decreases path(MESH:Apathy) + path(DOID:"Alzheimer's disease") negativeCorrelation path(MESH:"Mitochondrial Dynamics") - pmid:26813123 + pubmed:27190210 - a(MESH:"Cholinergic Neurons") decreases path(MESH:Depression) + path(DOID:"Alzheimer's disease") decreases p(HGNC:CHRNA7) - pmid:26813123 + pubmed:22530628 - a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Alzheimer Disease") + path(DOID:"Alzheimer's disease") decreases p(HGNC:CHRNA7) - pmid:26813123 + pubmed:22530628 - a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Parkinson Disease") + path(DOID:"Alzheimer's disease") association p(HGNC:CHRNA7) - pmid:26813123 + pubmed:22530628 - a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Down Syndrome") + path(DOID:"Alzheimer's disease") decreases p(HGNC:CHRNA7) - pmid:26813123 + pubmed:27190210 - a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") + path(DOID:"Alzheimer's disease") association g(HGNC:CHRNA7) - pmid:26813123 + pubmed:27190210 - a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Supranuclear Palsy, Progressive") + path(DOID:"Alzheimer's disease") association complex(CONSO:"alpha-7 beta-2 nAChR") - pmid:26813123 + pubmed:22530628 - a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Olivopontocerebellar Atrophies") + path(DOID:"Alzheimer's disease") increases path(MESH:"Memory Disorders") - pmid:26813123 + pubmed:22530628 - a(MESH:"Cholinergic Neurons") association act(p(HGNC:CHRM1)) + path(DOID:"Alzheimer's disease") decreases a(CHEBI:acetylcholine) - pmid:28901280 + pubmed:22530628 - a(MESH:"Cholinergic Neurons") increases a(MESH:Acetylcholine) + path(DOID:"Alzheimer's disease") decreases p(HGNC:CHRNA3) - - - pmid:19293145 + pubmed:22530628 - tloc(p(HGNC:BAX), fromLoc(GO:cytosol), toLoc(GO:mitochondrion)) increases bp(GO:"apoptotic process") + path(DOID:"Alzheimer's disease") decreases p(HGNC:CHRNA4) - pmid:21722302 + pubmed:22530628 - p(HGNC:BAX) increases act(p(HGNC:ERN1), ma(kin)) + path(DOID:"Alzheimer's disease") decreases act(p(HGNC:CHAT)) - pmid:21722302 + pubmed:22530628 - p(HGNC:BAX) increases bp(GO:"mitochondrial outer membrane permeabilization") + path(DOID:"Alzheimer's disease") negativeCorrelation path(MESH:"Tobacco Use") - pmid:21722302 + pubmed:22530628 - p(HGNC:BAX) increases complex(GO:"mitochondrial permeability transition pore complex") + path(DOID:"Alzheimer's disease") decreases complex(CONSO:"alpha-4 beta-2 nAChR") - pmid:25652642 + pubmed:31248781 - bp(GO:"positive regulation of advanced glycation end-product receptor activity") increases act(a(MESH:Microglia)) + path(DOID:"Alzheimer's disease") decreases path(MESH:Attention) - pmid:25652642 + pubmed:31248781 - bp(GO:"peroxisome proliferator activated receptor signaling pathway") increases act(a(MESH:Microglia)) + path(DOID:"Alzheimer's disease") decreases path(MESH:Orientation) - pmid:25652642 + pubmed:31248781 - p(MESH:"I-kappa B Proteins", pmod(Ph)) increases act(a(MESH:Microglia)) + path(DOID:"Alzheimer's disease") decreases bp(GO:"learning or memory") - - - pmid:25652642 + pubmed:31248781 - a(MESH:"HLA-DR Antigens") association path(MESH:"Plaque, Amyloid") + path(DOID:"Alzheimer's disease") decreases path(MESH:"Executive Function") - pmid:25652642 + pubmed:31248781 - a(MESH:"HLA-DR Antigens") positiveCorrelation path(MESH:"Alzheimer Disease") + path(DOID:"Alzheimer's disease") decreases path(MESH:Judgment) - pmid:25652642 + pubmed:31248781 - m(HGNC:"MIR9-1") positiveCorrelation path(MESH:"Alzheimer Disease") + path(DOID:"Alzheimer's disease") increases path(MESH:"Language Disorders") - pmid:25652642 + pubmed:31248781 - m(HGNC:MIR34A) positiveCorrelation path(MESH:"Alzheimer Disease") + path(DOID:"Alzheimer's disease") increases path(DOID:"mental depression") - pmid:25652642 + pubmed:31248781 - m(HGNC:MIR125B1) positiveCorrelation path(MESH:"Alzheimer Disease") + path(DOID:"Alzheimer's disease") increases path(MESH:"Anxiety Disorders") - pmid:25652642 + pubmed:31248781 - m(HGNC:MIR125B1) positiveCorrelation p(HGNC:GFAP) + path(DOID:"Alzheimer's disease") increases path(HP:Agitation) - pmid:25652642 + pubmed:31248781 - m(HGNC:MIR125B1) positiveCorrelation p(HGNC:VIM) + path(DOID:"Alzheimer's disease") increases path(DOID:"sleep disorder") - pmid:25652642 + pubmed:31248781 - m(HGNC:MIR125B1) positiveCorrelation p(HGNC:CDKN2A) + path(DOID:"Alzheimer's disease") decreases p(HGNC:CREBBP) - pmid:25652642 + pubmed:29428175 - m(HGNC:MIR146A) positiveCorrelation path(MESH:"Alzheimer Disease") + path(DOID:"Alzheimer's disease") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:25652642 + pubmed:26979166 - m(HGNC:MIR155) positiveCorrelation path(MESH:"Alzheimer Disease") + path(DOID:"Alzheimer's disease") positiveCorrelation path(MESH:Smoking) - pmid:25652642 + pubmed:26979166 - m(HGNC:MIR339) positiveCorrelation path(MESH:"Alzheimer Disease") + path(DOID:"Alzheimer's disease") positiveCorrelation path(MESH:Smoking) - pmid:25652642 + pubmed:23516100 - p(HGNC:VIM) positiveCorrelation m(HGNC:MIR125B1) + path(DOID:"Alzheimer's disease") increases p(HGNC:MAPT, frag("?"), loc(CONSO:"paired helical filaments")) - - - pmid:25652642 + pubmed:23516100 - p(HGNC:CDKN2A) positiveCorrelation m(HGNC:MIR125B1) + path(DOID:"Alzheimer's disease") positiveCorrelation p(HGNC:MAPT, frag("?")) - pmid:30126037 + pubmed:23516100 - p(HGNC:CDKN2A) association a(GO:"neurofibrillary tangle") + path(DOID:"Alzheimer's disease") increases p(HGNC:MAPT, frag("1_391"), loc(CONSO:"paired helical filaments")) - pmid:30126037 + pubmed:23516100 - p(HGNC:CDKN2A) positiveCorrelation a(GO:"neurofibrillary tangle") + path(DOID:"Alzheimer's disease") increases p(HGNC:MAPT, frag("1_421")) - pmid:30126037 + pubmed:23516100 - p(HGNC:CDKN2A) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") + path(DOID:"Alzheimer's disease") increases p(HGNC:APP, frag("1_?")) - pmid:30126037 + pubmed:23516100 - p(HGNC:CDKN2A) association bp(HP:Neurodegeneration) + path(DOID:"Alzheimer's disease") increases a(CHEBI:amyloid-beta) - pmid:30126037 + pubmed:23516100 - p(HGNC:CDKN2A) association path(MESH:"Cognitive Dysfunction") + path(DOID:"Alzheimer's disease") increases complex(complex(GO:"mitochondrial protein complex"), p(HGNC:APP, frag("1_?"))) - pmid:30232325 + pubmed:23516100 - act(p(HGNC:WNT3A)) increases bp(GO:"canonical Wnt signaling pathway") + path(DOID:"Alzheimer's disease") negativeCorrelation bp(GO:"calcium ion homeostasis") - pmid:30232325 + pubmed:23516100 - act(p(HGNC:WNT3A)) increases bp(GO:"canonical Wnt signaling pathway") + path(DOID:"Alzheimer's disease") decreases act(p(HGNCGENEFAMILY:Calpains)) - pmid:30232325 + pubmed:23516100 - act(p(HGNC:WNT3A)) decreases a(CHEBI:"amyloid-beta") + path(DOID:"Alzheimer's disease") positiveCorrelation act(p(HGNCGENEFAMILY:Calpains)) - pmid:30232325 + pubmed:23516100 - act(p(HGNC:WNT3A)) increases a(CHEBI:"amyloid-beta") + path(DOID:"Alzheimer's disease") negativeCorrelation bp(GO:"cytoskeleton organization") - pmid:30232325 + pubmed:23516100 - bp(GO:"canonical Wnt signaling pathway") association p(HGNC:LRP6) + path(DOID:"Alzheimer's disease") increases p(HGNC:MAPT, frag("?_*")) - pmid:30232325 + pubmed:23516100 - bp(GO:"canonical Wnt signaling pathway") decreases a(CHEBI:"amyloid-beta") + path(DOID:"Alzheimer's disease") increases p(HGNC:CASP3) - pmid:30232325 + pubmed:23516100 - bp(GO:"canonical Wnt signaling pathway") negativeCorrelation bp(GO:"amyloid-beta formation") + path(DOID:"Alzheimer's disease") increases p(HGNC:TARDBP, frag("?")) - pmid:30232325 + pubmed:23516100 - act(p(HGNC:WNT5A)) increases bp(GO:"Wnt signaling pathway, planar cell polarity pathway") + path(DOID:"Alzheimer's disease") negativeCorrelation a(GO:lysosome) - pmid:30232325 + pubmed:23516100 - bp(GO:"Wnt signaling pathway, planar cell polarity pathway") association p(HGNC:VANGL2) + path(DOID:"Alzheimer's disease") increases p(HGNC:CTSD) - pmid:30232325 + pubmed:23516100 - bp(GO:"Wnt signaling pathway, planar cell polarity pathway") increases a(CHEBI:"amyloid-beta") + path(DOID:"Alzheimer's disease") increases p(HGNC:APP, frag("1_35")) - pmid:30232325 + pubmed:21861815 - bp(GO:"Wnt signaling pathway, planar cell polarity pathway") positiveCorrelation bp(GO:"amyloid-beta formation") + path(DOID:"Alzheimer's disease") decreases bp(NCIT:C94869) - + + + pubmed:21861815 + + path(DOID:"Alzheimer's disease") negativeCorrelation bp(GO:"glucose metabolic process") + - pmid:30232325 + pubmed:21861815 - p(HGNC:VANGL2) association bp(GO:"Wnt signaling pathway, planar cell polarity pathway") + path(DOID:"Alzheimer's disease") negativeCorrelation bp(GO:"glucose import") - + + + pubmed:21861815 + + path(DOID:"Alzheimer's disease") increases bp(NCIT:C17741) + - pmid:30232325 + pubmed:21861815 - p(HGNC:LRP6) association bp(GO:"canonical Wnt signaling pathway") + path(DOID:"Alzheimer's disease") decreases r(HGNC:SLC2A1) - + + + pubmed:21861815 + + path(DOID:"Alzheimer's disease") decreases r(HGNC:SLC2A3) + - pmid:30232325 + pubmed:26968346 - composite(p(HGNC:APP), p(HGNC:LRP6)) increases bp(GO:"canonical Wnt signaling pathway") + path(DOID:"Alzheimer's disease") increases m(MIRBASE:hsa-mir-128-1) - pmid:30232325 + pubmed:27299292 - composite(p(HGNC:APP), p(HGNC:LRP6)) decreases bp(GO:"Wnt signaling pathway, planar cell polarity pathway") + path(DOID:"Alzheimer's disease") increases m(MIRBASE:hsa-mir-128-1) - pmid:30232325 + pubmed:26968346 - composite(p(HGNC:APP), p(HGNC:LRP6)) decreases a(CHEBI:"amyloid-beta") + path(DOID:"Alzheimer's disease") increases m(MIRBASE:hsa-mir-128-2) - + + + pubmed:27299292 + + path(DOID:"Alzheimer's disease") decreases p(HGNC:TFEB) + - pmid:30232325 + pubmed:27299292 - composite(p(HGNC:APP), p(HGNC:VANGL2)) decreases bp(GO:"canonical Wnt signaling pathway") + path(DOID:"Alzheimer's disease") negativeCorrelation p(HGNC:PSEN1) - pmid:30232325 + pubmed:23384725 - composite(p(HGNC:APP), p(HGNC:VANGL2)) increases bp(GO:"Wnt signaling pathway, planar cell polarity pathway") + path(DOID:"Alzheimer's disease") association composite(a(MESH:"Inclusion Bodies"), p(HGNC:TARDBP)) - pmid:30232325 + pubmed:28669544 - composite(p(HGNC:APP), p(HGNC:VANGL2)) increases a(CHEBI:"amyloid-beta") + path(DOID:"Alzheimer's disease") directlyIncreases path(MESH:"Neuronal Plasticity") - pmid:30232325 + pubmed:30988501 - p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) decreases bp(GO:"canonical Wnt signaling pathway") + path(DOID:"Alzheimer's disease") positiveCorrelation a(MESH:"Herpesvirus 1, Human") - pmid:30232325 + pubmed:31346362 - p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) increases bp(GO:"non-canonical Wnt signaling pathway") + p(OMIT:0018975) decreases p(MESH:Proteins, pmod(MESH:Polymers)) - pmid:30232325 + pubmed:31346362 - p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) increases a(CHEBI:"amyloid-beta") + p(OMIT:0018975) decreases p(CONSO:"amyloid-beta aggregates") + + + + + + + + + + + + + + + + + + + + - pmid:11230871 + pubmed:30606258 - p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) association act(p(HGNC:APP)) + p(MESH:Proteins, loc(GO:"synaptic membrane")) negativeCorrelation p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) + + + + + + + + + + + + + + - pmid:11230871 + pubmed:31346362 - p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) increases path(MESH:"Plaque, Amyloid") + a(CHEBI:"acetylsalicylic acid") decreases p(MESH:Proteins, pmod(MESH:Polymers)) - pmid:11230871 + pubmed:31346362 - p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) negativeCorrelation p(FPLX:CHRN) + a(CHEBI:"acetylsalicylic acid") decreases p(CONSO:"amyloid-beta aggregates") - pmid:30232325 + pubmed:31346362 - bp(GO:"amyloid-beta formation") negativeCorrelation bp(GO:"canonical Wnt signaling pathway") + a(CHEBI:"acetylsalicylic acid") increases p(MESH:Proteins, pmod(go:0006473 ! "protein acetylation")) - pmid:30232325 + pubmed:31346362 - bp(GO:"amyloid-beta formation") positiveCorrelation bp(GO:"Wnt signaling pathway, planar cell polarity pathway") + a(CHEBI:"acetylsalicylic acid") decreases p(MESH:Proteins, pmod(go:0006468 ! "protein phosphorylation")) - pmid:30232325 + pubmed:31346362 - act(p(HGNC:DKK1)) decreases act(p(HGNC:WNT3A)) + a(CHEBI:"acetylsalicylic acid") decreases p(HGNCGENEFAMILY:"NF-kappa B complex subunits") - pmid:30232325 + pubmed:31346362 - act(p(HGNC:DKK1)) decreases bp(GO:"canonical Wnt signaling pathway") + a(CHEBI:"acetylsalicylic acid") decreases p(MESH:"Prostaglandin-Endoperoxide Synthases") - pmid:30232325 + pubmed:21329555 - act(p(HGNC:DKK1)) increases act(p(HGNC:WNT5A)) + a(CHEBI:"acetylsalicylic acid") decreases r(HGNC:BACE1) - pmid:30232325 + pubmed:21329555 - act(p(HGNC:DKK1)) increases bp(GO:"Wnt signaling pathway, planar cell polarity pathway") + a(CHEBI:"acetylsalicylic acid") decreases r(HGNC:BACE1) - pmid:30232325 + pubmed:21329555 - p(HGNC:DKK1) increases bp(HBP:HBP00061) + a(CHEBI:"acetylsalicylic acid") isA a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") - pmid:30232325 + pubmed:31346362 - p(HGNC:DKK1) decreases a(MESH:"Dendritic Spines") + p(MESH:Proteins, pmod(go:0006473 ! "protein acetylation")) decreases p(MESH:Proteins, pmod(go:0006468 ! "protein phosphorylation")) - pmid:30232325 + pubmed:31346362 - p(HGNC:DKK1) decreases a(MESH:"Dendritic Spines") + a(CHEBI:digoxin) decreases p(HGNC:HIF1A) - pmid:30232325 + pubmed:31346362 - p(HGNC:DKK1) increases a(CHEBI:"amyloid-beta") + a(PUBCHEM:443101) decreases p(HGNC:HIF1A) - pmid:30232325 + pubmed:31346362 - p(HGNC:DKK1) increases bp(GO:"amyloid-beta formation") + a(CHEBI:doxorubicin) decreases p(HGNC:HIF1A) - pmid:18494933 + pubmed:26751493 - p(HGNC:DKK1) increases act(p(HGNC:GSK3B)) + a(CHEBI:doxorubicin) decreases p(CONSO:"Tau aggregates") - pmid:18494933 + pubmed:31346362 - p(HGNC:DKK1) increases act(p(HGNC:GSK3B), ma(kin)) + a(CHEBI:chetomin) decreases p(HGNC:HIF1A) - pmid:18494933 + pubmed:31346362 - p(HGNC:DKK1) decreases bp(GO:"Wnt signaling pathway") + a(MESH:"Anti-Inflammatory Agents") negativeCorrelation path(NCIT:C82901) - pmid:18494933 + pubmed:31346362 - p(HGNC:DKK1) positiveCorrelation deg(p(HGNC:CTNNB1)) + a(MESH:"Anti-Inflammatory Agents") negativeCorrelation a(CHEBI:"reactive oxygen species") - + + + pubmed:31346362 + + a(CHEBI:curcumin) decreases p(MESH:"Glycation End Products, Advanced") + - pmid:30232325 + pubmed:31346362 - composite(p(HGNC:APP), p(HGNC:DKK1)) decreases a(MESH:"Dendritic Spines") + deg(a(CHEBI:curcumin)) increases a(CHEBI:vanillin) - pmid:24760868 + pubmed:29179999 - a(MESH:"Dendritic Spines") increases complex(a(MESH:"Dendritic Spines"), p(HGNC:MAPT)) + a(CHEBI:curcumin) decreases bp(GO:"inflammatory response") - pmid:27796283 + pubmed:29179999 - a(MESH:"Dendritic Spines") positiveCorrelation bp(GO:"dendritic spine development") + a(CHEBI:curcumin) decreases p(HGNC:PTGS2) - pmid:27796283 + pubmed:29179999 - a(MESH:"Dendritic Spines") negativeCorrelation act(p(HGNC:RHOA)) + a(CHEBI:curcumin) decreases p(HGNC:LOX) - pmid:27796283 + pubmed:29179999 - a(MESH:"Dendritic Spines") positiveCorrelation p(HGNC:CAMKV) + a(CHEBI:curcumin) decreases p(HGNC:NOS2) - pmid:30232325 + pubmed:29179999 - a(CHEBI:"fasudil hydrochloride") decreases bp(GO:"Wnt signaling pathway, planar cell polarity pathway") + a(CHEBI:curcumin) decreases p(HGNC:TNF) - pmid:30232325 + pubmed:29179999 - a(CHEBI:"fasudil hydrochloride") decreases a(CHEBI:"amyloid-beta polypeptide 40") + a(CHEBI:curcumin) decreases p(HGNC:IL1A) - pmid:30232325 + pubmed:29179999 - a(CHEBI:"fasudil hydrochloride") decreases a(CHEBI:"amyloid-beta polypeptide 40") + a(CHEBI:curcumin) decreases p(HGNC:IL2) - + + + pubmed:29179999 + + a(CHEBI:curcumin) decreases p(HGNC:IL6) + - pmid:30232325 + pubmed:29179999 - composite(a(CHEBI:"fasudil hydrochloride"), p(HGNC:DKK1)) causesNoChange a(MESH:"Dendritic Spines") + a(CHEBI:curcumin) decreases p(HGNC:CXCL8) - pmid:30232325 + pubmed:29179999 - composite(a(CHEBI:"fasudil hydrochloride"), p(HGNC:DKK1)) causesNoChange a(CHEBI:"amyloid-beta") + a(CHEBI:curcumin) decreases p(HGNC:IL12B) - pmid:19293145 + pubmed:29179999 - a(HBP:"sAPP-beta") decreases act(a(CHEBI:"amyloid-beta")) + a(CHEBI:curcumin) decreases a(MESH:Neurotoxins) - pmid:10656250 + pubmed:29179999 - p(HGNC:BACE1, var("p.?")) causesNoChange sec(a(HBP:"sAPP-beta")) + a(CHEBI:curcumin) decreases act(p(FPLX:NFkappaB)) - pmid:24590577 + pubmed:29179999 - a(HBP:"sAPP-alpha") increases bp(MESH:Neuroprotection) + a(CHEBI:curcumin) decreases p(HGNC:NFKBIA, pmod(go:0006468 ! "protein phosphorylation")) - pmid:10656250 + pubmed:29179999 - p(HGNC:CTSD) causesNoChange sec(a(HBP:"sAPP-beta")) + a(CHEBI:curcumin) decreases deg(p(HGNC:NFKBIA)) - pmid:18930136 + pubmed:29179999 - p(HGNC:CTSD) isA a(GO:autolysosome) + a(CHEBI:curcumin) decreases tloc(p(HGNC:RELA), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) - pmid:18930136 + pubmed:26551702 - p(HGNC:CTSD) decreases path(HBP:Neurodegeneration) + a(CHEBI:curcumin) decreases path(MESH:Inflammation) - pmid:18930136 + pubmed:26551702 - p(HGNC:CTSD) negativeCorrelation a(GO:lysosome) + a(CHEBI:curcumin) increases act(p(HGNC:NFE2L2)) - pmid:18930136 + pubmed:26551702 - p(HGNC:CTSD) negativeCorrelation a(GO:autophagosome) + a(CHEBI:curcumin) increases bp(GO:"response to oxidative stress") - pmid:24027553 + pubmed:22530628 - act(p(HGNC:CTSD)) increases p(HGNC:MAPT, frag("?", "29kD")) + a(CHEBI:curcumin) decreases a(CONSO:"amyloid-beta oligomers") - pmid:24027553 + pubmed:30116051 - act(p(HGNC:CTSD)) increases deg(p(HGNC:MAPT)) + a(CHEBI:curcumin) decreases a(CONSO:"amyloid-beta oligomers") - pmid:24027553 + pubmed:22530628 - act(p(HGNC:CTSD)) increases deg(p(HGNC:MAPT)) + a(CHEBI:curcumin) causesNoChange a(CONSO:"amyloid-beta fibrils") - pmid:23528736 + pubmed:28803412 - p(HGNC:CTSD) increases deg(p(HGNC:MAPT)) + a(CHEBI:curcumin) decreases a(CONSO:CONSO00092) - pmid:29626319 + pubmed:28803412 - p(HGNC:CTSD) increases deg(p(HGNC:MAPT)) + a(CHEBI:curcumin) decreases a(CONSO:CONSO00016) - pmid:24027553 + pubmed:28803412 - act(p(HGNC:CTSD)) increases p(HGNC:MAPT, frag("?", "29kD"), pmod(Ph)) + a(CHEBI:curcumin) decreases a(CONSO:CONSO00018) - pmid:24027553 + pubmed:30116051 - act(p(HGNC:CTSD)) increases path(MESH:Neuroprotection) + a(CHEBI:curcumin) increases bp(GO:macroautophagy) - pmid:24027553 + pubmed:30116051 - act(p(HGNC:CTSD)) decreases path(HBP:neurotoxicity) + a(CHEBI:curcumin) decreases act(p(FPLX:mTORC1)) - pmid:10656250 + pubmed:30116051 - a(HBP:APP695) association p(HGNC:BACE1) + a(CHEBI:curcumin) increases deg(p(HGNC:SNCA, var("p.Ala53Thr"))) - pmid:10656250 + pubmed:30116051 - a(HBP:APP751) association p(HGNC:BACE1) + a(CHEBI:curcumin) decreases a(CONSO:"alpha-synuclein aggregates") - pmid:22791904 + pubmed:30116051 - a(PUBCHEM:11249342) increases path(MESH:Nausea) + a(CHEBI:curcumin) decreases a(CONSO:"Tau oligomers") - pmid:22791904 + pubmed:31346362 - a(PUBCHEM:11249342) causesNoChange path(MESH:Nausea) + a(CHEBI:vanillin) decreases p(MESH:"Glycation End Products, Advanced") - pmid:22791904 + pubmed:22530628 - a(PUBCHEM:11249342) increases path(MESH:Vomiting) + a(CHEBI:vanillin) decreases a(CONSO:"amyloid-beta oligomers") - pmid:22791904 + pubmed:22530628 - a(PUBCHEM:11249342) causesNoChange path(MESH:Vomiting) + a(CHEBI:vanillin) decreases a(CONSO:"amyloid-beta fibrils") - pmid:22791904 + pubmed:31346362 - a(PUBCHEM:11249342) decreases p(HBP:"sAPP-alpha") + path(EFO:"physical activity") decreases path(DOID:"Alzheimer's disease") - pmid:22791904 + pubmed:31346362 - a(PUBCHEM:11249342) decreases p(HBP:"sAPP-beta") + p(HGNC:BDNF) decreases bp(GO:"programmed cell death") - pmid:22791904 + pubmed:28745240 - a(PUBCHEM:11249342) decreases p(HGNC:MAPT) + p(HGNC:BDNF) increases bp(MESH:"Neuronal Outgrowth") - pmid:22791904 + pubmed:28745240 - a(PUBCHEM:11249342) decreases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:BDNF) increases act(complex(GO:"NF-kappaB complex")) - pmid:22791904 + pubmed:28745240 - a(PUBCHEM:11249342) decreases p(HGNC:C3) + p(HGNC:BDNF) increases act(p(HGNC:SRC)) - pmid:22791904 + pubmed:27794524 - a(PUBCHEM:11249342) decreases p(HGNC:CCL2) + p(HGNC:BDNF) association bp(GO:"axon development") - pmid:22791904 + pubmed:30967783 - a(PUBCHEM:11249342) decreases p(HGNC:CHI3L1) + p(HGNC:BDNF) increases act(p(HGNC:NTRK2)) - pmid:22791904 + pubmed:30967783 - a(PUBCHEM:11249342) causesNoChange p(HGNC:CFH) + p(HGNC:BDNF) increases a(GO:synapse) - pmid:19721446 + pubmed:30967783 - path(MESH:Nausea) association a(MESH:"5-(2-azetidinylmethoxy)-2-chloropyridine") + p(HGNC:BDNF) increases bp(GO:"learning or memory") - pmid:19721446 + pubmed:21677163 - path(MESH:Vomiting) association a(MESH:"5-(2-azetidinylmethoxy)-2-chloropyridine") + p(HGNC:BDNF) positiveCorrelation p(FPLX:CREB) - pmid:21718217 + pubmed:11880483 - p(HGNC:CCL2) increases bp(GO:"microglial cell activation") + p(HGNC:BDNF) association p(HGNCGENEFAMILY:"Mitogen-activated protein kinases", pmod(go:0006468 ! "protein phosphorylation")) - pmid:30444369 + pubmed:11880483 - a(CHEBI:tacrine) increases bp(GO:cognition) + p(HGNC:BDNF) association p(FPLX:p38, pmod(go:0006468 ! "protein phosphorylation")) - pmid:30444369 + pubmed:26876488 - a(CHEBI:tacrine) decreases act(p(FPLX:Cholinesterase)) + p(HGNC:BDNF) decreases a(NIFT:"Cortical Thickness") - pmid:19293145 + pubmed:22530628 - a(CHEBI:tacrine) increases p(HGNC:BCL2) + p(HGNC:BDNF) increases p(HGNC:ARC) - pmid:19293145 + pubmed:31248781 - act(a(CHEBI:tacrine)) negativeCorrelation g(HGNC:APOE) + p(HGNC:BDNF) regulates bp(MESH:"Neuronal Plasticity") - pmid:24511233 + pubmed:22040696 - a(CHEBI:tacrine) isA a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") + p(HGNC:BDNF) regulates bp(GO:"peripheral nervous system development") - pmid:11230871 + pubmed:22040696 - a(CHEBI:tacrine) decreases act(p(HGNC:ACHE)) + p(HGNC:BDNF) regulates bp(GO:"central nervous system development") - pmid:11230871 + pubmed:22040696 - a(CHEBI:tacrine) increases act(p(HGNC:ACHE)) + p(HGNC:BDNF) increases bp(GO:"regulation of synaptic plasticity") - pmid:11230871 + pubmed:22040696 - a(CHEBI:tacrine) increases act(p(FPLX:CHRN)) + p(HGNC:BDNF) increases bp(GO:"spontaneous synaptic transmission") - pmid:11230871 + pubmed:22040696 - a(CHEBI:tacrine) increases p(FPLX:CHRN) + p(HGNC:BDNF) increases bp(GO:"synaptic transmission, GABAergic") - pmid:11230871 + pubmed:22040696 - a(CHEBI:tacrine) increases p(FPLX:CHRN) + p(HGNC:BDNF) increases bp(GO:"maintenance of synapse structure") - pmid:30444369 + pubmed:22040696 - a(CHEBI:donepezil) increases bp(GO:cognition) + p(HGNC:BDNF) association p(HGNC:CHRNA7) - pmid:26813123 + pubmed:22040696 - a(CHEBI:donepezil) increases bp(GO:cognition) + p(HGNC:BDNF) increases p(HGNC:CHRNA7) - pmid:30444369 + pubmed:22040696 - a(CHEBI:donepezil) decreases act(p(FPLX:Cholinesterase)) + p(HGNC:BDNF) increases tloc(p(HGNC:CHRNA7), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) - pmid:19126755 + pubmed:22179319 - a(CHEBI:donepezil) decreases p(HGNC:ACHE) + p(HGNC:BDNF) increases path(MESH:Neuroprotection) - pmid:11230871 + pubmed:22179319 - a(CHEBI:donepezil) decreases act(p(HGNC:ACHE)) + p(HGNC:BDNF) increases bp(GO:"striatal medium spiny neuron differentiation") - pmid:19293145 + pubmed:22179319 - a(CHEBI:donepezil) isA a(CHEBI:"EC 3.1.1.8 (cholinesterase) inhibitor") + p(HGNC:BDNF) decreases path(MESH:"Nerve Degeneration") - pmid:19293145 + pubmed:22179319 - a(CHEBI:donepezil) decreases path(MESH:"Alzheimer Disease") + p(HGNC:BDNF) regulates path(MESH:"Carbohydrate Metabolism") - pmid:19293145 + pubmed:22179319 - a(CHEBI:donepezil) decreases path(HBP:neurotoxicity) + p(HGNC:BDNF) decreases a(MESH:"Blood Glucose") - pmid:19293145 + pubmed:22179319 - a(CHEBI:donepezil) decreases path(HBP:neurotoxicity) + p(HGNC:BDNF) association p(HGNC:PPP1R1B) - pmid:19293145 + pubmed:27013968 - a(CHEBI:donepezil) regulates act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + act(p(HGNC:BDNF), ma(GO:"brain-derived neurotrophic factor binding")) negativeCorrelation p(HGNC:HTT, pmod(HBP:"CAG repeats")) + + - pmid:19293145 + pubmed:27013968 - a(CHEBI:donepezil) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + p(HGNC:BDNF) increases act(p(HGNC:NTRK2, pmod(go:0006468 ! "protein phosphorylation"))) - pmid:19293145 + pubmed:27013968 - a(CHEBI:donepezil) increases p(HGNC:CHRNA4) + p(HGNC:BDNF) increases p(HGNC:NTRK2, pmod(go:0006468 ! "protein phosphorylation")) - pmid:19293145 + pubmed:27013968 - a(CHEBI:donepezil) increases p(HGNC:CHRNA7) + p(HGNC:BDNF) increases bp(MESH:"Cell Survival") - pmid:19293145 + pubmed:27013968 - a(CHEBI:donepezil) increases bp(MESH:Neuroprotection) + p(HGNC:BDNF) increases bp(MESH:"Cell Survival") - pmid:19293145 + pubmed:27013968 - a(CHEBI:donepezil) increases p(HGNC:BCL2) + p(HGNC:BDNF) increases p(PFAM:DARPP-32) - pmid:24511233 + pubmed:27013968 - a(CHEBI:donepezil) isA a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") + p(HGNC:BDNF) increases p(PFAM:DARPP-32) + + - pmid:18986241 + pubmed:27013968 - a(CHEBI:donepezil) increases act(a(MESH:D005625)) + p(HGNC:BDNF) decreases bp(MESH:Apoptosis) - pmid:11230871 + pubmed:30027901 - a(CHEBI:donepezil) increases act(p(FPLX:CHRN)) + p(HGNC:BDNF) increases bp(GO:"cell growth") + + - pmid:11230871 + pubmed:30027901 - a(CHEBI:donepezil) increases p(FPLX:CHRN) + p(HGNC:BDNF) biomarkerFor bp(MESH:Neuroprotection) - pmid:29626319 + pubmed:30740335 - a(CHEBI:donepezil) increases p(HGNC:ABCB1) + p(HGNC:BDNF) regulates path(MESH:"Neuronal Plasticity") - pmid:29626319 + pubmed:30740335 - a(CHEBI:donepezil) increases p(HGNC:LRP1) + p(HGNC:BDNF) regulates path(MESH:"Long-Term Potentiation") - pmid:29626319 + pubmed:30740335 - a(CHEBI:donepezil) decreases a(CHEBI:"amyloid-beta") + p(HGNC:BDNF) association act(p(HGNC:XBP1)) - pmid:30444369 + pubmed:30985105 - a(CHEBI:rivastigmine) increases bp(GO:cognition) + p(HGNC:BDNF) association p(HGNC:HTT) - pmid:30444369 + pubmed:28632203 - a(CHEBI:rivastigmine) decreases act(p(FPLX:Cholinesterase)) + p(HGNC:BDNF) biomarkerFor path(MESH:"Alzheimer Disease") + + - pmid:19126755 + pubmed:31346362 - a(CHEBI:rivastigmine) decreases p(HGNC:ACHE) + p(HGNC:IGF1) decreases bp(GO:"programmed cell death") - pmid:11230871 + pubmed:27794524 - a(CHEBI:rivastigmine) decreases act(p(HGNC:ACHE)) + p(HGNC:IGF1) association bp(GO:"axon development") - pmid:19293145 + pubmed:30967783 - a(CHEBI:rivastigmine) isA a(CHEBI:"EC 3.1.1.8 (cholinesterase) inhibitor") + p(HGNC:IGF1) increases bp(MESH:"Cell Survival") - pmid:19293145 + pubmed:30967783 - a(CHEBI:rivastigmine) decreases path(MESH:"Alzheimer Disease") + p(HGNC:IGF1) increases bp(GO:neurogenesis) - pmid:26813123 + pubmed:31346362 - a(CHEBI:rivastigmine) negativeCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:testosterone) decreases bp(GO:"programmed cell death") - pmid:19293145 + pubmed:21214928 - a(CHEBI:rivastigmine) decreases path(HBP:neurotoxicity) + a(CHEBI:testosterone) decreases path(MESH:"Plaque, Amyloid") - pmid:19293145 + pubmed:21214928 - a(CHEBI:rivastigmine) regulates act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + a(CHEBI:testosterone) decreases r(HGNC:BACE1) - pmid:24511233 + pubmed:21214928 - a(CHEBI:rivastigmine) isA a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") + a(CHEBI:testosterone) decreases p(HGNC:BACE1) - pmid:11230871 + pubmed:21214928 - a(CHEBI:rivastigmine) increases act(p(FPLX:CHRN)) + a(CHEBI:testosterone) decreases act(p(HGNC:BACE1)) - pmid:11230871 + pubmed:21214928 - a(CHEBI:rivastigmine) increases p(FPLX:CHRN) + a(CHEBI:testosterone) decreases p(HGNC:PSEN1) - pmid:29687724 + pubmed:31346362 - a(CHEBI:rivastigmine) increases bp(GO:"motor behavior") + act(p(HGNC:SIRT1)) decreases bp(GO:"programmed cell death") - pmid:29687724 + pubmed:28745240 - a(CHEBI:rivastigmine) increases path(MESH:Cognition) + p(HGNC:SIRT1) decreases act(complex(GO:"NF-kappaB complex")) - pmid:29626319 + pubmed:28745240 - a(CHEBI:rivastigmine) increases p(HGNC:ABCB1) + p(HGNC:SIRT1) decreases path(CONSO:neurotoxicity) - pmid:29626319 + pubmed:22372633 - a(CHEBI:rivastigmine) increases p(HGNC:LRP1) + p(HGNC:SIRT1) decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) - pmid:29626319 + pubmed:20869593 - a(CHEBI:rivastigmine) decreases a(CHEBI:"amyloid-beta") + p(HGNC:SIRT1) decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) - pmid:30444369 + pubmed:29540553 - a(CHEBI:memantine) increases bp(GO:cognition) + p(HGNC:SIRT1) decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 174)) - pmid:30444369 + pubmed:29540553 - a(CHEBI:memantine) decreases act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) + p(HGNC:SIRT1) decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 174)) - pmid:19293145 + pubmed:29540553 - a(CHEBI:memantine) isA a(CHEBI:"NMDA receptor antagonist") + p(HGNC:SIRT1) decreases p(HGNC:MAPT) - pmid:19293145 + pubmed:29661268 - a(CHEBI:memantine) decreases path(MESH:"Alzheimer Disease") + act(p(HGNC:SIRT1)) negativeCorrelation p(HGNC:MAPT) - pmid:23722080 + pubmed:29540553 - a(CHEBI:memantine) decreases path(MESH:"Alzheimer Disease") + p(HGNC:SIRT1) positiveCorrelation bp(GO:"learning or memory") - pmid:26813123 + pubmed:22020111 - a(CHEBI:memantine) decreases a(HBP:Excitotoxicity) + p(HGNC:SIRT1) decreases p(HGNC:NFE2L2, pmod(go:0006473 ! "protein acetylation")) - pmid:16273023 + pubmed:22179319 - a(CHEBI:memantine) decreases complex(a(CHEBI:"calcium(2+)"), p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) + p(HGNC:SIRT1) association path(MESH:Metabolism) - pmid:16273023 + pubmed:22179319 - a(CHEBI:memantine) causesNoChange bp(MESH:D009435) + p(HGNC:SIRT1) isA p(HGNCGENEFAMILY:Sirtuins) - pmid:23722080 + pubmed:22179319 - a(CHEBI:memantine) decreases p(RGD:Mapt, pmod(Ph)) + p(HGNC:SIRT1) causesNoChange p(HGNC:HTT, pmod(CONSO:"CAG repeats")) - pmid:23722080 + pubmed:22179319 - a(CHEBI:memantine) increases bp(GO:"cellular metabolic process") + p(HGNC:SIRT1) causesNoChange p(HGNC:HTT, pmod(CONSO:"CAG repeats")) - pmid:19126755 + pubmed:22179319 - act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) increases a(CHEBI:anandamide) + p(HGNC:SIRT1) decreases path(MESH:"Motor Disorders") - - - pmid:24511233 + pubmed:22179319 - p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits") regulates bp(MESH:"Neuronal Plasticity") + p(HGNC:SIRT1) decreases path(MESH:"Motor Disorders") - pmid:24511233 + pubmed:22179319 - p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits") association bp(GO:cognition) + p(HGNC:SIRT1) decreases path(MESH:"Pick Disease of the Brain") - pmid:16273023 + pubmed:22179319 - act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) decreases bp(MESH:D017774) + p(HGNC:SIRT1) decreases path(MESH:"Pick Disease of the Brain") - pmid:30444369 + pubmed:22179319 - g(HGNC:APP, var("?")) increases path(MESH:"Alzheimer Disease") + p(HGNC:SIRT1) decreases path(CONSO:Neurodegeneration) - pmid:29196815 + pubmed:22179319 - g(HGNC:APP, var("?")) increases path(MESH:"Alzheimer Disease") + p(HGNC:SIRT1) decreases path(CONSO:Neurodegeneration) - pmid:26195256 + pubmed:22179319 - g(HGNC:APP, var("?")) association path(MESH:"Alzheimer Disease") + p(HGNC:SIRT1) increases path(MESH:"Motor Activity") - pmid:30444369 + pubmed:22179319 - g(HGNC:APP, var("?")) increases bp(GO:"amyloid-beta formation") + p(HGNC:SIRT1) decreases path(MESH:Hyperglycemia) - pmid:30116051 + pubmed:22179319 - g(HGNC:APP, var("?")) decreases act(a(GO:endosome)) + p(HGNC:SIRT1) increases path(MESH:"Glucose Intolerance") - pmid:30116051 + pubmed:22179319 - g(HGNC:APP, var("?")) decreases act(a(GO:lysosome)) + p(HGNC:SIRT1) decreases path(MESH:"Weight Loss") - pmid:30116051 + pubmed:22179319 - g(HGNC:APP, var("?")) increases p(HBP:C99) + p(HGNC:SIRT1) causesNoChange path(MESH:"Energy Metabolism") - - - pmid:30444369 + pubmed:22179319 - g(HBP:"APOE e4") increases path(MESH:"Alzheimer Disease") + p(HGNC:SIRT1) decreases a(MESH:Insulins) - pmid:29758300 + pubmed:22179319 - g(HBP:"APOE e4") increases path(MESH:"Alzheimer Disease") + p(HGNC:SIRT1) increases path(MESH:"Insulin Resistance") - pmid:22908190 + pubmed:22179319 - g(HBP:"APOE e4") association path(MESH:"Alzheimer Disease") + p(HGNC:SIRT1) causesNoChange path(MESH:Longevity) - pmid:30116051 + pubmed:22179319 - g(HBP:"APOE e4") increases path(MESH:"Alzheimer Disease") + p(HGNC:SIRT1) causesNoChange a(CONSO:"huntingtin aggregates") - pmid:30444369 + pubmed:22179319 - g(HBP:"APOE e4") increases bp(GO:"amyloid-beta clearance") + p(HGNC:SIRT1) increases p(HGNC:PPP1R1B) - pmid:29758300 + pubmed:22179319 - g(HBP:"APOE e4") increases bp(GO:"cholesterol metabolic process") + p(HGNC:SIRT1) increases p(HGNC:BDNF) - pmid:29758300 + pubmed:22179319 - g(HBP:"APOE e4") regulates deg(a(CHEBI:"amyloid-beta")) + p(HGNC:SIRT1) increases p(HGNC:NTRK2, pmod(go:0006468 ! "protein phosphorylation")) - pmid:22908190 + pubmed:22179319 - g(HBP:"APOE e4") increases act(a(CHEBI:"amyloid-beta")) + p(HGNC:SIRT1) causesNoChange p(HGNC:NTRK2) - pmid:22908190 + pubmed:22179319 - g(HBP:"APOE e4") regulates bp(GO:"cholesterol transport") + p(HGNC:SIRT1) increases path(MESH:"Cell Survival") - pmid:22908190 + pubmed:22179319 - g(HBP:"APOE e4") positiveCorrelation p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") + p(HGNC:SIRT1) decreases p(HGNC:FOXO3, pmod(go:0006473 ! "protein acetylation")) - pmid:22908190 + pubmed:22179319 - g(HBP:"APOE e4") positiveCorrelation p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") + p(HGNC:SIRT1) increases p(HGNC:FOXO3) - pmid:22908190 + pubmed:30116051 - g(HBP:"APOE e4") positiveCorrelation p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") + act(p(HGNC:SIRT1)) increases act(p(HGNC:FOXO3)) - pmid:22908190 + pubmed:22179319 - g(HBP:"APOE e4") positiveCorrelation bp(GO:endocytosis) + p(HGNC:SIRT1) increases a(CHEBI:ATP) + + - pmid:22908190 + pubmed:22179319 - g(HBP:"APOE e4") increases a(GO:endosome) + p(HGNC:SIRT1) decreases p(HGNC:TP53, pmod(go:0006473 ! "protein acetylation", Lys, 382)) + + + + - pmid:22908190 + pubmed:27209302 - g(HBP:"APOE e4") positiveCorrelation tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:cytosol), toLoc(GO:lysosome)) + act(p(HGNC:SIRT1)) decreases p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation")) - pmid:30116051 + pubmed:27209302 - g(HBP:"APOE e4") increases a(CHEBI:"amyloid-beta polypeptide 42") + p(HGNC:SIRT1) decreases p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation")) - pmid:22908190 + pubmed:27209302 - g(HBP:"APOE e4") increases path(HBP:Neurodegeneration) + p(HGNC:SIRT1) directlyDecreases p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation")) - pmid:22908190 + pubmed:27209302 - g(HBP:"APOE e4") increases bp(GO:"apoptotic process") + act(p(HGNC:SIRT1), ma(GO:"deacetylase activity")) decreases p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation")) + + - pmid:30116051 + pubmed:27209302 - g(HBP:"APOE e4") increases p(HGNC:LGMN) + p(HGNC:SIRT1) decreases p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation", Lys, 116)) - pmid:27087442 + pubmed:27209302 - g(HBP:"APOE e4") increases p(MGI:Cdk5) + act(p(HGNC:SIRT1), ma(GO:"NAD+ binding")) decreases p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation", Lys, 116)) - pmid:27087442 + pubmed:27209302 - g(HBP:"APOE e4") increases p(HBP:"CDK5R1 p25") + p(HGNC:SIRT1) increases act(p(HGNC:SIRT1)) - pmid:27087442 + pubmed:27209302 - g(HBP:"APOE e4") increases p(MGI:Cdk5r1) + act(p(HGNC:SIRT1)) increases bp(GO:"microglial cell activation") - pmid:27087442 + pubmed:27209302 - g(HBP:"APOE e4") increases p(MGI:Capn1) + act(p(HGNC:SIRT1), ma(GO:"deacetylase activity")) increases bp(GO:"microglial cell activation") - pmid:27087442 + pubmed:27209302 - g(HBP:"APOE e4") increases p(MGI:Capn2) + p(HGNC:SIRT1) increases a(MESH:Lysosomes) - pmid:27087442 + pubmed:27209302 - g(HBP:"APOE e4") causesNoChange p(MGI:Gsk3b) + act(p(HGNC:SIRT1), ma(GO:"deacetylase activity")) increases a(MESH:Lysosomes) - pmid:28720530 + pubmed:27209302 - g(HBP:"APOE e4") decreases p(HGNC:PPP2R5E) + act(p(HGNC:SIRT1), ma(GO:"deacetylase activity")) increases act(a(MESH:Lysosomes)) - pmid:28720530 + pubmed:27209302 - g(HBP:"APOE e4") decreases act(p(FPLX:PPP2)) + p(HGNC:SIRT1) increases p(HGNC:TFEB) - pmid:30444369 + pubmed:27209302 - g(HGNC:PSEN1, var("?")) increases path(MESH:"Alzheimer Disease") + p(HGNC:SIRT1) increases act(p(HGNC:TFEB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) + + - pmid:29196815 + pubmed:30116051 - g(HGNC:PSEN1, var("?")) increases path(MESH:"Alzheimer Disease") + act(p(HGNC:SIRT1)) decreases act(p(FPLX:mTORC1)) - pmid:30116051 + pubmed:30116051 - g(HGNC:PSEN1, var("?")) positiveCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNC:SIRT1)) increases act(p(HGNC:FOXO1)) - pmid:26195256 + pubmed:30116051 - g(HGNC:PSEN1, var("?")) association path(MESH:"Alzheimer Disease") + act(p(HGNC:SIRT1)) increases act(p(HGNC:ATG5)) - pmid:30116051 + pubmed:30116051 - g(HGNC:PSEN1, var("?")) negativeCorrelation act(complex(GO:"lysosomal proton-transporting V-type ATPase complex")) + act(p(HGNC:SIRT1)) increases act(p(HGNC:ATG7)) - pmid:30116051 + pubmed:30116051 - g(HGNC:PSEN1, var("?")) negativeCorrelation bp(GO:autophagy) + act(p(HGNC:SIRT1)) increases act(p(HGNC:MAP1LC3A)) - pmid:30116051 + pubmed:30116051 - g(HGNC:PSEN1, var("?")) negativeCorrelation bp(GO:mitophagy) + act(p(HGNC:SIRT1)) negativeCorrelation bp(GO:aging) - - - pmid:30444369 + pubmed:26631930 - g(HGNC:PSEN2, var("?")) increases path(MESH:"Alzheimer Disease") + p(HGNC:SIRT1) decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys)) - pmid:29196815 + pubmed:20869593 - g(HGNC:PSEN2, var("?")) increases path(MESH:"Alzheimer Disease") + act(p(HGNC:SIRT1)) negativeCorrelation p(CONSO:"Tau epitope, AT8") - pmid:26195256 + pubmed:29540553 - g(HGNC:PSEN2, var("?")) association path(MESH:"Alzheimer Disease") + p(HGNC:SIRT1) decreases path(CONSO:"Pathological Tau Spreading") - + + + pubmed:29540553 + + act(p(HGNC:SIRT1)) decreases path(MESH:"Alzheimer Disease") + - + + + pubmed:29540553 + + p(HGNC:SIRT1) decreases path(MESH:"Alzheimer Disease") + - pmid:22908190 + pubmed:29540553 - p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") increases act(p(HGNC:RAB5A)) + act(p(HGNC:SIRT1)) decreases path(HP:Neurodegeneration) - pmid:22908190 + pubmed:29540553 - p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") increases act(p(HGNC:RAB5A)) + p(HGNC:SIRT1) decreases path(HP:Neurodegeneration) - pmid:22908190 + pubmed:29540553 - p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation g(HBP:"APOE e4") + p(HGNC:SIRT1) increases bp(GO:learning) - pmid:22908190 + pubmed:29540553 - p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation g(HBP:"APOE e4") + p(HGNC:SIRT1) increases bp(GO:memory) - pmid:22908190 + pubmed:29226865 - p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation g(HBP:"APOE e4") + act(p(HGNC:SIRT1)) directlyDecreases p(HGNC:SRSF2, pmod(go:0006473 ! "protein acetylation", Lys, 52)) - pmid:22908190 + pubmed:25681350 - p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation a(CHEBI:"low-density lipoprotein cholesterol") + a(PUBCHEM:14235) increases r(MGI:"chitinase-like 1") - pmid:22908190 + pubmed:25681350 - p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation a(CHEBI:"low-density lipoprotein cholesterol") + a(PUBCHEM:14235) increases r(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") - pmid:22908190 + pubmed:25681350 - p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation p(HGNC:APP) + r(MGI:"chitinase-like 1") positiveCorrelation r(MGI:"interleukin 1 alpha") - pmid:22908190 + pubmed:25681350 - p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation a(CHEBI:cholesterol) + r(MGI:"chitinase-like 1") positiveCorrelation r(MGI:"interleukin 6") - pmid:22908190 + pubmed:25681350 - p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation bp(GO:endocytosis) + r(MGI:"interleukin 1 alpha") positiveCorrelation r(MGI:"chitinase-like 1") - pmid:30012004 + pubmed:25681350 - path(HBP:"mitochondrial dysfunction") positiveCorrelation path(MESH:"Huntington Disease") + r(MGI:"interleukin 6") positiveCorrelation r(MGI:"chitinase-like 1") - pmid:21722302 + pubmed:25681350 - path(HBP:"mitochondrial dysfunction") increases bp(GO:"motor neuron apoptotic process") + p(MGI:"myelin oligodendrocyte glycoprotein", frag("35_50")) increases r(MGI:"chitinase-like 1") - pmid:29758300 + pubmed:25681350 - path(HBP:"mitochondrial dysfunction") increases path(MESH:"Alzheimer Disease") + p(MGI:"myelin oligodendrocyte glycoprotein", frag("35_50")) increases path(EFO:"experimental autoimmune encephalomyelitis") - pmid:29758300 + pubmed:25681350 - path(HBP:"mitochondrial dysfunction") increases path(MESH:"Alzheimer Disease") + p(MGI:"myelin oligodendrocyte glycoprotein", frag("35_50")) increases r(MGI:"interleukin 1 alpha") - pmid:29758300 + pubmed:25681350 - path(HBP:"mitochondrial dysfunction") decreases a(CHEBI:ATP) + p(MGI:"myelin oligodendrocyte glycoprotein", frag("35_50")) increases r(MGI:"interleukin 6") + + - pmid:29758300 + pubmed:30967783 - path(HBP:"mitochondrial dysfunction") increases a(CHEBI:"reactive oxygen species") + path(EFO:"experimental autoimmune encephalomyelitis") increases a(MESH:Monocytes, loc(GO:"node of Ranvier")) - pmid:29758300 + pubmed:30967783 - path(HBP:"mitochondrial dysfunction") increases a(CHEBI:"amyloid-beta") + path(EFO:"experimental autoimmune encephalomyelitis") increases a(MESH:Macrophages) - pmid:29758300 + pubmed:25681350 - path(HBP:"mitochondrial dysfunction") increases p(HGNC:MAPT) + p(MGI:"interleukin 1 alpha") increases complex(GO:"NF-kappaB complex") - pmid:29758300 + pubmed:25681350 - path(HBP:"mitochondrial dysfunction") increases bp(GO:mitophagy) + p(MGI:"interleukin 1 alpha") increases r(MGI:"chitinase-like 1") - pmid:28173111 + pubmed:25681350 - path(HBP:"mitochondrial dysfunction") positiveCorrelation r(MGI:Dnm1l) + p(MGI:"interleukin 1 alpha") regulates r(MGI:"chitinase-like 1") - pmid:27181519 + pubmed:25681350 - path(HBP:"mitochondrial dysfunction") increases complex(GO:"cytoplasmic stress granule") + p(MGI:"interleukin 1 alpha") increases r(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") - + + + pubmed:25681350 + + p(MGI:"interleukin 1 alpha") increases act(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B")) + - pmid:30444369 + pubmed:25681350 - complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases act(p(HGNC:HSD17B10)) + p(MGI:"interleukin 1 alpha") increases act(complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105"))) - pmid:30444369 + pubmed:25681350 - complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases path(MESH:"Alzheimer Disease") + p(MGI:"interleukin 1 alpha") increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) - pmid:30444369 + pubmed:25681350 - complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases bp(GO:"response to oxidative stress") + act(p(MGI:"interleukin 1 alpha")) increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) - pmid:30444369 + pubmed:25681350 - complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases a(CHEBI:"reactive oxygen species") + p(MGI:"interleukin 1 alpha") increases path(MESH:Glioblastoma) - pmid:30444369 + pubmed:25681350 - complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases a(CHEBI:"reactive oxygen species") + p(MGI:"interleukin 1 alpha") increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"chitinase-like 1"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) + + - pmid:30444369 + pubmed:25681350 - complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases bp(GO:"apoptotic DNA fragmentation") + p(MGI:"interleukin 1 alpha") increases act(p(MGI:"signal transducer and activator of transcription 3")) - pmid:30444369 + pubmed:25681350 - complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases bp(GO:"neuron death") + p(MGI:"interleukin 1 alpha") increases p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105") - pmid:30444369 + pubmed:28745240 - complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases bp(GO:learning) + complex(GO:"NF-kappaB complex") increases bp(MESH:"Synaptic Transmission") - pmid:30444369 + pubmed:28745240 - complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases act(p(FPLX:COX)) + complex(GO:"NF-kappaB complex") increases bp(MESH:"Synaptic Transmission") - pmid:30444369 + pubmed:25652642 - complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases bp(GO:"regulation of mitochondrial membrane potential") + act(complex(GO:"NF-kappaB complex")) increases bp(MESH:"Synaptic Transmission") - pmid:30444369 + pubmed:28745240 - complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases a(CHEBI:ATP) + act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"neuron death") - pmid:30444369 + pubmed:28745240 - complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases sec(a(PUBCHEM:16057918)) + complex(GO:"NF-kappaB complex") decreases bp(GO:"neuron death") - pmid:30444369 + pubmed:28745240 - complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases act(p(HGNC:CASP3)) + complex(GO:"NF-kappaB complex") decreases bp(GO:"neuron death") - pmid:30444369 + pubmed:28745240 - complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases bp(GO:"apoptotic process") + act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"neuron death") - pmid:30444369 + pubmed:25652642 - complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases complex(a(CHEBI:"NAD(+)"), p(HGNC:HSD17B10)) + act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"neuron death") - pmid:30444369 + pubmed:28745240 - p(HGNC:HSD17B10) positiveCorrelation path(MESH:"Alzheimer Disease") + complex(GO:"NF-kappaB complex") increases bp(GO:"positive regulation of synaptic plasticity") - pmid:30444369 + pubmed:25652642 - act(p(HGNC:HSD17B10)) increases rxn(reactants(a(PUBCHEM:440326)), products(a(PUBCHEM:193425))) + act(complex(GO:"NF-kappaB complex")) increases bp(GO:"positive regulation of synaptic plasticity") - pmid:30444369 + pubmed:28745240 - act(p(HGNC:HSD17B10)) increases rxn(reactants(a(CHEBI:"NAD(+)"), a(PUBCHEM:9543037)), products(a(CHEBI:"3-oxo-fatty acyl-CoA(4-)"), a(CHEBI:NADH), a(PUBCHEM:1038))) + complex(GO:"NF-kappaB complex") regulates bp(GO:cognition) - pmid:30444369 + pubmed:28745240 - act(p(HGNC:HSD17B10)) increases rxn(reactants(a(PUBCHEM:15818)), products(a(PUBCHEM:10635))) + complex(GO:"NF-kappaB complex") regulates bp(GO:behavior) - pmid:30444369 + pubmed:28745240 - act(p(HGNC:HSD17B10)) increases rxn(reactants(a(PUBCHEM:5757)), products(a(PUBCHEM:5870))) + complex(GO:"NF-kappaB complex") increases path(MESH:"Spatial Memory") - pmid:30444369 + pubmed:25652642 - act(p(HGNC:HSD17B10)) association p(HGNCGENEFAMILY:"Gamma-aminobutyric acid type A receptor subunits") + act(complex(GO:"NF-kappaB complex")) increases path(MESH:"Spatial Memory") - - - - - - - - - - - + + + pubmed:28745240 + + complex(GO:"NF-kappaB complex") increases bp(GO:memory) + - pmid:30116051 + pubmed:28745240 - a(CHEBI:"NAD(+)") increases act(p(HGNC:SIRT1)) + complex(GO:"NF-kappaB complex") increases bp(GO:learning) - pmid:30116051 + pubmed:28745240 - a(CHEBI:"NAD(+)") increases act(p(HGNC:SIRT1)) + complex(GO:"NF-kappaB complex") increases act(p(HGNC:PRKACA)) - + + + pubmed:28745240 + + complex(GO:"NF-kappaB complex") decreases p(HGNC:BCL2L1) + - + + + pubmed:28745240 + + complex(GO:"NF-kappaB complex") increases p(HGNC:BCL2L1) + - pmid:30444369 + pubmed:28745240 - a(PUBCHEM:5757) decreases a(HBP:"amyloid-beta aggregates") + complex(GO:"NF-kappaB complex") decreases tloc(a(PUBCHEM:16057918), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:30444369 + pubmed:28745240 - a(PUBCHEM:5757) decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + complex(GO:"NF-kappaB complex") regulates r(HGNC:BCL2L1) - pmid:30444369 + pubmed:28745240 - a(PUBCHEM:5757) decreases act(p(HGNC:GSK3B)) + complex(GO:"NF-kappaB complex") decreases bp(GO:"apoptotic process") - pmid:30444369 + pubmed:28745240 - a(PUBCHEM:5757) increases p(HGNC:GSK3B, pmod(Ph)) + complex(GO:"NF-kappaB complex") decreases bp(GO:"apoptotic process") - pmid:30444369 + pubmed:25652642 - a(PUBCHEM:5757) increases p(HGNC:BCL2) + act(complex(GO:"NF-kappaB complex"), ma(GO:"DNA binding")) decreases bp(GO:"apoptotic process") - pmid:30444369 + pubmed:25652642 - a(PUBCHEM:5757) increases p(HGNC:BCL2L1) + act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"apoptotic process") - pmid:30444369 + pubmed:28745240 - a(PUBCHEM:5757) decreases p(HGNC:BCL2L11) + complex(GO:"NF-kappaB complex") increases p(HGNC:BCL2) - pmid:30444369 + pubmed:28745240 - a(PUBCHEM:5757) increases p(HGNC:SOD2) + complex(GO:"NF-kappaB complex") increases p(HGNC:BCL2A1) - pmid:30444369 + pubmed:28745240 - a(PUBCHEM:5757) increases p(FPLX:GPX) + act(complex(GO:"NF-kappaB complex")) decreases act(a(MESH:"Amyloid beta-Peptides")) - pmid:30444369 + pubmed:28745240 - p(HGNCGENEFAMILY:"Gamma-aminobutyric acid type A receptor subunits") association act(p(HGNC:HSD17B10)) + act(complex(GO:"NF-kappaB complex")) increases r(HGNC:SOD2) - pmid:30444369 + pubmed:28745240 - act(p(HGNCGENEFAMILY:"Gamma-aminobutyric acid type A receptor subunits")) positiveCorrelation a(PUBCHEM:101790) + act(complex(GO:"NF-kappaB complex")) decreases p(MESH:Proteins, pmod(CONSO:nitration)) + + + + - pmid:30444369 + pubmed:28745240 - act(p(HGNCGENEFAMILY:"Gamma-aminobutyric acid type A receptor subunits")) positiveCorrelation a(PUBCHEM:92786) + act(complex(GO:"NF-kappaB complex")) increases bp(GO:neurogenesis) - pmid:30444369 + pubmed:28745240 - a(PUBCHEM:101790) positiveCorrelation act(p(HGNCGENEFAMILY:"Gamma-aminobutyric acid type A receptor subunits")) + act(complex(GO:"NF-kappaB complex")) increases bp(GO:neurogenesis) - pmid:30444369 + pubmed:28745240 - a(PUBCHEM:92786) positiveCorrelation act(p(HGNCGENEFAMILY:"Gamma-aminobutyric acid type A receptor subunits")) + act(complex(GO:"NF-kappaB complex")) increases bp(GO:neurogenesis) - pmid:30444369 + pubmed:28745240 - a(CHEBI:"methylene blue") decreases complex(p(HGNC:APP), p(HGNC:HSD17B10)) + complex(GO:"NF-kappaB complex") regulates a(MESH:"Neural Stem Cells") - pmid:30444369 + pubmed:28745240 - a(CHEBI:"methylene blue") decreases path(HBP:"mitochondrial dysfunction") + act(complex(GO:"NF-kappaB complex")) negativeCorrelation a(MESH:"Cerebral Cortex") - pmid:30444369 + pubmed:28745240 - a(CHEBI:"methylene blue") decreases p(HGNC:HSD17B10) + act(complex(GO:"NF-kappaB complex")) increases bp(GO:"stem cell division") - pmid:30444369 + pubmed:28745240 - a(CHEBI:"methylene blue") decreases a(HBP:"amyloid-beta aggregates") + complex(GO:"NF-kappaB complex") increases p(HGNC:IL6) - pmid:29758300 + pubmed:28745240 - a(CHEBI:"methylene blue") decreases p(HGNC:MAPT, pmod(HBP:misfolding)) + complex(GO:"NF-kappaB complex") increases p(HGNC:IL6) - pmid:29758300 + pubmed:28745240 - a(CHEBI:"methylene blue") increases bp(GO:macroautophagy) + complex(GO:"NF-kappaB complex") increases p(HGNC:IL6) - pmid:30116051 + pubmed:28745240 - a(CHEBI:"methylene blue") increases bp(GO:macroautophagy) + complex(GO:"NF-kappaB complex") increases p(HGNC:IL6) - pmid:29758300 + pubmed:25652642 - a(CHEBI:"methylene blue") increases p(HGNC:BECN1) + complex(GO:"NF-kappaB complex") increases p(HGNC:IL6) - pmid:30116051 + pubmed:28745240 - a(CHEBI:"methylene blue") increases p(HGNC:BECN1) + act(complex(GO:"NF-kappaB complex")) increases bp(GO:"astrocyte development") - pmid:29758300 + pubmed:28745240 - a(CHEBI:"methylene blue") increases p(HGNC:MAP1LC3B) + complex(GO:"NF-kappaB complex") increases p(HGNC:LIF) - pmid:29758300 + pubmed:28745240 - a(CHEBI:"methylene blue") decreases p(HGNC:MAPT) + complex(GO:"NF-kappaB complex") increases p(HGNC:CNTF) - pmid:30116051 + pubmed:28745240 - a(CHEBI:"methylene blue") decreases act(p(HGNC:MAPT)) + act(complex(GO:"NF-kappaB complex")) increases bp(GO:"dendritic spine organization") - pmid:23528736 + pubmed:28745240 - a(CHEBI:"methylene blue") decreases p(HGNC:MAPT) + act(complex(GO:"NF-kappaB complex")) increases bp(MESH:"Neuronal Outgrowth") - pmid:29758300 + pubmed:28745240 - a(CHEBI:"methylene blue") decreases p(HGNC:SQSTM1) + act(complex(GO:"NF-kappaB complex")) increases bp(MESH:"Neuronal Outgrowth") - pmid:30116051 + pubmed:28745240 - a(CHEBI:"methylene blue") increases p(HGNC:SQSTM1) + act(complex(GO:"NF-kappaB complex")) increases bp(MESH:"Neuronal Outgrowth") - pmid:30116051 + pubmed:28745240 - a(CHEBI:"methylene blue") decreases a(HBP:"Tau oligomers") + act(complex(GO:"NF-kappaB complex")) increases bp(MESH:"Neuronal Outgrowth") - pmid:30116051 + pubmed:28745240 - a(CHEBI:"methylene blue") increases bp(GO:autophagy) + act(complex(GO:"NF-kappaB complex")) increases a(GO:axon) - pmid:23528736 + pubmed:28745240 - a(CHEBI:"methylene blue") increases bp(GO:autophagy) + act(complex(GO:"NF-kappaB complex")) increases bp(GO:"axon guidance") - pmid:29626319 + pubmed:28745240 - a(CHEBI:"methylene blue") increases bp(GO:autophagy) + complex(GO:"NF-kappaB complex") regulates r(HGNC:ITGB1) - pmid:30116051 + pubmed:28745240 - a(CHEBI:"methylene blue") increases act(p(FPLX:AMPK)) + complex(GO:"NF-kappaB complex") regulates p(HGNC:NCAM1) - pmid:30116051 + pubmed:28745240 - a(CHEBI:"methylene blue") increases p(HGNC:MAP1LC3A) + complex(GO:"NF-kappaB complex") regulates p(HGNC:SLITRK1) - pmid:24027553 + pubmed:28745240 - a(CHEBI:"methylene blue") increases bp(MESH:Autophagy) + complex(GO:"NF-kappaB complex") regulates p(HGNC:GFRA1) - pmid:24027553 + pubmed:28745240 - a(CHEBI:"methylene blue") increases bp(MESH:Autophagy) + complex(GO:"NF-kappaB complex") regulates p(HGNC:TIAM1) - pmid:22611162 + pubmed:28745240 - a(CHEBI:"methylene blue") increases bp(GO:locomotion) + act(complex(GO:"NF-kappaB complex")) increases a(MESH:"Dendritic Cells") - pmid:29191965 + pubmed:28745240 - a(CHEBI:"methylene blue") increases bp(GO:locomotion) + act(complex(GO:"NF-kappaB complex")) increases a(GO:"dendritic branch") - pmid:22611162 + pubmed:28745240 - a(CHEBI:"methylene blue") decreases a(HBP:"Tau aggregates") + act(complex(GO:"NF-kappaB complex")) increases r(HGNC:HES1) - pmid:23528736 + pubmed:28745240 - a(CHEBI:"methylene blue") decreases a(HBP:"Tau aggregates") + act(complex(GO:"NF-kappaB complex")) increases r(HGNC:HES5) - pmid:29191965 + pubmed:28745240 - a(CHEBI:"methylene blue") decreases a(HBP:"Tau aggregates") + complex(GO:"NF-kappaB complex") increases p(HGNC:MAP1B) - pmid:23528736 + pubmed:28745240 - a(CHEBI:"methylene blue") decreases p(HGNC:MAPT, pmod(Ph)) + complex(GO:"NF-kappaB complex") increases p(HGNC:MAP2) - pmid:23528736 + pubmed:28745240 - a(CHEBI:"methylene blue") increases bp(GO:cognition) + complex(GO:"NF-kappaB complex") regulates p(HGNC:C3) - pmid:21882945 + pubmed:28745240 - a(CHEBI:"methylene blue") decreases act(p(INTERPRO:"Heat shock protein 70 family")) + complex(GO:"NF-kappaB complex") regulates p(HGNC:CFB) - pmid:26751493 + pubmed:28745240 - a(CHEBI:"methylene blue") decreases p(HBP:"Tau aggregates") + complex(GO:"NF-kappaB complex") regulates p(HGNC:CR2) - pmid:26751493 + pubmed:28745240 - a(CHEBI:"methylene blue") increases bp(GO:"protein catabolic process") + complex(GO:"NF-kappaB complex") regulates p(HGNC:C4A) - pmid:26751493 + pubmed:28745240 - a(CHEBI:"methylene blue") association bp(GO:"response to oxidative stress") + complex(GO:"NF-kappaB complex") regulates p(HGNC:C4BPA) - pmid:26751493 + pubmed:28745240 - a(CHEBI:"methylene blue") decreases act(p(HGNC:CASP1)) + complex(GO:"NF-kappaB complex") regulates p(HGNC:IL1B) - pmid:26751493 + pubmed:28745240 - a(CHEBI:"methylene blue") decreases act(p(HGNC:CASP3)) + complex(GO:"NF-kappaB complex") increases p(HGNC:IL1B) - pmid:26751493 + pubmed:25652642 - a(CHEBI:"methylene blue") increases bp(GO:"energy reserve metabolic process") + complex(GO:"NF-kappaB complex") increases p(HGNC:IL1B) - pmid:26751493 + pubmed:28745240 - a(CHEBI:"methylene blue") isA a(CHEBI:antioxidant) + complex(GO:"NF-kappaB complex") increases act(p(HGNC:IL1A)) - pmid:27708431 + pubmed:28745240 - a(CHEBI:"methylene blue") decreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + complex(GO:"NF-kappaB complex") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) - pmid:27708431 + pubmed:28745240 - a(CHEBI:"methylene blue") decreases act(p(HGNC:MARK4), ma(kin)) + complex(GO:"NF-kappaB complex") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) - pmid:27708431 + pubmed:28745240 - a(CHEBI:"methylene blue") increases deg(p(HGNC:MARK4)) + complex(GO:"NF-kappaB complex") increases act(complex(p(HGNC:CDK5), p(HGNC:CDK5R1))) - pmid:27708431 + pubmed:28745240 - a(CHEBI:"methylene blue") increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + complex(GO:"NF-kappaB complex") regulates p(HGNC:TNF) - pmid:28287136 + pubmed:28745240 - a(CHEBI:"methylene blue") decreases p(HGNC:MAPT, pmod(Ac)) + complex(GO:"NF-kappaB complex") increases p(HGNC:TNF) - pmid:25437566 + pubmed:28745240 - a(CHEBI:ATP) association act(p(FPLX:HSP90)) + complex(GO:"NF-kappaB complex") increases p(HGNC:TNF) - pmid:23746257 + pubmed:25652642 - a(CHEBI:ATP) regulates act(p(FPLX:HSP90)) + complex(GO:"NF-kappaB complex") increases p(HGNC:TNF) - pmid:25437566 + pubmed:28745240 - a(CHEBI:ATP) association act(p(FPLX:HSPA)) + act(complex(GO:"NF-kappaB complex")) increases tloc(a(CHEBI:amyloid-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:23746257 + pubmed:28745240 - a(CHEBI:ATP) regulates act(p(FPLX:HSPA)) + act(complex(GO:"NF-kappaB complex")) increases a(CHEBI:amyloid-beta) - pmid:25437566 + pubmed:28745240 - a(CHEBI:ATP) association act(p(HGNC:HSPD1)) + complex(GO:"NF-kappaB complex") regulates a(CHEBI:amyloid-beta) - pmid:23746257 + pubmed:28745240 - a(CHEBI:ATP) regulates act(p(HGNCGENEFAMILY:Chaperonins)) + complex(GO:"NF-kappaB complex") regulates a(CHEBI:amyloid-beta) - pmid:23746257 + pubmed:25652642 - a(CHEBI:ATP) causesNoChange act(p(FPLX:HSPB)) + act(complex(GO:"NF-kappaB complex")) regulates a(CHEBI:amyloid-beta) - pmid:23746257 + pubmed:25652642 - a(CHEBI:ATP) regulates complex(p(HGNC:HSPD1), p(HGNC:HSPE1)) + act(complex(GO:"NF-kappaB complex")) positiveCorrelation a(CHEBI:amyloid-beta) - pmid:24457024 + pubmed:28745240 - a(CHEBI:ATP) decreases complex(a(MESH:Proteins), a(MESH:Ubiquitin)) + complex(GO:"NF-kappaB complex") increases r(HGNC:BACE1) - pmid:24457024 + pubmed:28745240 - a(CHEBI:ATP) increases tloc(a(MESH:Proteins), fromLoc(GO:cytosol), toLoc(HBP:"20 S Proteasome")) + complex(GO:"NF-kappaB complex") increases r(HGNC:BACE1) - pmid:27671637 + pubmed:21958873 - a(CHEBI:ATP) positiveCorrelation a(GO:mitochondrion) + complex(GO:"NF-kappaB complex") regulates r(HGNC:BACE1) - pmid:19251756 + pubmed:25331948 - a(CHEBI:ATP) negativeCorrelation path(MESH:"Alzheimer Disease") + complex(GO:"NF-kappaB complex") regulates r(HGNC:BACE1) - pmid:24561250 + pubmed:28745240 - a(CHEBI:ATP) increases act(complex(GO:"inflammasome complex")) + complex(GO:"NF-kappaB complex") regulates bp(CONSO:"APP processing") - pmid:24561250 + pubmed:25652642 - a(CHEBI:ATP) increases act(complex(GO:"inflammasome complex")) + act(complex(GO:"NF-kappaB complex")) decreases bp(CONSO:"APP processing") - pmid:24561250 + pubmed:25652642 - a(CHEBI:ATP) increases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) + act(complex(GO:"NF-kappaB complex")) positiveCorrelation bp(CONSO:"APP processing") - pmid:24561250 + pubmed:28745240 - a(CHEBI:ATP) increases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) + complex(GO:"NF-kappaB complex") regulates p(CONSO:C99) - pmid:24561250 + pubmed:28745240 - a(CHEBI:ATP) increases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) + complex(GO:"NF-kappaB complex") regulates act(complex(GO:"gamma-secretase complex")) - pmid:24561250 + pubmed:28745240 - a(CHEBI:ATP) increases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) + complex(GO:"NF-kappaB complex") increases act(complex(GO:"gamma-secretase complex")) - pmid:21722302 + pubmed:28745240 - p(HGNC:CASP3) increases bp(MESH:"Cell Death") + complex(GO:"NF-kappaB complex") regulates p(HGNC:PSEN1) - pmid:29758300 + pubmed:28745240 - p(HGNC:CASP3) increases p(HGNC:BECN1, frag("?")) + complex(GO:"NF-kappaB complex") regulates p(HGNC:APP) - pmid:30116051 + pubmed:28745240 - act(p(HGNC:CASP3)) increases p(HGNC:BECN1, frag("?")) + complex(GO:"NF-kappaB complex") regulates p(HGNC:APP) - pmid:24027553 + pubmed:25652642 - act(p(HGNC:CASP3)) increases p(HGNC:MAPT, frag("?_*")) + act(complex(GO:"NF-kappaB complex")) regulates p(HGNC:APP) - pmid:24027553 + pubmed:28745240 - act(p(HGNC:CASP3)) increases deg(p(HGNC:MAPT)) + act(complex(GO:"NF-kappaB complex")) increases p(HGNC:SOD2) - pmid:24027553 + pubmed:25652642 - act(p(HGNC:CASP3)) increases p(HBP:"Tau C3") + act(complex(GO:"NF-kappaB complex")) increases act(p(HGNC:SOD2)) - pmid:24027553 + pubmed:28745240 - act(p(HGNC:CASP3)) increases p(HBP:"Tau C3") + act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"calcium ion homeostasis") - pmid:24027553 + pubmed:28745240 - act(p(HGNC:CASP3)) positiveCorrelation path(MESH:"Alzheimer Disease") + complex(GO:"NF-kappaB complex") increases p(HGNC:CXCL8) @@ -46120,105 +46517,99 @@

Statements

- pmid:26631930 + pubmed:25652642 - p(HGNC:CASP3) increases p(HGNC:MAPT, frag("?")) + act(complex(GO:"NF-kappaB complex")) increases bp(GO:"inflammatory response") - pmid:26631930 + pubmed:25652642 - p(HGNC:CASP3) increases p(HGNC:MAPT, frag("1_421")) + act(complex(GO:"NF-kappaB complex")) increases a(MESH:"Free Radicals") - pmid:29238289 + pubmed:25652642 - act(p(HGNC:CASP3)) increases rxn(reactants(p(HGNC:MAPT)), products(p(HGNC:MAPT, frag("1_421")), p(HGNC:MAPT, frag("421_*")))) + act(complex(GO:"NF-kappaB complex")) positiveCorrelation a(GO:"neurofibrillary tangle") - pmid:27068745 + pubmed:25652642 - p(HGNC:CASP3) association act(p(FPLX:JNK)) + act(complex(GO:"NF-kappaB complex")) positiveCorrelation path(MESH:"Plaque, Amyloid") - pmid:27068745 + pubmed:25652642 - p(HGNC:CASP3) association act(p(HGNC:MAP3K5)) + complex(GO:"NF-kappaB complex") association path(MESH:"Plaque, Amyloid") - pmid:27068745 + pubmed:25652642 - p(HGNC:CASP3) increases bp(GO:"neuron apoptotic process") + act(complex(GO:"NF-kappaB complex")) regulates p(HGNC:BACE1) - pmid:27314526 + pubmed:25652642 - act(p(HGNC:CASP3)) increases bp(GO:"neuron death") + act(complex(GO:"NF-kappaB complex")) decreases p(HGNC:BACE1) - - - - - pmid:30444369 + pubmed:25331948 - p(HGNC:BCL2L11) increases bp(GO:"apoptotic process") + complex(GO:"NF-kappaB complex") regulates p(HGNC:BACE1) - - - pmid:23528736 + pubmed:25652642 - p(HGNC:BCL2L11) decreases bp(GO:autophagy) + act(complex(GO:"NF-kappaB complex")) decreases p(CONSO:sAPP-beta) - pmid:30444369 + pubmed:25652642 - act(p(HGNC:PRDX2)) negativeCorrelation path(MESH:"Alzheimer Disease") + act(complex(GO:"NF-kappaB complex")) positiveCorrelation p(CONSO:sAPP-beta) - pmid:30444369 + pubmed:25652642 - p(HGNC:PRDX2) positiveCorrelation path(MESH:"Alzheimer Disease") + complex(GO:"NF-kappaB complex") association act(p(HGNC:APOE)) @@ -46227,1227 +46618,1315 @@

Statements

- pmid:30444369 + pubmed:25652642 - p(HGNC:PRDX2, pmod(Ph, Thr, 89)) decreases act(p(HGNC:PRDX2)) + complex(GO:"NF-kappaB complex") increases bp(MESH:Neuroprotection) - pmid:30444369 + pubmed:25652642 - p(HGNC:SH3GL2) increases bp(GO:"synaptic vesicle endocytosis") + complex(GO:"NF-kappaB complex") regulates bp(MESH:Neuroprotection) - pmid:30444369 + pubmed:25652642 - p(HGNC:SH3GL2) positiveCorrelation path(MESH:"Alzheimer Disease") + act(complex(GO:"NF-kappaB complex")) decreases a(CHEBI:peroxynitrite) - pmid:30444369 + pubmed:25652642 - p(HGNC:SH3GL2) increases act(p(HGNC:MAP3K1)) + act(complex(GO:"NF-kappaB complex")) decreases bp(GO:"membrane depolarization") - pmid:30444369 + pubmed:25652642 - p(HGNC:SH3GL2) association bp(GO:"neuron projection development") + act(complex(GO:"NF-kappaB complex")) decreases a(MESH:"Cholinergic Neurons") - pmid:30444369 + pubmed:25652642 - p(HGNC:SH3GL2) association bp(GO:"regulation of synaptic plasticity") + act(complex(GO:"NF-kappaB complex")) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:30444369 + pubmed:25652642 - p(HGNC:SH3GL2) association bp(GO:"neuron death") + complex(GO:"NF-kappaB complex") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:30444369 + pubmed:25652642 - act(p(HGNC:MAP3K1)) increases bp(GO:"JNK cascade") + complex(GO:"NF-kappaB complex") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:30444369 + pubmed:25652642 - bp(GO:"neuron projection development") association p(HGNC:SH3GL2) + act(complex(GO:"NF-kappaB complex")) increases act(a(MESH:Microglia)) - pmid:20133804 + pubmed:25652642 - bp(GO:"neuron projection development") negativeCorrelation p(RGD:Fkbp4) + act(complex(GO:"NF-kappaB complex")) increases act(a(MESH:Cytokines)) - pmid:30444369 + pubmed:25652642 - a(HBP:AG18051) decreases act(p(HGNC:HSD17B10)) + act(complex(GO:"NF-kappaB complex")) increases act(a(CHEBI:"glutamate(1-)")) - pmid:30444369 + pubmed:25652642 - a(HBP:AG18051) decreases act(a(HBP:"amyloid-beta aggregates")) + act(complex(GO:"NF-kappaB complex")) increases act(a(CHEBI:"reactive oxygen species")) - pmid:30444369 + pubmed:25652642 - a(HBP:"RM-532-46") decreases act(p(HGNC:HSD17B10)) + act(complex(GO:"NF-kappaB complex")) increases act(a(CHEBI:"reactive oxygen species")) - pmid:30444369 + pubmed:25652642 - a(PUBCHEM:33334) decreases complex(p(HGNC:APP), p(HGNC:HSD17B10)) + act(complex(GO:"NF-kappaB complex")) increases act(p(HGNC:NOS2)) - pmid:30444369 + pubmed:25652642 - a(PUBCHEM:33334) decreases act(p(HGNC:CSNK1A1)) + act(complex(GO:"NF-kappaB complex")) increases act(p(HGNC:NOS2)) - pmid:30444369 + pubmed:25652642 - p(HGNC:CSNK1A1) increases p(HGNC:MAPT, pmod(Ph)) + act(complex(GO:"NF-kappaB complex")) increases path(CONSO:neurotoxicity) - pmid:30444369 + pubmed:25652642 - p(HGNC:CSNK1A1) regulates act(p(FPLX:"Gamma_secretase")) + complex(GO:"NF-kappaB complex") regulates m(HGNC:MIR9-1) - pmid:30444369 + pubmed:25652642 - p(HGNC:CSNK1A1) increases bp(GO:"amyloid-beta formation") + complex(GO:"NF-kappaB complex") regulates m(HGNC:MIR34A) - pmid:25974414 + pubmed:25652642 - act(p(HGNC:CSNK1A1), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + complex(GO:"NF-kappaB complex") regulates m(HGNC:MIR125B1) - pmid:25673844 + pubmed:25652642 - p(HGNC:CSNK1A1) isA p(FPLX:CSNK1) + complex(GO:"NF-kappaB complex") regulates m(HGNC:MIR146A) - pmid:25546293 + pubmed:25652642 - p(HGNC:CSNK1A1) increases p(HGNC:CTNNB1, pmod(Ph, Ser, 45)) + complex(GO:"NF-kappaB complex") regulates m(HGNC:MIR155) - + + + pubmed:25652642 + + complex(GO:"NF-kappaB complex") regulates m(HGNC:MIR339) + - pmid:30444369 + pubmed:21958873 - composite(a(PUBCHEM:208907), a(PUBCHEM:33334)) decreases act(p(HGNC:MAOA)) + complex(GO:"NF-kappaB complex") regulates p(HGNC:CRP) - pmid:30061532 + pubmed:25681350 - path(MESH:"Neurodegenerative Diseases") positiveCorrelation act(p(HGNC:MTOR)) + p(MGI:"oncostatin M") increases p(MGI:"signal transducer and activator of transcription 3") - pmid:22040696 + pubmed:25681350 - path(MESH:"Neurodegenerative Diseases") association p(HGNC:CHRNA7) + p(MGI:"oncostatin M") increases act(p(MGI:"signal transducer and activator of transcription 3")) - pmid:29687724 + pubmed:25681350 - path(MESH:"Neurodegenerative Diseases") association path(MESH:"Huntington Disease") + p(MGI:"oncostatin M") increases act(p(MGI:"signal transducer and activator of transcription 3")) - pmid:21722302 + pubmed:25681350 - path(MESH:"Neurodegenerative Diseases") association bp(HBP:"protein aggregation") + p(MGI:"oncostatin M") increases r(MGI:"chitinase-like 1") - pmid:21722302 + pubmed:25681350 - path(MESH:"Neurodegenerative Diseases") association bp(HBP:"protein aggregation") + p(MGI:"oncostatin M") regulates r(MGI:"chitinase-like 1") - pmid:21722302 + pubmed:25681350 - path(MESH:"Neurodegenerative Diseases") association bp(MESH:"Endoplasmic Reticulum Stress") + p(MGI:"oncostatin M") increases r(MGI:"chitinase-like 1") - pmid:21722302 + pubmed:25681350 - path(MESH:"Neurodegenerative Diseases") association path(HP:"Senile plaques") + p(MGI:"oncostatin M") increases path(MESH:Glioblastoma) + + - pmid:21722302 + pubmed:25681350 - path(MESH:"Neurodegenerative Diseases") association bp(MESH:"Unfolded Protein Response") + p(MGI:"oncostatin M") increases complex(p(MGI:"chitinase-like 1"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) - pmid:29758300 + pubmed:25681350 - path(MESH:"Neurodegenerative Diseases") positiveCorrelation a(HBP:"protein aggregates") + p(MGI:"oncostatin M") increases act(p(MGI:"interleukin 1 alpha")) - pmid:29758300 + pubmed:25681350 - path(MESH:"Neurodegenerative Diseases") association bp(GO:"neuron death") + p(MGI:"oncostatin M") increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) - pmid:22908190 + pubmed:25681350 - path(MESH:"Neurodegenerative Diseases") association bp(GO:"regulation of endosome size") + p(MGI:"signal transducer and activator of transcription 3") association p(MGI:"chitinase-like 1") - pmid:25784053 + pubmed:25681350 - path(MESH:"Neurodegenerative Diseases") association path(MESH:"Protein Aggregation, Pathological") + p(MGI:"signal transducer and activator of transcription 3") increases r(MGI:"chitinase-like 1") - pmid:18930136 + pubmed:25681350 - path(MESH:"Neurodegenerative Diseases") positiveCorrelation p(MESH:Proteins, pmod(HBP:misfolding)) + p(MGI:"signal transducer and activator of transcription 3") increases r(MGI:"chitinase-like 1") - pmid:18930136 + pubmed:25681350 - path(MESH:"Neurodegenerative Diseases") association bp(GO:autophagy) + act(p(MGI:"signal transducer and activator of transcription 3")) increases act(p(MGI:"interleukin 1 alpha")) - pmid:18930136 + pubmed:25681350 - path(MESH:"Neurodegenerative Diseases") negativeCorrelation bp(GO:autophagy) + act(p(MGI:"signal transducer and activator of transcription 3")) increases act(p(MGI:"oncostatin M")) - pmid:29024336 + pubmed:25681350 - path(MESH:"Neurodegenerative Diseases") increases path(MESH:"Proteostasis Deficiencies") + p(MGI:"v-rel reticuloendotheliosis viral oncogene homolog A (avian)") association p(MGI:"chitinase-like 1") - pmid:29024336 + pubmed:25681350 - path(MESH:"Neurodegenerative Diseases") increases path(MESH:"Proteostasis Deficiencies") + p(MGI:"v-rel reticuloendotheliosis viral oncogene homolog A (avian)") causesNoChange p(MGI:"chitinase-like 1") - pmid:24027553 + pubmed:25681350 - path(MESH:"Neurodegenerative Diseases") association p(HGNCGENEFAMILY:Calpains) + p(MGI:"v-rel reticuloendotheliosis viral oncogene homolog A (avian)") decreases r(MGI:"chemokine (C-X-C motif) ligand 15") - pmid:23528736 + pubmed:25681350 - path(MESH:"Neurodegenerative Diseases") association p(HGNC:STUB1) + p(MGI:"v-rel reticuloendotheliosis viral oncogene homolog A (avian)") causesNoChange r(MGI:"chitinase-like 1") - pmid:23528736 + pubmed:25681350 - path(MESH:"Neurodegenerative Diseases") association p(HGNC:PRKN) + p(MGI:"chitinase-like 1") association p(MGI:"v-rel reticuloendotheliosis viral oncogene homolog A (avian)") - pmid:23528736 + pubmed:25681350 - path(MESH:"Neurodegenerative Diseases") association p(HGNC:RNF182) + p(MGI:"chitinase-like 1") association p(MGI:"signal transducer and activator of transcription 3") + + - pmid:23528736 + pubmed:25681350 - path(MESH:"Neurodegenerative Diseases") association p(HGNC:UCHL1, var("?")) + p(MGI:"chitinase-like 1") increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"chitinase-like 1"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) + + - pmid:23528736 + pubmed:25681350 - path(MESH:"Neurodegenerative Diseases") association p(HGNC:ATXN3, var("?")) + p(MGI:"chitinase-like 1") increases complex(a(GO:"NF-kappaB p50/p65 complex"), p(MGI:"chitinase-like 1")) + + - pmid:29191965 + pubmed:25681350 - path(MESH:"Neurodegenerative Diseases") association bp(GO:"aggresome assembly") + p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha", var("?")) decreases act(p(MGI:"interleukin 1 alpha")) - pmid:29311797 + pubmed:25681350 - path(MESH:"Neurodegenerative Diseases") association bp(MESH:Aging) + p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha", var("?")) decreases act(p(MGI:"oncostatin M")) + + - pmid:29311797 + pubmed:25681350 - path(MESH:"Neurodegenerative Diseases") negativeCorrelation act(p(FPLX:Proteasome)) + p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") increases r(MGI:"chitinase-like 1") - pmid:29311797 + pubmed:25681350 - path(MESH:"Neurodegenerative Diseases") negativeCorrelation bp(GO:"chaperone-mediated autophagy") + p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") regulates p(MGI:"chitinase-like 1") - pmid:26702100 + pubmed:25681350 - path(MESH:"Neurodegenerative Diseases") association p(HGNC:TFEB) + p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") regulates p(MGI:"chitinase-like 1") - pmid:29196815 + pubmed:25681350 - path(MESH:Smoking) increases path(MESH:"Alzheimer Disease") + p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") increases p(MGI:"chitinase-like 1") + + - pmid:21482353 + pubmed:25681350 - path(MESH:Smoking) decreases path(MESH:"Parkinson Disease") + p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") increases act(p(MGI:"interleukin 1 alpha")) - pmid:22807490 + pubmed:25681350 - path(MESH:Smoking) association path(MESH:"Hashimoto Disease") + p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") increases act(p(MGI:"oncostatin M")) + + - pmid:22807490 + pubmed:25681350 - path(MESH:Smoking) association path(MESH:"Colitis, Ulcerative") + p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105") increases r(MGI:"chitinase-like 1") - pmid:22807490 + pubmed:25681350 - path(MESH:Smoking) negativeCorrelation p(HGNC:TPO) + p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105") regulates p(MGI:"chitinase-like 1") + + - pmid:28391535 + pubmed:25681350 - path(MESH:Smoking) increases a(MESH:"Blood Glucose") + p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105") increases act(p(MGI:"interleukin 1 alpha")) - pmid:29196815 + pubmed:25681350 - path(MESH:Obesity) increases path(MESH:"Alzheimer Disease") + p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105") increases act(p(MGI:"oncostatin M")) + + + + - pmid:29196815 + pubmed:25681350 - path(MESH:"Diabetes Mellitus") increases path(MESH:"Alzheimer Disease") + p(MGI:"reticuloendotheliosis oncogene") causesNoChange p(MGI:"chitinase-like 1") - pmid:26195256 + pubmed:25681350 - path(MESH:"Diabetes Mellitus") increases path(MESH:"Alzheimer Disease") + p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100") causesNoChange p(MGI:"chitinase-like 1") - pmid:29626319 + pubmed:25681350 - path(MESH:"Diabetes Mellitus") negativeCorrelation p(HGNC:IDE) + p(HGNC:IL1A) increases p(HGNC:RELB) - pmid:29626319 + pubmed:25681350 - path(MESH:"Diabetes Mellitus") positiveCorrelation a(CHEBI:"amyloid-beta") + p(HGNC:IL1A) causesNoChange r(HGNC:CHI3L1) - pmid:29196815 + pubmed:25681350 - g(HBP:HBP00030) increases path(MESH:"Alzheimer Disease") + p(HGNC:IL1A) causesNoChange r(HGNC:RELB) - pmid:26837465 + pubmed:28745240 - complex(GO:"neurofibrillary tangle") association p(HGNC:ESR1) + act(p(HGNC:IL1A)) increases bp(GO:"p38MAPK cascade") - pmid:26837465 + pubmed:27794524 - complex(GO:"neurofibrillary tangle") association p(HGNC:ESR1) + p(HGNC:IL1A) directlyDecreases a(MESH:Oligodendroglia) - pmid:24368848 + pubmed:30967783 - complex(GO:"neurofibrillary tangle") causesNoChange act(a(MESH:Neurons)) + p(HGNC:IL1A) increases path(MESH:Inflammation) - pmid:23407988 + pubmed:23702978 - complex(GO:"neurofibrillary tangle") decreases complex(GO:"dendritic tree") + p(HGNC:IL1A) increases act(p(HGNC:IL1R1)) - pmid:10391244 + pubmed:23702978 - complex(GO:"neurofibrillary tangle") association complex(p(HGNC:MAPT, pmod(Ph, Thr, 231)), p(HGNC:PIN1, frag("5_39"))) + p(HGNC:IL1A) increases bp(GO:"inflammatory response") - pmid:10391244 + pubmed:25681350 - complex(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:CDK1) + p(HGNC:RELB) causesNoChange p(HGNC:CHI3L1) - pmid:12714745 + pubmed:25681350 - complex(GO:"neurofibrillary tangle") positiveCorrelation g(DBSNP:rs104893877) + p(MGI:"tumor necrosis factor") increases act(complex(GO:"NF-kappaB complex")) - pmid:29196815 + pubmed:25681350 - a(HBP:HBP00074) increases bp(GO:"neuron death") + p(MGI:"tumor necrosis factor") regulates r(MGI:"chitinase-like 1") - pmid:29196815 + pubmed:25681350 - a(HBP:HBP00074) increases bp(GO:"neuron death") + p(MGI:"tumor necrosis factor") increases act(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B")) - pmid:29196815 + pubmed:25681350 - a(HBP:HBP00074) positiveCorrelation bp(GO:"neuron death") + p(MGI:"tumor necrosis factor") increases act(complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105"))) - pmid:21718217 + pubmed:25681350 - a(HBP:HBP00074) increases bp(GO:"neuron death") + complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) regulates r(MGI:"chitinase-like 1") - pmid:29196815 + pubmed:25681350 - a(HBP:HBP00074) decreases a(MESH:Synapses) + complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) increases r(MGI:"chitinase-like 1") - pmid:29196815 + pubmed:25681350 - a(HBP:HBP00074) decreases a(MESH:Synapses) + complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"chitinase-like 1"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) - pmid:29196815 + pubmed:25681350 - a(HBP:HBP00074) decreases a(MESH:Synapses) + complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"chitinase-like 1"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) - pmid:29196815 + pubmed:21718217 - a(HBP:HBP00074) decreases bp(GO:memory) + r(HGNC:CHI3L1) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:29196815 + pubmed:25681350 - a(HBP:HBP00074) decreases bp(GO:memory) + p(HGNC:OSM) causesNoChange r(HGNC:CHI3L1) - pmid:29196815 + pubmed:25681350 - a(HBP:HBP00074) decreases bp(GO:memory) + p(HGNC:OSM) causesNoChange r(HGNC:RELB) - pmid:29196815 + pubmed:25024322 - a(HBP:HBP00074) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:CHI3L1) positiveCorrelation p(HGNC:MAPT) - pmid:29196815 + pubmed:25865441 - a(HBP:HBP00074) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:CHI3L1) positiveCorrelation p(HGNC:MAPT) - pmid:29196815 + pubmed:25865441 - a(HBP:HBP00074) decreases bp(GO:"neuronal signal transduction") + p(HGNC:CHI3L1) positiveCorrelation p(HGNC:MAPT) - pmid:29196815 + pubmed:26836182 - a(HBP:HBP00074) increases path(MESH:Dementia) + p(HGNC:CHI3L1) positiveCorrelation p(HGNC:MAPT) - pmid:29196815 + pubmed:26836182 - a(HBP:HBP00074) decreases bp(GO:"long-term synaptic potentiation") + p(HGNC:CHI3L1) positiveCorrelation p(HGNC:MAPT) - pmid:29196815 + pubmed:25024322 - a(HBP:HBP00074) decreases bp(GO:"long-term synaptic potentiation") + p(HGNC:CHI3L1) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:29196815 + pubmed:25865441 - a(HBP:HBP00074) decreases bp(GO:"signal release from synapse") + p(HGNC:CHI3L1) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:29196815 + pubmed:25865441 - a(HBP:HBP00074) increases bp(GO:"long term synaptic depression") + p(HGNC:CHI3L1) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:29196815 + pubmed:25024322 - a(HBP:HBP00074) increases p(HGNC:APP, pmod(Ph)) + p(HGNC:CHI3L1) positiveCorrelation a(CONSO:"CDR - Sum of Boxes") - pmid:29196815 + pubmed:25024322 - a(HBP:HBP00074) increases path(MESH:"Neuroaxonal Dystrophies") + p(HGNC:CHI3L1) positiveCorrelation a(NIFT:"Free and Cued Selective Reminding Test") - pmid:29196815 + pubmed:25024322 - a(HBP:HBP00074) increases bp(GO:"microglial cell activation") + p(HGNC:CHI3L1) positiveCorrelation a(CONSO:"Mini-Mental Status Exam") - pmid:29196815 + pubmed:25865441 - a(HBP:HBP00074) increases bp(GO:"astrocyte activation") + p(HGNC:CHI3L1) biomarkerFor path(MESH:Inflammation) - pmid:29196815 + pubmed:26979166 - a(HBP:HBP00074) positiveCorrelation bp(GO:"astrocyte activation") + p(HGNC:CHI3L1) association path(MESH:Inflammation) - pmid:29196815 + pubmed:25865441 - a(HBP:HBP00074) positiveCorrelation a(CHEBI:"amyloid fibril") + p(HGNC:CHI3L1) negativeCorrelation a(NIFT:"Cortical Thickness") - pmid:29196815 + pubmed:25865441 - a(HBP:HBP00074) increases act(p(HGNC:GRIN1)) + p(HGNC:CHI3L1) negativeCorrelation a(NIFT:"Cortical Thickness") - pmid:29196815 + pubmed:26836182 - a(HBP:HBP00074) regulates tloc(p(HGNC:GRIA1), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(HGNC:CHI3L1) negativeCorrelation a(NIFT:"Cortical Thickness") - pmid:29196815 + pubmed:25865441 - a(HBP:HBP00074) regulates tloc(p(HGNC:GRIA2), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(HGNC:CHI3L1) increases bp(GO:"inflammatory response") - pmid:29196815 + pubmed:26836182 - a(HBP:HBP00074) increases act(p(HGNC:NGFR)) + p(HGNC:CHI3L1) positiveCorrelation p(HGNC:NEFL) - pmid:29196815 + pubmed:26836182 - a(HBP:HBP00074) decreases p(HGNC:INSR) + p(HGNC:CHI3L1) increases p(HGNC:NEFL) - pmid:29196815 + pubmed:26836182 - a(HBP:HBP00074) negativeCorrelation a(HBP:HBP00352) + p(HGNC:CHI3L1) positiveCorrelation path(CONSO:neuroinflammation) - pmid:29196815 + pubmed:25681350 - a(HBP:HBP00074) positiveCorrelation path(MESH:"Cognitive Dysfunction") + p(HGNC:RELA) causesNoChange p(HGNC:CHI3L1) - pmid:29196815 + pubmed:21329555 - a(HBP:HBP00074) positiveCorrelation path(MESH:"Cognitive Dysfunction") + p(HGNC:RELA) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:21718217 + pubmed:25652642 - a(HBP:HBP00074) decreases bp(GO:"synaptic signaling") + p(HGNC:RELA, loc(GO:nucleus)) positiveCorrelation path(MESH:"Alzheimer Disease") + + - pmid:19293145 + pubmed:21329555 - a(MESH:Synapses) increases bp(GO:cognition) + p(HGNC:RELA) increases r(HGNC:BACE1) - pmid:29196815 + pubmed:21329555 - a(CHEBI:"amyloid fibril") causesNoChange bp(GO:memory) + p(HGNC:RELA) increases p(HGNC:BACE1) - pmid:29196815 + pubmed:21329555 - a(CHEBI:"amyloid fibril") positiveCorrelation a(HBP:HBP00074) + p(HGNC:RELA) increases p(CONSO:C99) - pmid:24653673 + pubmed:21329555 - p(HGNC:APP, pmod(Ph)) negativeCorrelation act(p(HGNC:GSK3B)) + p(HGNC:RELA) causesNoChange p(HGNC:APP) - pmid:24653673 + pubmed:21329555 - p(HGNC:APP, pmod(Ph)) negativeCorrelation act(p(HGNC:CDK5)) + p(HGNC:RELA) increases a(CHEBI:amyloid-beta) + + + + - pmid:24653673 + pubmed:28745240 - p(HGNC:APP, pmod(Ph)) negativeCorrelation act(p(FPLX:ERK)) + p(HGNC:RELA) increases bp(MESH:"Synaptic Transmission") - pmid:24653673 + pubmed:28745240 - p(HGNC:APP, pmod(Ph)) positiveCorrelation a(CHEBI:homocysteine) + p(HGNC:RELA) increases bp(GO:"long-term synaptic potentiation") - pmid:24653673 + pubmed:28745240 - p(HGNC:APP, pmod(Ph)) negativeCorrelation p(FPLX:PPP2, pmod(Me)) + p(HGNC:RELA) negativeCorrelation bp(GO:"apoptotic process") - pmid:29196815 + pubmed:27288790 - bp(GO:"astrocyte activation") positiveCorrelation a(HBP:HBP00074) + act(p(HGNC:RELA)) increases bp(GO:"apoptotic process") + + + + + + + + + + + + - pmid:27671637 + pubmed:27288790 - bp(GO:"astrocyte activation") negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) + p(HGNC:RELA) decreases bp(GO:"neuron apoptotic process") + + + + + + + + - pmid:27314526 + pubmed:26551702 - bp(GO:"astrocyte activation") increases sec(p(HGNC:IL1B)) + p(HGNC:RELA) increases p(HGNC:KEAP1, loc(MESH:"Cell Nucleus")) - pmid:27314526 + pubmed:26551702 - bp(GO:"astrocyte activation") increases sec(p(HGNC:IL6)) + act(p(HGNC:RELA)) decreases act(p(HGNC:NFE2L2)) - pmid:27314526 + pubmed:26551702 - bp(GO:"astrocyte activation") increases sec(p(HGNC:IL18)) + act(p(HGNC:RELA)) decreases act(complex(p(HGNC:CREBBP), p(HGNC:EP300))) - pmid:27314526 + pubmed:26551702 - bp(GO:"astrocyte activation") increases sec(p(HGNC:NOS2)) + p(HGNC:RELA) decreases complex(p(HGNC:CREBBP), p(HGNC:NFE2L2)) - pmid:29196815 + pubmed:26551702 - act(p(HGNC:GRIN1)) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(GO:"extracellular region"), toLoc(GO:"intracellular part")) + p(HGNC:RELA) increases act(p(FPLX:NFkappaB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) + + + + + + + + + + - pmid:29196815 + pubmed:25681350 - act(p(HGNC:GRIN1)) increases path(HBP:HBP00068) + path(MESH:Glioblastoma) increases p(MGI:"chitinase-like 1") - pmid:29196815 + pubmed:25681350 - act(p(HGNC:GRIN1)) increases path(HBP:HBP00037) + path(MESH:Glioblastoma) increases p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") - pmid:29196815 + pubmed:25681350 - act(p(HGNC:GRIN1)) decreases a(MESH:Synapses) + complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"chitinase-like 1"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) increases r(MGI:"chitinase-like 1") - pmid:24760868 + pubmed:25681350 - p(HGNC:GRIA1) positiveCorrelation bp(GO:"long-term synaptic potentiation") + composite(p(MGI:"interleukin 1 alpha"), p(MGI:"oncostatin M")) increases complex(p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B"), p(MGI:"chitinase-like 1"), p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")) + + - pmid:24760868 + pubmed:21329555 - p(HGNC:GRIA1) positiveCorrelation bp(GO:"long-term synaptic potentiation") + complex(g(HGNC:BACE1), p(FPLX:NFkappaB)) regulates r(HGNC:BACE1) + + + + + + - pmid:29196815 + pubmed:21329555 - a(HBP:HBP00075) decreases p(MGI:Adrb2) + act(p(FPLX:NFkappaB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases r(HGNC:BACE1) - pmid:29196815 + pubmed:29179999 - a(HBP:HBP00075) increases bp(GO:"microglial cell activation") + act(p(FPLX:NFkappaB)) association r(HGNC:BACE1) - pmid:29196815 + pubmed:29179999 - a(HBP:HBP00075) decreases bp(GO:"long-term synaptic potentiation") + act(p(FPLX:NFkappaB)) association bp(GO:"inflammatory response") - + + + pubmed:29179999 + + tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) increases bp(GO:"inflammatory response") + - pmid:29196815 + pubmed:27288790 - complex(a(HBP:HBP00074), p(HGNC:PRNP)) decreases bp(GO:"regulation of synaptic plasticity") + p(FPLX:NFkappaB) regulates bp(GO:"inflammatory response") - pmid:29196815 + pubmed:26551702 - p(HGNC:PRNP) decreases a(CHEBI:"amyloid fibril") + act(p(FPLX:NFkappaB)) increases bp(GO:"inflammatory response") + + + pubmed:29179999 + + p(FPLX:NFkappaB) positiveCorrelation path(MESH:"Alzheimer Disease") + + - pmid:21722302 + pubmed:27288790 - p(HGNC:PRNP) association bp(GO:"neuron development") + act(p(FPLX:NFkappaB)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:21722302 + pubmed:29179999 - p(HGNC:PRNP) association bp(GO:"neuron death") + act(p(FPLX:NFkappaB)) association path(HP:Neurodegeneration) - pmid:21722302 + pubmed:29179999 - p(HGNC:PRNP) decreases bp(MESH:"Oxidative Stress") + act(p(FPLX:NFkappaB)) regulates p(FPLX:"NADPH_oxidase") - pmid:21722302 + pubmed:26551702 - p(HGNC:PRNP) decreases p(HGNC:TNF) + p(FPLX:NFkappaB) increases p(FPLX:"NADPH_oxidase") - pmid:21722302 + pubmed:29179999 - p(HGNC:PRNP) decreases p(HGNC:BAX) + act(p(FPLX:NFkappaB)) regulates p(HGNC:PTGS2) - pmid:14556719 + pubmed:27288790 - p(HGNC:PRNP) increases complex(a(CHEBI:"copper(2+)"), p(HGNC:PRNP)) + p(FPLX:NFkappaB) increases p(HGNC:PTGS2) + + + pubmed:29179999 + + act(p(FPLX:NFkappaB)) regulates a(MESH:Interleukins) + + - pmid:14556719 + pubmed:29179999 - tloc(p(HGNC:PRNP), fromLoc(MESH:"Endoplasmic Reticulum"), toLoc(GO:cytosol)) increases deg(p(HGNC:PRNP)) + act(p(FPLX:NFkappaB)) regulates p(FPLX:SOD) - pmid:28420982 + pubmed:29179999 - p(HGNC:PRNP) association a(HBP:"Tau oligomers") + act(p(FPLX:NFkappaB)) association r(HGNC:NLRP3) @@ -47456,738 +47935,765 @@

Statements

- pmid:29196815 + pubmed:27288790 - a(HBP:HBP00023) increases a(CHEBI:"calcium(2+)") + p(FPLX:NFkappaB) association path(MESH:Inflammation) - pmid:29196815 + pubmed:26551702 - a(HBP:HBP00023) increases complex(p(HGNC:GRIK1), p(HGNC:PRNP)) + p(FPLX:NFkappaB) regulates path(MESH:Inflammation) - pmid:29196815 + pubmed:27288790 - a(HBP:HBP00023) decreases bp(GO:"signal release from synapse") + p(FPLX:NFkappaB) association bp(GO:"negative regulation of neuron apoptotic process") - - - - - pmid:29196815 + pubmed:27288790 - p(HGNC:NGFR) positiveCorrelation path(MESH:"Alzheimer Disease") + p(FPLX:NFkappaB) association bp(GO:"neuron differentiation") - pmid:29196815 + pubmed:27288790 - p(HGNC:NGFR) positiveCorrelation path(MESH:"Cognitive Dysfunction") + p(FPLX:NFkappaB) association bp(GO:"apoptotic process") - pmid:18986241 + pubmed:27288790 - p(HGNC:NGFR) association bp(GO:"GO:1901214") + p(FPLX:NFkappaB) association bp(MESH:"Neuronal Outgrowth") - pmid:18986241 + pubmed:27288790 - p(HGNC:NGFR) increases act(p(HGNC:BACE1)) + p(FPLX:NFkappaB) association bp(GO:"regulation of synaptic plasticity") + + + + - pmid:18986241 + pubmed:27288790 - p(HGNC:NGFR) increases a(CHEBI:"amyloid-beta") + act(p(FPLX:NFkappaB)) increases r(HGNC:IL1B) - pmid:18986241 + pubmed:27288790 - act(p(HGNC:NGFR)) association bp(GO:"GO:0006665") + act(p(FPLX:NFkappaB)) increases r(HGNC:TNF) - pmid:18986241 + pubmed:27288790 - act(p(HGNC:NGFR)) increases bp(GO:"GO:0007254") + act(p(FPLX:NFkappaB)) decreases p(HGNC:UCHL1) - pmid:18986241 + pubmed:27288790 - act(p(HGNC:NGFR)) increases bp(GO:"GO:0038061") + p(FPLX:NFkappaB) regulates act(p(HGNC:NOS2)) - pmid:18986241 + pubmed:27288790 - act(p(HGNC:NGFR)) increases bp(GO:"GO:0043491") + act(p(FPLX:NFkappaB)) increases a(MESH:Cytokines) - pmid:18986241 + pubmed:26551702 - act(p(HGNC:NGFR)) increases bp(GO:"GO:0000165") + act(p(FPLX:NFkappaB)) increases a(MESH:Cytokines) - pmid:22142809 + pubmed:27288790 - p(HGNC:NGFR) association p(HBP:RAC1b) + act(p(FPLX:NFkappaB)) increases a(MESH:Chemokines) - pmid:29196815 + pubmed:27288790 - a(HBP:HBP00352) negativeCorrelation a(HBP:HBP00074) + p(FPLX:NFkappaB) increases m(MIRBASE:hsa-mir-125b-1) - pmid:29196815 + pubmed:27288790 - path(MESH:"Cognitive Dysfunction") positiveCorrelation a(HBP:HBP00074) + p(FPLX:NFkappaB) increases m(MIRBASE:hsa-mir-125b-2) - pmid:29196815 + pubmed:27288790 - path(MESH:"Cognitive Dysfunction") positiveCorrelation a(HBP:HBP00074) + p(FPLX:NFkappaB) increases m(MIRBASE:hsa-mir-146a) - pmid:29196815 + pubmed:27288790 - path(MESH:"Cognitive Dysfunction") positiveCorrelation p(HGNC:NGFR) + p(FPLX:NFkappaB) increases m(MIRBASE:hsa-mir-155) - pmid:19293145 + pubmed:27288790 - path(MESH:"Cognitive Dysfunction") positiveCorrelation a(HBP:"amyloid-beta oligomers") + act(p(FPLX:NFkappaB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases m(MIRBASE:hsa-mir-155) - pmid:19293145 + pubmed:26551702 - path(MESH:"Cognitive Dysfunction") association path(MESH:"Alzheimer Disease") + p(FPLX:NFkappaB) regulates bp(GO:"immune response") - pmid:24511233 + pubmed:26551702 - path(MESH:"Cognitive Dysfunction") association path(MESH:"Alzheimer Disease") + p(FPLX:NFkappaB) regulates bp(GO:"developmental process") - pmid:24511233 + pubmed:26551702 - path(MESH:"Cognitive Dysfunction") association path(MESH:"Alzheimer Disease") + p(FPLX:NFkappaB) regulates bp(GO:"cell population proliferation") - pmid:26813123 + pubmed:26551702 - path(MESH:"Cognitive Dysfunction") positiveCorrelation path(MESH:"Alzheimer Disease") + p(FPLX:NFkappaB) regulates bp(GO:"UV protection") - pmid:24511233 + pubmed:26551702 - path(MESH:"Cognitive Dysfunction") association path(MESH:Schizophrenia) + p(FPLX:NFkappaB) increases act(a(MESH:Mitochondria)) - pmid:26813123 + pubmed:26551702 - path(MESH:"Cognitive Dysfunction") negativeCorrelation a(GO:synapse) + act(p(FPLX:NFkappaB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) regulates bp(MESH:"Antioxidant Response Elements") - pmid:26813123 + pubmed:26551702 - path(MESH:"Cognitive Dysfunction") association act(p(HGNC:CHRM1)) + act(p(FPLX:NFkappaB)) increases p(HGNC:NFE2L2) - pmid:27522251 + pubmed:30640040 - path(MESH:"Cognitive Dysfunction") increases path(MESH:"Plaque, Amyloid") + p(FPLX:NFkappaB) association a(PUBCHEM:5318517) + + - pmid:21482353 + pubmed:26118667 - path(MESH:"Cognitive Dysfunction") association p(HGNC:LYNX1) + p(FPLX:NFkappaB) increases complex(g(MIRBASE:rno-mir-195), p(FPLX:NFkappaB)) + + - pmid:11230871 + pubmed:21329555 - path(MESH:"Cognitive Dysfunction") negativeCorrelation p(FPLX:CHRN) + complex(g(HGNC:BACE1), p(HGNC:RELA)) increases r(HGNC:BACE1) - pmid:29687724 + pubmed:21329555 - path(MESH:"Cognitive Dysfunction") association path(MESH:"Huntington Disease") + r(HGNC:NFKBIA) decreases a(CHEBI:amyloid-beta) - pmid:29687724 + pubmed:21329555 - path(MESH:"Cognitive Dysfunction") isA path(MESH:"Neurocognitive Disorders") + bp(GO:"NIK/NF-kappaB signaling") association path(MESH:Inflammation) - pmid:29687724 + pubmed:21329555 - path(MESH:"Cognitive Dysfunction") decreases path(MESH:Thinking) + bp(GO:"NIK/NF-kappaB signaling") association path(MESH:"Oxidative Stress") - pmid:29687724 + pubmed:21329555 - path(MESH:"Cognitive Dysfunction") decreases path(MESH:"Executive Function") + path(MESH:"Oxidative Stress") association bp(GO:"NIK/NF-kappaB signaling") - pmid:29687724 + pubmed:30962309 - path(MESH:"Cognitive Dysfunction") decreases path(MESH:Memory) + path(MESH:"Oxidative Stress") increases a(CHEBI:"reactive oxygen species") - pmid:24027553 + pubmed:27794524 - path(MESH:"Cognitive Dysfunction") positiveCorrelation path(MESH:Tauopathies) + path(MESH:"Oxidative Stress") association bp(GO:"neuron death") - pmid:30108137 + pubmed:27794524 - path(MESH:"Cognitive Dysfunction") positiveCorrelation r(HGNC:TFEB) + path(MESH:"Oxidative Stress") negativeCorrelation bp(GO:"myelin maintenance") - pmid:30126037 + pubmed:27956442 - path(MESH:"Cognitive Dysfunction") association p(HGNC:CDKN2A) + path(MESH:"Oxidative Stress") directlyIncreases path(MESH:Inflammation) - pmid:30126037 + pubmed:27956442 - path(MESH:"Cognitive Dysfunction") association bp(MESH:"Cerebrovascular Circulation") + path(MESH:"Oxidative Stress") increases path(MESH:"Amnesia, Anterograde") - pmid:19765634 + pubmed:27956442 - path(MESH:"Cognitive Dysfunction") positiveCorrelation g(DBSNP:rs8052688) + path(MESH:"Oxidative Stress") increases path(MESH:"Amnesia, Retrograde") - pmid:19765634 + pubmed:23516100 - path(MESH:"Cognitive Dysfunction") positiveCorrelation g(DBSNP:rs8063) + path(MESH:"Oxidative Stress") association p(MESH:Proteins, frag("?")) - pmid:29196815 + pubmed:30688256 - a(HBP:HBP00076) positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:"Oxidative Stress") increases bp(GO:mitophagy) - pmid:29196815 + pubmed:30688256 - a(HBP:HBP00076) biomarkerFor path(MESH:"Alzheimer Disease") + path(MESH:"Oxidative Stress") increases path(MESH:"Parkinson Disease") - pmid:18650430 + pubmed:30012004 - p(HGNC:APP, var("?")) increases path(MESH:"Alzheimer Disease") + path(MESH:"Oxidative Stress") positiveCorrelation path(MESH:"Huntington Disease") - pmid:14556719 + pubmed:26968346 - p(HGNC:APP, var("?")) increases path(MESH:"Alzheimer Disease") + path(MESH:"Oxidative Stress") decreases p(HGNCGENEFAMILY:"MTOR complex 1") - pmid:22908190 + pubmed:26968346 - p(HGNC:APP, var("?")) positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:"Oxidative Stress") increases tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) - pmid:22908190 + pubmed:30837838 - p(HGNC:APP, var("?")) positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:"Oxidative Stress") increases p(HGNC:TARDBP, pmod(go:0006473 ! "protein acetylation")) - pmid:18650430 + pubmed:30837838 - p(HGNC:APP, var("?")) increases path(MESH:"Cerebral Amyloid Angiopathy, Familial") + path(MESH:"Oxidative Stress") increases p(CONSO:"TDP-43 aggregates") - pmid:14556719 + pubmed:30837838 - p(HGNC:APP, var("?")) increases a(HBP:"amyloid-beta aggregates") + path(MESH:"Oxidative Stress") association path(MESH:"Amyotrophic Lateral Sclerosis") - pmid:22908190 + pubmed:30837838 - p(HGNC:APP, var("?")) increases bp(GO:endocytosis) + path(MESH:"Oxidative Stress") increases bp(GO:"peptidyl-cysteine oxidation") - pmid:22908190 + pubmed:21329555 - p(HGNC:APP, var("?")) negativeCorrelation act(a(MESH:Neurites)) + p(HGNC:TNF) increases bp(GO:"NIK/NF-kappaB signaling") - pmid:28420982 + pubmed:21329555 - path(MESH:"Cerebral Amyloid Angiopathy, Familial") association a(MESH:"Heparan Sulfate Proteoglycans") + p(HGNC:TNF) increases r(HGNC:BACE1) - pmid:18650430 + pubmed:21329555 - act(p(HGNC:ADAM17), ma(pep)) increases rxn(reactants(p(HGNC:APP)), products(p(HGNC:APP, frag("17_*")), p(HGNC:APP, frag("1_16")))) + p(HGNC:TNF) increases r(HGNC:BACE1) - pmid:21214928 + pubmed:21958873 - p(HGNC:ADAM17) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067))) + p(HGNC:TNF) increases r(HGNC:BACE1) - pmid:22122372 + pubmed:25331948 - p(HGNC:ADAM17) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067))) + p(HGNC:TNF) increases r(HGNC:BACE1) - pmid:22122372 + pubmed:21329555 - p(HGNC:ADAM17) increases a(HBP:HBP00067) + p(HGNC:TNF) increases act(p(FPLX:NFkappaB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) - - - + + + pubmed:29179999 + + p(HGNC:TNF) increases act(p(FPLX:NFkappaB)) + - pmid:18650430 + pubmed:27288790 - act(p(HGNC:ADAM9), ma(pep)) increases rxn(reactants(p(HGNC:APP)), products(p(HGNC:APP, frag("17_*")), p(HGNC:APP, frag("1_16")))) + p(HGNC:TNF) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) - pmid:22122372 + pubmed:27288790 - p(HGNC:ADAM9) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067))) + p(HGNC:TNF) increases act(p(FPLX:NFkappaB)) - pmid:22122372 + pubmed:26551702 - p(HGNC:ADAM9) increases a(HBP:HBP00067) + p(HGNC:TNF) increases act(p(FPLX:NFkappaB)) - pmid:18650430 + pubmed:28745240 - act(p(HGNC:ADAM10), ma(pep)) increases rxn(reactants(p(HGNC:APP)), products(p(HGNC:APP, frag("17_*")), p(HGNC:APP, frag("1_16")))) + p(HGNC:TNF) increases act(complex(GO:"NF-kappaB complex")) - pmid:21214928 + pubmed:21958873 - p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(p(HGNC:APP, frag("17_*")), p(HGNC:APP, frag("1_16")))) + p(HGNC:TNF) increases act(complex(GO:"NF-kappaB complex")) - pmid:21214928 + pubmed:25331948 - p(HGNC:ADAM10) increases p(HBP:HBP00067) + p(HGNC:TNF) increases act(complex(GO:"NF-kappaB complex")) - pmid:21214928 + pubmed:28745240 - p(HGNC:ADAM10) decreases a(CHEBI:"amyloid-beta") + p(HGNC:TNF) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:21214928 + pubmed:27288790 - p(HGNC:ADAM10) decreases a(CHEBI:"amyloid-beta") + p(HGNC:TNF) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:22122372 + pubmed:25652642 - p(HGNC:ADAM10) decreases a(CHEBI:"amyloid-beta") + p(HGNC:TNF) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:21214928 + pubmed:28745240 - p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067))) + p(HGNC:TNF) increases path(CONSO:neurotoxicity) - pmid:21214928 + pubmed:28745240 - p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067))) + p(HGNC:TNF) increases bp(GO:"neuron death") - pmid:22122372 + pubmed:27288790 - p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067))) + p(HGNC:TNF) increases p(FPLX:"IKK_complex", pmod(go:0006468 ! "protein phosphorylation")) - pmid:22122372 + pubmed:27288790 - p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067))) + p(HGNC:TNF) increases p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation")) - pmid:21214928 + pubmed:23178521 - p(HGNC:ADAM10) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:TNF) increases p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation")) - pmid:21214928 + pubmed:23178521 - act(p(HGNC:ADAM10)) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:TNF) increases p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation")) - pmid:22122372 + pubmed:23178521 - p(HGNC:ADAM10) increases sec(p(HGNC:APP)) + p(HGNC:TNF) increases p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation")) - pmid:24590577 + pubmed:27288790 - p(HGNC:ADAM10) increases deg(p(HGNC:APP)) + p(HGNC:TNF) decreases p(FPLX:IKB) - pmid:22122372 + pubmed:27288790 - p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00067), a(HBP:HBP00072))) + p(HGNC:TNF) increases a(MESH:Cytokines) - pmid:22122372 + pubmed:27794524 - p(HGNC:ADAM10) increases a(HBP:HBP00067) + p(HGNC:TNF) isA a(MESH:Cytokines) - pmid:22122372 + pubmed:27288790 - p(HGNC:ADAM10) decreases path(MESH:"Plaque, Amyloid") + p(HGNC:TNF) increases a(MESH:Chemokines) - pmid:24590577 + pubmed:27288790 - p(HGNC:ADAM10) increases a(HBP:"sAPP-alpha") + p(HGNC:TNF) increases act(p(HGNC:BACE1)) - pmid:18650430 + pubmed:25331948 - act(p(HGNC:BACE2), ma(pep)) increases rxn(reactants(p(HGNC:APP)), products(p(HGNC:APP, frag("17_*")), p(HGNC:APP, frag("1_16")))) + p(HGNC:TNF) increases p(HGNC:BACE1) - pmid:21214928 + pubmed:27288790 - p(HGNC:BACE2) association rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) + p(HGNC:TNF) increases act(p(FPLX:ERK)) - pmid:21214928 + pubmed:27288790 - p(HGNC:BACE2) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) + p(HGNC:TNF) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - + + + pubmed:25652642 + + p(HGNC:TNF) increases p(HGNC:NGF) + - + + + pubmed:25652642 + + p(HGNC:TNF) increases p(HGNC:BCL2) + - + + + pubmed:26551702 + + p(HGNC:TNF) increases act(p(HGNC:NFE2L2), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) + - + + + pubmed:30962309 + + p(HGNC:TNF) increases bp(GO:"cell death") + @@ -48195,2039 +48701,1999 @@

Statements

- pmid:18650430 + pubmed:27794524 - complex(FPLX:"Gamma_secretase") increases a(MESH:"Amyloid beta-Peptides") + p(HGNC:TNF) positiveCorrelation path(MESH:"Complement Activation") - pmid:18650430 + pubmed:27794524 - complex(FPLX:"Gamma_secretase") increases a(HBP:HBP00071) + p(HGNC:TNF) positiveCorrelation act(p(MESH:T-Lymphocytes)) - pmid:22122372 + pubmed:27794524 - complex(FPLX:"Gamma_secretase") increases a(HBP:HBP00071) + p(HGNC:TNF) directlyDecreases a(MESH:Oligodendroglia) - pmid:21214928 + pubmed:26445701 - complex(FPLX:"Gamma_secretase") increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) + p(HGNC:TNF) regulates path(MESH:Inflammation) - pmid:22122372 + pubmed:30967783 - complex(FPLX:"Gamma_secretase") increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) + p(HGNC:TNF) increases path(MESH:Inflammation) - pmid:21722302 + pubmed:26979166 - complex(FPLX:"Gamma_secretase") increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) + tloc(p(HGNC:TNF), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) increases path(MESH:Inflammation) - pmid:21214928 + pubmed:26979166 - complex(FPLX:"Gamma_secretase") increases rxn(reactants(a(HBP:HBP00024)), products(a(CHEBI:"amyloid-beta"), a(HBP:HBP00072))) + p(HGNC:TNF) increases path(MESH:Inflammation) - pmid:21214928 + pubmed:26445701 - complex(FPLX:"Gamma_secretase") increases p(HBP:HBP00024, frag("?")) + p(HGNC:TNF) increases path(HP:"CNS demyelination") - pmid:21214928 + pubmed:26445701 - complex(FPLX:"Gamma_secretase") increases p(HGNC:NOTCH1, frag("?")) + p(HGNC:TNF) increases path(MESH:"Diffuse Axonal Injury") - pmid:21214928 + pubmed:26445701 - complex(FPLX:"Gamma_secretase") increases p(FPLX:Cadherin, frag("?")) + p(HGNC:TNF) increases bp(GO:"positive regulation of oligodendrocyte apoptotic process") - pmid:21214928 + pubmed:30967783 - complex(FPLX:"Gamma_secretase") increases p(HGNC:TYR, frag("?")) + p(HGNC:TNF) increases a(CHEBI:"2 L-glutamate") - pmid:21214928 + pubmed:30967783 - complex(FPLX:"Gamma_secretase") increases p(HGNC:ERBB4, frag("?")) + p(HGNC:TNF) negativeCorrelation act(a(MESH:Astrocytes)) - pmid:21214928 + pubmed:30967783 - complex(FPLX:"Gamma_secretase") increases p(HGNC:CD44, frag("?")) + p(HGNC:TNF) increases bp(MESH:Neuroprotection) - pmid:22122372 + pubmed:19126755 - complex(FPLX:"Gamma_secretase") increases rxn(reactants(a(HBP:HBP00072)), products(a(HBP:HBP00071), a(HBP:HBP00080))) + p(HGNC:TNF) increases bp(GO:"MAPK cascade") - pmid:22122372 + pubmed:19293145 - complex(FPLX:"Gamma_secretase") increases rxn(reactants(a(HBP:HBP00081)), products(a(HBP:HBP00071), a(MESH:"Amyloid beta-Peptides"))) + p(HGNC:TNF) increases act(a(CHEBI:nicotine)) - pmid:22122372 + pubmed:19293145 - complex(FPLX:"Gamma_secretase") increases p(HGNC:APP, frag("1_38")) + p(HGNC:TNF) decreases act(a(CHEBI:"N-methyl-D-aspartic acid")) - pmid:22122372 + pubmed:23178521 - complex(FPLX:"Gamma_secretase") increases p(HGNC:APP, frag("1_43")) + p(HGNC:TNF) causesNoChange p(HGNC:STAT3, pmod(go:0006468 ! "protein phosphorylation")) - pmid:22122372 + pubmed:23178521 - complex(FPLX:"Gamma_secretase") increases p(HGNC:APP, frag("672_711")) + p(HGNC:TNF) increases p(HGNC:STAT3, pmod(go:0006468 ! "protein phosphorylation")) - pmid:21722302 + pubmed:23178521 - complex(FPLX:"Gamma_secretase") increases p(HGNC:APP, frag("672_711")) + p(HGNC:TNF) increases p(HGNC:STAT3, pmod(go:0006468 ! "protein phosphorylation")) - pmid:24590577 + pubmed:25331948 - complex(FPLX:"Gamma_secretase") increases deg(a(HBP:C99)) + p(HGNC:TNF) increases a(MESH:"Amyloid beta-Peptides") + + - pmid:24590577 + pubmed:30988501 - complex(FPLX:"Gamma_secretase") increases a(CHEBI:"amyloid-beta") + p(HGNC:TNF) increases bp(GO:"regulation of action potential firing rate") - pmid:29626319 + pubmed:30988501 - complex(FPLX:"Gamma_secretase") increases a(CHEBI:"amyloid-beta") + p(HGNC:TNF) increases a(MESH:"Neural Pathways") - pmid:24590577 + pubmed:30988501 - complex(FPLX:"Gamma_secretase") increases a(HBP:AICD) + p(HGNC:TNF) increases act(a(MESH:Microglia)) - pmid:21722302 + pubmed:30988501 - complex(FPLX:"Gamma_secretase") increases p(HGNC:APP, frag("672_713")) + p(HGNC:TNF) increases a(MESH:"Synaptic Membranes") - - - pmid:21722302 + pubmed:21329555 - complex(FPLX:"Gamma_secretase") negativeCorrelation p(HGNC:UBQLN1) + a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") decreases r(HGNC:BACE1) - - - pmid:21718217 + pubmed:27288790 - p(HGNC:APH1A) decreases p(HGNC:APP) + a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") decreases act(p(HGNC:BACE1)) - pmid:21718217 + pubmed:19126755 - p(HGNC:APH1A) increases a(CHEBI:"amyloid-beta polypeptide 42") + a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") decreases act(p(HGNC:PTGS1)) - pmid:18650430 + pubmed:19126755 - p(HGNC:APBA1) decreases a(CHEBI:"amyloid-beta") + a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") decreases act(p(HGNC:PTGS2)) - pmid:18650430 + pubmed:21329555 - p(HGNC:APBA1) decreases a(HBP:HBP00018) + a(CHEBI:ibuprofen) isA a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") - pmid:18650430 + pubmed:27288790 - p(HGNC:APBA1) regulates bp(HBP:HBP00073) + a(CHEBI:ibuprofen) isA a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") - pmid:21214928 + pubmed:21329555 - bp(HBP:HBP00073) association p(HGNC:RAB6A) + a(CHEBI:ibuprofen) decreases r(HGNC:BACE1) - pmid:22122372 + pubmed:27288790 - bp(HBP:HBP00073) association p(HBP:HBP00071, pmod(Ph, Thr, 654)) + a(CHEBI:ibuprofen) decreases r(HGNC:BACE1) - pmid:22122372 + pubmed:27288790 - bp(HBP:HBP00073) association p(HBP:HBP00071, pmod(Ph, Thr, 668)) + a(CHEBI:ibuprofen) decreases a(CHEBI:amyloid-beta) - pmid:22122372 + pubmed:21329555 - bp(HBP:HBP00073) association p(HBP:HBP00071, pmod(Ph, Ser, 665)) + a(PUBCHEM:3715) isA a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") - pmid:18650430 + pubmed:21329555 - p(HGNC:APBA2) decreases a(CHEBI:"amyloid-beta") + a(PUBCHEM:3715) decreases r(HGNC:BACE1) + + - pmid:18650430 + pubmed:28745240 - p(HGNC:APBA2) decreases a(HBP:HBP00018) + p(HGNC:SYP) increases complex(p(HGNC:NFKB1), p(HGNC:RELA), p(HGNC:SYP)) - pmid:18650430 + pubmed:26813123 - p(HGNC:APBA2) regulates bp(HBP:HBP00073) + p(HGNC:SYP) association bp(GO:memory) - - - pmid:18650430 - - p(HGNC:APBB1) decreases a(CHEBI:"amyloid-beta") - + - pmid:18650430 + pubmed:28745240 - p(HGNC:APBB1) decreases a(HBP:HBP00018) + p(HGNC:NFKB1) increases bp(GO:"long-term synaptic potentiation") - pmid:18650430 + pubmed:28745240 - p(HGNC:APBB1) regulates bp(HBP:HBP00073) + p(HGNC:NFKB1) increases path(MESH:"Spatial Memory") - pmid:18650430 + pubmed:28745240 - p(HGNC:APBB1) increases a(HBP:HBP00071) + p(HGNC:NFKB1) increases bp(GO:learning) - pmid:21214928 + pubmed:28745240 - act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:APP) + p(HGNC:NFKB1) increases path(MESH:Anxiety) + + - pmid:21214928 + pubmed:27288790 - act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:GSK3B) + act(p(HGNC:NFKB1)) increases bp(GO:"apoptotic process") - - - pmid:21214928 - - act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:CD82) - + + + - pmid:21214928 + pubmed:30988501 - act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:MME) + p(HGNC:NFKB1) increases a(MESH:Cytokines) - pmid:21214928 + pubmed:23702978 - act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:BACE1) + p(HGNC:NFKB1) increases p(HGNC:IL1B) - pmid:21214928 + pubmed:28745240 - act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:EGFR) + a(GO:synapse) association complex(p(HGNC:NFKB1), p(HGNC:RELA)) - pmid:21214928 + pubmed:30967783 - act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:LRP1) + a(GO:synapse) increases bp(GO:"learning or memory") - pmid:21214928 + pubmed:30967783 - a(HBP:HBP00071) increases bp(GO:"apoptotic process") + a(GO:synapse) increases bp(GO:"learning or memory") - pmid:18650430 + pubmed:30061532 - p(HGNC:SORL1) decreases a(CHEBI:"amyloid-beta") + act(a(GO:synapse)) association path(CONSO:Neurodegeneration) - pmid:21214928 + pubmed:30061532 - p(HGNC:SORL1) decreases a(CHEBI:"amyloid-beta") + a(GO:synapse) association p(HGNC:DISC1) - pmid:29758300 + pubmed:30515821 - p(HGNC:SORL1) negativeCorrelation a(CHEBI:"amyloid-beta") + act(a(GO:synapse)) positiveCorrelation path(MESH:"Mitochondrial Dynamics") - pmid:29758300 + pubmed:26813123 - p(HGNC:SORL1) association path(MESH:"Alzheimer Disease") + a(GO:synapse) negativeCorrelation path(MESH:"Cognitive Dysfunction") - pmid:21214928 + pubmed:25514383 - bp(GO:"synapse assembly") association p(HGNC:APP) + a(GO:synapse) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:30106381 + pubmed:22908190 - bp(GO:"synapse assembly") association p(HGNC:ADNP) + act(a(GO:synapse)) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:30106381 + pubmed:22908190 - bp(GO:"synapse assembly") association a(PUBCHEM:9832404) + act(a(GO:synapse)) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:27807169 + pubmed:28445721 - bp(GO:"synapse assembly") positiveCorrelation p(RGD:Cdk5r2) + act(a(GO:synapse)) regulates p(FPLX:CHRN) - - - - - pmid:18650430 + pubmed:30106381 - composite(p(HGNC:APP), p(HGNC:CNTN2)) decreases bp(GO:neurogenesis) + act(a(GO:synapse)) association p(HGNC:ADNP) - pmid:26813123 + pubmed:30106381 - p(HGNC:SLC5A7) increases tloc(a(CHEBI:choline), fromLoc(GO:"synaptic cleft"), toLoc(MESH:"Cholinergic Neurons")) + act(a(GO:synapse)) association a(PUBCHEM:9832404) - pmid:26813123 + pubmed:22908190 - p(HGNC:SLC5A7) increases tloc(a(CHEBI:choline), fromLoc(GO:"synaptic cleft"), toLoc(MESH:"Cholinergic Neurons")) + act(a(GO:synapse)) positiveCorrelation bp(GO:cognition) - pmid:26813123 + pubmed:22908190 - p(HGNC:SLC5A7) increases a(CHEBI:choline) + act(a(GO:synapse)) decreases path(MESH:"Plaque, Amyloid") - pmid:26813123 + pubmed:22908190 - p(HGNC:SLC5A7) increases tloc(a(CHEBI:choline), fromLoc(GO:"synaptic cleft"), toLoc(MESH:"Cholinergic Neurons")) + act(a(GO:synapse)) positiveCorrelation bp(GO:endocytosis) - pmid:26813123 + pubmed:22908190 - p(HGNC:SLC5A7) increases a(CHEBI:acetylcholine) + act(a(GO:synapse)) positiveCorrelation p(HGNC:CTSB) + + - pmid:17293005 + pubmed:26631930 - p(HGNC:BACE1, frag("67_78")) decreases sec(a(HBP:"sAPP-beta")) + act(a(GO:synapse)) increases tloc(p(HGNC:MAPT), fromLoc(GO:"dendritic shaft"), toLoc(GO:"excitatory synapse")) - pmid:17293005 + pubmed:26631930 - p(HGNC:BACE1, frag("67_78")) decreases a(HBP:"sAPP-beta") + act(a(GO:synapse)) negativeCorrelation p(HGNC:MAPT) - pmid:17293005 + pubmed:27796283 - p(HGNC:BACE1, frag("67_78")) decreases sec(a(HBP:"sAPP-alpha")) + act(a(GO:synapse)) negativeCorrelation act(p(HGNC:RHOA)) - pmid:17293005 + pubmed:27796283 - p(HGNC:BACE1, frag("67_78")) increases a(HBP:"sAPP-alpha", loc(GO:intracellular)) + a(GO:synapse) regulates p(HGNC:CAMKV) - pmid:17293005 + pubmed:22156579 - p(HGNC:BACE1, frag("67_78")) increases a(HBP:"sAPP-alpha") + a(GO:synapse) negativeCorrelation p(HGNC:MARK4) - pmid:17293005 + pubmed:28745240 - p(HGNC:BACE1, frag("67_78")) causesNoChange a(CHEBI:"amyloid-beta") + complex(p(HGNC:NFKB1), p(HGNC:RELA)) association a(GO:synapse) - pmid:17293005 + pubmed:28745240 - p(HGNC:BACE1, frag("67_78")) causesNoChange p(HGNC:ACTB) + complex(p(HGNC:NFKB1), p(HGNC:RELA)) increases complex(p(HGNC:BACE1), p(HGNC:NFKB1), p(HGNC:RELA)) - pmid:17293005 + pubmed:25652642 - p(HGNC:BACE1, frag("67_78")) causesNoChange act(p(HGNC:BACE1)) + act(complex(p(HGNC:NFKB1), p(HGNC:RELA))) increases bp(GO:"apoptotic process") - pmid:17293005 + pubmed:21214928 - p(HGNC:BACE1, frag("67_78")) decreases a(CHEBI:"amyloid-beta polypeptide 40") + bp(MESH:"Synaptic Transmission") association a(CHEBI:amyloid-beta) - pmid:17293005 + pubmed:26813123 - p(HGNC:BACE1, frag("69_75")) causesNoChange sec(a(HBP:"sAPP-beta")) + bp(MESH:"Synaptic Transmission") association bp(GO:memory) - pmid:17293005 + pubmed:14556719 - p(HGNC:BACE1, frag("69_75")) causesNoChange sec(a(HBP:"sAPP-alpha")) + bp(MESH:"Synaptic Transmission") association p(HGNC:PRKN) - pmid:17293005 + pubmed:28745240 - p(HGNC:BACE1, frag("69_75")) causesNoChange a(CHEBI:"amyloid-beta") + p(HGNC:REL) increases bp(GO:"long-term synaptic depression") - - - pmid:17293005 - - p(HGNC:BACE1, frag("69_75")) causesNoChange p(HGNC:ACTB) - + + + - pmid:17293005 + pubmed:28745240 - p(HGNC:BACE1, frag("228_236")) decreases sec(a(HBP:"sAPP-beta")) + bp(GO:"long-term synaptic depression") decreases p(HGNC:NFKB1) - pmid:17293005 + pubmed:28745240 - p(HGNC:BACE1, frag("228_236")) decreases a(HBP:"sAPP-beta") + bp(GO:"long-term synaptic depression") decreases p(HGNC:RELA) - pmid:17293005 + pubmed:27041503 - p(HGNC:BACE1, frag("228_236")) decreases sec(a(HBP:"sAPP-alpha")) + bp(GO:"long-term synaptic depression") decreases bp(GO:"regulation of synaptic plasticity") - pmid:17293005 + pubmed:21871088 - p(HGNC:BACE1, frag("228_236")) increases a(HBP:"sAPP-alpha", loc(GO:intracellular)) + bp(GO:"long-term synaptic depression") association bp(GO:"calcium ion import") - pmid:17293005 + pubmed:21871088 - p(HGNC:BACE1, frag("228_236")) increases a(HBP:"sAPP-alpha") + bp(GO:"long-term synaptic depression") association bp(GO:"cellular calcium ion homeostasis") - pmid:17293005 + pubmed:22908190 - p(HGNC:BACE1, frag("228_236")) causesNoChange a(CHEBI:"amyloid-beta") + bp(GO:"long-term synaptic depression") negativeCorrelation act(p(HGNC:RAB5A)) - pmid:17293005 + pubmed:26631930 - p(HGNC:BACE1, frag("228_236")) causesNoChange p(HGNC:ACTB) + bp(GO:"long-term synaptic depression") association p(HGNC:MAPT) - pmid:17293005 + pubmed:28745240 - p(HGNC:BACE1, frag("228_236")) causesNoChange act(p(HGNC:BACE1)) + path(MESH:"Spatial Memory") association bp(GO:"long-term synaptic potentiation") - pmid:17293005 + pubmed:28745240 - p(HGNC:BACE1, frag("228_236")) decreases a(CHEBI:"amyloid-beta polypeptide 40") + a(CHEBI:"glutamate(1-)") increases act(a(GO:"excitatory synapse")) - pmid:17293005 + pubmed:28745240 - p(HGNC:BACE1, frag("230_235")) causesNoChange sec(a(HBP:"sAPP-beta")) + a(CHEBI:"glutamate(1-)") increases act(complex(GO:"NF-kappaB complex")) - pmid:17293005 + pubmed:28745240 - p(HGNC:BACE1, frag("230_235")) causesNoChange sec(a(HBP:"sAPP-alpha")) + a(CHEBI:"glutamate(1-)") increases path(CONSO:Excitotoxicity) - pmid:17293005 + pubmed:25652642 - p(HGNC:BACE1, frag("230_235")) causesNoChange a(CHEBI:"amyloid-beta") + a(CHEBI:"glutamate(1-)") increases act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) - pmid:17293005 + pubmed:25652642 - p(HGNC:BACE1, frag("230_235")) causesNoChange p(HGNC:ACTB) + a(CHEBI:"glutamate(1-)") increases act(complex(p(HGNC:NFKB1), p(HGNC:RELA))) - - - - - pmid:21214928 + pubmed:16273023 - rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) association p(HGNC:BACE2) + a(CHEBI:"glutamate(1-)") association path(MESH:D013850) - pmid:21214928 + pubmed:16273023 - a(MESH:"Amyloid Precursor Protein Secretases") increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) + a(CHEBI:"glutamate(1-)") association path(MESH:D008568) - pmid:26813123 + pubmed:27087442 - a(MESH:"Amyloid Precursor Protein Secretases") decreases a(MESH:"Amyloid beta-Peptides") + a(CHEBI:"glutamate(1-)") increases p(CONSO:"CDK5R1 p25") - pmid:14556719 + pubmed:28745240 - a(MESH:"Amyloid Precursor Protein Secretases") increases rxn(reactants(p(HGNC:APP)), products(a(MESH:"Amyloid beta-Peptides"))) + act(a(GO:"excitatory synapse")) increases act(complex(GO:"NF-kappaB complex")) - pmid:21214928 + pubmed:28745240 - a(MESH:Caspases) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) + act(a(GO:"excitatory synapse")) increases act(complex(GO:"NF-kappaB complex")) - pmid:21214928 + pubmed:28745240 - a(MESH:Caspases) increases path(MESH:"Alzheimer Disease") + act(a(GO:"excitatory synapse")) increases act(complex(GO:"NF-kappaB complex")) - pmid:21214928 + pubmed:28745240 - a(MESH:Caspases) increases rxn(reactants(p(HBP:HBP00071)), products(a(HBP:HBP00069), a(HBP:HBP00070))) + path(CONSO:Excitotoxicity) increases bp(GO:"neuron death") - pmid:21214928 + pubmed:19419557 - a(MESH:Caspases) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00069))) + path(CONSO:Excitotoxicity) increases bp(GO:"neuron apoptotic process") - pmid:21214928 + pubmed:30012004 - a(MESH:Caspases) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00070))) + path(CONSO:Excitotoxicity) positiveCorrelation path(MESH:"Huntington Disease") - pmid:22122372 + pubmed:30027901 - a(MESH:Caspases) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00069), a(HBP:HBP00070))) + path(CONSO:Excitotoxicity) association path(MESH:"Huntington Disease") - pmid:29215007 + pubmed:21722302 - a(MESH:Caspases) increases p(HGNC:MAPT, var("?")) + path(CONSO:Excitotoxicity) increases bp(GO:"motor neuron apoptotic process") - pmid:21214928 + pubmed:24027553 - bp(HBP:HBP00077) increases p(HBP:HBP00063) + path(CONSO:Excitotoxicity) increases a(CHEBI:"calcium(2+)", loc(GO:intracellular)) - pmid:21214928 + pubmed:24027553 - bp(HBP:HBP00077) increases p(HBP:HBP00064) + path(CONSO:Excitotoxicity) association act(p(HGNCGENEFAMILY:Calpains)) - pmid:21214928 + pubmed:27607061 - bp(HBP:HBP00077) increases p(HBP:HBP00065) + path(CONSO:Excitotoxicity) negativeCorrelation tloc(p(HGNC:GRIK2), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) - pmid:22122372 + pubmed:28745240 - bp(HBP:HBP00077) increases a(HBP:HBP00063) + a(MESH:"Receptors, N-Methyl-D-Aspartate") regulates bp(GO:"calcium ion import") - pmid:22122372 + pubmed:28745240 - bp(HBP:HBP00077) increases a(HBP:HBP00064) + a(MESH:"Receptors, N-Methyl-D-Aspartate") regulates act(p(HGNC:CAMK2A)) - pmid:21214928 + pubmed:25652642 - p(HBP:HBP00064) association p(UNIPROT:A0A293M1A7) + a(MESH:"Receptors, N-Methyl-D-Aspartate") increases act(complex(p(HGNC:NFKB1), p(HGNC:RELA))) - pmid:21214928 + pubmed:21214928 - p(HBP:HBP00064) increases path(MESH:"Plaque, Amyloid") + a(MESH:"Receptors, N-Methyl-D-Aspartate") increases p(CONSO:CONSO00064) - pmid:21214928 + pubmed:22122372 - p(HBP:HBP00065) association p(UNIPROT:A0A293M1A7) + a(MESH:"Receptors, N-Methyl-D-Aspartate") increases p(CONSO:CONSO00064) - pmid:21214928 + pubmed:21214928 - p(HBP:HBP00065) increases path(MESH:"Plaque, Amyloid") + a(MESH:"Receptors, N-Methyl-D-Aspartate") increases p(CONSO:CONSO00065) - pmid:21214928 + pubmed:22122372 - p(HBP:HBP00065) positiveCorrelation path(MESH:"Alzheimer Disease") + a(MESH:"Receptors, N-Methyl-D-Aspartate") increases p(CONSO:CONSO00065) - pmid:21214928 + pubmed:21214928 - p(UNIPROT:A0A293M1A7) association p(HBP:HBP00064) + a(MESH:"Receptors, N-Methyl-D-Aspartate") increases a(CHEBI:amyloid-beta) - pmid:21214928 + pubmed:22122372 - p(UNIPROT:A0A293M1A7) association p(HBP:HBP00065) + a(MESH:"Receptors, N-Methyl-D-Aspartate") decreases p(CONSO:CONSO00063) - pmid:21214928 + pubmed:25514383 - r(HBP:HBP00064) positiveCorrelation path(MESH:"Alzheimer Disease") + a(MESH:"Receptors, N-Methyl-D-Aspartate") regulates tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + + - pmid:21214928 + pubmed:24653673 - bp(GO:"signal transduction") association p(HGNC:APP) + a(MESH:"Receptors, N-Methyl-D-Aspartate") association path(MESH:"Alzheimer Disease") + + - pmid:17403556 + pubmed:26751493 - bp(GO:"signal transduction") increases complex(a(HBP:"amyloid-beta derived diffusible ligands"), p(HGNC:MAPT)) + a(MESH:"Receptors, N-Methyl-D-Aspartate") association p(CONSO:"projection domain") - pmid:29311797 + pubmed:27796283 - bp(GO:"signal transduction") association p(HGNC:HSP90AB1) + a(MESH:"Receptors, N-Methyl-D-Aspartate") increases act(p(HGNC:RAC1)) - pmid:21214928 + pubmed:27796283 - bp(GO:"protein transport") association p(HGNC:APP) + a(MESH:"Receptors, N-Methyl-D-Aspartate") increases p(HGNC:TIAM1, pmod(go:0006468 ! "protein phosphorylation")) - pmid:23746257 + pubmed:22833681 - bp(GO:"protein transport") association p(FPLX:HSP90) + act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) increases p(CONSO:"Tau epitope, AT8") - - - - - pmid:22122372 + pubmed:22833681 - complex(a(CHEBI:"amyloid-beta"), p(HGNC:APP)) regulates bp(HBP:HBP00073) + act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) increases p(CONSO:"Tau epitope, PHF1") - - - - - pmid:22122372 + pubmed:22833681 - complex(p(HGNC:APP), p(HGNC:SPON1)) regulates bp(HBP:HBP00073) + act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) increases p(CONSO:"Tau epitope, AT180") - - - - - pmid:22122372 + pubmed:22833681 - complex(p(HGNC:APP), p(HGNC:NTN1)) regulates bp(HBP:HBP00073) + act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) decreases p(CONSO:"Tau epitope, AT100") - pmid:27068745 + pubmed:22833681 - p(HGNC:NTN1) decreases bp(GO:"neuron apoptotic process") + act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) positiveCorrelation path(CONSO:"Long-Term Depression") - pmid:21214928 + pubmed:22833681 - bp(GO:"anterograde axonal protein transport") association p(HGNC:APP) + act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) increases complex(p(HGNC:FYN), p(HGNC:MAPT)) - - - - - pmid:21214928 + pubmed:28745240 - complex(p(HGNC:APP), p(HGNC:KIF5B)) regulates act(p(HGNC:BACE1)) + bp(GO:"calcium ion import") increases act(complex(GO:"NF-kappaB complex")) - pmid:21214928 + pubmed:28745240 - complex(p(HGNC:APP), p(HGNC:KIF5B)) regulates act(p(HGNC:PSEN1)) + bp(GO:"calcium ion import") increases act(p(HGNC:CAMK2A)) - pmid:19491104 + pubmed:28745240 - p(HGNC:KIF5B) isA complex(GO:"kinesin complex") + bp(GO:"calcium ion import") increases act(p(FPLX:PKC)) - pmid:19491104 + pubmed:28745240 - p(HGNC:KIF5B) association complex(GO:microtubule) + bp(GO:"calcium ion import") increases act(complex(GO:"phosphatidylinositol 3-kinase complex")) - - - pmid:26813123 + pubmed:28745240 - complex(p(HGNC:APP), p(HGNC:SLC5A7)) increases tloc(p(HGNC:APP), fromLoc(GO:"cell surface"), toLoc(GO:intracellular)) + bp(GO:"calcium ion import") increases act(p(FPLX:AKT)) - - - - - - - pmid:21214928 + pubmed:27794524 - a(HBP:HBP00067) decreases bp(HBP:HBP00061) + bp(GO:"calcium ion import") increases path(MESH:"Energy Metabolism") - pmid:22122372 + pubmed:19419557 - a(HBP:HBP00067) decreases bp(HBP:HBP00061) + bp(GO:"calcium ion import") increases a(CHEBI:amyloid-beta) - pmid:22122372 + pubmed:19419557 - sec(a(HBP:HBP00067)) decreases bp(HBP:HBP00061) + bp(GO:"calcium ion import") association p(HGNC:CALHM1) - pmid:21214928 + pubmed:21871088 - a(HBP:HBP00067) negativeCorrelation path(MESH:"Alzheimer Disease") + bp(GO:"calcium ion import") increases bp(GO:"long-term synaptic depression") - pmid:21214928 + pubmed:21871088 - a(HBP:HBP00067) association bp(GO:"regulation of neuronal synaptic plasticity") + bp(GO:"calcium ion import") association bp(GO:"long-term synaptic depression") - pmid:21214928 + pubmed:21871088 - a(HBP:HBP00067) regulates bp(GO:"central nervous system formation") + bp(GO:"calcium ion import") association bp(GO:"long-term synaptic potentiation") - pmid:21214928 + pubmed:26813123 - a(HBP:HBP00067) decreases bp(HBP:HBP00068) + bp(GO:"calcium ion import") regulates act(p(HGNC:CHAT)) - pmid:21214928 + pubmed:26979166 - a(HBP:HBP00067) decreases bp(HBP:HBP00068) + bp(GO:"calcium ion import") increases tloc(a(CHEBI:neurotransmitter), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:21214928 + pubmed:28745240 - a(HBP:HBP00067) regulates bp(GO:"stem cell proliferation") + act(p(HGNC:CAMK2A)) increases act(complex(GO:"NF-kappaB complex")) - pmid:21214928 + pubmed:28745240 - a(HBP:HBP00067) decreases act(p(HGNC:CDK5)) + act(p(HGNC:CAMK2A)) increases act(complex(GO:"NF-kappaB complex")) - pmid:21214928 + pubmed:28745240 - a(HBP:HBP00067) association complex(p(HGNC:APBA1), p(HGNC:APP)) + act(p(HGNC:CAMK2A)) increases act(complex(GO:"IkappaB kinase complex")) - pmid:21214928 + pubmed:28745240 - sec(a(HBP:HBP00067)) association complex(p(HGNC:APBA1), p(HGNC:APP)) + act(p(HGNC:CAMK2A)) increases p(MESH:"I-kappa B Kinase", pmod(go:0006468 ! "protein phosphorylation")) - pmid:21214928 + pubmed:29661268 - a(HBP:HBP00067) association complex(p(HGNC:APBA2), p(HGNC:APP)) + act(p(HGNC:CAMK2A), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:21214928 + pubmed:26631930 - sec(a(HBP:HBP00067)) association complex(p(HGNC:APBA2), p(HGNC:APP)) + p(HGNC:CAMK2A) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:21214928 + pubmed:22122372 - a(HBP:HBP00067) association complex(p(HGNC:APBA3), p(HGNC:APP)) + p(HGNC:CAMK2A) increases p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Thr, 654)) - pmid:21214928 + pubmed:22122372 - sec(a(HBP:HBP00067)) association complex(p(HGNC:APBA3), p(HGNC:APP)) + p(HGNC:CAMK2A) increases p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Thr, 668)) - pmid:21214928 + pubmed:22122372 - sec(a(HBP:HBP00067)) association a(CHEBI:"phorbol ester") + p(HGNC:CAMK2A) increases p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Ser, 665)) + + - pmid:22122372 + pubmed:29428175 - a(HBP:HBP00067) increases bp(GO:"cell adhesion") + p(HGNC:CAMK2A) regulates a(GO:cytoskeleton) - pmid:22122372 + pubmed:26631930 - a(HBP:HBP00067) increases bp(MESH:"Neuronal Outgrowth") + p(HGNC:CAMK2A) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) - pmid:22122372 + pubmed:17493042 - a(HBP:HBP00067) increases bp(GO:"synapse assembly") + p(HGNC:CAMK2A) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser)) - pmid:22122372 + pubmed:28745240 - a(HBP:HBP00067) increases bp(GO:learning) + act(p(FPLX:PKC)) increases act(complex(GO:"NF-kappaB complex")) - pmid:22122372 + pubmed:28745240 - a(HBP:HBP00067) increases bp(GO:memory) + act(p(FPLX:PKC)) increases act(complex(GO:"NF-kappaB complex")) - - - - - - - pmid:21214928 + pubmed:28745240 - composite(a(CHEBI:"phorbol ester"), p(HGNC:ADAM9), p(HGNC:APP)) increases a(HBP:HBP00067) + act(p(FPLX:PKC)) increases act(complex(GO:"NF-kappaB complex")) - pmid:21214928 + pubmed:25652642 - a(CHEBI:"phorbol ester") association sec(a(HBP:HBP00067)) + act(p(FPLX:PKC)) increases act(complex(GO:"NF-kappaB complex")) - pmid:21214928 + pubmed:28745240 - a(CHEBI:"phorbol ester") association a(CHEBI:"amyloid-beta") + act(p(FPLX:PKC)) increases act(complex(GO:"IkappaB kinase complex")) - pmid:21214928 + pubmed:28745240 - a(CHEBI:"phorbol ester") increases act(p(HGNC:PRKCA)) + act(p(FPLX:PKC)) increases p(MESH:"I-kappa B Kinase", pmod(go:0006468 ! "protein phosphorylation")) - pmid:21214928 + pubmed:29179999 - bp(GO:"regulation of neuronal synaptic plasticity") association a(HBP:HBP00067) + act(p(FPLX:PKC)) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) - pmid:12428809 + pubmed:18650430 - bp(GO:"regulation of neuronal synaptic plasticity") association sec(p(HGNC:APP)) + p(FPLX:PKC) increases tloc(p(HGNC:APP), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - - - - - pmid:21214928 + pubmed:24590577 - complex(p(HGNC:BACE1), p(HGNC:RTN4)) decreases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) + act(p(FPLX:PKC)) increases tloc(p(HGNC:APP), fromLoc(GO:"Golgi apparatus"), toLoc(GO:"cell surface")) - - - pmid:21214928 + pubmed:26813123 - complex(p(HGNC:BACE1), p(HGNC:GGA1)) decreases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) + p(FPLX:PKC) increases p(HGNC:SLC18A3, pmod(go:0006468 ! "protein phosphorylation")) - pmid:19126755 + pubmed:26813123 - bp(GO:"synaptic transmission, cholinergic") increases bp(GO:cognition) + p(FPLX:PKC) increases p(FPLX:CHRN, pmod(go:0006468 ! "protein phosphorylation")) - pmid:24511233 + pubmed:24590577 - bp(GO:"synaptic transmission, cholinergic") association bp(GO:cognition) + act(p(FPLX:PKC)) increases act(p(HGNC:ADAM10)) - pmid:26813123 + pubmed:24590577 - bp(GO:"synaptic transmission, cholinergic") association bp(GO:cognition) + act(p(FPLX:PKC)) increases p(HGNC:BACE1) - pmid:21482353 + pubmed:24590577 - bp(GO:"synaptic transmission, cholinergic") association bp(GO:cognition) + act(p(FPLX:PKC)) decreases act(p(HGNC:GSK3B)) - pmid:19126755 + pubmed:17493042 - bp(GO:"synaptic transmission, cholinergic") negativeCorrelation path(MESH:"Alzheimer Disease") + p(FPLX:PKC) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 214)) - pmid:26813123 + pubmed:28745240 - bp(GO:"synaptic transmission, cholinergic") association path(MESH:"Alzheimer Disease") + act(complex(GO:"phosphatidylinositol 3-kinase complex")) increases act(complex(GO:"NF-kappaB complex")) - pmid:19293145 + pubmed:28745240 - bp(GO:"synaptic transmission, cholinergic") association a(CHEBI:"amyloid-beta") + act(complex(GO:"phosphatidylinositol 3-kinase complex")) increases act(complex(GO:"IkappaB kinase complex")) - pmid:19293145 + pubmed:28745240 - bp(GO:"synaptic transmission, cholinergic") association a(CHEBI:"amyloid-beta") + act(complex(GO:"phosphatidylinositol 3-kinase complex")) increases p(MESH:"I-kappa B Kinase", pmod(go:0006468 ! "protein phosphorylation")) - pmid:24511233 + pubmed:28745240 - bp(GO:"synaptic transmission, cholinergic") association bp(GO:behavior) + act(p(FPLX:AKT)) increases act(complex(GO:"NF-kappaB complex")) - pmid:24511233 + pubmed:28745240 - bp(GO:"synaptic transmission, cholinergic") association path(MESH:Schizophrenia) + act(p(FPLX:AKT)) increases act(complex(GO:"IkappaB kinase complex")) - pmid:17009926 + pubmed:28745240 - bp(GO:"synaptic transmission, cholinergic") increases act(a(CHEBI:acetylcholine)) + act(p(FPLX:AKT)) increases p(MESH:"I-kappa B Kinase", pmod(go:0006468 ! "protein phosphorylation")) - pmid:26813123 + pubmed:27288790 - bp(GO:"synaptic transmission, cholinergic") regulates act(a(MESH:Neurons)) + act(p(FPLX:AKT)) increases p(HGNC:RELA) - - - pmid:26813123 - - bp(GO:"synaptic transmission, cholinergic") association path(MESH:Attention) - + - pmid:26813123 + pubmed:30061532 - bp(GO:"synaptic transmission, cholinergic") increases path(MESH:Attention) + p(FPLX:AKT) regulates act(p(HGNC:MTOR)) - pmid:26813123 + pubmed:30061532 - bp(GO:"synaptic transmission, cholinergic") increases path(MESH:Attention) + act(p(FPLX:AKT)) increases act(p(HGNC:MTOR)) + + - pmid:26813123 + pubmed:19293145 - bp(GO:"synaptic transmission, cholinergic") association bp(GO:learning) + act(p(FPLX:AKT)) decreases bp(GO:"apoptotic process") - pmid:26813123 + pubmed:23454242 - bp(GO:"synaptic transmission, cholinergic") positiveCorrelation bp(GO:learning) + p(FPLX:AKT) regulates bp(GO:"apoptotic process") + + - pmid:21482353 + pubmed:19293145 - bp(GO:"synaptic transmission, cholinergic") association bp(GO:learning) + p(FPLX:AKT) association bp(GO:"insulin receptor signaling pathway") - pmid:26813123 + pubmed:25514383 - bp(GO:"synaptic transmission, cholinergic") association bp(GO:memory) + act(p(FPLX:AKT)) decreases bp(HP:Neurodegeneration) - pmid:21482353 + pubmed:30697142 - bp(GO:"synaptic transmission, cholinergic") association bp(GO:memory) + p(FPLX:AKT) decreases bp(GO:"programmed cell death") - pmid:22040696 + pubmed:30697142 - bp(GO:"synaptic transmission, cholinergic") increases bp(GO:memory) + act(p(FPLX:AKT)) increases p(HGNC:CREBBP) - pmid:26813123 + pubmed:30697142 - bp(GO:"synaptic transmission, cholinergic") association bp(GO:"response to stress") + act(p(FPLX:AKT)) increases p(HGNC:BCL2) - pmid:26813123 + pubmed:30697142 - bp(GO:"synaptic transmission, cholinergic") association bp(GO:"regulation of circadian sleep/wake cycle, wakefulness") + act(p(FPLX:AKT)) increases p(HGNC:MAP3K5) - pmid:26813123 + pubmed:30697142 - bp(GO:"synaptic transmission, cholinergic") association bp(GO:"regulation of circadian sleep/wake cycle, sleep") + act(p(FPLX:AKT)) decreases act(p(HGNC:MAPK8)) - pmid:26813123 + pubmed:30697142 - bp(GO:"synaptic transmission, cholinergic") association bp(GO:"sensory processing") + act(p(FPLX:AKT)) increases bp(MESH:Neuroprotection) - pmid:21482353 + pubmed:30697142 - bp(GO:"synaptic transmission, cholinergic") association bp(GO:"sensory processing") + act(p(FPLX:AKT)) decreases a(CHEBI:"amyloid-beta polypeptide 42") - pmid:26813123 + pubmed:30697142 - bp(GO:"synaptic transmission, cholinergic") regulates bp(GO:"circadian sleep/wake cycle") + act(p(FPLX:AKT)) decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:26813123 + doi:"10.4172/2168-975X.1000126" - bp(GO:"synaptic transmission, cholinergic") association bp(HBP:Neurodegeneration) + p(FPLX:AKT) increases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) - pmid:26813123 + pubmed:25331948 - bp(GO:"synaptic transmission, cholinergic") association path(MESH:Dementia) + p(FPLX:AKT) regulates p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) - pmid:24590577 + pubmed:29121589 - bp(GO:"synaptic transmission, cholinergic") association path(MESH:"Plaque, Amyloid") + p(FPLX:AKT) increases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) - pmid:24590577 + pubmed:29844403 - bp(GO:"synaptic transmission, cholinergic") association path(MESH:"Neurofibrillary Tangles") + p(FPLX:AKT) increases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) + + - pmid:21482353 + pubmed:23454242 - bp(GO:"synaptic transmission, cholinergic") association path(MESH:Anxiety) + p(FPLX:AKT) regulates bp(GO:"cell growth") - pmid:21482353 + pubmed:23454242 - bp(GO:"synaptic transmission, cholinergic") association path(MESH:Depression) + p(FPLX:AKT) regulates bp(GO:"cell population proliferation") + + - pmid:21482353 + pubmed:29121589 - bp(GO:"synaptic transmission, cholinergic") association p(HGNC:LYNX1) + p(FPLX:AKT) positiveCorrelation p(HGNC:NFE2L2) - pmid:11230871 + pubmed:29121589 - bp(GO:"synaptic transmission, cholinergic") association a(PUBCHEM:5662) + p(FPLX:AKT) regulates act(p(MGI:Gsk3b)) - pmid:21214928 + pubmed:28745240 - p(HGNC:APP, frag("672_713")) increases a(HBP:HBP00038) + act(complex(GO:"IkappaB kinase complex")) increases act(complex(GO:"NF-kappaB complex")) - pmid:21214928 + pubmed:28745240 - p(HGNC:APP, frag("672_713")) increases a(HBP:HBP00038) + p(MESH:"I-kappa B Kinase", pmod(go:0006468 ! "protein phosphorylation")) increases act(complex(GO:"IkappaB kinase complex")) + + - pmid:22122372 + pubmed:27889190 - p(HGNC:APP, frag("672_713")) increases a(HBP:HBP00038) + bp(GO:behavior) association path(DOID:"acute disseminated encephalomyelitis") - pmid:21214928 + pubmed:24511233 - p(HGNC:APP, frag("672_713")) increases path(MESH:"Alzheimer Disease") + bp(GO:behavior) association path(MESH:Schizophrenia) - pmid:21214928 + pubmed:24511233 - p(HGNC:APP, frag("672_713")) increases a(HBP:HBP00022) + bp(GO:behavior) association bp(GO:"synaptic transmission, cholinergic") - pmid:22122372 + pubmed:31248781 - p(HGNC:APP, frag("672_713")) increases a(HBP:HBP00022) + bp(GO:behavior) positiveCorrelation p(MESH:"Amyloid beta-Peptides", frag("1_?")) - pmid:21214928 + pubmed:23516100 - p(HGNC:APP, frag("672_713")) increases path(MESH:"Plaque, Amyloid") + bp(GO:behavior) negativeCorrelation p(GO:"neurofibrillary tangle") - pmid:22122372 + pubmed:26968346 - p(HGNC:APP, frag("672_713")) increases path(MESH:"Plaque, Amyloid") + bp(GO:behavior) positiveCorrelation act(p(MESH:Glucosylceramidase)) - pmid:22122372 + pubmed:26968346 - p(HGNC:APP, frag("672_713")) increases path(MESH:"Plaque, Amyloid") + bp(GO:behavior) positiveCorrelation p(HGNC:TFEB) - pmid:21722302 + pubmed:27299292 - p(HGNC:APP, frag("672_713")) isA a(MESH:"Amyloidogenic Proteins") + bp(GO:behavior) positiveCorrelation p(HGNC:TFEB) - pmid:21722302 + pubmed:27299292 - p(HGNC:APP, frag("672_713")) increases path(HP:"Senile plaques") + bp(GO:behavior) positiveCorrelation p(HGNC:TFEB) - pmid:27094130 + pubmed:28420982 - sec(p(HGNC:APP, frag("672_713"))) positiveCorrelation act(p(HGNC:DAPK1), ma(kin)) + bp(GO:behavior) association p(HGNC:MAPT) - pmid:29540553 + pubmed:22950410 - p(HGNC:APP, frag("672_713")) decreases p(MGI:Sirt3) + path(MESH:Anxiety) association p(HGNC:CRHR1) - pmid:29559585 + pubmed:17009926 - p(HGNC:APP, frag("672_713")) increases p(MGI:Mapt, pmod(Ac, Lys, 280)) + path(MESH:Anxiety) association p(FPLX:CHRN) - pmid:29559585 + pubmed:11230871 - p(HGNC:APP, frag("672_713")) increases a(CHEBI:"nitric oxide") + path(MESH:Anxiety) association p(FPLX:CHRN) - pmid:22122372 + pubmed:21482353 - p(HGNC:APP, frag("672_711")) decreases bp(HBP:HBP00061) + path(MESH:Anxiety) association bp(GO:"synaptic transmission, cholinergic") - pmid:24401760 + pubmed:28901280 - p(HGNC:APP, frag("672_711")) positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:Anxiety) association p(MESH:"Receptors, Nicotinic") - pmid:21214928 + pubmed:28775333 - path(MESH:"Down Syndrome") increases a(HBP:HBP00018) + path(MESH:Anxiety) positiveCorrelation p(MGI:Dyrk1a) - pmid:17009926 + pubmed:28745240 - path(MESH:"Down Syndrome") negativeCorrelation act(p(FPLX:CHRN)) + act(p(HGNC:PRKACA)) increases act(p(HGNC:CREB1)) - pmid:17009926 + pubmed:21214928 - path(MESH:"Down Syndrome") negativeCorrelation p(FPLX:CHRN) + p(HGNC:PRKACA) decreases a(CHEBI:amyloid-beta) - pmid:26813123 + pubmed:26979166 - path(MESH:"Down Syndrome") negativeCorrelation a(MESH:"Cholinergic Neurons") + act(p(HGNC:PRKACA)) directlyIncreases bp(GO:"protein kinase A signaling") - pmid:22299660 + pubmed:26979166 - path(MESH:"Down Syndrome") negativeCorrelation p(FPLX:PPP2) + act(p(HGNC:PRKACA)) increases p(HGNC:CHRNA7, pmod(go:0006468 ! "protein phosphorylation", Ser, 365)) - pmid:22908190 + pubmed:26979166 - path(MESH:"Down Syndrome") negativeCorrelation bp(GO:"regulation of endosome size") + p(HGNC:PRKACA) increases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) - pmid:28137862 + pubmed:26979166 - path(MESH:"Down Syndrome") association p(HGNC:DYRK1A) + p(HGNC:PRKACA) increases p(HGNC:CREB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 133)) - pmid:28250274 + pubmed:8282104 - path(MESH:"Down Syndrome") negativeCorrelation p(HGNC:MME) + p(HGNC:PRKACA) association a(GO:microtubule) - pmid:21214928 + pubmed:8282104 - p(HGNC:CTSB) increases a(CHEBI:"amyloid-beta") + p(HGNC:PRKACA) association a(CONSO:CONSO00006) - pmid:22122372 + pubmed:17493042 - p(HGNC:CTSB) increases deg(a(CHEBI:"amyloid-beta")) + p(HGNC:PRKACA) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser)) - pmid:22908190 + pubmed:28745240 - p(HGNC:CTSB) positiveCorrelation act(a(GO:synapse)) + act(p(HGNC:CREB1)) increases bp(GO:"long-term memory") @@ -50236,1648 +50702,1604 @@

Statements

+ + - pmid:21214928 + pubmed:21677163 - complex(a(HBP:HBP00042), p(HGNC:TNFRSF21)) association bp(GO:"synapse pruning") + bp(GO:"long-term memory") positiveCorrelation p(FPLX:CREB) - pmid:21214928 + pubmed:28745240 - complex(a(HBP:HBP00042), p(HGNC:TNFRSF21)) association bp(GO:"neuron death") + bp(GO:"calcium ion homeostasis") increases act(complex(GO:"NF-kappaB complex")) - pmid:21214928 + pubmed:21214928 - a(HBP:HBP00042) increases p(HGNC:TTR) + bp(GO:"calcium ion homeostasis") association p(HGNC:APP) - pmid:21214928 + pubmed:19293145 - a(HBP:HBP00042) increases p(HGNC:KL) + bp(GO:"calcium ion homeostasis") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:22122372 + pubmed:23516100 - a(HBP:HBP00042) increases bp(HBP:HBP00061) + bp(GO:"calcium ion homeostasis") negativeCorrelation path(DOID:"Alzheimer's disease") - pmid:21214928 + pubmed:23516100 - bp(GO:"synapse pruning") association complex(a(HBP:HBP00042), p(HGNC:TNFRSF21)) + bp(GO:"calcium ion homeostasis") negativeCorrelation path(DOID:"Parkinson's disease") - pmid:21214928 + pubmed:23516100 - a(HBP:HBP00024) increases bp(HBP:HBP00027) + bp(GO:"calcium ion homeostasis") negativeCorrelation path(DOID:"Huntington's disease") - - - - - - - - - pmid:22122372 + pubmed:23516100 - act(p(HBP:HBP00071)) association p(HBP:HBP00071, pmod(Ph, Thr, 654)) + bp(GO:"calcium ion homeostasis") negativeCorrelation bp(CONSO:"Glutamate excitotoxicity") - - - pmid:22122372 + pubmed:23516100 - act(p(HBP:HBP00071)) association p(HBP:HBP00071, pmod(Ph, Thr, 668)) + bp(GO:"calcium ion homeostasis") negativeCorrelation path(DOID:"neurodegenerative disease") - - - pmid:22122372 + pubmed:20556492 - act(p(HBP:HBP00071)) association p(HBP:HBP00071, pmod(Ph, Ser, 665)) + bp(GO:"calcium ion homeostasis") association act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) - pmid:22122372 + pubmed:21722302 - p(HBP:HBP00071) increases bp(GO:"cell death") + bp(GO:"calcium ion homeostasis") increases p(MESH:"Molecular Chaperones", loc(GO:"endoplasmic reticulum")) - pmid:22122372 + pubmed:21722302 - p(HBP:HBP00071) increases p(HGNC:TP53) + bp(GO:"calcium ion homeostasis") increases act(p(MESH:"Molecular Chaperones", loc(GO:"endoplasmic reticulum"))) - pmid:22122372 + pubmed:21722302 - p(HBP:HBP00071) increases act(p(HGNC:TP53)) + bp(GO:"calcium ion homeostasis") increases bp(GO:"protein folding") - pmid:22122372 + pubmed:21722302 - p(HBP:HBP00071) regulates bp(GO:"calcium ion homeostasis") + bp(GO:"calcium ion homeostasis") increases bp(MESH:"Unfolded Protein Response") - pmid:22122372 + pubmed:29758300 - a(HBP:HBP00069) increases bp(HBP:HBP00061) + bp(GO:"calcium ion homeostasis") association p(HGNC:PSEN1) - pmid:22122372 + pubmed:28745240 - a(HBP:HBP00069) increases act(p(HGNC:CASP3)) + bp(MESH:"Oxidative Stress") association a(CHEBI:amyloid-beta) - pmid:22122372 + pubmed:28745240 - a(HBP:HBP00069) increases p(HGNC:APP, frag("672_713")) + bp(MESH:"Oxidative Stress") increases act(complex(GO:"NF-kappaB complex")) - pmid:22122372 + pubmed:28745240 - a(HBP:HBP00070) increases bp(HBP:HBP00061) + bp(MESH:"Oxidative Stress") increases act(complex(GO:"NF-kappaB complex")) - - - - - - - - - - - - - pmid:21214928 + pubmed:28745240 - complex(p(HGNC:APP), p(HGNC:NCSTN), p(HGNC:NOTCH1)) increases complex(complex(FPLX:"Gamma_secretase"), p(HGNC:APP)) + bp(MESH:"Oxidative Stress") increases act(complex(GO:"NF-kappaB complex")) - - - - - - - pmid:21214928 + pubmed:28745240 - p(HGNC:BSG) decreases a(CHEBI:"amyloid-beta") + bp(MESH:"Oxidative Stress") increases bp(GO:"apoptotic process") - pmid:21214928 + pubmed:25652642 - p(HGNC:BSG) causesNoChange a(CHEBI:"amyloid-beta") + bp(MESH:"Oxidative Stress") increases bp(GO:"apoptotic process") - pmid:21214928 + pubmed:27623715 - p(HGNC:TMED10) regulates a(CHEBI:"amyloid-beta") + bp(MESH:"Oxidative Stress") causesNoChange bp(GO:"apoptotic process") - - - - - - - pmid:21214928 + pubmed:14970312 - complex(a(HBP:HBP00024), complex(FPLX:"Gamma_secretase"), p(HGNC:GSAP)) increases a(CHEBI:"amyloid-beta") + bp(MESH:"Oxidative Stress") association path(MESH:"Alzheimer Disease") - - - - - - - - - pmid:30061532 + pubmed:22020111 - p(HGNC:ERBB4) association path(MESH:Schizophrenia) + bp(MESH:"Oxidative Stress") positiveCorrelation path(MESH:"Alzheimer Disease") - - - pmid:21718217 + pubmed:26195256 - p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta")) + bp(MESH:"Oxidative Stress") increases path(MESH:"Alzheimer Disease") - pmid:26195256 + pubmed:14970312 - p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta", loc(GO:"extracellular region"))) + bp(MESH:"Oxidative Stress") association bp(GO:"regulation of lipid metabolic process") - pmid:29626319 + pubmed:14970312 - p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta")) + bp(MESH:"Oxidative Stress") increases a(CHEBI:ceramide) - pmid:29626319 + pubmed:26979166 - p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta")) + bp(MESH:"Oxidative Stress") increases bp(MESH:Apoptosis) - pmid:29626319 + pubmed:18986241 - p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta")) + bp(MESH:"Oxidative Stress") association act(p(HGNC:PLCG1)) - pmid:29626319 + pubmed:18986241 - p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta")) + bp(MESH:"Oxidative Stress") association path(MESH:Aging) - pmid:29626319 + pubmed:26195256 - act(p(HGNC:MME)) increases deg(a(CHEBI:"amyloid-beta")) + bp(MESH:"Oxidative Stress") increases path(MESH:Aging) - pmid:28250274 + pubmed:18986241 - p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta")) + bp(MESH:"Oxidative Stress") association path(MESH:"Nerve Degeneration") - pmid:30116051 + pubmed:22020111 - p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta polypeptide 42")) + bp(MESH:"Oxidative Stress") positiveCorrelation path(MESH:"Colorectal Neoplasms") - pmid:30116051 + pubmed:21722302 - act(p(HGNC:MME)) decreases path(MESH:"Plaque, Amyloid") + bp(MESH:"Oxidative Stress") increases bp(GO:"motor neuron apoptotic process") - pmid:29626319 + pubmed:26195256 - p(HGNC:MME) increases bp(GO:behavior) + bp(MESH:"Oxidative Stress") decreases bp(GO:"establishment of blood-brain barrier") - pmid:28250274 + pubmed:21131359 - p(HGNC:MME) negativeCorrelation path(MESH:"Down Syndrome") + bp(MESH:"Oxidative Stress") increases tloc(p(HGNC:MAPT), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) - pmid:28250274 + pubmed:27623715 - p(HGNC:MME) negativeCorrelation p(HGNC:DYRK1A) + bp(MESH:"Oxidative Stress") increases act(p(FPLX:JNK)) - pmid:24653673 + pubmed:27623715 - p(HGNC:EGFR) increases p(HGNC:PPP2CA, pmod(Ph, Tyr, 307)) + bp(MESH:"Oxidative Stress") increases act(a(MESH:"Microtubule-Associated Proteins")) - pmid:24653673 + pubmed:27623715 - p(HGNC:EGFR) increases p(HGNC:PPP2CB, pmod(Ph, Tyr, 307)) + bp(MESH:"Oxidative Stress") increases a(CHEBI:"calcium(2+)") - pmid:30640040 + pubmed:27623715 - p(HGNC:EGFR) association a(PUBCHEM:24756910) + bp(MESH:"Oxidative Stress") decreases p(HGNC:S100B) - pmid:26195256 + pubmed:27623715 - p(HGNC:LRP1) increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:Brain), toLoc(MESH:Blood)) + bp(MESH:"Oxidative Stress") causesNoChange path(MESH:"Acidosis, Lactic") - pmid:26195256 + pubmed:27623715 - p(HGNC:LRP1) increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:Brain)) + bp(MESH:"Oxidative Stress") causesNoChange bp(GO:"amyloid fibril formation") - pmid:26195256 + pubmed:23722080 - p(HGNC:LRP1) increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Cardiovascular System")) + bp(MESH:"Oxidative Stress") decreases a(GO:mitochondrion) - pmid:29626319 + pubmed:24355211 - p(HGNC:LRP1) increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:Brain), toLoc(MESH:Blood)) + bp(MESH:"Oxidative Stress") positiveCorrelation p(HGNC:GSK3B) - pmid:29626319 + pubmed:8226987 - p(HGNC:LRP1) increases deg(a(CHEBI:"amyloid-beta")) + bp(MESH:"Oxidative Stress") increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:29626319 + pubmed:7667312 - p(HGNC:LRP1) increases deg(a(CHEBI:"amyloid-beta")) + bp(MESH:"Oxidative Stress") increases a(CONSO:"paired helical filaments") - pmid:26195256 + pubmed:28745240 - p(HGNC:LRP1) negativeCorrelation path(MESH:"Alzheimer Disease") + bp(GO:"JNK cascade") increases bp(GO:"apoptotic process") - pmid:26195256 + pubmed:28745240 - p(HGNC:LRP1) increases tloc(p(HGNC:APOE), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Cardiovascular System")) + bp(GO:"JNK cascade") increases act(complex(GO:"NF-kappaB complex")) - - - - - - - - - - - - - pmid:21214928 + pubmed:21722302 - complex(a(HBP:HBP00069), p(HGNC:APP)) increases bp(HBP:HBP00061) + bp(GO:"JNK cascade") increases bp(GO:autophagy) - pmid:22122372 + pubmed:21722302 - bp(GO:"neurofibrillary tangle assembly") association p(HGNC:MAPT, pmod(Ph)) + bp(GO:"JNK cascade") regulates bp(GO:autophagy) - pmid:22122372 + pubmed:21722302 - bp(GO:"neurofibrillary tangle assembly") association path(MESH:"Alzheimer Disease") + bp(GO:"JNK cascade") increases p(HGNC:BCL2, pmod(go:0006468 ! "protein phosphorylation")) - pmid:28420982 + pubmed:21722302 - bp(GO:"neurofibrillary tangle assembly") association a(MESH:"Heparan Sulfate Proteoglycans") + bp(GO:"JNK cascade") negativeCorrelation p(HGNC:PRKN) - pmid:19363271 + pubmed:30740335 - bp(GO:"neurofibrillary tangle assembly") positiveCorrelation p(FPLX:HSP90) + bp(GO:"JNK cascade") increases p(HBP:"amyloid-beta aggregates") - pmid:17050703 + pubmed:28745240 - bp(GO:"neurofibrillary tangle assembly") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) + bp(GO:"Fas signaling pathway") increases bp(GO:"apoptotic process") - pmid:22122372 + pubmed:28745240 - a(HBP:HBP00038) increases path(MESH:"Plaque, Amyloid") + bp(GO:"Fas signaling pathway") increases act(complex(GO:"NF-kappaB complex")) - pmid:21718217 + pubmed:28745240 - a(HBP:HBP00038) increases p(HGNC:CCL2) + p(HGNC:BCL2L1) increases tloc(a(PUBCHEM:16057918), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:21718217 + pubmed:28745240 - a(HBP:HBP00038) increases bp(GO:"microglial cell activation") + p(HGNC:BCL2L1) decreases bp(GO:"apoptotic process") - pmid:21718217 + pubmed:30444369 - act(a(HBP:HBP00038)) increases bp(GO:phagocytosis) + p(HGNC:BCL2L1) decreases bp(GO:"apoptotic process") - pmid:28019679 + pubmed:25652642 - a(HBP:HBP00038) increases act(complex(GO:"NLRP3 inflammasome complex")) + act(p(HGNC:BCL2L1)) decreases act(a(CHEBI:amyloid-beta)) - pmid:24561250 + pubmed:28745240 - a(HBP:HBP00038) increases act(complex(GO:"NLRP3 inflammasome complex")) + p(HGNC:BCL2) decreases bp(GO:"apoptotic process") - pmid:21718217 + pubmed:25652642 - a(HBP:HBP00022) decreases bp(GO:"synaptic signaling") + p(HGNC:BCL2) decreases bp(GO:"apoptotic process") - pmid:21718217 + pubmed:30444369 - a(HBP:HBP00022) increases bp(GO:"neuron death") + p(HGNC:BCL2) decreases bp(GO:"apoptotic process") - - - - - pmid:21214928 + pubmed:22530628 - complex(a(CHEBI:"amyloid-beta"), p(HGNC:DNM1)) decreases bp(HBP:HBP00061) + act(p(HGNC:BCL2)) increases bp(MESH:"Cell Survival") - pmid:19721446 + pubmed:30697142 - p(HGNC:DNM1) association p(HGNC:CHRNB2) + p(HGNC:BCL2) decreases bp(GO:"programmed cell death") + + - pmid:29590627 + pubmed:21722302 - act(p(HGNC:DNM1)) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + p(HGNC:BCL2) association bp(MESH:"Endoplasmic Reticulum Stress") - pmid:29590627 + pubmed:21722302 - act(p(HGNC:DNM1)) increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + p(HGNC:BCL2) decreases bp(MESH:Apoptosis) - pmid:29590627 + pubmed:21722302 - act(p(HGNC:DNM1)) increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + p(HGNC:BCL2) decreases bp(MESH:Apoptosis) - pmid:21214928 + pubmed:21722302 - a(MESH:"Potassium Channels") association a(CHEBI:"amyloid-beta") + p(HGNC:BCL2) regulates bp(GO:"calcium ion homeostasis") - - - pmid:21214928 + pubmed:30740335 - complex(p(HGNC:APBA1), p(HGNC:APP)) regulates bp(GO:"protein transport") + p(HGNC:BCL2) decreases path(MESH:Apoptosis) - - - pmid:21214928 - - complex(p(HGNC:APBA1), p(HGNC:APP)) association a(HBP:HBP00067) - - - pmid:21214928 + pubmed:23528736 - complex(p(HGNC:APBA1), p(HGNC:APP)) association sec(a(HBP:HBP00067)) + p(HGNC:BCL2) decreases bp(GO:autophagy) - - - pmid:21214928 - - complex(p(HGNC:APBA1), p(HGNC:APP)) association a(CHEBI:"amyloid-beta") - + - pmid:21214928 + pubmed:28745240 - complex(p(HGNC:APBA1), p(HGNC:APP)) association sec(a(CHEBI:"amyloid-beta")) + p(HGNC:BCL2A1) decreases bp(GO:"apoptotic process") - - - - - pmid:21214928 + pubmed:28745240 - complex(p(HGNC:APBA2), p(HGNC:APP)) regulates bp(GO:"protein transport") + a(CHEBI:etoposide) increases bp(GO:"apoptotic process") - pmid:21214928 + pubmed:29196815 - complex(p(HGNC:APBA2), p(HGNC:APP)) association a(HBP:HBP00067) + a(MESH:"Amyloid beta-Peptides") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:21214928 + pubmed:22122372 - complex(p(HGNC:APBA2), p(HGNC:APP)) association sec(a(HBP:HBP00067)) + a(MESH:"Amyloid beta-Peptides") association path(MESH:"Alzheimer Disease") - pmid:21214928 + pubmed:18650430 - complex(p(HGNC:APBA2), p(HGNC:APP)) association a(CHEBI:"amyloid-beta") + a(MESH:"Amyloid beta-Peptides") increases bp(GO:"cell adhesion") - pmid:21214928 + pubmed:22122372 - complex(p(HGNC:APBA2), p(HGNC:APP)) association sec(a(CHEBI:"amyloid-beta")) + a(MESH:"Amyloid beta-Peptides") association a(CONSO:CONSO00018) - - - pmid:21214928 + pubmed:31248781 - complex(p(HGNC:APBA3), p(HGNC:APP)) regulates bp(GO:"protein transport") + a(MESH:"Amyloid beta-Peptides") increases bp(MESH:Neuroprotection) - pmid:21214928 + pubmed:11230871 - complex(p(HGNC:APBA3), p(HGNC:APP)) association a(HBP:HBP00067) + a(MESH:"Amyloid beta-Peptides") negativeCorrelation p(FPLX:CHRN) - pmid:21214928 + pubmed:29758300 - complex(p(HGNC:APBA3), p(HGNC:APP)) association sec(a(HBP:HBP00067)) + a(MESH:"Amyloid beta-Peptides") association complex(GO:"gamma-secretase complex") - pmid:21214928 + pubmed:14556719 - complex(p(HGNC:APBA3), p(HGNC:APP)) association a(CHEBI:"amyloid-beta") + a(MESH:"Amyloid beta-Peptides") association path(MESH:"Plaque, Amyloid") + + + + - pmid:21214928 + pubmed:28745240 - complex(p(HGNC:APBA3), p(HGNC:APP)) association sec(a(CHEBI:"amyloid-beta")) + a(CHEBI:peroxynitrite) increases p(MESH:Proteins, pmod(CONSO:nitration)) - pmid:21214928 + pubmed:16566606 - p(HGNC:RAB6A) association bp(HBP:HBP00073) + a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(CONSO:nitration)) - pmid:21214928 + pubmed:21210655 - bp(GO:"clathrin-dependent endocytosis") increases deg(p(HGNC:APP)) + a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(CONSO:formylation, Lys)) - pmid:26751493 + pubmed:21210655 - bp(GO:"clathrin-dependent endocytosis") positiveCorrelation p(HGNC:MAPT) + a(CHEBI:peroxynitrite) increases bp(GO:"response to nitrosative stress") - pmid:26751493 + pubmed:16816118 - bp(GO:"clathrin-dependent endocytosis") isA tloc(a(HBP:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) + a(CHEBI:peroxynitrite) increases p(RGD:Mapt, pmod(CONSO:hyperphosphorylation)) - pmid:27260836 + pubmed:16816118 - bp(GO:"clathrin-dependent endocytosis") positiveCorrelation complex(p(HBP:"AP-2 complex"), p(HGNCGENEFAMILY:"Clathrin subunits")) + a(CHEBI:peroxynitrite) increases p(RGD:Mapt, pmod(CONSO:nitration)) - pmid:26751493 + pubmed:16816118 - bp(GO:"clathrin-dependent endocytosis") association p(HBP:"Tau oligomers") + a(CHEBI:peroxynitrite) increases act(p(RGD:Gsk3b)) - - - - - pmid:21214928 + pubmed:16816118 - complex(p(HGNC:PLD1), p(HGNC:PSEN1)) increases p(HGNC:APP) + a(CHEBI:peroxynitrite) increases act(p(RGD:Mapk14)) - - - - - - - - - pmid:21214928 + pubmed:16816118 - complex(p(HGNC:APP), p(HGNC:LRP1)) decreases p(HGNC:APP) + a(CHEBI:peroxynitrite) increases act(p(RGD:Mapk11)) - - - pmid:21214928 + pubmed:16816118 - complex(p(HGNC:APP), p(HGNC:LRP1)) increases a(CHEBI:"amyloid-beta") + a(CHEBI:peroxynitrite) increases act(p(RGD:Mapk13)) - + + + pubmed:16816118 + + a(CHEBI:peroxynitrite) causesNoChange act(p(RGD:Mapk12)) + - pmid:21214928 + pubmed:16816118 - complex(p(HGNC:APP), p(HGNC:LRP1B)) decreases a(CHEBI:"amyloid-beta") + a(CHEBI:peroxynitrite) causesNoChange act(p(FPLX:ERK)) - pmid:21214928 + pubmed:16816118 - complex(p(HGNC:APP), p(HGNC:LRP1B)) increases sec(a(HBP:HBP00067)) + a(CHEBI:peroxynitrite) causesNoChange act(p(FPLX:JNK)) - pmid:21214928 + pubmed:16816118 - a(CHEBI:estrogen) decreases a(CHEBI:"amyloid-beta") + a(CHEBI:peroxynitrite) increases a(CONSO:"Tau aggregates") - pmid:19293145 + pubmed:16566606 - a(CHEBI:estrogen) decreases act(a(CHEBI:"amyloid-beta")) + a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 18)) - pmid:11230871 + pubmed:16566606 - a(CHEBI:estrogen) decreases act(a(CHEBI:"amyloid-beta")) + a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) - pmid:21214928 + pubmed:16566606 - a(CHEBI:estrogen) increases sec(a(HBP:HBP00067)) + a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 197)) - pmid:19293145 + pubmed:16566606 - a(CHEBI:estrogen) decreases act(p(HBP:"APOE e4")) + a(CHEBI:peroxynitrite) increases p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 394)) - pmid:11230871 + pubmed:16566606 - a(CHEBI:estrogen) decreases path(MESH:"Alzheimer Disease") + a(CHEBI:peroxynitrite) increases a(CONSO:"3-3 dityrosine cross-linking") - pmid:21214928 + pubmed:27314526 - act(p(HGNC:PRKCA)) increases sec(a(HBP:HBP00067)) + a(CHEBI:peroxynitrite) increases bp(GO:"DNA conformation change") - pmid:21214928 + pubmed:27314526 - p(HGNC:PRKCA) increases sec(a(HBP:HBP00067)) + a(CHEBI:peroxynitrite) decreases bp(GO:"energy reserve metabolic process") - pmid:21214928 + pubmed:28745240 - p(HGNC:PRKCA) decreases a(CHEBI:"amyloid-beta") + composite(a(CHEBI:"kainic acid"), complex(GO:"NF-kappaB complex")) regulates bp(MESH:Neuroprotection) - pmid:21214928 + pubmed:28745240 - p(HGNC:PRKCA) directlyIncreases p(HGNC:APP, pmod(Ph, Ser, 655)) + composite(a(CHEBI:"kainic acid"), complex(GO:"NF-kappaB complex")) decreases path(MESH:Ischemia) + + - pmid:22122372 + pubmed:30935091 - p(HGNC:PRKCA) increases p(HBP:HBP00071, pmod(Ph, Thr, 654)) + a(CHEBI:"kainic acid") increases path(DOID:"axonal neuropathy") - pmid:22122372 + pubmed:19293145 - p(HGNC:PRKCA) increases p(HBP:HBP00071, pmod(Ph, Thr, 668)) + bp(MESH:Neuroprotection) association p(HGNC:FYN) - pmid:22122372 + pubmed:19293145 - p(HGNC:PRKCA) increases p(HBP:HBP00071, pmod(Ph, Ser, 665)) + bp(MESH:Neuroprotection) association bp(GO:"calcium-mediated signaling") - pmid:21214928 + pubmed:19293145 - p(HGNC:RAB11A) decreases a(CHEBI:"amyloid-beta") + bp(MESH:Neuroprotection) association a(MESH:Calcineurin) - pmid:27181519 + pubmed:19293145 - p(HGNC:RAB11A) association g(HGNC:C9orf72) + bp(MESH:Neuroprotection) association p(HGNC:JAK2) - pmid:21214928 + pubmed:27190210 - a(CHEBI:testosterone) decreases path(MESH:"Plaque, Amyloid") + bp(MESH:Neuroprotection) association p(HGNC:CHRNA7) - pmid:21214928 + pubmed:19721446 - a(CHEBI:testosterone) decreases r(HGNC:BACE1) + bp(MESH:Neuroprotection) association p(HGNC:CHRNA7) - pmid:21214928 + pubmed:27190210 - a(CHEBI:testosterone) decreases p(HGNC:BACE1) + bp(MESH:Neuroprotection) association bp(GO:"synaptic transmission, cholinergic") - pmid:21214928 + pubmed:31248781 - a(CHEBI:testosterone) decreases act(p(HGNC:BACE1)) + bp(MESH:Neuroprotection) association complex(GO:"neurotransmitter receptor complex") - pmid:21214928 + pubmed:31248781 - a(CHEBI:testosterone) decreases p(HGNC:PSEN1) + bp(MESH:Neuroprotection) negativeCorrelation bp(GO:"stress-activated protein kinase signaling cascade") - pmid:22122372 + pubmed:31248781 - a(HBP:HBP00064) positiveCorrelation path(MESH:"Alzheimer Disease") + bp(MESH:Neuroprotection) negativeCorrelation act(p(MESH:Caspases)) - pmid:22122372 + pubmed:31248781 - a(HBP:HBP00078) association p(HGNC:APP) + bp(MESH:Neuroprotection) positiveCorrelation bp(MESH:"Cell Survival") - pmid:22122372 + pubmed:31248781 - a(HBP:HBP00078) increases complex(p(HGNC:APP), p(HGNC:APP)) + bp(MESH:Neuroprotection) association bp(CONSO:"PI3K-Akt signaling pathway") - pmid:22122372 + pubmed:31248781 - a(HBP:HBP00078) increases complex(p(HGNC:APLP1), p(HGNC:APLP1)) + bp(MESH:Neuroprotection) association p(HGNC:CREBBP) - pmid:22122372 + pubmed:19721446 - a(HBP:HBP00078) increases complex(p(HGNC:APLP2), p(HGNC:APLP2)) + bp(MESH:Neuroprotection) association a(CHEBI:nicotine) - pmid:22122372 + pubmed:21722302 - a(HBP:HBP00079) association p(HGNC:APP) + path(MESH:Ischemia) increases act(p(HGNC:PRKAA1)) - - - - - - - pmid:22122372 + pubmed:28745240 - a(HBP:HBP00065) positiveCorrelation path(MESH:"Alzheimer Disease") + composite(a(CHEBI:"linolenic acid"), complex(GO:"NF-kappaB complex")) regulates bp(MESH:Neuroprotection) - - - - - - - pmid:22122372 + pubmed:28745240 - composite(p(MGI:Aplp1), p(MGI:Aplp2), p(MGI:App)) decreases path(MESH:"Perinatal Death") + composite(a(CHEBI:"linolenic acid"), complex(GO:"NF-kappaB complex")) decreases path(MESH:Ischemia) - - - - - - - - - - - - - pmid:29221819 + pubmed:24653673 - p(MGI:App) positiveCorrelation p(MGI:Dyrk1a) + bp(GO:neurogenesis) negativeCorrelation act(p(HGNC:GSK3B)) - - - - - - - - - - - - - - - - - - - - - - - - - pmid:22122372 + pubmed:24653673 - p(HGNC:PSEN1, var("?")) increases p(HGNC:APP, frag("672_713")) + bp(GO:neurogenesis) negativeCorrelation act(p(HGNC:CDK5)) - pmid:29758300 + pubmed:24653673 - p(HGNC:PSEN1, var("?")) association path(MESH:"Alzheimer Disease") + bp(GO:neurogenesis) negativeCorrelation act(p(FPLX:ERK)) - pmid:22908190 + pubmed:26631930 - p(HGNC:PSEN1, var("?")) increases path(MESH:"Alzheimer Disease") + bp(GO:neurogenesis) association p(HGNC:MAPT) - pmid:29758300 + pubmed:26631930 - p(HGNC:PSEN1, var("?")) decreases act(a(MESH:"Vacuolar Proton-Translocating ATPases")) + bp(GO:neurogenesis) association p(HGNC:MAPT) - pmid:14556719 + pubmed:28745240 - p(HGNC:PSEN1, var("?")) association act(complex(GO:"gamma-secretase complex")) + p(HGNC:FGF2) increases act(complex(GO:"NF-kappaB complex")) - pmid:14556719 + pubmed:28745240 - p(HGNC:PSEN1, var("?")) increases a(CHEBI:"amyloid-beta") + p(HGNC:EGF) increases act(complex(GO:"NF-kappaB complex")) - pmid:22908190 + pubmed:30935091 - p(HGNC:PSEN1, var("?")) decreases bp(GO:"lysosomal protein catabolic process") + p(HGNC:EGF) increases p(HGNCGENEFAMILY:"Beta catenins", loc(GO:nucleus)) - pmid:22908190 + pubmed:23393546 - p(HGNC:PSEN1, var("?")) decreases act(a(HBP:Neurites)) + p(HGNC:EGF) increases bp(GO:"MAPK cascade") - pmid:22908190 + pubmed:28745240 - p(HGNC:PSEN1, var("?")) decreases bp(GO:"pH reduction") + p(HGNC:VEGFA) increases act(complex(GO:"NF-kappaB complex")) - pmid:22908190 + pubmed:21861815 - p(HGNC:PSEN1, var("?")) decreases act(a(MESH:Neurites)) + p(HGNC:VEGFA) increases bp(GO:"blood vessel development") - pmid:24027553 + pubmed:21861815 - p(HGNC:PSEN1, var("?")) increases path(MESH:"Alzheimer disease, familial, type 3") + p(HGNC:VEGFA) increases bp(GO:"blood vessel development") - pmid:22122372 + pubmed:21861815 - p(HGNC:PSEN2, var("?")) increases p(HGNC:APP, frag("672_713")) + p(HGNC:VEGFA) negativeCorrelation path(EFO:hypoxemia) - pmid:14556719 + pubmed:21861815 - p(HGNC:PSEN2, var("?")) association act(complex(GO:"gamma-secretase complex")) + act(p(HGNC:VEGFA)) negativeCorrelation path(DOID:"amyotrophic lateral sclerosis") - pmid:14556719 + pubmed:21861815 - p(HGNC:PSEN2, var("?")) increases a(CHEBI:"amyloid-beta") + p(HGNC:VEGFA) decreases path(DOID:"amyotrophic lateral sclerosis") - + + + pubmed:21861815 + + p(HGNC:VEGFA) increases a(MESH:"Dopaminergic Neurons") + - + + + pubmed:21861815 + + p(HGNC:VEGFA) decreases bp(GO:"cell death") + - pmid:22122372 + pubmed:26304819 - a(MESH:"Receptors, Cell Surface") association p(HGNC:APP) + p(HGNC:VEGFA) biomarkerFor path(MESH:"Alzheimer Disease") + + + pubmed:28745240 + + p(HGNC:EPO) increases act(complex(GO:"NF-kappaB complex")) + + - pmid:22122372 + pubmed:21861815 - complex(p(HGNC:APP), p(HGNC:RTN4R)) regulates bp(HBP:HBP00073) + p(HGNC:EPO) decreases bp(GO:"neuron death") - + + + pubmed:21861815 + + p(HGNC:EPO) decreases act(a(CONSO:"amyloid-beta aggregates")) + - pmid:22122372 + pubmed:21861815 - complex(p(HGNC:APP), p(HGNC:ITM2B)) regulates bp(HBP:HBP00073) + p(HGNC:EPO) decreases a(CHEBI:oxidopamine) - + + + pubmed:28745240 + + path(MESH:"Cerebral Infarction") increases act(complex(GO:"NF-kappaB complex")) + - pmid:22122372 + pubmed:28745240 - complex(a(HBP:HBP00078), a(HBP:HBP00079)) increases complex(p(HGNC:APLP1), p(HGNC:APP)) + path(MESH:"Cerebral Infarction") increases bp(GO:neurogenesis) - pmid:22122372 + pubmed:28745240 - complex(a(HBP:HBP00078), a(HBP:HBP00079)) increases complex(p(HGNC:APLP2), p(HGNC:APP)) + path(MESH:"Brain Injuries, Traumatic") increases act(complex(GO:"NF-kappaB complex")) - pmid:22122372 + pubmed:28745240 - complex(a(HBP:HBP00078), a(HBP:HBP00079)) increases complex(p(HGNC:APP), p(HGNC:APP)) + path(MESH:"Brain Injuries, Traumatic") increases bp(GO:neurogenesis) - + + + pubmed:21722302 + + path(MESH:"Brain Injuries, Traumatic") association bp(CONSO:"protein aggregation") + - + + + pubmed:30126037 + + path(MESH:"Brain Injuries, Traumatic") association p(HGNC:MAPT) + - + + + pubmed:29626319 + + path(MESH:"Brain Injuries, Traumatic") increases p(HGNC:MAPT) + - pmid:22122372 + pubmed:26195256 - complex(p(HBP:HBP00042, frag("?")), p(HGNC:TNFRSF21)) increases bp(GO:"neuron death") + path(MESH:"Brain Injuries, Traumatic") association p(CONSO:"Tau aggregates") - pmid:22122372 + pubmed:29626319 - complex(p(HBP:HBP00042, frag("?")), p(HGNC:TNFRSF21)) increases bp(GO:"synapse pruning") + path(MESH:"Brain Injuries, Traumatic") decreases p(HGNC:AQP4) - - - + + + pubmed:29626319 + + path(MESH:"Brain Injuries, Traumatic") decreases act(p(HGNC:AQP4)) + - pmid:12428809 + pubmed:29626319 - p(HGNC:KLC1) increases bp(GO:"anterograde axonal transport") + path(MESH:"Brain Injuries, Traumatic") decreases p(HGNC:AQP4) - pmid:19491104 + pubmed:29626319 - act(p(HGNC:KLC1)) positiveCorrelation act(complex(GO:"kinesin complex")) + path(MESH:"Brain Injuries, Traumatic") decreases a(HP:"glymphatic system") - pmid:19491104 + pubmed:29626319 - p(HGNC:KLC1) isA complex(GO:"kinesin complex") + path(MESH:"Brain Injuries, Traumatic") decreases a(HP:"glymphatic system") - pmid:19491104 + pubmed:24561250 - p(HGNC:KLC1) association p(HGNC:MAPK8IP1) + path(MESH:"Brain Injuries, Traumatic") increases bp(GO:"cell death") - + + + pubmed:28745240 + + path(MESH:Hypoxia) increases act(complex(GO:"NF-kappaB complex")) + - + + + pubmed:28745240 + + path(MESH:Hypoxia) increases bp(GO:neurogenesis) + - + + + pubmed:21722302 + + path(MESH:Hypoxia) increases act(p(HGNC:PRKAA1)) + - + + + pubmed:28745240 + + p(CONSO:sAPP-alpha) increases act(complex(GO:"NF-kappaB complex")) + - + + + pubmed:28745240 + + p(CONSO:sAPP-alpha) increases bp(GO:neurogenesis) + - pmid:22122372 + pubmed:24590577 - complex(p(HBP:HBP00071), p(HGNC:APBA1)) decreases a(CHEBI:"amyloid-beta") + p(CONSO:sAPP-alpha) increases bp(MESH:Neuroprotection) - + + + pubmed:28745240 + + a(CHEBI:"sphingosine 1-phosphate") increases act(complex(GO:"NF-kappaB complex")) + - + + + pubmed:28745240 + + a(CHEBI:"sphingosine 1-phosphate") increases bp(GO:neurogenesis) + - pmid:22122372 + pubmed:28745240 - p(HBP:HBP00071, pmod(Ph, Thr, 654)) association bp(HBP:HBP00073) + a(CHEBI:"nitric oxide") decreases act(complex(GO:"NF-kappaB complex")) - pmid:22122372 + pubmed:28745240 - p(HBP:HBP00071, pmod(Ph, Thr, 654)) association act(p(HBP:HBP00071)) + a(CHEBI:"nitric oxide") decreases bp(GO:neurogenesis) - pmid:22122372 + pubmed:27794524 - p(HBP:HBP00071, pmod(Ph, Thr, 668)) association bp(HBP:HBP00073) + a(CHEBI:"nitric oxide") isA a(MESH:Neurotoxins) - pmid:22122372 + pubmed:27794524 - p(HBP:HBP00071, pmod(Ph, Thr, 668)) association act(p(HBP:HBP00071)) + a(CHEBI:"nitric oxide") decreases path(MESH:"Neural Conduction") - pmid:22122372 + pubmed:27794524 - p(HBP:HBP00071, pmod(Ph, Ser, 665)) association bp(HBP:HBP00073) + a(CHEBI:"nitric oxide") decreases bp(GO:"spinal cord development") - pmid:22122372 + pubmed:26445701 - p(HBP:HBP00071, pmod(Ph, Ser, 665)) association act(p(HBP:HBP00071)) + a(CHEBI:"nitric oxide") increases path(HP:"CNS demyelination") - pmid:22122372 + pubmed:26445701 - a(MESH:"JNK Mitogen-Activated Protein Kinases") increases p(HBP:HBP00071, pmod(Ph, Thr, 654)) + a(CHEBI:"nitric oxide") increases path(MESH:"Diffuse Axonal Injury") - pmid:22122372 + pubmed:26445701 - a(MESH:"JNK Mitogen-Activated Protein Kinases") increases p(HBP:HBP00071, pmod(Ph, Thr, 668)) + a(CHEBI:"nitric oxide") increases bp(GO:"positive regulation of oligodendrocyte apoptotic process") - pmid:22122372 + pubmed:30515821 - a(MESH:"JNK Mitogen-Activated Protein Kinases") increases p(HBP:HBP00071, pmod(Ph, Ser, 665)) + a(CHEBI:"nitric oxide") increases p(NCBIGENE:74006, pmod(go:0017014 ! "protein nitrosylation", Cys, 644)) - + + + pubmed:30515821 + + a(CHEBI:"nitric oxide") increases p(HGNC:DNM1, pmod(go:0017014 ! "protein nitrosylation", Cys, 644)) + @@ -51885,7675 +52307,7653 @@

Statements

- pmid:22122372 + pubmed:30515821 - complex(p(HBP:HBP00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:CD82) + a(CHEBI:"nitric oxide") increases p(NCBIGENE:74006, pmod(go:0017014 ! "protein nitrosylation")) - pmid:22122372 + pubmed:30515821 - complex(p(HBP:HBP00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:MME) + a(CHEBI:"nitric oxide") increases p(HGNC:DNM1L, pmod(go:0017014 ! "protein nitrosylation")) - pmid:22122372 + pubmed:30688256 - complex(p(HBP:HBP00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:TP53) + a(CHEBI:"nitric oxide") increases bp(GO:"mitochondrial fission") - pmid:22122372 + pubmed:29559585 - complex(p(HBP:HBP00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:GSK3B) + a(CHEBI:"nitric oxide") increases p(MGI:Gapdh, pmod(go:0017014 ! "protein nitrosylation")) - pmid:22122372 + pubmed:27601475 - complex(p(HBP:HBP00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:EGFR) + a(CHEBI:"nitric oxide") positiveCorrelation a(CONSO:8-nitro-cGMP) - pmid:22122372 + pubmed:23702978 - complex(p(HBP:HBP00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:LRP1) + a(CHEBI:"nitric oxide") increases p(HGNC:NLRP3, pmod(go:0017014 ! "protein nitrosylation")) - pmid:22122372 + pubmed:27314526 - act(p(HGNC:TP53)) increases bp(GO:"apoptotic process") + a(CHEBI:"nitric oxide") increases a(CHEBI:peroxynitrite) - - - - - - - pmid:22122372 + pubmed:27314526 - complex(p(HBP:HBP00071), p(HGNC:APBB1), p(HGNC:TFCP2)) increases p(HGNC:GSK3B) + a(CHEBI:"nitric oxide") increases act(p(HGNC:CASP3)) - - - - - pmid:22122372 + pubmed:27314526 - complex(p(HBP:HBP00071), p(HGNC:MAPK8IP1)) regulates p(HGNC:APP, pmod(Ph, Thr, 668)) + a(CHEBI:"nitric oxide") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:22122372 + pubmed:27314526 - complex(p(HBP:HBP00071), p(HGNC:MAPK8IP1)) association a(HBP:HBP00073) + a(CHEBI:"nitric oxide") increases bp(GO:"p38MAPK cascade") - pmid:19491104 + pubmed:28745240 - act(p(HGNC:MAPK8IP1)) positiveCorrelation act(complex(GO:"kinesin complex")) + path(HP:"Ischemic stroke") increases act(complex(GO:"NF-kappaB complex")) - pmid:19491104 + pubmed:28745240 - p(HGNC:MAPK8IP1) isA complex(GO:"kinesin complex") + path(HP:Seizures) increases act(complex(GO:"NF-kappaB complex")) - pmid:19491104 + pubmed:28745240 - p(HGNC:MAPK8IP1) association p(HGNC:KLC1) + a(MESH:"Cerebral Cortex") negativeCorrelation act(complex(GO:"NF-kappaB complex")) - pmid:27094130 + pubmed:24511233 - p(HGNC:APP, pmod(Ph, Thr, 668)) association bp(HBP:"APP processing") + a(MESH:"Cerebral Cortex") association bp(GO:cognition) - pmid:27094130 + pubmed:24511233 - p(HGNC:APP, pmod(Ph, Thr, 668)) regulates sec(p(HGNC:APP, frag("672_711"))) + a(MESH:"Cerebral Cortex") association bp(GO:learning) - pmid:27094130 + pubmed:24511233 - p(HGNC:APP, pmod(Ph, Thr, 668)) regulates sec(p(HGNC:APP, frag("672_713"))) + a(MESH:"Cerebral Cortex") association bp(GO:learning) - pmid:22122372 + pubmed:24511233 - a(HBP:HBP00073) association complex(p(HBP:HBP00071), p(HGNC:MAPK8IP1)) + a(MESH:"Cerebral Cortex") association bp(GO:memory) - - - - - pmid:22122372 + pubmed:24511233 - complex(p(HBP:HBP00071), p(HGNC:NAE1)) increases bp(GO:"protein neddylation") + a(MESH:"Cerebral Cortex") association bp(GO:memory) - pmid:22122372 + pubmed:24590577 - complex(p(HBP:HBP00071), p(HGNC:NAE1)) decreases p(HGNC:CTNNB1) + a(MESH:"Cerebral Cortex") association p(HGNC:CHRM1) - pmid:22122372 + pubmed:26195256 - complex(p(HBP:HBP00071), p(HGNC:NAE1)) increases bp(GO:"apoptotic process") + a(MESH:"Cerebral Cortex") negativeCorrelation path(MESH:"Alzheimer Disease") - - - pmid:18494933 + pubmed:28745240 - deg(p(HGNC:CTNNB1)) positiveCorrelation p(HGNC:DKK1) + p(HGNC:IL6) increases bp(GO:"astrocyte development") - - - - - - - - - + + + pubmed:28745240 + + p(HGNC:IL6) increases p(HGNC:STAT3) + - pmid:21722302 + pubmed:28745240 - p(MESH:Proteins, pmod(HBP:misfolded)) association bp(MESH:"Endoplasmic Reticulum Stress") + p(HGNC:IL6) increases a(MESH:"Transcription Factor AP-1") - pmid:21722302 + pubmed:28745240 - p(MESH:Proteins, pmod(HBP:misfolded)) increases act(p(HGNC:ERN1)) + p(HGNC:IL6) increases act(complex(GO:"NF-kappaB complex")) - pmid:21722302 + pubmed:28745240 - p(MESH:Proteins, pmod(HBP:misfolded)) increases act(p(MESH:"PERK kinase")) + p(HGNC:IL6) association path(MESH:"Alzheimer Disease") - pmid:21722302 + pubmed:25652642 - p(MESH:Proteins, pmod(HBP:misfolded)) increases act(p(HGNC:ATF6)) + p(HGNC:IL6) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:21722302 + pubmed:28745240 - p(MESH:Proteins, pmod(HBP:misfolded)) increases bp(HBP:"protein aggregation") + p(HGNC:IL6) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) - pmid:21722302 + pubmed:28745240 - p(MESH:Proteins, pmod(HBP:misfolded)) increases bp(HBP:"protein aggregation") + p(HGNC:IL6) increases bp(GO:"neuron death") - pmid:21722302 + pubmed:27794524 - p(MESH:Proteins, pmod(HBP:misfolded)) increases bp(MESH:"Unfolded Protein Response") + p(HGNC:IL6) isA a(MESH:Cytokines) - pmid:29311797 + pubmed:27794524 - deg(p(MESH:Proteins, pmod(HBP:misfolded))) association a(MESH:"Molecular Chaperones") + p(HGNC:IL6) positiveCorrelation path(MESH:"Complement Activation") - pmid:27181519 + pubmed:27794524 - p(MESH:Proteins, pmod(HBP:misfolded)) association path(MESH:"Prion Diseases") + p(HGNC:IL6) positiveCorrelation act(p(MESH:T-Lymphocytes)) - pmid:30061532 + pubmed:27794524 - act(p(HGNC:MTOR)) regulates deg(p(MESH:Proteins, pmod(HBP:misfolded))) + p(HGNC:IL6) directlyDecreases a(MESH:Oligodendroglia) - pmid:30061532 + pubmed:30967783 - act(p(HGNC:MTOR)) negativeCorrelation bp(GO:autophagy) + p(HGNC:IL6) increases bp(GO:"inflammatory response") - pmid:30061532 + pubmed:30967783 - act(p(HGNC:MTOR)) decreases bp(GO:autophagy) + p(HGNC:IL6) increases path(EFO:"experimental autoimmune encephalomyelitis") - pmid:30061532 + pubmed:30967783 - p(HGNC:MTOR) decreases bp(GO:autophagy) + p(HGNC:IL6) decreases path(EFO:"experimental autoimmune encephalomyelitis") - pmid:30106381 + pubmed:30967783 - p(HGNC:MTOR) association bp(GO:autophagy) + p(HGNC:IL6) increases path(DOID:"multiple sclerosis") - pmid:21722302 + pubmed:30967783 - p(HGNC:MTOR) regulates bp(GO:autophagy) + p(HGNC:IL6) increases path(MESH:Inflammation) - pmid:21722302 + pubmed:26979166 - act(p(HGNC:MTOR)) decreases bp(GO:autophagy) + p(HGNC:IL6) increases path(MESH:Inflammation) - pmid:21722302 + pubmed:30988501 - p(HGNC:MTOR) decreases bp(GO:autophagy) + p(HGNC:IL6) regulates path(MESH:Inflammation) - pmid:29758300 + pubmed:30967783 - p(HGNC:MTOR) negativeCorrelation bp(GO:autophagy) + p(HGNC:IL6) positiveCorrelation path(HP:Autoimmunity) - pmid:22908190 + pubmed:30988501 - p(HGNC:MTOR) regulates bp(GO:autophagy) + p(HGNC:IL6) increases a(MESH:"Neural Pathways") - pmid:18930136 + pubmed:30988501 - p(HGNC:MTOR) negativeCorrelation bp(GO:autophagy) + p(HGNC:IL6) increases act(a(MESH:Microglia)) - pmid:30061532 + pubmed:30988501 - act(p(HGNC:MTOR)) positiveCorrelation path(MESH:"Neurodegenerative Diseases") + p(HGNC:IL6) negativeCorrelation path(DOID:schizophrenia) - pmid:30061532 + pubmed:30988501 - act(p(HGNC:MTOR)) increases a(CHEBI:"amyloid-beta") + p(HGNC:IL6) negativeCorrelation path(DOID:"mental depression") - pmid:30061532 + pubmed:30988501 - act(p(HGNC:MTOR)) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + p(HGNC:IL6) negativeCorrelation path(DOID:"post-traumatic stress disorder") - pmid:30061532 + pubmed:30988501 - act(p(HGNC:MTOR)) increases path(MESH:"Alzheimer Disease") + p(HGNC:IL6) increases p(HGNC:IL17A) - pmid:30061532 + pubmed:28745240 - act(p(HGNC:MTOR)) increases a(HBP:"Tau aggregates") + a(MESH:"Transcription Factor AP-1") increases bp(GO:"astrocyte development") - pmid:30061532 + pubmed:28745240 - act(p(HGNC:MTOR)) decreases bp(GO:cognition) + p(HGNC:LIF) increases bp(GO:"astrocyte development") - pmid:30061532 + pubmed:28745240 - act(p(HGNC:MTOR)) association act(g(HGNC:DISC1)) + p(HGNC:LIF) increases p(HGNC:STAT3) - pmid:30061532 + pubmed:28745240 - act(p(HGNC:MTOR)) association act(g(HGNC:NRG1)) + p(HGNC:LIF) increases a(MESH:"Transcription Factor AP-1") - pmid:30061532 + pubmed:28745240 - act(p(HGNC:MTOR)) association act(g(HGNC:DPYSL2)) + p(HGNC:LIF) increases act(complex(GO:"NF-kappaB complex")) - pmid:30061532 + pubmed:28745240 - act(p(HGNC:MTOR)) increases act(a(CHEBI:methamphetamine)) + p(HGNC:CNTF) increases bp(GO:"astrocyte development") - pmid:30061532 + pubmed:28745240 - act(p(HGNC:MTOR)) association p(HGNC:MAP6) + p(HGNC:CNTF) increases p(HGNC:STAT3) - pmid:30061532 + pubmed:28745240 - act(p(HGNC:MTOR)) association p(HGNC:NRG1) + p(HGNC:CNTF) increases a(MESH:"Transcription Factor AP-1") - pmid:30061532 + pubmed:28745240 - act(p(HGNC:MTOR)) association path(MESH:Schizophrenia) + p(HGNC:CNTF) increases act(complex(GO:"NF-kappaB complex")) - pmid:30061532 + pubmed:28745240 - act(p(HGNC:MTOR)) negativeCorrelation path(MESH:Schizophrenia) + p(HGNC:CNTF) increases act(complex(GO:"NF-kappaB complex")) - pmid:30106381 + pubmed:28745240 - p(HGNC:MTOR) association bp(GO:translation) + p(HGNC:CNTF) increases bp(MESH:"Neuronal Outgrowth") - pmid:30106381 + pubmed:28745240 - p(HGNC:MTOR) association a(GO:"actin cytoskeleton") + p(HGNC:CNTF) increases act(p(HGNC:LCK)) - + + + pubmed:28745240 + + bp(MESH:"Neuronal Outgrowth") negativeCorrelation p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation", Ser, 536)) + - pmid:21722302 + pubmed:27288790 - p(HGNC:MTOR) negativeCorrelation p(HGNC:PRKAA1) + bp(MESH:"Neuronal Outgrowth") association p(FPLX:NFkappaB) - pmid:29758300 + pubmed:21214928 - p(HGNC:MTOR) positiveCorrelation p(HGNC:MAPT, pmod(Ph)) + bp(MESH:"Neuronal Outgrowth") association p(HGNC:APP) - - - pmid:30985105 + pubmed:23383175 - act(p(HGNC:MTOR)) decreases p(HGNC:SNCA) + act(a(GO:axon)) decreases path(MESH:Paralysis) - pmid:30061532 + pubmed:23383175 - path(MESH:"Lewy Body Disease") association p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + act(a(GO:axon)) decreases path(HP:"Limb muscle weakness") - pmid:30061532 + pubmed:27807169 - path(MESH:"Lewy Body Disease") association a(CHEBI:"amyloid-beta") + a(GO:axon) positiveCorrelation p(RGD:Cdk5r2) - pmid:17009926 + pubmed:28745240 - path(MESH:"Lewy Body Disease") negativeCorrelation act(p(FPLX:CHRN)) + act(p(HGNC:SRC)) increases p(HGNC:NFKBIA, pmod(go:0006468 ! "protein phosphorylation", Tyr, 42)) - pmid:17009926 + pubmed:29661268 - path(MESH:"Lewy Body Disease") negativeCorrelation p(FPLX:CHRN) + act(p(HGNC:SRC), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:27075649 + pubmed:19293145 - path(MESH:"Lewy Body Disease") positiveCorrelation a(HBP:HBP00016) + p(HGNC:SRC) increases bp(MESH:Neuroprotection) - pmid:29980653 + pubmed:24653673 - path(MESH:"Lewy Body Disease") isA path(MESH:"Neurodegenerative Diseases") + p(HGNC:SRC) increases p(HGNC:PPP2CA, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) - pmid:24590577 + pubmed:24653673 - a(HBP:"Tau aggregates") increases path(MESH:"Neurofibrillary Tangles") + p(HGNC:SRC) increases p(HGNC:PPP2CA, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) - pmid:24027553 + pubmed:24653673 - a(HBP:"Tau aggregates") increases path(MESH:"Neurofibrillary Tangles") + p(HGNC:SRC) increases p(HGNC:PPP2CB, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) - pmid:28083634 + pubmed:24653673 - a(HBP:"Tau aggregates") negativeCorrelation p(HGNC:OTUB1) + p(HGNC:SRC) increases p(HGNC:PPP2CB, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) - pmid:29758300 + pubmed:29191965 - a(HBP:"Tau aggregates") association bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + p(HGNC:SRC) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr)) - pmid:23528736 + pubmed:26751493 - a(HBP:"Tau aggregates") association bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + p(HGNC:SRC) association p(CONSO:"projection domain") + + + + - pmid:29758300 + pubmed:18467332 - a(HBP:"Tau aggregates") association bp(GO:autophagy) + p(HGNC:SRC) isA complex(p(HGNC:MAPT), p(HGNC:SRC)) + + - pmid:29758300 + pubmed:28745240 - a(HBP:"Tau aggregates") association complex(a(MESH:"Lipid Bilayers"), p(HGNC:MAPT)) + p(HGNC:NFKBIA, pmod(go:0006468 ! "protein phosphorylation", Tyr, 42)) increases act(complex(GO:"NF-kappaB complex")) - pmid:22908190 + pubmed:27288790 - a(HBP:"Tau aggregates") increases p(HBP:"Tau aggregates", pmod(Ub)) + p(HGNC:NFKBIA, pmod(go:0006468 ! "protein phosphorylation", Tyr, 42)) increases act(p(FPLX:NFkappaB)) + + + + - pmid:22908190 + pubmed:29179999 - a(HBP:"Tau aggregates") decreases act(complex(GO:"proteasome complex")) + p(HGNC:NFKBIA) decreases act(p(FPLX:NFkappaB, loc(MESH:Cytosol))) - pmid:30116051 + pubmed:27288790 - a(HBP:"Tau aggregates") decreases act(complex(GO:"proteasome complex")) + p(HGNC:NFKBIA) decreases act(p(FPLX:NFkappaB, loc(MESH:Cytosol))) - pmid:30116051 + pubmed:26551702 - a(HBP:"Tau aggregates") decreases deg(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) + p(HGNC:NFKBIA) decreases act(p(FPLX:NFkappaB)) - pmid:30116051 + pubmed:26551702 - a(HBP:"Tau aggregates") decreases deg(a(HBP:"Tau oligomers")) + deg(p(HGNC:NFKBIA)) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) - - - pmid:30116051 - - a(HBP:"Tau aggregates") decreases bp(GO:"chaperone-mediated autophagy") - + - pmid:24027553 + pubmed:28745240 - a(HBP:"Tau aggregates") positiveCorrelation path(HBP:neurotoxicity) + act(p(HGNC:LCK)) increases p(HGNC:NFKBIA, pmod(go:0006468 ! "protein phosphorylation", Tyr, 42)) - pmid:24027553 + pubmed:30640040 - a(HBP:"Tau aggregates") decreases act(p(HGNCGENEFAMILY:Proteasome)) + p(HGNC:LCK) association a(PUBCHEM:4878) - pmid:24027553 + pubmed:29191965 - a(HBP:"Tau aggregates") positiveCorrelation a(MESH:Autophagosomes) + p(HGNC:LCK) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr)) - pmid:24027553 + pubmed:26751493 - a(HBP:"Tau aggregates") positiveCorrelation p(HGNC:MAPT, frag("561_685")) + p(HGNC:LCK) association p(CONSO:"projection domain") - pmid:27574109 + pubmed:26631930 - a(HBP:"Tau aggregates") decreases bp(GO:"anterograde axonal transport") + p(HGNC:LCK) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) + + - pmid:29590627 + pubmed:10887109 - a(HBP:"Tau aggregates") increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + act(p(HGNC:LCK), ma(go:0016301 ! "kinase activity")) increases p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation")) + + - pmid:29590627 + pubmed:10887109 - a(HBP:"Tau aggregates") increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) + act(p(HGNC:LCK), ma(go:0016301 ! "kinase activity")) increases p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr)) - pmid:29590627 + pubmed:10887109 - a(HBP:"Tau aggregates") increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + act(p(HGNC:LCK), ma(go:0016301 ! "kinase activity")) increases p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr), var("p.Tyr358Phe")) - pmid:29590627 + pubmed:10887109 - a(HBP:"Tau aggregates") increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) + act(p(HGNC:LCK), ma(go:0016301 ! "kinase activity")) causesNoChange p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr), var("p.Tyr340Phe")) - pmid:29590627 + pubmed:10887109 - a(HBP:"Tau aggregates") increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) + act(p(HGNC:LCK), ma(go:0016301 ! "kinase activity")) causesNoChange p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr), var("p.Tyr340Phe"), var("p.Tyr358Phe")) - pmid:26751493 + pubmed:10887109 - a(HBP:"Tau aggregates") positiveCorrelation tloc(a(HBP:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) + act(p(HGNC:LCK), ma(go:0016301 ! "kinase activity")) increases p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 340)) - pmid:26751493 + pubmed:10887109 - tloc(a(HBP:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) positiveCorrelation a(HBP:"Tau aggregates") + act(p(HGNC:LCK), ma(go:0016301 ! "kinase activity")) increases p(HGNC:PECAM1, pmod(go:0006468 ! "protein phosphorylation", Tyr, 686)) - pmid:29590627 + pubmed:28745240 - a(HBP:"Tau aggregates") association a(GO:"early endosome") + p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation", Ser, 536)) negativeCorrelation bp(MESH:"Neuronal Outgrowth") - pmid:29590627 + pubmed:28745240 - a(HBP:"Tau aggregates") association a(GO:"late endosome") + bp(GO:"axon guidance") increases bp(GO:neurogenesis) - pmid:29590627 + pubmed:28745240 - a(HBP:"Tau aggregates") association a(GO:lysosome) + bp(GO:"axon guidance") increases a(GO:axon) - pmid:22611162 + pubmed:21861815 - a(HBP:"Tau aggregates") increases path(HBP:proteotoxicity) + bp(GO:"axon guidance") association p(HGNC:NRP1) - pmid:22611162 + pubmed:28745240 - a(HBP:"Tau aggregates") decreases bp(GO:"axonal transport") + p(HGNC:ITGB1) increases bp(GO:"axon guidance") - pmid:26631930 + pubmed:28745240 - a(HBP:"Tau aggregates") decreases bp(GO:"axonal transport") + p(HGNC:ITGB1) increases a(GO:axon) + + + + - pmid:22611162 + pubmed:21214928 - a(HBP:"Tau aggregates") decreases bp(GO:"synaptic signaling") + p(HGNC:ITGB1) association p(HGNC:APP) - pmid:22611162 + pubmed:28745240 - a(HBP:"Tau aggregates") decreases bp(GO:"synaptic signaling") + p(HGNC:NCAM1) increases a(GO:axon) - pmid:22611162 + pubmed:28745240 - a(HBP:"Tau aggregates") decreases bp(GO:"maintenance of synapse structure") + p(HGNC:SLITRK1) increases a(GO:axon) - pmid:22611162 + pubmed:28745240 - a(HBP:"Tau aggregates") decreases p(UNIPROT:O02495) + p(HGNC:GFRA1) increases a(GO:axon) - pmid:22611162 + pubmed:28745240 - a(HBP:"Tau aggregates") decreases bp(GO:"intracellular distribution of mitochondria") + p(HGNC:TIAM1) increases a(GO:axon) + + - pmid:22611162 + pubmed:22020111 - a(HBP:"Tau aggregates") decreases bp(GO:"axonal transport of mitochondrion") + act(a(MESH:"Dendritic Cells")) increases bp(GO:"T cell activation") - pmid:28528849 + pubmed:28745240 - a(HBP:"Tau aggregates") causesNoChange bp(GO:"cell death") + p(HGNC:HES1) regulates a(GO:"dendritic branch") - pmid:26458742 + pubmed:28745240 - a(HBP:"Tau aggregates") causesNoChange bp(GO:"cell death") + p(HGNC:HES1) regulates a(MESH:"Dendritic Cells") - pmid:28528849 + pubmed:28745240 - a(HBP:"Tau aggregates") causesNoChange a(GO:membrane) + p(HGNC:HES5) regulates a(GO:"dendritic branch") - pmid:29988016 + pubmed:28745240 - a(HBP:"Tau aggregates") negativeCorrelation a(CHEBI:heparin) + p(HGNC:HES5) regulates a(MESH:"Dendritic Cells") - pmid:29988016 + pubmed:28745240 - a(HBP:"Tau aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAP1B) increases a(MESH:"Dendritic Cells") - pmid:27373205 + pubmed:28745240 - a(HBP:"Tau aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAP2) increases a(MESH:"Dendritic Cells") - pmid:26631930 + pubmed:30061532 - a(HBP:"Tau aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAP2) increases a(GO:microtubule) - pmid:22817713 + pubmed:30061532 - a(HBP:"Tau aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAP2) increases bp(GO:"dendritic spine organization") - pmid:21882945 + pubmed:30061532 - a(HBP:"Tau aggregates") increases path(MESH:Tauopathies) + p(HGNC:MAP2) increases bp(GO:"cytoskeleton organization") + + + + - pmid:29311797 + pubmed:28669544 - a(HBP:"Tau aggregates") increases path(MESH:Tauopathies) + p(HGNC:MAP2) causesNoChange p(HGNC:DLG4) - pmid:30640040 + pubmed:30988501 - a(HBP:"Tau aggregates") increases bp(GO:"cell killing") + p(HGNC:C3) increases bp(GO:"complement-mediated synapse pruning") - pmid:29191965 + pubmed:30988501 - a(HBP:"Tau aggregates") decreases act(a(GO:synapse)) + p(HGNC:C4A) positiveCorrelation path(DOID:schizophrenia) - pmid:29191965 + pubmed:28745240 - a(HBP:"Tau aggregates") decreases a(GO:presynapse) + complex(a(GO:"membrane attack complex"), p(HGNC:C5)) increases act(complex(GO:"NF-kappaB complex")) + + + + - pmid:29191965 + pubmed:28745240 - a(HBP:"Tau aggregates") positiveCorrelation p(HGNC:MAPT, pmod(Ph)) + p(HGNC:IL1B) increases bp(GO:"neuron death") - pmid:30985105 + pubmed:27288790 - a(HBP:"Tau aggregates") association p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation", Ser, 400)) + p(HGNC:IL1B) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:25374103 + pubmed:25652642 - a(HBP:"Tau aggregates") increases a(GO:"neurofibrillary tangle") + p(HGNC:IL1B) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:28420982 + pubmed:24561250 - a(HBP:"Tau aggregates") increases a(GO:"neurofibrillary tangle") + p(HGNC:IL1B) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:29844403 + pubmed:27314526 - a(HBP:"Tau aggregates") positiveCorrelation a(GO:"neurofibrillary tangle") + p(HGNC:IL1B) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:28877763 + pubmed:27288790 - a(HBP:"Tau aggregates") association p(MGI:Syk, pmod(Ph, Tyr, 525)) + p(HGNC:IL1B) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) - pmid:28877763 + pubmed:26551702 - a(HBP:"Tau aggregates") association p(MGI:Syk, pmod(Ph, Tyr, 526)) + p(HGNC:IL1B) increases act(p(FPLX:NFkappaB)) - pmid:28877763 + pubmed:27288790 - a(HBP:"Tau aggregates") association p(HGNC:SYK, pmod(Ph)) + p(HGNC:IL1B) increases p(FPLX:"IKK_complex", pmod(go:0006468 ! "protein phosphorylation")) - pmid:28877763 + pubmed:27288790 - a(HBP:"Tau aggregates") positiveCorrelation p(HGNC:SYK, pmod(Ph)) + p(HGNC:IL1B) increases p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation")) - pmid:28420982 + pubmed:27288790 - a(HBP:"Tau aggregates") decreases bp(GO:"anterograde axonal protein transport") + p(HGNC:IL1B) decreases p(FPLX:IKB) - pmid:27373205 + pubmed:27288790 - a(HBP:"Tau aggregates") decreases bp(GO:"anterograde axonal protein transport") + p(HGNC:IL1B) increases a(MESH:Cytokines) - pmid:22817713 + pubmed:27288790 - a(HBP:"Tau aggregates") decreases bp(GO:"anterograde axonal protein transport") + p(HGNC:IL1B) increases a(MESH:Chemokines) - pmid:22817713 + pubmed:30962309 - a(HBP:"Tau aggregates") decreases bp(GO:"anterograde axonal protein transport") + p(HGNC:IL1B) association path(DOID:cancer) - pmid:22817713 + pubmed:30962309 - a(HBP:"Tau aggregates") decreases bp(GO:"anterograde axonal protein transport") + p(HGNC:IL1B) association path(DOID:"multiple sclerosis") - pmid:28420982 + pubmed:30967783 - a(HBP:"Tau aggregates") association bp(MESH:"Neuronal Plasticity") + p(HGNC:IL1B) increases path(DOID:"multiple sclerosis") - pmid:28420982 + pubmed:30962309 - a(HBP:"Tau aggregates") association sec(p(HGNC:MAPT)) + p(HGNC:IL1B) association path(DOID:"rheumatic disease") - pmid:28420982 + pubmed:30962309 - a(HBP:"Tau aggregates") association a(CHEBI:dextran) + act(p(HGNC:IL1B)) increases path(DOID:"neurodegenerative disease") - pmid:29311797 + pubmed:26445701 - a(HBP:"Tau aggregates") association p(HGNC:HDAC6) + p(HGNC:IL1B) increases path(HP:"CNS demyelination") - pmid:29311797 + pubmed:26445701 - a(HBP:"Tau aggregates") association bp(GO:"glucocorticoid receptor signaling pathway") + p(HGNC:IL1B) increases path(MESH:"Diffuse Axonal Injury") - pmid:26458742 + pubmed:26445701 - a(HBP:"Tau aggregates") increases tloc(p(MGI:Mapt), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:Neurons)) + p(HGNC:IL1B) increases bp(GO:"positive regulation of oligodendrocyte apoptotic process") - pmid:27373205 + pubmed:30967783 - a(HBP:"Tau aggregates") causesNoChange bp(GO:"retrograde axonal protein transport") + p(HGNC:IL1B) increases bp(GO:"inflammatory response") - pmid:26631930 + pubmed:24561250 - a(HBP:"Tau aggregates") negativeCorrelation complex(a(GO:microtubule), p(HGNC:MAPT)) + p(HGNC:IL1B) increases bp(GO:"inflammatory response") - pmid:26631930 + pubmed:30967783 - a(HBP:"Tau aggregates") positiveCorrelation bp(GO:aging) + p(HGNC:IL1B) increases path(EFO:"experimental autoimmune encephalomyelitis") - pmid:26631930 + pubmed:30967783 - a(HBP:"Tau aggregates") decreases bp(GO:"microtubule polymerization") + p(HGNC:IL1B) increases path(EFO:"experimental autoimmune encephalomyelitis") - pmid:26631930 + pubmed:30967783 - a(HBP:"Tau aggregates") decreases act(a(MESH:Neurons)) + p(HGNC:IL1B) positiveCorrelation bp(GO:"T-helper 17 cell chemotaxis") - pmid:26631930 + pubmed:23092889 - a(HBP:"Tau aggregates") increases path(HBP:Neurodegeneration) + p(HGNC:IL1B) increases bp(GO:pyroptosis) - pmid:22817713 + pubmed:23702978 - a(HBP:"Tau aggregates") increases act(p(HGNC:PPP1CA)) + act(p(HGNC:IL1B)) increases bp(GO:"neutrophil activation") - pmid:22817713 + pubmed:24561250 - a(HBP:"Tau aggregates") increases act(p(HGNC:GSK3A)) + p(HGNC:IL1B) positiveCorrelation complex(GO:"inflammasome complex") - pmid:22817713 + pubmed:27314526 - a(HBP:"Tau aggregates") association p(HGNC:MAPT, pmod(Ph, Ser, 202)) + p(HGNC:IL1B) positiveCorrelation path(MESH:Dementia) - pmid:22817713 + pubmed:27314526 - a(HBP:"Tau aggregates") association p(HGNC:MAPT, pmod(Ph, Thr, 205)) + p(HGNC:IL1B) increases bp(GO:"microglial cell activation") - - - pmid:23531502 + pubmed:27314526 - a(HBP:"Tau aggregates") association act(p(HGNC:GSK3B)) + p(HGNC:IL1B) increases bp(GO:"astrocyte activation") - pmid:23531502 + pubmed:27314526 - a(HBP:"Tau aggregates") association act(p(HGNC:MAPK14)) + tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) increases p(HGNC:APP) - pmid:26400044 + pubmed:27314526 - a(HBP:"Tau aggregates") increases complex(p(HBP:"Tau aggregates"), p(MGI:Dpysl2, pmod(Ph)), p(MGI:Wasf1, pmod(Ph))) + tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) increases a(CHEBI:amyloid-beta) - pmid:28877763 + pubmed:30988501 - a(HBP:"Tau aggregates") increases act(p(HGNC:SYK)) + p(HGNC:IL1B) increases a(MESH:"Neural Pathways") - - - pmid:30061532 + pubmed:30988501 - p(HGNC:TARDBP, loc(GO:"inclusion body")) association path(MESH:"Frontotemporal Lobar Degeneration") + p(HGNC:IL1B) increases act(a(MESH:Microglia)) - pmid:30061532 + pubmed:30988501 - p(HGNC:TARDBP, loc(HBP:"dystrophic neurite")) association path(MESH:"Frontotemporal Lobar Degeneration") + p(HGNC:IL1B) negativeCorrelation path(DOID:schizophrenia) - - - - - - - pmid:29980653 + pubmed:30988501 - p(HGNC:TARDBP) positiveCorrelation path(MESH:"Frontotemporal Dementia") + p(HGNC:IL1B) negativeCorrelation path(DOID:"mental depression") - pmid:29980653 + pubmed:30988501 - p(HGNC:TARDBP) positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") + p(HGNC:IL1B) negativeCorrelation path(DOID:"post-traumatic stress disorder") - pmid:29334120 + pubmed:28745240 - act(p(HGNC:TARDBP)) increases p(HBP:"4R tau") + bp(GO:"p38MAPK cascade") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) - - - - - + + + pubmed:25514383 + + bp(GO:"p38MAPK cascade") increases a(CONSO:"Tau aggregates") + - + + + pubmed:27314526 + + bp(GO:"p38MAPK cascade") increases complex(GO:"neurofibrillary tangle") + - pmid:27181519 + pubmed:30145931 - p(HGNC:TARDBP) regulates bp(GO:autophagy) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) positiveCorrelation a(CONSO:"amyloid-beta oligomers") - pmid:27181519 + pubmed:28784767 - p(HGNC:TARDBP) regulates a(GO:lysosome) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) increases a(CONSO:"Tau Protein Secondary Structure, Turn") - pmid:26702100 + pubmed:21882945 - p(HGNC:TARDBP) decreases a(GO:lysosome) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27181519 + pubmed:28745240 - p(HGNC:TARDBP) regulates bp(GO:"autophagosome assembly") + act(complex(p(HGNC:CDK5), p(HGNC:CDK5R1))) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) - pmid:26702100 + pubmed:26118667 - p(HGNC:TARDBP) decreases bp(GO:"autophagosome assembly") + complex(p(HGNC:CDK5), p(HGNC:CDK5R1)) increases act(p(HGNC:CDK5)) + + + pubmed:26118667 + + p(HGNC:CDK5) increases complex(p(HGNC:CDK5), p(HGNC:CDK5R1)) + + - pmid:27181519 + pubmed:29661268 - act(p(HGNC:TARDBP)) negativeCorrelation path(MESH:"Motor Neuron Disease") + act(p(HGNC:CDK5), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:27181519 + pubmed:19419557 - p(HGNC:TARDBP) regulates bp(MESH:"Transcription, Genetic") + act(p(HGNC:CDK5), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:27181519 + pubmed:12428809 - p(HGNC:TARDBP) association bp(GO:"RNA splicing") + p(HGNC:CDK5) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:27181519 + pubmed:29758300 - p(HGNC:TARDBP, loc(GO:cytosol)) association complex(GO:"cytoplasmic stress granule") + p(HGNC:CDK5) regulates p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:27181519 + pubmed:8282104 - act(p(HGNC:TARDBP)) regulates a(CHEBI:"nucleic acid") + p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + pubmed:21882945 + + act(p(HGNC:CDK5)) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + - pmid:27181519 + pubmed:29191965 - p(HGNC:TARDBP) decreases bp(GO:"motor behavior") + p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:27181519 + pubmed:27314526 - p(HGNC:TARDBP) decreases bp(GO:locomotion) + p(HGNC:CDK5) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:26702100 + pubmed:30444369 - p(HGNC:TARDBP) decreases p(HGNC:TFEB, loc(GO:nucleus)) + p(HGNC:CDK5) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:26702100 + pubmed:24653673 - p(HGNC:TARDBP) increases p(HGNC:TFEB, loc(GO:cytoplasm)) + p(HGNC:CDK5) association path(MESH:"Alzheimer Disease") - pmid:26702100 + pubmed:8282104 - p(HGNC:TARDBP) decreases p(HGNC:TFEB, loc(GO:nucleus)) + p(HGNC:CDK5) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:26702100 + pubmed:30444369 - p(HGNC:TARDBP) increases p(HGNC:TFEB, loc(GO:cytoplasm)) + p(HGNC:CDK5) increases p(HGNC:PRDX2, pmod(go:0006468 ! "protein phosphorylation", Thr, 89)) - pmid:26702100 + pubmed:22122372 - p(HGNC:TARDBP) decreases p(HGNC:TFEB, loc(GO:lysosome)) + p(HGNC:CDK5) increases p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Thr, 654)) - pmid:26702100 + pubmed:22122372 - p(HGNC:TARDBP) increases p(HGNC:MTOR) + p(HGNC:CDK5) increases p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Thr, 668)) - pmid:26702100 + pubmed:22122372 - p(HGNC:TARDBP) increases p(HGNC:MTOR) + p(HGNC:CDK5) increases p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Ser, 665)) - pmid:26702100 + pubmed:30061532 - p(HGNC:TARDBP) regulates p(HGNC:MTOR) + p(HGNC:CDK5) regulates p(HGNC:DPYSL2) - pmid:26702100 + pubmed:30061532 - p(HGNC:TARDBP) increases act(p(HGNCGENEFAMILY:"MTOR complex 1")) + p(HGNC:CDK5) positiveCorrelation a(GO:"dendritic spine") - pmid:26702100 + pubmed:30061532 - p(HGNC:TARDBP) increases act(p(HGNCGENEFAMILY:"MTOR complex 1")) + p(HGNC:CDK5) positiveCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:26702100 + pubmed:25001178 - act(p(HGNC:TARDBP)) association p(HGNCGENEFAMILY:"MTOR complex 1") + act(p(HGNC:CDK5), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:26702100 + pubmed:30061532 - p(HGNC:TARDBP) increases p(HGNC:RPTOR) + act(p(HGNC:CDK5)) positiveCorrelation path(MESH:Schizophrenia) - pmid:26702100 + pubmed:30061532 - p(HGNC:TARDBP) increases p(HGNC:RPTOR) + act(p(HGNC:CDK5)) negativeCorrelation p(HGNC:CDK5R1) + + - pmid:26702100 + pubmed:30515821 - p(HGNC:TARDBP) regulates p(HGNC:RPTOR) + act(p(HGNC:CDK5)) increases p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 579)) - pmid:26702100 + pubmed:30515821 - p(HGNC:TARDBP) increases p(HGNC:RPTOR) + p(HGNC:CDK5) increases p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 585)) - pmid:26702100 + pubmed:30515821 - p(HGNC:TARDBP) increases r(HGNC:RPTOR) + p(HGNC:CDK5) increases p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 616)) - pmid:26702100 + pubmed:30515821 - p(HGNC:TARDBP) increases r(HGNC:RPTOR) + act(p(HGNC:CDK5)) association path(MESH:"Wounds and Injuries") - pmid:26702100 + pubmed:30515821 - p(HGNC:TARDBP) increases act(r(HGNC:RPTOR)) + act(p(HGNC:CDK5)) increases bp(GO:"programmed cell death") + + - pmid:26702100 + pubmed:24653673 - p(HGNC:TARDBP) causesNoChange p(HGNC:TFEB, var("p.1_30del"), loc(GO:lysosome)) + act(p(HGNC:CDK5)) negativeCorrelation a(GO:"microtubule cytoskeleton") - pmid:26702100 + pubmed:24653673 - p(HGNC:TARDBP) causesNoChange p(HGNC:TFEB, var("p.Gln10Ala"), var("p.Lys11Ala"), loc(GO:lysosome)) + act(p(HGNC:CDK5)) negativeCorrelation a(GO:"neurofilament cytoskeleton") - pmid:26702100 + pubmed:24653673 - p(HGNC:TARDBP) decreases p(HGNC:LAMP1) + act(p(HGNC:CDK5)) negativeCorrelation p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation")) - pmid:26702100 + pubmed:24653673 - p(HGNC:TARDBP) decreases r(HGNC:LAMP1) + act(p(HGNC:CDK5)) negativeCorrelation bp(CONSO:"APP processing") - pmid:26702100 + pubmed:24653673 - p(HGNC:TARDBP) decreases p(HGNCGENEFAMILY:Cathepsins) + act(p(HGNC:CDK5)) negativeCorrelation bp(GO:neurogenesis) - pmid:26702100 + pubmed:24653673 - p(HGNC:TARDBP) decreases a(MESH:"Vacuolar Proton-Translocating ATPases") + act(p(HGNC:CDK5)) positiveCorrelation bp(GO:"negative regulation of synaptic plasticity") - pmid:26702100 + pubmed:24653673 - p(HGNC:TARDBP) decreases p(HGNC:ATG5) + act(p(HGNC:CDK5)) positiveCorrelation bp(GO:"apoptotic process") - pmid:26702100 + pubmed:8282104 - p(HGNC:TARDBP) decreases r(HGNC:ATG5) + p(HGNC:CDK5) directlyIncreases p(CONSO:CONSO00053, pmod(go:0006468 ! "protein phosphorylation")) + + - pmid:26702100 + pubmed:8282104 - p(HGNC:TARDBP) decreases p(HGNC:BECN1) + p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) - pmid:26702100 + pubmed:17078951 - p(HGNC:TARDBP) decreases r(HGNC:BECN1) + act(p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) - pmid:26702100 + pubmed:8282104 - p(HGNC:TARDBP) decreases p(HGNC:ATG9B) + p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) - pmid:26702100 + pubmed:8282104 - p(HGNC:TARDBP) decreases r(HGNC:ATG9B) + p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 235)) - pmid:26702100 + pubmed:8282104 - p(HGNC:TARDBP) decreases a(GO:autophagosome) + p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) - pmid:26702100 + pubmed:8282104 - p(HGNC:TARDBP) decreases a(GO:autophagosome) + p(HGNC:CDK5) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) - pmid:26702100 + pubmed:8282104 - p(HGNC:TARDBP) decreases p(HGNC:SQSTM1) + p(HGNC:CDK5) association a(GO:microtubule) - pmid:26702100 + pubmed:8282104 - p(HGNC:TARDBP) decreases p(HGNC:SQSTM1) + p(HGNC:CDK5) association a(CONSO:CONSO00006) - pmid:26702100 + pubmed:8282104 - p(HGNC:TARDBP) decreases p(HGNC:MAP1LC3A) + p(HGNC:CDK5) increases rxn(reactants(p(HGNC:MAPT)), products(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")))) - pmid:26702100 + pubmed:21882945 - p(HGNC:TARDBP) decreases p(HGNC:MAP1LC3B) + p(HGNC:CDK5) increases act(p(HGNC:MARK2)) + + - pmid:26702100 + pubmed:21367866 - p(HGNC:TARDBP) regulates a(GO:autolysosome) + act(p(HGNC:CDK5), ma(go:0016301 ! "kinase activity")) negativeCorrelation p(HGNC:CDC37) - pmid:26702100 + pubmed:27796283 - p(HGNC:TARDBP) regulates a(GO:autolysosome) + p(HGNC:CDK5) increases p(HGNC:CAMKV, pmod(go:0006468 ! "protein phosphorylation", Thr, 345)) - pmid:26702100 + pubmed:17078951 - p(HGNC:TARDBP) increases bp(GO:"autophagosome-lysosome fusion") + act(p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 181)) - pmid:26702100 + pubmed:17078951 - p(HGNC:TARDBP) increases bp(GO:"autophagosome-lysosome fusion") + act(p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) - pmid:26702100 + pubmed:17078951 - p(HGNC:TARDBP) increases g(HGNC:DCTN1) + act(p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) - pmid:26702100 + pubmed:17078951 - p(HGNC:TARDBP) increases p(HGNC:DCTN1) + act(p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) - pmid:26702100 + pubmed:8702879 - p(HGNC:TARDBP) causesNoChange a(MESH:Dyneins) + act(p(HGNC:CDK5)) increases p(HGNC:SYN1, pmod(go:0006468 ! "protein phosphorylation", Ser, 551)) - pmid:26702100 + pubmed:8702879 - p(HGNC:TARDBP) increases p(HGNC:EIF4EBP1, pmod(Ph)) + act(p(HGNC:CDK5)) increases p(HGNC:SYN1, pmod(go:0006468 ! "protein phosphorylation", Ser, 553)) + + - pmid:26702100 + pubmed:26118667 - p(HGNC:TARDBP) increases p(HGNC:RPS6KB1, pmod(Ph)) + p(HGNC:CDK5R1) partOf complex(p(HGNC:CDK5), p(HGNC:CDK5R1)) + + - pmid:26702100 + pubmed:30061532 - p(HGNC:TARDBP) decreases g(HGNC:ATP6V1H) + p(HGNC:CDK5R1) negativeCorrelation path(MESH:Schizophrenia) - pmid:26702100 + pubmed:30061532 - p(HGNC:TARDBP) decreases g(HGNC:CTSB) + p(HGNC:CDK5R1) negativeCorrelation act(p(HGNC:CDK5)) - pmid:26702100 + pubmed:26118667 - p(HGNC:TARDBP) decreases g(HGNC:CTSD) + p(HGNC:CDK5R1) increases bp(GO:"neuron maturation") - pmid:26702100 + pubmed:26118667 - p(HGNC:TARDBP) decreases g(HGNC:LAMP1) + p(HGNC:CDK5R1) negativeCorrelation p(CONSO:"CDK5R1 p25") + + - pmid:26702100 + pubmed:19126755 - p(HGNC:TARDBP) decreases g(HGNC:PSAP) + path(CONSO:neurotoxicity) association a(CHEBI:nicotine) - pmid:26702100 + pubmed:19293145 - p(HGNC:TARDBP) decreases g(HGNC:SGSH) + path(CONSO:neurotoxicity) association a(CONSO:"amyloid-beta oligomers") - pmid:26702100 + pubmed:19293145 - p(HGNC:TARDBP) decreases g(HGNC:BECN1) + path(CONSO:neurotoxicity) association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:30061532 + pubmed:22908190 - a(CHEBI:"mTOR inhibitor") decreases act(p(HGNC:MTOR)) + path(CONSO:neurotoxicity) positiveCorrelation a(CHEBI:"amyloid-beta polypeptide 42") - pmid:30061532 + pubmed:24027553 - a(CHEBI:"mTOR inhibitor") decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + path(CONSO:neurotoxicity) positiveCorrelation a(CONSO:"Tau aggregates") - pmid:30061532 + pubmed:29686391 - a(CHEBI:"mTOR inhibitor") decreases p(HGNC:SNCA, pmod(HBP:misfolded)) + path(CONSO:neurotoxicity) positiveCorrelation a(CONSO:"Tau oligomers") - pmid:30061532 + pubmed:26671985 - a(CHEBI:"mTOR inhibitor") decreases p(HGNC:TARDBP, pmod(HBP:misfolded)) + path(CONSO:neurotoxicity) positiveCorrelation a(CONSO:"Tau oligomers") - pmid:30061532 + pubmed:26671985 - path(HBP:Neurodegeneration) association act(a(GO:synapse)) + path(CONSO:neurotoxicity) negativeCorrelation act(complex(GO:axon)) - pmid:19126755 + pubmed:26671985 - path(HBP:Neurodegeneration) increases bp(GO:cognition) + path(CONSO:neurotoxicity) association p(HGNC:MAPT, var("p.Asp421*")) - pmid:19126755 + pubmed:25652642 - path(HBP:Neurodegeneration) negativeCorrelation p(MGI:Chrnb2) + bp(CONSO:"APP processing") positiveCorrelation act(complex(GO:"NF-kappaB complex")) - pmid:30106381 + pubmed:25652642 - path(HBP:Neurodegeneration) association p(HGNC:WFS1) + bp(CONSO:"APP processing") increases a(CHEBI:amyloid-beta) - pmid:21722302 + pubmed:27094130 - path(HBP:Neurodegeneration) association path(MESH:"Alzheimer Disease") + bp(CONSO:"APP processing") increases a(CHEBI:amyloid-beta) - pmid:21722302 + pubmed:24653673 - path(HBP:Neurodegeneration) association path(MESH:"Parkinson Disease") + bp(CONSO:"APP processing") negativeCorrelation act(p(HGNC:GSK3B)) - pmid:21722302 + pubmed:24653673 - path(HBP:Neurodegeneration) association path(MESH:"Amyotrophic Lateral Sclerosis") + bp(CONSO:"APP processing") negativeCorrelation act(p(HGNC:CDK5)) - pmid:21722302 + pubmed:24653673 - path(HBP:Neurodegeneration) association path(MESH:"Amyotrophic Lateral Sclerosis") + bp(CONSO:"APP processing") negativeCorrelation act(p(FPLX:ERK)) - pmid:21722302 + pubmed:30116051 - path(HBP:Neurodegeneration) association path(MESH:"Prion Diseases") + bp(CONSO:"APP processing") association p(HGNC:LRRK2, var("?")) - pmid:21722302 + pubmed:24027553 - path(HBP:Neurodegeneration) association a(HBP:"amyloid-beta aggregates") + bp(CONSO:"APP processing") association p(HGNC:HTRA1) - pmid:29758300 + pubmed:24027553 - path(HBP:Neurodegeneration) negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + bp(CONSO:"APP processing") association path(MESH:"Alzheimer Disease") - pmid:18930136 + pubmed:27094130 - path(HBP:Neurodegeneration) negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + bp(CONSO:"APP processing") association p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation", Thr, 668)) - pmid:18930136 + pubmed:28745240 - path(HBP:Neurodegeneration) negativeCorrelation bp(GO:"cellular protein catabolic process") + complex(p(HGNC:BACE1), p(HGNC:NFKB1), p(HGNC:RELA)) increases p(HGNC:BACE1) - pmid:17403556 + pubmed:28745240 - path(HBP:Neurodegeneration) positiveCorrelation p(HGNC:MAPT, pmod(Ph)) + complex(p(HGNC:NFKB2), p(HGNC:RELA)) increases complex(p(HGNC:BACE1), p(HGNC:NFKB2), p(HGNC:RELA)) + + + + + + + + - pmid:26631930 + pubmed:28745240 - path(HBP:Neurodegeneration) association tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) + complex(p(HGNC:BACE1), p(HGNC:NFKB2), p(HGNC:RELA)) increases p(HGNC:BACE1) - pmid:19251756 + pubmed:28745240 - path(HBP:Neurodegeneration) negativeCorrelation act(p(INTERPRO:"Triosephosphate isomerase")) + complex(p(HGNC:BACE1), p(HGNC:NFKB2), p(HGNC:RELA)) decreases p(HGNC:BACE1) - pmid:22952452 + pubmed:28745240 - path(HBP:Neurodegeneration) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) + complex(p(HGNC:NFKB2), p(HGNC:REL)) increases complex(p(HGNC:BACE1), p(HGNC:NFKB2), p(HGNC:REL)) - pmid:27181519 + pubmed:28745240 - path(HBP:Neurodegeneration) association p(HGNC:TBK1) + p(HGNC:SOD2) decreases bp(MESH:"Oxidative Stress") - pmid:30061532 + pubmed:28745240 - a(CHEBI:methamphetamine) decreases bp(GO:"dopamine secretion, neurotransmission") + p(HGNC:SOD2) decreases bp(GO:"apoptotic process") - pmid:30061532 + pubmed:25652642 - a(CHEBI:methamphetamine) association bp(GO:"dopamine secretion, neurotransmission") + act(p(HGNC:SOD2)) decreases act(a(CHEBI:amyloid-beta)) - pmid:30061532 + pubmed:30962309 - a(CHEBI:methamphetamine) decreases act(p(HGNCGENEFAMILY:"Dopamine receptors")) + p(HGNC:SOD2) decreases a(CHEBI:"reactive oxygen species") - pmid:30061532 + pubmed:24563850 - a(CHEBI:methamphetamine) decreases act(p(HGNC:DRD1)) + p(HGNC:SOD2) increases rxn(reactants(a(CHEBI:superoxide)), products(a(CHEBI:"hydrogen peroxide"), a(CHEBI:dioxygen))) - pmid:30061532 + pubmed:28745240 - a(CHEBI:methamphetamine) association p(HGNC:DRD1) + act(complex(GO:"calcium- and calmodulin-dependent protein kinase complex")) increases act(complex(GO:"NF-kappaB complex")) - pmid:30061532 + pubmed:30515821 - a(CHEBI:methamphetamine) increases bp(GO:"non-canonical Wnt signaling pathway") + complex(GO:"calcium- and calmodulin-dependent protein kinase complex") increases bp(GO:"mitochondrial fission") - pmid:30061532 + pubmed:28745240 - a(CHEBI:methamphetamine) increases path(MESH:Hallucinations) + a(MESH:Calcineurin) increases act(complex(GO:"NF-kappaB complex")) - pmid:30061532 + pubmed:19293145 - a(CHEBI:methamphetamine) increases path(MESH:Delusions) + a(MESH:Calcineurin) association act(a(CHEBI:nicotine)) - pmid:30061532 + pubmed:19293145 - a(CHEBI:methamphetamine) decreases act(g(HGNC:DISC1)) + a(MESH:Calcineurin) association bp(MESH:Neuroprotection) + + - pmid:30061532 + pubmed:28745240 - a(CHEBI:methamphetamine) decreases act(g(HGNC:NRG1)) + p(HGNC:CXCL8) increases bp(GO:"neuron death") - pmid:30061532 + pubmed:29179999 - a(CHEBI:methamphetamine) decreases act(g(HGNC:DPYSL2)) + act(p(FPLX:ERK)) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) - pmid:30061532 + pubmed:27288790 - a(CHEBI:methamphetamine) increases path(MESH:"Psychoses, Substance-Induced") + p(FPLX:ERK) increases act(p(FPLX:NFkappaB)) + + + + - pmid:30061532 + pubmed:19293145 - a(CHEBI:methamphetamine) decreases act(p(HGNC:SLC6A3)) + p(FPLX:ERK) association a(CHEBI:nicotine) + + - pmid:30061532 + pubmed:24653673 - a(CHEBI:methamphetamine) decreases p(HGNC:SLC6A3) + act(p(FPLX:ERK)) negativeCorrelation a(GO:"microtubule cytoskeleton") - pmid:30061532 + pubmed:24653673 - a(CHEBI:methamphetamine) decreases a(CHEBI:dopamine, loc(MESH:"Nerve Endings")) + act(p(FPLX:ERK)) negativeCorrelation a(GO:"neurofilament cytoskeleton") - pmid:30061532 + pubmed:24653673 - a(CHEBI:methamphetamine) decreases sec(a(CHEBI:dopamine)) + act(p(FPLX:ERK)) negativeCorrelation p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation")) - pmid:30061532 + pubmed:24653673 - a(CHEBI:methamphetamine) increases a(CHEBI:dopamine, loc(GO:cytosol)) + act(p(FPLX:ERK)) negativeCorrelation bp(CONSO:"APP processing") - pmid:30061532 + pubmed:24653673 - a(CHEBI:methamphetamine) association sec(a(CHEBI:dopamine)) + act(p(FPLX:ERK)) negativeCorrelation bp(GO:neurogenesis) - pmid:30061532 + pubmed:24653673 - a(CHEBI:methamphetamine) decreases bp(GO:autophagy) + act(p(FPLX:ERK)) positiveCorrelation bp(GO:"negative regulation of synaptic plasticity") - pmid:30061532 + pubmed:24653673 - a(CHEBI:methamphetamine) decreases act(p(HGNC:SLC18A2)) + act(p(FPLX:ERK)) positiveCorrelation bp(GO:"apoptotic process") - pmid:30061532 + pubmed:12428809 - a(CHEBI:methamphetamine) negativeCorrelation p(HGNC:SLC18A2) + p(FPLX:ERK) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:30061532 + pubmed:8282104 - a(CHEBI:methamphetamine) increases bp(GO:"response to oxidative stress") + p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:30061532 + pubmed:8282104 - a(CHEBI:methamphetamine) increases act(p(FPLX:AKT)) + p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) - pmid:30061532 + pubmed:8282104 - a(CHEBI:methamphetamine) increases act(p(HGNC:MTOR)) + p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) - pmid:19293145 + pubmed:8282104 - act(a(CHEBI:methamphetamine)) increases bp(HBP:Neurodegeneration) + p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 235)) - pmid:30061532 + pubmed:8282104 - bp(GO:"dopamine secretion, neurotransmission") association a(CHEBI:methamphetamine) + p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) - pmid:30061532 + pubmed:8282104 - bp(GO:"dopamine secretion, neurotransmission") association bp(GO:autophagy) + p(FPLX:ERK) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) - pmid:30061532 + pubmed:8282104 - bp(GO:"dopamine secretion, neurotransmission") association p(HGNC:DISC1) + p(FPLX:ERK) association a(GO:microtubule) - pmid:30061532 + pubmed:8282104 - act(p(HGNC:DRD1)) positiveCorrelation path(MESH:Schizophrenia) + p(FPLX:ERK) association a(CONSO:CONSO00006) - pmid:30061532 + pubmed:8282104 - act(p(HGNC:DRD1)) increases act(p(HGNC:MTOR)) + p(FPLX:ERK) increases rxn(reactants(p(HGNC:MAPT)), products(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")))) - pmid:30061532 + pubmed:8282104 - act(p(HGNC:DRD1)) increases act(p(HGNC:MTOR)) + p(FPLX:ERK) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:30061532 + pubmed:27594586 - act(p(HGNC:DRD1)) decreases bp(GO:autophagy) + p(FPLX:ERK) regulates p(HGNC:MMP9) - pmid:30061532 + pubmed:24686445 - p(HGNC:DRD1) association a(CHEBI:methamphetamine) + act(p(FPLX:ERK)) increases act(p(HGNC:KAT2B)) - pmid:30061532 + pubmed:25001178 - act(p(HGNC:DRD1)) increases act(p(FPLX:AKT)) + p(FPLX:ERK) increases act(p(HGNC:CDK5), ma(go:0016301 ! "kinase activity")) - pmid:30061532 + pubmed:26551702 - act(p(HGNC:DRD1)) increases g(HGNC:CDK5) + p(FPLX:"NADPH_oxidase") increases a(CHEBI:radical) - pmid:30061532 + pubmed:24563850 - act(p(HGNC:DRD1)) increases p(HGNC:CDK5) + act(p(FPLX:"NADPH_oxidase")) increases a(CHEBI:radical) - pmid:30061532 + pubmed:24563850 - p(HGNC:DRD1) increases p(HGNC:CDK5) + act(p(FPLX:"NADPH_oxidase")) increases a(CHEBI:"reactive oxygen species") - pmid:30061532 + pubmed:27288790 - path(MESH:Hallucinations) association path(MESH:Schizophrenia) + p(HGNC:PTGS2) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:24511233 + pubmed:27288790 - path(MESH:Hallucinations) association path(MESH:Schizophrenia) + p(HGNC:PTGS2) association a(CONSO:"amyloid-beta aggregates") - pmid:24511233 + pubmed:19126755 - path(MESH:Hallucinations) biomarkerFor path(MESH:Schizophrenia) + act(p(HGNC:PTGS2)) increases a(CHEBI:"prostaglandin H2") - pmid:19721446 + pubmed:19126755 - path(MESH:Hallucinations) association path(MESH:Schizophrenia) + p(HGNC:PTGS2, loc(MESH:Neurons)) regulates path(MESH:"Neuronal Plasticity") - pmid:30061532 + pubmed:19126755 - path(MESH:Hallucinations) negativeCorrelation bp(GO:autophagy) + p(HGNC:PTGS2, loc(MESH:Neurons)) regulates bp(GO:"cell death") - pmid:30061532 + pubmed:19126755 - path(MESH:Delusions) association path(MESH:Schizophrenia) + p(HGNC:PTGS2) association p(HGNC:CHRNA4) - pmid:24511233 + pubmed:27314526 - path(MESH:Delusions) association path(MESH:Schizophrenia) + tloc(a(MESH:Interleukins), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association path(MESH:Dementia) - pmid:24511233 + pubmed:27314526 - path(MESH:Delusions) biomarkerFor path(MESH:Schizophrenia) + tloc(a(MESH:Interleukins), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association path(CONSO:neuroinflammation) - pmid:19721446 + pubmed:29179999 - path(MESH:Delusions) association path(MESH:Schizophrenia) + r(HGNC:NLRP3) association act(p(FPLX:NFkappaB)) - pmid:30061532 + pubmed:30962309 - path(MESH:Schizophrenia) association path(MESH:Hallucinations) + r(HGNC:NLRP3) negativeCorrelation m(MIRBASE:hsa-mir-223) + + - pmid:24511233 + pubmed:30962309 - path(MESH:Schizophrenia) association path(MESH:Hallucinations) + r(HGNC:NLRP3) association m(MIRBASE:hsa-mir-133b) - pmid:19721446 + pubmed:30962309 - path(MESH:Schizophrenia) association path(MESH:Hallucinations) + r(HGNC:NLRP3) negativeCorrelation path(MESH:Neuralgia) + + - pmid:30061532 + pubmed:23702978 - path(MESH:Schizophrenia) association path(MESH:Delusions) + act(p(HGNC:NOS2)) increases a(CHEBI:"nitric oxide") - pmid:24511233 + pubmed:27314526 - path(MESH:Schizophrenia) association path(MESH:Delusions) + act(p(HGNC:NOS2)) increases a(CHEBI:"nitric oxide") - pmid:19721446 + pubmed:26445701 - path(MESH:Schizophrenia) association path(MESH:Delusions) + p(HGNC:IL2) regulates path(MESH:Inflammation) - pmid:30061532 + pubmed:30988501 - path(MESH:Schizophrenia) positiveCorrelation act(p(HGNC:DRD1)) + p(HGNC:IL2) negativeCorrelation path(DOID:schizophrenia) - pmid:30061532 + pubmed:30988501 - path(MESH:Schizophrenia) association g(HGNC:DISC1) + p(HGNC:IL2) negativeCorrelation path(DOID:"mental depression") - pmid:30061532 + pubmed:30988501 - path(MESH:Schizophrenia) association g(HGNC:DISC1) + p(HGNC:IL2) negativeCorrelation path(DOID:"post-traumatic stress disorder") - pmid:30061532 + pubmed:30967783 - path(MESH:Schizophrenia) association g(HGNC:NRG1) + p(HGNC:IL12B) increases path(MESH:Inflammation) - pmid:30061532 + pubmed:27288790 - path(MESH:Schizophrenia) association g(HGNC:DPYSL2) + p(HGNC:NFKBIA, pmod(go:0006468 ! "protein phosphorylation")) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) - pmid:30061532 + pubmed:26551702 - path(MESH:Schizophrenia) association g(HGNC:DPYSL2) + p(HGNC:NFKBIA, pmod(go:0006468 ! "protein phosphorylation")) increases complex(p(HGNC:BTRC), p(HGNC:CUL1), p(HGNC:NFKBIA), p(HGNC:SKP1)) - pmid:30061532 + pubmed:26551702 - path(MESH:Schizophrenia) association path(MESH:"Psychotic Disorders") + p(HGNC:NFKBIA, pmod(go:0006468 ! "protein phosphorylation")) increases deg(p(HGNC:NFKBIA)) - pmid:30061532 + pubmed:29179999 - path(MESH:Schizophrenia) increases path(MESH:"Psychotic Disorders") + a(CHEBI:resveratrol) decreases p(HGNC:TNF) - pmid:24511233 + pubmed:29179999 - path(MESH:Schizophrenia) association path(MESH:"Psychotic Disorders") + a(CHEBI:resveratrol) decreases p(HGNC:PTGS2) - pmid:30061532 + pubmed:29179999 - path(MESH:Schizophrenia) positiveCorrelation a(CHEBI:dopamine) + a(CHEBI:resveratrol) decreases p(HGNC:PTGS2) - pmid:30061532 + pubmed:29179999 - path(MESH:Schizophrenia) association sec(a(CHEBI:dopamine)) + a(CHEBI:resveratrol) decreases a(MESH:Interleukins) - pmid:30061532 + pubmed:29179999 - path(MESH:Schizophrenia) increases a(CHEBI:dopamine) + a(CHEBI:resveratrol) decreases p(FPLX:"IKK_complex", pmod(go:0006468 ! "protein phosphorylation")) - pmid:30061532 + pubmed:29179999 - path(MESH:Schizophrenia) increases tloc(a(CHEBI:dopamine), fromLoc(MESH:"Nerve Endings"), toLoc(MESH:"Limbic System")) + a(CHEBI:resveratrol) decreases p(HGNC:NFKBIA, pmod(go:0006468 ! "protein phosphorylation")) - pmid:30061532 + pubmed:29179999 - path(MESH:Schizophrenia) decreases p(HGNC:SLC6A3) + a(CHEBI:resveratrol) decreases act(p(FPLX:NFkappaB)) - pmid:30061532 + pubmed:29179999 - path(MESH:Schizophrenia) negativeCorrelation p(HGNC:SLC18A2) + a(CHEBI:resveratrol) decreases p(HGNC:STAT1, pmod(go:0006468 ! "protein phosphorylation")) - pmid:30061532 + pubmed:29179999 - path(MESH:Schizophrenia) association a(CHEBI:"reactive oxygen species") + a(CHEBI:resveratrol) decreases p(HGNC:STAT3, pmod(go:0006468 ! "protein phosphorylation")) - pmid:30061532 + pubmed:29179999 - path(MESH:Schizophrenia) negativeCorrelation bp(GO:"cytoskeleton organization") + a(CHEBI:resveratrol) decreases a(CHEBI:"nitric oxide") - pmid:30061532 + pubmed:29179999 - path(MESH:Schizophrenia) negativeCorrelation bp(GO:"neuron-neuron synaptic transmission") + a(CHEBI:resveratrol) decreases p(HGNC:NOS2) - pmid:30061532 + pubmed:29179999 - path(MESH:Schizophrenia) decreases p(HGNC:MAP2) + a(CHEBI:resveratrol) decreases a(CHEBI:"prostaglandin E2") - pmid:30061532 + pubmed:26551702 - path(MESH:Schizophrenia) decreases a(GO:dendrite) + a(CHEBI:resveratrol) decreases path(MESH:Inflammation) - pmid:30061532 + pubmed:26551702 - path(MESH:Schizophrenia) positiveCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + a(CHEBI:resveratrol) increases act(p(HGNC:NFE2L2)) - pmid:30061532 + pubmed:22020111 - path(MESH:Schizophrenia) increases p(HGNC:MAPT, loc(MESH:Neurons)) + a(CHEBI:resveratrol) decreases act(p(HGNC:NFE2L2)) - pmid:30061532 + pubmed:26551702 - path(MESH:Schizophrenia) decreases bp(GO:"oligodendrocyte development") + a(CHEBI:resveratrol) increases bp(GO:"response to oxidative stress") - pmid:30061532 + pubmed:22020111 - path(MESH:Schizophrenia) association path(MESH:Catatonia) + a(CHEBI:resveratrol) increases act(p(HGNC:SIRT1)) - pmid:30061532 + pubmed:27209302 - path(MESH:Schizophrenia) association p(HGNC:DISC1) + a(CHEBI:resveratrol) increases act(p(HGNC:SIRT1)) - pmid:30061532 + pubmed:30116051 - path(MESH:Schizophrenia) association p(HGNC:DISC1) + a(CHEBI:resveratrol) increases act(p(HGNC:SIRT1)) - pmid:30061532 + pubmed:30688256 - path(MESH:Schizophrenia) association p(HGNC:DTNBP1) + a(CHEBI:resveratrol) decreases act(a(CHEBI:"amyloid-beta polypeptide 42")) - pmid:30061532 + pubmed:30116051 - path(MESH:Schizophrenia) association p(HGNC:DTNBP1) + a(CHEBI:resveratrol) decreases a(CHEBI:"amyloid-beta polypeptide 42") - pmid:30061532 + pubmed:30688256 - path(MESH:Schizophrenia) association p(HGNC:DPYSL2) + a(CHEBI:resveratrol) decreases bp(GO:"apoptotic process") - pmid:30061532 + pubmed:30688256 - path(MESH:Schizophrenia) negativeCorrelation act(a(GO:microtubule)) + a(CHEBI:resveratrol) increases bp(GO:mitophagy) - pmid:30061532 + pubmed:27209302 - path(MESH:Schizophrenia) association bp(GO:"protein kinase B signaling") + a(CHEBI:resveratrol) increases deg(p(CONSO:"amyloid-beta fibrils")) - pmid:30061532 + pubmed:30116051 - path(MESH:Schizophrenia) decreases bp(GO:"protein kinase B signaling") + a(CHEBI:resveratrol) increases act(p(HGNC:CAMKK2)) - pmid:30061532 + pubmed:30116051 - path(MESH:Schizophrenia) association bp(GO:"protein kinase B signaling") + a(CHEBI:resveratrol) decreases a(CHEBI:amyloid-beta) - pmid:30061532 + pubmed:30116051 - path(MESH:Schizophrenia) decreases p(FPLX:AKT) + a(CHEBI:resveratrol) decreases p(HGNC:HTT) - pmid:30061532 + pubmed:30116051 - path(MESH:Schizophrenia) association p(HGNC:NRG1) + a(CHEBI:resveratrol) increases act(p(FPLX:AMPK)) - pmid:30061532 + pubmed:30116051 - path(MESH:Schizophrenia) association p(HGNC:NRG1) + a(CHEBI:resveratrol) decreases act(a(MESH:"amyloid beta-protein (25-35)")) - pmid:30061532 + pubmed:30116051 - path(MESH:Schizophrenia) association p(HGNC:ERBB4) + a(CHEBI:resveratrol) increases p(FPLX:ATG4) - pmid:30061532 + pubmed:30116051 - path(MESH:Schizophrenia) association act(p(HGNC:MTOR)) + a(CHEBI:resveratrol) increases bp(GO:"autophagosome assembly") - pmid:30061532 + pubmed:30116051 - path(MESH:Schizophrenia) negativeCorrelation act(p(HGNC:MTOR)) + a(CHEBI:resveratrol) decreases p(HGNC:AGER) - pmid:30061532 + pubmed:30116051 - path(MESH:Schizophrenia) negativeCorrelation p(HGNC:CDK5R1) + a(CHEBI:resveratrol) decreases p(HGNC:MMP9) - pmid:30061532 + pubmed:29062069 - path(MESH:Schizophrenia) positiveCorrelation act(p(HGNC:CDK5)) + a(CHEBI:resveratrol) decreases p(HGNC:MID1) - pmid:30061532 + pubmed:29062069 - path(MESH:Schizophrenia) association p(HGNC:ULK1, var("?")) + a(CHEBI:resveratrol) increases act(p(HGNC:PPP2CA)) - pmid:30061532 + pubmed:29062069 - path(MESH:Schizophrenia) negativeCorrelation bp(GO:autophagy) + a(CHEBI:resveratrol) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + - pmid:30061532 + pubmed:27288790 - path(MESH:Schizophrenia) negativeCorrelation bp(GO:autophagy) + act(p(FPLX:"IKK_complex")) increases p(FPLX:IKB, pmod(go:0006468 ! "protein phosphorylation")) + + - pmid:30061532 + pubmed:23702978 - path(MESH:Schizophrenia) negativeCorrelation bp(GO:autophagy) + act(p(HGNC:STAT1)) increases act(p(HGNC:SCAF11)) - pmid:30061532 + pubmed:23178521 - path(MESH:Schizophrenia) decreases p(HGNC:BECN1) + p(HGNC:STAT3, pmod(go:0006468 ! "protein phosphorylation")) association a(CHEBI:nicotine) - pmid:30061532 + pubmed:30967783 - path(MESH:Schizophrenia) decreases p(HGNC:BECN1) + a(CHEBI:"prostaglandin E2") increases p(HGNC:TGFB1, loc(MESH:Neuroglia)) - pmid:30061532 + pubmed:30967783 - path(MESH:Schizophrenia) decreases p(HGNC:BECN1) + a(CHEBI:"prostaglandin E2") increases p(HGNC:TGFB1, loc(MESH:Neurons)) - pmid:30061532 + pubmed:30967783 - path(MESH:Schizophrenia) decreases p(HGNC:ULK2) + a(CHEBI:"prostaglandin E2") increases path(EFO:"experimental autoimmune encephalomyelitis") - pmid:30061532 + pubmed:29179999 - path(MESH:Schizophrenia) decreases p(HGNC:ATG3) + a(CHEBI:pterostilbene) regulates p(HGNC:PPARA) - pmid:30061532 + pubmed:29179999 - path(MESH:Schizophrenia) decreases p(HGNC:ADNP) + a(CHEBI:pterostilbene) regulates r(FPLX:NFkappaB) - pmid:30061532 + pubmed:29179999 - path(MESH:Schizophrenia) decreases p(HGNC:ADNP2) + a(CHEBI:pterostilbene) regulates p(FPLX:JNK, pmod(go:0006468 ! "protein phosphorylation")) - pmid:19126755 + pubmed:21718217 - path(MESH:Schizophrenia) negativeCorrelation act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + p(HGNC:PPARA) regulates bp(GO:"lipid oxidation") - pmid:19126755 + pubmed:21718217 - path(MESH:Schizophrenia) association path(MESH:"Sensory Gating") + p(HGNC:PPARA) regulates bp(MESH:"Lipid Peroxidation") - pmid:19126755 + pubmed:22110360 - path(MESH:Schizophrenia) association path(MESH:"Sensory Gating") + p(FPLX:JNK, pmod(go:0006468 ! "protein phosphorylation")) increases act(p(FPLX:JNK)) - pmid:24511233 + pubmed:18494933 - path(MESH:Schizophrenia) association path(MESH:"Cognitive Dysfunction") + p(FPLX:JNK, pmod(go:0006468 ! "protein phosphorylation")) increases act(p(FPLX:JNK)) - pmid:24511233 + pubmed:18494933 - path(MESH:Schizophrenia) association bp(GO:cognition) + p(FPLX:JNK, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation act(p(HGNC:AGER)) - pmid:19721446 + pubmed:18494933 - path(MESH:Schizophrenia) association bp(GO:cognition) + p(FPLX:JNK, pmod(go:0006468 ! "protein phosphorylation")) increases act(p(HGNC:MAPK8)) + + - pmid:24511233 + pubmed:22110360 - path(MESH:Schizophrenia) association bp(GO:behavior) + act(p(FPLX:JNK)) increases bp(GO:"stress-activated protein kinase signaling cascade") + + - pmid:24511233 + pubmed:18494933 - path(MESH:Schizophrenia) decreases bp(GO:"synaptic transmission, cholinergic") + act(p(FPLX:JNK)) increases p(HGNC:DKK1) - pmid:24511233 + pubmed:18494933 - path(MESH:Schizophrenia) association bp(GO:"synaptic transmission, cholinergic") + act(p(FPLX:JNK)) increases p(HGNC:DKK1) - pmid:24511233 + pubmed:27068745 - path(MESH:Schizophrenia) association path(MESH:"Memory, Short-Term") + act(p(FPLX:JNK)) positiveCorrelation p(ECCODE:1.6.3.1) - pmid:24511233 + pubmed:27068745 - path(MESH:Schizophrenia) association path(MESH:Attention) + act(p(FPLX:JNK)) association p(HGNC:CASP3) + + - pmid:24511233 + pubmed:29179999 - path(MESH:Schizophrenia) association path(MESH:"Executive Function") + a(PUBCHEM:44584733) decreases r(HGNC:PTGS2) - pmid:24511233 + pubmed:29179999 - path(MESH:Schizophrenia) association bp(GO:"synaptic transmission, glutamatergic") + a(PUBCHEM:44584733) decreases act(p(FPLX:NFkappaB), ma(GO:"DNA binding")) - pmid:24511233 + pubmed:29179999 - path(MESH:Schizophrenia) association bp(GO:"gamma-aminobutyric acid signaling pathway") + a(PUBCHEM:44584733) decreases bp(GO:"inflammatory response") - pmid:17009926 + pubmed:27288790 - path(MESH:Schizophrenia) association p(FPLX:CHRN) + r(HGNC:PTGS2) increases path(MESH:Inflammation) - pmid:17009926 + pubmed:29179999 - path(MESH:Schizophrenia) association p(FPLX:CHRN) + a(CHEBI:"methyl 3,5-di-O-caffeoyl quinate") decreases bp(GO:"NIK/NF-kappaB signaling") - pmid:21482353 + pubmed:29179999 - path(MESH:Schizophrenia) association act(p(FPLX:CHRN)) + a(CHEBI:"methyl 3,5-di-O-caffeoyl quinate") increases p(HGNC:NFKBIA, pmod(go:0006468 ! "protein phosphorylation")) - pmid:11230871 + pubmed:29179999 - path(MESH:Schizophrenia) association p(FPLX:CHRN) + a(CHEBI:"methyl 3,5-di-O-caffeoyl quinate") increases p(HGNC:MAPK14, pmod(go:0006468 ! "protein phosphorylation")) - pmid:21482353 + pubmed:29179999 - path(MESH:Schizophrenia) positiveCorrelation p(HGNC:CHRNA7, var("?")) + a(CHEBI:"methyl 3,5-di-O-caffeoyl quinate") increases p(FPLX:ERK, pmod(go:0006468 ! "protein phosphorylation")) + + - pmid:21482353 + pubmed:27288790 - path(MESH:Schizophrenia) association bp(GO:"GABAergic neuron differentiation") + p(HGNC:MAPK14) increases act(p(FPLX:NFkappaB)) - pmid:21482353 + pubmed:27288790 - path(MESH:Schizophrenia) increases act(a(MESH:Hippocampus)) + act(p(HGNC:MAPK14)) increases p(HGNC:NFKBIA, pmod(go:0006468 ! "protein phosphorylation")) - pmid:21482353 + pubmed:27288790 - path(MESH:Schizophrenia) association g(HGNC:CHRFAM7A, var("?")) + act(p(HGNC:MAPK14)) increases p(HGNC:NFKBIA, pmod(go:0006468 ! "protein phosphorylation")) - pmid:21482353 + pubmed:27288790 - path(MESH:Schizophrenia) association a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") + act(p(HGNC:MAPK14)) increases tloc(p(HGNC:RELA), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) - pmid:21482353 + pubmed:15601849 - path(MESH:Schizophrenia) positiveCorrelation path(MESH:"Tobacco Use Disorder") + act(p(HGNC:MAPK14), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + - pmid:21482353 + pubmed:30640040 - path(MESH:Schizophrenia) association p(HGNC:PEMT, var("?")) + act(p(HGNC:MAPK14)) increases a(CONSO:"Tau aggregates") - pmid:11230871 + pubmed:23531502 - path(MESH:Schizophrenia) negativeCorrelation a(HBP:"alpha-7-containing nAChR") + act(p(HGNC:MAPK14)) association a(CONSO:"Tau aggregates") - pmid:11230871 + pubmed:30640040 - path(MESH:Schizophrenia) causesNoChange a(HBP:"alpha-4-containing nAChR") + p(HGNC:MAPK14) association a(PUBCHEM:11570805) - pmid:19721446 + pubmed:30640040 - path(MESH:Schizophrenia) association bp(MESH:"Sensory Gating") + p(HGNC:MAPK14) association a(PUBCHEM:156422) - pmid:19721446 + pubmed:30640040 - path(MESH:Schizophrenia) decreases p(HGNC:CHRNA7) + p(HGNC:MAPK14) association a(PUBCHEM:10341154) - pmid:22040696 + pubmed:11943212 - path(MESH:Schizophrenia) negativeCorrelation p(HGNC:CHRNA7) + p(HGNC:MAPK14) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 181)) - pmid:22040696 + pubmed:27594586 - path(MESH:Schizophrenia) positiveCorrelation r(HGNC:RIC3) + p(FPLX:ERK, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation act(p(HGNC:MMP9)) - pmid:30061532 + pubmed:27594586 - g(HGNC:DISC1) association path(MESH:Schizophrenia) + p(FPLX:ERK, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation tloc(p(HGNC:MMP9), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:30061532 + pubmed:29121589 - g(HGNC:DISC1) association path(MESH:Schizophrenia) + p(FPLX:ERK, pmod(go:0006468 ! "protein phosphorylation")) increases act(p(FPLX:ERK)) - pmid:30061532 + pubmed:29179999 - act(g(HGNC:DISC1)) association act(p(HGNC:MTOR)) + a(CHEBI:Salidroside) increases bp(GO:cognition) - pmid:30061532 + pubmed:29179999 - g(HGNC:NRG1) association path(MESH:Schizophrenia) + a(CHEBI:Salidroside) regulates p(HGNC:TXN) - pmid:30061532 + pubmed:29179999 - act(g(HGNC:NRG1)) association act(p(HGNC:MTOR)) + a(CHEBI:Salidroside) regulates p(HGNC:TXNIP) - pmid:21482353 + pubmed:29179999 - g(HGNC:NRG1) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") + a(CHEBI:Salidroside) regulates p(HGNC:RELA) - pmid:30061532 + pubmed:29179999 - g(HGNC:DPYSL2) association path(MESH:Schizophrenia) + a(CHEBI:Salidroside) regulates p(HGNC:NFKBIA) - pmid:30061532 + pubmed:29179999 - g(HGNC:DPYSL2) association path(MESH:Schizophrenia) + a(CHEBI:Salidroside) regulates p(HGNC:CHUK) - pmid:30061532 + pubmed:29179999 - act(g(HGNC:DPYSL2)) association act(p(HGNC:MTOR)) + a(CHEBI:Salidroside) regulates p(HGNC:IKBKB) - pmid:30061532 + pubmed:30962309 - g(HGNC:DPYSL2) increases p(HGNC:DPYSL2) + p(HGNC:TXNIP) increases p(HGNC:NLRP3) - pmid:30061532 + pubmed:30962309 - path(MESH:"Psychotic Disorders") association path(MESH:Schizophrenia) + p(HGNC:TXNIP) increases p(HGNC:NLRP3) + + + + - pmid:24511233 + pubmed:26551702 - path(MESH:"Psychotic Disorders") association path(MESH:Schizophrenia) + act(p(HGNC:IKBKB)) increases p(HGNC:NFKBIA, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + + + + - pmid:30061532 + pubmed:29179999 - path(MESH:"Psychotic Disorders") association p(HGNC:SNCA, var("?")) + a(PUBCHEM:155160) increases bp(GO:memory) - pmid:30061532 + pubmed:29179999 - path(MESH:"Psychotic Disorders") association path(MESH:"Frontotemporal Lobar Degeneration") + a(PUBCHEM:155160) decreases a(CONSO:"amyloid-beta aggregates") - pmid:24511233 + pubmed:29179999 - path(MESH:"Psychotic Disorders") association path(MESH:"Alzheimer Disease") + a(PUBCHEM:155160) decreases path(MESH:"Oxidative Stress") - pmid:24511233 + pubmed:29179999 - path(MESH:"Psychotic Disorders") association path(MESH:"Alzheimer Disease") + a(PUBCHEM:155160) decreases path(MESH:Inflammation) - pmid:24511233 + pubmed:29179999 - path(MESH:"Psychotic Disorders") association path(MESH:"Alzheimer Disease") + a(PUBCHEM:155160) decreases a(CHEBI:"amyloid-beta polypeptide 42") - pmid:24590577 + pubmed:29179999 - path(MESH:"Psychotic Disorders") association p(HGNC:CHRM4) + a(PUBCHEM:155160) decreases act(p(FPLX:"Gamma_secretase")) - pmid:22040696 + pubmed:29179999 - path(MESH:"Psychotic Disorders") negativeCorrelation act(p(HGNC:RIC3), ma(chap)) + a(PUBCHEM:155160) decreases act(p(HGNC:BACE1)) - pmid:30061532 + pubmed:29179999 - a(CHEBI:dopamine) positiveCorrelation path(MESH:Schizophrenia) + a(PUBCHEM:155160) decreases act(p(FPLX:NFkappaB)) - pmid:30061532 + pubmed:27288790 - sec(a(CHEBI:dopamine)) association path(MESH:Schizophrenia) + a(CONSO:"amyloid-beta aggregates") increases act(p(FPLX:"IKK_complex")) - pmid:30061532 + pubmed:27288790 - a(CHEBI:dopamine) regulates bp(GO:autophagy) + a(CONSO:"amyloid-beta aggregates") association p(HGNC:PTGS2) - pmid:30061532 + pubmed:30444369 - a(CHEBI:dopamine) association p(HGNC:SLC18A2) + a(CONSO:"amyloid-beta aggregates") increases path(CONSO:"mitochondrial dysfunction") - pmid:30061532 + pubmed:30444369 - a(CHEBI:dopamine) increases bp(GO:"response to oxidative stress") + a(CONSO:"amyloid-beta aggregates") decreases act(p(FPLX:COX)) - pmid:30061532 + pubmed:19293145 - sec(a(CHEBI:dopamine)) association a(CHEBI:methamphetamine) + a(CONSO:"amyloid-beta aggregates") association path(MESH:"Alzheimer Disease") - pmid:19126755 + pubmed:19293145 - a(CHEBI:dopamine) decreases path(MESH:"Parkinson Disease") + a(CONSO:"amyloid-beta aggregates") increases path(MESH:"Alzheimer Disease") - pmid:21787755 + pubmed:24590577 - sec(a(CHEBI:dopamine)) association r(HGNC:CHRNA6) + a(CONSO:"amyloid-beta aggregates") increases path(MESH:"Alzheimer Disease") - pmid:21787755 + pubmed:25514383 - sec(a(CHEBI:dopamine)) association p(HGNC:CHRNA6) + a(CONSO:"amyloid-beta aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:28391535 + pubmed:22817713 - a(CHEBI:dopamine) regulates path(MESH:Pleasure) + a(CONSO:"amyloid-beta aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:28391535 + pubmed:24511233 - a(CHEBI:dopamine) regulates path(MESH:Motivation) + a(CONSO:"amyloid-beta aggregates") association path(MESH:"Plaque, Amyloid") - pmid:29687724 + pubmed:24590577 - a(CHEBI:dopamine) association path(MESH:Chorea) + a(CONSO:"amyloid-beta aggregates") increases path(MESH:"Plaque, Amyloid") - pmid:29687724 + pubmed:26195256 - a(CHEBI:dopamine) association path(MESH:Dystonia) + a(CONSO:"amyloid-beta aggregates") association path(MESH:"Plaque, Amyloid") - pmid:29687724 + pubmed:17009926 - a(CHEBI:dopamine) association path(MESH:"Huntington Disease") + a(CONSO:"amyloid-beta aggregates") association p(HGNC:CHRNA7) - pmid:27075649 + pubmed:30697142 - a(CHEBI:dopamine) increases a(HBP:HBP00093) + a(CONSO:"amyloid-beta aggregates") directlyIncreases path(CONSO:neurotoxicity) - pmid:27075649 + pubmed:21861815 - a(CHEBI:dopamine) increases a(HBP:HBP00093) + a(CONSO:"amyloid-beta aggregates") increases bp(GO:"neuron death") - pmid:30061532 + pubmed:21722302 - p(HGNC:SLC6A3) increases a(CHEBI:dopamine, loc(MESH:"Nerve Endings")) + a(CONSO:"amyloid-beta aggregates") association path(CONSO:Neurodegeneration) - pmid:30061532 + pubmed:27491084 - a(CHEBI:"lithium(1+)") decreases act(p(HGNC:MTOR)) + a(CONSO:"amyloid-beta aggregates") association p(HGNC:HSPB1) - pmid:30061532 + pubmed:27491084 - a(CHEBI:"lithium(1+)") decreases path(MESH:Schizophrenia) + a(CONSO:"amyloid-beta aggregates") association p(HGNC:CRYAB) - pmid:30061532 + pubmed:27491084 - a(CHEBI:"lithium(1+)") decreases path(MESH:Schizophrenia) + a(CONSO:"amyloid-beta aggregates") association p(HGNC:HSPB6) - pmid:30061532 + pubmed:27491084 - a(CHEBI:"lithium(1+)") decreases path(MESH:"Psychotic Disorders") + a(CONSO:"amyloid-beta aggregates") association p(HGNC:HSPB8) - pmid:18930136 + pubmed:28877763 - a(CHEBI:"lithium(1+)") increases bp(GO:autophagy) + a(CONSO:"amyloid-beta aggregates") positiveCorrelation p(MGI:Syk, pmod(go:0006468 ! "protein phosphorylation")) - pmid:30116051 + pubmed:28877763 - a(CHEBI:"lithium(1+)") increases bp(GO:autophagy) + a(CONSO:"amyloid-beta aggregates") positiveCorrelation act(p(MGI:Syk)) - pmid:29626319 + pubmed:28877763 - a(CHEBI:"lithium(1+)") increases bp(GO:autophagy) + a(CONSO:"amyloid-beta aggregates") positiveCorrelation act(p(HGNC:SYK)) - pmid:27181519 + pubmed:26195256 - a(CHEBI:"lithium(1+)") association bp(GO:autophagy) + a(CONSO:"amyloid-beta aggregates") association path(MESH:"Cerebral Amyloid Angiopathy") - pmid:18930136 + pubmed:26195256 - a(CHEBI:"lithium(1+)") decreases path(HBP:Neurodegeneration) + a(CONSO:"amyloid-beta aggregates", loc(GO:"extracellular region")) negativeCorrelation a(CHEBI:"amyloid-beta polypeptide 42", loc(MESH:"Cerebrospinal Fluid")) - pmid:30116051 + pubmed:26195256 - a(CHEBI:"lithium(1+)") decreases act(p(HGNC:IMPA1)) + a(CONSO:"amyloid-beta aggregates") decreases a(MESH:"Cerebrospinal Fluid") - pmid:30116051 + pubmed:29179999 - a(CHEBI:"lithium(1+)") decreases a(PUBCHEM:55310) + a(CHEBI:"amyloid-beta polypeptide 42") association bp(GO:memory) - pmid:30116051 + pubmed:29179999 - a(CHEBI:"lithium(1+)") decreases p(HGNC:SNCA) + a(CHEBI:"amyloid-beta polypeptide 42") increases bp(GO:"neuron death") - pmid:30116051 + pubmed:27288790 - a(CHEBI:"lithium(1+)") decreases p(HGNC:SOD1) + a(CHEBI:"amyloid-beta polypeptide 42") increases p(FPLX:IKB, pmod(go:0006468 ! "protein phosphorylation", Ser, 32)) - pmid:30116051 + pubmed:27288790 - a(CHEBI:"lithium(1+)") decreases p(HGNC:HTT) + a(CHEBI:"amyloid-beta polypeptide 42") increases p(FPLX:IKB, pmod(go:0006468 ! "protein phosphorylation", Ser, 36)) - pmid:30116051 + pubmed:27288790 - a(CHEBI:"lithium(1+)") decreases p(HGNC:MAPT) + a(CHEBI:"amyloid-beta polypeptide 42") increases p(FPLX:NFkappaB, pmod(go:0006468 ! "protein phosphorylation", Ser, 536)) - pmid:30116051 + pubmed:27288790 - a(CHEBI:"lithium(1+)") increases bp(GO:"motor behavior") + a(CHEBI:"amyloid-beta polypeptide 42") increases r(HGNC:BACE1) - pmid:30061532 + pubmed:27288790 - p(HGNC:SLC18A2) association a(CHEBI:dopamine) + a(CHEBI:"amyloid-beta polypeptide 42") increases r(HGNC:BACE1-AS) - pmid:30061532 + pubmed:25652642 - p(HGNC:SLC18A2) negativeCorrelation path(MESH:Schizophrenia) + a(CHEBI:"amyloid-beta polypeptide 42") regulates p(HGNC:APP) - pmid:30061532 + pubmed:25652642 - p(HGNC:SLC18A2) negativeCorrelation a(CHEBI:methamphetamine) + a(CHEBI:"amyloid-beta polypeptide 42") regulates p(HGNC:BACE1) - pmid:30061532 + pubmed:25652642 - bp(GO:"cytoskeleton organization") negativeCorrelation path(MESH:Schizophrenia) + a(CHEBI:"amyloid-beta polypeptide 42") increases act(complex(GO:"NF-kappaB complex")) - pmid:30061532 + pubmed:25652642 - bp(GO:"cytoskeleton organization") increases bp(GO:"neuron-neuron synaptic transmission") + a(CHEBI:"amyloid-beta polypeptide 42") increases act(complex(GO:"NF-kappaB complex")) - pmid:30061532 + pubmed:25652642 - bp(GO:"cytoskeleton organization") association complex(p(HGNC:CDK5), p(HGNC:DPYSL2)) + a(CHEBI:"amyloid-beta polypeptide 42") increases complex(p(HGNC:NFKB1), p(HGNC:NFKB1), p(HGNC:RELA), p(HGNC:RELA)) - pmid:23454242 + pubmed:25652642 - bp(GO:"cytoskeleton organization") association p(HGNC:PPP2R2A) + a(CHEBI:"amyloid-beta polypeptide 42") regulates bp(GO:"cell death") - pmid:23454242 + pubmed:25652642 - bp(GO:"cytoskeleton organization") association p(HGNC:PPP2R2B) + a(CHEBI:"amyloid-beta polypeptide 42") positiveCorrelation act(a(MESH:Microglia)) - pmid:23454242 + pubmed:25652642 - bp(GO:"cytoskeleton organization") association p(HGNC:PPP2R2C) + a(CHEBI:"amyloid-beta polypeptide 42") increases bp(GO:"positive regulation of advanced glycation end-product receptor activity") - pmid:29311797 + pubmed:25652642 - bp(GO:"cytoskeleton organization") association p(HGNC:HSP90AB1) + a(CHEBI:"amyloid-beta polypeptide 42") increases bp(GO:"peroxisome proliferator activated receptor signaling pathway") - pmid:30061532 + pubmed:25652642 - bp(GO:"microtubule polymerization") increases bp(GO:"cytoskeleton organization") + a(CHEBI:"amyloid-beta polypeptide 42") increases p(MESH:"I-kappa B Proteins", pmod(go:0006468 ! "protein phosphorylation")) - pmid:29238289 + pubmed:29196815 - bp(GO:"microtubule polymerization") association p(HGNC:MAPT) + a(CHEBI:"amyloid-beta polypeptide 42") negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:20133804 + pubmed:19293145 - bp(GO:"microtubule polymerization") positiveCorrelation complex(GO:microtubule) + a(CHEBI:"amyloid-beta polypeptide 42") association path(MESH:"Alzheimer Disease") - - - - - pmid:30061532 + pubmed:19126755 - complex(a(GO:microtubule), a(MESH:"Microtubule-Associated Proteins")) increases bp(GO:"microtubule polymerization") + a(CHEBI:"amyloid-beta polypeptide 42") association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:30061532 + pubmed:19126755 - act(a(GO:microtubule)) negativeCorrelation path(MESH:Schizophrenia) + a(CHEBI:"amyloid-beta polypeptide 42") regulates act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:14556719 + pubmed:19293145 - a(GO:microtubule) association p(HGNC:MAPT) + a(CHEBI:"amyloid-beta polypeptide 42") increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + + - pmid:26631930 + pubmed:19126755 - a(GO:microtubule) negativeCorrelation tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) + a(CHEBI:"amyloid-beta polypeptide 42") increases complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7)) - pmid:18930136 + pubmed:19126755 - a(GO:microtubule) increases bp(GO:"autophagosome-lysosome fusion") + a(CHEBI:"amyloid-beta polypeptide 42") decreases complex(a(MESH:methyllycaconitine), p(HGNC:CHRNA7)) - pmid:8282104 + pubmed:19126755 - a(GO:microtubule) association p(HGNC:CDK5) + a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(HGNC:CHRNA7)) - pmid:8282104 + pubmed:19126755 - a(GO:microtubule) association p(HGNC:PRKACA) + a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(CONSO:"alpha-4 beta-2 nAChR")) - pmid:8282104 + pubmed:25514383 - a(GO:microtubule) association p(FPLX:ERK) + a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(CONSO:"alpha-4 beta-2 nAChR")) - pmid:8282104 + pubmed:19126755 - a(GO:microtubule) association p(FPLX:GSK3) + a(CHEBI:"amyloid-beta polypeptide 42") decreases r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + + + + + + - pmid:16566606 + pubmed:25514383 - a(GO:microtubule) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 18)) + a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(MESH:"Synaptic Potentials") - pmid:16566606 + pubmed:25514383 - a(GO:microtubule) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 29)) + a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(MESH:"Synaptic Potentials") - pmid:16566606 + pubmed:25514383 - a(GO:microtubule) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 197)) + a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(FPLX:CHRN)) - pmid:16566606 + pubmed:25514383 - a(GO:microtubule) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 394)) + a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(FPLX:CHRN)) - pmid:22692785 + pubmed:25514383 - a(MESH:"Microtubule-Associated Proteins") increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + a(CHEBI:"amyloid-beta polypeptide 42") decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) - pmid:22156579 + pubmed:25514383 - a(MESH:"Microtubule-Associated Proteins") positiveCorrelation act(a(HBP:"amyloid-beta oligomers")) + a(CHEBI:"amyloid-beta polypeptide 42") decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) - pmid:30061532 + pubmed:25514383 - bp(GO:"neuron-neuron synaptic transmission") negativeCorrelation path(MESH:Schizophrenia) + a(CHEBI:"amyloid-beta polypeptide 42") increases bp(GO:"long-term synaptic potentiation") - pmid:30061532 + pubmed:19721446 - a(GO:dendrite) association p(HGNC:DISC1) + a(CHEBI:"amyloid-beta polypeptide 42") increases path(CONSO:neurotoxicity) - pmid:30061532 + pubmed:19721446 - path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + a(CHEBI:"amyloid-beta polypeptide 42") increases path(CONSO:neurotoxicity) - pmid:12428809 + pubmed:22908190 - path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HBP:"4R tau") + a(CHEBI:"amyloid-beta polypeptide 42") positiveCorrelation path(CONSO:neurotoxicity) - pmid:26751493 + pubmed:22908190 - path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HBP:"4R tau") + a(CHEBI:"amyloid-beta polypeptide 42") increases path(CONSO:neurotoxicity) - pmid:22299660 + pubmed:19721446 - path(MESH:"Frontotemporal Dementia") association p(FPLX:PPP2) + a(CHEBI:"amyloid-beta polypeptide 42") decreases act(a(CHEBI:nicotine)) - pmid:22299660 + pubmed:19721446 - path(MESH:"Frontotemporal Dementia") association p(HGNC:MAPT, var("?")) + a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(MESH:Neuroprotection) - pmid:29758300 + pubmed:31413141 - path(MESH:"Frontotemporal Dementia") association p(HGNC:MAPT) + a(CHEBI:"amyloid-beta polypeptide 42") negativeCorrelation g(HGNC:APOE) - pmid:28420982 + pubmed:14556719 - path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT) + a(CHEBI:"amyloid-beta polypeptide 42") increases a(CONSO:"amyloid-beta fibrils") - pmid:29758300 + pubmed:22908190 - path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:TARDBP, pmod(HBP:misfolding)) + tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:cytosol), toLoc(GO:lysosome)) positiveCorrelation bp(GO:endocytosis) - pmid:30116051 + pubmed:22908190 - path(MESH:"Frontotemporal Dementia") association p(HGNC:SQSTM1) + tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:cytosol), toLoc(GO:lysosome)) positiveCorrelation g(CONSO:"APOE e4") - pmid:30116051 + pubmed:22908190 - path(MESH:"Frontotemporal Dementia") association p(HGNC:C9orf72) + tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:cytosol), toLoc(GO:lysosome)) positiveCorrelation a(CHEBI:"low-density lipoprotein cholesterol") - pmid:30116051 + pubmed:22908190 - path(MESH:"Frontotemporal Dementia") association path(MESH:"Amyotrophic Lateral Sclerosis") + a(CHEBI:"amyloid-beta polypeptide 42") positiveCorrelation tloc(a(CHEBI:amyloid-beta), fromLoc(GO:cytosol), toLoc(GO:autolysosome)) - pmid:30116051 + pubmed:26195256 - path(MESH:"Frontotemporal Dementia") increases act(p(HGNC:ABL1)) + a(CHEBI:"amyloid-beta polypeptide 42") isA a(CHEBI:amyloid-beta) - pmid:29024336 + pubmed:30116051 - path(MESH:"Frontotemporal Dementia") increases path(MESH:"Proteostasis Deficiencies") + a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(FPLX:AMPK)) - pmid:24027553 + pubmed:22419736 - path(MESH:"Frontotemporal Dementia") association p(HGNC:MAPT, var("p.P301L")) + a(CHEBI:"amyloid-beta polypeptide 42") causesNoChange p(FPLX:AMPK) - pmid:24027553 + pubmed:22419736 - path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:NPEPPS) + a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(FPLX:AMPK)) - pmid:30108137 + pubmed:22419736 - path(MESH:"Frontotemporal Dementia") increases r(HGNC:TFEB) + a(CHEBI:"amyloid-beta polypeptide 42") decreases act(p(FPLX:AMPK)) - pmid:30108137 + pubmed:30116051 - path(MESH:"Frontotemporal Dementia") increases r(HGNC:LAMP1) + a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(GO:"autophagosome assembly") - pmid:30108137 + pubmed:30116051 - path(MESH:"Frontotemporal Dementia") increases p(HGNC:TFEB) + a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:30108137 + pubmed:30116051 - path(MESH:"Frontotemporal Dementia") increases p(HGNC:LAMP1) + a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(GO:"chaperone-mediated autophagy") - pmid:30108137 + pubmed:30116051 - path(MESH:"Frontotemporal Dementia") increases p(HGNC:CTSD) + a(CHEBI:"amyloid-beta polypeptide 42") decreases bp(GO:"chaperone-mediated autophagy") - pmid:28420982 + pubmed:30116051 - path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) + a(CHEBI:"amyloid-beta polypeptide 42") decreases a(GO:microtubule) - pmid:28420982 + pubmed:30116051 - path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 181)) + a(CHEBI:"amyloid-beta polypeptide 42") decreases p(HGNC:IDE) - pmid:26751493 + pubmed:22419736 - path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) + a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:AK1) - pmid:23294633 + pubmed:22419736 - path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) + a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:AK1) - pmid:26751493 + pubmed:22419736 - path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, var("p.Val337Met")) + a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) - pmid:26751493 + pubmed:22419736 - path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, var("p.Gly272Val")) + a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) - pmid:26751493 + pubmed:22419736 - path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, var("p.Arg406Trp")) + a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) - pmid:26751493 + pubmed:22419736 - path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:PSEN1, var("p.Gly183Val")) + a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) - pmid:26631930 + pubmed:22419736 - path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 280)) + a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) - pmid:29980653 + pubmed:22419736 - path(MESH:"Frontotemporal Dementia") isA path(MESH:"Neurodegenerative Diseases") + a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) - pmid:29980653 + pubmed:22419736 - path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:TARDBP) + a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) - pmid:8391280 + pubmed:22419736 - path(MESH:"Frontotemporal Dementia") positiveCorrelation g(DBSNP:rs63750424) + a(CHEBI:"amyloid-beta polypeptide 42") causesNoChange act(p(HGNC:AK3)) - pmid:30061532 + pubmed:22419736 - path(MESH:"Frontotemporal Lobar Degeneration") association path(MESH:"Psychotic Disorders") + a(CHEBI:"amyloid-beta polypeptide 42") increases r(HGNC:AK1) - pmid:30061532 + pubmed:22419736 - path(MESH:"Frontotemporal Lobar Degeneration") association path(MESH:Catatonia) + a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 231)) - pmid:30061532 + pubmed:22419736 - path(MESH:"Frontotemporal Lobar Degeneration") association p(HGNC:TARDBP, loc(GO:"inclusion body")) + a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 235)) - pmid:30061532 + pubmed:22419736 - path(MESH:"Frontotemporal Lobar Degeneration") association p(HGNC:TARDBP, loc(HBP:"dystrophic neurite")) + a(CHEBI:"amyloid-beta polypeptide 42") decreases p(FPLX:AMPK, pmod(go:0006468 ! "protein phosphorylation", Thr, 172)) - pmid:21722302 + pubmed:22419736 - path(MESH:"Frontotemporal Lobar Degeneration") association p(MESH:"TARBP1 protein, human") + a(CHEBI:"amyloid-beta polypeptide 42") decreases p(FPLX:AMPK, pmod(go:0006468 ! "protein phosphorylation", Thr, 172)) - pmid:22908190 + pubmed:22419736 - path(MESH:"Frontotemporal Lobar Degeneration") positiveCorrelation p(HGNC:TARDBP, pmod(Ub)) + a(CHEBI:"amyloid-beta polypeptide 42") decreases p(MESH:"Acetyl-CoA Carboxylase", pmod(go:0006468 ! "protein phosphorylation")) - pmid:26631930 + pubmed:22419736 - path(MESH:"Frontotemporal Lobar Degeneration") association p(HGNC:FUS) + a(CHEBI:"amyloid-beta polypeptide 42") decreases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) - pmid:30061532 + pubmed:26195256 - path(MESH:Catatonia) association path(MESH:"Frontotemporal Lobar Degeneration") + a(CHEBI:"amyloid-beta polypeptide 42", loc(MESH:"Cerebrospinal Fluid")) negativeCorrelation a(CONSO:"amyloid-beta aggregates", loc(GO:"extracellular region")) - pmid:30061532 + pubmed:29626319 - path(MESH:Catatonia) association path(MESH:Schizophrenia) + a(CHEBI:"amyloid-beta polypeptide 42") increases p(HGNC:TREM2) - pmid:30061532 + pubmed:30444369 - p(HGNC:DISC1) association path(MESH:Schizophrenia) + p(FPLX:"Gamma_secretase") increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta polypeptide 42"), p(CONSO:"APP C-terminally truncated carboxyl-terminal fragments"))) - pmid:30061532 + pubmed:26195256 - p(HGNC:DISC1) association path(MESH:Schizophrenia) + p(FPLX:"Gamma_secretase") increases deg(p(CONSO:"APP C-terminally truncated carboxyl-terminal fragments")) - pmid:30061532 + pubmed:29179999 - p(HGNC:DISC1) increases a(HBP:"protein aggregates") + a(CHEBI:lycopene) increases path(MESH:"Spatial Learning") - pmid:30061532 + pubmed:29179999 - p(HGNC:DISC1) association bp(MESH:Neurogenesis) + a(CHEBI:lycopene) increases bp(GO:memory) - pmid:30061532 + pubmed:29179999 - p(HGNC:DISC1) association bp(GO:"neuron migration") + a(CHEBI:lycopene) decreases bp(GO:"NIK/NF-kappaB signaling") - pmid:30061532 + pubmed:29179999 - p(HGNC:DISC1) association bp(GO:"axon development") + a(CHEBI:lycopene) decreases a(MESH:Cytokines) - pmid:30061532 + pubmed:29179999 - p(HGNC:DISC1) association a(GO:dendrite) + a(CHEBI:genistein) decreases p(HGNC:TLR4) - pmid:30061532 + pubmed:29179999 - p(HGNC:DISC1) association a(GO:synapse) + a(CHEBI:genistein) decreases p(FPLX:NFkappaB) - pmid:30061532 + pubmed:29179999 - p(HGNC:DISC1) association bp(GO:"dopamine secretion, neurotransmission") + a(CHEBI:genistein) decreases act(p(FPLX:NFkappaB), ma(GO:"DNA binding")) - - - pmid:30061532 + pubmed:29179999 - p(HGNC:DISC1) decreases act(p(HGNC:CCDC88A)) + a(CHEBI:genistein) decreases act(p(FPLX:NFkappaB)) - pmid:22020111 + pubmed:19293145 - a(HBP:"protein aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:genistein) decreases act(a(CHEBI:amyloid-beta)) - pmid:22020111 + pubmed:19293145 - a(HBP:"protein aggregates") positiveCorrelation path(MESH:"Parkinson Disease") + a(CHEBI:genistein) decreases act(a(CHEBI:"L-glutamate(2-)")) - pmid:22020111 + pubmed:19293145 - a(HBP:"protein aggregates") positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") + a(CHEBI:genistein) decreases p(HGNC:CHRNA7, pmod(go:0006468 ! "protein phosphorylation")) - pmid:29758300 + pubmed:17009926 - a(HBP:"protein aggregates") positiveCorrelation path(MESH:"Neurodegenerative Diseases") + a(CHEBI:genistein) decreases p(HGNC:CHRNA7, pmod(go:0006468 ! "protein phosphorylation")) - pmid:14556719 + pubmed:17009926 - a(HBP:"protein aggregates") decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + a(CHEBI:genistein) causesNoChange tloc(p(FPLX:CHRN), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) - pmid:29980653 + pubmed:17009926 - a(HBP:"protein aggregates", loc(MESH:"Central Nervous System")) increases path(HBP:Neurodegeneration) + a(CHEBI:genistein) regulates p(FPLX:CHRN) - pmid:29980653 + pubmed:27299292 - a(HBP:"protein aggregates") increases path(HBP:Neurodegeneration) + a(CHEBI:genistein) decreases path(DOID:mucopolysaccharidosis) - pmid:27181519 + pubmed:27299292 - a(HBP:"protein aggregates") association complex(p(HGNC:OPTN), p(HGNC:TBK1)) + a(CHEBI:genistein) increases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) - pmid:30061532 + pubmed:30962309 - p(HGNC:DTNBP1) association path(MESH:Schizophrenia) + p(HGNC:TLR4) increases p(HGNC:MYD88) - pmid:30061532 + pubmed:26979166 - p(HGNC:DTNBP1) association path(MESH:Schizophrenia) + act(p(HGNC:TLR4)) increases r(MESH:Cytokines) - pmid:30061532 + pubmed:27314526 - p(HGNC:DTNBP1) increases a(HBP:"protein aggregates") + p(HGNC:TLR4) increases bp(GO:"cytokine secretion") - pmid:30061532 + pubmed:30988501 - p(HGNC:DTNBP1) association a(GO:"microtubule cytoskeleton") + p(HGNC:TLR4) biomarkerFor path(CONSO:neuroinflammation) - pmid:30061532 + pubmed:30988501 - p(HGNC:DTNBP1) association act(a(GO:cytoskeleton)) + p(HGNC:TLR4) biomarkerFor path(CONSO:Neurodegeneration) - pmid:30061532 + pubmed:29179999 - p(HGNC:DTNBP1) association bp(GO:"synaptic vesicle transport") + a(PUBCHEM:45270574) decreases act(a(CHEBI:"amyloid-beta polypeptide 42")) - - - - - - - - - pmid:30106381 + pubmed:29179999 - a(GO:"actin cytoskeleton") association p(HGNC:MTOR) + a(CHEBI:"gallic acid") decreases act(p(FPLX:MYST)) - - - - - - - - - pmid:30061532 + pubmed:29179999 - p(HGNC:DPYSL2) association path(MESH:Schizophrenia) + a(CHEBI:"gallic acid") decreases p(HGNC:RELA, pmod(go:0006473 ! "protein acetylation")) - pmid:30061532 + pubmed:29179999 - p(HGNC:DPYSL2) association bp(GO:"axon development") + a(CHEBI:"gallic acid") decreases path(MESH:Inflammation) - pmid:30061532 + pubmed:29179999 - p(HGNC:DPYSL2) regulates a(GO:"dendritic spine") + a(CHEBI:"gallic acid") decreases act(p(FPLX:NFkappaB)) - - - - - - - - - pmid:30061532 + pubmed:29179999 - a(GO:"microtubule cytoskeleton") association p(HGNC:DTNBP1) + a(CHEBI:"gallic acid") decreases act(a(CHEBI:amyloid-beta)) - pmid:24653673 + pubmed:29179999 - a(GO:"microtubule cytoskeleton") negativeCorrelation act(p(HGNC:GSK3B)) + p(HGNC:RELA, pmod(go:0006473 ! "protein acetylation")) association path(MESH:"Neurotoxicity Syndromes") - pmid:24653673 + pubmed:29179999 - a(GO:"microtubule cytoskeleton") negativeCorrelation act(p(HGNC:CDK5)) + path(MESH:"Neurotoxicity Syndromes") association p(HGNC:RELA, pmod(go:0006473 ! "protein acetylation")) - pmid:24653673 + pubmed:30515821 - a(GO:"microtubule cytoskeleton") negativeCorrelation act(p(FPLX:ERK)) + path(MESH:"Neurotoxicity Syndromes") increases bp(GO:"programmed cell death") - pmid:30061532 + pubmed:29179999 - act(a(GO:cytoskeleton)) association p(HGNC:DTNBP1) + a(CHEBI:galanthamine) decreases act(p(HGNC:ACHE)) - pmid:30061532 + pubmed:19126755 - bp(GO:"synaptic vesicle transport") association p(HGNC:DTNBP1) + a(CHEBI:galanthamine) decreases p(HGNC:ACHE) - pmid:14556719 + pubmed:19293145 - bp(GO:"synaptic vesicle transport") association p(HGNC:SYT11, pmod(Ub)) + a(CHEBI:galanthamine) decreases act(p(HGNC:ACHE)) - pmid:30061532 + pubmed:11230871 - p(HGNC:MAP6) association act(p(HGNC:MTOR)) + a(CHEBI:galanthamine) decreases act(p(HGNC:ACHE)) - pmid:30061532 + pubmed:29179999 - bp(MESH:Neurogenesis) association p(HGNC:DISC1) + a(CHEBI:galanthamine) increases a(CHEBI:acetylcholine) - pmid:30061532 + pubmed:29179999 - bp(GO:"neuron migration") association p(HGNC:DISC1) + a(CHEBI:galanthamine) increases tloc(a(CHEBI:acetylcholine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:30061532 + pubmed:29179999 - bp(GO:"axon development") association p(HGNC:DISC1) + a(CHEBI:galanthamine) increases a(MESH:"Cholinergic Agents") + + - pmid:30061532 + pubmed:29179999 - bp(GO:"axon development") association p(HGNC:DPYSL2) + a(CHEBI:galanthamine) increases act(p(HGNC:HMOX1)) - pmid:30061532 + pubmed:29179999 - p(HGNC:DISC1, var("?")) increases path(MESH:Schizophrenia) + a(CHEBI:galanthamine) increases act(p(FPLX:NFkappaB)) - pmid:30061532 + pubmed:30444369 - p(HGNC:DISC1, var("?")) increases path(MESH:Schizophrenia) + a(CHEBI:galanthamine) increases bp(GO:cognition) - pmid:30061532 + pubmed:26813123 - p(HGNC:DISC1, var("?")) decreases sec(a(CHEBI:dopamine)) + a(CHEBI:galanthamine) increases bp(GO:cognition) - pmid:30061532 + pubmed:30444369 - p(HGNC:DISC1, var("?")) increases act(p(FPLX:AKT)) + a(CHEBI:galanthamine) decreases act(p(FPLX:Cholinesterase)) - pmid:30061532 + pubmed:19126755 - p(HGNC:DISC1, var("?")) increases act(p(HGNC:MTOR)) + a(CHEBI:galanthamine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:30061532 + pubmed:19126755 - p(HGNC:DISC1, var("?")) decreases bp(GO:autophagy) + a(CHEBI:galanthamine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:30061532 + pubmed:19126755 - p(HGNC:CCDC88A) increases act(p(FPLX:AKT)) + a(CHEBI:galanthamine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - - - pmid:30061532 + pubmed:19126755 - complex(p(FPLX:AKT), p(HGNC:CCDC88A)) increases act(p(FPLX:AKT)) + a(CHEBI:galanthamine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - - - - - - - pmid:30061532 + pubmed:19293145 - complex(p(HGNC:CCDC88A), p(HGNC:DISC1)) decreases act(p(FPLX:AKT)) + a(CHEBI:galanthamine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:30061532 + pubmed:19126755 - complex(p(HGNC:CCDC88A), p(HGNC:DISC1)) decreases act(p(FPLX:AKT)) + a(CHEBI:galanthamine) decreases path(CONSO:Neurodegeneration) - pmid:30061532 + pubmed:19126755 - complex(p(HGNC:CCDC88A), p(HGNC:DISC1)) decreases act(p(HGNC:MTOR)) + a(CHEBI:galanthamine) increases bp(GO:"synaptic transmission, cholinergic") - pmid:30061532 + pubmed:19293145 - p(MGI:Rictor) decreases bp(GO:"protein kinase B signaling") + a(CHEBI:galanthamine) isA a(CHEBI:"EC 3.1.1.8 (cholinesterase) inhibitor") - pmid:30061532 + pubmed:19293145 - p(HGNC:NRG1) association path(MESH:Schizophrenia) + a(CHEBI:galanthamine) decreases path(MESH:"Alzheimer Disease") - pmid:30061532 + pubmed:19293145 - p(HGNC:NRG1) association path(MESH:Schizophrenia) + act(a(CHEBI:galanthamine)) increases bp(MESH:Neuroprotection) - pmid:30061532 + pubmed:19293145 - p(HGNC:NRG1) regulates p(HGNC:DISC1) + a(CHEBI:galanthamine) increases p(HGNC:BCL2) - pmid:30061532 + pubmed:24511233 - p(HGNC:NRG1) association bp(GO:"protein kinase B signaling") + a(CHEBI:galanthamine) isA a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") - pmid:30061532 + pubmed:17009926 - p(HGNC:NRG1) association act(p(HGNC:MTOR)) + a(CHEBI:galanthamine) isA a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") - - - - - pmid:30061532 + pubmed:17009926 - complex(p(HGNC:ERBB4), p(HGNC:NRG1)) regulates bp(GO:"generation of neurons") + a(CHEBI:galanthamine) increases act(p(FPLX:CHRN)) - pmid:30061532 + pubmed:11230871 - complex(p(HGNC:ERBB4), p(HGNC:NRG1)) regulates bp(GO:"neuron-neuron synaptic transmission") + a(CHEBI:galanthamine) increases act(p(FPLX:CHRN)) - pmid:30061532 + pubmed:11230871 - act(complex(p(HGNC:ERBB4), p(HGNC:NRG1))) increases sec(a(CHEBI:dopamine)) + a(CHEBI:galanthamine) increases p(FPLX:CHRN) - pmid:21482353 + pubmed:26813123 - bp(GO:"generation of neurons") association act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + a(CHEBI:galanthamine) decreases path(MESH:Death) - - - pmid:30061532 + pubmed:25881725 - complex(p(FPLX:PI3K), p(HGNC:ERBB4)) increases act(p(FPLX:PI3K)) + a(CHEBI:galanthamine) decreases act(p(MGI:App, frag("25_35"))) - - - pmid:30061532 + pubmed:25881725 - act(p(FPLX:PI3K), ma(kin)) increases p(FPLX:AKT, pmod(Ph)) + a(CHEBI:galanthamine) increases bp(GO:learning) - pmid:30061532 + pubmed:25881725 - act(p(FPLX:PI3K)) increases act(p(FPLX:AKT)) + a(CHEBI:galanthamine) increases path(MESH:"Spatial Memory") - pmid:19293145 + pubmed:25881725 - p(FPLX:PI3K) increases act(a(CHEBI:nicotine)) + a(CHEBI:galanthamine) causesNoChange r(MGI:Chrna7) - pmid:19293145 + pubmed:25881725 - act(p(FPLX:PI3K)) increases act(a(MESH:"Cholinesterase Inhibitors")) + a(CHEBI:galanthamine) increases p(MGI:Chrna7) - pmid:19293145 + pubmed:25881725 - act(p(FPLX:PI3K)) increases act(p(HGNC:BAD)) + a(CHEBI:galanthamine) increases p(MGI:Chrna7) - pmid:19293145 + pubmed:19721446 - p(FPLX:PI3K) increases act(a(MESH:Synapses)) + a(CHEBI:galanthamine) regulates p(HGNC:CHRNA7) - pmid:19293145 + pubmed:19721446 - act(p(FPLX:PI3K)) decreases bp(GO:"apoptotic process") + a(CHEBI:galanthamine) decreases path(MESH:Schizophrenia) - pmid:19293145 + pubmed:29179999 - p(FPLX:PI3K) regulates act(a(CHEBI:estrogen)) + complex(a(CHEBI:galanthamine), p(FPLX:CHRN)) increases act(p(FPLX:CHRN)) + + - pmid:22040696 + pubmed:17009926 - act(p(FPLX:PI3K)) decreases bp(GO:"neuron death") + p(FPLX:CHRN) increases bp(GO:"neurotransmitter secretion") - pmid:30116051 + pubmed:17009926 - act(p(FPLX:PI3K)) increases a(GO:"autophagosome membrane") + act(p(FPLX:CHRN)) increases bp(GO:"neurotransmitter secretion") - pmid:25514383 + pubmed:17009926 - p(FPLX:AKT, pmod(Ph)) decreases bp(GO:"apoptotic process") + p(FPLX:CHRN) increases bp(GO:"neurotransmitter secretion") - pmid:30985105 + pubmed:17009926 - p(FPLX:AKT, pmod(Ph)) decreases bp(GO:autophagy) + p(FPLX:CHRN) regulates bp(GO:"rhythmic excitation") - pmid:30061532 + pubmed:17009926 - a(GO:"dendritic spine") positiveCorrelation p(HGNC:CDK5) + p(FPLX:CHRN) regulates bp(GO:"rhythmic excitation") - pmid:27671637 + pubmed:17009926 - a(GO:"dendritic spine") negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) + p(FPLX:CHRN) regulates bp(GO:"neuron remodeling") - pmid:27807169 + pubmed:17009926 - a(GO:"dendritic spine") positiveCorrelation p(RGD:Cdk5r2) + p(FPLX:CHRN) association bp(GO:"regulation of synaptic plasticity") - pmid:22156579 + pubmed:17009926 - a(GO:"dendritic spine") negativeCorrelation p(HGNC:MARK4) + act(p(FPLX:CHRN)) increases bp(GO:"regulation of synaptic plasticity") - pmid:30061532 + pubmed:17009926 - a(CHEBI:amphetamine) increases g(HGNC:CDK5) + p(FPLX:CHRN) association bp(GO:"regulation of synaptic plasticity") - pmid:30061532 + pubmed:17009926 - a(CHEBI:amphetamine) increases p(HGNC:CDK5) + p(FPLX:CHRN) association path(MESH:Attention) - pmid:24511233 + pubmed:17009926 - act(a(CHEBI:amphetamine)) increases bp(GO:locomotion) + p(FPLX:CHRN) association bp(GO:learning) - pmid:30061532 + pubmed:17009926 - p(HGNC:CDK5R1, frag("?")) increases act(p(HGNC:CDK5)) + p(FPLX:CHRN) association bp(GO:memory) - - - - - pmid:30061532 + pubmed:11230871 - complex(p(HGNC:CDK5), p(HGNC:DPYSL2)) association bp(GO:"cytoskeleton organization") + p(FPLX:CHRN) association bp(GO:memory) - pmid:30061532 + pubmed:17009926 - complex(p(HGNC:CDK5), p(HGNC:DPYSL2)) association path(MESH:"Mental Disorders") + p(FPLX:CHRN) association bp(GO:"developmental process") - pmid:30061532 + pubmed:17009926 - path(MESH:"Mental Disorders") association complex(p(HGNC:CDK5), p(HGNC:DPYSL2)) + p(FPLX:CHRN) association path(MESH:Schizophrenia) - pmid:30061532 + pubmed:17009926 - p(HGNC:ULK1, var("?")) association path(MESH:Schizophrenia) + p(FPLX:CHRN) association path(MESH:Schizophrenia) - - - - - pmid:30116051 + pubmed:21482353 - p(HGNC:ULK1) increases bp(GO:macroautophagy) + act(p(FPLX:CHRN)) association path(MESH:Schizophrenia) - - - - - - - pmid:30116051 + pubmed:11230871 - act(p(HGNC:ULK1)) increases bp(GO:"autophagosome assembly") + p(FPLX:CHRN) association path(MESH:Schizophrenia) - pmid:30116051 + pubmed:17009926 - act(p(HGNC:ULK1)) increases p(HGNC:AMBRA1, pmod(Ph)) + p(FPLX:CHRN) association path(MESH:Epilepsy) - pmid:30116051 + pubmed:17009926 - act(p(HGNC:ULK1)) increases p(HGNC:BECN1, pmod(Ph)) + p(FPLX:CHRN) association path(MESH:Epilepsy) - pmid:23528736 + pubmed:11230871 - p(HGNC:ULK1) increases bp(GO:autophagy) + p(FPLX:CHRN) association path(MESH:Epilepsy) - pmid:30061532 + pubmed:17009926 - p(HGNC:BECN1) association bp(GO:autophagy) + p(FPLX:CHRN) association path(MESH:"Autistic Disorder") - pmid:18930136 + pubmed:17009926 - p(HGNC:BECN1) increases bp(GO:autophagy) + act(p(FPLX:CHRN)) negativeCorrelation path(MESH:"Autistic Disorder") - pmid:26702100 + pubmed:17009926 - p(HGNC:BECN1) association bp(GO:autophagy) + p(FPLX:CHRN) negativeCorrelation path(MESH:"Autistic Disorder") - - - pmid:29758300 + pubmed:17009926 - p(HGNC:BECN1) negativeCorrelation path(MESH:"Alzheimer Disease") + p(FPLX:CHRN) association path(MESH:"Alzheimer Disease") - - - pmid:29758300 + pubmed:17009926 - p(HGNC:BECN1) decreases a(MESH:"Amyloid beta-Peptides") + act(p(FPLX:CHRN)) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:29758300 + pubmed:17009926 - p(HGNC:BECN1) association bp(GO:macroautophagy) + p(FPLX:CHRN) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:29758300 + pubmed:17009926 - p(HGNC:BECN1) association bp(GO:endocytosis) + p(FPLX:CHRN) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:29758300 + pubmed:11230871 - p(HGNC:BECN1) increases bp(GO:phagocytosis) + p(FPLX:CHRN) association path(MESH:"Alzheimer Disease") - pmid:30116051 + pubmed:11230871 - act(p(HGNC:BECN1)) increases bp(GO:"autophagosome assembly") + p(FPLX:CHRN) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:27260836 + pubmed:17009926 - p(HGNC:BECN1) positiveCorrelation p(HGNC:PICALM) + p(FPLX:CHRN) association path(MESH:"Behavior, Addictive") - pmid:30061532 + pubmed:26472524 - p(HGNC:ULK2) association bp(GO:autophagy) + act(p(FPLX:CHRN)) increases path(MESH:"Behavior, Addictive") - pmid:30061532 + pubmed:17009926 - p(HGNC:ATG3) association bp(GO:autophagy) + p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Monovalent"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) - pmid:30061532 + pubmed:17009926 - p(HGNC:ADNP) increases bp(GO:"brain development") + p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Monovalent"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) - - - pmid:30106381 + pubmed:26472524 - p(HGNC:ADNP) association bp(GO:autophagy) + p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Monovalent"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) - pmid:30106381 + pubmed:26472524 - p(HGNC:ADNP) association bp(GO:autophagy) + p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Monovalent"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) - pmid:30106381 + pubmed:17009926 - p(HGNC:ADNP) association bp(GO:"cell adhesion") + p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Divalent"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) - pmid:30106381 + pubmed:17009926 - p(HGNC:ADNP) association bp(GO:"immune response") + p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Divalent"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) - pmid:30106381 + pubmed:26472524 - p(HGNC:ADNP) association path(MESH:"Autistic Disorder") + p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Divalent"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) - pmid:29724491 + pubmed:26472524 - p(HGNC:ADNP) decreases path(MESH:"Autistic Disorder") + p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Divalent"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) - pmid:30106381 + pubmed:17009926 - p(HGNC:ADNP) association act(a(GO:synapse)) + act(p(FPLX:CHRN)) increases bp(GO:"membrane depolarization") - pmid:30106381 + pubmed:17009926 - p(HGNC:ADNP) association bp(GO:"nervous system development") + act(p(FPLX:CHRN)) increases bp(GO:"membrane depolarization") - pmid:30106381 + pubmed:17009926 - p(HGNC:ADNP) association bp(GO:"synapse assembly") + act(p(FPLX:CHRN)) increases bp(GO:"membrane depolarization") - pmid:30106381 + pubmed:26472524 - p(HGNC:ADNP) positiveCorrelation bp(GO:"synaptic transmission, glutamatergic") + act(p(FPLX:CHRN)) increases bp(GO:"membrane depolarization") - pmid:30106381 + pubmed:17009926 - p(HGNC:ADNP) regulates bp(GO:"synapse organization") + act(p(FPLX:CHRN)) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) - pmid:30106381 + pubmed:26472524 - p(HGNC:ADNP) regulates bp(GO:"cell communication") + p(FPLX:CHRN) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) - pmid:30106381 + pubmed:26472524 - p(HGNC:ADNP) association bp(GO:"AMPA glutamate receptor clustering") + p(FPLX:CHRN) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) - pmid:30106381 + pubmed:25514383 - p(HGNC:ADNP) association bp(GO:learning) + act(p(FPLX:CHRN)) increases a(CHEBI:"calcium(2+)") - pmid:30106381 + pubmed:17009926 - p(HGNC:ADNP) association bp(GO:memory) + act(p(FPLX:CHRN)) increases tloc(a(CHEBI:"glutamate(2-)"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:30664622 + pubmed:17009926 - p(HGNC:ADNP) increases bp(GO:memory) + p(FPLX:CHRN) increases tloc(a(CHEBI:"glutamate(2-)"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:30106381 + pubmed:26472524 - p(HGNC:ADNP) association bp(GO:"social behavior") + act(p(FPLX:CHRN)) increases tloc(a(CHEBI:"glutamate(2-)"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:30664622 + pubmed:17009926 - p(HGNC:ADNP) increases bp(GO:"social behavior") + p(FPLX:CHRN) increases tloc(a(CHEBI:"gamma-aminobutyric acid"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:30106381 + pubmed:17009926 - p(HGNC:ADNP) regulates bp(GO:"ion transport") + p(FPLX:CHRN) regulates act(complex(GO:"GABA-A receptor complex")) - pmid:30106381 + pubmed:17009926 - p(HGNC:ADNP) association bp(GO:"vocalization behavior") + act(p(FPLX:CHRN)) increases bp(GO:"long term synaptic depression") - pmid:30106381 + pubmed:17009926 - p(HGNC:ADNP) regulates p(HGNC:APOE) + act(p(FPLX:CHRN)) increases bp(GO:"regulation of action potential firing rate") - pmid:30106381 + pubmed:17009926 - p(HGNC:ADNP) association g(HGNC:"IQCJ-SCHIP1") + p(FPLX:CHRN) association bp(GO:"regulation of action potential firing rate") - pmid:30106381 + pubmed:17009926 - p(HGNC:ADNP) association p(HGNC:NLGN2) + p(FPLX:CHRN) increases bp(GO:"regulation of action potential firing rate") - pmid:30106381 + pubmed:17009926 - p(HGNC:ADNP) regulates p(HGNC:PAX6) + p(FPLX:CHRN) association bp(GO:"regulation of action potential firing pattern") - pmid:30106381 + pubmed:17009926 - p(HGNC:ADNP) association p(HGNC:WFS1) + act(p(FPLX:CHRN)) negativeCorrelation path(MESH:"Lewy Body Disease") - pmid:30106381 + pubmed:17009926 - p(HGNC:ADNP) association path(MESH:Inflammation) + p(FPLX:CHRN) negativeCorrelation path(MESH:"Lewy Body Disease") - pmid:30106381 + pubmed:17009926 - p(HGNC:ADNP) association path(MESH:Intelligence) + act(p(FPLX:CHRN)) negativeCorrelation path(MESH:"Down Syndrome") - pmid:30106381 + pubmed:17009926 - p(HGNC:ADNP) regulates p(HGNC:MTOR) + p(FPLX:CHRN) negativeCorrelation path(MESH:"Down Syndrome") - pmid:30664622 + pubmed:17009926 - p(HGNC:ADNP) decreases path(MESH:"Motor Skills Disorders") + act(p(FPLX:CHRN)) negativeCorrelation path(MESH:"Parkinson Disease") - pmid:30664622 + pubmed:17009926 - p(HGNC:ADNP) increases a(MESH:"Nerve Fibers, Myelinated") + p(FPLX:CHRN) negativeCorrelation path(MESH:"Parkinson Disease") - pmid:30664622 + pubmed:11230871 - act(p(HGNC:ADNP)) association a(GO:"glutamatergic synapse") + p(FPLX:CHRN) association path(MESH:"Parkinson Disease") - pmid:30664622 + pubmed:17009926 - p(HGNC:ADNP) increases a(GO:"dendritic spine") + p(FPLX:CHRN) association bp(GO:"response to pain") - pmid:30664622 + pubmed:17009926 - act(p(HGNC:ADNP)) association p(HGNC:DLG4) + p(FPLX:CHRN) association path(MESH:Anxiety) - pmid:29724491 + pubmed:11230871 - p(HGNC:ADNP) decreases path(MESH:"Intellectual Disability") + p(FPLX:CHRN) association path(MESH:Anxiety) - pmid:29724491 + pubmed:17009926 - p(HGNC:ADNP) decreases path(MESH:"Developmental Disabilities") + p(FPLX:CHRN) association path(MESH:Depression) - pmid:29724491 + pubmed:11230871 - p(HGNC:ADNP) increases bp(GO:"motor behavior") + p(FPLX:CHRN) association path(MESH:Depression) - - - pmid:29724491 + pubmed:17009926 - p(HGNC:ADNP) decreases path(MESH:"Muscle Hypotonia") + act(p(FPLX:CHRN)) increases path(MESH:Arousal) - pmid:29724491 + pubmed:28445721 - p(HGNC:ADNP) decreases path(MESH:"Muscle Hypertonia") + p(FPLX:CHRN) association path(MESH:Arousal) - pmid:29724491 + pubmed:17009926 - p(HGNC:ADNP) decreases path(MESH:"Language Development Disorders") + act(p(FPLX:CHRN)) increases bp(GO:"circadian sleep/wake cycle, REM sleep") - pmid:29724491 + pubmed:26472524 - p(HGNC:ADNP) decreases path(MESH:Seizures) + p(FPLX:CHRN) increases tloc(a(CHEBI:"sodium(1+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) - pmid:29724491 + pubmed:26472524 - p(HGNC:ADNP) decreases path(MESH:Epilepsy) + p(FPLX:CHRN) increases tloc(a(CHEBI:"sodium(1+)"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) - pmid:29724491 + pubmed:26472524 - p(HGNC:ADNP) decreases path(MESH:"Autism Spectrum Disorder") + p(FPLX:CHRN) increases tloc(a(CHEBI:"potassium(1+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) - pmid:29724491 + pubmed:26472524 - p(HGNC:ADNP) increases bp(GO:"sensory processing") + p(FPLX:CHRN) increases tloc(a(CHEBI:"potassium(1+)"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) - pmid:29724491 + pubmed:26813123 - p(HGNC:ADNP) decreases path(MESH:"Compulsive Behavior") + p(FPLX:CHRN) increases bp(GO:cognition) - pmid:29724491 + pubmed:25514383 - p(HGNC:ADNP) decreases path(MESH:"Mood Disorders") + p(FPLX:CHRN) regulates bp(GO:cognition) - pmid:29724491 + pubmed:28445721 - p(HGNC:ADNP) decreases path(MESH:Anxiety) + p(FPLX:CHRN) association bp(GO:cognition) - pmid:29724491 + pubmed:28445721 - p(HGNC:ADNP) increases path(MESH:Morale) + p(FPLX:CHRN) association bp(GO:cognition) - pmid:29724491 + pubmed:28445721 - p(HGNC:ADNP) decreases path(MESH:"Self-Injurious Behavior") + p(FPLX:CHRN) association bp(GO:cognition) - pmid:29724491 + pubmed:11230871 - p(HGNC:ADNP) decreases path(MESH:Aggression) + p(FPLX:CHRN) association bp(GO:cognition) - pmid:29724491 + pubmed:26813123 - p(HGNC:ADNP) decreases path(MESH:"Attention Deficit Disorder with Hyperactivity") + p(FPLX:CHRN) decreases path(CONSO:Neurodegeneration) + + + + + + + + + + - pmid:29724491 + pubmed:25514383 - p(HGNC:ADNP) increases bp(GO:sleep) + p(FPLX:CHRN) isA a(MESH:"Cysteine Loop Ligand-Gated Ion Channel Receptors") + + - pmid:29724491 + pubmed:25514383 - p(HGNC:ADNP) decreases path(MESH:"Malformations of Cortical Development") + p(FPLX:CHRN) regulates bp(GO:"potassium ion transport") - pmid:29724491 + pubmed:25514383 - p(HGNC:ADNP) increases path(MESH:"Vision, Ocular") + p(FPLX:CHRN) regulates bp(GO:"sodium ion transport") - pmid:29724491 + pubmed:25514383 - p(HGNC:ADNP) decreases path(MESH:Hyperopia) + p(FPLX:CHRN) regulates bp(GO:"calcium ion transport") + + - pmid:29724491 + pubmed:25514383 - p(HGNC:ADNP) decreases path(MESH:Strabismus) + act(p(FPLX:CHRN)) increases bp(MESH:"Synaptic Potentials") - pmid:29724491 + pubmed:25514383 - p(HGNC:ADNP) decreases path(MESH:Myopia) + p(FPLX:CHRN) regulates path(MESH:"Cognition Disorders") + + - pmid:29724491 + pubmed:28445721 - p(HGNC:ADNP) decreases path(MESH:Astigmatism) + p(FPLX:CHRN) association path(MESH:Motivation) - pmid:30985105 + pubmed:28445721 - bp(GO:"brain development") association p(HGNC:OGT) + act(p(FPLX:CHRN)) increases act(a(MESH:"Dopaminergic Neurons")) - - - - - pmid:30061532 + pubmed:28445721 - p(HGNC:MAP1LC3A) increases bp(GO:"autophagosome assembly") + p(FPLX:CHRN) increases bp(GO:"positive regulation of synaptic plasticity") - pmid:30061532 + pubmed:28445721 - p(HGNC:MAP1LC3A) increases bp(GO:"autophagosome maturation") + p(FPLX:CHRN) increases bp(GO:"dopamine secretion") - pmid:24027553 + pubmed:28445721 - p(HGNC:MAP1LC3A) association path(MESH:"Plaque, Amyloid") + p(FPLX:CHRN) association path(MESH:"Tobacco Use Disorder") - pmid:27181519 + pubmed:21482353 - p(HGNC:MAP1LC3A) increases a(GO:phagophore) + act(p(FPLX:CHRN)) association path(MESH:"Tobacco Use Disorder") + + + + - pmid:27181519 + pubmed:21482353 - act(p(HGNC:MAP1LC3A)) positiveCorrelation g(HGNC:C9orf72) + p(FPLX:CHRN) increases tloc(a(CHEBI:neurotransmitter), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) - pmid:30061532 + pubmed:11230871 - a(PUBCHEM:9832404) increases r(HGNC:BECN1) + act(p(FPLX:CHRN)) regulates tloc(a(CHEBI:neurotransmitter), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) + + + + + + + + + + - pmid:30061532 + pubmed:21482353 - a(PUBCHEM:9832404) increases r(HGNC:ADNP) + act(p(FPLX:CHRN)) association complex(p(FPLX:CHRN), p(HGNC:LYNX1)) - pmid:30061532 + pubmed:21482353 - a(PUBCHEM:9832404) increases complex(p(HGNC:ADNP), p(HGNC:MAP1LC3A)) + tloc(p(FPLX:CHRN), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) association complex(p(FPLX:CHRN), p(HGNC:LYNX1)) + + - pmid:30061532 + pubmed:21482353 - a(PUBCHEM:9832404) decreases bp(GO:"neuron death") + p(FPLX:CHRN) regulates p(HGNC:LYNX1) - pmid:30061532 + pubmed:21482353 - a(PUBCHEM:9832404) increases bp(GO:cognition) + act(p(FPLX:CHRN)) negativeCorrelation act(a(MESH:Brain)) - pmid:30061532 + pubmed:21482353 - a(PUBCHEM:9832404) decreases path(MESH:"Mental Disorders") + act(p(FPLX:CHRN)) negativeCorrelation a(MESH:Neurons) - pmid:30106381 + pubmed:21482353 - a(PUBCHEM:9832404) increases a(GO:"dendritic spine") + p(FPLX:CHRN) regulates bp(GO:"GABAergic neuron differentiation") - pmid:30106381 + pubmed:21482353 - a(PUBCHEM:9832404) increases a(GO:"dendritic spine") + p(FPLX:CHRN) increases act(a(HP:"inhibitory interneuron")) - pmid:30106381 + pubmed:21482353 - a(PUBCHEM:9832404) increases a(GO:"dendritic spine") + p(FPLX:CHRN) increases act(p(FPLX:NOS)) - pmid:30106381 + pubmed:11230871 - a(PUBCHEM:9832404) decreases p(HGNC:DLG4) + p(FPLX:CHRN) association a(MESH:"Neurotransmitter Agents") - pmid:30106381 + pubmed:11230871 - a(PUBCHEM:9832404) decreases p(HGNC:DLG4) + p(FPLX:CHRN) association path(MESH:"Tourette Syndrome") + + - pmid:30106381 + pubmed:11230871 - a(PUBCHEM:9832404) causesNoChange p(HGNC:DLG4) + p(FPLX:CHRN) negativeCorrelation path(MESH:"Cognitive Dysfunction") - pmid:30106381 + pubmed:11230871 - a(PUBCHEM:9832404) increases p(HGNC:DLG4) + p(FPLX:CHRN) negativeCorrelation p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) - pmid:30664622 + pubmed:11230871 - act(a(PUBCHEM:9832404)) association p(HGNC:DLG4) + p(FPLX:CHRN) negativeCorrelation a(MESH:"Amyloid beta-Peptides") - pmid:30106381 + pubmed:11230871 - a(PUBCHEM:9832404) decreases a(GO:"dendritic shaft") + p(FPLX:CHRN) negativeCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:30106381 + pubmed:11230871 - a(PUBCHEM:9832404) decreases a(GO:"dendritic shaft") + p(FPLX:CHRN) negativeCorrelation bp(GO:"response to oxidative stress") + + + + + + - pmid:30106381 + pubmed:21787755 - a(PUBCHEM:9832404) increases a(GO:"excitatory synapse") + p(FPLX:CHRN) increases bp(GO:"maintenance of synapse structure") - pmid:30106381 + pubmed:21787755 - a(PUBCHEM:9832404) association bp(GO:autophagy) + p(FPLX:CHRN) increases bp(GO:"neuron projection maintenance") - pmid:30106381 + pubmed:27190210 - a(PUBCHEM:9832404) association bp(GO:"cell adhesion") + p(HGNC:HMOX1) decreases path(MESH:Inflammation) - pmid:30106381 + pubmed:28148553 - a(PUBCHEM:9832404) association bp(GO:"immune response") + p(HGNC:HMOX1) regulates bp(GO:"iron ion homeostasis") - pmid:30106381 + pubmed:29179999 - a(PUBCHEM:9832404) association path(MESH:"Autistic Disorder") + a(PUBCHEM:14193399) decreases a(CHEBI:"nitric oxide") - pmid:30106381 + pubmed:29179999 - a(PUBCHEM:9832404) decreases path(MESH:"Autistic Disorder") + a(PUBCHEM:14193399) decreases p(HGNC:TNF) - pmid:30106381 + pubmed:29179999 - a(PUBCHEM:9832404) association act(a(GO:synapse)) + a(PUBCHEM:14193399) decreases p(HGNC:IL1A) - pmid:30106381 + pubmed:29179999 - a(PUBCHEM:9832404) association bp(GO:"nervous system development") + a(PUBCHEM:14193399) decreases p(HGNC:PTGS2) - pmid:30106381 + pubmed:29179999 - a(PUBCHEM:9832404) association bp(GO:"synapse assembly") + a(PUBCHEM:14193399) decreases p(HGNC:NOS2) - pmid:30106381 + pubmed:29179999 - a(PUBCHEM:9832404) positiveCorrelation bp(GO:"synaptic transmission, glutamatergic") + a(PUBCHEM:14193399) decreases act(p(FPLX:NFkappaB)) - pmid:30106381 + pubmed:29179999 - a(PUBCHEM:9832404) regulates bp(GO:"synapse organization") + a(PUBCHEM:14193399) decreases act(p(HGNC:MAPK14)) - pmid:30106381 + pubmed:29179999 - a(PUBCHEM:9832404) regulates bp(GO:"cell communication") + a(PUBCHEM:14193399) decreases a(CHEBI:"reactive oxygen species") - pmid:30106381 + pubmed:29179999 - a(PUBCHEM:9832404) association bp(GO:"AMPA glutamate receptor clustering") + a(PUBCHEM:73078) decreases act(p(FPLX:NFkappaB)) - pmid:30106381 + pubmed:29179999 - a(PUBCHEM:9832404) association bp(GO:learning) + a(PUBCHEM:73078) decreases act(p(FPLX:NFkappaB)) - pmid:30106381 + pubmed:29179999 - a(PUBCHEM:9832404) association bp(GO:memory) + a(PUBCHEM:73078) decreases a(MESH:Cytokines) - pmid:30106381 + pubmed:29179999 - a(PUBCHEM:9832404) association bp(GO:"social behavior") + a(PUBCHEM:73078) decreases deg(p(HGNC:NFKBIA)) - pmid:30106381 + pubmed:29179999 - a(PUBCHEM:9832404) increases bp(GO:"social behavior") + a(PUBCHEM:73078) decreases tloc(p(HGNC:RELA), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) - pmid:30664622 + pubmed:29179999 - a(PUBCHEM:9832404) increases bp(GO:"social behavior") + a(PUBCHEM:73078) decreases act(p(HGNC:CHUK)) - pmid:30664622 + pubmed:29179999 - a(PUBCHEM:9832404) increases bp(GO:"social behavior") + a(PUBCHEM:73078) decreases act(p(HGNC:IKBKB)) - pmid:30106381 + pubmed:29179999 - a(PUBCHEM:9832404) regulates bp(GO:"ion transport") + a(PUBCHEM:73078) increases path(MESH:"Spatial Learning") - pmid:30106381 + pubmed:29179999 - a(PUBCHEM:9832404) association bp(GO:"vocalization behavior") + a(PUBCHEM:73078) increases bp(GO:memory) - pmid:30106381 + pubmed:29179999 - a(PUBCHEM:9832404) regulates complex(p(HGNC:ADNP), p(HGNC:AKT1)) + a(PUBCHEM:73078) decreases p(HGNC:IL1B) - pmid:30106381 + pubmed:29179999 - a(PUBCHEM:9832404) regulates complex(p(HGNC:ADNP), p(HGNC:DLG4)) + a(PUBCHEM:73078) decreases r(HGNC:TNF) - pmid:30106381 + pubmed:27288790 - a(PUBCHEM:9832404) increases p(HGNC:FPR3) + r(HGNC:TNF) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) - pmid:30106381 + pubmed:29179999 - a(PUBCHEM:9832404) decreases p(HGNC:TUBB1) + a(CHEBI:berberine) decreases path(MESH:Inflammation) - pmid:30106381 + pubmed:29179999 - a(PUBCHEM:9832404) association p(HGNC:APOE) + a(CHEBI:berberine) decreases p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation")) - pmid:30106381 + pubmed:29179999 - a(PUBCHEM:9832404) association g(HGNC:"IQCJ-SCHIP1") + a(CHEBI:berberine) decreases r(HGNC:RELA) - pmid:30106381 + pubmed:29179999 - a(PUBCHEM:9832404) association p(HGNC:NLGN2) + a(CHEBI:berberine) decreases p(HGNC:NFKBIA, pmod(go:0006468 ! "protein phosphorylation")) - pmid:30106381 + pubmed:29179999 - a(PUBCHEM:9832404) association p(HGNC:PAX6) + a(CHEBI:berberine) decreases act(p(HGNC:MAPK14)) - pmid:30106381 + pubmed:29179999 - a(PUBCHEM:9832404) regulates p(HGNC:WFS1) + a(CHEBI:berberine) decreases act(p(FPLX:ERK)) - pmid:30106381 + pubmed:29179999 - a(PUBCHEM:9832404) increases p(HGNC:HIST1H3B) + a(CHEBI:berberine) decreases act(p(FPLX:AKT)) - pmid:30106381 + pubmed:26551702 - a(PUBCHEM:9832404) decreases p(HGNC:ABCF3) + p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation")) regulates complex(a(MESH:DNA), p(HGNC:RELA)) - pmid:30106381 + pubmed:29179999 - a(PUBCHEM:9832404) decreases p(HGNC:BMP4) + a(CHEBI:oridonin) decreases act(p(FPLX:NFkappaB)) - pmid:30106381 + pubmed:29179999 - a(PUBCHEM:9832404) decreases p(HGNC:CDH17) + a(CHEBI:oridonin) increases bp(GO:cognition) - pmid:30106381 + pubmed:29179999 - a(PUBCHEM:9832404) decreases p(HGNC:KDM5D) + a(CHEBI:oridonin) decreases path(MESH:Inflammation) - pmid:30106381 + pubmed:29179999 - a(PUBCHEM:9832404) decreases p(HGNC:KLF1) + a(CHEBI:Anatabine) decreases act(p(FPLX:NFkappaB)) - pmid:30106381 + pubmed:22807490 - a(PUBCHEM:9832404) decreases p(HGNC:PER1) + a(CHEBI:Anatabine) decreases act(p(FPLX:NFkappaB)) - pmid:30106381 + pubmed:26010758 - a(PUBCHEM:9832404) decreases p(HGNC:AKT1) + a(CHEBI:Anatabine) decreases act(p(FPLX:NFkappaB)) - pmid:30106381 + pubmed:26010758 - a(PUBCHEM:9832404) decreases p(HGNC:AIF1) + a(CHEBI:Anatabine) decreases act(p(FPLX:NFkappaB)) - pmid:30106381 + pubmed:26010758 - a(PUBCHEM:9832404) regulates p(HGNC:MTOR) + a(CHEBI:Anatabine) decreases act(p(FPLX:NFkappaB)) - pmid:30106381 + pubmed:29179999 - a(PUBCHEM:9832404) increases path(MESH:"Psychomotor Performance") + a(CHEBI:Anatabine) decreases a(CHEBI:amyloid-beta) - pmid:30106381 + pubmed:21958873 - a(PUBCHEM:9832404) increases path(MESH:"Psychomotor Performance") + a(CHEBI:Anatabine) decreases a(CHEBI:amyloid-beta) - pmid:30106381 + pubmed:21958873 - a(PUBCHEM:9832404) decreases path(MESH:"Vestibular Diseases") + a(CHEBI:Anatabine) decreases a(CHEBI:amyloid-beta) - pmid:30106381 + pubmed:26010758 - a(PUBCHEM:9832404) increases path(MESH:"Motor Activity") + a(CHEBI:Anatabine) decreases a(CHEBI:amyloid-beta) - pmid:30106381 + pubmed:29179999 - a(PUBCHEM:9832404) increases bp(MESH:"Hand Strength") + a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 40") - pmid:30106381 + pubmed:21958873 - a(PUBCHEM:9832404) increases path(MESH:"Recognition (Psychology)") + a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 40") - pmid:30106381 + pubmed:21958873 - a(PUBCHEM:9832404) increases path(MESH:Smell) + a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 40") - pmid:30664622 + pubmed:21958873 - a(PUBCHEM:9832404) causesNoChange bp(GO:behavior) + a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 40") - pmid:30664622 + pubmed:29179999 - a(PUBCHEM:9832404) decreases path(MESH:"Motor Skills Disorders") + a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 42") - pmid:30664622 + pubmed:21958873 - a(PUBCHEM:9832404) decreases path(HBP:Excitotoxicity) + a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 42") - pmid:30664622 + pubmed:21958873 - act(a(PUBCHEM:9832404)) association a(GO:"glutamatergic synapse") + a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 42") - pmid:30664622 + pubmed:21958873 - a(PUBCHEM:9832404) causesNoChange p(HGNC:SLC17A7) + a(CHEBI:Anatabine) decreases a(CHEBI:"amyloid-beta polypeptide 42") - pmid:30664622 + pubmed:22807490 - a(PUBCHEM:9832404) causesNoChange p(HGNC:SLC17A7) + a(CHEBI:Anatabine) decreases bp(GO:"inflammatory response") - pmid:30664622 + pubmed:21958873 - a(PUBCHEM:9832404) increases p(HGNC:SLC17A7) + a(CHEBI:Anatabine) negativeCorrelation bp(GO:"inflammatory response") - pmid:30664622 + pubmed:23178521 - a(PUBCHEM:9832404) increases r(HGNC:SLC17A7) + a(CHEBI:Anatabine) negativeCorrelation bp(GO:"inflammatory response") - pmid:30664622 + pubmed:26010758 - a(PUBCHEM:9832404) decreases r(HGNC:SLC17A7) + a(CHEBI:Anatabine) decreases bp(GO:"inflammatory response") - pmid:30008470 + pubmed:26010758 - a(PUBCHEM:9832404) increases complex(a(GO:microtubule), p(HGNC:ADNP)) + a(CHEBI:Anatabine) decreases bp(GO:"inflammatory response") - pmid:30008470 + pubmed:26010758 - a(PUBCHEM:9832404) increases act(p(HGNC:ADNP)) + a(CHEBI:Anatabine) decreases bp(GO:"inflammatory response") - pmid:30061532 + pubmed:22807490 - a(MESH:"Antipsychotic Agents") decreases path(MESH:Schizophrenia) + a(CHEBI:Anatabine) decreases path(MESH:"Thyroiditis, Autoimmune") - pmid:30061532 + pubmed:22807490 - a(MESH:"Antipsychotic Agents") decreases path(MESH:"Psychotic Disorders") + a(CHEBI:Anatabine) decreases a(MESH:Thyroglobulin) - pmid:24590577 + pubmed:22807490 - a(MESH:"Antipsychotic Agents") association a(MESH:"4-(3-(4-butylpiperidin-1-yl)propyl)-7-fluoro-4H-benzo(1,4)oxazin-3-one") + a(CHEBI:Anatabine) decreases p(HGNC:IL1R2) - pmid:30061532 + pubmed:22807490 - a(PUBCHEM:3396) increases bp(GO:autophagy) + a(CHEBI:Anatabine) decreases p(HGNC:IL18) - pmid:30061532 + pubmed:22807490 - a(CHEBI:trifluoperazine) increases bp(GO:autophagy) + a(CHEBI:Anatabine) decreases p(HGNC:NOS2) - pmid:30061532 + pubmed:22807490 - a(CHEBI:pimozide) increases bp(GO:autophagy) + a(CHEBI:Anatabine) decreases p(HGNC:PTGS2) - pmid:30061532 + pubmed:22807490 - a(CHEBI:pimozide) increases bp(GO:autophagy) + a(CHEBI:Anatabine) decreases bp(GO:"macrophage activation") - pmid:30061532 + pubmed:21958873 - a(CHEBI:pimozide) increases act(p(HGNC:PRKAA1)) + a(CHEBI:Anatabine) causesNoChange tloc(p(HGNC:LDHA), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:30061532 + pubmed:21958873 - a(CHEBI:pimozide) decreases p(MGI:Mapt, pmod(Ph)) + a(CHEBI:Anatabine) decreases tloc(p(CONSO:sAPP-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:30061532 + pubmed:21958873 - act(p(HGNC:PRKAA1)) increases p(HGNC:ULK1, pmod(Ph)) + a(CHEBI:Anatabine) causesNoChange tloc(p(CONSO:sAPP-alpha), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - - - pmid:21722302 + pubmed:21958873 - p(HGNC:PRKAA1) negativeCorrelation p(HGNC:MTOR) + a(CHEBI:Anatabine) decreases act(complex(GO:"NF-kappaB complex")) - pmid:21722302 + pubmed:21958873 - p(HGNC:PRKAA1) regulates p(HGNCGENEFAMILY:"TSC complex") + a(CHEBI:Anatabine) decreases act(complex(GO:"NF-kappaB complex")) - pmid:29758300 + pubmed:21958873 - p(HGNC:PRKAA1) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + a(CHEBI:Anatabine) decreases act(complex(GO:"NF-kappaB complex")) - pmid:30061532 + pubmed:21958873 - p(HGNC:ULK1, pmod(Ph)) increases bp(GO:autophagy) + a(CHEBI:Anatabine) decreases act(complex(GO:"NF-kappaB complex")) - pmid:30061532 + pubmed:21958873 - a(CHEBI:chlorpromazine) increases bp(GO:autophagy) + a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation")) - pmid:30061532 + pubmed:23178521 - a(CHEBI:chlorpromazine) decreases bp(GO:"protein kinase B signaling") + a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation")) - pmid:30061532 + pubmed:23178521 - a(CHEBI:chlorpromazine) decreases act(p(HGNC:MTOR)) + a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation")) - pmid:23038257 + pubmed:23178521 - a(CHEBI:chlorpromazine) association complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) + a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation")) - pmid:23038257 + pubmed:23178521 - a(CHEBI:chlorpromazine) association p(HGNC:SCNN1D) + a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation")) - pmid:30061532 + pubmed:23178521 - a(CHEBI:sertindole) increases bp(GO:autophagy) + a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation")) - pmid:30061532 + pubmed:23178521 - a(CHEBI:clozapine) increases bp(GO:autophagy) + a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation")) - pmid:30061532 + pubmed:23178521 - a(CHEBI:clozapine) increases bp(GO:autophagy) + a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation")) - pmid:30061532 + pubmed:23178521 - a(CHEBI:clozapine) increases p(HGNC:PRKAA1, pmod(Ph)) + a(CHEBI:Anatabine) decreases p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation")) - pmid:30061532 + pubmed:21958873 - a(CHEBI:clozapine) increases p(HGNC:ULK1, pmod(Ph)) + a(CHEBI:Anatabine) decreases r(HGNC:BACE1) - pmid:30061532 + pubmed:26010758 - a(CHEBI:clozapine) increases p(HGNC:BECN1, pmod(Ph)) + a(CHEBI:Anatabine) decreases r(HGNC:BACE1) - pmid:30061532 + pubmed:21958873 - a(CHEBI:clozapine) increases a(GO:autophagosome) + a(CHEBI:Anatabine) decreases p(HGNC:BACE1) - pmid:30061532 + pubmed:21958873 - a(CHEBI:clozapine) decreases a(CHEBI:"amyloid-beta") + a(CHEBI:Anatabine) decreases bp(GO:"amyloid-beta formation") - pmid:19721446 + pubmed:21958873 - a(CHEBI:clozapine) increases bp(MESH:"Sensory Gating") + a(CHEBI:Anatabine) decreases p(HGNC:CRP) - pmid:19721446 + pubmed:23178521 - a(CHEBI:clozapine) association p(HGNC:CHRNA7) + a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(go:0006468 ! "protein phosphorylation")) - pmid:30116051 + pubmed:23178521 - p(HGNC:BECN1, pmod(Ph)) increases act(p(HGNC:BECN1)) + a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(go:0006468 ! "protein phosphorylation")) - pmid:21722302 + pubmed:23178521 - a(GO:autophagosome) association path(MESH:"Alzheimer Disease") + a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(go:0006468 ! "protein phosphorylation")) - pmid:22908190 + pubmed:23178521 - a(GO:autophagosome) positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(go:0006468 ! "protein phosphorylation")) - pmid:18930136 + pubmed:23178521 - a(GO:autophagosome) positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(go:0006468 ! "protein phosphorylation")) - pmid:18930136 + pubmed:23178521 - a(GO:autophagosome) positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(go:0006468 ! "protein phosphorylation")) - pmid:22908190 + pubmed:23178521 - a(GO:autophagosome) association a(HBP:"dystrophic neurite") + a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(go:0006468 ! "protein phosphorylation")) - pmid:22908190 + pubmed:23178521 - a(GO:autophagosome) increases a(GO:organelle) + a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(go:0006468 ! "protein phosphorylation")) - pmid:22908190 + pubmed:26010758 - a(GO:autophagosome) association p(HGNC:APP) + a(CHEBI:Anatabine) decreases p(HGNC:STAT3, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + - pmid:18930136 + pubmed:23178521 - a(GO:autophagosome) increases bp(GO:autophagy) + a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(go:0006468 ! "protein phosphorylation")) - pmid:18930136 + pubmed:23178521 - a(GO:autophagosome) increases bp(GO:"autophagosome-lysosome fusion") + a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(go:0006468 ! "protein phosphorylation")) - pmid:18930136 + pubmed:23383175 - a(GO:autophagosome) increases complex(a(GO:"multivesicular body"), a(GO:autophagosome), a(GO:endosome)) + a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(go:0006468 ! "protein phosphorylation")) - pmid:18930136 + pubmed:23383175 - a(GO:autophagosome) association complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:MAP1LC3B)) + a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(go:0006468 ! "protein phosphorylation")) - pmid:18930136 + pubmed:23383175 - a(GO:autophagosome) positiveCorrelation path(MESH:"Parkinson Disease") + a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(go:0006468 ! "protein phosphorylation")) - pmid:18930136 + pubmed:23383175 - a(GO:autophagosome) positiveCorrelation path(MESH:"Creutzfeldt-Jakob Syndrome") + a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(go:0006468 ! "protein phosphorylation")) - pmid:18930136 + pubmed:23383175 - a(GO:autophagosome) negativeCorrelation p(HGNC:CTSD) + a(CHEBI:Anatabine) decreases p(MGI:Stat3, pmod(go:0006468 ! "protein phosphorylation")) - pmid:18930136 + pubmed:23178521 - a(GO:autophagosome) positiveCorrelation p(HGNC:DCTN1, var("?")) + a(CHEBI:Anatabine) decreases p(MGI:Tnf) - pmid:24027553 + pubmed:23383175 - p(MGI:Mapt, pmod(Ph)) increases path(HBP:Neurodegeneration) + a(CHEBI:Anatabine) causesNoChange p(MGI:Tnf) - pmid:30126037 + pubmed:23383175 - p(MGI:Mapt, pmod(Ph)) causesNoChange p(MGI:Cdkn2a) + a(CHEBI:Anatabine) decreases p(MGI:Tnf) - pmid:19491104 + pubmed:23178521 - p(MGI:Mapt, pmod(Ph)) association p(MGI:Mapk8ip1) + a(CHEBI:Anatabine) decreases p(MGI:Il6) - pmid:19491104 + pubmed:23383175 - p(MGI:Mapt, pmod(Ph)) negativeCorrelation act(p(MGI:Mapk8ip1)) + a(CHEBI:Anatabine) decreases p(MGI:Il6) - pmid:19491104 + pubmed:23383175 - p(MGI:Mapt, pmod(Ph)) negativeCorrelation act(p(MGI:Klc1)) + a(CHEBI:Anatabine) decreases a(MESH:Cytokines) - pmid:28173111 + pubmed:23383175 - p(MGI:Mapt, pmod(Ph)) positiveCorrelation r(MGI:Dnm1l) + a(CHEBI:Anatabine) increases bp(GO:"neuroinflammatory response") - - - - - - - - - pmid:29024336 + pubmed:23383175 - p(MGI:Mapt) decreases bp(GO:"late endosomal microautophagy") + a(CHEBI:Anatabine) negativeCorrelation path(MESH:Encephalomyelitis) - - - - - - - - - - - - - - - pmid:29202785 + pubmed:23383175 - p(MGI:Mapt) increases bp(GO:"neuron migration") + a(CHEBI:Anatabine) decreases path(MESH:Encephalomyelitis) - pmid:29202785 + pubmed:23383175 - p(MGI:Mapt) increases bp(GO:"neuron differentiation") + a(CHEBI:Anatabine) decreases path(MESH:Paralysis) - pmid:29202785 + doi:"10.4172/2168-975X.1000126" - p(MGI:Mapt) increases bp(GO:"neuron maturation") + a(CHEBI:Anatabine) decreases path(MESH:Paralysis) - - - - - - - pmid:30126037 + pubmed:23383175 - p(MGI:Mapt) increases a(GO:"neurofibrillary tangle") + a(CHEBI:Anatabine) decreases path(HP:"Limb muscle weakness") - pmid:30126037 + pubmed:23383175 - p(MGI:Mapt) increases bp(HP:Neurodegeneration) + a(CHEBI:Anatabine) decreases p(MGI:Il1b) - pmid:30126037 + pubmed:23383175 - p(MGI:Mapt) increases p(MGI:Cdkn2a) + a(CHEBI:Anatabine) decreases p(MGI:Il1b) - pmid:30126037 + pubmed:23383175 - p(MGI:Mapt) increases bp(GO:"cellular senescence") + a(CHEBI:Anatabine) decreases p(MGI:Il17a) - pmid:30126037 + pubmed:23383175 - p(MGI:Mapt) increases path(HP:"Brain atrophy") + a(CHEBI:Anatabine) decreases p(MGI:Il17a) - - - - - pmid:28408124 + pubmed:23383175 - tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) increases a(HBP:"Tau aggregates") + a(CHEBI:Anatabine) causesNoChange p(MGI:Ifng) - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - pmid:18096814 + pubmed:23383175 - p(MGI:Mapt) negativeCorrelation a(CHEBI:"2-bromohexadecanoic acid") + a(CHEBI:Anatabine) decreases p(MGI:Ifng) - - - - - - - pmid:19118186 + pubmed:23383175 - p(MGI:Mapt) negativeCorrelation bp(GO:memory) + a(CHEBI:Anatabine) decreases p(MGI:Rela, pmod(go:0006468 ! "protein phosphorylation")) - pmid:29221819 + pubmed:23383175 - p(MGI:Mapt) positiveCorrelation p(MGI:Dyrk1a) + a(CHEBI:Anatabine) decreases p(MGI:Rela, pmod(go:0006468 ! "protein phosphorylation")) - pmid:28877763 + pubmed:23383175 - p(MGI:Mapt) positiveCorrelation p(MGI:Syk) + a(CHEBI:Anatabine) causesNoChange bp(CONSO:Astrogliosis) - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - pmid:30061532 + pubmed:23383175 - a(CHEBI:haloperidol) decreases a(HBP:"huntingtin aggregates") + a(CHEBI:Anatabine) decreases bp(CONSO:Astrogliosis) - pmid:24706768 + pubmed:23383175 - a(HBP:"huntingtin aggregates") decreases bp(GO:"clathrin-dependent endocytosis") + a(CHEBI:Anatabine) decreases bp(CONSO:Microgliosis) - pmid:24706768 + doi:"10.4172/2168-975X.1000126" - a(HBP:"huntingtin aggregates") decreases bp(GO:"clathrin-dependent endocytosis") + a(CHEBI:Anatabine) decreases bp(CONSO:Microgliosis) - pmid:19126755 + pubmed:23383175 - act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) regulates p(FPLX:PLC) + a(CHEBI:Anatabine) decreases tloc(a(MESH:Leukocytes), fromLoc(GO:"extracellular region"), toLoc(MESH:"Spinal Cord")) - pmid:19126755 + pubmed:23383175 - act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) regulates a(CHEBI:"3',5'-cyclic AMP") + a(CHEBI:Anatabine) decreases a(MESH:Microglia) - pmid:19126755 + pubmed:23383175 - act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) regulates a(CHEBI:"myo-inositol trisphosphate") + a(CHEBI:Anatabine) decreases tloc(a(MESH:Microglia), fromLoc(GO:"extracellular region"), toLoc(MESH:"Spinal Cord")) - pmid:19126755 + pubmed:23383175 - act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) regulates a(CHEBI:"calcium ion") + a(CHEBI:Anatabine) decreases tloc(a(MESH:Macrophages), fromLoc(GO:"extracellular region"), toLoc(MESH:"Spinal Cord")) - pmid:24511233 + pubmed:23383175 - p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") regulates act(a(CHEBI:acetylcholine)) + a(CHEBI:Anatabine) positiveCorrelation a(GO:"myelin sheath") - pmid:19721446 + doi:"10.4172/2168-975X.1000126" - p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") increases act(a(CHEBI:acetylcholine)) + a(CHEBI:Anatabine) increases bp(GO:"motor behavior") - + + + doi:"10.4172/2168-975X.1000126" + + a(CHEBI:Anatabine) increases bp(GO:"motor behavior") + - + + + doi:"10.4172/2168-975X.1000126" + + a(CHEBI:Anatabine) decreases path(MESH:Anxiety) + + + + pubmed:26010758 + + a(CHEBI:Anatabine) decreases path(MESH:Anxiety) + + - pmid:24511233 + doi:"10.4172/2168-975X.1000126" - p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") isA p(MESH:"Receptors, G-Protein-Coupled") + a(CHEBI:Anatabine) causesNoChange path(MESH:"Spatial Learning") - pmid:24511233 + doi:"10.4172/2168-975X.1000126" - p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") regulates bp(GO:cognition) + a(CHEBI:Anatabine) causesNoChange p(HGNC:MAPT) - pmid:24590577 + doi:"10.4172/2168-975X.1000126" - p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association path(MESH:"Alzheimer Disease") + a(CHEBI:Anatabine) decreases act(p(HGNC:MAPT)) - pmid:24590577 + doi:"10.4172/2168-975X.1000126" - p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association bp(GO:memory) + a(CHEBI:Anatabine) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396), pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) - pmid:24590577 + doi:"10.4172/2168-975X.1000126" - p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association path(MESH:Attention) + a(CHEBI:Anatabine) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) - pmid:24590577 + doi:"10.4172/2168-975X.1000126" - p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association path(MESH:Nociception) + a(CHEBI:Anatabine) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) - pmid:24590577 + doi:"10.4172/2168-975X.1000126" - p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association bp(GO:"circadian sleep/wake cycle") + a(CHEBI:Anatabine) decreases a(GO:"neurofibrillary tangle") - pmid:24590577 + doi:"10.4172/2168-975X.1000126" - p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association a(MESH:"Cardiovascular System") + a(CHEBI:Anatabine) decreases a(CONSO:"Tau oligomers") - pmid:24590577 + doi:"10.4172/2168-975X.1000126" - p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association a(MESH:Kidney) + a(CHEBI:Anatabine) decreases a(CONSO:"Tau oligomers") - pmid:24590577 + doi:"10.4172/2168-975X.1000126" - p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association a(MESH:"Gastrointestinal Tract") + a(CHEBI:Anatabine) increases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) - pmid:19126755 + doi:"10.4172/2168-975X.1000126" - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Electric Fish") + a(CHEBI:Anatabine) increases p(FPLX:AKT, pmod(go:0006468 ! "protein phosphorylation", Ser, 473)) @@ -59562,4982 +59962,5244 @@

Statements

- pmid:19126755 + pubmed:26010758 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") increases sec(a(CHEBI:"gamma-aminobutyric acid")) + a(CHEBI:Anatabine) decreases path(MESH:Gliosis) - pmid:19721446 + pubmed:26010758 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases sec(a(CHEBI:"gamma-aminobutyric acid")) + a(CHEBI:Anatabine) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:19126755 + pubmed:26010758 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) regulates bp(GO:"synaptic transmission, dopaminergic") + a(CHEBI:Anatabine) increases act(p(HGNC:CHRNA7)) - pmid:19126755 + pubmed:26010758 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) negativeCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:Anatabine) decreases act(p(HGNC:STAT3)) - pmid:19126755 + pubmed:26010758 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") negativeCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:Anatabine) decreases act(p(HGNC:STAT3)) - pmid:19126755 + pubmed:26010758 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:Anatabine) decreases act(p(HGNC:STAT3)) - pmid:19293145 + pubmed:26010758 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association path(MESH:"Alzheimer Disease") + a(CHEBI:Anatabine) decreases bp(GO:locomotion) - pmid:19126755 + pubmed:26010758 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) negativeCorrelation path(MESH:Schizophrenia) + a(CHEBI:Anatabine) increases path(MESH:"Interpersonal Relations") - pmid:19126755 + pubmed:26010758 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) negativeCorrelation a(CHEBI:"kynurenic acid") + a(CHEBI:Anatabine) decreases p(HGNC:AIF1) - pmid:19126755 + pubmed:26010758 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association a(CHEBI:"amyloid-beta polypeptide 42") + a(CHEBI:Anatabine) decreases bp(GO:"microglial cell activation") - pmid:19126755 + pubmed:26010758 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association a(CHEBI:anandamide) + a(CHEBI:Anatabine) decreases p(HGNC:PTPRC) - pmid:19126755 + pubmed:26010758 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(CHEBI:anandamide) + a(CHEBI:Anatabine) decreases p(FPLX:NFkappaB, pmod(go:0006468 ! "protein phosphorylation", Ser, 536)) - pmid:19126755 + pubmed:26010758 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases bp(GO:"cation transport") + a(CHEBI:Anatabine) decreases r(HGNC:PTGS2) - pmid:19126755 + pubmed:26010758 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases a(MESH:Sodium, loc(GO:intracellular)) + a(CHEBI:Anatabine) decreases r(HGNC:NOS2) - pmid:19126755 + pubmed:29844403 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases bp(GO:"membrane depolarization") + a(CHEBI:"amyloid-beta polypeptide 40") decreases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) - pmid:19126755 + pubmed:29844403 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases bp(GO:"positive regulation of voltage-gated calcium channel activity") + a(CHEBI:"amyloid-beta polypeptide 40") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) + + + + + + - pmid:19126755 + pubmed:25514383 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases a(CHEBI:"calcium(2+)", loc(GO:intracellular)) + a(CHEBI:"amyloid-beta polypeptide 40") decreases act(p(CONSO:"alpha-4 beta-2 nAChR")) - pmid:19126755 + pubmed:25514383 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") regulates bp(GO:"inflammatory response") + a(CHEBI:"amyloid-beta polypeptide 40") decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) - pmid:19126755 + pubmed:14556719 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) decreases bp(GO:"keratinocyte migration") + a(CHEBI:"amyloid-beta polypeptide 40") increases a(CONSO:"amyloid-beta fibrils") - pmid:19126755 + pubmed:26195256 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) regulates bp(GO:"phosphatidylinositol 3-kinase signaling") + a(CHEBI:"amyloid-beta polypeptide 40") isA a(CHEBI:amyloid-beta) - pmid:19126755 + pubmed:29179999 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) regulates bp(GO:"ERK1 and ERK2 cascade") + a(CHEBI:"vitamin D") decreases p(FPLX:NFkappaB, pmod(go:0006468 ! "protein phosphorylation")) - pmid:19126755 + pubmed:29179999 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) regulates bp(GO:"receptor signaling pathway via JAK-STAT") + a(CHEBI:"vitamin D") decreases a(CHEBI:"reactive oxygen species") - pmid:19126755 + pubmed:29179999 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Mice, Inbred Strains") + a(CHEBI:"vitamin D") decreases path(MESH:Inflammation) - pmid:19126755 + pubmed:26445701 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Mice, Inbred Strains") + a(CHEBI:"vitamin D") decreases path(DOID:"multiple sclerosis") - pmid:19126755 + pubmed:26445701 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Rats, Inbred Strains") + a(CHEBI:"vitamin D") regulates bp(MESH:Immunity) - pmid:19126755 + pubmed:29179999 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") negativeCorrelation path(MESH:Aging) + a(CHEBI:alpha-tocopherol) decreases a(CHEBI:"reactive oxygen species") - pmid:19293145 + pubmed:29179999 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(CHEBI:"amyloid-beta") + a(CHEBI:alpha-tocopherol) decreases a(CHEBI:amyloid-beta) - pmid:19293145 + pubmed:29179999 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(CHEBI:"amyloid-beta") + a(CHEBI:alpha-tocopherol) decreases a(CHEBI:amyloid-beta) - pmid:19293145 + pubmed:29179999 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") regulates sec(a(CHEBI:"amyloid-beta")) + a(CHEBI:alpha-tocopherol) decreases a(MESH:Cytokines) - pmid:19293145 + pubmed:29179999 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") regulates act(a(CHEBI:"amyloid-beta")) + a(CHEBI:alpha-tocopherol) decreases a(CHEBI:"nitric oxide") - pmid:19293145 + pubmed:29179999 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association a(CHEBI:"amyloid-beta") + a(CHEBI:alpha-tocopherol) increases bp(GO:memory) - pmid:19293145 + pubmed:29179999 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") decreases path(HBP:neurotoxicity) + a(CHEBI:alpha-tocopherol) decreases path(MESH:"Oxidative Stress") - pmid:19293145 + pubmed:29179999 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association path(HBP:neurotoxicity) + a(CHEBI:alpha-tocopherol) decreases act(p(FPLX:NFkappaB)) - pmid:19293145 + pubmed:29179999 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(CHEBI:nicotine) + a(CHEBI:alpha-tocopherol) decreases p(HGNC:NOS2) - pmid:19293145 + pubmed:29179999 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) decreases act(a(CHEBI:"N-methyl-4-phenylpyridinium")) + a(CHEBI:alpha-tocopherol) decreases p(HGNC:IL6) - pmid:19293145 + pubmed:29179999 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") increases bp(MESH:Neuroprotection) + a(CHEBI:alpha-tocopherol) decreases p(HGNC:IL1B) - pmid:19293145 + pubmed:29179999 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases act(p(FPLX:PI3K)) + a(CHEBI:alpha-tocopherol) decreases bp(GO:"microglial cell activation") - pmid:19293145 + pubmed:14970312 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association p(HGNC:JAK2) + a(CHEBI:alpha-tocopherol) decreases bp(GO:"regulation of sphingomyelin catabolic process") - pmid:19293145 + pubmed:27794524 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association bp(GO:"calcium ion homeostasis") + bp(GO:"microglial cell activation") association path(MESH:"Nerve Degeneration") - pmid:19293145 + pubmed:27794524 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association g(HGNC:APOE) + bp(GO:"microglial cell activation") association path(MESH:"Demyelinating Diseases") - pmid:19293145 + pubmed:27794524 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association p(HGNC:APOE) + bp(GO:"microglial cell activation") directlyIncreases a(MESH:Macrophages) - pmid:19293145 + pubmed:27794524 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases sec(a(HBP:"sAPP-beta")) + bp(GO:"microglial cell activation") decreases bp(GO:"compartment boundary maintenance") - pmid:19293145 + pubmed:27794524 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association bp(GO:"apoptotic process") + bp(GO:"microglial cell activation") association path(MESH:Inflammation) - pmid:19293145 + pubmed:27956442 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) decreases p(HGNC:MAPT, pmod(Ph)) + bp(GO:"microglial cell activation") directlyIncreases path(MESH:Inflammation) - pmid:24511233 + pubmed:26979166 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") regulates act(a(CHEBI:acetylcholine)) + bp(GO:"microglial cell activation") increases path(MESH:Inflammation) - pmid:19721446 + pubmed:27794524 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") increases act(a(CHEBI:acetylcholine)) + bp(GO:"microglial cell activation") association path(MESH:"Autoimmune Diseases") - pmid:19721446 + pubmed:27794524 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Peripheral Nervous System") + bp(GO:"microglial cell activation") decreases a(MESH:Oligodendroglia) - pmid:19721446 + pubmed:27794524 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Central Nervous System") + bp(GO:"microglial cell activation") increases tloc(p(HGNC:IL1A), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:19721446 + pubmed:27794524 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases sec(a(CHEBI:dopamine)) + bp(GO:"microglial cell activation") increases tloc(p(HGNC:IL6), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:19721446 + pubmed:27314526 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases sec(a(CHEBI:serotonin)) + bp(GO:"microglial cell activation") increases tloc(p(HGNC:IL6), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:19721446 + pubmed:27794524 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases sec(a(CHEBI:"glutamate(2-)")) + bp(GO:"microglial cell activation") increases tloc(p(HGNC:TNF), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:19721446 + pubmed:30967783 - act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association a(CHEBI:cholesterol) + bp(GO:"microglial cell activation") increases p(HGNC:TNF) - pmid:19721446 + pubmed:27794524 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") regulates bp(MESH:"Sensory Gating") + bp(GO:"microglial cell activation") increases tloc(p(HGNC:IFNG), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:19126755 + pubmed:27794524 - a(CHEBI:Muscarine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) + bp(GO:"microglial cell activation") increases act(a(MESH:Phagocytes)) - pmid:19126755 + pubmed:27794524 - a(CHEBI:atropine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) + bp(GO:"microglial cell activation") positiveCorrelation bp(GO:"regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II") - pmid:19126755 + pubmed:27794524 - a(CHEBI:atropine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) + bp(GO:"microglial cell activation") increases path(MESH:Neuroprotection) - pmid:19126755 + pubmed:27794524 - a(CHEBI:atropine) decreases bp(GO:"cell adhesion") + bp(GO:"microglial cell activation") increases path(MESH:Phagocytosis) - pmid:26813123 + pubmed:27794524 - a(CHEBI:atropine) decreases act(p(FPLX:CHRM)) + bp(GO:"microglial cell activation") increases bp(GO:"neuron remodeling") - pmid:26751493 + pubmed:27794524 - p(FPLX:PLC) association p(HBP:"projection domain") + bp(GO:"microglial cell activation") increases bp(GO:"monocyte migration into blood stream") - pmid:29626319 + pubmed:27794524 - a(CHEBI:"3',5'-cyclic AMP") increases deg(p(HGNC:MAPT)) + bp(GO:"microglial cell activation") increases path(MESH:"Neurodegenerative Diseases") - pmid:29758300 + pubmed:30967783 - a(CHEBI:"calcium ion") increases act(a(MESH:"Vacuolar Proton-Translocating ATPases")) + bp(GO:"microglial cell activation") increases composite(a(MESH:Microglia), a(MESH:Neurons)) - pmid:19126755 + pubmed:30967783 - a(CHEBI:nicotine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + bp(GO:"microglial cell activation") increases bp(GO:"complement activation") - pmid:19126755 + pubmed:30967783 - a(CHEBI:nicotine) decreases deg(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits", loc(GO:"endoplasmic reticulum"))) + bp(GO:"microglial cell activation") increases tloc(a(MESH:Chemokines), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:19126755 + pubmed:26979166 - a(CHEBI:nicotine) increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + bp(GO:"microglial cell activation") increases tloc(a(MESH:Chemokines), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:19126755 + pubmed:30967783 - a(CHEBI:nicotine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + bp(GO:"microglial cell activation") increases tloc(a(MESH:Cytokines), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:19126755 + pubmed:30967783 - a(CHEBI:nicotine) causesNoChange p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + bp(GO:"microglial cell activation") increases a(MESH:Cytokines) - pmid:19126755 + pubmed:26979166 - a(CHEBI:nicotine) regulates p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + bp(GO:"microglial cell activation") increases tloc(a(MESH:Cytokines), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:19126755 + pubmed:30967783 - a(CHEBI:nicotine) regulates act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + bp(GO:"microglial cell activation") increases bp(GO:"excitatory postsynaptic potential") - pmid:19293145 + pubmed:30967783 - a(CHEBI:nicotine) association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + bp(GO:"microglial cell activation") increases tloc(a(CHEBI:"2 L-glutamate"), fromLoc(MESH:Astrocytes), toLoc(MESH:Synapses)) - pmid:19293145 + pubmed:30967783 - a(CHEBI:nicotine) increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + bp(GO:"microglial cell activation") increases a(MESH:"Reactive Oxygen Species") - pmid:19721446 + pubmed:26979166 - a(CHEBI:nicotine) increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + bp(GO:"microglial cell activation") increases tloc(a(MESH:"Reactive Oxygen Species"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:19721446 + pubmed:30967783 - act(a(CHEBI:nicotine)) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + bp(GO:"microglial cell activation") increases a(MESH:"Reactive Nitrogen Species") - pmid:19126755 + pubmed:30967783 - a(CHEBI:nicotine) causesNoChange a(MESH:Manduca) + bp(GO:"microglial cell activation") causesNoChange bp(GO:"T cell activation") - pmid:19126755 + pubmed:30967783 - a(CHEBI:nicotine) association path(HBP:neurotoxicity) + bp(GO:"microglial cell activation") increases bp(MESH:Remyelination) - pmid:19293145 + pubmed:30967783 - a(CHEBI:nicotine) decreases path(HBP:neurotoxicity) + bp(GO:"microglial cell activation") increases bp(GO:phagocytosis) - pmid:19126755 + pubmed:30988501 - a(CHEBI:nicotine) increases p(HBP:"alpha-4 beta-2 nAChR") + bp(GO:"microglial cell activation") increases bp(GO:phagocytosis) - pmid:19126755 + pubmed:30988501 - a(CHEBI:nicotine) increases p(HBP:"alpha-4 beta-2 nAChR") + bp(GO:"microglial cell activation") increases bp(GO:phagocytosis) - pmid:19126755 + pubmed:30988501 - a(CHEBI:nicotine) increases p(HBP:"alpha-4 beta-2 nAChR") + bp(GO:"microglial cell activation") increases bp(GO:phagocytosis) - pmid:19126755 + pubmed:30967783 - a(CHEBI:nicotine) decreases act(p(HBP:"alpha-4 beta-2 nAChR")) + bp(GO:"microglial cell activation") directlyIncreases g(HGNC:PRSS3P2) - pmid:19126755 + pubmed:30967783 - a(CHEBI:nicotine) increases complex(a(CHEBI:nicotine), p(HBP:"alpha-4 beta-2 nAChR")) + bp(GO:"microglial cell activation") increases tloc(p(HGNC:IGF1), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:19126755 + pubmed:30967783 - a(CHEBI:nicotine) increases a(HBP:"alpha-3 beta-2 nAChR") + bp(GO:"microglial cell activation") increases tloc(p(MESH:"Fibroblast Growth Factors"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:18174175 + pubmed:30967783 - a(CHEBI:nicotine) increases a(HBP:"alpha-3 beta-2 nAChR") + bp(GO:"microglial cell activation") increases bp(GO:neurogenesis) - pmid:19126755 + pubmed:30967783 - a(CHEBI:nicotine) increases a(HBP:"alpha-3 beta-4 nAChR") + bp(GO:"microglial cell activation") increases p(HGNC:IL4) - pmid:19126755 + pubmed:30967783 - a(CHEBI:nicotine) decreases complex(p(HGNC:CHRNA6), p(HGNC:CHRNB3)) + bp(GO:"microglial cell activation") increases p(MESH:Activins) - pmid:19126755 + pubmed:30967783 - a(CHEBI:nicotine) increases act(p(FPLX:PI3K)) + bp(GO:"microglial cell activation") association a(DRUGBANK:"Ethyl pyruvate") - pmid:19293145 + pubmed:30967783 - a(CHEBI:nicotine) increases act(p(FPLX:PI3K)) + bp(GO:"microglial cell activation") association a(CHEBI:spermidine) - pmid:19126755 + pubmed:30967783 - a(CHEBI:nicotine) increases act(p(FPLX:PKA)) + bp(GO:"microglial cell activation") association a(CHEBI:"bryostatin 1") - pmid:19126755 + pubmed:30967783 - a(CHEBI:nicotine) increases act(p(FPLX:PKC)) + bp(GO:"microglial cell activation") association a(CHEBI:forskolin) - pmid:19126755 + pubmed:30967783 - a(CHEBI:nicotine) increases act(p(FPLX:"CAMK2_complex")) + bp(GO:"microglial cell activation") association a(DRUGBANK:Lenalidomide) - pmid:19126755 + pubmed:" 26517285" - act(a(CHEBI:nicotine)) increases act(p(FPLX:CREB), ma(tscript)) + bp(GO:"microglial cell activation") association bp(GO:"immune response") - pmid:19126755 + pubmed:" 26517285" - act(a(CHEBI:nicotine)) increases act(p(HGNC:ATF2), ma(tscript)) + bp(GO:"microglial cell activation") negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:19126755 + pubmed:" 26517285" - act(a(CHEBI:nicotine)) increases act(p(RGD:Elk1), ma(tscript)) + bp(GO:"microglial cell activation") association g(DBSNP:rs3824968) - pmid:19126755 + pubmed:20100581 - act(a(CHEBI:nicotine)) increases act(p(HGNC:STAT3), ma(tscript)) + bp(GO:"microglial cell activation") association bp(GO:"apoptotic process") - pmid:19293145 + pubmed:26836182 - act(a(CHEBI:nicotine)) association act(p(HGNC:STAT3)) + bp(GO:"microglial cell activation") positiveCorrelation path(CONSO:neuroinflammation) - pmid:19126755 + pubmed:26836182 - act(a(CHEBI:nicotine)) association a(MESH:Skin) + bp(GO:"microglial cell activation") increases p(HGNC:CHI3L1) - pmid:19126755 + pubmed:26979166 - act(a(CHEBI:nicotine)) regulates bp(GO:"inflammatory response") + bp(GO:"microglial cell activation") increases p(HGNC:CHI3L1) - pmid:23178521 + pubmed:21871088 - a(CHEBI:nicotine) regulates bp(GO:"inflammatory response") + bp(GO:"microglial cell activation") association a(NIFT:"Hippocampal atrophy") - pmid:19126755 + pubmed:21871088 - a(CHEBI:nicotine) decreases path(MESH:"Colitis, Ulcerative") + bp(GO:"microglial cell activation") association a(NIFT:"White matter lesion") - pmid:19126755 + pubmed:26979166 - a(CHEBI:nicotine) decreases path(MESH:"Inflammatory Bowel Diseases") + bp(GO:"microglial cell activation") decreases a(CHEBI:monoamine) - pmid:19126755 + pubmed:26979166 - a(CHEBI:nicotine) decreases sec(p(HGNC:TNF)) + bp(GO:"microglial cell activation") association path(HP:Psychosis) - pmid:19293145 + pubmed:26979166 - a(CHEBI:nicotine) regulates act(p(HGNC:TNF)) + bp(GO:"microglial cell activation") increases tloc(a(CHEBI:prostaglandin), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:19126755 + pubmed:26979166 - act(a(CHEBI:nicotine)) association path(MESH:"Genetic Variation") + bp(GO:"microglial cell activation") increases p(HGNC:IL1B) - pmid:19126755 + pubmed:27314526 - a(CHEBI:nicotine) causesNoChange path(MESH:"Alzheimer Disease") + bp(GO:"microglial cell activation") increases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:19126755 + pubmed:26979166 - a(CHEBI:nicotine) causesNoChange p(MGI:Chrna4) + bp(GO:"microglial cell activation") increases p(HGNC:IL1R1) - pmid:19126755 + pubmed:26979166 - a(CHEBI:nicotine) decreases act(a(CHEBI:"NS-398")) + bp(GO:"microglial cell activation") increases p(HGNC:MYD88) - pmid:19126755 + pubmed:26979166 - a(CHEBI:nicotine) decreases bp(GO:"neuron death") + bp(GO:"microglial cell activation") increases p(HGNC:NOS2) - pmid:19126755 + pubmed:27314526 - a(CHEBI:nicotine) decreases bp(GO:"neuron death") + bp(GO:"microglial cell activation") increases tloc(p(HGNC:NOS2), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:19126755 + pubmed:26979166 - a(CHEBI:nicotine) increases sec(a(CHEBI:dopamine)) + bp(GO:"microglial cell activation") increases p(HGNC:CCL2) - pmid:17009926 + pubmed:26979166 - a(CHEBI:nicotine) decreases sec(a(CHEBI:dopamine)) + bp(GO:"microglial cell activation") positiveCorrelation path(MESH:Depression) - pmid:21482353 + pubmed:26979166 - a(CHEBI:nicotine) decreases a(CHEBI:dopamine) + bp(GO:"microglial cell activation") increases deg(a(CHEBI:amyloid-beta)) - pmid:21482353 + pubmed:21718217 - a(CHEBI:nicotine) increases tloc(a(CHEBI:dopamine), fromLoc(MESH:"Presynaptic Terminals"), toLoc(GO:"extracellular region")) + bp(GO:"microglial cell activation") association a(CONSO:CONSO00089) - pmid:19721446 + pubmed:21718217 - a(CHEBI:nicotine) regulates sec(a(CHEBI:dopamine)) + bp(GO:"microglial cell activation") positiveCorrelation a(CONSO:CONSO00089) - pmid:28391535 + pubmed:30106381 - a(CHEBI:nicotine) increases sec(a(CHEBI:dopamine)) + bp(GO:"microglial cell activation") association p(HGNC:AIF1) - pmid:28391535 + pubmed:26010758 - a(CHEBI:nicotine) increases act(a(CHEBI:dopamine)) + bp(GO:"microglial cell activation") positiveCorrelation p(HGNC:AIF1) - pmid:19126755 + pubmed:27209302 - a(CHEBI:nicotine) increases path(MESH:"Behavior, Addictive") + bp(GO:"microglial cell activation") increases deg(p(CONSO:"amyloid-beta oligomers")) - pmid:19126755 + pubmed:27209302 - a(CHEBI:nicotine) increases path(MESH:Craving) + bp(GO:"microglial cell activation") increases deg(p(CONSO:"amyloid-beta oligomers")) - pmid:19126755 + pubmed:27209302 - a(CHEBI:nicotine) increases path(MESH:Anxiety) + bp(GO:"microglial cell activation") increases deg(p(CONSO:"amyloid-beta fibrils")) - pmid:19126755 + pubmed:27209302 - a(CHEBI:nicotine) association act(p(HGNC:CHRNA7)) + bp(GO:"microglial cell activation") increases deg(p(CONSO:"amyloid-beta aggregates")) - pmid:19293145 + pubmed:27209302 - act(a(CHEBI:nicotine)) increases p(HGNC:CHRNA7) + bp(GO:"microglial cell activation") increases deg(p(CONSO:"amyloid-beta aggregates")) - pmid:17009926 + pubmed:27209302 - a(CHEBI:nicotine) increases act(p(HGNC:CHRNA7)) + bp(GO:"microglial cell activation") decreases path(MESH:"Plaque, Amyloid") - pmid:26472524 + pubmed:28877763 - a(CHEBI:nicotine) increases act(p(HGNC:CHRNA7)) + bp(GO:"microglial cell activation") positiveCorrelation act(p(MGI:Syk)) - pmid:19126755 + pubmed:28877763 - a(CHEBI:nicotine) association a(HBP:"beta-2-containing nAChR") + bp(GO:"microglial cell activation") positiveCorrelation p(MGI:Syk, pmod(go:0006468 ! "protein phosphorylation")) - pmid:19293145 + pubmed:27314526 - a(CHEBI:nicotine) increases bp(MESH:Neuroprotection) + bp(GO:"microglial cell activation") increases tloc(p(HGNC:IL18), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:19293145 + pubmed:30988501 - act(a(CHEBI:nicotine)) increases bp(MESH:Neuroprotection) + bp(GO:"microglial cell activation") increases a(MESH:"Inflammation Mediators") - pmid:19293145 + pubmed:30988501 - act(a(CHEBI:nicotine)) increases bp(MESH:Neuroprotection) + bp(GO:"microglial cell activation") increases bp(GO:"cytokine production") - pmid:19293145 + pubmed:30988501 - act(a(CHEBI:nicotine)) increases bp(MESH:Neuroprotection) + bp(GO:"microglial cell activation") increases act(p(INTERPRO:"Flavodoxin/nitric oxide synthase")) - pmid:19293145 + pubmed:30988501 - a(CHEBI:nicotine) increases bp(MESH:Neuroprotection) + bp(GO:"microglial cell activation") increases act(complex(GO:"NADPH oxidase complex")) - pmid:19721446 + pubmed:30988501 - a(CHEBI:nicotine) association bp(MESH:Neuroprotection) + bp(GO:"microglial cell activation") increases deg(a(MESH:Neurons)) - pmid:19293145 + pubmed:30988501 - a(CHEBI:nicotine) increases a(CHEBI:acetylcholine) + bp(GO:"microglial cell activation") negativeCorrelation path(MESH:"Hereditary Diffuse Leukoencephalopathy with Spheroids") - pmid:19293145 + pubmed:30988501 - a(CHEBI:nicotine) increases complex(a(MESH:Bungarotoxins), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + bp(GO:"microglial cell activation") increases a(MESH:"Neural Pathways") - pmid:19293145 + pubmed:30988501 - a(CHEBI:nicotine) decreases act(a(CHEBI:thapsigargin)) + bp(GO:"microglial cell activation") increases bp(GO:"neuroinflammatory response") - pmid:19293145 + pubmed:29179999 - act(a(CHEBI:nicotine)) decreases act(a(CHEBI:methamphetamine)) + a(PUBCHEM:444795) decreases path(MESH:Inflammation) - pmid:19293145 + pubmed:29179999 - a(CHEBI:nicotine) association bp(GO:"negative regulation of apoptotic process") + a(PUBCHEM:444795) decreases p(HGNC:IL6) - pmid:19293145 + pubmed:29179999 - act(a(CHEBI:nicotine)) increases p(FPLX:AKT, pmod(Ph)) + a(PUBCHEM:444795) decreases p(HGNC:IL12B) - pmid:19293145 + pubmed:29179999 - act(a(CHEBI:nicotine)) increases p(HGNC:BCL2) + a(PUBCHEM:444795) decreases p(HGNC:TNF) - pmid:19293145 + pubmed:29179999 - act(a(CHEBI:nicotine)) increases p(HGNC:BCL2L1) + a(PUBCHEM:444795) decreases act(p(FPLX:NFkappaB)) - pmid:19293145 + pubmed:29179999 - a(CHEBI:nicotine) increases p(HGNC:BAX, pmod(Ph)) + a(PUBCHEM:444795) decreases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) - pmid:19293145 + pubmed:29179999 - a(CHEBI:nicotine) decreases bp(GO:"apoptotic process") + a(PUBCHEM:444795) decreases p(HGNC:BACE1) - pmid:19293145 + pubmed:29179999 - a(CHEBI:nicotine) decreases bp(GO:"apoptotic process") + a(PUBCHEM:444795) decreases complex(g(HGNC:BACE1), p(FPLX:NFkappaB)) - pmid:25514383 + pubmed:29179999 - a(CHEBI:nicotine) decreases bp(GO:"apoptotic process") + a(PUBCHEM:3086007) decreases a(CHEBI:amyloid-beta) - pmid:19293145 + pubmed:29179999 - a(CHEBI:nicotine) decreases tloc(p(HGNC:BAX), fromLoc(GO:cytosol), toLoc(GO:mitochondrion)) + a(PUBCHEM:441921) decreases a(CHEBI:amyloid-beta) - pmid:19293145 + pubmed:29179999 - a(CHEBI:nicotine) increases act(p(HGNC:BAD)) + a(PUBCHEM:9918693) decreases a(CHEBI:amyloid-beta) - pmid:19293145 + pubmed:29179999 - a(CHEBI:nicotine) increases complex(p(FPLX:"PI3K_p85"), p(HGNC:CHRNA7), p(HGNC:FYN)) + a(PUBCHEM:441923) decreases a(CHEBI:amyloid-beta) - pmid:19293145 + pubmed:29179999 - act(a(CHEBI:nicotine)) increases p(HGNC:STAT3, pmod(Ph)) + a(PUBCHEM:441923) decreases r(HGNC:TLR3) - pmid:23178521 + pubmed:29179999 - a(CHEBI:nicotine) association p(HGNC:STAT3, pmod(Ph)) + a(PUBCHEM:441923) decreases p(HGNC:TLR3) - pmid:19293145 + pubmed:29179999 - act(a(CHEBI:nicotine)) increases p(RGD:Mapk3, pmod(Ph)) + a(PUBCHEM:441923) decreases r(HGNC:TLR4) - pmid:19293145 + pubmed:29179999 - act(a(CHEBI:nicotine)) increases p(RGD:Mapk14, pmod(Ph)) + a(PUBCHEM:441923) decreases p(HGNC:TLR4) - pmid:19293145 + pubmed:29179999 - act(a(CHEBI:nicotine)) increases p(RGD:Stat3, pmod(Ph)) + a(PUBCHEM:441923) decreases r(FPLX:NFkappaB) - pmid:19293145 + pubmed:29179999 - a(CHEBI:nicotine) increases act(g(HGNC:NIN)) + a(PUBCHEM:441923) decreases p(FPLX:NFkappaB) - pmid:19293145 + pubmed:29179999 - a(CHEBI:nicotine) increases act(g(HGNC:PTGS2)) + a(PUBCHEM:441923) decreases r(HGNC:TRAF6) - pmid:19293145 + pubmed:29179999 - a(CHEBI:nicotine) increases a(CHEBI:"prostaglandin E1(1-)") + a(PUBCHEM:441923) decreases p(HGNC:TRAF6) - pmid:19293145 + pubmed:29179999 - a(CHEBI:nicotine) increases bp(GO:"ERK1 and ERK2 cascade") + a(PUBCHEM:441923) decreases r(HGNC:TNF) - pmid:19293145 + pubmed:29179999 - a(CHEBI:nicotine) increases bp(GO:"MAPK cascade") + a(PUBCHEM:441923) decreases r(HGNC:IFNB1) - pmid:19293145 + pubmed:29179999 - act(a(CHEBI:nicotine)) increases composite(p(FPLX:JAK), p(HGNC:STAT3)) + a(PUBCHEM:24721561) decreases bp(GO:"neuron death") - pmid:19293145 + pubmed:29179999 - a(CHEBI:nicotine) decreases act(a(CHEBI:"N-methyl-D-aspartic acid")) + a(PUBCHEM:24721561) increases bp(GO:learning) - pmid:19293145 + pubmed:29179999 - a(CHEBI:nicotine) decreases a(MESH:Lipopolysaccharides) + a(PUBCHEM:24721561) increases bp(GO:memory) - pmid:19293145 + pubmed:29179999 - a(CHEBI:nicotine) association bp(GO:"calcium-mediated signaling") + a(PUBCHEM:24721561) decreases act(p(FPLX:NFkappaB)) - pmid:19293145 + pubmed:26979166 - a(CHEBI:nicotine) association p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors") + act(p(HGNC:TLR3)) increases r(MESH:Cytokines) + + - pmid:19293145 + pubmed:26551702 - a(CHEBI:nicotine) association p(HGNCGENEFAMILY:"Ryanodine receptors") + act(p(HGNC:TRAF6)) increases act(p(HGNC:NGF)) - pmid:19293145 + pubmed:30962309 - a(CHEBI:nicotine) association p(FPLX:ERK) + p(HGNC:TRAF6) increases p(HGNCGENEFAMILY:"IKK complex") - pmid:19293145 + pubmed:30962309 - act(a(CHEBI:nicotine)) association a(MESH:Calcineurin) + p(HGNC:TRAF6) increases r(HGNC:NLRP3) - pmid:19293145 + pubmed:30962309 - a(CHEBI:nicotine) increases a(CHEBI:"calcium(2+)") + p(HGNC:TRAF6) increases r(HGNC:PYCARD) - pmid:19293145 + pubmed:30962309 - a(CHEBI:nicotine) increases sec(a(HBP:"sAPP-beta")) + p(HGNC:TRAF6) increases r(HGNC:CASP1) - pmid:19293145 + pubmed:30962309 - a(CHEBI:nicotine) decreases a(HBP:"sAPP-gamma") + p(HGNC:TRAF6) increases p(HGNC:NLRP3) - pmid:17009926 + pubmed:30962309 - a(CHEBI:nicotine) increases act(p(FPLX:CHRN)) + p(HGNC:TRAF6) increases p(HGNC:PYCARD) - pmid:17009926 + pubmed:30962309 - a(CHEBI:nicotine) increases act(p(FPLX:CHRN)) + p(HGNC:TRAF6) increases p(HGNC:CASP1) - pmid:17009926 + pubmed:29661268 - a(CHEBI:nicotine) increases act(p(FPLX:CHRN)) + p(HGNC:TRAF6) increases p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) - pmid:28445721 + pubmed:22110360 - a(CHEBI:nicotine) regulates p(FPLX:CHRN) + p(HGNC:TRAF6) increases act(p(HGNC:MAP3K5)) - pmid:21482353 + pubmed:26631930 - a(CHEBI:nicotine) increases act(p(FPLX:CHRN)) + p(HGNC:TRAF6) increases p(HGNC:MAPT, pmod(go:0070534 ! "protein K63-linked ubiquitination")) - pmid:21482353 + pubmed:29179999 - a(CHEBI:nicotine) increases p(FPLX:CHRN) + a(PUBCHEM:164676) decreases act(p(HGNC:NOS2)) - pmid:21482353 + pubmed:29179999 - a(CHEBI:nicotine) increases p(FPLX:CHRN) + a(PUBCHEM:164676) decreases act(p(HGNC:MMP2)) - pmid:21482353 + pubmed:29179999 - a(CHEBI:nicotine) causesNoChange p(FPLX:CHRN) + a(PUBCHEM:164676) decreases act(p(HGNC:RELA)) - pmid:21787755 + pubmed:29179999 - a(CHEBI:nicotine) increases act(p(FPLX:CHRN)) + a(PUBCHEM:164676) decreases path(MESH:"Alzheimer Disease") - pmid:17009926 + pubmed:29179999 - a(CHEBI:nicotine) increases bp(GO:memory) + a(PUBCHEM:164676) decreases bp(GO:"apoptotic process") - pmid:25514383 + pubmed:29179999 - a(CHEBI:nicotine) increases bp(GO:memory) + a(PUBCHEM:164676) decreases path(MESH:Inflammation) - pmid:11230871 + pubmed:29179999 - a(CHEBI:nicotine) increases bp(GO:memory) + a(PUBCHEM:164676) decreases bp(GO:"neuron death") - pmid:11230871 + pubmed:29179999 - a(CHEBI:nicotine) increases bp(GO:memory) + a(PUBCHEM:164676) decreases p(HGNC:GFAP) - pmid:17009926 + pubmed:29179999 - a(CHEBI:nicotine) increases bp(GO:"circadian sleep/wake cycle, wakefulness") + a(PUBCHEM:164676) decreases p(FPLX:NFkappaB) - pmid:26813123 + pubmed:29179999 - a(CHEBI:nicotine) increases act(a(MESH:"Receptors, Nicotinic")) + a(PUBCHEM:164676) increases r(HGNC:RBFOX3) - pmid:21958873 + pubmed:29179999 - a(CHEBI:nicotine) increases act(a(MESH:"Receptors, Nicotinic")) + a(PUBCHEM:164676) increases a(MESH:"Nissl Bodies") - pmid:28391535 + pubmed:29179999 - a(CHEBI:nicotine) increases act(a(MESH:"Receptors, Nicotinic")) + a(PUBCHEM:164676) increases r(FPLX:IKB) - pmid:25514383 + pubmed:27594586 - a(CHEBI:nicotine) decreases a(CHEBI:"amyloid-beta polypeptide 42") + act(p(HGNC:MMP2)) increases bp(GO:"neuron death") - pmid:25514383 + pubmed:27594586 - a(CHEBI:nicotine) decreases a(CHEBI:"amyloid-beta polypeptide 42") + p(HGNC:MMP2) increases bp(GO:"neuron death") - pmid:25514383 + pubmed:26195256 - a(CHEBI:nicotine) decreases a(CHEBI:"amyloid-beta polypeptide 40") + p(HGNC:MMP2) increases deg(a(CHEBI:amyloid-beta, loc(GO:"extracellular region"))) - pmid:25514383 + pubmed:29626319 - a(CHEBI:nicotine) decreases a(CHEBI:"amyloid-beta polypeptide 40") + act(p(HGNC:MMP2)) increases deg(a(CHEBI:amyloid-beta)) - pmid:25514383 + pubmed:26195256 - a(CHEBI:nicotine) decreases a(CHEBI:"amyloid-beta") + p(HGNC:MMP2) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:21958873 + pubmed:26195256 - a(CHEBI:nicotine) causesNoChange a(CHEBI:"amyloid-beta") + act(p(HGNC:MMP2)) negativeCorrelation path(MESH:"Plaque, Amyloid") - pmid:25514383 + pubmed:25652642 - a(CHEBI:nicotine) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") + p(HGNC:GFAP) positiveCorrelation m(HGNC:MIR125B1) - pmid:25514383 + pubmed:29179999 - a(CHEBI:nicotine) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + a(CHEBI:"(+)-artemisinin") decreases path(MESH:Inflammation) - pmid:25514383 + pubmed:29179999 - a(CHEBI:nicotine) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") + a(CHEBI:"(+)-artemisinin") decreases act(p(FPLX:NFkappaB)) - pmid:21482353 + pubmed:29179999 - a(CHEBI:nicotine) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + a(CHEBI:"(+)-artemisinin") decreases a(CHEBI:amyloid-beta) - pmid:21482353 + pubmed:29179999 - a(CHEBI:nicotine) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + a(CHEBI:"(+)-artemisinin") decreases bp(GO:"NLRP3 inflammasome complex assembly") - pmid:25514383 + pubmed:28019679 - a(CHEBI:nicotine) increases path(MESH:"Memory, Episodic") + a(CHEBI:"(+)-artemisinin") decreases p(MGI:Nfkbia) - pmid:25514383 + pubmed:28019679 - a(CHEBI:nicotine) increases path(MESH:"Spatial Memory") + a(CHEBI:"(+)-artemisinin") decreases complex(GO:"NLRP3 inflammasome complex") - pmid:25514383 + pubmed:29179999 - a(CHEBI:nicotine) decreases a(HBP:"amyloid-beta oligomers") + a(PUBCHEM:440312) decreases a(CHEBI:"nitric oxide") - pmid:25514383 + pubmed:29179999 - a(CHEBI:nicotine) increases a(HBP:"Tau aggregates") + a(PUBCHEM:440312) decreases p(HGNC:TNF) - pmid:25514383 + pubmed:29179999 - a(CHEBI:nicotine) increases a(HBP:"Tau aggregates") + a(PUBCHEM:440312) decreases a(CHEBI:"prostaglandin E2") - pmid:25514383 + pubmed:29179999 - a(CHEBI:nicotine) increases bp(GO:"p38MAPK cascade") + a(PUBCHEM:440312) decreases p(HGNC:NOS2) - pmid:25514383 + pubmed:29179999 - a(CHEBI:nicotine) decreases path(MESH:"Plaque, Amyloid") + a(PUBCHEM:440312) decreases p(HGNC:PTGS2) - pmid:19721446 + pubmed:29179999 - a(CHEBI:nicotine) decreases path(MESH:"Plaque, Amyloid") + a(PUBCHEM:440312) decreases act(p(HGNC:LOX)) - pmid:25514383 + pubmed:29179999 - a(CHEBI:nicotine) increases bp(GO:"long-term synaptic potentiation") + a(PUBCHEM:440312) decreases a(CHEBI:"reactive oxygen species") - pmid:21482353 + pubmed:29179999 - a(CHEBI:nicotine) increases bp(GO:"long-term synaptic potentiation") + a(PUBCHEM:440312) decreases act(p(FPLX:ERK)) - pmid:28445721 + pubmed:29179999 - a(CHEBI:nicotine) increases surf(p(HBP:HBP00174)) + a(PUBCHEM:440312) decreases act(p(HGNC:MAPK14)) - pmid:21482353 + pubmed:29179999 - a(CHEBI:nicotine) increases complex(p(HGNC:CHRNA4), p(HGNC:CHRNA4), p(HGNC:CHRNB2), p(HGNC:CHRNB2), p(HGNC:CHRNB2)) + a(PUBCHEM:440312) decreases act(p(FPLX:NFkappaB)) - pmid:21482353 + pubmed:29179999 - a(CHEBI:nicotine) increases act(p(MGI:Lynx1)) + a(CHEBI:Geniposide) decreases act(p(FPLX:ERK)) - pmid:21482353 + pubmed:29179999 - a(CHEBI:nicotine) increases bp(GO:cognition) + a(CHEBI:Geniposide) decreases act(p(FPLX:IKB)) - pmid:19721446 + pubmed:29179999 - a(CHEBI:nicotine) increases bp(GO:cognition) + a(CHEBI:Geniposide) decreases act(p(FPLX:NFkappaB)) - pmid:21482353 + pubmed:29179999 - a(CHEBI:nicotine) increases act(a(HBP:"alpha-4 beta-2 nAChR")) + a(CHEBI:Geniposide) decreases r(HGNC:TNF) - pmid:21482353 + pubmed:29179999 - a(CHEBI:nicotine) increases act(a(HBP:"alpha-4 beta-2 nAChR")) + a(CHEBI:Geniposide) decreases r(HGNC:IL1B) - pmid:21482353 + pubmed:29179999 - a(CHEBI:nicotine) increases act(a(HBP:"alpha-4 beta-2 nAChR")) + a(CHEBI:Geniposide) decreases a(CHEBI:amyloid-beta) + + - pmid:21482353 + pubmed:27288790 - a(CHEBI:nicotine) increases act(a(HBP:"alpha-4 beta-2 nAChR")) + deg(p(FPLX:IKB)) increases act(complex(p(FPLX:NFkappaB), p(FPLX:NFkappaB))) + + + + + + - pmid:21482353 + pubmed:27288790 - a(CHEBI:nicotine) increases act(a(HBP:"alpha-4 beta-2 nAChR")) + r(HGNC:IL1B) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) - pmid:18174175 + pubmed:29179999 - a(CHEBI:nicotine) increases a(HBP:"alpha-4 beta-2 nAChR") + a(PUBCHEM:102336202) increases path(MESH:"Spatial Memory") - pmid:21482353 + pubmed:29179999 - a(CHEBI:nicotine) causesNoChange a(HBP:"alpha-4-containing nAChR") + a(PUBCHEM:102336202) decreases path(MESH:"Oxidative Stress") - pmid:21482353 + pubmed:29179999 - a(CHEBI:nicotine) increases act(a(HBP:"alpha-4-containing nAChR")) + a(PUBCHEM:102336202) decreases p(HGNC:NOS2) - pmid:21482353 + pubmed:29179999 - a(CHEBI:nicotine) increases act(a(HBP:"alpha-4-containing nAChR")) + a(PUBCHEM:102336202) decreases a(CHEBI:nitrotyrosine) - pmid:21482353 + pubmed:29179999 - a(CHEBI:nicotine) increases tloc(a(HBP:"alpha-4-containing nAChR"), fromLoc(GO:"endoplasmic reticulum"), toLoc(GO:"extracellular region")) + a(PUBCHEM:102336202) increases r(HGNC:IL4) - pmid:21482353 + pubmed:29179999 - a(CHEBI:nicotine) decreases act(a(MESH:"Dopaminergic Neurons")) + a(PUBCHEM:102336202) decreases a(MESH:Cytokines) - pmid:21482353 + pubmed:29179999 - a(CHEBI:nicotine) increases act(a(MESH:"GABAergic Neurons")) + a(PUBCHEM:102336202) decreases a(CHEBI:"nitric oxide") - pmid:21482353 + pubmed:29179999 - a(CHEBI:nicotine) decreases path(HBP:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") + a(PUBCHEM:102336202) decreases p(HGNC:IL1B) - pmid:11230871 + pubmed:29179999 - a(CHEBI:nicotine) increases bp(GO:learning) + a(PUBCHEM:102336202) decreases p(HGNC:TNF) - pmid:11230871 + pubmed:29179999 - a(CHEBI:nicotine) increases path(MESH:Attention) + a(PUBCHEM:102336202) decreases act(p(FPLX:ERK)) - pmid:19721446 + pubmed:29179999 - a(CHEBI:nicotine) increases bp(MESH:"Sensory Gating") + a(PUBCHEM:102336202) decreases act(p(FPLX:NFkappaB)) - pmid:19721446 + pubmed:29179999 - act(a(CHEBI:nicotine)) decreases path(MESH:Nociception) + a(CHEBI:"N(5)-ethyl-L-glutamine") increases bp(GO:memory) - pmid:22040696 + pubmed:29179999 - a(CHEBI:nicotine) increases act(a(MESH:"SNARE Proteins")) + a(CHEBI:"N(5)-ethyl-L-glutamine") decreases a(CHEBI:"amyloid-beta polypeptide 42") - pmid:18174175 + pubmed:29179999 - a(CHEBI:nicotine) increases a(MESH:"alpha6beta2 nicotinic acetylcholine receptor") + a(CHEBI:"N(5)-ethyl-L-glutamine") decreases bp(GO:"neuron death") - pmid:21958873 + pubmed:29179999 - a(CHEBI:nicotine) causesNoChange sec(p(HBP:"sAPP-beta")) + a(CHEBI:"N(5)-ethyl-L-glutamine") decreases act(p(FPLX:ERK)) - pmid:21958873 + pubmed:29179999 - a(CHEBI:nicotine) causesNoChange sec(p(HBP:"sAPP-alpha")) + a(CHEBI:"N(5)-ethyl-L-glutamine") decreases act(p(HGNC:MAPK14)) - pmid:21958873 + pubmed:29179999 - a(CHEBI:nicotine) causesNoChange act(complex(GO:"NF-kappaB complex")) + a(CHEBI:"N(5)-ethyl-L-glutamine") decreases act(p(FPLX:NFkappaB)) - pmid:23178521 + pubmed:29179999 - a(CHEBI:nicotine) decreases act(p(FPLX:NFkappaB)) + a(CHEBI:"1,8-cineole") decreases a(CHEBI:"reactive oxygen species") - pmid:28391535 + pubmed:29179999 - a(CHEBI:nicotine) increases act(a(MESH:"Adrenal Glands")) + a(CHEBI:"1,8-cineole") decreases a(CHEBI:"nitric oxide") - pmid:28391535 + pubmed:29179999 - a(CHEBI:nicotine) increases sec(a(CHEBI:adrenaline)) + a(CHEBI:"1,8-cineole") decreases r(HGNC:TNF) - pmid:28391535 + pubmed:29179999 - a(CHEBI:nicotine) decreases sec(a(CHEBI:"insulin (human)")) + a(CHEBI:"1,8-cineole") decreases r(HGNC:IL1B) - pmid:28391535 + pubmed:29179999 - a(CHEBI:nicotine) increases complex(a(CHEBI:nicotine), a(MESH:"nicotinic receptor alpha4beta2")) + a(CHEBI:"1,8-cineole") decreases r(HGNC:IL6) - pmid:28391535 + pubmed:29179999 - a(CHEBI:nicotine) increases complex(a(CHEBI:nicotine), a(MESH:"nicotinic receptor alpha4beta2")) + a(CHEBI:"1,8-cineole") decreases r(HGNC:NOS2) - pmid:28391535 + pubmed:29179999 - a(CHEBI:nicotine) negativeCorrelation path(MESH:"Motor Activity") + a(CHEBI:"1,8-cineole") decreases r(HGNC:PTGS2) - pmid:28391535 + pubmed:29179999 - a(CHEBI:nicotine) increases complex(a(CHEBI:nicotine), a(MESH:"Receptors, Nicotinic")) + a(CHEBI:"1,8-cineole") decreases r(FPLX:NFkappaB) - pmid:28391535 + pubmed:27288790 - a(CHEBI:nicotine) causesNoChange act(a(CHEBI:Mecamylamine)) + r(HGNC:NOS2) increases path(MESH:Inflammation) - pmid:28391535 + pubmed:29179999 - act(a(CHEBI:nicotine)) negativeCorrelation a(CHEBI:Hexamethonium) + a(PUBCHEM:442534) increases bp(GO:memory) - pmid:19126755 + pubmed:29179999 - a(MESH:"Electric Fish") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + a(PUBCHEM:442534) decreases a(CONSO:"amyloid-beta aggregates") - pmid:19126755 + pubmed:29179999 - a(HBP:"alpha-Bungarotoxin") decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + a(PUBCHEM:442534) decreases path(MESH:"Alzheimer Disease") - pmid:19126755 + pubmed:29179999 - a(HBP:"alpha-Bungarotoxin") increases complex(a(HBP:"alpha-Bungarotoxin"), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + a(PUBCHEM:442534) decreases act(p(FPLX:GSK3)) - pmid:19126755 + pubmed:29179999 - a(HBP:"alpha-Bungarotoxin") decreases a(CHEBI:dopamine, loc(GO:"extracellular region")) + a(PUBCHEM:442534) decreases act(p(FPLX:NFkappaB)) - pmid:21482353 + pubmed:29179999 - a(HBP:"alpha-Bungarotoxin") decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + a(PUBCHEM:442534) decreases bp(GO:"NLRP3 inflammasome complex assembly") - pmid:19126755 + pubmed:29179999 - bp(GO:signaling) association a(CHEBI:acetylcholine) + a(PUBCHEM:442534) decreases p(HGNC:TNF) - pmid:19126755 + pubmed:29179999 - act(p(HGNC:CHAT)) directlyIncreases rxn(reactants(a(CHEBI:"acetyl-CoA"), a(CHEBI:choline)), products(a(CHEBI:acetylcholine))) + a(PUBCHEM:442534) decreases p(HGNC:IL1B) - pmid:26813123 + pubmed:8282104 - p(HGNC:CHAT) increases rxn(reactants(a(CHEBI:"acetyl-CoA"), a(CHEBI:choline)), products(a(CHEBI:acetylcholine))) + p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:16273023 + pubmed:8282104 - act(p(HGNC:CHAT), ma(cat)) increases rxn(reactants(a(CHEBI:"acetyl-CoA"), a(CHEBI:choline)), products(a(CHEBI:acetylcholine))) + p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) - pmid:19293145 + pubmed:8282104 - p(HGNC:CHAT) negativeCorrelation g(HGNC:APOE) + p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) + + + pubmed:8282104 + + p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 235)) + + - pmid:26813123 + pubmed:8282104 - act(p(HGNC:CHAT)) negativeCorrelation path(MESH:"Huntington Disease") + p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) - pmid:26813123 + pubmed:8282104 - act(p(HGNC:CHAT)) decreases path(MESH:Dementia) + p(FPLX:GSK3) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) - pmid:24590577 + pubmed:8282104 - p(HGNC:CHAT) decreases a(CHEBI:acetylcholine) + p(FPLX:GSK3) association a(GO:microtubule) - pmid:25514383 + pubmed:8282104 - act(p(HGNC:CHAT)) increases a(CHEBI:acetylcholine) + p(FPLX:GSK3) association a(CONSO:CONSO00006) - pmid:18986241 + pubmed:8282104 - act(p(HGNC:CHAT)) directlyIncreases a(CHEBI:acetylcholine) + p(FPLX:GSK3) increases rxn(reactants(p(HGNC:MAPT)), products(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")))) - pmid:19721446 + pubmed:8282104 - p(HGNC:CHAT) increases a(CHEBI:acetylcholine) + p(FPLX:GSK3) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:18986241 + pubmed:27288790 - act(p(HGNC:CHAT)) decreases bp(HBP:Neurodegeneration) + bp(GO:"negative regulation of neuron apoptotic process") association p(FPLX:NFkappaB) - + + + pubmed:12428809 + + bp(GO:"negative regulation of neuron apoptotic process") association tloc(p(HGNC:APP), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + pubmed:27288790 + + bp(GO:"neuron differentiation") association p(FPLX:NFkappaB) + + - pmid:9089387 + pubmed:22110360 - a(CHEBI:"acetyl-CoA") increases a(CHEBI:acetylcholine) + bp(GO:"neuron differentiation") association p(FPLX:CREB, pmod(go:0006468 ! "protein phosphorylation")) - pmid:28002468 + pubmed:24590577 - a(CHEBI:"acetyl-CoA") increases bp(HBP:"cystein-dependent auto-acetylation") + bp(GO:"neuron differentiation") association p(HGNC:CHRM1) - pmid:17009926 + pubmed:18986241 - a(CHEBI:choline) increases act(p(FPLX:CHRN)) + bp(GO:"neuron differentiation") association bp(GO:"MAPK cascade") - pmid:26813123 + pubmed:27807169 - a(CHEBI:choline) increases a(CHEBI:acetylcholine) + bp(GO:"neuron differentiation") positiveCorrelation act(p(RGD:Cdk5)) - pmid:26088141 + pubmed:28884684 - act(a(CHEBI:choline)) increases a(CHEBI:"calcium(2+)") + bp(GO:"neuron differentiation") positiveCorrelation act(p(HGNC:DYRK1A), ma(go:0016301 ! "kinase activity")) - pmid:26088141 + pubmed:27288790 - act(a(CHEBI:choline)) association act(a(MESH:"Calcium Channels")) + bp(GO:"regulation of synaptic plasticity") association p(FPLX:NFkappaB) - pmid:26088141 + pubmed:27288790 - a(CHEBI:choline) association bp(MESH:"Pleckstrin Homology Domains") + bp(GO:"regulation of synaptic plasticity") negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:26088141 + pubmed:30444369 - a(CHEBI:choline) increases bp(MESH:"Pleckstrin Homology Domains") + bp(GO:"regulation of synaptic plasticity") association p(HGNC:SH3GL2) - pmid:26088141 + pubmed:11880483 - a(CHEBI:choline) decreases complex(p(FPLX:"G_protein"), p(HGNC:CHRNA7)) + bp(GO:"regulation of synaptic plasticity") association p(FPLX:p38, pmod(go:0006468 ! "protein phosphorylation")) - pmid:26088141 + pubmed:11880483 - a(CHEBI:choline) decreases complex(p(HGNC:CHRNA7), p(HGNC:GNAQ)) + bp(GO:"regulation of synaptic plasticity") association p(HGNCGENEFAMILY:"Mitogen-activated protein kinases", pmod(go:0006468 ! "protein phosphorylation")) - pmid:26088141 + pubmed:27041503 - a(CHEBI:choline) decreases complex(p(HGNC:CHRNA7), p(HGNCGENEFAMILY:"G protein subunits beta")) + bp(GO:"regulation of synaptic plasticity") increases a(NIFT:"Hippocampal atrophy") - pmid:21482353 + pubmed:25800888 - a(CHEBI:choline) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + bp(GO:"regulation of synaptic plasticity") association p(HGNC:WWC1) - pmid:21482353 + pubmed:21543606 - a(CHEBI:choline) increases act(a(HBP:"alpha-7-containing nAChR")) + bp(GO:"regulation of synaptic plasticity") association bp(GO:"axonal defasciculation") - pmid:19721446 + pubmed:21543606 - a(CHEBI:choline) increases bp(MESH:Neuroprotection) + bp(GO:"regulation of synaptic plasticity") association bp(GO:myelination) - pmid:19721446 + pubmed:17009926 - a(CHEBI:choline) decreases act(a(MESH:"alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid")) + bp(GO:"regulation of synaptic plasticity") association p(FPLX:CHRN) - pmid:26813123 + pubmed:17009926 - p(HGNC:CHRNA1) increases a(MESH:"Receptors, Nicotinic") + bp(GO:"regulation of synaptic plasticity") association p(FPLX:CHRN) - pmid:19126755 + pubmed:24590577 - p(HGNC:CHRNA4) negativeCorrelation path(MESH:"Alzheimer Disease") + bp(GO:"regulation of synaptic plasticity") association p(HGNC:CHRM1) - pmid:11230871 + pubmed:30106381 - p(HGNC:CHRNA4) negativeCorrelation path(MESH:"Alzheimer Disease") + bp(GO:"regulation of synaptic plasticity") association p(HGNC:DLG4) - pmid:19126755 + pubmed:22908190 - p(HGNC:CHRNA4) association p(HGNC:PTGS2) + bp(GO:"regulation of synaptic plasticity") association bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:19293145 + pubmed:22908190 - p(HGNC:CHRNA4) positiveCorrelation a(CHEBI:"amyloid-beta") + bp(GO:"regulation of synaptic plasticity") association bp(GO:endocytosis) - pmid:17009926 + pubmed:22908190 - p(HGNC:CHRNA4) positiveCorrelation a(CHEBI:"amyloid-beta") + bp(GO:"regulation of synaptic plasticity") association bp(GO:autophagy) - pmid:19293145 + pubmed:26631930 - act(p(HGNC:CHRNA4)) decreases act(a(CHEBI:"L-glutamate(2-)")) + bp(GO:"regulation of synaptic plasticity") association p(HGNC:MAPT) - pmid:19293145 + pubmed:27288790 - act(p(HGNC:CHRNA4)) increases act(a(CHEBI:nicotine)) + p(FPLX:IKB, pmod(go:0006468 ! "protein phosphorylation")) increases deg(p(FPLX:IKB)) - pmid:19721446 + pubmed:27288790 - p(HGNC:CHRNA4) increases act(a(CHEBI:nicotine)) + p(FPLX:IKB, pmod(go:0006468 ! "protein phosphorylation")) increases act(p(FPLX:NFkappaB)) - pmid:19293145 + pubmed:27288790 - p(HGNC:CHRNA4) association bp(GO:"lipid metabolic process") + act(complex(p(FPLX:NFkappaB), p(FPLX:NFkappaB))) increases tloc(complex(p(FPLX:NFkappaB), p(FPLX:NFkappaB)), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) - pmid:23038257 + pubmed:27288790 - p(HGNC:CHRNA4) association p(MESH:"Cytoskeletal Proteins") + act(complex(p(FPLX:NFkappaB), p(FPLX:NFkappaB))) increases act(complex(p(FPLX:NFkappaB), p(FPLX:NFkappaB)), ma(GO:"DNA binding")) - pmid:23038257 + pubmed:27288790 - p(HGNC:CHRNA4) association bp(GO:"intracellular receptor signaling pathway") + p(FPLX:NFkappaB, pmod(go:0006468 ! "protein phosphorylation", Ser, 536)) increases act(p(HGNC:RELA)) - pmid:17009926 + pubmed:26010758 - p(HGNC:CHRNA4) positiveCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + p(FPLX:NFkappaB, pmod(go:0006468 ! "protein phosphorylation", Ser, 536)) association path(MESH:"Plaque, Amyloid") + + + pubmed:27288790 + + bp(MESH:"Membrane Fluidity") association a(CHEBI:"reactive oxygen species") + + - pmid:26813123 + pubmed:27288790 - p(HGNC:CHRNA4) increases a(MESH:"Receptors, Nicotinic") + bp(GO:"ion transport") association a(CHEBI:"reactive oxygen species") + + + pubmed:25031639 + + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) decreases act(p(HGNC:MAPT), ma(GO:"microtubule binding")) + + - pmid:11230871 + pubmed:30985105 - p(HGNC:CHRNA4) decreases complex(a(CHEBI:cytisine), p(FPLX:CHRN)) + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) decreases act(p(HGNC:MAPT)) + + + pubmed:26195256 + + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation), loc(MESH:"Cerebrospinal Fluid")) positiveCorrelation p(HGNC:MAPT, loc(MESH:"Neurofibrillary Tangles")) + + - pmid:26813123 + pubmed:26631930 - p(HGNC:CHRNB1) increases a(MESH:"Receptors, Nicotinic") + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) increases tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) - pmid:26813123 + pubmed:26631930 - p(HGNC:CHRND) increases a(MESH:"Receptors, Nicotinic") + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) increases tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) - pmid:19126755 + pubmed:25031639 - act(p(HGNC:CHRNG)) increases bp(GO:"long-term synaptic potentiation") + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) increases p(CONSO:"Tau aggregates", loc(GO:cytosol)) - pmid:26813123 + pubmed:29844403 - p(HGNC:CHRNG) increases a(MESH:"Receptors, Nicotinic") + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) increases p(CONSO:"Tau aggregates") - pmid:26813123 + pubmed:25031639 - p(HGNC:CHRNE) increases a(MESH:"Receptors, Nicotinic") + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) increases p(MESH:"Neurofibrillary Tangles") - pmid:26813123 + pubmed:29844403 - p(HGNC:CHRNA2) increases a(MESH:"Receptors, Nicotinic") + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) increases p(MESH:"Neurofibrillary Tangles") - pmid:19721446 + pubmed:25031639 - p(HGNC:CHRNA2) decreases act(a(CHEBI:nicotine)) + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) increases p(CONSO:"paired helical filaments") - pmid:26813123 + pubmed:25031639 - p(HGNC:CHRNA3) increases a(MESH:"Receptors, Nicotinic") + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) negativeCorrelation bp(GO:"axonal transport") + + + pubmed:29844403 + + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) negativeCorrelation bp(GO:"axonal transport") + + - pmid:11230871 + pubmed:22611162 - p(HGNC:CHRNA3) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) decreases bp(GO:"axonal transport") - pmid:11230871 + pubmed:26631930 - p(HGNC:CHRNA3) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) decreases bp(GO:"axonal transport") - pmid:19721446 + pubmed:25031639 - p(HGNC:CHRNA3) association path(MESH:Craving) + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) negativeCorrelation bp(GO:"synaptic signaling") - pmid:19721446 + pubmed:22611162 - p(HGNC:CHRNA3) association path(MESH:Recurrence) + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) decreases bp(GO:"synaptic signaling") - pmid:19126755 + pubmed:25031639 - p(HGNC:CHRNA5) decreases path(MESH:"Inflammatory Bowel Diseases") + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) negativeCorrelation act(complex(GO:microtubule), ma(GO:"microtubule motor activity")) - pmid:26813123 + pubmed:29844403 - p(HGNC:CHRNA5) increases a(MESH:"Receptors, Nicotinic") + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) increases p(CONSO:"Tau oligomers") + + + pubmed:29844403 + + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) increases path(DOID:neuropathy) + + - pmid:19721446 + pubmed:29844403 - p(HGNC:CHRNA5) decreases act(a(CHEBI:nicotine)) + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) negativeCorrelation bp(GO:"cellular respiration") - pmid:26813123 + pubmed:30061532 - p(HGNC:CHRNA6) increases a(MESH:"Receptors, Nicotinic") + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) association path(MESH:"Lewy Body Disease") - pmid:21787755 + pubmed:30061532 - p(HGNC:CHRNA6) association path(MESH:Reward) + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:21787755 + pubmed:29758300 - p(HGNC:CHRNA6) association bp(MESH:"Drug Interactions") + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) increases path(MESH:"Alzheimer Disease") - pmid:21787755 + pubmed:30145931 - p(HGNC:CHRNA6) association sec(a(CHEBI:dopamine)) + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:19126755 + pubmed:17403556 - p(HGNC:CHRNA7) association a(MESH:Neurons) + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:19126755 + pubmed:25374103 - p(HGNC:CHRNA7) association complex(p(HGNC:CHRNA5), p(HGNC:CHRNA7)) + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:19126755 + pubmed:26631930 - p(HGNC:CHRNA7) association complex(p(HGNC:CHRNA7), p(HGNC:CHRNB2)) + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:19126755 + pubmed:24401760 - p(HGNC:CHRNA7) association complex(p(HGNC:CHRNA7), p(HGNC:CHRNB3)) + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + pubmed:30061532 + + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) positiveCorrelation path(MESH:"Frontotemporal Dementia") + + - pmid:19126755 + pubmed:30061532 - act(p(HGNC:CHRNA7)) increases bp(GO:"action potential initiation") + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) positiveCorrelation path(MESH:Schizophrenia) - pmid:19126755 + pubmed:30061532 - act(p(HGNC:CHRNA7, loc(GO:"axon terminus"))) regulates bp(GO:"synaptic transmission, glycinergic") + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) positiveCorrelation p(HGNC:CDK5) - pmid:19126755 + pubmed:17009926 - act(p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)", loc(GO:intracellular)) + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) positiveCorrelation p(HGNC:CHRNA7) - pmid:19126755 + pubmed:17009926 - act(p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)", loc(GO:intracellular)) + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) positiveCorrelation p(HGNC:CHRNA4) - pmid:19293145 + pubmed:18986241 - act(p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)") + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) association a(MESH:"Neurofibrillary Tangles") - pmid:22040696 + pubmed:26195256 - p(HGNC:CHRNA7) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:Cytoplasm)) + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) association a(MESH:"Neurofibrillary Tangles") - pmid:19126755 + pubmed:11230871 - act(p(HGNC:CHRNA7)) increases bp(GO:"neuronal action potential") + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) negativeCorrelation p(FPLX:CHRN) + + + + - pmid:19126755 + pubmed:19277525 - act(p(HGNC:CHRNA7, loc(GO:"glutamatergic synapse"))) regulates bp(GO:"synaptic transmission, dopaminergic") + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) increases a(GO:"neurofibrillary tangle") - pmid:19126755 + pubmed:22908190 - act(p(HGNC:CHRNA7, loc(GO:"glutamatergic synapse"))) increases a(CHEBI:"glutamate(2-)", loc(MESH:"Dopaminergic Neurons")) + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) association a(GO:"neurofibrillary tangle") - pmid:19126755 + pubmed:22299660 - p(HGNC:CHRNA7, loc(MESH:"Mossy Fibers, Hippocampal")) regulates a(CHEBI:"glutamate(2-)", loc(MESH:"Pyramidal Cells")) + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) decreases bp(GO:"microtubule polymerization") - pmid:19293145 + pubmed:26631930 - act(p(HGNC:CHRNA7)) decreases act(a(CHEBI:"glutamate(2-)")) + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) decreases bp(GO:"microtubule polymerization") - pmid:17009926 + pubmed:22299660 - act(p(HGNC:CHRNA7)) increases sec(a(CHEBI:"glutamate(2-)")) + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) negativeCorrelation act(p(FPLX:PPP2)) - pmid:19126755 + pubmed:21722302 - p(HGNC:CHRNA7) positiveCorrelation bp(GO:cognition) + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) decreases bp(GO:"cytoskeleton organization") - pmid:19126755 + pubmed:29758300 - act(p(HGNC:CHRNA7)) association bp(GO:cognition) + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) - pmid:19721446 + pubmed:30985105 - p(HGNC:CHRNA7) positiveCorrelation bp(GO:cognition) + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) - pmid:19721446 + pubmed:26631930 - act(p(HGNC:CHRNA7)) increases bp(GO:cognition) + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) - pmid:19126755 + pubmed:29758300 - p(HGNC:CHRNA7) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) increases a(CONSO:"Tau aggregates") - pmid:19293145 + pubmed:21882945 - p(HGNC:CHRNA7) association path(MESH:"Alzheimer Disease") + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) increases a(CONSO:"Tau aggregates") - pmid:11230871 + pubmed:26458742 - p(HGNC:CHRNA7) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) increases a(CONSO:"Tau aggregates") - pmid:22040696 + pubmed:26631930 - p(HGNC:CHRNA7) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) increases a(CONSO:"Tau aggregates") - pmid:29191965 + pubmed:29758300 - p(HGNC:CHRNA7) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) increases bp(GO:"microtubule depolymerization") + + + + + + - pmid:19126755 + pubmed:30145931 - act(p(HGNC:CHRNA7)) increases sec(a(CHEBI:"gamma-aminobutyric acid")) + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) positiveCorrelation path(MESH:Tauopathies) - pmid:19126755 + pubmed:22611162 - act(p(HGNC:CHRNA7)) regulates a(CHEBI:dopamine, loc(GO:"extracellular region")) + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) decreases bp(GO:"maintenance of synapse structure") - pmid:19126755 + pubmed:21734277 - act(p(HGNC:CHRNA7)) increases a(CHEBI:dopamine, loc(GO:"extracellular region")) + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) association p(CONSO:"Tau epitope, AT8", pmod(go:0006468 ! "protein phosphorylation")) + + - pmid:19126755 + pubmed:30985105 - act(p(HGNC:CHRNA7)) association path(MESH:"Sensory Gating") + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) increases a(CONSO:"Tau oligomers") - pmid:19126755 + pubmed:26195256 - act(p(HGNC:CHRNA7)) increases a(CHEBI:"amyloid-beta", loc(GO:intracellular)) + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) association a(MESH:"Neuropil Threads") + + - pmid:19293145 + pubmed:26631930 - p(HGNC:CHRNA7) positiveCorrelation a(CHEBI:"amyloid-beta") + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) increases complex(p(HGNC:MAPK8IP1), p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) - pmid:19293145 + pubmed:26631930 - p(HGNC:CHRNA7) decreases act(a(CHEBI:"amyloid-beta")) + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) increases complex(p(HGNC:MAPK8IP1), p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) - pmid:19293145 + pubmed:26631930 - p(HGNC:CHRNA7) increases a(CHEBI:"amyloid-beta") + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) increases complex(GO:"filamentous actin") - pmid:19293145 + pubmed:26631930 - p(HGNC:CHRNA7) association a(CHEBI:"amyloid-beta") + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) increases path(CONSO:Neurodegeneration) - pmid:17009926 + pubmed:26631930 - p(HGNC:CHRNA7) positiveCorrelation a(CHEBI:"amyloid-beta") + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) decreases act(a(GO:synapse)) - pmid:29191965 + pubmed:14963027 - p(HGNC:CHRNA7) regulates act(a(CHEBI:"amyloid-beta")) + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) association p(HGNC:HSPB1) - pmid:19126755 + pubmed:14963027 - act(p(HGNC:CHRNA7)) increases a(CHEBI:anandamide) + act(p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) increases bp(GO:"neuron apoptotic process") - pmid:19126755 + pubmed:17954934 - p(HGNC:CHRNA7) regulates bp(GO:"cell cycle") + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) negativeCorrelation p(HGNC:BAG1) - pmid:19126755 + pubmed:23487739 - p(HGNC:CHRNA7) regulates bp(MESH:Apoptosis) + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) decreases a(GO:microtubule) - pmid:19126755 + pubmed:19732809 - p(HGNC:CHRNA7) regulates bp(MESH:"Cell Differentiation") + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) negativeCorrelation p(HGNC:MAPT, pmod(CONSO:O-GlcNAcylation)) - pmid:19126755 + pubmed:25378699 - act(p(HGNC:CHRNA7)) association a(CHEBI:nicotine) + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) positiveCorrelation p(HGNC:MAPT, pmod(go:0016925 ! "protein sumoylation", Lys, 340)) - pmid:19126755 + pubmed:19623258 - p(HGNC:CHRNA7) regulates a(CHEBI:nicotine) + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) association a(CHEBI:"quinolinic acid") - pmid:19293145 + pubmed:27288790 - p(HGNC:CHRNA7) regulates act(a(CHEBI:nicotine)) + a(CHEBI:"hydrogen peroxide") increases act(p(FPLX:NFkappaB)) - pmid:19293145 + pubmed:27288790 - p(HGNC:CHRNA7) increases a(CHEBI:nicotine) + a(CHEBI:"hydrogen peroxide") increases act(p(FPLX:ERK)) - pmid:19126755 + pubmed:27288790 - p(HGNC:CHRNA7) regulates path(MESH:"Substance Withdrawal Syndrome") + a(CHEBI:"hydrogen peroxide") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:19293145 + pubmed:21861815 - p(HGNC:CHRNA7) association path(MESH:"Plaque, Amyloid") + a(CHEBI:"hydrogen peroxide") decreases p(HGNC:HIF1A) - pmid:19293145 + pubmed:14556719 - p(HGNC:CHRNA7) increases act(a(CHEBI:galanthamine)) + a(CHEBI:"hydrogen peroxide") increases bp(GO:"response to unfolded protein") - pmid:19293145 + pubmed:23531502 - act(p(HGNC:CHRNA7)) decreases act(a(CHEBI:ethanol)) + act(a(CHEBI:"hydrogen peroxide")) increases a(CONSO:"Tau aggregates") - pmid:19293145 + pubmed:23722080 - act(p(HGNC:CHRNA7)) decreases bp(GO:"cell death") + a(CHEBI:"hydrogen peroxide") increases bp(MESH:"Oxidative Stress") + + - pmid:19293145 + pubmed:23722080 - act(p(HGNC:CHRNA7)) increases a(CHEBI:glucose) + a(CHEBI:"hydrogen peroxide") positiveCorrelation composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) + + - pmid:19293145 + pubmed:27288790 - act(p(HGNC:CHRNA7)) increases a(MESH:Oxygen) + p(HGNC:IL18) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:19293145 + pubmed:24561250 - act(p(HGNC:CHRNA7)) decreases act(a(CHEBI:"L-glutamate(2-)")) + p(HGNC:IL18) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:19293145 + pubmed:27314526 - act(p(HGNC:CHRNA7)) causesNoChange act(a(CHEBI:"N-methyl-4-phenylpyridinium")) + p(HGNC:IL18) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:19293145 + pubmed:27314526 - act(p(HGNC:CHRNA7)) decreases act(p(HGNC:FAS)) + p(HGNC:IL18) association path(MESH:"Alzheimer Disease") + + + pubmed:27288790 + + p(HGNC:IL18) increases act(p(FPLX:NFkappaB)) + + - pmid:19293145 + pubmed:30962309 - act(p(HGNC:CHRNA7)) increases act(p(HGNC:JAK2)) + p(HGNC:IL18) association path(DOID:cancer) - pmid:19293145 + pubmed:30962309 - p(HGNC:CHRNA7) increases bp(GO:"MAPK cascade") + p(HGNC:IL18) association path(DOID:"multiple sclerosis") - pmid:19293145 + pubmed:30962309 - p(HGNC:CHRNA7) increases bp(GO:"MAPK cascade") + p(HGNC:IL18) association path(DOID:"rheumatic disease") - pmid:19293145 + pubmed:30967783 - act(p(HGNC:CHRNA7)) increases bp(GO:"calcium ion transport") + p(HGNC:IL18) increases bp(GO:"inflammatory response") - pmid:19293145 + pubmed:24561250 - act(p(HGNC:CHRNA7)) association bp(GO:"calcium-mediated signaling") + p(HGNC:IL18) increases bp(GO:"inflammatory response") - pmid:19293145 + pubmed:30967783 - p(HGNC:CHRNA7) increases act(p(HGNCGENEFAMILY:"Ryanodine receptors")) + p(HGNC:IL18) increases path(EFO:"experimental autoimmune encephalomyelitis") - - - + + + pubmed:23092889 + + p(HGNC:IL18) increases bp(GO:pyroptosis) + - + + + pubmed:24561250 + + p(HGNC:IL18) positiveCorrelation complex(GO:"inflammasome complex") + - pmid:17009926 + pubmed:27314526 - p(HGNC:CHRNA7) increases bp(GO:"neurotransmitter secretion") + p(HGNC:IL18) positiveCorrelation path(MESH:Dementia) - pmid:22040696 + pubmed:27314526 - p(HGNC:CHRNA7) increases bp(GO:"neurotransmitter secretion") + p(HGNC:IL18) increases bp(GO:"microglial cell activation") - pmid:17009926 + pubmed:27314526 - p(HGNC:CHRNA7) increases act(complex(GO:"voltage-gated calcium channel complex")) + p(HGNC:IL18) increases bp(GO:"astrocyte activation") - pmid:17009926 + pubmed:27314526 - act(p(HGNC:CHRNA7)) increases bp(GO:"synaptic transmission, glutamatergic") + p(HGNC:IL18) increases a(CHEBI:amyloid-beta) - pmid:17009926 + pubmed:27314526 - p(HGNC:CHRNA7) association a(HBP:"amyloid-beta aggregates") + p(HGNC:IL18) increases p(HGNC:GSK3B) - pmid:17009926 + pubmed:27314526 - p(HGNC:CHRNA7) positiveCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + p(HGNC:IL18) increases p(HGNC:CDK5) - pmid:26813123 + pubmed:27288790 - p(HGNC:CHRNA7) increases a(MESH:"Receptors, Nicotinic") + p(HGNC:CXCL10) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:26088141 + pubmed:27288790 - p(HGNC:CHRNA7) increases bp(HBP:"nAChR assembly") + p(HGNC:TGFB1) positiveCorrelation path(MESH:"Alzheimer Disease") - - - pmid:26088141 + pubmed:26304819 - p(HGNC:CHRNA7) increases p(HGNC:CHRNA7) + p(HGNC:TGFB1) biomarkerFor path(MESH:"Alzheimer Disease") - pmid:26088141 + pubmed:30967783 - p(HGNC:CHRNA7) increases complex(p(HGNC:CHRNA7), p(HGNC:GNAQ)) + p(HGNC:TGFB1) decreases bp(GO:"inflammatory response") - pmid:26088141 + pubmed:21718217 - p(HGNC:CHRNA7) increases complex(p(FPLX:"G_beta"), p(FPLX:"G_gamma"), p(HGNC:CHRNA7)) + p(HGNC:TGFB1) decreases a(MESH:Macrophages) - pmid:18986241 + pubmed:27288790 - p(HGNC:CHRNA7) increases complex(p(HGNC:APP), p(HGNC:CHRNA7)) + bp(GO:"protein kinase B signaling") increases act(p(FPLX:NFkappaB)) - pmid:18986241 + pubmed:30061532 - p(HGNC:CHRNA7) increases complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) + bp(GO:"protein kinase B signaling") association path(MESH:Schizophrenia) - - - + + + pubmed:30061532 + + bp(GO:"protein kinase B signaling") association path(MESH:Schizophrenia) + - pmid:19721446 + pubmed:30061532 - p(HGNC:CHRNA7) association a(MESH:Hippocampus) + bp(GO:"protein kinase B signaling") association p(HGNC:NRG1) - pmid:19721446 + pubmed:18986241 - p(HGNC:CHRNA7) association bp(GO:memory) + bp(GO:"protein kinase B signaling") regulates bp(MESH:"Cell Survival") - pmid:19721446 + pubmed:18986241 - act(p(HGNC:CHRNA7)) decreases bp(GO:memory) + bp(GO:"protein kinase B signaling") association p(FPLX:RAS) - pmid:19721446 + pubmed:18986241 - p(HGNC:CHRNA7) association bp(GO:learning) + bp(GO:"protein kinase B signaling") association p(HGNC:IRS1) - pmid:19721446 + pubmed:18986241 - p(HGNC:CHRNA7) association bp(MESH:Neuroprotection) + bp(GO:"protein kinase B signaling") association p(HGNC:GAB1) - pmid:19721446 + pubmed:14556719 - act(p(HGNC:CHRNA7)) decreases bp(MESH:Neuroprotection) + bp(GO:"neuron apoptotic process") positiveCorrelation p(HGNC:CCNE1) - pmid:19721446 + pubmed:29311797 - p(HGNC:CHRNA7) association bp(MESH:"Sensory Gating") + bp(GO:"neuron apoptotic process") decreases bp(GO:cognition) - pmid:19721446 + pubmed:14963027 - p(HGNC:CHRNA7) association a(CHEBI:clozapine) + bp(GO:"neuron apoptotic process") negativeCorrelation p(HGNC:HSPB1) - pmid:22040696 + pubmed:27068745 - p(HGNC:CHRNA7) regulates bp(GO:"chemical synaptic transmission") + bp(GO:"neuron apoptotic process") positiveCorrelation p(HGNC:UNC5C) - pmid:22040696 + pubmed:27288790 - p(HGNC:CHRNA7) regulates bp(GO:"neuron-neuron synaptic transmission") + bp(GO:"MAPK cascade") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:22040696 + pubmed:27288790 - p(HGNC:CHRNA7) association path(MESH:"Neurodegenerative Diseases") + bp(GO:"MAPK cascade") increases p(FPLX:IKB, pmod(go:0006468 ! "protein phosphorylation")) - - - pmid:22040696 + pubmed:21214928 - p(HGNC:CHRNA7) association p(HGNC:BDNF) + bp(GO:"MAPK cascade") association a(CHEBI:amyloid-beta) - pmid:22040696 + pubmed:19293145 - tloc(p(HGNC:CHRNA7), fromLoc(GO:"cell surface"), toLoc(GO:endosome)) increases act(p(HGNC:CREB1), ma(tscript)) + bp(GO:"MAPK cascade") increases a(CHEBI:amyloid-beta) - - - + + + pubmed:19126755 + + bp(GO:"MAPK cascade") increases act(p(CONSO:"alpha-4 beta-2 nAChR")) + - pmid:22040696 + pubmed:19126755 - p(HGNC:CHRNA7) negativeCorrelation path(MESH:Schizophrenia) + bp(GO:"MAPK cascade") regulates r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:22040696 + pubmed:19293145 - p(HGNC:CHRNA7) decreases path(MESH:"Renal Insufficiency") + bp(GO:"MAPK cascade") increases act(p(HGNC:BAD)) - pmid:22040696 + pubmed:19293145 - p(HGNC:CHRNA7) decreases bp(GO:"cytokine production") + bp(GO:"MAPK cascade") increases act(p(HGNC:MYC)) - pmid:22040696 + pubmed:19293145 - p(HGNC:CHRNA7) decreases bp(GO:"apoptotic process") + bp(GO:"MAPK cascade") increases act(p(HGNC:MYC)) - pmid:28901280 + pubmed:19293145 - p(HGNC:CHRNA7) regulates bp(MESH:"Cell Survival") + bp(GO:"MAPK cascade") increases act(p(FPLX:NFkappaB)) - pmid:28901280 + pubmed:19293145 - p(HGNC:CHRNA7) regulates path(MESH:Inflammation) + bp(GO:"MAPK cascade") increases act(p(HGNC:NOS1)) - pmid:28901280 + pubmed:24590577 - p(HGNC:CHRNA7) association path(MESH:Neoplasms) + bp(GO:"MAPK cascade") increases p(HGNC:BACE1) - pmid:28901280 + pubmed:18986241 - p(HGNC:CHRNA7) increases bp(GO:"intracellular receptor signaling pathway") + bp(GO:"MAPK cascade") association bp(GO:"apoptotic process") - pmid:28901280 + pubmed:18986241 - p(HGNC:CHRNA7) increases bp(GO:"JAK-STAT cascade") + bp(GO:"MAPK cascade") association bp(GO:"neuron differentiation") - pmid:29191965 + pubmed:18986241 - p(HGNC:CHRNA7) regulates bp(GO:"musculoskeletal movement") + bp(GO:"MAPK cascade") increases act(p(FPLX:RAS)) - pmid:29191965 + pubmed:18986241 - p(HGNC:CHRNA7) regulates act(a(GO:synapse)) + bp(GO:"MAPK cascade") increases act(p(FPLX:RAF)) - pmid:29191965 + pubmed:18986241 - p(HGNC:CHRNA7) association path(MESH:Tauopathies) + bp(GO:"MAPK cascade") increases act(p(FPLX:MEK)) - pmid:26813123 + pubmed:18986241 - p(HGNC:CHRNA9) increases a(MESH:"Receptors, Nicotinic") + bp(GO:"MAPK cascade") increases act(p(FPLX:P90RSK)) - pmid:28901280 + pubmed:18986241 - p(HGNC:CHRNA9) increases path(MESH:Neoplasms) + bp(GO:"MAPK cascade") increases act(p(HGNC:MAPKAPK2)) - pmid:26813123 + pubmed:23393546 - p(HGNC:CHRNA10) increases a(MESH:"Receptors, Nicotinic") + bp(GO:"MAPK cascade") negativeCorrelation path(DOID:"Huntington's disease") - pmid:17009926 + pubmed:23393546 - act(p(HGNC:CHRNB2)) increases bp(GO:"depolarization of postsynaptic membrane") + bp(GO:"MAPK cascade") negativeCorrelation path(DOID:"Huntington's disease") - pmid:17009926 + pubmed:27288790 - p(HGNC:CHRNB2) increases bp(GO:"circadian sleep/wake cycle, wakefulness") + bp(GO:"ERK1 and ERK2 cascade") increases act(p(FPLX:NFkappaB)) - pmid:26813123 + pubmed:21214928 - p(HGNC:CHRNB2) increases a(MESH:"Receptors, Nicotinic") + bp(GO:"ERK1 and ERK2 cascade") association a(CHEBI:amyloid-beta) + + + pubmed:19126755 + + bp(GO:"ERK1 and ERK2 cascade") increases act(a(CHEBI:nicotine)) + + - pmid:19721446 + pubmed:19293145 - p(HGNC:CHRNB2) association p(HGNCGENEFAMILY:Tubulins) + bp(GO:"ERK1 and ERK2 cascade") decreases bp(GO:"apoptotic process") - pmid:19721446 + pubmed:24590577 - p(HGNC:CHRNB2) association p(HGNC:DNM1) + bp(GO:"ERK1 and ERK2 cascade") regulates act(p(HGNC:ADAM10)) - pmid:19721446 + pubmed:24590577 - p(HGNC:CHRNB2) association p(HGNCGENEFAMILY:"Clathrin subunits") + bp(GO:"ERK1 and ERK2 cascade") regulates bp(CONSO:"APP processing") - pmid:19721446 + pubmed:23393546 - p(HGNC:CHRNB2) increases act(a(CHEBI:nicotine)) + bp(GO:"ERK1 and ERK2 cascade") increases bp(MESH:"Cell Survival") - pmid:26813123 + pubmed:23393546 - p(HGNC:CHRNB3) increases a(MESH:"Receptors, Nicotinic") + bp(GO:"ERK1 and ERK2 cascade") positiveCorrelation p(HGNC:NF2) - pmid:19126755 + pubmed:27594586 - p(HGNC:CHRNB4) association path(MESH:"Drug Tolerance") + bp(GO:"ERK1 and ERK2 cascade") regulates p(HGNC:MMP9) - pmid:26813123 + pubmed:27288790 - p(HGNC:CHRNB4) increases a(MESH:"Receptors, Nicotinic") + a(CHEBI:SB-239063) decreases act(p(HGNC:MAPK14)) + + + pubmed:27288790 + + a(CHEBI:SB-239063) decreases p(HGNC:NFKBIA, pmod(go:0006468 ! "protein phosphorylation")) + + - pmid:19721446 + pubmed:27288790 - p(HGNC:CHRNB4) decreases act(a(CHEBI:nicotine)) + a(CHEBI:SB-239063) decreases tloc(p(HGNC:RELA), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) - pmid:19721446 + pubmed:27288790 - p(HGNC:CHRNB4) association path(MESH:Craving) + a(CHEBI:"anthra[1,9-cd]pyrazol-6(2H)-one") decreases p(FPLX:JNK) - pmid:19721446 + pubmed:27288790 - p(HGNC:CHRNB4) association path(MESH:Recurrence) + a(CHEBI:"anthra[1,9-cd]pyrazol-6(2H)-one") increases act(p(HGNC:MAPK14)) - pmid:19126755 + pubmed:27288790 - p(HBP:"alpha-4 beta-2 nAChR") negativeCorrelation path(MESH:Aging) + a(CHEBI:"anthra[1,9-cd]pyrazol-6(2H)-one") increases p(HGNC:NFKBIA, pmod(go:0006468 ! "protein phosphorylation")) - pmid:19126755 + pubmed:27288790 - p(HBP:"alpha-4 beta-2 nAChR") negativeCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:"advanced glycation end-product") increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:19126755 + pubmed:24183963 - p(HBP:"alpha-4 beta-2 nAChR") negativeCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:"advanced glycation end-product") increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:19126755 + pubmed:27288790 - act(p(HBP:"alpha-4 beta-2 nAChR")) decreases bp(GO:"synaptic transmission, GABAergic") + a(CHEBI:"advanced glycation end-product") decreases bp(GO:memory) - pmid:19126755 + pubmed:27288790 - act(p(HBP:"alpha-4 beta-2 nAChR")) decreases act(complex(GO:"voltage-gated calcium channel complex")) + a(CHEBI:"advanced glycation end-product") increases bp(GO:"cellular protein catabolic process") - pmid:19126755 + pubmed:27288790 - act(p(HBP:"alpha-4 beta-2 nAChR", loc(MESH:"GABAergic Neurons"))) increases act(a(MESH:"Dopaminergic Neurons")) + a(CHEBI:"advanced glycation end-product") decreases bp(GO:"long-term synaptic potentiation") - pmid:19126755 + pubmed:24183963 - p(HBP:"alpha-4 beta-2 nAChR") positiveCorrelation bp(GO:cognition) + a(CHEBI:"advanced glycation end-product") directlyIncreases act(p(HGNC:AGER)) - pmid:26472524 + pubmed:8063802 - act(p(HBP:"alpha-4 beta-2 nAChR")) increases bp(GO:"depolarization of postsynaptic membrane") + a(CHEBI:"advanced glycation end-product") increases act(p(HGNC:AGER)) - pmid:19126755 + pubmed:26095350 - p(HBP:"alpha-6 alpha-4 beta-2 beta-3 nAChR", loc(MESH:"Basal Ganglia")) association path(MESH:"Parkinson Disease") + a(CHEBI:"advanced glycation end-product") increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 214)) - pmid:19126755 + pubmed:26095350 - p(HBP:"alpha-7-containing nAChR") increases bp(GO:"calcium ion transport into cytosol") + a(CHEBI:"advanced glycation end-product") increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) - pmid:26472524 + pubmed:26095350 - p(HBP:"alpha-7-containing nAChR") increases act(p(HGNC:CHRNA7)) + a(CHEBI:"advanced glycation end-product") increases p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) + + - pmid:11230871 + pubmed:8063802 - p(HBP:"alpha-7-containing nAChR") negativeCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:"advanced glycation end-product") decreases complex(a(GO:microtubule), p(HGNC:MAPT)) - pmid:19126755 + pubmed:8063802 - a(MESH:Manduca) association bp(GO:"establishment of blood-brain barrier") + a(CHEBI:"advanced glycation end-product") increases a(CONSO:"Tau aggregates") - pmid:19126755 + pubmed:18930136 - p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits", var("?")) decreases bp(GO:"response to nicotine") + bp(GO:"cellular protein catabolic process") regulates bp(GO:"cellular homeostasis") - pmid:19126755 + pubmed:18930136 - bp(GO:"establishment of blood-brain barrier") association a(MESH:Manduca) + bp(GO:"cellular protein catabolic process") negativeCorrelation path(MESH:Neoplasms) - pmid:19126755 + pubmed:18930136 - a(MESH:Neurons) increases deg(a(CHEBI:nicotine)) + bp(GO:"cellular protein catabolic process") negativeCorrelation path(CONSO:Neurodegeneration) - pmid:19126755 + pubmed:25036637 - a(MESH:Neurons) association p(HGNC:CHRNA7) + bp(GO:"cellular protein catabolic process") association p(HGNC:DCP1A) - pmid:19126755 + pubmed:25036637 - a(MESH:Neurons) regulates a(CHEBI:"kynurenic acid") + bp(GO:"cellular protein catabolic process") association p(HGNC:EDC3) - pmid:21482353 + pubmed:25036637 - a(MESH:Neurons) negativeCorrelation act(p(FPLX:CHRN)) + bp(GO:"cellular protein catabolic process") association p(HGNC:DDX6) - pmid:21482353 + pubmed:27288790 - a(MESH:Neurons) increases tloc(a(CHEBI:"gamma-aminobutyric acid"), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) + a(CHEBI:pentosidine) isA a(CHEBI:"advanced glycation end-product") - pmid:28901280 + pubmed:27288790 - a(MESH:Neurons) association p(MESH:"Receptors, Nicotinic") + a(CHEBI:pentosidine) positiveCorrelation path(MESH:"Alzheimer Disease") + + - pmid:24027553 + pubmed:27288790 - act(a(MESH:Neurons)) negativeCorrelation p(HGNC:MAPT) + a(CONSO:GLAP) isA a(CHEBI:"advanced glycation end-product") - pmid:29238289 + pubmed:27288790 - act(a(MESH:Neurons)) increases sec(p(HGNC:MAPT)) + a(CONSO:GLAP) positiveCorrelation path(MESH:"Alzheimer Disease") + + - pmid:29238289 + pubmed:27288790 - act(a(MESH:Neurons)) increases sec(p(HGNC:MAPT)) + complex(a(CHEBI:pentosidine), p(HGNC:AGER)) increases p(HGNC:BACE1) - pmid:27671637 + pubmed:27288790 - act(a(MESH:Neurons)) negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) + complex(a(CHEBI:pentosidine), p(HGNC:AGER)) increases act(p(FPLX:NFkappaB)) - pmid:19126755 + pubmed:27288790 - a(TAXONOMY:8616) increases a(HBP:"alpha-Bungarotoxin") + complex(a(CONSO:GLAP), p(HGNC:AGER)) increases p(HGNC:BACE1) - + + + pubmed:27288790 + + complex(a(CONSO:GLAP), p(HGNC:AGER)) increases act(p(FPLX:NFkappaB)) + + + + pubmed:27288790 + + p(HGNC:GSK3B) increases r(HGNC:BACE1) + + - pmid:19126755 + pubmed:26551702 - complex(a(MESH:"alpha-cobratoxin"), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + p(HGNC:GSK3B) increases deg(p(HGNC:NFE2L2)) - + + + pubmed:29121589 + + act(p(HGNC:GSK3B)) negativeCorrelation p(HGNC:NFE2L2) + - pmid:19126755 + pubmed:24355211 - complex(a(HBP:"kappa-Bungarotoxin"), p(HBP:"alpha-3 beta-4 nAChR")) decreases act(p(HBP:"alpha-3 beta-4 nAChR")) + p(HGNC:GSK3B) decreases p(HGNC:NFE2L2) - pmid:21787755 + pubmed:26551702 - a(HBP:"kappa-Bungarotoxin") decreases act(a(HBP:"alpha-3 beta-2 nAChR")) + p(HGNC:GSK3B) increases p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation")) - pmid:21787755 + pubmed:29121589 - a(HBP:"kappa-Bungarotoxin") decreases act(a(HBP:"alpha-6-containing nAChR")) + p(HGNC:GSK3B) increases p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation")) - pmid:19126755 + pubmed:26551702 - act(p(HBP:"alpha-3 beta-4 nAChR")) increases a(CHEBI:"calcium(2+)", loc(GO:intracellular)) + p(HGNC:GSK3B) increases p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation")) + + + pubmed:22372633 + + p(HGNC:GSK3B) increases act(p(HGNC:HDAC6), ma(GO:"deacetylase activity")) + + - pmid:19126755 + pubmed:29844403 - complex(a(HBP:"kappa-Bungarotoxin"), p(HGNC:CHRNB4)) decreases act(p(HGNC:CHRNB4)) + act(p(HGNC:GSK3B)) association p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) + + - pmid:19126755 + pubmed:29844403 - a(MESH:Conotoxins) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + act(p(HGNC:GSK3B)) association p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Tyr, 216)) + + - pmid:19126755 + pubmed:25546293 - a(MESH:Conotoxins) decreases act(p(HGNCGENEFAMILY:"Potassium voltage-gated channels")) + act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 33)) - pmid:19126755 + pubmed:25546293 - a(MESH:Conotoxins) decreases act(p(MESH:"Voltage-Gated Sodium Channels")) + act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 33)) - pmid:19721446 + pubmed:25546293 - a(MESH:Conotoxins) association complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) + act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 37)) - pmid:19721446 + pubmed:25546293 - a(MESH:Conotoxins) decreases act(complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9))) + act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 37)) - pmid:19721446 + pubmed:25546293 - a(MESH:Conotoxins) decreases path(MESH:Pain) + act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Thr, 41)) + + - pmid:19126755 + pubmed:25546293 - p(HGNCGENEFAMILY:"Potassium voltage-gated channels") association a(CHEBI:anandamide) + act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 41)) - pmid:19126755 + pubmed:30935091 - a(TAXONOMY:1163) increases a(CHEBI:"Anatoxin a") + p(HGNC:GSK3B) increases p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006468 ! "protein phosphorylation")) - - - pmid:19126755 + pubmed:30935091 - complex(a(CHEBI:"Anatoxin a"), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + p(HGNC:GSK3B) increases p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006468 ! "protein phosphorylation", Ser, 33)) - pmid:19126755 + pubmed:30935091 - a(TAXONOMY:92736) increases a(CHEBI:epibatidine) + p(HGNC:GSK3B) increases p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006468 ! "protein phosphorylation", Ser, 37)) - pmid:19293145 + pubmed:30935091 - a(CHEBI:epibatidine) causesNoChange bp(GO:memory) + p(HGNC:GSK3B) increases p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006468 ! "protein phosphorylation", Thr, 41)) + + - pmid:19293145 + pubmed:29661268 - a(CHEBI:epibatidine) causesNoChange bp(GO:cognition) + act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:19293145 + pubmed:30444369 - a(CHEBI:epibatidine) causesNoChange path(MESH:"Plaque, Amyloid") + act(p(HGNC:GSK3B)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:19293145 + pubmed:21156028 - a(CHEBI:epibatidine) causesNoChange bp(MESH:"Neurofibrillary Tangles") + p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:28132910 + pubmed:22530628 - a(CHEBI:epibatidine) decreases complex(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"), a(PUBCHEM:16068384)) + act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - + + + pubmed:12428809 + + p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + - pmid:19126755 + pubmed:29758300 - complex(a(CHEBI:epibatidine), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + p(HGNC:GSK3B) regulates p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - + + + pubmed:21882945 + + act(p(HGNC:GSK3B)) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + - pmid:19126755 + pubmed:29191965 - complex(a(CHEBI:epibatidine), p(HBP:"alpha-4 beta-2 nAChR")) increases act(p(HBP:"alpha-4 beta-2 nAChR")) + p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - + + + pubmed:29311797 + + act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + - pmid:19126755 + pubmed:12551948 - complex(a(MESH:methyllycaconitine), p(HGNC:CHRNA7)) decreases act(p(HGNC:CHRNA7, loc(MESH:Muscles))) + act(p(HGNC:GSK3B)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:19293145 + pubmed:10998059 - a(MESH:methyllycaconitine) decreases act(p(HGNC:CHRNA7)) + act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:19293145 + pubmed:27314526 - a(MESH:methyllycaconitine) decreases act(p(HGNC:CHRNA7)) + p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:19293145 + pubmed:29661268 - a(MESH:methyllycaconitine) increases bp(MESH:Neuroprotection) + p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:19293145 + pubmed:30697142 - a(MESH:methyllycaconitine) decreases path(HBP:neurotoxicity) + act(p(HGNC:GSK3B)) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:25881725 + pubmed:12428809 - a(MESH:methyllycaconitine) decreases act(a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide")) + p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:25881725 + pubmed:18494933 - a(MESH:methyllycaconitine) decreases act(a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide")) + act(p(HGNC:GSK3B)) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:25881725 + pubmed:24183963 - a(MESH:methyllycaconitine) decreases act(a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide")) + act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:25881725 + pubmed:18494933 - a(MESH:methyllycaconitine) decreases act(a(CHEBI:galanthamine)) + act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) directlyIncreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:25881725 + pubmed:29661268 - a(MESH:methyllycaconitine) decreases act(a(CHEBI:galanthamine)) + p(HGNC:GSK3B) increases path(DOID:"neurodegenerative disease") + + - pmid:25881725 + pubmed:22122372 - a(MESH:methyllycaconitine) decreases act(a(CHEBI:galanthamine)) + p(HGNC:GSK3B) increases p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Thr, 654)) - pmid:25881725 + pubmed:22122372 - a(MESH:methyllycaconitine) decreases act(p(MGI:Chrna7)) + p(HGNC:GSK3B) increases p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Thr, 668)) - pmid:25881725 + pubmed:22122372 - a(MESH:methyllycaconitine) decreases act(p(MGI:Chrna7)) + p(HGNC:GSK3B) increases p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Ser, 665)) - pmid:25881725 + pubmed:30515821 - a(MESH:methyllycaconitine) decreases p(MGI:Chrna7) + p(HGNC:GSK3B) increases p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 40), pmod(go:0006468 ! "protein phosphorylation", Ser, 44)) - pmid:25881725 + pubmed:30515821 - a(MESH:methyllycaconitine) decreases path(MESH:"Spatial Memory") + p(HGNC:GSK3B) increases act(p(HGNC:DNM1L), ma(GO:"GTPase activity")) - pmid:25881725 + pubmed:30515821 - a(MESH:methyllycaconitine) causesNoChange r(MGI:Chrna7) + p(HGNC:GSK3B) regulates bp(GO:"mitochondrial fission") - pmid:19721446 + pubmed:30515821 - a(MESH:methyllycaconitine) decreases act(a(DRUGBANK:Facinicline)) + p(HGNC:GSK3B) increases act(p(HGNC:CASP3)) - + + + pubmed:30515821 + + p(HGNC:GSK3B) increases a(CHEBI:amyloid-beta) + - pmid:19126755 + pubmed:30697142 - complex(a(MESH:methyllycaconitine), p(HGNC:CHRNA6)) decreases act(p(HGNC:CHRNA6, loc(MESH:Muscles))) + act(p(HGNC:GSK3B)) increases a(CHEBI:amyloid-beta) - + + + pubmed:30515821 + + p(HGNC:GSK3B) increases path(EFO:"memory impairment") + - pmid:19126755 + pubmed:30515821 - complex(a(MESH:methyllycaconitine), p(HGNC:CHRNA3)) decreases act(p(HGNC:CHRNA3, loc(MESH:Muscles))) + p(HGNC:GSK3B) increases p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 616)) - pmid:19126755 + pubmed:22530628 - r(HGNC:CHRNA3) association p(HGNCGENEFAMILY:"ETS transcription factor family") + act(p(HGNC:GSK3B)) causesNoChange a(CONSO:"amyloid-beta aggregates") - pmid:19126755 + pubmed:22530628 - r(HGNC:CHRNB4) association p(HGNCGENEFAMILY:"ETS transcription factor family") + act(p(HGNC:GSK3B)) decreases bp(GO:"neuron death") - pmid:21787755 + pubmed:22530628 - r(HGNC:CHRNB4) association r(HGNC:CHRNA4) + act(p(HGNC:GSK3B)) increases bp(MESH:"Neuronal Plasticity") - pmid:21787755 + pubmed:22530628 - r(HGNC:CHRNA4) association r(HGNC:CHRNB4) + act(p(HGNC:GSK3B)) increases bp(MESH:"Long-Term Potentiation") - pmid:21787755 + pubmed:26979166 - r(HGNC:CHRNA6) association path(MESH:Reward) + act(p(HGNC:GSK3B)) decreases bp(MESH:"Long-Term Potentiation") + + + + - pmid:21787755 + pubmed:30697142 - r(HGNC:CHRNA6) association bp(MESH:"Drug Interactions") + p(HGNC:GSK3B) increases bp(GO:"programmed cell death") - pmid:21787755 + pubmed:30697142 - r(HGNC:CHRNA6) association sec(a(CHEBI:dopamine)) + act(p(HGNC:GSK3B)) negativeCorrelation bp(GO:"learning or memory") - pmid:19126755 + doi:"10.4172/2168-975X.1000126" - a(MESH:Fetus) increases r(HGNC:CHRNA3, loc(MESH:Brain)) + p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) - pmid:19126755 + pubmed:25331948 - path(MESH:"Trauma, Nervous System") increases r(HGNC:CHRNA3, loc(MESH:Brain)) + p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) - pmid:24561250 + pubmed:14612456 - path(MESH:"Trauma, Nervous System") increases path(MESH:"Alzheimer Disease") + p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) - pmid:24561250 + pubmed:17078951 - path(MESH:"Trauma, Nervous System") increases complex(GO:"inflammasome complex") + act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) - pmid:19126755 + pubmed:19459590 - a(MESH:Adult) decreases r(HGNC:CHRNA3, loc(MESH:Neurons)) + act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) - pmid:19126755 + pubmed:29844403 - a(MESH:Adult) increases r(HGNC:CHRNA4, loc(MESH:Neurons)) + act(p(HGNC:GSK3B)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) - + + + doi:"10.4172/2168-975X.1000126" + + p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + + + + pubmed:25331948 + + p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + + - pmid:19126755 + pubmed:14612456 - r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") increases bp(HBP:"nAChR assembly") + p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) - + + + pubmed:17078951 + + act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + - pmid:19126755 + pubmed:19459590 - act(complex(p(HGNC:JUN), p(HGNC:SP1)), ma(tscript)) increases r(HGNC:CHRNB4) + act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + + + doi:"10.4172/2168-975X.1000126" + + p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) + + - pmid:18494933 + pubmed:17078951 - p(HGNC:JUN) partOf p(FPLX:AP1) + act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) - pmid:19126755 + doi:"10.4172/2168-975X.1000126" - act(p(HGNC:SOX10)) increases r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) - + + + pubmed:25331948 + + p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) + - pmid:19126755 + pubmed:14612456 - composite(p(HGNC:CHRNA7), p(HGNC:NGF)) increases r(HGNC:CHRNB4) + p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) - pmid:19126755 + pubmed:17078951 - p(HGNCGENEFAMILY:"ETS transcription factor family") association r(HGNC:CHRNA3) + act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) - pmid:19126755 + pubmed:19459590 - p(HGNCGENEFAMILY:"ETS transcription factor family") association r(HGNC:CHRNB4) + act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) + + + pubmed:24653673 + + p(HGNC:GSK3B) association path(MESH:"Alzheimer Disease") + + - pmid:19126755 + pubmed:24653673 - complex(p(HGNC:CHRNA5), p(HGNC:CHRNA7)) association p(HGNC:CHRNA7) + act(p(HGNC:GSK3B)) negativeCorrelation a(GO:"microtubule cytoskeleton") + + + pubmed:24653673 + + act(p(HGNC:GSK3B)) negativeCorrelation a(GO:"neurofilament cytoskeleton") + + - pmid:19126755 + pubmed:24653673 - complex(p(HGNC:CHRNA7), p(HGNC:CHRNB2)) association p(HGNC:CHRNA7) + act(p(HGNC:GSK3B)) negativeCorrelation p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation")) + + + pubmed:24653673 + + act(p(HGNC:GSK3B)) negativeCorrelation bp(CONSO:"APP processing") + + - pmid:25514383 + pubmed:24653673 - complex(p(HGNC:CHRNA7), p(HGNC:CHRNB2)) increases a(HBP:"alpha-7 beta-2 nAChR") + act(p(HGNC:GSK3B)) negativeCorrelation bp(GO:neurogenesis) - pmid:25514383 + pubmed:24653673 - complex(p(HGNC:CHRNA7), p(HGNC:CHRNB2)) increases surf(a(HBP:"alpha-7 beta-2 nAChR")) + act(p(HGNC:GSK3B)) positiveCorrelation bp(GO:"negative regulation of synaptic plasticity") + + + pubmed:24653673 + + act(p(HGNC:GSK3B)) positiveCorrelation bp(GO:"apoptotic process") + + - pmid:19126755 + pubmed:24653673 - complex(p(HGNC:CHRNA7), p(HGNC:CHRNB3)) association p(HGNC:CHRNA7) + act(p(HGNC:GSK3B)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + + + pubmed:24653673 + + act(p(HGNC:GSK3B)) increases p(FPLX:PPP2, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) + + - pmid:19126755 + pubmed:24653673 - a(MESH:Muscles) association complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) + act(p(HGNC:GSK3B)) decreases p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation", Leu, 309)) - pmid:19126755 + pubmed:24653673 - a(MESH:Muscles) association complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE), loc(MESH:"Neuromuscular Junction")) + act(p(HGNC:GSK3B)) decreases p(HGNC:PPP2CB, pmod(go:0006479 ! "protein methylation", Leu, 309)) - pmid:19126755 + pubmed:24653673 - a(MESH:Muscles) increases r(HGNC:CHRNA1) + act(p(HGNC:GSK3B)) decreases act(p(HGNC:LCMT1)) - pmid:19126755 + pubmed:24653673 - a(MESH:Muscles) increases r(HGNC:CHRNB1) + act(p(HGNC:GSK3B)) increases act(p(HGNC:PPME1)) - pmid:19126755 + pubmed:24653673 - a(MESH:Muscles) increases r(HGNC:CHRND) + act(p(HGNC:GSK3B)) increases p(HGNC:SET) - pmid:19126755 + pubmed:12428809 - a(MESH:Muscles) increases r(HGNC:CHRNG) + p(HGNC:GSK3B) decreases complex(a(MESH:Microtubules), p(HGNC:MAPT)) - + + + pubmed:12428809 + + p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396), pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + - + + + pubmed:12428809 + + p(HGNC:GSK3B) increases a(MESH:Axons) + - pmid:19126755 + pubmed:12428809 - complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) association a(MESH:Muscles) + p(HGNC:GSK3B) association bp(GO:"axonal transport") - pmid:19126755 + pubmed:21734277 - complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG), loc(GO:"cell surface")) + act(p(HGNC:GSK3B)) decreases bp(GO:"axonal transport") - pmid:23038257 + pubmed:21861815 - complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) association a(CHEBI:chlorpromazine) + p(HGNC:GSK3B) increases p(HGNC:HIF1A, pmod(go:0006468 ! "protein phosphorylation")) - pmid:26813123 + pubmed:30606258 - complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) increases p(FPLX:CHRN) + act(p(HGNC:GSK3B)) negativeCorrelation p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) - + + + pubmed:30606258 + + p(HGNC:GSK3B) association bp(GO:"regulation of insulin receptor signaling pathway") + - + + + pubmed:30606258 + + p(HGNC:GSK3B) increases p(CONSO:"Tau isoform F (441 aa)", frag("187_441"), pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) + - pmid:19126755 + pubmed:30606258 - complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE), loc(MESH:"Neuromuscular Junction")) association a(MESH:Muscles) + p(HGNC:GSK3B) increases p(CONSO:"Tau isoform F (441 aa)", frag("187_441"), pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) - pmid:19126755 + pubmed:27299292 - complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE)) decreases deg(complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE))) + p(HGNC:GSK3B) decreases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) - pmid:19126755 + pubmed:27299292 - bp(GO:"depolarization of postsynaptic membrane") increases r(HGNC:CHRNE) + p(HGNC:GSK3B) increases composite(p(HGNC:TFEB), p(HGNC:YWHAQ)) - pmid:19126755 + pubmed:27299292 - bp(GO:"depolarization of postsynaptic membrane") increases act(complex(GO:"voltage-gated calcium channel complex")) + act(p(HGNC:GSK3B)) decreases act(a(MESH:Lysosomes)) - pmid:17009926 + pubmed:27299292 - bp(GO:"depolarization of postsynaptic membrane") increases bp(GO:"regulation of action potential firing rate") + p(HGNC:GSK3B) regulates act(a(MESH:Lysosomes)) - pmid:26472524 + pubmed:27299292 - bp(GO:"depolarization of postsynaptic membrane") increases bp(GO:"regulation of action potential firing rate") + p(HGNC:GSK3B) regulates bp(GO:autophagy) - pmid:17009926 + pubmed:21882945 - bp(GO:"depolarization of postsynaptic membrane") increases bp(GO:"long-term synaptic potentiation") + p(HGNC:GSK3B) increases act(p(HGNC:MARK2)) - pmid:19126755 + pubmed:22419736 - r(HGNC:CHRNE) decreases complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) + act(p(HGNC:GSK3B)) negativeCorrelation p(FPLX:AMPK) - pmid:19126755 + pubmed:30640040 - r(HGNC:CHRNE) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE)) + p(HGNC:GSK3B) association a(PUBCHEM:71295844) - - - - - - - pmid:19126755 + pubmed:29191965 - composite(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRNG), loc(GO:"endoplasmic reticulum")) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRNG)) + p(HGNC:GSK3B) association path(MESH:Tauopathies) - - - - - pmid:19126755 + pubmed:11812770 - complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRNG), loc(GO:"endoplasmic reticulum")) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) + p(HGNC:GSK3B) directlyIncreases complex(p(HGNC:GSK3B), p(HGNC:MAPT)) - - - - - - - - - pmid:19126755 + pubmed:11812770 - complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG), loc(GO:"endoplasmic reticulum")) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) + p(HGNC:GSK3B) positiveCorrelation complex(p(HGNC:GSK3B), p(HGNC:MAPT)) - - - pmid:19126755 + pubmed:11812770 - composite(complex(p(HGNC:CHRNA1), p(HGNC:CHRND)), complex(p(HGNC:CHRNA1), p(HGNC:CHRNG))) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) + p(HGNC:GSK3B) directlyIncreases complex(p(HGNC:GSK3B), p(HGNC:MAPT, frag("1_244"))) - + + + pubmed:11812770 + + p(HGNC:GSK3B) directlyDecreases complex(p(HGNC:GSK3B), p(HGNC:MAPT, frag("245_369"))) + @@ -64545,199 +65207,209 @@

Statements

- pmid:19126755 + pubmed:11812770 - a(MESH:Oocytes) association complex(p(HGNC:CHRNA4), p(HGNC:CHRNA7), p(HGNC:CHRNB2)) + p(HGNC:GSK3B) directlyDecreases complex(p(HGNC:GSK3B), p(HGNC:MAPT, frag("245_441"))) - - - + + + pubmed:14612456 + + p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) + - pmid:19126755 + pubmed:17078951 - complex(p(HGNC:CHRNA4), p(HGNC:CHRNA7), p(HGNC:CHRNB2)) association a(MESH:Oocytes) + act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) - pmid:19126755 + pubmed:19459590 - a(MESH:Hippocampus) increases p(HBP:"alpha-4 beta-2 nAChR") + act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) - pmid:19126755 + pubmed:18494933 - a(MESH:Hippocampus) increases p(HGNC:CHRNA7) + act(p(HGNC:GSK3B)) negativeCorrelation bp(GO:"Wnt signaling pathway") - pmid:19721446 + pubmed:18494933 - a(MESH:Hippocampus) association p(HGNC:CHRNA7) + act(p(HGNC:GSK3B)) increases p(GO:"neurofibrillary tangle") - pmid:24511233 + pubmed:18494933 - a(MESH:Hippocampus) association bp(GO:cognition) + act(p(HGNC:GSK3B)) negativeCorrelation bp(GO:"neuron development") + + - pmid:24511233 + pubmed:12551948 - a(MESH:Hippocampus) association bp(GO:learning) + p(HGNC:GSK3B) isA complex(p(HGNC:GSK3B), p(HGNC:MAPT), p(HGNC:YWHAZ)) - pmid:24511233 + pubmed:12551948 - a(MESH:Hippocampus) association bp(GO:learning) + p(HGNC:GSK3B) association p(HGNC:YWHAZ) - pmid:24511233 + pubmed:23531502 - a(MESH:Hippocampus) association bp(GO:memory) + act(p(HGNC:GSK3B)) association a(CONSO:"Tau aggregates") - pmid:24511233 + pubmed:7514173 - a(MESH:Hippocampus) association bp(GO:memory) + act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(FPLX:CREB, pmod(go:0006468 ! "protein phosphorylation")) - pmid:19721446 + pubmed:7514173 - a(MESH:Hippocampus) association bp(GO:memory) + act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MBP, pmod(go:0006468 ! "protein phosphorylation")) - pmid:24511233 + pubmed:7514173 - a(MESH:Hippocampus) association p(HGNC:CHRM4) + act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:CSN3, pmod(go:0006468 ! "protein phosphorylation")) - pmid:24590577 + pubmed:7514173 - a(MESH:Hippocampus) association p(HGNC:CHRM1) + act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:PPP1R2, pmod(go:0006468 ! "protein phosphorylation")) - pmid:24590577 + pubmed:7514173 - a(MESH:Hippocampus) association p(HGNC:CHRM2) + act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:CSNK2B, pmod(go:0006468 ! "protein phosphorylation")) - pmid:24590577 + pubmed:17078951 - a(MESH:Hippocampus) association p(HGNC:CHRM3) + act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 181)) - pmid:19126755 + pubmed:17078951 - a(MESH:Ganglia) increases p(HBP:"alpha-3 beta-4 nAChR") + act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) - pmid:19126755 + pubmed:19459590 - a(MESH:Ganglia) increases p(HBP:"alpha-4 beta-2 nAChR") + act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) - + + + pubmed:17078951 + + act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 217)) + - pmid:19126755 + pubmed:17078951 - composite(a(MESH:"HEK293 Cells"), g(HGNC:CHRNA7)) increases r(HGNC:CHRNA7) + act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) - pmid:19126755 + pubmed:17078951 - composite(a(MESH:"HEK293 Cells"), g(HGNC:CHRNA7)) decreases act(p(HGNC:CHRNA7)) + act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 212)) - pmid:19126755 + pubmed:9089387 - g(HGNC:CHRNA7) increases p(HGNC:CHRNA7) + act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(FPLX:PDH, pmod(go:0006468 ! "protein phosphorylation")) - pmid:19126755 + pubmed:9089387 - g(HGNC:CHRNA7) association path(MESH:"Sensory Gating") + p(HGNC:GSK3B) isA p(ECCODE:2.7.11.26) @@ -64746,102 +65418,117 @@

Statements

- pmid:18986241 + pubmed:26501932 - r(HGNC:CHRNA7) negativeCorrelation path(MESH:D003071) + p(HGNC:GSK3B) partOf a(CONSO:"GVD bodies") - pmid:18986241 + pubmed:25331948 - r(HGNC:CHRNA7) regulates act(a(MESH:D059329)) + act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) increases p(CONSO:"Tau epitope, PHF1") - pmid:18986241 + pubmed:28176663 - r(HGNC:CHRNA7) increases path(MESH:D009410) + act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) positiveCorrelation a(CONSO:"Braak_Stage I") - pmid:11230871 + pubmed:28176663 - r(HGNC:CHRNA7) positiveCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) positiveCorrelation a(CONSO:"Braak_Stage II") - pmid:19126755 + pubmed:28176663 - a(MESH:"Cell Line") regulates r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) negativeCorrelation a(CONSO:"Braak_Stage V") - pmid:19126755 + pubmed:24355211 - a(MESH:"Cell Line") regulates complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) + p(HGNC:GSK3B) positiveCorrelation bp(MESH:"Oxidative Stress") - + + + pubmed:24355211 + + p(HGNC:GSK3B) negativeCorrelation bp(GO:learning) + - pmid:19126755 + pubmed:24355211 - composite(g(HGNC:CHRNA4), g(HGNC:CHRNB2)) increases complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) + p(HGNC:GSK3B) negativeCorrelation bp(GO:memory) - + + + pubmed:24355211 + + act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) + - + + + pubmed:24355211 + + act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 235)) + - pmid:25514383 + pubmed:27288790 - complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) increases a(HBP:"alpha-4 beta-2 nAChR") + p(HGNC:GSK3A) causesNoChange r(HGNC:BACE1) - pmid:19721446 + pubmed:30606258 - complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) association a(MESH:"Dopaminergic Neurons") + p(HGNC:GSK3A) increases p(CONSO:"Tau isoform F (441 aa)", frag("187_441"), pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) - pmid:19126755 + pubmed:30606258 - p(HGNC:CHRNA7, frag("23_46")) increases complex(p(HGNC:CHRNA7), p(HGNC:CHRNA7)) + p(HGNC:GSK3A) increases p(CONSO:"Tau isoform F (441 aa)", frag("187_441"), pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) @@ -64850,1844 +65537,1874 @@

Statements

- pmid:19126755 + pubmed:30640040 - p(MESH:"Cysteine Loop Ligand-Gated Ion Channel Receptors") isA p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + p(HGNC:GSK3A) association a(PUBCHEM:71295844) - pmid:19126755 + pubmed:22817713 - a(MESH:"Endoplasmic Reticulum") regulates bp(HBP:"nAChR assembly") + p(HGNC:GSK3A) decreases bp(GO:"anterograde axonal protein transport") - pmid:19126755 + pubmed:30837838 - a(MESH:"Endoplasmic Reticulum") regulates p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + p(HGNC:GSK3A) association p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation")) - pmid:19126755 + pubmed:27288790 - a(MESH:"Endoplasmic Reticulum") increases deg(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits", loc(GO:"endoplasmic reticulum"))) + composite(p(HGNC:GSK3B), p(HGNC:RELA)) increases r(HGNC:BACE1) + + - pmid:19126755 + pubmed:21722302 - bp(HBP:"nAChR assembly") increases p(HBP:"alpha-3 beta-4 nAChR", loc(GO:"cell surface")) + p(HGNC:UCHL1) association bp(GO:"chaperone-mediated autophagy") - pmid:19126755 + pubmed:30740335 - bp(HBP:"nAChR assembly") increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG), loc(GO:"cell surface")) + p(HGNC:UCHL1) association path(MESH:"Endoplasmic Reticulum Stress") + + - pmid:19126755 + pubmed:14556719 - a(CHEBI:"proteasome inhibitor") decreases deg(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits", loc(GO:"endoplasmic reticulum"))) + p(HGNC:UCHL1) decreases bp(GO:"protein ubiquitination") + + - pmid:19126755 + pubmed:14556719 - a(CHEBI:"proteasome inhibitor") increases bp(HBP:"nAChR assembly") + p(HGNC:UCHL1) increases p(HGNC:SNCA, pmod(go:0016567 ! "protein ubiquitination")) - pmid:29626319 + pubmed:14556719 - a(CHEBI:"proteasome inhibitor") increases bp(GO:autophagy) + p(HGNC:UCHL1) decreases path(MESH:"Deglutition Disorders") - pmid:29626319 + pubmed:14556719 - a(CHEBI:"proteasome inhibitor") decreases p(HGNC:MAPT) + p(HGNC:UCHL1) positiveCorrelation a(MESH:"Solitary Nucleus") - pmid:29626319 + pubmed:14556719 - a(CHEBI:"proteasome inhibitor") increases p(HGNC:BAG3) + p(HGNC:UCHL1) positiveCorrelation a(MESH:"Area Postrema") - - - - - pmid:21787755 + pubmed:22908190 - a(HBP:"alpha-3 beta-2 nAChR") regulates sec(a(CHEBI:"gamma-aminobutyric acid")) + p(HGNC:UCHL1) association path(MESH:"Parkinson Disease") - - - - - - - - - pmid:19126755 + pubmed:22908190 - composite(a(CHEBI:nicotine), g(HGNC:CHRNA4)) increases p(HGNC:CHRNA4) + p(HGNC:UCHL1) association path(MESH:"Alzheimer Disease") - - - pmid:19126755 + pubmed:22908190 - composite(a(CHEBI:nicotine), g(HGNC:CHRNA6)) increases p(HGNC:CHRNA6) + p(HGNC:UCHL1) increases act(a(GO:synapse)) - + + + pubmed:22908190 + + p(HGNC:UCHL1) increases bp(GO:memory) + - pmid:19126755 + pubmed:22908190 - composite(a(CHEBI:nicotine), g(HGNC:CHRNB2)) increases p(HGNC:CHRNB2) + p(HGNC:UCHL1) decreases bp(GO:"protein polyubiquitination") - + + + pubmed:27288790 + + a(MESH:Lipopolysaccharides) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) + - pmid:19126755 + pubmed:27288790 - composite(a(CHEBI:nicotine), g(HGNC:CHRNB3)) increases p(HGNC:CHRNB3) + a(MESH:Lipopolysaccharides) increases p(HGNC:TNF) - pmid:19126755 + pubmed:27288790 - act(a(HBP:"alpha-4 beta-2 nAChR")) decreases act(a(MESH:Interneurons)) + a(MESH:Lipopolysaccharides) increases tloc(p(HGNC:TNF), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:19293145 + pubmed:27288790 - a(HBP:"alpha-4 beta-2 nAChR") association path(MESH:"Alzheimer Disease") + a(MESH:Lipopolysaccharides) increases p(HGNC:IL1B) - pmid:25514383 + pubmed:27288790 - a(HBP:"alpha-4 beta-2 nAChR") negativeCorrelation bp(GO:"calcium ion transport") + a(MESH:Lipopolysaccharides) increases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:25514383 + pubmed:30967783 - act(a(HBP:"alpha-4 beta-2 nAChR")) decreases bp(GO:"cellular calcium ion homeostasis") + a(MESH:Lipopolysaccharides) increases a(NCIT:C156004) - pmid:25514383 + pubmed:26445701 - act(a(HBP:"alpha-4 beta-2 nAChR")) increases path(HBP:"mitochondrial dysfunction") + a(MESH:Chemokines) increases bp(MESH:"Transendothelial and Transepithelial Migration") - pmid:25514383 + pubmed:30967783 - act(a(HBP:"alpha-4 beta-2 nAChR")) increases bp(GO:"response to oxidative stress") + a(MESH:Chemokines) increases a(MESH:"Leukocytes, Mononuclear", loc(NCIT:C74601)) - pmid:21482353 + pubmed:30967783 - a(HBP:"alpha-4 beta-2 nAChR") positiveCorrelation bp(GO:cognition) + a(MESH:Chemokines, loc(NCIT:C74601)) increases a(MESH:Macrophages, loc(MESH:Brain)) - pmid:21482353 + pubmed:26979166 - a(HBP:"alpha-4 beta-2 nAChR") positiveCorrelation a(MESH:"Dopaminergic Neurons") + a(MESH:Chemokines) increases deg(a(MESH:"White Matter")) - pmid:21482353 + pubmed:26979166 - a(HBP:"alpha-4 beta-2 nAChR") positiveCorrelation a(MESH:"GABAergic Neurons") + a(MESH:Chemokines) increases deg(a(MESH:"Gray Matter")) - pmid:19126755 + pubmed:30988501 - sec(a(CHEBI:"gamma-aminobutyric acid")) increases bp(GO:"hyperpolarization of postsynaptic membrane") + a(MESH:Chemokines) increases bp(GO:"central nervous system development") - pmid:21482353 + pubmed:27288790 - a(CHEBI:"gamma-aminobutyric acid") increases act(p(HGNC:GABBR1)) + m(MIRBASE:hsa-mir-125b-1) decreases r(HGNC:ALOX15) - pmid:21482353 + pubmed:27288790 - a(CHEBI:"gamma-aminobutyric acid") increases act(p(HGNC:GABBR2)) + m(MIRBASE:hsa-mir-125b-1) decreases r(HGNC:VDR) - pmid:21482353 + pubmed:25001178 - a(CHEBI:"gamma-aminobutyric acid") decreases tloc(a(CHEBI:"glutamate(2-)"), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) + m(MIRBASE:hsa-mir-125b-1) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:19126755 + pubmed:25001178 - bp(GO:"action potential initiation") decreases a(MESH:"Electric Stimulation", loc(GO:"Schaffer axon collateral")) + m(MIRBASE:hsa-mir-125b-1) increases act(p(HGNC:CDK5R1)) - pmid:19126755 + pubmed:25001178 - bp(GO:"action potential initiation") increases act(a(MESH:"Perforant Pathway")) + m(MIRBASE:hsa-mir-125b-1) increases act(p(HGNC:CDK5), ma(go:0016301 ! "kinase activity")) - pmid:26813123 + pubmed:25001178 - bp(GO:"action potential initiation") increases tloc(a(CHEBI:choline), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + m(MIRBASE:hsa-mir-125b-1) increases act(p(HGNC:MAPK3), ma(go:0016301 ! "kinase activity")) - pmid:26813123 + pubmed:25001178 - bp(GO:"action potential initiation") increases tloc(a(CHEBI:choline), fromLoc(GO:"synaptic cleft"), toLoc(MESH:"Cholinergic Neurons")) + m(MIRBASE:hsa-mir-125b-1) increases act(p(HGNC:MAPK1), ma(go:0016301 ! "kinase activity")) - pmid:26813123 + pubmed:25001178 - bp(GO:"action potential initiation") increases a(CHEBI:acetylcholine) + m(MIRBASE:hsa-mir-125b-1) decreases p(HGNC:PPP1CA) - pmid:26813123 + pubmed:25001178 - bp(GO:"action potential initiation") increases a(CHEBI:acetylcholine) + m(MIRBASE:hsa-mir-125b-1) decreases p(HGNC:DUSP6) - pmid:26813123 + pubmed:25001178 - bp(GO:"action potential initiation") association complex(a(GO:"plasma membrane"), p(HGNC:SLC5A7)) + m(MIRBASE:hsa-mir-125b-1) decreases p(HGNC:DUSP6) - pmid:28901280 + pubmed:25001178 - bp(GO:"action potential initiation") association p(MESH:"Receptors, Nicotinic") + m(MIRBASE:hsa-mir-125b-1) decreases p(HGNC:BCL2L2) - pmid:19126755 + pubmed:27288790 - act(p(FPLX:CREB), ma(tscript)) regulates bp(GO:"gene expression") + m(MIRBASE:hsa-mir-125b-2) decreases r(HGNC:ALOX15) - pmid:19126755 + pubmed:27288790 - act(p(FPLX:CREB)) association bp(MESH:"Neuronal Plasticity") + m(MIRBASE:hsa-mir-125b-2) decreases r(HGNC:VDR) - pmid:19126755 + pubmed:27288790 - act(p(FPLX:CREB)) association path(MESH:"Tobacco Use Disorder") + m(MIRBASE:hsa-mir-146a) positiveCorrelation path(MESH:"Alzheimer Disease") - - - pmid:27550730 + pubmed:27288790 - act(p(FPLX:CREB)) negativeCorrelation act(p(HGNC:PDE5A)) + m(MIRBASE:hsa-mir-146a) association r(HGNC:IRAK1) - pmid:27550730 + pubmed:30962309 - act(p(FPLX:CREB)) negativeCorrelation act(p(FPLX:HDAC)) + m(MIRBASE:hsa-mir-146a) decreases r(HGNC:IRAK1) - pmid:27550730 + pubmed:27288790 - act(p(FPLX:CREB)) increases p(FPLX:Histone, pmod(Ac)) + m(MIRBASE:hsa-mir-146a) association bp(GO:"immune response") - pmid:19126755 + pubmed:27288790 - act(complex(GO:"voltage-gated calcium channel complex")) increases bp(GO:"calcineurin-mediated signaling") + m(MIRBASE:hsa-mir-146a) increases path(HP:Neurodegeneration) - pmid:19126755 + pubmed:30962309 - act(complex(GO:"voltage-gated calcium channel complex")) decreases act(p(FPLX:CREB), ma(tscript)) + m(MIRBASE:hsa-mir-146a) association a(MESH:"Neural Pathways") - pmid:19126755 + pubmed:30962309 - complex(GO:"voltage-gated calcium channel complex") association a(CHEBI:anandamide) + m(MIRBASE:hsa-mir-146a) association a(MESH:"Immune System") - pmid:19126755 + pubmed:30962309 - p(HBP:"alpha-4-containing nAChR") increases sec(a(CHEBI:dopamine)) + m(MIRBASE:hsa-mir-146a) negativeCorrelation p(OMIT:0016854) - pmid:11230871 + pubmed:30962309 - p(HBP:"alpha-4-containing nAChR") negativeCorrelation path(MESH:"Alzheimer Disease") + m(MIRBASE:hsa-mir-146a) decreases p(HGNCGENEFAMILY:"Toll like receptors") - pmid:19126755 + pubmed:30962309 - p(HBP:"alpha-6-containing nAChR") increases sec(a(CHEBI:dopamine)) + m(MIRBASE:hsa-mir-146a) decreases p(HGNC:IL1R1) - pmid:19126755 + pubmed:30962309 - bp(GO:"neuronal action potential") increases sec(a(CHEBI:dopamine)) + m(MIRBASE:hsa-mir-146a) decreases p(HGNC:TRAF6) - pmid:28445721 + pubmed:30962309 - bp(GO:"neuronal action potential") regulates p(FPLX:CHRN) + m(MIRBASE:hsa-mir-146a) decreases p(HGNC:IRAK1) - pmid:19126755 + pubmed:30962309 - a(CHEBI:"glutamate(2-)", loc(MESH:"Dopaminergic Neurons")) increases bp(GO:"synaptic transmission, dopaminergic") + m(MIRBASE:hsa-mir-146a) decreases r(HGNC:TRAF6) - pmid:19293145 + pubmed:30962309 - act(a(CHEBI:"glutamate(2-)")) increases bp(HBP:Excitotoxicity) + m(MIRBASE:hsa-mir-146a) decreases p(HGNC:NLRP3) - pmid:17009926 + pubmed:30962309 - sec(a(CHEBI:"glutamate(2-)")) increases bp(GO:"long-term synaptic potentiation") + m(MIRBASE:hsa-mir-146a) decreases r(HGNC:NLRP3) - pmid:16273023 + pubmed:30962309 - a(CHEBI:"glutamate(2-)") directlyIncreases bp(GO:"GO:0014047") + m(MIRBASE:hsa-mir-146a) decreases p(HGNC:PYCARD) - pmid:16273023 + pubmed:30962309 - a(CHEBI:"glutamate(2-)") directlyIncreases act(p(MESH:D017470)) + m(MIRBASE:hsa-mir-146a) decreases r(HGNC:PYCARD) - pmid:19126755 + pubmed:30962309 - a(MESH:Neuroglia) increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + m(MIRBASE:hsa-mir-146a) decreases p(HGNC:CASP1) - pmid:19126755 + pubmed:30962309 - a(MESH:Keratinocytes) increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + m(MIRBASE:hsa-mir-146a) decreases r(HGNC:CASP1) - pmid:28901280 + pubmed:30962309 - a(MESH:Keratinocytes) increases complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) + m(MIRBASE:hsa-mir-146a) directlyDecreases path(OMIT:0016001) - pmid:28901280 + pubmed:30962309 - a(MESH:Keratinocytes) increases p(HGNC:CHRNA9) + m(MIRBASE:hsa-mir-146a) regulates complex(MESH:Inflammasomes) - pmid:19126755 + pubmed:30962309 - a(MESH:"Endothelial Cells") increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + m(MIRBASE:hsa-mir-146a) negativeCorrelation path(DOID:"rheumatoid arthritis") - pmid:28901280 + pubmed:30962309 - a(MESH:"Endothelial Cells") increases a(MESH:Acetylcholine) + m(MIRBASE:hsa-mir-146a) negativeCorrelation path(DOID:"multiple sclerosis") - pmid:28901280 + pubmed:30962309 - a(MESH:"Endothelial Cells") increases a(MESH:"Choline O-Acetyltransferase") + m(MIRBASE:hsa-mir-146a) negativeCorrelation path(DOID:"systemic lupus erythematosus") - pmid:24027553 + pubmed:30962309 - a(MESH:"Endothelial Cells") increases sec(a(CHEBI:Thrombin)) + m(MIRBASE:hsa-mir-146a, loc(MESH:"T-Lymphocytes, Regulatory")) association path(DOID:arthritis) - pmid:24027553 + pubmed:30962309 - a(MESH:"Endothelial Cells") increases a(CHEBI:Thrombin) + m(MIRBASE:hsa-mir-146a) association bp(GO:"glomerular filtration") - pmid:19126755 + pubmed:27288790 - a(MESH:"Cholinesterase Inhibitors") causesNoChange act(p(HGNC:CHRNA7)) + m(MIRBASE:hsa-mir-155) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:19293145 + pubmed:27288790 - act(a(MESH:"Cholinesterase Inhibitors")) decreases act(a(CHEBI:"amyloid-beta")) + m(MIRBASE:hsa-mir-155) positiveCorrelation path(MESH:"Multiple Sclerosis") - pmid:19293145 + pubmed:30962309 - act(a(MESH:"Cholinesterase Inhibitors")) decreases act(a(CHEBI:"L-glutamate(2-)")) + m(MIRBASE:hsa-mir-155) negativeCorrelation p(OMIT:0016854) - pmid:26813123 + pubmed:30962309 - a(MESH:"Cholinesterase Inhibitors") increases a(CHEBI:acetylcholine) + m(MIRBASE:hsa-mir-155) decreases p(HGNCGENEFAMILY:"Toll like receptors") - pmid:26813123 + pubmed:30962309 - a(MESH:"Cholinesterase Inhibitors") increases bp(GO:cognition) + m(MIRBASE:hsa-mir-155) decreases p(HGNC:IL1R1) - pmid:19126755 + pubmed:30962309 - a(CHEBI:physostigmine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + m(MIRBASE:hsa-mir-155) decreases p(HGNC:MYD88) - pmid:19126755 + pubmed:30962309 - a(CHEBI:physostigmine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits", loc(MESH:"Neuromuscular Junction"))) + m(MIRBASE:hsa-mir-155) decreases r(HGNC:NFKB1) - pmid:19126755 + pubmed:30962309 - a(CHEBI:physostigmine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + m(MIRBASE:hsa-mir-155) regulates complex(MESH:Inflammasomes) - pmid:18986241 + pubmed:30962309 - a(CHEBI:physostigmine) decreases path(MESH:D000544) + m(MIRBASE:hsa-mir-155) negativeCorrelation path(DOID:"rheumatoid arthritis") - pmid:19126755 + pubmed:30962309 - a(CHEBI:"nicotinic antagonist") causesNoChange act(a(CHEBI:galanthamine)) + m(MIRBASE:hsa-mir-155) negativeCorrelation path(DOID:"multiple sclerosis") - pmid:19126755 + pubmed:30962309 - a(CHEBI:"nicotinic antagonist") causesNoChange act(a(CHEBI:physostigmine)) + m(MIRBASE:hsa-mir-155) negativeCorrelation path(DOID:"systemic lupus erythematosus") - pmid:19126755 + pubmed:30962309 - a(CHEBI:"nicotinic antagonist") causesNoChange a(CHEBI:codeine) + m(MIRBASE:hsa-mir-155) association path(DOID:proteinuria) - pmid:17009926 + pubmed:27288790 - a(CHEBI:"nicotinic antagonist") decreases sec(a(CHEBI:acetylcholine)) + r(HGNC:IRAK1) association m(MIRBASE:hsa-mir-146a) - pmid:17009926 + pubmed:27288790 - a(CHEBI:"nicotinic antagonist") decreases sec(a(CHEBI:dopamine)) + path(MESH:"Multiple Sclerosis") positiveCorrelation m(MIRBASE:hsa-mir-155) - pmid:17009926 + pubmed:27794524 - a(CHEBI:"nicotinic antagonist") decreases sec(a(CHEBI:noradrenaline)) + path(MESH:"Multiple Sclerosis") isA path(MESH:"Central Nervous System Diseases") - pmid:17009926 + pubmed:27956442 - a(CHEBI:"nicotinic antagonist") decreases sec(a(CHEBI:serotonin)) + path(MESH:"Multiple Sclerosis") isA path(MESH:"Central Nervous System Diseases") - pmid:17009926 + pubmed:27794524 - a(CHEBI:"nicotinic antagonist") decreases sec(a(CHEBI:"glutamate(2-)")) + path(MESH:"Multiple Sclerosis") increases path(MESH:"Demyelinating Diseases") - pmid:17009926 + pubmed:27794524 - a(CHEBI:"nicotinic antagonist") decreases sec(a(CHEBI:"gamma-aminobutyric acid")) + path(MESH:"Multiple Sclerosis") increases path(MESH:"Neurodegenerative Diseases") - pmid:17009926 + pubmed:27794524 - a(CHEBI:"nicotinic antagonist") decreases bp(GO:memory) + path(MESH:"Multiple Sclerosis") association path(MESH:Autoimmunity) - pmid:19126755 + pubmed:27794524 - a(HBP:"FK1 antibody") decreases act(a(CHEBI:galanthamine)) + path(MESH:"Multiple Sclerosis") increases path(MESH:"Multiple Sclerosis, Relapsing-Remitting") - pmid:19126755 + pubmed:27794524 - a(HBP:"FK1 antibody") decreases act(a(CHEBI:physostigmine)) + path(MESH:"Multiple Sclerosis") increases a(MESH:"CD8-Positive T-Lymphocytes") - pmid:19126755 + pubmed:27794524 - a(HBP:"FK1 antibody") decreases a(CHEBI:codeine) + path(MESH:"Multiple Sclerosis") decreases act(p(MESH:"Electron Transport Chain Complex Proteins")) - pmid:19126755 + pubmed:27794524 - a(CHEBI:codeine) causesNoChange a(MESH:Cholinesterases) + path(MESH:"Multiple Sclerosis") decreases p(MESH:"Molecular Motor Proteins") - pmid:19126755 + pubmed:27794524 - a(CHEBI:codeine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + path(MESH:"Multiple Sclerosis") directlyDecreases a(PUBCHEM:65065) - pmid:19126755 + pubmed:27794524 - path(MESH:"Sensory Gating") association g(HGNC:CHRNA7) + path(MESH:"Multiple Sclerosis") positiveCorrelation p(HGNC:LINGO1) - pmid:19126755 + pubmed:27956442 - path(MESH:"Sensory Gating") association path(MESH:Schizophrenia) + path(MESH:"Multiple Sclerosis") association path(MESH:Inflammation) - pmid:19126755 + pubmed:27956442 - path(MESH:"Sensory Gating") association path(MESH:Schizophrenia) + path(MESH:"Multiple Sclerosis") association a(MESH:"Motor Neurons") - pmid:19126755 + pubmed:27956442 - path(MESH:"Sensory Gating") association act(p(HGNC:CHRNA7)) + path(MESH:"Multiple Sclerosis") association path(MESH:Sensation) - pmid:19126755 + pubmed:27956442 - a(CHEBI:"kynurenic acid") negativeCorrelation act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + path(MESH:"Multiple Sclerosis") association path(MESH:"Visual Perception") - pmid:19126755 + pubmed:27956442 - a(CHEBI:"kynurenic acid") decreases act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) + path(MESH:"Multiple Sclerosis") association path(MESH:"Autonomic Nervous System") - pmid:19126755 + pubmed:27956442 - a(CHEBI:"kynurenic acid") decreases act(p(HGNC:CHRNA7)) + path(MESH:"Multiple Sclerosis") association path(MESH:"Optic Neuritis") - pmid:19126755 + pubmed:27956442 - a(CHEBI:"kynurenic acid") regulates act(p(HGNC:CHRNA7)) + path(MESH:"Multiple Sclerosis") association path(MESH:"Body Temperature Changes") - pmid:19126755 + pubmed:27956442 - a(CHEBI:"kynurenic acid") regulates act(p(HGNC:CHRNA7)) + path(MESH:"Multiple Sclerosis") association path(NCIT:C28314) - pmid:19126755 + pubmed:27956442 - a(CHEBI:"kynurenic acid") decreases act(p(HGNC:CHRNA7)) + path(MESH:"Multiple Sclerosis") positiveCorrelation path(MESH:"Epstein-Barr Virus Infections") - pmid:19126755 + pubmed:27956442 - a(CHEBI:"kynurenic acid") decreases act(p(HGNC:CHRNA7)) + path(MESH:"Multiple Sclerosis") positiveCorrelation path(MESH:"Infectious Mononucleosis") - pmid:19126755 + pubmed:27956442 - a(CHEBI:"kynurenic acid") decreases act(p(MGI:Chrna7, loc(MESH:Interneurons))) + path(MESH:"Multiple Sclerosis") positiveCorrelation path(MESH:Smoking) - pmid:19126755 + pubmed:22950410 - a(CHEBI:"kynurenic acid") regulates bp(MESH:"Neuronal Plasticity") + path(MESH:"Multiple Sclerosis") association p(HGNC:CRHR1) - pmid:19126755 + pubmed:27288790 - a(CHEBI:"kynurenic acid") regulates bp(GO:"synaptic transmission, cholinergic") + a(CHEBI:"(+)-Tetrandrine") decreases act(p(FPLX:NFkappaB)) - pmid:19126755 + pubmed:27288790 - a(CHEBI:"kynurenic acid") regulates path(MESH:"Cell Survival") + a(CHEBI:"(+)-Tetrandrine") decreases r(HGNC:NOS2) - pmid:19126755 + pubmed:27288790 - a(CHEBI:"kynurenic acid") decreases a(CHEBI:dopamine, loc(GO:"extracellular region")) + a(CHEBI:"(+)-Tetrandrine") decreases r(HGNC:PTGS2) - pmid:19126755 + pubmed:27288790 - a(MESH:Astrocytes) increases a(CHEBI:"kynurenic acid") + a(MESH:Morphine) decreases act(p(FPLX:NFkappaB)) - pmid:23383175 + pubmed:27288790 - a(MESH:Astrocytes) positiveCorrelation a(MESH:Microglia) + a(MESH:Morphine) increases p(FPLX:IKB) - pmid:23383175 + pubmed:27288790 - a(MESH:Astrocytes) negativeCorrelation a(GO:"myelin sheath") + a(PUBCHEM:439378) decreases a(CHEBI:"amyloid-beta polypeptide 42") - pmid:28803412 + pubmed:27288790 - a(MESH:Astrocytes) increases deg(a(HBP:HBP00093)) + a(PUBCHEM:439378) decreases p(FPLX:ERK) - pmid:30108137 + pubmed:27288790 - act(a(MESH:Astrocytes)) increases tloc(a(HBP:"Tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + a(PUBCHEM:439378) decreases p(HGNC:MAPK14) - pmid:26195256 + pubmed:27288790 - a(MESH:Astrocytes) increases sec(p(MESH:Endopeptidases)) + a(PUBCHEM:439378) decreases p(FPLX:NFkappaB) - pmid:26195256 + pubmed:27288790 - a(MESH:Astrocytes) decreases a(CHEBI:"amyloid-beta", loc(MESH:"Extracellular Fluid")) + a(PUBCHEM:3968) decreases p(HGNC:NFKBIA, pmod(go:0006468 ! "protein phosphorylation", Tyr, 42)) - pmid:26195256 + pubmed:27288790 - a(MESH:Astrocytes) increases deg(a(CHEBI:"amyloid-beta")) + a(PUBCHEM:3968) decreases act(p(FPLX:NFkappaB)) - pmid:26195256 + pubmed:27288790 - act(a(MESH:Astrocytes)) decreases a(CHEBI:"amyloid-beta") + a(CHEBI:melatonin) decreases p(HGNC:NFKBIA, pmod(go:0006468 ! "protein phosphorylation", Tyr, 42)) - pmid:26195256 + pubmed:27288790 - act(a(MESH:Astrocytes)) increases a(MESH:Cytokines) + a(CHEBI:melatonin) decreases act(p(FPLX:NFkappaB)) - pmid:18562203 + pubmed:27288790 - act(a(MESH:Astrocytes)) association p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) + a(CHEBI:naproxen) isA a(MESH:"Anti-Inflammatory Agents, Non-Steroidal") - pmid:18562203 + pubmed:27288790 - act(a(MESH:Astrocytes)) association path(MESH:"Plaque, Amyloid") + a(CHEBI:naproxen) decreases r(HGNC:BACE1) - pmid:27314526 + pubmed:27288790 - a(MESH:Astrocytes) increases p(HGNC:NLRP3) + a(CHEBI:naproxen) decreases a(CHEBI:amyloid-beta) - pmid:27314526 + pubmed:27288790 - a(MESH:Astrocytes) increases p(HGNC:TLR4) + a(CHEBI:hydroxytyrosol) decreases act(p(FPLX:NFkappaB)) - pmid:27314526 + pubmed:27288790 - a(MESH:Astrocytes) increases sec(p(HGNC:IL1B)) + a(CHEBI:nicorandil) decreases bp(GO:"apoptotic process") - pmid:19126755 + pubmed:27288790 - a(CHEBI:"L-kynurenine") increases a(CHEBI:"kynurenic acid") + a(CHEBI:nicorandil) decreases path(MESH:"Oxidative Stress") - pmid:19126755 + pubmed:27288790 - a(MESH:Probenecid) decreases a(CHEBI:"kynurenic acid") + a(CHEBI:nicorandil) decreases p(CONSO:APP695) - pmid:19126755 + pubmed:27288790 - bp(GO:"energy homeostasis") regulates a(CHEBI:"kynurenic acid") + a(CHEBI:nicorandil) decreases a(CHEBI:"amyloid-beta polypeptide 42") + + - pmid:19126755 + pubmed:10656250 - act(p(HGNC:AADAT), ma(cat)) increases a(CHEBI:"kynurenic acid") + p(CONSO:APP695) association p(HGNC:BACE1) - pmid:19126755 + pubmed:27288790 - a(CHEBI:kynurenine) increases a(CHEBI:"kynurenic acid") + a(PUBCHEM:6440944) decreases act(p(FPLX:ERK)) - pmid:19126755 + pubmed:27288790 - a(CHEBI:kynurenine) increases a(CHEBI:"3-hydroxykynurenine") + a(PUBCHEM:6440944) decreases p(HGNC:NFKBIA, pmod(go:0006468 ! "protein phosphorylation")) - pmid:19126755 + pubmed:27288790 - a(CHEBI:kynurenine) increases a(CHEBI:"quinolinic acid") + a(PUBCHEM:6440944) decreases p(FPLX:NFkappaB, pmod(go:0006468 ! "protein phosphorylation")) - pmid:19165623 + pubmed:27288790 - a(CHEBI:"quinolinic acid") increases a(CHEBI:"nicotinic acid") + a(PUBCHEM:6440944) decreases act(p(FPLX:NFkappaB)) - pmid:19623258 + pubmed:27288790 - a(CHEBI:"quinolinic acid") association p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + a(PUBCHEM:6440944) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:19623258 + pubmed:27288790 - a(CHEBI:"quinolinic acid") increases p(HGNC:MAPT, pmod(Ph, Ser, 199)) + a(PUBCHEM:6440944) decreases p(HGNC:APP) - pmid:19623258 + pubmed:27288790 - a(CHEBI:"quinolinic acid") increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) + a(PUBCHEM:6440944) decreases a(CHEBI:amyloid-beta) - pmid:19623258 + pubmed:27288790 - a(CHEBI:"quinolinic acid") increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) + a(PUBCHEM:6440944) decreases tloc(a(CHEBI:amyloid-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:19623258 + pubmed:25652642 - a(CHEBI:"quinolinic acid") increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + complex(a(GO:"NF-kappaB complex"), p(HGNC:NFKB1), p(HGNC:RELA), loc(GO:nucleus)) increases act(complex(GO:"NF-kappaB p50/p65 complex")) + + + + + + - pmid:19623258 + pubmed:25652642 - a(CHEBI:"quinolinic acid") increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + bp(GO:"membrane depolarization") increases act(complex(GO:"NF-kappaB complex")) - pmid:19623258 + pubmed:17009926 - a(CHEBI:"quinolinic acid") decreases act(p(FPLX:PPP2)) + bp(GO:"membrane depolarization") increases act(complex(GO:"voltage-gated calcium channel complex")) - pmid:19623258 + pubmed:29428175 - a(CHEBI:"quinolinic acid") decreases act(p(FPLX:PPP1)) + bp(GO:"membrane depolarization") increases complex(GO:"voltage-gated calcium channel complex") - pmid:19623258 + pubmed:26813123 - a(CHEBI:"quinolinic acid") increases act(complex(GO:"NMDA selective glutamate receptor complex")) + bp(GO:"membrane depolarization") regulates act(p(HGNC:CHAT)) - pmid:19623258 + pubmed:26813123 - a(CHEBI:"quinolinic acid") increases r(HGNC:BRCA1) + bp(GO:"membrane depolarization") increases tloc(a(CHEBI:acetylcholine), fromLoc(MESH:"Synaptic Vesicles"), toLoc(GO:"synaptic cleft")) - pmid:19623258 + pubmed:26813123 - a(CHEBI:"quinolinic acid") increases r(HGNC:MYC) + bp(GO:"membrane depolarization") increases complex(a(GO:"plasma membrane"), p(HGNC:SLC5A7)) - pmid:19623258 + pubmed:30697142 - a(CHEBI:"quinolinic acid") increases r(HGNC:WNT1) + bp(GO:"membrane depolarization") increases bp(GO:"calcium ion import") - pmid:19623258 + pubmed:25652642 - a(CHEBI:"quinolinic acid") increases r(HGNC:CCN4) + bp(GO:"synaptic transmission, glutamatergic") increases act(complex(GO:"NF-kappaB complex")) - pmid:19623258 + pubmed:19419557 - a(CHEBI:"quinolinic acid") increases r(HGNC:CDK5) + bp(GO:"synaptic transmission, glutamatergic") association a(CHEBI:"glutamate(2-)") - pmid:19623258 + pubmed:24511233 - a(CHEBI:"quinolinic acid") increases r(HGNC:IL1A) + bp(GO:"synaptic transmission, glutamatergic") association path(MESH:Schizophrenia) - pmid:19623258 + pubmed:26813123 - a(CHEBI:"quinolinic acid") increases r(HGNC:NOS2) + bp(GO:"synaptic transmission, glutamatergic") association bp(GO:cognition) - pmid:19623258 + pubmed:30697142 - a(CHEBI:"quinolinic acid") increases r(HGNC:CEBPB) + bp(GO:"synaptic transmission, glutamatergic") positiveCorrelation bp(GO:cognition) - pmid:19623258 + pubmed:26813123 - a(CHEBI:"quinolinic acid") increases r(HGNC:CSF2) + bp(GO:"synaptic transmission, glutamatergic") association path(CONSO:Neurodegeneration) - pmid:19623258 + pubmed:30106381 - a(CHEBI:"quinolinic acid") increases r(HGNC:LEP) + bp(GO:"synaptic transmission, glutamatergic") positiveCorrelation p(HGNC:ADNP) - pmid:19126755 + pubmed:27013968 - act(p(MGI:Chrna7, loc(MESH:Interneurons))) increases act(a(MESH:"GABAergic Neurons")) + bp(GO:"synaptic transmission, glutamatergic") negativeCorrelation p(HGNC:HTT, pmod(HBP:"CAG repeats")) - pmid:19126755 + pubmed:30988501 - p(MGI:Chrna7) negativeCorrelation path(MESH:Aging) + bp(GO:"synaptic transmission, glutamatergic") increases path(CONSO:neurotoxicity) - pmid:19293145 + pubmed:25652642 - p(MGI:Chrna7) increases bp(MESH:"Neuronal Outgrowth") + bp(GO:"calmodulin dependent kinase signaling pathway") increases act(complex(GO:"NF-kappaB complex")) - pmid:25514383 + pubmed:25652642 - p(MGI:Chrna7) decreases path(MESH:"Spatial Memory") + bp(GO:"phosphatidylinositol 3-kinase signaling") increases act(complex(GO:"NF-kappaB complex")) - pmid:25881725 + pubmed:19126755 - act(p(MGI:Chrna7)) increases path(MESH:"Spatial Memory") + bp(GO:"phosphatidylinositol 3-kinase signaling") regulates r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:25514383 + pubmed:18986241 - p(MGI:Chrna7) decreases p(MGI:Syp) + bp(GO:"phosphatidylinositol 3-kinase signaling") regulates bp(MESH:"Cell Survival") - pmid:25514383 + pubmed:18986241 - p(MGI:Chrna7) decreases p(MGI:Map2) + bp(GO:"phosphatidylinositol 3-kinase signaling") association p(FPLX:RAS) - pmid:25514383 + pubmed:18986241 - p(MGI:Chrna7) increases p(MGI:Map2) + bp(GO:"phosphatidylinositol 3-kinase signaling") association p(HGNC:IRS1) - pmid:25514383 + pubmed:18986241 - p(MGI:Chrna7) increases a(CHEBI:"amyloid-beta") + bp(GO:"phosphatidylinositol 3-kinase signaling") association p(HGNC:GAB1) - pmid:25514383 + pubmed:22040696 - p(MGI:Chrna7) decreases a(CHEBI:"amyloid-beta") + bp(GO:"phosphatidylinositol 3-kinase signaling") decreases bp(GO:"neuron death") - pmid:25514383 + pubmed:22040696 - p(MGI:Chrna7) increases bp(GO:cognition) + bp(GO:"phosphatidylinositol 3-kinase signaling") increases p(FPLX:CHRN) - pmid:25514383 + pubmed:25652642 - p(MGI:Chrna7) decreases path(MESH:"Cognition Disorders") + complex(complex(GO:"NF-kappaB complex"), p(FPLX:IKB), loc(GO:cytoplasm)) directlyDecreases act(complex(GO:"NF-kappaB complex")) - pmid:25514383 + pubmed:25652642 - p(MGI:Chrna7) increases path(MESH:"Plaque, Amyloid") + p(CONSO:sAPP-beta) positiveCorrelation act(complex(GO:"NF-kappaB complex")) - pmid:27522251 + pubmed:19293145 - p(MGI:Chrna7) decreases path(MESH:"Memory Disorders") + p(CONSO:sAPP-beta) decreases act(a(CHEBI:amyloid-beta)) - pmid:27522251 + pubmed:25652642 - p(MGI:Chrna7) decreases path(MESH:"Memory Disorders") + act(p(HGNC:APOE)) association complex(GO:"NF-kappaB complex") + + + + - pmid:27522251 + pubmed:21769591 - p(MGI:Chrna7) decreases path(MESH:"Cognitive Dysfunction") + p(HGNC:APOE) association path(MESH:"Alzheimer Disease") - pmid:27522251 + pubmed:22159054 - p(MGI:Chrna7) association bp(GO:aging) + p(HGNC:APOE) association path(MESH:"Alzheimer Disease") - pmid:27522251 + pubmed:30106381 - p(MGI:Chrna7) increases a(HBP:HBP00022) + p(HGNC:APOE) increases path(MESH:"Alzheimer Disease") - pmid:25881725 + pubmed:24080518 - act(p(MGI:Chrna7)) increases bp(GO:learning) + p(HGNC:APOE) association a(NIFT:"Cortical Thinning") - pmid:25881725 + pubmed:21504134 - p(MGI:Chrna7) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:APOE) negativeCorrelation a(NIFT:"Cortical Thickness") + + + + - pmid:28901280 + pubmed:22550605 - p(MGI:Chrna7) association act(a(MESH:Epithelium)) + p(HGNC:APOE) increases a(NIFT:"Grey matter atrophy") - pmid:21482353 + pubmed:19293145 - a(MESH:"GABAergic Neurons") positiveCorrelation a(HBP:"alpha-4 beta-2 nAChR") + p(HGNC:APOE) association bp(GO:"lipid metabolic process") - pmid:19126755 + pubmed:19293145 - bp(MESH:"Neuronal Plasticity") association act(p(FPLX:CREB)) + p(HGNC:APOE) association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + + - pmid:19126755 + pubmed:21718217 - bp(MESH:"Neuronal Plasticity") association act(p(HGNC:MAPK1)) + p(HGNC:APOE) increases a(CHEBI:"high-density lipoprotein") - pmid:24760868 + pubmed:21718217 - bp(MESH:"Neuronal Plasticity") association tloc(p(HGNC:MAPT), fromLoc(GO:"dendritic shaft"), toLoc(GO:synapse)) + p(HGNC:APOE) increases deg(a(CHEBI:amyloid-beta)) - pmid:28420982 + pubmed:21718217 - bp(MESH:"Neuronal Plasticity") increases tloc(p(HGNC:MAPT), fromLoc(GO:cell), toLoc(GO:cell)) + act(p(HGNC:APOE)) increases deg(a(CHEBI:amyloid-beta)) - pmid:28420982 + pubmed:26195256 - bp(MESH:"Neuronal Plasticity") association a(HBP:"Tau aggregates") + act(p(HGNC:APOE)) regulates a(CHEBI:amyloid-beta) - pmid:19126755 + pubmed:26195256 - a(MESH:"Mossy Fibers, Hippocampal") increases a(CHEBI:"glutamate(2-)", loc(MESH:"Pyramidal Cells")) + tloc(p(HGNC:APOE), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Cardiovascular System")) negativeCorrelation tloc(a(CHEBI:amyloid-beta), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Cardiovascular System")) - pmid:19126755 + pubmed:26195256 - a(MESH:"7-chlorothiokynurenic acid") causesNoChange a(CHEBI:dopamine, loc(GO:"extracellular region")) + p(HGNC:APOE) regulates deg(a(CHEBI:amyloid-beta)) - pmid:28901280 + pubmed:30106381 - a(MESH:Acetylcholine) association bp(GO:"cell-cell signaling") + p(HGNC:APOE) association a(PUBCHEM:9832404) - pmid:28901280 + pubmed:31413141 - a(MESH:Acetylcholine) association bp(HBP:"cell population proliferation") + p(HGNC:APOE) association r(DBSNP:rs769449) - pmid:28901280 + pubmed:31413141 - a(MESH:Acetylcholine) association bp(GO:"cell adhesion") + p(HGNC:APOE) causesNoChange p(HGNC:TREM2, frag("?")) + + - pmid:28901280 + pubmed:25652642 - a(MESH:Acetylcholine) association bp(MESH:"Cell Movement") + composite(a(MESH:"amyloid beta-protein (25-35)"), complex(GO:"NF-kappaB complex")) increases tloc(p(HGNC:TNF), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:28901280 + pubmed:25652642 - a(MESH:Acetylcholine) association bp(GO:"secretion by cell") + composite(a(MESH:"amyloid beta-protein (25-35)"), complex(GO:"NF-kappaB complex")) increases tloc(p(HGNC:NGF), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:28901280 + pubmed:25652642 - a(MESH:Acetylcholine) association bp(MESH:"Cell Survival") + composite(a(MESH:"amyloid beta-protein (25-35)"), complex(GO:"NF-kappaB complex")) increases tloc(p(HGNC:BDNF), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + - pmid:28901280 + pubmed:25652642 - a(MESH:Acetylcholine) association bp(MESH:Apoptosis) + a(MESH:"amyloid beta-protein (25-35)") increases act(complex(GO:"NF-kappaB complex")) + + - pmid:28901280 + pubmed:26551702 - a(MESH:Acetylcholine) association bp(MESH:"Autocrine Communication") + act(p(HGNC:NGF)) increases act(p(FPLX:NFkappaB)) + + - pmid:28901280 + pubmed:19126755 - a(MESH:Acetylcholine) association bp(MESH:"Paracrine Communication") + act(p(HGNC:NGF)) increases bp(GO:"MAPK cascade") - pmid:28901280 + pubmed:18986241 - a(MESH:Acetylcholine) association bp(HBP:"juxtacrine signaling") + act(p(HGNC:NGF)) increases bp(GO:"MAPK cascade") - pmid:28901280 + pubmed:23393546 - a(MESH:Acetylcholine) decreases path(MESH:Inflammation) + p(HGNC:NGF) increases bp(GO:"MAPK cascade") - pmid:28901280 + pubmed:19126755 - a(MESH:Acetylcholine) increases path(MESH:Neoplasms) + act(p(HGNC:NGF)) increases complex(p(HGNC:JUN), p(HGNC:SP1)) + + - pmid:28901280 + pubmed:19126755 - a(MESH:Acetylcholine) increases act(complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9))) + p(HGNC:NGF) regulates r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:28901280 + pubmed:18986241 - a(MESH:Acetylcholine) increases act(p(HGNC:CHRNA9)) + p(HGNC:NGF) isA a(MESH:"Nerve Growth Factors") + + - pmid:19126755 + pubmed:18986241 - a(CHEBI:anandamide) association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + p(HGNC:NGF) causesNoChange path(MESH:"Diabetic Neuropathies") - pmid:19126755 + pubmed:18986241 - a(CHEBI:anandamide) association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + p(HGNC:NGF) causesNoChange path(MESH:"AIDS-Associated Nephropathy") - pmid:19126755 + pubmed:18986241 - a(CHEBI:anandamide) association p(HGNC:CNR1) + p(HGNC:NGF) causesNoChange path(MESH:"Alzheimer Disease") - pmid:19126755 + pubmed:18986241 - a(CHEBI:anandamide) association p(HGNC:CNR2) + p(HGNC:NGF) association bp(GO:innervation) - pmid:19126755 + pubmed:18986241 - a(CHEBI:anandamide) association complex(GO:"voltage-gated calcium channel complex") + p(HGNC:NGF) association bp(GO:"neurotransmitter secretion") - pmid:19126755 + pubmed:18986241 - a(CHEBI:anandamide) association p(HGNCGENEFAMILY:"Potassium voltage-gated channels") + p(HGNC:NGF) association bp(GO:"sympathetic nervous system development") - pmid:19126755 + pubmed:18986241 - a(CHEBI:anandamide) association a(MESH:"Receptors, Serotonin") + p(HGNC:NGF) association path(MESH:Cachexia) - pmid:19126755 + pubmed:18986241 - a(CHEBI:anandamide) association p(HGNCGENEFAMILY:"Glutamate ionotropic receptor kainate type subunits") + p(HGNC:NGF) association path(MESH:Hyperalgesia) - pmid:19126755 + pubmed:18986241 - a(CHEBI:anandamide) decreases act(p(HGNC:CHRNA7)) + p(HGNC:NGF) decreases path(MESH:"Cognitive Dysfunction") - pmid:19126755 + pubmed:25652642 - a(CHEBI:anandamide) decreases act(p(HBP:"alpha-4 beta-2 nAChR")) + p(HGNC:GRM5) increases complex(a(GO:"NF-kappaB complex"), a(GO:"NF-kappaB complex"), p(HGNC:REL)) - pmid:19126755 + pubmed:25652642 - a(CHEBI:anandamide) regulates bp(GO:"chemical synaptic transmission, postsynaptic") + p(HGNC:GRM5) increases act(p(HGNC:SOD2)) - pmid:19126755 + pubmed:25652642 - p(HBP:"gamma-secretase") increases a(CHEBI:"amyloid-beta polypeptide 42") + p(HGNC:GRM5) increases act(p(HGNC:BCL2L1)) @@ -66698,2313 +67415,2286 @@

Statements

- pmid:19293145 + pubmed:24653673 - complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7)) decreases act(a(MESH:Bungarotoxins)) + p(HGNC:GRM5) association path(MESH:"Alzheimer Disease") - pmid:17009926 + pubmed:25652642 - complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7)) association path(MESH:"Alzheimer Disease") + complex(a(GO:"NF-kappaB complex"), a(GO:"NF-kappaB complex"), p(HGNC:REL)) decreases act(a(CHEBI:amyloid-beta)) - pmid:25514383 + pubmed:25652642 - complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7)) association path(MESH:"Plaque, Amyloid") + complex(a(GO:"NF-kappaB complex"), p(HGNC:RELA)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:19126755 + pubmed:22236693 - p(HGNC:CNR1) association a(CHEBI:anandamide) + deg(a(MESH:"Cholinergic Neurons")) regulates bp(GO:cognition) - pmid:19126755 + pubmed:19293145 - p(HGNC:CNR2) association a(CHEBI:anandamide) + a(MESH:"Cholinergic Neurons") increases act(p(HGNC:CHAT)) - pmid:19126755 + pubmed:26813123 - a(MESH:"Receptors, Serotonin") association a(CHEBI:anandamide) + act(a(MESH:"Cholinergic Neurons")) increases path(MESH:Attention) - pmid:19126755 + pubmed:26813123 - p(HGNCGENEFAMILY:"Glutamate ionotropic receptor kainate type subunits") association a(CHEBI:anandamide) + a(MESH:"Cholinergic Neurons") increases path(MESH:Attention) - pmid:19126755 + pubmed:26813123 - a(CHEBI:bupropion) decreases act(p(HGNC:CHRNA7)) + a(MESH:"Cholinergic Neurons") positiveCorrelation bp(GO:memory) - pmid:19126755 + pubmed:26813123 - a(CHEBI:bupropion) decreases act(p(HBP:"alpha-4 beta-2 nAChR")) + a(MESH:"Cholinergic Neurons") increases bp(GO:memory) - pmid:19126755 + pubmed:26813123 - a(CHEBI:bupropion) decreases act(p(HBP:"alpha-3 beta-4 nAChR")) + a(MESH:"Cholinergic Neurons") increases bp(GO:"circadian sleep/wake cycle, REM sleep") - pmid:19126755 + pubmed:26813123 - a(CHEBI:bupropion) association path(MESH:"Smoking Cessation") + a(MESH:"Cholinergic Neurons") increases a(CHEBI:acetylcholine) - pmid:28391535 + pubmed:26813123 - a(CHEBI:bupropion) increases act(a(MESH:"Central Nervous System")) + a(MESH:"Cholinergic Neurons") increases a(CHEBI:choline) - pmid:28391535 + pubmed:26813123 - a(CHEBI:bupropion) decreases path(MESH:Depression) + a(MESH:"Cholinergic Neurons") increases tloc(p(HGNC:ACHE), fromLoc(MESH:"Synaptic Vesicles"), toLoc(GO:"synaptic cleft")) - pmid:28391535 + pubmed:26813123 - a(CHEBI:bupropion) decreases act(a(CHEBI:nicotine)) + a(MESH:"Cholinergic Neurons") increases bp(GO:"synaptic transmission, dopaminergic") - pmid:19126755 + pubmed:26813123 - a(MESH:"N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline") decreases act(p(HGNC:CHRNA7)) + a(MESH:"Cholinergic Neurons") decreases path(MESH:Apathy) - pmid:19126755 + pubmed:26813123 - a(MESH:"N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline") decreases act(p(HBP:"alpha-4 beta-2 nAChR")) + a(MESH:"Cholinergic Neurons") decreases path(MESH:Depression) - pmid:19126755 + pubmed:26813123 - a(MESH:"N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline") decreases act(p(HBP:"alpha-3 beta-4 nAChR")) + a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:19126755 + pubmed:26813123 - path(MESH:"Smoking Cessation") association a(CHEBI:bupropion) + a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Parkinson Disease") - pmid:28391535 + pubmed:26813123 - path(MESH:"Smoking Cessation") increases path(MESH:"Irritable Mood") + a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Down Syndrome") - pmid:28391535 + pubmed:26813123 - path(MESH:"Smoking Cessation") increases path(MESH:Anger) + a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") - pmid:28391535 + pubmed:26813123 - path(MESH:"Smoking Cessation") increases path(MESH:"Stress, Psychological") + a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Supranuclear Palsy, Progressive") - pmid:28391535 + pubmed:26813123 - path(MESH:"Smoking Cessation") increases path(MESH:Anxiety) + a(MESH:"Cholinergic Neurons") negativeCorrelation path(MESH:"Olivopontocerebellar Atrophies") - pmid:28391535 + pubmed:26813123 - path(MESH:"Smoking Cessation") increases path(MESH:"Sleep Wake Disorders") + a(MESH:"Cholinergic Neurons") association act(p(HGNC:CHRM1)) - pmid:28391535 + pubmed:26979166 - path(MESH:"Smoking Cessation") increases path(MESH:Depression) + a(MESH:"Cholinergic Neurons") increases complex(CONSO:"alpha-7 beta-2 nAChR") - pmid:28391535 + pubmed:28901280 - path(MESH:"Smoking Cessation") increases path(MESH:Craving) + a(MESH:"Cholinergic Neurons") increases a(MESH:Acetylcholine) + + - pmid:28391535 + pubmed:25652642 - path(MESH:"Smoking Cessation") decreases bp(GO:cognition) + bp(GO:"positive regulation of advanced glycation end-product receptor activity") increases act(a(MESH:Microglia)) - pmid:28391535 + pubmed:25652642 - path(MESH:"Smoking Cessation") decreases path(MESH:Attention) + bp(GO:"peroxisome proliferator activated receptor signaling pathway") increases act(a(MESH:Microglia)) - pmid:28391535 + pubmed:27299292 - path(MESH:"Smoking Cessation") increases path(MESH:Appetite) + bp(GO:"peroxisome proliferator activated receptor signaling pathway") regulates act(p(HGNC:TFEB)) - pmid:26813123 + pubmed:27299292 - p(FPLX:PKA) increases p(FPLX:CHRN, pmod(Ph)) + bp(GO:"peroxisome proliferator activated receptor signaling pathway") regulates bp(GO:"lipid catabolic process") - pmid:24653673 + pubmed:25652642 - p(FPLX:PKA) increases p(HGNC:PPP2R5A, pmod(Ph, Ser)) + p(MESH:"I-kappa B Proteins", pmod(go:0006468 ! "protein phosphorylation")) increases act(a(MESH:Microglia)) + + - pmid:24653673 + pubmed:25652642 - p(FPLX:PKA) increases p(HGNC:PPP2R5D, pmod(Ph, Ser)) + a(MESH:"HLA-DR Antigens") association path(MESH:"Plaque, Amyloid") - pmid:12428809 + pubmed:25652642 - p(FPLX:PKA) increases p(HGNC:MAPT, pmod(Ph)) + a(MESH:"HLA-DR Antigens") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:29191965 + pubmed:25652642 - p(FPLX:PKA) directlyIncreases p(HGNC:MAPT, pmod(Ph)) + m(HGNC:MIR9-1) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:26195256 + pubmed:25652642 - p(FPLX:PKA) increases p(HGNC:MAPT, pmod(Ph)) + m(HGNC:MIR34A) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:26631930 + pubmed:25652642 - p(FPLX:PKA) directlyIncreases p(HGNC:MAPT, pmod(Ph)) + m(HGNC:MIR125B1) positiveCorrelation path(MESH:"Alzheimer Disease") - - - pmid:22908190 + pubmed:25652642 - act(p(FPLX:PKA)) increases p(HGNC:UCHL1) + m(HGNC:MIR125B1) positiveCorrelation p(HGNC:GFAP) - pmid:30116051 + pubmed:25652642 - act(p(FPLX:PKA), ma(kin)) increases p(HGNC:PSMC5, pmod(Ph, Ser, 120)) + m(HGNC:MIR125B1) positiveCorrelation p(HGNC:VIM) - pmid:25331948 + pubmed:25652642 - p(FPLX:PKA) regulates p(HGNC:GSK3B, pmod(Ph, Ser, 9)) + m(HGNC:MIR125B1) positiveCorrelation p(HGNC:CDKN2A) - pmid:25331948 + pubmed:25652642 - p(FPLX:PKA) increases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) + m(HGNC:MIR146A) positiveCorrelation path(MESH:"Alzheimer Disease") + + + pubmed:24586483 + + m(HGNC:MIR146A) association path(MESH:"Alzheimer Disease") + + - pmid:25331948 + pubmed:24586483 - act(p(FPLX:PKA)) increases p(HGNC:CREB1, pmod(Ph)) + m(HGNC:MIR146A) association path(MESH:"Alzheimer Disease") - pmid:26631930 + pubmed:24586483 - p(FPLX:PKA) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + m(HGNC:MIR146A) regulates path(MESH:Inflammation) - pmid:23001711 + pubmed:24586483 - act(p(FPLX:PKA), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + m(HGNC:MIR146A) association path(CONSO:neuroinflammation) - pmid:17493042 + pubmed:24586483 - p(FPLX:PKA) increases p(HGNC:MAPT, pmod(Ph, Ser, 214)) + m(HGNC:MIR146A) association bp(GO:"amyloid precursor protein metabolic process") - pmid:26692334 + pubmed:25652642 - act(p(FPLX:PKA)) increases p(HGNC:MAPT, pmod(Ph, Ser, 214)) + m(HGNC:MIR155) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:17078951 + pubmed:25652642 - p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 181)) + m(HGNC:MIR339) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:17078951 + pubmed:25652642 - p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 199)) + p(HGNC:VIM) positiveCorrelation m(HGNC:MIR125B1) + + - pmid:17078951 + pubmed:25652642 - p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) + p(HGNC:CDKN2A) positiveCorrelation m(HGNC:MIR125B1) - pmid:17078951 + pubmed:30126037 - p(FPLX:PKA) decreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) + p(HGNC:CDKN2A) association a(GO:"neurofibrillary tangle") - pmid:17078951 + pubmed:30126037 - p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 205)) + p(HGNC:CDKN2A) positiveCorrelation a(GO:"neurofibrillary tangle") - pmid:17078951 + pubmed:30126037 - p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 217)) + p(HGNC:CDKN2A) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") - pmid:17078951 + pubmed:30126037 - p(FPLX:PKA) decreases p(HGNC:MAPT, pmod(Ph, Thr, 217)) + p(HGNC:CDKN2A) association bp(HP:Neurodegeneration) - pmid:17078951 + pubmed:30126037 - p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 231)) + p(HGNC:CDKN2A) association path(MESH:"Cognitive Dysfunction") - pmid:17078951 + pubmed:26551702 - p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) + act(p(HGNC:NFE2L2), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) regulates r(HGNC:NQO1) - pmid:17078951 + pubmed:26551702 - p(FPLX:PKA) increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + act(p(HGNC:NFE2L2), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) regulates r(FPLX:HMOX) - pmid:17078951 + pubmed:26551702 - p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422)) + act(p(HGNC:NFE2L2), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) regulates r(HGNC:GCLM) - pmid:17078951 + pubmed:26551702 - p(FPLX:PKA) negativeCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 404)) + act(p(HGNC:NFE2L2), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) regulates r(HGNC:GCLC) - pmid:17078951 + pubmed:26551702 - p(FPLX:PKA) decreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + act(p(HGNC:NFE2L2), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) regulates r(HGNCGENEFAMILY:"Ferritin subunits") - pmid:17078951 + pubmed:26551702 - p(FPLX:PKA) negativeCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 212)) + p(HGNC:NFE2L2) association bp(GO:"glucose metabolic process") - pmid:17078951 + pubmed:26551702 - p(FPLX:PKA) decreases p(HGNC:MAPT, pmod(Ph, Thr, 212)) + p(HGNC:NFE2L2) regulates bp(GO:"pentose-phosphate shunt") + + + + + + - pmid:17078951 + pubmed:26551702 - p(FPLX:PKA) regulates act(p(HGNC:GSK3B)) + p(HGNC:NFE2L2, loc(MESH:"Cell Nucleus")) increases complex(p(FPLX:MAF), p(HGNC:NFE2L2)) + + - pmid:17078951 + pubmed:26551702 - p(FPLX:PKA) regulates act(p(HGNC:CDK5)) + p(HGNC:NFE2L2, loc(MESH:"Cell Nucleus")) increases complex(g(MESH:"Antioxidant Response Elements"), p(HGNC:NFE2L2)) - pmid:26692334 + pubmed:26551702 - act(p(FPLX:PKA)) increases act(complex(GO:"proteasome complex")) + tloc(p(HGNC:NFE2L2), fromLoc(MESH:"Cell Nucleus"), toLoc(MESH:Cytosol)) increases deg(p(HGNC:NFE2L2)) - pmid:26692334 + pubmed:26551702 - act(p(FPLX:PKA)) decreases a(HBP:"Tau aggregates") + p(HGNC:NFE2L2) decreases path(MESH:"Neurodegenerative Diseases") - pmid:26692334 + pubmed:26551702 - act(p(FPLX:PKA)) increases bp(GO:cognition) + p(HGNC:NFE2L2) positiveCorrelation a(MESH:Cytokines) - pmid:19721446 + pubmed:26551702 - act(p(FPLX:"CAMK2_complex")) increases act(a(CHEBI:nicotine)) + p(HGNC:NFE2L2) decreases act(p(HGNC:IKBKB)) - pmid:23001711 + pubmed:26551702 - p(FPLX:"CAMK2_complex") increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + act(p(HGNC:NFE2L2)) decreases p(HGNC:PTGS2) - pmid:19126755 + pubmed:26551702 - act(p(HGNC:MAPK1)) association bp(MESH:"Neuronal Plasticity") + act(p(HGNC:NFE2L2)) decreases p(HGNC:TNF) - pmid:19126755 + pubmed:26551702 - act(p(HGNC:MAPK1)) association path(MESH:"Tobacco Use Disorder") + act(p(HGNC:NFE2L2)) decreases p(HGNC:NOS2) + + + pubmed:26551702 + + act(p(HGNC:NFE2L2)) increases a(MESH:Glutathione) + + - pmid:19293145 + pubmed:26551702 - act(p(HGNC:MAPK1)) increases bp(GO:"apoptotic process") + p(HGNC:NFE2L2) regulates act(p(FPLX:NFkappaB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) + + + + + + - pmid:28784767 + pubmed:26551702 - act(p(HGNC:MAPK1)) increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) + act(p(HGNC:NFE2L2), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases p(FPLX:HMOX) + + + + - pmid:28784767 + pubmed:26551702 - act(p(HGNC:MAPK1)) increases p(HGNC:MAPT, pmod(Ph, Thr, 205)) + act(p(HGNC:NFE2L2), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases p(HGNC:SQSTM1) + + - pmid:19126755 + pubmed:26551702 - path(MESH:"Tobacco Use Disorder") association act(p(HGNC:MAPK1)) + p(HGNC:NFE2L2) decreases p(HGNC:MAFK) - pmid:19126755 + pubmed:30988501 - path(MESH:"Tobacco Use Disorder") association act(p(FPLX:CREB)) + p(HGNC:NFE2L2) increases act(a(CHEBI:"dimethyl fumarate"), ma(GO:"antioxidant activity")) - pmid:19126755 + pubmed:27794524 - path(MESH:"Tobacco Use Disorder") decreases path(MESH:"Wound Healing") + p(HGNC:NFE2L2) decreases path(MESH:"Oxidative Stress") - pmid:19126755 + pubmed:26445701 - path(MESH:"Tobacco Use Disorder") decreases path(MESH:"Wound Healing") + act(p(HGNC:NFE2L2)) decreases path(MESH:Inflammation) - pmid:19126755 + pubmed:30515821 - path(MESH:"Tobacco Use Disorder") association path(MESH:Infection) + p(HGNC:NFE2L2) increases a(MESH:Mitochondria) - pmid:19126755 + pubmed:22020111 - path(MESH:"Tobacco Use Disorder") association path(MESH:"Skin Aging") + act(p(HGNC:NFE2L2)) increases g(HGNC:HMOX1) - pmid:19126755 + pubmed:22020111 - path(MESH:"Tobacco Use Disorder") increases path(MESH:"Skin Aging") + act(p(HGNC:NFE2L2)) negativeCorrelation path(MESH:"Kidney Diseases") - pmid:19126755 + pubmed:22020111 - path(MESH:"Tobacco Use Disorder") association path(MESH:Neoplasms) + act(p(HGNC:NFE2L2)) negativeCorrelation path(MESH:"Multiple Sclerosis, Relapsing-Remitting") - pmid:19126755 + pubmed:30688256 - path(MESH:"Tobacco Use Disorder") decreases path(MESH:"Colitis, Ulcerative") + p(HGNC:NFE2L2) regulates a(CHEBI:"reactive oxygen species") - pmid:19126755 + pubmed:28148553 - path(MESH:"Tobacco Use Disorder") increases path(MESH:"Crohn Disease") + p(HGNC:NFE2L2) association p(HGNC:EIF2AK3) - pmid:19126755 + pubmed:28148553 - path(MESH:"Tobacco Use Disorder") association path(MESH:"Insulin Resistance") + p(HGNC:NFE2L2) regulates p(HGNC:HMOX1) - pmid:19126755 + pubmed:28148553 - path(MESH:"Tobacco Use Disorder") negativeCorrelation path(MESH:"Parkinson Disease") + p(HGNC:NFE2L2) regulates bp(GO:"iron ion homeostasis") + + - pmid:28445721 + pubmed:21722302 - path(MESH:"Tobacco Use Disorder") association p(FPLX:CHRN) + p(HGNC:NFE2L2) increases a(MESH:"Molecular Chaperones") + + - pmid:21482353 + pubmed:24563850 - path(MESH:"Tobacco Use Disorder") association act(p(FPLX:CHRN)) + p(HGNC:NFE2L2) increases bp(CONSO:Proteostasis) + + - pmid:21482353 + pubmed:29121589 - path(MESH:"Tobacco Use Disorder") positiveCorrelation p(HGNC:CHRNA5, var("?")) + p(HGNC:NFE2L2) partOf complex(p(HGNC:CUL3), p(HGNC:KEAP1), p(HGNC:NFE2L2)) - pmid:21482353 + pubmed:29121589 - path(MESH:"Tobacco Use Disorder") positiveCorrelation p(HGNC:CHRNA5, var("?")) + p(HGNC:NFE2L2) positiveCorrelation p(FPLX:AKT) - pmid:21482353 + pubmed:29121589 - path(MESH:"Tobacco Use Disorder") positiveCorrelation path(MESH:Schizophrenia) + p(HGNC:NFE2L2) negativeCorrelation act(p(HGNC:GSK3B)) - pmid:21482353 + pubmed:24355211 - path(MESH:"Tobacco Use Disorder") positiveCorrelation p(HGNC:CHRNA3, var("?")) + p(HGNC:NFE2L2) increases p(ECCODE:2.5.1.18) - pmid:21482353 + pubmed:26551702 - path(MESH:"Tobacco Use Disorder") positiveCorrelation p(HGNC:CHRNB4, var("?")) + bp(GO:"glucose metabolic process") association p(HGNC:NFE2L2) - pmid:21482353 + pubmed:23300102 - path(MESH:"Tobacco Use Disorder") increases act(a(HBP:"alpha-4 beta-2 nAChR")) + bp(GO:"glucose metabolic process") negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:21787755 + pubmed:21861815 - path(MESH:"Tobacco Use Disorder") association a(HBP:AβOs) + bp(GO:"glucose metabolic process") negativeCorrelation path(DOID:"Alzheimer's disease") - pmid:21787755 + pubmed:30985105 - path(MESH:"Tobacco Use Disorder") association a(HBP:"alpha-4 beta-4 nAChR") + bp(GO:"glucose metabolic process") association p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) - pmid:21787755 + pubmed:26551702 - path(MESH:"Tobacco Use Disorder") association a(HBP:"alpha-6-containing nAChR") + complex(p(HGNC:CUL3), p(HGNC:KEAP1), p(HGNC:RBX1)) regulates p(HGNC:NFE2L2) - pmid:28901280 + pubmed:26551702 - path(MESH:"Tobacco Use Disorder") association g(DNSNP:rs1051730) + complex(p(HGNC:CUL3), p(HGNC:KEAP1), p(HGNC:RBX1)) increases p(HGNC:NFE2L2, pmod(go:0016567 ! "protein ubiquitination")) - - - pmid:19126755 - - bp(GO:"receptor signaling pathway via JAK-STAT") increases act(a(CHEBI:nicotine)) - + - pmid:19126755 + pubmed:29121589 - a(MESH:Skin) association act(a(CHEBI:nicotine)) + p(HGNC:CUL3) partOf complex(p(HGNC:CUL3), p(HGNC:KEAP1), p(HGNC:NFE2L2)) - - - pmid:29626319 - - a(MESH:Skin) decreases a(CHEBI:"amyloid-beta") - + - pmid:29626319 + pubmed:26551702 - a(MESH:Skin) decreases a(CHEBI:"amyloid-beta polypeptide 40") + p(HGNC:KEAP1) increases deg(p(HGNC:NFE2L2)) - pmid:29626319 + pubmed:26551702 - a(MESH:Skin) causesNoChange a(CHEBI:"amyloid-beta polypeptide 42") + p(HGNC:KEAP1) decreases p(HGNC:NFE2L2, loc(MESH:Cytosol)) - pmid:19126755 + pubmed:24563850 - path(MESH:Infection) association path(MESH:"Tobacco Use Disorder") + act(p(HGNC:KEAP1)) increases deg(p(HGNC:NFE2L2)) - - - pmid:19126755 - - path(MESH:"Skin Aging") association path(MESH:"Tobacco Use Disorder") - - - pmid:19126755 + pubmed:26551702 - path(MESH:Neoplasms) association path(MESH:"Tobacco Use Disorder") + p(HGNC:KEAP1) decreases act(p(HGNC:IKBKB)) - pmid:28901280 + pubmed:26551702 - path(MESH:Neoplasms) association p(HGNC:CHRNA7) + p(HGNC:KEAP1) increases complex(p(FPLX:HSP90), p(HGNC:IKBKB)) - pmid:22020111 + pubmed:26551702 - path(MESH:Neoplasms) negativeCorrelation p(HGNC:AIFM2) + p(HGNC:KEAP1) decreases p(HGNC:IKBKB, pmod(go:0006468 ! "protein phosphorylation")) - - - pmid:22020111 - - path(MESH:Neoplasms) negativeCorrelation p(HGNC:GPX3) - + - - - pmid:23454242 - - path(MESH:Neoplasms) association p(FPLX:PPP2) - + - pmid:23454242 + pubmed:29121589 - path(MESH:Neoplasms) negativeCorrelation act(p(FPLX:PPP2)) + p(HGNC:KEAP1) increases complex(p(HGNC:CUL3), p(HGNC:KEAP1), p(HGNC:NFE2L2)) - pmid:22299660 + pubmed:29121589 - path(MESH:Neoplasms) association p(FPLX:PPP2) + p(HGNC:KEAP1) isA p(ECCODE:2.3.2.27) - - - pmid:25784053 - - path(MESH:Neoplasms) association act(p(HGNC:HSF1)) - - - pmid:18930136 + pubmed:26551702 - path(MESH:Neoplasms) negativeCorrelation bp(GO:"cellular protein catabolic process") + p(HGNC:NFE2L2, pmod(go:0016567 ! "protein ubiquitination")) increases deg(p(HGNC:NFE2L2)) - pmid:24563850 + pubmed:29121589 - path(MESH:Neoplasms) increases p(HGNCGENEFAMILY:"Small heat shock proteins") + p(HGNC:NFE2L2, pmod(go:0016567 ! "protein ubiquitination")) regulates deg(p(HGNC:NFE2L2)) - pmid:24563850 + pubmed:26551702 - path(MESH:Neoplasms) association bp(GO:"protein oxidation") + bp(GO:"proteasomal protein catabolic process") increases deg(p(HGNC:NFE2L2)) - pmid:29311797 + pubmed:25031639 - path(MESH:Neoplasms) association p(HGNC:STUB1) + bp(GO:"proteasomal protein catabolic process") negativeCorrelation p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) - pmid:22807490 + pubmed:26631930 - path(MESH:"Colitis, Ulcerative") association path(MESH:Smoking) + bp(GO:"proteasomal protein catabolic process") increases deg(p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination"))) - pmid:23746257 + pubmed:22908190 - bp(GO:"cell cycle") association p(FPLX:HSP90) + bp(GO:"proteasomal protein catabolic process") negativeCorrelation bp(GO:autophagy) - pmid:30126037 + pubmed:22908190 - bp(GO:"cell cycle") association bp(GO:"cellular senescence") + bp(GO:"proteasomal protein catabolic process") decreases a(MESH:Proteins) - pmid:28901280 + pubmed:22908190 - bp(MESH:Apoptosis) association a(MESH:Acetylcholine) + bp(GO:"proteasomal protein catabolic process") association p(HGNC:SQSTM1) - pmid:19126755 + pubmed:24027553 - path(MESH:"Insulin Resistance") association path(MESH:"Tobacco Use Disorder") + bp(GO:"proteasomal protein catabolic process") negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:19126755 + pubmed:26631930 - path(MESH:"Insulin Resistance") increases path(MESH:"Diabetes Mellitus, Type 1") + bp(GO:"proteasomal protein catabolic process") increases deg(p(HGNC:MAPT)) - pmid:21718217 + pubmed:29626319 - path(MESH:"Insulin Resistance") association p(HGNC:PPARGC1A) + bp(GO:"proteasomal protein catabolic process") increases deg(p(HGNC:MAPT)) - pmid:19126755 + pubmed:26631930 - path(MESH:"Genetic Variation") association act(a(CHEBI:nicotine)) + bp(GO:"proteasomal protein catabolic process") increases deg(p(HGNC:MAPT, pmod(go:0070534 ! "protein K63-linked ubiquitination"))) - pmid:19126755 + pubmed:26551702 - a(MESH:"Mice, Inbred Strains") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + complex(p(HGNC:KEAP1), p(HGNC:NFE2L2)) decreases p(HGNC:NFE2L2, loc(MESH:"Cell Nucleus")) - pmid:19126755 + pubmed:26551702 - a(MESH:"Mice, Inbred Strains") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + a(CHEBI:"phenolic radical") decreases complex(p(HGNC:KEAP1), p(HGNC:NFE2L2)) - - - pmid:19126755 - - a(MESH:"Rats, Inbred Strains") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - + - pmid:19126755 + pubmed:26551702 - path(MESH:"Neurofibrillary Tangles") positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:BTRC) increases deg(p(HGNC:NFE2L2)) - pmid:24511233 + pubmed:26551702 - path(MESH:"Neurofibrillary Tangles") biomarkerFor path(MESH:"Alzheimer Disease") + p(HGNC:BTRC) regulates p(HGNC:NFE2L2, loc(MESH:Cytosol)) - pmid:24590577 + pubmed:26551702 - path(MESH:"Neurofibrillary Tangles") association path(MESH:"Alzheimer Disease") + p(HGNC:BTRC) decreases act(p(HGNC:NFE2L2), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) - - - pmid:24027553 - - path(MESH:"Neurofibrillary Tangles") positiveCorrelation path(MESH:"Alzheimer Disease") - - - pmid:24590577 + pubmed:26551702 - path(MESH:"Neurofibrillary Tangles") association bp(GO:"synaptic transmission, cholinergic") + p(HGNC:BTRC) increases deg(p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation"))) - - - pmid:24027553 - - path(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, pmod(Ph)) - - - pmid:24027553 + pubmed:26551702 - path(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, pmod(Ac)) + act(p(HGNC:BTRC)) regulates deg(p(HGNC:NFKBIA)) - pmid:24027553 + pubmed:26551702 - path(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, pmod(HBP:nitration)) + p(HGNC:BTRC) increases act(p(FPLX:NFkappaB)) - - - pmid:24027553 - - path(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, frag("1_?")) - - - pmid:24027553 + pubmed:25546293 - path(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, frag("?_*")) + act(p(HGNC:BTRC), ma(GO:"ubiquitin protein ligase activity")) increases p(HGNC:CTNNB1, pmod(go:0016567 ! "protein ubiquitination")) + + - pmid:24027553 + pubmed:29121589 - path(MESH:"Neurofibrillary Tangles") association a(CHEBI:Thrombin) + p(HGNC:BTRC) increases complex(p(HGNC:BTRC), p(HGNC:CUL1), p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation"))) - pmid:24027553 + pubmed:29121589 - path(MESH:"Neurofibrillary Tangles") association p(HGNC:CAPN2) + p(HGNC:BTRC) isA p(ECCODE:2.3.2.27) - pmid:24027553 + pubmed:17009926 - path(MESH:"Neurofibrillary Tangles") positiveCorrelation act(p(HGNCGENEFAMILY:Caspases)) + bp(GO:"developmental process") association p(FPLX:CHRN) - pmid:24027553 + pubmed:22110360 - path(MESH:"Neurofibrillary Tangles") association act(p(HGNCGENEFAMILY:Caspases)) + bp(GO:"cell population proliferation") association act(p(HGNC:DYRK1A)) - pmid:24027553 + pubmed:26551702 - path(MESH:"Neurofibrillary Tangles") association p(HBP:"Tau C3") + a(CHEBI:lipopolysaccharide) increases act(p(FPLX:NFkappaB)) - pmid:24027553 + pubmed:26551702 - path(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, pmod(Ub)) + a(CHEBI:lipopolysaccharide) increases act(p(FPLX:NFkappaB)) - pmid:19126755 + pubmed:26551702 - path(MESH:"Neurogenic Inflammation") positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:lipopolysaccharide) increases act(p(HGNC:RAC1)) - pmid:19126755 + pubmed:30515821 - p(MGI:Chrnb2) negativeCorrelation path(HBP:Neurodegeneration) + a(CHEBI:lipopolysaccharide) increases act(a(NCIT:C12616)) - pmid:25514383 + pubmed:22807490 - p(MGI:Chrnb2) regulates bp(MESH:Homeostasis) + a(CHEBI:lipopolysaccharide) increases bp(GO:"macrophage activation") - pmid:25514383 + pubmed:23178521 - p(MGI:Chrnb2) increases a(MESH:"Cerebral Cortex") + a(CHEBI:lipopolysaccharide) increases p(HGNC:STAT3, pmod(go:0006468 ! "protein phosphorylation")) - pmid:25514383 + pubmed:23178521 - p(MGI:Chrnb2) increases path(MESH:Attention) + a(CHEBI:lipopolysaccharide) increases p(HGNC:STAT3, pmod(go:0006468 ! "protein phosphorylation")) - pmid:25514383 + pubmed:23178521 - p(MGI:Chrnb2) increases bp(GO:cognition) + a(CHEBI:lipopolysaccharide) increases p(HGNC:STAT3, pmod(go:0006468 ! "protein phosphorylation")) - pmid:27522251 + pubmed:23178521 - p(MGI:Chrnb2) decreases path(MESH:"Memory Disorders") + a(CHEBI:lipopolysaccharide) increases p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation")) - pmid:27522251 + pubmed:23178521 - p(MGI:Chrnb2) increases a(CHEBI:"amyloid-beta") + a(CHEBI:lipopolysaccharide) increases p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation")) - pmid:19126755 + pubmed:23178521 - p(MGI:Chrna4) negativeCorrelation path(MESH:Aging) + a(CHEBI:lipopolysaccharide) increases p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation")) - pmid:19126755 + pubmed:23178521 - a(HBP:"amyloid-beta oligomers") regulates act(p(HGNC:CHRNA7)) + a(CHEBI:lipopolysaccharide) increases p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation")) - pmid:19293145 + pubmed:23178521 - a(HBP:"amyloid-beta oligomers") isA a(CHEBI:"amyloid-beta") + a(CHEBI:lipopolysaccharide) increases p(HGNC:IL1B) + + - pmid:19293145 + pubmed:23178521 - a(HBP:"amyloid-beta oligomers") positiveCorrelation path(MESH:"Cognitive Dysfunction") + a(CHEBI:lipopolysaccharide) increases p(MGI:Il1b) - pmid:19293145 + pubmed:23178521 - a(HBP:"amyloid-beta oligomers") association path(HBP:neurotoxicity) + a(CHEBI:lipopolysaccharide) increases p(MGI:Il1b) - pmid:19293145 + pubmed:23178521 - a(HBP:"amyloid-beta oligomers") directlyIncreases path(HBP:neurotoxicity) + a(CHEBI:lipopolysaccharide) increases p(MGI:Il1b) - pmid:19293145 + pubmed:23178521 - a(HBP:"amyloid-beta oligomers") increases act(p(FPLX:JNK)) + a(CHEBI:lipopolysaccharide) increases p(MGI:Il6) - pmid:19293145 + pubmed:23178521 - a(HBP:"amyloid-beta oligomers") decreases act(p(FPLX:ERK)) + a(CHEBI:lipopolysaccharide) increases p(MGI:Il6) - pmid:26813123 + pubmed:23178521 - a(HBP:"amyloid-beta oligomers") association act(a(GO:"cholinergic synapse")) + a(CHEBI:lipopolysaccharide) increases p(MGI:Il6) - pmid:30145931 + pubmed:23178521 - a(HBP:"amyloid-beta oligomers") increases p(HGNC:MAPT, loc(MESH:Dendrites)) + a(CHEBI:lipopolysaccharide) increases p(MGI:Tnf) - pmid:24760868 + pubmed:23178521 - a(HBP:"amyloid-beta oligomers") increases p(HGNC:MAPT, loc(MESH:"Post-Synaptic Density")) + a(CHEBI:lipopolysaccharide) increases p(MGI:Tnf) - pmid:24760868 + pubmed:23178521 - a(HBP:"amyloid-beta oligomers") decreases p(HGNC:MAPT, loc(GO:synapse)) + a(CHEBI:lipopolysaccharide) increases p(MGI:Tnf) + + - pmid:24760868 + pubmed:23178521 - a(HBP:"amyloid-beta oligomers") decreases p(HGNC:MAPT, loc(GO:synapse)) + a(CHEBI:lipopolysaccharide) increases p(MGI:Stat3, pmod(go:0006468 ! "protein phosphorylation")) - pmid:24760868 + pubmed:25672970 - a(HBP:"amyloid-beta oligomers") increases p(HGNC:MAPT, loc(GO:synapse)) + a(CHEBI:lipopolysaccharide) increases bp(GO:"neuroinflammatory response") - pmid:23528736 + pubmed:19323834 - a(HBP:"amyloid-beta oligomers") increases p(HGNC:MAPT) + a(CHEBI:lipopolysaccharide) decreases p(HGNC:SUMO1) - pmid:30145931 + pubmed:26551702 - a(HBP:"amyloid-beta oligomers") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356)) + complex(p(HGNC:BTRC), p(HGNC:CUL1), p(HGNC:NFKBIA), p(HGNC:SKP1)) increases p(HGNC:NFKBIA, pmod(go:0016567 ! "protein ubiquitination")) - pmid:30145931 + pubmed:26551702 - a(HBP:"amyloid-beta oligomers") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) + complex(p(HGNC:BTRC), p(HGNC:CUL1), p(HGNC:NFKBIA), p(HGNC:SKP1)) increases deg(p(HGNC:NFKBIA)) - - - pmid:17403556 - - a(HBP:"amyloid-beta oligomers") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) - + + + - pmid:17403556 + pubmed:29121589 - a(HBP:"amyloid-beta oligomers") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + p(HGNC:CUL1) partOf complex(p(HGNC:BTRC), p(HGNC:CUL1), p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation"))) + + - pmid:24760868 + pubmed:26551702 - a(HBP:"amyloid-beta oligomers") increases p(HGNC:DLG4) + act(a(MESH:Mitochondria)) increases a(CHEBI:radical) + + - pmid:24760868 + pubmed:30515821 - a(HBP:"amyloid-beta oligomers") decreases p(HGNC:DLG4, loc(GO:synapse)) + a(MESH:Mitochondria) association a(CHEBI:N-methyl-4-phenylpyridinium) - pmid:24760868 + pubmed:22299660 - a(HBP:"amyloid-beta oligomers") increases p(HGNC:GRIA1) + a(MESH:Mitochondria) association p(FPLX:PPP2) - - - pmid:24760868 - - a(HBP:"amyloid-beta oligomers") increases p(HGNC:FYN) - + - pmid:24760868 + pubmed:30126037 - a(HBP:"amyloid-beta oligomers") decreases bp(GO:"actin filament polymerization") + act(a(MESH:Mitochondria)) association bp(GO:"cellular respiration") - pmid:24760868 + pubmed:30837838 - a(HBP:"amyloid-beta oligomers") decreases a(MESH:Actins, loc(GO:synapse)) + a(MESH:Mitochondria) association p(HGNC:CHCHD10) - pmid:24760868 + pubmed:24563850 - a(HBP:"amyloid-beta oligomers") increases complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) + a(CHEBI:radical) association bp(GO:"detection of redox state") - pmid:24760868 + pubmed:24563850 - a(HBP:"amyloid-beta oligomers") increases complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) + a(CHEBI:radical) regulates bp(GO:"intracellular receptor signaling pathway") - pmid:24760868 + pubmed:24563850 - a(HBP:"amyloid-beta oligomers") decreases p(HGNC:MAPT, pmod(Ph, Thr, 205)) + a(CHEBI:radical) regulates bp(MESH:Metabolism) - pmid:24760868 + pubmed:24563850 - a(HBP:"amyloid-beta oligomers") increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + a(CHEBI:radical) decreases a(MESH:Antioxidants) - pmid:24760868 + pubmed:24563850 - a(HBP:"amyloid-beta oligomers") regulates p(HGNC:MAPT, pmod(Ph)) + a(CHEBI:radical) association bp(MESH:"Host-Pathogen Interactions") - pmid:24760868 + pubmed:24563850 - a(HBP:"amyloid-beta oligomers") causesNoChange p(HGNC:MAPT, var("p.S404A"), loc(MESH:"Dendritic Spines")) + a(CHEBI:radical) increases bp(CONSO:"non-enzymatic protein modification") - pmid:23528736 + pubmed:24563850 - a(HBP:"amyloid-beta oligomers") decreases act(p(FPLX:Proteasome)) + a(CHEBI:radical) increases bp(CONSO:misfolding) - pmid:22156579 + pubmed:24563850 - act(a(HBP:"amyloid-beta oligomers")) positiveCorrelation a(MESH:"Microtubule-Associated Proteins") + a(CHEBI:radical) increases bp(MESH:"Protein Carbonylation") - pmid:19126755 + pubmed:27794524 - act(p(HGNC:PTGS1)) increases a(CHEBI:"prostaglandin H2") + path(MESH:"Neurodegenerative Diseases") positiveCorrelation bp(GO:"inflammatory response") - pmid:19126755 + pubmed:27794524 - a(CHEBI:"NS-398") increases p(HGNC:CHRNA4) + path(MESH:"Neurodegenerative Diseases") positiveCorrelation path(MESH:"Tertiary Lymphoid Structures") - pmid:19126755 + pubmed:30061532 - path(MESH:Tremor) positiveCorrelation path(MESH:"Parkinson Disease") + path(MESH:"Neurodegenerative Diseases") positiveCorrelation act(p(HGNC:MTOR)) - pmid:19126755 + pubmed:18986241 - path(MESH:Hypokinesia) positiveCorrelation path(MESH:"Parkinson Disease") + path(MESH:"Neurodegenerative Diseases") association path(MESH:"Alzheimer Disease") - pmid:19126755 + pubmed:22040696 - path(MESH:"Muscle Rigidity") positiveCorrelation path(MESH:"Parkinson Disease") + path(MESH:"Neurodegenerative Diseases") association p(HGNC:CHRNA7) - pmid:21722302 + pubmed:30688256 - path(MESH:"Muscle Rigidity") prognosticBiomarkerFor path(MESH:"Parkinson Disease") + path(MESH:"Neurodegenerative Diseases") association p(HGNC:PINK1) - pmid:17009926 + pubmed:30362565 - path(MESH:"Behavior, Addictive") association p(FPLX:CHRN) + path(MESH:"Neurodegenerative Diseases") association path(MESH:"Huntington Disease") - pmid:19721446 + pubmed:29687724 - path(MESH:Craving) association p(HGNC:CHRNA3) + path(MESH:"Neurodegenerative Diseases") association path(MESH:"Huntington Disease") - pmid:19721446 + pubmed:21722302 - path(MESH:Craving) association p(HGNC:CHRNB4) + path(MESH:"Neurodegenerative Diseases") association bp(GO:autophagy) - pmid:19126755 + pubmed:18930136 - a(HBP:"beta-2-containing nAChR") association a(CHEBI:nicotine) + path(MESH:"Neurodegenerative Diseases") association bp(GO:autophagy) - pmid:19126755 + pubmed:18930136 - a(HBP:"beta-2-containing nAChR") causesNoChange act(a(CHEBI:nicotine)) + path(MESH:"Neurodegenerative Diseases") negativeCorrelation bp(GO:autophagy) - pmid:19126755 + pubmed:21722302 - path(MESH:"Drug Tolerance") association p(HGNC:CHRNB4) + path(MESH:"Neurodegenerative Diseases") association bp(CONSO:"protein aggregation") - pmid:19126755 + pubmed:21722302 - path(MESH:"Drug Tolerance") association a(HBP:"alpha-4-containing nAChR") + path(MESH:"Neurodegenerative Diseases") increases bp(CONSO:"protein aggregation") - pmid:19126755 + pubmed:21722302 - a(HBP:"alpha-4-containing nAChR") association path(MESH:"Drug Tolerance") + path(MESH:"Neurodegenerative Diseases") association bp(MESH:"Endoplasmic Reticulum Stress") - pmid:19293145 + pubmed:21722302 - path(MESH:Death) association path(MESH:"Alzheimer Disease") + path(MESH:"Neurodegenerative Diseases") association path(HP:"Senile plaques") - pmid:19293145 + pubmed:21722302 - a(MESH:"Neurofibrillary Tangles") positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:"Neurodegenerative Diseases") association bp(MESH:"Unfolded Protein Response") - pmid:19293145 + pubmed:30562574 - a(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT) + path(MESH:"Neurodegenerative Diseases") association bp(GO:"chaperone-mediated autophagy") - pmid:14556719 + pubmed:29311797 - a(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT) + path(MESH:"Neurodegenerative Diseases") negativeCorrelation bp(GO:"chaperone-mediated autophagy") - pmid:14556719 + pubmed:30562574 - a(MESH:"Neurofibrillary Tangles") increases p(HGNC:MAPT) + path(MESH:"Neurodegenerative Diseases") association p(HGNC:PARK7) - pmid:27574109 + pubmed:30562574 - a(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT) + path(MESH:"Neurodegenerative Diseases") association p(HGNC:DPYSL2) - pmid:22299660 + pubmed:29758300 - a(MESH:"Neurofibrillary Tangles") association p(FPLX:PPP2C, pmod(Ph)) + path(MESH:"Neurodegenerative Diseases") positiveCorrelation a(CONSO:"protein aggregates") - pmid:21722302 + pubmed:29758300 - a(MESH:"Neurofibrillary Tangles") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + path(MESH:"Neurodegenerative Diseases") association bp(GO:"neuron death") - pmid:21722302 + pubmed:22908190 - a(MESH:"Neurofibrillary Tangles") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + path(MESH:"Neurodegenerative Diseases") association bp(GO:"regulation of endosome size") - pmid:14556719 + pubmed:25784053 - a(MESH:"Neurofibrillary Tangles") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + path(MESH:"Neurodegenerative Diseases") association path(MESH:"Protein Aggregation, Pathological") - pmid:26195256 + pubmed:18930136 - a(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + path(MESH:"Neurodegenerative Diseases") positiveCorrelation p(MESH:Proteins, pmod(CONSO:misfolding)) - pmid:14556719 + pubmed:29024336 - a(MESH:"Neurofibrillary Tangles") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) + path(MESH:"Neurodegenerative Diseases") increases path(MESH:"Proteostasis Deficiencies") - pmid:14556719 + pubmed:29024336 - a(MESH:"Neurofibrillary Tangles") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) + path(MESH:"Neurodegenerative Diseases") increases path(MESH:"Proteostasis Deficiencies") - pmid:27574109 + pubmed:24027553 - a(MESH:"Neurofibrillary Tangles") association a(HBP:"Tau oligomers") + path(MESH:"Neurodegenerative Diseases") association p(HGNCGENEFAMILY:Calpains) - pmid:27574109 + pubmed:23528736 - a(MESH:"Neurofibrillary Tangles") association a(HBP:"phosphatase-activating domain") + path(MESH:"Neurodegenerative Diseases") association p(HGNC:STUB1) - pmid:23528736 + pubmed:23528736 - a(MESH:"Neurofibrillary Tangles") association p(HBP:"UBB+1") + path(MESH:"Neurodegenerative Diseases") association p(HGNC:PRKN) - pmid:19293145 + pubmed:23528736 - a(CHEBI:"EC 3.1.1.8 (cholinesterase) inhibitor") decreases path(MESH:"Alzheimer Disease") + path(MESH:"Neurodegenerative Diseases") association p(HGNC:RNF182) - pmid:16273023 + pubmed:23528736 - a(CHEBI:"NMDA receptor antagonist") association bp(GO:"GO:0035249") + path(MESH:"Neurodegenerative Diseases") association p(HGNC:UCHL1, var("?")) - pmid:16273023 + pubmed:23528736 - a(CHEBI:"NMDA receptor antagonist") decreases act(a(MESH:D009474)) + path(MESH:"Neurodegenerative Diseases") association p(HGNC:ATXN3, var("?")) - pmid:21882945 + pubmed:29191965 - a(CHEBI:"NMDA receptor antagonist") positiveCorrelation bp(GO:cognition) + path(MESH:"Neurodegenerative Diseases") association bp(GO:"aggresome assembly") - - - - - - - pmid:19293145 + pubmed:29311797 - composite(p(HBP:"gamma-secretase"), p(HGNC:APP), p(HGNC:BACE1)) directlyIncreases composite(a(CHEBI:"amyloid-beta polypeptide 40"), a(CHEBI:"amyloid-beta polypeptide 42")) + path(MESH:"Neurodegenerative Diseases") association bp(MESH:Aging) - - - - - pmid:19293145 + pubmed:29311797 - a(HBP:"amyloid-beta fibrils") isA a(CHEBI:"amyloid-beta") + path(MESH:"Neurodegenerative Diseases") negativeCorrelation act(p(FPLX:Proteasome)) - pmid:17403556 + pubmed:26702100 - a(HBP:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(Ph)) + path(MESH:"Neurodegenerative Diseases") association p(HGNC:TFEB) - pmid:17403556 + pubmed:21543606 - a(HBP:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) + bp(GO:myelination) association bp(GO:"regulation of lipid metabolic process") - pmid:17403556 + pubmed:21543606 - a(HBP:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) + bp(GO:myelination) association bp(GO:"regulation of synaptic plasticity") - pmid:17403556 + pubmed:18680553 - a(HBP:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + bp(GO:myelination) positiveCorrelation complex(p(HGNC:FYN), p(HGNC:MAPT)) - pmid:17403556 + pubmed:18680553 - a(HBP:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + bp(GO:myelination) association p(HGNC:MAPT) - pmid:17403556 + pubmed:26751493 - a(HBP:"amyloid-beta fibrils") increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) + bp(GO:myelination) association p(HGNC:FYN) - pmid:19293145 + pubmed:26551702 - a(HBP:"Abeta*56") decreases path(MESH:"Maze Learning") + a(CHEBI:sulforaphane) increases act(p(HGNC:NFE2L2)) - pmid:19293145 + pubmed:26551702 - p(HGNC:BCHE) decreases a(CHEBI:acetylcholine) + a(CHEBI:sulforaphane) increases act(p(HGNC:NFE2L2)) - pmid:18986241 + pubmed:26551702 - act(p(HGNC:BCHE), ma(cat)) directlyIncreases deg(a(CHEBI:acetylcholine)) + a(CHEBI:sulforaphane) increases act(p(HGNC:NFE2L2)) - pmid:18986241 + pubmed:22020111 - p(HGNC:BCHE) association a(MESH:D016874) + a(CHEBI:sulforaphane) increases act(p(HGNC:NFE2L2)) - pmid:18986241 + pubmed:22020111 - p(HGNC:BCHE) association path(MESH:D058225) + a(CHEBI:sulforaphane) increases act(p(HGNC:NFE2L2)) - - - pmid:18986241 + pubmed:22020111 - p(HGNC:BCHE) association path(MESH:D003071) + a(CHEBI:sulforaphane) increases act(p(HGNC:NFE2L2)) - pmid:19293145 + pubmed:22020111 - g(HGNC:CHAT) association path(MESH:"Alzheimer Disease") + a(CHEBI:sulforaphane) increases act(p(HGNC:NFE2L2)) - pmid:19293145 + pubmed:26551702 - g(HGNC:ACHE) association path(MESH:"Alzheimer Disease") + a(CHEBI:sulforaphane) decreases path(MESH:Inflammation) - pmid:19293145 + pubmed:26551702 - a(CHEBI:"dihydro-beta-erythroidine") decreases act(a(CHEBI:nicotine)) + a(CHEBI:sulforaphane) decreases path(MESH:Inflammation) - pmid:19293145 + pubmed:26551702 - a(CHEBI:"dihydro-beta-erythroidine") decreases act(a(CHEBI:nicotine)) + a(CHEBI:sulforaphane) increases bp(GO:"response to oxidative stress") - pmid:19293145 + pubmed:26551702 - a(CHEBI:"dihydro-beta-erythroidine") decreases act(a(HBP:"alpha-4 beta-2 nAChR")) + a(PUBCHEM:9958995) increases act(p(HGNC:NFE2L2)) - pmid:19293145 + pubmed:26551702 - a(CHEBI:"dihydro-beta-erythroidine") decreases bp(MESH:Neuroprotection) + a(PUBCHEM:9958995) increases act(p(HGNC:NFE2L2)) - pmid:17009926 + pubmed:26551702 - a(CHEBI:"dihydro-beta-erythroidine") decreases act(p(HGNC:CHRNB2)) + a(PUBCHEM:9958995) decreases path(MESH:Inflammation) - pmid:17009926 + pubmed:26551702 - a(CHEBI:"dihydro-beta-erythroidine") decreases bp(GO:memory) + a(MESH:Glutathione) decreases a(CHEBI:radical) - pmid:19293145 + pubmed:26551702 - a(CHEBI:Mecamylamine) decreases act(a(CHEBI:nicotine)) + a(MESH:Glutathione) decreases act(p(HGNC:RELA)) - pmid:28391535 + pubmed:26551702 - a(CHEBI:Mecamylamine) decreases act(a(CHEBI:nicotine)) + a(MESH:Glutathione) decreases deg(a(MESH:"Extracellular Matrix")) - pmid:17009926 + pubmed:26551702 - a(CHEBI:Mecamylamine) isA a(CHEBI:"nicotinic antagonist") + a(MESH:Glutathione) negativeCorrelation bp(GO:aging) - pmid:17009926 + pubmed:26551702 - a(CHEBI:Mecamylamine) decreases path(MESH:Attention) + act(p(FPLX:HMOX)) decreases act(p(FPLX:NFkappaB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) - pmid:26813123 + pubmed:26551702 - a(CHEBI:Mecamylamine) decreases act(a(MESH:"Hypothalamo-Hypophyseal System")) + p(FPLX:HMOX) decreases act(p(FPLX:NFkappaB)) - pmid:11230871 + pubmed:26551702 - a(CHEBI:Mecamylamine) decreases bp(GO:cognition) + act(p(FPLX:HMOX)) decreases p(HGNC:SELE) - pmid:19721446 + pubmed:26551702 - a(CHEBI:Mecamylamine) decreases bp(GO:cognition) + act(p(FPLX:HMOX)) decreases p(HGNC:VCAM1) - pmid:28391535 + pubmed:30640040 - a(CHEBI:Mecamylamine) decreases path(MESH:Hypertension) + p(HGNC:SELE) association a(PUBCHEM:9839311) - - - pmid:28391535 - - a(CHEBI:Mecamylamine) increases path(MESH:Tremor) - + - pmid:28391535 + pubmed:30967783 - a(CHEBI:Mecamylamine) increases path(MESH:Confusion) + p(HGNC:VCAM1) increases a(MESH:"Leukocytes, Mononuclear", loc(MESH:"Central Nervous System")) - pmid:28391535 + pubmed:26551702 - a(CHEBI:Mecamylamine) increases path(MESH:Seizures) + complex(p(HGNC:KEAP1), p(HGNC:KPNA6)) increases tloc(p(HGNC:KEAP1), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) + + - pmid:28391535 + pubmed:26551702 - a(CHEBI:Mecamylamine) increases path(MESH:"Bipolar Disorder") + p(HGNC:KPNA6) decreases p(FPLX:HMOX) - pmid:28391535 + pubmed:26551702 - a(CHEBI:Mecamylamine) increases path(MESH:Depression) + p(HGNC:KPNA6) decreases p(HGNC:NQO1) + + - pmid:28391535 + pubmed:26551702 - a(CHEBI:Mecamylamine) decreases path(MESH:Smoking) + act(complex(p(HGNC:CREBBP), p(HGNC:EP300))) increases act(p(HGNC:NFE2L2)) - pmid:28391535 + pubmed:26551702 - a(CHEBI:Mecamylamine) decreases act(a(MESH:"Receptors, Nicotinic")) + act(complex(p(HGNC:CREBBP), p(HGNC:EP300)), ma(GO:"histone acetyltransferase activity")) increases bp(GO:"histone acetylation") - pmid:28391535 + pubmed:26551702 - a(CHEBI:Mecamylamine) decreases act(a(MESH:"Receptors, Nicotinic")) + act(complex(p(HGNC:CREBBP), p(HGNC:EP300)), ma(GO:"histone acetyltransferase activity")) increases p(HGNC:NFE2L2, pmod(go:0006473 ! "protein acetylation")) - pmid:23038257 + pubmed:26551702 - bp(GO:"intracellular receptor signaling pathway") association p(HGNC:CHRNA4) + act(complex(p(HGNC:CREBBP), p(HGNC:EP300)), ma(GO:"histone acetyltransferase activity")) increases p(HGNC:RELA, pmod(go:0006473 ! "protein acetylation")) @@ -69013,533 +69703,506 @@

Statements

- - - pmid:19293145 - - a(MESH:Bungarotoxins) decreases act(a(CHEBI:"amyloid-beta")) - - - pmid:19293145 + pubmed:25031639 - a(MESH:Bungarotoxins) decreases complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) + p(HGNC:CREBBP) increases p(HGNC:MAPT, frag("?"), pmod(go:0006473 ! "protein acetylation", Lys, 18)) - pmid:19293145 + pubmed:29661268 - act(a(MESH:Bungarotoxins)) decreases p(HGNC:MAPT, pmod(Ph)) + act(p(HGNC:CREBBP), ma(GO:"acetyltransferase activity")) increases p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) - pmid:23038257 + pubmed:22530628 - a(MESH:Bungarotoxins) decreases bp(GO:"neuromuscular synaptic transmission") + p(HGNC:CREBBP) increases bp(MESH:"Neuronal Plasticity") - pmid:23038257 + pubmed:22530628 - a(MESH:Bungarotoxins) decreases act(a(MESH:"Electric Organ")) + p(HGNC:CREBBP) increases bp(GO:cognition) - pmid:23038257 + pubmed:30697142 - a(MESH:Bungarotoxins) decreases act(a(CHEBI:decamethonium)) + act(p(HGNC:CREBBP), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases bp(GO:cognition) - pmid:25514383 + pubmed:22530628 - a(MESH:Bungarotoxins) decreases complex(a(CHEBI:"amyloid-beta"), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + p(HGNC:CREBBP) increases bp(GO:"learning or memory") - - - - - pmid:19293145 + pubmed:22530628 - composite(a(CHEBI:"3',5'-cyclic AMP"), p(FPLX:PKC)) regulates act(a(CHEBI:nicotine)) + act(p(HGNC:CREBBP)) increases bp(MESH:"Cell Survival") - pmid:19293145 + pubmed:31248781 - act(a(CHEBI:ethanol)) increases path(HBP:neurotoxicity) + p(HGNC:CREBBP) regulates bp(MESH:"Cell Survival") - pmid:19293145 + pubmed:31248781 - a(MESH:Serum) decreases bp(GO:"cell death") + p(HGNC:CREBBP) association bp(MESH:"Cell Survival") - pmid:30985105 + pubmed:22530628 - a(CHEBI:glucose) positiveCorrelation p(MESH:Proteins, pmod(HBP:"O-GlcNAcylation")) + act(p(HGNC:CREBBP)) increases p(HGNC:ARC) - pmid:19293145 + pubmed:22530628 - a(CHEBI:thapsigargin) increases bp(GO:"cell death") + p(HGNC:CREBBP) increases p(HGNC:ARC) - pmid:19293145 + pubmed:31248781 - a(CHEBI:thapsigargin) decreases bp(GO:"sarcoplasmic reticulum calcium ion transport") + p(HGNC:CREBBP) regulates act(a(MESH:Neurons)) - pmid:21722302 + pubmed:31248781 - a(CHEBI:thapsigargin) increases bp(GO:autophagy) + p(HGNC:CREBBP) association bp(GO:"neurotrophin signaling pathway") - pmid:29024336 + pubmed:31248781 - a(CHEBI:thapsigargin) increases bp(GO:"response to endoplasmic reticulum stress") + p(HGNC:CREBBP) association bp(CONSO:"PI3K-Akt signaling pathway") - pmid:19293145 + pubmed:31248781 - act(a(CHEBI:"L-glutamate(2-)")) increases path(HBP:neurotoxicity) + p(HGNC:CREBBP) association bp(MESH:Neuroprotection) - pmid:19293145 + pubmed:31248781 - act(a(CHEBI:"L-glutamate(2-)")) increases path(HBP:neurotoxicity) + p(HGNC:CREBBP) directlyIncreases p(HGNCGENEFAMILY:Neurotrophins) - pmid:19293145 + pubmed:31248781 - a(CHEBI:"N-methyl-4-phenylpyridinium") increases path(HBP:neurotoxicity) + p(HGNC:CREBBP) directlyIncreases act(p(HGNCGENEFAMILY:Neurotrophins)) - pmid:26813123 + pubmed:31248781 - bp(HBP:Neurodegeneration) negativeCorrelation bp(GO:memory) + p(HGNC:CREBBP) directlyIncreases p(HGNC:BDNF) - pmid:26813123 + pubmed:31248781 - bp(HBP:Neurodegeneration) association bp(GO:"synaptic transmission, glutamatergic") + p(HGNC:CREBBP) directlyIncreases p(HGNC:NTRK2) - - - pmid:26813123 - - bp(HBP:Neurodegeneration) association bp(GO:"synaptic transmission, cholinergic") - + - pmid:18986241 + pubmed:30697142 - bp(HBP:Neurodegeneration) association path(MESH:D060825) + p(HGNC:CREBBP) decreases bp(GO:"programmed cell death") + + - pmid:19293145 + pubmed:20556492 - act(a(MESH:"Vagus Nerve")) increases act(p(HGNC:CHRNA7)) + act(p(HGNC:CREBBP), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) negativeCorrelation complex(p(HGNC:CREBBP), p(HGNC:HTT, pmod(CONSO:"CAG repeats")), p(HGNC:TAF4)) - - - pmid:19293145 - - act(p(HGNC:FAS)) increases bp(GO:"programmed cell death") - + + + - pmid:23702978 + pubmed:14556719 - act(p(HGNC:FAS)) increases act(p(HGNC:IL1B)) + p(HGNC:CREBBP) association a(MESH:"Inclusion Bodies") - pmid:23702978 + pubmed:26631930 - act(p(HGNC:FAS)) increases act(p(HGNC:CASP8)) + p(HGNC:CREBBP) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys)) + + - pmid:19293145 + pubmed:28760828 - bp(GO:"negative regulation of apoptotic process") association a(CHEBI:nicotine) + p(HGNC:EP300) causesNoChange p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 290)) - pmid:19293145 + pubmed:20869593 - p(FPLX:SRC) increases act(a(CHEBI:nicotine)) + act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 290)) - pmid:17009926 + pubmed:28760828 - act(p(FPLX:SRC), ma(kin)) increases p(HGNC:CHRNA7, pmod(Ph)) + act(p(HGNC:EP300)) association p(CONSO:"Tau aggregates") - pmid:22040696 + pubmed:25031639 - act(p(FPLX:SRC), ma(kin)) increases p(FPLX:CHRN, pmod(Ph, Tyr)) + p(HGNC:EP300) positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) - pmid:22040696 + pubmed:26390242 - act(p(FPLX:SRC), ma(kin)) increases p(FPLX:CHRN, pmod(Ph, Tyr)) + act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) - pmid:19293145 + pubmed:29661268 - a(MESH:"Nicotinic Antagonists") decreases bp(MESH:Neuroprotection) + act(p(HGNC:EP300), ma(GO:"acetyltransferase activity")) increases p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) - - - - - - - pmid:19293145 + pubmed:26631930 - p(HGNC:FYN) association p(HGNC:MAPT, pmod(Ph)) + p(HGNC:EP300) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys)) - pmid:18680553 + pubmed:11691934 - p(HGNC:FYN) increases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:EP300) increases p(FPLX:"Histone_H4", pmod(go:0006473 ! "protein acetylation")) - pmid:19293145 + pubmed:20869593 - p(HGNC:FYN) increases bp(GO:cognition) + act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 163)) - pmid:19293145 + pubmed:20869593 - p(HGNC:FYN) increases act(p(FPLX:PI3K)) + act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 174)) - pmid:19293145 + pubmed:20869593 - p(HGNC:FYN) increases p(HGNC:AGAP2, pmod(Ph)) + act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 180)) - pmid:19293145 + pubmed:20869593 - p(HGNC:FYN) decreases bp(GO:"apoptotic process") + act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 254)) - pmid:19293145 + pubmed:20869593 - p(HGNC:FYN) association bp(MESH:Neuroprotection) + act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 274)) - pmid:19293145 + pubmed:20869593 - p(HGNC:FYN) increases bp(MESH:Neuroprotection) + act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) - pmid:19293145 + pubmed:20869593 - p(HGNC:FYN) association act(a(CHEBI:"amyloid-beta")) + act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 281)) - pmid:19293145 + pubmed:20869593 - p(HGNC:FYN) increases complex(p(HGNC:FYN), p(HGNC:PTK2)) + act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 298)) - pmid:19293145 + pubmed:20869593 - p(HGNC:FYN) increases p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors", pmod(Ph)) + act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 317)) - pmid:19293145 + pubmed:20869593 - p(HGNC:FYN) increases p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors", pmod(Ph)) + act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 321)) - pmid:24760868 + pubmed:20869593 - p(HGNC:FYN) positiveCorrelation bp(GO:"long-term synaptic potentiation") + act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 331)) - pmid:30640040 + pubmed:20869593 - p(HGNC:FYN) association a(PUBCHEM:4878) + act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 352)) - pmid:29191965 + pubmed:20869593 - p(HGNC:FYN) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr)) + act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 369)) - pmid:26751493 + pubmed:20869593 - p(HGNC:FYN) association p(HBP:"projection domain") + act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 370)) - pmid:26631930 + pubmed:20869593 - p(HGNC:FYN) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 18)) + act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 383)) - pmid:17493042 + pubmed:20869593 - p(HGNC:FYN) increases p(HGNC:MAPT, pmod(Ph, Tyr, 18)) + act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 385)) - pmid:26631930 + pubmed:20869593 - p(HGNC:FYN) increases p(HGNC:GRIN2B, pmod(Ph)) + act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 395)) - pmid:18680553 + pubmed:26551702 - p(HGNC:FYN) association p(HGNC:MAPT) + bp(GO:"histone acetylation") increases bp(GO:"chromatin disassembly") - pmid:18680553 + pubmed:27807169 - p(HGNC:FYN) association p(HGNC:MAPT, frag("223_226")) + bp(GO:"histone acetylation") increases p(RGD:Cdk5r2) - pmid:18680553 + pubmed:26551702 - p(HGNC:FYN) increases complex(p(HGNC:FYN), p(HGNC:MAPT)) + bp(GO:"chromatin disassembly") increases bp(GO:"mRNA transcription") - pmid:26751493 + pubmed:27013968 - p(HGNC:FYN) association bp(GO:myelination) + bp(GO:"mRNA transcription") negativeCorrelation p(HGNC:HTT, pmod(HBP:"CAG repeats")) - - - - - pmid:19293145 + pubmed:26551702 - complex(p(FPLX:AKT), p(HGNC:AGAP2)) increases act(p(FPLX:AKT)) + p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation", Ser, 276)) increases complex(p(HGNC:CREBBP), p(HGNC:NFE2L2)) - - - pmid:19293145 + pubmed:26551702 - p(MGI:Fyn) decreases bp(MESH:Neuroprotection) + complex(p(FPLX:HDAC), p(HGNC:RELA)) increases bp(GO:"histone deacetylation") @@ -69548,244 +70211,227 @@

Statements

- pmid:18096814 + pubmed:30640040 - p(MGI:Fyn) negativeCorrelation a(CHEBI:"2-bromohexadecanoic acid") + act(p(FPLX:HDAC)) decreases a(CONSO:"Tau aggregates") - pmid:18096814 + pubmed:30640040 - p(MGI:Fyn) regulates tloc(p(MGI:Mapt), fromLoc(GO:cytoplasm), toLoc(GO:"membrane raft")) + p(FPLX:HDAC) association a(PUBCHEM:9865515) - pmid:25125464 + pubmed:27550730 - p(MGI:Fyn) positiveCorrelation a(GO:"neuron spine") + act(p(FPLX:HDAC)) negativeCorrelation act(p(FPLX:CREB)) - pmid:25125464 + pubmed:21427723 - p(MGI:Fyn) increases p(MGI:Grin2b, pmod(Ph, Tyr, 1472)) + act(p(FPLX:HDAC)) decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) - pmid:25125464 + pubmed:26551702 - act(p(MGI:Fyn)) increases p(MGI:Mapt, pmod(Ph, Ser, 202)) + act(p(HGNC:RAC1)) increases act(p(HGNC:NFE2L2), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) - pmid:25125464 + pubmed:26551702 - act(p(MGI:Fyn)) increases p(MGI:Mapt, pmod(Ph, Thr, 205)) + p(HGNC:RAC1) increases p(HGNC:NFE2L2) - pmid:19293145 + pubmed:27796283 - p(HGNC:JAK2) increases bp(MESH:Neuroprotection) + act(p(HGNC:RAC1)) regulates bp(GO:"dendritic spine development") - pmid:19293145 + pubmed:26551702 - p(HGNC:JAK2) association bp(MESH:Neuroprotection) + complex(p(FPLX:HSP90), p(HGNC:IKBKB)) increases deg(p(HGNC:IKBKB)) - - - pmid:19293145 - - p(HGNC:JAK2) increases act(a(CHEBI:nicotine)) - - - pmid:19293145 + pubmed:22110360 - act(p(HGNC:JAK2)) regulates act(a(CHEBI:nicotine)) + p(FPLX:HSP90) directlyDecreases act(p(HGNC:MAP3K5)) - pmid:19293145 + pubmed:25437566 - p(HGNC:JAK2) association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + act(p(FPLX:HSP90)) association a(CHEBI:ATP) - pmid:19293145 + pubmed:25437566 - p(HGNC:JAK2) association act(p(HGNC:STAT3)) + p(FPLX:HSP90) decreases a(CHEBI:"amyloid-beta polypeptide 42") - pmid:19293145 + pubmed:25437566 - p(HGNC:JAK2) increases act(p(HGNC:FYN)) + p(FPLX:HSP90) increases bp(GO:"protein folding") - - - - - pmid:19293145 + pubmed:23746257 - complex(p(HGNC:FYN), p(HGNC:MAPT)) increases p(HGNC:MAPT, pmod(Ph)) + act(p(FPLX:HSP90)) increases bp(GO:"protein folding") - pmid:24653673 + pubmed:25784053 - complex(p(HGNC:FYN), p(HGNC:MAPT)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(FPLX:HSP90) regulates bp(GO:"protein folding") - pmid:26631930 + pubmed:27491084 - complex(p(HGNC:FYN), p(HGNC:MAPT)) regulates path(HBP:Excitotoxicity) + p(FPLX:HSP90) association bp(CONSO:Proteostasis) - pmid:18680553 + pubmed:29311797 - complex(p(HGNC:FYN), p(HGNC:MAPT)) positiveCorrelation bp(GO:myelination) + p(FPLX:HSP90) association bp(CONSO:Proteostasis) - pmid:19293145 + pubmed:23746257 - p(HGNC:MAPT, pmod(Ph, Tyr)) association p(HGNC:PTK2, pmod(Ph)) + act(p(FPLX:HSP90)) association bp(GO:"'de novo' protein folding") - pmid:26631930 + pubmed:23746257 - p(HGNC:MAPT, pmod(Ph, Tyr)) increases a(HBP:"Tau aggregates") + act(p(FPLX:HSP90)) association bp(GO:"protein refolding") - - - - - - - pmid:19293145 + pubmed:23746257 - p(HGNC:PTK2, pmod(Ph)) association p(HGNC:MAPT, pmod(Ph, Tyr)) + p(FPLX:HSP90) association bp(GO:"cell cycle") - pmid:19293145 + pubmed:23746257 - p(HGNC:PTK2, pmod(Ph)) decreases act(p(HGNC:PTK2)) + p(FPLX:HSP90) association bp(GO:"steroid hormone mediated signaling pathway") - pmid:19293145 + pubmed:23746257 - p(HGNC:CHRNA7, pmod(Ph)) decreases act(a(CHEBI:acetylcholine)) + p(FPLX:HSP90) association bp(GO:"calcium-mediated signaling") - pmid:23038257 + pubmed:23746257 - p(HGNC:CHRNA7, pmod(Ph)) increases act(a(MESH:"Motor Endplate"), ma(GO:localization)) + p(FPLX:HSP90) association bp(GO:"protein transport") - pmid:17009926 + pubmed:23746257 - p(HGNC:CHRNA7, pmod(Ph)) decreases act(p(HGNC:CHRNA7)) + p(FPLX:HSP90) association bp(GO:"protein secretion") - pmid:19293145 + pubmed:23746257 - a(CHEBI:estradiol) decreases act(a(CHEBI:"amyloid-beta")) + p(FPLX:HSP90) association bp(GO:"immune response") - pmid:19293145 + pubmed:23746257 - a(CHEBI:estradiol) decreases path(HBP:neurotoxicity) + p(FPLX:HSP90) association bp(MESH:"Heat-Shock Response") @@ -69794,237 +70440,237 @@

Statements

- - - pmid:19293145 + pubmed:25784053 - act(p(RGD:Chrna7)) regulates act(a(CHEBI:nicotine)) + p(FPLX:HSP90) isA a(MESH:"Molecular Chaperones") - pmid:19293145 + pubmed:25784053 - act(p(RGD:Chrna7)) decreases act(a(CHEBI:"glutamate(2-)")) + p(FPLX:HSP90) regulates bp(MESH:Proteolysis) - - - - - pmid:19293145 + pubmed:25784053 - composite(p(HGNC:JAK2), p(HGNC:STAT3)) regulates act(p(HGNC:INS)) + act(p(FPLX:HSP90)) decreases act(p(HGNC:HSF1)) - pmid:19293145 + pubmed:24563850 - act(p(HGNC:INS)) association path(MESH:"Alzheimer Disease") + p(FPLX:HSP90) decreases path(MESH:"Protein Aggregation, Pathological") - pmid:26195256 + pubmed:29311797 - p(HGNC:INS) increases a(CHEBI:"amyloid-beta") + p(FPLX:HSP90) regulates path(MESH:"Protein Aggregation, Pathological") - - - pmid:19293145 - - g(HGNC:NIN) association g(HGNC:GSK3B) - + - - - pmid:19293145 - - g(HGNC:GSK3B) association g(HGNC:NIN) - + - pmid:19293145 + pubmed:21882945 - act(p(HGNC:MYC)) increases bp(GO:"apoptotic process") + act(p(FPLX:HSP90)) association a(CHEBI:celastrol) - - - - - pmid:19293145 + pubmed:21882945 - complex(a(CHEBI:nicotine), p(HGNC:CHRNA7)) increases bp(GO:"ERK1 and ERK2 cascade") + p(FPLX:HSP90) increases bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") - pmid:19293145 + pubmed:21882945 - complex(a(CHEBI:nicotine), p(HGNC:CHRNA7)) increases act(p(FPLX:JNK)) + p(FPLX:HSP90) increases bp(GO:"proteasomal protein catabolic process") - pmid:19293145 + pubmed:21882945 - complex(a(CHEBI:nicotine), p(HGNC:CHRNA7)) increases bp(GO:"MAPK cascade") + p(FPLX:HSP90) increases bp(GO:autophagy) - pmid:19293145 + pubmed:21882945 - a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases p(HGNC:MAPK1, pmod(Ph)) + p(FPLX:HSP90) increases act(p(HGNC:STUB1)) + + - pmid:19293145 + pubmed:21882945 - a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases p(HGNC:MAPK3, pmod(Ph)) + p(FPLX:HSP90) increases bp(GO:"protein catabolic process") - pmid:19293145 + pubmed:21882945 - a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") causesNoChange p(HGNC:MAPK14, pmod(Ph)) + p(FPLX:HSP90) increases complex(a(GO:microtubule), p(HGNC:MAPT)) - pmid:19293145 + pubmed:21882945 - a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") causesNoChange p(HGNC:MAPK8, pmod(Ph)) + p(FPLX:HSP90) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:19721446 + pubmed:21882945 - a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases bp(GO:cognition) + p(FPLX:HSP90) regulates p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:19721446 + pubmed:19363271 - a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases path(MESH:"Memory, Episodic") + p(FPLX:HSP90) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:19721446 + pubmed:21882945 - a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases bp(MESH:Neuroprotection) + p(FPLX:HSP90) regulates act(p(HGNC:GSK3B)) + + - pmid:19721446 + pubmed:21882945 - a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") decreases act(a(CHEBI:"amyloid-beta polypeptide 42")) + p(FPLX:HSP90) regulates p(HGNC:MAPT, var("?")) - pmid:19721446 + pubmed:29311797 - a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") decreases bp(MESH:"Cell Survival") + p(FPLX:HSP90) increases p(HGNC:MAPT, var("?")) + + - pmid:19721446 + pubmed:19363271 - a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases bp(MESH:"Sensory Gating") + p(FPLX:HSP90) increases complex(p(FPLX:HSP90), p(HGNC:MAPT)) + + + + + + + + - pmid:19721446 + pubmed:25374103 - a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases bp(MESH:"Sensory Gating") + p(FPLX:HSP90) increases deg(p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) - pmid:19721446 + pubmed:29311797 - a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases act(p(HGNC:CHRNA7)) + p(FPLX:HSP90) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:19721446 + pubmed:25374103 - a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases bp(GO:memory) + p(FPLX:HSP90) increases deg(p(HGNC:MAPT, pmod(CONSO:misfolded))) + + + + + + - pmid:19721446 + pubmed:29311797 - a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases path(MESH:Attention) + p(FPLX:HSP90) regulates a(CONSO:"Tau aggregates") @@ -70032,131 +70678,171 @@

Statements

+ + + + + + + + + + + + + + + + + + + + - pmid:23528736 + pubmed:29311797 - p(HGNC:MAPK8) increases bp(GO:autophagy) + p(FPLX:HSP90) increases act(p(FPLX:Proteasome)) - pmid:23528736 + pubmed:29311797 - p(HGNC:MAPK8) increases p(HGNC:BCL2, pmod(Ph)) + p(FPLX:HSP90) association bp(GO:"chaperone-mediated autophagy") + + + + + + + + + + - pmid:23528736 + pubmed:29311797 - p(HGNC:MAPK8) increases p(HGNC:BCL2L11, pmod(Ph)) + act(p(FPLX:HSP90), ma(GO:"ATPase activity")) increases path(MESH:Tauopathies) - pmid:11943212 + pubmed:19363271 - p(HGNC:MAPK8) increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) + p(FPLX:HSP90) association p(CONSO:"VQIVYK motif") - pmid:19293145 + pubmed:19363271 - a(MESH:"A-582941") increases p(HGNC:MAPK3, pmod(Ph)) + p(FPLX:HSP90) positiveCorrelation bp(GO:"neurofibrillary tangle assembly") - pmid:19293145 + pubmed:20133804 - a(MESH:"A-582941") increases p(HGNC:MAPK1, pmod(Ph)) + p(FPLX:HSP90) association p(HGNC:FKBP4, frag("270_386")) - pmid:19293145 + pubmed:21367866 - a(CHEBI:"SL-327") decreases act(a(MESH:"A-582941")) + act(p(FPLX:HSP90)) positiveCorrelation p(HGNC:CDC37) + + - pmid:19293145 + pubmed:26551702 - act(p(HGNC:NOS1)) increases a(CHEBI:"nitric oxide") + complex(p(HGNC:IKBKB), p(HGNC:KEAP1)) increases p(HGNC:NFKBIA) - + + + pubmed:26551702 + + complex(p(HGNC:IKBKB), p(HGNC:KEAP1)) decreases act(p(FPLX:NFkappaB)) + - pmid:19293145 + pubmed:26551702 - composite(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases bp(GO:"MAPK cascade") + p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation")) increases complex(p(HGNC:BTRC), p(HGNC:NFE2L2)) - pmid:19293145 + pubmed:21722302 - composite(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)") + p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation")) increases r(HGNCGENEFAMILY:"Soluble glutathione S-transferases") - pmid:19293145 + pubmed:21722302 - composite(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases act(p(HGNC:MAPK1)) + p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation")) increases r(HGNCGENEFAMILY:"NADH:ubiquinone oxidoreductase core subunits") - pmid:19293145 + pubmed:21722302 - composite(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases p(FPLX:AKT, pmod(Ph)) + p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation")) increases r(MESH:"Heme Oxygenase-1") - pmid:19293145 + pubmed:21722302 - composite(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases sec(a(CHEBI:dopamine)) + p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation")) increases r(MESH:Glucuronosyltransferase) - - - + + + pubmed:21722302 + + p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation")) increases r(MESH:"Glutamate-Cysteine Ligase") + @@ -70164,258 +70850,280 @@

Statements

- pmid:19293145 + pubmed:29121589 - composite(p(FPLX:ERK), p(FPLX:RAF), p(FPLX:RAS), p(HGNC:MAP2K1)) increases act(a(CHEBI:nicotine)) + p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation")) partOf complex(p(HGNC:BTRC), p(HGNC:CUL1), p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation"))) + + - pmid:19293145 + pubmed:26551702 - act(p(FPLX:RAS)) increases p(HGNC:STAT3) + p(HGNC:SQSTM1) regulates bp(GO:"inflammatory response") - pmid:18986241 + pubmed:26551702 - p(FPLX:RAS) association bp(GO:"GO:0014065") + p(HGNC:SQSTM1) regulates bp(GO:"response to oxidative stress") - pmid:18986241 + pubmed:26551702 - p(FPLX:RAS) association bp(GO:"GO:0043491") + p(HGNC:SQSTM1) increases act(p(HGNC:NFE2L2)) - - - - - pmid:19293145 + pubmed:26551702 - composite(p(FPLX:JAK), p(HGNC:STAT3)) increases p(HGNC:STAT3, pmod(Ph)) + p(HGNC:SQSTM1) increases deg(p(HGNC:KEAP1)) - pmid:19293145 + pubmed:26551702 - act(a(CHEBI:"N-methyl-D-aspartic acid")) increases path(HBP:neurotoxicity) + p(HGNC:SQSTM1) increases p(HGNC:TRAF6, pmod(go:0016567 ! "protein ubiquitination")) - pmid:19293145 + pubmed:26551702 - bp(GO:"calcium-mediated signaling") association act(a(CHEBI:"amyloid-beta")) + p(HGNC:SQSTM1) increases act(p(HGNC:TRAF6)) + + + + - pmid:19293145 + pubmed:22020111 - bp(GO:"calcium-mediated signaling") association bp(MESH:Neuroprotection) + p(HGNC:SQSTM1) increases bp(GO:autophagy) - pmid:19293145 + pubmed:22908190 - bp(GO:"calcium-mediated signaling") association act(p(HGNC:CHRNA7)) + p(HGNC:SQSTM1) increases bp(GO:autophagy) - pmid:19293145 + pubmed:18930136 - bp(GO:"calcium-mediated signaling") association a(CHEBI:nicotine) + p(HGNC:SQSTM1) regulates bp(GO:autophagy) - pmid:19293145 + pubmed:18930136 - bp(GO:"calcium-mediated signaling") association composite(p(HGNC:JAK2), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + p(HGNC:SQSTM1) increases bp(GO:autophagy) - pmid:23746257 + pubmed:18930136 - bp(GO:"calcium-mediated signaling") association p(FPLX:HSP90) + p(HGNC:SQSTM1) increases bp(GO:autophagy) - pmid:25514383 + pubmed:22020111 - bp(GO:"calcium ion transport") negativeCorrelation a(HBP:"alpha-4 beta-2 nAChR") + p(HGNC:SQSTM1) decreases bp(GO:"stress-induced premature senescence") + + - pmid:25514383 + pubmed:29758300 - bp(GO:"calcium ion transport") positiveCorrelation a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") + p(HGNC:SQSTM1) increases deg(p(HGNC:MAPT)) - pmid:21482353 + pubmed:29758300 - bp(GO:"calcium ion transport") association act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + p(HGNC:SQSTM1) decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:19293145 + pubmed:29758300 - a(MESH:"3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole") increases act(p(RGD:Chrna7)) + p(HGNC:SQSTM1) increases p(HGNC:SYP) - pmid:19721446 + pubmed:29758300 - a(MESH:"3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole") association path(MESH:"Attention Deficit Disorder with Hyperactivity") + p(HGNC:SQSTM1) regulates bp(GO:"short-term memory") - pmid:19293145 + pubmed:22908190 - a(CHEBI:"calcium(1+)") decreases act(a(MESH:"3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole")) + p(HGNC:SQSTM1) association bp(GO:"proteasomal protein catabolic process") + + - pmid:19293145 + pubmed:18930136 - p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors") association a(CHEBI:nicotine) + p(HGNC:SQSTM1) regulates bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:19293145 + pubmed:18930136 - act(p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors")) association a(CHEBI:"calcium(2+)") + p(HGNC:SQSTM1) increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - - - pmid:19293145 + pubmed:18930136 - p(HGNCGENEFAMILY:"Ryanodine receptors") association a(CHEBI:nicotine) + p(HGNC:SQSTM1) regulates a(GO:aggresome) - pmid:19293145 + pubmed:18930136 - act(p(HGNCGENEFAMILY:"Ryanodine receptors")) increases bp(GO:"cellular calcium ion homeostasis") + p(HGNC:SQSTM1) association a(GO:"Lewy body") - - - + + + pubmed:18930136 + + p(HGNC:SQSTM1) association a(GO:"neurofibrillary tangle") + - pmid:19293145 + pubmed:18930136 - composite(a(CHEBI:"calcium(2+)"), a(MESH:Calcineurin), p(HGNC:PTPN5)) increases p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits", pmod(Ph)) + p(HGNC:SQSTM1) association a(MESH:"Huntingtin Protein") - pmid:19293145 + pubmed:18930136 - bp(GO:"regulation of cytosolic calcium ion concentration") association path(MESH:"Alzheimer Disease") + p(HGNC:SQSTM1) association p(HGNC:SOD1, var("?")) - + + + pubmed:18930136 + + p(HGNC:SQSTM1) increases deg(p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination"))) + - pmid:19293145 + pubmed:18930136 - composite(a(CHEBI:"amyloid-beta"), complex(p(HGNC:CHRNA3), p(HGNC:CHRNB2))) increases bp(GO:"cellular calcium ion homeostasis") + p(HGNC:SQSTM1) increases bp(GO:"ubiquitin-dependent protein catabolic process") - + + + pubmed:30116051 + + p(HGNC:SQSTM1) association path(MESH:"Frontotemporal Dementia") + - + + + pubmed:30116051 + + p(HGNC:SQSTM1) association path(MESH:"Amyotrophic Lateral Sclerosis") + - pmid:19293145 + pubmed:30837838 - composite(p(HGNC:JAK2), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association bp(GO:"calcium-mediated signaling") + p(HGNC:SQSTM1, loc(GO:"inclusion body")) association path(MESH:"Amyotrophic Lateral Sclerosis") @@ -70426,472 +71134,451 @@

Statements

- pmid:19293145 + pubmed:30837838 - composite(p(HGNC:MAPK14), p(HGNC:MAPK8)) decreases bp(GO:"long-term synaptic potentiation") + p(HGNC:SQSTM1, loc(GO:"inclusion body")) association path(MESH:Autophagy) - pmid:19293145 + pubmed:30837838 - g(HGNC:APOE) increases p(HGNC:APOE) + p(HGNC:SQSTM1, loc(GO:"inclusion body")) association path(MESH:"Frontotemporal Lobar Degeneration") + + - pmid:19293145 + pubmed:26551702 - g(HGNC:APOE) positiveCorrelation path(MESH:"Alzheimer Disease") + complex(p(HGNC:MAFK), p(HGNC:NFE2L2)) regulates act(p(HGNC:RELA), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) + + - pmid:19293145 + pubmed:26551702 - g(HGNC:APOE) association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + p(HGNC:MAFK) increases complex(p(HGNC:CREBBP), p(HGNC:RELA)) - pmid:19293145 + pubmed:26551702 - g(HGNC:APOE) negativeCorrelation p(HGNC:CHAT) + p(HGNC:MAFK) increases a(MESH:Cytokines) - pmid:19293145 + pubmed:26551702 - g(HGNC:APOE) negativeCorrelation act(a(CHEBI:tacrine)) + complex(p(HGNC:CREBBP), p(HGNC:RELA)) increases p(HGNC:RELA) - pmid:19293145 + pubmed:26551702 - g(HGNC:APOE) causesNoChange complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) + a(CHEBI:cinnamate) decreases path(MESH:Inflammation) - pmid:19293145 + pubmed:26551702 - bp(GO:"lipid metabolic process") association p(HGNC:APOE) + a(CHEBI:cinnamate) increases act(p(HGNC:NFE2L2)) - pmid:19293145 + pubmed:26551702 - bp(GO:"lipid metabolic process") association p(HGNC:CHRNA4) + a(CHEBI:cinnamate) increases bp(GO:"response to oxidative stress") - pmid:19293145 + pubmed:30962309 - p(HGNC:CHRNA7, var("p.Trp55Ala")) decreases complex(p(HGNC:APOE), p(HGNC:CHRNA7)) + path(MESH:Infection) increases complex(MESH:Inflammasomes) - - - - - pmid:19293145 + pubmed:26445701 - act(a(CHEBI:carbachol)) decreases a(CHEBI:phosphatidylinositol) + path(MESH:Infection) decreases path(MESH:"Autoimmune Diseases") - pmid:24590577 + pubmed:26445701 - a(CHEBI:carbachol) increases act(p(HGNC:CHRM1)) + path(MESH:Infection) decreases path(HP:Allergy) - pmid:26751493 + pubmed:19126755 - a(CHEBI:phosphatidylinositol) association p(HBP:"projection domain") + path(MESH:Infection) association path(MESH:"Tobacco Use Disorder") - pmid:19293145 + pubmed:30988501 - p(HBP:"APOE e4") decreases act(a(CHEBI:carbachol), ma(MESH:Hydrolysis)) + path(MESH:Infection) increases path(MESH:"Illness Behavior") - pmid:26195256 + pubmed:30988501 - p(HBP:"APOE e4") increases path(MESH:"Alzheimer Disease") + path(MESH:Infection) decreases bp(GO:cognition) - pmid:26195256 + pubmed:30988501 - p(HBP:"APOE e4") regulates bp(GO:"establishment of blood-brain barrier") + path(MESH:Infection) decreases bp(GO:cognition) - pmid:26195256 + pubmed:30988501 - p(HBP:"APOE e4") increases act(p(HGNC:PPIA)) + path(MESH:Infection) decreases bp(GO:cognition) - pmid:26195256 + pubmed:30988501 - p(HBP:"APOE e4") negativeCorrelation bp(HBP:"perivascular drainage pathways") + path(MESH:Infection) increases path(MESH:"Signs and Symptoms") - pmid:26195256 + pubmed:30988501 - p(HBP:"APOE e4") positiveCorrelation a(CHEBI:"amyloid-beta") + path(MESH:Infection) increases path(MESH:Inflammation) - pmid:19293145 + pubmed:30988501 - a(CHEBI:wortmannin) decreases act(a(CHEBI:estrogen)) + path(MESH:Infection) increases path(DOID:"learning disability") - pmid:30145931 + pubmed:30988501 - a(CHEBI:wortmannin) decreases bp(GO:autophagy) + path(MESH:Infection) decreases bp(GO:"learning or memory") - pmid:30145931 + pubmed:30988501 - a(CHEBI:wortmannin) increases p(HGNC:MAPT) + path(MESH:Infection) decreases path(MESH:Attention) - pmid:30145931 + pubmed:30988501 - a(CHEBI:wortmannin) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356)) + path(MESH:Infection) increases path(DOID:"autism spectrum disorder") - pmid:30145931 + pubmed:30988501 - a(CHEBI:wortmannin) causesNoChange p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) + path(MESH:Infection) increases path(MESH:Recurrence) - - - - - pmid:19293145 + pubmed:30962309 - composite(a(CHEBI:nicotine), complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) decreases sec(a(CHEBI:"amyloid-beta")) + complex(MESH:Inflammasomes) increases deg(p(HGNC:IL1B)) - pmid:19293145 + pubmed:30962309 - composite(a(CHEBI:nicotine), complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) causesNoChange r(HGNC:APP) + complex(MESH:Inflammasomes) increases deg(p(HGNC:IL18)) - - - - - pmid:22040696 + pubmed:30962309 - complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) decreases act(p(HGNC:CHRNA7)) + act(complex(MESH:Inflammasomes)) association path(DOID:cancer) - pmid:19293145 + pubmed:30962309 - complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases path(HBP:neurotoxicity) + act(complex(MESH:Inflammasomes)) association path(DOID:"multiple sclerosis") - pmid:19293145 + pubmed:30962309 - complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) decreases complex(a(MESH:Bungarotoxins), p(HGNC:CHRNA7)) + act(complex(MESH:Inflammasomes)) association path(DOID:"rheumatic disease") - pmid:18986241 + pubmed:30962309 - complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases r(HGNC:CHRNA7) + complex(MESH:Inflammasomes) regulates path(MESH:Microbiota) - pmid:18986241 + pubmed:30962309 - complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) decreases bp(GO:"GO:0007271") + complex(MESH:Inflammasomes) decreases path(MESH:"Host-Pathogen Interactions") - pmid:22040696 + pubmed:30962309 - complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases bp(GO:"neuron death") + complex(MESH:Inflammasomes) decreases path(DOID:"inflammatory bowel disease") - - - - - pmid:19293145 + pubmed:30988501 - composite(p(HGNC:MAPK1), p(HGNC:MAPK3)) association bp(GO:memory) + act(complex(MESH:Inflammasomes)) increases a(MESH:"Inflammation Mediators") - - - - - pmid:19293145 + pubmed:30962309 - composite(p(FPLX:ERK), p(HGNC:CHRNA7)) increases p(HGNC:MAPT, pmod(Ph)) + path(NCIT:C50773) increases complex(MESH:Inflammasomes) - + + + pubmed:30962309 + + path(MESH:Metabolome) increases complex(MESH:Inflammasomes) + - pmid:19293145 + pubmed:30962309 - composite(p(FPLX:JNK), p(HGNC:CHRNA7)) increases p(HGNC:MAPT, pmod(Ph)) + g(HGNC:NLRP3) increases complex(MESH:Inflammasomes) - - - pmid:19293145 + pubmed:24561250 - complex(p(FPLX:AKT), p(HGNC:BAD)) regulates bp(GO:"apoptotic process") + g(HGNC:NLRP3) increases a(CHEBI:amyloid-beta) - pmid:19293145 + pubmed:24561250 - bp(GO:"insulin receptor signaling pathway") association p(FPLX:AKT) + g(HGNC:NLRP3) decreases bp(GO:memory) - pmid:24653673 + pubmed:24561250 - bp(GO:"insulin receptor signaling pathway") increases p(HGNC:PPP2CA, pmod(Ph, Tyr, 307)) + g(HGNC:NLRP3) decreases bp(GO:behavior) - pmid:24653673 + pubmed:30962309 - bp(GO:"insulin receptor signaling pathway") increases p(HGNC:PPP2CB, pmod(Ph, Tyr, 307)) + g(HGNC:MEFV) increases complex(MESH:Inflammasomes) - pmid:29191965 + pubmed:30962309 - bp(GO:"insulin receptor signaling pathway") association a(CHEBI:ethosuximide) + p(HGNC:NLRP3, var("?")) increases path(NCIT:C84657) - pmid:19293145 + pubmed:30962309 - bp(GO:"choline transport") association a(CHEBI:"amyloid-beta") + p(HGNC:NLRP3, var("?")) increases path(DOID:"familial Mediterranean fever") - - - pmid:19293145 + pubmed:30962309 - complex(a(MESH:Bungarotoxins), p(HGNC:CHRNA7)) decreases complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) + p(HGNC:NLRP3) increases act(p(HGNC:IL1B)) - pmid:19293145 + pubmed:30962309 - complex(a(MESH:Bungarotoxins), p(HGNC:CHRNA7)) decreases complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) + p(HGNC:NLRP3) increases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:19293145 + pubmed:30962309 - complex(a(MESH:Bungarotoxins), p(HGNC:CHRNA7)) decreases complex(a(CHEBI:methyllycaconitine), p(HGNC:CHRNA7)) + p(HGNC:NLRP3) increases act(p(HGNC:IL18)) - - - - - pmid:25514383 + pubmed:30962309 - a(CHEBI:methyllycaconitine) decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + p(HGNC:NLRP3) increases tloc(p(HGNC:IL18), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + - pmid:25514383 + pubmed:30962309 - a(CHEBI:methyllycaconitine) decreases bp(HP:Neurodegeneration) + p(HGNC:NLRP3) association m(MIRBASE:hsa-mir-223) - - - - - pmid:19293145 + pubmed:30962309 - p(HGNC:APP, frag("25_35")) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + p(HGNC:NLRP3) positiveCorrelation bp(GO:"monocyte differentiation") - pmid:19293145 + pubmed:30962309 - p(HGNC:APP, frag("25_35")) increases act(p(HGNC:CHRNA7)) + p(HGNC:NLRP3) directlyIncreases bp(GO:"evasion or tolerance of host defenses by virus") @@ -70908,2467 +71595,2381 @@

Statements

- pmid:19721446 + pubmed:27314526 - complex(p(HGNC:CHRNA4), p(HGNC:CHRNA5), p(HGNC:CHRNB2)) association a(MESH:"Dopaminergic Neurons") + p(HGNC:NLRP3) association a(CHEBI:amyloid-beta) - pmid:21482353 + pubmed:27314526 - p(HGNC:CHRNA7, var("?")) positiveCorrelation path(MESH:Schizophrenia) + act(p(HGNC:NLRP3)) increases tloc(p(HGNC:CASP1), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - - - - - pmid:19293145 + pubmed:30962309 - composite(a(CHEBI:"amyloid-beta"), p(MGI:Ache)) increases r(MGI:Chrna7) + path(NCIT:C84657) directlyIncreases bp(GO:"activation of innate immune response") - pmid:19293145 + pubmed:30962309 - composite(a(CHEBI:"amyloid-beta"), p(MGI:Ache)) causesNoChange r(MGI:Chrna4) + path(NCIT:C84657) isA path(NCIT:C119050) - pmid:23038257 + pubmed:30962309 - a(CHEBI:"4-(trimethylammonium)benzenediazonium") decreases act(a(MESH:"Electric Organ")) + p(HGNC:MEFV, var("?")) increases path(NCIT:C84657) - pmid:23038257 + pubmed:30962309 - a(MESH:Curare) decreases act(a(CHEBI:"4-(trimethylammonium)benzenediazonium")) + p(HGNC:MEFV, var("?")) increases path(DOID:"familial Mediterranean fever") + + - pmid:23038257 + pubmed:30962309 - a(CHEBI:"4-(N-Maleimido)phenyltrimethylammonium iodide") increases act(a(MESH:"Affinity Labels")) + p(HGNC:MEFV) increases act(p(HGNC:IL1B)) - pmid:23038257 + pubmed:30962309 - a(CHEBI:decamethonium) decreases act(a(MESH:"Receptors, Nicotinic")) + p(HGNC:MEFV) increases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:26813123 + pubmed:30962309 - a(MESH:"Receptors, Nicotinic") increases act(a(MESH:"Hypothalamo-Hypophyseal System")) + p(HGNC:MEFV) increases act(p(HGNC:IL18)) - pmid:26813123 + pubmed:30962309 - act(a(MESH:"Receptors, Nicotinic")) increases bp(MESH:"Synaptic Transmission") + p(HGNC:MEFV) increases tloc(p(HGNC:IL18), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:26813123 + pubmed:30962309 - a(MESH:"Receptors, Nicotinic") regulates tloc(a(CHEBI:neurotransmitter), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) + path(DOID:"familial Mediterranean fever") directlyIncreases bp(GO:"activation of innate immune response") - pmid:26813123 + pubmed:30962309 - act(a(MESH:"Receptors, Nicotinic")) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(GO:"extracellular region"), toLoc(GO:synapse)) + path(DOID:"familial Mediterranean fever") isA path(NCIT:C119050) - pmid:26813123 + pubmed:27794524 - act(a(MESH:"Receptors, Nicotinic")) increases p(HGNC:MAPT, pmod(Ph)) + bp(GO:"activation of innate immune response") directlyIncreases tloc(a(CHEBI:"reactive oxygen species"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:19721446 + pubmed:27794524 - a(MESH:"Receptors, Nicotinic") regulates sec(a(CHEBI:serotonin)) + bp(GO:"activation of innate immune response") directlyIncreases tloc(a(CHEBI:"reactive nitrogen species"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:23038257 + pubmed:27794524 - a(MESH:"Gallamine Triethiodide") decreases act(a(MESH:"Receptors, Nicotinic")) + bp(GO:"activation of innate immune response") directlyIncreases tloc(a(CHEBI:"nitric oxide"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - pmid:28901280 + pubmed:30962309 - p(MESH:"Receptors, Nicotinic") isA p(MESH:"Cysteine Loop Ligand-Gated Ion Channel Receptors") + path(DOID:cancer) association act(complex(MESH:Inflammasomes)) - pmid:28901280 + pubmed:30962309 - p(MESH:"Receptors, Nicotinic") association path(MESH:Learning) + path(DOID:cancer) association p(HGNC:IL1B) - pmid:28901280 + pubmed:30962309 - p(MESH:"Receptors, Nicotinic") association path(MESH:Memory) + path(DOID:cancer) association p(HGNC:IL18) - pmid:28901280 + pubmed:25546293 - p(MESH:"Receptors, Nicotinic") association path(MESH:Arousal) + path(DOID:cancer) increases p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)) - pmid:28901280 + pubmed:30962309 - p(MESH:"Receptors, Nicotinic") association path(MESH:Reward) + path(DOID:"multiple sclerosis") association act(complex(MESH:Inflammasomes)) - pmid:28901280 + pubmed:30962309 - p(MESH:"Receptors, Nicotinic") association bp(MESH:Analgesia) + path(DOID:"multiple sclerosis") association p(HGNC:IL1B) - pmid:28901280 + pubmed:30962309 - p(MESH:"Receptors, Nicotinic") association bp(GO:"action potential initiation") + path(DOID:"multiple sclerosis") association p(HGNC:IL18) - pmid:28901280 + pubmed:30962309 - p(MESH:"Receptors, Nicotinic") association bp(HBP:"cell population proliferation") + path(DOID:"multiple sclerosis") association path(MESH:Autoimmunity) - pmid:28901280 + pubmed:30962309 - p(MESH:"Receptors, Nicotinic") association bp(GO:"cell differentiation") + path(DOID:"multiple sclerosis") negativeCorrelation m(MIRBASE:hsa-mir-146a) - pmid:28901280 + pubmed:30962309 - p(MESH:"Receptors, Nicotinic") association path(MESH:"Cognition Disorders") + path(DOID:"multiple sclerosis") negativeCorrelation m(MIRBASE:hsa-mir-155) - pmid:28901280 + pubmed:30962309 - p(MESH:"Receptors, Nicotinic") association path(MESH:Anxiety) + path(DOID:"multiple sclerosis") directlyIncreases m(MIRBASE:hsa-mir-155) - pmid:28901280 + pubmed:30962309 - p(MESH:"Receptors, Nicotinic") association path(MESH:Depression) + path(DOID:"multiple sclerosis") negativeCorrelation m(MIRBASE:hsa-mir-223) - pmid:28901280 + pubmed:30962309 - p(MESH:"Receptors, Nicotinic") association path(MESH:"Alzheimer Disease") + path(DOID:"multiple sclerosis") directlyIncreases m(MIRBASE:hsa-mir-22, loc(MESH:Plasma)) - pmid:28901280 + pubmed:27889190 - p(MESH:"Receptors, Nicotinic") association path(MESH:"Parkinson Disease") + path(DOID:"multiple sclerosis") association bp(MESH:Sensation) - pmid:28901280 + pubmed:27889190 - p(MESH:"Receptors, Nicotinic") association path(MESH:Pain) + path(DOID:"multiple sclerosis") association path(MESH:"Mobility Limitation") - pmid:28901280 + pubmed:27889190 - p(MESH:"Receptors, Nicotinic") association path(MESH:Epilepsy) + path(DOID:"multiple sclerosis") association bp(MESH:"Postural Balance") - pmid:28901280 + pubmed:27889190 - p(MESH:"Receptors, Nicotinic") association a(MESH:Neurons) + path(DOID:"multiple sclerosis") association a(NCIT:C28381) - pmid:28901280 + pubmed:27889190 - p(MESH:"Receptors, Nicotinic", loc(MESH:"GABAergic Neurons")) association a(HBP:neurotransmitters) + path(DOID:"multiple sclerosis") association bp(MESH:"Vision, Ocular") - pmid:28901280 + pubmed:27889190 - p(MESH:"Receptors, Nicotinic", loc(MESH:"Cholinergic Neurons")) association a(HBP:neurotransmitters) + path(DOID:"multiple sclerosis") association bp(GO:cognition) - pmid:23038257 + pubmed:30988501 - p(HGNC:SCNN1D) association a(CHEBI:chlorpromazine) + path(DOID:"multiple sclerosis") decreases bp(GO:cognition) - - - pmid:23038257 + pubmed:30988501 - a(CHEBI:"zinc(2+)") increases act(p(MESH:"Receptors, Nicotinic")) + path(DOID:"multiple sclerosis") decreases bp(GO:cognition) - pmid:19721446 + pubmed:27889190 - a(CHEBI:"zinc(2+)") decreases act(p(HBP:"alpha-4 beta-2 nAChR")) + path(DOID:"multiple sclerosis") increases bp(MESH:"Lymphocyte Count") - pmid:2833519 + pubmed:27889190 - a(CHEBI:"zinc(2+)") increases act(p(HGNC:S100B)) + path(DOID:"multiple sclerosis") increases p(MESH:Proteins) - pmid:23038257 + pubmed:27889190 - a(MESH:Galantamine) regulates act(p(MESH:"Receptors, Nicotinic")) + path(DOID:"multiple sclerosis") increases p(MESH:"Immunoglobulin G") - pmid:23038257 + pubmed:27889190 - a(MESH:Ivermectin) increases act(p(HGNC:CHRNA7)) + path(DOID:"multiple sclerosis") positiveCorrelation path(MESH:"Spinal Cord Injuries") - pmid:23038257 + pubmed:27889190 - p(HGNC:SCNN1D, var("?")) regulates act(a(MESH:Ivermectin)) + path(DOID:"multiple sclerosis") increases path(HP:"CNS demyelination") - pmid:23038257 + pubmed:26445701 - a(MESH:Anesthetics) decreases p(MESH:"Receptors, Nicotinic") + path(DOID:"multiple sclerosis") increases path(HP:"CNS demyelination") - pmid:23038257 + pubmed:27889190 - a(MESH:Anesthetics) increases p(MESH:"Receptors, GABA") + path(DOID:"multiple sclerosis") increases path(HP:"CNS demyelination") - pmid:19721446 + pubmed:30988501 - a(MESH:Anesthetics) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + path(DOID:"multiple sclerosis") increases path(HP:"CNS demyelination") - pmid:23038257 + pubmed:27889190 - p(MESH:Agrin) increases p(HGNC:RAPSN, pmod(Ph, Tyr)) + path(DOID:"multiple sclerosis") increases path(HP:Encephalopathy) - pmid:23038257 + pubmed:27889190 - p(HGNC:RAPSN, pmod(Ph, Tyr)) increases act(a(MESH:"Motor Endplate"), ma(GO:localization)) + path(DOID:"multiple sclerosis") increases path(MESH:"Neurologic Manifestations") - - - pmid:22040696 + pubmed:27889190 - p(HGNC:RAPSN) increases bp(GO:"skeletal muscle acetylcholine-gated channel clustering") + path(DOID:"multiple sclerosis") increases path(HP:Seizures) - pmid:23038257 + pubmed:27889190 - p(MESH:"Receptors, Nicotinic", pmod(Ph)) increases act(p(MESH:Agrin)) + path(DOID:"multiple sclerosis") association path(MESH:"Central Nervous System Diseases") - pmid:23038257 + pubmed:27889190 - p(MESH:"Cytoskeletal Proteins") association p(HGNC:CHRNA4) + path(DOID:"multiple sclerosis") association path(DOID:"leukoencephalopathy with vanishing white matter") - pmid:24511233 + pubmed:27889190 - p(HGNC:CHRM1) association bp(GO:cognition) + path(DOID:"multiple sclerosis") association path(MESH:"Vasculopathy, Retinal, With Cerebral Leukodystrophy") - pmid:24511233 + pubmed:27889190 - act(p(HGNC:CHRM1)) increases bp(GO:cognition) + path(DOID:"multiple sclerosis") association path(MESH:"Brain Diseases, Metabolic") - pmid:24590577 + pubmed:27889190 - act(p(HGNC:CHRM1)) increases bp(GO:cognition) + path(DOID:"multiple sclerosis") association path(DOID:neurosarcoidosis) - pmid:24511233 + pubmed:27889190 - p(HGNC:CHRM1) decreases act(a(CHEBI:amphetamine)) + path(DOID:"multiple sclerosis") association path(DOID:"central nervous system vasculitis") - pmid:24511233 + pubmed:27889190 - p(HGNC:CHRM1) decreases bp(GO:"dopamine secretion, neurotransmission") + path(DOID:"multiple sclerosis") association path(DOID:"Behcet's disease") - pmid:24511233 + pubmed:28843454 - p(HGNC:CHRM1) increases act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) + path(DOID:"multiple sclerosis") association path(MESH:"Life Style") - pmid:24511233 + pubmed:28843454 - act(p(HGNC:CHRM1)) increases act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) + path(DOID:"multiple sclerosis") association path(MESH:Environment) - pmid:24511233 + pubmed:28843454 - p(HGNC:CHRM1) increases bp(GO:"long-term synaptic potentiation") + path(DOID:"multiple sclerosis") positiveCorrelation path(NCIT:C68642) - pmid:24511233 + pubmed:28843454 - act(p(HGNC:CHRM1)) increases a(CHEBI:acetylcholine) + path(DOID:"multiple sclerosis") association path(MESH:Sunlight) - pmid:24511233 + pubmed:28843454 - act(p(HGNC:CHRM1)) increases deg(a(HBP:"sAPP-alpha")) + path(DOID:"multiple sclerosis") association bp(GO:"response to light intensity") - pmid:24590577 + pubmed:28843454 - act(p(HGNC:CHRM1)) increases a(HBP:"sAPP-alpha") + path(DOID:"multiple sclerosis") association a(CHEBI:"24,25-Dihydroxyvitamin D") - pmid:26813123 + pubmed:28843454 - act(p(HGNC:CHRM1)) association a(MESH:"Cholinergic Neurons") + path(DOID:"multiple sclerosis") negativeCorrelation a(MESH:"Vitamin D") - pmid:26813123 + pubmed:28843454 - act(p(HGNC:CHRM1)) association path(MESH:"Cognitive Dysfunction") + path(DOID:"multiple sclerosis") increases path(MESH:"Epstein-Barr Virus Infections") - pmid:26813123 + pubmed:26445701 - act(p(HGNC:CHRM1)) association act(p(HGNC:MAPT)) + path(DOID:"multiple sclerosis") positiveCorrelation path(MESH:"Epstein-Barr Virus Infections") - pmid:26813123 + pubmed:28843454 - act(p(HGNC:CHRM1)) association act(a(CHEBI:"amyloid-beta")) + path(DOID:"multiple sclerosis") association path(EFO:"human herpesvirus 6 seropositivity") - pmid:24590577 + pubmed:28843454 - act(p(HGNC:CHRM1)) decreases a(CHEBI:"amyloid-beta") + path(DOID:"multiple sclerosis") increases p(MESH:Antibodies) - pmid:26813123 + pubmed:28843454 - act(p(HGNC:CHRM1)) decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + path(DOID:"multiple sclerosis") positiveCorrelation g(IMGTHLA:HLA00865) - pmid:26813123 + pubmed:28843454 - act(p(HGNC:CHRM1)) increases act(p(FPLX:PKC)) + path(DOID:"multiple sclerosis") association a(MESH:"DNA, Mitochondrial") - pmid:24590577 + pubmed:28843454 - act(p(HGNC:CHRM1)) increases act(p(FPLX:PKC)) + path(DOID:"multiple sclerosis") association p(HGNC:HLA-DRB1) - pmid:24590577 + pubmed:28843454 - act(p(HGNC:CHRM1)) increases act(p(FPLX:PKC)) + path(DOID:"multiple sclerosis") association path(EFO:"developmental disability") - pmid:24590577 + pubmed:28843454 - act(p(HGNC:CHRM1)) increases act(p(FPLX:PKC)) + path(DOID:"multiple sclerosis") association path(DOID:"mental depression") - pmid:26813123 + pubmed:28843454 - act(p(HGNC:CHRM1)) decreases act(p(HGNC:GSK3B)) + path(DOID:"multiple sclerosis") association path(MESH:Fatigue) - pmid:24590577 + pubmed:28843454 - act(p(HGNC:CHRM1)) decreases act(p(HGNC:GSK3B)) + path(DOID:"multiple sclerosis") decreases path(MESH:Exercise) - pmid:24590577 + pubmed:28843454 - p(HGNC:CHRM1) association a(MESH:Hippocampus) + path(DOID:"multiple sclerosis") association path(DOID:"cognitive disorder") - pmid:24590577 + pubmed:30988501 - p(HGNC:CHRM1) association a(MESH:"Cerebral Cortex") + path(DOID:"multiple sclerosis") increases path(NCIT:C21007) - pmid:24590577 + pubmed:30988501 - p(HGNC:CHRM1) association a(MESH:"Corpus Striatum") + path(DOID:"multiple sclerosis") decreases path(MESH:"Life Expectancy") - pmid:24590577 + pubmed:30988501 - p(HGNC:CHRM1) association a(MESH:Thalamus) + path(DOID:"multiple sclerosis") increases path(HP:"Axonal loss") - pmid:24590577 + pubmed:26445701 - p(HGNC:CHRM1) association bp(GO:"regulation of synaptic plasticity") + path(DOID:"multiple sclerosis") increases path(HP:"Axonal loss") - pmid:24590577 + pubmed:26445701 - p(HGNC:CHRM1) association bp(GO:learning) + path(DOID:"multiple sclerosis") increases path(HP:"Axonal loss") - pmid:24590577 + pubmed:26445701 - p(HGNC:CHRM1) association bp(GO:memory) + path(DOID:"multiple sclerosis") isA path(DOID:"autoimmune disease of central nervous system") - pmid:24590577 + pubmed:26445701 - p(HGNC:CHRM1) association bp(GO:"neuronal signal transduction") + path(DOID:"multiple sclerosis") increases path(MESH:Inflammation) - pmid:24590577 + pubmed:26445701 - p(HGNC:CHRM1) association bp(GO:"neuron differentiation") + path(DOID:"multiple sclerosis") increases path(MESH:Inflammation) - pmid:24590577 + pubmed:26445701 - p(HGNC:CHRM1) regulates bp(GO:"synaptic transmission, glutamatergic") + path(DOID:"multiple sclerosis") positiveCorrelation g(HGNCGENEFAMILY:"Histocompatibility complex") - pmid:24590577 + pubmed:26445701 - act(p(HGNC:CHRM1)) increases bp(GO:"ERK1 and ERK2 cascade") + path(DOID:"multiple sclerosis") positiveCorrelation g(HGNC:IL2RA) - pmid:24590577 + pubmed:26445701 - act(p(HGNC:CHRM1)) causesNoChange bp(GO:"ERK1 and ERK2 cascade") + path(DOID:"multiple sclerosis") positiveCorrelation g(HGNC:IL7R) - pmid:24590577 + pubmed:26445701 - act(p(HGNC:CHRM1)) increases p(HGNC:BACE1) + path(DOID:"multiple sclerosis") positiveCorrelation path(MESH:"Vitamin D Deficiency") - pmid:24590577 + pubmed:26445701 - p(HGNC:CHRM1) regulates p(HGNC:BACE1) + path(DOID:"multiple sclerosis") increases deg(a(GO:"myelin sheath")) - pmid:24590577 + pubmed:26445701 - act(p(HGNC:CHRM1)) increases bp(GO:"MAPK cascade") + path(DOID:"multiple sclerosis") association a(MESH:B-Lymphocytes) - pmid:24590577 + pubmed:26445701 - act(p(HGNC:CHRM1)) increases bp(HBP:neurotoxicity) + path(DOID:"multiple sclerosis") increases path(MESH:"Diffuse Axonal Injury") - pmid:24590577 + pubmed:26445701 - act(p(HGNC:CHRM1)) increases bp(GO:"Wnt signaling pathway") + path(DOID:"multiple sclerosis") increases a(HP:"Focal white matter lesions") - pmid:24590577 + pubmed:26445701 - act(p(HGNC:CHRM1)) decreases p(HGNC:MAPT, pmod(Ph)) + path(DOID:"multiple sclerosis") association bp(GO:"sensory perception") - pmid:24590577 + pubmed:26445701 - act(p(HGNC:CHRM1)) decreases path(MESH:"DNA Damage") + path(DOID:"multiple sclerosis") association bp(GO:"motor behavior") - pmid:24590577 + pubmed:26445701 - act(p(HGNC:CHRM1)) decreases path(MESH:"Oxidative Stress") + path(DOID:"multiple sclerosis") association bp(GO:"visual behavior") - pmid:24590577 + pubmed:26445701 - act(p(HGNC:CHRM1)) decreases act(p(HGNCGENEFAMILY:Caspases)) + path(DOID:"multiple sclerosis") increases path(HP:Fatigue) - pmid:24590577 + pubmed:26445701 - act(p(HGNC:CHRM1)) decreases bp(GO:"cell death") + path(DOID:"multiple sclerosis") increases path(HP:Spasticity) - pmid:18986241 + pubmed:26445701 - p(HGNC:CHRM1) association path(MESH:D060825) + path(DOID:"multiple sclerosis") increases path(HP:"Gallbladder dysfunction") - pmid:18986241 + pubmed:26445701 - p(HGNC:CHRM1) association path(MESH:D024801) + path(DOID:"multiple sclerosis") increases path(DOID:"pain disorder") - pmid:18986241 + pubmed:27889190 - p(HGNC:CHRM1) association path(MESH:D000686) + path(DOID:"multiple sclerosis") increases bp(GO:"B cell activation") - pmid:26813123 + pubmed:27889190 - p(HGNC:CHRM2) decreases tloc(a(CHEBI:acetylcholine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) + path(DOID:"multiple sclerosis") increases bp(GO:"T cell activation") - pmid:26813123 + pubmed:27889190 - act(p(HGNC:CHRM2)) increases a(CHEBI:"amyloid-beta") + path(DOID:"multiple sclerosis") increases deg(a(MESH:"Blood-Brain Barrier")) - pmid:24590577 + pubmed:27889190 - p(HGNC:CHRM2) association a(MESH:Hippocampus) + path(DOID:"multiple sclerosis") association bp(MESH:"Axonal Transport") - pmid:24590577 + pubmed:30967783 - p(HGNC:CHRM2) association a(MESH:Neocortex) + path(DOID:"multiple sclerosis") association path(CONSO:"mitochondrial dysfunction") - pmid:24590577 + pubmed:30967783 - p(HGNC:CHRM2) decreases act(a(CHEBI:dopamine)) + path(DOID:"multiple sclerosis") increases a(MESH:Macrophages) - pmid:24590577 + pubmed:30967783 - p(HGNC:CHRM3) association a(MESH:Hypothalamus) + path(DOID:"multiple sclerosis") association a(MESH:"Leukocytes, Mononuclear") - pmid:24590577 + pubmed:30967783 - p(HGNC:CHRM3) association a(MESH:Hippocampus) + path(DOID:"multiple sclerosis") increases p(HGNC:CXCL9) - pmid:24511233 + pubmed:30967783 - p(HGNC:CHRM4) association path(MESH:"Avoidance Learning") + path(DOID:"multiple sclerosis") increases p(HGNC:CXCL10) - pmid:24511233 + pubmed:30967783 - p(HGNC:CHRM4) association a(MESH:Hippocampus) + path(DOID:"multiple sclerosis") increases r(HGNC:GAS5, loc(MESH:Microglia)) - pmid:24511233 + pubmed:26979166 - p(HGNC:CHRM4) association a(MESH:"Corpus Striatum") + path(DOID:"multiple sclerosis") increases path(MESH:Depression) - pmid:24590577 + pubmed:26979166 - p(HGNC:CHRM4) association a(MESH:"Corpus Striatum") + path(DOID:"multiple sclerosis") increases bp(GO:"lymphocyte activation") - pmid:24511233 + pubmed:26979166 - p(HGNC:CHRM4) association a(MESH:Neocortex) + path(DOID:"multiple sclerosis") increases bp(GO:"macrophage activation") - pmid:24511233 + pubmed:26979166 - p(HGNC:CHRM4) regulates bp(GO:"synaptic transmission, dopaminergic") + path(DOID:"multiple sclerosis") increases act(a(MESH:"Dendritic Cells")) - pmid:24511233 + pubmed:26979166 - act(p(HGNC:CHRM4)) decreases bp(GO:"synaptic transmission, glutamatergic") + path(DOID:"multiple sclerosis") increases bp(GO:"microglial cell activation") - pmid:24511233 + pubmed:30988501 - p(HGNC:CHRM4) regulates bp(GO:cognition) + path(DOID:"multiple sclerosis") isA path(DOID:encephalomyelitis) - pmid:24590577 + pubmed:30988501 - p(HGNC:CHRM4) association path(MESH:"Psychotic Disorders") + path(DOID:"multiple sclerosis") isA path(MESH:"Autoimmune Diseases") - pmid:24590577 + pubmed:30988501 - p(HGNC:CHRM4) association path(MESH:"Parkinson Disease") + path(DOID:"multiple sclerosis") increases path(CONSO:Neurodegeneration) - pmid:24590577 + pubmed:30988501 - p(HGNC:CHRM4) decreases act(p(HGNC:DRD1)) + path(DOID:"multiple sclerosis") decreases bp(GO:"learning or memory") - pmid:24590577 + pubmed:30988501 - p(HGNC:CHRM5) association a(MESH:"Pars Compacta") + path(DOID:"multiple sclerosis") increases path(DOID:"secondary progressive multiple sclerosis") - pmid:24590577 + pubmed:30988501 - p(HGNC:CHRM5) increases bp(GO:"response to drug") + path(DOID:"multiple sclerosis") increases deg(a(MESH:"Cerebral Cortex")) - pmid:24590577 + pubmed:30988501 - p(HGNC:CHRM5) increases act(a(CHEBI:morphine)) + path(DOID:"multiple sclerosis") decreases a(MESH:"T-Lymphocytes, Regulatory") - pmid:24590577 + pubmed:30988501 - p(HGNC:CHRM5) increases act(a(CHEBI:cocaine)) + path(DOID:"multiple sclerosis") decreases a(MESH:"B-Lymphocytes, Regulatory") - - - - - pmid:24511233 + pubmed:30988501 - complex(p(HGNC:CHRM1), p(HGNC:GNAQ)) increases bp(GO:"calcium ion transport") + path(DOID:"multiple sclerosis") increases deg(a(MESH:"Gray Matter")) - pmid:24511233 + pubmed:30988501 - complex(p(HGNC:CHRM1), p(HGNC:GNAQ)) increases a(MESH:"Inositol 1,4,5-Trisphosphate") + path(DOID:"multiple sclerosis") positiveCorrelation path(MESH:"Psychosocial Deprivation") - pmid:26088141 + pubmed:30962309 - p(HGNC:GNAQ) increases complex(p(HGNC:CHRNA7), p(HGNC:GNAQ)) + path(DOID:"rheumatic disease") association act(complex(MESH:Inflammasomes)) - - - - - pmid:24511233 + pubmed:30962309 - complex(p(HGNC:CHRM3), p(HGNC:GNAQ)) increases bp(GO:"calcium ion transport") + path(DOID:"rheumatic disease") association p(HGNC:IL1B) - pmid:24511233 + pubmed:30962309 - complex(p(HGNC:CHRM3), p(HGNC:GNAQ)) increases a(MESH:"Inositol 1,4,5-Trisphosphate") + path(DOID:"rheumatic disease") association p(HGNC:IL18) - - - - - pmid:24511233 + pubmed:30962309 - complex(p(HGNC:CHRM5), p(HGNC:GNAQ)) increases bp(GO:"calcium ion transport") + path(DOID:"rheumatic disease") association path(MESH:Autoimmunity) - pmid:24511233 + pubmed:30962309 - complex(p(HGNC:CHRM5), p(HGNC:GNAQ)) increases a(MESH:"Inositol 1,4,5-Trisphosphate") + path(MESH:Autoimmunity) association path(DOID:"rheumatic disease") - - - - - pmid:24511233 + pubmed:30962309 - complex(p(HGNC:CHRM2), p(HGNC:GNAI1)) decreases a(CHEBI:"3',5'-cyclic AMP") + path(MESH:Autoimmunity) association path(DOID:"multiple sclerosis") - pmid:26088141 + pubmed:27794524 - p(HGNC:GNAI1) increases complex(p(HGNC:CHRNA7), p(HGNC:GNAI1)) + path(MESH:Autoimmunity) association path(MESH:"Multiple Sclerosis") - - - - - pmid:24511233 + pubmed:27794524 - complex(p(HGNC:CHRM4), p(HGNC:GNAI1)) decreases a(CHEBI:"3',5'-cyclic AMP") + path(MESH:Autoimmunity) causesNoChange path(MESH:"Tertiary Lymphoid Structures") - pmid:17009926 + pubmed:30962309 - path(MESH:Depression) association p(FPLX:CHRN) + r(MESH:MicroRNAs) regulates complex(MESH:Inflammasomes) - pmid:11230871 + pubmed:30962309 - path(MESH:Depression) association p(FPLX:CHRN) + p(HGNC:NLRP1) increases act(p(HGNC:IL1B)) - pmid:26813123 + pubmed:30962309 - path(MESH:Depression) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:NLRP1) increases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:21482353 + pubmed:24561250 - path(MESH:Depression) association bp(GO:"synaptic transmission, cholinergic") + p(HGNC:NLRP1) increases p(HGNC:IL1B) - pmid:19721446 + pubmed:30962309 - path(MESH:Depression) increases a(CHEBI:choline) + p(HGNC:NLRP1) increases act(p(HGNC:IL18)) - pmid:28901280 + pubmed:30962309 - path(MESH:Depression) association p(MESH:"Receptors, Nicotinic") + p(HGNC:NLRP1) increases tloc(p(HGNC:IL18), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:29687724 + pubmed:24561250 - path(MESH:Depression) association path(MESH:"Huntington Disease") + p(HGNC:NLRP1) increases p(HGNC:IL18) - - - pmid:27314526 - - bp(HBP:neuroinflammation) association sec(a(MESH:Interleukins)) - + - - - pmid:24511233 - - a(MESH:"Muscarinic Antagonists") decreases bp(GO:cognition) - + - - - pmid:24511233 - - a(MESH:"Muscarinic Antagonists") increases path(MESH:"Cognitive Dysfunction") - + - pmid:24511233 + pubmed:30962309 - a(MESH:"Muscarinic Antagonists") association path(MESH:"Mental Processes") + p(HGNC:NLRC4) increases act(p(HGNC:IL1B)) - pmid:24511233 + pubmed:30962309 - a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") increases bp(GO:"synaptic transmission, cholinergic") + p(HGNC:NLRC4) increases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:26813123 + pubmed:30962309 - a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") increases bp(GO:"synaptic transmission, cholinergic") + p(HGNC:NLRC4) increases act(p(HGNC:IL18)) - pmid:24511233 + pubmed:30962309 - a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") increases bp(GO:cognition) + p(HGNC:NLRC4) increases tloc(p(HGNC:IL18), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - - - pmid:24511233 - - a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") increases path(MESH:"Mental Processes") - + - pmid:24511233 + pubmed:23702978 - a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") association a(MESH:"Cardiovascular System") + act(p(HGNC:NLRC4)) increases complex(p(HGNC:CFL1), p(HGNC:SCAF11)) - - - pmid:24511233 - - a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") association a(MESH:"Gastrointestinal Tract") - + - pmid:17009926 + pubmed:24561250 - a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") decreases path(MESH:"Alzheimer Disease") + p(HGNC:NLRC4) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:17009926 + pubmed:30962309 - a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") decreases act(p(HGNC:ACHE)) + p(HGNC:AIM2) increases act(p(HGNC:IL1B)) - pmid:17009926 + pubmed:30962309 - a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") decreases rxn(reactants(a(CHEBI:acetylcholine)), products(a(CHEBI:acetate), a(CHEBI:choline))) + p(HGNC:AIM2) increases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:17009926 + pubmed:30962309 - a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") increases act(p(FPLX:CHRN)) + p(HGNC:AIM2) increases act(p(HGNC:IL18)) - pmid:24511233 + pubmed:30962309 - path(MESH:"Mental Processes") association a(MESH:"Muscarinic Antagonists") + p(HGNC:AIM2) increases tloc(p(HGNC:IL18), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - - - pmid:24511233 - - a(MESH:"Cardiovascular System") association a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") - + - pmid:24590577 + pubmed:30962309 - a(MESH:"Cardiovascular System") association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") + p(HGNC:CASP4) increases path(MESH:Pyroptosis) - pmid:24511233 + pubmed:30962309 - a(MESH:"Gastrointestinal Tract") association a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") + p(HGNC:CASP4) increases bp(GO:"NLRP3 inflammasome complex assembly") + + - pmid:24511233 + pubmed:30962309 - a(MESH:"Gastrointestinal Tract") association a(CHEBI:xanomeline) + p(HGNC:CASP5) increases path(MESH:Pyroptosis) - pmid:24590577 + pubmed:30962309 - a(MESH:"Gastrointestinal Tract") association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") + p(HGNC:CASP5) increases bp(GO:"NLRP3 inflammasome complex assembly") - pmid:29626319 + pubmed:30962309 - a(MESH:"Gastrointestinal Tract") decreases a(CHEBI:"amyloid-beta") + p(HGNC:CASP8) increases path(MESH:Pyroptosis) - pmid:29626319 + pubmed:30962309 - a(MESH:"Gastrointestinal Tract") decreases a(CHEBI:"amyloid-beta polypeptide 40") + p(HGNC:CASP8) increases bp(GO:"NLRP3 inflammasome complex assembly") - pmid:29626319 + pubmed:30962309 - a(MESH:"Gastrointestinal Tract") causesNoChange a(CHEBI:"amyloid-beta polypeptide 42") + p(HGNC:CASP8, loc(GO:"inflammasome complex")) association m(MIRBASE:hsa-mir-371a) - pmid:24511233 + pubmed:30962309 - path(MESH:Anhedonia) biomarkerFor path(MESH:Schizophrenia) + p(HGNC:CASP8, loc(GO:"inflammasome complex")) association m(MIRBASE:hsa-mir-373) - pmid:24511233 + pubmed:30962309 - path(MESH:"Social Isolation") biomarkerFor path(MESH:Schizophrenia) + p(HGNC:CASP8, loc(GO:"inflammasome complex")) association m(MIRBASE:hsa-mir-543) - pmid:24511233 + pubmed:30962309 - path(MESH:"Memory, Short-Term") association path(MESH:Schizophrenia) + p(HGNC:CASP8, loc(GO:"inflammasome complex")) increases p(HGNC:TNF) + + - pmid:24511233 + pubmed:23516100 - path(MESH:Attention) association path(MESH:Schizophrenia) + act(p(HGNC:CASP8)) increases complex(p(HGNC:CASP8), p(HGNC:MAPT, frag("1_421"))) - pmid:17009926 + pubmed:23516100 - path(MESH:Attention) association p(FPLX:CHRN) + p(HGNC:CASP8) increases p(HGNC:MAPT, frag("?")) - pmid:26813123 + pubmed:23516100 - path(MESH:Attention) association bp(GO:"synaptic transmission, cholinergic") + p(HGNC:CASP8) increases p(HGNC:MAPT, frag("421_*"), var("?")) - pmid:24590577 + pubmed:23702978 - path(MESH:Attention) association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") + p(HGNC:CASP8) increases act(p(HGNC:IL1B)) - pmid:25514383 + pubmed:23702978 - path(MESH:Attention) association a(HP:"cholinergic neuron") + act(p(HGNC:CASP8)) increases act(p(HGNC:IL1B)) - pmid:24511233 + pubmed:23702978 - path(MESH:"Executive Function") association path(MESH:Schizophrenia) + act(p(HGNC:CASP8)) regulates act(p(HGNC:IL1B)) - - - pmid:24511233 - - a(CHEBI:"antipsychotic agent") regulates p(HGNC:DRD2) - + + + - pmid:24511233 + pubmed:23702978 - a(CHEBI:"antipsychotic agent") causesNoChange bp(GO:cognition) + act(p(HGNC:CASP8)) regulates act(p(HGNC:IL18)) - pmid:24511233 + pubmed:30962309 - bp(GO:"gamma-aminobutyric acid signaling pathway") association path(MESH:Schizophrenia) + a(PUBCHEM:223370366) decreases path(DOID:"multiple sclerosis") - pmid:24511233 + pubmed:30962309 - a(CHEBI:xanomeline) increases bp(GO:cognition) + a(PUBCHEM:223370366) regulates complex(MESH:Inflammasomes) - pmid:26813123 + pubmed:30962309 - a(CHEBI:xanomeline) increases bp(GO:cognition) + a(PUBCHEM:223370366) regulates m(MIRBASE:hsa-mir-20a) - pmid:24590577 + pubmed:30962309 - a(CHEBI:xanomeline) increases bp(GO:cognition) + a(PUBCHEM:223370366) regulates m(MIRBASE:hsa-mir-30a) - pmid:24511233 + pubmed:30962309 - a(CHEBI:xanomeline) decreases path(MESH:Hallucinations) + a(PUBCHEM:223370366) regulates m(MIRBASE:hsa-mir-146a) - pmid:26813123 + pubmed:30962309 - a(CHEBI:xanomeline) decreases path(MESH:Hallucinations) + a(PUBCHEM:223370366) association p(HGNC:IFNAR1) - pmid:24511233 + pubmed:27794524 - a(CHEBI:xanomeline) decreases path(MESH:Delusions) + a(PUBCHEM:223370366) decreases path(MESH:"Developmental Disabilities") - pmid:24511233 + pubmed:27794524 - a(CHEBI:xanomeline) decreases path(MESH:Schizophrenia) + a(PUBCHEM:223370366) directlyDecreases path(MESH:"Multiple Sclerosis, Relapsing-Remitting") - pmid:24511233 + pubmed:27794524 - a(CHEBI:xanomeline) increases bp(GO:learning) + a(PUBCHEM:223370366) increases p(MESH:Serum) - pmid:24511233 + pubmed:27794524 - a(CHEBI:xanomeline) increases path(MESH:"Memory, Short-Term") + a(PUBCHEM:223370366) increases p(HGNC:BDNF) - pmid:24511233 + pubmed:27956442 - a(CHEBI:xanomeline) association a(MESH:"Gastrointestinal Tract") + a(PUBCHEM:223370366) decreases path(MESH:"Demyelinating Diseases") - pmid:26813123 + pubmed:27956442 - a(CHEBI:xanomeline) increases bp(GO:memory) + a(PUBCHEM:223370366) causesNoChange path(MESH:"Multiple Sclerosis, Chronic Progressive") - pmid:24590577 + pubmed:30962309 - a(CHEBI:xanomeline) increases bp(GO:memory) + a(PUBCHEM:3081884) decreases path(DOID:"multiple sclerosis") - pmid:26813123 + pubmed:30962309 - a(CHEBI:xanomeline) decreases path(MESH:"Mood Disorders") + a(PUBCHEM:3081884) regulates complex(MESH:Inflammasomes) - pmid:26813123 + pubmed:30962309 - a(CHEBI:xanomeline) decreases path(MESH:"Psychomotor Agitation") + a(PUBCHEM:3081884) decreases m(MIRBASE:hsa-mir-146a) - pmid:24590577 + pubmed:27794524 - a(CHEBI:xanomeline) decreases path(MESH:"Psychotic Disorders") + a(PUBCHEM:3081884) increases p(MESH:Serum) - pmid:24590577 + pubmed:27794524 - a(CHEBI:xanomeline) increases act(p(HGNC:CHRM1)) + a(PUBCHEM:3081884) increases p(HGNC:BDNF) - pmid:24590577 + pubmed:27956442 - a(CHEBI:xanomeline) increases act(p(HGNC:CHRM4)) + a(PUBCHEM:3081884) decreases path(MESH:"Demyelinating Diseases") - pmid:24511233 + pubmed:30962309 - p(MGI:Chrm1) decreases act(a(CHEBI:"amyloid-beta")) + a(PUBCHEM:53787563) decreases path(DOID:"systemic lupus erythematosus") - pmid:24590577 + pubmed:30962309 - p(MGI:Chrm1) increases bp(GO:cognition) + a(PUBCHEM:53787563) regulates complex(MESH:Inflammasomes) - pmid:24590577 + pubmed:30962309 - p(MGI:Chrm1) increases bp(GO:"long-term synaptic potentiation") + path(DOID:"systemic lupus erythematosus") negativeCorrelation m(MIRBASE:hsa-mir-146a) - pmid:24590577 + pubmed:30962309 - act(p(MGI:Chrm1)) decreases bp(HBP:"APP processing") + path(DOID:"systemic lupus erythematosus") directlyIncreases m(MIRBASE:hsa-mir-146a) - pmid:24590577 + pubmed:30962309 - act(p(MGI:Chrm1)) decreases path(MESH:"Plaque, Amyloid") + path(DOID:"systemic lupus erythematosus") negativeCorrelation m(MIRBASE:hsa-mir-155) - pmid:18986241 + pubmed:30962309 - act(p(MGI:Chrm1)) increases act(p(MGI:Adam17)) + path(DOID:"systemic lupus erythematosus") directlyDecreases m(MIRBASE:hsa-mir-155, loc(MESH:"Peripheral Blood Stem Cells")) - pmid:24511233 + pubmed:30962309 - a(MESH:"4-(3-(4-butylpiperidin-1-yl)propyl)-7-fluoro-4H-benzo(1,4)oxazin-3-one") increases act(p(HGNC:CHRM1)) + path(DOID:"systemic lupus erythematosus") directlyIncreases m(MIRBASE:hsa-mir-155, loc(MESH:Urine)) - pmid:24590577 + pubmed:30962309 - a(MESH:"4-(3-(4-butylpiperidin-1-yl)propyl)-7-fluoro-4H-benzo(1,4)oxazin-3-one") increases bp(GO:cognition) + path(DOID:"systemic lupus erythematosus") negativeCorrelation m(MIRBASE:hsa-mir-223) - pmid:24590577 + pubmed:30962309 - a(MESH:"4-(3-(4-butylpiperidin-1-yl)propyl)-7-fluoro-4H-benzo(1,4)oxazin-3-one") association a(MESH:"Antipsychotic Agents") + path(DOID:"systemic lupus erythematosus") directlyDecreases m(MIRBASE:hsa-mir-223, loc(MESH:B-Lymphocytes)) - pmid:24511233 + pubmed:30962309 - a(MESH:"1-(3-(4-butyl-1-piperidinyl)propyl)-3,4-dihydro-2(1H)-quinolinone") increases act(p(HGNC:CHRM1)) + path(DOID:"systemic lupus erythematosus") association g(DBSNP:rs57095329) - pmid:24590577 + pubmed:30962309 - a(MESH:"1-(3-(4-butyl-1-piperidinyl)propyl)-3,4-dihydro-2(1H)-quinolinone") increases act(p(HGNC:CHRM1)) + path(DOID:"systemic lupus erythematosus") association g(DBSNP:rs2431697) - pmid:24590577 + pubmed:30962309 - a(MESH:"1-(3-(4-butyl-1-piperidinyl)propyl)-3,4-dihydro-2(1H)-quinolinone") increases act(a(MESH:"Pyramidal Cells")) + path(DOID:"systemic lupus erythematosus") directlyDecreases m(MIRBASE:hsa-mir-20a, loc(MESH:Monocytes)) - pmid:24511233 + pubmed:30962309 - a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") increases act(p(HGNC:CHRM1)) + path(DOID:"systemic lupus erythematosus") directlyDecreases m(MIRBASE:hsa-mir-17, loc(MESH:"Peripheral Blood Stem Cells")) - pmid:24590577 + pubmed:27889190 - a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") increases act(p(HGNC:CHRM1)) + path(DOID:"systemic lupus erythematosus") increases path(DOID:"optic neuritis") - pmid:24511233 + pubmed:27889190 - a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") decreases act(a(CHEBI:scopolamine)) + path(DOID:"systemic lupus erythematosus") increases path(DOID:myelitis) - pmid:24511233 + pubmed:27889190 - a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") decreases a(CHEBI:"amyloid-beta") + path(DOID:"systemic lupus erythematosus") increases path(MESH:"Abortion, Habitual") - pmid:24590577 + pubmed:30988501 - a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") decreases a(CHEBI:"amyloid-beta") + path(DOID:"systemic lupus erythematosus") increases complex(a(MESH:Autoantibodies), p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) - pmid:24590577 + pubmed:30962309 - a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") increases bp(GO:"NMDA selective glutamate receptor signaling pathway") + a(PUBCHEM:135305802) decreases path(DOID:"rheumatic disease") - pmid:24511233 + pubmed:30962309 - act(a(CHEBI:scopolamine)) decreases bp(GO:"behavioral fear response") + a(PUBCHEM:135305802) directlyDecreases p(HGNC:TNF) - pmid:24511233 + pubmed:30988501 - a(MESH:VU0357017) increases complex(a(MESH:VU0357017), p(HGNC:CHRM1)) + a(PUBCHEM:135305802) decreases p(HGNC:TNF) - pmid:24511233 + pubmed:30962309 - a(MESH:VU0357017) decreases act(a(CHEBI:scopolamine)) + a(PUBCHEM:135305802) regulates complex(MESH:Inflammasomes) - pmid:24511233 + pubmed:30988501 - a(MESH:VU0357017) increases bp(GO:"behavioral fear response") + a(PUBCHEM:135305802) negativeCorrelation path(DOID:"mental depression") - pmid:24590577 + pubmed:30962309 - a(MESH:VU0357017) increases act(p(HGNC:CHRM1)) + act(complex(GO:"NLRP3 inflammasome complex")) increases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:24590577 + pubmed:30962309 - a(MESH:VU0357017) decreases path(MESH:"Cognitive Dysfunction") + complex(GO:"NLRP3 inflammasome complex") increases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:24590577 + pubmed:28019679 - a(MESH:VU0357017) increases bp(GO:learning) + act(complex(GO:"NLRP3 inflammasome complex")) increases p(HGNC:IL1B) - - - - - pmid:24511233 + pubmed:28019679 - complex(a(MESH:VU0357017), p(HGNC:CHRM1)) increases act(p(HGNC:CHRM1)) + act(complex(GO:"NLRP3 inflammasome complex")) increases p(HGNC:IL1B) - - - - - pmid:24511233 + pubmed:24561250 - complex(a(MESH:"GSK 1034702"), p(HGNC:CHRM1)) increases bp(GO:cognition) + complex(GO:"NLRP3 inflammasome complex") increases p(HGNC:IL1B) - pmid:24511233 + pubmed:24561250 - a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases act(p(HGNC:CHRM1)) + complex(GO:"NLRP3 inflammasome complex") increases p(HGNC:IL1B) - pmid:24511233 + pubmed:30962309 - a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases bp(GO:"excitatory postsynaptic potential") + act(complex(GO:"NLRP3 inflammasome complex")) increases tloc(p(HGNC:IL18), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:24511233 + pubmed:28019679 - a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") decreases act(a(CHEBI:scopolamine)) + act(complex(GO:"NLRP3 inflammasome complex")) increases p(HGNC:IL18) - pmid:24511233 + pubmed:30962309 - a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases bp(GO:"behavioral fear response") + act(complex(GO:"NLRP3 inflammasome complex")) increases path(DOID:"neurodegenerative disease") - pmid:24511233 + pubmed:30962309 - a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases bp(GO:learning) + act(complex(GO:"NLRP3 inflammasome complex")) negativeCorrelation path(MESH:Neuralgia) - pmid:24590577 + pubmed:28019679 - a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases bp(GO:learning) + complex(GO:"NLRP3 inflammasome complex") increases act(p(HGNC:CASP1)) - pmid:24511233 + pubmed:28019679 - a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases bp(GO:memory) + act(complex(GO:"NLRP3 inflammasome complex")) increases p(HGNC:CASP1) - pmid:24590577 + pubmed:27314526 - a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases complex(a(CHEBI:acetylcholine), p(HGNC:CHRM1)) + complex(GO:"NLRP3 inflammasome complex") increases p(HGNC:CASP1) - pmid:24590577 + pubmed:28019679 - a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") regulates bp(HBP:"APP processing") + complex(GO:"NLRP3 inflammasome complex") increases a(CHEBI:"nitric oxide") - pmid:24511233 + pubmed:28019679 - a(MESH:"Prefrontal Cortex") association bp(GO:cognition) + complex(GO:"NLRP3 inflammasome complex") increases tloc(p(HGNC:TNF), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:24511233 + pubmed:28019679 - a(MESH:"Prefrontal Cortex") association bp(GO:learning) + act(complex(GO:"NLRP3 inflammasome complex")) decreases path(MESH:"Spatial Memory") - pmid:24511233 + pubmed:28019679 - a(MESH:"Prefrontal Cortex") association bp(GO:memory) + act(complex(GO:"NLRP3 inflammasome complex")) increases a(CHEBI:amyloid-beta) - pmid:24511233 + pubmed:24561250 - a(MESH:"VU 0405652") increases act(p(HGNC:CHRM1)) + complex(GO:"NLRP3 inflammasome complex") association path(MESH:"Alzheimer Disease") - pmid:24511233 + pubmed:24561250 - a(HBP:VU0456940) increases act(p(HGNC:CHRM1)) + complex(GO:"NLRP3 inflammasome complex") increases path(MESH:"Plaque, Amyloid") - - - pmid:24511233 - - a(MESH:"6-(4-butylthio-1,2,5-thiadiazol-3-yl)-1-azabicyclo(3.2.1)octane") decreases act(a(CHEBI:apomorphine)) - + + + + + + + - pmid:24511233 + pubmed:23702978 - a(MESH:"6-(4-butylthio-1,2,5-thiadiazol-3-yl)-1-azabicyclo(3.2.1)octane") decreases path(MESH:"Avoidance Learning") + p(HGNC:PYCARD) increases complex(p(HGNC:CASP1), p(HGNC:CASP1)) + + + + + + + + + + + + - pmid:24511233 + pubmed:24561250 - act(a(CHEBI:apomorphine)) decreases bp(GO:"prepulse inhibition") + p(HGNC:PYCARD) association composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) - pmid:24511233 + pubmed:24561250 - act(a(CHEBI:apomorphine)) decreases bp(GO:"prepulse inhibition") + p(HGNC:PYCARD) association composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) - pmid:24511233 + pubmed:24561250 - path(MESH:"Avoidance Learning") association p(HGNC:CHRM4) + p(HGNC:PYCARD) increases act(complex(GO:"IPAF inflammasome complex")) - pmid:24511233 + pubmed:24561250 - a(MESH:"Corpus Striatum") association p(HGNC:CHRM4) + p(HGNC:PYCARD) increases act(complex(GO:"IPAF inflammasome complex")) - pmid:24590577 + pubmed:24561250 - a(MESH:"Corpus Striatum") association p(HGNC:CHRM4) + p(HGNC:PYCARD) increases act(complex(GO:"IPAF inflammasome complex")) + + + + - pmid:24590577 + pubmed:24561250 - a(MESH:"Corpus Striatum") association p(HGNC:CHRM1) + p(HGNC:PYCARD) increases p(HGNC:IL18) - pmid:24762290 + pubmed:24561250 - a(MESH:"Corpus Striatum") association complex(HBP:"alpha-4 beta-2 nAChR") + p(HGNC:PYCARD) increases p(HGNC:IL1B) + + - pmid:24511233 + pubmed:24561250 - a(MESH:Neocortex) association p(HGNC:CHRM4) + p(HGNC:PYCARD) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + - pmid:24590577 + pubmed:23516100 - a(MESH:Neocortex) association p(HGNC:CHRM2) + p(HGNC:CASP1) increases p(HGNC:MAPT, frag("?")) - pmid:24511233 + pubmed:21722302 - a(HBP:VU10010) increases act(a(CHEBI:acetylcholine)) + act(p(HGNC:CASP1)) increases bp(MESH:"Cell Death") - pmid:24511233 + pubmed:28019679 - a(HBP:VU10010) increases act(p(HGNC:CHRM4)) + p(HGNC:CASP1) increases act(p(HGNC:IL18)) - pmid:24511233 + pubmed:23702978 - a(MESH:"3-amino-N-(4-methoxybenzyl)-4,6-dimethylthieno(2,3-b)pyridine-2-carboxamide") decreases act(a(CHEBI:amphetamine)) + act(p(HGNC:CASP1)) increases act(p(HGNC:IL18)) - pmid:24511233 + pubmed:23702978 - a(HBP:VU0152099) decreases act(a(CHEBI:amphetamine)) + act(p(HGNC:CASP1)) increases act(p(HGNC:IL18)) - pmid:24511233 + pubmed:23702978 - a(MESH:"3-amino-5-chloro-6-methoxy-4-methyl-thieno(2,3-b)pyridine-2-carboxylic acid cyclopropylamide") decreases act(a(CHEBI:amphetamine)) + act(p(HGNC:CASP1)) increases tloc(p(HGNC:IL18), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:28445721 + pubmed:24561250 - bp(GO:"neurotransmitter secretion") regulates p(FPLX:CHRN) + p(HGNC:CASP1) increases p(HGNC:IL18) - pmid:21787755 + pubmed:24561250 - bp(GO:"neurotransmitter secretion") association a(HBP:"alpha-7-containing nAChR") + p(HGNC:CASP1) increases p(HGNC:IL18) - pmid:17009926 + pubmed:27314526 - bp(GO:"developmental process") association p(FPLX:CHRN) + act(p(HGNC:CASP1)) increases act(p(HGNC:IL18)) - pmid:17009926 + pubmed:27314526 - path(MESH:Epilepsy) association p(FPLX:CHRN) + tloc(p(HGNC:CASP1), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) increases act(p(HGNC:IL18)) - pmid:17009926 + pubmed:27314526 - path(MESH:Epilepsy) association p(FPLX:CHRN) + act(p(HGNC:CASP1)) increases act(p(HGNC:IL18)) - pmid:11230871 + pubmed:27314526 - path(MESH:Epilepsy) association p(FPLX:CHRN) + act(p(HGNC:CASP1)) increases act(p(HGNC:IL18)) - pmid:21482353 + pubmed:28019679 - path(MESH:Epilepsy) positiveCorrelation p(HGNC:CHRNA4, var("?")) + p(HGNC:CASP1) increases act(p(HGNC:IL1B)) - pmid:21482353 + pubmed:23702978 - path(MESH:Epilepsy) positiveCorrelation p(HGNC:CHRNB2, var("?")) + act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) - pmid:21787755 + pubmed:23702978 - path(MESH:Epilepsy) association a(HBP:AβOs) + act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) - pmid:28901280 + pubmed:23702978 - path(MESH:Epilepsy) association p(MESH:"Receptors, Nicotinic") + act(p(HGNC:CASP1)) increases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:17009926 + pubmed:23702978 - path(MESH:"Autistic Disorder") association p(FPLX:CHRN) + act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) - pmid:17009926 + pubmed:24561250 - path(MESH:"Autistic Disorder") negativeCorrelation act(p(FPLX:CHRN)) + p(HGNC:CASP1) increases p(HGNC:IL1B) - pmid:17009926 + pubmed:27314526 - path(MESH:"Autistic Disorder") negativeCorrelation p(FPLX:CHRN) + act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) - pmid:30106381 + pubmed:27314526 - path(MESH:"Autistic Disorder") association p(HGNC:ADNP) + tloc(p(HGNC:CASP1), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) increases act(p(HGNC:IL1B)) - pmid:30106381 + pubmed:27314526 - path(MESH:"Autistic Disorder") association a(PUBCHEM:9832404) + act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) - pmid:26472524 + pubmed:27314526 - tloc(a(MESH:"Cations, Divalent"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) increases bp(GO:"membrane depolarization") + act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) - pmid:17009926 + pubmed:28019679 - p(HGNC:CHRNA7, var("p.Leu254Thr")) decreases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + act(p(HGNC:CASP1)) increases a(CHEBI:"nitric oxide") - pmid:17009926 + pubmed:28019679 - p(HGNC:CHRNA7, var("p.Leu254Thr")) decreases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) + act(p(HGNC:CASP1)) increases tloc(p(HGNC:TNF), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:17009926 + pubmed:28019679 - p(HGNC:CHRNA7, var("p.Leu255Thr")) decreases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + act(p(HGNC:CASP1)) increases bp(GO:pyroptosis) - pmid:17009926 + pubmed:23702978 - p(HGNC:CHRNA7, var("p.Leu255Thr")) decreases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) + act(p(HGNC:CASP1)) increases bp(GO:pyroptosis) @@ -73383,1333 +73984,1396 @@

Statements

- - - pmid:17009926 - - composite(a(CHEBI:acetylcholine), a(CHEBI:ivermectin)) increases act(p(FPLX:CHRN)) - + - pmid:17009926 + pubmed:24561250 - a(CHEBI:ivermectin) regulates act(p(HGNC:CHRNA7)) + p(HGNC:CASP1) association composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) - - - pmid:17009926 + pubmed:27314526 - composite(a(CHEBI:"1,1-dimethyl-4-phenylpiperazinium iodide"), a(CHEBI:ivermectin)) increases act(p(HGNC:CHRNA7)) + act(p(HGNC:CASP1)) increases act(p(HGNC:IL33)) - - - - - pmid:17009926 + pubmed:27314526 - composite(a(CHEBI:"5-hydroxyindole"), a(CHEBI:acetylcholine)) increases act(p(HGNC:CHRNA7)) + act(p(HGNC:CASP1)) increases act(p(HGNC:IL33)) + + - pmid:17009926 + pubmed:30962309 - a(CHEBI:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methyl-3-isoxazolyl)urea") regulates act(p(HGNC:CHRNA7)) + a(MESH:Brain) increases r(HGNC:NLRP3, loc(MESH:Microglia)) - pmid:28132910 + pubmed:29661268 - a(CHEBI:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methyl-3-isoxazolyl)urea") increases complex(a(GO:membrane), a(PUBCHEM:16068384)) + a(MESH:Brain) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:28132910 + pubmed:27758088 - a(CHEBI:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methyl-3-isoxazolyl)urea") increases complex(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"), a(PUBCHEM:16068384)) + a(MESH:Brain) association r(HGNC:CHRNA5) - pmid:17009926 + pubmed:27758088 - a(CHEBI:"nicotinic acetylcholine receptor agonist") increases sec(a(CHEBI:acetylcholine)) + a(MESH:Brain) association r(HGNC:CHRNA3) - pmid:17009926 + pubmed:21482353 - a(CHEBI:"nicotinic acetylcholine receptor agonist") increases sec(a(CHEBI:dopamine)) + act(a(MESH:Brain)) negativeCorrelation act(p(FPLX:CHRN)) - pmid:17009926 + pubmed:22299660 - a(CHEBI:"nicotinic acetylcholine receptor agonist") increases sec(a(CHEBI:noradrenaline)) + a(MESH:Brain) association p(HGNC:PPP2R2A) - pmid:17009926 + pubmed:30962309 - a(CHEBI:"nicotinic acetylcholine receptor agonist") increases sec(a(CHEBI:serotonin)) + m(MIRBASE:hsa-mir-20a) association a(MESH:"Neural Pathways") - pmid:17009926 + pubmed:30962309 - a(CHEBI:"nicotinic acetylcholine receptor agonist") increases sec(a(CHEBI:"glutamate(2-)")) + m(MIRBASE:hsa-mir-20a) association a(MESH:"Immune System") - pmid:17009926 + pubmed:30962309 - a(CHEBI:"nicotinic acetylcholine receptor agonist") increases sec(a(CHEBI:"gamma-aminobutyric acid")) + m(MIRBASE:hsa-mir-20a) decreases p(HGNC:TXNIP) - pmid:17009926 + pubmed:30962309 - a(CHEBI:"nicotinic acetylcholine receptor agonist") increases bp(GO:memory) + m(MIRBASE:hsa-mir-20a) decreases p(HGNC:TXNIP) - pmid:17009926 + pubmed:30962309 - a(CHEBI:"nicotinic acetylcholine receptor agonist") increases bp(GO:memory) + m(MIRBASE:hsa-mir-20a) decreases p(HGNC:NLRP3) - pmid:17009926 + pubmed:30962309 - a(CHEBI:"nicotinic acetylcholine receptor agonist") increases bp(GO:learning) + m(MIRBASE:hsa-mir-20a) regulates complex(MESH:Inflammasomes) - pmid:17009926 + pubmed:30962309 - a(CHEBI:"nicotinic acetylcholine receptor agonist") increases path(MESH:Attention) + a(MESH:"Neural Pathways") association m(MIRBASE:hsa-mir-20a) - pmid:17009926 + pubmed:30962309 - a(CHEBI:"nicotinic acetylcholine receptor agonist") increases bp(GO:cognition) + a(MESH:"Neural Pathways") association m(MIRBASE:hsa-mir-30a) - pmid:19323834 + pubmed:30962309 - a(CHEBI:noradrenaline) increases p(HGNC:SUMO1) + a(MESH:"Neural Pathways") association m(MIRBASE:hsa-mir-146a) - pmid:17009926 + pubmed:30988501 - a(CHEBI:tetrodotoxin) decreases act(complex(GO:"voltage-gated calcium channel complex")) + a(MESH:"Neural Pathways") increases act(a(MESH:Brain)) - pmid:17009926 + pubmed:30988501 - bp(GO:"regulation of action potential firing rate") association p(FPLX:CHRN) + a(MESH:"Neural Pathways") increases p(HGNC:TNF) - pmid:17009926 + pubmed:30962309 - act(complex(GO:"GABA-A receptor complex")) increases bp(GO:"membrane depolarization") + a(MESH:"Immune System") association m(MIRBASE:hsa-mir-20a) - pmid:17009926 + pubmed:30962309 - bp(GO:"regulation of action potential firing pattern") association p(FPLX:CHRN) + a(MESH:"Immune System") association m(MIRBASE:hsa-mir-30a) - pmid:17009926 + pubmed:30962309 - bp(GO:"action potential") increases sec(a(CHEBI:dopamine)) + a(MESH:"Immune System") association m(MIRBASE:hsa-mir-146a) - pmid:17009926 + pubmed:30962309 - bp(GO:"response to pain") association p(FPLX:CHRN) + m(MIRBASE:hsa-mir-30a) association a(MESH:"Neural Pathways") - pmid:17009926 + pubmed:30962309 - a(PUBCHEM:5311278) decreases act(p(HGNC:CHRNA7)) + m(MIRBASE:hsa-mir-30a) association a(MESH:"Immune System") - pmid:17009926 + pubmed:30962309 - a(PUBCHEM:5311278) decreases bp(GO:memory) + p(HGNC:DGCR8) increases r(MESH:MicroRNAs) - pmid:25514383 + pubmed:30962309 - a(PUBCHEM:5311278) decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + p(HGNC:XPO5) increases p(MESH:"RNA-Binding Proteins", loc(GO:cytoplasm)) + + + + - pmid:26813123 + pubmed:30837838 - p(FPLX:CHRM) isA a(MESH:"Receptors, G-Protein-Coupled") + p(MESH:"RNA-Binding Proteins") association path(MESH:"RNA Stability") - pmid:26813123 + pubmed:30837838 - p(FPLX:CHRM) regulates a(MESH:"Ion Channels") + p(MESH:"RNA-Binding Proteins") association bp(GO:"mRNA processing") - pmid:26813123 + pubmed:30837838 - p(FPLX:CHRM) regulates act(a(MESH:"Calcium Channels")) + p(MESH:"RNA-Binding Proteins") association path(MESH:"RNA Transport") - pmid:26813123 + pubmed:30962309 - p(FPLX:CHRM) regulates act(a(MESH:"Potassium Channels")) + composite(p(HGNC:DICER1), p(MESH:"RNA-Binding Proteins")) increases complex(p(MESH:MicroRNAs), p(MESH:MicroRNAs)) + + + + + + + + + + - pmid:26813123 + pubmed:30962309 - act(p(FPLX:CHRM)) decreases act(a(MESH:"Potassium Channels")) + p(MESH:MicroRNAs) directlyDecreases bp(GO:"mRNA polyadenylation") - pmid:26813123 + pubmed:30962309 - p(FPLX:CHRM) regulates act(a(MESH:"Chloride Channels")) + p(MESH:MicroRNAs) directlyDecreases path(MESH:"RNA Stability") - pmid:26813123 + pubmed:30962309 - act(p(FPLX:CHRM)) decreases bp(GO:"synaptic transmission, glutamatergic") + p(MESH:MicroRNAs) directlyIncreases bp(GO:"exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-independent decay") - pmid:25514383 + pubmed:30962309 - p(FPLX:CHRM) regulates bp(GO:cognition) + p(MESH:MicroRNAs) directlyDecreases bp(GO:translation) + + - pmid:17009926 + pubmed:30962309 - p(HGNC:CHRNA4, var("p.Ser248Thr")) increases path(MESH:Epilepsy) + composite(p(HGNC:NCOA6), p(MESH:"RNA-Binding Proteins")) increases complex(p(MESH:MicroRNAs), p(MESH:MicroRNAs)) + + - pmid:17009926 + pubmed:30962309 - g(HGNC:CHRNA4, var("?")) positiveCorrelation path(MESH:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") + composite(p(HGNCGENEFAMILY:"Argonaute/PIWI family"), p(MESH:MicroRNAs), p(MESH:MicroRNAs)) increases composite(p(HGNCGENEFAMILY:"Argonaute/PIWI family"), p(MESH:MicroRNAs)) + + + + - pmid:17009926 + pubmed:30962309 - path(MESH:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") positiveCorrelation g(HGNC:CHRNA4, var("?")) + composite(p(HGNCGENEFAMILY:"Argonaute/PIWI family"), p(MESH:MicroRNAs)) directlyDecreases path(MESH:"RNA Stability") - pmid:17009926 + pubmed:30962309 - path(MESH:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") positiveCorrelation g(HGNC:CHRNB2, var("?")) + composite(p(HGNCGENEFAMILY:"Argonaute/PIWI family"), p(MESH:MicroRNAs)) directlyDecreases bp(GO:translation) - pmid:17009926 + pubmed:30837838 - g(HGNC:CHRNB2, var("?")) positiveCorrelation path(MESH:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") + path(MESH:"RNA Stability") association p(MESH:"RNA-Binding Proteins") - pmid:28445721 + pubmed:30837838 - path(MESH:Arousal) association p(FPLX:CHRN) + path(MESH:"RNA Stability") association p(HGNC:TARDBP) - pmid:28901280 + pubmed:30106381 - path(MESH:Arousal) association p(MESH:"Receptors, Nicotinic") + bp(GO:translation) association p(HGNC:MTOR) - pmid:23702978 + pubmed:27181519 - a(CHEBI:"potassium(1+)") decreases bp(GO:"apoptosome assembly") + bp(GO:translation) negativeCorrelation complex(GO:"cytoplasmic stress granule") - pmid:23702978 + pubmed:30837838 - a(CHEBI:"potassium(1+)") increases act(complex(GO:"NLRP1 inflammasome complex")) + bp(GO:translation) negativeCorrelation p(HGNC:TARDBP, var("p.Ala315Thr")) - pmid:23702978 + pubmed:30837838 - a(CHEBI:"potassium(1+)") increases act(complex(GO:"NLRP3 inflammasome complex")) + bp(GO:translation) negativeCorrelation p(HGNC:TARDBP, var("p.Gln343Arg")) - pmid:23702978 + pubmed:30837838 - a(CHEBI:"potassium(1+)") increases act(p(HGNC:PYCARD)) + bp(GO:translation) negativeCorrelation p(HGNC:TARDBP, var("p.Asn352Ser")) - pmid:23702978 + pubmed:30837838 - a(CHEBI:"potassium(1+)") decreases sec(p(HGNC:IL1B)) + bp(GO:translation) negativeCorrelation p(HGNC:TARDBP, var("p.Met337Val")) - pmid:24561250 + pubmed:30837838 - a(CHEBI:"potassium(1+)") increases act(complex(GO:"inflammasome complex")) + bp(GO:translation) negativeCorrelation p(HGNC:TARDBP, var("p.Gly298Ser")) - pmid:26472524 + pubmed:30837838 - act(p(MESH:"Receptors, N-Methyl-D-Aspartate")) increases bp(GO:"long-term synaptic potentiation") + bp(GO:translation) negativeCorrelation p(HGNC:TARDBP, var("p.Gly348Cys")) - pmid:26751493 + pubmed:30837838 - p(MESH:"Receptors, N-Methyl-D-Aspartate") association p(HBP:"projection domain") + bp(GO:translation) negativeCorrelation p(HGNC:TARDBP, var("p.Ala382Thr")) - - - - - - - - - pmid:16820021 + pubmed:30837838 - a(HBP:"SK and F 77434") decreases a(MESH:"8-iodo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7-ol") + bp(GO:translation) negativeCorrelation p(HGNC:TARDBP, var("p.Asp169Gly")) - pmid:16820021 + pubmed:30837838 - a(MESH:antalarmin) causesNoChange act(p(RGD:Drd1)) + bp(GO:translation) negativeCorrelation p(HGNC:TARDBP, var("p.Arg263Glu")) - pmid:16820021 + pubmed:30962309 - a(MESH:antalarmin) increases p(RGD:Drd2) + bp(GO:"mRNA polyadenylation") increases path(MESH:"RNA Stability") - pmid:16820021 + pubmed:30962309 - a(MESH:antalarmin) decreases p(RGD:Drd2) + m(MIRBASE:hsa-mir-223) association p(HGNC:NLRP3) - pmid:16820021 + pubmed:30962309 - a(MESH:antalarmin) increases p(RGD:Drd3) + m(MIRBASE:hsa-mir-223) negativeCorrelation bp(GO:"monocyte differentiation") - pmid:16820021 + pubmed:30962309 - a(MESH:antalarmin) decreases p(RGD:Drd3) + m(MIRBASE:hsa-mir-223) negativeCorrelation r(HGNC:NLRP3) + + - pmid:16820021 + pubmed:30962309 - a(MESH:antalarmin) decreases path(HBP:"isolation rearing") + m(MIRBASE:hsa-mir-223) regulates complex(MESH:Inflammasomes) - pmid:16820021 + pubmed:30962309 - a(MESH:antalarmin) causesNoChange path(HBP:"isolation rearing") + m(MIRBASE:hsa-mir-223) regulates complex(MESH:Inflammasomes) - pmid:16820021 + pubmed:30962309 - a(MESH:antalarmin) causesNoChange path(HBP:"isolation rearing") + m(MIRBASE:hsa-mir-223) negativeCorrelation path(DOID:"rheumatoid arthritis") - pmid:16820021 + pubmed:30962309 - a(MESH:antalarmin) causesNoChange r(RGD:Bdnf) + m(MIRBASE:hsa-mir-223) negativeCorrelation path(DOID:"multiple sclerosis") - pmid:16820021 + pubmed:30962309 - a(MESH:antalarmin) decreases r(RGD:Ntrk2) + m(MIRBASE:hsa-mir-223) negativeCorrelation path(DOID:"systemic lupus erythematosus") - pmid:16820021 + pubmed:30962309 - a(MESH:antalarmin) increases r(RGD:Ntrk2) + m(MIRBASE:hsa-mir-223) positiveCorrelation p(MESH:"Rheumatoid Factor") - pmid:29807032 + pubmed:30962309 - a(MESH:antalarmin) decreases bp(MESH:"Heat-Shock Response") + bp(GO:"monocyte differentiation") negativeCorrelation m(MIRBASE:hsa-mir-223) - pmid:29807032 + pubmed:30962309 - a(MESH:antalarmin) increases act(p(NCBIGENE:140621)) + bp(GO:"monocyte differentiation") positiveCorrelation p(HGNC:NLRP3) - pmid:29807032 + pubmed:30962309 - a(MESH:antalarmin) causesNoChange a(MESH:"Embryonic Structures") + m(MIRBASE:ebv-mir-BART15) regulates p(HGNC:NLRP3) - pmid:29807032 + pubmed:30962309 - a(MESH:antalarmin) causesNoChange a(MESH:"Embryonic Structures") + m(MIRBASE:ebv-mir-BART15) directlyDecreases p(HGNC:NLRP3) - pmid:23211705 + pubmed:30962309 - a(MESH:antalarmin) increases a(MESH:"Embryonic Structures") + m(MIRBASE:ebv-mir-BART15) increases path(DOID:"multiple sclerosis") + + - pmid:23211705 + pubmed:30962309 - a(MESH:antalarmin) increases a(MESH:Morula) + g(DBSNP:rs10802501) regulates composite(m(MIRBASE:ebv-mir-BART15), m(MIRBASE:hsa-mir-223), r(HGNC:NLRP3)) - pmid:23211705 + pubmed:30962309 - a(MESH:antalarmin) increases a(MESH:Blastocyst) + m(MIRBASE:hsa-mir-7-1) directlyIncreases p(CONSO:"alpha-synuclein aggregates") + + - pmid:23211705 + pubmed:30962309 - a(MESH:antalarmin) decreases act(p(MGI:Crh)) + m(MIRBASE:hsa-mir-7-1) decreases r(HGNC:RELA) - pmid:23211705 + pubmed:30962309 - a(MESH:antalarmin) decreases act(p(MGI:Crh)) + p(CONSO:"alpha-synuclein aggregates") association path(DOID:"Parkinson's disease") + + + + + + - pmid:23211705 + pubmed:26968346 - a(MESH:antalarmin) decreases act(p(MGI:Crh)) + p(CONSO:"alpha-synuclein aggregates") negativeCorrelation bp(GO:"regulation of ER to Golgi vesicle-mediated transport") - pmid:23211705 + pubmed:26968346 - a(MESH:antalarmin) decreases act(p(MGI:Crh)) + p(CONSO:"alpha-synuclein aggregates") negativeCorrelation bp(GO:autophagy) - pmid:23211705 + pubmed:30962309 - a(MESH:antalarmin) regulates p(MGI:Crh) + m(MIRBASE:hsa-mir-30e) directlyIncreases p(CONSO:"alpha-synuclein aggregates") - - - + + + pubmed:30962309 + + path(DOID:"Parkinson's disease") association p(CONSO:"alpha-synuclein aggregates") + - pmid:16820021 + pubmed:30962309 - path(HBP:"isolation rearing") increases p(RGD:Drd2) + path(DOID:"Parkinson's disease") directlyDecreases m(MIRBASE:hsa-mir-7-1) - pmid:16820021 + pubmed:30962309 - path(HBP:"isolation rearing") increases p(RGD:Drd2) + path(DOID:"Parkinson's disease") directlyIncreases m(MIRBASE:hsa-mir-22, loc(GO:"blood microparticle")) - pmid:16820021 + pubmed:30515821 - path(HBP:"isolation rearing") increases p(RGD:Drd3) + path(DOID:"Parkinson's disease") negativeCorrelation path(MESH:"Mitochondrial Dynamics") - pmid:16820021 + pubmed:30515821 - path(HBP:"isolation rearing") increases p(RGD:Drd3) + path(DOID:"Parkinson's disease") negativeCorrelation p(HGNC:PRKN) - pmid:16820021 + pubmed:27190210 - path(HBP:"isolation rearing") decreases r(RGD:Bdnf) + path(DOID:"Parkinson's disease") association bp(GO:"synaptic transmission, cholinergic") - pmid:16820021 + pubmed:22530628 - path(HBP:"isolation rearing") increases r(RGD:Bdnf) + path(DOID:"Parkinson's disease") association p(HGNC:CHRNA7) - pmid:16820021 + pubmed:26979166 - path(HBP:"isolation rearing") decreases r(RGD:Ntrk2) + path(DOID:"Parkinson's disease") increases deg(a(MESH:"Dopaminergic Neurons")) - pmid:16820021 + pubmed:26979166 - path(HBP:"isolation rearing") increases r(RGD:Ntrk2) + path(DOID:"Parkinson's disease") increases deg(a(MESH:"Dopaminergic Neurons")) - pmid:11230871 + pubmed:26979166 - a(CHEBI:neurotransmitter) association bp(GO:cognition) + path(DOID:"Parkinson's disease") increases path(DOID:"anxiety disorder") - pmid:14556719 + pubmed:26979166 - sec(a(CHEBI:neurotransmitter)) association p(HGNC:SYT11, pmod(Ub)) + path(DOID:"Parkinson's disease") increases path(MESH:Depression) - pmid:26813123 + pubmed:26979166 - bp(GO:"response to stress") association bp(GO:"synaptic transmission, cholinergic") + path(DOID:"Parkinson's disease") positiveCorrelation path(MESH:Depression) - pmid:26813123 + pubmed:26979166 - bp(GO:"response to stress") regulates tloc(a(CHEBI:acetylcholine), fromLoc(GO:intracellular), toLoc(MESH:"Basal Forebrain")) + path(DOID:"Parkinson's disease") decreases bp(GO:"learning or memory") - pmid:24563850 + pubmed:26979166 - bp(GO:"response to stress") increases p(HGNCGENEFAMILY:"Small heat shock proteins") + path(DOID:"Parkinson's disease") increases path(HP:Confusion) - pmid:24563850 + pubmed:26979166 - bp(GO:"response to stress") increases p(HGNC:HSF1, pmod(Ph)) + path(DOID:"Parkinson's disease") increases path(DOID:dementia) - pmid:24563850 + pubmed:26979166 - bp(GO:"response to stress") increases p(HGNC:HSF1, loc(MESH:"Cell Nucleus")) + path(DOID:"Parkinson's disease") increases deg(a(MESH:"Cholinergic Neurons")) - pmid:24563850 + pubmed:26979166 - bp(GO:"response to stress") increases act(p(HGNC:HSF1), ma(tscript)) + path(DOID:"Parkinson's disease") decreases p(HGNC:CHAT) - pmid:27181519 + pubmed:26979166 - bp(GO:"response to stress") increases p(HGNC:HDAC6, loc(GO:"cytoplasmic stress granule")) + path(DOID:"Parkinson's disease") negativeCorrelation path(MESH:Smoking) - pmid:26813123 + pubmed:26979166 - bp(GO:"regulation of circadian sleep/wake cycle, wakefulness") association bp(GO:"synaptic transmission, cholinergic") + path(DOID:"Parkinson's disease") negativeCorrelation path(MESH:Smoking) - pmid:26813123 + pubmed:26979166 - bp(GO:"regulation of circadian sleep/wake cycle, sleep") association bp(GO:"synaptic transmission, cholinergic") + path(DOID:"Parkinson's disease") negativeCorrelation path(MESH:Smoking) - pmid:26813123 + pubmed:23516100 - bp(GO:"sensory processing") association bp(GO:"synaptic transmission, cholinergic") + path(DOID:"Parkinson's disease") increases p(HGNC:SNCA, frag("1_119")) - pmid:21482353 + pubmed:23516100 - bp(GO:"sensory processing") association bp(GO:"synaptic transmission, cholinergic") + path(DOID:"Parkinson's disease") increases p(HGNC:SNCA, frag("1_120")) - pmid:24590577 + pubmed:23516100 - bp(GO:"circadian sleep/wake cycle") association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") + path(DOID:"Parkinson's disease") increases p(HGNC:SNCA, frag("1_133")) - pmid:26813123 + pubmed:23516100 - p(HGNC:SLC18A3) increases tloc(a(CHEBI:acetylcholine), fromLoc(GO:cytosol), toLoc(MESH:"Synaptic Vesicles")) + path(DOID:"Parkinson's disease") increases p(HGNC:SNCA, frag("1_122")) - pmid:26813123 + pubmed:23516100 - p(HGNC:SLC18A3) increases tloc(a(CHEBI:acetylcholine), fromLoc(GO:cytosol), toLoc(MESH:"Synaptic Vesicles")) + path(DOID:"Parkinson's disease") negativeCorrelation bp(GO:"calcium ion homeostasis") - pmid:26813123 + pubmed:23516100 - p(HGNC:SLC18A3) increases tloc(a(CHEBI:proton), fromLoc(MESH:"Synaptic Vesicles"), toLoc(GO:cytosol)) + path(DOID:"Parkinson's disease") decreases act(p(HGNCGENEFAMILY:Calpains)) - - - pmid:26813123 + pubmed:23516100 - p(HGNC:CHAT, pmod(Ph)) regulates act(p(HGNC:CHAT)) + path(DOID:"Parkinson's disease") increases act(p(HGNCGENEFAMILY:Calpains)) - pmid:26813123 + pubmed:23516100 - a(CHEBI:"2-(4-phenyl-1-piperidinyl)-1-cyclohexanol") decreases act(p(HGNC:SLC18A3)) + path(DOID:"Parkinson's disease") increases complex(p(HGNC:SNCA), p(HGNCGENEFAMILY:Calpains)) - pmid:26813123 + pubmed:21861815 - a(CHEBI:"2-(4-phenyl-1-piperidinyl)-1-cyclohexanol") decreases tloc(a(CHEBI:acetylcholine), fromLoc(GO:cytosol), toLoc(MESH:"Synaptic Vesicles")) + path(DOID:"Parkinson's disease") negativeCorrelation act(p(MESH:"Hypoxia-Inducible Factor 1")) - pmid:26813123 + pubmed:26968346 - p(MGI:Slc18a3) decreases path(MESH:"Neuromuscular Diseases") + path(DOID:"Parkinson's disease") decreases p(HGNC:TFEB, loc(GO:nucleus)) - pmid:26813123 + pubmed:27299292 - p(MGI:Slc18a3) increases bp(GO:cognition) + path(DOID:"Parkinson's disease") decreases p(HGNC:TFEB, loc(GO:nucleus)) - pmid:26813123 + pubmed:26968346 - a(CHEBI:"organophosphorus compound") decreases act(p(HGNC:ACHE)) + path(DOID:"Parkinson's disease") increases composite(p(HGNC:SNCA), p(HGNC:TFEB), loc(GO:"Lewy body")) - pmid:26813123 + pubmed:27299292 - a(CHEBI:antidote) increases act(p(HGNC:ACHE)) + path(DOID:"Parkinson's disease") decreases a(MESH:Lysosomes) - pmid:26813123 + pubmed:27299292 - a(CHEBI:doxylamine) increases act(p(HGNC:ACHE)) + path(DOID:"Parkinson's disease") increases complex(p(HGNC:SNCA), p(HGNC:TFEB)) - pmid:26813123 + pubmed:27299292 - a(CHEBI:succinylcholine) decreases act(p(HGNC:ACHE)) + path(DOID:"Parkinson's disease") positiveCorrelation m(MIRBASE:hsa-mir-128-1) - pmid:26813123 + pubmed:30562574 - p(MGI:Slc5a7) decreases path(MESH:Death) + path(DOID:"Parkinson's disease") association bp(GO:"chaperone-mediated autophagy") - + + + pubmed:30562574 + + path(DOID:"Parkinson's disease") association p(HGNC:PARK7) + - pmid:26813123 + pubmed:30562574 - complex(a(GO:"plasma membrane"), p(HGNC:SLC5A7)) association bp(GO:"action potential initiation") + path(DOID:"Parkinson's disease") association p(HGNC:PARK7) - pmid:26813123 + pubmed:23384725 - a(MESH:"Basal Nucleus of Meynert") negativeCorrelation path(MESH:"Alzheimer Disease") + path(DOID:"Parkinson's disease") association composite(a(MESH:"Inclusion Bodies"), p(HGNC:TARDBP)) - pmid:26813123 + pubmed:30962309 - p(FPLX:CHRN, pmod(Ph)) regulates act(p(FPLX:CHRN)) + composite(m(MIRBASE:hsa-mir-7-1), p(CONSO:"alpha-synuclein aggregates")) increases path(DOID:"Parkinson's disease") - pmid:26813123 + pubmed:30962309 - a(MESH:"Protein-Tyrosine Kinases") increases p(FPLX:CHRN, pmod(Ph)) + composite(m(MIRBASE:hsa-mir-30e), p(CONSO:"alpha-synuclein aggregates")) increases path(DOID:"Parkinson's disease") - + + + pubmed:22372633 + + path(DOID:"neurodegenerative disease") negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + - pmid:26813123 + pubmed:22372633 - complex(a(CHEBI:"1,1-dimethyl-4-phenylpiperazinium iodide"), p(FPLX:CHRN)) increases act(p(FPLX:CHRN)) + path(DOID:"neurodegenerative disease") negativeCorrelation p(HGNC:HDAC6) - + + + pubmed:30515821 + + path(DOID:"neurodegenerative disease") negativeCorrelation path(MESH:"Mitochondrial Dynamics") + - pmid:26813123 + pubmed:30515821 - complex(a(CHEBI:cystine), p(FPLX:CHRN)) increases act(p(FPLX:CHRN)) + path(DOID:"neurodegenerative disease") association p(HGNC:MAPK1) - pmid:22020111 + pubmed:23516100 - a(CHEBI:cystine) increases a(CHEBI:glutathione) + path(DOID:"neurodegenerative disease") positiveCorrelation p(HGNC:MAPT, frag("?")) - + + + pubmed:23516100 + + path(DOID:"neurodegenerative disease") positiveCorrelation p(HGNC:MAPT, frag("1_421")) + - pmid:26813123 + pubmed:23516100 - complex(a(CHEBI:nicotine), p(FPLX:CHRN)) increases act(p(FPLX:CHRN)) + path(DOID:"neurodegenerative disease") negativeCorrelation bp(GO:"calcium ion homeostasis") - pmid:11230871 + pubmed:23516100 - complex(a(CHEBI:nicotine), p(FPLX:CHRN)) association bp(GO:cognition) + path(DOID:"neurodegenerative disease") decreases act(p(HGNCGENEFAMILY:Calpains)) - pmid:26813123 + pubmed:27299292 - a(CHEBI:tubocurarine) decreases act(p(FPLX:CHRN)) + path(DOID:"neurodegenerative disease") negativeCorrelation act(p(HGNC:TFEB)) - pmid:29626319 + pubmed:27299292 - a(MESH:"Receptors, G-Protein-Coupled") increases deg(a(CHEBI:"amyloid-beta")) + path(DOID:"neurodegenerative disease") negativeCorrelation p(HGNC:TFEB) - + + + pubmed:28669544 + + path(DOID:"neurodegenerative disease") association path(MESH:"Protein Aggregation, Pathological") + - pmid:26813123 + pubmed:28669544 - complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) increases act(p(FPLX:PLC)) + path(DOID:"neurodegenerative disease") association path(MESH:"Neuronal Plasticity") - pmid:26813123 + pubmed:28669544 - complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(CHEBI:"myo-inositol") + path(DOID:"neurodegenerative disease") association a(MESH:Microglia) - pmid:26813123 + pubmed:30988501 - complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) decreases act(a(MESH:"Potassium Channels")) + path(DOID:"neurodegenerative disease") positiveCorrelation bp(GO:pathogenesis) - pmid:26813123 + pubmed:30962309 - complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(MESH:"Receptors, N-Methyl-D-Aspartate") + m(MIRBASE:hsa-mir-20b) regulates act(p(HGNC:NLRP3)) - pmid:26813123 + pubmed:30962309 - complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) negativeCorrelation path(MESH:"Alzheimer Disease") + m(MIRBASE:hsa-mir-20b) directlyIncreases path(MESH:Inflammation) - pmid:26813123 + pubmed:30962309 - complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) increases bp(GO:cognition) + m(MIRBASE:hsa-mir-22) decreases r(HGNC:NLRP3) - + + + pubmed:30962309 + + m(MIRBASE:hsa-mir-22) negativeCorrelation path(DOID:"coronary artery disease") + - pmid:26813123 + pubmed:30962309 - complex(p(HGNC:CHRM3), p(INTERPRO:"G-protein alpha subunit, group Q")) increases act(p(FPLX:PLC)) + m(MIRBASE:hsa-mir-22) positiveCorrelation path(MESH:"Cell Survival") - pmid:26813123 + pubmed:30962309 - complex(p(HGNC:CHRM3), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(CHEBI:"myo-inositol") + path(DOID:"coronary artery disease") negativeCorrelation m(MIRBASE:hsa-mir-22) - pmid:26813123 + pubmed:30962309 - complex(p(HGNC:CHRM3), p(INTERPRO:"G-protein alpha subunit, group Q")) decreases act(a(MESH:"Potassium Channels")) + path(MESH:"Cell Survival") positiveCorrelation m(MIRBASE:hsa-mir-22) - pmid:26813123 + pubmed:30740335 - complex(p(HGNC:CHRM3), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(MESH:"Receptors, N-Methyl-D-Aspartate") + path(MESH:"Cell Survival") association path(MESH:"Unfolded Protein Response") - + + + pubmed:30837838 + + path(MESH:"Cell Survival") association bp(GO:"vacuole fusion") + - pmid:26813123 + pubmed:30837838 - complex(p(HGNC:CHRM5), p(INTERPRO:"G-protein alpha subunit, group Q")) increases act(p(FPLX:PLC)) + path(MESH:"Cell Survival") association path(MESH:"Endoplasmic Reticulum-Associated Degradation") - pmid:26813123 + pubmed:30962309 - complex(p(HGNC:CHRM5), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(CHEBI:"myo-inositol") + m(MIRBASE:hsa-mir-133b) association r(HGNC:NLRP3) - pmid:26813123 + pubmed:30962309 - complex(p(HGNC:CHRM5), p(INTERPRO:"G-protein alpha subunit, group Q")) decreases act(a(MESH:"Potassium Channels")) + m(MIRBASE:hsa-mir-133b) decreases path(DOID:"allergic rhinitis") - pmid:26813123 + pubmed:30962309 - complex(p(HGNC:CHRM5), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(MESH:"Receptors, N-Methyl-D-Aspartate") + path(DOID:"allergic rhinitis") decreases m(MIRBASE:hsa-mir-133b) - + + + pubmed:30962309 + + path(DOID:"allergic rhinitis") decreases path(HP:"Myocardial immune cell infiltration") + - pmid:26813123 + pubmed:30962309 - complex(p(HGNC:CHRM2), p(INTERPRO:"G-protein alpha subunit, group I")) decreases p(FPLX:ADCY) + path(DOID:"allergic rhinitis") decreases a(MESH:Cytokines) - pmid:26813123 + pubmed:30962309 - complex(p(HGNC:CHRM2), p(INTERPRO:"G-protein alpha subunit, group I")) decreases a(CHEBI:"3',5'-cyclic AMP") + path(DOID:"allergic rhinitis") decreases complex(GO:"NLRP3 inflammasome complex") - pmid:26813123 + pubmed:30962309 - complex(p(HGNC:CHRM2), p(INTERPRO:"G-protein alpha subunit, group I")) decreases act(a(MESH:"Calcium Channels")) + path(DOID:"trigeminal neuralgia") decreases m(MIRBASE:hsa-mir-186) - + + + pubmed:27889190 + + path(DOID:"trigeminal neuralgia") association path(DOID:"relapsing-remitting multiple sclerosis") + - pmid:26813123 + pubmed:30962309 - complex(p(HGNC:CHRM4), p(INTERPRO:"G-protein alpha subunit, group I")) decreases p(FPLX:ADCY) + path(MESH:Neuralgia) negativeCorrelation r(HGNC:NLRP3) - pmid:26813123 + pubmed:30962309 - complex(p(HGNC:CHRM4), p(INTERPRO:"G-protein alpha subunit, group I")) decreases a(CHEBI:"3',5'-cyclic AMP") + path(MESH:Neuralgia) negativeCorrelation act(complex(GO:"NLRP3 inflammasome complex")) - pmid:26813123 + pubmed:30962309 - complex(p(HGNC:CHRM4), p(INTERPRO:"G-protein alpha subunit, group I")) decreases act(a(MESH:"Calcium Channels")) + path(DOID:"myocardial infarction") decreases m(MIRBASE:hsa-mir-495) @@ -74718,2629 +75382,2731 @@

Statements

- pmid:26088141 + pubmed:30962309 - act(a(MESH:"Calcium Channels")) association act(a(CHEBI:choline)) + path(EFO:"ischemia reperfusion injury") decreases m(MIRBASE:hsa-mir-495) - pmid:26088141 + pubmed:30962309 - act(a(MESH:"Calcium Channels")) association a(CHEBI:"calcium(2+)") + composite(m(MIRBASE:hsa-mir-495), r(HGNC:NLRP3)) increases path(MESH:Inflammation) - + + + pubmed:30962309 + + m(MIRBASE:hsa-mir-214) decreases p(HGNC:CASP1) + - pmid:26813123 + pubmed:30962309 - complex(a(CHEBI:Muscarine), p(FPLX:CHRM)) increases act(p(FPLX:CHRM)) + path(HP:"Anterior cortical cataract") directlyDecreases m(MIRBASE:hsa-mir-214) - pmid:26813123 + pubmed:30962309 - a(MESH:"Quinuclidinyl Benzilate") decreases act(p(FPLX:CHRM)) + m(MIRBASE:hsa-mir-371a) association p(HGNC:CASP8, loc(GO:"inflammasome complex")) - pmid:26813123 + pubmed:30962309 - a(MESH:"Receptors, Cholinergic") increases bp(GO:memory) + m(MIRBASE:hsa-mir-373) association p(HGNC:CASP8, loc(GO:"inflammasome complex")) - pmid:25514383 + pubmed:30962309 - a(MESH:"Receptors, Cholinergic") increases path(MESH:Attention) + m(MIRBASE:hsa-mir-543) association p(HGNC:CASP8, loc(GO:"inflammasome complex")) - pmid:26813123 + pubmed:30962309 - path(MESH:Apathy) positiveCorrelation path(MESH:"Alzheimer Disease") + path(DOID:"hepatocellular carcinoma") directlyIncreases m(MIRBASE:hsa-mir-371a) - pmid:26813123 + pubmed:30962309 - p(MGI:Chrm4) decreases tloc(a(CHEBI:dopamine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) + path(DOID:"hepatocellular carcinoma") directlyIncreases m(MIRBASE:hsa-mir-373) - pmid:24590577 + pubmed:30962309 - p(MGI:Chrm4) decreases act(a(CHEBI:phencyclidine)) + path(DOID:"hepatocellular carcinoma") directlyIncreases m(MIRBASE:hsa-mir-543) - pmid:24590577 + pubmed:30962309 - p(MGI:Chrm4) decreases bp(GO:"locomotor rhythm") + m(MIRBASE:hsa-mir-34a) regulates p(HGNC:CASP4) - pmid:24590577 + pubmed:30962309 - p(MGI:Chrm4) decreases act(p(MGI:Drd1)) + m(MIRBASE:hsa-mir-34a) regulates p(HGNC:CASP5) - pmid:26813123 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") negativeCorrelation a(MESH:"Cholinergic Neurons") + m(MIRBASE:hsa-mir-451a) regulates p(HGNC:CASP4) - pmid:22020111 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation a(HBP:"protein aggregates") + m(MIRBASE:hsa-mir-451a) regulates p(HGNC:CASP5) - pmid:12428809 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation a(MESH:"Intermediate Filaments") + m(MIRBASE:hsa-mir-874) regulates p(HGNC:CASP4) - pmid:21722302 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") association path(HBP:Neurodegeneration) + m(MIRBASE:hsa-mir-874) regulates p(HGNC:CASP5) - pmid:21722302 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") association path(HBP:Neurodegeneration) + m(MIRBASE:hsa-mir-34c) negativeCorrelation p(OMIT:0016854) - pmid:21722302 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") association a(HBP:"Motor Neurons") + m(MIRBASE:hsa-mir-34c) decreases p(HGNCGENEFAMILY:"Toll like receptors") - pmid:21722302 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") increases bp(HBP:"protein aggregation") + m(MIRBASE:hsa-mir-34c) decreases p(HGNC:IL1R1) - pmid:21722302 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") association a(GO:"Bunina body") + m(MIRBASE:hsa-mir-34c) decreases r(HGNC:IKBKG) - pmid:21722302 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") association a(GO:"neurofilament cytoskeleton") + m(MIRBASE:hsa-mir-34c) negativeCorrelation path(EFO:"induces sterile inflammation") - pmid:21722302 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") association a(CHEBI:ubiquitin) + m(MIRBASE:hsa-mir-34c) decreases path(MESH:Inflammation) - pmid:21722302 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") association p(MESH:"Superoxide Dismutase-1", var("?")) + p(OMIT:0016854) negativeCorrelation m(MIRBASE:hsa-mir-34c) - pmid:21722302 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNCGENEFAMILY:"Protein disulfide isomerases") + p(OMIT:0016854) negativeCorrelation m(MIRBASE:hsa-mir-146a) - pmid:21722302 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") association a(MESH:"Superoxide Dismutase-1") + p(OMIT:0016854) negativeCorrelation m(MIRBASE:hsa-mir-155) - pmid:21722302 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") association bp(GO:"ERAD pathway") + p(OMIT:0016854) negativeCorrelation m(MIRBASE:hsa-mir-302b) - pmid:21722302 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:VAPB, var("?")) + p(OMIT:0016854) negativeCorrelation m(MIRBASE:hsa-mir-330) - pmid:21722302 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") association p(MESH:"TARBP1 protein, human") + p(OMIT:0016854) increases r(HGNC:NLRP3) - pmid:21722302 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:ERN1) + p(OMIT:0016854) increases r(HGNC:NLRP3) - pmid:21722302 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") association p(MESH:"PERK kinase") + p(OMIT:0016854) increases r(HGNC:IL1B) - pmid:21722302 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:ATF6) + p(OMIT:0016854) increases r(HGNC:IL1B) + + - pmid:25784053 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") negativeCorrelation p(HGNC:ATF6) + m(MIRBASE:hsa-mir-302b) negativeCorrelation p(OMIT:0016854) - pmid:29758300 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation p(HGNC:TARDBP, pmod(HBP:misfolding)) + m(MIRBASE:hsa-mir-302b) decreases p(HGNCGENEFAMILY:"Toll like receptors") - pmid:29758300 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") negativeCorrelation bp(GO:macroautophagy) + m(MIRBASE:hsa-mir-302b) decreases p(HGNC:IL1R1) - pmid:14556719 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") decreases a(MESH:"Brain Stem") + m(MIRBASE:hsa-mir-302b) directlyDecreases p(HGNC:IRAK4) - pmid:14556719 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") decreases bp(GO:"spinal cord development") + m(MIRBASE:hsa-mir-302b) directlyDecreases r(HGNC:NLRP3) - pmid:14556719 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") decreases a(MESH:"Pyramidal Tracts") + m(MIRBASE:hsa-mir-330) negativeCorrelation p(OMIT:0016854) - pmid:14556719 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") increases path(MESH:Paralysis) + m(MIRBASE:hsa-mir-330) decreases p(OMIT:0016854) - pmid:14556719 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") increases bp(GO:"neuron death") + m(MIRBASE:hsa-mir-330) decreases p(HGNCGENEFAMILY:"Tumor necrosis factor receptor superfamily") - pmid:14556719 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:SOD1, var("?")) + m(MIRBASE:hsa-mir-330) decreases p(HGNC:NLRP3) - pmid:14556719 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:RNF19A) + m(MIRBASE:hsa-mir-330) decreases p(HGNC:IL1B) - pmid:14556719 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation p(HGNC:UBL5) + m(MIRBASE:hsa-mir-330) decreases bp(GO:"sphingosine-1-phosphate receptor signaling pathway") - pmid:22908190 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation p(HGNC:TARDBP, pmod(Ub)) + m(MIRBASE:hsa-mir-330) decreases bp(GO:"sphingosine-1-phosphate receptor signaling pathway") - pmid:22908190 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation p(HGNC:TARDBP, pmod(Ub)) + m(MIRBASE:hsa-mir-330) decreases r(HGNC:NLRP3) - pmid:25784053 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") increases bp(GO:autophagy) + p(HGNCGENEFAMILY:"Toll like receptors") increases p(OMIT:0016854) - pmid:27181519 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") negativeCorrelation bp(GO:autophagy) + p(HGNC:IL1R1) increases p(OMIT:0016854) - pmid:27181519 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") decreases bp(GO:autophagy) + p(HGNC:IL1R1) increases p(HGNC:IRAK4) - pmid:26702100 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") association bp(GO:autophagy) + p(HGNCGENEFAMILY:"Tumor necrosis factor receptor superfamily") increases p(OMIT:0016854) - pmid:30116051 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") association path(MESH:"Frontotemporal Dementia") + p(HGNC:MYD88) increases p(HGNC:IRAK1) - pmid:30116051 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:SQSTM1) + p(HGNC:MYD88) decreases path(MESH:Depression) - pmid:30116051 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:CHMP2B) + p(HGNC:IRAK1) increases p(OMIT:0016854) - pmid:30116051 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:TBK1) + p(HGNC:IRAK1) increases r(HGNC:NLRP3) - pmid:27181519 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:TBK1) + p(HGNC:IRAK1) increases r(HGNC:PYCARD) - pmid:30116051 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:OPTN) + p(HGNC:IRAK1) increases r(HGNC:CASP1) - pmid:27181519 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:OPTN) + p(HGNC:IRAK1) increases p(HGNC:NLRP3) - pmid:29980653 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") isA path(MESH:"Neurodegenerative Diseases") + p(HGNC:IRAK1) increases p(HGNC:PYCARD) - pmid:29980653 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation p(HGNC:TARDBP) + p(HGNC:IRAK1) increases p(HGNC:CASP1) - pmid:27181519 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") isA path(MESH:"Motor Neuron Disease") + p(HGNC:IRAK4) increases p(HGNC:TRAF6) - pmid:27181519 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation bp(GO:"motor neuron apoptotic process") + p(HGNC:IRAK4) directlyIncreases r(HGNC:NLRP3) - pmid:27181519 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") negativeCorrelation bp(HBP:Proteostasis) + p(HGNCGENEFAMILY:"IKK complex") increases p(OMIT:0016854) - pmid:27181519 + pubmed:30962309 - path(MESH:"Amyotrophic Lateral Sclerosis") association g(HGNC:SOD1) + a(PUBCHEM:23697816) increases a(MESH:Macrophages) - pmid:27181519 + pubmed:30935091 - path(MESH:"Amyotrophic Lateral Sclerosis") negativeCorrelation a(CHEBI:"all-trans-retinoic acid") + path(MESH:Depression) positiveCorrelation p(HGNC:HDAC6) - pmid:27181519 + pubmed:22950410 - path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation complex(GO:"cytoplasmic stress granule", loc(MESH:"Motor Neurons")) + path(MESH:Depression) association p(HGNC:CRHR1) - pmid:27181519 + pubmed:16340157 - path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation p(HGNC:TARDBP, var("?")) + path(MESH:Depression) positiveCorrelation a(NIFT:"Grey matter atrophy") - pmid:27181519 + pubmed:17009926 - path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation p(HGNC:FUS, var("?")) + path(MESH:Depression) association p(FPLX:CHRN) - pmid:27181519 + pubmed:11230871 - path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:MATR3) + path(MESH:Depression) association p(FPLX:CHRN) - pmid:27181519 + pubmed:26813123 - path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:HNRNPA2B1) + path(MESH:Depression) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27181519 + pubmed:26979166 - path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:HNRNPA1) + path(MESH:Depression) positiveCorrelation path(DOID:"diabetes mellitus") - pmid:27181519 + pubmed:26979166 - path(MESH:"Amyotrophic Lateral Sclerosis") association g(HGNC:C9orf72, var("?")) + path(MESH:Depression) positiveCorrelation path(DOID:obesity) - pmid:27181519 + pubmed:26979166 - path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:OPTN, var("p.Glu478Gly")) + path(MESH:Depression) positiveCorrelation path(DOID:"cardiovascular system disease") - pmid:27181519 + pubmed:26979166 - path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:UBQLN2, var("?")) + path(MESH:Depression) positiveCorrelation path(MESH:Smoking) - pmid:27181519 + pubmed:26979166 - path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:OPTN, var("?")) + path(MESH:Depression) positiveCorrelation path(MESH:Alcoholism) - pmid:27181519 + pubmed:26979166 - path(MESH:"Amyotrophic Lateral Sclerosis") negativeCorrelation act(p(HGNC:HDAC6)) + path(MESH:Depression) positiveCorrelation bp(GO:"microglial cell activation") - pmid:27181519 + pubmed:26979166 - path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:SQSTM1, var("?")) + path(MESH:Depression) positiveCorrelation path(DOID:"Parkinson's disease") - pmid:26813123 + pubmed:21482353 - path(MESH:"Supranuclear Palsy, Progressive") negativeCorrelation a(MESH:"Cholinergic Neurons") + path(MESH:Depression) association bp(GO:"synaptic transmission, cholinergic") - pmid:29758300 + pubmed:19721446 - path(MESH:"Supranuclear Palsy, Progressive") association p(HGNC:MAPT) + path(MESH:Depression) increases a(CHEBI:choline) - pmid:30126037 + pubmed:28901280 - path(MESH:"Supranuclear Palsy, Progressive") association p(HGNC:MAPT) + path(MESH:Depression) association p(MESH:"Receptors, Nicotinic") - pmid:30126037 + pubmed:29687724 - path(MESH:"Supranuclear Palsy, Progressive") increases a(HBP:HBP00045) + path(MESH:Depression) association path(MESH:"Huntington Disease") - pmid:30126037 + pubmed:30962309 - path(MESH:"Supranuclear Palsy, Progressive") increases a(GO:"neurofibrillary tangle") + path(NCIT:C118474) directlyIncreases m(MIRBASE:hsa-mir-34c, loc(NCIT:C12954)) - pmid:11089576 + pubmed:30962309 - path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation a(GO:"neurofibrillary tangle") + path(EFO:"induces sterile inflammation") negativeCorrelation m(MIRBASE:hsa-mir-34c) - pmid:30126037 + pubmed:30962309 - path(MESH:"Supranuclear Palsy, Progressive") increases bp(HP:Neurodegeneration) + p(HGNC:IL1R2) directlyDecreases bp(GO:"interleukin-1-mediated signaling pathway") - pmid:30126037 + pubmed:30962309 - path(MESH:"Supranuclear Palsy, Progressive") increases path(MESH:Gliosis) + m(MIRBASE:hsa-mir-383) decreases p(HGNC:IL1R2) - pmid:30126037 + pubmed:30962309 - path(MESH:"Supranuclear Palsy, Progressive") increases path(MESH:"Motor Disorders") + m(MIRBASE:hsa-mir-383) decreases p(HGNC:CASP1) - pmid:30126037 + pubmed:30962309 - path(MESH:"Supranuclear Palsy, Progressive") association path(MESH:"Parkinsonian Disorders") + m(MIRBASE:hsa-mir-383) decreases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:30126037 + pubmed:30962309 - path(MESH:"Supranuclear Palsy, Progressive") association path(MESH:Tauopathies) + m(MIRBASE:hsa-mir-383) decreases tloc(p(HGNC:IL18), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:29311797 + pubmed:30962309 - path(MESH:"Supranuclear Palsy, Progressive") isA path(MESH:Tauopathies) + path(DOID:atherosclerosis) decreases m(MIRBASE:hsa-mir-383) - pmid:30126037 + pubmed:30962309 - path(MESH:"Supranuclear Palsy, Progressive") increases path(MESH:"Cognitive Dysfunction") + path(DOID:atherosclerosis) increases p(HGNC:IL1R2) - pmid:30126037 + pubmed:30962309 - path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HGNC:CDKN2A) + path(EFO:"endothelial dysfunction") directlyIncreases m(MIRBASE:hsa-mir-383) - pmid:29191965 + pubmed:30962309 - path(MESH:"Supranuclear Palsy, Progressive") association p(HGNC:MAPT, var("p.Ala152Thr")) + composite(p(HGNC:TNF), p(HGNC:TNFRSF1A)) increases p(HGNC:TRAF2) + + - pmid:26631930 + pubmed:27794524 - path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HGNC:MAPT, var("p.Ala152Thr")) + p(HGNC:TNFRSF1A, loc(MESH:Neurons)) increases bp(GO:"neuron death") - pmid:28420982 + pubmed:30962309 - path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation a(HBP:"Tau oligomers") + p(HGNC:TRAF2) increases p(HGNC:SPHK1) - pmid:26631930 + pubmed:22110360 - path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation a(HBP:"Tau oligomers") + p(HGNC:TRAF2) increases act(p(HGNC:MAP3K5)) + + - pmid:26751493 + pubmed:30962309 - path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HBP:"4R tau") + p(HGNC:SPHK1) increases bp(GO:"sphingosine-1-phosphate receptor signaling pathway") - pmid:26631930 + pubmed:30962309 - path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HBP:"4R tau") + bp(GO:"sphingosine-1-phosphate receptor signaling pathway") increases act(p(OMIT:0016854)) - pmid:26631930 + pubmed:30962309 - path(MESH:"Supranuclear Palsy, Progressive") negativeCorrelation g(HGNC:MIR132) + bp(GO:"sphingosine-1-phosphate receptor signaling pathway") increases r(HGNC:NLRP3) - pmid:26631930 + pubmed:30962309 - path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HGNC:SRSF2) + bp(GO:"sphingosine-1-phosphate receptor signaling pathway") increases r(HGNC:NLRP3) - pmid:26631930 + pubmed:30962309 - path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 280)) + a(CHEBI:fructose) increases bp(GO:"sphingosine-1-phosphate receptor signaling pathway") - pmid:12578227 + pubmed:30962309 - path(MESH:"Supranuclear Palsy, Progressive") increases p(HGNC:TGM1) + a(CHEBI:fructose) increases p(OMIT:0016854) - pmid:12578227 + pubmed:30962309 - path(MESH:"Supranuclear Palsy, Progressive") increases r(HGNC:TGM1) + a(CHEBI:fructose) increases p(HGNC:NLRP3) - pmid:12578227 + pubmed:30962309 - path(MESH:"Supranuclear Palsy, Progressive") increases p(HBP:"TGM2 Isoform 3 (349 aa)") + a(CHEBI:fructose) increases p(HGNC:IL1B) - pmid:12578227 + pubmed:30962309 - path(MESH:"Supranuclear Palsy, Progressive") increases r(HGNC:TGM2) + a(CHEBI:fructose) increases m(MIRBASE:hsa-mir-377) - pmid:11089576 + pubmed:30962309 - path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation act(p(ECCODE:"2.3.2.13")) + p(HGNC:IFNAR1) association a(PUBCHEM:223370366) - pmid:22057784 + pubmed:30962309 - path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) + p(HGNC:IFNAR1) association a(NCIT:C20494) - pmid:17050703 + pubmed:30962309 - path(MESH:"Supranuclear Palsy, Progressive") association p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) + p(HGNC:IFNAR1) increases bp(GO:"receptor signaling pathway via JAK-STAT") - pmid:29281045 + pubmed:30962309 - path(MESH:"Supranuclear Palsy, Progressive") decreases p(FPLX:PPP2, pmod(Me)) + p(HGNC:IFNAR1) increases act(complex(GO:"ISGF3 complex")) - pmid:29281045 + pubmed:30962309 - path(MESH:"Supranuclear Palsy, Progressive") decreases p(HGNC:LCMT1) + p(HGNC:IFNAR1) increases r(HGNC:NLRP3) - pmid:29281045 + pubmed:23702978 - path(MESH:"Supranuclear Palsy, Progressive") increases p(HGNC:PPME1) + act(p(HGNC:IFNAR1)) increases act(p(HGNC:SCAF11)) - pmid:26813123 + pubmed:23702978 - path(MESH:"Olivopontocerebellar Atrophies") negativeCorrelation a(MESH:"Cholinergic Neurons") + p(HGNC:IFNAR1) increases act(p(HGNC:SCAF11)) - pmid:26813123 + pubmed:30962309 - act(a(GO:"cholinergic synapse")) association a(HBP:"amyloid-beta oligomers") + a(NCIT:C20494) association p(HGNC:IFNAR1) - + + + pubmed:30962309 + + bp(GO:"receptor signaling pathway via JAK-STAT") increases r(HGNC:NLRP3) + - pmid:26813123 + pubmed:19126755 - complex(a(MESH:"Amyloid beta-Peptides"), p(HGNC:ACHE)) increases a(HBP:"amyloid-beta fibrils") + bp(GO:"receptor signaling pathway via JAK-STAT") increases act(a(CHEBI:nicotine)) - pmid:26813123 + pubmed:27190210 - p(MGI:App, var("?")) decreases tloc(a(CHEBI:choline), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + bp(GO:"receptor signaling pathway via JAK-STAT") decreases tloc(a(MESH:Cytokines), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:26813123 + pubmed:27190210 - p(MGI:App, var("?")) decreases p(FPLX:CHRM) + bp(GO:"receptor signaling pathway via JAK-STAT") decreases path(MESH:Inflammation) - pmid:26813123 + pubmed:27190210 - p(MGI:App, var("?")) decreases p(FPLX:CHRN) + bp(GO:"receptor signaling pathway via JAK-STAT") increases p(HGNC:HMOX1) - pmid:22419736 + pubmed:30962309 - p(MGI:App, var("?")) increases p(MGI:Ak1) + act(complex(GO:"ISGF3 complex")) increases r(HGNC:NLRP3) - pmid:26813123 + pubmed:30962309 - a(PUBCHEM:10013505) increases act(p(HGNC:CHRM1)) + m(MIRBASE:hsa-mir-9-1) decreases p(HGNC:JAK1) - pmid:26813123 + pubmed:30962309 - a(PUBCHEM:10013505) increases bp(GO:cognition) + m(MIRBASE:hsa-mir-9-1) regulates path(MESH:Inflammation) - pmid:26813123 + pubmed:30962309 - a(PUBCHEM:10013505) decreases a(CHEBI:"amyloid-beta polypeptide 42") + m(MIRBASE:hsa-mir-9-1) directlyDecreases r(HGNC:NLRP3) - pmid:26813123 + pubmed:30962309 - a(PUBCHEM:10013505) decreases p(HGNC:MAPT, var("?")) + m(MIRBASE:hsa-mir-9-1) decreases r(HGNC:NFKB1) - pmid:26813123 + pubmed:30962309 - a(PUBCHEM:10013505) increases a(MESH:"Amyloid Precursor Protein Secretases") + a(CHEBI:"oxidised LDL") increases m(MIRBASE:hsa-mir-9-1) + + - pmid:24653673 + pubmed:30962309 - p(HGNC:MAPT, var("?")) decreases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:MAPT)) + p(HGNC:SOD1) decreases a(CHEBI:"reactive oxygen species") + + + + + + + + + + + + - pmid:22299660 + pubmed:14556719 - p(HGNC:MAPT, var("?")) association path(MESH:"Frontotemporal Dementia") + p(HGNC:SOD1) decreases bp(GO:"response to oxidative stress") + + + + + + + + - pmid:30116051 + pubmed:24563850 - p(HGNC:MAPT, var("?")) decreases act(complex(GO:"proteasome complex")) + p(HGNC:SOD1) increases rxn(reactants(a(CHEBI:superoxide)), products(a(CHEBI:"hydrogen peroxide"), a(CHEBI:dioxygen))) + + + + - pmid:30116051 + pubmed:30837838 - p(HGNC:MAPT, var("?")) decreases deg(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) + p(HGNC:SOD1) association path(MESH:"Amyotrophic Lateral Sclerosis") + + - pmid:30116051 + pubmed:30962309 - p(HGNC:MAPT, var("?")) decreases deg(a(HBP:"Tau oligomers")) + m(MIRBASE:hsa-mir-377) decreases p(HGNC:SOD1) - pmid:30116051 + pubmed:30962309 - p(HGNC:MAPT, var("?")) decreases bp(GO:"chaperone-mediated autophagy") + m(MIRBASE:hsa-mir-377) decreases p(HGNC:SOD2) - pmid:29215007 + pubmed:30962309 - p(HGNC:MAPT, var("?")) positiveCorrelation path(MESH:"Alzheimer Disease") + m(MIRBASE:hsa-mir-377) increases a(CHEBI:"reactive oxygen species") - pmid:21734277 + pubmed:30962309 - p(HGNC:MAPT, var("?")) increases p(HBP:"phosphatase-activating domain") + m(MIRBASE:hsa-mir-377) increases p(HGNC:NLRP3) - pmid:29988016 + pubmed:30962309 - act(p(HGNC:MAPT, var("?"))) increases a(HBP:"Tau aggregates") + m(MIRBASE:hsa-mir-377) increases p(HGNC:PYCARD) - pmid:29988016 + pubmed:30962309 - act(p(HGNC:MAPT, var("?"))) increases a(HBP:"Tau aggregates") + m(MIRBASE:hsa-mir-377) increases p(HGNC:CASP1) - pmid:21882945 + pubmed:30962309 - p(HGNC:MAPT, var("?")) increases a(HBP:"Tau aggregates") + m(MIRBASE:hsa-mir-377) increases p(HGNC:IL1B) - pmid:26631930 + pubmed:30962309 - p(HGNC:MAPT, var("?")) increases a(HBP:"Tau aggregates") + m(MIRBASE:hsa-mir-377) association path(EFO:"metabolic syndrome") - pmid:21882945 + pubmed:30962309 - p(HGNC:MAPT, var("?")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + path(EFO:"metabolic syndrome") association m(MIRBASE:hsa-mir-377) - pmid:26631930 + pubmed:30962309 - p(HGNC:MAPT, var("?")) increases tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) + m(MIRBASE:hsa-mir-17) decreases p(HGNC:TXNIP) - pmid:26631930 + pubmed:30962309 - p(HGNC:MAPT, var("?")) decreases act(a(GO:synapse)) + m(MIRBASE:hsa-mir-17) decreases p(HGNC:TXNIP) - pmid:26813123 + pubmed:30962309 - a(PUBCHEM:9867750) increases tloc(a(CHEBI:acetylcholine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) + m(MIRBASE:hsa-mir-17) decreases p(HGNC:NLRP3) - pmid:26813123 + pubmed:30962309 - a(PUBCHEM:9867750) increases act(p(HGNC:CHRM1)) + m(MIRBASE:hsa-mir-17) regulates complex(MESH:Inflammasomes) - pmid:26813123 + pubmed:30962309 - a(PUBCHEM:9867750) increases act(a(MESH:"Receptors, Nicotinic")) + m(MIRBASE:hsa-mir-148a) decreases p(HGNC:TXNIP) - pmid:26813123 + pubmed:30962309 - a(PUBCHEM:9867750) increases bp(GO:cognition) + m(MIRBASE:hsa-mir-148a) decreases p(HGNC:TXNIP) - pmid:26813123 + pubmed:30962309 - a(PUBCHEM:1476756) increases bp(GO:"excitatory postsynaptic potential") + m(MIRBASE:hsa-mir-148a) decreases p(HGNC:NLRP3) - pmid:26813123 + pubmed:30962309 - a(PUBCHEM:1476756) increases bp(GO:memory) + path(EFO:"Endoplasmic Reticulum Stress") decreases m(MIRBASE:hsa-mir-17) - pmid:26813123 + pubmed:30962309 - a(MESH:"Nerve Growth Factor") increases a(MESH:"Cholinergic Neurons") + path(EFO:"Endoplasmic Reticulum Stress") increases p(HGNC:TXNIP) - pmid:26813123 + pubmed:30962309 - a(MESH:"Nerve Growth Factor") increases a(MESH:"Cholinergic Neurons") + path(EFO:arthritis) decreases m(MIRBASE:hsa-mir-20a) - pmid:26813123 + pubmed:30962309 - a(MESH:"Nerve Growth Factor") increases bp(GO:memory) + path(EFO:arthritis) increases p(HGNC:TXNIP) - pmid:11230871 + pubmed:30962309 - a(MESH:"Nerve Growth Factor") increases complex(a(CHEBI:nicotine), p(FPLX:CHRN)) + path(DOID:"alcoholic hepatitis") decreases m(MIRBASE:hsa-mir-148a) - pmid:16273023 + pubmed:30962309 - path(MESH:D000544) association path(MESH:D016874) + path(DOID:"alcoholic hepatitis") increases p(HGNC:TXNIP) - pmid:18986241 + pubmed:30962309 - path(MESH:D000544) increases path(MESH:D016874) + p(HGNC:CXCR4) increases p(HGNC:TXNIP) - pmid:16273023 + pubmed:30962309 - path(MESH:D000544) association path(MESH:D058225) + p(HGNC:CXCR4) increases complex(GO:"NLRP3 inflammasome complex") - pmid:16273023 + pubmed:30988501 - path(MESH:D000544) association bp(GO:"GO:0070997") + p(HGNC:CXCR4) increases bp(GO:"cell migration") - pmid:16273023 + pubmed:30962309 - path(MESH:D000544) decreases bp(MESH:D009435) + m(MIRBASE:hsa-mir-23a) decreases p(HGNC:CXCR4) - pmid:16273023 + pubmed:30962309 - path(MESH:D000544) decreases bp(GO:"GO:0007271") + m(MIRBASE:hsa-mir-23a) decreases act(complex(GO:"NLRP3 inflammasome complex")) - pmid:16273023 + pubmed:30962309 - path(MESH:D000544) decreases bp(GO:"GO:0035249") + m(MIRBASE:hsa-mir-23a) decreases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:16273023 + pubmed:30962309 - path(MESH:D000544) decreases act(p(HGNC:CHAT), ma(cat)) + m(MIRBASE:hsa-mir-23a) increases path(MESH:Neuralgia) - pmid:18986241 + pubmed:30962309 - path(MESH:D000544) decreases p(HGNC:CHAT) + composite(a(CHEBI:"oxidised LDL"), a(MESH:"Endothelial Cells")) decreases m(MIRBASE:hsa-mir-30c-1) - pmid:16273023 + pubmed:30962309 - path(MESH:D000544) decreases bp(GO:"GO:0015871") + composite(a(CHEBI:"oxidised LDL"), a(MESH:"Endothelial Cells")) increases p(HGNC:FOXO3) + + - pmid:16273023 + pubmed:19126755 - path(MESH:D000544) decreases bp(GO:"GO:0008292") + a(MESH:"Endothelial Cells") increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:16273023 + pubmed:28901280 - path(MESH:D000544) causesNoChange p(MESH:D011950) + a(MESH:"Endothelial Cells") increases a(MESH:Acetylcholine) - pmid:16273023 + pubmed:28901280 - path(MESH:D000544) decreases bp(GO:"GO:0051935") + a(MESH:"Endothelial Cells") increases a(MESH:"Choline O-Acetyltransferase") - pmid:16273023 + pubmed:24027553 - path(MESH:D000544) decreases bp(GO:"GO:0014047") + a(MESH:"Endothelial Cells") increases tloc(a(CHEBI:Thrombin), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:16273023 + pubmed:24027553 - path(MESH:D000544) decreases bp(GO:"GO:0014047") + a(MESH:"Endothelial Cells") increases a(CHEBI:Thrombin) - pmid:16273023 + pubmed:30962309 - path(MESH:D000544) decreases bp(MESH:D017774) + m(MIRBASE:hsa-mir-30c-1) decreases p(HGNC:FOXO3) - pmid:16273023 + pubmed:30962309 - path(MESH:D000544) decreases bp(MESH:D017774) + m(MIRBASE:hsa-mir-30c-1) decreases r(HGNC:FOXO3) - pmid:16273023 + pubmed:22179319 - path(MESH:D000544) decreases complex(a(CHEBI:"magnesium(2+)"), p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) + p(HGNC:FOXO3) increases path(MESH:"Cell Survival") + + - pmid:18986241 + pubmed:22179319 - path(MESH:D000544) association path(MESH:D019636) + p(HGNC:FOXO3) increases p(HGNC:BDNF) - pmid:18986241 + pubmed:22179319 - path(MESH:D000544) association path(MESH:D008568) + p(HGNC:FOXO3) increases p(HGNC:PPP1R1B) - pmid:18986241 + pubmed:22179319 - path(MESH:D000544) association path(MESH:D003071) + p(HGNC:FOXO3) decreases p(HGNC:HTT, pmod(CONSO:"CAG repeats")) - pmid:18986241 + pubmed:30116051 - path(MESH:D000544) association path(MESH:D001526) + p(HGNC:FOXO3) increases bp(GO:macroautophagy) - pmid:18986241 + pubmed:30962309 - path(MESH:D000544) association path(HBP:aMCI) + r(HGNC:FOXO3) increases r(HGNC:NLRP3) - pmid:18986241 + pubmed:30962309 - path(MESH:D000544) decreases a(MESH:D059329) + r(HGNC:FOXO3) increases p(HGNC:NLRP3) - pmid:18986241 + pubmed:30962309 - path(MESH:D000544) association a(MESH:D059329) + r(HGNC:FOXO3) increases r(HGNC:CASP1) - pmid:18986241 + pubmed:30962309 - path(MESH:D000544) decreases a(MESH:D059329) + r(HGNC:FOXO3) increases p(HGNC:CASP1) - pmid:18986241 + pubmed:30962309 - path(MESH:D000544) association a(MESH:D016874) + r(HGNC:FOXO3) increases r(HGNC:IL1B) - pmid:18986241 + pubmed:30962309 - path(MESH:D000544) decreases p(HGNC:ACHE) + r(HGNC:FOXO3) increases p(HGNC:IL1B) - pmid:18986241 + pubmed:30962309 - path(MESH:D000544) causesNoChange act(p(HGNC:ACHE)) + path(NCIT:C78739) increases m(MIRBASE:hsa-mir-145) - pmid:18986241 + pubmed:30962309 - path(MESH:D000544) decreases act(p(HGNC:ACHE)) + m(MIRBASE:hsa-mir-145) decreases m(MIRBASE:hsa-mir-145) - pmid:18986241 + pubmed:30962309 - path(MESH:D000544) decreases act(p(HGNC:ACHE)) + m(MIRBASE:hsa-mir-145) increases g(HGNC:TNFRSF9) - pmid:18986241 + pubmed:30962309 - path(MESH:D000544) increases act(p(HGNC:BCHE)) + m(MIRBASE:hsa-mir-145) increases g(HGNC:NFATC1) - pmid:18986241 + pubmed:30962309 - path(MESH:D000544) causesNoChange p(HGNC:SLC18A3) + m(MIRBASE:hsa-mir-145) increases act(complex(GO:"NLRP3 inflammasome complex")) - pmid:18986241 + pubmed:30962309 - path(MESH:D000544) increases path(MESH:D001284) + g(HGNC:TNFRSF9) increases act(complex(GO:"NLRP3 inflammasome complex")) - pmid:18986241 + pubmed:30962309 - path(MESH:D000544) decreases p(HGNC:NTRK1) + g(HGNC:NFATC1) increases act(complex(GO:"NLRP3 inflammasome complex")) - pmid:18986241 + pubmed:30962309 - path(MESH:D000544) increases p(HGNC:NGF) + path(DOID:"rheumatoid arthritis") negativeCorrelation m(MIRBASE:hsa-mir-146a) - pmid:18986241 + pubmed:30962309 - path(MESH:D000544) association p(HGNC:SORT1) + path(DOID:"rheumatoid arthritis") directlyIncreases m(MIRBASE:hsa-mir-146a) - pmid:18986241 + pubmed:30962309 - path(MESH:D000544) decreases bp(GO:"GO:0032455") + path(DOID:"rheumatoid arthritis") directlyDecreases m(MIRBASE:hsa-mir-146a, loc(MESH:"T-Lymphocytes, Regulatory")) - pmid:18986241 + pubmed:30962309 - path(MESH:D000544) increases act(p(HGNC:MMP9)) + path(DOID:"rheumatoid arthritis") negativeCorrelation m(MIRBASE:hsa-mir-155) - pmid:18986241 + pubmed:30962309 - path(MESH:D000544) decreases g(HGNC:NTRK1) + path(DOID:"rheumatoid arthritis") directlyIncreases m(MIRBASE:hsa-mir-155) - pmid:18986241 + pubmed:30962309 - path(MESH:D000544) decreases g(HGNC:NTRK2) + path(DOID:"rheumatoid arthritis") negativeCorrelation m(MIRBASE:hsa-mir-223) - pmid:18986241 + pubmed:30962309 - path(MESH:D000544) decreases g(HGNC:NTRK3) + path(DOID:"rheumatoid arthritis") directlyIncreases m(MIRBASE:hsa-mir-223) - pmid:18986241 + pubmed:30962309 - path(MESH:D000544) increases g(HGNC:NGFR) + path(DOID:"rheumatoid arthritis") directlyIncreases m(MIRBASE:hsa-mir-223, loc(MESH:T-Lymphocytes)) - pmid:18986241 + pubmed:30962309 - path(MESH:D000544) causesNoChange r(HGNC:CHAT) + path(DOID:"rheumatoid arthritis") directlyDecreases m(MIRBASE:hsa-mir-22) - pmid:18986241 + pubmed:30962309 - path(MESH:D000544) increases r(HGNC:CHRNA7) + path(DOID:"rheumatoid arthritis") directlyDecreases m(MIRBASE:hsa-mir-9-1, loc(MESH:Plasma)) - pmid:18986241 + pubmed:30962309 - path(MESH:D000544) increases r(HGNC:CHRNA7) + path(DOID:"relapsing-remitting multiple sclerosis") directlyIncreases m(MIRBASE:hsa-mir-146a) - pmid:18986241 + pubmed:30962309 - path(MESH:D000544) causesNoChange r(HGNC:CHRM1) + path(DOID:"relapsing-remitting multiple sclerosis") directlyIncreases m(MIRBASE:hsa-mir-9-1, loc(MESH:"Leukocytes, Mononuclear")) - pmid:18986241 + pubmed:30962309 - path(MESH:D000544) decreases r(HGNC:SYP) + path(DOID:"relapsing-remitting multiple sclerosis") decreases m(MIRBASE:hsa-mir-214) - pmid:18986241 + pubmed:30962309 - path(MESH:D000544) causesNoChange r(HGNC:VAMP1) + path(DOID:"relapsing-remitting multiple sclerosis") increases m(MIRBASE:hsa-mir-17) - pmid:18986241 + pubmed:27889190 - path(MESH:D000544) causesNoChange r(HGNC:SNAP29) + path(DOID:"relapsing-remitting multiple sclerosis") increases path(DOID:"secondary progressive multiple sclerosis") - pmid:18986241 + pubmed:27889190 - path(MESH:D000544) causesNoChange r(HGNC:APP) + path(DOID:"relapsing-remitting multiple sclerosis") association path(DOID:"optic neuritis") - pmid:18986241 + pubmed:26445701 - path(MESH:D000544) causesNoChange r(HGNC:NOTCH1) + path(DOID:"relapsing-remitting multiple sclerosis") increases path(DOID:"optic neuritis") - pmid:18986241 + pubmed:30988501 - path(MESH:D000544) increases r(HGNC:CTSD) + path(DOID:"relapsing-remitting multiple sclerosis") increases path(DOID:"optic neuritis") - pmid:18986241 + pubmed:27889190 - path(MESH:D000544) decreases r(HGNC:PPP1CA) + path(DOID:"relapsing-remitting multiple sclerosis") association path(DOID:"internuclear ophthalmoplegia") - pmid:18986241 + pubmed:27889190 - path(MESH:D000544) decreases r(HGNC:PPP1CC) + path(DOID:"relapsing-remitting multiple sclerosis") association path(DOID:"trigeminal neuralgia") - pmid:18986241 + pubmed:27889190 - path(MESH:D000544) causesNoChange r(HGNC:MAPT) + path(DOID:"relapsing-remitting multiple sclerosis") association path(DOID:"cerebellar ataxia") - pmid:18986241 + pubmed:27889190 - path(MESH:D000544) decreases a(HBP:"3R tau") + path(DOID:"relapsing-remitting multiple sclerosis") association path(DOID:"pathologic nystagmus") - pmid:16273023 + pubmed:27889190 - path(MESH:D016874) association path(MESH:D000544) + path(DOID:"relapsing-remitting multiple sclerosis") association path(HP:Myelopathy) - pmid:18986241 + pubmed:27889190 - path(MESH:D016874) association bp(HBP:hyperphosphorylation) + path(DOID:"relapsing-remitting multiple sclerosis") association path(HP:"Lhermitte's sign") - pmid:16273023 + pubmed:27889190 - path(MESH:D058225) association path(MESH:D000544) + path(DOID:"relapsing-remitting multiple sclerosis") association path(HP:"Asymmetric limb muscle stiffness") - pmid:18986241 + pubmed:27889190 - path(MESH:D058225) association p(HGNC:BCHE) + path(DOID:"relapsing-remitting multiple sclerosis") association path(MESH:"Erectile Dysfunction") - pmid:18986241 + pubmed:27889190 - path(MESH:D058225) association p(HGNC:ACHE) + path(DOID:"relapsing-remitting multiple sclerosis") positiveCorrelation path(MESH:"Demyelinating Diseases") - pmid:16273023 + pubmed:26445701 - bp(GO:"GO:0070997") association path(MESH:D000544) + path(DOID:"relapsing-remitting multiple sclerosis") increases path(DOID:myelitis) - pmid:16273023 + pubmed:26445701 - bp(GO:"GO:0070997") association act(p(MESH:D017470)) + path(DOID:"relapsing-remitting multiple sclerosis") increases path(HP:"Atrophy/Degeneration affecting the brainstem") - pmid:16273023 + pubmed:27889190 - bp(GO:"GO:0007271") association path(MESH:D003071) + path(DOID:"relapsing-remitting multiple sclerosis") association complex(a(DRUGBANK:Fingolimod), p(HGNCGENEFAMILY:"Sphingosine 1-phosphate receptors")) - pmid:16273023 + pubmed:30988501 - bp(GO:"GO:0007271") association path(MESH:D003071) + path(DOID:"relapsing-remitting multiple sclerosis") increases path(HP:Hemiparesis) - pmid:16273023 + pubmed:30988501 - bp(GO:"GO:0007271") association a(MESH:D002800) + path(DOID:"relapsing-remitting multiple sclerosis") decreases bp(GO:cognition) - pmid:16273023 + pubmed:30988501 - bp(GO:"GO:0035249") association path(MESH:D003071) + path(DOID:"relapsing-remitting multiple sclerosis") increases path(DOID:"mental depression") - pmid:16273023 + pubmed:30962309 - bp(GO:"GO:0035249") association path(MESH:D003071) + path(DOID:"primary progressive multiple sclerosis") directlyDecreases m(MIRBASE:hsa-mir-23a) - pmid:16273023 + pubmed:30962309 - bp(GO:"GO:0035249") increases bp(GO:"GO:0051935") + path(DOID:"primary progressive multiple sclerosis") directlyDecreases m(MIRBASE:hsa-mir-223) - pmid:16273023 + pubmed:27889190 - bp(GO:"GO:0035249") association a(CHEBI:"NMDA receptor antagonist") + path(DOID:"primary progressive multiple sclerosis") increases path(HP:Paraparesis) - pmid:16273023 + pubmed:27889190 - path(MESH:D003071) association bp(GO:"GO:0035249") + path(DOID:"primary progressive multiple sclerosis") increases path(HP:Hemiparesis) - pmid:16273023 + pubmed:27889190 - path(MESH:D003071) association bp(GO:"GO:0035249") + path(DOID:"primary progressive multiple sclerosis") increases path(HP:Hemiparesis) - pmid:16273023 + pubmed:27889190 - path(MESH:D003071) association bp(GO:"GO:0007271") + path(DOID:"primary progressive multiple sclerosis") increases path(DOID:"cerebellar ataxia") - pmid:16273023 + pubmed:27889190 - path(MESH:D003071) association bp(GO:"GO:0007271") + path(DOID:"primary progressive multiple sclerosis") increases path(DOID:dementia) - pmid:18986241 + pubmed:27889190 - path(MESH:D003071) association path(MESH:D000544) + path(DOID:"primary progressive multiple sclerosis") decreases path(MESH:"Visual Perception") - pmid:18986241 + pubmed:27889190 - path(MESH:D003071) association p(HGNC:BCHE) + path(DOID:"primary progressive multiple sclerosis") increases path(HP:"Abnormality of the cerebrospinal fluid") - pmid:18986241 + pubmed:27956442 - path(MESH:D003071) association g(HGNC:NTRK1) + path(DOID:"primary progressive multiple sclerosis") directlyIncreases path(MESH:"Spinal Cord Diseases") - pmid:18986241 + pubmed:27889190 - path(MESH:D003071) association g(HGNC:NTRK2) + path(DOID:"primary progressive multiple sclerosis") increases path(NCIT:C21007) - pmid:18986241 + pubmed:27889190 - path(MESH:D003071) association g(HGNC:NTRK3) + path(DOID:"primary progressive multiple sclerosis") increases path(MESH:"Motor Disorders") - pmid:18986241 + pubmed:27889190 - path(MESH:D003071) negativeCorrelation r(HGNC:CHRNA7) + path(DOID:"primary progressive multiple sclerosis") increases path(HP:Myelopathy) - pmid:18986241 + pubmed:27889190 - path(MESH:D003071) association act(p(HGNC:GAL)) + path(DOID:"primary progressive multiple sclerosis") increases path(HP:Ataxia) - pmid:16273023 + pubmed:27889190 - bp(GO:"GO:0008292") negativeCorrelation path(MESH:D003704) + path(DOID:"primary progressive multiple sclerosis") increases path(MESH:"Vision Disorders") - pmid:16273023 + pubmed:27889190 - path(MESH:D003704) negativeCorrelation bp(GO:"GO:0008292") + path(DOID:"primary progressive multiple sclerosis") decreases path(GO:cognition) - pmid:18986241 + pubmed:30962309 - path(MESH:D003704) association path(HBP:aMCI) + a(PUBCHEM:135314782) decreases path(DOID:"relapsing-remitting multiple sclerosis") - pmid:18986241 + pubmed:30962309 - path(MESH:D003704) association a(MESH:D059329) + a(PUBCHEM:135314782) decreases m(MIRBASE:hsa-mir-17) - pmid:18986241 + pubmed:30962309 - path(MESH:D003704) decreases p(HGNC:ACHE) + a(PUBCHEM:135314782) directlyIncreases m(MIRBASE:hsa-mir-7-1) - pmid:16273023 + pubmed:30962309 - path(MESH:D013850) association a(MESH:D006624) + a(PUBCHEM:135314782) directlyIncreases m(MIRBASE:hsa-mir-20b) - pmid:16273023 + pubmed:28843454 - path(MESH:D013850) association a(MESH:D019579) + a(PUBCHEM:135314782) decreases path(ORPHANET:477738) - pmid:16273023 + pubmed:28843454 - path(MESH:D013850) association a(CHEBI:"glutamate(1-)") + a(PUBCHEM:135314782) isA path(MESH:"Home Infusion Therapy") - pmid:16273023 + pubmed:27794524 - a(MESH:D006624) association path(MESH:D013850) + a(PUBCHEM:135314782) causesNoChange path(MESH:"Developmental Disabilities") - pmid:16273023 + pubmed:27956442 - a(MESH:D006624) association path(MESH:D008568) + a(PUBCHEM:135314782) directlyDecreases p(HGNC:ITGA4) - pmid:16273023 + pubmed:27956442 - a(MESH:D019579) association path(MESH:D013850) + a(PUBCHEM:135314782) directlyIncreases path(MESH:"JC Virus") - pmid:16273023 + pubmed:27956442 - a(MESH:D019579) association path(MESH:D008568) + a(PUBCHEM:135314782) increases path(MESH:Headache) - pmid:16273023 + pubmed:27956442 - path(MESH:D008568) association a(MESH:D006624) + a(PUBCHEM:135314782) increases path(MESH:Dizziness) - pmid:16273023 + pubmed:27956442 - path(MESH:D008568) association a(MESH:D019579) + a(PUBCHEM:135314782) increases path(MESH:Exanthema) - pmid:16273023 + pubmed:27956442 - path(MESH:D008568) association a(CHEBI:"glutamate(1-)") + a(PUBCHEM:135314782) increases path(MESH:Infection) - pmid:16273023 + pubmed:30962309 - path(MESH:D008568) association bp(MESH:D017774) + path(DOID:osteoarthritis) decreases m(MIRBASE:hsa-mir-22) - pmid:18986241 + pubmed:30962309 - path(MESH:D008568) association path(MESH:D000544) + path(DOID:osteoarthritis) causesNoChange m(MIRBASE:hsa-mir-223) - pmid:18986241 + pubmed:30962309 - path(MESH:D008568) association a(MESH:D059329) + path(DOID:osteoarthritis) causesNoChange m(MIRBASE:hsa-mir-155) - pmid:16273023 + pubmed:30962309 - act(p(HGNC:GLS), ma(cat)) directlyIncreases a(CHEBI:"glutamate(1-)") + path(DOID:osteoarthritis) causesNoChange m(MIRBASE:hsa-mir-146a) - pmid:16273023 + pubmed:30962309 - bp(GO:"GO:0014047") increases bp(GO:"GO:0035249") + a(PUBCHEM:135335742) directlyDecreases path(DOID:"rheumatoid arthritis") - pmid:16273023 + pubmed:30962309 - bp(GO:"GO:0014047") increases bp(MESH:D017774) + a(PUBCHEM:135335742) directlyIncreases m(MIRBASE:hsa-mir-22) - pmid:16273023 + pubmed:30962309 - bp(GO:"GO:0051935") increases a(CHEBI:glutamine) + p(MESH:"Rheumatoid Factor") positiveCorrelation m(MIRBASE:hsa-mir-223) - pmid:16273023 + pubmed:30962309 - a(CHEBI:glutamine) increases bp(GO:"GO:0006868") + path(DOID:arthritis) association m(MIRBASE:hsa-mir-146a, loc(MESH:"T-Lymphocytes, Regulatory")) - pmid:16273023 + pubmed:30962309 - act(p(MESH:D017470)) association bp(GO:"GO:0070997") + a(PUBCHEM:5280453) directlyDecreases m(MIRBASE:hsa-mir-155) - pmid:16273023 + pubmed:30962309 - bp(MESH:D017774) association path(MESH:D008568) + path(DOID:proteinuria) association m(MIRBASE:hsa-mir-155) - pmid:16273023 + pubmed:30962309 - bp(MESH:D017774) association path(MESH:D007858) + bp(GO:"glomerular filtration") association m(MIRBASE:hsa-mir-146a) - pmid:16273023 + pubmed:30962309 - path(MESH:D007858) association bp(MESH:D017774) + a(CHEBI:"mycophenolic acid") decreases path(DOID:"systemic lupus erythematosus") - pmid:16273023 + pubmed:30962309 - a(MESH:D017966) association composite(p(MESH:D011950), p(MESH:D017470)) + a(CHEBI:"mycophenolic acid") increases m(MIRBASE:hsa-mir-146a, loc(MESH:T-Lymphocytes)) - + + + pubmed:30962309 + + g(DBSNP:rs57095329) regulates m(MIRBASE:hsa-mir-146a) + - pmid:16273023 + pubmed:30962309 - composite(p(MESH:D011950), p(MESH:D017470)) association a(MESH:D017966) + g(DBSNP:rs57095329) association path(DOID:"systemic lupus erythematosus") - pmid:16273023 + pubmed:24586483 - a(MESH:D002800) increases bp(GO:"GO:0014047") + g(DBSNP:rs57095329) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:16273023 + pubmed:24586483 - a(MESH:D002800) increases bp(GO:"GO:0014047") + g(DBSNP:rs57095329) negativeCorrelation bp(GO:cognition) - pmid:16273023 + pubmed:24586483 - a(MESH:D002800) increases a(CHEBI:acetylcholine) + g(DBSNP:rs57095329) increases g(HGNC:MIR146A) - pmid:16273023 + pubmed:30962309 - a(MESH:D002800) association bp(GO:"GO:0007271") + g(DBSNP:rs2431697) regulates m(MIRBASE:hsa-mir-146a) - pmid:18986241 + pubmed:30962309 - a(MESH:D002800) decreases path(MESH:D000544) + g(DBSNP:rs2431697) association path(DOID:"systemic lupus erythematosus") - pmid:18986241 + pubmed:30962309 - a(MESH:D002800) decreases a(CHEBI:"amyloid-beta") + path(DOID:"lupus nephritis") directlyIncreases m(MIRBASE:hsa-mir-148a) - pmid:18986241 + pubmed:30962309 - a(MESH:D002800) increases bp(MESH:D000066829) + path(DOID:"Crohn's disease") directlyIncreases m(MIRBASE:hsa-mir-23a) - pmid:18986241 + pubmed:30962309 - a(MESH:D002800) association bp(GO:"GO:0050435") + path(DOID:"Crohn's disease") directlyIncreases m(MIRBASE:hsa-mir-146a, loc(BTO:0000271)) - pmid:18986241 + pubmed:30962309 - a(MESH:D002800) association path(MESH:D007319) + path(DOID:"Crohn's disease") directlyIncreases m(MIRBASE:hsa-mir-146a, loc(BTO:0001709)) - pmid:18986241 + pubmed:30962309 - a(MESH:D002800) association path(MESH:D003967) + path(DOID:"ulcerative colitis") causesNoChange m(MIRBASE:hsa-mir-146a, loc(BTO:0000271)) - pmid:18986241 + pubmed:30962309 - a(MESH:D002800) association path(MESH:D009325) + path(DOID:"ulcerative colitis") directlyIncreases m(MIRBASE:hsa-mir-146a, loc(BTO:0001709)) - pmid:18986241 + pubmed:30962309 - a(MESH:D002800) association path(MESH:D005221) + path(MESH:Neuropathology) directlyDecreases m(MIRBASE:hsa-mir-34c) - pmid:18986241 + pubmed:27889190 - a(MESH:D002800) association path(MESH:D000855) + bp(MESH:Sensation) association path(DOID:"multiple sclerosis") - - - pmid:16273023 + pubmed:27889190 - complex(a(CHEBI:acetylcholine), p(MESH:D011950)) increases a(CHEBI:acetylcholine) + path(MESH:"Mobility Limitation") association path(DOID:"multiple sclerosis") + + + pubmed:27889190 + + bp(MESH:"Postural Balance") association path(DOID:"multiple sclerosis") + + - pmid:16273023 + pubmed:27889190 - a(CHEBI:"magnesium(2+)") decreases complex(a(CHEBI:"calcium(2+)"), p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) + a(NCIT:C28381) association path(DOID:"multiple sclerosis") - + + + pubmed:27889190 + + bp(MESH:"Vision, Ocular") association path(DOID:"multiple sclerosis") + - + + + pubmed:27889190 + + path(DOID:"secondary progressive multiple sclerosis") increases path(NCIT:C21007) + - pmid:12428809 + pubmed:27889190 - bp(GO:"axonal transport") association p(HGNC:MAPT) + path(DOID:"secondary progressive multiple sclerosis") increases path(NCIT:C21007) - pmid:12428809 + pubmed:27889190 - bp(GO:"axonal transport") association p(HGNC:APP) + path(DOID:"secondary progressive multiple sclerosis") increases path(MESH:"Motor Disorders") - pmid:12428809 + pubmed:27889190 - bp(GO:"axonal transport") negativeCorrelation path(MESH:"Alzheimer Disease") + path(DOID:"secondary progressive multiple sclerosis") increases path(HP:Myelopathy) - pmid:22908190 + pubmed:27889190 - bp(GO:"axonal transport") negativeCorrelation path(MESH:"Alzheimer Disease") + path(DOID:"secondary progressive multiple sclerosis") increases path(HP:Hemiparesis) - pmid:12428809 + pubmed:27889190 - bp(GO:"axonal transport") association a(CHEBI:"amyloid-beta") + path(DOID:"secondary progressive multiple sclerosis") increases path(HP:Ataxia) - pmid:12428809 + pubmed:27889190 - bp(GO:"axonal transport") association p(HGNC:GSK3B) + path(DOID:"secondary progressive multiple sclerosis") increases path(MESH:"Vision Disorders") - pmid:21722302 + pubmed:27889190 - bp(GO:"axonal transport") association bp(GO:"motor neuron apoptotic process") + path(DOID:"secondary progressive multiple sclerosis") decreases path(GO:cognition) - pmid:26631930 + pubmed:27889190 - bp(GO:"axonal transport") decreases path(HBP:Neurodegeneration) + path(MESH:"Brain Injuries") prognosticBiomarkerFor path(DOID:"multiple sclerosis") - pmid:21734277 + pubmed:27889190 - bp(GO:"axonal transport") negativeCorrelation p(HBP:"phosphatase-activating domain") + path(MESH:"Brain Injuries") prognosticBiomarkerFor path(DOID:"multiple sclerosis") - + + + pubmed:22372633 + + path(MESH:"Brain Injuries") increases p(HGNC:HDAC6) + + + + pubmed:30988501 + + path(MESH:"Brain Injuries") association a(MESH:"Th2 Cells") + + - pmid:24590577 + pubmed:27889190 - complex(a(CHEBI:acetylcholine), p(FPLX:"G_protein"), p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) increases bp(GO:"synaptic transmission, cholinergic") + path(DOID:"neuromyelitis optica") association complex(complex(GO:"IgG immunoglobulin complex"), p(HGNC:AQP4)) - + + + pubmed:27889190 + + path(DOID:"neuromyelitis optica") increases path(DOID:"optic neuritis") + - pmid:24590577 + pubmed:27889190 - complex(p(HGNC:CHRM1), p(HGNC:GNA11)) increases act(p(FPLX:PLC)) + path(DOID:"neuromyelitis optica") positiveCorrelation path(DOID:"optic neuritis") - pmid:24590577 + pubmed:27889190 - complex(p(HGNC:CHRM1), p(HGNC:GNA11)) increases bp(GO:"calcium ion transport") + path(DOID:"neuromyelitis optica") decreases path(MESH:"Visual Perception") - + + + pubmed:27889190 + + path(DOID:"neuromyelitis optica") increases path(DOID:myelitis) + - pmid:24590577 + pubmed:27889190 - complex(p(HGNC:CHRM3), p(HGNC:GNA11)) increases act(p(FPLX:PLC)) + path(DOID:"neuromyelitis optica") positiveCorrelation path(DOID:myelitis) - pmid:24590577 + pubmed:27889190 - complex(p(HGNC:CHRM3), p(HGNC:GNA11)) increases bp(GO:"calcium ion transport") + path(DOID:"neuromyelitis optica") increases path(HP:"Nausea and vomiting") - + + + pubmed:27889190 + + path(DOID:"neuromyelitis optica") increases path(MESH:Inflammation) + - pmid:24590577 + pubmed:27889190 - complex(p(HGNC:CHRM5), p(HGNC:GNA11)) increases act(p(FPLX:PLC)) + path(DOID:"neuromyelitis optica") increases path(MESH:"Brain Injuries") - pmid:24590577 + pubmed:27889190 - complex(p(HGNC:CHRM5), p(HGNC:GNA11)) increases bp(GO:"calcium ion transport") + path(DOID:"neuromyelitis optica") increases complex(p(HGNC:AQP4), p(MESH:"Immunoglobulin G")) - + + + pubmed:30988501 + + path(DOID:"neuromyelitis optica") isA path(DOID:"autoimmune disease of the nervous system") + - pmid:24590577 + pubmed:27889190 - complex(p(HGNC:CHRM2), p(HGNC:GNAO1)) decreases p(HGNCGENEFAMILY:"Adenylate cyclases") + complex(complex(GO:"IgG immunoglobulin complex"), p(HGNC:AQP4)) association path(DOID:"neuromyelitis optica") + + - pmid:24590577 + pubmed:31413141 - complex(p(HGNC:CHRM2), p(HGNC:GNAO1)) decreases a(CHEBI:"3',5'-cyclic AMP") + complex(GO:"IgG immunoglobulin complex") causesNoChange p(HGNC:TREM2, frag("?"), loc(GO:"extracellular region")) @@ -77351,2886 +78117,2829 @@

Statements

- pmid:24590577 + pubmed:30116051 - complex(p(HGNC:CHRM4), p(HGNC:GNAO1)) decreases p(HGNCGENEFAMILY:"Adenylate cyclases") + act(p(HGNC:AQP4)) increases deg(a(CHEBI:amyloid-beta)) - pmid:24590577 + pubmed:29626319 - complex(p(HGNC:CHRM4), p(HGNC:GNAO1)) decreases a(CHEBI:"3',5'-cyclic AMP") + p(HGNC:AQP4) association deg(a(CHEBI:amyloid-beta)) - pmid:24590577 + pubmed:29626319 - path(MESH:Nociception) association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") + p(HGNC:AQP4) decreases a(CHEBI:amyloid-beta) - pmid:24590577 + pubmed:29626319 - a(MESH:Kidney) association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") + p(HGNC:AQP4) decreases a(CHEBI:amyloid-beta) - pmid:29626319 + pubmed:29626319 - a(MESH:Kidney) increases deg(a(CHEBI:"amyloid-beta")) + p(HGNC:AQP4) increases a(HP:"glymphatic system") - pmid:29626319 + pubmed:29626319 - a(MESH:Kidney) decreases a(CHEBI:"amyloid-beta") + p(HGNC:AQP4) increases a(HP:"glymphatic system") - pmid:29626319 + pubmed:27889190 - a(MESH:Kidney) decreases a(CHEBI:"amyloid-beta") + path(DOID:"optic neuritis") association path(DOID:"relapsing-remitting multiple sclerosis") - pmid:29626319 + pubmed:27889190 - a(MESH:Kidney) decreases a(CHEBI:"amyloid-beta polypeptide 40") + path(DOID:"optic neuritis") isA path(MESH:"Demyelinating Diseases") - pmid:29626319 + pubmed:27889190 - a(MESH:Kidney) causesNoChange a(CHEBI:"amyloid-beta polypeptide 42") + path(DOID:"optic neuritis") isA path(DOID:myelitis) - pmid:24590577 + pubmed:27889190 - a(MESH:Thalamus) association p(HGNC:CHRM1) + path(DOID:"optic neuritis") isA path(MESH:"Brain Stem Infarctions") - pmid:24762290 + pubmed:27889190 - a(MESH:Thalamus) association complex(HBP:"alpha-4 beta-2 nAChR") + path(DOID:"optic neuritis") positiveCorrelation path(DOID:"neuromyelitis optica") - pmid:24762290 + pubmed:27889190 - a(MESH:Thalamus) association complex(HBP:"alpha-4 beta-2 nAChR") + path(DOID:"internuclear ophthalmoplegia") association path(DOID:"relapsing-remitting multiple sclerosis") - pmid:24590577 + pubmed:27889190 - p(MGI:Chrm2) decreases path(MESH:"Nociceptive Pain") + path(DOID:"cerebellar ataxia") association path(DOID:"relapsing-remitting multiple sclerosis") - pmid:24590577 + pubmed:27889190 - a(MESH:Hypothalamus) association p(HGNC:CHRM3) + path(DOID:"pathologic nystagmus") association path(DOID:"relapsing-remitting multiple sclerosis") - pmid:24590577 + pubmed:27889190 - p(MGI:Chrm3) regulates bp(GO:"response to food") + path(HP:Myelopathy) association path(DOID:"relapsing-remitting multiple sclerosis") - pmid:24590577 + pubmed:27889190 - p(MGI:Chrm3) increases bp(GO:"pituitary gland development") + path(HP:"Lhermitte's sign") association path(DOID:"relapsing-remitting multiple sclerosis") - pmid:24590577 + pubmed:27889190 - p(MGI:Chrm3) increases p(MGI:Prl) + path(HP:"Asymmetric limb muscle stiffness") association path(DOID:"relapsing-remitting multiple sclerosis") - pmid:24590577 + pubmed:27889190 - p(MGI:Chrm3) increases p(MGI:Gh) + path(MESH:"Erectile Dysfunction") association path(DOID:"relapsing-remitting multiple sclerosis") - pmid:24590577 + pubmed:27889190 - p(MGI:Chrm3) increases bp(GO:"multicellular organism growth") + path(MESH:"Demyelinating Diseases") positiveCorrelation path(DOID:"relapsing-remitting multiple sclerosis") - pmid:24590577 + pubmed:30988501 - a(CHEBI:benzoxazine) decreases path(MESH:"Parkinson Disease") + path(MESH:"Demyelinating Diseases") increases path(HP:"Axonal loss") - pmid:24590577 + pubmed:27794524 - a(MESH:"Pars Compacta") association p(HGNC:CHRM5) + path(MESH:"Demyelinating Diseases") positiveCorrelation bp(GO:"inflammatory response") - pmid:22020111 + pubmed:27794524 - a(CHEBI:cocaine) decreases act(p(HGNC:SLC7A11)) + path(MESH:"Demyelinating Diseases") positiveCorrelation path(MESH:"Tertiary Lymphoid Structures") - pmid:24590577 + pubmed:27794524 - a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases p(MGI:Bace1) + path(MESH:"Demyelinating Diseases") association bp(GO:"microglial cell activation") - pmid:24590577 + pubmed:27794524 - a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases a(CHEBI:"amyloid-beta") + path(MESH:"Demyelinating Diseases") increases path(MESH:"Neurodegenerative Diseases") - pmid:24590577 + pubmed:27956442 - a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases p(HGNC:MAPT, pmod(Ph)) + path(MESH:"Demyelinating Diseases") negativeCorrelation path(MESH:"Central Nervous System") - pmid:24590577 + pubmed:27956442 - a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases p(HGNC:MAPT, pmod(Ph)) + path(MESH:"Demyelinating Diseases") increases path(MESH:"Multiple Sclerosis, Relapsing-Remitting") - pmid:24590577 + pubmed:27956442 - a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases path(MESH:"Plaque, Amyloid") + path(MESH:"Demyelinating Diseases") association path(MESH:Inflammation) - pmid:24590577 + pubmed:27956442 - a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") increases bp(GO:memory) + path(MESH:"Demyelinating Diseases") increases tloc(a(MESH:Lymphocytes), fromLoc(GO:cytoplasm), toLoc(MESH:Brain)) - pmid:24590577 + pubmed:27889190 - a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") increases bp(GO:learning) + path(DOID:myelitis) positiveCorrelation path(DOID:"neuromyelitis optica") - pmid:24590577 + pubmed:21427723 - a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases a(CHEBI:"amyloid-beta polypeptide 42") + path(DOID:dementia) increases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 280)) - pmid:24401760 + pubmed:22530628 - act(p(MGI:Bace1)) increases a(CHEBI:"amyloid-beta") + path(DOID:dementia) positiveCorrelation a(CHEBI:amyloid-beta) - - - pmid:24590577 + pubmed:26979166 - complex(p(HGNC:BACE1), p(HGNC:CHRM1)) increases deg(p(HGNC:BACE1)) + path(DOID:dementia) positiveCorrelation p(MESH:Cholinesterases) - - - pmid:29686391 + pubmed:26979166 - bp(HBP:neurotoxicity) positiveCorrelation a(HBP:"Tau oligomers") + path(DOID:dementia) positiveCorrelation path(MESH:Smoking) - pmid:24590577 + pubmed:30108137 - bp(GO:"Wnt signaling pathway") decreases bp(HBP:neurotoxicity) + path(DOID:dementia) association r(HGNC:TFEB) - pmid:23454242 + pubmed:27956442 - bp(GO:"Wnt signaling pathway") association p(FPLX:PPP2) + path(MESH:"Visual Perception") association path(MESH:"Multiple Sclerosis") + + + + - pmid:18494933 + pubmed:25478017 - bp(GO:"Wnt signaling pathway") negativeCorrelation act(p(HGNC:GSK3B)) + p(MESH:"Immunoglobulin G") increases complex(p(CONSO:"4R tau", var("p.151_391del")), p(MESH:"Immunoglobulin G")) + + - pmid:24590577 + pubmed:27889190 - a(MESH:cevimeline) increases act(p(HGNC:CHRM1)) + path(CONSO:neuroinflammation) increases a(MESH:"Oligoclonal Bands") - pmid:24027553 + pubmed:24586483 - act(p(HGNCGENEFAMILY:Caspases)) increases deg(p(HGNC:MAPT)) + path(CONSO:neuroinflammation) association m(HGNC:MIR146A) - pmid:24027553 + pubmed:26836182 - act(p(HGNCGENEFAMILY:Caspases)) increases deg(p(HGNC:MAPT)) + path(CONSO:neuroinflammation) positiveCorrelation bp(GO:"microglial cell activation") - pmid:24027553 + pubmed:26836182 - act(p(HGNCGENEFAMILY:Caspases)) increases deg(p(HGNC:MAPT)) + path(CONSO:neuroinflammation) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:24027553 + pubmed:26836182 - act(p(HGNCGENEFAMILY:Caspases)) positiveCorrelation path(MESH:"Neurofibrillary Tangles") + path(CONSO:neuroinflammation) positiveCorrelation p(HGNC:CHI3L1) - pmid:24027553 + pubmed:26836182 - act(p(HGNCGENEFAMILY:Caspases)) association path(MESH:"Neurofibrillary Tangles") + path(CONSO:neuroinflammation) positiveCorrelation p(HGNC:CCL2) - pmid:24027553 + pubmed:27716675 - act(p(HGNCGENEFAMILY:Caspases)) increases a(HBP:"Tau aggregates") + path(CONSO:neuroinflammation) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) - pmid:24027553 + pubmed:27716675 - act(p(HGNCGENEFAMILY:Caspases)) increases p(HGNC:MAPT, frag("?")) + path(CONSO:neuroinflammation) positiveCorrelation a(CONSO:"Tau oligomers") - pmid:24590577 + pubmed:27314526 - a(MESH:"1-((4-cyano-4-(pyridine-2-yl)piperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid") increases act(p(MGI:Chrm1)) + path(CONSO:neuroinflammation) association tloc(a(MESH:Interleukins), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:24590577 + pubmed:30988501 - a(MESH:"1-((4-cyano-4-(pyridine-2-yl)piperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid") increases bp(GO:memory) + path(CONSO:neuroinflammation) decreases bp(GO:cognition) - pmid:24590577 + pubmed:30988501 - a(MESH:"1-((4-cyano-4-(pyridine-2-yl)piperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid") increases path(MESH:"Executive Function") + path(CONSO:neuroinflammation) decreases act(a(MESH:Neurons)) - - - - - pmid:24590577 + pubmed:27889190 - complex(p(FPLX:"G_protein"), p(HGNC:CHRM1)) increases a(HBP:"sAPP-alpha") + path(MESH:"Spinal Cord Injuries") positiveCorrelation path(DOID:"multiple sclerosis") - pmid:24590577 + pubmed:27889190 - complex(p(FPLX:"G_protein"), p(HGNC:CHRM1)) decreases a(CHEBI:"amyloid-beta") + path(MESH:"Spinal Cord Injuries") prognosticBiomarkerFor path(DOID:"multiple sclerosis") - pmid:24590577 + pubmed:24561250 - complex(p(FPLX:"G_protein"), p(HGNC:CHRM1)) increases bp(GO:"signal transduction") + path(MESH:"Spinal Cord Injuries") increases act(complex(GO:"NLRP1 inflammasome complex")) - pmid:24590577 + pubmed:24561250 - a(CHEBI:cevimeline) decreases a(CHEBI:"amyloid-beta polypeptide 42") + path(MESH:"Spinal Cord Injuries") increases act(complex(GO:"NLRP1 inflammasome complex")) - pmid:24590577 + pubmed:24561250 - a(CHEBI:cevimeline) decreases path(MESH:"Sjogren's Syndrome") + path(MESH:"Spinal Cord Injuries") increases tloc(p(HGNC:IL18), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:24590577 + pubmed:24561250 - a(CHEBI:cevimeline) decreases a(CHEBI:"amyloid-beta") + path(MESH:"Spinal Cord Injuries") increases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:24590577 + pubmed:24561250 - a(CHEBI:cevimeline) causesNoChange a(HBP:"sAPP-alpha") + path(MESH:"Spinal Cord Injuries") increases a(CHEBI:ATP) - pmid:24590577 + pubmed:26445701 - a(CHEBI:cevimeline) increases path(MESH:Confusion) + path(HP:"CNS demyelination") biomarkerFor path(DOID:"multiple sclerosis") - pmid:24590577 + pubmed:26445701 - a(CHEBI:cevimeline) increases path(MESH:Diarrhea) + path(HP:"CNS demyelination") increases a(HP:"Senile plaques") - pmid:24590577 + pubmed:27889190 - a(CHEBI:cevimeline) increases path(MESH:Asthenia) + path(HP:"CNS demyelination") positiveCorrelation path(MESH:Meningitis) - pmid:24590577 + pubmed:30988501 - a(CHEBI:cevimeline) increases path(MESH:"Gastrointestinal Diseases") + path(HP:"CNS demyelination") increases deg(a(MESH:"White Matter")) - pmid:24590577 + pubmed:30988501 - a(MESH:"talsaclidine fumarate") increases a(HBP:"sAPP-alpha") + path(HP:"CNS demyelination") decreases bp(MESH:Neuroprotection) - pmid:24590577 + pubmed:30988501 - a(MESH:"talsaclidine fumarate") decreases a(CHEBI:"amyloid-beta") + path(HP:"CNS demyelination") decreases bp(GO:"axonal transport") - pmid:24590577 + pubmed:30988501 - a(MESH:"talsaclidine fumarate") increases path(MESH:Sweating) + path(HP:"CNS demyelination") decreases a(GO:"postsynaptic density") - pmid:24590577 + pubmed:27889190 - a(MESH:"talsaclidine fumarate") increases path(MESH:Salivation) + path(MESH:"Optic Atrophy, Hereditary, Leber") increases path(MESH:"Vision, Low") - pmid:24590577 + pubmed:27889190 - a(MESH:"WAY 132983") increases bp(GO:cognition) + path(MESH:"Optic Atrophy, Hereditary, Leber") increases path(MESH:"Wounds and Injuries") - pmid:24590577 + pubmed:27794524 - a(MESH:"WAY 132983") increases path(MESH:Salivation) + path(MESH:"Optic Atrophy, Hereditary, Leber") isA path(MESH:"Mitochondrial Diseases") - pmid:24590577 + pubmed:30515821 - a(MESH:"WAY 132983") increases path(MESH:Hypothermia) + path(MESH:"Wounds and Injuries") association act(p(HGNC:CDK5)) - pmid:24590577 + pubmed:30515821 - a(HBP:VU0029767) increases complex(a(CHEBI:acetylcholine), p(HGNC:CHRM1)) + path(MESH:"Wounds and Injuries") association p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 616)) - - - - - pmid:24590577 + pubmed:30515821 - a(HBP:VU0090157) increases complex(a(CHEBI:acetylcholine), p(HGNC:CHRM1)) + path(MESH:"Wounds and Injuries") negativeCorrelation path(MESH:"Mitochondrial Dynamics") - pmid:24590577 + pubmed:27889190 - a(HBP:VU0184670) increases act(p(HGNC:CHRM1)) + path(DOID:"Behcet's disease") increases path(HP:Myelopathy) - pmid:24590577 + pubmed:27889190 - a(HBP:VU0184670) increases bp(GO:"NMDA selective glutamate receptor signaling pathway") + path(DOID:"Behcet's disease") increases path(MESH:"Oral Ulcer") - pmid:26088141 + pubmed:27889190 - p(HGNC:GNAS) increases complex(p(HGNC:CHRNA7), p(HGNC:GNAS)) + path(DOID:"Behcet's disease") increases path(MESH:Ulcer) - - - - - - - - - - - - - pmid:26088141 + pubmed:27889190 - p(HGNC:GNAI2) increases complex(p(HGNC:CHRNA7), p(HGNC:GNAI2)) + path(DOID:"Behcet's disease") association path(DOID:"multiple sclerosis") - - - - - pmid:26088141 + pubmed:27889190 - p(HGNCGENEFAMILY:"G protein subunits beta") increases complex(p(FPLX:"G_protein"), p(HGNC:CHRNA7)) + path(DOID:"Sjogren's syndrome") increases path(DOID:"optic neuritis") - - - - - - - - - - - pmid:26088141 + pubmed:27889190 - composite(p(HBP:"alpha-Bungarotoxin"), p(HGNC:CHRNA7), p(MESH:"Heterotrimeric GTP-Binding Proteins")) increases complex(a(HBP:"alpha-Bungarotoxin"), p(MESH:"Heterotrimeric GTP-Binding Proteins")) + path(DOID:"Sjogren's syndrome") increases path(DOID:myelitis) - pmid:21958873 + pubmed:27889190 - p(HBP:"alpha-Bungarotoxin") causesNoChange a(CHEBI:"amyloid-beta") + path(DOID:"Sjogren's syndrome") increases path(MESH:"Abortion, Habitual") - pmid:21958873 + pubmed:27889190 - p(HBP:"alpha-Bungarotoxin") decreases act(a(MESH:"Receptors, Nicotinic")) + path(DOID:"antiphospholipid syndrome") increases path(DOID:"optic neuritis") - - - - - pmid:26088141 + pubmed:27889190 - p(HBP:"GPBC, alpha-7 nAChR") orthologous p(HBP:"GPBC, Glycine Receptor 1") + path(DOID:"antiphospholipid syndrome") increases path(DOID:myelitis) - pmid:26088141 + pubmed:27889190 - p(HBP:"GPBC, Glycine Receptor 1") orthologous p(HBP:"GPBC, alpha-7 nAChR") + path(DOID:"antiphospholipid syndrome") increases path(MESH:"Abortion, Habitual") - pmid:26088141 + pubmed:27889190 - p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) increases bp(HBP:"nAChR assembly") + path(DOID:"antiphospholipid syndrome") increases path(DOID:thrombosis) - pmid:26088141 + pubmed:27889190 - p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) increases p(HGNC:CHRNA7) + path(DOID:CADASIL) increases path(DOID:migraine) - pmid:26088141 + pubmed:27889190 - p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")), p(HGNC:GNAQ)) + path(DOID:CADASIL) increases path(MESH:"Vascular Diseases") - pmid:26088141 + pubmed:27889190 - p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")), p(HGNC:GNAQ)) + path(DOID:CADASIL) increases path(HP:Hemiparesis) - pmid:26088141 + pubmed:27889190 - p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")), p(HGNC:GNAQ)) + path(DOID:CADASIL) increases path(DOID:dementia) - pmid:26088141 + pubmed:27889190 - p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")), p(HGNC:GNAQ)) + path(MESH:"Susac Syndrome") increases path(HP:Encephalopathy) - pmid:26088141 + pubmed:27889190 - p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(FPLX:"G_beta"), p(FPLX:"G_gamma"), p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) + path(MESH:"Susac Syndrome") decreases path(MESH:"Visual Perception") - pmid:26088141 + pubmed:27889190 - p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(FPLX:"G_beta"), p(FPLX:"G_gamma"), p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) + path(MESH:"Susac Syndrome") increases path(MESH:Deafness) - pmid:26088141 + pubmed:27889190 - p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(FPLX:"G_beta"), p(FPLX:"G_gamma"), p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) + path(DOID:"central nervous system vasculitis") increases path(HP:Headache) - pmid:26088141 + pubmed:27889190 - p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) decreases act(a(CHEBI:choline)) + path(DOID:"central nervous system vasculitis") increases path(HP:Hemiparesis) - pmid:26088141 + pubmed:27889190 - p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) decreases a(CHEBI:"calcium(2+)") + path(DOID:"central nervous system vasculitis") increases path(HP:Ataxia) - pmid:26088141 + pubmed:27889190 - p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) decreases act(a(CHEBI:"calcium(2+)", loc(GO:intracellular))) + path(DOID:"central nervous system vasculitis") decreases bp(GO:cognition) - pmid:26088141 + pubmed:27889190 - p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) decreases bp(GO:"calcium-mediated signaling") + path(DOID:"central nervous system vasculitis") association path(DOID:"multiple sclerosis") - pmid:26088141 + pubmed:27889190 - p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) decreases bp(MESH:"Pleckstrin Homology Domains") + path(DOID:neurosarcoidosis) increases path(HP:"Optic neuropathy") - pmid:26088141 + pubmed:27889190 - g(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) causesNoChange p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) + path(DOID:neurosarcoidosis) increases path(HP:Myelopathy) - - - - - - - - - - - - - - - - - - - - - pmid:26088141 + pubmed:27889190 - composite(a(CHEBI:choline), p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)") + path(DOID:neurosarcoidosis) increases path(HP:"Facial palsy") - pmid:26088141 + pubmed:27889190 - composite(a(CHEBI:choline), p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)") + path(DOID:neurosarcoidosis) association path(DOID:"multiple sclerosis") - - - - - pmid:26088141 + pubmed:23383175 - composite(a(CHEBI:choline), p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) decreases a(CHEBI:"calcium(2+)") + path(MESH:"Neurologic Manifestations") association p(MGI:Stat3, pmod(go:0006468 ! "protein phosphorylation")) - pmid:26088141 + pubmed:27889190 - composite(a(CHEBI:choline), p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) decreases a(CHEBI:"calcium(2+)") + path(MESH:"Central Nervous System Diseases") association path(DOID:"multiple sclerosis") - pmid:26088141 + pubmed:27889190 - a(MESH:"GP Antagonist-2A peptide") causesNoChange a(CHEBI:"calcium(2+)") + path(DOID:"leukoencephalopathy with vanishing white matter") association path(DOID:"multiple sclerosis") - pmid:26088141 + pubmed:27889190 - a(MESH:"GP Antagonist-2A peptide") causesNoChange act(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) + path(MESH:"Vasculopathy, Retinal, With Cerebral Leukodystrophy") association path(DOID:"multiple sclerosis") - pmid:26088141 + pubmed:27889190 - a(MESH:"GP Antagonist-2A peptide") decreases bp(MESH:"Pleckstrin Homology Domains") + path(MESH:"Brain Diseases, Metabolic") association path(DOID:"multiple sclerosis") - pmid:26088141 + pubmed:27889190 - a(MESH:Barium) causesNoChange bp(GO:"calcium-mediated signaling") + path(DOID:"acute disseminated encephalomyelitis") increases path(HP:"CNS demyelination") - pmid:26088141 + pubmed:27889190 - a(MESH:Barium) causesNoChange act(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) + path(DOID:"acute disseminated encephalomyelitis") increases path(MESH:Leukocytosis) - pmid:26088141 + pubmed:27889190 - a(MESH:Barium) causesNoChange act(p(HGNC:CHRNA7)) + path(DOID:"acute disseminated encephalomyelitis") increases p(MESH:Proteins) - pmid:26088141 + pubmed:27889190 - a(CHEBI:nifedipine) decreases act(a(CHEBI:choline)) + path(DOID:"acute disseminated encephalomyelitis") increases path(HP:Encephalopathy) - pmid:26088141 + pubmed:27889190 - a(CHEBI:nifedipine) decreases a(CHEBI:"calcium(2+)") + path(DOID:"acute disseminated encephalomyelitis") association path(MESH:Consciousness) - pmid:26088141 + pubmed:27889190 - a(CHEBI:nifedipine) increases bp(GO:"calcium-mediated signaling") + path(DOID:"acute disseminated encephalomyelitis") association bp(GO:behavior) - pmid:26088141 + pubmed:27889190 - a(CHEBI:nifedipine) causesNoChange bp(GO:"calcium-mediated signaling") + path(DOID:"acute disseminated encephalomyelitis") association bp(GO:cognition) - pmid:26088141 + pubmed:27889190 - a(CHEBI:nifedipine) causesNoChange act(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) + path(MESH:Consciousness) association path(DOID:"acute disseminated encephalomyelitis") - pmid:26088141 + pubmed:28843454 - bp(MESH:"Pleckstrin Homology Domains") association a(CHEBI:choline) + path(MESH:"Life Style") association path(DOID:"multiple sclerosis") - pmid:26088141 + pubmed:28843454 - a(MESH:"xestospongin C") decreases act(p(HGNC:CHRNA7)) + path(MESH:Environment) association path(DOID:"multiple sclerosis") - pmid:26088141 + pubmed:28843454 - a(MESH:"xestospongin C") decreases bp(GO:"calcium-mediated signaling") + path(NCIT:C68642) positiveCorrelation path(DOID:"multiple sclerosis") - pmid:26088141 + pubmed:28843454 - a(MESH:"xestospongin C") decreases act(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) + path(MESH:Sunlight) association path(DOID:"multiple sclerosis") - - - - - pmid:25514383 + pubmed:28843454 - a(MESH:"White Matter") negativeCorrelation path(MESH:"Alzheimer Disease") + path(MESH:Sunlight) decreases path(MESH:Mortality) - pmid:26195256 + pubmed:28843454 - a(MESH:"White Matter") association path(MESH:"Alzheimer Disease") + bp(GO:"response to light intensity") association path(DOID:"multiple sclerosis") - pmid:24762290 + pubmed:28843454 - a(MESH:"White Matter") positiveCorrelation complex(HBP:"alpha-4 beta-2 nAChR") + path(MESH:Work) decreases path(MESH:Mortality) - pmid:30012004 + pubmed:28843454 - a(MESH:"White Matter") negativeCorrelation path(MESH:"Huntington Disease") + a(MESH:"Ultraviolet Rays") decreases path(EFO:"experimental autoimmune encephalomyelitis") - pmid:25514383 + pubmed:28843454 - a(HP:"cholinergic neuron") negativeCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:"24,25-Dihydroxyvitamin D") decreases path(DOID:"multiple sclerosis") - pmid:25514383 + pubmed:28843454 - a(HP:"cholinergic neuron") association bp(GO:cognition) + a(CHEBI:"24,25-Dihydroxyvitamin D") association path(DOID:"multiple sclerosis") - pmid:25514383 + pubmed:28843454 - a(HP:"cholinergic neuron") increases bp(GO:cognition) + a(CHEBI:"24,25-Dihydroxyvitamin D") decreases path(DOID:"multiple sclerosis") - pmid:25514383 + pubmed:28843454 - a(HP:"cholinergic neuron") association path(MESH:Attention) + a(MESH:"Vitamin D") negativeCorrelation path(ORPHANET:477738) - - - - - - - - - - - - - - - - - - - - - - - - - pmid:25514383 + pubmed:28843454 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"calcium ion transport") + a(MESH:"Vitamin D") negativeCorrelation path(DOID:"multiple sclerosis") - pmid:25514383 + pubmed:28843454 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") positiveCorrelation bp(GO:"calcium ion transport") + a(MESH:"Vitamin D") regulates path(MESH:"Gastrointestinal Microbiome") - pmid:28445721 + pubmed:28843454 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"calcium ion transport") + path(ORPHANET:477738) negativeCorrelation a(MESH:"Vitamin D") - pmid:21482353 + pubmed:28843454 - act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) association bp(GO:"calcium ion transport") + path(ORPHANET:477738) directlyIncreases path(MESH:"Epstein-Barr Virus Infections") - pmid:25514383 + pubmed:28843454 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") regulates tloc(a(CHEBI:neurotransmitter), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) + path(ORPHANET:477738) regulates path(MESH:"Gastrointestinal Microbiome") - pmid:25514383 + pubmed:28843454 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") regulates bp(GO:"second-messenger-mediated signaling") + path(ORPHANET:477738) increases composite(p(EFO:"Anti-Epstein-Barr virus early antigen IgG measurement"), p(NCIT:C52341)) - pmid:25514383 + pubmed:28843454 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") regulates bp(GO:"neuron cellular homeostasis") + path(ORPHANET:477738) association path(EFO:"developmental disability") - pmid:25514383 + pubmed:28843454 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") regulates bp(GO:"gene expression") + path(ORPHANET:477738) association path(DOID:"mental depression") - pmid:25514383 + pubmed:28843454 - act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases a(GO:"glutamatergic synapse") + path(ORPHANET:477738) association path(MESH:Fatigue) - pmid:25514383 + pubmed:28843454 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + path(ORPHANET:477738) decreases path(MESH:Exercise) - pmid:25514383 + pubmed:28843454 - act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) regulates tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + path(ORPHANET:477738) association path(DOID:"cognitive disorder") - pmid:25514383 + pubmed:27794524 - act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases bp(GO:"positive regulation of synaptic plasticity") + path(MESH:"Epstein-Barr Virus Infections") association p(NCBIGENE:7707, loc(MESH:"Plasma Cells")) - pmid:25514383 + pubmed:27794524 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"positive regulation of synaptic plasticity") + path(MESH:"Epstein-Barr Virus Infections") directlyIncreases bp(GO:"CD8-positive, alpha-beta T cell differentiation involved in immune response") - pmid:25514383 + pubmed:27956442 - act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases bp(GO:"intracellular signal transduction") + path(MESH:"Epstein-Barr Virus Infections") positiveCorrelation path(MESH:"Multiple Sclerosis") - pmid:25514383 + pubmed:26445701 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases p(FPLX:AKT, pmod(Ph)) + path(MESH:"Epstein-Barr Virus Infections") positiveCorrelation path(DOID:"multiple sclerosis") - pmid:25514383 + pubmed:28843454 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"ERK1 and ERK2 cascade") + p(NCIT:C52341) regulates bp(MESH:"Antibody Formation") + + - pmid:25514383 + pubmed:30988501 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") decreases bp(HP:Neurodegeneration) + bp(MESH:"Antibody Formation") increases bp(MESH:"Adaptive Immunity") - pmid:25514383 + pubmed:30988501 - act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases bp(HP:Neurodegeneration) + bp(MESH:"Antibody Formation") association bp(GO:"embryonic brain development") - pmid:25514383 + pubmed:28843454 - act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases bp(MESH:"Cell Survival") + path(EFO:"cytomegalovirus infection") increases path(EFO:"Anti-cytomegalovirus IgG measurement") - pmid:25514383 + pubmed:28843454 - act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases a(GO:synapse) + path(EFO:"cytomegalovirus infection") decreases path(ORPHANET:477738) - pmid:25514383 + pubmed:28843454 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases act(a(CHEBI:"pregnenolone sulfate")) + path(EFO:"Anti-cytomegalovirus IgG measurement") decreases path(ORPHANET:477738) - pmid:25514383 + pubmed:28843454 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:cognition) + path(EFO:"human herpesvirus 6 seropositivity") association path(DOID:"multiple sclerosis") - pmid:25514383 + pubmed:30988501 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"synaptic transmission, glutamatergic") + act(p(MESH:Antibodies)) increases bp(MESH:"Adaptive Immunity") - pmid:25514383 + pubmed:28843454 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases act(a(CHEBI:simvastatin)) + path(MESH:Smoking) increases path(DOID:"multiple sclerosis") - pmid:25514383 + pubmed:26445701 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:memory) + path(MESH:Smoking) increases path(DOID:"multiple sclerosis") - pmid:25514383 + pubmed:28843454 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") decreases bp(GO:"apoptotic process") + path(MESH:Smoking) increases path(EFO:"developmental disability") - pmid:28445721 + pubmed:27956442 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") association bp(MESH:"Physiological Phenomena") + path(MESH:Smoking) positiveCorrelation path(MESH:"Multiple Sclerosis") - pmid:28445721 + pubmed:29196815 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") association path(MESH:Disease) + path(MESH:Smoking) increases path(MESH:"Alzheimer Disease") - pmid:21482353 + pubmed:29428175 - act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases act(p(MGI:Lynx1)) + path(MESH:Smoking) positiveCorrelation g(HGNC:RHOA, var("?")) - pmid:21482353 + pubmed:26979166 - act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) association bp(GO:"generation of neurons") + path(MESH:Smoking) association path(DOID:schizophrenia) - pmid:21482353 + pubmed:26979166 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") regulates bp(GO:"sensory processing") + path(MESH:Smoking) positiveCorrelation path(MESH:Depression) - pmid:21482353 + pubmed:26979166 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"sensory processing") + path(MESH:Smoking) positiveCorrelation path(DOID:"bipolar disorder") - pmid:21482353 + pubmed:26979166 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") association a(HP:"inhibitory interneuron") + path(MESH:Smoking) negativeCorrelation path(DOID:"Parkinson's disease") - pmid:21482353 + pubmed:26979166 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases a(HP:"inhibitory interneuron") + path(MESH:Smoking) negativeCorrelation path(DOID:"Parkinson's disease") - pmid:21482353 + pubmed:26979166 - a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") association path(MESH:Schizophrenia) + path(MESH:Smoking) negativeCorrelation path(DOID:"Parkinson's disease") - pmid:28132910 + pubmed:26979166 - act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) negativeCorrelation a(HBP:"B-973") + path(MESH:Smoking) positiveCorrelation path(DOID:dementia) - pmid:30664622 + pubmed:26979166 - a(GO:"glutamatergic synapse") association act(a(PUBCHEM:9832404)) + path(MESH:Smoking) positiveCorrelation path(DOID:"Alzheimer's disease") - pmid:30664622 + pubmed:26979166 - a(GO:"glutamatergic synapse") association act(p(HGNC:ADNP)) + path(MESH:Smoking) positiveCorrelation path(DOID:"Alzheimer's disease") - pmid:25514383 + pubmed:21482353 - a(HBP:"alpha-7 beta-2 nAChR") negativeCorrelation act(a(CHEBI:"amyloid-beta")) + path(MESH:Smoking) decreases path(MESH:"Parkinson Disease") - - - - - pmid:25514383 + pubmed:22807490 - complex(a(CHEBI:"amyloid-beta"), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) decreases bp(HP:Neurodegeneration) + path(MESH:Smoking) association path(MESH:"Hashimoto Disease") - pmid:25514383 + pubmed:22807490 - complex(a(CHEBI:"amyloid-beta"), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) decreases a(HBP:"amyloid-beta aggregates") + path(MESH:Smoking) association path(MESH:"Colitis, Ulcerative") - pmid:25514383 + pubmed:22807490 - p(HGNC:APP, frag("12_28")) increases complex(p(HGNC:APP, frag("12_28")), p(HGNC:CHRNA7)) + path(MESH:Smoking) negativeCorrelation p(HGNC:TPO) - - - - - - - - - - - - - - - - - - - - - - - - - - - - - pmid:25514383 + pubmed:28391535 - complex(a(CHEBI:"amyloid-beta"), p(FPLX:CHRN)) increases bp(GO:"intracellular signal transduction") + path(MESH:Smoking) increases a(MESH:"Blood Glucose") - pmid:25514383 + pubmed:28843454 - complex(a(CHEBI:"amyloid-beta"), p(FPLX:CHRN)) decreases bp(MESH:"Cell Survival") + a(MESH:"Tobacco, Smokeless") causesNoChange path(DOID:"multiple sclerosis") - pmid:25514383 + pubmed:28843454 - complex(a(CHEBI:"amyloid-beta"), p(FPLX:CHRN)) association bp(GO:"neuron cellular homeostasis") + a(CHEBI:nicotine) causesNoChange path(DOID:"multiple sclerosis") - pmid:27522251 + pubmed:26979166 - complex(a(CHEBI:"amyloid-beta"), p(FPLX:CHRN)) increases path(MESH:"Memory Disorders") + a(CHEBI:nicotine) decreases path(DOID:"multiple sclerosis") - - - - - + + + pubmed:19126755 + + a(CHEBI:nicotine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + - pmid:25514383 + pubmed:19126755 - a(PUBCHEM:637026) increases act(a(HBP:"beta-2-containing nAChR")) + a(CHEBI:nicotine) decreases deg(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits", loc(GO:"endoplasmic reticulum"))) - pmid:25514383 + pubmed:19126755 - a(HBP:"amyloid-beta 40 oligomers") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + a(CHEBI:nicotine) increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - + + + pubmed:19126755 + + a(CHEBI:nicotine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + - pmid:25514383 + pubmed:19126755 - composite(a(CHEBI:"amyloid-beta"), a(CHEBI:nicotine)) increases act(a(HBP:"alpha-4 beta-2 nAChR")) + a(CHEBI:nicotine) causesNoChange p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:28420982 + pubmed:19126755 - bp(GO:"intracellular signal transduction") association p(HGNC:MAPT) + a(CHEBI:nicotine) regulates p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:25514383 + pubmed:19126755 - a(HBP:"amyloid-beta 42 oligomers") increases bp(GO:"long-term synaptic potentiation") + a(CHEBI:nicotine) regulates act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:22419736 + pubmed:19293145 - a(HBP:"amyloid-beta 42 oligomers") association path(MESH:Tauopathies) + a(CHEBI:nicotine) association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:22419736 + pubmed:19293145 - a(HBP:"amyloid-beta 42 oligomers") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + a(CHEBI:nicotine) increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:28901280 + pubmed:22530628 - bp(MESH:"Cell Survival") association a(MESH:Acetylcholine) + a(CHEBI:nicotine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:30126037 + pubmed:30697142 - bp(MESH:"Cell Survival") association bp(GO:"cellular senescence") + a(CHEBI:nicotine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:24563850 + pubmed:19721446 - bp(HP:Neurodegeneration) association bp(GO:"protein oxidation") + a(CHEBI:nicotine) increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:30126037 + pubmed:19721446 - bp(HP:Neurodegeneration) association p(HGNC:CDKN2A) + act(a(CHEBI:nicotine)) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:28420982 + pubmed:28391535 - bp(HP:Neurodegeneration) decreases sec(p(HGNC:MAPT)) + a(CHEBI:nicotine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:25514383 + pubmed:19126755 - p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Val717Phe")) decreases path(MESH:"Spatial Memory") + a(CHEBI:nicotine) causesNoChange a(MESH:Manduca) - pmid:28173111 + pubmed:19126755 - p(MGI:Syp) negativeCorrelation p(MGI:Dnm1l) + a(CHEBI:nicotine) association path(CONSO:neurotoxicity) - pmid:28173111 + pubmed:19293145 - p(MGI:Syp) association act(complex(GO:"neuron to neuron synapse")) + a(CHEBI:nicotine) decreases path(CONSO:neurotoxicity) - pmid:28901280 + pubmed:19126755 - path(MESH:"Cognition Disorders") association p(MESH:"Receptors, Nicotinic") + a(CHEBI:nicotine) increases p(CONSO:"alpha-4 beta-2 nAChR") - pmid:25514383 + pubmed:19126755 - a(CHEBI:"(-)-cotinine") increases path(MESH:Attention) + a(CHEBI:nicotine) increases p(CONSO:"alpha-4 beta-2 nAChR") - pmid:25514383 + pubmed:19126755 - a(CHEBI:"(-)-cotinine") increases bp(GO:memory) + a(CHEBI:nicotine) increases p(CONSO:"alpha-4 beta-2 nAChR") - pmid:25514383 + pubmed:19126755 - a(CHEBI:"(-)-cotinine") decreases path(MESH:"Plaque, Amyloid") + a(CHEBI:nicotine) decreases act(p(CONSO:"alpha-4 beta-2 nAChR")) - pmid:25514383 + pubmed:19293145 - a(CHEBI:"(-)-cotinine") increases act(p(FPLX:AKT)) + act(a(CHEBI:nicotine)) increases p(CONSO:"alpha-4 beta-2 nAChR") - pmid:25514383 + pubmed:21482353 - a(CHEBI:"(-)-cotinine") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + a(CHEBI:nicotine) increases act(p(CONSO:"alpha-4 beta-2 nAChR")) - pmid:25514383 + pubmed:21482353 - a(HBP:"S 24795") decreases a(CHEBI:"amyloid-beta") + a(CHEBI:nicotine) increases act(p(CONSO:"alpha-4 beta-2 nAChR")) - pmid:25514383 + pubmed:21482353 - a(HBP:"S 24795") increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + a(CHEBI:nicotine) increases act(p(CONSO:"alpha-4 beta-2 nAChR")) - pmid:25514383 + pubmed:21482353 - a(HBP:"4-OH-GTS-21") increases path(MESH:"Spatial Memory") + a(CHEBI:nicotine) increases act(p(CONSO:"alpha-4 beta-2 nAChR")) - pmid:17640819 + pubmed:21482353 - a(HBP:"4-OH-GTS-21") increases path(MESH:"Spatial Memory") + a(CHEBI:nicotine) increases act(p(CONSO:"alpha-4 beta-2 nAChR")) - pmid:25514383 + pubmed:18174175 - a(HBP:"4-OH-GTS-21") causesNoChange bp(GO:"neuron cellular homeostasis") + a(CHEBI:nicotine) increases p(CONSO:"alpha-4 beta-2 nAChR") + + - pmid:17640819 + pubmed:19126755 - a(HBP:"4-OH-GTS-21") increases path(MESH:"Avoidance Learning") + a(CHEBI:nicotine) increases complex(a(CHEBI:nicotine), p(CONSO:"alpha-4 beta-2 nAChR")) - pmid:17640819 + pubmed:19126755 - a(HBP:"4-OH-GTS-21") causesNoChange bp(GO:locomotion) + a(CHEBI:nicotine) increases p(CONSO:"alpha-3 beta-2 nAChR") - pmid:17640819 + pubmed:18174175 - a(HBP:"4-OH-GTS-21") increases a(GO:perikaryon) + a(CHEBI:nicotine) increases p(CONSO:"alpha-3 beta-2 nAChR") - pmid:17640819 + pubmed:19126755 - a(HBP:"4-OH-GTS-21") causesNoChange a(MESH:"Cholinergic Neurons") + a(CHEBI:nicotine) increases p(CONSO:"alpha-3 beta-4 nAChR") - pmid:17640819 + pubmed:19126755 - a(HBP:"4-OH-GTS-21") decreases a(MESH:"Cholinergic Neurons") + a(CHEBI:nicotine) decreases complex(p(HGNC:CHRNA6), p(HGNC:CHRNB3)) + + + + + + + + - pmid:17640819 + pubmed:19126755 - a(HBP:"4-OH-GTS-21") causesNoChange a(MESH:"GABAergic Neurons") + a(CHEBI:nicotine) increases act(p(FPLX:PI3K)) - pmid:17640819 + pubmed:19293145 - a(HBP:"4-OH-GTS-21") causesNoChange a(CHEBI:"amyloid-beta") + a(CHEBI:nicotine) increases act(p(FPLX:PI3K)) - pmid:25514383 + pubmed:19293145 - a(PUBCHEM:9928899) increases bp(GO:"long-term synaptic potentiation") + a(CHEBI:nicotine) increases act(p(FPLX:PI3K)) - pmid:25514383 + pubmed:19126755 - a(CHEBI:"pregnenolone sulfate") increases bp(GO:cognition) + a(CHEBI:nicotine) increases act(p(FPLX:PKA)) - pmid:25514383 + pubmed:19126755 - a(CHEBI:"pregnenolone sulfate") increases bp(GO:"positive regulation of synaptic plasticity") + a(CHEBI:nicotine) increases act(p(FPLX:PKC)) - pmid:25514383 + pubmed:19126755 - a(CHEBI:"pregnenolone sulfate") increases bp(GO:"synaptic transmission, glutamatergic") + a(CHEBI:nicotine) increases act(p(FPLX:"CAMK2_complex")) - pmid:25514383 + pubmed:19126755 - a(CHEBI:"pregnenolone sulfate") increases path(MESH:"Spatial Memory") + act(a(CHEBI:nicotine)) increases act(p(FPLX:CREB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) - pmid:25514383 + pubmed:19126755 - a(CHEBI:"pregnenolone sulfate") decreases bp(GO:"apoptotic process") + act(a(CHEBI:nicotine)) increases act(p(HGNC:ATF2), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) - pmid:25514383 + pubmed:19126755 - a(CHEBI:simvastatin) regulates bp(GO:"cholesterol homeostasis") + act(a(CHEBI:nicotine)) increases act(p(RGD:Elk1), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) - pmid:25514383 + pubmed:19126755 - a(CHEBI:simvastatin) increases bp(GO:cognition) + act(a(CHEBI:nicotine)) increases act(p(HGNC:STAT3), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) - pmid:25514383 + pubmed:19293145 - a(CHEBI:simvastatin) decreases bp(GO:"apoptotic process") + a(CHEBI:nicotine) association act(p(HGNC:STAT3)) - pmid:29626319 + pubmed:19126755 - a(CHEBI:simvastatin) increases deg(a(CHEBI:"amyloid-beta")) + act(a(CHEBI:nicotine)) association a(MESH:Skin) - pmid:29626319 + pubmed:19126755 - a(CHEBI:simvastatin) increases bp(GO:"ERK1 and ERK2 cascade") + act(a(CHEBI:nicotine)) regulates bp(GO:"inflammatory response") - pmid:29626319 + pubmed:23178521 - a(CHEBI:simvastatin) increases sec(p(HGNC:MME)) + a(CHEBI:nicotine) regulates bp(GO:"inflammatory response") - pmid:21718217 + pubmed:19126755 - bp(GO:"cholesterol homeostasis") association p(HGNC:NR1H3) + a(CHEBI:nicotine) decreases path(MESH:"Colitis, Ulcerative") - + + + pubmed:19126755 + + a(CHEBI:nicotine) decreases path(MESH:"Inflammatory Bowel Diseases") + - pmid:25514383 + pubmed:19126755 - composite(a(CHEBI:simvastatin), p(MGI:App, frag("25_35"))) increases bp(GO:memory) + a(CHEBI:nicotine) decreases tloc(p(HGNC:TNF), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:25881725 + pubmed:19293145 - p(MGI:App, frag("25_35")) decreases bp(GO:learning) + a(CHEBI:nicotine) regulates act(p(HGNC:TNF)) - pmid:25881725 + pubmed:19126755 - p(MGI:App, frag("25_35")) decreases path(MESH:"Spatial Memory") + act(a(CHEBI:nicotine)) association path(MESH:"Genetic Variation") - pmid:25881725 + pubmed:19126755 - p(MGI:App, frag("25_35")) increases a(HBP:"amyloid-beta oligomers", loc(GO:"extracellular region")) + a(CHEBI:nicotine) causesNoChange path(MESH:"Alzheimer Disease") - pmid:25881725 + pubmed:19126755 - p(MGI:App, frag("25_35")) causesNoChange r(MGI:Chrna7) + a(CHEBI:nicotine) causesNoChange p(MGI:Chrna4) - - - + + + pubmed:19126755 + + a(CHEBI:nicotine) decreases act(a(CHEBI:NS-398)) + - pmid:25514383 + pubmed:19126755 - complex(a(CHEBI:"amyloid-beta"), p(FPLX:CHRN), p(HGNC:FLNA)) increases bp(GO:"intracellular signal transduction") + a(CHEBI:nicotine) decreases bp(GO:"neuron death") - + + + pubmed:19126755 + + a(CHEBI:nicotine) decreases bp(GO:"neuron death") + - pmid:25514383 + pubmed:19126755 - complex(p(HGNC:CHRNA7), p(HGNC:FLNA)) positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:nicotine) increases tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:25514383 + pubmed:17009926 - a(HBP:"PTI-125") decreases complex(p(HGNC:CHRNA7), p(HGNC:FLNA)) + a(CHEBI:nicotine) decreases tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:25514383 + pubmed:21482353 - a(HBP:"PTI-125") decreases complex(a(CHEBI:"amyloid-beta"), p(FPLX:CHRN)) + a(CHEBI:nicotine) decreases a(CHEBI:dopamine) - pmid:25514383 + pubmed:21482353 - a(HBP:"PTI-125") increases act(a(CHEBI:"amyloid-beta")) + a(CHEBI:nicotine) increases tloc(a(CHEBI:dopamine), fromLoc(MESH:"Presynaptic Terminals"), toLoc(GO:"extracellular region")) - pmid:27522251 + pubmed:19721446 - p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases path(MESH:"Memory Disorders") + a(CHEBI:nicotine) regulates tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:27522251 + pubmed:28391535 - p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases path(MESH:"Memory Disorders") + a(CHEBI:nicotine) increases tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:27522251 + pubmed:28391535 - p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases path(MESH:"Memory Disorders") + a(CHEBI:nicotine) increases act(a(CHEBI:dopamine)) - pmid:27522251 + pubmed:19126755 - p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases bp(GO:locomotion) + a(CHEBI:nicotine) increases path(MESH:"Behavior, Addictive") - pmid:27522251 + pubmed:19126755 - p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) causesNoChange path(MESH:Anxiety) + a(CHEBI:nicotine) increases path(MESH:Craving) - pmid:27522251 + pubmed:19126755 - p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) causesNoChange bp(GO:"microglial cell activation") + a(CHEBI:nicotine) increases path(MESH:Anxiety) - pmid:27522251 + pubmed:19126755 - p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) causesNoChange act(a(MESH:Neuroglia)) + a(CHEBI:nicotine) association act(p(HGNC:CHRNA7)) - pmid:27522251 + pubmed:19293145 - p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) causesNoChange bp(GO:"inflammatory response") + a(CHEBI:nicotine) increases p(HGNC:CHRNA7) - pmid:27522251 + pubmed:19293145 - p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases a(HBP:HBP00022) + a(CHEBI:nicotine) increases act(p(HGNC:CHRNA7)) - pmid:27522251 + pubmed:17009926 - p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases a(HBP:HBP00022) + a(CHEBI:nicotine) increases act(p(HGNC:CHRNA7)) - pmid:27522251 + pubmed:26472524 - p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases a(HBP:HBP00022) + a(CHEBI:nicotine) increases act(p(HGNC:CHRNA7)) - + + + pubmed:29428175 + + a(CHEBI:nicotine) directlyIncreases act(p(HGNC:CHRNA7)) + - pmid:27522251 + pubmed:29428175 - composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrnb2)) decreases path(MESH:"Memory Disorders") + a(CHEBI:nicotine) increases act(p(HGNC:CHRNA7), ma(GO:"calcium-induced calcium release activity")) - pmid:27522251 + pubmed:29428175 - composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrnb2)) decreases path(MESH:"Memory Disorders") + a(CHEBI:nicotine) increases act(p(HGNC:CHRNA7)) - pmid:27522251 + pubmed:19126755 - composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrnb2)) decreases a(HBP:HBP00022) + a(CHEBI:nicotine) association p(CONSO:"beta-2-containing nAChR") - + + + pubmed:19293145 + + a(CHEBI:nicotine) increases bp(MESH:Neuroprotection) + - pmid:27522251 + pubmed:19293145 - complex(a(CHEBI:"amyloid-beta"), p(MGI:Chrnb2)) increases path(MESH:"Memory Disorders") + act(a(CHEBI:nicotine)) increases bp(MESH:Neuroprotection) - + + + pubmed:19293145 + + act(a(CHEBI:nicotine)) increases bp(MESH:Neuroprotection) + - pmid:27522251 + pubmed:19293145 - composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrna7)) decreases path(MESH:"Memory Disorders") + act(a(CHEBI:nicotine)) increases bp(MESH:Neuroprotection) - pmid:27522251 + pubmed:19293145 - composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrna7)) decreases path(MESH:"Memory Disorders") + a(CHEBI:nicotine) increases bp(MESH:Neuroprotection) - pmid:27522251 + pubmed:19721446 - composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrna7)) decreases path(MESH:"Cognitive Dysfunction") + a(CHEBI:nicotine) association bp(MESH:Neuroprotection) - pmid:27522251 + pubmed:19293145 - composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrna7)) decreases a(HBP:HBP00022) + a(CHEBI:nicotine) increases path(MESH:Cognition) - pmid:24762290 + pubmed:19293145 - complex(HBP:"alpha-4 beta-2 nAChR") association a(MESH:Thalamus) + a(CHEBI:nicotine) decreases act(a(CHEBI:amyloid-beta)) - pmid:24762290 + pubmed:25514383 - complex(HBP:"alpha-4 beta-2 nAChR") association a(MESH:Thalamus) + a(CHEBI:nicotine) decreases a(CHEBI:amyloid-beta) - pmid:24762290 + pubmed:21958873 - complex(HBP:"alpha-4 beta-2 nAChR") association a(MESH:Pons) + a(CHEBI:nicotine) causesNoChange a(CHEBI:amyloid-beta) - pmid:24762290 + pubmed:19293145 - complex(HBP:"alpha-4 beta-2 nAChR") association a(MESH:Mesencephalon) + a(CHEBI:nicotine) increases a(CHEBI:acetylcholine) - pmid:24762290 + pubmed:19293145 - complex(HBP:"alpha-4 beta-2 nAChR") association a(MESH:"Corpus Striatum") + a(CHEBI:nicotine) increases complex(a(MESH:Bungarotoxins), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:24762290 + pubmed:19293145 - complex(HBP:"alpha-4 beta-2 nAChR") positiveCorrelation a(MESH:"White Matter") + a(CHEBI:nicotine) regulates composite(a(CHEBI:"3',5'-cyclic AMP"), p(FPLX:PKC)) - pmid:24762290 + pubmed:19293145 - complex(HBP:"alpha-4 beta-2 nAChR") association path(MESH:"Parkinson Disease") + a(CHEBI:nicotine) decreases act(a(CHEBI:thapsigargin)) - pmid:24762290 + pubmed:19293145 - complex(HBP:"alpha-4 beta-2 nAChR") association a(MESH:"Parietal Lobe") + act(a(CHEBI:nicotine)) decreases act(a(CHEBI:methamphetamine)) - pmid:24762290 + pubmed:19293145 - complex(HBP:"alpha-4 beta-2 nAChR") association path(MESH:Memory) + a(CHEBI:nicotine) association bp(GO:"negative regulation of apoptotic process") - pmid:24762290 + pubmed:19293145 - a(MESH:Pons) association complex(HBP:"alpha-4 beta-2 nAChR") + act(a(CHEBI:nicotine)) increases p(FPLX:AKT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:24762290 + pubmed:19293145 - a(MESH:Mesencephalon) association complex(HBP:"alpha-4 beta-2 nAChR") + act(a(CHEBI:nicotine)) increases p(HGNC:BCL2) - pmid:24762290 + pubmed:19293145 - a(MESH:"Parietal Lobe") association complex(HBP:"alpha-4 beta-2 nAChR") + act(a(CHEBI:nicotine)) increases p(HGNC:BCL2L1) - pmid:21718217 + pubmed:19293145 - a(HBP:HBP00089) association bp(GO:"microglial cell activation") + a(CHEBI:nicotine) decreases bp(GO:"apoptotic process") - pmid:21718217 + pubmed:19293145 - a(HBP:HBP00089) positiveCorrelation bp(GO:"microglial cell activation") + a(CHEBI:nicotine) decreases bp(GO:"apoptotic process") - pmid:21718217 + pubmed:25514383 - a(HBP:HBP00089) increases sec(p(HGNC:IFNG)) + a(CHEBI:nicotine) decreases bp(GO:"apoptotic process") - pmid:21718217 + pubmed:19293145 - a(HBP:HBP00089) increases sec(p(HGNC:TNF)) + a(CHEBI:nicotine) decreases tloc(p(HGNC:BAX), fromLoc(GO:cytosol), toLoc(GO:mitochondrion)) - pmid:21718217 + pubmed:19293145 - a(HBP:HBP00089) increases sec(p(HGNC:IL1B)) + a(CHEBI:nicotine) increases act(p(HGNC:BAD)) - pmid:21718217 + pubmed:19293145 - a(HBP:HBP00089) increases sec(p(HGNC:IL6)) + a(CHEBI:nicotine) increases complex(p(FPLX:"PI3K_p85"), p(HGNC:CHRNA7), p(HGNC:FYN)) - pmid:21718217 + pubmed:19293145 - a(HBP:HBP00089) increases sec(p(HGNC:CCL2)) + a(CHEBI:nicotine) increases act(p(HGNC:JAK2)) - pmid:22807490 + pubmed:19293145 - p(HGNC:IFNG) increases p(HGNC:NOS2) + act(a(CHEBI:nicotine)) increases p(HGNC:STAT3, pmod(go:0006468 ! "protein phosphorylation")) - pmid:23702978 + pubmed:23178521 - p(HGNC:IFNG) increases act(p(HGNC:NOS2)) + a(CHEBI:nicotine) association p(HGNC:STAT3, pmod(go:0006468 ! "protein phosphorylation")) - pmid:22807490 + pubmed:19293145 - p(HGNC:IFNG) increases p(HGNC:PTGS2) + act(a(CHEBI:nicotine)) increases p(RGD:Mapk3, pmod(go:0006468 ! "protein phosphorylation")) - pmid:23702978 + pubmed:19293145 - p(HGNC:IFNG) increases p(HGNC:AIM2) + act(a(CHEBI:nicotine)) increases p(RGD:Mapk14, pmod(go:0006468 ! "protein phosphorylation")) - pmid:23702978 + pubmed:19293145 - p(HGNC:IFNG) decreases act(p(HGNC:NLRP3)) + act(a(CHEBI:nicotine)) increases p(RGD:Stat3, pmod(go:0006468 ! "protein phosphorylation")) - pmid:23702978 + pubmed:19293145 - p(HGNC:IFNG) increases p(HGNC:CARD17) + a(CHEBI:nicotine) increases act(g(HGNC:NIN)) - pmid:21718217 + pubmed:19293145 - act(p(HGNC:PPARG)) increases path(MESH:"Alzheimer Disease") + a(CHEBI:nicotine) increases p(HGNC:PTGS2) - pmid:21718217 + pubmed:19293145 - act(p(HGNC:PPARG)) increases deg(a(CHEBI:"amyloid-beta")) + a(CHEBI:nicotine) increases a(CHEBI:"prostaglandin E2(1-)") + + - pmid:21718217 + pubmed:19293145 - act(p(HGNC:PPARG)) increases bp(GO:"reverse cholesterol transport") + a(CHEBI:nicotine) increases bp(GO:"ERK1 and ERK2 cascade") - pmid:21718217 + pubmed:19293145 - act(p(HGNC:PPARG)) decreases bp(GO:"microglial cell activation involved in immune response") + a(CHEBI:nicotine) increases bp(GO:"MAPK cascade") - pmid:21718217 + pubmed:19293145 - p(HGNC:PPARG) association bp(MESH:"Energy Metabolism") + act(a(CHEBI:nicotine)) increases composite(p(FPLX:JAK), p(HGNC:STAT3)) - pmid:21718217 + pubmed:19293145 - p(HGNC:PPARG) increases bp(GO:"fat cell differentiation") + a(CHEBI:nicotine) decreases act(a(CHEBI:"N-methyl-D-aspartic acid")) - pmid:21718217 + pubmed:19293145 - p(HGNC:PPARG) association bp(GO:"response to insulin") + a(CHEBI:nicotine) decreases a(MESH:Lipopolysaccharides) - pmid:21718217 + pubmed:19293145 - p(HGNC:PPARG) association bp(GO:"lipid storage") + a(CHEBI:nicotine) association bp(GO:"calcium-mediated signaling") - pmid:21718217 + pubmed:19293145 - p(HGNC:PPARG) increases p(HGNC:APOE) + a(CHEBI:nicotine) association p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors") - pmid:21718217 + pubmed:19293145 - p(HGNC:PPARG) increases p(HGNC:ABCA1) + a(CHEBI:nicotine) association p(HGNCGENEFAMILY:"Ryanodine receptors") - pmid:21718217 + pubmed:19293145 - p(HGNC:PPARG) increases p(HGNC:NR1H3) + a(CHEBI:nicotine) association p(FPLX:ERK) - pmid:21718217 + pubmed:19293145 - act(p(HGNC:PPARG)) increases p(HGNC:ARG1) + act(a(CHEBI:nicotine)) association a(MESH:Calcineurin) - pmid:21718217 + pubmed:19293145 - act(p(HGNC:PPARG)) increases p(HGNC:IL4) + a(CHEBI:nicotine) increases a(CHEBI:"calcium(2+)") + + - pmid:21718217 + pubmed:19293145 - act(p(HGNC:NR1H3)) increases path(MESH:"Alzheimer Disease") + a(CHEBI:nicotine) decreases p(CONSO:sAPP-gamma) + + - pmid:21718217 + pubmed:17009926 - act(p(HGNC:NR1H3)) increases deg(a(CHEBI:"amyloid-beta")) + a(CHEBI:nicotine) increases act(p(FPLX:CHRN)) - pmid:21718217 + pubmed:17009926 - act(p(HGNC:NR1H3)) increases deg(a(CHEBI:"amyloid-beta")) + a(CHEBI:nicotine) increases act(p(FPLX:CHRN)) - pmid:21718217 + pubmed:17009926 - act(p(HGNC:NR1H3)) increases bp(GO:"reverse cholesterol transport") + a(CHEBI:nicotine) increases act(p(FPLX:CHRN)) - pmid:21718217 + pubmed:28445721 - act(p(HGNC:NR1H3)) decreases bp(GO:"microglial cell activation involved in immune response") + a(CHEBI:nicotine) regulates p(FPLX:CHRN) - pmid:21718217 + pubmed:21482353 - p(HGNC:NR1H3) association bp(GO:"cholesterol homeostasis") + a(CHEBI:nicotine) increases act(p(FPLX:CHRN)) - pmid:21718217 + pubmed:21482353 - p(HGNC:NR1H3) association bp(GO:"negative regulation of inflammatory response") + a(CHEBI:nicotine) increases p(FPLX:CHRN) - pmid:21718217 + pubmed:21482353 - p(HGNC:NR1H3) increases p(HGNC:APOE) + a(CHEBI:nicotine) increases p(FPLX:CHRN) - pmid:21718217 + pubmed:21482353 - act(p(HGNC:NR1H3)) increases act(p(HGNC:APOE)) + a(CHEBI:nicotine) causesNoChange p(FPLX:CHRN) - pmid:21718217 + pubmed:21787755 - p(HGNC:NR1H3) increases p(HGNC:ABCA1) + a(CHEBI:nicotine) increases act(p(FPLX:CHRN)) - pmid:21718217 + pubmed:17009926 - act(p(HGNC:NR1H3)) increases bp(GO:memory) + a(CHEBI:nicotine) increases bp(GO:memory) - pmid:21718217 + pubmed:25514383 - act(p(HGNC:NR1H3)) decreases bp(GO:"microglial cell activation") + a(CHEBI:nicotine) increases bp(GO:memory) - + + + pubmed:11230871 + + a(CHEBI:nicotine) increases bp(GO:memory) + - pmid:21718217 + pubmed:11230871 - p(FPLX:PPAR) association bp(MESH:"Energy Metabolism") + a(CHEBI:nicotine) increases bp(GO:memory) - pmid:21718217 + pubmed:17009926 - p(FPLX:PPAR) positiveCorrelation bp(MESH:"Energy Metabolism") + a(CHEBI:nicotine) increases bp(GO:"circadian sleep/wake cycle, wakefulness") + + + + + + - pmid:21718217 + pubmed:22530628 - p(FPLX:PPAR) association bp(GO:"fat cell differentiation") + a(CHEBI:nicotine) decreases path(DOID:"Alzheimer's disease") - pmid:21718217 + pubmed:22530628 - p(FPLX:PPAR) positiveCorrelation bp(GO:"fat cell differentiation") + a(CHEBI:nicotine) positiveCorrelation path(MESH:Attention) - pmid:21718217 + pubmed:11230871 - p(FPLX:PPAR) association bp(GO:"response to insulin") + a(CHEBI:nicotine) increases path(MESH:Attention) - pmid:21718217 + pubmed:22530628 - p(FPLX:PPAR) positiveCorrelation bp(GO:"response to insulin") + a(CHEBI:nicotine) causesNoChange bp(GO:"learning or memory") - pmid:21718217 + pubmed:22530628 - p(FPLX:PPAR) association bp(GO:"response to tumor cell") + a(CHEBI:nicotine) increases path(NCIT:C28004) - pmid:21718217 + pubmed:22530628 - p(FPLX:PPAR) positiveCorrelation bp(GO:"response to tumor cell") + a(CHEBI:nicotine) increases path(MESH:Tachyphylaxis) - pmid:21718217 + pubmed:30697142 - p(FPLX:PPAR) regulates bp(GO:"lipid metabolic process") + a(CHEBI:nicotine) increases path(MESH:Tachyphylaxis) - pmid:21718217 + pubmed:22530628 - act(p(FPLX:PPAR)) decreases bp(GO:"microglial cell activation") + a(CHEBI:nicotine) increases path(MESH:"Tobacco Use Disorder") - pmid:21718217 + pubmed:30697142 - act(p(FPLX:RXR)) increases p(HGNC:APOE) + a(CHEBI:nicotine) increases path(MESH:"Tobacco Use Disorder") - pmid:21718217 + pubmed:30697142 - act(p(FPLX:RXR)) increases p(HGNC:ABCA1) + a(CHEBI:nicotine) increases path(MESH:"Tobacco Use Disorder") @@ -80241,2845 +80950,2816 @@

Statements

- pmid:21718217 + pubmed:26813123 - bp(MESH:"Energy Metabolism") association p(FPLX:PPAR) + a(CHEBI:nicotine) increases act(a(MESH:"Receptors, Nicotinic")) - pmid:21718217 + pubmed:21958873 - bp(MESH:"Energy Metabolism") positiveCorrelation p(FPLX:PPAR) + a(CHEBI:nicotine) increases act(a(MESH:"Receptors, Nicotinic")) + + - pmid:21718217 + pubmed:29428175 - bp(MESH:"Energy Metabolism") association p(HGNC:PPARG) + a(CHEBI:nicotine) increases bp(MESH:"Calcium Signaling") - pmid:21718217 + pubmed:29428175 - bp(MESH:"Energy Metabolism") association p(HGNC:PPARGC1A) + a(CHEBI:nicotine) regulates bp(GO:"T cell proliferation") - pmid:30012004 + pubmed:29428175 - bp(MESH:"Energy Metabolism") negativeCorrelation path(MESH:"Huntington Disease") + a(CHEBI:nicotine) regulates bp(GO:"cytokine secretion") - - - pmid:25784053 - - bp(MESH:"Energy Metabolism") association p(HGNC:HSPD1) - + - pmid:21718217 + pubmed:26979166 - bp(GO:"fat cell differentiation") association p(FPLX:PPAR) + a(CHEBI:nicotine) decreases bp(GO:"microglial cell activation") - pmid:21718217 + pubmed:26979166 - bp(GO:"fat cell differentiation") positiveCorrelation p(FPLX:PPAR) + a(CHEBI:nicotine) decreases path(CONSO:neuroinflammation) - pmid:21718217 + pubmed:26979166 - bp(GO:"response to insulin") association p(FPLX:PPAR) + a(CHEBI:nicotine) decreases deg(a(MESH:"Dopaminergic Neurons")) - pmid:21718217 + pubmed:21482353 - bp(GO:"response to insulin") positiveCorrelation p(FPLX:PPAR) + a(CHEBI:nicotine) decreases act(a(MESH:"Dopaminergic Neurons")) - - - pmid:21718217 - - bp(GO:"response to insulin") association p(HGNC:PPARG) - + - pmid:21718217 + pubmed:25514383 - bp(GO:"response to tumor cell") association p(FPLX:PPAR) + a(CHEBI:nicotine) decreases a(CHEBI:"amyloid-beta polypeptide 42") - pmid:21718217 + pubmed:25514383 - bp(GO:"response to tumor cell") positiveCorrelation p(FPLX:PPAR) + a(CHEBI:nicotine) decreases a(CHEBI:"amyloid-beta polypeptide 42") - pmid:21718217 + pubmed:25514383 - bp(GO:"lipid storage") association p(HGNC:PPARG) + a(CHEBI:nicotine) decreases a(CHEBI:"amyloid-beta polypeptide 40") - pmid:21718217 + pubmed:25514383 - p(HGNC:PPARD) association bp(GO:"fatty acid oxidation") + a(CHEBI:nicotine) decreases a(CHEBI:"amyloid-beta polypeptide 40") - pmid:21718217 + pubmed:25514383 - act(p(HGNC:PPARD)) increases bp(GO:"reverse cholesterol transport") + a(CHEBI:nicotine) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") - pmid:21718217 + pubmed:25514383 - act(p(HGNC:PPARD)) increases bp(GO:"negative regulation of inflammatory response") + a(CHEBI:nicotine) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) - pmid:21718217 + pubmed:25514383 - act(p(HGNC:PPARD)) increases p(HGNC:ARG1) + a(CHEBI:nicotine) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") - pmid:21718217 + pubmed:21482353 - act(p(HGNC:PPARD)) increases p(HGNC:IL4) + a(CHEBI:nicotine) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) - pmid:21718217 + pubmed:21482353 - bp(GO:"fatty acid oxidation") association p(HGNC:PPARD) + a(CHEBI:nicotine) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) - pmid:21718217 + pubmed:25514383 - a(CHEBI:oxysterol) increases act(p(HGNC:NR1H3)) + a(CHEBI:nicotine) increases path(MESH:"Memory, Episodic") - pmid:21718217 + pubmed:25514383 - a(CHEBI:oxysterol) increases act(p(HGNC:NR1H3)) + a(CHEBI:nicotine) increases path(MESH:"Spatial Memory") - pmid:21718217 + pubmed:25514383 - bp(GO:"negative regulation of inflammatory response") association p(HGNC:NR1H3) + a(CHEBI:nicotine) decreases a(CONSO:"amyloid-beta oligomers") - pmid:21718217 + pubmed:25514383 - a(HBP:HBP00030) positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:nicotine) increases a(CONSO:"Tau aggregates") - pmid:21718217 + pubmed:25514383 - a(HBP:HBP00030) increases a(HBP:HBP00018) + a(CHEBI:nicotine) increases a(CONSO:"Tau aggregates") - pmid:21718217 + pubmed:25514383 - p(HGNC:ABCA1) increases p(HGNC:APOE) + a(CHEBI:nicotine) increases bp(GO:"p38MAPK cascade") - pmid:21718217 + pubmed:25514383 - p(HGNC:ABCA1) decreases a(HBP:HBP00018) + a(CHEBI:nicotine) decreases path(MESH:"Plaque, Amyloid") - pmid:21718217 + pubmed:19721446 - p(HGNC:IDE) increases deg(a(CHEBI:"amyloid-beta")) + a(CHEBI:nicotine) decreases path(MESH:"Plaque, Amyloid") - pmid:30116051 + pubmed:25514383 - p(HGNC:IDE) increases deg(a(CHEBI:"amyloid-beta")) + a(CHEBI:nicotine) increases bp(GO:"long-term synaptic potentiation") - pmid:26195256 + pubmed:21482353 - p(HGNC:IDE) increases deg(a(CHEBI:"amyloid-beta", loc(GO:intracellular))) + a(CHEBI:nicotine) increases bp(GO:"long-term synaptic potentiation") - pmid:26195256 + pubmed:30697142 - p(HGNC:IDE) increases deg(a(CHEBI:"amyloid-beta", loc(GO:"extracellular region"))) + a(CHEBI:nicotine) increases a(CHEBI:"(-)-cotinine") - pmid:26195256 + pubmed:30697142 - p(HGNC:IDE) increases deg(a(CHEBI:"amyloid-beta")) + a(CHEBI:nicotine) increases a(CHEBI:nornicotine) - pmid:26195256 + pubmed:30697142 - p(HGNC:IDE) decreases a(CHEBI:"amyloid-beta") + a(CHEBI:nicotine) increases a(CHEBI:nornicotine) - pmid:29626319 + pubmed:30697142 - p(HGNC:IDE) increases deg(a(CHEBI:"amyloid-beta")) + a(CHEBI:nicotine) increases a(CHEBI:Norcotinine) + + - pmid:29626319 + pubmed:30697142 - p(HGNC:IDE) increases deg(a(CHEBI:"amyloid-beta")) + a(CHEBI:nicotine) increases a(CHEBI:"nicotine N(1')-oxide") - pmid:29626319 + pubmed:30697142 - p(HGNC:IDE) increases deg(a(CHEBI:"amyloid-beta")) + a(CHEBI:nicotine) increases a(MESH:"nicotine N-glucuronide") - pmid:28019679 + pubmed:30697142 - p(HGNC:IDE) decreases a(CHEBI:"amyloid-beta") + a(CHEBI:nicotine) increases a(CHEBI:"4-oxo-4-(pyridin-3-yl)butanoic acid") - pmid:30116051 + pubmed:30697142 - p(HGNC:IDE) increases deg(p(HGNC:IAPP)) + a(CHEBI:nicotine) increases a(CHEBI:"butyric acid") - pmid:30116051 + pubmed:30697142 - p(HGNC:IDE) decreases a(HBP:"alpha-synuclein aggregates") + a(CHEBI:nicotine) increases a(PUBCHEM:25203099) - pmid:30116051 + pubmed:30697142 - p(HGNC:IDE) decreases a(HBP:"amyloid-beta aggregates") + a(CHEBI:nicotine) increases path(MESH:"Substance Withdrawal Syndrome") - pmid:30116051 + pubmed:30697142 - p(HGNC:IDE) increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + a(CHEBI:nicotine) increases path(MESH:"Cardiovascular Deconditioning") + + - pmid:30116051 + pubmed:28445721 - p(HGNC:IDE) increases bp(GO:macroautophagy) + a(CHEBI:nicotine) increases tloc(p(CONSO:CONSO00174), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) + + - pmid:30116051 + pubmed:21482353 - p(HGNC:IDE) decreases a(HBP:"alpha-synuclein fibrils") + a(CHEBI:nicotine) increases complex(p(HGNC:CHRNA4), p(HGNC:CHRNA4), p(HGNC:CHRNB2), p(HGNC:CHRNB2), p(HGNC:CHRNB2)) - pmid:30116051 + pubmed:21482353 - p(HGNC:IDE) increases deg(a(HBP:"alpha-synuclein fibrils")) + a(CHEBI:nicotine) increases act(p(MGI:Lynx1)) - pmid:26195256 + pubmed:21482353 - p(HGNC:IDE) increases deg(p(HGNC:INS)) + a(CHEBI:nicotine) increases bp(GO:cognition) - pmid:29626319 + pubmed:19721446 - p(HGNC:IDE) negativeCorrelation bp(GO:aging) + a(CHEBI:nicotine) increases bp(GO:cognition) - pmid:29626319 + pubmed:21482353 - p(HGNC:IDE) negativeCorrelation path(MESH:"Diabetes Mellitus") + a(CHEBI:nicotine) causesNoChange p(CONSO:"alpha-4-containing nAChR") - pmid:28019679 + pubmed:21482353 - p(HGNC:IDE) regulates complex(GO:"NLRP3 inflammasome complex") + a(CHEBI:nicotine) increases act(p(CONSO:"alpha-4-containing nAChR")) - pmid:21718217 + pubmed:21482353 - a(CHEBI:"GW 3965") directlyIncreases act(p(HGNC:NR1H3)) + a(CHEBI:nicotine) increases act(p(CONSO:"alpha-4-containing nAChR")) - pmid:21718217 + pubmed:21482353 - a(CHEBI:"GW 3965") increases act(p(HGNC:NR1H3)) + a(CHEBI:nicotine) increases tloc(p(CONSO:"alpha-4-containing nAChR"), fromLoc(GO:"endoplasmic reticulum"), toLoc(GO:"extracellular region")) - pmid:21718217 + pubmed:21482353 - a(CHEBI:"GW 3965") increases p(HGNC:APOE) + a(CHEBI:nicotine) increases act(a(MESH:"GABAergic Neurons")) - pmid:21718217 + pubmed:21482353 - a(CHEBI:"GW 3965") increases p(HGNC:ABCA1) + a(CHEBI:nicotine) decreases path(CONSO:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") - pmid:21718217 + pubmed:11230871 - a(CHEBI:"GW 3965") decreases a(HBP:HBP00018) + a(CHEBI:nicotine) increases bp(GO:learning) - pmid:21718217 + pubmed:19721446 - a(CHEBI:"GW 3965") increases bp(GO:memory) + a(CHEBI:nicotine) increases bp(MESH:"Sensory Gating") - pmid:21718217 + pubmed:19721446 - a(CHEBI:"GW 3965") decreases path(MESH:Inflammation) + act(a(CHEBI:nicotine)) decreases path(MESH:Nociception) - pmid:21718217 + pubmed:22040696 - a(CHEBI:"GW 3965") increases act(a(HBP:HBP00038)) + a(CHEBI:nicotine) increases act(a(MESH:"SNARE Proteins")) - pmid:21718217 + pubmed:18174175 - a(CHEBI:"GW 3965") increases bp(GO:phagocytosis) + a(CHEBI:nicotine) increases complex(a(CHEBI:epibatidine), a(MESH:"alpha6beta2 nicotinic acetylcholine receptor")) - pmid:21718217 + pubmed:18174175 - p(MGI:Abca1) decreases a(CHEBI:"amyloid-beta") + a(CHEBI:nicotine) increases a(MESH:"alpha6beta2 nicotinic acetylcholine receptor") + + + + + + + + - pmid:21718217 + pubmed:21958873 - p(MGI:Abca1) decreases a(HBP:HBP00038) + a(CHEBI:nicotine) causesNoChange tloc(p(CONSO:sAPP-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:21718217 + pubmed:21958873 - a(CHEBI:pioglitazone) increases act(p(HGNC:PPARG)) + a(CHEBI:nicotine) causesNoChange tloc(p(CONSO:sAPP-alpha), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:21718217 + pubmed:21958873 - a(CHEBI:pioglitazone) decreases path(MESH:"Diabetes Mellitus, Type 2") + a(CHEBI:nicotine) causesNoChange act(complex(GO:"NF-kappaB complex")) - pmid:21718217 + pubmed:23178521 - a(CHEBI:pioglitazone) decreases a(HBP:HBP00018) + a(CHEBI:nicotine) decreases act(p(MESH:"NF-kappa B")) - pmid:21718217 + pubmed:28391535 - a(CHEBI:pioglitazone) decreases a(HBP:HBP00018) + a(CHEBI:nicotine) increases act(a(MESH:"Adrenal Glands")) - pmid:21718217 + pubmed:28391535 - a(CHEBI:pioglitazone) decreases a(CHEBI:"amyloid-beta polypeptide 42") + a(CHEBI:nicotine) increases tloc(a(CHEBI:adrenaline), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:21718217 + pubmed:28391535 - a(CHEBI:pioglitazone) increases bp(GO:behavior) + a(CHEBI:nicotine) decreases tloc(a(CHEBI:"insulin (human)"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:21718217 + pubmed:28391535 - a(CHEBI:pioglitazone) increases p(MGI:Abca1) + a(CHEBI:nicotine) association complex(p(GO:"I-kappaB/NF-kappaB complex")) + + - pmid:21718217 + pubmed:28391535 - a(CHEBI:pioglitazone) increases p(MGI:Apoe) + a(CHEBI:nicotine) increases complex(a(CHEBI:nicotine), a(MESH:"nicotinic receptor alpha4beta2")) - pmid:21718217 + pubmed:28391535 - a(CHEBI:pioglitazone) increases bp(GO:memory) + a(CHEBI:nicotine) increases complex(a(CHEBI:nicotine), a(MESH:"nicotinic receptor alpha4beta2")) - pmid:21718217 + pubmed:28391535 - a(CHEBI:pioglitazone) increases bp(GO:cognition) + a(CHEBI:nicotine) negativeCorrelation path(MESH:"Motor Activity") + + + + - pmid:29626319 + pubmed:28391535 - a(CHEBI:pioglitazone) decreases a(CHEBI:"amyloid-beta") + a(CHEBI:nicotine) increases complex(a(CHEBI:nicotine), a(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:21718217 + pubmed:28391535 - a(CHEBI:rosiglitazone) increases act(p(HGNC:PPARG)) + a(CHEBI:nicotine) causesNoChange act(a(CHEBI:Mecamylamine)) - pmid:21718217 + pubmed:28391535 - a(CHEBI:rosiglitazone) increases act(p(HGNC:PPARG)) + act(a(CHEBI:nicotine)) negativeCorrelation a(CHEBI:Hexamethonium) - pmid:29626319 + pubmed:28843454 - a(CHEBI:rosiglitazone) increases act(p(HGNC:PPARG)) + a(MESH:"Tobacco Smoke Pollution") increases path(DOID:"multiple sclerosis") - pmid:21718217 + pubmed:28843454 - a(CHEBI:rosiglitazone) decreases path(MESH:"Diabetes Mellitus, Type 2") + path(EFO:"developmental disability") association path(ORPHANET:477738) - pmid:21718217 + pubmed:28843454 - a(CHEBI:rosiglitazone) increases bp(GO:behavior) + path(EFO:"developmental disability") association path(DOID:"multiple sclerosis") - pmid:21718217 + pubmed:28843454 - a(CHEBI:rosiglitazone) causesNoChange a(HBP:HBP00018) + path(MESH:"Pediatric Obesity") increases path(ORPHANET:477738) - pmid:21718217 + pubmed:28843454 - a(CHEBI:rosiglitazone) decreases a(HBP:HBP00018) + path(MESH:"Body Weight") increases path(ORPHANET:477738) - pmid:21718217 + pubmed:28843454 - a(CHEBI:rosiglitazone) decreases a(CHEBI:"amyloid-beta polypeptide 42") + path(MESH:"Body Mass Index") increases path(ORPHANET:477738) - pmid:21718217 + pubmed:28843454 - a(CHEBI:rosiglitazone) decreases a(CHEBI:"amyloid-beta") + bp(MESH:"Diet, Sodium-Restricted") positiveCorrelation path(EFO:"autoimmune disease") - pmid:29626319 + pubmed:28843454 - a(CHEBI:rosiglitazone) increases deg(a(CHEBI:"amyloid-beta")) + bp(MESH:"Diet, Sodium-Restricted") decreases p(MESH:"Th17 Cells", var("?")) - pmid:21718217 + pubmed:28843454 - a(CHEBI:rosiglitazone) increases bp(GO:"learning or memory") + bp(MESH:"Diet, Sodium-Restricted") decreases path(EFO:"experimental autoimmune encephalomyelitis") - pmid:21718217 + pubmed:28843454 - a(CHEBI:rosiglitazone) increases p(MGI:Ctnnb1) + path(EFO:"autoimmune disease") positiveCorrelation bp(MESH:"Diet, Sodium-Restricted") - pmid:21718217 + pubmed:28843454 - a(CHEBI:rosiglitazone) decreases p(MGI:Gsk3b) + p(MESH:"Th17 Cells", var("?")) increases path(EFO:"experimental autoimmune encephalomyelitis") + + - pmid:21718217 + pubmed:28843454 - a(CHEBI:rosiglitazone) increases p(MGI:Abca1) + path(MESH:"Gastrointestinal Microbiome") regulates a(MESH:"Immune System") - pmid:21718217 + pubmed:28843454 - a(CHEBI:rosiglitazone) increases bp(GO:memory) + path(MESH:"Gastrointestinal Microbiome") regulates path(MESH:Immunity) - pmid:21718217 + pubmed:28843454 - a(CHEBI:rosiglitazone) increases bp(GO:cognition) + path(MESH:"Gastrointestinal Microbiome") regulates bp(GO:"immune response") - pmid:29626319 + pubmed:27794524 - a(CHEBI:rosiglitazone) increases act(a(MESH:Microglia)) + path(MESH:Immunity) causesNoChange act(p(MESH:B-Lymphocytes)) - pmid:19732809 + pubmed:28843454 - path(MESH:"Diabetes Mellitus, Type 2") negativeCorrelation p(MESH:Proteins, pmod(HBP:"O-GlcNAcylation")) + p(HGNCGENEFAMILY:"Histocompatibility complex") increases path(DOID:"multiple sclerosis") - pmid:22798221 + pubmed:28843454 - act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 404)) + p(HGNCGENEFAMILY:"Histocompatibility complex") association bp(GO:"immune response") - pmid:22798221 + pubmed:30967783 - act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 198)) + p(HGNCGENEFAMILY:"Histocompatibility complex") increases bp(GO:"T cell activation") - pmid:22798221 + pubmed:28843454 - act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 199)) + g(HGNCGENEFAMILY:"Histocompatibility complex") increases p(MESH:"Membrane Glycoproteins") - pmid:22798221 + pubmed:26445701 - act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 202)) + g(HGNCGENEFAMILY:"Histocompatibility complex") positiveCorrelation path(DOID:"multiple sclerosis") - pmid:22798221 + pubmed:28843454 - act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 231)) + p(MESH:"Membrane Glycoproteins") increases bp(GO:"T cell antigen processing and presentation") - pmid:22798221 + pubmed:28843454 - act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 396)) + g(IMGTHLA:HLA00865) positiveCorrelation path(DOID:"multiple sclerosis") - pmid:22798221 + pubmed:28843454 - act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 205)) + p(IMGTHLA:HLA00870) increases path(DOID:"multiple sclerosis") - pmid:22798221 + pubmed:28843454 - act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) + p(MESH:"HLA Antigens") decreases path(DOID:"multiple sclerosis") - - - pmid:29121589 + pubmed:28843454 - act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Dpysl2, pmod(Ph)) + a(MESH:"DNA, Mitochondrial") association path(DOID:"multiple sclerosis") - pmid:29121589 + pubmed:24561250 - act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph)) + deg(a(MESH:"DNA, Mitochondrial")) increases act(complex(GO:"inflammasome complex")) - - - - - pmid:21718217 + pubmed:28843454 - a(CHEBI:"GW 501516") increases act(p(HGNC:PPARD)) + bp(MESH:"Oxidative Phosphorylation") positiveCorrelation path(MESH:"Energy Metabolism") - pmid:21718217 + pubmed:28843454 - a(CHEBI:"GW 501516") increases p(HGNC:ABCA1) + path(MESH:"Energy Metabolism") positiveCorrelation bp(MESH:"Oxidative Phosphorylation") - pmid:21718217 + pubmed:27794524 - a(CHEBI:"GW 501516") increases p(HGNC:APOA1) + path(MESH:"Energy Metabolism") directlyDecreases path(MESH:"Nerve Degeneration") - pmid:21718217 + pubmed:27794524 - a(CHEBI:"GW 501516") decreases a(HBP:HBP00018) + path(MESH:"Energy Metabolism") directlyDecreases bp(GO:"cell death") - pmid:21718217 + pubmed:27956442 - a(CHEBI:"GW 501516") increases p(HGNC:MME) + path(MESH:"Energy Metabolism") negativeCorrelation bp(GO:"transport across blood-brain barrier") - pmid:21718217 + pubmed:27956442 - a(CHEBI:"GW 501516") increases p(HGNC:IDE) + path(MESH:"Energy Metabolism") negativeCorrelation path(MESH:Inflammation) - pmid:21718217 + pubmed:27956442 - a(CHEBI:"all-trans-retinoic acid") increases act(p(FPLX:RXR)) + path(MESH:"Energy Metabolism") decreases path(MESH:"Amnesia, Anterograde") - pmid:21718217 + pubmed:27956442 - a(CHEBI:"all-trans-retinoic acid") increases act(p(FPLX:RAR)) + path(MESH:"Energy Metabolism") decreases path(MESH:"Amnesia, Retrograde") - pmid:21718217 + pubmed:28843454 - a(CHEBI:"all-trans-retinoic acid") decreases a(HBP:HBP00018) + p(HGNC:HLA-DRB1) association path(DOID:"multiple sclerosis") - pmid:21718217 + pubmed:28843454 - a(CHEBI:"all-trans-retinoic acid") decreases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:HLA-DRB1) causesNoChange path(DOID:"multiple sclerosis") - pmid:21718217 + pubmed:28843454 - a(CHEBI:"all-trans-retinoic acid") increases bp(GO:memory) + p(HGNC:HLA-DRB1) increases path(DOID:"multiple sclerosis") - pmid:26400044 + pubmed:28843454 - a(CHEBI:"all-trans-retinoic acid") decreases path(MESH:"Plaque, Amyloid") + p(HGNC:HLA-DRB1) increases path(DOID:"multiple sclerosis") - pmid:26400044 + pubmed:28843454 - a(CHEBI:"all-trans-retinoic acid") decreases bp(HBP:"APP processing") + p(HGNC:HLA-DRB1) increases path(ORPHANET:477738) - pmid:26400044 + pubmed:28843454 - a(CHEBI:"all-trans-retinoic acid") decreases a(CHEBI:"amyloid-beta") + bp(GO:"DNA hypomethylation") increases p(HGNC:PADI2) - pmid:26400044 + pubmed:28843454 - a(CHEBI:"all-trans-retinoic acid") decreases act(p(MGI:Cdk5), ma(kin)) + p(HGNC:PADI2) increases p(HGNC:MBP, var("?")) - pmid:26400044 + pubmed:28843454 - a(CHEBI:"all-trans-retinoic acid") decreases act(p(MGI:Gsk3b), ma(kin)) + p(HGNC:PADI2) decreases path(MESH:"Immune Tolerance") - pmid:26400044 + pubmed:28843454 - a(CHEBI:"all-trans-retinoic acid") decreases a(HBP:"Tau aggregates") + p(HGNC:MBP, var("?")) decreases path(MESH:"Immune Tolerance") + + - pmid:26400044 + pubmed:26445701 - a(CHEBI:"all-trans-retinoic acid") decreases p(MGI:Mapt, pmod(Ph)) + p(HGNC:MBP) association a(MESH:"Glatiramer Acetate") - pmid:27181519 + pubmed:26445701 - a(CHEBI:"all-trans-retinoic acid") association bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") + p(HGNC:MBP) isA a(MESH:Autoantigens) + + - pmid:27181519 + pubmed:28843454 - a(CHEBI:"all-trans-retinoic acid") association bp(GO:autophagy) + g(HGNC:IFNG, var("NCIT:C121521")) increases p(HGNC:IFNG) + + - pmid:27181519 + pubmed:28843454 - a(CHEBI:"all-trans-retinoic acid") negativeCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") + p(HGNC:IFNG) regulates bp(GO:"immune response") - pmid:21718217 + pubmed:28843454 - a(CHEBI:bexarotene) increases act(p(FPLX:RXR)) + p(HGNC:IFNG) regulates bp(GO:"T cell differentiation") - pmid:21718217 + pubmed:27794524 - a(CHEBI:bexarotene) increases p(HGNC:APOE) + p(HGNC:IFNG) negativeCorrelation bp(GO:"glutamate homeostasis") + + - pmid:21718217 + pubmed:27794524 - a(CHEBI:bexarotene) increases p(HGNC:ABCA1) + p(HGNC:IFNG) directlyDecreases a(MESH:Oligodendroglia) - pmid:21718217 + pubmed:30967783 - a(CHEBI:bexarotene) decreases a(HBP:HBP00018) + p(HGNC:IFNG) increases a(NCIT:C156004) - pmid:21718217 + pubmed:20100581 - a(CHEBI:bexarotene) increases bp(GO:behavior) + p(HGNC:IFNG) increases bp(GO:"microglial cell activation") - pmid:27181519 + pubmed:20100581 - a(CHEBI:bexarotene) isA a(CHEBI:"retinoid X receptor agonist") + p(HGNC:IFNG) increases bp(GO:"astrocyte activation") - pmid:27181519 + pubmed:20100581 - a(CHEBI:bexarotene) decreases path(MESH:"Motor Neuron Disease") + p(HGNC:IFNG) association p(HGNC:NOS1) - pmid:27181519 + pubmed:22807490 - a(CHEBI:bexarotene) decreases path(MESH:"Amyotrophic Lateral Sclerosis") + p(HGNC:IFNG) increases p(HGNC:NOS2) - pmid:21718217 + pubmed:23702978 - a(CHEBI:Honokiol) increases act(p(FPLX:RXR)) + p(HGNC:IFNG) increases act(p(HGNC:NOS2)) - pmid:21718217 + pubmed:22807490 - a(CHEBI:Honokiol) increases act(complex(p(FPLX:RXR), p(HGNC:NR1H3))) + p(HGNC:IFNG) increases p(HGNC:PTGS2) - pmid:21718217 + pubmed:23702978 - a(CHEBI:Honokiol) increases p(HGNC:APOE) + p(HGNC:IFNG) increases p(HGNC:AIM2) - pmid:21718217 + pubmed:23702978 - a(CHEBI:Honokiol) increases p(HGNC:ABCA1) + p(HGNC:IFNG) decreases act(p(HGNC:NLRP3)) - pmid:21718217 + pubmed:23702978 - r(HGNC:ARG1) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:IFNG) increases p(HGNC:CARD17) + + + + - pmid:11230871 + pubmed:28843454 - bp(MESH:"Lipid Peroxidation") decreases p(FPLX:CHRN) + g(HGNC:FOXP3, var("NCIT:C121521")) increases p(HGNC:FOXP3) + + - pmid:21718217 + pubmed:28843454 - p(HGNC:PPARGC1A) association bp(MESH:"Energy Metabolism") + p(HGNC:FOXP3) regulates bp(GO:"immune response") - pmid:21718217 + pubmed:28843454 - p(HGNC:PPARGC1A) association path(MESH:"Insulin Resistance") + p(HGNC:FOXP3) regulates bp(GO:"T cell differentiation") - pmid:21718217 + pubmed:28843454 - p(HGNC:PPARGC1A) increases bp(GO:"fat cell differentiation") + g(HGNC:IL13, var("NCIT:C121521")) increases p(HGNC:IL13) + + - pmid:21718217 + pubmed:28843454 - a(CHEBI:cholesterol) increases act(p(HGNC:NR1H3)) + p(HGNC:IL13) regulates bp(GO:"immune response") - pmid:19721446 + pubmed:28843454 - a(CHEBI:cholesterol) association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + p(HGNC:IL13) regulates bp(GO:"T cell differentiation") - pmid:29758300 + pubmed:30967783 - a(CHEBI:cholesterol) increases a(MESH:"Amyloid beta-Peptides") + p(HGNC:IL13) increases act(a(NCIT:C123783)) - pmid:29758300 + pubmed:30967783 - a(CHEBI:cholesterol) regulates act(complex(GO:"gamma-secretase complex")) + p(HGNC:IL13) decreases bp(GO:"inflammatory response") - pmid:22908190 + pubmed:28843454 - a(CHEBI:cholesterol) positiveCorrelation p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") + g(HGNC:IL17A, var("NCIT:C121521")) increases p(HGNC:IL17A) + + - pmid:22908190 + pubmed:28843454 - a(CHEBI:cholesterol) positiveCorrelation bp(GO:endocytosis) + p(HGNC:IL17A) regulates bp(GO:"immune response") - pmid:22908190 + pubmed:28843454 - a(CHEBI:cholesterol) increases a(GO:endosome) + p(HGNC:IL17A) regulates bp(GO:"T cell differentiation") - pmid:21718217 + pubmed:30988501 - p(HBP:HBP00030) association path(MESH:"Alzheimer Disease") + p(HGNC:IL17A) negativeCorrelation path(DOID:schizophrenia) - pmid:21718217 + pubmed:30988501 - p(HGNC:IL10) decreases a(MESH:Macrophages) + p(HGNC:IL17A) negativeCorrelation path(DOID:"mental depression") - pmid:21718217 + pubmed:30988501 - a(MESH:Glucocorticoids) decreases a(MESH:Macrophages) + p(HGNC:IL17A) negativeCorrelation path(DOID:"post-traumatic stress disorder") - pmid:28445721 + pubmed:30988501 - path(MESH:Motivation) association p(FPLX:CHRN) + p(HGNC:IL17A) increases path(HP:Autism) - pmid:30985105 + pubmed:28843454 - bp(GO:"dopamine secretion") association p(HGNC:SNCA) + g(HGNC:PTPN6) regulates a(MESH:"Immune System") - pmid:28445721 + pubmed:28843454 - bp(MESH:"Physiological Phenomena") association a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") + g(HGNC:PTPN6) decreases path(MESH:Inflammation) - pmid:28445721 + pubmed:28843454 - path(MESH:Disease) association a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") + p(HGNC:PTPN6, pmod(NCIT:C20102)) decreases g(HGNC:PTPN6) - pmid:28445721 + pubmed:28843454 - p(HGNC:RIC3) increases act(p(FPLX:CHRN)) + p(HGNC:PTPN6, pmod(NCIT:C20102)) increases path(MESH:Inflammation) + + + + - pmid:28445721 + pubmed:10887109 - p(HGNC:RIC3) increases act(p(FPLX:CHRN)) + p(HGNC:PTPN6) increases complex(p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation")), p(HGNC:PTPN6, pmod(go:0006468 ! "protein phosphorylation", Tyr))) - pmid:28445721 + pubmed:10887109 - p(HGNC:RIC3) increases act(p(FPLX:CHRN)) + p(HGNC:PTPN6) increases p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 340)) - pmid:22040696 + pubmed:10887109 - act(p(HGNC:RIC3), ma(chap)) increases p(FPLX:CHRN) + p(HGNC:PTPN6) increases p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 358)) + + + + - pmid:22040696 + pubmed:10887109 - p(HGNC:RIC3) increases act(p(FPLX:CHRN)) + p(HGNC:PTPN6) increases complex(p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation")), p(HGNC:PTPN6)) + + + + + + + + + + + + + + + + + + + + - pmid:22040696 + pubmed:28843454 - act(p(HGNC:RIC3), ma(chap)) increases p(FPLX:CHRN) + p(MESH:"Herpesvirus 1, Human") decreases p(HGNC:HLA-DRB1) - pmid:28445721 + pubmed:28843454 - p(HGNC:RIC3) causesNoChange complex(a(CHEBI:epibatidine), a(MESH:"nicotinic receptor alpha3beta2")) + p(NCIT:C150640) increases path(DOID:"multiple sclerosis") - pmid:28445721 + pubmed:28843454 - p(HGNC:RIC3) causesNoChange complex(a(CHEBI:epibatidine), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + p(NCIT:C150640) increases path(DOID:"multiple sclerosis") - pmid:28445721 + pubmed:28843454 - p(HGNC:RIC3) increases surf(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + a(PUBCHEM:107970) decreases path(EFO:"relapsing-remitting multiple sclerosis") - pmid:22040696 + pubmed:28843454 - p(HGNC:RIC3) increases bp(GO:"synaptic transmission, cholinergic") + a(PUBCHEM:107970) decreases path(ORPHANET:477738) - pmid:22040696 + pubmed:28843454 - p(HGNC:RIC3) decreases act(complex(p(HGNC:CHRNA3), p(HGNC:CHRNB4))) + a(PUBCHEM:107970) isA path(MESH:"Administration, Oral") - pmid:22040696 + pubmed:27956442 - p(HGNC:RIC3) decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) + a(PUBCHEM:107970) increases path(MESH:"Leukoencephalopathy, Progressive Multifocal") - pmid:22040696 + pubmed:27956442 - p(HGNC:RIC3) increases p(HGNC:CHRNA9) + a(PUBCHEM:107970) increases path(MESH:Cough) - pmid:22040696 + pubmed:27956442 - p(HGNC:RIC3) increases p(HGNC:CHRNA7) + a(PUBCHEM:107970) increases path(MESH:Headache) - pmid:22040696 + pubmed:27956442 - act(p(HGNC:RIC3), ma(chap)) negativeCorrelation path(MESH:"Bipolar Disorder") + a(PUBCHEM:107970) increases path(MESH:"Back Pain") - pmid:22040696 + pubmed:27956442 - act(p(HGNC:RIC3), ma(chap)) negativeCorrelation path(MESH:"Psychotic Disorders") + a(PUBCHEM:107970) increases path(MESH:Diarrhea) - pmid:28445721 + pubmed:27956442 - p(HGNC:TMEM35A) regulates act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + a(PUBCHEM:107970) increases path(MESH:Infection) - pmid:28445721 + pubmed:27956442 - act(p(HGNC:TMEM35A), ma(chap)) regulates surf(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + a(PUBCHEM:107970) increases path(MESH:"Liver Diseases") - pmid:28445721 + pubmed:27956442 - act(p(HGNC:TMEM35A), ma(chap)) regulates a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") + a(PUBCHEM:107970) increases path(MESH:Lymphopenia) - pmid:28445721 + pubmed:27956442 - act(p(HGNC:TMEM35A), ma(chap)) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + a(PUBCHEM:107970) increases path(MESH:"Macular Edema") - pmid:28445721 + pubmed:28843454 - act(p(HGNC:TMEM35A), ma(chap)) increases surf(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + a(PUBCHEM:54684141) decreases path(EFO:"relapsing-remitting multiple sclerosis") - pmid:28445721 + pubmed:28843454 - act(p(HGNC:TMEM35A), ma(chap)) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") + a(PUBCHEM:54684141) decreases path(ORPHANET:477738) - pmid:28445721 + pubmed:28843454 - act(p(HGNC:TMEM35A), ma(chap)) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") + a(PUBCHEM:54684141) isA path(MESH:"Administration, Oral") - pmid:28445721 + pubmed:27956442 - act(p(HGNC:TMEM35A), ma(chap)) increases surf(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + a(PUBCHEM:54684141) increases path(MESH:"Liver Diseases") - pmid:28445721 + pubmed:27956442 - p(HGNC:TMEM35A) causesNoChange act(p(FPLX:GABR)) + a(PUBCHEM:54684141) increases path(MESH:Diarrhea) - pmid:28445721 + pubmed:27956442 - p(HGNC:TMEM35A) causesNoChange act(a(MESH:"Receptors, Serotonin")) + a(PUBCHEM:54684141) increases path(MESH:Alopecia) - pmid:28445721 + pubmed:28843454 - p(HGNC:TMEM35A) causesNoChange act(p(HGNC:TRPV1)) + a(PUBCHEM:637568) decreases path(EFO:"relapsing-remitting multiple sclerosis") - pmid:28445721 + pubmed:28843454 - p(HGNC:TMEM35A) causesNoChange act(a(MESH:"Receptors, Glutamate")) + a(PUBCHEM:637568) decreases path(ORPHANET:477738) - pmid:28445721 + pubmed:28843454 - act(p(HGNC:TMEM35A), ma(chap)) increases act(a(HBP:HBP00174)) + a(PUBCHEM:637568) isA path(MESH:"Administration, Oral") - pmid:28445721 + pubmed:27794524 - act(p(HGNC:TMEM35A), ma(chap)) increases surf(a(HBP:HBP00174)) + a(PUBCHEM:637568) increases p(HGNC:NFE2L2) - pmid:28445721 + pubmed:27956442 - act(p(HGNC:TMEM35A), ma(chap)) increases a(HBP:HBP00174) + a(PUBCHEM:637568) increases path(MESH:"Leukoencephalopathy, Progressive Multifocal") - pmid:28445721 + pubmed:27956442 - act(p(HGNC:TMEM35A), ma(chap)) increases act(a(MESH:"nicotinic receptor alpha3beta2")) + a(PUBCHEM:637568) increases path(MESH:Flushing) - pmid:28445721 + pubmed:27956442 - act(p(HGNC:TMEM35A), ma(chap)) increases surf(a(MESH:"nicotinic receptor alpha3beta2")) + a(PUBCHEM:637568) increases path(MESH:"Gastrointestinal Diseases") - pmid:28445721 + pubmed:27956442 - act(p(HGNC:TMEM35A), ma(chap)) increases a(MESH:"nicotinic receptor alpha3beta2") + a(PUBCHEM:637568) increases path(MESH:Lymphopenia) - pmid:28445721 + pubmed:27956442 - act(p(HGNC:TMEM35A), ma(chap)) increases act(a(MESH:"nicotinic receptor alpha3beta4")) + a(PUBCHEM:637568) increases path(MESH:Exanthema) - pmid:28445721 + pubmed:27956442 - act(p(HGNC:TMEM35A), ma(chap)) increases surf(a(MESH:"nicotinic receptor alpha3beta4")) + a(PUBCHEM:637568) increases path(MESH:Ketosis) - pmid:28445721 + pubmed:27956442 - act(p(HGNC:TMEM35A), ma(chap)) increases a(MESH:"nicotinic receptor alpha3beta4") + a(PUBCHEM:637568) increases path(MESH:Proteinuria) - pmid:28445721 + pubmed:27956442 - act(p(HGNC:TMEM35A), ma(chap)) increases complex(a(CHEBI:epibatidine), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + a(PUBCHEM:637568) increases path(MESH:"Liver Diseases") - pmid:28445721 + pubmed:28843454 - act(p(HGNC:TMEM35A), ma(chap)) increases complex(a(CHEBI:epibatidine), a(MESH:"nicotinic receptor alpha3beta2")) + a(PUBCHEM:135341754) decreases path(ORPHANET:477738) - pmid:28445721 + pubmed:28843454 - act(p(HGNC:TMEM35A), ma(chap)) increases complex(a(CHEBI:epibatidine), a(HBP:HBP00174)) + a(PUBCHEM:135341754) isA path(MESH:"Home Infusion Therapy") - pmid:28445721 + pubmed:28843454 - act(p(HGNC:TMEM35A), ma(chap)) increases complex(a(CHEBI:epibatidine), a(MESH:"nicotinic receptor alpha3beta4")) + a(PUBCHEM:2907) decreases path(ORPHANET:477738) - pmid:28445721 + pubmed:28843454 - p(HGNC:TMEM35A) increases complex(a(CHEBI:epibatidine), a(MESH:"alpha6beta2 nicotinic acetylcholine receptor")) + a(PUBCHEM:2907) isA path(MESH:"Home Infusion Therapy") - pmid:28445721 + pubmed:28843454 - p(HGNC:TMEM35A) increases complex(a(CHEBI:epibatidine), a(MESH:"alpha6beta2 nicotinic acetylcholine receptor")) + a(PUBCHEM:135330159) decreases path(ORPHANET:477738) - pmid:28445721 + pubmed:28843454 - p(HGNC:TMEM35A) increases a(MESH:"alpha6beta2 nicotinic acetylcholine receptor") + a(PUBCHEM:135330159) isA path(MESH:"Home Infusion Therapy") - pmid:28445721 + pubmed:27956442 - act(p(MGI:Tmem35a), ma(chap)) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") + a(PUBCHEM:135330159) increases path(NCIT:C78251) - pmid:28445721 + pubmed:27956442 - p(MGI:Tmem35a) association p(MGI:Canx) + a(PUBCHEM:135330159) increases path(MESH:Headache) - pmid:28445721 + pubmed:27956442 - p(MGI:Tmem35a) increases complex(a(MESH:Bungarotoxins), p(FPLX:CHRN)) + a(PUBCHEM:135330159) increases path(MESH:Exanthema) - pmid:28445721 + pubmed:27956442 - p(MGI:Tmem35a) increases complex(a(CHEBI:epibatidine), a(HBP:HBP00180)) + a(PUBCHEM:135330159) increases path(MESH:Fever) - pmid:28445721 + pubmed:27956442 - p(MGI:Tmem35a) increases complex(a(CHEBI:epibatidine), a(HBP:HBP00174)) + a(PUBCHEM:135330159) increases path(MESH:Nausea) - pmid:28445721 + pubmed:27956442 - p(MGI:Tmem35a) increases a(HBP:HBP00180) + a(PUBCHEM:135330159) increases path(MESH:Diarrhea) - pmid:28445721 + pubmed:27956442 - p(MGI:Tmem35a) increases complex(a(MESH:Bungarotoxins), loc(GO:membrane)) + a(PUBCHEM:135330159) increases path(MESH:Hypotension) - pmid:28445721 + pubmed:27956442 - p(MGI:Tmem35a) increases p(FPLX:CHRN) + a(PUBCHEM:135330159) increases path(MESH:"Herpes Simplex") - pmid:28445721 + pubmed:27956442 - p(MGI:Tmem35a) regulates p(FPLX:CHRN) + a(PUBCHEM:135330159) increases path(MESH:"POEMS Syndrome") - pmid:28445721 + pubmed:28843454 - p(MGI:Tmem35a) increases a(MESH:"nicotinic receptor alpha3beta4") + a(PUBCHEM:46504469) decreases path(ORPHANET:477738) - pmid:28445721 + pubmed:28843454 - p(MGI:Tmem35a) decreases bp(GO:locomotion) + a(PUBCHEM:46504469) isA p(MESH:"Antibodies, Monoclonal") - pmid:28445721 + pubmed:28843454 - p(MGI:Tmem35a) decreases bp(GO:locomotion) + path(DOID:"mental depression") association path(ORPHANET:477738) - pmid:28445721 + pubmed:28843454 - p(MGI:Tmem35a) association bp(GO:"temperature homeostasis") + path(DOID:"mental depression") association path(DOID:"multiple sclerosis") - pmid:28445721 + pubmed:26979166 - p(MGI:Tmem35a) increases bp(GO:learning) + path(DOID:"mental depression") directlyIncreases act(a(MESH:Phagocytes)) - pmid:28445721 + pubmed:30988501 - p(MGI:Tmem35a) increases bp(GO:memory) + path(DOID:"mental depression") negativeCorrelation p(HGNC:IL6) - pmid:28445721 + pubmed:30988501 - p(MGI:Tmem35a) increases path(MESH:"Spatial Learning") + path(DOID:"mental depression") negativeCorrelation p(HGNC:IL2) - pmid:28445721 + pubmed:30988501 - p(MGI:Tmem35a) increases path(MESH:"Spatial Memory") + path(DOID:"mental depression") negativeCorrelation p(HGNC:IL1B) - - - - - - - - - pmid:11230871 + pubmed:30988501 - complex(a(CHEBI:epibatidine), p(FPLX:CHRN)) negativeCorrelation bp(GO:aging) + path(DOID:"mental depression") negativeCorrelation p(HGNC:IL17A) - pmid:11230871 + pubmed:30988501 - complex(a(CHEBI:epibatidine), p(FPLX:CHRN)) negativeCorrelation bp(GO:aging) + path(DOID:"mental depression") negativeCorrelation p(HGNC:CRP) - - - - - - - - - - - - - - - - - - - - - pmid:28445721 + pubmed:30988501 - composite(p(HGNC:RIC3), p(HGNC:TMEM35A)) increases complex(a(CHEBI:epibatidine), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + path(DOID:"mental depression") increases deg(a(MESH:Microglia)) - pmid:28445721 + pubmed:30988501 - composite(p(HGNC:RIC3), p(HGNC:TMEM35A)) increases complex(a(CHEBI:epibatidine), a(MESH:"nicotinic receptor alpha3beta2")) + path(DOID:"mental depression") increases a(MESH:Microglia) - - - - - pmid:28445721 + pubmed:30988501 - composite(a(MESH:Bungarotoxins), p(HGNC:TMEM35A)) decreases complex(a(CHEBI:epibatidine), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + path(DOID:"mental depression") negativeCorrelation a(PUBCHEM:135305802) - pmid:28445721 + pubmed:28843454 - p(MGI:Canx) association p(MGI:Tmem35a) + path(MESH:Fatigue) association path(ORPHANET:477738) - - - - - pmid:28445721 + pubmed:28843454 - composite(a(CHEBI:nicotine), p(HGNC:TMEM35A)) increases a(HBP:HBP00174) + path(MESH:Fatigue) association path(DOID:"multiple sclerosis") - - - - - pmid:18174175 + pubmed:18986241 - complex(a(CHEBI:epibatidine), a(MESH:"alpha6beta2 nicotinic acetylcholine receptor")) increases act(a(MESH:"alpha6beta2 nicotinic acetylcholine receptor")) + path(MESH:Fatigue) association a(MESH:"Cholinesterase Inhibitors") - pmid:21787755 + pubmed:28843454 - a(MESH:"alpha6beta2 nicotinic acetylcholine receptor") regulates sec(a(CHEBI:"gamma-aminobutyric acid")) + path(DOID:"cognitive disorder") association path(ORPHANET:477738) - pmid:28445721 + pubmed:28843454 - a(MESH:"alpha-conotoxin MII") decreases complex(a(CHEBI:epibatidine), a(MESH:"alpha6beta2 nicotinic acetylcholine receptor")) + path(DOID:"cognitive disorder") association path(DOID:"multiple sclerosis") - pmid:21787755 + pubmed:30988501 - a(MESH:"alpha-conotoxin MII") decreases act(a(HBP:"alpha-3 beta-2 nAChR")) + p(HGNC:IFNB1) decreases path(MESH:"Multiple Sclerosis, Relapsing-Remitting") - - - - - - - - - - - pmid:28445721 + pubmed:30988501 - bp(GO:"temperature homeostasis") association p(MGI:Tmem35a) + p(HGNC:IFNB1) isA a(CHEBI:"anti-inflammatory agent") - - - - - pmid:21482353 + pubmed:30988501 - a(MESH:"Presynaptic Terminals") increases tloc(a(CHEBI:acetylcholine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) + p(HGNC:IFNB1) increases path(NCIT:C78302) - pmid:27671637 + pubmed:30988501 - a(MESH:"Presynaptic Terminals") causesNoChange p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) + p(HGNC:IFNB1) decreases path(DOID:"secondary progressive multiple sclerosis") - pmid:21482353 + pubmed:26445701 - p(HGNC:CHRNA4, var("?")) positiveCorrelation path(MESH:Epilepsy) + p(HGNC:IFNB1) decreases tloc(a(MESH:T-Lymphocytes), fromLoc(MESH:"Peripheral Nervous System"), toLoc(MESH:"Central Nervous System")) - pmid:21482353 + pubmed:26445701 - p(HGNC:CHRNA4, var("?")) increases path(HBP:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") + p(HGNC:IFNB1) regulates act(a(MESH:T-Lymphocytes)) - pmid:21482353 + pubmed:30967783 - p(HGNC:CHRNB2, var("?")) positiveCorrelation path(MESH:Epilepsy) + p(HGNC:IFNB1) regulates a(MESH:T-Lymphocytes) - pmid:21482353 + pubmed:26445701 - p(HGNC:CHRNB2, var("?")) increases path(HBP:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") + p(HGNC:IFNB1) association a(MESH:"Blood-Brain Barrier") - pmid:21482353 + pubmed:26445701 - p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:"Tobacco Use Disorder") + p(HGNC:IFNB1) regulates act(a(MESH:B-Lymphocytes)) - pmid:21482353 + pubmed:30967783 - p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:"Tobacco Use Disorder") + p(HGNC:IFNB1) regulates a(MESH:B-Lymphocytes) - pmid:21482353 + pubmed:26445701 - p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:Alcoholism) + p(HGNC:IFNB1) regulates bp(GO:"B cell cytokine production") - pmid:21482353 + pubmed:26445701 - p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:"Cocaine-Related Disorders") + p(HGNC:IFNB1) regulates bp(GO:"T cell cytokine production") - pmid:21482353 + pubmed:26445701 - p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:"Opioid-Related Disorders") + p(HGNC:IFNB1) decreases path(DOID:"relapsing-remitting multiple sclerosis") - pmid:21482353 + pubmed:26445701 - p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:"Lung Neoplasms") + p(HGNC:IFNB1) increases path(DOID:"mental depression") - pmid:21482353 + pubmed:30988501 - p(HGNC:CHRNA5, var("?")) positiveCorrelation bp(GO:cognition) + p(HGNC:IFNB1) increases path(DOID:"mental depression") - - - pmid:21482353 + pubmed:26445701 - complex(p(FPLX:CHRN), p(HGNC:RIC3)) increases p(FPLX:CHRN) + p(HGNC:IFNB1) increases p(MESH:Enzymes) - pmid:21482353 + pubmed:26445701 - complex(p(FPLX:CHRN), p(HGNC:RIC3)) increases act(p(FPLX:CHRN)) + p(HGNC:IFNB1) increases path(DOID:"thyroid gland disease") - - - - - - - pmid:21482353 + pubmed:26445701 - complex(a(INTERPRO:"14-3-3 protein"), p(FPLX:CHRN)) increases p(FPLX:CHRN) + p(HGNC:IFNB1) increases path(DOID:leukopenia) - pmid:21482353 + pubmed:26445701 - complex(a(INTERPRO:"14-3-3 protein"), p(FPLX:CHRN)) increases act(p(FPLX:CHRN)) + p(HGNC:IFNB1) increases path(MESH:"Injection Site Reaction") - - - pmid:21482353 + pubmed:30967783 - complex(p(FPLX:CHRN), p(INTERPRO:Neurexin)) increases p(FPLX:CHRN) + p(HGNC:IFNB1) decreases path(DOID:"multiple sclerosis") - pmid:21482353 + pubmed:30988501 - complex(p(FPLX:CHRN), p(INTERPRO:Neurexin)) increases act(p(FPLX:CHRN)) + p(HGNC:IFNB1) biomarkerFor path(CONSO:neuroinflammation) - - - - - pmid:21482353 + pubmed:30988501 - complex(p(FPLX:CHRN), p(HGNC:VSNL1)) increases p(FPLX:CHRN) + p(HGNC:IFNB1) biomarkerFor path(CONSO:Neurodegeneration) - pmid:21482353 + pubmed:30988501 - complex(p(FPLX:CHRN), p(HGNC:VSNL1)) increases act(p(FPLX:CHRN)) + path(MESH:"Multiple Sclerosis, Relapsing-Remitting") decreases bp(MESH:"Adaptive Immunity") - - - pmid:19721446 + pubmed:30988501 - p(HGNC:VSNL1) association p(HGNC:CHRNA4, frag("331_600")) + path(MESH:"Multiple Sclerosis, Relapsing-Remitting") increases path(MESH:Inflammation) - - - pmid:21482353 + pubmed:27794524 - complex(p(FPLX:CHRN), p(HGNC:LYNX1)) regulates act(p(FPLX:CHRN)) + path(MESH:"Multiple Sclerosis, Relapsing-Remitting") increases path(MESH:Inflammation) - pmid:21482353 + pubmed:27956442 - complex(p(FPLX:CHRN), p(HGNC:LYNX1)) association act(p(FPLX:CHRN)) + path(MESH:"Multiple Sclerosis, Relapsing-Remitting") association path(MESH:Inflammation) - pmid:21482353 + pubmed:27794524 - complex(p(FPLX:CHRN), p(HGNC:LYNX1)) association surf(p(FPLX:CHRN)) + path(MESH:"Multiple Sclerosis, Relapsing-Remitting") increases bp(GO:"inflammatory response") - - - pmid:21482353 + pubmed:27794524 - p(HGNC:LYNX1) regulates act(p(FPLX:CHRN)) + path(MESH:"Multiple Sclerosis, Relapsing-Remitting") increases path(CONSO:"Clonal Expansion") - pmid:21482353 + pubmed:27794524 - p(HGNC:LYNX1) decreases act(p(FPLX:CHRN)) + path(MESH:"Multiple Sclerosis, Relapsing-Remitting") causesNoChange path(MESH:Meningitis) - pmid:21482353 + pubmed:27794524 - p(HGNC:LYNX1) decreases act(p(FPLX:CHRN)) + path(MESH:"Multiple Sclerosis, Relapsing-Remitting") causesNoChange path(MESH:Pathology) - pmid:21482353 + pubmed:27794524 - p(HGNC:LYNX1) regulates act(p(FPLX:CHRN)) + path(MESH:"Multiple Sclerosis, Relapsing-Remitting") directlyDecreases a(PUBCHEM:65065) - pmid:21482353 + pubmed:27956442 - p(HGNC:LYNX1) decreases bp(GO:"synaptic transmission, cholinergic") + path(MESH:"Multiple Sclerosis, Relapsing-Remitting") increases bp(GO:"transport across blood-brain barrier") - pmid:21482353 + pubmed:22020111 - p(HGNC:LYNX1) association bp(GO:"synaptic transmission, cholinergic") + path(MESH:"Multiple Sclerosis, Relapsing-Remitting") negativeCorrelation a(PUBCHEM:400769) - pmid:21482353 + pubmed:22020111 - p(HGNC:LYNX1) association path(MESH:"Cognitive Dysfunction") + path(MESH:"Multiple Sclerosis, Relapsing-Remitting") negativeCorrelation act(p(HGNC:NFE2L2)) - pmid:21482353 + pubmed:30988501 - p(HGNC:LYNX1) positiveCorrelation bp(GO:"neuron maturation") + a(MESH:"Glatiramer Acetate") increases path(MESH:"Injection Site Reaction") - pmid:21482353 + pubmed:26445701 - p(HGNC:LYNX1) negativeCorrelation bp(GO:"synapse maturation") + a(MESH:"Glatiramer Acetate") increases path(MESH:"Injection Site Reaction") - pmid:21482353 + pubmed:30988501 - p(HGNC:LYNX1) regulates bp(GO:"generation of neurons") + a(MESH:"Glatiramer Acetate") increases path(HP:Palpitations) - pmid:28901280 + pubmed:26445701 - p(HGNC:LYNX1) decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) + a(MESH:"Glatiramer Acetate") increases path(HP:Palpitations) - pmid:28901280 + pubmed:30988501 - p(HGNC:LYNX1) decreases act(p(HGNC:CHRNA7)) + a(MESH:"Glatiramer Acetate") increases path(HP:"Chest tightness") - + + + pubmed:26445701 + + a(MESH:"Glatiramer Acetate") increases path(HP:"Chest tightness") + - + + + pubmed:30988501 + + a(MESH:"Glatiramer Acetate") increases path(HP:Anxiety) + - pmid:21482353 + pubmed:26445701 - composite(a(HBP:"alpha-4 beta-2 nAChR"), p(HGNC:LYNX1)) decreases act(p(FPLX:CHRN)) + a(MESH:"Glatiramer Acetate") association p(HGNC:MBP) - - - pmid:21482353 + pubmed:26445701 - complex(a(HBP:"alpha-4 beta-2 nAChR"), p(HGNC:LYNX1)) regulates act(a(HBP:"alpha-4 beta-2 nAChR")) + a(MESH:"Glatiramer Acetate") decreases complex(a(GO:"myelin sheath"), a(MESH:T-Lymphocytes)) - - - pmid:21482353 + pubmed:26445701 - complex(p(HGNC:CHRNA3), p(HGNC:LYNX1)) regulates act(p(HGNC:CHRNA3)) + a(MESH:"Glatiramer Acetate") increases complex(a(MESH:"Glatiramer Acetate"), a(MESH:T-Lymphocytes)) - - - - - pmid:21482353 + pubmed:26445701 - complex(a(HBP:"alpha-7-containing nAChR"), p(HGNC:LYNX1)) regulates act(a(HBP:"alpha-7-containing nAChR")) + a(MESH:"Glatiramer Acetate") increases bp(GO:"T-helper 2 cell cytokine production") - - - pmid:21482353 + pubmed:26445701 - a(HBP:"alpha-7-containing nAChR") increases p(HGNC:SLC12A5) + a(MESH:"Glatiramer Acetate") increases path(HP:Flushing) - pmid:21482353 + pubmed:26445701 - a(HBP:"alpha-7-containing nAChR") increases p(HGNC:SLC12A5) + a(MESH:"Glatiramer Acetate") increases path(HP:Dyspnea) - pmid:21482353 + pubmed:26445701 - a(HBP:"alpha-7-containing nAChR") association bp(GO:"macrophage activation") + a(MESH:"Glatiramer Acetate") increases path(HP:Lipoatrophy) - pmid:21482353 + pubmed:30967783 - a(HBP:"alpha-7-containing nAChR") association bp(GO:"response to cytokine") + a(MESH:"Glatiramer Acetate") decreases path(DOID:"multiple sclerosis") - pmid:11230871 + pubmed:30967783 - a(HBP:"alpha-7-containing nAChR") negativeCorrelation path(MESH:Schizophrenia) + a(MESH:"Glatiramer Acetate") regulates a(MESH:T-Lymphocytes) - pmid:11230871 + pubmed:30967783 - a(HBP:"alpha-7-containing nAChR") regulates act(a(CHEBI:"amyloid-beta")) + a(MESH:"Glatiramer Acetate") regulates a(MESH:B-Lymphocytes) - pmid:21787755 + pubmed:30967783 - a(HBP:"alpha-7-containing nAChR") decreases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + a(MESH:"Glatiramer Acetate") increases bp(MESH:Neuroprotection) - pmid:21787755 + pubmed:30988501 - a(HBP:"alpha-7-containing nAChR") regulates bp(GO:"excitatory chemical synaptic transmission") + a(DRUGBANK:Leflunomide) increases a(DRUGBANK:Teriflunomide) - pmid:21787755 + pubmed:30988501 - a(HBP:"alpha-7-containing nAChR") association bp(GO:"neurotransmitter secretion") + a(DRUGBANK:Leflunomide) isA a(CHEBI:"EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitor") - pmid:21787755 + pubmed:30988501 - a(HBP:"alpha-7-containing nAChR") association bp(GO:"maintenance of synapse structure") + a(DRUGBANK:Leflunomide) decreases bp(MESH:"Cell Proliferation") - pmid:21787755 + pubmed:30988501 - a(HBP:"alpha-7-containing nAChR") association bp(GO:"neuron projection maintenance") + a(DRUGBANK:Teriflunomide) increases bp(MESH:Immunomodulation) - pmid:21787755 + pubmed:30988501 - a(HBP:"alpha-7-containing nAChR") association bp(GO:"long-term synaptic potentiation") + a(DRUGBANK:Teriflunomide) increases bp(MESH:"Immunoglobulin Class Switching") - pmid:21787755 + pubmed:30988501 - a(HBP:"alpha-7-containing nAChR") association path(MESH:Seizures) + a(DRUGBANK:Teriflunomide) increases path(HP:Headache) - pmid:21787755 + pubmed:30988501 - a(HBP:"alpha-7-containing nAChR") association bp(GO:"neuron death") + a(DRUGBANK:Teriflunomide) increases p(MESH:Enzymes, loc(MESH:Liver)) - pmid:21482353 + pubmed:30988501 - p(MGI:Lynx1) decreases a(CHEBI:"calcium(2+)") + a(DRUGBANK:Teriflunomide) increases path(MESH:Diarrhea) - pmid:21482353 + pubmed:30988501 - p(MGI:Lynx1) decreases bp(MESH:"Synaptic Transmission") + a(DRUGBANK:Teriflunomide) increases path(MESH:Alopecia) - pmid:21482353 + pubmed:30988501 - p(MGI:Lynx1) decreases bp(GO:learning) + a(DRUGBANK:Teriflunomide) increases path(MESH:Nausea) - pmid:21482353 + pubmed:18986241 - p(MGI:Lynx1) decreases bp(GO:memory) + path(MESH:Diarrhea) association a(MESH:"Cholinesterase Inhibitors") - pmid:21482353 + pubmed:18986241 - p(MGI:Lynx1) decreases bp(MESH:"Dominance, Ocular") + path(MESH:Nausea) association a(MESH:"Cholinesterase Inhibitors") - pmid:21482353 + pubmed:19721446 - p(MGI:Lynx1) decreases bp(GO:"synaptic transmission, cholinergic") + path(MESH:Nausea) association a(MESH:"5-(2-azetidinylmethoxy)-2-chloropyridine") - pmid:21482353 + pubmed:30988501 - p(MGI:Lynx1) increases a(MESH:Neurons) + a(CHEBI:"dimethyl fumarate") increases act(p(HGNC:NFE2L2)) - pmid:21482353 + pubmed:26445701 - act(a(MESH:Brain)) negativeCorrelation act(p(FPLX:CHRN)) + a(CHEBI:"dimethyl fumarate") increases act(p(HGNC:NFE2L2)) - pmid:22299660 + pubmed:22020111 - a(MESH:Brain) association p(HGNC:PPP2R2A) + a(CHEBI:"dimethyl fumarate") increases act(p(HGNC:NFE2L2)) - pmid:21482353 + pubmed:22020111 - p(MGI:Slc12a2) increases act(p(MGI:Lynx1)) + a(CHEBI:"dimethyl fumarate") increases act(p(HGNC:NFE2L2)) - pmid:21482353 + pubmed:22020111 - p(FPLX:ADCY, var("?")) decreases act(p(MGI:Lynx1)) + a(CHEBI:"dimethyl fumarate") increases act(p(HGNC:NFE2L2)) - pmid:21482353 + pubmed:22020111 - p(HGNC:PSCA) decreases bp(GO:"programmed cell death") + a(CHEBI:"dimethyl fumarate") causesNoChange act(p(HGNC:NFE2L2)) - pmid:21482353 + pubmed:22020111 - bp(GO:"neuron maturation") positiveCorrelation p(HGNC:LYNX1) + a(CHEBI:"dimethyl fumarate") increases act(p(HGNC:NFE2L2)) - pmid:21482353 + pubmed:30988501 - bp(GO:"synapse maturation") negativeCorrelation p(HGNC:LYNX1) + a(CHEBI:"dimethyl fumarate") isA a(CHEBI:antioxidant) - pmid:21482353 + pubmed:30988501 - bp(GO:"GABAergic neuron differentiation") association path(MESH:Schizophrenia) + a(CHEBI:"dimethyl fumarate") decreases p(HGNC:NFKB1) - pmid:21482353 + pubmed:30988501 - bp(GO:"GABAergic neuron differentiation") association path(MESH:Amblyopia) + a(CHEBI:"dimethyl fumarate") decreases a(MESH:Cytokines) - pmid:21482353 + pubmed:30988501 - path(MESH:Amblyopia) association bp(GO:"GABAergic neuron differentiation") + a(CHEBI:"dimethyl fumarate") decreases path(MESH:Inflammation) - pmid:21482353 + pubmed:30988501 - a(HP:"inhibitory interneuron") regulates bp(GO:"sensory processing") + a(CHEBI:"dimethyl fumarate") increases path(MESH:Flushing) - pmid:21482353 + pubmed:30988501 - act(a(HP:"inhibitory interneuron")) increases act(p(FPLX:NOS)) + a(CHEBI:"dimethyl fumarate") increases path(MESH:"Gastrointestinal Diseases") - pmid:21482353 + pubmed:30988501 - a(HP:"inhibitory interneuron") association a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") + a(CHEBI:"dimethyl fumarate") increases path(DOID:"progressive multifocal leukoencephalopathy") - pmid:21482353 + pubmed:26445701 - act(a(HP:"inhibitory interneuron")) negativeCorrelation g(HGNC:CHRFAM7A, var("?")) + a(CHEBI:"dimethyl fumarate") increases path(DOID:"progressive multifocal leukoencephalopathy") - pmid:24563850 + pubmed:26445701 - act(p(FPLX:NOS)) increases a(CHEBI:radical) + a(CHEBI:"dimethyl fumarate") decreases path(DOID:"relapsing-remitting multiple sclerosis") - pmid:24563850 + pubmed:26445701 - act(p(FPLX:NOS)) increases a(CHEBI:"reactive oxygen species") + a(CHEBI:"dimethyl fumarate") decreases path(DOID:"multiple sclerosis") - pmid:24563850 + pubmed:26445701 - act(p(FPLX:NOS)) increases a(CHEBI:"reactive nitrogen species") + a(CHEBI:"dimethyl fumarate") increases path(HP:Nausea) - pmid:21482353 + pubmed:26445701 - a(MESH:"Brain Stem") regulates act(a(MESH:Hippocampus)) + a(CHEBI:"dimethyl fumarate") increases path(DOID:diarrhea) - pmid:21482353 + pubmed:26445701 - g(HGNC:CHRFAM7A, var("?")) association path(MESH:Schizophrenia) - - - - - - - pmid:21482353 - - g(HGNC:CHRFAM7A, var("?")) negativeCorrelation act(a(HP:"inhibitory interneuron")) + a(CHEBI:"dimethyl fumarate") increases path(HP:"Abdominal pain") @@ -83088,2717 +83768,2604 @@

Statements

- pmid:21482353 + pubmed:26445701 - a(HBP:"GTS-21") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + a(CHEBI:"dimethyl fumarate") increases path(HP:Flushing) - pmid:21482353 + pubmed:26445701 - a(HBP:"GTS-21") increases path(MESH:Attention) + a(CHEBI:"dimethyl fumarate") increases path(DOID:lymphopenia) - pmid:21482353 + pubmed:29121589 - a(HBP:"GTS-21") increases bp(GO:"sensory processing") + a(CHEBI:"dimethyl fumarate") increases p(FPLX:ERK, pmod(go:0006468 ! "protein phosphorylation")) - pmid:21482353 + pubmed:29121589 - a(HBP:"GTS-21") decreases path(MESH:Anhedonia) + a(CHEBI:"dimethyl fumarate") increases p(FPLX:p38, pmod(go:0006468 ! "protein phosphorylation")) - pmid:21482353 + pubmed:29121589 - a(HBP:"GTS-21") decreases path(MESH:Aphasia) + a(CHEBI:"dimethyl fumarate") positiveCorrelation p(FPLX:AKT, pmod(go:0006468 ! "protein phosphorylation", Ser, 473)) - pmid:21482353 + pubmed:29121589 - p(HGNC:SLC12A5) decreases a(CHEBI:chloride) + a(CHEBI:"dimethyl fumarate") increases p(MGI:Gsk3b, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) - pmid:21482353 + pubmed:29121589 - p(HGNC:SLC12A5) regulates act(a(CHEBI:"gamma-aminobutyric acid")) + a(CHEBI:"dimethyl fumarate") decreases act(p(MGI:Gsk3b)) - pmid:21482353 + pubmed:29121589 - p(HGNC:PEMT) increases a(CHEBI:phosphatidylcholine) + a(CHEBI:"dimethyl fumarate") decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation")) - - - pmid:21482353 + pubmed:29121589 - a(CHEBI:phosphatidylcholine) increases a(CHEBI:choline) + a(CHEBI:"dimethyl fumarate") decreases p(MGI:Dpysl2, pmod(go:0006468 ! "protein phosphorylation")) - pmid:21482353 + pubmed:29121589 - p(HGNC:PEMT, var("?")) association path(MESH:"Choline Deficiency") + a(CHEBI:"dimethyl fumarate") decreases path(CONSO:Astrogliosis) - pmid:21482353 + pubmed:29121589 - p(HGNC:PEMT, var("?")) association path(MESH:Schizophrenia) + a(CHEBI:"dimethyl fumarate") decreases path(CONSO:Microgliosis) - pmid:21482353 + pubmed:29121589 - path(MESH:"Choline Deficiency") association p(HGNC:PEMT, var("?")) + a(CHEBI:"dimethyl fumarate") decreases r(MGI:Il1b) - pmid:21482353 + pubmed:29121589 - bp(GO:"macrophage activation") association a(HBP:"alpha-7-containing nAChR") + a(CHEBI:"dimethyl fumarate") decreases r(MGI:Nos2) - pmid:21482353 + pubmed:29121589 - bp(GO:"response to cytokine") association a(HBP:"alpha-7-containing nAChR") + a(CHEBI:"dimethyl fumarate") decreases bp(GO:"inflammatory response") - pmid:21482353 + pubmed:30988501 - bp(MESH:"Stress, Physiological") increases a(CHEBI:dopamine) + complex(a(DRUGBANK:Fingolimod), p(HGNCGENEFAMILY:"Sphingosine 1-phosphate receptors")) decreases p(HGNCGENEFAMILY:"Sphingosine 1-phosphate receptors") - pmid:23746257 + pubmed:30988501 - bp(MESH:"Stress, Physiological") increases a(MESH:"Heat-Shock Proteins") + complex(a(DRUGBANK:Fingolimod), p(HGNCGENEFAMILY:"Sphingosine 1-phosphate receptors")) increases deg(p(HGNCGENEFAMILY:"Sphingosine 1-phosphate receptors")) - pmid:25784053 + pubmed:27889190 - bp(MESH:"Stress, Physiological") regulates bp(HBP:Proteostasis) + complex(a(DRUGBANK:Fingolimod), p(HGNCGENEFAMILY:"Sphingosine 1-phosphate receptors")) association path(DOID:"relapsing-remitting multiple sclerosis") + + - pmid:21482353 + pubmed:30988501 - path(MESH:Fear) increases a(CHEBI:dopamine) + a(DRUGBANK:Fingolimod) decreases path(MESH:Recurrence) - pmid:21482353 + pubmed:27889190 - path(MESH:Alcoholism) positiveCorrelation p(HGNC:CHRNA5, var("?")) + a(DRUGBANK:Fingolimod) decreases path(MESH:Recurrence) - pmid:21482353 + pubmed:30988501 - path(MESH:Alcoholism) positiveCorrelation p(HGNC:CHRNA3, var("?")) + a(DRUGBANK:Fingolimod) increases path(HP:Bradycardia) - pmid:21482353 + pubmed:30988501 - path(MESH:Alcoholism) positiveCorrelation p(HGNC:CHRNB4, var("?")) + a(DRUGBANK:Fingolimod) increases path(MESH:"Atrioventricular Block") - pmid:21482353 + pubmed:30988501 - path(MESH:"Cocaine-Related Disorders") positiveCorrelation p(HGNC:CHRNA5, var("?")) + a(DRUGBANK:Fingolimod) increases path(MESH:"Macular Edema") - pmid:21482353 + pubmed:30988501 - path(MESH:"Cocaine-Related Disorders") positiveCorrelation p(HGNC:CHRNA3, var("?")) + a(DRUGBANK:Fingolimod) increases path(MESH:"Liver Function Tests") - pmid:21482353 + pubmed:30988501 - path(MESH:"Cocaine-Related Disorders") positiveCorrelation p(HGNC:CHRNB4, var("?")) + a(DRUGBANK:Fingolimod) increases path(MESH:Infection) - pmid:21482353 + pubmed:30988501 - path(MESH:"Opioid-Related Disorders") positiveCorrelation p(HGNC:CHRNA5, var("?")) + a(DRUGBANK:Fingolimod) increases path(HP:"Herpes simplex encephalitis") - pmid:21482353 + pubmed:30988501 - path(MESH:"Opioid-Related Disorders") positiveCorrelation p(HGNC:CHRNA3, var("?")) + a(DRUGBANK:Fingolimod) increases path(HP:"Severe varicella zoster infection") - pmid:21482353 + pubmed:27889190 - path(MESH:"Opioid-Related Disorders") positiveCorrelation p(HGNC:CHRNB4, var("?")) + a(DRUGBANK:Fingolimod) decreases path(NCIT:C3824) + + - pmid:21482353 + pubmed:19721446 - path(MESH:"Lung Neoplasms") positiveCorrelation p(HGNC:CHRNA5, var("?")) + path(MESH:Recurrence) association p(HGNC:CHRNA3) - pmid:21482353 + pubmed:19721446 - path(MESH:"Lung Neoplasms") positiveCorrelation p(HGNC:CHRNA3, var("?")) + path(MESH:Recurrence) association p(HGNC:CHRNB4) - pmid:21482353 + pubmed:30988501 - path(MESH:"Lung Neoplasms") positiveCorrelation p(HGNC:CHRNB4, var("?")) + path(HP:"Herpes simplex encephalitis") decreases bp(GO:"learning or memory") - pmid:19721446 + pubmed:30988501 - path(MESH:"Lung Neoplasms") association g(HGNC:CHRNA5) + path(HP:"Herpes simplex encephalitis") increases path(HP:"Brain atrophy") - pmid:19721446 + pubmed:30988501 - path(MESH:"Lung Neoplasms") association g(HGNC:CHRNA3) + path(HP:"Herpes simplex encephalitis") increases complex(a(MESH:Autoantibodies), a(MESH:Neuropil)) - pmid:19721446 + pubmed:30988501 - path(MESH:"Lung Neoplasms") association g(HGNC:CHRNB4) + a(DRUGBANK:Natalizumab) increases path(MESH:"Opportunistic Infections") - pmid:28901280 + pubmed:30988501 - path(MESH:"Lung Neoplasms") association g(DNSNP:rs1051730) + a(DRUGBANK:Natalizumab) increases path(DOID:"progressive multifocal leukoencephalopathy") - pmid:28901280 + pubmed:26445701 - path(MESH:"Lung Neoplasms") increases p(HGNC:CHRNA9) + a(DRUGBANK:Natalizumab) increases path(DOID:"progressive multifocal leukoencephalopathy") - pmid:28901280 + pubmed:30988501 - path(MESH:"Lung Neoplasms") increases p(HGNC:CHRNA5) + a(DRUGBANK:Natalizumab) increases path(MESH:"Meningitis, Cryptococcal") - pmid:28901280 + pubmed:30988501 - path(MESH:"Lung Neoplasms") increases p(HGNC:CHRNA10) + a(DRUGBANK:Natalizumab) isA p(MESH:"Antibodies, Monoclonal") - pmid:21482353 + pubmed:30988501 - p(HGNC:CHRNA3, var("?")) positiveCorrelation path(MESH:"Tobacco Use Disorder") + a(DRUGBANK:Natalizumab) decreases p(HGNC:ITGA4) - pmid:21482353 + pubmed:30988501 - p(HGNC:CHRNA3, var("?")) positiveCorrelation path(MESH:Alcoholism) + a(DRUGBANK:Natalizumab) decreases complex(p(HGNC:VCAM1), p(MESH:"Receptors, Very Late Antigen")) - pmid:21482353 + pubmed:30988501 - p(HGNC:CHRNA3, var("?")) positiveCorrelation path(MESH:"Cocaine-Related Disorders") + a(DRUGBANK:Natalizumab) decreases tloc(a(MESH:Lymphocytes), fromLoc(MESH:Blood), toLoc(MESH:Brain)) - pmid:21482353 + pubmed:26445701 - p(HGNC:CHRNA3, var("?")) positiveCorrelation path(MESH:"Opioid-Related Disorders") + a(DRUGBANK:Natalizumab) isA p(MESH:"Antibodies, Monoclonal, Humanized") + + - pmid:21482353 + pubmed:30967783 - p(HGNC:CHRNA3, var("?")) positiveCorrelation path(MESH:"Lung Neoplasms") + a(DRUGBANK:Natalizumab) decreases path(DOID:"multiple sclerosis") - pmid:21482353 + pubmed:30967783 - p(HGNC:CHRNA3, var("?")) positiveCorrelation bp(GO:cognition) + a(DRUGBANK:Natalizumab) regulates a(MESH:T-Lymphocytes) - pmid:21482353 + pubmed:30967783 - p(HGNC:CHRNB4, var("?")) positiveCorrelation path(MESH:"Tobacco Use Disorder") + a(DRUGBANK:Natalizumab) regulates a(MESH:B-Lymphocytes) - pmid:21482353 + pubmed:27956442 - p(HGNC:CHRNB4, var("?")) positiveCorrelation path(MESH:Alcoholism) + p(HGNC:ITGA4) isA a(MESH:"Cell Adhesion Molecules") - - - pmid:21482353 - - p(HGNC:CHRNB4, var("?")) positiveCorrelation path(MESH:"Cocaine-Related Disorders") - + - pmid:21482353 + pubmed:26445701 - p(HGNC:CHRNB4, var("?")) positiveCorrelation path(MESH:"Opioid-Related Disorders") + complex(p(HGNC:VCAM1), p(MESH:"Receptors, Very Late Antigen")) increases bp(MESH:"Transendothelial and Transepithelial Migration") + + - pmid:21482353 + pubmed:28901280 - p(HGNC:CHRNB4, var("?")) positiveCorrelation path(MESH:"Lung Neoplasms") + a(MESH:Lymphocytes) association r(HGNC:CHRFAM7A) - pmid:21482353 + pubmed:30988501 - p(HGNC:CHRNB4, var("?")) positiveCorrelation bp(GO:cognition) + a(DRUGBANK:Alemtuzumab) isA p(MESH:"Antibodies, Monoclonal") + + - pmid:21482353 + pubmed:30988501 - path(MESH:"Tobacco Use") decreases path(MESH:"Parkinson Disease") + a(DRUGBANK:Alemtuzumab) increases complex(a(DRUGBANK:Alemtuzumab), p(HGNC:CD52)) - pmid:18986241 + pubmed:30988501 - path(MESH:D019636) association path(MESH:D000544) + a(DRUGBANK:Alemtuzumab) increases deg(a(MESH:B-Lymphocytes)) - pmid:18986241 + pubmed:30988501 - path(MESH:D001526) association path(MESH:D000544) + a(DRUGBANK:Alemtuzumab) increases deg(a(MESH:T-Lymphocytes)) - pmid:18986241 + pubmed:30988501 - path(HBP:aMCI) association path(MESH:D008569) + a(DRUGBANK:Alemtuzumab) decreases path(MESH:Recurrence) - pmid:18986241 + pubmed:30988501 - path(HBP:aMCI) association path(MESH:D003704) + a(DRUGBANK:Alemtuzumab) decreases path(DOID:"multiple sclerosis") - pmid:18986241 + pubmed:30988501 - path(HBP:aMCI) association path(MESH:D000544) + a(DRUGBANK:Alemtuzumab) increases path(MESH:"Injection Site Reaction") - pmid:18986241 + pubmed:30988501 - path(MESH:D008569) association path(HBP:aMCI) + a(DRUGBANK:Alemtuzumab) increases path(MESH:"Stomatitis, Herpetic") - pmid:18986241 + pubmed:30988501 - path(HBP:mdMCI) association path(MESH:D060825) + a(DRUGBANK:Alemtuzumab) increases path(MESH:Mycoses) - pmid:18986241 + pubmed:30988501 - path(MESH:D060825) association path(HBP:mdMCI) + a(DRUGBANK:Alemtuzumab) increases path(MESH:"Thyroid Diseases") - pmid:18986241 + pubmed:30988501 - path(MESH:D060825) association path(MESH:D062706) + a(DRUGBANK:Alemtuzumab) increases path(DOID:thrombocytopenia) - pmid:18986241 + pubmed:30988501 - path(MESH:D060825) association bp(HBP:Neurodegeneration) + a(DRUGBANK:Alemtuzumab) increases path(DOID:glomerulonephritis) - pmid:18986241 + pubmed:30988501 - path(MESH:D060825) causesNoChange act(p(HGNC:CHAT)) + a(DRUGBANK:Alemtuzumab) increases path(MESH:"Autoimmune Diseases") - pmid:18986241 + pubmed:30988501 - path(MESH:D060825) increases act(p(HGNC:CHAT)) + a(DRUGBANK:Alemtuzumab) decreases path(MESH:"Multiple Sclerosis, Relapsing-Remitting") + + - pmid:18986241 + pubmed:27794524 - path(MESH:D060825) increases act(p(HGNC:CHAT)) + a(MESH:B-Lymphocytes) association path(MESH:"Tertiary Lymphoid Structures") - pmid:18986241 + pubmed:26445701 - path(MESH:D060825) decreases a(MESH:D013569) + act(a(MESH:B-Lymphocytes)) increases deg(a(GO:"myelin sheath")) - pmid:18986241 + pubmed:26445701 - path(MESH:D060825) increases act(p(HGNC:MMP9)) + a(MESH:B-Lymphocytes) association path(DOID:"multiple sclerosis") - pmid:18986241 + pubmed:26445701 - path(MESH:D060825) causesNoChange r(HGNC:CHAT) + a(MESH:B-Lymphocytes) increases path(MESH:Inflammation) + + - pmid:18986241 + pubmed:30988501 - path(MESH:D060825) association p(HGNC:CHRM1) + a(MESH:B-Lymphocytes) causesNoChange bp(GO:"learning or memory") - pmid:18986241 + pubmed:30988501 - path(MESH:D060825) decreases a(HBP:"3R tau") + act(a(MESH:B-Lymphocytes)) association bp(GO:"embryonic brain development") - - - pmid:18986241 - - path(MESH:D062706) association path(MESH:D060825) - + - pmid:18986241 + pubmed:30988501 - a(MESH:D059329) directlyIncreases bp(GO:"GO:0060384") + a(MESH:T-Lymphocytes) increases bp(MESH:"Immunologic Surveillance") - pmid:18986241 + pubmed:30988501 - a(MESH:D059329) association path(MESH:D008568) + a(MESH:T-Lymphocytes) increases bp(GO:"cytokine secretion") - pmid:18986241 + pubmed:30988501 - a(MESH:D059329) association path(MESH:D001288) + a(MESH:T-Lymphocytes) increases bp(GO:"learning or memory") - pmid:18986241 + pubmed:30988501 - a(MESH:D059329) association a(MESH:D016874) + a(CHEBI:corticosteroid) decreases path(MESH:"Injection Site Reaction") - pmid:18986241 + pubmed:27956442 - a(MESH:D059329) association path(MESH:D000544) + a(CHEBI:corticosteroid) decreases path(MESH:"Multiple Sclerosis, Relapsing-Remitting") - pmid:18986241 + pubmed:26445701 - a(MESH:D059329) association a(MESH:D009479) + a(CHEBI:corticosteroid) decreases path(DOID:"relapsing-remitting multiple sclerosis") - pmid:18986241 + pubmed:26445701 - a(MESH:D059329) association a(MESH:D059330) + a(CHEBI:corticosteroid) decreases path(MESH:Inflammation) - pmid:18986241 + pubmed:26445701 - a(MESH:D059329) association p(RGD:Gal) + a(CHEBI:corticosteroid) isA a(CHEBI:immunomodulator) - pmid:18986241 + pubmed:30988501 - a(MESH:D059329) association path(MESH:D008570) + a(MESH:"Histamine Antagonists") decreases path(MESH:"Injection Site Reaction") - pmid:18986241 + pubmed:30988501 - a(MESH:D059329) association path(MESH:D003704) + a(DRUGBANK:Acyclovir) decreases path(MESH:"Stomatitis, Herpetic") - pmid:18986241 + pubmed:30988501 - bp(GO:"GO:0060384") association p(HGNC:NGF) + a(DRUGBANK:Acyclovir) decreases path(MESH:Mycoses) - pmid:18986241 + pubmed:27794524 - path(MESH:D001288) association a(MESH:D059329) + path(MESH:"Autoimmune Diseases") association bp(GO:"microglial cell activation") - pmid:18986241 + pubmed:30988501 - a(MESH:D016874) association a(MESH:D059329) + a(DRUGBANK:Daclizumab) isA p(MESH:"Antibodies, Monoclonal") - pmid:18986241 + pubmed:30988501 - a(MESH:D016874) association path(MESH:D000544) + a(DRUGBANK:Daclizumab) decreases p(HGNC:IL2) - pmid:18986241 + pubmed:30988501 - a(MESH:D016874) association p(HGNC:BCHE) + a(DRUGBANK:Daclizumab) decreases path(MESH:Recurrence) - pmid:18986241 + pubmed:30988501 - a(MESH:D009479) association a(MESH:D059329) + a(DRUGBANK:Ocrelizumab) isA p(MESH:"Antibodies, Monoclonal") + + - pmid:18986241 + pubmed:30988501 - a(MESH:D059330) association a(MESH:D059329) + a(DRUGBANK:Ocrelizumab) increases complex(a(DRUGBANK:Ocrelizumab), p(HGNC:MS4A1)) - pmid:18986241 + pubmed:30988501 - p(RGD:Gal) association a(MESH:D059329) + a(DRUGBANK:Ocrelizumab) decreases path(MESH:Recurrence) + + - pmid:18986241 + pubmed:30988501 - path(MESH:D008570) association a(MESH:D059329) + a(DRUGBANK:Rituximab) isA p(MESH:"Antibodies, Monoclonal") - pmid:18986241 + pubmed:30988501 - a(MESH:D005625) positiveCorrelation path(MESH:D011597) + a(DRUGBANK:Rituximab) increases complex(a(DRUGBANK:Ocrelizumab), p(HGNC:MS4A1)) - pmid:18986241 + pubmed:30967783 - path(MESH:D011597) positiveCorrelation a(MESH:D005625) + bp(MESH:"Adaptive Immunity") decreases p(MESH:Proteins, pmod(CONSO:misfolded)) - pmid:18986241 + pubmed:30988501 - p(HGNC:BCHE, var("p.Ala539Thr")) decreases p(HGNC:BCHE) + bp(MESH:"Adaptive Immunity") increases bp(GO:cognition) - - - - - pmid:18986241 + pubmed:30988501 - complex(p(HGNC:NGF), p(HGNC:NTRK1)) increases bp(GO:"GO:0038180") + bp(MESH:"Adaptive Immunity") increases bp(GO:"learning or memory") - pmid:18986241 + pubmed:30988501 - complex(p(HGNC:NGF), p(HGNC:NTRK1)) increases bp(GO:"GO:0031175") + bp(MESH:"Adaptive Immunity") increases path(MESH:Pathology) - pmid:18986241 + pubmed:27794524 - p(HGNC:NTRK1) negativeCorrelation path(MESH:D003072) + bp(GO:"brain development") negativeCorrelation bp(GO:"inflammatory response") - pmid:18986241 + pubmed:30985105 - p(HGNC:NTRK1) biomarkerFor path(MESH:D000544) + bp(GO:"brain development") association p(HGNC:OGA) - pmid:18986241 + pubmed:30988501 - p(HGNC:NTRK1) decreases act(p(HGNC:BACE1)) + bp(GO:"brain development") increases bp(GO:"complement-mediated synapse pruning") - - - pmid:18986241 + pubmed:27794524 - bp(GO:"GO:0038180") increases bp(GO:"GO:1990089") + bp(GO:"central nervous system development") positiveCorrelation bp(GO:"inflammatory response") - - - - - pmid:18986241 + pubmed:27794524 - complex(p(HGNC:NGF), p(HGNC:NGFR)) increases complex(p(HGNC:NGF), p(HGNC:NTRK1)) + bp(GO:"central nervous system development") association a(CHEBI:laquinimod) - pmid:18986241 + pubmed:27794524 - bp(GO:"GO:1901214") association p(HGNC:NGFR) + path(MESH:"Disease Resistance") decreases path(MESH:Inflammation) - pmid:18986241 + pubmed:27794524 - path(MESH:D003072) negativeCorrelation p(HGNC:NTRK1) + path(MESH:"Multiple Sclerosis, Chronic Progressive") increases path(MESH:Inflammation) - pmid:18986241 + pubmed:27956442 - path(MESH:D003072) positiveCorrelation act(p(HGNC:MMP9)) + path(MESH:"Multiple Sclerosis, Chronic Progressive") increases path(MESH:Inflammation) - pmid:18986241 + pubmed:27794524 - bp(MESH:D000375) increases p(HGNC:NGFR) + path(MESH:"Multiple Sclerosis, Chronic Progressive") increases path(MESH:Atrophy) - pmid:18986241 + pubmed:27956442 - p(HGNC:SORT1) association path(MESH:D000544) + path(MESH:"Multiple Sclerosis, Chronic Progressive") directlyIncreases path(MESH:Atrophy) - pmid:18986241 + pubmed:27956442 - act(p(HGNC:MMP9)) positiveCorrelation path(MESH:D003072) + path(MESH:"Multiple Sclerosis, Chronic Progressive") directlyIncreases path(MESH:"Diffuse Axonal Injury") - pmid:27594586 + pubmed:27794524 - p(HGNC:MMP9) increases p(HGNC:HTT, frag("?")) + path(MESH:B-Lymphocytes) association path(MESH:Meningitis) - pmid:27594586 + pubmed:27794524 - act(p(HGNC:MMP9)) association path(MESH:"Neurodevelopmental Disorders") + path(MESH:Meningitis) association path(MESH:B-Lymphocytes) - pmid:27594586 + pubmed:27794524 - act(p(HGNC:MMP9)) increases bp(GO:"neuron death") + path(MESH:Meningitis) increases bp(GO:"neuron death") - pmid:27594586 + pubmed:27794524 - p(HGNC:MMP9) increases bp(GO:"neuron death") + path(MESH:Meningitis) increases path(MESH:"Multiple Sclerosis, Chronic Progressive") - pmid:27594586 + pubmed:27889190 - act(p(HGNC:MMP9)) positiveCorrelation p(FPLX:ERK, pmod(Ph)) + path(MESH:Meningitis) positiveCorrelation path(HP:"CNS demyelination") - pmid:27594586 + pubmed:27794524 - sec(p(HGNC:MMP9)) positiveCorrelation p(FPLX:ERK, pmod(Ph)) + p(MESH:B-Lymphocytes) increases path(MESH:"Antibody Formation") - pmid:26195256 + pubmed:27794524 - p(HGNC:MMP9) increases deg(a(CHEBI:"amyloid-beta", loc(GO:"extracellular region"))) + p(MESH:B-Lymphocytes) increases tloc(a(MESH:Cytokines), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:29626319 + pubmed:27794524 - act(p(HGNC:MMP9)) increases deg(a(CHEBI:"amyloid-beta")) + p(MESH:B-Lymphocytes) increases path(MESH:"Antigen Presentation") - pmid:29626319 + pubmed:27794524 - p(HGNC:MMP9) increases deg(a(CHEBI:"amyloid-beta")) + p(MESH:B-Lymphocytes) increases path(MESH:"Tertiary Lymphoid Structures") - pmid:18986241 + pubmed:27794524 - g(HGNC:NTRK1) association path(MESH:D003071) + p(MESH:B-Lymphocytes) increases path(MESH:"Wounds and Injuries") - pmid:18986241 + pubmed:27794524 - g(HGNC:NTRK2) association path(MESH:D003071) + path(MESH:"Tertiary Lymphoid Structures") association a(MESH:B-Lymphocytes) - pmid:18986241 + pubmed:27794524 - g(HGNC:NTRK3) association path(MESH:D003071) + path(MESH:"Tertiary Lymphoid Structures") association a(MESH:"Plasma Cells") - pmid:18986241 + pubmed:27794524 - bp(GO:"GO:0000165") association bp(GO:"GO:0006915") + path(MESH:"Tertiary Lymphoid Structures") association a(MESH:"T-Lymphocytes, Helper-Inducer") - pmid:18986241 + pubmed:27794524 - bp(GO:"GO:0000165") association bp(GO:"GO:0030182") + path(MESH:"Tertiary Lymphoid Structures") association a(MESH:"Dendritic Cells, Follicular") - pmid:18986241 + pubmed:27794524 - bp(GO:"GO:0000165") increases act(p(FPLX:RAS)) + path(MESH:"Tertiary Lymphoid Structures") positiveCorrelation path(MESH:"Neurodegenerative Diseases") - pmid:18986241 + pubmed:27794524 - bp(GO:"GO:0000165") increases act(p(FPLX:RAF)) + path(MESH:"Tertiary Lymphoid Structures") positiveCorrelation path(MESH:Atrophy) - pmid:18986241 + pubmed:27794524 - bp(GO:"GO:0000165") increases act(p(FPLX:MEK)) + path(MESH:"Tertiary Lymphoid Structures") positiveCorrelation path(MESH:"Demyelinating Diseases") - pmid:18986241 + pubmed:27794524 - bp(GO:"GO:0000165") increases act(p(FPLX:P90RSK)) + path(MESH:"Tertiary Lymphoid Structures") decreases path(MESH:"Age of Onset") - pmid:18986241 + pubmed:27794524 - bp(GO:"GO:0000165") increases act(p(HGNC:MAPKAPK2)) + path(MESH:"Tertiary Lymphoid Structures") directlyIncreases bp(GO:"neuron death") - pmid:18986241 + pubmed:27794524 - bp(GO:"GO:0006915") association bp(GO:"GO:0000165") + path(MESH:"Tertiary Lymphoid Structures") causesNoChange path(MESH:Meningitis) - pmid:18986241 + pubmed:27794524 - bp(GO:"GO:0030182") association bp(GO:"GO:0000165") + path(MESH:"Tertiary Lymphoid Structures") causesNoChange path(MESH:Pathology) - pmid:18986241 + pubmed:27794524 - act(p(HGNC:MAPKAPK2)) increases p(HGNC:ELK1, pmod(Ph)) + p(HGNC:LTA) isA a(MESH:Cytokines) - pmid:18986241 + pubmed:27794524 - act(p(HGNC:MAPKAPK2)) increases p(HGNC:CREB1, pmod(Ph)) + p(HGNC:LTA) positiveCorrelation path(MESH:"Complement Activation") - - - pmid:18986241 + pubmed:27794524 - bp(GO:"GO:0014065") regulates bp(MESH:D002470) + p(HGNC:LTA) positiveCorrelation act(p(MESH:T-Lymphocytes)) - pmid:18986241 + pubmed:27794524 - bp(GO:"GO:0014065") association p(FPLX:RAS) + p(HGNC:IL10) regulates a(MESH:Cytokines) - pmid:18986241 + pubmed:27794524 - bp(GO:"GO:0014065") association p(HGNC:IRS1) + p(HGNC:IL10) negativeCorrelation path(MESH:"Complement Activation") - pmid:18986241 + pubmed:27794524 - bp(GO:"GO:0014065") association p(HGNC:GAB1) + p(HGNC:IL10) negativeCorrelation act(p(MESH:T-Lymphocytes)) - pmid:18986241 + pubmed:30967783 - bp(GO:"GO:0043491") regulates bp(MESH:D002470) + p(HGNC:IL10) increases act(a(NCIT:C123783)) - pmid:18986241 + pubmed:30967783 - bp(GO:"GO:0043491") association p(FPLX:RAS) + p(HGNC:IL10) decreases bp(GO:"inflammatory response") - pmid:18986241 + pubmed:21718217 - bp(GO:"GO:0043491") association p(HGNC:IRS1) + p(HGNC:IL10) decreases a(MESH:Macrophages) - pmid:18986241 + pubmed:27794524 - bp(GO:"GO:0043491") association p(HGNC:GAB1) + complex(p(HGNC:EBI3), p(HGNC:IL12A)) regulates a(MESH:Cytokines) - pmid:18986241 + pubmed:27794524 - p(HGNC:IRS1) association bp(GO:"GO:0014065") + complex(p(HGNC:EBI3), p(HGNC:IL12A)) negativeCorrelation path(MESH:"Complement Activation") - pmid:18986241 + pubmed:27794524 - p(HGNC:IRS1) association bp(GO:"GO:0043491") + complex(p(HGNC:EBI3), p(HGNC:IL12A)) negativeCorrelation act(p(MESH:T-Lymphocytes)) - - - pmid:18986241 - - p(HGNC:GAB1) association bp(GO:"GO:0014065") - + - pmid:18986241 + pubmed:27794524 - p(HGNC:GAB1) association bp(GO:"GO:0043491") + path(MESH:"Complement Activation") positiveCorrelation p(HGNC:TNF) - pmid:18986241 + pubmed:27794524 - act(p(HGNC:PLCG1)) association bp(MESH:D018384) + path(MESH:"Complement Activation") positiveCorrelation p(HGNC:LTA) - - - pmid:18467332 + pubmed:27794524 - p(HGNC:PLCG1) isA complex(p(HGNC:MAPT), p(HGNC:PLCG1)) + path(MESH:"Complement Activation") positiveCorrelation p(HGNC:IL6) - pmid:18986241 + pubmed:27794524 - bp(MESH:D018384) association act(p(HGNC:PLCG1)) + path(MESH:"Complement Activation") negativeCorrelation p(HGNC:IL10) - pmid:18986241 + pubmed:27794524 - bp(MESH:D018384) association path(MESH:D000375) + path(MESH:"Complement Activation") negativeCorrelation complex(p(HGNC:EBI3), p(HGNC:IL12A)) - pmid:18986241 + pubmed:27794524 - bp(MESH:D018384) association path(MESH:D009410) + act(p(MESH:T-Lymphocytes)) positiveCorrelation p(HGNC:TNF) - pmid:18986241 + pubmed:27794524 - path(MESH:D000375) association bp(MESH:D018384) + act(p(MESH:T-Lymphocytes)) positiveCorrelation p(HGNC:LTA) - pmid:18986241 + pubmed:27794524 - path(MESH:D009410) association bp(MESH:D018384) + act(p(MESH:T-Lymphocytes)) positiveCorrelation p(HGNC:IL6) - pmid:18986241 + pubmed:27794524 - bp(GO:"GO:0006665") association act(p(HGNC:NGFR)) + act(p(MESH:T-Lymphocytes)) negativeCorrelation p(HGNC:IL10) - pmid:18986241 + pubmed:27794524 - p(HGNC:NTRK1, pmod(Ph)) increases bp(GO:"GO:0043491") + act(p(MESH:T-Lymphocytes)) negativeCorrelation complex(p(HGNC:EBI3), p(HGNC:IL12A)) - pmid:18986241 + pubmed:27794524 - p(HGNC:NTRK1, pmod(Ph)) increases bp(GO:"GO:0000165") + a(MESH:"Plasma Cells") association path(MESH:"Tertiary Lymphoid Structures") - - - pmid:18986241 + pubmed:27794524 - path(MESH:D024801) association p(HGNC:CHRM1) + a(MESH:"T-Lymphocytes, Helper-Inducer") association path(MESH:"Tertiary Lymphoid Structures") - pmid:18986241 + pubmed:27794524 - path(MESH:D000686) association p(HGNC:CHRM1) + a(MESH:"Dendritic Cells, Follicular") association path(MESH:"Tertiary Lymphoid Structures") - pmid:26751493 + pubmed:27794524 - r(HGNC:SYP) negativeCorrelation a(GO:"neurofibrillary tangle") + a(MESH:"Dendritic Cells, Follicular") increases tloc(p(HGNC:CXCL13), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:18986241 + pubmed:27794524 - bp(HBP:hyperphosphorylation) association path(MESH:D016874) + p(HGNC:CXCL13) positiveCorrelation a(MESH:"B-Cell Maturation Antigen") - - - pmid:17493042 + pubmed:27794524 - p(HBP:"Tau isoform B (381 aa)") partOf a(MESH:Brain) + p(HGNC:CXCL13) positiveCorrelation bp(GO:"regulation of B cell chemotaxis") - pmid:23407988 + pubmed:27794524 - p(HBP:"Tau isoform B (381 aa)") isA p(HBP:"3R tau") + p(HGNC:CXCL13) positiveCorrelation bp(GO:"B cell selection") - - - - - - - pmid:17493042 + pubmed:27794524 - p(HBP:"Tau isoform C (410 aa)") partOf a(MESH:Brain) + a(MESH:"B-Cell Maturation Antigen") positiveCorrelation p(HGNC:CXCL13) - pmid:23407988 + pubmed:27794524 - p(HBP:"Tau isoform C (410 aa)") isA p(HBP:"3R tau") + bp(GO:"regulation of B cell chemotaxis") positiveCorrelation p(HGNC:CXCL13) - - - - - - - - - - - - - - - - - - - - - pmid:17493042 + pubmed:27794524 - p(HBP:"Tau isoform D (383 aa)") partOf a(MESH:Brain) + bp(GO:"B cell selection") positiveCorrelation p(HGNC:CXCL13) - pmid:23407988 + pubmed:27794524 - p(HBP:"Tau isoform D (383 aa)") isA p(HBP:"4R tau") + path(MESH:"Immunity, Humoral") causesNoChange path(MESH:"Tertiary Lymphoid Structures") - - - - - - - - - - - pmid:17493042 + pubmed:27794524 - p(HBP:"Tau isoform E (412 aa)") partOf a(MESH:Brain) + path(MESH:Atrophy) positiveCorrelation bp(GO:"inflammatory response") - pmid:23407988 + pubmed:27794524 - p(HBP:"Tau isoform E (412 aa)") isA p(HBP:"4R tau") + path(MESH:Atrophy) positiveCorrelation path(MESH:"Tertiary Lymphoid Structures") - - - - - - - - - - - - - - - - - - - - - - - - - - - pmid:29191965 + pubmed:27794524 - p(HBP:"Tau isoform F (441 aa)") decreases bp(GO:"anterograde axonal transport of mitochondrion") + path(MESH:Atrophy) increases path(MESH:"Developmental Disabilities") - pmid:29191965 + pubmed:27956442 - p(HBP:"Tau isoform F (441 aa)") decreases bp(GO:"retrograde axonal transport of mitochondrion") + path(MESH:Atrophy) increases path(MESH:"Neurodegenerative Diseases") - - - pmid:25374103 + pubmed:27956442 - p(HBP:"Tau isoform F (441 aa)") causesNoChange bp(GO:"cell death") + path(MESH:Atrophy) directlyIncreases bp(GO:"microglial cell activation") - pmid:25374103 + pubmed:27889190 - p(HBP:"Tau isoform F (441 aa)") increases act(p(HGNC:CASP3)) + path(MESH:Atrophy) decreases bp(GO:cognition) - pmid:25374103 + pubmed:27889190 - p(HBP:"Tau isoform F (441 aa)") decreases bp(GO:"mitochondrion transport along microtubule") + path(MESH:Atrophy) decreases bp(GO:cognition) - pmid:25374103 + pubmed:27889190 - p(HBP:"Tau isoform F (441 aa)") decreases bp(GO:"mitochondrion transport along microtubule") + path(MESH:Atrophy) increases path(MESH:"Motor Disorders") - pmid:17493042 + pubmed:27889190 - p(HBP:"Tau isoform F (441 aa)") partOf a(MESH:Brain) + path(MESH:Atrophy) increases path(MESH:"Motor Disorders") - - - - - - - - - - - pmid:23407988 + pubmed:27889190 - p(HBP:"Tau isoform F (441 aa)") isA p(HBP:"4R tau") + path(MESH:Atrophy) increases path(NCIT:C21007) - - - - - - - - - pmid:30145931 + pubmed:25687773 - r(HGNC:MAPT, loc(MESH:Dendrites)) increases p(HGNC:MAPT, loc(MESH:Dendrites)) + path(MESH:Atrophy) association g(DBSNP:rs393152) - pmid:27574109 + pubmed:25687773 - a(HBP:"3R tau") positiveCorrelation path(MESH:"Protein Aggregation, Pathological") + path(MESH:Atrophy) positiveCorrelation g(DBSNP:rs393152) - pmid:27574109 + pubmed:25687773 - a(HBP:"3R tau") positiveCorrelation path(MESH:"Protein Aggregation, Pathological") + path(MESH:Atrophy) association path(MESH:"Alzheimer Disease") - pmid:27574109 + pubmed:26195256 - a(HBP:"3R tau") positiveCorrelation bp(GO:"positive regulation of protein oligomerization") + path(MESH:Atrophy) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27574109 + pubmed:30012004 - a(HBP:"3R tau") positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:Atrophy) positiveCorrelation path(MESH:"Huntington Disease") - pmid:27574109 + pubmed:27794524 - a(HBP:"3R tau") positiveCorrelation path(MESH:"Pick Disease of the Brain") + path(MESH:Pathology) increases path(MESH:"Multiple Sclerosis, Chronic Progressive") - pmid:18986241 + pubmed:27794524 - act(p(HGNC:GAL)) association path(MESH:D003071) + p(NCBIGENE:7707, loc(MESH:"Plasma Cells")) association path(MESH:"Epstein-Barr Virus Infections") - pmid:18986241 + pubmed:27794524 - act(p(HGNC:GAL)) association bp(MESH:D009473) + bp(GO:"CD8-positive, alpha-beta T cell differentiation involved in immune response") directlyIncreases a(MESH:Cytotoxins) - pmid:18986241 + pubmed:30837838 - act(p(HGNC:GAL)) increases bp(GO:"GO:0060384") + a(MESH:Cytotoxins) association p(HGNC:TARDBP, frag("274_414")) - pmid:18986241 + pubmed:26445701 - act(p(HGNC:GAL)) regulates act(a(MESH:D059329)) + a(MESH:"CD8-Positive T-Lymphocytes") increases path(DOID:"axonal neuropathy") - pmid:18986241 + pubmed:26445701 - act(p(HGNC:GAL)) decreases a(CHEBI:"amyloid-beta") + a(MESH:"CD8-Positive T-Lymphocytes") increases path(HP:"CNS demyelination") - pmid:18986241 + pubmed:26445701 - act(p(HGNC:GAL)) increases r(HGNC:CHAT) + a(MESH:"CD8-Positive T-Lymphocytes") increases path(MESH:"Diffuse Axonal Injury") - pmid:18986241 + pubmed:26445701 - act(p(HGNC:GAL)) causesNoChange a(HBP:"Tau MN423") + a(MESH:"CD8-Positive T-Lymphocytes") increases bp(GO:"positive regulation of oligodendrocyte apoptotic process") + + - pmid:18986241 + pubmed:27794524 - act(p(HGNC:GAL)) increases r(HGNC:PPP1CA) + a(MESH:"T-Lymphocytes, Cytotoxic") increases tloc(p(HGNC:TNF), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:18986241 + pubmed:27794524 - act(p(HGNC:GAL)) increases r(HGNC:PPP1CC) + a(MESH:"T-Lymphocytes, Cytotoxic") increases tloc(p(HGNC:IFNG), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:18986241 + pubmed:27794524 - bp(MESH:D009473) association act(p(HGNC:GAL)) + a(MESH:"T-Lymphocytes, Cytotoxic") increases tloc(p(HGNC:PRF1), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:18986241 + pubmed:27794524 - a(HBP:"Tau C3") biomarkerFor path(MESH:D059329) + a(MESH:"T-Lymphocytes, Cytotoxic") increases tloc(p(HGNC:GZMA), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:18986241 + pubmed:27794524 - p(RGD:Ngf) increases r(RGD:Gal) + a(MESH:"T-Lymphocytes, Cytotoxic") increases tloc(p(HGNC:GZMB), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + - pmid:18986241 + pubmed:30988501 - p(RGD:Ngf) decreases path(MESH:D060825) + a(MESH:"T-Lymphocytes, Cytotoxic") increases path(HP:"CNS demyelination") - pmid:18986241 + pubmed:30988501 - bp(GO:"GO:0050435") association a(MESH:D002800) + a(MESH:"T-Lymphocytes, Cytotoxic") increases deg(a(MESH:Neurons)) - pmid:18986241 + pubmed:27794524 - path(MESH:D007319) association a(MESH:D002800) + p(HGNC:PRF1) increases bp(GO:"sodium ion import across plasma membrane") - pmid:18986241 + pubmed:27794524 - path(MESH:D003967) association a(MESH:D002800) + p(HGNC:PRF1) increases bp(GO:"calcium ion import") - pmid:18986241 + pubmed:27794524 - path(MESH:D009325) association a(MESH:D002800) + p(HGNC:GZMA) increases bp(GO:"sodium ion import across plasma membrane") - pmid:18986241 + pubmed:27794524 - path(MESH:D005221) association a(MESH:D002800) + p(HGNC:GZMA) increases bp(GO:"calcium ion import") - pmid:18986241 + pubmed:27794524 - path(MESH:D000855) association a(MESH:D002800) + p(HGNC:GZMB) increases bp(GO:"sodium ion import across plasma membrane") - pmid:18986241 + pubmed:27794524 - bp(GO:"GO:0007269") association p(HGNC:NGF) + p(HGNC:GZMB) increases bp(GO:"calcium ion import") - pmid:18986241 + pubmed:27794524 - bp(GO:"GO:0048485") association p(HGNC:NGF) + bp(GO:"glutamate homeostasis") negativeCorrelation p(HGNC:IFNG) - pmid:18986241 + pubmed:27794524 - path(MESH:D002100) association p(HGNC:NGF) + complex(p(HGNC:IFNG), p(HGNCGENEFAMILY:"Glutamate ionotropic receptor AMPA type subunits")) regulates bp(GO:"calcium ion import") - pmid:18986241 + pubmed:27794524 - path(MESH:D006930) association p(HGNC:NGF) + bp(GO:"sodium ion import across plasma membrane") increases path(MESH:"Energy Metabolism") - pmid:18986241 + pubmed:26979166 - g(HGNC:NGF) directlyIncreases p(HGNC:NGF) + bp(GO:"sodium ion import across plasma membrane") increases tloc(a(CHEBI:neurotransmitter), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:11230871 + pubmed:27794524 - a(MESH:"Neurotransmitter Agents") association p(FPLX:CHRN) + p(HGNC:FASLG) increases composite(a(MESH:"T-Lymphocytes, Cytotoxic"), p(HGNC:FAS)) - pmid:11230871 + pubmed:27794524 - path(MESH:"Tourette Syndrome") association p(FPLX:CHRN) + composite(a(MESH:"T-Lymphocytes, Cytotoxic"), p(HGNC:FAS)) increases act(a(MESH:Caspases)) - - - - - - - - - - - - - - - pmid:11230871 + pubmed:19293145 - r(HBP:"alpha-4-containing nAChR") negativeCorrelation bp(GO:aging) + act(p(HGNC:FAS)) increases bp(GO:"programmed cell death") - pmid:11230871 + pubmed:23702978 - r(HBP:"alpha-7-containing nAChR") negativeCorrelation bp(GO:aging) + act(p(HGNC:FAS)) increases act(p(HGNC:IL1B)) - pmid:11230871 + pubmed:23702978 - a(PUBCHEM:5662) association bp(GO:"synaptic transmission, cholinergic") + act(p(HGNC:FAS)) increases act(p(HGNC:CASP8)) - pmid:11230871 + pubmed:27794524 - a(PUBCHEM:132228) increases p(FPLX:CHRN) + act(a(MESH:Caspases)) increases path(MESH:"Nerve Degeneration") - pmid:11230871 + pubmed:21214928 - a(CHEBI:Ondansetron) decreases p(FPLX:CHRN) + a(MESH:Caspases) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:amyloid-beta))) - pmid:11230871 + pubmed:21214928 - a(PUBCHEM:119380) increases path(MESH:"Verbal Learning") + a(MESH:Caspases) increases path(MESH:"Alzheimer Disease") - pmid:11230871 + pubmed:21214928 - a(PUBCHEM:119380) increases bp(GO:memory) + a(MESH:Caspases) increases rxn(reactants(p(CONSO:CONSO00071)), products(p(CONSO:CONSO00069), p(CONSO:CONSO00070))) - pmid:28132910 + pubmed:21214928 - a(HBP:"B-973") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + a(MESH:Caspases) increases rxn(reactants(p(HGNC:APP)), products(p(CONSO:CONSO00069))) - pmid:28132910 + pubmed:21214928 - a(HBP:"B-973") negativeCorrelation act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + a(MESH:Caspases) increases rxn(reactants(p(HGNC:APP)), products(p(CONSO:CONSO00070))) - pmid:28132910 + pubmed:22122372 - a(HBP:"B-973") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + a(MESH:Caspases) increases rxn(reactants(p(HGNC:APP)), products(p(CONSO:CONSO00069), p(CONSO:CONSO00070))) - pmid:28132910 + pubmed:29215007 - a(HBP:"B-973") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + a(MESH:Caspases) increases p(HGNC:MAPT, var("?")) - pmid:28132910 + pubmed:27794524 - a(HBP:"B-973") increases act(a(CHEBI:acetylcholine)) + path(MESH:"Nerve Degeneration") association bp(GO:"microglial cell activation") - pmid:28132910 + pubmed:27794524 - a(HBP:"B-973") increases act(p(HGNC:CHRNA7)) + path(MESH:"Nerve Degeneration") association a(PUBCHEM:65065) - pmid:28132910 + pubmed:18986241 - a(HBP:"B-973") increases complex(a(GO:membrane), a(PUBCHEM:16068384)) + path(MESH:"Nerve Degeneration") association bp(MESH:"Oxidative Stress") - pmid:28132910 + pubmed:30837838 - a(HBP:"B-973") increases complex(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"), a(PUBCHEM:16068384)) + path(MESH:"Nerve Degeneration") association path(MESH:Transportation) - pmid:28132910 + pubmed:30837838 - a(HBP:"B-973") increases complex(a(PUBCHEM:16068384), p(MGI:Chrna7)) + path(MESH:"Nerve Degeneration") association path(MESH:"Mitochondrial Size") - - - - - - - - - - - - - pmid:28132910 + pubmed:30837838 - a(PUBCHEM:5288811) decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + path(MESH:"Nerve Degeneration") association a(CHEBI:"calcium(2+)") - pmid:28391535 + pubmed:30837838 - a(PUBCHEM:5288811) decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + path(MESH:"Nerve Degeneration") association path(MESH:"Cell Respiration") - pmid:28391535 + pubmed:30837838 - a(PUBCHEM:5288811) decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + path(MESH:"Nerve Degeneration") association bp(GO:"ATP biosynthetic process") - pmid:28391535 + pubmed:27794524 - a(PUBCHEM:5288811) causesNoChange act(a(CHEBI:nicotine)) + a(MESH:Oligodendroglia) directlyDecreases a(CHEBI:"iron(3+)", loc(GO:"extracellular space")) - pmid:28391535 + pubmed:27794524 - a(PUBCHEM:5288811) causesNoChange act(a(CHEBI:nicotine)) + a(MESH:Oligodendroglia) directlyIncreases tloc(p(HGNC:GDNF), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - + + + pubmed:27794524 + + a(MESH:Oligodendroglia) directlyIncreases tloc(p(HGNC:IGF1), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + - pmid:17640819 + pubmed:27794524 - composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu")), p(MGI:Psen1, var("p.Met146Leu"))) increases a(CHEBI:"amyloid-beta") + a(MESH:Oligodendroglia) directlyIncreases tloc(p(HGNC:BDNF), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - - - pmid:25881725 + pubmed:27889190 - a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") decreases act(p(MGI:App, frag("25_35"))) + a(MESH:Oligodendroglia) increases p(HGNC:LINGO1) - pmid:25881725 + pubmed:27889190 - a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") decreases act(p(MGI:App, frag("25_35"))) + a(MESH:Oligodendroglia) increases bp(MESH:Remyelination) - pmid:25881725 + pubmed:30967783 - a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases bp(GO:learning) + act(a(MESH:Oligodendroglia)) positiveCorrelation a(MESH:Astrocytes) - pmid:25881725 + pubmed:30967783 - a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases bp(GO:learning) + act(a(MESH:Oligodendroglia)) negativeCorrelation bp(GO:"neuroinflammatory response") - pmid:25881725 + pubmed:21543606 - a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases path(MESH:"Spatial Memory") + a(MESH:Oligodendroglia) decreases bp(GO:myelination) - pmid:25881725 + pubmed:27794524 - a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases path(MESH:"Spatial Memory") + act(a(MESH:Phagocytes)) directlyDecreases a(MESH:Oligodendroglia) - pmid:25881725 + pubmed:30967783 - a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") causesNoChange r(MGI:Chrna7) + a(MESH:Phagocytes) increases bp(GO:"neuroinflammatory response") - pmid:25881725 + pubmed:30967783 - a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases p(MGI:Chrna7) + a(MESH:Phagocytes) increases path(DOID:"multiple sclerosis") - pmid:25881725 + pubmed:30967783 - a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases p(MGI:Chrna7) + a(MESH:Phagocytes) increases bp(MESH:Neuroprotection) - pmid:19721446 + pubmed:30967783 - a(MESH:"Peripheral Nervous System") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + a(MESH:Phagocytes) decreases path(MESH:Inflammation) - pmid:19721446 + pubmed:26979166 - a(MESH:"Central Nervous System") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + act(a(MESH:Phagocytes)) increases a(MESH:"Reactive Oxygen Species") - pmid:19721446 + pubmed:26979166 - bp(GO:"regulation of cation channel activity") association a(CHEBI:acetylcholine) + act(a(MESH:Phagocytes)) increases a(MESH:"Reactive Nitrogen Species") - pmid:19721446 + pubmed:27794524 - p(HGNC:CHRNA7, frag("231_255")) association act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) + bp(GO:"regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II") positiveCorrelation bp(GO:"microglial cell activation") - pmid:19721446 + pubmed:27794524 - p(HGNC:CHRNA7, frag("231_255")) association act(a(PUBCHEM:11964458)) + bp(GO:"regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II") directlyDecreases a(MESH:Oligodendroglia) - pmid:19721446 + pubmed:27794524 - act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) association p(HGNC:CHRNA7, frag("231_255")) + path(MESH:"Mitochondrial Diseases") decreases path(MESH:"Energy Metabolism") - pmid:19721446 + pubmed:27794524 - act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) association p(HGNC:CHRNA7, frag("262_280")) + path(MESH:"Mitochondrial Diseases") decreases act(p(MESH:Mitochondria)) - pmid:19721446 + pubmed:27794524 - act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) association p(HGNC:CHRNA7, frag("470_490")) + path(MESH:"Mitochondrial Diseases") decreases act(p(MESH:"Electron Transport Chain Complex Proteins")) - pmid:19721446 + pubmed:27956442 - p(HGNC:CHRNA7, frag("262_280")) association act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) + path(MESH:"Mitochondrial Diseases") directlyIncreases path(MESH:Inflammation) - pmid:19721446 + pubmed:27794524 - p(HGNC:CHRNA7, frag("262_280")) association act(a(PUBCHEM:11964458)) + a(CHEBI:"reactive nitrogen species") directlyIncreases path(MESH:"Mitochondrial Diseases") - pmid:19721446 + pubmed:27794524 - p(HGNC:CHRNA7, frag("470_490")) association act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) + a(CHEBI:"reactive nitrogen species") isA a(MESH:Neurotoxins) - pmid:19721446 + pubmed:16566606 - p(HGNC:CHRNA7, frag("470_490")) association act(a(PUBCHEM:11964458)) + a(CHEBI:"reactive nitrogen species") decreases act(a(MESH:Neurons)) - pmid:19721446 + pubmed:16566606 - act(a(PUBCHEM:11964458)) association p(HGNC:CHRNA7, frag("231_255")) + a(CHEBI:"reactive nitrogen species") increases bp(GO:"neuron death") - pmid:19721446 + pubmed:27794524 - act(a(PUBCHEM:11964458)) association p(HGNC:CHRNA7, frag("262_280")) + a(CHEBI:laquinimod) decreases path(MESH:"Multiple Sclerosis") - pmid:19721446 + pubmed:27794524 - act(a(PUBCHEM:11964458)) association p(HGNC:CHRNA7, frag("470_490")) + a(CHEBI:laquinimod) association bp(GO:"central nervous system development") - pmid:19721446 + pubmed:27794524 - p(HGNC:CHRNA4, frag("331_600")) association p(HGNC:YWHAH) + a(CHEBI:laquinimod) decreases bp(GO:"astrocyte activation") - pmid:19721446 + pubmed:27794524 - p(HGNC:CHRNA4, frag("331_600")) association p(HGNC:VSNL1) + a(CHEBI:laquinimod) directlyDecreases bp(GO:"microglial cell activation") - pmid:19721446 + pubmed:27794524 - p(HGNC:YWHAH) association p(HGNC:CHRNA4, frag("331_600")) + a(CHEBI:laquinimod) decreases a(MESH:"Anti-Inflammatory Agents") - pmid:19721446 + pubmed:27794524 - p(HGNCGENEFAMILY:Tubulins) association p(HGNC:CHRNB2) + a(CHEBI:laquinimod) causesNoChange tloc(a(MESH:"Growth Differentiation Factors"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:19721446 + pubmed:27794524 - p(HGNCGENEFAMILY:"Clathrin subunits") association p(HGNC:CHRNB2) + a(CHEBI:laquinimod) decreases path(MESH:"Population Density") - pmid:19721446 + pubmed:27794524 - a(MESH:"AR-R 17779") increases bp(GO:learning) + a(CHEBI:laquinimod) decreases path(MESH:"Diffuse Axonal Injury") - pmid:19721446 + pubmed:27794524 - a(MESH:"AR-R 17779") increases bp(GO:memory) + a(CHEBI:laquinimod) decreases path(MESH:"Demyelinating Diseases") - pmid:19721446 + pubmed:27794524 - a(MESH:"AR-R 17779") decreases act(a(CHEBI:scopolamine)) + bp(GO:"astrocyte activation") directlyDecreases path(MESH:Disease) - pmid:19721446 + pubmed:27794524 - a(DRUGBANK:Facinicline) increases bp(GO:cognition) + bp(GO:"astrocyte activation") increases p(HGNC:B4GALT6) - pmid:19721446 + pubmed:27794524 - a(DRUGBANK:Facinicline) increases bp(GO:memory) + bp(GO:"astrocyte activation") directlyIncreases g(HGNC:CSF2) - pmid:19721446 + pubmed:27794524 - a(DRUGBANK:Facinicline) increases path(MESH:"Memory, Episodic") + bp(GO:"astrocyte activation") directlyIncreases g(HGNC:CCL2) - pmid:19721446 + pubmed:29196815 - a(MESH:"alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid") increases path(HBP:neurotoxicity) + bp(GO:"astrocyte activation") positiveCorrelation a(CONSO:CONSO00074) - pmid:19721446 + pubmed:27671637 - a(MESH:"Entorhinal Cortex") association bp(GO:memory) + bp(GO:"astrocyte activation") negativeCorrelation p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) - pmid:19721446 + pubmed:27314526 - path(MESH:"Attention Deficit Disorder with Hyperactivity") association a(MESH:"3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole") + bp(GO:"astrocyte activation") increases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:19721446 + pubmed:27314526 - path(MESH:"Attention Deficit Disorder with Hyperactivity") association a(MESH:pozanicline) + bp(GO:"astrocyte activation") increases tloc(p(HGNC:IL6), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:19721446 + pubmed:27314526 - a(MESH:pozanicline) association path(MESH:"Attention Deficit Disorder with Hyperactivity") + bp(GO:"astrocyte activation") increases tloc(p(HGNC:IL18), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:19721446 + pubmed:27314526 - bp(MESH:"Sensory Gating") association path(MESH:Schizophrenia) + bp(GO:"astrocyte activation") increases tloc(p(HGNC:NOS2), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:19721446 + pubmed:27956442 - bp(MESH:"Sensory Gating") association p(HGNC:CHRNA7) + path(MESH:"Diffuse Axonal Injury") increases path(MESH:"Neurodegenerative Diseases") - pmid:19721446 + pubmed:28445721 - a(CHEBI:tropisetron) increases act(p(HGNC:CHRNA7)) + path(MESH:Disease) association a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") - pmid:19721446 + pubmed:27794524 - a(CHEBI:tropisetron) decreases bp(MESH:"Sensory Gating") + p(HGNC:B4GALT5) directlyIncreases path(MESH:Disease) - pmid:19721446 + pubmed:27794524 - a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(CHEBI:nicotine)) + p(HGNC:B4GALT5) increases a(PUBCHEM:20057304) - pmid:28391535 + pubmed:27794524 - a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(CHEBI:nicotine)) + p(HGNC:B4GALT6) directlyIncreases path(MESH:Disease) - pmid:28391535 + pubmed:27794524 - a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(CHEBI:nicotine)) + p(HGNC:B4GALT6) increases a(PUBCHEM:20057304) - pmid:19721446 + pubmed:27794524 - a(MESH:"Dihydro-beta-Erythroidine") decreases act(p(HBP:"alpha-4 beta-2 nAChR")) + p(HGNC:B4GALT6) increases path(MESH:"Encephalomyelitis, Autoimmune, Experimental") - pmid:28901280 + pubmed:27794524 - a(MESH:"Dihydro-beta-Erythroidine") decreases p(MESH:"Receptors, Nicotinic") + p(HGNC:B4GALT6) increases path(MESH:"Neurodegenerative Diseases") - pmid:28901280 + pubmed:27794524 - a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(MESH:Nicotine)) + a(PUBCHEM:20057304) directlyIncreases bp(GO:"astrocyte activation") - pmid:28391535 + pubmed:27794524 - a(MESH:"Dihydro-beta-Erythroidine") increases complex(a(MESH:"Dihydro-beta-Erythroidine"), a(MESH:"nicotinic receptor alpha4beta2")) + path(MESH:"Encephalomyelitis, Autoimmune, Experimental") directlyIncreases a(PUBCHEM:20057304) - pmid:28391535 + pubmed:27794524 - a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(MESH:"Receptors, Nicotinic")) + g(HGNC:CSF2) increases bp(GO:"microglial cell activation") - pmid:28391535 + pubmed:27794524 - a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(MESH:"Receptors, Nicotinic")) + g(HGNC:CCL2) increases bp(GO:"microglial cell activation") - pmid:28391535 + pubmed:27794524 - a(MESH:"Dihydro-beta-Erythroidine") increases complex(a(MESH:"Dihydro-beta-Erythroidine"), p(HGNC:CHRNB2)) + a(MESH:Astrocytes) directlyIncreases a(CHEBI:"reactive oxygen species") - pmid:28391535 + pubmed:27794524 - a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(MESH:"nicotinic receptor alpha3beta2")) + a(MESH:Astrocytes) directlyIncreases a(CHEBI:"reactive nitrogen species") - pmid:28391535 + pubmed:27794524 - a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(MESH:"nicotinic receptor alpha4beta2")) + a(MESH:Astrocytes) directlyIncreases a(CHEBI:"nitric oxide") - pmid:28391535 + pubmed:27794524 - a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(MESH:"nicotinic receptor alpha3beta4")) + a(MESH:Astrocytes) association a(PUBCHEM:54677946) - pmid:28391535 + pubmed:30967783 - a(MESH:"Dihydro-beta-Erythroidine") decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + act(a(MESH:Astrocytes)) negativeCorrelation p(HGNC:TNF) - pmid:19721446 + pubmed:30967783 - a(CHEBI:varenicline) increases path(MESH:"Smoking Cessation") + act(a(MESH:Astrocytes)) negativeCorrelation p(HGNC:C1QA) - pmid:19721446 + pubmed:30967783 - a(CHEBI:varenicline) increases act(p(HBP:"alpha-4 beta-2 nAChR")) + a(MESH:Astrocytes) positiveCorrelation act(a(MESH:Neurons)) - pmid:19721446 + pubmed:30967783 - a(CHEBI:varenicline) increases act(p(HGNC:CHRNA7)) + a(MESH:Astrocytes) positiveCorrelation act(a(MESH:Oligodendroglia)) - pmid:28391535 + pubmed:19126755 - a(CHEBI:varenicline) increases act(a(MESH:"nicotinic receptor alpha4beta2")) + a(MESH:Astrocytes) increases a(CHEBI:"kynurenic acid") - pmid:28391535 + pubmed:23383175 - a(CHEBI:varenicline) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + a(MESH:Astrocytes) positiveCorrelation a(MESH:Microglia) - + + + pubmed:23383175 + + a(MESH:Astrocytes) negativeCorrelation a(GO:"myelin sheath") + @@ -85808,3782 +86375,3968 @@

Statements

- pmid:19721446 + pubmed:30108137 - complex(p(HGNC:CHRNA4), p(HGNC:CHRNA6), p(HGNC:CHRNB2), p(HGNC:CHRNB3)) association a(MESH:"Dopaminergic Neurons") + a(MESH:Astrocytes) increases act(a(MESH:Lysosomes)) - - - - - - - pmid:19721446 + pubmed:28803412 - complex(p(HGNC:CHRNA6), p(HGNC:CHRNB2), p(HGNC:CHRNB3)) association a(MESH:"Dopaminergic Neurons") + a(MESH:Astrocytes) increases deg(a(CONSO:CONSO00093)) - + + + pubmed:30108137 + + act(a(MESH:Astrocytes)) increases tloc(a(CONSO:"Tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + - pmid:19721446 + pubmed:26195256 - complex(p(HGNC:CHRNA6), p(HGNC:CHRNB2)) association a(MESH:"Dopaminergic Neurons") + a(MESH:Astrocytes) increases tloc(p(MESH:Endopeptidases), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:19721446 + pubmed:26195256 - g(HGNC:CHRNA5) association path(MESH:"Lung Neoplasms") + a(MESH:Astrocytes) decreases a(CHEBI:amyloid-beta, loc(MESH:"Extracellular Fluid")) - pmid:19721446 + pubmed:26195256 - g(HGNC:CHRNA3) association path(MESH:"Lung Neoplasms") + a(MESH:Astrocytes) increases deg(a(CHEBI:amyloid-beta)) - pmid:19721446 + pubmed:26195256 - g(HGNC:CHRNB4) association path(MESH:"Lung Neoplasms") + act(a(MESH:Astrocytes)) decreases a(CHEBI:amyloid-beta) - pmid:19721446 + pubmed:26195256 - path(MESH:Recurrence) association p(HGNC:CHRNA3) + act(a(MESH:Astrocytes)) increases a(MESH:Cytokines) - pmid:19721446 + pubmed:18562203 - path(MESH:Recurrence) association p(HGNC:CHRNB4) + act(a(MESH:Astrocytes)) association p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 18)) - pmid:19721446 + pubmed:18562203 - a(CHEBI:fluoxetine) decreases a(CHEBI:monoamine) + act(a(MESH:Astrocytes)) association path(MESH:"Plaque, Amyloid") - pmid:19721446 + pubmed:27314526 - a(CHEBI:fluoxetine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + a(MESH:Astrocytes) increases p(HGNC:NLRP3) - pmid:19721446 + pubmed:27314526 - a(CHEBI:sertraline) decreases a(CHEBI:monoamine) + a(MESH:Astrocytes) increases p(HGNC:TLR4) - pmid:19721446 + pubmed:27314526 - a(CHEBI:sertraline) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + a(MESH:Astrocytes) increases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:19721446 + pubmed:27794524 - a(CHEBI:paroxetine) decreases a(CHEBI:monoamine) + a(MESH:"Free Radical Scavengers") directlyDecreases a(CHEBI:"reactive oxygen species") - pmid:19721446 + pubmed:27794524 - a(CHEBI:paroxetine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + a(MESH:"Free Radical Scavengers") directlyDecreases a(CHEBI:"reactive nitrogen species") - pmid:19721446 + pubmed:27794524 - a(CHEBI:nefazodone) decreases a(CHEBI:monoamine) + a(MESH:"Free Radical Scavengers") causesNoChange path(MESH:Immunity) - pmid:19721446 + pubmed:27794524 - a(CHEBI:nefazodone) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + act(p(MESH:"Electron Transport Chain Complex Proteins")) directlyDecreases tloc(a(CHEBI:"reactive oxygen species"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:19721446 + pubmed:27794524 - a(CHEBI:nisoxetine) decreases a(CHEBI:monoamine) + p(MESH:"Molecular Motor Proteins") directlyIncreases tloc(p(MESH:Mitochondria), fromLoc(GO:"cell body"), toLoc(GO:axon)) - pmid:19721446 + pubmed:27794524 - a(CHEBI:nisoxetine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + a(CHEBI:"iron(3+)", loc(GO:"extracellular space")) increases a(CHEBI:"iron(2+)", loc(GO:"extracellular space")) - pmid:19721446 + pubmed:30837838 - a(CHEBI:nomifensine) decreases a(CHEBI:monoamine) + a(CHEBI:"iron(3+)") association path(MESH:"Amyotrophic Lateral Sclerosis") - pmid:19721446 + pubmed:30837838 - a(CHEBI:nomifensine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + a(CHEBI:"iron(3+)") causesNoChange a(MESH:"Inclusion Bodies") - pmid:19721446 + pubmed:30837838 - a(CHEBI:vanoxerine) decreases a(CHEBI:monoamine) + a(CHEBI:"iron(3+)") causesNoChange path(MESH:"Protein Aggregation, Pathological") - pmid:19721446 + pubmed:27794524 - a(CHEBI:vanoxerine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + a(CHEBI:"iron(2+)", loc(GO:"extracellular space")) directlyIncreases a(CHEBI:"reactive oxygen species") + + + + + + - pmid:19721446 + pubmed:27794524 - a(MESH:"5-(2-azetidinylmethoxy)-2-chloropyridine") increases act(p(HBP:"alpha-4 beta-2 nAChR")) + a(CHEBI:"sodium(1+)", loc(GO:axon)) directlyIncreases a(CHEBI:"calcium(2+)", loc(GO:axon)) - pmid:19721446 + pubmed:30837838 - a(MESH:"5-(2-azetidinylmethoxy)-2-chloropyridine") association path(MESH:Vomiting) + a(CHEBI:"sodium(1+)") increases bp(GO:"neuron death") - pmid:19721446 + pubmed:27794524 - a(MESH:"5-(2-azetidinylmethoxy)-2-chloropyridine") association path(MESH:Nausea) + p(MESH:"Sodium-Calcium Exchanger") directlyDecreases a(CHEBI:"calcium(2+)", loc(GO:axon)) - pmid:19721446 + pubmed:27794524 - a(MESH:"5-(2-azetidinylmethoxy)-2-chloropyridine") increases act(complex(p(HGNC:CHRNA3), p(HGNC:CHRNB4))) + p(MESH:"Sodium-Calcium Exchanger") directlyDecreases a(CHEBI:"calcium(2+)", loc(GO:"extracellular space")) - pmid:19721446 + pubmed:27794524 - a(MESH:"3-(5,6-dichloropyridin-3-yl)-3,6-diazabicyclo(3.2.0)heptane") increases act(p(HBP:"alpha-4 beta-2 nAChR")) + p(MESH:"Sodium-Calcium Exchanger") directlyIncreases a(CHEBI:"sodium(1+)", loc(GO:axon)) - - - pmid:19721446 + pubmed:27794524 - complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) association a(MESH:Conotoxins) + a(MESH:Calpain) directlyIncreases path(MESH:"Nerve Degeneration") - pmid:19721446 + pubmed:27794524 - complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) increases act(a(MESH:Lymphocytes)) + a(MESH:Calpain) directlyIncreases deg(p(MESH:"Cytoskeletal Proteins")) - pmid:28901280 + pubmed:27794524 - complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) increases p(MESH:"Receptors, Nicotinic") + a(MESH:Phospholipases) directlyIncreases path(MESH:"Nerve Degeneration") - pmid:28901280 + pubmed:27794524 - path(MESH:Pain) association p(MESH:"Receptors, Nicotinic") + a(MESH:Phospholipases) directlyIncreases deg(p(MESH:"Cytoskeletal Proteins")) - pmid:22040696 + pubmed:23038257 - p(FPLX:Cyclophilin) increases p(HGNC:CHRNA7) + p(MESH:"Cytoskeletal Proteins") association p(HGNC:CHRNA4) - pmid:22040696 + pubmed:29428175 - p(FPLX:"p14_3_3") increases p(FPLX:CHRN) + p(MESH:"Cytoskeletal Proteins") regulates bp(GO:"vesicle-mediated transport") - pmid:22040696 + pubmed:27794524 - p(HGNC:HSPA5) increases p(FPLX:CHRN) + p(MESH:"Microtubule Proteins", pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation a(CHEBI:"calcium(2+)", loc(GO:axon)) - pmid:22040696 + pubmed:27794524 - p(HGNC:CANX) increases p(FPLX:CHRN) + p(MESH:"Microtubule Proteins", pmod(go:0006468 ! "protein phosphorylation")) regulates path(MESH:Cytoskeleton) + + - pmid:22040696 + pubmed:27794524 - complex(GO:"proteasome complex") regulates p(FPLX:CHRN) + p(MESH:"Neurofilament Proteins", pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation a(CHEBI:"calcium(2+)", loc(GO:axon)) - pmid:22040696 + pubmed:27794524 - complex(GO:"proteasome complex") increases bp(GO:"modulation of chemical synaptic transmission") + p(MESH:"Neurofilament Proteins", pmod(go:0006468 ! "protein phosphorylation")) regulates path(MESH:Cytoskeleton) - pmid:22040696 + pubmed:28148553 - complex(GO:"proteasome complex") regulates p(HGNC:RIC3) + p(MESH:"Neurofilament Proteins", pmod(go:0006468 ! "protein phosphorylation"), loc(MESH:Axons)) association act(a(MESH:Axons)) - pmid:29758300 + pubmed:28148553 - complex(GO:"proteasome complex") association p(HGNC:MAPT, pmod(Ph)) + p(MESH:"Neurofilament Proteins", pmod(go:0006468 ! "protein phosphorylation")) association path(DOID:tauopathy) + + - pmid:29758300 + pubmed:27794524 - complex(GO:"proteasome complex") increases deg(p(HGNC:SNCA)) + p(MESH:"Sodium-Potassium-Exchanging ATPase") regulates bp(GO:"membrane repolarization") - pmid:14556719 + pubmed:27794524 - complex(GO:"proteasome complex") increases deg(p(MESH:Proteins, pmod(GO:"protein K48-linked ubiquitination"))) + p(HGNC:TRPM4) decreases bp(GO:"positive regulation of calcium ion import") - pmid:14556719 + pubmed:27794524 - complex(GO:"proteasome complex") increases deg(p(MESH:Proteins, pmod(GO:"protein K63-linked ubiquitination"))) + bp(GO:"positive regulation of calcium ion import") increases path(CONSO:Excitotoxicity) - pmid:14556719 + pubmed:27794524 - complex(GO:"proteasome complex") increases deg(complex(p(HGNC:OAZ1), p(HGNC:ODC1))) + p(MESH:"Calcium Channels") decreases bp(GO:"positive regulation of calcium ion import") - pmid:14556719 + pubmed:27794524 - complex(GO:"proteasome complex") increases a(CHEBI:peptide) + p(HGNC:ASIC1) decreases bp(GO:"positive regulation of calcium ion import") - - - - - pmid:14556719 + pubmed:27794524 - complex(GO:"proteasome complex") regulates bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + act(p(MESH:"Receptors, Glutamate")) increases path(CONSO:Excitotoxicity) - pmid:14556719 + pubmed:29428175 - complex(GO:"proteasome complex") increases deg(a(CHEBI:"amyloid-beta")) + p(MESH:"Receptors, Glutamate", loc(GO:"postsynaptic membrane")) association bp(MESH:"Neuronal Plasticity") - pmid:22908190 + pubmed:29428175 - act(complex(GO:"proteasome complex")) negativeCorrelation a(CHEBI:"amyloid-beta") + p(MESH:"Receptors, Glutamate", loc(GO:"postsynaptic membrane")) association bp(GO:"synaptic transmission, GABAergic") - pmid:14556719 + pubmed:27794524 - act(complex(GO:"proteasome complex")) negativeCorrelation bp(GO:aging) + p(MESH:"Gonadal Steroid Hormones") directlyDecreases path(MESH:Atrophy) - pmid:22908190 + pubmed:27794524 - act(complex(GO:"proteasome complex")) negativeCorrelation bp(GO:aging) + p(MESH:Testosterone) directlyIncreases path(CONSO:Excitotoxicity) - pmid:22908190 + pubmed:27794524 - act(complex(GO:"proteasome complex")) negativeCorrelation bp(GO:aging) + p(MESH:Testosterone) decreases path(MESH:Remyelination) - pmid:14556719 + pubmed:27794524 - act(complex(GO:"proteasome complex")) negativeCorrelation p(HGNC:SOD1, var("?")) + a(PUBCHEM:65065) association path(MESH:"Nerve Degeneration") - pmid:14556719 + pubmed:27794524 - act(complex(GO:"proteasome complex")) decreases bp(GO:autophagy) + a(PUBCHEM:4212) decreases path(MESH:"Multiple Sclerosis") - pmid:18930136 + pubmed:27794524 - act(complex(GO:"proteasome complex")) negativeCorrelation bp(GO:autophagy) + a(PUBCHEM:4212) increases path(MESH:Cardiomyopathies) - pmid:14556719 + pubmed:27794524 - act(complex(GO:"proteasome complex")) decreases p(HGNC:HTT, frag("?")) + a(PUBCHEM:4212) increases path(MESH:"Leukemia, Promyelocytic, Acute") - pmid:22908190 + pubmed:27956442 - complex(GO:"proteasome complex") increases deg(p(MESH:Proteins, pmod(Ub))) + a(PUBCHEM:4212) directlyDecreases path(MESH:"Multiple Sclerosis, Chronic Progressive") - pmid:22908190 + pubmed:27956442 - complex(GO:"proteasome complex") increases deg(p(MESH:Proteins, pmod(UbK48))) + a(PUBCHEM:4212) increases path(MESH:"Arrhythmias, Cardiac") - pmid:22908190 + pubmed:27956442 - act(complex(GO:"proteasome complex")) negativeCorrelation a(HBP:"paired helical filaments") + a(PUBCHEM:4212) increases path(MESH:"Leukemia, Myeloid, Acute") - pmid:22908190 + pubmed:27794524 - act(complex(GO:"proteasome complex")) negativeCorrelation a(GO:"neurofibrillary tangle") + a(PUBCHEM:363907627) decreases path(MESH:"Developmental Disabilities") - pmid:22908190 + pubmed:27794524 - act(complex(GO:"proteasome complex")) negativeCorrelation complex(a(GO:"proteasome regulatory particle"), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) + a(PUBCHEM:363907627) directlyDecreases path(MESH:"Multiple Sclerosis, Relapsing-Remitting") - pmid:22908190 + pubmed:27794524 - complex(GO:"proteasome complex") increases deg(p(FPLX:PKA, pmod(Ub))) + a(PUBCHEM:47206937) directlyIncreases bp(GO:"antibody-dependent cellular cytotoxicity") - pmid:22908190 + pubmed:27794524 - complex(GO:"proteasome complex") increases deg(p(HGNC:MAPT)) + a(PUBCHEM:47206937) decreases path(MESH:"Multiple Sclerosis, Chronic Progressive") - pmid:22908190 + pubmed:27956442 - complex(GO:"proteasome complex") increases deg(p(HGNC:MAPT)) + a(PUBCHEM:47206937) decreases path(MESH:"Multiple Sclerosis, Chronic Progressive") - pmid:22908190 + pubmed:27956442 - act(complex(GO:"proteasome complex")) negativeCorrelation p(HGNC:MAPT) + a(PUBCHEM:47206937) directlyDecreases p(HGNC:MS4A1) - pmid:26751493 + pubmed:27794524 - act(complex(GO:"proteasome complex")) negativeCorrelation p(HGNC:MAPT) + bp(GO:"antibody-dependent cellular cytotoxicity") decreases a(MESH:B-Lymphocytes) - pmid:17954934 + pubmed:27794524 - act(complex(GO:"proteasome complex")) increases deg(p(HGNC:MAPT)) + a(PUBCHEM:11388331) directlyDecreases a(CHEBI:"reactive oxygen species", loc(GO:mitochondrion)) - pmid:24457024 + pubmed:27794524 - complex(GO:"proteasome complex") regulates complex(a(MESH:Proteins), a(MESH:Ubiquitin)) + a(PUBCHEM:11388331) causesNoChange path(MESH:Inflammation) - pmid:18930136 + pubmed:27794524 - act(complex(GO:"proteasome complex")) decreases path(HBP:Neurodegeneration) + a(PUBCHEM:11388331) directlyDecreases path(MESH:"Nerve Degeneration") - pmid:18930136 + pubmed:27794524 - act(complex(GO:"proteasome complex")) decreases p(HGNC:SQSTM1) + a(PUBCHEM:3686) isA a(MESH:Antioxidants) - pmid:18930136 + pubmed:27794524 - act(complex(GO:"proteasome complex")) decreases r(HGNC:SQSTM1) + a(PUBCHEM:3686) directlyDecreases path(MESH:"Optic Atrophy, Hereditary, Leber") - pmid:30116051 + pubmed:27794524 - complex(GO:"proteasome complex") increases deg(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) + a(PUBCHEM:3686) causesNoChange path(MESH:"Encephalomyelitis, Autoimmune, Experimental") - pmid:30116051 + pubmed:27794524 - complex(GO:"proteasome complex") increases deg(a(HBP:"Tau oligomers")) + a(PUBCHEM:3878) decreases path(MESH:"Neurologic Manifestations") - pmid:17954934 + pubmed:27794524 - act(complex(GO:"proteasome complex")) isA complex(GO:"proteasome complex") + a(PUBCHEM:3878) causesNoChange path(MESH:"Multiple Sclerosis") - pmid:17954934 + pubmed:27794524 - act(complex(GO:"proteasome complex")) negativeCorrelation p(HGNC:BAG1) + a(PUBCHEM:1775) decreases path(MESH:"Neurologic Manifestations") - pmid:26041011 + pubmed:27794524 - act(complex(GO:"proteasome complex")) decreases a(HBP:"Tau aggregates") + a(PUBCHEM:2554) decreases path(MESH:"Neurologic Manifestations") - pmid:27181519 + pubmed:27794524 - act(complex(GO:"proteasome complex")) negativeCorrelation complex(GO:"cytoplasmic stress granule") + a(PUBCHEM:16231) directlyDecreases p(HGNC:ASIC1) - pmid:27181519 + pubmed:27794524 - complex(GO:"proteasome complex") decreases complex(GO:"cytoplasmic stress granule") + a(PUBCHEM:16231) directlyDecreases p(HGNC:TRPM4) - pmid:27181519 + pubmed:27794524 - complex(GO:"proteasome complex") increases deg(p(HGNC:TARDBP)) + a(PUBCHEM:16231) increases path(MESH:Neuroprotection) - - - + + + pubmed:27794524 + + a(PUBCHEM:16231) increases a(MESH:Oligodendroglia) + - + + + pubmed:27794524 + + a(PUBCHEM:16231) decreases path(MESH:"Nerve Degeneration") + - + + + pubmed:27794524 + + a(PUBCHEM:3488) directlyDecreases p(HGNC:ASIC1) + - + + + pubmed:27794524 + + a(PUBCHEM:3488) directlyDecreases p(HGNC:TRPM4) + - + + + pubmed:27794524 + + a(PUBCHEM:3488) increases path(MESH:Neuroprotection) + - pmid:22040696 + pubmed:27794524 - composite(p(HGNC:HTR3A), p(HGNC:RIC3)) decreases surf(p(HGNC:HTR3A)) + a(PUBCHEM:3488) increases a(MESH:Oligodendroglia) - - - + + + pubmed:27794524 + + a(PUBCHEM:3488) decreases path(MESH:"Nerve Degeneration") + - pmid:22040696 + pubmed:27794524 - p(UNIPROT:P34371) increases act(p(FPLX:CHRN)) + a(PUBCHEM:3272524) decreases path(MESH:"Nerve Degeneration") - pmid:22040696 + pubmed:27794524 - p(FPLX:CHRN, pmod(Ph, Tyr)) decreases act(p(FPLX:CHRN)) + a(PUBCHEM:3272524) increases a(MESH:Oligodendroglia) - + + + pubmed:27794524 + + a(PUBCHEM:3272524) decreases deg(a(MESH:Axons)) + - pmid:22040696 + pubmed:22372633 - complex(p(FPLX:CHRN), p(FPLX:SRC)) increases bp(GO:"catecholamine secretion") + a(MESH:Axons) negativeCorrelation path(MESH:"Muscle Denervation") - + + + pubmed:12428809 + + a(MESH:Axons) negativeCorrelation a(MESH:"Intermediate Filaments") + - pmid:22040696 + pubmed:28148553 - complex(p(FPLX:CHRN), p(HGNC:FYN)) increases bp(GO:"catecholamine secretion") + act(a(MESH:Axons)) association p(MESH:"Neurofilament Proteins", pmod(go:0006468 ! "protein phosphorylation"), loc(MESH:Axons)) - + + + pubmed:27671637 + + a(MESH:Axons) positiveCorrelation p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) + - pmid:22040696 + pubmed:27794524 - complex(p(HGNC:CHRNA7), p(HGNC:FYN)) increases act(p(FPLX:PI3K)) + p(HGNC:GDNF) association bp(GO:"axon development") - + + + pubmed:27794524 + + bp(GO:"axon development") association p(HGNC:GDNF) + - pmid:22040696 + pubmed:27794524 - complex(p(HGNC:CHRNA7), p(HGNC:JAK2)) increases act(p(FPLX:PI3K)) + bp(GO:"axon development") association p(HGNC:IGF1) - pmid:22040696 + pubmed:27794524 - p(HGNC:CHRNA7, pmod(Ph, Tyr)) decreases act(p(HGNC:CHRNA7)) + bp(GO:"axon development") association p(HGNC:BDNF) - pmid:21787755 + pubmed:30061532 - bp(GO:"maintenance of synapse structure") association a(HBP:"alpha-7-containing nAChR") + bp(GO:"axon development") association p(HGNC:DISC1) - pmid:22040696 + pubmed:30061532 - act(a(MESH:"SNARE Proteins")) increases tloc(p(HGNC:CHRNA7), fromLoc(GO:"cell surface"), toLoc(GO:endosome)) + bp(GO:"axon development") association p(HGNC:DPYSL2) - pmid:22040696 + pubmed:27794524 - act(a(MESH:"SNARE Proteins")) causesNoChange surf(p(HGNC:CHRNA7)) + a(PUBCHEM:54677946) isA a(MESH:"Neuroprotective Agents") - pmid:22040696 + pubmed:27794524 - p(HGNC:CHRNA7, var("p.Leu335Ala")) decreases surf(p(HGNC:CHRNA7)) + a(PUBCHEM:54677946) association a(MESH:Microglia) - pmid:22040696 + pubmed:27794524 - p(HGNC:CHRNA7, var("p.Leu336Ala")) decreases surf(p(HGNC:CHRNA7)) + a(PUBCHEM:54677946) association a(MESH:Astrocytes) - pmid:22040696 + pubmed:30740335 - p(HGNC:CHRNA7, var("p.Leu343Ala")) decreases surf(p(HGNC:CHRNA7)) + a(MESH:"Neuroprotective Agents") association a(PUBCHEM:9561611) - pmid:22040696 + pubmed:27794524 - r(HGNC:RIC3) positiveCorrelation path(MESH:Schizophrenia) + a(PUBCHEM:3671) directlyIncreases a(MESH:"Nerve Growth Factors") - pmid:22040696 + pubmed:27794524 - r(HGNC:RIC3) positiveCorrelation path(MESH:"Bipolar Disorder") + a(PUBCHEM:3671) directlyDecreases bp(GO:"glial cell activation") - pmid:22040696 + pubmed:27794524 - path(MESH:"Bipolar Disorder") positiveCorrelation r(HGNC:RIC3) + bp(GO:"myelin maintenance") negativeCorrelation path(MESH:"Oxidative Stress") - pmid:22040696 + pubmed:27794524 - path(MESH:"Bipolar Disorder") negativeCorrelation act(p(HGNC:RIC3), ma(chap)) + a(PUBCHEM:10074640) directlyDecreases p(MESH:"Receptor Protein-Tyrosine Kinases") - pmid:22040696 + pubmed:27794524 - bp(GO:"response to ischemia") increases path(MESH:"Renal Insufficiency") + a(PUBCHEM:10074640) regulates bp(GO:"mast cell degranulation") - + + + pubmed:27794524 + + a(PUBCHEM:10074640) regulates bp(GO:"nitric oxide mediated signal transduction") + - pmid:18174175 + pubmed:27794524 - complex(a(CHEBI:epibatidine), a(HBP:"alpha-3 beta-2 nAChR")) increases act(a(HBP:"alpha-3 beta-2 nAChR")) + a(PUBCHEM:10074640) regulates bp(GO:"dendritic cell homeostasis") - + + + pubmed:27794524 + + p(HGNC:LINGO1) directlyDecreases bp(GO:"oligodendrocyte differentiation") + - pmid:26837465 + pubmed:27794524 - p(HGNC:ESR1) association complex(GO:"neurofibrillary tangle") + p(HGNC:LINGO1) directlyDecreases bp(GO:myelination) - pmid:26837465 + pubmed:27794524 - p(HGNC:ESR1) association complex(GO:"neurofibrillary tangle") + p(HGNC:LINGO1) positiveCorrelation path(MESH:"Multiple Sclerosis") - pmid:26837465 + pubmed:27794524 - p(HGNC:ESR1) association p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + a(PUBCHEM:310264704) directlyDecreases p(HGNC:LINGO1) - + + + pubmed:27956442 + + a(MESH:"Motor Neurons") association path(MESH:"Multiple Sclerosis") + - pmid:21787755 + pubmed:30688256 - bp(GO:"neuron projection maintenance") association a(HBP:"alpha-7-containing nAChR") + a(MESH:"Motor Neurons") decreases path(MESH:"Amyotrophic Lateral Sclerosis") - + + + pubmed:28148553 + + a(MESH:"Motor Neurons") negativeCorrelation p(HGNC:MAPT, var("p.Pro301Ser")) + - pmid:21787755 + pubmed:27956442 - a(HBP:AβOs) association path(MESH:"Tobacco Use Disorder") + path(MESH:Sensation) association path(MESH:"Multiple Sclerosis") - pmid:21787755 + pubmed:27956442 - a(HBP:AβOs) association path(MESH:"Alzheimer Disease") + path(MESH:"Autonomic Nervous System") association path(MESH:"Multiple Sclerosis") - pmid:21787755 + pubmed:27956442 - a(HBP:AβOs) association path(MESH:Epilepsy) + path(MESH:"Optic Neuritis") association path(MESH:"Multiple Sclerosis") - pmid:22908190 + pubmed:27956442 - a(HBP:AβOs) decreases act(a(GO:synapse)) + path(MESH:"Body Temperature Changes") association path(MESH:"Multiple Sclerosis") - pmid:22908190 + pubmed:27956442 - a(HBP:AβOs) decreases bp(GO:"long-term synaptic potentiation") + path(NCIT:C28314) association path(MESH:"Multiple Sclerosis") - pmid:22908190 + pubmed:27956442 - a(HBP:AβOs) decreases bp(GO:learning) + path(MESH:"Central Nervous System") negativeCorrelation path(MESH:"Demyelinating Diseases") - pmid:22908190 + pubmed:27956442 - a(HBP:AβOs) decreases bp(GO:memory) + bp(GO:"transport across blood-brain barrier") directlyIncreases path(NCIT:C20613) - pmid:22908190 + pubmed:27956442 - a(HBP:AβOs) increases bp(GO:"long-term synaptic depression") + bp(GO:"transport across blood-brain barrier") directlyIncreases bp(GO:"microglial cell activation") - pmid:22908190 + pubmed:27956442 - a(HBP:AβOs) decreases bp(GO:"L-glutamate import") + bp(GO:"transport across blood-brain barrier") directlyIncreases path(MESH:"Oxidative Stress") - pmid:22908190 + pubmed:27956442 - a(HBP:AβOs) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + bp(GO:"transport across blood-brain barrier") directlyIncreases path(MESH:"Mitochondrial Diseases") - pmid:22908190 + pubmed:27956442 - a(HBP:AβOs) increases deg(a(MESH:Neurites)) + bp(GO:"transport across blood-brain barrier") negativeCorrelation path(MESH:"Energy Metabolism") - pmid:22908190 + pubmed:27956442 - a(HBP:AβOs) decreases act(complex(GO:"proteasome complex")) + path(NCIT:C20613) directlyIncreases path(MESH:Inflammation) - pmid:28528849 + pubmed:27956442 - a(HBP:AβOs) decreases a(MESH:"Dendritic Spines") + path(MESH:"Spinal Cord Diseases") increases path(EFO:"movement disorder") - + + + pubmed:27956442 + + path(MESH:"Spinal Cord Diseases") directlyIncreases path(MESH:"Paraparesis, Spastic") + - pmid:21787755 + pubmed:27956442 - a(HBP:"alpha-4 beta-4 nAChR") association path(MESH:"Tobacco Use Disorder") + path(MESH:"Paraparesis, Spastic") directlyIncreases path(MESH:"Diffuse Axonal Injury") - + + + pubmed:27956442 + + path(MESH:"Infectious Mononucleosis") positiveCorrelation path(MESH:"Multiple Sclerosis") + - + + + pubmed:27956442 + + a(CHEBI:6-methylprednisolone) directlyDecreases path(MESH:"Multiple Sclerosis, Relapsing-Remitting") + - pmid:21787755 + pubmed:27956442 - a(HBP:"alpha-6-containing nAChR") association path(MESH:Pleasure) + path(MESH:"Plasma Exchange") directlyDecreases path(MESH:"Multiple Sclerosis, Relapsing-Remitting") - pmid:21787755 + pubmed:27956442 - a(HBP:"alpha-6-containing nAChR") association path(MESH:Reward) + path(MESH:"Physical Therapy Modalities") decreases path(MESH:"Multiple Sclerosis, Relapsing-Remitting") - pmid:21787755 + pubmed:26445701 - a(HBP:"alpha-6-containing nAChR") association path(MESH:Affect) + a(MESH:"Cell Adhesion Molecules") increases bp(MESH:"Transendothelial and Transepithelial Migration") - pmid:21787755 + pubmed:27956442 - a(HBP:"alpha-6-containing nAChR") regulates sec(a(CHEBI:"gamma-aminobutyric acid")) + path(MESH:"JC Virus") increases path(MESH:"Leukoencephalopathy, Progressive Multifocal") - pmid:21787755 + pubmed:27956442 - a(HBP:"alpha-6-containing nAChR") association path(MESH:"Tobacco Use Disorder") + a(PUBCHEM:2265) causesNoChange path(MESH:"Multiple Sclerosis, Chronic Progressive") - pmid:21787755 + pubmed:27956442 - a(HBP:"alpha-6-containing nAChR") regulates bp(GO:"neurotransmitter secretion") + a(PUBCHEM:5284373) causesNoChange path(MESH:"Multiple Sclerosis, Chronic Progressive") - pmid:21787755 + pubmed:27956442 - path(MESH:Pleasure) association a(HBP:"alpha-6-containing nAChR") + a(PUBCHEM:44151255) causesNoChange path(MESH:"Multiple Sclerosis, Chronic Progressive") - pmid:21787755 + pubmed:27956442 - path(MESH:Reward) association a(HBP:"alpha-6-containing nAChR") + a(MESH:Immunoglobulins) causesNoChange path(MESH:"Multiple Sclerosis, Chronic Progressive") - pmid:21787755 + pubmed:27956442 - path(MESH:Reward) association r(HGNC:CHRNA6) + a(PUBCHEM:20279) causesNoChange path(MESH:"Multiple Sclerosis, Chronic Progressive") - pmid:21787755 + pubmed:27956442 - path(MESH:Reward) association p(HGNC:CHRNA6) + a(MESH:"Immunologic Factors") causesNoChange path(MESH:"Multiple Sclerosis, Chronic Progressive") - pmid:28901280 + pubmed:27956442 - path(MESH:Reward) association p(MESH:"Receptors, Nicotinic") + a(PUBCHEM:44599207) regulates p(HGNCGENEFAMILY:"Sphingosine 1-phosphate receptors") - pmid:21787755 + pubmed:27956442 - path(MESH:Affect) association a(HBP:"alpha-6-containing nAChR") + a(PUBCHEM:44599207) decreases path(MESH:"Multiple Sclerosis, Chronic Progressive") - pmid:21787755 + pubmed:27956442 - a(MESH:"neuronal bungarotoxin") decreases act(a(HBP:"alpha-3 beta-2 nAChR")) + a(PUBCHEM:47206399) increases path(MESH:Headache) - pmid:21787755 + pubmed:27956442 - a(MESH:"neuronal bungarotoxin") decreases act(a(HBP:"alpha-6-containing nAChR")) + a(PUBCHEM:47206399) increases path(MESH:Lymphopenia) - pmid:21787755 + pubmed:27956442 - a(MESH:"alpha-conotoxin PnIA") decreases act(a(HBP:"alpha-3 beta-2 nAChR")) + a(PUBCHEM:47206399) increases path(MESH:"Sleep Initiation and Maintenance Disorders") - pmid:21787755 + pubmed:27956442 - a(MESH:"alpha-conotoxin PnIA") decreases act(a(HBP:"alpha-6-containing nAChR")) + a(PUBCHEM:47206399) increases path(MESH:Diarrhea) - pmid:21787755 + pubmed:27956442 - bp(MESH:"Drug Interactions") association r(HGNC:CHRNA6) + a(PUBCHEM:47206399) increases path(MESH:Nausea) - pmid:21787755 + pubmed:27956442 - bp(MESH:"Drug Interactions") association p(HGNC:CHRNA6) + a(PUBCHEM:47206399) increases path(MESH:Vomiting) - + + + pubmed:27956442 + + a(PUBCHEM:47206399) increases path(MESH:Depression) + - pmid:28901280 + pubmed:27956442 - complex(a(MESH:Acetylcholine), p(MESH:"Receptors, Nicotinic")) increases act(a(MESH:"Peripheral Nervous System")) + a(PUBCHEM:47206399) increases path(MESH:Alopecia) - pmid:28901280 + pubmed:27956442 - complex(a(MESH:Acetylcholine), p(MESH:"Receptors, Nicotinic")) increases tloc(a(MESH:Sodium), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + a(PUBCHEM:47206399) increases path(MESH:"Thyroid Diseases") - pmid:28901280 + pubmed:18986241 - complex(a(MESH:Acetylcholine), p(MESH:"Receptors, Nicotinic")) increases tloc(a(CHEBI:"calcium cation"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + path(MESH:"Sleep Initiation and Maintenance Disorders") association a(MESH:"Cholinesterase Inhibitors") - pmid:28901280 + pubmed:26195256 - complex(a(MESH:Acetylcholine), p(MESH:"Receptors, Nicotinic")) increases tloc(a(CHEBI:"potassium(1+)"), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) + path(MESH:"Sleep Initiation and Maintenance Disorders") increases path(MESH:"Alzheimer Disease") - + + + pubmed:26195256 + + path(MESH:"Sleep Initiation and Maintenance Disorders") increases path(MESH:"Alzheimer Disease") + - pmid:28901280 + pubmed:19721446 - complex(a(MESH:Nicotine), p(MESH:"Receptors, Nicotinic"), loc(MESH:Brain)) decreases path(MESH:Anxiety) + path(MESH:Vomiting) association a(MESH:"5-(2-azetidinylmethoxy)-2-chloropyridine") - pmid:28901280 + pubmed:27956442 - a(MESH:Nicotine) decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) + a(PUBCHEM:172232576) increases path(MESH:Headache) - pmid:28901280 + pubmed:27956442 - a(MESH:Nicotine) increases complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) + a(PUBCHEM:172232576) increases path(MESH:Lymphopenia) - pmid:28901280 + pubmed:27956442 - a(MESH:Nicotine) decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) + a(PUBCHEM:172232576) increases path(MESH:"Sleep Initiation and Maintenance Disorders") - pmid:28901280 + pubmed:27956442 - a(MESH:Nicotine) decreases a(MESH:Neurons) + a(PUBCHEM:172232576) increases path(MESH:Diarrhea) - pmid:28901280 + pubmed:27956442 - a(MESH:Nicotine) decreases p(MESH:"Receptors, Nicotinic") + a(PUBCHEM:172232576) increases path(MESH:Nausea) - pmid:28901280 + pubmed:27956442 - a(MESH:Nicotine) increases bp(GO:"nodal receptor complex assembly") + a(PUBCHEM:172232576) increases path(MESH:Vomiting) - pmid:28901280 + pubmed:27956442 - a(MESH:Nicotine) increases act(p(MESH:"Proteasome Endopeptidase Complex")) + a(PUBCHEM:172232576) increases path(MESH:Depression) - pmid:28901280 + pubmed:27956442 - a(MESH:Nicotine) increases a(MESH:Glutamates) + a(PUBCHEM:172232576) increases path(MESH:Alopecia) - pmid:28901280 + pubmed:27956442 - a(MESH:Nicotine) increases a(MESH:Glutamates) + a(PUBCHEM:172232576) increases path(MESH:"Liver Diseases") - pmid:28901280 + pubmed:27956442 - a(MESH:Nicotine) increases p(MESH:"Receptors, GABA") + a(PUBCHEM:172232576) increases path(MESH:"Thyroid Diseases") - pmid:28901280 + pubmed:27181519 - a(MESH:Nicotine) decreases p(MESH:"Receptors, GABA") + path(MESH:"Liver Diseases") association p(HGNC:TBK1) - pmid:28901280 + pubmed:27956442 - a(MESH:Nicotine) increases bp(GO:"action potential initiation") + a(PUBCHEM:50070200) increases path(MESH:Headache) - pmid:28901280 + pubmed:27956442 - a(MESH:Nicotine) increases a(MESH:Dopamine) + a(PUBCHEM:50070200) increases path(MESH:Lymphopenia) - pmid:28901280 + pubmed:27956442 - a(MESH:Nicotine) increases a(MESH:Dopamine) + a(PUBCHEM:50070200) increases path(MESH:"Sleep Initiation and Maintenance Disorders") - pmid:28901280 + pubmed:27956442 - a(MESH:Nicotine) increases act(p(HGNC:CHRNA7)) + a(PUBCHEM:50070200) increases path(MESH:Diarrhea) - pmid:28901280 + pubmed:27956442 - a(MESH:Nicotine) decreases act(p(HGNC:CHRNA7)) + a(PUBCHEM:50070200) increases path(MESH:Nausea) - pmid:28901280 + pubmed:27956442 - a(MESH:Nicotine) increases p(MESH:"Receptors, N-Methyl-D-Aspartate") + a(PUBCHEM:50070200) increases path(MESH:Vomiting) - pmid:28901280 + pubmed:27956442 - a(MESH:Nicotine) increases bp(MESH:"Long-Term Potentiation") + a(PUBCHEM:50070200) increases path(MESH:Depression) - pmid:28901280 + pubmed:27956442 - act(a(MESH:Nicotine)) association g(DNSNP:rs16969968) + a(PUBCHEM:50070200) increases path(MESH:Alopecia) - pmid:28901280 + pubmed:27956442 - a(MESH:Nicotine) increases path(MESH:Neoplasms) + a(PUBCHEM:50070200) increases path(MESH:"Liver Diseases") - pmid:28901280 + pubmed:27956442 - a(MESH:Nicotine) causesNoChange act(complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9))) + a(PUBCHEM:50070200) increases path(MESH:"Thyroid Diseases") - pmid:28901280 + pubmed:27956442 - a(MESH:Nicotine) causesNoChange act(p(HGNC:CHRNA9)) + a(PUBCHEM:50070200) increases path(HP:Lipoatrophy) - + + + pubmed:27956442 + + a(PUBCHEM:50070200) increases path(MESH:Anxiety) + - pmid:28901280 + pubmed:27956442 - complex(a(MESH:"Receptors, Muscarinic"), a(MESH:Acetylcholine)) increases act(a(MESH:"Central Nervous System")) + a(PUBCHEM:50070200) increases path(MESH:Flushing) - pmid:28901280 + pubmed:27956442 - bp(GO:"cell-cell signaling") association a(MESH:Acetylcholine) + a(PUBCHEM:50070200) increases path(HP:Palpitations) - pmid:26751493 + pubmed:27956442 - bp(GO:"cell-cell signaling") association complex(p(HBP:"projection domain"), p(HGNC:LCK)) + a(PUBCHEM:50070200) increases path(MESH:Dyspnea) - pmid:26751493 + pubmed:27956442 - bp(GO:"cell-cell signaling") association complex(p(HBP:"projection domain"), p(HGNC:FGR)) + a(PUBCHEM:50070200) increases path(MESH:"Chest Pain") - pmid:26751493 + pubmed:26445701 - bp(GO:"cell-cell signaling") association complex(p(HBP:"projection domain"), p(HGNC:SRC)) + g(HGNC:IL2RA) positiveCorrelation path(DOID:"multiple sclerosis") - pmid:26751493 + pubmed:26445701 - bp(GO:"cell-cell signaling") association complex(p(HBP:"projection domain"), p(HGNC:GRB2)) + g(HGNC:IL7R) positiveCorrelation path(DOID:"multiple sclerosis") - pmid:26751493 + pubmed:26445701 - bp(GO:"cell-cell signaling") association complex(p(FPLX:PLC), p(HBP:"projection domain")) + path(MESH:"Vitamin D Deficiency") positiveCorrelation path(DOID:"multiple sclerosis") - pmid:26751493 + pubmed:26445701 - bp(GO:"cell-cell signaling") association complex(a(CHEBI:phosphatidylinositol), p(HBP:"projection domain")) + act(a(MESH:"Th1 Cells")) increases path(MESH:"Autoimmune Diseases") - pmid:26751493 + pubmed:26445701 - bp(GO:"cell-cell signaling") association complex(a(CHEBI:"phosphatidylinositol bisphosphate"), p(HBP:"projection domain")) + a(MESH:"Th1 Cells") increases p(HGNC:IL2) - pmid:26751493 + pubmed:26445701 - bp(GO:"cell-cell signaling") association complex(p(HBP:"projection domain"), p(HGNC:PIN1)) + a(MESH:"Th1 Cells") increases p(HGNC:TNF) - pmid:28901280 + pubmed:26445701 - bp(HBP:"cell population proliferation") association a(MESH:Acetylcholine) + a(MESH:"Th1 Cells") increases p(MESH:Interferon-gamma) - pmid:28901280 + pubmed:26445701 - bp(HBP:"cell population proliferation") association p(MESH:"Receptors, Nicotinic") + a(MESH:"Th1 Cells") association a(MESH:"Th17 Cells") - pmid:28901280 + pubmed:30967783 - bp(MESH:"Cell Movement") association a(MESH:Acetylcholine) + a(MESH:"Th1 Cells") increases p(HGNC:IFNG) - pmid:28901280 + pubmed:26445701 - bp(GO:"secretion by cell") association a(MESH:Acetylcholine) + a(MESH:Sanitation) increases path(MESH:"Autoimmune Diseases") - pmid:28901280 + pubmed:26445701 - bp(MESH:"Autocrine Communication") association a(MESH:Acetylcholine) + a(MESH:Sanitation) increases path(HP:Allergy) - pmid:28901280 + pubmed:26445701 - bp(MESH:"Paracrine Communication") association a(MESH:Acetylcholine) + act(a(MESH:"Th2 Cells")) increases path(HP:Allergy) - pmid:28901280 + pubmed:26445701 - bp(HBP:"juxtacrine signaling") association a(MESH:Acetylcholine) + a(MESH:"Th2 Cells") increases tloc(p(HGNC:IL4), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:28901280 + pubmed:26979166 - a(MESH:Erythrocytes) increases a(MESH:Acetylcholine) + a(MESH:"Th2 Cells") increases tloc(p(HGNC:IL4), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:28901280 + pubmed:30988501 - a(MESH:Erythrocytes) increases a(MESH:"Choline O-Acetyltransferase") + a(MESH:"Th2 Cells") increases act(p(HGNC:IL4)) - pmid:29626319 + pubmed:26445701 - a(MESH:Erythrocytes) increases deg(a(CHEBI:"amyloid-beta")) + a(MESH:"Th2 Cells") increases tloc(p(HGNC:IL5), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:29626319 + pubmed:26979166 - a(MESH:Erythrocytes) increases deg(a(CHEBI:"amyloid-beta")) + a(MESH:"Th2 Cells") increases tloc(p(HGNC:IL5), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:28901280 + pubmed:26445701 - a(MESH:"Epithelial Cells") increases a(MESH:Acetylcholine) + a(MESH:"Th2 Cells") increases tloc(p(HGNC:IL10), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:28901280 + pubmed:26445701 - a(MESH:"Epithelial Cells") increases a(MESH:"Choline O-Acetyltransferase") + a(MESH:"Th2 Cells") decreases act(a(MESH:"Th1 Cells")) - pmid:28901280 + pubmed:30967783 - path(MESH:Learning) association p(MESH:"Receptors, Nicotinic") + a(MESH:"Th2 Cells") association a(NCIT:C123783) - pmid:28901280 + pubmed:30988501 - bp(MESH:Analgesia) association p(MESH:"Receptors, Nicotinic") + a(MESH:"Th2 Cells") association path(MESH:"Brain Injuries") - + + + pubmed:26445701 + + a(CHEBI:"vitamin A") regulates bp(MESH:Immunity) + - + + + pubmed:27190210 + + bp(MESH:Immunity) association p(HGNC:CHRNA7) + + + + pubmed:26445701 + + a(CHEBI:salt) regulates bp(MESH:Immunity) + + - pmid:28901280 + pubmed:26445701 - p(HGNC:CHRFAM7A, loc(MESH:Oocytes)) decreases act(p(HGNC:CHRNA7, loc(MESH:Oocytes))) + a(CHEBI:salt) regulates bp(GO:"T-helper 17 cell differentiation") - pmid:28901280 + pubmed:26445701 - bp(GO:"cell differentiation") association p(MESH:"Receptors, Nicotinic") + a(CHEBI:"omega-3 unsaturated fatty acyl-CoA(4-)") regulates bp(MESH:Immunity) - pmid:28901280 + pubmed:26445701 - a(HBP:cytisine) decreases p(MESH:"Receptors, Nicotinic") + a(CHEBI:polyphenol) regulates bp(MESH:Immunity) - pmid:28901280 + pubmed:21882945 - a(HBP:cytisine) decreases act(a(MESH:Nicotine)) + a(CHEBI:polyphenol) decreases a(CONSO:"Tau aggregates") - pmid:28901280 + pubmed:21882945 - a(MESH:Carbachol) decreases p(MESH:"Receptors, Nicotinic") + a(CHEBI:polyphenol) decreases complex(p(INTERPRO:"Chaperone J-domain superfamily"), p(INTERPRO:"Heat shock protein 70 family")) - pmid:28901280 + pubmed:26445701 - a(MESH:Carbachol) decreases act(a(MESH:Nicotine)) + a(CHEBI:"sodium salt") increases path(EFO:"experimental autoimmune encephalomyelitis") - pmid:28901280 + pubmed:26445701 - a(MESH:Varenicline) decreases p(MESH:"Receptors, Nicotinic") + a(CHEBI:"sodium salt") increases path(DOID:"multiple sclerosis") - pmid:28901280 + pubmed:26445701 - a(MESH:Varenicline) decreases act(a(MESH:Nicotine)) + act(a(MESH:"CD4-Positive T-Lymphocytes")) increases deg(a(GO:"myelin sheath")) - pmid:28901280 + pubmed:26445701 - a(MESH:Mecamylamine) decreases p(MESH:"Receptors, Nicotinic") + a(MESH:"CD4-Positive T-Lymphocytes") increases path(HP:"CNS demyelination") - pmid:28901280 + pubmed:26445701 - a(MESH:Mecamylamine) decreases act(a(MESH:Nicotine)) + a(MESH:"CD4-Positive T-Lymphocytes") increases path(MESH:"Diffuse Axonal Injury") - pmid:28901280 + pubmed:26445701 - a(HBP:neurotransmitters) association p(MESH:"Receptors, Nicotinic", loc(MESH:"GABAergic Neurons")) + a(MESH:"CD4-Positive T-Lymphocytes") increases bp(GO:"positive regulation of oligodendrocyte apoptotic process") + + - pmid:28901280 + pubmed:26445701 - a(HBP:neurotransmitters) association p(MESH:"Receptors, Nicotinic", loc(MESH:"Cholinergic Neurons")) + deg(a(GO:"myelin sheath")) increases bp(MESH:"Self Tolerance") + + - pmid:28901280 + pubmed:23383175 - a(MESH:Glutamates) increases bp(MESH:"Long-Term Potentiation") + a(GO:"myelin sheath") positiveCorrelation a(CHEBI:Anatabine) - pmid:28901280 + pubmed:23383175 - a(MESH:Glutamates) increases bp(GO:"action potential initiation") + a(GO:"myelin sheath") negativeCorrelation a(MESH:Astrocytes) - pmid:27796283 + pubmed:23383175 - bp(MESH:"Long-Term Potentiation") association p(HGNC:CAMKV) + a(GO:"myelin sheath") negativeCorrelation a(MESH:Microglia) - pmid:28901280 + pubmed:23383175 - bp(HBP:"habenulo-interpeduncular pathway") increases p(MESH:"Receptors, Nicotinic") + a(GO:"myelin sheath") negativeCorrelation bp(CONSO:Astrogliosis) - pmid:28901280 + pubmed:23383175 - bp(HBP:"habenulo-interpeduncular pathway") increases p(HGNC:CHRNA3, loc(MESH:"Central Nervous System")) + a(GO:"myelin sheath") negativeCorrelation bp(CONSO:Microgliosis) - pmid:28901280 + pubmed:26445701 - bp(HBP:"habenulo-interpeduncular pathway") increases p(HGNC:CHRNB4, loc(MESH:"Central Nervous System")) + bp(MESH:"Self Tolerance") increases path(MESH:Autoimmunity) - pmid:28901280 + pubmed:26445701 - bp(HBP:"habenulo-interpeduncular pathway") increases p(HGNC:CHRNA5, loc(MESH:"Central Nervous System")) + bp(MESH:"Self Tolerance") increases act(a(MESH:T-Lymphocytes)) - pmid:28901280 + pubmed:26445701 - g(DNSNP:rs16969968) association act(a(MESH:Nicotine)) + path(HP:"Disseminated viral infection") increases bp(GO:"T cell activation") - pmid:28901280 + pubmed:26445701 - p(MGI:Chrna5) regulates act(a(MESH:Nicotine)) + path(HP:"Disseminated viral infection") increases a(MESH:Autoantigens) - pmid:28901280 + pubmed:30967783 - p(MGI:Chrna5) increases a(MESH:Nicotine) + bp(GO:"T cell activation") increases bp(GO:"microglial cell activation") - pmid:28901280 + pubmed:30967783 - p(MGI:Chrnb4) decreases act(a(MESH:Nicotine)) + bp(GO:"T cell activation") increases path(CONSO:neuroinflammation) - pmid:28901280 + pubmed:26445701 - p(MGI:Chrna2) increases a(MESH:Nicotine) + bp(MESH:"Molecular Mimicry") increases a(MESH:Autoantigens) - pmid:28901280 + pubmed:26445701 - a(CHEBI:"calcium cation") increases bp(MESH:"Cell Proliferation") + bp(MESH:"Molecular Mimicry") increases bp(GO:"T cell activation") - pmid:28901280 + pubmed:30988501 - a(CHEBI:"calcium cation") increases bp(MESH:"Cell Movement") + bp(MESH:"Molecular Mimicry") increases bp(GO:"activation of immune response") - pmid:28901280 + pubmed:30988501 - a(CHEBI:"calcium cation") decreases bp(MESH:Apoptosis) + bp(MESH:"Molecular Mimicry") increases path(MESH:"Autoimmune Diseases") - pmid:21722302 + pubmed:26445701 - a(CHEBI:"calcium cation", loc(GO:cytoplasm)) increases act(p(HGNC:CAMK2B)) + a(MESH:"Th17 Cells") association a(MESH:"Th1 Cells") - pmid:28901280 + pubmed:26445701 - p(HBP:"LY6 family") regulates p(MESH:"Receptors, Nicotinic") + a(MESH:"Th17 Cells") increases tloc(p(HGNC:IL17A), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - + + + pubmed:30988501 + + a(MESH:"Th17 Cells", loc(MESH:"Central Nervous System")) increases bp(MESH:"Immunity, Cellular") + - + + + pubmed:30988501 + + a(MESH:"Th17 Cells") increases path(HP:Autism) + - pmid:28901280 + pubmed:30967783 - g(DNSNP:rs1051730) association path(MESH:"Lung Neoplasms") + p(HGNC:IL4) increases act(a(NCIT:C123783)) - pmid:28901280 + pubmed:30967783 - g(DNSNP:rs1051730) association path(MESH:"Tobacco Use Disorder") + p(HGNC:IL4) decreases bp(GO:"inflammatory response") - pmid:28901280 + pubmed:30967783 - bp(GO:"JAK-STAT cascade") increases a(CHEBI:"calcium cation", loc(GO:intracellular)) + p(HGNC:IL4) decreases bp(GO:"inflammatory response") - pmid:28901280 + pubmed:30967783 - a(MESH:Epithelium) regulates a(MESH:Acetylcholine) + p(HGNC:IL4) increases bp(GO:"oligodendrocyte development") - pmid:28901280 + pubmed:30967783 - act(a(MESH:Epithelium)) association p(MGI:Chrna7) + p(HGNC:IL4) increases bp(MESH:Remyelination) - pmid:28901280 + pubmed:26979166 - a(MESH:Choline) increases act(p(HGNC:CHRNA9)) + p(HGNC:IL4) increases bp(GO:"mast cell activation") - pmid:28901280 + pubmed:31413141 - a(MESH:Phosphorylcholine) causesNoChange complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) + p(HGNC:IL4) increases bp(GO:"macrophage activation") - pmid:28901280 + pubmed:31413141 - a(MESH:Phosphorylcholine) causesNoChange p(HGNC:CHRNA9) + p(HGNC:IL4) increases bp(GO:"macrophage activation") - pmid:28901280 + pubmed:26979166 - a(MESH:"Ganglia, Spinal") increases complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) + p(HGNC:IL5) increases bp(GO:"mast cell activation") - pmid:28901280 + pubmed:30935091 - a(MESH:"Ganglia, Spinal") increases p(HGNC:CHRNA9) + path(DOID:"axonal neuropathy") decreases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) - pmid:28901280 + pubmed:26445701 - path(MESH:"Breast Neoplasms") increases p(HGNC:CHRNA9) + bp(GO:"complement activation") increases path(HP:"CNS demyelination") - pmid:28901280 + pubmed:26445701 - path(MESH:"Breast Neoplasms") increases p(HGNC:CHRNA5) + bp(GO:"complement activation") increases path(MESH:"Diffuse Axonal Injury") - pmid:28901280 + pubmed:26445701 - path(MESH:"Breast Neoplasms") increases p(HGNC:CHRNA10) + bp(GO:"complement activation") increases bp(GO:"positive regulation of oligodendrocyte apoptotic process") - pmid:30106381 + pubmed:30967783 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases a(GO:"dendritic spine") + bp(GO:"complement activation") increases bp(NCIT:C53611) - pmid:30106381 + pubmed:" 26517285" - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases a(GO:"dendritic spine") + bp(GO:"complement activation") association g(DBSNP:rs3824968) - pmid:30106381 + pubmed:26445701 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases a(GO:"dendritic spine") + a(HP:"Senile plaques") increases path(MESH:Inflammation) - pmid:30106381 + pubmed:26445701 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases a(GO:"dendritic spine") + a(HP:"Senile plaques") increases path(HP:"Axonal loss") - pmid:30106381 + pubmed:26445701 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases a(GO:"dendritic spine") + a(HP:"Focal white matter lesions") increases path(MESH:Inflammation) - pmid:30106381 + pubmed:26445701 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:DLG4) + a(HP:"Focal white matter lesions") decreases bp(GO:cognition) - pmid:30106381 + pubmed:26445701 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:DLG4) + bp(GO:"sensory perception") association path(DOID:"multiple sclerosis") - pmid:30106381 + pubmed:30012004 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases a(GO:"excitatory synapse") + bp(GO:"sensory perception") negativeCorrelation path(MESH:"Huntington Disease") - pmid:30106381 + pubmed:26445701 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases a(GO:"excitatory synapse") + bp(GO:"motor behavior") association path(DOID:"multiple sclerosis") - pmid:30106381 + pubmed:30515821 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) regulates complex(p(HGNC:ADNP), p(HGNC:DLG4)) + bp(GO:"motor behavior") positiveCorrelation p(HGNC:DNM1) - pmid:30106381 + pubmed:30012004 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) regulates complex(p(HGNC:ADNP), p(HGNC:AKT1)) + bp(GO:"motor behavior") negativeCorrelation path(MESH:"Huntington Disease") - pmid:30106381 + pubmed:30985105 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases p(HGNC:FPR3) + bp(GO:"motor behavior") negativeCorrelation deg(a(CONSO:"Dopaminergic cell groups")) - pmid:30106381 + pubmed:30985105 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:TUBB1) + bp(GO:"motor behavior") decreases path(MESH:Hypokinesia) - pmid:30106381 + pubmed:30985105 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) regulates act(p(HGNC:LIPA)) + bp(GO:"motor behavior") decreases path(MESH:"Muscle Rigidity") - pmid:30106381 + pubmed:30985105 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases p(HGNC:HIST1H3B) + bp(GO:"motor behavior") decreases path(HP:"Postural instability") - pmid:30106381 + pubmed:26445701 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) regulates p(HGNC:HIST1H3B) + bp(GO:"visual behavior") association path(DOID:"multiple sclerosis") - pmid:30106381 + pubmed:30988501 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:ABCF3) + path(HP:Fatigue) increases bp(MESH:Survival) - pmid:30106381 + pubmed:26445701 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:BMP4) + a(DRUGBANK:Methylprednisolone) decreases path(DOID:"relapsing-remitting multiple sclerosis") - pmid:30106381 + pubmed:26445701 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:CDH17) + a(DRUGBANK:Methylprednisolone) decreases path(MESH:Inflammation) - pmid:30106381 + pubmed:26445701 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:KDM5D) + a(DRUGBANK:Methylprednisolone) isA a(CHEBI:immunomodulator) - pmid:30106381 + pubmed:26445701 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:KLF1) + a(MESH:"Adrenocorticotropic Hormone") decreases path(DOID:"relapsing-remitting multiple sclerosis") - pmid:30106381 + pubmed:26445701 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:PER1) + a(MESH:"Adrenocorticotropic Hormone") decreases path(MESH:Inflammation) - pmid:30106381 + pubmed:26445701 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:AKT1) + a(MESH:"Adrenocorticotropic Hormone") isA a(CHEBI:immunomodulator) - pmid:30106381 + pubmed:26445701 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:AIF1) + p(HGNCGENEFAMILY:Interferons) isA a(CHEBI:"antiviral agent") - pmid:30106381 + pubmed:26445701 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases path(MESH:"Psychomotor Performance") + p(HGNCGENEFAMILY:Interferons) isA a(CHEBI:"antibacterial agent") - pmid:30106381 + pubmed:26445701 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases path(MESH:"Psychomotor Performance") + p(HGNCGENEFAMILY:Interferons) decreases path(DOID:"multiple sclerosis") - pmid:30106381 + pubmed:26445701 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Vestibular Diseases") + a(MESH:"Blood-Brain Barrier") association p(HGNC:IFNB1) - pmid:30106381 + pubmed:26195256 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) negativeCorrelation bp(MESH:"Body Height") + a(MESH:"Blood-Brain Barrier") decreases a(CHEBI:amyloid-beta, loc(GO:"extracellular region")) - pmid:30106381 + pubmed:30988501 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) negativeCorrelation path(MESH:"Weight Gain") + deg(a(MESH:"Blood-Brain Barrier")) decreases p(HGNC:CLDN5) - pmid:30106381 + pubmed:26445701 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases path(MESH:"Motor Activity") + bp(GO:"T-helper 2 cell cytokine production") decreases path(MESH:Inflammation) - pmid:30106381 + pubmed:26445701 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange path(MESH:"Motor Activity") + complex(a(DRUGBANK:Natalizumab), p(HGNC:ITGA4), p(HGNC:ITGB1)) decreases complex(p(HGNC:ITGA4), p(HGNC:ITGB1), p(HGNC:VCAM1)) - pmid:30106381 + pubmed:26445701 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases bp(MESH:"Hand Strength") + complex(a(DRUGBANK:Natalizumab), p(HGNC:ITGA4), p(HGNC:ITGB1)) decreases bp(MESH:"Transendothelial and Transepithelial Migration") - pmid:30106381 + pubmed:26445701 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange bp(MESH:"Hand Strength") + complex(p(HGNC:ITGA4), p(HGNC:ITGB1), p(HGNC:VCAM1)) increases bp(MESH:"Transendothelial and Transepithelial Migration") - pmid:30106381 + pubmed:26445701 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases path(MESH:"Recognition (Psychology)") + a(MESH:"JC Virus") increases path(DOID:"progressive multifocal leukoencephalopathy") - pmid:30106381 + pubmed:26445701 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Autistic Disorder") + a(CHEBI:mitoxantrone) isA a(CHEBI:"antineoplastic agent") - pmid:30106381 + pubmed:26445701 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases path(MESH:Smell) + a(CHEBI:mitoxantrone) decreases a(MESH:B-Lymphocytes) - pmid:30106381 + pubmed:26445701 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange path(MESH:Smell) + a(CHEBI:mitoxantrone) decreases a(MESH:T-Lymphocytes) - pmid:30106381 + pubmed:26445701 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases bp(GO:"social behavior") + a(CHEBI:mitoxantrone) decreases bp(GO:"macrophage proliferation") - pmid:30664622 + pubmed:26445701 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases bp(GO:"social behavior") + a(CHEBI:mitoxantrone) decreases path(DOID:"relapsing-remitting multiple sclerosis") - pmid:30664622 + pubmed:26445701 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases bp(GO:"social behavior") + a(CHEBI:mitoxantrone) decreases path(DOID:"secondary progressive multiple sclerosis") - pmid:30664622 + pubmed:26445701 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases bp(GO:memory) + a(CHEBI:mitoxantrone) increases path(MESH:Cardiotoxicity) - pmid:30664622 + pubmed:26445701 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Motor Skills Disorders") + a(CHEBI:mitoxantrone) increases path(DOID:leukemia) - pmid:30664622 + pubmed:26445701 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Brain Injuries") + a(CHEBI:fingolimod) decreases path(DOID:"relapsing-remitting multiple sclerosis") - pmid:30664622 + pubmed:26445701 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases a(MESH:"Nerve Fibers, Myelinated") + a(CHEBI:fingolimod) regulates p(HGNC:S1PR1) - pmid:30664622 + pubmed:26445701 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange p(HGNC:SLC17A7) + a(CHEBI:fingolimod) decreases path(DOID:"multiple sclerosis") + + - pmid:30664622 + pubmed:26445701 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases p(HGNC:SLC17A7) + a(CHEBI:fingolimod) increases path(HP:Bradycardia) - pmid:30664622 + pubmed:26445701 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases p(HGNC:SLC17A7) + a(CHEBI:fingolimod) increases path(DOID:"atrioventricular block") - pmid:30664622 + pubmed:26445701 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases r(HGNC:SLC17A7) + a(CHEBI:fingolimod) increases path(DOID:"herpes simplex") - pmid:30008470 + pubmed:26445701 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases r(HGNC:ADNP) + a(CHEBI:fingolimod) increases path(HP:"Macular edema") - pmid:30008470 + pubmed:26445701 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Alcohol Drinking") + a(CHEBI:fingolimod) increases bp(GO:"positive regulation of blood pressure") - pmid:30008470 + pubmed:26445701 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange path(MESH:"Alcohol Drinking") + a(CHEBI:fingolimod) increases path(DOID:"progressive multifocal leukoencephalopathy") - pmid:30008470 + pubmed:26445701 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Alcohol Drinking") + a(CHEBI:teriflunomide) decreases path(DOID:"relapsing-remitting multiple sclerosis") - pmid:30008470 + pubmed:26445701 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Alcohol Drinking") + a(CHEBI:teriflunomide) decreases p(HGNC:DHODH) - pmid:30008470 + pubmed:26445701 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange tloc(a(CHEBI:saccharin), fromLoc(GO:"extracellular space"), toLoc(GO:intracellular)) + a(CHEBI:teriflunomide) decreases act(a(MESH:T-Lymphocytes)) - pmid:30008470 + pubmed:26445701 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange tloc(a(CHEBI:quinine), fromLoc(GO:"extracellular space"), toLoc(GO:intracellular)) + a(CHEBI:teriflunomide) decreases act(a(MESH:B-Lymphocytes)) - pmid:30008470 + pubmed:26445701 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:TFAP2B) + a(CHEBI:teriflunomide) decreases path(MESH:Inflammation) - pmid:30008470 + pubmed:26445701 - p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases p(HGNC:TFAP2B) + a(CHEBI:teriflunomide) increases path(MESH:Alopecia) - pmid:30106381 + pubmed:26445701 - p(HGNC:DLG4) regulates act(p(HGNC:ADNP)) + a(CHEBI:teriflunomide) increases path(HP:Headache) - pmid:30664622 + pubmed:26445701 - p(HGNC:DLG4) association act(p(HGNC:ADNP)) + a(CHEBI:teriflunomide) increases path(DOID:diarrhea) - pmid:30106381 + pubmed:26445701 - p(HGNC:DLG4) regulates act(a(PUBCHEM:9832404)) + a(CHEBI:teriflunomide) increases p(MESH:Enzymes) - pmid:30664622 + pubmed:26445701 - p(HGNC:DLG4) association act(a(PUBCHEM:9832404)) + a(CHEBI:teriflunomide) decreases a(MESH:Lymphocytes) - pmid:30106381 + pubmed:26445701 - p(HGNC:DLG4) association bp(GO:"regulation of synaptic plasticity") + a(CHEBI:teriflunomide) decreases a(MESH:Neutrophils) - pmid:24760868 + pubmed:26445701 - p(HGNC:DLG4) positiveCorrelation bp(GO:"long-term synaptic potentiation") + a(CHEBI:teriflunomide) increases bp(GO:"positive regulation of blood pressure") - pmid:26751493 + pubmed:26445701 - p(HGNC:DLG4) association p(HBP:"projection domain") + a(CHEBI:teriflunomide) increases path(DOID:tuberculosis) + + + pubmed:26445701 + + complex(a(CHEBI:fingolimod), p(HGNC:S1PR1), loc(MESH:T-Lymphocytes)) decreases tloc(a(MESH:T-Lymphocytes), fromLoc(MESH:"Lymph Nodes"), toLoc(MESH:"Central Nervous System")) + + - pmid:30106381 + pubmed:26445701 - composite(a(PUBCHEM:9832404), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) decreases a(GO:"dendritic spine") + a(CHEBI:leflunomide) decreases path(HP:"Rheumatoid arthritis") - pmid:30664622 + pubmed:26445701 - composite(a(PUBCHEM:9832404), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) increases path(MESH:Smell) + a(CHEBI:leflunomide) increases a(CHEBI:teriflunomide) - pmid:30664622 + pubmed:26445701 - composite(a(PUBCHEM:9832404), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) decreases path(MESH:Smell) + p(HGNC:DHODH) decreases a(MESH:Pyrimidines) - pmid:30008470 + pubmed:26445701 - composite(a(PUBCHEM:9832404), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) decreases path(MESH:"Alcohol Drinking") + composite(a(CHEBI:"dimethyl fumarate"), a(CHEBI:food)) decreases path(HP:"Abdominal pain") + + - pmid:30106381 + pubmed:26445701 - bp(GO:"nervous system development") association p(HGNC:ADNP) + a(MESH:Aspirin) decreases path(HP:Flushing) - pmid:30106381 + pubmed:4255369 - bp(GO:"nervous system development") association a(PUBCHEM:9832404) + path(MESH:"Motor Disorders") increases bp(GO:"cell death") - pmid:30106381 + pubmed:29687724 - bp(GO:"AMPA glutamate receptor clustering") association p(HGNC:ADNP) + path(MESH:"Motor Disorders") association path(MESH:"Huntington Disease") - pmid:30106381 + pubmed:27889190 - bp(GO:"AMPA glutamate receptor clustering") association a(PUBCHEM:9832404) + bp(MESH:"Axonal Transport") association path(DOID:"multiple sclerosis") - pmid:30106381 + pubmed:27889190 - bp(GO:"social behavior") association p(HGNC:ADNP) + path(DOID:"progressive relapsing multiple sclerosis") association a(MESH:"Gray Matter") - pmid:30106381 + pubmed:27889190 - bp(GO:"social behavior") association a(PUBCHEM:9832404) + path(DOID:"progressive relapsing multiple sclerosis") increases bp(GO:"microglial cell activation") - pmid:30106381 + pubmed:27889190 - bp(GO:"vocalization behavior") association p(HGNC:ADNP) + path(DOID:"progressive relapsing multiple sclerosis") increases path(HP:"CNS demyelination") - pmid:30106381 + pubmed:27889190 - bp(GO:"vocalization behavior") association a(PUBCHEM:9832404) + path(DOID:"progressive relapsing multiple sclerosis") association a(MESH:Neurites) - + + + pubmed:27889190 + + path(DOID:"progressive relapsing multiple sclerosis") increases bp(MESH:"Cell Death") + - + + + pubmed:27889190 + + path(DOID:"progressive relapsing multiple sclerosis") decreases a(MESH:"Presynaptic Terminals") + + + + pubmed:27889190 + + path(DOID:"progressive relapsing multiple sclerosis") increases path(NCIT:C117277) + + - pmid:21882945 + pubmed:27889190 - p(HGNC:AKT1) association complex(p(FPLX:HSP90), p(HGNC:STUB1)) + path(DOID:"progressive relapsing multiple sclerosis") increases path(MESH:Atrophy) - pmid:21882945 + pubmed:27889190 - p(HGNC:AKT1) negativeCorrelation deg(p(HGNC:MAPT)) + path(DOID:"progressive relapsing multiple sclerosis") negativeCorrelation bp(MESH:"Energy Metabolism") - pmid:21367866 + pubmed:27889190 - act(p(HGNC:AKT1), ma(kin)) positiveCorrelation complex(p(FPLX:HSP90), p(HGNC:CDC37)) + a(MESH:"Gray Matter") association path(DOID:"progressive relapsing multiple sclerosis") - pmid:30106381 + pubmed:30012004 - p(HGNC:AKT1, var("?")) increases path(MESH:"Proteus Syndrome") + a(MESH:"Gray Matter") negativeCorrelation path(MESH:"Huntington Disease") - pmid:30106381 + pubmed:30988501 - g(HGNC:"IQCJ-SCHIP1") increases bp(GO:"calcium-mediated signaling") + deg(a(MESH:"Gray Matter")) decreases bp(GO:cognition) - pmid:30106381 + pubmed:30988501 - g(HGNC:"IQCJ-SCHIP1") increases bp(GO:"action potential") + deg(a(MESH:"Gray Matter")) increases deg(a(MESH:"Cerebral Cortex")) - pmid:30106381 + pubmed:27889190 - g(HGNC:"IQCJ-SCHIP1") increases bp(MESH:"Neuronal Outgrowth") + a(MESH:Neurites) association path(DOID:"progressive relapsing multiple sclerosis") - pmid:30106381 + pubmed:22908190 - g(HGNC:"IQCJ-SCHIP1") association p(HGNC:ADNP) + act(a(MESH:Neurites)) negativeCorrelation p(HGNC:APP, var("?")) - pmid:30106381 + pubmed:28877763 - g(HGNC:"IQCJ-SCHIP1") association a(PUBCHEM:9832404) + a(MESH:Neurites) positiveCorrelation act(p(MGI:Syk)) - pmid:30106381 + pubmed:21722302 - p(HGNC:LIPA) increases bp(GO:"lipid metabolic process") + bp(MESH:"Cell Death") increases tloc(p(HGNC:SNCA), fromLoc(GO:intracellular), toLoc(GO:"extracellular space")) - pmid:22142809 + pubmed:21482353 - p(HGNC:LIPA) negativeCorrelation p(HBP:RAC1b) + a(MESH:"Presynaptic Terminals") increases tloc(a(CHEBI:acetylcholine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) - pmid:30106381 + pubmed:27671637 - p(HGNC:NLGN2) association a(PUBCHEM:9832404) + a(MESH:"Presynaptic Terminals") causesNoChange p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) - pmid:30106381 + pubmed:27889190 - p(HGNC:NLGN2) association p(HGNC:ADNP) + path(NCIT:C117277) association bp(MESH:"Neural Conduction") - pmid:30106381 + pubmed:27889190 - p(HGNC:PAX6) association a(PUBCHEM:9832404) + path(NCIT:C117277) increases bp(MESH:"Energy Metabolism") - pmid:30106381 + pubmed:27889190 - p(HGNC:WFS1) association path(HBP:Neurodegeneration) + path(NCIT:C117277) increases a(MESH:Sodium, loc(GO:"axon cytoplasm")) - pmid:30106381 + pubmed:27889190 - p(HGNC:WFS1) regulates bp(GO:"cellular calcium ion homeostasis") + bp(MESH:"Neural Conduction") association path(NCIT:C117277) - pmid:30106381 + pubmed:27889190 - p(HGNC:WFS1) association p(HGNC:ADNP) + bp(MESH:"Energy Metabolism") negativeCorrelation path(DOID:"progressive relapsing multiple sclerosis") - pmid:30106381 + pubmed:30515821 - path(MESH:Intelligence) association p(HGNC:ADNP) + bp(MESH:"Energy Metabolism") negativeCorrelation act(p(HGNC:DNM1L)) - pmid:26010758 + pubmed:30515821 - p(HGNC:AIF1) positiveCorrelation bp(GO:"microglial cell activation") + bp(MESH:"Energy Metabolism") negativeCorrelation path(DOID:"motor neuron disease") - pmid:30106381 + pubmed:21718217 - bp(GO:translation) association p(HGNC:MTOR) + bp(MESH:"Energy Metabolism") association p(FPLX:PPAR) - pmid:27181519 + pubmed:21718217 - bp(GO:translation) negativeCorrelation complex(GO:"cytoplasmic stress granule") + bp(MESH:"Energy Metabolism") positiveCorrelation p(FPLX:PPAR) - pmid:30106381 + pubmed:21718217 - bp(MESH:"Body Height") negativeCorrelation p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) + bp(MESH:"Energy Metabolism") association p(HGNC:PPARG) - pmid:30106381 + pubmed:21718217 - path(MESH:"Weight Gain") negativeCorrelation p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) + bp(MESH:"Energy Metabolism") association p(HGNC:PPARGC1A) - pmid:28391535 + pubmed:30012004 - path(MESH:"Motor Activity") negativeCorrelation a(CHEBI:nicotine) + bp(MESH:"Energy Metabolism") negativeCorrelation path(MESH:"Huntington Disease") - pmid:30664622 + pubmed:20556492 - path(MESH:Smell) regulates bp(GO:"social behavior") + bp(MESH:"Energy Metabolism") negativeCorrelation path(DOID:"Huntington's disease") - pmid:30664622 + pubmed:26968346 - a(CHEBI:chlorobutanol) increases tloc(a(PUBCHEM:9832404), fromLoc(GO:"extracellular region"), toLoc(MESH:Brain)) + bp(MESH:"Energy Metabolism") decreases tloc(a(CHEBI:"calcium(2+)"), fromLoc(GO:lysosome), toLoc(GO:cytoplasm)) - pmid:30664622 + pubmed:25784053 - a(CHEBI:chlorobutanol) increases tloc(a(PUBCHEM:9832404), fromLoc(GO:"extracellular region"), toLoc(MESH:"Cell Body")) + bp(MESH:"Energy Metabolism") association p(HGNC:HSPD1) - pmid:30664622 + pubmed:27889190 - a(CHEBI:chlorobutanol) increases tloc(a(PUBCHEM:9832404), fromLoc(GO:"extracellular region"), toLoc(MESH:Brain)) + a(MESH:Sodium, loc(GO:"axon cytoplasm")) increases act(p(MESH:"Sodium-Calcium Exchanger")) + + - pmid:30664622 + pubmed:27889190 - a(CHEBI:chlorobutanol) causesNoChange a(MESH:"Blood-Brain Barrier") + composite(a(MESH:Sodium), p(MESH:"Sodium-Calcium Exchanger")) increases a(CHEBI:"calcium cation", loc(GO:"axon cytoplasm")) - pmid:30664622 + pubmed:27889190 - a(CHEBI:chlorobutanol) increases bp(GO:"social behavior") + a(CHEBI:"calcium cation", loc(GO:"axon cytoplasm")) increases act(p(HGNCGENEFAMILY:Calpains)) - pmid:30664622 + pubmed:27889190 - a(CHEBI:chlorobutanol) causesNoChange path(MESH:Smell) + a(CHEBI:"calcium cation", loc(GO:"axon cytoplasm")) decreases a(GO:cytoskeleton) - pmid:30664622 + pubmed:28901280 - a(CHEBI:chlorobutanol) decreases path(MESH:Smell) + a(CHEBI:"calcium cation") increases bp(MESH:"Cell Proliferation") - pmid:30664622 + pubmed:28901280 - a(CHEBI:"Evans blue") causesNoChange tloc(a(PUBCHEM:9832404), fromLoc(GO:"extracellular region"), toLoc(MESH:Brain)) + a(CHEBI:"calcium cation") increases bp(MESH:"Cell Movement") - pmid:30664622 + pubmed:28901280 - a(CHEBI:"Evans blue") increases tloc(a(PUBCHEM:9832404), fromLoc(GO:"extracellular region"), toLoc(GO:"cell periphery")) + a(CHEBI:"calcium cation") increases bp(GO:angiogenesis) - pmid:30664622 + pubmed:28901280 - a(CHEBI:"Evans blue") causesNoChange tloc(a(PUBCHEM:9832404), fromLoc(GO:"extracellular region"), toLoc(MESH:Brain)) + a(CHEBI:"calcium cation") decreases bp(MESH:Apoptosis) - pmid:26195256 + pubmed:21722302 - a(MESH:"Blood-Brain Barrier") decreases a(CHEBI:"amyloid-beta", loc(GO:"extracellular region")) + a(CHEBI:"calcium cation", loc(GO:cytoplasm)) increases act(p(HGNC:CAMK2B)) + + + pubmed:30061532 + + act(a(GO:cytoskeleton)) association p(HGNC:DTNBP1) + + - pmid:30664622 + pubmed:27889190 - composite(a(CHEBI:chlorobutanol), a(PUBCHEM:9832404)) increases bp(GO:memory) + bp(GO:"mitochondrial transport") negativeCorrelation path(CONSO:"mitochondrial dysfunction") - pmid:30664622 + pubmed:27889190 - composite(a(CHEBI:chlorobutanol), a(PUBCHEM:9832404)) increases bp(GO:"social behavior") + path(CONSO:"mitochondrial dysfunction") negativeCorrelation bp(GO:"mitochondrial transport") - pmid:30664622 + pubmed:27889190 - composite(a(CHEBI:chlorobutanol), a(PUBCHEM:9832404)) increases a(MESH:"Nerve Fibers, Myelinated") + path(CONSO:"mitochondrial dysfunction") increases path(MESH:"Oxidative Stress") - + + + pubmed:27889190 + + path(CONSO:"mitochondrial dysfunction") increases path(MESH:"DNA Damage") + - pmid:30664622 + pubmed:30967783 - composite(a(PUBCHEM:59557), a(PUBCHEM:9832404)) decreases bp(GO:"social behavior") + path(CONSO:"mitochondrial dysfunction") association path(DOID:"multiple sclerosis") + + + pubmed:17017864 + + path(CONSO:"mitochondrial dysfunction") increases bp(GO:"cell death") + + + + + pubmed:17017864 + + path(CONSO:"mitochondrial dysfunction") increases bp(GO:"apoptotic process") + + - pmid:30664622 + pubmed:23516100 - composite(a(CHEBI:chlorobutanol), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) decreases path(MESH:Smell) + path(CONSO:"mitochondrial dysfunction") positiveCorrelation p(HGNC:APP, frag("1_?")) - pmid:30664622 + pubmed:23516100 - composite(a(CHEBI:chlorobutanol), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) increases path(MESH:Smell) + path(CONSO:"mitochondrial dysfunction") increases act(p(HGNCGENEFAMILY:Caspases)) - pmid:30664622 + pubmed:30362565 - p(HGNC:SLC17A7) regulates bp(GO:"glutamate homeostasis") + path(CONSO:"mitochondrial dysfunction") increases a(CHEBI:"reactive oxygen species") - pmid:30664622 + pubmed:29758300 - p(HGNC:SLC17A7) increases bp(GO:"L-glutamate import") + path(CONSO:"mitochondrial dysfunction") increases a(CHEBI:"reactive oxygen species") + + + pubmed:30012004 + + path(CONSO:"mitochondrial dysfunction") positiveCorrelation path(MESH:"Huntington Disease") + + - pmid:30012004 + pubmed:21722302 - bp(GO:"motor behavior") negativeCorrelation path(MESH:"Huntington Disease") + path(CONSO:"mitochondrial dysfunction") increases bp(GO:"motor neuron apoptotic process") - pmid:30985105 + pubmed:27299292 - bp(GO:"motor behavior") negativeCorrelation deg(a(HBP:"Dopaminergic cell groups")) + path(CONSO:"mitochondrial dysfunction") positiveCorrelation path(DOID:"spinal muscular atrophy") - pmid:30985105 + pubmed:29758300 - bp(GO:"motor behavior") decreases path(MESH:Hypokinesia) + path(CONSO:"mitochondrial dysfunction") increases path(MESH:"Alzheimer Disease") - pmid:30985105 + pubmed:29758300 - bp(GO:"motor behavior") decreases path(MESH:"Muscle Rigidity") + path(CONSO:"mitochondrial dysfunction") increases path(MESH:"Alzheimer Disease") - pmid:30985105 + pubmed:29758300 - bp(GO:"motor behavior") decreases path(HP:"Postural instability") + path(CONSO:"mitochondrial dysfunction") decreases a(CHEBI:ATP) - pmid:29724491 + pubmed:29758300 - p(HGNC:ADNP, frag("1_719")) decreases bp(GO:"walking behavior") + path(CONSO:"mitochondrial dysfunction") increases a(CHEBI:amyloid-beta) - pmid:30008470 + pubmed:29758300 - path(MESH:"Alcohol Drinking") increases r(HGNC:ADNP) + path(CONSO:"mitochondrial dysfunction") increases p(HGNC:MAPT) - pmid:30008470 + pubmed:29758300 - path(MESH:"Alcohol Drinking") increases p(HGNC:ADNP) + path(CONSO:"mitochondrial dysfunction") increases bp(GO:mitophagy) - pmid:30008470 + pubmed:28173111 - path(MESH:"Alcohol Drinking") causesNoChange p(HGNC:ADNP) + path(CONSO:"mitochondrial dysfunction") positiveCorrelation r(MGI:Dnm1l) - pmid:30008470 + pubmed:27181519 - path(MESH:"Alcohol Drinking") causesNoChange p(HGNC:ADNP) + path(CONSO:"mitochondrial dysfunction") increases complex(GO:"cytoplasmic stress granule") - pmid:30008470 + pubmed:30988501 - path(MESH:"Alcohol Drinking") increases p(HGNC:ADNP) + path(CONSO:"mitochondrial dysfunction") increases deg(a(MESH:Neurons)) - pmid:30008470 + pubmed:27889190 - path(MESH:"Alcohol Drinking") decreases p(HGNC:ADNP) + path(MESH:"DNA Damage") decreases bp(MESH:"Energy Metabolism") - pmid:30008470 + pubmed:27889190 - path(MESH:"Alcohol Drinking") causesNoChange p(HGNC:ADNP) + path(MESH:"DNA Damage") increases a(MESH:"Reactive Oxygen Species") - pmid:30008470 + pubmed:30967783 - path(MESH:"Alcohol Drinking") negativeCorrelation g(HGNC:ADNP) + a(MESH:"Reactive Oxygen Species") increases path(MESH:"Mitochondrial Degradation") - pmid:30008470 + pubmed:26979166 - path(MESH:"Alcohol Drinking") decreases p(HGNC:TFAP2B) + a(MESH:"Reactive Oxygen Species") increases deg(a(MESH:"White Matter")) - pmid:30008470 + pubmed:26979166 - g(HGNC:ADNP) negativeCorrelation path(MESH:"Alcohol Drinking") + a(MESH:"Reactive Oxygen Species") increases deg(a(MESH:"Gray Matter")) - - - - - pmid:22807490 + pubmed:27889190 - path(MESH:"Hashimoto Disease") association path(MESH:Smoking) + a(CHEBI:biotin) increases bp(MESH:"Energy Metabolism") - pmid:22807490 + pubmed:27889190 - p(HGNC:TPO) negativeCorrelation path(MESH:Smoking) + a(CHEBI:biotin) increases act(a(MESH:Axons)) - pmid:22807490 + pubmed:27889190 - path(MESH:"Thyroiditis, Autoimmune") increases p(HGNC:IL1R2) + a(CHEBI:biotin) decreases path(CONSO:Neurodegeneration) - pmid:22807490 + pubmed:27889190 - a(CHEBI:lipopolysaccharide) increases bp(GO:"macrophage activation") + a(CHEBI:biotin) increases bp(MESH:Remyelination) - pmid:23178521 + pubmed:30061532 - a(CHEBI:lipopolysaccharide) increases p(HGNC:STAT3, pmod(Ph)) + path(CONSO:Neurodegeneration) association act(a(GO:synapse)) - pmid:23178521 + pubmed:19126755 - a(CHEBI:lipopolysaccharide) increases p(HGNC:STAT3, pmod(Ph)) + path(CONSO:Neurodegeneration) increases bp(GO:cognition) - pmid:23178521 + pubmed:19126755 - a(CHEBI:lipopolysaccharide) increases p(HGNC:STAT3, pmod(Ph)) + path(CONSO:Neurodegeneration) negativeCorrelation p(MGI:Chrnb2) - pmid:23178521 + pubmed:26813123 - a(CHEBI:lipopolysaccharide) increases p(HGNC:RELA, pmod(Ph)) + path(CONSO:Neurodegeneration) negativeCorrelation bp(GO:memory) - pmid:23178521 + pubmed:26813123 - a(CHEBI:lipopolysaccharide) increases p(HGNC:RELA, pmod(Ph)) + path(CONSO:Neurodegeneration) association bp(GO:"synaptic transmission, glutamatergic") - pmid:23178521 + pubmed:26813123 - a(CHEBI:lipopolysaccharide) increases p(HGNC:RELA, pmod(Ph)) + path(CONSO:Neurodegeneration) association bp(GO:"synaptic transmission, cholinergic") - pmid:23178521 + pubmed:31248781 - a(CHEBI:lipopolysaccharide) increases p(HGNC:RELA, pmod(Ph)) + path(CONSO:Neurodegeneration) association p(MESH:"Neurofibrillary Tangles") - pmid:23178521 + pubmed:18986241 - a(CHEBI:lipopolysaccharide) increases p(HGNC:IL1B) + path(CONSO:Neurodegeneration) association path(MESH:"Cognitive Dysfunction") - pmid:23178521 + pubmed:30106381 - a(CHEBI:lipopolysaccharide) increases p(MGI:Il1b) + path(CONSO:Neurodegeneration) association p(HGNC:WFS1) - pmid:23178521 + pubmed:21722302 - a(CHEBI:lipopolysaccharide) increases p(MGI:Il1b) + path(CONSO:Neurodegeneration) association path(MESH:"Alzheimer Disease") - pmid:23178521 + pubmed:21722302 - a(CHEBI:lipopolysaccharide) increases p(MGI:Il1b) + path(CONSO:Neurodegeneration) association path(MESH:"Parkinson Disease") - pmid:23178521 + pubmed:21722302 - a(CHEBI:lipopolysaccharide) increases p(MGI:Il6) + path(CONSO:Neurodegeneration) association path(MESH:"Amyotrophic Lateral Sclerosis") - pmid:23178521 + pubmed:21722302 - a(CHEBI:lipopolysaccharide) increases p(MGI:Il6) + path(CONSO:Neurodegeneration) association path(MESH:"Amyotrophic Lateral Sclerosis") - pmid:23178521 + pubmed:21722302 - a(CHEBI:lipopolysaccharide) increases p(MGI:Il6) + path(CONSO:Neurodegeneration) association path(MESH:"Prion Diseases") - pmid:23178521 + pubmed:21722302 - a(CHEBI:lipopolysaccharide) increases p(MGI:Tnf) + path(CONSO:Neurodegeneration) association a(CONSO:"amyloid-beta aggregates") - pmid:23178521 + pubmed:29758300 - a(CHEBI:lipopolysaccharide) increases p(MGI:Tnf) + path(CONSO:Neurodegeneration) negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:23178521 + pubmed:18930136 - a(CHEBI:lipopolysaccharide) increases p(MGI:Tnf) + path(CONSO:Neurodegeneration) negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:23178521 + pubmed:18930136 - a(CHEBI:lipopolysaccharide) increases p(MGI:Stat3, pmod(Ph)) + path(CONSO:Neurodegeneration) negativeCorrelation bp(GO:"cellular protein catabolic process") - pmid:25672970 + pubmed:17403556 - a(CHEBI:lipopolysaccharide) increases bp(GO:"neuroinflammatory response") + path(CONSO:Neurodegeneration) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:19323834 + pubmed:26631930 - a(CHEBI:lipopolysaccharide) decreases p(HGNC:SUMO1) + path(CONSO:Neurodegeneration) association tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) - pmid:21958873 + pubmed:26631930 - a(PUBCHEM:71311633) causesNoChange a(CHEBI:"amyloid-beta") + path(CONSO:Neurodegeneration) association act(p(HGNC:MAPT)) - pmid:21958873 + pubmed:17187063 - a(PUBCHEM:71311633) increases act(a(MESH:"Receptors, Nicotinic")) + path(CONSO:Neurodegeneration) positiveCorrelation complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) - pmid:21958873 + pubmed:19251756 - a(PUBCHEM:56972222) causesNoChange a(CHEBI:"amyloid-beta") + path(CONSO:Neurodegeneration) negativeCorrelation act(p(INTERPRO:"Triosephosphate isomerase")) - pmid:21958873 + pubmed:22952452 - a(PUBCHEM:56972222) increases act(a(MESH:"Receptors, Nicotinic")) + path(CONSO:Neurodegeneration) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) - pmid:21958873 + pubmed:27181519 - a(PUBCHEM:11957537) causesNoChange a(CHEBI:"amyloid-beta") + path(CONSO:Neurodegeneration) association p(HGNC:TBK1) - pmid:21958873 + pubmed:27889190 - a(PUBCHEM:11957537) decreases act(a(MESH:"Receptors, Nicotinic")) + a(DRUGBANK:Clemastine) increases bp(MESH:"Vision, Ocular") - pmid:23178521 + pubmed:27889190 - a(CHEBI:stattic) decreases p(HGNC:STAT3, pmod(Ph)) + a(DRUGBANK:Clemastine) increases bp(HP:"Optic neuropathy") - pmid:23178521 + pubmed:30967783 - a(CHEBI:stattic) decreases p(HGNC:STAT3, pmod(Ph)) + bp(GO:"neuroinflammatory response") increases path(DOID:"multiple sclerosis") - pmid:23178521 + pubmed:30967783 - a(CHEBI:stattic) decreases complex(p(HGNC:STAT3), p(HGNC:STAT3)) + bp(GO:"neuroinflammatory response") increases tloc(p(HGNC:TNF), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:23178521 + pubmed:30967783 - a(CHEBI:stattic) decreases p(HGNC:RELA, pmod(Ph)) + bp(GO:"neuroinflammatory response") increases tloc(p(HGNC:C1QA), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - - - - - - - pmid:23178521 + pubmed:30967783 - composite(a(CHEBI:Anatabine), a(MESH:Blood)) decreases p(HGNC:IL1B) + bp(GO:"neuroinflammatory response") decreases act(a(MESH:Astrocytes)) - - - + + + pubmed:30967783 + + bp(GO:"neuroinflammatory response") negativeCorrelation act(a(MESH:Neurons)) + - pmid:23178521 + pubmed:30967783 - composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide), a(MESH:Blood)) decreases p(HGNC:IL1B) + bp(GO:"neuroinflammatory response") negativeCorrelation act(a(MESH:Oligodendroglia)) - pmid:23383175 + pubmed:30988501 - p(MGI:Il1b) positiveCorrelation path(MESH:Encephalomyelitis) + bp(GO:"neuroinflammatory response") increases path(MESH:"Mental Disorders") - pmid:23383175 + pubmed:30967783 - p(MGI:Il6) positiveCorrelation path(MESH:Encephalomyelitis) + complex(p(HGNC:CX3CL1), p(HGNC:CX3CR1)) increases bp(MESH:"Neuronal Plasticity") - pmid:23383175 + pubmed:30967783 - p(MGI:Tnf) positiveCorrelation path(MESH:Encephalomyelitis) + complex(p(HGNC:CX3CL1), p(HGNC:CX3CR1)) increases bp(GO:"generation of neurons") @@ -89594,2120 +90347,2169 @@

Statements

- pmid:23178521 + pubmed:30967783 - composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Il1b) + p(HGNC:CX3CR1) increases bp(MESH:"Cell Survival") + + - pmid:23178521 + pubmed:21482353 - composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Il1b) + bp(GO:"generation of neurons") association act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) - pmid:23178521 + pubmed:30935091 - composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Tnf) + bp(MESH:"Cell Survival") increases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) - pmid:23178521 + pubmed:22236693 - composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Tnf) + bp(MESH:"Cell Survival") positiveCorrelation p(HGNC:NGFR) - pmid:23178521 + pubmed:31248781 - composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Tnf) + bp(MESH:"Cell Survival") positiveCorrelation bp(MESH:Neuroprotection) - pmid:23178521 + pubmed:31248781 - composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Il6) + bp(MESH:"Cell Survival") association bp(GO:"neurotrophin signaling pathway") - pmid:23178521 + pubmed:31248781 - composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Il6) + bp(MESH:"Cell Survival") association p(HGNC:CREBBP) - pmid:23383175 + pubmed:28901280 - p(MGI:Stat3, pmod(Ph)) positiveCorrelation path(MESH:Encephalomyelitis) + bp(MESH:"Cell Survival") association a(MESH:Acetylcholine) - pmid:23383175 + pubmed:30126037 - p(MGI:Stat3, pmod(Ph)) positiveCorrelation path(MESH:Encephalomyelitis) + bp(MESH:"Cell Survival") association bp(GO:"cellular senescence") - pmid:23383175 + pubmed:29540553 - p(MGI:Stat3, pmod(Ph)) positiveCorrelation path(MESH:Encephalomyelitis) + bp(GO:"learning or memory") positiveCorrelation p(HGNC:SIRT1) - pmid:23383175 + pubmed:27190210 - p(MGI:Stat3, pmod(Ph)) association path(MESH:"Neurologic Manifestations") + bp(GO:"learning or memory") association p(HGNC:CHRNA7) - pmid:23383175 + pubmed:29428175 - p(MGI:Stat3, pmod(Ph)) positiveCorrelation p(MGI:Rela, pmod(Ph)) + bp(GO:"learning or memory") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - - - pmid:23383175 + pubmed:30697142 - p(MGI:Stat3) regulates bp(GO:"cytokine production") + bp(GO:"learning or memory") positiveCorrelation a(CHEBI:"(-)-cotinine") - pmid:23383175 + pubmed:30697142 - path(MESH:Encephalomyelitis) negativeCorrelation a(CHEBI:Anatabine) + bp(GO:"learning or memory") association bp(MESH:"Neuronal Plasticity") - pmid:23383175 + pubmed:30697142 - path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Il1b) + bp(GO:"learning or memory") negativeCorrelation act(p(HGNC:GSK3B)) - pmid:23383175 + pubmed:30740335 - path(MESH:Encephalomyelitis) increases p(MGI:Il1b) + bp(GO:"learning or memory") association p(HGNC:XBP1) - pmid:23383175 + pubmed:30967783 - path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Ifng) + p(HGNC:NTRK2) regulates bp(MESH:"Neuronal Plasticity") + + - pmid:23383175 + pubmed:27013968 - path(MESH:Encephalomyelitis) increases p(MGI:Ifng) + act(p(HGNC:NTRK2), ma(GO:"neurotrophin TRKB receptor binding")) negativeCorrelation p(HGNC:HTT, pmod(HBP:"CAG repeats")) + + - pmid:23383175 + pubmed:27013968 - path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Tnf) + act(p(HGNC:NTRK2)) increases bp(GO:"ERK1 and ERK2 cascade") - pmid:23383175 + pubmed:27181519 - path(MESH:Encephalomyelitis) increases p(MGI:Tnf) + act(p(HGNC:NTRK2)) positiveCorrelation g(HGNC:C9orf72) - pmid:23383175 + pubmed:30967783 - path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Il6) + bp(GO:"cellular response to stress") increases bp(GO:"microglial cell activation") - pmid:23383175 + pubmed:30967783 - path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Il17a) + bp(GO:"cellular response to stress") increases composite(a(MESH:Microglia), a(MESH:Neurons)) - pmid:23383175 + pubmed:30740335 - path(MESH:Encephalomyelitis) increases p(MGI:Stat3, pmod(Ph)) + bp(GO:"cellular response to stress") decreases bp(GO:"protein transport") - pmid:23383175 + pubmed:30740335 - path(MESH:Encephalomyelitis) increases p(MGI:Stat3, pmod(Ph)) + bp(GO:"cellular response to stress") increases p(HGNC:ATF6, loc(GO:nucleus)) - pmid:23383175 + pubmed:30740335 - path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Stat3, pmod(Ph)) + bp(GO:"cellular response to stress") association p(HGNC:SIGMAR1) - pmid:23383175 + pubmed:27209302 - path(MESH:Encephalomyelitis) increases p(MGI:Stat3, pmod(Ph)) + bp(GO:"cellular response to stress") increases act(p(HGNC:TFEB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) - pmid:23383175 + pubmed:27299292 - path(MESH:Encephalomyelitis) increases p(MGI:Stat3, pmod(Ph)) + bp(GO:"cellular response to stress") increases p(HGNC:TFEB) - pmid:23383175 + pubmed:27299292 - path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Stat3, pmod(Ph)) + bp(GO:"cellular response to stress") increases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) - pmid:23383175 + pubmed:27299292 - path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Stat3, pmod(Ph)) + bp(GO:"cellular response to stress") increases act(p(HGNC:TFEB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) - pmid:23383175 + pubmed:29758300 - path(MESH:Encephalomyelitis) increases p(MGI:Rela, pmod(Ph)) + bp(GO:"cellular response to stress") increases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) - pmid:23383175 + pubmed:29758300 - path(MESH:Encephalomyelitis) increases bp(HBP:Astrogliosis) + bp(GO:"cellular response to stress") increases complex(p(HGNC:TFEB), p(INTERPRO:"cAMP response element binding (CREB) protein")) - pmid:23383175 + pubmed:18930136 - path(MESH:Encephalomyelitis) increases bp(HBP:Astrogliosis) + bp(GO:"cellular response to stress") increases p(HGNC:SQSTM1) - pmid:23383175 + pubmed:18930136 - path(MESH:Encephalomyelitis) increases bp(HBP:Microgliosis) + bp(GO:"cellular response to stress") increases r(HGNC:SQSTM1) - pmid:23383175 + pubmed:21882945 - path(MESH:Encephalomyelitis) increases tloc(a(MESH:Leukocytes), fromLoc(GO:"extracellular region"), toLoc(MESH:"Spinal Cord")) + bp(GO:"cellular response to stress") increases a(MESH:"Heat-Shock Proteins") - pmid:23383175 + pubmed:21882945 - path(MESH:Encephalomyelitis) increases a(MESH:Microglia) + bp(GO:"cellular response to stress") increases a(CONSO:"Hsp27 oligomers") - pmid:23383175 + pubmed:30967783 - path(MESH:Encephalomyelitis) decreases a(GO:"myelin sheath") + path(MESH:Light) decreases bp(GO:"microglial cell activation") - pmid:23383175 + pubmed:30967783 - p(MGI:Ifng) positiveCorrelation path(MESH:Encephalomyelitis) + path(MESH:Light) decreases composite(a(MESH:Microglia), a(MESH:Neurons)) - pmid:23383175 + pubmed:22372633 - p(MGI:Il17a) positiveCorrelation path(MESH:Encephalomyelitis) + p(MESH:Proteins, pmod(CONSO:misfolded)) increases p(CONSO:"protein aggregates") - pmid:23383175 + pubmed:27181519 - p(MGI:Rela, pmod(Ph)) positiveCorrelation p(MGI:Stat3, pmod(Ph)) + p(MESH:Proteins, pmod(CONSO:misfolded)) increases p(CONSO:"protein aggregates") - - - pmid:23383175 + pubmed:21722302 - p(MGI:Rela) regulates bp(GO:"cytokine production") + p(MESH:Proteins, pmod(CONSO:misfolded)) association bp(MESH:"Endoplasmic Reticulum Stress") - pmid:23383175 + pubmed:21722302 - path(MESH:"Neurologic Manifestations") association p(MGI:Stat3, pmod(Ph)) + p(MESH:Proteins, pmod(CONSO:misfolded)) increases act(p(HGNC:ERN1)) - pmid:23383175 + pubmed:21722302 - bp(HBP:Astrogliosis) negativeCorrelation a(GO:"myelin sheath") + p(MESH:Proteins, pmod(CONSO:misfolded)) increases act(p(HGNC:EIF2AK3)) - pmid:23383175 + pubmed:21722302 - bp(HBP:Microgliosis) negativeCorrelation a(GO:"myelin sheath") + p(MESH:Proteins, pmod(CONSO:misfolded)) increases act(p(HGNC:ATF6)) - pmid:23383175 + pubmed:21722302 - a(GO:"myelin sheath") positiveCorrelation a(CHEBI:Anatabine) + p(MESH:Proteins, pmod(CONSO:misfolded)) increases bp(CONSO:"protein aggregation") - pmid:23383175 + pubmed:21722302 - a(GO:"myelin sheath") negativeCorrelation a(MESH:Astrocytes) + p(MESH:Proteins, pmod(CONSO:misfolded)) increases bp(CONSO:"protein aggregation") - pmid:23383175 + pubmed:21722302 - a(GO:"myelin sheath") negativeCorrelation a(MESH:Microglia) + p(MESH:Proteins, pmod(CONSO:misfolded)) increases bp(MESH:"Unfolded Protein Response") - pmid:23383175 + pubmed:29758300 - a(GO:"myelin sheath") negativeCorrelation bp(HBP:Astrogliosis) + p(MESH:Proteins, pmod(CONSO:misfolded)) decreases bp(GO:"neuron cellular homeostasis") - pmid:23383175 + pubmed:29758300 - a(GO:"myelin sheath") negativeCorrelation bp(HBP:Microgliosis) + p(MESH:Proteins, pmod(CONSO:misfolded)) decreases a(MESH:Neurons) + + + + - pmid:12428809 + pubmed:29311797 - p(HGNC:MAPT, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) association path(MESH:"Alzheimer Disease") + deg(p(MESH:Proteins, pmod(CONSO:misfolded))) association a(MESH:"Molecular Chaperones") - pmid:21882945 + pubmed:27181519 - p(HGNC:MAPT, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(MESH:Proteins, pmod(CONSO:misfolded)) association path(DOID:"prion disease") - pmid:22299660 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation path(MESH:"Alzheimer Disease") + a(NCIT:C118474) increases bp(GO:"microglial cell activation") - pmid:29191965 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation path(MESH:"Alzheimer Disease") + a(NCIT:C118474) increases bp(GO:"microglial cell activation") - pmid:23088643 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation path(MESH:"Alzheimer Disease") + a(NCIT:C118474) increases bp(GO:"macrophage activation") - pmid:28784767 + pubmed:19126755 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) partOf p(HBP:"Tau epitope, AT8") + bp(GO:"establishment of blood-brain barrier") association a(MESH:Manduca) - pmid:23088643 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) partOf p(HBP:"Tau epitope, AT8") + p(HGNC:CSF1R) increases a(MESH:Pericytes) - pmid:25331948 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) partOf p(HBP:"Tau epitope, AT8") + a(MESH:"Leukocytes, Mononuclear", loc(NCIT:C74601)) isA a(MESH:"Antigen-Presenting Cells") - pmid:22833681 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) partOf p(HBP:"Tau epitope, AT8") + a(MESH:"Leukocytes, Mononuclear", loc(NCIT:C74601)) increases bp(GO:"T cell activation") - pmid:22817713 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) association a(HBP:"Tau aggregates") + a(MESH:"Leukocytes, Mononuclear") association path(DOID:"multiple sclerosis") - pmid:22817713 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) association a(HBP:"Tau oligomers") + a(MESH:"Antigen-Presenting Cells") increases bp(MESH:"Adaptive Immunity") - pmid:22486774 + pubmed:30988501 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) partOf a(HBP:"Tau oligomers") + a(MESH:"Antigen-Presenting Cells") increases bp(MESH:"Immunologic Surveillance") + + - pmid:14612456 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) isA p(HGNC:MAPT, pmod(Ph)) + a(NCIT:C156004) increases p(HGNC:IL6) - pmid:20071522 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) isA p(RGD:Mapt, pmod(Ph)) + a(NCIT:C156004) increases p(HGNC:IFNG) - pmid:20071522 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) association complex(p(HGNC:FKBP5), p(HGNC:MAPT)) + a(NCIT:C156004) increases p(MESH:Interleukin-23) - pmid:20071522 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(HGNC:FKBP5) + a(NCIT:C156004) increases p(HGNC:TNF) - pmid:21367866 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(HGNC:CDC37) + a(NCIT:C156004) increases p(HGNC:NOS2) - pmid:17078951 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(FPLX:PKA) + a(NCIT:C156004) increases p(HGNC:CCL4) - pmid:28784767 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) increases p(HBP:"Tau aggregates") + a(NCIT:C156004) increases p(HGNC:CCL5) - pmid:25331948 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) equivalentTo p(HBP:"Tau epitope, CP13") + a(NCIT:C156004) increases p(HGNC:CCL8) - pmid:19459590 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) decreases complex(a(MESH:Microtubules), p(HGNC:MAPT)) + a(NCIT:C156004) increases p(HGNC:CXCL2) - pmid:22833681 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) increases complex(p(HGNC:FYN), p(HGNC:MAPT)) + a(NCIT:C156004) increases p(HGNC:PF4) - pmid:22833681 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) + a(NCIT:C156004) increases p(HGNC:CXCL9) - pmid:24406748 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Ser")) + a(NCIT:C156004) isA a(MESH:"Antigen-Presenting Cells") - pmid:23294633 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) + a(NCIT:C156004) increases bp(MESH:"Adaptive Immunity") - pmid:22002427 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(HGNC:MAPT, var("p.Glu391*")) + a(NCIT:C156004) decreases p(MESH:Proteins, pmod(CONSO:misfolded)) - pmid:22253473 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) partOf a(GO:"neurofibrillary tangle") + a(NCIT:C123783) increases p(HGNC:IL4) - pmid:21734277 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(HBP:"phosphatase-activating domain") + a(NCIT:C123783) increases p(HGNC:IL10) - pmid:24653673 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Thr, 231)) decreases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:MAPT)) + a(NCIT:C123783) increases p(HGNC:IL13) - pmid:24653673 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Thr, 231)) positiveCorrelation path(MESH:"Alzheimer Disease") + a(NCIT:C123783) increases p(HGNC:TGFB1) - pmid:17403556 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Thr, 231)) positiveCorrelation path(MESH:"Alzheimer Disease") + a(NCIT:C123783) regulates bp(MESH:Immunity) - pmid:22253473 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Thr, 231)) positiveCorrelation path(MESH:"Alzheimer Disease") + a(NCIT:C123783) decreases path(MESH:Inflammation) - pmid:24653673 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Thr, 231)) decreases act(complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A))) + a(NCIT:C123783) increases bp(GO:"tissue remodeling") - pmid:24653673 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Thr, 231)) decreases act(complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A))) + a(NCIT:C123783) increases bp(GO:angiogenesis) - pmid:10391244 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Thr, 231)) association p(HGNC:PIN1, frag("5_39")) + a(NCIT:C123783) increases deg(a(MESH:Parasites)) - pmid:10391244 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Thr, 231)) negativeCorrelation act(p(HGNC:MAPT)) + a(NCIT:C123783) association a(MESH:"Th2 Cells") - pmid:21367866 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Thr, 231)) positiveCorrelation p(HGNC:CDC37) + a(NCIT:C123783) increases bp(GO:"regulatory T cell differentiation") - pmid:17078951 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Thr, 231)) positiveCorrelation p(FPLX:PKA) + a(NCIT:C123783, loc(MESH:"Spinal Cord")) increases bp(MESH:Remyelination) - pmid:23948915 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Thr, 231)) negativeCorrelation bp(GO:"apoptotic process") + p(MESH:Interleukin-23) increases path(MESH:Inflammation) - pmid:22833681 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Thr, 231)) equivalentTo p(HBP:"Tau epitope, AT180") + p(HGNC:CCL5) increases bp(GO:"inflammatory response") - pmid:22926167 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Thr, 231)) increases a(HBP:"Tau aggregates") + p(HGNC:CCL5) increases path(EFO:"experimental autoimmune encephalomyelitis") - pmid:22926167 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Thr, 231)) increases a(GO:"neurofibrillary tangle") + p(HGNC:CCL5) increases path(DOID:"multiple sclerosis") - pmid:27574109 + pubmed:30967783 - a(HBP:"Tau oligomers") association a(HBP:pretangles) + p(HGNC:CXCL2) increases bp(MESH:"Neutrophil Infiltration") - pmid:27574109 + pubmed:30967783 - a(HBP:"Tau oligomers") association a(HBP:"Braak_Stage I") + p(HGNC:CXCL2) increases path(EFO:"experimental autoimmune encephalomyelitis") - pmid:27574109 + pubmed:30967783 - a(HBP:"Tau oligomers") association a(HBP:"Braak_Stage II") + bp(GO:"detection of wounding") increases act(a(MESH:Microglia, loc(NCIT:C74601))) - pmid:27574109 + pubmed:30967783 - a(HBP:"Tau oligomers") association a(MESH:"Neurofibrillary Tangles") + bp(GO:"detection of wounding") increases act(a(MESH:Macrophages, loc(MESH:"Choroid Plexus"))) - pmid:27574109 + pubmed:30967783 - a(HBP:"Tau oligomers") association a(HBP:"Corticobasal Degeneration") + bp(GO:"detection of wounding") increases act(a(MESH:Macrophages, loc(NCIT:C83196))) - pmid:27574109 + pubmed:30967783 - a(HBP:"Tau oligomers") positiveCorrelation a(HBP:"Corticobasal Degeneration") + bp(GO:"detection of wounding") increases act(a(MESH:Macrophages, loc(MESH:Meninges))) + + - pmid:27574109 + pubmed:30967783 - a(HBP:"Tau oligomers") positiveCorrelation a(HBP:"Corticobasal Degeneration") + a(CHEBI:"2 L-glutamate") increases bp(GO:"excitatory postsynaptic potential") - pmid:27574109 + pubmed:30967783 - a(HBP:"Tau oligomers") association a(GO:"Pick body") + a(CHEBI:"2 L-glutamate", loc(MESH:Synapses)) directlyDecreases bp(MESH:"Synaptic Potentials") - pmid:27574109 + pubmed:30967783 - a(HBP:"Tau oligomers") positiveCorrelation path(MESH:Tauopathies) + a(CHEBI:"adenosine triphosphate", loc(MESH:Astrocytes)) increases bp(GO:"microglial cell activation") - pmid:29686391 + pubmed:30967783 - a(HBP:"Tau oligomers") positiveCorrelation path(MESH:Tauopathies) + p(HGNC:C1QA) negativeCorrelation act(a(MESH:Astrocytes)) - pmid:28420982 + pubmed:30967783 - a(HBP:"Tau oligomers") increases path(MESH:Tauopathies) + a(MESH:"Reactive Nitrogen Species") increases path(MESH:"Mitochondrial Degradation") - pmid:28420982 + pubmed:30967783 - a(HBP:"Tau oligomers") increases path(MESH:Tauopathies) + complex(a(MESH:Antigens), a(MESH:Microglia)) increases p(HGNCGENEFAMILY:"Histocompatibility complex") - pmid:27574109 + pubmed:30967783 - a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Alzheimer Disease") + complex(a(MESH:Antigens), a(MESH:Microglia)) increases bp(GO:"T cell activation") + + - pmid:27574109 + pubmed:30967783 - a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Alzheimer Disease") + p(MESH:"Histocompatibility Antigens Class II") causesNoChange path(DOID:"multiple sclerosis") - pmid:25887395 + pubmed:30967783 - a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:CCL2) increases bp(GO:"inflammatory response") - pmid:28420982 + pubmed:30967783 - a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:CCL2) increases path(EFO:"experimental autoimmune encephalomyelitis") - pmid:26631930 + pubmed:30967783 - a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:CCL2) increases path(DOID:"multiple sclerosis") - pmid:27574109 + pubmed:30967783 - a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Pick Disease of the Brain") + p(HGNC:CCL2) increases a(MESH:"Leukocytes, Mononuclear", loc(MESH:"Central Nervous System")) - pmid:27574109 + pubmed:26836182 - a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Pick Disease of the Brain") + p(HGNC:CCL2) positiveCorrelation path(CONSO:neuroinflammation) - pmid:28528849 + pubmed:26979166 - a(HBP:"Tau oligomers") decreases bp(GO:"long-term synaptic potentiation") + p(HGNC:CCL2) association path(MESH:Inflammation) - pmid:28528849 + pubmed:21718217 - a(HBP:"Tau oligomers") decreases bp(GO:memory) + p(HGNC:CCL2) increases bp(GO:"microglial cell activation") - pmid:28420982 + pubmed:30967783 - a(HBP:"Tau oligomers") decreases bp(GO:memory) + p(HGNC:TNFAIP3) regulates bp(GO:"microglial cell activation") - pmid:29191965 + pubmed:30967783 - a(HBP:"Tau oligomers") decreases a(MESH:Neurons) + p(HGNC:TNFAIP3) regulates bp(MESH:"Synaptic Potentials") - pmid:29686391 + pubmed:30967783 - a(HBP:"Tau oligomers") positiveCorrelation bp(HBP:neurotoxicity) + p(HGNC:TNFAIP3) decreases path(DOID:"multiple sclerosis") - pmid:22817713 + pubmed:30967783 - a(HBP:"Tau oligomers") increases bp(HBP:neurotoxicity) + p(HGNC:TREM2) increases bp(GO:"microglial cell activation") - pmid:22817713 + pubmed:30967783 - a(HBP:"Tau oligomers") increases bp(HBP:neurotoxicity) + p(HGNC:TREM2) decreases path(HP:"CNS demyelination") - pmid:29686391 + pubmed:30967783 - a(HBP:"Tau oligomers") positiveCorrelation tloc(a(HBP:"Tau oligomers"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(HGNC:TREM2) association path(MESH:Inflammation) - pmid:29686391 + pubmed:23533697 - tloc(a(HBP:"Tau oligomers"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) positiveCorrelation a(HBP:"Tau oligomers") + p(HGNC:TREM2) decreases path(MESH:Inflammation) + + - pmid:30985105 + pubmed:23533697 - a(HBP:"Tau oligomers") increases a(GO:"neurofibrillary tangle") + p(HGNC:TREM2) decreases bp(GO:"response to oxidative stress") - pmid:28420982 + pubmed:23533697 - a(HBP:"Tau oligomers") increases path(MESH:Disease) + p(HGNC:TREM2) decreases bp(GO:"response to oxidative stress") - pmid:28420982 + pubmed:23533697 - a(HBP:"Tau oligomers") increases bp(HP:Neurodegeneration) + p(HGNC:TREM2) association bp(GO:"inflammatory response") - pmid:28420982 + pubmed:23533697 - a(HBP:"Tau oligomers") increases bp(HP:Neurodegeneration) + p(HGNC:TREM2) decreases bp(GO:"inflammatory response") - pmid:22817713 + pubmed:23533697 - a(HBP:"Tau oligomers") increases bp(HP:Neurodegeneration) + p(HGNC:TREM2) increases bp(GO:phagocytosis) - pmid:28420982 + pubmed:29626319 - a(HBP:"Tau oligomers") increases path(MESH:"Brain Injuries, Traumatic") + p(HGNC:TREM2) association bp(GO:phagocytosis) - pmid:28420982 + pubmed:29626319 - a(HBP:"Tau oligomers") decreases a(GO:synapse) + p(HGNC:TREM2) increases bp(GO:phagocytosis) - pmid:28420982 + pubmed:23533697 - a(HBP:"Tau oligomers") increases a(HBP:"granular tau oligomers") + p(HGNC:TREM2) decreases bp(GO:"cytokine production") - pmid:28420982 + pubmed:23533697 - a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") + p(HGNC:TREM2) increases path(MESH:"Alzheimer Disease") + + - pmid:26631930 + pubmed:31413141 - a(HBP:"Tau oligomers") positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") + p(HGNC:TREM2) increases p(HGNC:TREM2, frag("?")) - pmid:28420982 + pubmed:31413141 - a(HBP:"Tau oligomers") decreases bp(GO:cognition) + p(HGNC:TREM2) causesNoChange p(HGNC:TREM2, frag("?")) + + + + - pmid:28420982 + pubmed:29758300 - a(HBP:"Tau oligomers") decreases bp(GO:"mitochondrion organization") + p(HGNC:TREM2) positiveCorrelation p(HGNC:MAPT) - pmid:28420982 + pubmed:29758300 - a(HBP:"Tau oligomers") decreases bp(GO:"maintenance of synapse structure") + p(HGNC:TREM2) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + - pmid:28420982 + pubmed:29758300 - a(HBP:"Tau oligomers") increases tloc(p(HGNC:MAPT), fromLoc(GO:"neuron part"), toLoc(GO:"neuron part")) + p(HGNC:TREM2) increases bp(GO:macroautophagy) - pmid:28420982 + pubmed:29758300 - a(HBP:"Tau oligomers") increases a(HBP:"Tau annular protofibrils") + p(HGNC:TREM2) increases bp(GO:"metabolic process") - pmid:28420982 + pubmed:29758300 - a(HBP:"Tau oligomers") decreases bp(MESH:"Cell Survival") + p(HGNC:TREM2) increases bp(GO:"metabolic process") - pmid:28420982 + pubmed:29758300 - a(HBP:"Tau oligomers") association p(HGNC:PRNP) + p(HGNC:TREM2) increases act(complex(GO:"TOR complex")) - pmid:28420982 + pubmed:29626319 - a(HBP:"Tau oligomers") decreases act(a(GO:microtubule)) + act(p(HGNC:TREM2)) increases deg(a(CHEBI:"amyloid-beta polypeptide 42")) - pmid:28420982 + pubmed:30967783 - a(HBP:"Tau oligomers") decreases a(MESH:"Electron Transport Complex I") + p(MESH:"Macrophage-1 Antigen") increases bp(GO:"microglial cell activation") - pmid:28420982 + pubmed:30967783 - a(HBP:"Tau oligomers") decreases act(a(MESH:"Electron Transport Complex I")) + p(HGNC:SRPRA) increases bp(GO:"microglial cell activation") - pmid:28420982 + pubmed:30967783 - a(HBP:"Tau oligomers") decreases bp(GO:"ATP synthesis coupled proton transport") + g(HGNC:PRSS3P2) increases bp(GO:neurogenesis) - pmid:28420982 + pubmed:30967783 - a(HBP:"Tau oligomers") increases act(p(HGNC:CASP9)) + p(NCIT:C20426) increases bp(GO:neurogenesis) - pmid:28420982 + pubmed:30967783 - a(HBP:"Tau oligomers") increases sec(p(HGNC:CYCS)) + p(MESH:Activins) increases bp(GO:"oligodendrocyte differentiation") - pmid:27373205 + pubmed:30967783 - a(HBP:"Tau oligomers") association p(HGNC:MAPT, pmod(Ph, Ser, 422)) + p(MESH:Activins) decreases bp(GO:"inflammatory response") - pmid:22817713 + pubmed:30967783 - a(HBP:"Tau oligomers") association p(HGNC:MAPT, pmod(Ph, Ser, 422)) + p(MESH:Activins) increases bp(MESH:Remyelination) - pmid:26631930 + pubmed:30967783 - a(HBP:"Tau oligomers") increases path(HBP:Neurodegeneration) + p(HGNC:TNFRSF1B) decreases path(EFO:"experimental autoimmune encephalomyelitis") - pmid:26631930 + pubmed:30967783 - a(HBP:"Tau oligomers") decreases a(MESH:"Dendritic Spines") + p(HGNC:TNFRSF1B) decreases a(MESH:"Leukocytes, Mononuclear", loc(MESH:"Central Nervous System")) - pmid:22817713 + pubmed:30967783 - a(HBP:"Tau oligomers") increases a(HBP:"Tau aggregates") + p(HGNC:TNFRSF1B) decreases path(HP:"CNS demyelination") - pmid:26751493 + pubmed:30967783 - a(HBP:"Tau oligomers") increases a(HBP:"Tau aggregates") + p(HGNC:TNFRSF1B) decreases bp(GO:"T cell activation") - pmid:22817713 + pubmed:30967783 - a(HBP:"Tau oligomers") association p(HGNC:MAPT, pmod(Ph, Ser, 202)) + p(HGNC:TRPM2) increases p(HGNC:CXCL2) - pmid:22817713 + pubmed:23702978 - a(HBP:"Tau oligomers") association p(HGNC:MAPT, pmod(Ph, Thr, 205)) + p(HGNC:TRPM2) increases act(p(HGNC:NLRP3)) - pmid:29238289 + pubmed:23702978 - a(HBP:"Tau oligomers") decreases path(MESH:Memory) + act(p(HGNC:TRPM2)) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) - pmid:29238289 + pubmed:30967783 - a(HBP:"Tau oligomers") decreases bp(MESH:"Long-Term Potentiation") + bp(GO:"T-helper 17 cell chemotaxis") positiveCorrelation p(HGNC:IL1B) - pmid:26671985 + pubmed:30967783 - act(a(HBP:"Tau oligomers")) increases path(HBP:neurotoxicity) + path(HP:Autoimmunity) positiveCorrelation p(HGNC:IL6) - pmid:26671985 + pubmed:30988501 - a(HBP:"Tau oligomers") positiveCorrelation path(HBP:neurotoxicity) + path(HP:Autoimmunity) increases path(CONSO:neuroinflammation) - pmid:26671985 + pubmed:30988501 - act(a(HBP:"Tau oligomers")) decreases act(complex(GO:axon)) + path(HP:Autoimmunity) increases path(MESH:Inflammation) - pmid:26671985 + pubmed:30988501 - a(HBP:"Tau oligomers") biomarkerFor path(MESH:"Chronic Traumatic Encephalopathy") + path(HP:Autoimmunity) increases path(DOID:"anxiety disorder") - pmid:27716675 + pubmed:30988501 - a(HBP:"Tau oligomers") positiveCorrelation path(HBP:neuroinflammation) + path(HP:Autoimmunity) increases path(DOID:"sleep disorder") - pmid:27716675 + pubmed:30988501 - a(HBP:"Tau oligomers") increases path(HBP:"Pathological Tau Spreading") + path(HP:Autoimmunity) increases path(HP:Mania) - pmid:27716675 + pubmed:30988501 - a(HBP:"Tau oligomers") increases path(HP:Neurodegeneration) + path(HP:Autoimmunity) increases path(HP:Paranoia) - pmid:22299660 + pubmed:30988501 - p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation path(MESH:"Alzheimer Disease") + path(HP:Autoimmunity) increases path(HP:"Memory impairment") - pmid:22419736 + pubmed:30988501 - p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation path(MESH:"Alzheimer Disease") + path(HP:Autoimmunity) increases path(MESH:"Language Disorders") - pmid:28420982 + pubmed:30988501 - p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation path(MESH:"Alzheimer Disease") + path(HP:Autoimmunity) increases path(HP:Agitation) - pmid:26458742 + pubmed:30988501 - p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation path(MESH:"Alzheimer Disease") + path(HP:Autoimmunity) increases path(MESH:Catatonia) - pmid:22611162 + pubmed:30988501 - p(HGNC:MAPT, pmod(Ph, Ser, 396)) association p(HGNC:MAPT, var("p.Val277Met")) + path(HP:Autoimmunity) increases path(HP:"Abnormality of movement") - pmid:28420982 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation path(MESH:"Frontotemporal Dementia") + p(HGNC:CCR4) decreases a(MESH:Macrophages) - pmid:14612456 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 396)) isA p(HGNC:MAPT, pmod(Ph)) + p(HGNC:CCR4) increases path(EFO:"experimental autoimmune encephalomyelitis") - pmid:20071522 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 396)) isA p(RGD:Mapt, pmod(Ph)) + p(HGNC:NR4A1) decreases a(DRUGBANK:Norepinephrine) - pmid:20071522 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 396)) association complex(p(HGNC:FKBP5), p(HGNC:MAPT)) + p(HGNC:NR4A1) decreases a(MESH:"Leukocytes, Mononuclear", loc(MESH:"Central Nervous System")) - pmid:20071522 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation p(HGNC:FKBP5) + p(HGNC:NR4A1) decreases path(EFO:"experimental autoimmune encephalomyelitis") - pmid:21367866 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation p(HGNC:CDC37) + a(CHEBI:"clondronate(2-)", loc(MESH:Liposomes)) decreases a(MESH:Macrophages) - pmid:22764226 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 396)) negativeCorrelation p(MGI:Ppp2ca, pmod(Me)) + a(CHEBI:"clondronate(2-)", loc(MESH:Liposomes)) decreases path(EFO:"experimental autoimmune encephalomyelitis") - pmid:17078951 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation p(FPLX:PKA) + p(HGNC:ICAM1) increases a(MESH:"Leukocytes, Mononuclear", loc(MESH:"Central Nervous System")) - pmid:22156579 + pubmed:30640040 - p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation p(HBP:"Tau epitope, PHF1") + p(HGNC:ICAM1) association a(PUBCHEM:9839311) - pmid:25331948 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 396)) partOf p(HBP:"Tau epitope, PHF1") + p(HGNC:CCL3) increases a(MESH:"Leukocytes, Mononuclear", loc(MESH:"Central Nervous System")) - pmid:22833681 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 396)) partOf p(HBP:"Tau epitope, PHF1") + p(MESH:"Nerve Growth Factors") decreases act(a(MESH:"Leukocytes, Mononuclear")) - pmid:23948915 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 396)) negativeCorrelation bp(GO:"apoptotic process") + p(MESH:"Nerve Growth Factors") decreases a(MESH:"Leukocytes, Mononuclear", loc(MESH:"Central Nervous System")) - pmid:19459590 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 396)) decreases complex(a(MESH:Microtubules), p(HGNC:MAPT)) + p(MESH:"Anti-Inflammatory Agents") decreases act(a(MESH:"Leukocytes, Mononuclear")) - pmid:22833681 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) + p(MESH:"Anti-Inflammatory Agents") decreases a(MESH:"Leukocytes, Mononuclear", loc(MESH:"Central Nervous System")) - pmid:25031639 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 396)) increases complex(p(HGNC:MAPT, pmod(Ph, Ser, 396)), p(HGNC:STUB1)) + a(MESH:"Choroid Plexus") increases a(NCIT:C123783, loc(MESH:"Spinal Cord")) - pmid:22299660 + pubmed:29626319 - p(HGNC:MAPT, pmod(Ph, Ser, 404)) positiveCorrelation path(MESH:"Alzheimer Disease") + a(MESH:"Choroid Plexus") increases a(MESH:"Cerebrospinal Fluid") - pmid:22419736 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 404)) positiveCorrelation path(MESH:"Alzheimer Disease") + a(DRUGBANK:"Ethyl pyruvate") association bp(GO:"macrophage activation") - pmid:26458742 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 404)) positiveCorrelation path(MESH:"Alzheimer Disease") + a(DRUGBANK:"Ethyl pyruvate") decreases bp(GO:"macrophage activation") - pmid:22611162 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 404)) association p(HGNC:MAPT, var("p.Val277Met")) + a(DRUGBANK:"Ethyl pyruvate") association bp(GO:"microglial cell activation") - pmid:24760868 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 404)) increases p(HGNC:MAPT, loc(MESH:"Dendritic Spines")) + a(DRUGBANK:"Ethyl pyruvate") decreases bp(GO:"microglial cell activation") - pmid:14612456 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 404)) isA p(HGNC:MAPT, pmod(Ph)) + a(DRUGBANK:"Ethyl pyruvate") decreases path(EFO:"experimental autoimmune encephalomyelitis") - pmid:21367866 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 404)) positiveCorrelation p(HGNC:CDC37) + a(CHEBI:spermidine) association bp(GO:"macrophage activation") - pmid:22764226 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 404)) negativeCorrelation p(MGI:Ppp2ca, pmod(Me)) + a(CHEBI:spermidine) association bp(GO:"microglial cell activation") - pmid:17078951 + pubmed:30116051 - p(HGNC:MAPT, pmod(Ph, Ser, 404)) negativeCorrelation p(FPLX:PKA) + a(CHEBI:spermidine) decreases p(HGNC:ATG7, pmod(go:0006473 ! "protein acetylation")) - pmid:11943212 + pubmed:30116051 - p(HGNC:MAPT, pmod(Ph, Ser, 404)) partOf p(HBP:"Tau epitope, AD2") + a(CHEBI:spermidine) decreases p(FPLX:"Histone_H3", pmod(go:0006473 ! "protein acetylation")) - pmid:22156579 + pubmed:30116051 - p(HGNC:MAPT, pmod(Ph, Ser, 404)) positiveCorrelation p(HBP:"Tau epitope, PHF1") + a(CHEBI:spermidine) increases act(p(HGNC:BECN1)) - pmid:25331948 + pubmed:30116051 - p(HGNC:MAPT, pmod(Ph, Ser, 404)) partOf p(HBP:"Tau epitope, PHF1") + a(CHEBI:spermidine) decreases act(p(HGNC:CASP3)) - pmid:22833681 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 404)) partOf p(HBP:"Tau epitope, PHF1") + a(CHEBI:"bryostatin 1") association bp(GO:"macrophage activation") - pmid:19459590 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 404)) decreases complex(a(MESH:Microtubules), p(HGNC:MAPT)) + a(CHEBI:"bryostatin 1") association bp(GO:"microglial cell activation") - pmid:25031639 + pubmed:30967783 - p(HGNC:MAPT, pmod(Ph, Ser, 404)) increases complex(p(HGNC:MAPT, pmod(Ph, Ser, 404)), p(HGNC:STUB1)) + a(CHEBI:forskolin) association bp(GO:"macrophage activation") - DOI:10.4172/2168-975X.1000126 + pubmed:30967783 - p(HGNC:GSK3B, pmod(Ph, Ser, 9)) decreases act(p(HGNC:GSK3B)) + a(CHEBI:forskolin) association bp(GO:"microglial cell activation") - pmid:25331948 + pubmed:30967783 - p(HGNC:GSK3B, pmod(Ph, Ser, 9)) decreases act(p(HGNC:GSK3B)) + a(CHEBI:forskolin) decreases p(HGNC:CD86) - pmid:22419736 + pubmed:30967783 - p(HGNC:GSK3B, pmod(Ph, Ser, 9)) decreases act(p(HGNC:GSK3B)) + a(CHEBI:forskolin) decreases path(EFO:"experimental autoimmune encephalomyelitis") - pmid:24183963 + pubmed:30967783 - p(HGNC:GSK3B, pmod(Ph, Ser, 9)) decreases act(p(HGNC:GSK3B), ma(kin)) + a(CHEBI:forskolin) increases p(HGNC:ARG1, loc(MESH:Macrophages)) - pmid:29121589 + pubmed:30967783 - p(HGNC:GSK3B, pmod(Ph, Ser, 9)) decreases act(p(HGNC:GSK3B), ma(kin)) + a(DRUGBANK:Lenalidomide) association bp(GO:"macrophage activation") - pmid:29844403 + pubmed:30967783 - p(HGNC:GSK3B, pmod(Ph, Ser, 9)) directlyDecreases act(p(HGNC:GSK3B)) + a(DRUGBANK:Lenalidomide) association bp(GO:"microglial cell activation") - DOI:10.4172/2168-975X.1000126 + pubmed:30967783 - p(FPLX:AKT, pmod(Ph, Ser, 473)) increases act(p(FPLX:AKT)) + p(HGNC:CD86) increases path(EFO:"experimental autoimmune encephalomyelitis") - pmid:23454242 + pubmed:30967783 - p(FPLX:AKT, pmod(Ph, Ser, 473)) increases act(p(FPLX:AKT)) + r(HGNC:GAS5) decreases a(MESH:Microglia) - pmid:29121589 + pubmed:30967783 - p(FPLX:AKT, pmod(Ph, Ser, 473)) increases act(p(FPLX:AKT)) + a(MESH:Glucocorticoids) decreases path(DOID:"relapsing-remitting multiple sclerosis") - pmid:29121589 + pubmed:30967783 - p(FPLX:AKT, pmod(Ph, Ser, 473)) positiveCorrelation a(CHEBI:"dimethyl fumarate") + a(MESH:Glucocorticoids) isA a(CHEBI:"immunosuppressive agent") - pmid:28391535 + pubmed:21718217 - sec(a(CHEBI:adrenaline)) increases sec(a(CHEBI:glucose)) + a(MESH:Glucocorticoids) decreases a(MESH:Macrophages) - pmid:28391535 + pubmed:30988501 - sec(a(CHEBI:adrenaline)) increases path(MESH:"Blood Pressure") + a(CHEBI:"immunosuppressive agent") decreases path(DOID:encephalitis) - pmid:28391535 + pubmed:28760828 - sec(a(CHEBI:adrenaline)) increases bp(GO:"cellular respiration") + p(HGNC:HDAC6) decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) - pmid:28391535 + pubmed:28760828 - sec(a(CHEBI:adrenaline)) increases bp(MESH:"Heart Rate") + p(HGNC:HDAC6) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) - pmid:22908190 + pubmed:25031639 - a(CHEBI:"insulin (human)") regulates p(HGNC:MTOR) + p(HGNC:HDAC6) decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) - - - - - pmid:28391535 + pubmed:25031639 - a(CHEBI:"(S)-nicotine") increases path(MESH:Death) + p(HGNC:HDAC6) regulates p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) - pmid:28391535 + pubmed:22372633 - a(CHEBI:"(R)-nicotine") increases path(MESH:Death) + p(HGNC:HDAC6) decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) - - - - - + + + pubmed:30935091 + + p(HGNC:HDAC6) decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) + - pmid:28391535 + pubmed:29661268 - a(MESH:Liver) increases bp(GO:"nicotine metabolic process") + act(p(HGNC:HDAC6)) decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation"), loc(CONSO:"KXGS motif")) - pmid:29626319 + pubmed:28760828 - a(MESH:Liver) increases deg(a(CHEBI:"amyloid-beta")) + p(HGNC:HDAC6) causesNoChange p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 290)) - pmid:29626319 + pubmed:28760828 - a(MESH:Liver) decreases a(CHEBI:"amyloid-beta") + act(p(HGNC:HDAC6)) association p(CONSO:"Tau aggregates") - pmid:29626319 + pubmed:22372633 - a(MESH:Liver) decreases a(CHEBI:"amyloid-beta") + act(p(HGNC:HDAC6), ma(GO:"deacetylase activity")) causesNoChange p(CONSO:"Tau aggregates") - pmid:29626319 + pubmed:30935091 - a(MESH:Liver) decreases a(CHEBI:"amyloid-beta polypeptide 40") + p(HGNC:HDAC6) increases p(CONSO:"Tau aggregates") - pmid:29626319 + pubmed:29661268 - a(MESH:Liver) causesNoChange a(CHEBI:"amyloid-beta polypeptide 42") + act(p(HGNC:HDAC6)) increases p(CONSO:"Tau aggregates") - pmid:28391535 + pubmed:28760828 - bp(GO:"nicotine metabolic process") increases a(CHEBI:"(-)-cotinine") + p(HGNC:HDAC6) increases p(HGNC:MAPT) - pmid:28391535 + pubmed:30935091 - bp(GO:"nicotine metabolic process") increases a(CHEBI:nornicotine) + act(p(HGNC:HDAC6)) increases act(p(HGNC:MAPT), ma(MESH:"Protein Transport")) - pmid:28391535 + pubmed:30935091 - a(MESH:Lung) increases bp(GO:"nicotine metabolic process") + p(HGNC:HDAC6) increases act(p(HGNC:MAPT), ma(GO:"microtubule binding")) - + + + pubmed:30935091 + + p(HGNC:HDAC6) increases p(HGNC:MAPT) + - + + + pubmed:29661268 + + act(p(HGNC:HDAC6)) decreases act(p(HGNC:MAPT), ma(GO:"microtubule binding")) + - pmid:26195256 + pubmed:28760828 - path(MESH:Hypertension) increases path(MESH:"Alzheimer Disease") + p(HGNC:HDAC6) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 324)) - + + + pubmed:28760828 + + act(p(HGNC:HDAC6)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 324)) + - pmid:28391535 + pubmed:25031639 - a(CHEBI:Hexamethonium) negativeCorrelation act(a(CHEBI:nicotine)) + p(HGNC:HDAC6) decreases act(p(HGNC:EP300)) - pmid:28391535 + pubmed:25031639 - a(CHEBI:"(-)-lobeline") increases complex(a(CHEBI:"(-)-lobeline"), a(MESH:"nicotinic receptor alpha4beta2")) + p(HGNC:HDAC6) increases p(HGNC:MAPT, pmod(CONSO:"protein aggregates")) - pmid:28391535 + pubmed:25031639 - a(CHEBI:"(-)-lobeline") decreases act(a(CHEBI:nicotine)) + act(p(HGNC:HDAC6)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) - pmid:28391535 + pubmed:25031639 - a(CHEBI:"(-)-lobeline") decreases act(a(CHEBI:methamphetamine)) + act(p(HGNC:HDAC6)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) - + + + pubmed:25031639 + + act(p(HGNC:HDAC6)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) + - + + + pubmed:25031639 + + act(p(HGNC:HDAC6)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) + - pmid:19165623 + pubmed:25031639 - complex(a(CHEBI:"1-methylpyrrolinium"), a(CHEBI:"nicotinic acid")) increases a(CHEBI:nicotine) + p(HGNC:HDAC6) positiveCorrelation path(DOID:tauopathy) - pmid:19165623 + pubmed:25031639 - a(CHEBI:arginine) increases a(CHEBI:"1-methylpyrrolinium") + p(HGNC:HDAC6) increases act(p(HGNC:MARK2)) - pmid:19165623 + pubmed:25031639 - a(CHEBI:ornithine) increases a(CHEBI:"1-methylpyrrolinium") + p(HGNC:HDAC6) decreases p(CONSO:"KXGS motif", pmod(go:0006473 ! "protein acetylation")) - pmid:19165623 + pubmed:25031639 - a(UNIPROT:Q9SEH4) increases a(CHEBI:nicotine) + act(p(HGNC:HDAC6)) decreases p(CONSO:"KXGS motif", pmod(go:0006473 ! "protein acetylation")) - pmid:19165623 + pubmed:25031639 - a(UNIPROT:Q9SEH4) increases a(CHEBI:nicotine) + p(HGNC:HDAC6) decreases p(CONSO:"KXGS motif", pmod(go:0006473 ! "protein acetylation")) - pmid:19165623 + pubmed:25031639 - a(UNIPROT:Q9SEH4) increases rxn(reactants(a(CHEBI:arginine), a(CHEBI:ornithine)), products(a(CHEBI:"1-methylpyrrolinium"))) + p(HGNC:HDAC6) regulates p(HGNC:MAPT, pmod(MESH:Polymerization)) - pmid:19165623 + pubmed:25031639 - a(UNIPROT:Q9SEH4) decreases a(CHEBI:Anatabine) + act(p(HGNC:HDAC6)) increases p(CONSO:"KXGS motif", pmod(go:0006468 ! "protein phosphorylation")) - + + + pubmed:25031639 + + act(p(HGNC:HDAC6)) negativeCorrelation act(complex(GO:microtubule), ma(GO:"microtubule motor activity")) + @@ -91715,118 +92517,108 @@

Statements

- pmid:19165623 + pubmed:25031639 - p(HGNC:QPRT) increases rxn(reactants(a(CHEBI:"quinolinic acid")), products(a(CHEBI:"nicotinic acid"))) + act(p(HGNC:HDAC6)) negativeCorrelation a(MESH:Microtubules) - pmid:19165623 + pubmed:22372633 - p(HGNC:QPRT) regulates rxn(reactants(a(CHEBI:"nicotinic acid")), products(a(CHEBI:Anatabine))) + p(HGNC:HDAC6) decreases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) - pmid:19165623 + pubmed:22372633 - p(HGNC:QPRT) increases a(CHEBI:Anatabine) + act(p(HGNC:HDAC6), ma(GO:"deacetylase activity")) decreases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) - pmid:19165623 + pubmed:22372633 - p(HGNC:QPRT) increases a(CHEBI:nicotine) + p(HGNC:HDAC6) decreases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) - - - - - - - - - pmid:22020111 + pubmed:22372633 - a(CHEBI:sulforaphane) increases act(p(HGNC:NFE2L2)) + p(HGNC:HDAC6) decreases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) - pmid:22020111 + pubmed:22372633 - a(CHEBI:sulforaphane) increases act(p(HGNC:NFE2L2)) + p(HGNC:HDAC6) decreases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) - pmid:22020111 + pubmed:22372633 - a(CHEBI:sulforaphane) increases act(p(HGNC:NFE2L2)) + p(HGNC:HDAC6) decreases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) - pmid:22020111 + pubmed:30935091 - a(CHEBI:sulforaphane) increases act(p(HGNC:NFE2L2)) + p(HGNC:HDAC6) decreases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) - - - pmid:22020111 + pubmed:30935091 - act(p(HGNC:NFE2L2)) negativeCorrelation path(MESH:"Kidney Diseases") + p(HGNC:HDAC6) decreases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) - pmid:22020111 + pubmed:30935091 - act(p(HGNC:NFE2L2)) negativeCorrelation path(MESH:"Multiple Sclerosis, Relapsing-Remitting") + p(HGNC:HDAC6) decreases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) - pmid:24563850 + pubmed:30935091 - p(HGNC:NFE2L2) increases bp(HBP:Proteostasis) + p(HGNC:HDAC6) decreases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation"), loc(MESH:Brain)) - pmid:29121589 + pubmed:30935091 - p(HGNC:NFE2L2) partOf complex(p(HGNC:CUL3), p(HGNC:KEAP1), p(HGNC:NFE2L2)) + p(HGNC:HDAC6) decreases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) @@ -91837,3166 +92629,3150 @@

Statements

- pmid:29121589 + pubmed:29661268 - p(HGNC:NFE2L2) positiveCorrelation p(FPLX:AKT) + p(HGNC:HDAC6) increases complex(p(HGNC:HDAC6), p(HGNC:MAPT)) - pmid:29121589 + pubmed:22372633 - p(HGNC:NFE2L2) negativeCorrelation act(p(HGNC:GSK3B)) + p(HGNC:HDAC6) negativeCorrelation bp(GO:"axonal transport of mitochondrion") - pmid:24355211 + pubmed:30935091 - p(HGNC:NFE2L2) increases p(ECCODE:"2.5.1.18") + p(HGNC:HDAC6) negativeCorrelation bp(GO:"axonal transport of mitochondrion") - pmid:22020111 + pubmed:22372633 - a(PUBCHEM:135316034) increases act(p(HGNC:NFE2L2)) + p(HGNC:HDAC6) decreases composite(a(MESH:Microtubules), p(MESH:Dyneins), p(MESH:Kinesin)) - pmid:22020111 + pubmed:22372633 - a(PUBCHEM:135316034) increases act(p(HGNC:NFE2L2)) + p(HGNC:HDAC6) positiveCorrelation bp(GO:"microtubule depolymerization") - pmid:22020111 + pubmed:22372633 - a(PUBCHEM:135316034) increases p(HGNC:NFE2L2) + p(HGNC:HDAC6) decreases complex(p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")), p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation"))) - pmid:22020111 + pubmed:22372633 - a(PUBCHEM:135316034) increases act(p(HGNC:NFE2L2)) + p(HGNC:HDAC6) increases p(MESH:Microtubules, pmod(go:0006473 ! "protein acetylation")) - pmid:22020111 + pubmed:22372633 - a(PUBCHEM:135316034) increases p(HGNC:SIRT1) + p(HGNC:HDAC6) decreases p(HGNC:MAPRE1) - pmid:22020111 + pubmed:22372633 - a(PUBCHEM:135316034) increases p(HGNC:SLC7A11) + p(HGNC:HDAC6) decreases p(HGNC:ACTR1A) + + - pmid:22020111 + pubmed:22372633 - a(PUBCHEM:135316034) increases p(HGNC:AKR1B10) + act(p(HGNC:HDAC6), ma(GO:"deacetylase activity")) decreases p(HGNC:PRX, pmod(go:0006473 ! "protein acetylation")) - pmid:22020111 + pubmed:22372633 - a(PUBCHEM:135316034) increases p(HGNC:PTGR1) + p(HGNC:HDAC6) decreases p(HGNC:HSF1) - pmid:22020111 + pubmed:22372633 - a(PUBCHEM:135316034) increases p(HGNC:HMOX1) + p(HGNC:HDAC6) increases act(p(HGNC:HSF1)) + + - pmid:22020111 + pubmed:22372633 - a(PUBCHEM:135316034) increases p(HGNC:HMOX1) + p(HGNC:HDAC6) decreases complex(p(HGNC:HDAC6), p(HGNC:HSF1), p(HGNCGENEFAMILY:"Heat shock 90kDa proteins")) - pmid:22020111 + pubmed:22372633 - a(PUBCHEM:135316034) increases p(HGNC:HMOX1) + p(HGNC:HDAC6) decreases act(p(HGNCGENEFAMILY:"Heat shock 90kDa proteins"), ma(GO:"vascular endothelial growth factor receptor 1 binding")) - pmid:22020111 + pubmed:29844403 - a(PUBCHEM:135316034) increases p(HGNC:AIFM2) + p(HGNC:HDAC6) association p(HGNCGENEFAMILY:"Heat shock 90kDa proteins") - pmid:22020111 + pubmed:22372633 - a(PUBCHEM:135316034) increases p(HGNC:OSGIN1) + p(HGNC:HDAC6) decreases p(HGNC:FLT1) - pmid:22020111 + pubmed:22372633 - a(PUBCHEM:135316034) increases p(HGNC:GPX3) + p(HGNC:HDAC6) decreases p(HGNC:KDR) - pmid:22020111 + pubmed:22372633 - a(PUBCHEM:135316034) increases p(HGNC:SQSTM1) + p(HGNC:HDAC6) decreases p(HGNCGENEFAMILY:"Heat shock 90kDa proteins", pmod(go:0006473 ! "protein acetylation")) - pmid:22020111 + pubmed:29844403 - a(PUBCHEM:135316034) increases p(HGNC:HSPB8) + p(HGNC:HDAC6) decreases p(HGNCGENEFAMILY:"Heat shock 90kDa proteins", pmod(go:0006473 ! "protein acetylation")) - pmid:22020111 + pubmed:30935091 - a(PUBCHEM:135316034) increases p(HGNC:TNFSF9) + p(HGNC:HDAC6) decreases p(HGNCGENEFAMILY:"Heat shock 90kDa proteins", pmod(go:0006473 ! "protein acetylation")) - pmid:22020111 + pubmed:22372633 - a(PUBCHEM:135316034) decreases p(HGNC:CTNNB1) + p(HGNC:HDAC6) causesNoChange bp(MESH:"Cell Survival") - pmid:22020111 + pubmed:22372633 - a(PUBCHEM:135316034) decreases p(HGNC:DHFR) + p(HGNC:HDAC6) decreases bp(MESH:"Cell Survival") - pmid:22020111 + pubmed:30935091 - a(PUBCHEM:135316034) decreases p(HGNC:DHFR) + p(HGNC:HDAC6) decreases bp(MESH:"Cell Survival") - pmid:22020111 + pubmed:22372633 - a(PUBCHEM:135316034) decreases p(HGNC:EDN1) + p(HGNC:HDAC6) causesNoChange bp(MESH:Growth) - pmid:22020111 + pubmed:22372633 - a(PUBCHEM:135316034) decreases p(HGNC:ITGB3) + p(HGNC:HDAC6) decreases p(CONSO:"protein aggregates", pmod(go:0016567 ! "protein ubiquitination")) - pmid:22020111 + pubmed:22372633 - a(PUBCHEM:135316034) decreases p(HGNC:MKI67) + p(HGNC:HDAC6) decreases bp(GO:"programmed cell death") - pmid:22020111 + pubmed:22372633 - a(PUBCHEM:135316034) decreases p(HGNC:MMP11) + p(HGNC:HDAC6) decreases path(DOID:"neurodegenerative disease") - pmid:22020111 + pubmed:22372633 - a(PUBCHEM:135316034) decreases p(HGNC:MMP14) + p(HGNC:HDAC6) decreases path(DOID:"neurodegenerative disease") - pmid:22020111 + pubmed:22372633 - a(PUBCHEM:135316034) decreases p(HGNC:MMP2) + p(HGNC:HDAC6) negativeCorrelation path(DOID:"neurodegenerative disease") - pmid:22020111 + pubmed:22372633 - a(PUBCHEM:135316034) decreases p(HGNC:PDE7A) + p(HGNC:HDAC6) increases bp(GO:"protein ubiquitination") + + - pmid:22020111 + pubmed:22372633 - a(PUBCHEM:135316034) decreases p(HGNC:PDE7B) + p(HGNC:HDAC6) increases p(HGNC:MAP1LC3A, loc(GO:aggresome)) - pmid:22020111 + pubmed:22372633 - a(PUBCHEM:135316034) decreases p(HGNC:PLAU) + p(HGNC:HDAC6) increases act(p(HGNC:CTTN), ma(GO:"actin filament binding")) - pmid:22020111 + pubmed:22372633 - a(PUBCHEM:135316034) decreases p(HGNC:PTGS1) + p(HGNC:HDAC6) increases bp(GO:"autophagosome-lysosome fusion") - pmid:22020111 + pubmed:27181519 - a(PUBCHEM:135316034) decreases p(HGNC:PTGS1) + p(HGNC:HDAC6) increases bp(GO:"autophagosome-lysosome fusion") - pmid:22020111 + pubmed:22372633 - a(PUBCHEM:135316034) decreases p(HGNC:SCARB1) + p(HGNC:HDAC6) positiveCorrelation bp(GO:"autophagosome maturation") - pmid:22020111 + pubmed:22372633 - a(PUBCHEM:135316034) decreases p(HGNC:TUBB3) + p(HGNC:HDAC6) decreases p(CONSO:"protein aggregates") + + - pmid:22020111 + pubmed:22372633 - a(PUBCHEM:135316034) decreases p(HGNC:TUBB3) + p(HGNC:HDAC6) increases bp(GO:"stress granule assembly") - pmid:22020111 + pubmed:27181519 - a(PUBCHEM:135316034) decreases p(HGNC:TUBB3) + p(HGNC:HDAC6) increases bp(GO:"stress granule assembly") - pmid:22020111 + pubmed:22372633 - a(PUBCHEM:135316034) increases p(HGNC:NR3C1) + p(HGNC:HDAC6) decreases path(MESH:"Bulbo-Spinal Atrophy, X-Linked") - pmid:22020111 + pubmed:22372633 - a(PUBCHEM:135316034) increases p(HGNC:NR3C1) + p(HGNC:HDAC6) decreases path(DOID:ciliopathy) + + - pmid:22020111 + pubmed:22372633 - a(PUBCHEM:135316034) increases p(HGNC:PPARA) + p(HGNC:HDAC6) increases p(CONSO:"alpha-synuclein aggregates") - pmid:22020111 + pubmed:22372633 - a(PUBCHEM:135316034) increases p(HGNC:PPARA) + p(HGNC:HDAC6) association bp(GO:autophagy) - pmid:22020111 + pubmed:18930136 - a(PUBCHEM:135316034) increases p(HGNC:EGR1) + p(HGNC:HDAC6) regulates bp(GO:autophagy) - pmid:22020111 + pubmed:18930136 - a(PUBCHEM:135316034) increases p(HGNC:PTGS2) + p(HGNC:HDAC6) increases bp(GO:autophagy) + + - pmid:22020111 + pubmed:22372633 - a(PUBCHEM:135316034) increases p(HGNC:PTGS2) + p(HGNC:HDAC6) positiveCorrelation bp(GO:"synaptic transmission, dopaminergic") - pmid:22020111 + pubmed:22372633 - a(PUBCHEM:135316034) increases p(HGNC:SOAT1) + p(HGNC:HDAC6) negativeCorrelation path(DOID:"retinal degeneration") - pmid:22020111 + pubmed:22372633 - a(PUBCHEM:135316034) decreases p(HGNC:ACLY) + p(HGNC:HDAC6) positiveCorrelation bp(MESH:Locomotion) - pmid:22020111 + pubmed:22372633 - a(PUBCHEM:135316034) decreases p(HGNC:ACLY) + p(HGNC:HDAC6) increases p(HGNC:SNCA, loc(GO:"inclusion body")) - pmid:22020111 + pubmed:22372633 - a(PUBCHEM:135316034) decreases p(HGNC:ANTXR1) + p(HGNC:HDAC6) negativeCorrelation bp(GO:"axonal transport") - pmid:22020111 + pubmed:22372633 - a(PUBCHEM:135316034) decreases p(HGNC:C20orf27) + p(HGNC:HDAC6) negativeCorrelation bp(GO:"axonal transport") - pmid:22020111 + pubmed:22372633 - a(PUBCHEM:135316034) decreases p(HGNC:CCNA2) + p(HGNC:HDAC6) causesNoChange path(DOID:"Huntington's disease") - pmid:22020111 + pubmed:22372633 - a(PUBCHEM:135316034) decreases p(HGNC:CHAF1A) + p(HGNC:HDAC6) positiveCorrelation path(DOID:"amyotrophic lateral sclerosis") - pmid:22020111 + pubmed:30935091 - a(PUBCHEM:135316034) decreases p(HGNC:EFCAB11) + p(HGNC:HDAC6) decreases path(DOID:"amyotrophic lateral sclerosis") - pmid:22020111 + pubmed:27181519 - a(PUBCHEM:135316034) decreases p(HGNC:FEN1) + act(p(HGNC:HDAC6)) negativeCorrelation path(DOID:"amyotrophic lateral sclerosis") - pmid:22020111 + pubmed:22372633 - a(PUBCHEM:135316034) decreases p(HGNC:GINS2) + p(HGNC:HDAC6) positiveCorrelation path(MESH:"Muscle Denervation") - pmid:22020111 + pubmed:22372633 - a(PUBCHEM:135316034) decreases p(HGNC:MCM10) + p(HGNC:HDAC6) decreases a(MESH:Axons) - pmid:22020111 + pubmed:22372633 - a(PUBCHEM:135316034) decreases p(HGNC:MCM4) + p(HGNC:HDAC6) increases p(HGNC:HSPB1, var("?")) + + - pmid:22020111 + pubmed:25546293 - a(PUBCHEM:135316034) decreases p(HGNC:RNASEH2A) + p(HGNC:HDAC6) decreases p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)) - pmid:22020111 + pubmed:25546293 - a(PUBCHEM:135316034) decreases p(HGNC:SLIT2) + act(p(HGNC:HDAC6)) decreases p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)) - pmid:22020111 + pubmed:25546293 - a(PUBCHEM:135316034) decreases p(HGNC:SPC25) + act(p(HGNC:HDAC6)) decreases p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)) - pmid:22020111 + pubmed:25546293 - a(PUBCHEM:135316034) decreases p(HGNC:TFRC) + p(HGNC:HDAC6) decreases p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)) - pmid:22020111 + pubmed:25546293 - a(PUBCHEM:135316034) decreases p(HGNC:TK1) + p(HGNC:HDAC6) causesNoChange p(HGNC:CTNNB1) - pmid:22020111 + pubmed:25546293 - a(PUBCHEM:135316034) decreases p(HGNC:TMEM97) + p(HGNC:HDAC6) decreases p(HGNC:CTNNB1, loc(GO:"plasma membrane")) - pmid:22020111 + pubmed:25546293 - a(PUBCHEM:135316034) decreases p(HGNC:TRIP13) + act(p(HGNC:HDAC6)) decreases p(HGNC:CTNNB1, loc(GO:nucleus)) - pmid:22020111 + pubmed:25546293 - a(PUBCHEM:135316034) decreases p(HGNC:TUBB) + act(p(HGNC:HDAC6)) decreases p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 45)) - pmid:22020111 + pubmed:25546293 - a(PUBCHEM:135316034) decreases p(HGNC:TUBB) + act(p(HGNC:HDAC6)) causesNoChange p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 33)) - pmid:22020111 + pubmed:25546293 - a(PUBCHEM:135316034) decreases p(HGNC:TYMS) + act(p(HGNC:HDAC6)) causesNoChange p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 37)) - pmid:22020111 + pubmed:25546293 - a(PUBCHEM:135316034) decreases p(HGNC:TYMS) + act(p(HGNC:HDAC6)) causesNoChange p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Thr, 41)) + + - pmid:22020111 + pubmed:25546293 - a(PUBCHEM:135316034) decreases p(HGNC:UBA1) + p(HGNC:HDAC6) decreases p(HGNC:HDAC6, pmod(go:0006473 ! "protein acetylation", Lys, 49)) + + - pmid:22020111 + pubmed:25546293 - a(PUBCHEM:135316034) decreases p(HGNC:UNG) + p(HGNC:HDAC6) decreases p(HGNC:HDAC6, pmod(go:0006473 ! "protein acetylation", Ser, 45)) - pmid:22020111 + pubmed:30935091 - a(PUBCHEM:135316034) decreases p(HGNC:UNG) + p(HGNC:HDAC6) increases path(MESH:"Nerve Degeneration") - pmid:22020111 + pubmed:30935091 - a(PUBCHEM:135316034) decreases p(HGNC:VRK1) + p(HGNC:HDAC6) increases act(a(CHEBI:"kainic acid")) - pmid:22020111 + pubmed:30935091 - a(PUBCHEM:135316034) increases p(HGNC:ABCD3) + p(HGNC:HDAC6) increases path(DOID:"axonal neuropathy") - pmid:22020111 + pubmed:30935091 - a(PUBCHEM:135316034) increases p(HGNC:GLRX2) + p(HGNC:HDAC6) decreases p(HGNC:SOD1, pmod(CONSO:"protein aggregates"), var("p.Gly93Ala")) - pmid:22020111 + pubmed:30935091 - a(PUBCHEM:135316034) increases p(HGNC:GLRX2) + p(HGNC:HDAC6) increases deg(p(HGNC:SOD1, pmod(CONSO:"protein aggregates"), var("p.Gly93Ala"), loc(GO:cytoplasm))) - pmid:22020111 + pubmed:30935091 - a(PUBCHEM:135316034) increases p(HGNC:MICB) + act(p(HGNC:HDAC6)) increases p(CONSO:"Tau fibrils") - pmid:22020111 + pubmed:30935091 - a(PUBCHEM:135316034) increases p(HGNC:NQO1) + p(HGNC:HDAC6) decreases bp(GO:"learning or memory") - pmid:22020111 + pubmed:30935091 - a(PUBCHEM:135316034) increases p(HGNC:NQO1) + p(HGNC:HDAC6) decreases bp(GO:"learning or memory") - pmid:22020111 + pubmed:30935091 - a(PUBCHEM:135316034) increases p(HGNC:NQO1) + p(HGNC:HDAC6) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 369)) - pmid:22020111 + pubmed:30935091 - a(PUBCHEM:135316034) decreases p(HGNC:AGRN) + p(HGNC:HDAC6) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) - pmid:22020111 + pubmed:30935091 - a(PUBCHEM:135316034) decreases p(HGNC:ANP32A) + p(HGNC:HDAC6) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:22020111 + pubmed:30935091 - a(PUBCHEM:135316034) decreases p(HGNC:BAX) + p(HGNC:HDAC6) decreases act(p(HGNC:AKT2)) - pmid:22020111 + pubmed:30935091 - a(PUBCHEM:135316034) decreases p(HGNC:BCHE) + p(HGNC:HDAC6) decreases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) + + - pmid:22020111 + pubmed:30935091 - a(PUBCHEM:135316034) decreases p(HGNC:BGN) + p(HGNC:HDAC6) increases p(HGNC:HDAC6, pmod(CONSO:"protein aggregates")) - pmid:22020111 + pubmed:30935091 - a(PUBCHEM:135316034) decreases p(HGNC:BRCA1) + p(HGNC:HDAC6) association bp(GO:"response to oxidative stress") - pmid:22020111 + pubmed:30935091 - a(PUBCHEM:135316034) decreases p(HGNC:CADPS2) + p(HGNC:HDAC6) decreases p(HGNC:HSPB1) - pmid:22020111 + pubmed:30935091 - a(PUBCHEM:135316034) decreases p(HGNC:CAPN1) + p(HGNC:HDAC6) decreases p(HGNCGENEFAMILY:"Heat shock 70kDa proteins") - pmid:22020111 + pubmed:30935091 - a(PUBCHEM:135316034) decreases p(HGNC:CCNB1) + p(HGNC:HDAC6) positiveCorrelation path(MESH:Depression) - pmid:22020111 + pubmed:30935091 - a(PUBCHEM:135316034) decreases p(HGNC:CDK1) + p(HGNC:HDAC6) decreases p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006473 ! "protein acetylation", Lys, 49)) - pmid:22020111 + pubmed:30935091 - a(PUBCHEM:135316034) decreases p(HGNC:CDK2) + p(HGNC:HDAC6) increases p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006468 ! "protein phosphorylation", Ser, 45)) - pmid:22020111 + pubmed:30935091 - a(PUBCHEM:135316034) decreases p(HGNC:CDKN2A) + p(HGNC:HDAC6) causesNoChange p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006468 ! "protein phosphorylation", Ser, 33)) - pmid:22020111 + pubmed:30935091 - a(PUBCHEM:135316034) decreases p(HGNC:CXCR4) + p(HGNC:HDAC6) causesNoChange p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006468 ! "protein phosphorylation", Ser, 37)) - pmid:22020111 + pubmed:30935091 - a(PUBCHEM:135316034) decreases p(HGNC:EIF4EBP1) + p(HGNC:HDAC6) causesNoChange p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006468 ! "protein phosphorylation", Thr, 41)) - pmid:22020111 + pubmed:30935091 - a(PUBCHEM:135316034) decreases p(HGNC:FOLH1) + p(HGNC:HDAC6) decreases p(HGNCGENEFAMILY:"Beta catenins", loc(GO:"plasma membrane")) - pmid:22020111 + pubmed:30935091 - a(PUBCHEM:135316034) decreases p(HGNC:HOMER1) + p(HGNC:HDAC6) association bp(GO:"synapse assembly") - pmid:22020111 + pubmed:30935091 - a(PUBCHEM:135316034) decreases p(HGNC:HRH1) + p(HGNC:HDAC6) decreases p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006473 ! "protein acetylation")) - pmid:22020111 + pubmed:30935091 - a(PUBCHEM:135316034) decreases p(HGNC:IGF2) + p(HGNC:HDAC6) decreases p(HGNC:AKT1, pmod(go:0006473 ! "protein acetylation", Lys, 163)) - pmid:22020111 + pubmed:30935091 - a(PUBCHEM:135316034) decreases p(HGNC:IGFBP2) + p(HGNC:HDAC6) decreases p(HGNC:AKT1, pmod(go:0006473 ! "protein acetylation", Lys, 377)) - pmid:22020111 + pubmed:30935091 - a(PUBCHEM:135316034) decreases p(HGNC:LDLR) + p(HGNC:HDAC6) decreases act(p(HGNC:AKT1), ma(GO:"phosphatidylinositol-3,4,5-trisphosphate binding")) - pmid:22020111 + pubmed:29661268 - a(PUBCHEM:135316034) decreases p(HGNC:MAOA) + act(p(HGNC:HDAC6)) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser), loc(CONSO:"KXGS motif")) - pmid:22020111 + pubmed:18930136 - a(PUBCHEM:135316034) decreases p(HGNC:NEFH) + p(HGNC:HDAC6) regulates bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:22020111 + pubmed:18930136 - a(PUBCHEM:135316034) decreases p(HGNC:NPDC1) + p(HGNC:HDAC6) regulates a(GO:aggresome) - pmid:22020111 + pubmed:18930136 - a(PUBCHEM:135316034) decreases p(HGNC:NRGN) + p(HGNC:HDAC6) increases tloc(p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination")), fromLoc(GO:cytoplasm), toLoc(GO:lysosome)) - pmid:22020111 + pubmed:18930136 - a(PUBCHEM:135316034) decreases p(HGNC:PREP) + p(HGNC:HDAC6) increases bp(GO:"Hsp90 deacetylation") - pmid:22020111 + pubmed:18930136 - a(PUBCHEM:135316034) decreases p(HGNC:PROS1) + p(HGNC:HDAC6) regulates complex(GO:"chaperone complex") - pmid:22020111 + pubmed:18930136 - a(PUBCHEM:135316034) decreases p(HGNC:SELENBP1) + p(HGNC:HDAC6) increases bp(GO:"ubiquitin-dependent protein catabolic process") - pmid:22020111 + pubmed:28803412 - a(PUBCHEM:135316034) decreases p(HGNC:TAGLN) + p(HGNC:HDAC6) decreases a(CONSO:CONSO00093) - pmid:22020111 + pubmed:30640040 - a(PUBCHEM:135316034) decreases p(HGNC:TGFB1) + p(HGNC:HDAC6) association a(PUBCHEM:53340666) - pmid:22020111 + pubmed:29311797 - a(PUBCHEM:135316034) decreases p(HGNC:VKORC1) + p(HGNC:HDAC6) increases act(p(HGNC:AIP)) - pmid:22020111 + pubmed:29311797 - a(PUBCHEM:135316034) increases p(HGNC:CANX) + p(HGNC:HDAC6) association a(CONSO:"Tau aggregates") - pmid:22020111 + pubmed:26751493 - a(PUBCHEM:135316034) increases p(HGNC:GCNT2) + p(HGNC:HDAC6) association p(CONSO:"microtubule-binding region") - pmid:22020111 + pubmed:26751493 - a(PUBCHEM:135316034) increases p(HGNC:IDE) + p(HGNC:HDAC6) association p(CONSO:"microtubule-binding region") - pmid:22020111 + pubmed:26631930 - a(PUBCHEM:135316034) increases p(HGNC:MMP1) + p(HGNC:HDAC6) decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys)) - pmid:22020111 + pubmed:23487739 - a(PUBCHEM:135316034) increases p(HGNC:SLC6A6) + p(HGNC:HDAC6) decreases a(GO:microtubule) + + + + - pmid:22020111 + pubmed:28760828 - a(PUBCHEM:135316034) increases p(HGNC:SYVN1) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) association p(CONSO:"Tau aggregates") - pmid:22020111 + pubmed:25031639 - a(PUBCHEM:135316034) increases p(HGNC:TSHZ1) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) decreases p(CONSO:"Tau aggregates") - pmid:22020111 + pubmed:28760828 - a(PUBCHEM:135316034) increases p(HGNC:TXN) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) regulates act(p(HGNC:MARK2)) - pmid:22020111 + pubmed:25031639 - a(PUBCHEM:135316034) decreases p(HGNC:ATAD2) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) positiveCorrelation p(HGNC:EP300) - pmid:22020111 + pubmed:25031639 - a(PUBCHEM:135316034) decreases p(HGNC:BECN1) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) decreases p(HGNC:MAPT, pmod(CONSO:"protein aggregates")) - pmid:22020111 + pubmed:25031639 - a(PUBCHEM:135316034) decreases p(HGNC:DHCR24) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) decreases p(HGNC:MAPT, pmod(CONSO:"Tau aggregates")) - pmid:22020111 + pubmed:25031639 - a(PUBCHEM:135316034) decreases p(HGNC:FGF2) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) decreases path(EFO:"microtubule-associated protein tau") - pmid:22020111 + pubmed:25031639 - a(PUBCHEM:135316034) decreases p(HGNC:HTRA1) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) increases deg(complex(a(MESH:Microtubules), p(HGNC:MAPT))) - pmid:22020111 + pubmed:25031639 - a(PUBCHEM:135316034) decreases p(HGNC:PRKCE) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) increases a(MESH:Microtubules) - pmid:22020111 + pubmed:25031639 - a(PUBCHEM:135316034) decreases p(HGNC:PRKDC) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) increases bp(GO:"axonal transport") - pmid:22020111 + pubmed:25031639 - a(PUBCHEM:135316034) decreases p(HGNC:SCD) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) association p(CONSO:"KXGS motif", pmod(go:0006468 ! "protein phosphorylation")) - pmid:22020111 + pubmed:30935091 - a(PUBCHEM:135316034) increases p(HGNC:ATP1A1) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) decreases p(HGNC:MAPT) - pmid:22020111 + pubmed:29661268 - a(PUBCHEM:135316034) increases p(HGNC:CTSD) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) association p(HGNC:MAPT, var("p.Lys?Gln")) - pmid:22020111 + pubmed:29661268 - a(PUBCHEM:135316034) increases p(HGNC:GLRX) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) association p(HGNC:MAPT, var("p.Lys280Gln")) - pmid:22020111 + pubmed:20869593 - a(PUBCHEM:135316034) increases p(HGNC:GLRX) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:22020111 + pubmed:20869593 - a(PUBCHEM:135316034) increases p(HGNC:IL6R) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:22020111 + pubmed:24027553 - a(PUBCHEM:135316034) increases p(HGNC:NPTX1) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) association path(MESH:"Neurofibrillary Tangles") - pmid:22020111 + pubmed:27041503 - a(PUBCHEM:135316034) increases p(HGNC:PHF1) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) negativeCorrelation p(HGNC:WWC1) - pmid:22020111 + pubmed:20869593 - a(PUBCHEM:135316034) increases p(HGNC:PRKCD) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) positiveCorrelation p(CONSO:"Tau epitope, AT8") - pmid:22020111 + pubmed:28760828 - a(PUBCHEM:135316034) increases p(HGNC:RANBP9) + a(PUBCHEM:57381425) decreases act(p(HGNC:HDAC6)) - pmid:22020111 + pubmed:30935091 - a(PUBCHEM:135316034) increases p(HGNC:SOD1) + a(PUBCHEM:57381425) decreases p(HGNC:HDAC6) - pmid:22020111 + pubmed:28760828 - a(PUBCHEM:135316034) increases p(HGNC:SOD1) + a(PUBCHEM:57381425) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) - pmid:22020111 + pubmed:30935091 - a(PUBCHEM:400769) increases act(p(HGNC:NFE2L2)) + a(PUBCHEM:57381425) increases bp(GO:"axonal transport") - pmid:22020111 + pubmed:30935091 - a(PUBCHEM:400769) increases act(p(HGNC:NFE2L2)) + a(PUBCHEM:57381425) positiveCorrelation bp(GO:"axonal transport") - pmid:22020111 + pubmed:30935091 - a(PUBCHEM:400769) increases act(p(HGNC:NFE2L2)) + a(PUBCHEM:57381425) positiveCorrelation bp(GO:"axonal transport") - pmid:22020111 + pubmed:30935091 - a(PUBCHEM:400769) increases act(p(HGNC:NFE2L2)) + a(PUBCHEM:57381425) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:22020111 + pubmed:30935091 - a(PUBCHEM:400769) increases bp(GO:"glomerular filtration") + a(PUBCHEM:57381425) increases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) - pmid:22020111 + pubmed:30935091 - a(PUBCHEM:400769) negativeCorrelation path(MESH:"Multiple Sclerosis, Relapsing-Remitting") + a(PUBCHEM:57381425) decreases path(MESH:"Amyloid Neuropathies") - pmid:22020111 + pubmed:30935091 - a(CHEBI:"dimethyl fumarate") increases act(p(HGNC:NFE2L2)) + a(PUBCHEM:57381425) increases bp(GO:"learning or memory") - pmid:22020111 + pubmed:29661268 - a(CHEBI:"dimethyl fumarate") increases act(p(HGNC:NFE2L2)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 290), loc(CONSO:"KXGS motif")) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser), pmod(go:0006468 ! "protein phosphorylation", Thr), loc(CONSO:"microtubule-binding region")) - pmid:22020111 + pubmed:29661268 - a(CHEBI:"dimethyl fumarate") increases act(p(HGNC:NFE2L2)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 290), loc(CONSO:"KXGS motif")) decreases p(CONSO:"Tau aggregates") - pmid:22020111 + pubmed:26631930 - a(CHEBI:"dimethyl fumarate") causesNoChange act(p(HGNC:NFE2L2)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 290)) increases deg(p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 290))) - pmid:22020111 + pubmed:26631930 - a(CHEBI:"dimethyl fumarate") increases act(p(HGNC:NFE2L2)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 290)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:29121589 + pubmed:26631930 - a(CHEBI:"dimethyl fumarate") increases p(FPLX:ERK, pmod(Ph)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 290)) decreases a(CONSO:"Tau aggregates") - pmid:29121589 + pubmed:28760828 - a(CHEBI:"dimethyl fumarate") increases p(FPLX:p38, pmod(Ph)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Gln, 259), pmod(go:0006473 ! "protein acetylation", Gln, 290), pmod(go:0006473 ! "protein acetylation", Gln, 321), pmod(go:0006473 ! "protein acetylation", Gln, 353), var("p.Lys259Gln"), var("p.Lys290Gln"), var("p.Lys321Gln"), var("p.Lys352Gln")) negativeCorrelation p(CONSO:"Tau aggregates") - pmid:29121589 + pubmed:28760828 - a(CHEBI:"dimethyl fumarate") positiveCorrelation p(FPLX:AKT, pmod(Ph, Ser, 473)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Gln, 290), pmod(go:0006473 ! "protein acetylation", Gln, 321), var("p.Lys290Gln"), var("p.Lys321Gln")) decreases p(CONSO:"Tau aggregates") - pmid:29121589 + pubmed:28760828 - a(CHEBI:"dimethyl fumarate") increases p(MGI:Gsk3b, pmod(Ph, Ser, 9)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Gln, 321), var("p.Lys321Gln")) decreases p(CONSO:"Tau fibrils") - pmid:29121589 + pubmed:21427723 - a(CHEBI:"dimethyl fumarate") decreases act(p(MGI:Gsk3b)) + p(CONSO:"Tau fibrils") decreases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation")) - pmid:29121589 + pubmed:22372633 - a(CHEBI:"dimethyl fumarate") decreases p(MGI:Mapt, pmod(Ph)) + p(CONSO:"Tau fibrils") increases p(HGNC:HDAC6) - pmid:29121589 + pubmed:22372633 - a(CHEBI:"dimethyl fumarate") decreases p(MGI:Dpysl2, pmod(Ph)) + p(CONSO:"Tau fibrils") increases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) + + - pmid:29121589 + pubmed:30108137 - a(CHEBI:"dimethyl fumarate") decreases path(HBP:Astrogliosis) + p(CONSO:"Tau fibrils", loc(MESH:Lysosomes)) increases deg(p(CONSO:"Tau fibrils")) - pmid:29121589 + pubmed:30108137 - a(CHEBI:"dimethyl fumarate") decreases path(HBP:Microgliosis) + p(CONSO:"Tau fibrils", loc(MESH:Lysosomes)) increases deg(p(CONSO:"Tau fibrils")) + + - pmid:29121589 + pubmed:29238289 - a(CHEBI:"dimethyl fumarate") decreases r(MGI:Il1b) + p(CONSO:"Tau fibrils") increases tloc(p(HGNC:MAPT)) - pmid:29121589 + pubmed:28760828 - a(CHEBI:"dimethyl fumarate") decreases r(MGI:Nos2) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Gln, 163), var("p.Lys163Gln")) causesNoChange p(CONSO:"Tau aggregates") - pmid:29121589 + pubmed:28760828 - a(CHEBI:"dimethyl fumarate") decreases bp(GO:"inflammatory response") + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Gln, 174), var("p.Lys174Gln")) causesNoChange p(CONSO:"Tau aggregates") - pmid:22020111 + pubmed:28760828 - p(HGNC:SLC7A11) regulates bp(GO:"glutamate homeostasis") + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Gln, 180), var("p.Lys180Gln")) causesNoChange p(CONSO:"Tau aggregates") - pmid:22020111 + pubmed:28760828 - p(HGNC:SLC7A11) increases tloc(a(CHEBI:cystine), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Gln, 234), var("p.Lys234Gln")) causesNoChange p(CONSO:"Tau aggregates") - pmid:22020111 + pubmed:28760828 - p(HGNC:AKR1B10) increases bp(GO:detoxification) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Gln, 240), var("p.Lys240Gln")) causesNoChange p(CONSO:"Tau aggregates") - pmid:22020111 + pubmed:28760828 - p(HGNC:AKR1B10) decreases a(PUBCHEM:5283344) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Gln, 274), var("p.Lys274Gln")) decreases p(CONSO:"Tau aggregates") - pmid:22020111 + pubmed:28760828 - p(HGNC:PTGR1) decreases act(a(MESH:Prostaglandins)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Gln, 280), var("p.Lys280Gln")) causesNoChange p(CONSO:"Tau aggregates") - pmid:22020111 + pubmed:28760828 - p(HGNC:PTGR1) decreases act(a(MESH:Eicosanoids)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Gln, 311), var("p.Lys311Gln")) causesNoChange p(CONSO:"Tau aggregates") - pmid:22020111 + pubmed:28760828 - p(HGNC:AIFM2) negativeCorrelation path(MESH:Neoplasms) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Gln, 369), var("p.Lys369Gln")) causesNoChange p(CONSO:"Tau aggregates") - pmid:22020111 + pubmed:28760828 - p(HGNC:GPX3) negativeCorrelation path(MESH:Neoplasms) + p(HGNC:MAPT, var("p.Lys321Arg")) decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) - pmid:22020111 + pubmed:28760828 - p(HGNC:SQSTM1) increases bp(GO:autophagy) + p(HGNC:MAPT, var("p.Lys321Arg")) causesNoChange p(CONSO:"Tau fibrils") - pmid:22908190 + pubmed:28760828 - p(HGNC:SQSTM1) increases bp(GO:autophagy) + p(HGNC:MAPT, var("p.Lys321Gln")) decreases p(CONSO:"Tau aggregates") - pmid:18930136 + pubmed:28760828 - p(HGNC:SQSTM1) regulates bp(GO:autophagy) + p(HGNC:MAPT, var("p.Lys321Gln")) decreases p(CONSO:"Tau fibrils") - pmid:18930136 + pubmed:28760828 - p(HGNC:SQSTM1) increases bp(GO:autophagy) + composite(p(HGNC:MAPT), p(HGNC:MARK2)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 324)) - pmid:18930136 + pubmed:28760828 - p(HGNC:SQSTM1) increases bp(GO:autophagy) + composite(p(HGNC:MAPT), p(HGNC:MARK2)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262), pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) - pmid:22020111 + pubmed:25374103 - p(HGNC:SQSTM1) decreases bp(GO:"stress-induced premature senescence") + composite(p(HGNC:MAPT), p(HGNC:MARK2)) positiveCorrelation bp(GO:"anterograde axonal transport") + + + + - pmid:29758300 + pubmed:25031639 - p(HGNC:SQSTM1) increases deg(p(HGNC:MAPT)) + p(HGNC:MARK2) increases p(CONSO:"KXGS motif", pmod(go:0006468 ! "protein phosphorylation")) - pmid:29758300 + pubmed:25031639 - p(HGNC:SQSTM1) decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + act(p(HGNC:MARK2)) increases p(CONSO:"KXGS motif", pmod(go:0006468 ! "protein phosphorylation")) - pmid:29758300 + pubmed:25031639 - p(HGNC:SQSTM1) increases p(HGNC:SYP) + p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) - pmid:29758300 + pubmed:29215007 - p(HGNC:SQSTM1) regulates bp(GO:"short-term memory") + act(p(HGNC:MARK2), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) - pmid:22908190 + pubmed:29215007 - p(HGNC:SQSTM1) association bp(GO:"proteasomal protein catabolic process") + p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) - pmid:18930136 + pubmed:21311567 - p(HGNC:SQSTM1) regulates bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + act(p(HGNC:MARK2)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) - pmid:18930136 + pubmed:24251416 - p(HGNC:SQSTM1) increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + act(p(HGNC:MARK2), ma(go:0016301 ! "kinase activity")) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) - pmid:18930136 + pubmed:25031639 - p(HGNC:SQSTM1) regulates a(GO:aggresome) + p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) - pmid:18930136 + pubmed:23001711 - p(HGNC:SQSTM1) association a(GO:"Lewy body") + act(p(HGNC:MARK2), ma(go:0016301 ! "kinase activity")) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) - pmid:18930136 + pubmed:25031639 - p(HGNC:SQSTM1) association a(GO:"neurofibrillary tangle") + p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 365)) - pmid:18930136 + pubmed:29215007 - p(HGNC:SQSTM1) association a(MESH:"Huntingtin Protein") + act(p(HGNC:MARK2), ma(go:0016301 ! "kinase activity")) increases p(CONSO:CONSO00098, pmod(go:0006468 ! "protein phosphorylation")) - pmid:18930136 + pubmed:29215007 - p(HGNC:SQSTM1) association p(HGNC:SOD1, var("?")) + p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 293)) - pmid:18930136 + pubmed:24251416 - p(HGNC:SQSTM1) increases deg(p(MESH:Proteins, pmod(Ub))) + act(p(HGNC:MARK2), ma(go:0016301 ! "kinase activity")) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 293)) - pmid:18930136 + pubmed:29215007 - p(HGNC:SQSTM1) increases bp(GO:"ubiquitin-dependent protein catabolic process") + p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 305)) - pmid:30116051 + pubmed:24251416 - p(HGNC:SQSTM1) association path(MESH:"Frontotemporal Dementia") + act(p(HGNC:MARK2), ma(go:0016301 ! "kinase activity")) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 305)) - pmid:30116051 + pubmed:29215007 - p(HGNC:SQSTM1) association path(MESH:"Amyotrophic Lateral Sclerosis") + p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 324)) - - - pmid:22020111 + pubmed:24251416 - p(HGNC:HSPB8) increases complex(p(HGNC:BAG3), p(HGNC:HSPB8)) + act(p(HGNC:MARK2), ma(go:0016301 ! "kinase activity")) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 324)) - pmid:27491084 + pubmed:29215007 - p(HGNC:HSPB8) association a(HBP:"amyloid-beta aggregates") + p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) - pmid:24563850 + pubmed:24251416 - p(HGNC:HSPB8) increases bp(GO:"chaperone-mediated autophagy") + act(p(HGNC:MARK2), ma(go:0016301 ! "kinase activity")) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) - pmid:24563850 + pubmed:25031639 - p(HGNC:HSPB8) association p(HGNC:EIF2A) + p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) - + + + pubmed:29215007 + + p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 416)) + - pmid:22020111 + pubmed:24251416 - complex(p(HGNC:BAG3), p(HGNC:HSPB8)) positiveCorrelation bp(GO:autophagy) + act(p(HGNC:MARK2), ma(go:0016301 ! "kinase activity")) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 416)) - pmid:22020111 + pubmed:21882945 - complex(p(HGNC:BAG3), p(HGNC:HSPB8)) increases deg(a(HBP:"protein aggregates")) + act(p(HGNC:MARK2)) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:23746257 + pubmed:21882945 - p(HGNC:BAG3) increases bp(GO:macroautophagy) + act(p(HGNC:MARK2)) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + - pmid:25036637 + pubmed:21311567 - p(HGNC:BAG3) increases complex(p(HGNC:BAG3), p(HGNC:HSPB8)) + act(p(HGNC:MARK2)) decreases bp(GO:"microtubule polymerization") - pmid:25036637 + pubmed:24251416 - p(HGNC:BAG3) increases complex(p(HGNC:BAG3), p(HGNC:HSPB1)) + act(p(HGNC:MARK2), ma(go:0016301 ! "kinase activity")) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 352)) - pmid:25036637 + pubmed:24251416 - p(HGNC:BAG3) directlyIncreases complex(p(HGNC:BAG3), p(HGNC:HSPB1)) + act(p(HGNC:MARK2), ma(go:0016301 ! "kinase activity")) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 413)) - pmid:25036637 + pubmed:28760828 - p(HGNC:BAG3) increases complex(p(HGNC:BAG3), p(HGNC:HSF1)) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 324)) increases p(CONSO:"Tau aggregates") - pmid:25036637 + pubmed:17493042 - p(HGNC:BAG3) directlyIncreases complex(p(HGNC:BAG3), p(HGNC:DCP1B)) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 324)) decreases p(CONSO:"Tau aggregates") - pmid:29626319 + pubmed:29215007 - p(HGNC:BAG3) increases deg(p(HGNC:MAPT)) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 324)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) - pmid:22020111 + pubmed:29215007 - p(HGNC:TNFSF9) increases act(a(MESH:"Dendritic Cells")) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 324)) decreases bp(GO:"actin filament bundle assembly") - pmid:22020111 + pubmed:17493042 - p(HGNC:TNFSF9) increases bp(GO:"T cell activation") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 324)) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) - pmid:22020111 + pubmed:17493042 - path(MESH:Atherosclerosis) increases p(HGNC:CTNNB1) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 324)) decreases bp(GO:"neurofibrillary tangle assembly") - pmid:22020111 + pubmed:30145931 - path(MESH:Atherosclerosis) increases p(HGNC:DHFR) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262), pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) positiveCorrelation a(CONSO:"amyloid-beta oligomers") - pmid:22020111 + pubmed:30145931 - path(MESH:Atherosclerosis) increases p(HGNC:EDN1) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262), pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) positiveCorrelation a(CHEBI:wortmannin) - pmid:22020111 + pubmed:30145931 - path(MESH:Atherosclerosis) increases p(HGNC:ITGB3) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262), pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) positiveCorrelation a(CHEBI:epoxomicin) - pmid:22020111 + pubmed:28760828 - path(MESH:Atherosclerosis) increases p(HGNC:MKI67) + composite(p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation"), var("p.Lys321Gln")), p(HGNC:MARK2)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 324)) - pmid:22020111 + pubmed:28760828 - path(MESH:Atherosclerosis) increases p(HGNC:MMP11) + composite(p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation"), var("p.Lys321Gln")), p(HGNC:MARK2)) causesNoChange p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262), pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) + + - pmid:22020111 + pubmed:21427723 - path(MESH:Atherosclerosis) increases p(HGNC:MMP14) + bp(GO:"microtubule polymerization") negativeCorrelation p(MGI:Mapt, var("p.Lys280del")) - pmid:22020111 + pubmed:30061532 - path(MESH:Atherosclerosis) increases p(HGNC:MMP2) + bp(GO:"microtubule polymerization") increases bp(GO:"cytoskeleton organization") - pmid:22020111 + pubmed:29238289 - path(MESH:Atherosclerosis) increases p(HGNC:PDE7A) + bp(GO:"microtubule polymerization") association p(HGNC:MAPT) - pmid:22020111 + pubmed:20133804 - path(MESH:Atherosclerosis) increases p(HGNC:PDE7B) + bp(GO:"microtubule polymerization") positiveCorrelation complex(GO:microtubule) - pmid:22020111 + pubmed:2123288 - path(MESH:Atherosclerosis) increases p(HGNC:PLAU) + bp(GO:"microtubule polymerization") increases a(MESH:Microtubules) - pmid:22020111 + pubmed:28760828 - path(MESH:Atherosclerosis) increases p(HGNC:PTGS1) + p(HGNC:MAPT, var("p.Ser324Ala")) increases bp(GO:"microtubule polymerization") - pmid:22020111 + pubmed:28760828 - path(MESH:Atherosclerosis) increases p(HGNC:SCARB1) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"), var("p.Ser324Asp")) decreases bp(GO:"microtubule polymerization") - pmid:22020111 + pubmed:28760828 - path(MESH:Atherosclerosis) increases p(HGNC:TUBB3) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"), var("p.Ser324Glu")) decreases bp(GO:"microtubule polymerization") - pmid:22020111 + pubmed:28760828 - path(MESH:Atherosclerosis) decreases p(HGNC:NR3C1) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) decreases bp(GO:"microtubule polymerization") + + - pmid:22020111 + pubmed:25031639 - path(MESH:Atherosclerosis) decreases p(HGNC:PPARA) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) decreases complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)), p(HGNC:STUB1)) - pmid:22020111 + pubmed:25031639 - path(MESH:Atherosclerosis) increases p(HGNC:EGR1) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) decreases complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)), p(HGNC:STUB1)) - pmid:22020111 + pubmed:25031639 - path(MESH:Atherosclerosis) increases p(HGNC:PTGS2) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) decreases deg(p(HGNC:MAPT)) - pmid:22020111 + pubmed:22299660 - path(MESH:Atherosclerosis) increases p(HGNC:SOAT1) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:22020111 + pubmed:29758300 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:ACLY) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:22020111 + pubmed:26751493 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:ANTXR1) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:22020111 + pubmed:29758300 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:C20orf27) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) increases bp(GO:autophagy) - pmid:22020111 + pubmed:29215007 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:CCNA2) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) - pmid:22020111 + pubmed:29215007 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:CHAF1A) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) decreases bp(GO:"actin filament bundle assembly") - pmid:22020111 + pubmed:29215007 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:DHFR) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) decreases bp(GO:"actin filament bundle assembly") - pmid:22020111 + pubmed:29215007 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:EFCAB11) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_284"))) - pmid:22020111 + pubmed:25374103 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:FEN1) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) negativeCorrelation composite(p(CONSO:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) - pmid:22020111 + pubmed:26631930 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:GINS2) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) - pmid:22020111 + pubmed:26631930 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:MCM10) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) decreases complex(p(HGNC:MAPT), p(HGNC:STUB1)) - pmid:22020111 + pubmed:26631930 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:MCM4) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) decreases deg(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356))) - pmid:22020111 + pubmed:17493042 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:RNASEH2A) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) - pmid:22020111 + pubmed:17493042 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:SLIT2) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) decreases p(CONSO:"Tau aggregates") - pmid:22020111 + pubmed:17493042 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:SPC25) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) decreases bp(GO:"neurofibrillary tangle assembly") - pmid:22020111 + pubmed:21367866 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:TFRC) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) positiveCorrelation p(HGNC:CDC37) - pmid:22020111 + pubmed:11943212 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:TK1) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) association p(HGNC:MARK4, pmod(go:0006468 ! "protein phosphorylation")) + + - pmid:22020111 + pubmed:22692785 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:TMEM97) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) partOf a(GO:"neurofibrillary tangle") - pmid:22020111 + pubmed:22156579 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:TRIP13) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) partOf p(CONSO:"Tau epitope, 12E8") + + + + - pmid:22020111 + pubmed:23948915 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:TUBB) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) negativeCorrelation bp(GO:"apoptotic process") - pmid:22020111 + pubmed:22833681 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:TUBB3) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) positiveCorrelation p(HGNC:MAPT, pmod(CONSO:O-GlcNAcylation)) - pmid:22020111 + pubmed:22952452 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:TYMS) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) decreases complex(a(MESH:Microtubules), p(HGNC:MAPT)) - pmid:22020111 + pubmed:22952452 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:UBA1) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) positiveCorrelation path(CONSO:Neurodegeneration) - pmid:22020111 + pubmed:28760828 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:UNG) + p(HGNC:MAPT, var("p.Pro301Leu")) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:22020111 + pubmed:28760828 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:VRK1) + p(HGNC:MAPT, var("p.Pro301Leu")) decreases deg(p(HGNC:MAPT)) - pmid:22020111 + pubmed:29844403 - path(MESH:"Colorectal Neoplasms") decreases p(HGNC:ABCD3) + p(HGNC:MAPT, var("p.Pro301Leu")) increases p(HGNC:MAPT, loc(GO:cytosol)) - pmid:22020111 + pubmed:29844403 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:GLRX2) + p(HGNC:MAPT, var("p.Pro301Leu")) increases p(HGNC:MAPT, loc(CONSO:"Tau aggregates")) - pmid:22020111 + pubmed:29844403 - path(MESH:"Colorectal Neoplasms") positiveCorrelation p(HGNC:GLRX2) + p(HGNC:MAPT, var("p.Pro301Leu")) increases p(HGNC:MAPT) - pmid:22020111 + pubmed:28760828 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:MICB) + p(HGNC:MAPT, var("p.Pro301Leu")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 324)) - pmid:22020111 + pubmed:29844403 - path(MESH:"Colorectal Neoplasms") increases p(HGNC:NQO1) + p(HGNC:MAPT, var("p.Pro301Leu")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) - pmid:22020111 + pubmed:29844403 - path(MESH:"Colorectal Neoplasms") positiveCorrelation p(HGNC:NQO1) + p(HGNC:MAPT, var("p.Pro301Leu")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) - pmid:22020111 + pubmed:29844403 - path(MESH:"Colorectal Neoplasms") positiveCorrelation bp(MESH:"Oxidative Stress") + p(HGNC:MAPT, var("p.Pro301Leu")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) - pmid:25036637 + pubmed:29844403 - p(HGNC:MCM4) increases bp(GO:"DNA replication initiation") + p(HGNC:MAPT, var("p.Pro301Leu")) increases complex(p(HGNC:HDAC6), p(HGNCGENEFAMILY:"Heat shock 90kDa proteins")) - pmid:25036637 + pubmed:29844403 - p(HGNC:MCM4) increases bp(GO:"replication fork progression beyond termination site") + p(HGNC:MAPT, var("p.Pro301Leu")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) - pmid:14556719 + pubmed:29844403 - act(p(HGNC:UBA1)) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAPT, var("p.Pro301Leu")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) - pmid:18930136 + pubmed:29844403 - p(HGNC:UBA1) increases bp(GO:autophagy) + p(HGNC:MAPT, var("p.Pro301Leu")) causesNoChange p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) - pmid:18930136 + pubmed:29844403 - p(HGNC:UBA1) increases bp(GO:"protein ubiquitination") + p(HGNC:MAPT, var("p.Pro301Leu")) causesNoChange p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) - pmid:29626319 + pubmed:18583940 - p(HGNC:UBA1) increases deg(a(MESH:Proteins)) + p(HGNC:MAPT, var("p.Pro301Leu")) increases path(MESH:"Chromosome Aberrations") - pmid:25673844 + pubmed:24027553 - p(HGNC:VRK1) isA p(HBP:"CK1 superfamily") + p(HGNC:MAPT, var("p.Pro301Leu")) association path(MESH:"Frontotemporal Dementia") - pmid:22020111 + pubmed:26751493 - p(HGNC:GLRX2) positiveCorrelation path(MESH:"Colorectal Neoplasms") + p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation path(MESH:"Frontotemporal Dementia") - pmid:22020111 + pubmed:23294633 - p(HGNC:NQO1) positiveCorrelation path(MESH:"Colorectal Neoplasms") + p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation path(MESH:"Frontotemporal Dementia") - pmid:22020111 + pubmed:26631930 - p(HGNC:NQO1) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAPT, var("p.Pro301Leu")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) - pmid:24653673 + pubmed:26631930 - p(HGNC:ANP32A) decreases act(complex(GO:"protein phosphatase type 2A complex")) + p(HGNC:MAPT, var("p.Pro301Leu")) increases a(CONSO:"Tau aggregates") - pmid:24653673 + pubmed:26631930 - p(HGNC:ANP32A) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) + p(HGNC:MAPT, var("p.Pro301Leu")) increases a(CONSO:"Tau aggregates") - pmid:24653673 + pubmed:26631930 - p(HGNC:ANP32A) increases complex(p(HGNC:ANP32A), p(HGNC:PPP2CA)) + p(HGNC:MAPT, var("p.Pro301Leu")) decreases bp(GO:memory) - pmid:24653673 + pubmed:29121589 - p(HGNC:ANP32A) increases complex(p(HGNC:ANP32A), p(HGNC:PPP2CB)) + p(HGNC:MAPT, var("p.Pro301Leu")) increases r(MGI:Il1b) - pmid:24653673 + pubmed:29121589 - p(HGNC:ANP32A) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAPT, var("p.Pro301Leu")) increases r(MGI:Nos2) - pmid:22299660 + pubmed:23294633 - p(HGNC:ANP32A) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(MGI:Gsk3b, pmod(go:0006468 ! "protein phosphorylation", Tyr, 279)) - pmid:22299660 + pubmed:23294633 - p(HGNC:ANP32A) decreases act(p(FPLX:PPP2)) + p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(MGI:Gsk3b, pmod(go:0006468 ! "protein phosphorylation", Tyr, 216)) - pmid:30116051 + pubmed:23294633 - p(HGNC:CAPN1) decreases bp(GO:autophagy) + p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) - pmid:30116051 + pubmed:23294633 - p(HGNC:CAPN1) decreases deg(p(HGNC:HTT, var("?"))) + p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) - pmid:10391244 + pubmed:23294633 - act(p(HGNC:CDK1)) increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) + p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 212)) - pmid:10391244 + pubmed:23294633 - p(HGNC:CDK1) positiveCorrelation complex(GO:"neurofibrillary tangle") + p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 214)) - pmid:12428809 + pubmed:23294633 - p(HGNC:CDK2) increases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) - pmid:8282104 + pubmed:11606569 - p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(CONSO:"VQIINK motif") - pmid:8282104 + pubmed:11606569 - p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 199)) + p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(CONSO:"VQIVYK motif") - pmid:8282104 + pubmed:27716675 - p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 199)) + p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation path(CONSO:neuroinflammation) - pmid:8282104 + pubmed:28760828 - p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 321)) decreases p(CONSO:"Tau aggregates") - pmid:8282104 + pubmed:29661268 - p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 321), loc(CONSO:"KXGS motif")) decreases p(CONSO:"Tau aggregates") - pmid:8282104 + pubmed:28760828 - p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 235)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 321)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 324)) - pmid:8282104 + pubmed:29661268 - p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 235)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 321), loc(CONSO:"KXGS motif")) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 324), loc(CONSO:"microtubule-binding region")) - pmid:22072628 + pubmed:29661268 - act(p(HGNC:CDK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 235)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 321), loc(CONSO:"KXGS motif")) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser), pmod(go:0006468 ! "protein phosphorylation", Thr), loc(CONSO:"microtubule-binding region")) - pmid:8282104 + pubmed:26631930 - p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 321)) increases deg(p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 321))) - pmid:8282104 + pubmed:26631930 - p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 321)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:8282104 + pubmed:26631930 - p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 321)) decreases a(CONSO:"Tau aggregates") - pmid:8282104 + pubmed:26192747 - p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 321)) isA p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) - pmid:22072628 + pubmed:26192747 - p(HGNC:CDK2) increases p(HBP:"Tau epitope, AT180") + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 321)) partOf p(CONSO:"microtubule-binding region") - pmid:22072628 + pubmed:21427723 - act(p(HGNC:CDK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Thr, 212)) + p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation")) increases p(CONSO:"Tau fibrils") - pmid:22072628 + pubmed:21427723 - act(p(HGNC:CDK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Thr, 217)) + p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation")) association composite(p(MGI:Crebbp), p(MGI:Hdac6)) - - - pmid:26195256 + pubmed:21427723 - p(HGNC:FOLH1) increases deg(a(CHEBI:"amyloid-beta", loc(GO:"extracellular region"))) + p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation")) association p(MGI:Mapt, var("p.Lys280del")) - pmid:24027553 + pubmed:21427723 - act(p(HGNC:HTRA1)) increases deg(p(HGNC:MAPT)) + p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation")) decreases complex(a(MESH:Microtubules), p(MGI:Mapt)) - pmid:24027553 + pubmed:21427723 - act(p(HGNC:HTRA1)) increases deg(p(HGNC:MAPT)) + p(MGI:Mapt, frag("?")) decreases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys)) - pmid:29626319 + pubmed:21427723 - p(HGNC:HTRA1) increases deg(p(HGNC:MAPT)) + p(MGI:Mapt, frag("?")) positiveCorrelation bp(GO:"tubulin complex assembly") - pmid:24027553 + pubmed:21427723 - p(HGNC:HTRA1) association bp(HBP:"APP processing") + p(MGI:Mapt, frag("?")) decreases p(CONSO:"Tau fibrils") - pmid:24027553 + pubmed:21427723 - p(HGNC:HTRA1) association path(MESH:"Alzheimer Disease") + p(MGI:Crebbp) increases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation")) - pmid:24027553 + pubmed:21427723 - act(p(HGNC:HTRA1)) increases deg(p(HGNCGENEFAMILY:Tubulins)) + p(MGI:Crebbp) increases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation")) - pmid:24027553 + pubmed:21427723 - act(p(HGNC:HTRA1)) regulates act(a(MESH:Microtubules)) + p(MGI:Crebbp) increases p(MGI:Mapt, frag("?"), pmod(go:0006473 ! "protein acetylation", Lys)) - - - pmid:24027553 - - act(p(HGNC:HTRA1)) increases deg(a(HBP:"Tau fibrils")) - - - - - pmid:24027553 - - act(p(HGNC:HTRA1)) increases deg(a(HBP:"Tau aggregates")) - - - - - pmid:22020111 - - p(HGNC:GLRX) positiveCorrelation path(MESH:"Alzheimer Disease") - - - pmid:23702978 + pubmed:21427723 - act(p(HGNC:PRKCD), ma(kin)) increases p(HGNC:NLRC4, pmod(Ph, Ser)) + p(MGI:Crebbp) increases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 280), pmod(go:0006473 ! "protein acetylation", Lys, 281)) - pmid:22020111 + pubmed:21427723 - p(HGNC:SOD1) positiveCorrelation path(MESH:"Alzheimer Disease") + p(MGI:Crebbp) increases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 163)) - - - pmid:14556719 + pubmed:21427723 - p(HGNC:SOD1) decreases bp(GO:"response to oxidative stress") + p(MGI:Crebbp) increases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 396)) - - - - - - - - - pmid:24563850 + pubmed:21427723 - p(HGNC:SOD1) increases rxn(reactants(a(CHEBI:superoxide)), products(a(CHEBI:"hydrogen peroxide"), a(CHEBI:dioxygen))) + bp(GO:"tubulin complex assembly") positiveCorrelation p(MGI:Mapt, frag("?")) - - - pmid:22020111 + pubmed:21427723 - path(MESH:"Kidney Diseases") negativeCorrelation act(p(HGNC:NFE2L2)) + bp(GO:"tubulin complex assembly") negativeCorrelation p(MGI:Mapt, frag("?"), pmod(go:0006473 ! "protein acetylation")) - pmid:22020111 + pubmed:21427723 - path(MESH:"Multiple Sclerosis, Relapsing-Remitting") negativeCorrelation a(PUBCHEM:400769) + bp(GO:"tubulin complex assembly") negativeCorrelation p(MGI:Mapt, frag("?"), var("p.Lys311Asp")) - pmid:22020111 + pubmed:21427723 - path(MESH:"Multiple Sclerosis, Relapsing-Remitting") negativeCorrelation act(p(HGNC:NFE2L2)) + p(MGI:Mapt, frag("?"), pmod(go:0006473 ! "protein acetylation")) negativeCorrelation bp(GO:"tubulin complex assembly") - pmid:23454242 + pubmed:21427723 - bp(GO:phosphorylation) regulates bp(GO:"cell division") + p(MGI:Mapt, frag("?"), pmod(go:0006473 ! "protein acetylation")) increases p(CONSO:"Tau fibrils") - pmid:23454242 + pubmed:21427723 - bp(GO:phosphorylation) regulates bp(GO:"cell growth") + p(MGI:Mapt, frag("?"), var("p.Lys311Asp")) negativeCorrelation bp(GO:"tubulin complex assembly") - pmid:23454242 + pubmed:21427723 - bp(GO:phosphorylation) regulates bp(GO:"cell development") + p(MGI:Mapt, frag("?"), var("p.Lys311Asp")) decreases act(p(MGI:Mapt), ma(GO:"microtubule binding")) - pmid:23454242 + pubmed:21427723 - bp(GO:phosphorylation) increases bp(GO:"negative regulation of apoptotic process") + p(MGI:Mapt, frag("?"), var("p.Lys311Asp")) decreases p(CONSO:"Tau fibrils") - pmid:23454242 + pubmed:21427723 - bp(GO:phosphorylation) regulates bp(GO:"cell population proliferation") + a(CHEBI:"trichostatin A") decreases p(MESH:"Histone Deacetylases") - pmid:23454242 + pubmed:21427723 - bp(GO:phosphorylation) regulates bp(GO:"apoptotic process") + a(CHEBI:"trichostatin A") increases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation")) - - - pmid:21882945 - - bp(GO:phosphorylation) regulates a(HBP:"Hsp27 oligomers") - - - pmid:25784053 + pubmed:27209302 - bp(GO:"cell division") association p(FPLX:"CCT_complex") + a(CHEBI:"trichostatin A") increases p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation")) - pmid:23454242 + pubmed:27209302 - p(FPLX:PPP2) regulates bp(GO:"glycolytic process") + a(CHEBI:"trichostatin A") decreases p(HGNC:HDAC1) - pmid:23454242 + pubmed:27209302 - p(FPLX:PPP2) regulates bp(GO:"lipid metabolic process") + a(CHEBI:"trichostatin A") decreases p(HGNC:HDAC2) - pmid:23454242 + pubmed:27209302 - p(FPLX:PPP2) regulates bp(GO:"catecholamine biosynthetic process") + a(CHEBI:"trichostatin A") decreases p(HGNC:HDAC4) - pmid:23454242 + pubmed:27209302 - p(FPLX:PPP2) regulates bp(GO:"cell cycle") + a(CHEBI:"trichostatin A") increases p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation", Lys, 116)) - pmid:23454242 + pubmed:27209302 - p(FPLX:PPP2) regulates bp(GO:"DNA replication") + a(CHEBI:"trichostatin A") causesNoChange p(HGNC:TFEB, var("p.Lys116Arg")) - pmid:23454242 + pubmed:27209302 - p(FPLX:PPP2) regulates bp(GO:"transcription, DNA-templated") + a(CHEBI:"trichostatin A") causesNoChange bp(GO:"microglial cell activation") - pmid:23454242 + pubmed:21427723 - p(FPLX:PPP2) regulates bp(GO:translation) + a(CHEBI:"trichostatin A") directlyDecreases act(p(FPLX:HDAC)) - pmid:23454242 + pubmed:21427723 - p(FPLX:PPP2) regulates bp(GO:"signal transduction") + a(CHEBI:"trichostatin A") increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) - pmid:23454242 + pubmed:27209302 - p(FPLX:PPP2) regulates bp(GO:"cell population proliferation") + p(MESH:"Histone Deacetylases") causesNoChange deg(p(HGNC:SIRT1)) - pmid:23454242 + pubmed:21427723 - p(FPLX:PPP2) regulates bp(GO:"cell population proliferation") + a(CHEBI:nicotinamide) decreases p(MGI:Sirt1) - pmid:23454242 + pubmed:21427723 - p(FPLX:PPP2) regulates bp(GO:"cytoskeleton organization") + a(CHEBI:nicotinamide) decreases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation")) - pmid:23454242 + pubmed:27209302 - p(FPLX:PPP2) increases bp(GO:"cytoskeleton organization") + a(CHEBI:nicotinamide) increases p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation")) - pmid:23454242 + pubmed:27209302 - p(FPLX:PPP2) regulates bp(GO:"cell motility") + a(CHEBI:nicotinamide) increases p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation")) - pmid:23454242 + pubmed:27209302 - p(FPLX:PPP2) regulates bp(GO:"apoptotic process") + a(CHEBI:nicotinamide) decreases p(HGNCGENEFAMILY:Sirtuins) - pmid:23454242 + pubmed:27209302 - p(FPLX:PPP2) regulates bp(GO:"apoptotic process") + a(CHEBI:nicotinamide) increases p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation", Lys, 116)) - pmid:23454242 + pubmed:27209302 - p(FPLX:PPP2) association path(MESH:"Cell Transformation, Neoplastic") + a(CHEBI:nicotinamide) causesNoChange p(HGNC:TFEB, var("p.Lys116Arg")) - pmid:23454242 + pubmed:27209302 - p(FPLX:PPP2) association path(MESH:Neoplasms) + a(CHEBI:nicotinamide) decreases act(p(HGNC:SIRT1)) - - - pmid:23454242 - - p(FPLX:PPP2) decreases path(MESH:Neoplasms) - - - pmid:23454242 + pubmed:29540553 - act(p(FPLX:PPP2)) negativeCorrelation path(MESH:Neoplasms) + p(MGI:Sirt1) decreases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation")) - pmid:22299660 + pubmed:29540553 - p(FPLX:PPP2) association path(MESH:Neoplasms) + p(MGI:Sirt1) decreases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 163)) - - - - - - - pmid:23454242 + pubmed:29540553 - p(FPLX:PPP2) decreases p(HGNC:VIM, pmod(Ph)) + p(MGI:Sirt1) decreases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 174)) - pmid:23454242 + pubmed:29540553 - act(p(FPLX:PPP2)) decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + p(MGI:Sirt1) decreases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 174)) - pmid:22299660 + pubmed:29540553 - act(p(FPLX:PPP2)) negativeCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + p(MGI:Sirt1) decreases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 274)) - - - pmid:23454242 + pubmed:29540553 - act(p(FPLX:PPP2)) association p(FPLX:PPP2, pmod(Me)) + p(MGI:Sirt1) decreases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 280)) - - - pmid:23454242 + pubmed:29540553 - act(p(FPLX:PPP2)) association p(FPLX:PPP2, pmod(Ph)) + p(MGI:Sirt1) decreases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 369)) - - - - - pmid:23454242 + pubmed:29540553 - p(FPLX:PPP2) decreases p(FPLX:AKT, pmod(Ph, Thr, 308)) + p(MGI:Sirt1) causesNoChange p(MGI:Mapt, var("p.Pro301Ser")) - pmid:23454242 + pubmed:29540553 - p(FPLX:PPP2) association bp(GO:"Wnt signaling pathway") + p(MGI:Sirt1) decreases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 174), var("p.Pro301Ser")) - pmid:23454242 + pubmed:29540553 - p(FPLX:PPP2) decreases p(HGNC:CTNNB1, pmod(Ph)) + p(MGI:Sirt1) decreases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 174), var("p.Pro301Ser")) - pmid:23454242 + pubmed:29540553 - p(FPLX:PPP2) increases deg(p(HGNC:CTNNB1)) + p(MGI:Sirt1) causesNoChange p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 274), var("p.Pro301Ser")) - pmid:23454242 + pubmed:29540553 - p(FPLX:PPP2) decreases p(HGNC:BAD, pmod(Ph)) + p(MGI:Sirt1) decreases path(MESH:"Mortality, Premature") - pmid:23454242 + pubmed:29540553 - p(FPLX:PPP2) decreases p(HGNC:BCL2, pmod(Ph)) + p(MGI:Sirt1) causesNoChange p(MGI:Syp) @@ -95005,193 +95781,183 @@

Statements

- pmid:12428809 + pubmed:29540553 - p(FPLX:PPP2) decreases p(HGNC:MAPT, pmod(Ph)) + p(MGI:Sirt1) increases path(MESH:"Neuronal Plasticity") - pmid:22299660 + pubmed:29540553 - p(FPLX:PPP2) association a(MESH:Cytosol) + p(MGI:Sirt1) causesNoChange p(MESH:"Neurofibrillary Tangles") - pmid:22299660 + pubmed:29540553 - p(FPLX:PPP2) association a(MESH:"Cell Nucleus") + p(MGI:Sirt1) decreases path(EFO:"behavioural disinhibition measurement") - pmid:22299660 + pubmed:29540553 - p(FPLX:PPP2) association a(MESH:Mitochondria) + p(MGI:Sirt1) decreases path(EFO:tauopathy) - pmid:22299660 + pubmed:29540553 - p(FPLX:PPP2) association a(MESH:Cytoskeleton) + p(MGI:Sirt1) decreases a(MESH:Synapses) - pmid:22299660 + pubmed:29540553 - p(FPLX:PPP2) association a(MESH:"Cell Membrane") + p(MGI:Sirt1) increases bp(GO:behavior) - pmid:22299660 + pubmed:29540553 - p(FPLX:PPP2) association path(MESH:"Frontotemporal Dementia") + p(MGI:Sirt1) negativeCorrelation path(MESH:Tauopathies) - - - pmid:22299660 - - act(p(FPLX:PPP2)) negativeCorrelation a(HBP:"paired helical filaments") - - - pmid:22299660 + pubmed:21427723 - act(p(FPLX:PPP2)) decreases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) + composite(a(CHEBI:"trichostatin A"), p(MGI:Crebbp)) increases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation")) - pmid:22299660 + pubmed:21427723 - act(p(FPLX:PPP2)) decreases p(HGNC:MAPT, pmod(Ph, Ser, 42)) + composite(p(MGI:Crebbp), p(MGI:Hdac6)) association p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation")) - - - pmid:22299660 - - act(p(FPLX:PPP2)) decreases act(p(HGNC:CDK5)) - + - pmid:22299660 + pubmed:21427723 - act(p(FPLX:PPP2)) decreases act(p(HGNC:TPK1)) + p(MGI:Hdac6) increases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 280)) - pmid:22299660 + pubmed:21427723 - act(p(FPLX:PPP2)) decreases act(p(HGNC:GSK3B)) + composite(p(MGI:Crebbp), p(MGI:Hdac6, var("?"))) causesNoChange p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation")) + + - pmid:22299660 + pubmed:21427723 - act(p(FPLX:PPP2)) negativeCorrelation path(MESH:"Alzheimer Disease") + p(MGI:Mapt, var("p.Lys163Arg"), var("p.Lys280Arg"), var("p.Lys281Arg"), var("p.Lys369Arg")) decreases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation")) - pmid:22299660 + pubmed:21427723 - act(p(FPLX:PPP2)) negativeCorrelation path(MESH:"Alzheimer Disease") + p(MGI:Mapt, var("p.Lys163Arg"), var("p.Lys280Arg"), var("p.Lys281Arg"), var("p.Lys369Arg")) decreases act(p(MGI:Mapt)) - pmid:22299660 + pubmed:21427723 - p(FPLX:PPP2) negativeCorrelation path(MESH:"Down Syndrome") + p(MGI:Mapt, var("p.Lys163Arg"), var("p.Lys280Arg"), var("p.Lys281Arg"), var("p.Lys369Arg")) negativeCorrelation bp(GO:"microtubule bundle formation") + + - pmid:23943618 + pubmed:25031639 - act(p(FPLX:PPP2)) positiveCorrelation complex(p(FPLX:PPP2), p(HGNC:MAPT)) + a(MESH:Microtubules) positiveCorrelation p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) - pmid:27068745 + pubmed:25031639 - act(p(FPLX:PPP2), ma(phos)) positiveCorrelation p(HGNC:UNC5B) + a(MESH:Microtubules) negativeCorrelation act(p(HGNC:HDAC6)) - pmid:27068745 + pubmed:25031639 - act(p(FPLX:PPP2), ma(phos)) decreases act(p(HGNC:DAPK1, pmod(Ph))) + a(MESH:Microtubules) negativeCorrelation path(DOID:"Alzheimer's disease") - pmid:23454242 + pubmed:25031639 - path(MESH:"Cell Transformation, Neoplastic") association p(FPLX:PPP2) + a(MESH:Microtubules) positiveCorrelation a(CHEBI:"epothilone D") - - - pmid:22299660 + pubmed:22372633 - p(FPLX:PPP2C) negativeCorrelation path(MESH:"Alzheimer Disease") + act(a(MESH:Microtubules)) association p(HGNC:TPPP) @@ -95204,23 +95970,12 @@

Statements

- - - - - - - - - - - - - - - - - + + + pubmed:29238289 + + a(MESH:Microtubules) association p(HGNC:MAPT) + @@ -95234,2613 +95989,2567 @@

Statements

- pmid:23454242 + pubmed:21427723 - p(HGNC:PPP2CA) association a(MESH:"Cell Membrane") + bp(GO:"microtubule bundle formation") positiveCorrelation act(p(MGI:Mapt)) - - - - - pmid:19277525 + pubmed:21427723 - p(HGNC:PPP2CA) increases complex(p(HGNC:PPP2CA), p(INTERPRO:"HEAT repeat")) + bp(GO:"microtubule bundle formation") negativeCorrelation p(MGI:Mapt, var("p.Lys163Arg"), var("p.Lys280Arg"), var("p.Lys281Arg"), var("p.Lys369Arg")) - pmid:19277525 + pubmed:21427723 - p(HGNC:PPP2CA) increases complex(GO:"protein phosphatase type 2A complex") + bp(GO:"microtubule bundle formation") negativeCorrelation p(MGI:Mapt, var("p.Lys280Arg")) - pmid:24653673 + pubmed:21427723 - p(HGNC:PPP2CA) association act(complex(GO:"protein phosphatase type 2A complex")) + p(MGI:Mapt, var("p.Lys280Arg")) decreases act(p(MGI:Mapt)) - - - - - - - - - pmid:24653673 + pubmed:21427723 - p(HGNC:PPP2CA) negativeCorrelation path(MESH:"Alzheimer Disease") + p(MGI:Mapt, var("p.Lys280Arg")) negativeCorrelation bp(GO:"microtubule bundle formation") - pmid:26631930 + pubmed:21427723 - act(p(HGNC:PPP2CA)) negativeCorrelation path(MESH:"Alzheimer Disease") + p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 280)) regulates act(p(MGI:Mapt)) - pmid:24653673 + pubmed:21427723 - deg(p(HGNC:PPP2CA)) positiveCorrelation p(HGNC:IGBP1, frag("?")) + p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 280)) positiveCorrelation bp(GO:aging) - pmid:24653673 + pubmed:21427723 - p(HGNC:PPP2CA) decreases p(HGNC:MAPT, pmod(Ph)) + p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 280)) positiveCorrelation path(CONSO:"4R tauopathy") - pmid:29191965 + pubmed:21427723 - p(HGNC:PPP2CA) directlyDecreases p(HGNC:MAPT, pmod(Ph)) + p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 280)) positiveCorrelation complex(p(CONSO:"3R tau"), p(CONSO:"4R tau")) - pmid:26631930 + pubmed:21427723 - p(HGNC:PPP2CA) directlyDecreases p(HGNC:MAPT, pmod(Ph)) + p(MGI:Mapt, var("p.Lys280del")) association path(DOID:"frontotemporal dementia") - pmid:26631930 + pubmed:21427723 - p(HGNC:PPP2CA) directlyDecreases p(HGNC:MAPT, pmod(Ph)) + p(MGI:Mapt, var("p.Lys280del")) association path(DOID:tauopathy) - - - pmid:29626319 + pubmed:21427723 - p(HGNC:PPP2CA) increases bp(GO:autophagy) + p(MGI:Mapt, var("p.Lys280del")) negativeCorrelation bp(GO:"microtubule polymerization") - pmid:10464280 + pubmed:21427723 - p(HGNC:PPP2CA) association complex(GO:microtubule) + p(MGI:Mapt, var("p.Lys280del")) increases p(CONSO:"paired helical filaments") - pmid:10464280 + pubmed:21427723 - p(HGNC:PPP2CA) increases complex(complex(GO:microtubule), p(HGNC:PPP2CA)) + p(MGI:Mapt, var("p.Lys280del")) association p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation")) - pmid:29228318 + pubmed:21427723 - act(p(HGNC:PPP2CA)) directlyDecreases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) + path(DOID:"frontotemporal dementia") association p(MGI:Mapt, var("p.Lys280del")) - pmid:19401603 + pubmed:29661268 - act(p(HGNC:PPP2CA)) directlyDecreases p(HGNC:MAPT, pmod(Ph, Thr, 231)) + path(DOID:"frontotemporal dementia") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 174)) - pmid:19401603 + pubmed:29661268 - act(p(HGNC:PPP2CA)) directlyDecreases p(HGNC:MAPT, pmod(Ph, Thr, 212)) + path(DOID:"frontotemporal dementia") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 274)) - pmid:23454242 + pubmed:29661268 - p(HGNC:PPP2CB) association a(MESH:Cytosol) + path(DOID:"frontotemporal dementia") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) - pmid:23454242 + pubmed:30108137 - p(HGNC:PPP2CB) association a(MESH:"Cell Nucleus") + path(DOID:"frontotemporal dementia") increases r(HGNC:TFEB) - - - - - - - pmid:24653673 + pubmed:30108137 - p(HGNC:PPP2CB) association act(complex(GO:"protein phosphatase type 2A complex")) + path(DOID:"frontotemporal dementia") increases r(HGNC:LAMP1) - pmid:24653673 + pubmed:30108137 - p(HGNC:PPP2CB) negativeCorrelation path(MESH:"Alzheimer Disease") + path(DOID:"frontotemporal dementia") increases p(HGNC:LAMP1) - pmid:24653673 + pubmed:30108137 - deg(p(HGNC:PPP2CB)) positiveCorrelation p(HGNC:IGBP1, frag("?")) + path(DOID:"frontotemporal dementia") increases p(HGNC:CTSD) - pmid:24653673 + pubmed:18305152 - p(HGNC:PPP2CB) decreases p(HGNC:MAPT, pmod(Ph)) + path(DOID:"frontotemporal dementia") association p(CONSO:"TDP-43 aggregates", loc(GO:cytoplasm)) - - - pmid:23454242 + pubmed:21427723 - a(MESH:"Cell Membrane") association p(HGNC:PPP2CA) + path(DOID:tauopathy) association p(MGI:Mapt, var("p.Lys280del")) - pmid:22299660 + pubmed:25031639 - a(MESH:"Cell Membrane") association p(FPLX:PPP2) + path(DOID:tauopathy) association bp(GO:"axonal transport") - pmid:21339331 + pubmed:25031639 - a(MESH:"Cell Membrane") association p(HGNC:ANXA2) + path(DOID:tauopathy) positiveCorrelation p(HGNC:HDAC6) - pmid:21339331 + pubmed:25031639 - a(MESH:"Cell Membrane") isA complex(a(MESH:"Cell Membrane"), p(HGNC:ANXA2), p(HGNC:MAPT)) + path(DOID:tauopathy) increases p(CONSO:"KXGS motif", pmod(go:0006468 ! "protein phosphorylation")) - pmid:23454242 + pubmed:25031639 - a(MESH:Cytosol) association p(HGNC:PPP2CB) + path(DOID:tauopathy) decreases p(CONSO:"KXGS motif", pmod(go:0006473 ! "protein acetylation")) - pmid:23454242 + pubmed:29661268 - a(MESH:Cytosol) association p(HGNC:PPP2R2A) + path(DOID:tauopathy) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) - pmid:23454242 + pubmed:29661268 - a(MESH:Cytosol) association p(HGNC:PPP2R2B) + path(DOID:tauopathy) negativeCorrelation p(HGNC:STUB1) - pmid:23454242 + pubmed:29661268 - a(MESH:Cytosol) association p(HGNC:PPP2R5A) + path(DOID:tauopathy) negativeCorrelation p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) - pmid:23454242 + pubmed:23516100 - a(MESH:Cytosol) association p(HGNC:PPP2R5B) + path(DOID:tauopathy) positiveCorrelation p(HGNC:MAPT, frag("?")) - pmid:23454242 + pubmed:23516100 - a(MESH:Cytosol) association p(HGNC:PPP2R5E) + path(DOID:tauopathy) increases p(HGNC:MAPT, frag("?_*")) - pmid:23454242 + pubmed:28148553 - a(MESH:Cytosol) association p(HGNC:PPP2R5D) + path(DOID:tauopathy) association a(PUBCHEM:354398) - pmid:22299660 + pubmed:28148553 - a(MESH:Cytosol) association p(FPLX:PPP2) + path(DOID:tauopathy) association p(MESH:"Neurofilament Proteins", pmod(go:0006468 ! "protein phosphorylation")) - pmid:23454242 + pubmed:30108137 - a(MESH:"Cell Nucleus") association p(HGNC:PPP2CB) + path(DOID:tauopathy) increases p(HGNC:TFEB) - pmid:23454242 + pubmed:30108137 - a(MESH:"Cell Nucleus") association p(HGNC:PPP2R5C) + path(DOID:tauopathy) increases act(p(HGNC:TFEB)) - pmid:23454242 + pubmed:30108137 - a(MESH:"Cell Nucleus") association p(HGNC:PPP2R5D) + path(DOID:tauopathy) increases p(HGNC:TFEB, loc(GO:nucleus)) - pmid:22299660 + pubmed:30108137 - a(MESH:"Cell Nucleus") association p(FPLX:PPP2) + path(DOID:tauopathy) increases p(HGNC:LAMP1) - pmid:19277525 + pubmed:30108137 - p(HGNC:PPP2R1A) association p(INTERPRO:"HEAT repeat") + path(DOID:tauopathy) increases p(HGNC:CTSD) - - - pmid:19277525 - - act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A)) - + + + - pmid:19277525 + pubmed:26751493 - act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) + p(CONSO:"paired helical filaments") association p(HGNC:MAPT, var("p.Glu391*")) - pmid:19277525 + pubmed:26751493 - act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + p(CONSO:"paired helical filaments") partOf a(GO:"neurofibrillary tangle") - pmid:19277525 + pubmed:17493042 - act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(HGNC:PPP2R3B)) + p(CONSO:"paired helical filaments") increases bp(GO:"neurofibrillary tangle assembly") + + - pmid:19277525 + pubmed:21427723 - act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(HGNC:PPP2R3A)) + p(MGI:Mapt, var("p.Pro301Ser")) increases p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) - pmid:19277525 + pubmed:28877763 - act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(HGNC:STRN3)) + p(MGI:Mapt, var("p.Pro301Ser")) increases p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) - pmid:19277525 + pubmed:28877763 - act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(HGNC:STRN)) + p(MGI:Mapt, var("p.Pro301Ser")) increases p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) - pmid:19277525 + pubmed:29540553 - act(p(HGNC:PPP2R1A)) increases act(p(HGNC:PPP2CA)) + p(MGI:Mapt, var("p.Pro301Ser")) causesNoChange p(MGI:Syp) - - - pmid:23454242 + pubmed:29540553 - p(HGNC:PPP2R2A) association a(MESH:Cytosol) + p(MGI:Mapt, var("p.Pro301Ser")) decreases path(MESH:"Neuronal Plasticity") + + - pmid:23454242 + pubmed:28877763 - p(HGNC:PPP2R2A) increases bp(GO:cytokinesis) + p(MGI:Mapt, var("p.Pro301Ser")) increases a(CONSO:"Tau aggregates") - pmid:23454242 + pubmed:30985105 - p(HGNC:PPP2R2A) association bp(GO:"cytoskeleton organization") + p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) negativeCorrelation p(MGI:Mapt, pmod(CONSO:O-GlcNAcylation)) - pmid:24653673 + pubmed:28877763 - p(HGNC:PPP2R2A) increases act(complex(GO:"protein phosphatase type 2A complex")) + p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) increases act(p(MGI:Syk)) - pmid:24653673 + pubmed:28877763 - p(HGNC:PPP2R2A) decreases p(HGNC:MAPT, pmod(Ph)) + p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) increases a(CONSO:"Tau aggregates") - pmid:24653673 + pubmed:26458742 - p(HGNC:PPP2R2A) increases complex(a(GO:"protein phosphatase type 2A complex"), a(GO:microtubule)) + p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) increases tloc(p(MGI:Mapt), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) - pmid:24653673 + pubmed:19491104 - p(HGNC:PPP2R2A) negativeCorrelation path(MESH:"Alzheimer Disease") + p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) association p(MGI:Mapk8ip1) - pmid:22299660 + pubmed:19491104 - p(HGNC:PPP2R2A) negativeCorrelation path(MESH:"Alzheimer Disease") + p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) negativeCorrelation act(p(MGI:Mapk8ip1)) - pmid:22299660 + pubmed:19491104 - p(HGNC:PPP2R2A) association a(MESH:Brain) + p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) negativeCorrelation act(p(MGI:Klc1)) - pmid:23454242 + pubmed:19491104 - p(HGNC:PPP2R2B) association a(MESH:Cytosol) + p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) negativeCorrelation complex(p(MGI:Klc1), p(MGI:Mapk8ip1)) + + - pmid:23454242 + pubmed:26400044 - p(HGNC:PPP2R2B) increases bp(GO:cytokinesis) + p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) increases complex(p(MGI:Dpysl2, pmod(go:0006468 ! "protein phosphorylation")), p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)), p(MGI:Wasf1, pmod(go:0006468 ! "protein phosphorylation"))) - pmid:23454242 + pubmed:25143394 - p(HGNC:PPP2R2B) association bp(GO:"cytoskeleton organization") + p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) negativeCorrelation p(MGI:Ppp1ca) - pmid:23454242 + pubmed:25143394 - p(HGNC:PPP2R2C) association a(MESH:Cytoskeleton) + p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) negativeCorrelation p(MGI:Ppp2ca) - pmid:23454242 + pubmed:25143394 - p(HGNC:PPP2R2C) increases bp(GO:cytokinesis) + p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) negativeCorrelation p(MGI:Ppp1cb) - pmid:23454242 + pubmed:21427723 - p(HGNC:PPP2R2C) association bp(GO:"cytoskeleton organization") + p(MGI:App, var("p.Val717Phe")) increases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 280)) - - - pmid:19277525 - - p(HGNC:PPP2R3A) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R3A)) - + - - - pmid:19277525 - - p(HGNC:PPP2R3A) directlyIncreases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R3A)) - + - - - pmid:19277525 - - p(HGNC:PPP2R3A) association p(INTERPRO:"EF-hand domain") - + + + + + + + - pmid:19277525 + pubmed:29221819 - p(HGNC:PPP2R3B) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R3B)) + p(MGI:App) positiveCorrelation p(MGI:Dyrk1a) - pmid:19277525 + pubmed:21427723 - p(HGNC:PPP2R3B) directlyIncreases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R3B)) + p(GO:"neurofibrillary tangle") increases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 280)) + + + + - pmid:19277525 + pubmed:23516100 - p(HGNC:PTPA) increases act(complex(GO:"protein phosphatase type 2A complex")) + p(GO:"neurofibrillary tangle") negativeCorrelation bp(GO:behavior) + + + + - pmid:24653673 + pubmed:21427723 - p(HGNC:PTPA) increases act(complex(GO:"protein phosphatase type 2A complex")) + path(CONSO:"Corticobasal Degeneration") increases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 280)) - pmid:19277525 + pubmed:30108137 - p(HGNC:PTPA) decreases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) + path(CONSO:"Corticobasal Degeneration") increases p(HGNC:TFEB) - pmid:19277525 + pubmed:27574109 - p(HGNC:PTPA) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) + path(CONSO:"Corticobasal Degeneration") association a(CONSO:"Tau oligomers") - pmid:24653673 + pubmed:27574109 - p(HGNC:PTPA) negativeCorrelation path(MESH:"Alzheimer Disease") + path(CONSO:"Corticobasal Degeneration") positiveCorrelation a(CONSO:"Tau oligomers") - pmid:24653673 + pubmed:27574109 - p(HGNC:PTPA) decreases p(FPLX:PPP2, pmod(Ph, Tyr, 307)) + path(CONSO:"Corticobasal Degeneration") positiveCorrelation a(CONSO:"Tau oligomers") - pmid:23454242 + pubmed:27574109 - p(HGNC:PPP2R5A) association a(MESH:Cytosol) + path(CONSO:"Corticobasal Degeneration") association p(CONSO:"phosphatase-activating domain") - - - pmid:23454242 + pubmed:27574109 - p(HGNC:PPP2R5B) association a(MESH:Cytosol) + path(CONSO:"Corticobasal Degeneration") positiveCorrelation p(CONSO:"phosphatase-activating domain") - pmid:21882945 + pubmed:27574109 - p(HGNC:PPP2R5B) decreases p(HGNC:MAPT, pmod(Ph)) + path(CONSO:"Corticobasal Degeneration") association p(HGNC:MAPT) - pmid:23454242 + pubmed:27574109 - p(HGNC:PPP2R5C) association a(MESH:"Cell Nucleus") + path(CONSO:"Corticobasal Degeneration") positiveCorrelation p(HGNC:MAPT) - pmid:23454242 + pubmed:27574109 - p(HGNC:PPP2R5D) association a(MESH:Cytosol) + path(CONSO:"Corticobasal Degeneration") positiveCorrelation p(HGNC:MAPT) - pmid:23454242 + pubmed:27574109 - p(HGNC:PPP2R5D) association a(MESH:"Cell Nucleus") + path(CONSO:"Corticobasal Degeneration") positiveCorrelation p(CONSO:"4R tau") - - - pmid:24653673 + pubmed:26751493 - p(HGNC:PPP2R5D) decreases p(HGNC:MAPT, pmod(Ph)) + path(CONSO:"Corticobasal Degeneration") positiveCorrelation p(CONSO:"4R tau") - pmid:23454242 + pubmed:26631930 - p(HGNC:PPP2R5E) association a(MESH:Cytosol) + path(CONSO:"Corticobasal Degeneration") positiveCorrelation p(CONSO:"4R tau") - pmid:23454242 + pubmed:27574109 - a(MESH:Cytoskeleton) association p(HGNC:PPP2R2C) + path(CONSO:"Corticobasal Degeneration") positiveCorrelation composite(p(CONSO:"phosphatase-activating domain"), p(HGNC:MAPT)) - pmid:22299660 + pubmed:26631930 - a(MESH:Cytoskeleton) association p(FPLX:PPP2) + path(CONSO:"Corticobasal Degeneration") isA path(MESH:Tauopathies) - - - - - pmid:23454242 + pubmed:22057784 - composite(a(CHEBI:"magnesium(2+)"), a(CHEBI:ATP)) increases act(p(HGNC:PPP2R3A)) + path(CONSO:"Corticobasal Degeneration") positiveCorrelation p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 197)) - pmid:24027553 + pubmed:17050703 - composite(a(CHEBI:"magnesium(2+)"), a(CHEBI:ATP)) increases act(p(HGNCGENEFAMILY:Proteasome)) + path(CONSO:"Corticobasal Degeneration") association p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) - - - - - pmid:23454242 + pubmed:21427723 - complex(p(FPLX:PPP2), p(HGNC:SGO1)) decreases p(FPLX:Cohesin, pmod(Ph)) + path(CONSO:"Corticobasal Degeneration") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) - pmid:23454242 + pubmed:21427723 - p(FPLX:Cohesin, pmod(Ph)) increases bp(GO:"spindle disassembly") + path(CONSO:"Corticobasal Degeneration") isA path(CONSO:"4R tauopathy") - - - pmid:23454242 + pubmed:21427723 - p(HGNC:SET) decreases act(p(FPLX:PPP2)) + path(DOID:"progressive supranuclear palsy") increases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 280)) - pmid:22299660 + pubmed:28148553 - p(HGNC:SET) decreases act(p(FPLX:PPP2)) + path(DOID:"progressive supranuclear palsy") increases p(HGNC:EIF2AK3, pmod(go:0006468 ! "protein phosphorylation")) - pmid:24653673 + pubmed:28148553 - p(HGNC:SET) decreases act(complex(GO:"protein phosphatase type 2A complex")) + path(DOID:"progressive supranuclear palsy") increases p(HGNC:EIF2AK3) - pmid:24653673 + pubmed:28148553 - p(HGNC:SET) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) + path(DOID:"progressive supranuclear palsy") decreases p(HGNC:EIF2A) - pmid:24653673 + pubmed:28148553 - p(HGNC:SET) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) + path(DOID:"progressive supranuclear palsy") decreases p(HGNC:EIF2A, pmod(go:0006468 ! "protein phosphorylation")) - pmid:24653673 + pubmed:28148553 - p(HGNC:SET) increases complex(p(HGNC:PPP2CA), p(HGNC:SET)) + path(DOID:"progressive supranuclear palsy") increases p(HGNC:NFE2L2) - pmid:24653673 + pubmed:28148553 - p(HGNC:SET) increases complex(p(HGNC:PPP2CB), p(HGNC:SET)) + path(DOID:"progressive supranuclear palsy") increases p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation")) - pmid:24653673 + pubmed:21427723 - p(HGNC:SET) positiveCorrelation path(MESH:"Alzheimer Disease") + path(DOID:"amyotrophic lateral sclerosis") increases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 280)) - pmid:22299660 + pubmed:22372633 - p(HGNC:SET) positiveCorrelation path(MESH:"Alzheimer Disease") + path(DOID:"amyotrophic lateral sclerosis") positiveCorrelation p(HGNC:HDAC6) - - - pmid:23454242 + pubmed:27181519 - a(CHEBI:"okadaic acid") increases path(MESH:Neoplasms) + path(DOID:"amyotrophic lateral sclerosis") negativeCorrelation act(p(HGNC:HDAC6)) - pmid:23454242 + pubmed:30935091 - a(CHEBI:"okadaic acid") decreases act(p(FPLX:PPP2C)) + path(DOID:"amyotrophic lateral sclerosis") association p(HGNC:FUS) - pmid:19277525 + pubmed:30935091 - a(CHEBI:"okadaic acid") decreases act(complex(GO:"protein phosphatase type 2A complex")) + path(DOID:"amyotrophic lateral sclerosis") association p(HGNC:TARDBP) - pmid:24653673 + pubmed:23384725 - a(CHEBI:"okadaic acid") decreases act(complex(GO:"protein phosphatase type 2A complex")) + path(DOID:"amyotrophic lateral sclerosis") association p(HGNC:TARDBP) - pmid:24653673 + pubmed:30515821 - a(CHEBI:"okadaic acid") decreases act(complex(GO:"protein phosphatase type 2A complex")) + path(DOID:"amyotrophic lateral sclerosis") negativeCorrelation path(MESH:"Mitochondrial Dynamics") - pmid:19277525 + pubmed:30515821 - a(CHEBI:"okadaic acid") decreases act(p(HGNC:PPP2CA)) + path(DOID:"amyotrophic lateral sclerosis") increases bp(GO:"mitochondrial fission") - pmid:19277525 + pubmed:30515821 - a(CHEBI:"okadaic acid") decreases act(p(HGNC:PPME1)) + path(DOID:"amyotrophic lateral sclerosis") increases a(CHEBI:"reactive oxygen species") - pmid:24653673 + pubmed:30515821 - a(CHEBI:"okadaic acid") increases complex(a(CHEBI:"okadaic acid"), p(HGNC:PPP2CA)) + path(DOID:"amyotrophic lateral sclerosis") increases act(p(HGNC:DNM1L)) - pmid:24653673 + pubmed:21861815 - a(CHEBI:"okadaic acid") increases complex(a(CHEBI:"okadaic acid"), p(HGNC:PPP2CB)) + path(DOID:"amyotrophic lateral sclerosis") negativeCorrelation act(p(HGNC:VEGFA)) - pmid:24653673 + pubmed:21861815 - a(CHEBI:"okadaic acid") decreases bp(GO:cognition) + path(DOID:"amyotrophic lateral sclerosis") negativeCorrelation act(p(NCIT:C13718)) - pmid:24653673 + pubmed:21861815 - a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Ph)) + path(DOID:"amyotrophic lateral sclerosis") decreases p(HGNC:EPO) - pmid:24653673 + pubmed:27181519 - a(CHEBI:"okadaic acid") increases bp(HBP:amyloidogenesis) + path(DOID:"amyotrophic lateral sclerosis") isA path(MESH:"Motor Neuron Disease") - pmid:24653673 + pubmed:27181519 - a(CHEBI:"okadaic acid") decreases a(GO:synapse) + path(DOID:"amyotrophic lateral sclerosis") positiveCorrelation bp(GO:"motor neuron apoptotic process") - pmid:24653673 + pubmed:27181519 - a(CHEBI:"okadaic acid") increases path(HBP:Neurodegeneration) + path(DOID:"amyotrophic lateral sclerosis") positiveCorrelation bp(GO:"muscle atrophy") - pmid:22299660 + pubmed:27181519 - a(CHEBI:"okadaic acid") decreases act(p(FPLX:PPP2)) + path(DOID:"amyotrophic lateral sclerosis") negativeCorrelation bp(CONSO:Proteostasis) - pmid:22299660 + pubmed:27181519 - a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Ph, Ser, 198)) + path(DOID:"amyotrophic lateral sclerosis") association g(HGNC:SOD1) - pmid:22299660 + pubmed:27181519 - a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Ph, Ser, 199)) + path(DOID:"amyotrophic lateral sclerosis") negativeCorrelation a(CHEBI:"all-trans-retinoic acid") - pmid:22299660 + pubmed:27181519 - a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) + path(DOID:"amyotrophic lateral sclerosis") negativeCorrelation bp(GO:autophagy) - pmid:22299660 + pubmed:27181519 - a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + path(DOID:"amyotrophic lateral sclerosis") negativeCorrelation bp(GO:autophagy) - pmid:22299660 + pubmed:27181519 - a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + path(DOID:"amyotrophic lateral sclerosis") positiveCorrelation complex(GO:"cytoplasmic stress granule", loc(MESH:"Motor Neurons")) - pmid:22299660 + pubmed:27181519 - a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Ph, Ser, 422)) + path(DOID:"amyotrophic lateral sclerosis") positiveCorrelation p(HGNC:TARDBP, var("?")) - pmid:22299660 + pubmed:27181519 - a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + path(DOID:"amyotrophic lateral sclerosis") positiveCorrelation p(HGNC:FUS, var("?")) - pmid:22299660 + pubmed:27181519 - a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + path(DOID:"amyotrophic lateral sclerosis") association p(HGNC:MATR3) - pmid:22299660 + pubmed:27181519 - a(CHEBI:"okadaic acid") decreases bp(GO:learning) + path(DOID:"amyotrophic lateral sclerosis") association p(HGNC:HNRNPA2B1) - pmid:22299660 + pubmed:27181519 - a(CHEBI:"okadaic acid") decreases bp(GO:memory) + path(DOID:"amyotrophic lateral sclerosis") association p(HGNC:HNRNPA1) - pmid:16464864 + pubmed:27181519 - a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Sumo, Lys, 340)) + path(DOID:"amyotrophic lateral sclerosis") association g(HGNC:C9orf72, var("?")) - pmid:23454242 + pubmed:27181519 - a(PUBCHEM:5311365) decreases act(p(FPLX:PPP2)) + path(DOID:"amyotrophic lateral sclerosis") association p(HGNC:OPTN) - pmid:24653673 + pubmed:27181519 - a(PUBCHEM:5311365) decreases act(complex(GO:"protein phosphatase type 2A complex")) + path(DOID:"amyotrophic lateral sclerosis") association p(HGNC:OPTN, var("p.Glu478Gly")) - pmid:24653673 + pubmed:27181519 - a(PUBCHEM:5311365) increases complex(a(PUBCHEM:5311365), p(HGNC:PPP2CA)) + path(DOID:"amyotrophic lateral sclerosis") association p(HGNC:TBK1) - pmid:24653673 + pubmed:27181519 - a(PUBCHEM:5311365) increases complex(a(PUBCHEM:5311365), p(HGNC:PPP2CB)) + path(DOID:"amyotrophic lateral sclerosis") association p(HGNC:UBQLN2, var("?")) - pmid:23454242 + pubmed:27181519 - a(CHEBI:microcystin) decreases act(p(FPLX:PPP2)) + path(DOID:"amyotrophic lateral sclerosis") association p(HGNC:OPTN, var("?")) - pmid:23454242 + pubmed:27181519 - a(CHEBI:cantharidin) decreases act(p(FPLX:PPP2)) + path(DOID:"amyotrophic lateral sclerosis") association p(HGNC:SQSTM1, var("?")) - pmid:23454242 + pubmed:28669544 - a(PUBCHEM:4162) decreases act(p(FPLX:PPP2)) + path(DOID:"amyotrophic lateral sclerosis") increases p(HGNC:TARDBP, pmod(CONSO:"protein aggregation"), pmod(go:0016567 ! "protein ubiquitination"), loc(MESH:"Inclusion Bodies")) - pmid:23454242 + pubmed:28669544 - a(PUBCHEM:6913994) decreases act(p(FPLX:PPP2)) + path(DOID:"amyotrophic lateral sclerosis") negativeCorrelation a(MESH:"Motor Cortex") - pmid:24653673 + pubmed:28669544 - a(PUBCHEM:6913994) decreases act(complex(GO:"protein phosphatase type 2A complex")) + path(DOID:"amyotrophic lateral sclerosis") increases p(HGNC:CD68) - pmid:24653673 + pubmed:21427723 - a(PUBCHEM:6913994) increases complex(a(PUBCHEM:6913994), p(HGNC:PPP2CA)) + path(CONSO:"4R tauopathy") association path(DOID:"Alzheimer's disease") - pmid:24653673 + pubmed:21427723 - a(PUBCHEM:6913994) increases complex(a(PUBCHEM:6913994), p(HGNC:PPP2CB)) + path(CONSO:"4R tauopathy") positiveCorrelation p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 280)) - pmid:23454242 + pubmed:21427723 - a(CHEBI:Tautomycin) decreases act(p(FPLX:PPP2)) + path(CONSO:"4R tauopathy") association p(CONSO:"4R tau") - pmid:23454242 + pubmed:21427723 - a(PUBCHEM:71361092) increases path(MESH:Neoplasms) + complex(p(CONSO:"3R tau"), p(CONSO:"4R tau")) association path(DOID:"Alzheimer's disease") - pmid:23454242 + pubmed:21427723 - a(PUBCHEM:71361092) decreases act(p(FPLX:PPP2)) + complex(p(CONSO:"3R tau"), p(CONSO:"4R tau")) positiveCorrelation p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 280)) + + - pmid:23454242 + pubmed:21427723 - p(HGNC:CIP2A) decreases act(p(FPLX:PPP2C)) + p(CONSO:"3R tau") association path(DOID:"Niemann-Pick disease") - pmid:23454242 + pubmed:21427723 - a(CHEBI:bortezomib) decreases p(HGNC:CIP2A) + p(CONSO:"3R tau") causesNoChange p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 280)) - pmid:23454242 + pubmed:12428809 - a(CHEBI:bortezomib) increases act(p(FPLX:PPP2C)) + p(CONSO:"3R tau") increases a(CONSO:"straight filaments") - pmid:23454242 + pubmed:28148553 - p(FPLX:PPP2, pmod(Me)) association act(p(FPLX:PPP2)) + p(CONSO:"3R tau") decreases p(HGNC:EIF2A, pmod(go:0006468 ! "protein phosphorylation")) + + + + - pmid:19277525 + pubmed:28148553 - p(FPLX:PPP2, pmod(Me)) regulates bp(GO:"cell cycle") + p(CONSO:"3R tau") causesNoChange a(CONSO:"Tau antibody, MC1") - pmid:24653673 + pubmed:27574109 - p(FPLX:PPP2, pmod(Me)) positiveCorrelation complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) + p(CONSO:"3R tau") positiveCorrelation path(MESH:"Protein Aggregation, Pathological") - pmid:24653673 + pubmed:27574109 - p(FPLX:PPP2, pmod(Me)) association complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) + p(CONSO:"3R tau") positiveCorrelation path(MESH:"Protein Aggregation, Pathological") - pmid:24653673 + pubmed:27574109 - p(FPLX:PPP2, pmod(Me)) positiveCorrelation complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) + p(CONSO:"3R tau") positiveCorrelation bp(GO:"positive regulation of protein oligomerization") - pmid:24653673 + pubmed:27574109 - p(FPLX:PPP2, pmod(Me)) association complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) + p(CONSO:"3R tau") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:24653673 + pubmed:26631930 - p(FPLX:PPP2, pmod(Me)) negativeCorrelation path(MESH:"Alzheimer Disease") + p(CONSO:"3R tau") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:24653673 + pubmed:27574109 - p(FPLX:PPP2, pmod(Me)) negativeCorrelation path(MESH:"Alzheimer Disease") + p(CONSO:"3R tau") positiveCorrelation path(MESH:"Pick Disease of the Brain") - pmid:24653673 + pubmed:26655600 - p(FPLX:PPP2, pmod(Me)) negativeCorrelation path(MESH:"Alzheimer Disease") + p(CONSO:"3R tau", loc(GO:"Pick body")) positiveCorrelation path(MESH:"Pick Disease of the Brain") - pmid:24653673 + pubmed:26751493 - p(FPLX:PPP2, pmod(Me)) association bp(GO:"one-carbon metabolic process") + p(CONSO:"3R tau") positiveCorrelation path(MESH:"Niemann-Pick Diseases") - pmid:24653673 + pubmed:26631930 - p(FPLX:PPP2, pmod(Me)) negativeCorrelation a(CHEBI:homocysteine) + p(CONSO:"3R tau") positiveCorrelation path(MESH:"Niemann-Pick Diseases") + + - pmid:24653673 + pubmed:23407988 - p(FPLX:PPP2, pmod(Me)) negativeCorrelation p(HGNC:MAPT, pmod(Ph)) + p(CONSO:"3R tau") isA p(HGNC:MAPT) - pmid:24653673 + pubmed:23407988 - p(FPLX:PPP2, pmod(Me)) negativeCorrelation p(HGNC:APP, pmod(Ph)) + p(CONSO:"3R tau") partOf complex(GO:"neurofibrillary tangle") - pmid:24653673 + pubmed:23407988 - p(FPLX:PPP2, pmod(Me)) regulates bp(HBP:"APP processing") + p(CONSO:"3R tau") partOf a(CONSO:"ghost tangles") - pmid:24653673 + pubmed:23407988 - p(FPLX:PPP2, pmod(Me)) regulates bp(MESH:"Neuronal Outgrowth") + p(CONSO:"3R tau") partOf a(CONSO:"Brodmann (1909) area 36") - pmid:24653673 + pubmed:23407988 - p(FPLX:PPP2, pmod(Me)) regulates p(HGNC:MAPT) + p(CONSO:"3R tau") partOf a(CONSO:"CA1 field of hippocampus") - pmid:23454242 + pubmed:23407988 - p(FPLX:PPP2, pmod(Ph)) association act(p(FPLX:PPP2)) + p(CONSO:"3R tau") partOf a(CONSO:"CA2 field of hippocampus") - pmid:23454242 + pubmed:23407988 - p(FPLX:PPP2, pmod(Ph, Tyr, 307)) decreases act(p(FPLX:PPP2)) + p(CONSO:"3R tau") partOf a(CONSO:"CA3 field of hippocampus") - pmid:24653673 + pubmed:23407988 - p(FPLX:PPP2, pmod(Ph, Tyr, 307)) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) + p(CONSO:"3R tau") partOf a(CONSO:"CA4 field of hippocampus") - pmid:24653673 + pubmed:23407988 - p(FPLX:PPP2, pmod(Ph, Tyr, 307)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + p(CONSO:"3R tau") partOf complex(GO:dendrite) - pmid:23454242 + pubmed:23407988 - p(HGNC:LCMT1) increases p(FPLX:PPP2, pmod(Me, Leu, 309)) + p(CONSO:"3R tau") partOf a(MESH:Neuropil) - pmid:19277525 + pubmed:23407988 - p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) + p(CONSO:"3R tau") partOf complex(GO:"neuronal cell body") - pmid:19277525 + pubmed:26655600 - p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) + p(CONSO:"3R tau") causesNoChange a(CONSO:"Tau aggregates") - pmid:24653673 + pubmed:28775333 - p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) + p(CONSO:"3R tau") positiveCorrelation p(MGI:Dyrk1a) + + + + + + + + + + + + - pmid:24653673 + pubmed:12428809 - p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) + p(CONSO:"4R tau") increases path(MESH:"Wallerian Degeneration") - pmid:24653673 + pubmed:12428809 - p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) + p(CONSO:"4R tau") increases path(MESH:"Muscular Atrophy") - pmid:24653673 + pubmed:12428809 - p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) + p(CONSO:"4R tau") increases path(HP:Neurodegeneration) - pmid:23943618 + pubmed:12428809 - p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) + p(CONSO:"4R tau") positiveCorrelation path(MESH:"Frontotemporal Dementia") - pmid:29281045 + pubmed:26751493 - p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) + p(CONSO:"4R tau") positiveCorrelation path(MESH:"Frontotemporal Dementia") - pmid:19277525 + pubmed:12428809 - act(p(HGNC:LCMT1)) negativeCorrelation act(p(HGNC:PPME1)) + p(CONSO:"4R tau") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:19277525 + pubmed:27574109 - p(HGNC:LCMT1) causesNoChange act(complex(GO:"protein phosphatase type 2A complex")) + p(CONSO:"4R tau") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:24653673 + pubmed:26631930 - p(HGNC:LCMT1) increases p(HGNC:PPP2CB, pmod(Me, Leu, 309)) + p(CONSO:"4R tau") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:24653673 + pubmed:28148553 - p(HGNC:LCMT1) increases p(HGNC:PPP2CB, pmod(Me, Leu, 309)) + p(CONSO:"4R tau") decreases p(HGNC:EIF2A, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + - pmid:24653673 + pubmed:28148553 - p(HGNC:LCMT1) increases p(HGNC:PPP2CB, pmod(Me, Leu, 309)) + p(CONSO:"4R tau") causesNoChange a(CONSO:"Tau antibody, MC1") - pmid:24653673 + pubmed:27574109 - p(HGNC:LCMT1) increases p(HGNC:PPP2CB, pmod(Me, Leu, 309)) + p(CONSO:"4R tau") positiveCorrelation path(MESH:"Protein Aggregation, Pathological") - pmid:24653673 + pubmed:27574109 - p(HGNC:LCMT1) regulates complex(a(GO:"protein phosphatase type 2A complex"), a(MESH:"Membrane Microdomains")) + p(CONSO:"4R tau") positiveCorrelation path(MESH:"Protein Aggregation, Pathological") - pmid:24653673 + pubmed:27574109 - p(HGNC:LCMT1) increases p(FPLX:PPP2, pmod(Me)) + p(CONSO:"4R tau") positiveCorrelation bp(GO:"positive regulation of protein oligomerization") - pmid:23454242 + pubmed:27574109 - p(FPLX:PPP2, pmod(Me, Leu, 309)) increases act(p(FPLX:PPP2)) + p(CONSO:"4R tau") positiveCorrelation path(MESH:"Pick Disease of the Brain") - pmid:23454242 + pubmed:27574109 - p(FPLX:AKT, pmod(Ph, Thr, 308)) increases act(p(FPLX:AKT)) + p(CONSO:"4R tau") positiveCorrelation path(CONSO:"Corticobasal Degeneration") - pmid:23454242 + pubmed:26751493 - p(HGNC:CTNNB1, pmod(Ph)) increases bp(GO:"Wnt signaling pathway") + p(CONSO:"4R tau") positiveCorrelation path(CONSO:"Corticobasal Degeneration") - pmid:23454242 + pubmed:26631930 - p(HGNC:BAD, pmod(Ph)) decreases bp(GO:"apoptotic process") + p(CONSO:"4R tau") positiveCorrelation path(CONSO:"Corticobasal Degeneration") + + + + - pmid:23454242 + pubmed:26751493 - p(HGNC:BCL2, pmod(Ph)) decreases bp(GO:"apoptotic process") + p(CONSO:"4R tau") positiveCorrelation path(CONSO:"Argyrophilic Grain Disease") - pmid:21722302 + pubmed:26751493 - p(HGNC:BCL2, pmod(Ph)) decreases composite(a(MESH:"Beclin-1"), p(HGNC:BCL2)) + p(CONSO:"4R tau") positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") - pmid:23528736 + pubmed:26631930 - p(HGNC:BCL2, pmod(Ph)) increases bp(GO:autophagy) + p(CONSO:"4R tau") positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") + + - pmid:19277525 + pubmed:23407988 - complex(GO:"protein phosphatase type 2A complex") regulates bp(GO:"cell cycle") + p(CONSO:"4R tau") isA p(HGNC:MAPT) - pmid:19277525 + pubmed:23407988 - complex(GO:"protein phosphatase type 2A complex") regulates bp(GO:"cell population proliferation") + p(CONSO:"4R tau") partOf a(CONSO:pretangles) - pmid:19277525 + pubmed:23407988 - complex(GO:"protein phosphatase type 2A complex") regulates bp(GO:"cell death") + p(CONSO:"4R tau") partOf complex(GO:"neurofibrillary tangle") - pmid:19277525 + pubmed:23407988 - complex(GO:"protein phosphatase type 2A complex") regulates act(a(GO:cytoskeleton)) + p(CONSO:"4R tau") positiveCorrelation a(CONSO:"CA4 field of hippocampus") - pmid:19277525 + pubmed:23407988 - complex(GO:"protein phosphatase type 2A complex") regulates bp(GO:"cell motility") + p(CONSO:"4R tau") positiveCorrelation a(CONSO:"CA3 field of hippocampus") - pmid:19277525 + pubmed:23407988 - complex(GO:"protein phosphatase type 2A complex") regulates bp(GO:"signal transduction") + p(CONSO:"4R tau") positiveCorrelation a(CONSO:"CA2 field of hippocampus") - - - - - pmid:24653673 + pubmed:23407988 - act(complex(GO:"protein phosphatase type 2A complex")) association p(HGNC:PPP2CA) + p(CONSO:"4R tau") positiveCorrelation a(CONSO:"CA1 field of hippocampus") - pmid:19277525 + pubmed:23407988 - complex(GO:"protein phosphatase type 2A complex") increases bp(GO:"protein dephosphorylation") + p(CONSO:"4R tau") positiveCorrelation a(CONSO:"Brodmann (1909) area 36") - pmid:19277525 + pubmed:23407988 - complex(GO:"protein phosphatase type 2A complex") decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + p(CONSO:"4R tau") partOf complex(GO:"neuronal cell body") - pmid:19277525 + pubmed:23407988 - act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation composite(p(HGNC:PPME1), p(HGNC:PPP2CA), p(HGNC:PPP2R1A)) + p(CONSO:"4R tau") partOf complex(GO:dendrite) - pmid:24653673 + pubmed:23407988 - complex(GO:"protein phosphatase type 2A complex") decreases p(HGNC:MAPT, pmod(Ph)) + p(CONSO:"4R tau") partOf a(MESH:Neuropil) - pmid:24653673 + pubmed:28775333 - act(complex(GO:"protein phosphatase type 2A complex")) increases p(HGNC:MAPT, pmod(Ph)) + p(CONSO:"4R tau") negativeCorrelation p(MGI:Dyrk1a) - pmid:24653673 + pubmed:21427723 - act(complex(GO:"protein phosphatase type 2A complex")) decreases p(HGNC:MAPT, pmod(Ph)) + p(CONSO:"4R tau") association path(CONSO:"4R tauopathy") - pmid:24653673 + pubmed:27574109 - complex(GO:"protein phosphatase type 2A complex") increases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:GSK3B)) + p(CONSO:"4R tau") positiveCorrelation p(CONSO:"phosphatase-activating domain") - pmid:24653673 + pubmed:21427723 - complex(GO:"protein phosphatase type 2A complex") increases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:CDK5)) + path(DOID:"Niemann-Pick disease") association p(CONSO:"3R tau") - pmid:24653673 + pubmed:29661268 - complex(GO:"protein phosphatase type 2A complex") increases complex(a(GO:"protein phosphatase type 2A complex"), a(MESH:"Receptors, N-Methyl-D-Aspartate")) + path(DOID:"Niemann-Pick disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 174)) - pmid:24653673 + pubmed:29661268 - complex(GO:"protein phosphatase type 2A complex") increases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:GRM5)) + path(DOID:"Niemann-Pick disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 274)) - pmid:24653673 + pubmed:29661268 - act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation p(HGNC:PPME1) + path(DOID:"Niemann-Pick disease") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) - pmid:24653673 + pubmed:23516100 - act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation path(MESH:"Alzheimer Disease") + path(DOID:"Niemann-Pick disease") increases p(HGNC:MAPT, frag("1_421")) - pmid:24653673 + pubmed:23516100 - complex(GO:"protein phosphatase type 2A complex") positiveCorrelation path(MESH:"Alzheimer Disease") + path(DOID:"Niemann-Pick disease") increases p(HGNC:TARDBP, frag("?")) - pmid:24653673 + pubmed:25031639 - act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAPT, frag("?"), pmod(go:0006473 ! "protein acetylation", Lys, 18)) increases p(HGNC:MAPT, frag("?"), pmod(CONSO:"protein aggregates"), pmod(go:0006473 ! "protein acetylation", Lys, 18)) - pmid:24653673 + pubmed:29844403 - act(complex(GO:"protein phosphatase type 2A complex")) association p(HGNC:PPP2CB) + p(MESH:"Neurofibrillary Tangles") increases path(HP:"Abnormal synaptic transmission") - pmid:24653673 + pubmed:31248781 - act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation p(HGNC:ANP32A) + p(MESH:"Neurofibrillary Tangles") association path(CONSO:Neurodegeneration) - pmid:24653673 + pubmed:25031639 - act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation p(HGNC:SET) + bp(GO:"axonal transport") negativeCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:24653673 + pubmed:29844403 - act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation p(HGNC:SET) + bp(GO:"axonal transport") negativeCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:24653673 + pubmed:25031639 - act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation p(HGNC:SET, frag("?")) + bp(GO:"axonal transport") negativeCorrelation p(CONSO:"Tau aggregates") - pmid:24653673 + pubmed:25031639 - act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation p(FPLX:PPP2, pmod(Ph, Tyr, 307)) + bp(GO:"axonal transport") negativeCorrelation path(DOID:"Alzheimer's disease") - pmid:24653673 + pubmed:25031639 - act(complex(GO:"protein phosphatase type 2A complex")) decreases bp(GO:"neuron death") + bp(GO:"axonal transport") association path(DOID:tauopathy) - pmid:24653673 + pubmed:22372633 - act(complex(GO:"protein phosphatase type 2A complex")) increases act(p(HGNC:GSK3B)) + bp(GO:"axonal transport") negativeCorrelation p(HGNC:HDAC6) - pmid:24653673 + pubmed:22372633 - act(complex(GO:"protein phosphatase type 2A complex")) increases act(p(HGNC:CDK5)) + bp(GO:"axonal transport") negativeCorrelation p(HGNC:HDAC6) - pmid:24653673 + pubmed:30935091 - act(complex(GO:"protein phosphatase type 2A complex")) increases act(p(FPLX:ERK)) + bp(GO:"axonal transport") positiveCorrelation a(PUBCHEM:57381425) - pmid:24653673 + pubmed:30935091 - act(complex(GO:"protein phosphatase type 2A complex")) increases act(p(FPLX:JNK)) + bp(GO:"axonal transport") positiveCorrelation a(PUBCHEM:57381425) - pmid:10464280 + pubmed:30935091 - act(complex(GO:"protein phosphatase type 2A complex")) association p(HBP:"microtubule-binding region") + bp(GO:"axonal transport") positiveCorrelation a(PUBCHEM:57382288) - pmid:10464280 + pubmed:30935091 - act(complex(GO:"protein phosphatase type 2A complex")) increases rxn(reactants(p(HGNC:MAPT, pmod(Ph))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT))) + bp(GO:"axonal transport") negativeCorrelation path(DOID:"Charcot-Marie-Tooth disease") - pmid:19277525 + pubmed:30935091 - p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + bp(GO:"axonal transport") negativeCorrelation p(HGNC:GARS, var("?")) - pmid:19277525 + pubmed:30935091 - p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") directlyIncreases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + bp(GO:"axonal transport") positiveCorrelation a(PUBCHEM:49850262) - pmid:19277525 + pubmed:30935091 - p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + bp(GO:"axonal transport") positiveCorrelation a(PUBCHEM:49850262) - pmid:19277525 + pubmed:30935091 - p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") association p(INTERPRO:"WD40 repeat") + bp(GO:"axonal transport") negativeCorrelation p(HGNC:FUS, var("?")) - pmid:19277525 + pubmed:30515821 - p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases bp(GO:"protein dephosphorylation") + bp(GO:"axonal transport") positiveCorrelation path(MESH:"Mitochondrial Dynamics") - pmid:19277525 + pubmed:30515821 - p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases complex(p(HGNC:PPP2CA), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + bp(GO:"axonal transport") negativeCorrelation composite(a(CHEBI:amyloid-beta), p(HGNC:DNM1)) - pmid:19277525 + pubmed:30515821 - p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases complex(p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + bp(GO:"axonal transport") negativeCorrelation composite(p(HGNC:DNM1), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) - pmid:19277525 + pubmed:30515821 - p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + bp(GO:"axonal transport") negativeCorrelation complex(p(HGNC:DNM1L), p(HGNC:HTT, pmod(CONSO:"CAG repeats"))) - - - - - - - pmid:19277525 + pubmed:30515821 - complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) decreases p(HGNC:MAPT, pmod(Ph)) + bp(GO:"axonal transport") positiveCorrelation complex(p(HGNC:DNM1L, var("p.Lys38Ala")), p(HGNC:HTT, pmod(CONSO:"CAG repeats"))) - pmid:19277525 + pubmed:30515821 - p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) + bp(GO:"axonal transport") negativeCorrelation act(p(HGNC:DNM1L), ma(GO:"GTPase activity")) - pmid:19277525 + pubmed:12428809 - p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") directlyIncreases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) + bp(GO:"axonal transport") association p(HGNC:MAPT) - pmid:19277525 + pubmed:12428809 - p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") association p(INTERPRO:"HEAT repeat") + bp(GO:"axonal transport") association p(HGNC:APP) - pmid:19277525 + pubmed:12428809 - p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") regulates complex(p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) + bp(GO:"axonal transport") negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:19277525 + pubmed:22908190 - p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") increases complex(p(HGNC:PPP2CA), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) + bp(GO:"axonal transport") negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:24653673 + pubmed:12428809 - p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") increases tloc(complex(GO:"protein phosphatase type 2A complex"), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) + bp(GO:"axonal transport") association a(CHEBI:amyloid-beta) - pmid:24653673 + pubmed:12428809 - p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") increases tloc(complex(GO:"protein phosphatase type 2A complex"), fromLoc(GO:cytoplasm), toLoc(GO:centrosome)) + bp(GO:"axonal transport") association p(HGNC:GSK3B) - - - - - - - pmid:19277525 + pubmed:21722302 - complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:SGO1), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) + bp(GO:"axonal transport") association bp(GO:"motor neuron apoptotic process") - pmid:19277525 + pubmed:26631930 - complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) decreases p(HGNC:MAPT, pmod(Ph)) + bp(GO:"axonal transport") decreases path(CONSO:Neurodegeneration) - - - - - - - - - - - - - pmid:19277525 + pubmed:21734277 - p(HGNC:STRN3) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:STRN3)) + bp(GO:"axonal transport") negativeCorrelation p(CONSO:"phosphatase-activating domain") - pmid:19277525 + pubmed:25031639 - p(HGNC:STRN3) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:STRN3)) + bp(GO:"synaptic signaling") negativeCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - - - - - - - pmid:19277525 + pubmed:25031639 - p(HGNC:STRN) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:STRN)) + bp(GO:"synaptic signaling") negativeCorrelation p(CONSO:"Tau aggregates") - pmid:19277525 + pubmed:29428175 - p(HGNC:STRN) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:STRN)) + bp(GO:"synaptic signaling") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - - - - - - - pmid:19277525 + pubmed:23384725 - p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + bp(GO:"synaptic signaling") association p(HGNC:TARDBP) - pmid:19277525 + pubmed:30988501 - p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) + bp(GO:"synaptic signaling") association a(MESH:Microglia) - pmid:19277525 + pubmed:25031639 - p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R3B)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) positiveCorrelation path(DOID:"Alzheimer's disease") - pmid:19277525 + pubmed:29661268 - p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R3A)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) positiveCorrelation path(DOID:"Alzheimer's disease") - pmid:19277525 + pubmed:29661268 - p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:STRN3)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) positiveCorrelation path(DOID:"frontotemporal dementia") - pmid:19277525 + pubmed:29661268 - p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:STRN)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) positiveCorrelation path(DOID:"Niemann-Pick disease") - pmid:19277525 + pubmed:29661268 - p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases act(p(HGNC:PPP2CA)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) decreases p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination", Lys, 280)) - pmid:24653673 + pubmed:29661268 - p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases complex(GO:"protein phosphatase type 2A complex") + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) positiveCorrelation bp(GO:"microtubule severing") - pmid:24653673 + pubmed:29661268 - p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases act(complex(GO:"protein phosphatase type 2A complex")) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280), loc(CONSO:"microtubule-binding region")) increases bp(GO:"microtubule severing") - pmid:24653673 + pubmed:29661268 - p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2CB), p(HGNC:PPP2R2A)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) negativeCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:23943618 + pubmed:29661268 - p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases act(p(FPLX:PPP2)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) increases p(CONSO:"paired helical filaments") - pmid:19277525 + pubmed:29661268 - p(HGNC:PPP2CA, pmod(Me)) decreases complex(p(HGNC:IGBP1), p(HGNC:PPP2CA)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280), loc(CONSO:"microtubule-binding region")) increases p(CONSO:"Tau fibrils") - pmid:19277525 + pubmed:26631930 - p(HGNC:PPP2CA, pmod(Me)) causesNoChange complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) decreases deg(p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280))) - pmid:19277525 + pubmed:26631930 - p(HGNC:PPP2CA, pmod(Me)) causesNoChange complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:24653673 + pubmed:29276758 - p(HGNC:PPP2CA, pmod(Me)) increases act(complex(GO:"protein phosphatase type 2A complex")) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:29228318 + pubmed:21427723 - p(HGNC:PPP2CA, pmod(Me)) decreases act(p(HGNC:PPP2CA)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:29228318 + pubmed:26631930 - p(HGNC:PPP2CA, pmod(Me)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2CB)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) positiveCorrelation path(MESH:"Niemann-Pick Diseases") - - - - - pmid:24653673 + pubmed:26631930 - complex(p(HGNC:IGBP1), p(HGNC:PPP2CA)) regulates complex(GO:"protein phosphatase type 2A complex") + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) positiveCorrelation path(MESH:"Frontotemporal Dementia") - - - pmid:19277525 + pubmed:26631930 - p(HGNC:PPME1) decreases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") - pmid:19277525 + pubmed:29276758 - p(HGNC:PPME1) decreases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) decreases a(MESH:Neurons) - pmid:19277525 + pubmed:29276758 - p(HGNC:PPME1) decreases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) positiveCorrelation path(MESH:"Chronic Traumatic Encephalopathy") - pmid:24653673 + pubmed:26940749 - act(p(HGNC:PPME1)) decreases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) - pmid:29281045 + pubmed:26940749 - p(HGNC:PPME1) decreases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) increases path(CONSO:Neurodegeneration) - pmid:19277525 + pubmed:26192747 - act(p(HGNC:PPME1)) negativeCorrelation act(p(HGNC:LCMT1)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) isA p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) - pmid:19277525 + pubmed:26192747 - p(HGNC:PPME1) increases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) partOf p(CONSO:"microtubule-binding region") - pmid:19277525 + pubmed:21427723 - p(HGNC:PPME1) directlyIncreases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) positiveCorrelation path(CONSO:"Corticobasal Degeneration") + + - pmid:19277525 + pubmed:25031639 - p(HGNC:PPME1) decreases act(complex(GO:"protein phosphatase type 2A complex")) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) decreases complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)), p(HGNC:STUB1)) - pmid:24653673 + pubmed:29215007 - p(HGNC:PPME1) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) - pmid:24653673 + pubmed:29215007 - p(HGNC:PPME1) increases complex(p(HGNC:PPME1), p(HGNC:PPP2CA)) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) decreases bp(GO:"actin filament bundle assembly") - pmid:24653673 + pubmed:26751493 - p(HGNC:PPME1) increases complex(p(HGNC:PPME1), p(HGNC:PPP2CB)) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:22299660 + pubmed:26631930 - p(HGNC:PPME1) decreases p(FPLX:PPP2C, pmod(Me)) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) decreases complex(p(HGNC:MAPT), p(HGNC:STUB1)) - pmid:19277525 + pubmed:26631930 - p(INTERPRO:"HEAT repeat") association p(HGNC:PPP2R1A) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) decreases deg(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262))) - - - - - pmid:19277525 + pubmed:17493042 - p(INTERPRO:"HEAT repeat") association p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) - pmid:19277525 + pubmed:17493042 - p(UNIPROT:P03081) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(UNIPROT:P03081)) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) decreases p(CONSO:"Tau aggregates") - - - + + + pubmed:17493042 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) decreases bp(GO:"neurofibrillary tangle assembly") + - + + + pubmed:21367866 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) positiveCorrelation p(HGNC:CDC37) + - pmid:19277525 + pubmed:22156579 - p(INTERPRO:"HEAT repeat", var("p.Arg418Trp")) decreases complex(p(HGNC:PPP2CA), p(INTERPRO:"HEAT repeat")) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) partOf p(CONSO:"Tau epitope, 12E8") - pmid:19277525 + pubmed:22833681 - p(INTERPRO:"HEAT repeat", var("p.Val545Ala")) decreases complex(p(HGNC:PPP2CA), p(INTERPRO:"HEAT repeat")) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) positiveCorrelation p(HGNC:MAPT, pmod(CONSO:O-GlcNAcylation)) - pmid:19277525 + pubmed:25031639 - a(CHEBI:"microcystin-LR") decreases act(complex(GO:"protein phosphatase type 2A complex")) + p(CONSO:"Tau epitope, 12E8") partOf p(CONSO:"KXGS motif") - pmid:19277525 + pubmed:25031639 - a(CHEBI:"microcystin-LR") decreases act(p(HGNC:PPME1)) + p(CONSO:"Tau epitope, 12E8") partOf p(CONSO:"KXGS motif") - pmid:29228318 + pubmed:22156579 - a(CHEBI:"microcystin-LR") decreases p(HGNC:PPP2CA, pmod(Me)) + p(CONSO:"Tau epitope, 12E8") positiveCorrelation p(CONSO:"Tau epitope, PHF1") @@ -97851,469 +98560,519 @@

Statements

- - - pmid:19277525 + pubmed:25031639 - complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:SGO1), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) increases bp(GO:"cell cycle") + p(CONSO:"KXGS motif", pmod(go:0006468 ! "protein phosphorylation")) increases path(MESH:Tauopathies) - - - - - pmid:19277525 + pubmed:25031639 - p(INTERPRO:"WD40 repeat") association p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") + p(CONSO:"KXGS motif", pmod(go:0006468 ! "protein phosphorylation")) increases p(MESH:"Neurofibrillary Tangles") - pmid:19277525 + pubmed:25031639 - p(INTERPRO:"EF-hand domain") association p(HGNC:PPP2R3A) + p(CONSO:"KXGS motif", pmod(go:0006468 ! "protein phosphorylation")) decreases complex(p(HGNC:MAPT), p(HGNC:STUB1)) - - - - - - - - - - - - - + + + pubmed:25031639 + + p(CONSO:"KXGS motif", pmod(go:0006468 ! "protein phosphorylation")) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:"Heat shock 70kDa proteins")) + - + + + pubmed:25031639 + + p(CONSO:"KXGS motif", pmod(go:0006468 ! "protein phosphorylation")) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:"Heat shock 90kDa proteins")) + - pmid:19277525 + pubmed:25031639 - complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A)) decreases p(HGNC:MAPT, pmod(Ph)) + p(CONSO:"KXGS motif", pmod(go:0006468 ! "protein phosphorylation")) increases p(CONSO:"Tau aggregates") - pmid:19277525 + pubmed:25031639 - complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + p(CONSO:"KXGS motif", pmod(go:0006468 ! "protein phosphorylation")) increases p(CONSO:"Tau aggregates", loc(MESH:"Neurofibrillary Tangles")) - + + + pubmed:25031639 + + p(CONSO:"KXGS motif", pmod(go:0006468 ! "protein phosphorylation")) decreases act(p(HGNC:MAPT), ma(GO:"microtubule binding")) + - + + + pubmed:25031639 + + p(CONSO:"KXGS motif", pmod(go:0006468 ! "protein phosphorylation")) decreases p(CONSO:"KXGS motif", pmod(go:0006473 ! "protein acetylation")) + - + + + pubmed:25031639 + + p(CONSO:"KXGS motif", pmod(go:0006468 ! "protein phosphorylation")) increases deg(complex(a(MESH:Microtubules), p(HGNC:MAPT))) + - + + + pubmed:25031639 + + p(CONSO:"KXGS motif", pmod(go:0006468 ! "protein phosphorylation")) association p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) + - pmid:19277525 + pubmed:25031639 - p(HGNC:PPP2CA, var("?")) causesNoChange complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + p(CONSO:"KXGS motif", pmod(go:0006468 ! "protein phosphorylation")) association p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) - pmid:19277525 + pubmed:25031639 - p(HGNC:PPP2CA, var("?")) causesNoChange complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) + p(CONSO:"KXGS motif", pmod(go:0006468 ! "protein phosphorylation")) increases path(DOID:tauopathy) - + + + pubmed:25031639 + + p(CONSO:"KXGS motif", pmod(go:0006468 ! "protein phosphorylation")) increases a(GO:"neurofibrillary tangle") + - pmid:19277525 + pubmed:18986241 - complex(p(HGNC:PPP2CA, pmod(Me)), p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + path(MESH:Tauopathies) association p(HGNC:CHRM1) - pmid:19277525 + pubmed:24653673 - complex(p(HGNC:PPP2CA, pmod(Me)), p(HGNC:PPP2R1A)) increases complex(GO:"protein phosphatase type 2A complex") + path(MESH:Tauopathies) negativeCorrelation complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) - + + + pubmed:24653673 + + path(MESH:Tauopathies) negativeCorrelation complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) + - pmid:19277525 + pubmed:29758300 - complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) increases act(p(HGNC:PPME1)) + path(MESH:Tauopathies) association p(HGNC:MAPT) - pmid:19277525 + pubmed:29758300 - complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) increases act(p(HGNC:PPME1)) + path(MESH:Tauopathies) association path(MESH:Dementia) - pmid:19277525 + pubmed:29758300 - complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) increases act(p(HGNC:PPME1)) + path(MESH:Tauopathies) positiveCorrelation p(HGNC:BIN1) - pmid:19277525 + pubmed:30145931 - complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) decreases act(p(HGNC:PPP2CA)) + path(MESH:Tauopathies) positiveCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:19277525 + pubmed:29024336 - complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) decreases act(p(HGNC:PPP2CA)) + path(MESH:Tauopathies) increases path(MESH:"Proteostasis Deficiencies") - pmid:19277525 + pubmed:24027553 - complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) decreases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) + path(MESH:Tauopathies) positiveCorrelation path(MESH:"Cognitive Dysfunction") - pmid:19277525 + pubmed:24027553 - complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) decreases p(HGNC:PPP2CA, pmod(Me, Leu, 309)) + path(MESH:Tauopathies) association p(HGNC:NPEPPS) - - - + + + pubmed:27574109 + + path(MESH:Tauopathies) positiveCorrelation a(CONSO:"Tau oligomers") + - pmid:19277525 + pubmed:29686391 - composite(p(HGNC:PPME1), p(HGNC:PPP2CA), p(HGNC:PPP2R1A)) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) + path(MESH:Tauopathies) positiveCorrelation a(CONSO:"Tau oligomers") - + + + pubmed:27574109 + + path(MESH:Tauopathies) positiveCorrelation p(CONSO:"phosphatase-activating domain") + - pmid:24653673 + pubmed:21734277 - p(HGNC:PPP2CB, pmod(Me, Leu, 309)) increases complex(GO:"protein phosphatase type 2A complex") + path(MESH:Tauopathies) association p(CONSO:"Tau epitope, AT8", pmod(go:0006468 ! "protein phosphorylation")) - pmid:24653673 + pubmed:30108137 - p(HGNC:PPP2CB, pmod(Me, Leu, 309)) increases act(complex(GO:"protein phosphatase type 2A complex")) + path(MESH:Tauopathies) association act(p(MGI:Tfeb)) - pmid:24653673 + pubmed:30108137 - p(HGNC:PPP2CB, pmod(Me, Leu, 309)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2CB), p(HGNC:PPP2R2A)) + path(MESH:Tauopathies) increases p(MGI:Tfeb) - pmid:24653673 + pubmed:30108137 - a(CHEBI:"S-adenosyl-L-methionine") increases act(p(HGNC:LCMT1)) + path(MESH:Tauopathies) increases p(MGI:Tfeb) - pmid:24653673 + pubmed:30108137 - a(CHEBI:"S-adenosyl-L-homocysteine") decreases act(p(HGNC:LCMT1)) + path(MESH:Tauopathies) increases p(MGI:Lamp1) - + + + pubmed:30108137 + + path(MESH:Tauopathies) increases p(MGI:Ctsd) + - pmid:24653673 + pubmed:21882945 - complex(p(HGNC:PPME1), p(HGNC:PPP2CA)) decreases p(HGNC:PPP2CA, pmod(Me)) + path(MESH:Tauopathies) positiveCorrelation bp(GO:"neuron death") - pmid:24653673 + pubmed:28420982 - complex(p(HGNC:PPME1), p(HGNC:PPP2CA)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + path(MESH:Tauopathies) association bp(GO:"neuron death") - pmid:24653673 + pubmed:21882945 - complex(p(HGNC:PPME1), p(HGNC:PPP2CA)) regulates complex(GO:"protein phosphatase type 2A complex") + path(MESH:Tauopathies) negativeCorrelation bp(GO:cognition) - + + + pubmed:30126037 + + path(MESH:Tauopathies) association bp(GO:"cellular senescence") + - pmid:24653673 + pubmed:30126037 - complex(p(HGNC:PPME1), p(HGNC:PPP2CB)) decreases p(HGNC:PPP2CA, pmod(Me)) + path(MESH:Tauopathies) association path(MESH:"Supranuclear Palsy, Progressive") - pmid:24653673 + pubmed:22419736 - complex(p(HGNC:PPME1), p(HGNC:PPP2CB)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + path(MESH:Tauopathies) association a(CONSO:"amyloid-beta 42 oligomers") - pmid:24653673 + pubmed:29191965 - complex(p(HGNC:PPME1), p(HGNC:PPP2CB)) regulates complex(GO:"protein phosphatase type 2A complex") + path(MESH:Tauopathies) association p(HGNC:WNT2) - pmid:24653673 + pubmed:29191965 - p(HGNC:PPP2CB, pmod(Me)) increases act(complex(GO:"protein phosphatase type 2A complex")) + path(MESH:Tauopathies) association p(HGNC:TTBK2) - - - + + + pubmed:29191965 + + path(MESH:Tauopathies) association p(HGNC:GSK3B) + - pmid:24653673 + pubmed:29191965 - p(HGNC:PPP2CA, pmod(Ph, Tyr, 307)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + path(MESH:Tauopathies) association p(HGNC:TAOK1) - pmid:24653673 + pubmed:29191965 - p(HGNC:PPP2CA, pmod(Ph, Tyr, 307)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + path(MESH:Tauopathies) association p(HGNC:CTSE) - pmid:24653673 + pubmed:29191965 - p(HGNC:PPP2CA, pmod(Ph, Tyr, 307)) decreases p(HGNC:MAPT, pmod(Ph)) + path(MESH:Tauopathies) association p(HGNC:CHRNA7) - pmid:24653673 + pubmed:28420982 - p(HGNC:PPP2CB, pmod(Ph, Tyr, 307)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + path(MESH:Tauopathies) association a(CONSO:"Tau annular protofibrils") - pmid:24653673 + pubmed:26631930 - p(HGNC:PPP2CB, pmod(Ph, Tyr, 307)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + path(MESH:Tauopathies) positiveCorrelation p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 18)) - pmid:24653673 + pubmed:26631930 - p(HGNC:PPP2CB, pmod(Ph, Tyr, 307)) decreases p(HGNC:MAPT, pmod(Ph)) + path(MESH:Tauopathies) positiveCorrelation p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) - pmid:24653673 + pubmed:26631930 - p(HGNC:PPP2CA, pmod(Ub)) increases deg(complex(GO:"protein phosphatase type 2A complex")) + path(MESH:Tauopathies) positiveCorrelation p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 394)) - pmid:24653673 + pubmed:26631930 - p(HGNC:PPP2CA, pmod(HBP:nitration, Tyr)) increases act(complex(GO:"protein phosphatase type 2A complex")) + path(MESH:Tauopathies) increases p(HGNC:MAPT, frag("?")) - pmid:24653673 + pubmed:29980653 - p(HGNC:PPP2R5A, pmod(Ph, Ser)) regulates act(complex(GO:"protein phosphatase type 2A complex")) + path(MESH:Tauopathies) isA path(MESH:"Neurodegenerative Diseases") - pmid:24653673 + pubmed:29980653 - p(HGNC:PPP2R5D, pmod(Ph, Ser)) regulates act(complex(GO:"protein phosphatase type 2A complex")) + path(MESH:Tauopathies) positiveCorrelation p(HGNC:MAPT, var("?")) - pmid:24653673 + pubmed:29540553 - p(HGNC:PPP2R1A, pmod(Ph, Ser), pmod(Ph, Thr)) decreases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A)) + path(MESH:Tauopathies) negativeCorrelation p(MGI:Sirt1) - pmid:24653673 + pubmed:25031639 - p(HGNC:PPP2R1A, pmod(Ph, Ser), pmod(Ph, Thr)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + complex(p(HGNC:MAPT), p(HGNC:STUB1)) increases deg(p(HGNC:MAPT)) - pmid:24653673 + pubmed:25031639 - p(HGNC:PPP2R1B, pmod(Ph, Ser), pmod(Ph, Thr)) decreases complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A)) + complex(p(HGNC:MAPT), p(HGNC:STUB1)) increases deg(p(HGNC:MAPT)) - pmid:24653673 + pubmed:25031639 - p(HGNC:PPP2R1B, pmod(Ph, Ser), pmod(Ph, Thr)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + complex(p(HGNC:MAPT), p(HGNC:STUB1)) increases p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) + + + pubmed:25031639 + + p(HGNC:STUB1) increases complex(p(HGNC:MAPT), p(HGNC:STUB1)) + + @@ -98322,100 +99081,137 @@

Statements

- pmid:24653673 + pubmed:25031639 - complex(a(CHEBI:"okadaic acid"), p(HGNC:PPP2CA)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + p(HGNC:STUB1) increases p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) - + + + pubmed:29661268 + + p(HGNC:STUB1) increases p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) + - pmid:24653673 + pubmed:29661268 - complex(a(CHEBI:"okadaic acid"), p(HGNC:PPP2CB)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + p(HGNC:STUB1) increases p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) + + + pubmed:29661268 + + p(HGNC:STUB1) increases p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) + + - pmid:24653673 + pubmed:29661268 - complex(a(PUBCHEM:5311365), p(HGNC:PPP2CA)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + p(HGNC:STUB1) regulates p(HGNC:MAPT) - + + + pubmed:29661268 + + p(HGNC:STUB1) decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) + - pmid:24653673 + pubmed:25374103 - complex(a(PUBCHEM:5311365), p(HGNC:PPP2CB)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + p(HGNC:STUB1) increases deg(p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) - + + + pubmed:29661268 + + p(HGNC:STUB1) negativeCorrelation bp(GO:"neuron death") + - pmid:24653673 + pubmed:29661268 - complex(a(PUBCHEM:6913994), p(HGNC:PPP2CA)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + p(HGNC:STUB1) negativeCorrelation p(CONSO:"Tau aggregates") - + + + pubmed:29661268 + + act(p(HGNC:STUB1)) increases p(CONSO:"Tau aggregates") + - pmid:24653673 + pubmed:29661268 - complex(a(PUBCHEM:6913994), p(HGNC:PPP2CB)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + p(HGNC:STUB1) negativeCorrelation path(DOID:tauopathy) - + + + pubmed:29661268 + + act(p(HGNC:STUB1)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + - pmid:24653673 + pubmed:27491084 - complex(p(HGNC:PPP2CA), p(HGNC:SET)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + p(HGNC:STUB1) decreases path(HP:Neurodegeneration) - + + + pubmed:27491084 + + p(HGNC:STUB1) decreases p(HGNC:ATXN3, var("?")) + - pmid:24653673 + pubmed:27491084 - complex(p(HGNC:PPP2CB), p(HGNC:SET)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + p(HGNC:STUB1) decreases p(HGNC:HTT, var("?")) @@ -98426,9 +99222,9 @@

Statements

- pmid:24653673 + pubmed:22908190 - complex(p(HGNC:ANP32A), p(HGNC:PPP2CA)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + p(HGNC:STUB1) increases complex(p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)), p(HGNC:STUB1)) @@ -98437,108 +99233,102 @@

Statements

+ + - pmid:24653673 + pubmed:25036637 - complex(p(HGNC:ANP32A), p(HGNC:PPP2CB)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + p(HGNC:STUB1) increases complex(p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) - - - pmid:24653673 - - a(CHEBI:"metal cation") increases act(complex(GO:"protein phosphatase type 2A complex")) - + + + - pmid:24653673 + pubmed:25036637 - a(CHEBI:ceramide) increases act(complex(GO:"protein phosphatase type 2A complex")) + p(HGNC:STUB1) directlyIncreases complex(p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) + + - pmid:29758300 + pubmed:25036637 - a(CHEBI:ceramide) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:STUB1) directlyIncreases complex(p(HGNC:STUB1), p(INTERPRO:"Heat shock protein Hsp90 family")) - pmid:24653673 + pubmed:25036637 - a(CHEBI:polyamine) increases act(complex(GO:"protein phosphatase type 2A complex")) + p(HGNC:STUB1) regulates bp(GO:"cellular protein catabolic process") - pmid:21882945 + pubmed:24027553 - a(CHEBI:polyamine) decreases act(p(INTERPRO:"Heat shock protein 70 family")) + p(HGNC:STUB1) increases p(HGNC:MAPT, pmod(go:0070936 ! "protein K48-linked ubiquitination")) - - - - - pmid:24653673 + pubmed:26631930 - complex(p(HGNC:LCMT1), p(HGNC:PPP2CA)) regulates complex(GO:"protein phosphatase type 2A complex") + p(HGNC:STUB1) increases p(HGNC:MAPT, pmod(go:0070936 ! "protein K48-linked ubiquitination")) - - - - - pmid:24653673 + pubmed:24027553 - complex(p(HGNC:LCMT1), p(HGNC:PPP2CB)) regulates complex(GO:"protein phosphatase type 2A complex") + p(HGNC:STUB1) increases p(HGNC:MAPT, pmod(go:0070534 ! "protein K63-linked ubiquitination")) - - - - - pmid:24653673 + pubmed:23528736 - complex(p(HGNC:IGBP1), p(HGNC:PPP2CB)) regulates complex(GO:"protein phosphatase type 2A complex") + p(HGNC:STUB1) association path(MESH:"Neurodegenerative Diseases") - + + + pubmed:23528736 + + p(HGNC:STUB1) association path(MESH:"Alzheimer Disease") + - pmid:24653673 + pubmed:29311797 - complex(p(HGNC:PPP2CA), p(HGNC:PTPA)) regulates complex(GO:"protein phosphatase type 2A complex") + p(HGNC:STUB1) association path(MESH:"Alzheimer Disease") @@ -98549,9 +99339,9 @@

Statements

- pmid:24653673 + pubmed:21882945 - complex(p(HGNC:PPP2CB), p(HGNC:PTPA)) regulates complex(GO:"protein phosphatase type 2A complex") + act(p(HGNC:STUB1)) increases bp(GO:"protein catabolic process") @@ -98564,135 +99354,167 @@

Statements

- pmid:24653673 + pubmed:21882945 - complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) increases complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) + act(p(HGNC:STUB1)) increases bp(GO:"protein ubiquitination") + + - pmid:24653673 + pubmed:25374103 - complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) increases complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) + p(HGNC:STUB1) regulates act(p(HGNC:CASP3)) + + + + - pmid:24653673 + pubmed:25374103 - complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) increases complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) + p(HGNC:STUB1) increases deg(p(CONSO:"Tau C3")) - pmid:24653673 + pubmed:25374103 - complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) positiveCorrelation p(FPLX:PPP2, pmod(Me)) + p(HGNC:STUB1) decreases p(CONSO:"Tau C3") - pmid:24653673 + pubmed:25374103 - complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) association p(FPLX:PPP2, pmod(Me)) + p(HGNC:STUB1) increases deg(p(CONSO:"Tau C3")) + + + + - pmid:24653673 + pubmed:25374103 - complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) regulates p(FPLX:PPP2, pmod(Me)) + p(HGNC:STUB1) causesNoChange bp(GO:"cell death") + + + + + + + + + + + + + + + + - pmid:24653673 + pubmed:25374103 - complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) negativeCorrelation path(MESH:Tauopathies) + p(HGNC:STUB1) increases complex(p(HGNC:HSPA8), p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")), p(HGNC:STUB1)) + + - pmid:24653673 + pubmed:25374103 - complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) decreases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:STUB1) increases deg(p(CONSO:"4R tau", var("p.Lys280del"))) - pmid:24653673 + pubmed:25374103 - complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) decreases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:STUB1) decreases act(p(FPLX:Caspase)) - pmid:24653673 + pubmed:25374103 - complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) increases complex(a(GO:microtubule), p(HGNC:MAPT)) + p(HGNC:STUB1) increases deg(p(FPLX:Caspase)) + + - pmid:24653673 + pubmed:29311797 - complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) regulates a(GO:microtubule) + p(HGNC:STUB1) association path(MESH:"Huntington Disease") - pmid:24653673 + pubmed:29311797 - complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) regulates bp(MESH:"Neuronal Outgrowth") + p(HGNC:STUB1) association path(MESH:"Parkinson Disease") - pmid:24653673 + pubmed:29311797 - complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:STUB1) association path(MESH:"Cystic Fibrosis") - pmid:24653673 + pubmed:29311797 - complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:STUB1) association path(MESH:Neoplasms) + + - pmid:24653673 + pubmed:14612456 - complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) regulates p(HGNC:MAPT) + p(HGNC:STUB1) isA complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")), p(HGNC:STUB1), p(HGNC:UBE2D2)) @@ -98703,1206 +99525,1199 @@

Statements

- - - pmid:24653673 + pubmed:27325702 - complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) decreases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:STUB1) association p(CONSO:"APP, ACR") - pmid:24653673 + pubmed:27325702 - complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) decreases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:STUB1) isA complex(GO:"ubiquitin ligase complex") - pmid:24653673 + pubmed:25031639 - complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) negativeCorrelation path(MESH:"Alzheimer Disease") + complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:"Heat shock 70kDa proteins")) increases deg(p(HGNC:MAPT)) - - - - - pmid:24653673 + pubmed:30935091 - complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) increases complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) + p(HGNCGENEFAMILY:"Heat shock 70kDa proteins") decreases bp(MESH:"Oxidative Stress") - pmid:24653673 + pubmed:30935091 - complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) increases complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) + p(HGNCGENEFAMILY:"Heat shock 70kDa proteins") increases bp(MESH:"Cell Survival") - pmid:24653673 + pubmed:29661268 - complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) increases complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) + p(HGNCGENEFAMILY:"Heat shock 70kDa proteins") negativeCorrelation p(CONSO:"Tau aggregates") + + - pmid:24653673 + pubmed:25031639 - complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) positiveCorrelation p(FPLX:PPP2, pmod(Me)) + complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:"Heat shock 90kDa proteins")) increases deg(p(HGNC:MAPT)) + + + + + + + + - pmid:24653673 + pubmed:22372633 - complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) association p(FPLX:PPP2, pmod(Me)) + act(p(HGNCGENEFAMILY:"Heat shock 90kDa proteins"), ma(GO:"vascular endothelial growth factor receptor 1 binding")) increases act(p(HGNCGENEFAMILY:"Heat shock 70kDa proteins"), ma(GO:"vascular endothelial growth factor receptor 1 binding")) - pmid:24653673 + pubmed:22372633 - complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) regulates p(FPLX:PPP2, pmod(Me)) + act(p(HGNCGENEFAMILY:"Heat shock 90kDa proteins"), ma(GO:"vascular endothelial growth factor receptor 2 binding")) increases act(p(HGNCGENEFAMILY:"Heat shock 70kDa proteins"), ma(GO:"vascular endothelial growth factor receptor 2 binding")) + + + + - pmid:24653673 + pubmed:29844403 - complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) negativeCorrelation path(MESH:Tauopathies) + p(HGNCGENEFAMILY:"Heat shock 90kDa proteins") association p(HGNC:HDAC6) + + - pmid:24653673 + pubmed:25031639 - complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) decreases p(HGNC:MAPT, pmod(Ph)) + a(MESH:"Histone Deacetylase Inhibitors") increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) - pmid:24653673 + pubmed:25031639 - complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) decreases p(HGNC:MAPT, pmod(Ph)) + a(MESH:"Histone Deacetylase Inhibitors") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:24653673 + pubmed:25031639 - complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) increases complex(a(GO:microtubule), p(HGNC:MAPT)) + p(CONSO:"KXGS motif", pmod(go:0006473 ! "protein acetylation")) decreases p(CONSO:"KXGS motif", pmod(go:0006468 ! "protein phosphorylation")) - pmid:24653673 + pubmed:25031639 - complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) regulates a(GO:microtubule) + p(CONSO:"KXGS motif", pmod(go:0006473 ! "protein acetylation")) decreases p(CONSO:"Tau aggregates") - pmid:24653673 + pubmed:25031639 - complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) regulates bp(MESH:"Neuronal Outgrowth") + p(CONSO:"KXGS motif", pmod(go:0006473 ! "protein acetylation")) decreases p(CONSO:"Tau aggregates") - pmid:24653673 + pubmed:25031639 - complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) negativeCorrelation path(MESH:"Alzheimer Disease") + p(CONSO:"KXGS motif", pmod(go:0006473 ! "protein acetylation")) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:24653673 + pubmed:25031639 - complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) negativeCorrelation path(MESH:"Alzheimer Disease") + p(CONSO:"KXGS motif", pmod(go:0006473 ! "protein acetylation")) increases deg(p(HGNC:MAPT)) - pmid:24653673 + pubmed:25031639 - complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) regulates p(HGNC:MAPT) + p(CONSO:"KXGS motif", pmod(go:0006473 ! "protein acetylation")) decreases path(DOID:tauopathy) - - - - - - - - - pmid:24653673 + pubmed:25031639 - complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) decreases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 365)) decreases complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)), p(HGNC:STUB1)) - pmid:24653673 + pubmed:25031639 - complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) decreases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) increases deg(p(HGNC:MAPT)) - pmid:24653673 + pubmed:29661268 - complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) increases p(HGNC:MAPT) - - - - - - - - - - - - - - - - - - - - - - - - - pmid:24653673 + pubmed:8391280 - g(HGNC:PPP2CA) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination"), loc(CONSO:"paired helical filaments")) increases deg(p(HGNC:MAPT)) - pmid:24653673 + pubmed:25378699 - r(HGNC:PPP2CA) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) increases deg(p(HGNC:MAPT)) - pmid:22299660 + pubmed:25031639 - r(HGNC:PPP2CA) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) negativeCorrelation bp(GO:"proteasomal protein catabolic process") - pmid:24653673 + pubmed:25031639 - g(HGNC:PPP2CB) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) negativeCorrelation bp(GO:"lysosomal protein catabolic process") - pmid:24653673 + pubmed:25031639 - r(HGNC:PPP2CB) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) increases p(MESH:"Neurofibrillary Tangles") - pmid:22299660 + pubmed:29661268 - r(HGNC:PPP2CB) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) negativeCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"), loc(CONSO:"KXGS motif")) - pmid:24653673 + pubmed:14612456 - r(HGNC:PPP2R2C) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:24653673 + pubmed:29661268 - r(HGNC:PPP2R5E) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:24653673 + pubmed:29661268 - path(MESH:Tauopathies) negativeCorrelation complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) + p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) positiveCorrelation path(DOID:"Alzheimer's disease") - pmid:24653673 + pubmed:29661268 - path(MESH:Tauopathies) negativeCorrelation complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) + p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) negativeCorrelation path(DOID:tauopathy) - pmid:29758300 + pubmed:29661268 - path(MESH:Tauopathies) association p(HGNC:MAPT) + p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) increases act(p(MESH:"Proteasome Endopeptidase Complex")) - pmid:29980653 + pubmed:29661268 - path(MESH:Tauopathies) positiveCorrelation p(HGNC:MAPT) + p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) decreases act(p(MESH:"Proteasome Endopeptidase Complex")) - pmid:29758300 + pubmed:29661268 - path(MESH:Tauopathies) association path(MESH:Dementia) + p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) increases p(CONSO:"Tau aggregates") - pmid:29758300 + pubmed:22908190 - path(MESH:Tauopathies) positiveCorrelation p(HGNC:BIN1) + p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:30145931 + pubmed:24027553 - path(MESH:Tauopathies) positiveCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) association path(MESH:"Neurofibrillary Tangles") + + - pmid:29024336 + pubmed:14612456 - path(MESH:Tauopathies) increases path(MESH:"Proteostasis Deficiencies") + p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) positiveCorrelation p(HGNC:UBE2D2) - pmid:24027553 + pubmed:24905733 - path(MESH:Tauopathies) positiveCorrelation path(MESH:"Cognitive Dysfunction") + p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) decreases complex(a(MESH:Microtubules), p(HGNC:MAPT)) - pmid:24027553 + pubmed:25031639 - path(MESH:Tauopathies) association p(HGNC:NPEPPS) + complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)), p(HGNCGENEFAMILY:"Heat shock 90kDa proteins")) increases deg(p(HGNC:MAPT)) + + - pmid:27574109 + pubmed:25031639 - path(MESH:Tauopathies) positiveCorrelation a(HBP:"Tau oligomers") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) increases complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)), p(HGNCGENEFAMILY:"Heat shock 90kDa proteins")) - pmid:29686391 + pubmed:22299660 - path(MESH:Tauopathies) positiveCorrelation a(HBP:"Tau oligomers") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27574109 + pubmed:22419736 - path(MESH:Tauopathies) positiveCorrelation a(HBP:"phosphatase-activating domain") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:21734277 + pubmed:28420982 - path(MESH:Tauopathies) association p(HBP:"Tau epitope, AT8", pmod(Ph)) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:30108137 + pubmed:26458742 - path(MESH:Tauopathies) association act(p(MGI:Tfeb)) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:30108137 + pubmed:22611162 - path(MESH:Tauopathies) increases p(MGI:Tfeb) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) association p(HGNC:MAPT, var("p.Val277Met")) - pmid:30108137 + pubmed:28420982 - path(MESH:Tauopathies) increases p(MGI:Tfeb) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) positiveCorrelation path(MESH:"Frontotemporal Dementia") - pmid:30108137 + pubmed:14612456 - path(MESH:Tauopathies) increases p(MGI:Lamp1) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) isA p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:30108137 + pubmed:20071522 - path(MESH:Tauopathies) increases p(MGI:Ctsd) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) isA p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation")) - pmid:21882945 + pubmed:20071522 - path(MESH:Tauopathies) positiveCorrelation bp(GO:"neuron death") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) association complex(p(HGNC:FKBP5), p(HGNC:MAPT)) - pmid:28420982 + pubmed:20071522 - path(MESH:Tauopathies) association bp(GO:"neuron death") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) positiveCorrelation p(HGNC:FKBP5) - pmid:21882945 + pubmed:21367866 - path(MESH:Tauopathies) negativeCorrelation bp(GO:cognition) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) positiveCorrelation p(HGNC:CDC37) - pmid:30126037 + pubmed:22764226 - path(MESH:Tauopathies) association bp(GO:"cellular senescence") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) negativeCorrelation p(MGI:Ppp2ca, pmod(go:0006479 ! "protein methylation")) - pmid:30126037 + pubmed:17078951 - path(MESH:Tauopathies) association path(MESH:"Supranuclear Palsy, Progressive") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) positiveCorrelation p(FPLX:PKA) - pmid:22419736 + pubmed:22156579 - path(MESH:Tauopathies) association a(HBP:"amyloid-beta 42 oligomers") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) positiveCorrelation p(CONSO:"Tau epitope, PHF1") - pmid:29191965 + pubmed:25331948 - path(MESH:Tauopathies) association p(HGNC:WNT2) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) partOf p(CONSO:"Tau epitope, PHF1") - pmid:29191965 + pubmed:22833681 - path(MESH:Tauopathies) association p(HGNC:TTBK2) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) partOf p(CONSO:"Tau epitope, PHF1") - pmid:29191965 + pubmed:23948915 - path(MESH:Tauopathies) association p(HGNC:GSK3B) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) negativeCorrelation bp(GO:"apoptotic process") - pmid:29191965 + pubmed:19459590 - path(MESH:Tauopathies) association p(HGNC:TAOK1) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) decreases complex(a(MESH:Microtubules), p(HGNC:MAPT)) - pmid:29191965 + pubmed:22833681 - path(MESH:Tauopathies) association p(HGNC:CTSE) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) positiveCorrelation p(HGNC:MAPT, pmod(CONSO:O-GlcNAcylation)) + + - pmid:29191965 + pubmed:25031639 - path(MESH:Tauopathies) association p(HGNC:CHRNA7) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) increases complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)), p(HGNC:STUB1)) - pmid:28420982 + pubmed:25031639 - path(MESH:Tauopathies) association a(HBP:"Tau annular protofibrils") + complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)), p(HGNCGENEFAMILY:"Heat shock 90kDa proteins")) increases deg(p(HGNC:MAPT)) + + - pmid:26631930 + pubmed:25031639 - path(MESH:Tauopathies) positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) increases complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)), p(HGNCGENEFAMILY:"Heat shock 90kDa proteins")) - pmid:26631930 + pubmed:22299660 - path(MESH:Tauopathies) positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:26631930 + pubmed:22419736 - path(MESH:Tauopathies) positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:26631930 + pubmed:26458742 - path(MESH:Tauopathies) increases p(HGNC:MAPT, frag("?")) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:29980653 + pubmed:22611162 - path(MESH:Tauopathies) isA path(MESH:"Neurodegenerative Diseases") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) association p(HGNC:MAPT, var("p.Val277Met")) - pmid:29540553 + pubmed:24760868 - path(MESH:Tauopathies) negativeCorrelation p(MGI:Sirt1) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) increases p(HGNC:MAPT, loc(MESH:"Dendritic Spines")) - pmid:24653673 + pubmed:14612456 - p(FPLX:PPP2, pmod(Me, Tyr, 307)) association a(GO:"neurofibrillary tangle") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) isA p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:24653673 + pubmed:21367866 - p(FPLX:PPP2, pmod(Me, Tyr, 307)) association p(HGNC:MAPT, pmod(Ph)) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) positiveCorrelation p(HGNC:CDC37) - pmid:24653673 + pubmed:22764226 - p(HGNC:SET, frag("?")) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) negativeCorrelation p(MGI:Ppp2ca, pmod(go:0006479 ! "protein methylation")) - pmid:24653673 + pubmed:17078951 - p(HGNC:SET, frag("?")) increases path(MESH:"Alzheimer Disease") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) negativeCorrelation p(FPLX:PKA) - pmid:24653673 + pubmed:11943212 - p(HGNC:SET, frag("?")) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) partOf p(CONSO:"Tau epitope, AD2") - pmid:24653673 + pubmed:22156579 - p(FPLX:CAPN) increases p(HGNC:IGBP1, frag("?")) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) positiveCorrelation p(CONSO:"Tau epitope, PHF1") - pmid:22908190 + pubmed:25331948 - p(FPLX:CAPN) increases deg(p(HGNC:MAPT)) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) partOf p(CONSO:"Tau epitope, PHF1") - pmid:29626319 + pubmed:22833681 - p(FPLX:CAPN) increases deg(p(HGNC:MAPT)) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) partOf p(CONSO:"Tau epitope, PHF1") - pmid:29626319 + pubmed:19459590 - p(FPLX:CAPN) increases p(HGNC:MAPT, frag("?")) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) decreases complex(a(MESH:Microtubules), p(HGNC:MAPT)) + + - pmid:26118667 + pubmed:25031639 - act(p(FPLX:CAPN)) positiveCorrelation rxn(reactants(p(RGD:Cdk5r1)), products(p(HBP:"CDK5R1 p25"))) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) increases complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)), p(HGNC:STUB1)) - pmid:26118667 + pubmed:25031639 - act(p(FPLX:CAPN)) increases deg(p(HGNC:NFKBIA)) + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation), pmod(go:0016567 ! "protein ubiquitination")) increases p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) - pmid:26118667 + pubmed:29661268 - act(p(FPLX:CAPN)) increases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation), pmod(go:0016567 ! "protein ubiquitination")) increases p(CONSO:"Tau aggregates") - pmid:24653673 + pubmed:29661268 - p(HGNC:IGBP1, frag("?")) regulates complex(GO:"protein phosphatase type 2A complex") + p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation), pmod(go:0016567 ! "protein ubiquitination")) negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:24653673 + pubmed:25031639 - p(HGNC:IGBP1, frag("?")) positiveCorrelation deg(p(HGNC:PPP2CA)) + bp(GO:"lysosomal protein catabolic process") negativeCorrelation p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) - pmid:24653673 + pubmed:21722302 - p(HGNC:IGBP1, frag("?")) positiveCorrelation deg(p(HGNC:PPP2CB)) + bp(GO:"lysosomal protein catabolic process") increases deg(p(MESH:Proteins, pmod(CONSO:misfolded))) - pmid:24653673 + pubmed:27209302 - p(HGNC:PPP2CA, var("p.Leu309Ala")) increases p(HGNC:MAPT, pmod(Ph)) + bp(GO:"lysosomal protein catabolic process") increases deg(p(CONSO:"amyloid-beta oligomers")) - pmid:24653673 + pubmed:29758300 - p(HGNC:PPP2CB, var("p.Leu309Ala")) increases p(HGNC:MAPT, pmod(Ph)) + bp(GO:"lysosomal protein catabolic process") decreases a(GO:autolysosome) - pmid:24653673 + pubmed:29758300 - a(GO:"neurofilament cytoskeleton") negativeCorrelation act(p(HGNC:GSK3B)) + bp(GO:"lysosomal protein catabolic process") negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:24653673 + pubmed:22908190 - a(GO:"neurofilament cytoskeleton") negativeCorrelation act(p(HGNC:CDK5)) + bp(GO:"lysosomal protein catabolic process") negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:24653673 + pubmed:29758300 - a(GO:"neurofilament cytoskeleton") negativeCorrelation act(p(FPLX:ERK)) + bp(GO:"lysosomal protein catabolic process") positiveCorrelation bp(GO:autophagy) - pmid:21722302 + pubmed:22908190 - a(GO:"neurofilament cytoskeleton") association path(MESH:"Amyotrophic Lateral Sclerosis") + bp(GO:"lysosomal protein catabolic process") positiveCorrelation bp(GO:autophagy) - pmid:24653673 + pubmed:22908190 - bp(GO:"negative regulation of synaptic plasticity") positiveCorrelation act(p(HGNC:GSK3B)) + bp(GO:"lysosomal protein catabolic process") negativeCorrelation act(p(HGNC:RAB5A)) - pmid:24653673 + pubmed:22908190 - bp(GO:"negative regulation of synaptic plasticity") positiveCorrelation act(p(HGNC:CDK5)) + bp(GO:"lysosomal protein catabolic process") increases bp(GO:"axonal transport") - pmid:24653673 + pubmed:22908190 - bp(GO:"negative regulation of synaptic plasticity") positiveCorrelation act(p(FPLX:ERK)) + bp(GO:"lysosomal protein catabolic process") negativeCorrelation bp(GO:endocytosis) - - - - - pmid:30985105 + pubmed:22908190 - complex(a(GO:microtubule), p(HGNC:MAPT)) increases act(p(HGNC:MAPT)) + bp(GO:"lysosomal protein catabolic process") decreases path(CONSO:Neurodegeneration) - pmid:26631930 + pubmed:22908190 - complex(a(GO:microtubule), p(HGNC:MAPT)) increases bp(GO:"microtubule bundle formation") + bp(GO:"lysosomal protein catabolic process") decreases path(CONSO:Neurodegeneration) - pmid:26631930 + pubmed:22908190 - complex(a(GO:microtubule), p(HGNC:MAPT)) increases bp(GO:"actin cytoskeleton reorganization") + bp(GO:"lysosomal protein catabolic process") decreases p(HGNC:MAP1LC3B) - pmid:26631930 + pubmed:22908190 - complex(a(GO:microtubule), p(HGNC:MAPT)) negativeCorrelation a(HBP:"Tau aggregates") + bp(GO:"lysosomal protein catabolic process") decreases p(HGNC:SQSTM1) - pmid:26631930 + pubmed:22908190 - complex(a(GO:microtubule), p(HGNC:MAPT)) decreases a(HBP:"Tau aggregates") + bp(GO:"lysosomal protein catabolic process") decreases p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination")) - - - - - pmid:24653673 + pubmed:22908190 - bp(GO:"one-carbon metabolic process") association p(FPLX:PPP2, pmod(Me)) + bp(GO:"lysosomal protein catabolic process") increases deg(a(MESH:"Amyloid beta-Peptides")) - pmid:24653673 + pubmed:22908190 - bp(GO:"one-carbon metabolic process") decreases p(HGNC:MAPT, pmod(Ph)) + bp(GO:"lysosomal protein catabolic process") increases deg(a(CHEBI:amyloid-beta)) - pmid:24653673 + pubmed:22908190 - bp(GO:"one-carbon metabolic process") decreases bp(HBP:amyloidogenesis) + bp(GO:"lysosomal protein catabolic process") increases deg(a(CHEBI:amyloid-beta)) - pmid:24653673 + pubmed:22908190 - bp(GO:"one-carbon metabolic process") decreases p(HGNC:APP, pmod(Ph, Thr, 668)) + bp(GO:"lysosomal protein catabolic process") decreases a(CHEBI:amyloid-beta) - pmid:24653673 + pubmed:22908190 - bp(GO:"one-carbon metabolic process") increases bp(GO:cognition) + bp(GO:"lysosomal protein catabolic process") increases bp(GO:learning) - pmid:24653673 + pubmed:22908190 - bp(GO:"one-carbon metabolic process") decreases act(a(CHEBI:"amyloid-beta")) + bp(GO:"lysosomal protein catabolic process") increases bp(GO:memory) - pmid:24653673 + pubmed:25031639 - a(CHEBI:folates) decreases p(FPLX:PPP2, pmod(Me)) + p(HGNC:MAPT, pmod(CONSO:"Tau aggregates"), pmod(go:0016567 ! "protein ubiquitination")) decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) - pmid:24653673 + pubmed:25031639 - a(CHEBI:folates) increases p(HGNC:MAPT, pmod(Ph)) + act(complex(GO:microtubule), ma(GO:"microtubule motor activity")) negativeCorrelation act(p(HGNC:HDAC6)) - pmid:24653673 + pubmed:25031639 - a(CHEBI:folates) increases p(HGNC:APP, pmod(Ph)) + act(complex(GO:microtubule), ma(GO:"microtubule motor activity")) negativeCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:24653673 + pubmed:6543144 - path(MESH:"Vitamin B Deficiency") decreases p(FPLX:PPP2, pmod(Me)) + complex(GO:microtubule) association complex(complex(GO:neurofilament), p(HGNC:MAPT)) - pmid:24653673 + pubmed:10464280 - path(MESH:"Vitamin B Deficiency") increases p(HGNC:MAPT, pmod(Ph)) + act(complex(GO:microtubule)) positiveCorrelation p(CONSO:"microtubule-binding region") - pmid:24653673 + pubmed:10464280 - path(MESH:"Vitamin B Deficiency") increases p(HGNC:APP, pmod(Ph)) + complex(GO:microtubule) association p(HGNC:PPP2CA) + + - pmid:24653673 + pubmed:10464280 - a(CHEBI:homocysteine) negativeCorrelation p(FPLX:PPP2, pmod(Me)) + complex(GO:microtubule) association p(HGNC:MAPT) + + - pmid:24653673 + pubmed:10464280 - a(CHEBI:homocysteine) positiveCorrelation p(HGNC:MAPT, pmod(Ph)) + act(complex(GO:microtubule)) directlyDecreases act(complex(GO:"protein phosphatase type 2A complex")) - pmid:24653673 + pubmed:18500754 - a(CHEBI:homocysteine) positiveCorrelation p(HGNC:APP, pmod(Ph)) + act(complex(GO:microtubule)) negativeCorrelation act(p(HGNC:HSPA8)) - pmid:28632203 + pubmed:18500754 - a(CHEBI:homocysteine) biomarkerFor path(MESH:"Alzheimer Disease") + complex(GO:microtubule) association p(INTERPRO:"Heat shock protein 70 family") - + + + pubmed:20133804 + + complex(GO:microtubule) positiveCorrelation bp(GO:"microtubule polymerization") + - pmid:26323690 + pubmed:25031639 - bp(GO:"microtubule depolymerization") negativeCorrelation p(HGNC:KIF2A, pmod(Ph)) + g(HGNC:HDAC6) positiveCorrelation bp(GO:cognition) - pmid:12428809 + pubmed:25031639 - p(HGNC:MAPK9) increases p(HGNC:MAPT, pmod(Ph)) + g(HGNC:HDAC6) causesNoChange path(MESH:"Plaque, Amyloid") - pmid:12428809 + pubmed:25031639 - p(HGNC:MARK1) increases p(HGNC:MAPT, pmod(Ph)) + composite(p(HGNC:HDAC6), p(HGNC:SOD1, var("?"))) decreases path(MESH:Neuroprotection) - pmid:26631930 + pubmed:25031639 - p(HGNC:MARK1) directlyIncreases p(HGNC:MAPT, pmod(Ph)) + composite(p(HGNC:HDAC6), p(HGNC:SOD1, var("?"))) decreases bp(MESH:"Cell Survival") - pmid:26631930 + pubmed:25031639 - p(HGNC:MARK1) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + composite(p(HGNC:HDAC6), p(HGNC:SOD1, var("?"))) decreases bp(GO:"motor neuron axon guidance") + + + + - pmid:21311567 + pubmed:30688256 - act(p(HGNC:MARK1)) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + p(HGNC:SOD1, var("?")) association bp(GO:mitophagy) - pmid:22952452 + pubmed:30688256 - act(p(HGNC:MARK1), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + p(HGNC:SOD1, var("?")) increases bp(GO:mitophagy) - pmid:23001711 + pubmed:30688256 - p(HGNC:MARK1) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + p(HGNC:SOD1, var("?")) increases act(p(HGNC:PRKN)) - pmid:21311567 + pubmed:30688256 - act(p(HGNC:MARK1)) decreases bp(GO:"microtubule polymerization") + p(HGNC:SOD1, var("?")) increases deg(p(HGNC:RHOT1)) - pmid:12428809 + pubmed:30688256 - p(HGNC:CAMK2B) increases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:SOD1, var("?")) decreases bp(GO:"retrograde axonal transport of mitochondrion") - pmid:21722302 + pubmed:21722302 - p(HGNC:CAMK2B) increases act(p(HGNC:PRKAA1)) + p(HGNC:SOD1, var("?")) association path(MESH:"Amyotrophic Lateral Sclerosis") - pmid:21722302 + pubmed:21722302 - p(HGNC:CAMK2B) increases act(complex(GO:"Atg1/ULK1 kinase complex")) + p(HGNC:SOD1, var("?")) association path(MESH:"Amyotrophic Lateral Sclerosis") - pmid:27796283 + pubmed:14556719 - p(HGNC:CAMK2B) increases p(HBP:"Kalirin 7", pmod(Ph, Thr, 95)) + p(HGNC:SOD1, var("?")) association path(MESH:"Amyotrophic Lateral Sclerosis") - pmid:12428809 + pubmed:30985105 - p(FPLX:CK2) increases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:SOD1, var("?")) increases path(MESH:"Amyotrophic Lateral Sclerosis") - pmid:12428809 + pubmed:21722302 - p(FPLX:PPP1) decreases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:SOD1, var("?")) increases bp(MESH:"Unfolded Protein Response") - pmid:21734277 + pubmed:21722302 - act(p(FPLX:PPP1)) decreases bp(GO:"axonal transport") + p(HGNC:SOD1, var("?")) increases p(MESH:"Molecular Chaperones") @@ -99911,81 +100726,85 @@

Statements

- pmid:21489990 + pubmed:21722302 - act(p(FPLX:PPP1)) decreases p(RGD:Mapt, pmod(Ph, Ser, 262)) + p(HGNC:SOD1, var("?")) increases bp(MESH:"Endoplasmic Reticulum Stress") + + - pmid:12428809 + pubmed:14556719 - p(FPLX:PPP3) decreases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:SOD1, var("?")) increases bp(GO:"response to oxidative stress") - pmid:12428809 + pubmed:14556719 - p(HBP:"4R tau") increases path(MESH:"Wallerian Degeneration") + p(HGNC:SOD1, var("?")) increases bp(GO:"response to oxidative stress") - pmid:12428809 + pubmed:14556719 - p(HBP:"4R tau") increases path(MESH:"Muscular Atrophy") + p(HGNC:SOD1, var("?")) increases bp(GO:"cell death") - pmid:12428809 + pubmed:14556719 - p(HBP:"4R tau") increases path(HP:Neurodegeneration) + p(HGNC:SOD1, var("?")) negativeCorrelation act(complex(GO:"proteasome complex")) - pmid:12428809 + pubmed:14556719 - p(HBP:"4R tau") positiveCorrelation path(MESH:"Frontotemporal Dementia") + p(HGNC:SOD1, var("?")) increases act(complex(GO:"proteasome complex")) + + - pmid:26751493 + pubmed:18930136 - p(HBP:"4R tau") positiveCorrelation path(MESH:"Frontotemporal Dementia") + p(HGNC:SOD1, var("?")) association p(HGNC:SQSTM1) - pmid:12428809 + pubmed:27181519 - p(HBP:"4R tau") positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:SOD1, var("?")) association bp(GO:autophagy) - pmid:26631930 + pubmed:30837838 - p(HBP:"4R tau") positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:SOD1, var("?")) increases p(HGNC:TARDBP, frag("274_414")) @@ -99994,458 +100813,469 @@

Statements

- pmid:26751493 + pubmed:25031639 - p(HBP:"4R tau") positiveCorrelation path(HBP:"Corticobasal Degeneration") + p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) positiveCorrelation a(MESH:Microtubules) - pmid:26631930 + pubmed:22372633 - p(HBP:"4R tau") positiveCorrelation path(HBP:"Corticobasal Degeneration") + p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) increases a(MESH:Microtubules) - pmid:26751493 + pubmed:25031639 - p(HBP:"4R tau") positiveCorrelation path(HBP:"Argyrophilic Grain Disease") + p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) positiveCorrelation bp(GO:"microtubule cytoskeleton organization") - pmid:26751493 + pubmed:25031639 - p(HBP:"4R tau") positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") + p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) association p(CONSO:"KXGS motif", pmod(go:0006468 ! "protein phosphorylation")) - pmid:26631930 + pubmed:22372633 - p(HBP:"4R tau") positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") + p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) positiveCorrelation bp(GO:"axonal transport of mitochondrion") - pmid:26631930 + pubmed:22372633 - p(HBP:"4R tau") directlyIncreases complex(a(GO:microtubule), p(HBP:"4R tau")) + p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) decreases bp(GO:"microtubule depolymerization") + + + + + + + + + + - pmid:23407988 + pubmed:25031639 - p(HBP:"4R tau") isA p(HGNC:MAPT) + a(CHEBI:"epothilone D") positiveCorrelation a(MESH:Microtubules) - pmid:23407988 + pubmed:25031639 - p(HBP:"4R tau") partOf a(HBP:pretangles) + a(CHEBI:"epothilone D") increases a(MESH:Microtubules, loc(MESH:Axons)) - pmid:23407988 + pubmed:25031639 - p(HBP:"4R tau") partOf complex(GO:"neurofibrillary tangle") + a(CHEBI:"epothilone D") positiveCorrelation bp(GO:cognition) - pmid:23407988 + pubmed:30116051 - p(HBP:"4R tau") positiveCorrelation a(HBP:"CA4 field of hippocampus") + a(CHEBI:"epothilone D") increases bp(GO:cognition) - pmid:23407988 + pubmed:25031639 - p(HBP:"4R tau") positiveCorrelation a(HBP:"CA3 field of hippocampus") + a(CHEBI:"epothilone D") decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:23407988 + pubmed:30116051 - p(HBP:"4R tau") positiveCorrelation a(HBP:"CA2 field of hippocampus") + a(CHEBI:"epothilone D") increases a(GO:microtubule) - pmid:23407988 + pubmed:25031639 - p(HBP:"4R tau") positiveCorrelation a(HBP:"CA1 field of hippocampus") + bp(GO:"microtubule cytoskeleton organization") positiveCorrelation p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) - pmid:23407988 + pubmed:18583940 - p(HBP:"4R tau") positiveCorrelation a(HBP:"Brodmann (1909) area 36") + bp(GO:"microtubule cytoskeleton organization") decreases path(MESH:"Neurodegenerative Diseases") - pmid:23407988 + pubmed:24173717 - p(HBP:"4R tau") partOf complex(GO:"neuronal cell body") + bp(GO:"microtubule cytoskeleton organization") negativeCorrelation p(HGNC:TUBB6) - pmid:23407988 + pubmed:30606258 - p(HBP:"4R tau") partOf complex(GO:dendrite) + bp(GO:"microtubule cytoskeleton organization") increases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation", Lys, 40)) - pmid:23407988 + pubmed:25031639 - p(HBP:"4R tau") partOf a(MESH:Neuropil) + deg(complex(a(MESH:Microtubules), p(HGNC:MAPT))) regulates p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) - pmid:28775333 + pubmed:25031639 - p(HBP:"4R tau") negativeCorrelation p(MGI:Dyrk1a) + deg(complex(a(MESH:Microtubules), p(HGNC:MAPT))) regulates p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) - pmid:21427723 + pubmed:2446784 - p(HBP:"4R tau") association path(HBP:"4R tauopathy") + complex(a(MESH:Microtubules), p(HGNC:MAPT)) association p(HGNC:MAPT) - pmid:27574109 + pubmed:25031639 - p(HBP:"4R tau") positiveCorrelation p(HBP:"phosphatase-activating domain") + p(HGNC:MAPT, pmod(CONSO:misfolded), loc(GO:"dendrite terminus")) increases bp(GO:"anterograde dendritic transport") - pmid:12428809 + pubmed:25031639 - a(MESH:"Intermediate Filaments") positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") + p(HGNC:MAPT, pmod(CONSO:misfolded), loc(GO:"dendrite terminus")) increases bp(GO:"retrograde dendritic transport") - pmid:12428809 + pubmed:25031639 - a(MESH:"Intermediate Filaments") negativeCorrelation a(MESH:Axons) + p(HGNC:MAPT, pmod(CONSO:misfolded), loc(GO:"axon terminus")) increases bp(GO:"anterograde axonal transport") - pmid:12428809 + pubmed:25031639 - a(MESH:Axons) negativeCorrelation a(MESH:"Intermediate Filaments") + p(HGNC:MAPT, pmod(CONSO:misfolded), loc(GO:"axon terminus")) increases bp(GO:"retrograde axonal transport") - pmid:27671637 + pubmed:25031639 - a(MESH:Axons) positiveCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) + tloc(p(HGNC:MAPT, pmod(CONSO:misfolded)), fromLoc(GO:cytoplasm), toLoc(MESH:Neurons)) increases path(DOID:tauopathy) - pmid:12428809 + pubmed:25031639 - p(HBP:"3R tau") increases a(HBP:"straight filaments") + p(HGNC:MAPT, pmod(CONSO:misfolded), loc(MESH:Neurons)) increases path(DOID:tauopathy) - pmid:26751493 + pubmed:28877763 - p(HBP:"3R tau") positiveCorrelation path(MESH:"Niemann-Pick Diseases") + p(HGNC:MAPT, pmod(CONSO:misfolded)) positiveCorrelation act(p(HGNC:SYK)) - pmid:26631930 + pubmed:29311797 - p(HBP:"3R tau") positiveCorrelation path(MESH:"Niemann-Pick Diseases") + p(HGNC:MAPT, pmod(CONSO:misfolded)) increases bp(GO:"cell death in response to oxidative stress") - pmid:26631930 + pubmed:16566606 - p(HBP:"3R tau") positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAPT, pmod(CONSO:misfolded)) association p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 18)) - pmid:26631930 + pubmed:16566606 - p(HBP:"3R tau") directlyIncreases complex(a(GO:microtubule), p(HBP:"3R tau")) + p(HGNC:MAPT, pmod(CONSO:misfolded)) association p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) - pmid:23407988 + pubmed:16566606 - p(HBP:"3R tau") isA p(HGNC:MAPT) + p(HGNC:MAPT, pmod(CONSO:misfolded)) association p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 197)) - pmid:23407988 + pubmed:16566606 - p(HBP:"3R tau") partOf complex(GO:"neurofibrillary tangle") + p(HGNC:MAPT, pmod(CONSO:misfolded)) association p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 394)) - pmid:23407988 + pubmed:25031639 - p(HBP:"3R tau") partOf a(HBP:"ghost tangles") + bp(GO:"anterograde dendritic transport") increases tloc(p(HGNC:MAPT, pmod(CONSO:misfolded)), fromLoc(GO:cytoplasm), toLoc(MESH:Neurons)) - pmid:23407988 + pubmed:25031639 - p(HBP:"3R tau") partOf a(HBP:"Brodmann (1909) area 36") + bp(GO:"retrograde dendritic transport") increases tloc(p(HGNC:MAPT, pmod(CONSO:misfolded)), fromLoc(GO:cytoplasm), toLoc(MESH:Neurons)) - pmid:23407988 + pubmed:25031639 - p(HBP:"3R tau") partOf a(HBP:"CA1 field of hippocampus") + bp(GO:"anterograde axonal transport") increases tloc(p(HGNC:MAPT, pmod(CONSO:misfolded)), fromLoc(GO:cytoplasm), toLoc(MESH:Neurons)) - pmid:23407988 + pubmed:23516100 - p(HBP:"3R tau") partOf a(HBP:"CA2 field of hippocampus") + bp(GO:"anterograde axonal transport") negativeCorrelation p(HGNC:MAPT, frag("?"), pmod(go:0006468 ! "protein phosphorylation")) - pmid:23407988 + pubmed:25374103 - p(HBP:"3R tau") partOf a(HBP:"CA3 field of hippocampus") + bp(GO:"anterograde axonal transport") decreases a(MESH:Mitochondria) - pmid:23407988 + pubmed:25374103 - p(HBP:"3R tau") partOf a(HBP:"CA4 field of hippocampus") + bp(GO:"anterograde axonal transport") positiveCorrelation composite(p(HGNC:MAPT), p(HGNC:MARK2)) - pmid:23407988 + pubmed:25031639 - p(HBP:"3R tau") partOf complex(GO:dendrite) + bp(GO:"retrograde axonal transport") increases tloc(p(HGNC:MAPT, pmod(CONSO:misfolded)), fromLoc(GO:cytoplasm), toLoc(MESH:Neurons)) - pmid:23407988 + pubmed:30027901 - p(HBP:"3R tau") partOf a(MESH:Neuropil) + bp(GO:"retrograde axonal transport") increases tloc(a(MESH:Autophagosomes), fromLoc(GO:"distal axon"), toLoc(GO:"cell body")) - pmid:23407988 + pubmed:25031639 - p(HBP:"3R tau") partOf complex(GO:"neuronal cell body") + p(HGNC:MAPT, var("p.Pro301Ser")) increases path(DOID:tauopathy) - pmid:26655600 + pubmed:28148553 - p(HBP:"3R tau") causesNoChange a(HBP:"Tau aggregates") + p(HGNC:MAPT, var("p.Pro301Ser")) decreases p(HGNC:EIF2A, pmod(go:0006468 ! "protein phosphorylation")) - pmid:26655600 + pubmed:28148553 - p(HBP:"3R tau", loc(GO:"Pick body")) positiveCorrelation path(MESH:"Pick Disease of the Brain") + p(HGNC:MAPT, var("p.Pro301Ser")) increases p(HGNC:EIF2AK3) - pmid:28775333 + pubmed:28148553 - p(HBP:"3R tau") positiveCorrelation p(MGI:Dyrk1a) + p(HGNC:MAPT, var("p.Pro301Ser")) increases p(HGNC:EIF2AK3, pmod(go:0006468 ! "protein phosphorylation")) - pmid:12428809 + pubmed:28148553 - a(HBP:"straight filaments") association path(MESH:"Alzheimer Disease") + p(HGNC:MAPT, var("p.Pro301Ser")) increases p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation")) - - - - - pmid:29238289 + pubmed:28148553 - a(MESH:Microtubules) association p(HGNC:MAPT) + p(HGNC:MAPT, var("p.Pro301Ser")) increases path(EFO:"memory impairment") - + + + pubmed:28148553 + + p(HGNC:MAPT, var("p.Pro301Ser")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"), var("p.Pro301Ser")) + - pmid:25374103 + pubmed:28148553 - bp(GO:"anterograde axonal transport") decreases a(MESH:Mitochondria) + p(HGNC:MAPT, var("p.Pro301Ser")) negativeCorrelation path(MESH:"Protein Conformation") - pmid:25374103 + pubmed:28148553 - bp(GO:"anterograde axonal transport") positiveCorrelation composite(p(HGNC:MAPT), p(HGNC:MARK2)) + p(HGNC:MAPT, var("p.Pro301Ser")) negativeCorrelation bp(GO:"dendritic spine maintenance") - pmid:12428809 + pubmed:28148553 - p(HGNC:APPL) increases bp(GO:"anterograde axonal transport") + p(HGNC:MAPT, var("p.Pro301Ser")) negativeCorrelation path(MESH:Locomotion) - pmid:22299660 + pubmed:28148553 - a(MESH:Mitochondria) association p(FPLX:PPP2) + p(HGNC:MAPT, var("p.Pro301Ser")) increases a(CONSO:"paired helical filaments") - pmid:30126037 + pubmed:28148553 - act(a(MESH:Mitochondria)) association bp(GO:"cellular respiration") + p(HGNC:MAPT, var("p.Pro301Ser")) negativeCorrelation a(FMA:83664) @@ -100456,2962 +101286,3206 @@

Statements

- pmid:22299660 + pubmed:28148553 - a(HBP:"paired helical filaments") negativeCorrelation act(p(FPLX:PPP2)) + p(HGNC:MAPT, var("p.Pro301Ser")) negativeCorrelation a(MESH:"Motor Neurons") - pmid:14556719 + pubmed:28148553 - a(HBP:"paired helical filaments") decreases act(complex(GO:"proteasome complex")) + p(HGNC:MAPT, var("p.Pro301Ser")) negativeCorrelation a(MESH:"Spinal Cord Ventral Horn") - pmid:22908190 + pubmed:29590627 - a(HBP:"paired helical filaments") negativeCorrelation act(complex(GO:"proteasome complex")) + p(HGNC:MAPT, var("p.Pro301Ser")) increases path(MESH:"Frontotemporal Dementia") - pmid:22908190 + pubmed:29590627 - a(HBP:"paired helical filaments") association a(GO:"neurofibrillary tangle") + p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) - pmid:22908190 + pubmed:29590627 - a(HBP:"paired helical filaments") association a(HBP:"dystrophic neurite") + p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) - pmid:22908190 + pubmed:29590627 - a(HBP:"paired helical filaments") association p(HGNC:MAPT) + p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) - pmid:22908190 + pubmed:29590627 - a(HBP:"paired helical filaments") association p(HGNC:MAPT) + p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) - pmid:22908190 + pubmed:29590627 - a(HBP:"paired helical filaments") association a(MESH:Ubiquitin) + p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) - pmid:22908190 + pubmed:29590627 - a(HBP:"paired helical filaments") association p(HBP:"Tau isoform F (441 aa)", pmod(Ub, Lys, 254)) + p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) - pmid:22908190 + pubmed:29590627 - a(HBP:"paired helical filaments") association p(HBP:"Tau isoform F (441 aa)", pmod(Ub, Lys, 257)) + p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) - pmid:22908190 + pubmed:29590627 - a(HBP:"paired helical filaments") association p(HBP:"Tau isoform F (441 aa)", pmod(Ub, Lys, 311)) + p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) - pmid:22908190 + pubmed:29590627 - a(HBP:"paired helical filaments") association p(HBP:"Tau isoform F (441 aa)", pmod(Ub, Lys, 317)) + p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) - pmid:22908190 + pubmed:29590627 - a(HBP:"paired helical filaments") association p(HBP:"Tau isoform F (441 aa)", pmod(UbK48)) + p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) - pmid:22908190 + pubmed:29590627 - a(HBP:"paired helical filaments") association p(HBP:"Tau isoform F (441 aa)", pmod(UbK48)) + p(HGNC:MAPT, var("p.Pro301Ser")) association a(GO:"early endosome") - pmid:22908190 + pubmed:29590627 - a(HBP:"paired helical filaments") association p(HBP:"Tau isoform F (441 aa)", pmod(UbPoly, Lys, 6)) + p(HGNC:MAPT, var("p.Pro301Ser")) association a(GO:"late endosome") - pmid:22908190 + pubmed:29590627 - a(HBP:"paired helical filaments") association p(HBP:"Tau isoform F (441 aa)", pmod(UbPoly, Lys, 11)) + p(HGNC:MAPT, var("p.Pro301Ser")) association a(GO:lysosome) - - - pmid:26631930 - - a(HBP:"paired helical filaments") association p(HGNC:MAPT, pmod(Ph, Tyr, 18)) - + - pmid:26631930 + pubmed:24406748 - a(HBP:"paired helical filaments") association p(HGNC:MAPT, pmod(Ph, Tyr, 394)) + p(HGNC:MAPT, var("p.Pro301Ser")) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) - pmid:17050703 + pubmed:24406748 - a(HBP:"paired helical filaments") association p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) + p(HGNC:MAPT, var("p.Pro301Ser")) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) - pmid:16566606 + pubmed:24406748 - a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) + p(HGNC:MAPT, var("p.Pro301Ser")) decreases path(MESH:Cognition) - pmid:16566606 + pubmed:24406748 - a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) + p(HGNC:MAPT, var("p.Pro301Ser")) increases path(CONSO:"mitochondrial dysfunction") - pmid:16566606 + pubmed:24406748 - a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) + p(HGNC:MAPT, var("p.Pro301Ser")) decreases bp(GO:"axonal transport") - pmid:16566606 + pubmed:22372633 - a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) + p(HGNC:TPPP) association act(a(MESH:Microtubules)) - pmid:16566606 + pubmed:22372633 - a(HBP:"paired helical filaments") positiveCorrelation a(HBP:"3-3 dityrosine cross-linking") + p(HGNC:TPPP) association bp(GO:"cell motility") + + - pmid:26501932 + pubmed:22372633 - a(HBP:"paired helical filaments") partOf a(HBP:pretangles) + bp(GO:"cell motility") association p(HGNC:TPPP) - pmid:7667312 + pubmed:22372633 - a(HBP:"paired helical filaments") positiveCorrelation a(HBP:"Thioflavin S") + complex(p(HGNC:HDAC6), p(HGNC:TPPP)) decreases act(p(HGNC:HDAC6), ma(GO:"deacetylase activity")) - pmid:7667312 + pubmed:22372633 - a(HBP:"paired helical filaments") partOf complex(GO:"neurofibrillary tangle") + complex(p(HGNC:HDAC6), p(HGNC:MAPT)) decreases act(p(HGNC:HDAC6), ma(GO:"deacetylase activity")) - pmid:8391280 + pubmed:29661268 - a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(Ub, Lys, 254)) + complex(p(HGNC:HDAC6), p(HGNC:MAPT)) increases act(p(HGNC:HDAC6)) - pmid:8391280 + pubmed:22372633 - a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(Ub, Lys, 257)) + p(HGNC:SIRT2) decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) - pmid:8391280 + pubmed:22372633 - a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(Ub, Lys, 311)) + bp(GO:"axonal transport of mitochondrion") negativeCorrelation p(HGNC:HDAC6) - pmid:22299660 + pubmed:30935091 - p(HGNC:MAPT, pmod(Ph, Ser, 198)) positiveCorrelation path(MESH:"Alzheimer Disease") + bp(GO:"axonal transport of mitochondrion") negativeCorrelation p(HGNC:HDAC6) - pmid:23088643 + pubmed:22372633 - p(HGNC:MAPT, pmod(Ph, Ser, 198)) positiveCorrelation path(MESH:"Alzheimer Disease") + bp(GO:"axonal transport of mitochondrion") positiveCorrelation p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) - pmid:22299660 + pubmed:22372633 - p(HGNC:MAPT, pmod(Ph, Ser, 199)) positiveCorrelation path(MESH:"Alzheimer Disease") + bp(GO:"axonal transport of mitochondrion") positiveCorrelation composite(a(MESH:Microtubules), p(MESH:Dyneins), p(MESH:Kinesin)) - pmid:26458742 + pubmed:30837838 - p(HGNC:MAPT, pmod(Ph, Ser, 199)) positiveCorrelation path(MESH:"Alzheimer Disease") + bp(GO:"axonal transport of mitochondrion") negativeCorrelation p(HGNC:TARDBP, var("?")) - pmid:23088643 + pubmed:22372633 - p(HGNC:MAPT, pmod(Ph, Ser, 199)) positiveCorrelation path(MESH:"Alzheimer Disease") + composite(a(MESH:Microtubules), p(MESH:Dyneins), p(MESH:Kinesin)) positiveCorrelation bp(GO:"axonal transport of mitochondrion") - - - pmid:20071522 - - p(HGNC:MAPT, pmod(Ph, Ser, 199)) isA p(RGD:Mapt, pmod(Ph)) - + - pmid:20071522 + pubmed:22372633 - p(HGNC:MAPT, pmod(Ph, Ser, 199)) association complex(p(HGNC:FKBP5), p(HGNC:MAPT)) + p(MESH:Dyneins) causesNoChange p(HGNC:HDAC6) - pmid:20071522 + pubmed:22372633 - p(HGNC:MAPT, pmod(Ph, Ser, 199)) positiveCorrelation p(HGNC:FKBP5) + p(MESH:Dyneins) increases bp(GO:"stress granule assembly") + + - pmid:21367866 + pubmed:22372633 - p(HGNC:MAPT, pmod(Ph, Ser, 199)) positiveCorrelation p(HGNC:CDC37) + bp(GO:"microtubule depolymerization") positiveCorrelation p(HGNC:HDAC6) - pmid:17078951 + pubmed:26323690 - p(HGNC:MAPT, pmod(Ph, Ser, 199)) positiveCorrelation p(FPLX:PKA) + bp(GO:"microtubule depolymerization") negativeCorrelation p(HGNC:KIF2A, pmod(go:0006468 ! "protein phosphorylation")) + + - pmid:23088643 + pubmed:22372633 - p(HGNC:MAPT, pmod(Ph, Ser, 199)) partOf p(HBP:"Tau epitope, AT8") + p(HGNC:MAPRE1) increases bp(MESH:Growth) + + - pmid:25331948 + pubmed:25297623 - p(HGNC:MAPT, pmod(Ph, Ser, 199)) partOf p(HBP:"Tau epitope, AT8") + p(HGNC:MAPRE1) partOf complex(p(HGNC:MAPRE1), p(HGNC:TTBK2)) - pmid:22833681 + pubmed:25297623 - p(HGNC:MAPT, pmod(Ph, Ser, 199)) partOf p(HBP:"Tau epitope, AT8") + p(HGNC:MAPRE1) association p(HGNC:TTBK2) - pmid:19459590 + pubmed:22372633 - p(HGNC:MAPT, pmod(Ph, Ser, 199)) decreases complex(a(MESH:Microtubules), p(HGNC:MAPT)) + p(HGNC:ACTR1A) increases bp(MESH:Growth) - pmid:22833681 + pubmed:22372633 - p(HGNC:MAPT, pmod(Ph, Ser, 199)) increases complex(p(HGNC:FYN), p(HGNC:MAPT)) + a(CHEBI:"growth hormone") increases p(HGNC:HDAC6, loc(GO:membrane)) - pmid:21734277 + pubmed:22372633 - p(HGNC:MAPT, pmod(Ph, Ser, 199)) positiveCorrelation p(HBP:"phosphatase-activating domain") + complex(p(HGNC:CTTN), p(HGNC:HDAC6)) decreases p(HGNC:CTTN, pmod(go:0006473 ! "protein acetylation")) - - - pmid:22299660 - - p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation path(MESH:"Alzheimer Disease") - + - pmid:29191965 + pubmed:22372633 - p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNC:CTTN), ma(GO:"actin filament binding")) association p(HGNC:CTTN, pmod(go:0006473 ! "protein acetylation")) - pmid:26751493 + pubmed:22372633 - p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:CTTN) increases bp(GO:"actin filament reorganization") - pmid:27373205 + pubmed:22372633 - p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNC:CTTN), ma(GO:"actin filament binding")) increases bp(GO:"actin filament reorganization") - pmid:23088643 + pubmed:22372633 - p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:CTTN) increases bp(GO:"actin filament organization") - pmid:26751493 + pubmed:22372633 - p(HGNC:MAPT, pmod(Ph, Ser, 422)) partOf p(HBP:"Tau aggregates") + act(p(HGNC:CTTN), ma(GO:"actin filament binding")) regulates bp(GO:"actin filament organization") - pmid:27373205 + pubmed:22372633 - p(HGNC:MAPT, pmod(Ph, Ser, 422)) association a(HBP:"Tau oligomers") + p(HGNC:CTTN, pmod(go:0006473 ! "protein acetylation")) association act(p(HGNC:CTTN), ma(GO:"actin filament binding")) - pmid:22817713 + pubmed:22372633 - p(HGNC:MAPT, pmod(Ph, Ser, 422)) association a(HBP:"Tau oligomers") + bp(GO:"actin filament reorganization") increases bp(GO:"autophagosome-lysosome fusion") - pmid:27373205 + pubmed:22372633 - p(HGNC:MAPT, pmod(Ph, Ser, 422)) association a(HBP:"Tau antibody, TNT1") + p(HGNC:PRX, pmod(go:0006473 ! "protein acetylation")) increases act(p(HGNC:PRX), ma(GO:"antioxidant activity")) + + - pmid:26631930 + pubmed:22372633 - p(HGNC:MAPT, pmod(Ph, Ser, 422)) decreases p(HGNC:MAPT, frag("?")) + p(HGNC:HSF1) increases p(HGNCGENEFAMILY:"Heat shock 90kDa proteins") - pmid:26671985 + pubmed:30837838 - p(HGNC:MAPT, pmod(Ph, Ser, 422)) biomarkerFor path(MESH:"Chronic Traumatic Encephalopathy") + p(HGNC:HSF1) increases p(HGNCGENEFAMILY:"Heat shock 90kDa proteins") - - - pmid:26671985 - - p(HGNC:MAPT, pmod(Ph, Ser, 422)) increases path(MESH:"Cognitive Dysfunction") - + - pmid:17078951 + pubmed:27491084 - p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation p(FPLX:PKA) + p(HGNC:HSF1) increases bp(CONSO:Proteostasis) - pmid:23088643 + pubmed:21882945 - p(HGNC:MAPT, pmod(Ph, Ser, 422)) partOf a(GO:"neurofibrillary tangle") + p(HGNC:HSF1) increases bp(CONSO:Proteostasis) - pmid:23088643 + pubmed:23746257 - p(HGNC:MAPT, pmod(Ph, Ser, 422)) association a(GO:"neurofibrillary tangle") + p(HGNC:HSF1) regulates bp(GO:"cellular response to stress") - pmid:23088643 + pubmed:23746257 - p(HGNC:MAPT, pmod(Ph, Ser, 422)) partOf a(MESH:"Neuropil Threads") + p(HGNC:HSF1) increases a(MESH:"Molecular Chaperones") - pmid:23088643 + pubmed:25784053 - p(HGNC:MAPT, pmod(Ph, Ser, 422)) partOf path(MESH:"Plaque, Amyloid") + act(p(HGNC:HSF1), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases a(MESH:"Molecular Chaperones") - pmid:23088643 + pubmed:23746257 - p(HGNC:MAPT, pmod(Ph, Ser, 422)) association a(HBP:pretangles) + p(HGNC:HSF1) decreases a(MESH:"Protein Aggregates") - pmid:11943212 + pubmed:25784053 - p(HGNC:MAPT, pmod(Ph, Ser, 422)) partOf p(HBP:"Tau epitope, AP422") + act(p(HGNC:HSF1)) increases tloc(p(HGNC:HSF1), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) + + + + - pmid:23294633 + pubmed:25784053 - p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) + act(p(HGNC:HSF1)) association path(MESH:Neoplasms) - pmid:27373205 + pubmed:24563850 - p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation p(HBP:"phosphatase-activating domain") + p(HGNC:HSF1) increases a(MESH:"Heat-Shock Proteins") - pmid:27373205 + pubmed:21882945 - p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation p(HBP:"Tau dimers") + p(HGNC:HSF1) increases a(MESH:"Heat-Shock Proteins") + + + + + + + + - pmid:27373205 + pubmed:30116051 - p(HGNC:MAPT, pmod(Ph, Ser, 422)) decreases bp(GO:"anterograde axonal transport") + act(p(HGNC:HSF1), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases act(p(FPLX:HSPA)) - pmid:22299660 + pubmed:30837838 - p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:HSF1) increases p(HGNCGENEFAMILY:"Heat shock 70kDa proteins") - pmid:29758300 + pubmed:30837838 - p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:HSF1) decreases p(CONSO:"TDP-43 aggregates") - pmid:26751493 + pubmed:22372633 - p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation path(MESH:"Alzheimer Disease") + complex(p(HGNC:HDAC6), p(HGNC:HSF1), p(HGNCGENEFAMILY:"Heat shock 90kDa proteins")) decreases act(p(HGNC:HSF1)) - pmid:29758300 + pubmed:30640040 - p(HGNC:MAPT, pmod(Ph, Ser, 262)) increases bp(GO:autophagy) + act(p(HGNC:FLT1)) increases a(CONSO:"Tau aggregates") - pmid:29215007 + pubmed:30640040 - p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) + act(p(HGNC:KDR)) increases a(CONSO:"Tau aggregates") - pmid:29215007 + pubmed:30640040 - p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases bp(GO:"actin filament bundle assembly") + p(HGNC:KDR) association a(PUBCHEM:11154925) - pmid:29215007 + pubmed:30640040 - p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases bp(GO:"actin filament bundle assembly") + p(HGNC:KDR) association a(PUBCHEM:11234052) - pmid:29215007 + pubmed:29844403 - p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_284"))) + p(HGNCGENEFAMILY:"Heat shock 90kDa proteins", pmod(go:0006473 ! "protein acetylation")) increases deg(p(HGNC:MAPT)) - pmid:25374103 + pubmed:29844403 - p(HGNC:MAPT, pmod(Ph, Ser, 262)) negativeCorrelation composite(p(HBP:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) + p(HGNCGENEFAMILY:"Heat shock 90kDa proteins", pmod(go:0006473 ! "protein acetylation")) decreases complex(p(HGNC:HDAC6), p(HGNCGENEFAMILY:"Heat shock 90kDa proteins")) + + + + - pmid:26631930 + pubmed:23516100 - p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + p(CONSO:"protein aggregates") increases act(p(HGNCGENEFAMILY:Caspases)) - pmid:17493042 + pubmed:30108137 - p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) + p(CONSO:"protein aggregates") association act(p(HGNC:TFEB)) - pmid:17493042 + pubmed:27181519 - p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases bp(GO:"neurofibrillary tangle assembly") + p(CONSO:"protein aggregates") association bp(GO:"cell death") - pmid:21367866 + pubmed:28669544 - p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation p(HGNC:CDC37) + deg(p(CONSO:"protein aggregates")) increases path(MESH:Phagocytosis) - pmid:11943212 + pubmed:22372633 - p(HGNC:MAPT, pmod(Ph, Ser, 262)) association p(HGNC:MARK4, pmod(Ph)) + complex(p(HGNC:HSF1), p(HGNCGENEFAMILY:"Heat shock 90kDa proteins")) increases p(MESH:Proteins, pmod(CONSO:misfolded), pmod(go:0016567 ! "protein ubiquitination")) - pmid:22692785 + pubmed:22372633 - p(HGNC:MAPT, pmod(Ph, Ser, 262)) partOf a(GO:"neurofibrillary tangle") + p(HGNC:VCP) decreases bp(GO:"protein ubiquitination") - pmid:22156579 + pubmed:24457024 - p(HGNC:MAPT, pmod(Ph, Ser, 262)) partOf p(HBP:"Tau epitope, 12E8") + p(HGNC:VCP) increases bp(GO:"protein ubiquitination") - pmid:23948915 + pubmed:22908190 - p(HGNC:MAPT, pmod(Ph, Ser, 262)) negativeCorrelation bp(GO:"apoptotic process") + act(p(HGNC:VCP)) regulates bp(GO:"ERAD pathway") - pmid:22833681 + pubmed:22908190 - p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) + act(p(HGNC:VCP)) regulates a(GO:autophagosome) - pmid:25031639 + pubmed:27181519 - p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases complex(p(HGNC:MAPT, pmod(Ph, Ser, 262)), p(HGNC:STUB1)) + p(HGNC:VCP) decreases a(GO:autophagosome) - pmid:22952452 + pubmed:24457024 - p(HGNC:MAPT, pmod(Ph, Ser, 262)) decreases complex(a(MESH:Microtubules), p(HGNC:MAPT)) + p(HGNC:VCP) increases bp(GO:"proteasomal protein catabolic process") - pmid:22952452 + pubmed:27181519 - p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation path(HBP:Neurodegeneration) + p(HGNC:VCP) decreases complex(GO:"cytoplasmic stress granule") - pmid:22299660 + pubmed:27181519 - p(FPLX:PPP2C, pmod(Me)) increases complex(p(FPLX:"PPP2R_A"), p(FPLX:"PPP2R_B"), p(FPLX:PPP2C)) + p(HGNC:VCP) increases complex(GO:"cytoplasmic stress granule", loc(GO:autophagosome)) - + + + pubmed:27181519 + + p(HGNC:VCP) increases complex(GO:"cytoplasmic stress granule", loc(GO:autophagosome)) + + + + pubmed:27181519 + + p(HGNC:VCP) increases bp(GO:autophagy) + + - pmid:22299660 + pubmed:27181519 - p(HGNC:ICMT) increases p(FPLX:PPP2C, pmod(Me)) + p(HGNC:VCP) decreases p(HGNC:TARDBP) - pmid:22299660 + pubmed:27181519 - p(HGNC:ICMT) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:VCP) increases bp(GO:"stress granule assembly") - pmid:22299660 + pubmed:30837838 - p(FPLX:PPP2C, pmod(Ph, Tyr, 307)) decreases act(p(FPLX:PPP2)) + p(HGNC:VCP) association path(MESH:"Amyotrophic Lateral Sclerosis") - pmid:22299660 + pubmed:22372633 - p(FPLX:PPP2C, pmod(Ph, Tyr, 307)) positiveCorrelation path(MESH:"Alzheimer Disease") + bp(GO:"protein ubiquitination") increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:22299660 + pubmed:14556719 - p(FPLX:PPP2C, pmod(Me, Leu, 309)) negativeCorrelation path(MESH:"Alzheimer Disease") + bp(GO:"protein ubiquitination") regulates bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:22299660 + pubmed:22372633 - p(FPLX:PPP2C, pmod(Me, Leu, 309)) decreases complex(p(FPLX:"PPP2R_A"), p(FPLX:"PPP2R_B"), p(FPLX:PPP2C)) + bp(GO:"protein ubiquitination") increases p(CONSO:"protein aggregates") - pmid:22299660 + pubmed:14556719 - p(FPLX:PPP2C, pmod(Ph)) association a(MESH:"Neurofibrillary Tangles") + bp(GO:"protein ubiquitination") increases bp(GO:"lysosomal protein catabolic process") - pmid:28083634 + pubmed:14556719 - p(HGNC:OTUB1) decreases p(HGNC:MAPT, pmod(Ub)) + bp(GO:"protein ubiquitination") increases bp(GO:"protein catabolic process in the vacuole") - pmid:28083634 + pubmed:18930136 - p(HGNC:OTUB1) increases complex(p(HGNC:MAPT), p(HGNC:OTUB1)) + bp(GO:"protein ubiquitination") regulates bp(GO:autophagy) - pmid:28083634 + pubmed:22372633 - p(HGNC:OTUB1) increases complex(p(HGNC:MAPT), p(HGNC:OTUB1)) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(MESH:Proteins)) - pmid:28083634 + pubmed:22372633 - p(HGNC:OTUB1) increases a(HBP:"Tau aggregates") + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation bp(GO:"stress granule assembly") - pmid:28083634 + pubmed:22372633 - p(HGNC:OTUB1) increases a(HBP:"Tau aggregates") + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(DOID:"neurodegenerative disease") - pmid:28083634 + pubmed:29661268 - p(HGNC:OTUB1) increases a(HBP:"Tau aggregates") + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(DOID:"Alzheimer's disease") - pmid:28083634 + pubmed:29661268 - p(HGNC:OTUB1) increases a(HBP:"Tau aggregates") + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) - pmid:28083634 + pubmed:29661268 - p(HGNC:OTUB1) negativeCorrelation a(HBP:"Tau aggregates") + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation), pmod(go:0016567 ! "protein ubiquitination")) - pmid:28083634 + pubmed:29661268 - p(HGNC:OTUB1) regulates p(HGNC:MAPT) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:MAPT)) - pmid:28083634 + pubmed:30116051 - p(HGNC:OTUB1) increases p(HGNC:MAPT) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:MAPT)) - pmid:28083634 + pubmed:23528736 - p(HGNC:OTUB1) decreases deg(p(HGNC:MAPT)) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association deg(p(HGNC:MAPT)) - pmid:28083634 + pubmed:23528736 - p(HGNC:OTUB1) regulates deg(p(HGNC:MAPT)) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") regulates deg(p(HGNC:MAPT)) - pmid:28083634 + pubmed:25374103 - p(HGNC:OTUB1) decreases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:MAPT)) - pmid:28083634 + pubmed:30515821 - p(HGNC:OTUB1) decreases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:DNM1, pmod(go:0016567 ! "protein ubiquitination"))) - pmid:28083634 + pubmed:30027901 - p(HGNC:OTUB1) increases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(MESH:Proteins, pmod(CONSO:misfolded))) - pmid:28083634 + pubmed:29758300 - p(HGNC:OTUB1) increases a(HBP:"Tau oligomers") + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(CONSO:Neurodegeneration) - pmid:28083634 + pubmed:18930136 - p(HGNC:OTUB1) increases a(HBP:"Tau oligomers") + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(CONSO:Neurodegeneration) - pmid:28083634 + pubmed:29758300 - p(HGNC:OTUB1) decreases p(HGNC:MAPT, pmod(UbK48)) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") decreases path(MESH:Tauopathies) - pmid:28083634 + pubmed:29758300 - p(HGNC:OTUB1) causesNoChange p(HGNC:MAPT, pmod(UbK63)) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association a(CONSO:"Tau aggregates") - + + + pubmed:23528736 + + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association a(CONSO:"Tau aggregates") + - pmid:22908190 + pubmed:29758300 - p(HGNC:MAPT, pmod(Ub)) positiveCorrelation path(MESH:"Alzheimer Disease") + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") causesNoChange deg(a(CONSO:"protein aggregates")) - pmid:24027553 + pubmed:14556719 - p(HGNC:MAPT, pmod(Ub)) association path(MESH:"Neurofibrillary Tangles") + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") decreases a(CONSO:"protein aggregates") - pmid:14612456 + pubmed:27181519 - p(HGNC:MAPT, pmod(Ub)) positiveCorrelation p(HGNC:UBE2D2) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") causesNoChange deg(a(CONSO:"protein aggregates")) - pmid:14612456 + pubmed:29758300 - p(HGNC:MAPT, pmod(Ub)) positiveCorrelation p(HGNC:MAPT, pmod(Ph)) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:SNCA)) - pmid:8391280 + pubmed:18930136 - p(HGNC:MAPT, pmod(Ub)) increases deg(p(HGNC:MAPT)) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:SNCA)) - pmid:25378699 + pubmed:18930136 - p(HGNC:MAPT, pmod(Ub)) increases deg(p(HGNC:MAPT)) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:SNCA)) - pmid:24905733 + pubmed:14556719 - p(HGNC:MAPT, pmod(Ub)) decreases complex(a(MESH:Microtubules), p(HGNC:MAPT)) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(MESH:"Parkinson Disease") - + + + pubmed:14556719 + + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:PARK7)) + - pmid:28083634 + pubmed:14556719 - complex(p(HGNC:MAPT), p(HGNC:OTUB1)) increases p(HGNC:MAPT, pmod(Ph)) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:28083634 + pubmed:23528736 - complex(p(HGNC:MAPT), p(HGNC:OTUB1)) increases a(HBP:"Tau aggregates") + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:28083634 + pubmed:14556719 - p(HGNC:USP5) decreases p(HGNC:MAPT, pmod(Ub)) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(MESH:"Prion Diseases") - pmid:28083634 + pubmed:14556719 - p(HGNC:USP5) increases complex(p(HGNC:MAPT), p(HGNC:USP5)) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(MESH:"Prion Diseases") - pmid:28083634 + pubmed:14556719 - p(HGNC:USP5) causesNoChange a(HBP:"Tau aggregates") + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation bp(GO:aging) - + + + pubmed:14556719 + + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") decreases p(HGNC:PRNP, loc(MESH:Cytoplasm)) + - pmid:28083634 + pubmed:14556719 - p(HGNC:USP9X) decreases p(HGNC:MAPT, pmod(Ub)) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:PRNP)) - pmid:28083634 + pubmed:14556719 - p(HGNC:USP9X) increases complex(p(HGNC:MAPT), p(HGNC:USP9X)) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:SOD1, var("?"))) - pmid:28083634 + pubmed:14556719 - p(HGNC:USP9X) causesNoChange a(HBP:"Tau aggregates") + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:SOD1, var("?"))) + + + pubmed:14556719 + + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:SOD1, var("?"))) + + + + + pubmed:14556719 + + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:HTT, frag("?"))) + + - pmid:28083634 + pubmed:22908190 - p(HGNC:OTUB1, var("p.Cys91Ala")) causesNoChange p(HGNC:MAPT, pmod(UbK48)) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination"))) - pmid:28083634 + pubmed:22908190 - p(HGNC:OTUB1, var("p.Cys91Ala")) causesNoChange deg(p(HGNC:MAPT)) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association bp(GO:"regulation of synaptic plasticity") - pmid:28083634 + pubmed:30116051 - p(HGNC:OTUB1, var("p.Cys91Ala")) causesNoChange p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:"regulation of synaptic plasticity") - pmid:28083634 + pubmed:22908190 - p(HGNC:OTUB1, frag("?")) decreases p(HGNC:MAPT, pmod(UbK48)) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association bp(GO:learning) - pmid:28083634 + pubmed:22908190 - p(HGNC:OTUB1, frag("?")) increases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association bp(GO:memory) - pmid:28083634 + pubmed:30116051 - p(MGI:Otub1) increases p(MGI:Mapt, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:memory) - pmid:28083634 + pubmed:22908190 - p(MGI:Otub1) increases p(MGI:Mapt, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:ARC)) - pmid:28083634 + pubmed:22908190 - p(MGI:Otub1) increases p(MGI:Mapt, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:"long-term memory") - pmid:28083634 + pubmed:18930136 - p(MGI:Otub1) increases p(MGI:Mapt) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") regulates bp(GO:"amino acid homeostasis") - pmid:28083634 + pubmed:18930136 - p(MGI:Otub1) increases a(HBP:"Tau oligomers") + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:"cellular protein catabolic process") - pmid:28083634 + pubmed:29626319 - p(MGI:Otub1) increases a(HBP:"Tau oligomers") + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:"cellular protein catabolic process") - pmid:28083634 + pubmed:18930136 - p(MGI:Otub1) increases a(HBP:"Tau oligomers") + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases rxn(reactants(a(MESH:Proteins)), products(a(CHEBI:oligopeptide))) + + + pubmed:18930136 + + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:"ubiquitin recycling") + + + + + pubmed:18930136 + + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation bp(GO:autophagy) + + - pmid:28083634 + pubmed:18930136 - p(MGI:Otub1, var("p.Cys91Ala")) causesNoChange p(MGI:Mapt, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") decreases tloc(p(HGNC:WDFY3), fromLoc(GO:nucleus), toLoc(GO:cytoplasm)) - pmid:28083634 + pubmed:30116051 - p(MGI:Otub1, var("p.Cys91Ala")) causesNoChange a(HBP:"Tau oligomers") + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:"dendrite development") - pmid:28083634 + pubmed:23528736 - p(MGI:Otub1, frag("?")) increases p(MGI:Mapt, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association path(HP:Neurodegeneration) - pmid:30012004 + pubmed:29626319 - path(MESH:Atrophy) positiveCorrelation path(MESH:"Huntington Disease") + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") regulates deg(a(MESH:Proteins)) - pmid:26195256 + pubmed:29626319 - path(MESH:Atrophy) positiveCorrelation path(MESH:"Alzheimer Disease") + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases act(p(HGNC:UBA1)) - pmid:30012004 + pubmed:29626319 - bp(GO:"dopamine metabolic process") negativeCorrelation path(MESH:"Huntington Disease") + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases act(p(FPLX:UBE2)) - pmid:30012004 + pubmed:29626319 - bp(GO:"D-glutamate metabolic process") negativeCorrelation path(MESH:"Huntington Disease") + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases act(p(MESH:"Ubiquitin-Protein Ligases")) - pmid:30012004 + pubmed:29626319 - bp(GO:"cannabinoid biosynthetic process") negativeCorrelation path(MESH:"Huntington Disease") + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases act(p(HGNC:PSMD7)) - pmid:30012004 + pubmed:29626319 - bp(GO:"adenosine catabolic process") negativeCorrelation path(MESH:"Huntington Disease") + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(a(CHEBI:amyloid-beta)) - pmid:30012004 + pubmed:29626319 - a(MESH:"Gray Matter") negativeCorrelation path(MESH:"Huntington Disease") + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(a(CHEBI:amyloid-beta)) - pmid:30012004 + pubmed:29626319 - bp(GO:"psychomotor behavior") negativeCorrelation path(MESH:"Huntington Disease") + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") decreases p(CONSO:"Tau oligomers", pmod(CONSO:hyperphosphorylation)) - pmid:30012004 + pubmed:27708431 - bp(GO:"sensory perception") negativeCorrelation path(MESH:"Huntington Disease") + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:MARK4)) - pmid:30012004 + pubmed:27181519 - bp(GO:"visual learning") negativeCorrelation path(MESH:"Huntington Disease") + bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") causesNoChange bp(GO:"ribonucleoprotein complex disassembly") - pmid:29687724 + pubmed:22372633 - path(MESH:Cognition) association path(MESH:"Huntington Disease") + complex(p(HGNC:HDAC6), p(MESH:Dyneins)) increases complex(a(MESH:Dyneins), p(CONSO:"protein aggregates")) + + - pmid:29687724 + pubmed:18930136 - path(MESH:Dystonia) association path(MESH:"Huntington Disease") + a(MESH:Dyneins) increases bp(GO:"autophagosome-lysosome fusion") - pmid:29687724 + pubmed:26631930 - path(MESH:Dystonia) association path(MESH:"Neural Pathways") + act(a(MESH:Dyneins)) association p(HGNC:MAPT) + + + + - pmid:29687724 + pubmed:30061532 - path(MESH:Dystonia) association a(CHEBI:dopamine) + p(HGNC:MAP1LC3A) increases bp(GO:"autophagosome assembly") - pmid:29687724 + pubmed:30061532 - path(MESH:"Neural Pathways") association path(MESH:Chorea) + p(HGNC:MAP1LC3A) increases bp(GO:"autophagosome maturation") - pmid:29687724 + pubmed:30027901 - path(MESH:"Neural Pathways") association path(MESH:Dystonia) + p(HGNC:MAP1LC3A) increases bp(GO:autophagy) - pmid:29687724 + pubmed:30027901 - path(MESH:"Neural Pathways") association path(MESH:"Huntington Disease") + p(HGNC:MAP1LC3A) increases a(MESH:Autophagosomes) + + - pmid:29687724 + pubmed:24027553 - a(CHEBI:risperidone) decreases a(CHEBI:dopamine) + p(HGNC:MAP1LC3A) association path(MESH:"Plaque, Amyloid") - pmid:29687724 + pubmed:27181519 - a(CHEBI:risperidone) decreases path(MESH:Chorea) + p(HGNC:MAP1LC3A) increases a(GO:phagophore) - pmid:29687724 + pubmed:27181519 - a(CHEBI:risperidone) decreases path(MESH:Dystonia) + act(p(HGNC:MAP1LC3A)) positiveCorrelation g(HGNC:C9orf72) + + - pmid:29687724 + pubmed:30837838 - a(CHEBI:risperidone) decreases path(MESH:"Stereotypic Movement Disorder") + p(HGNC:MAP1LC3A, loc(GO:"inclusion body")) association path(MESH:Autophagy) - pmid:29687724 + pubmed:30837838 - a(CHEBI:olanzapine) decreases a(CHEBI:dopamine) + p(HGNC:MAP1LC3A, loc(GO:"inclusion body")) association path(MESH:"Amyotrophic Lateral Sclerosis") - pmid:29687724 + pubmed:30837838 - a(CHEBI:olanzapine) decreases path(MESH:Chorea) + p(HGNC:MAP1LC3A, loc(GO:"inclusion body")) association path(MESH:"Frontotemporal Lobar Degeneration") + + - pmid:29687724 + pubmed:26968346 - a(CHEBI:olanzapine) decreases path(MESH:Dystonia) + bp(GO:"autophagosome-lysosome fusion") positiveCorrelation p(HGNC:TFEB) - pmid:29687724 + pubmed:26968346 - a(PUBCHEM:73437646) isA a(PUBCHEM:6018) + bp(GO:"autophagosome-lysosome fusion") positiveCorrelation p(HGNC:PSEN1) - pmid:29687724 + pubmed:26968346 - a(PUBCHEM:73437646) decreases path(MESH:Chorea) + bp(GO:"autophagosome-lysosome fusion") positiveCorrelation p(HGNC:PSEN2) - pmid:29687724 + pubmed:18930136 - path(MESH:"Motor Disorders") association path(MESH:"Huntington Disease") + bp(GO:"autophagosome-lysosome fusion") increases bp(GO:"protein catabolic process") - pmid:29687724 + pubmed:18930136 - path(MESH:"Schizophrenia, Disorganized") association path(MESH:"Huntington Disease") + bp(GO:"autophagosome-lysosome fusion") increases bp(GO:autophagy) - pmid:29687724 + pubmed:27181519 - path(MESH:"Schizophrenia, Disorganized") decreases path(MESH:Movement) + bp(GO:"autophagosome-lysosome fusion") increases a(GO:autolysosome) - pmid:29687724 + pubmed:27181519 - a(CHEBI:valproate) decreases path(MESH:"Irritable Mood") + bp(GO:"autophagosome-lysosome fusion") increases a(GO:autolysosome) - pmid:29687724 + pubmed:22372633 - a(CHEBI:valproate) decreases path(MESH:Aggression) + bp(GO:"autophagosome maturation") positiveCorrelation p(HGNC:HDAC6) - pmid:29687724 + pubmed:22372633 - a(CHEBI:carbamazepine) decreases path(MESH:"Irritable Mood") + bp(GO:"stress granule assembly") negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:29687724 + pubmed:22372633 - a(CHEBI:carbamazepine) decreases path(MESH:Aggression) + bp(GO:"stress granule assembly") negativeCorrelation bp(GO:autophagy) - pmid:29687724 + pubmed:22372633 - a(MESH:"Serotonin Uptake Inhibitors") decreases path(MESH:"Irritable Mood") + bp(GO:"stress granule assembly") increases p(HGNC:G3BP1) - pmid:29687724 + pubmed:27181519 - a(MESH:"Serotonin Uptake Inhibitors") decreases path(MESH:Aggression) + bp(GO:"stress granule assembly") negativeCorrelation p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination")) + + - pmid:29687724 + pubmed:26631930 - a(MESH:"Serotonin Uptake Inhibitors") decreases path(MESH:"Obsessive-Compulsive Disorder") + p(HGNC:G3BP1) increases complex(GO:"ribonucleoprotein granule") - pmid:29687724 + pubmed:27181519 - a(CHEBI:clomipramine) decreases path(MESH:"Obsessive-Compulsive Disorder") + p(HGNC:G3BP1) association complex(GO:"cytoplasmic stress granule") - pmid:26195256 + pubmed:22372633 - path(MESH:Thinking) decreases path(MESH:"Alzheimer Disease") + composite(p(HGNC:G3BP1), p(HGNC:HDAC6)) increases bp(GO:"stress granule assembly") - pmid:29687724 + pubmed:22372633 - a(CHEBI:amantadine) decreases a(PUBCHEM:33032) + p(HGNC:TARDBP) increases r(HGNC:HDAC6) + + + + - pmid:29687724 + pubmed:30935091 - a(CHEBI:amantadine) association path(MESH:"Huntington Disease") + p(HGNC:TARDBP) association path(DOID:"amyotrophic lateral sclerosis") - pmid:29687724 + pubmed:23384725 - a(CHEBI:amantadine) decreases p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits") + p(HGNC:TARDBP) association path(DOID:"amyotrophic lateral sclerosis") - pmid:29687724 + pubmed:30935091 - a(PUBCHEM:9795739) decreases a(CHEBI:dopamine) + p(HGNC:TARDBP) regulates act(p(HGNC:HDAC6)) + + - pmid:29687724 + pubmed:30061532 - a(PUBCHEM:9795739) association path(MESH:"Huntington Disease") + p(HGNC:TARDBP, loc(GO:"inclusion body")) association path(MESH:"Frontotemporal Lobar Degeneration") - pmid:29687724 + pubmed:30061532 - a(PUBCHEM:9795739) causesNoChange bp(GO:"motor behavior") + p(HGNC:TARDBP, loc(CONSO:"dystrophic neurite")) association path(MESH:"Frontotemporal Lobar Degeneration") - pmid:21722302 + pubmed:21722302 - path(MESH:"Prion Diseases") association path(HBP:Neurodegeneration) + p(HGNC:TARDBP) association path(MESH:"Frontotemporal Lobar Degeneration") - pmid:14556719 + pubmed:30837838 - path(MESH:"Prion Diseases") increases path(MESH:"Motor Disorders") + act(p(HGNC:TARDBP, loc(GO:nucleus))) negativeCorrelation path(MESH:"Frontotemporal Lobar Degeneration") + + + + + + + + + + + + - pmid:14556719 + pubmed:23516100 - path(MESH:"Prion Diseases") increases path(MESH:Dementia) + act(p(HGNC:TARDBP)) negativeCorrelation p(HGNC:TARDBP, pmod(CONSO:deamidation)) - pmid:14556719 + pubmed:30688256 - path(MESH:"Prion Diseases") increases path(MESH:Death) + p(HGNC:TARDBP) increases path(MESH:"Oxidative Stress") - pmid:14556719 + pubmed:30837838 - path(MESH:"Prion Diseases") increases bp(GO:"neuron death") + p(HGNC:TARDBP) increases path(MESH:"Oxidative Stress") - pmid:14556719 + pubmed:30688256 - path(MESH:"Prion Diseases") increases path(MESH:Gliosis) + p(HGNC:TARDBP) increases path(MESH:"Mitochondrial Diseases") - pmid:14556719 + pubmed:30688256 - path(MESH:"Prion Diseases") increases a(HBP:"amyloid-beta aggregates") + p(HGNC:TARDBP) increases bp(GO:mitophagy) - pmid:14556719 + pubmed:21722302 - path(MESH:"Prion Diseases") negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + p(HGNC:TARDBP) association path(MESH:"Amyotrophic Lateral Sclerosis") - pmid:14556719 + pubmed:30837838 - path(MESH:"Prion Diseases") negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + act(p(HGNC:TARDBP, loc(GO:nucleus))) negativeCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + - pmid:29980653 + pubmed:29334120 - path(MESH:"Prion Diseases") isA path(MESH:"Neurodegenerative Diseases") + act(p(HGNC:TARDBP)) increases p(CONSO:"4R tau") + + + + + + + + + + + + - pmid:29980653 + pubmed:18305152 - path(MESH:"Prion Diseases") positiveCorrelation p(HGNC:PRNP, var("?")) + act(p(HGNC:TARDBP), ma(GO:"GU repeat RNA binding")) increases composite(p(HGNC:CFTR), p(HGNC:TARDBP)) + + - pmid:27181519 + pubmed:18305152 - path(MESH:"Prion Diseases") association p(MESH:Proteins, pmod(HBP:misfolded)) + act(p(HGNC:TARDBP), ma(GO:"GU repeat RNA binding")) increases composite(p(HGNC:APOA2), p(HGNC:TARDBP)) - pmid:27181519 + pubmed:18305152 - path(MESH:"Prion Diseases") increases p(MESH:Proteins, pmod(HBP:misfolded)) + act(p(HGNC:TARDBP), ma(GO:"GU repeat RNA binding")) decreases complex(GO:"exon-exon junction complex") - pmid:21722302 + pubmed:18305152 - bp(MESH:"Endoplasmic Reticulum Stress") increases path(HBP:Neurodegeneration) + act(p(HGNC:TARDBP), ma(GO:"GU repeat RNA binding")) decreases bp(GO:"RNA splicing") - pmid:21722302 + pubmed:27181519 - bp(MESH:"Endoplasmic Reticulum Stress") association p(MESH:Proteins, pmod(HBP:misfolded)) + p(HGNC:TARDBP) association bp(GO:"RNA splicing") - pmid:21722302 + pubmed:18305152 - bp(MESH:"Endoplasmic Reticulum Stress") increases bp(MESH:"Unfolded Protein Response") + act(p(HGNC:TARDBP), ma(GO:"core promoter binding")) regulates bp(GO:"viral transcription") - pmid:21722302 + pubmed:18305152 - bp(MESH:"Endoplasmic Reticulum Stress") increases p(HGNC:ERN1) + p(HGNC:TARDBP) increases p(MESH:"Inclusion Bodies", pmod(go:0016567 ! "protein ubiquitination")) - pmid:21722302 + pubmed:18305152 - bp(MESH:"Endoplasmic Reticulum Stress") increases p(MESH:"PERK kinase") + p(HGNC:TARDBP) regulates bp(MESH:"Cell Proliferation") - pmid:21722302 + pubmed:18305152 - bp(MESH:"Endoplasmic Reticulum Stress") increases p(HGNC:ATF6) + p(HGNC:TARDBP) regulates r(HGNC:CDK6) - pmid:21722302 + pubmed:18305152 - bp(MESH:"Endoplasmic Reticulum Stress") increases tloc(p(HGNC:ATF6), fromLoc(GO:"endoplasmic reticulum membrane"), toLoc(GO:"Golgi apparatus")) + p(HGNC:TARDBP) regulates r(HGNC:POLD4) - pmid:25784053 + pubmed:18305152 - bp(MESH:"Endoplasmic Reticulum Stress") increases tloc(p(HGNC:ATF6), fromLoc(MESH:"Endoplasmic Reticulum"), toLoc(MESH:"Golgi Apparatus")) + p(HGNC:TARDBP) regulates r(HGNC:CCNB1) - pmid:21722302 + pubmed:18305152 - bp(MESH:"Endoplasmic Reticulum Stress") increases p(HGNC:ERN1, pmod(Ph)) + p(HGNC:TARDBP) regulates r(HGNC:CDK2) - pmid:21722302 + pubmed:18305152 - bp(MESH:"Endoplasmic Reticulum Stress") decreases complex(p(HGNC:ATF6), p(MESH:"molecular chaperone GRP78")) + p(HGNC:TARDBP) regulates r(HGNC:UBE2C) - pmid:21722302 + pubmed:18305152 - bp(MESH:"Endoplasmic Reticulum Stress") increases p(HGNC:CASP4) + p(HGNC:TARDBP) regulates r(HGNC:SKP2) - pmid:21722302 + pubmed:18305152 - bp(MESH:"Endoplasmic Reticulum Stress") increases p(HGNC:CASP2) + p(HGNC:TARDBP) directlyDecreases p(HGNC:CDK6) - pmid:21722302 + pubmed:18305152 - bp(MESH:"Endoplasmic Reticulum Stress") association p(HGNC:BCL2) + p(HGNC:TARDBP) directlyDecreases p(HGNC:CDK6) - pmid:21722302 + pubmed:18305152 - bp(MESH:"Endoplasmic Reticulum Stress") decreases p(HGNC:BCL2) + p(HGNC:TARDBP) directlyDecreases p(HGNC:CDK6) - pmid:21722302 + pubmed:18305152 - bp(MESH:"Endoplasmic Reticulum Stress") increases complex(GO:"BIM-BCL-2 complex") + p(HGNC:TARDBP) causesNoChange p(HGNC:CDK6) - pmid:21722302 + pubmed:18305152 - bp(MESH:"Endoplasmic Reticulum Stress") increases complex(GO:"PUMA-BCL-2 complex") + p(HGNC:TARDBP) directlyDecreases g(HGNC:CDK6) - pmid:21722302 + pubmed:18305152 - bp(MESH:"Endoplasmic Reticulum Stress") increases complex(GO:"NOXA-BCL-2 complex") + p(HGNC:TARDBP) directlyDecreases p(HGNC:RB1, pmod(go:0006468 ! "protein phosphorylation")) - pmid:21722302 + pubmed:18305152 - bp(MESH:"Endoplasmic Reticulum Stress") increases complex(GO:"CHOP-C/EBP complex") + p(HGNC:TARDBP) causesNoChange p(HGNC:RB1, pmod(go:0006468 ! "protein phosphorylation")) - pmid:21722302 + pubmed:18305152 - bp(MESH:"Endoplasmic Reticulum Stress") increases act(p(HGNC:PRKAA1)) + p(HGNC:TARDBP) directlyDecreases p(HGNC:RBL2, pmod(go:0006468 ! "protein phosphorylation")) - pmid:21722302 + pubmed:18305152 - bp(MESH:"Endoplasmic Reticulum Stress") increases tloc(a(CHEBI:"calcium cation"), fromLoc(GO:"endoplasmic reticulum"), toLoc(GO:cytoplasm)) + p(HGNC:TARDBP) causesNoChange p(HGNC:RBL2, pmod(go:0006468 ! "protein phosphorylation")) - pmid:21722302 + pubmed:18305152 - bp(MESH:"Endoplasmic Reticulum Stress") increases bp(GO:autophagy) + p(HGNC:TARDBP) directlyDecreases p(HGNC:RB1) - pmid:21722302 + pubmed:18305152 - bp(MESH:"Endoplasmic Reticulum Stress") association path(MESH:"Neurodegenerative Diseases") + p(HGNC:TARDBP) regulates bp(GO:"cell cycle") - pmid:21722302 + pubmed:18305152 - bp(MESH:"Endoplasmic Reticulum Stress") association r(MESH:"molecular chaperone GRP78") + p(HGNC:TARDBP) positiveCorrelation bp(GO:"G0 to G1 transition") - pmid:21722302 + pubmed:18305152 - bp(MESH:"Endoplasmic Reticulum Stress") increases p(HGNC:ATF4) + p(HGNC:TARDBP) negativeCorrelation bp(GO:"cell cycle G1/S phase transition") - pmid:25784053 + pubmed:18305152 - bp(MESH:"Endoplasmic Reticulum Stress") increases act(p(HGNC:EIF2AK3), ma(kin)) + p(HGNC:TARDBP) negativeCorrelation bp(GO:"cell cycle G2/M phase transition") - pmid:21722302 + pubmed:18305152 - bp(MESH:"Unfolded Protein Response") decreases bp(GO:translation) + p(HGNC:TARDBP) negativeCorrelation bp(GO:"cell death") - pmid:21722302 + pubmed:28669544 - bp(MESH:"Unfolded Protein Response") decreases bp(GO:"mRNA transcription") + p(HGNC:TARDBP, loc(GO:nucleus)) decreases bp(GO:"cell death") - pmid:21722302 + pubmed:28669544 - bp(MESH:"Unfolded Protein Response") increases bp(GO:"protein folding") + act(p(HGNC:TARDBP)) directlyIncreases bp(GO:"cell death") - pmid:21722302 + pubmed:28669544 - bp(MESH:"Unfolded Protein Response") increases p(MESH:"Molecular Chaperones") + act(p(HGNC:TARDBP)) decreases bp(GO:"cell death") - pmid:21722302 + pubmed:18305152 - bp(MESH:"Unfolded Protein Response") increases deg(p(MESH:Proteins, pmod(HBP:misfolded))) + p(HGNC:TARDBP) negativeCorrelation path(MESH:"Cell Nucleus Shape") - pmid:21722302 + pubmed:18305152 - bp(MESH:"Unfolded Protein Response") increases act(p(HGNC:ATF6)) + p(HGNC:TARDBP) causesNoChange path(MESH:"Cell Nucleus Shape") - pmid:21722302 + pubmed:18305152 - bp(MESH:"Unfolded Protein Response") increases act(p(HGNC:ATF4)) + p(HGNC:TARDBP) regulates p(HGNC:EMD, loc(GO:"nuclear envelope")) - pmid:21722302 + pubmed:18305152 - bp(MESH:"Unfolded Protein Response") increases act(p(HGNC:ATF3)) + p(HGNC:TARDBP) decreases bp(GO:"meiotic DNA double-strand break formation") - pmid:21722302 + pubmed:18305152 - bp(MESH:"Unfolded Protein Response") increases act(p(MESH:"Nrf2a protein, zebrafish")) + p(HGNC:TARDBP) decreases p(NCBIGENE:3014, pmod(go:0006468 ! "protein phosphorylation")) - pmid:21722302 + pubmed:18305152 - bp(MESH:"Unfolded Protein Response") increases act(p(HGNC:XBP1)) + p(HGNC:TARDBP) decreases path(MESH:"DNA Fragmentation") - pmid:21722302 + pubmed:18305152 - bp(MESH:"Unfolded Protein Response") increases bp(GO:"apoptotic signaling pathway") + p(HGNC:TARDBP) decreases bp(GO:"nucleolar fragmentation") - pmid:21722302 + pubmed:18305152 - bp(MESH:"Unfolded Protein Response") increases complex(GO:"CHOP-C/EBP complex") + p(HGNC:TARDBP) decreases p(HGNC:PARP1, frag("?")) - pmid:21722302 + pubmed:18305152 - bp(MESH:"Unfolded Protein Response") increases complex(GO:"CHOP-C/EBP complex") + p(HGNC:TARDBP) decreases bp(GO:"induction of programmed cell death") - pmid:21722302 + pubmed:18305152 - bp(MESH:"Unfolded Protein Response") increases bp(GO:autophagy) + p(HGNC:TARDBP) causesNoChange bp(GO:"programmed cell death") - pmid:21722302 + pubmed:18305152 - bp(MESH:"Unfolded Protein Response") increases bp(GO:autophagy) + p(HGNC:TARDBP) negativeCorrelation bp(GO:"programmed cell death") - pmid:21722302 + pubmed:18305152 - bp(MESH:"Unfolded Protein Response") increases p(MESH:"molecular chaperone GRP78") + p(HGNC:TARDBP) negativeCorrelation bp(GO:"programmed cell death") - pmid:21722302 + pubmed:18305152 - bp(MESH:"Unfolded Protein Response") increases p(HGNC:EIF2A, pmod(Ph)) + p(HGNC:TARDBP) negativeCorrelation path(NCIT:C17768) - pmid:21722302 + pubmed:18305152 - bp(MESH:"Unfolded Protein Response") increases bp(MESH:Apoptosis) + p(HGNC:TARDBP) negativeCorrelation path(NCIT:C91663) - pmid:21722302 + pubmed:23384725 - bp(MESH:"Unfolded Protein Response") increases bp(MESH:Apoptosis) + act(p(HGNC:TARDBP), ma(MESH:"Repressor Proteins")) decreases a(MESH:"DNA, Viral") - pmid:21722302 + pubmed:23384725 - bp(MESH:"Unfolded Protein Response") increases bp(MESH:Apoptosis) + p(HGNC:TARDBP) regulates bp(GO:"mRNA transcription") - pmid:21722302 + pubmed:23384725 - bp(MESH:"Unfolded Protein Response") increases bp(GO:mitophagy) + p(HGNC:TARDBP) regulates bp(GO:"RNA processing") - pmid:21722302 + pubmed:23384725 - bp(MESH:"Unfolded Protein Response") association a(MESH:"Superoxide Dismutase-1") + p(HGNC:TARDBP) association bp(GO:"synaptic signaling") - pmid:21722302 + pubmed:23384725 - bp(MESH:"Unfolded Protein Response") association p(HGNC:VAPB) + p(HGNC:TARDBP) association bp(NCIT:C19375) - pmid:21722302 + pubmed:23384725 - bp(MESH:"Unfolded Protein Response") association path(MESH:"Neurodegenerative Diseases") + p(HGNC:TARDBP) association path(OMIT:0026893) + + + + + + + + + + + + + + + + - pmid:25784053 + pubmed:27181519 - bp(GO:"protein folding") association bp(HBP:Proteostasis) + p(HGNC:TARDBP) regulates bp(GO:autophagy) - pmid:29311797 + pubmed:27181519 - bp(GO:"protein folding") association a(MESH:"Molecular Chaperones") + p(HGNC:TARDBP) regulates bp(GO:"lysosome organization") - pmid:21722302 + pubmed:27181519 - p(MESH:"Molecular Chaperones") increases bp(GO:"protein folding") + p(HGNC:TARDBP) regulates bp(GO:"autophagosome assembly") - pmid:21722302 + pubmed:26702100 - p(MESH:"Molecular Chaperones") increases bp(GO:"protein folding") + p(HGNC:TARDBP) decreases bp(GO:"autophagosome assembly") + + - pmid:25784053 + pubmed:27181519 - act(p(HGNC:ERN1), ma(kin)) increases p(HGNC:ERN1, pmod(Ph)) + act(p(HGNC:TARDBP)) negativeCorrelation path(MESH:"Motor Neuron Disease") - pmid:21722302 + pubmed:30837838 - p(HGNC:ERN1) regulates bp(GO:autophagy) + p(HGNC:TARDBP) association path(MESH:"Motor Neuron Disease") - pmid:21722302 + pubmed:27181519 - p(HGNC:ERN1) increases bp(GO:"JNK cascade") + p(HGNC:TARDBP) regulates bp(MESH:"Transcription, Genetic") - pmid:21722302 + pubmed:27181519 - p(HGNC:ERN1) association p(PFAM:Presenilin) + p(HGNC:TARDBP, loc(GO:cytosol)) association complex(GO:"cytoplasmic stress granule") - pmid:21722302 + pubmed:30837838 - p(HGNC:ERN1) regulates p(HGNC:XBP1) + p(HGNC:TARDBP) association complex(GO:"cytoplasmic stress granule") - pmid:25784053 + pubmed:30837838 - act(p(HGNC:ERN1), ma(GO:"ribonuclease activity")) increases p(HGNC:XBP1) + p(HGNC:TARDBP) regulates complex(GO:"cytoplasmic stress granule") - pmid:21722302 + pubmed:27181519 - p(HGNC:ERN1) association p(HGNC:VAPB) + act(p(HGNC:TARDBP)) regulates a(CHEBI:"nucleic acid") - pmid:21722302 + pubmed:27181519 - p(HGNC:ERN1) association path(MESH:"Amyotrophic Lateral Sclerosis") + p(HGNC:TARDBP) decreases bp(GO:"motor behavior") - pmid:21722302 + pubmed:27181519 - p(MESH:"PERK kinase") increases p(HGNC:EIF2A, pmod(Ph, Ser, 51)) + p(HGNC:TARDBP) decreases bp(GO:locomotion) - pmid:21722302 + pubmed:28669544 - p(MESH:"PERK kinase") decreases complex(p(HGNC:KEAP1), p(MESH:"Nrf2a protein, zebrafish")) + p(HGNC:TARDBP) directlyIncreases deg(p(MESH:"Amyloid beta-Peptides")) - pmid:21722302 + pubmed:28669544 - p(MESH:"PERK kinase") increases p(MESH:"Nrf2a protein, zebrafish", pmod(Ph), loc(MESH:"Cell Nucleus")) + p(HGNC:TARDBP) isA p(MESH:"RNA-Binding Proteins") - pmid:21722302 + pubmed:28669544 - p(MESH:"PERK kinase") regulates bp(GO:autophagy) + p(HGNC:TARDBP) isA p(MESH:"DNA-Binding Proteins") - pmid:21722302 + pubmed:28669544 - p(MESH:"PERK kinase") increases bp(GO:autophagy) + p(HGNC:TARDBP) isA p(MESH:"Repressor Proteins") - pmid:21722302 + pubmed:28669544 - p(MESH:"PERK kinase") increases p(HGNC:ATG12) + p(HGNC:TARDBP) increases act(p(HGNC:TARDBP), ma(GO:"mRNA binding")) - pmid:21722302 + pubmed:30837838 - p(MESH:"PERK kinase") increases complex(GO:"CHOP-C/EBP complex") + p(HGNC:TARDBP, loc(GO:cytoplasm)) decreases act(p(HGNC:TARDBP)) - pmid:21722302 + pubmed:30837838 - p(MESH:"PERK kinase") increases p(HGNC:ATF4) + p(HGNC:TARDBP, loc(GO:"inclusion body")) decreases act(p(HGNC:TARDBP), ma(MESH:"RNA Transport")) - pmid:21722302 + pubmed:30837838 - p(MESH:"PERK kinase") association p(PFAM:Presenilin) + p(HGNC:TARDBP) increases p(HGNC:TARDBP, loc(GO:"inclusion body")) + + + pubmed:26091809 + + p(HGNC:TARDBP) increases p(HGNC:TARDBP, loc(GO:"glial cytoplasmic inclusion")) + + - pmid:21722302 + pubmed:26091809 - p(MESH:"PERK kinase") association path(MESH:"Amyotrophic Lateral Sclerosis") + p(HGNC:TARDBP) increases p(HGNC:TARDBP, loc(GO:"inclusion body")) - pmid:21722302 + pubmed:26091809 - p(HGNC:ATF6) increases a(MESH:"Molecular Chaperones") + p(HGNC:TARDBP) increases p(HGNC:TARDBP, loc(GO:"glial cytoplasmic inclusion")) - pmid:21722302 + pubmed:26091809 - p(HGNC:ATF6) increases a(MESH:"Molecular Chaperones") + p(HGNC:TARDBP) increases p(HGNC:TARDBP, loc(GO:"inclusion body")) - pmid:21722302 + pubmed:26091809 - p(HGNC:ATF6) increases bp(GO:"ERAD pathway") + p(HGNC:TARDBP) increases p(HGNC:TARDBP, loc(GO:"inclusion body")) - pmid:21722302 + pubmed:26091809 - p(HGNC:ATF6) association p(HGNC:VAPB) + p(HGNC:TARDBP) increases p(HGNC:TARDBP, loc(GO:"inclusion body")) - pmid:21722302 + pubmed:28669544 - act(p(HGNC:ATF6)) increases p(HGNC:XBP1) + p(HGNC:TARDBP) isA a(MESH:"RNA Splicing Factors") + + - pmid:21722302 + pubmed:28669544 - p(HGNC:ATF6) association path(MESH:"Amyotrophic Lateral Sclerosis") + p(HGNC:TARDBP) decreases path(MESH:Phagocytosis) - pmid:25784053 + pubmed:28669544 - p(HGNC:ATF6) negativeCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") + p(HGNC:TARDBP) decreases path(MESH:Phagocytosis) - pmid:25784053 + pubmed:28669544 - p(HGNC:ATF6) negativeCorrelation path(MESH:"Huntington Disease") + p(HGNC:TARDBP) decreases deg(p(HGNC:APP, loc(GO:lysosome))) + + + pubmed:28669544 + + p(HGNC:TARDBP) decreases deg(p(HGNC:APP)) + + - pmid:21722302 + pubmed:28669544 - complex(p(HGNC:ERN1), p(MESH:"molecular chaperone GRP78")) decreases act(p(HGNC:ERN1)) + p(HGNC:TARDBP) causesNoChange p(HGNC:APP) + + + pubmed:28669544 + + p(HGNC:TARDBP) decreases deg(p(HGNC:APP)) + + - pmid:21722302 + pubmed:30837838 - p(MESH:"molecular chaperone GRP78") negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:TARDBP) regulates p(HGNC:APP) - pmid:21722302 + pubmed:28669544 - p(MESH:"molecular chaperone GRP78") biomarkerFor bp(MESH:"Endoplasmic Reticulum Stress") + p(HGNC:TARDBP) decreases p(HGNC:LAMP1) + + + pubmed:26702100 + + p(HGNC:TARDBP) decreases p(HGNC:LAMP1) + + - pmid:21722302 + pubmed:28669544 - complex(p(MESH:"PERK kinase"), p(MESH:"molecular chaperone GRP78")) decreases act(p(MESH:"PERK kinase")) + p(HGNC:TARDBP) decreases p(HGNC:LAMP2) - + + + pubmed:28669544 + + p(HGNC:TARDBP) decreases bp(GO:"lysosomal lumen acidification") + - pmid:21722302 + pubmed:28669544 - complex(p(HGNC:ATF6), p(MESH:"molecular chaperone GRP78")) decreases act(p(HGNC:ATF6)) + p(HGNC:TARDBP) decreases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) + + + pubmed:30837838 + + p(HGNC:TARDBP) association p(HGNC:TFEB) + + - pmid:25784053 + pubmed:26702100 - p(HGNC:ERN1, pmod(Ph)) increases act(p(HGNC:ERN1), ma(GO:"ribonuclease activity")) + p(HGNC:TARDBP) decreases p(HGNC:TFEB, loc(GO:nucleus)) - + + + pubmed:26702100 + + p(HGNC:TARDBP) increases p(HGNC:TFEB, loc(GO:cytoplasm)) + - pmid:21722302 + pubmed:26702100 - complex(p(HGNC:ERN1), p(HGNC:TRAF2)) increases p(MESH:"ASK1 protein, S cerevisiae") + p(HGNC:TARDBP) decreases p(HGNC:TFEB, loc(GO:nucleus)) - pmid:21722302 + pubmed:26702100 - p(MESH:"ASK1 protein, S cerevisiae") increases bp(GO:"JNK cascade") + p(HGNC:TARDBP) increases p(HGNC:TFEB, loc(GO:cytoplasm)) - pmid:21722302 + pubmed:26702100 - p(MESH:"ASK1 protein, S cerevisiae") increases bp(MESH:Apoptosis) + p(HGNC:TARDBP) decreases p(HGNC:TFEB, loc(GO:lysosome)) - + + + pubmed:28669544 + + p(HGNC:TARDBP) decreases r(HGNC:LAMP1) + - pmid:21722302 + pubmed:26702100 - p(HGNC:BAK1) increases act(p(HGNC:ERN1), ma(kin)) + p(HGNC:TARDBP) decreases r(HGNC:LAMP1) - pmid:21722302 + pubmed:28669544 - p(HGNC:BAK1) increases bp(GO:"mitochondrial outer membrane permeabilization") + p(HGNC:TARDBP) decreases r(HGNC:CTSD) - pmid:21722302 + pubmed:28669544 - p(HGNC:BAK1) increases complex(GO:"mitochondrial permeability transition pore complex") + p(HGNC:TARDBP) decreases r(HGNC:CTSB) - + + + pubmed:28669544 + + p(HGNC:TARDBP) decreases r(HGNC:CLCN7) + + + + pubmed:28669544 + + p(HGNC:TARDBP) decreases r(HGNC:ATP6V1H) + + - pmid:21722302 + pubmed:28669544 - complex(GO:"AIP1-IRE1 complex") increases act(p(HGNC:ERN1)) + p(HGNC:TARDBP) decreases r(HGNC:PSAP) + + + pubmed:28669544 + + p(HGNC:TARDBP) decreases r(HGNC:PSEN2) + + + + + pubmed:28669544 + + p(HGNC:TARDBP) increases a(MESH:Synapses) + + - pmid:21722302 + pubmed:28669544 - composite(p(HGNC:ERN1), p(MESH:"HSP72 Heat-Shock Proteins")) increases p(HGNC:XBP1) + p(HGNC:TARDBP, loc(CONSO:"amyloid-beta oligomers")) increases path(MESH:"Neuronal Plasticity") - pmid:21722302 + pubmed:28669544 - p(HGNC:XBP1) decreases bp(MESH:Apoptosis) + p(HGNC:TARDBP) increases path(MESH:"Neuronal Plasticity") - pmid:21722302 + pubmed:28669544 - p(HGNC:XBP1) increases a(MESH:"Molecular Chaperones") + p(HGNC:TARDBP) regulates act(a(MESH:Microglia)) + + - pmid:21722302 + pubmed:30837838 - p(HGNC:XBP1) decreases bp(GO:autophagy) + p(HGNC:TARDBP) association p(MESH:HIV-1) - pmid:21722302 + pubmed:30837838 - p(HGNC:XBP1) increases p(MESH:"Superoxide Dismutase-1", pmod(MESH:"Mutant Proteins")) + p(HGNC:TARDBP) regulates path(MESH:"Gene Expression Regulation, Viral") - pmid:21722302 + pubmed:30837838 - p(HGNC:XBP1) regulates g(FPLX:"Gamma_secretase") + act(p(HGNC:TARDBP), ma(MESH:"RNA Splicing")) association p(HGNC:CFTR) - pmid:21722302 + pubmed:30837838 - p(HGNC:XBP1) regulates p(HGNC:APP) + p(HGNC:TARDBP) regulates p(HGNC:CFTR) - pmid:21722302 + pubmed:30837838 - p(HGNC:XBP1) association path(MESH:"Alzheimer Disease") + p(HGNC:TARDBP) association path(MESH:"Embryonic Development") - pmid:21722302 + pubmed:30837838 - p(HGNC:XBP1) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:TARDBP) association bp(GO:"neuron development") - pmid:21722302 + pubmed:30837838 - p(HGNC:XBP1) association a(CHEBI:"amyloid-beta") + p(HGNC:TARDBP) association path(MESH:"Muscular Atrophy, Spinal") + + - pmid:21722302 + pubmed:30837838 - p(HGNC:XBP1) association p(HGNC:VAPB) + p(HGNC:TARDBP, loc(MESH:Cytoplasm)) increases a(MESH:"Inclusion Bodies") + + + + + + + + + + + + + + + + - pmid:25784053 + pubmed:30837838 - act(p(HGNC:XBP1), ma(tscript)) increases bp(GO:"response to misfolded protein") + p(HGNC:TARDBP) association path(MESH:"RNA Stability") - pmid:21722302 + pubmed:30837838 - p(HGNC:EIF2A, pmod(Ph, Ser, 51)) decreases bp(GO:translation) + p(HGNC:TARDBP) association path(MESH:"Transcription, Genetic") - pmid:21722302 + pubmed:30837838 - p(HGNC:EIF2A, pmod(Ph, Ser, 51)) increases bp(GO:"cap-independent translational initiation") + p(HGNC:TARDBP) association path(MESH:"Protein Biosynthesis") - pmid:21722302 + pubmed:30837838 - p(HGNC:EIF2A, pmod(Ph, Ser, 51)) increases p(HGNC:ATF4) + p(HGNC:TARDBP) decreases path(MESH:"Protein Biosynthesis") + + + pubmed:30837838 + + p(HGNC:TARDBP) association bp(GO:"primary miRNA processing") + + - pmid:21722302 + pubmed:30837838 - p(HGNC:EIF2A) increases p(HGNC:NUPR1) + p(HGNC:TARDBP) association p(MESH:"RNA, Long Noncoding") - pmid:21722302 + pubmed:30837838 - p(HGNC:EIF2A) increases p(HGNC:ATF4) + p(HGNC:TARDBP) association path(MESH:"RNA Transport") - pmid:21722302 + pubmed:30837838 - p(HGNC:EIF2A) increases complex(GO:"CHOP-C/EBP complex") + p(HGNC:TARDBP) association path(MESH:"Active Transport, Cell Nucleus") + + + pubmed:30837838 + + p(HGNC:TARDBP) regulates p(HGNC:FUS) + + - pmid:24563850 + pubmed:30837838 - p(HGNC:EIF2A) association p(HGNC:HSPB8) + p(HGNC:TARDBP) regulates p(HGNC:SNCA) - pmid:21722302 + pubmed:30837838 - bp(GO:"cap-independent translational initiation") increases p(HGNC:ATF4) + p(HGNC:TARDBP) regulates p(HGNC:HTT) - pmid:21722302 + pubmed:30837838 - p(HGNC:ATF4) increases a(MESH:"Molecular Chaperones") + p(HGNC:TARDBP) regulates path(MESH:"RNA Splicing") - pmid:21722302 + pubmed:30837838 - p(HGNC:ATF4) increases p(HGNC:MAP1LC3B) + p(HGNC:TARDBP) negativeCorrelation p(MESH:Neurons) - - - pmid:21722302 - - p(HGNC:ATF4) increases p(HGNC:ATG5) - + + + + + - pmid:21722302 + pubmed:30837838 - p(HGNC:ATF4) increases bp(GO:autophagy) + p(HGNC:TARDBP) regulates p(NCBIGENE:5740544) + + - pmid:21722302 + pubmed:30837838 - p(HGNC:ATF4) increases p(MESH:"parkin protein") + p(HGNC:TARDBP) regulates p(HGNC:G3BP1) - pmid:25784053 + pubmed:30837838 - p(HGNC:ATF4) increases p(HGNC:DDIT3) + p(HGNC:TARDBP) regulates p(HGNC:TIA1) @@ -103422,873 +104496,983 @@

Statements

- pmid:24563850 + pubmed:30837838 - act(p(HGNC:KEAP1)) increases deg(p(HGNC:NFE2L2)) + p(HGNC:TARDBP) increases p(MESH:MicroRNAs) + + + + - pmid:29121589 + pubmed:30837838 - p(HGNC:KEAP1) increases complex(p(HGNC:CUL3), p(HGNC:KEAP1), p(HGNC:NFE2L2)) + p(HGNC:TARDBP) increases r(HGNC:NEAT1) - pmid:29121589 + pubmed:30837838 - p(HGNC:KEAP1) isA p(ECCODE:"2.3.2.27") + p(HGNC:TARDBP) increases r(HGNC:MALAT1) + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - pmid:21722302 + pubmed:30837838 - p(MESH:"Nrf2a protein, zebrafish") increases a(MESH:"Molecular Chaperones") + p(HGNC:TARDBP, loc(GO:cytoplasm)) increases a(MESH:"Toxic Actions") + + - pmid:21722302 + pubmed:30837838 - p(MESH:"Nrf2a protein, zebrafish", pmod(Ph)) increases p(HGNCGENEFAMILY:"Soluble glutathione S-transferases") + p(HGNC:TARDBP) regulates path(MESH:"Chromatin Assembly and Disassembly") + + + + + + + + + + + + + + + + + + + + + + - pmid:21722302 + pubmed:30837838 - p(MESH:"Nrf2a protein, zebrafish", pmod(Ph)) increases p(HGNCGENEFAMILY:"NADH:ubiquinone oxidoreductase core subunits") + act(p(HGNC:TARDBP), ma(GO:"regulation of RNA binding")) negativeCorrelation p(HGNC:TARDBP, pmod(go:0006473 ! "protein acetylation")) + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + - pmid:21722302 + pubmed:30837838 - p(MESH:"Nrf2a protein, zebrafish", pmod(Ph)) increases p(MESH:"Heme Oxygenase-1") + deg(p(HGNC:TARDBP)) association bp(GO:"vacuole fusion") - pmid:27491084 + pubmed:30837838 - a(MESH:"Molecular Chaperones") decreases path(HBP:proteotoxicity) + deg(p(HGNC:TARDBP)) association path(MESH:"Endoplasmic Reticulum-Associated Degradation") - pmid:23746257 + pubmed:30837838 - a(MESH:"Molecular Chaperones") decreases a(MESH:"Protein Aggregates") + deg(p(HGNC:TARDBP)) association path(MESH:Autophagy) - pmid:25784053 + pubmed:30837838 - a(MESH:"Molecular Chaperones") decreases path(MESH:"Protein Aggregation, Pathological") + p(HGNC:TARDBP) increases a(MESH:Endosomes) - pmid:21882945 + pubmed:30837838 - a(MESH:"Molecular Chaperones") association bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") + p(HGNC:TARDBP) increases path(MESH:Growth) - pmid:29311797 + pubmed:30837838 - a(MESH:"Molecular Chaperones") association bp(GO:"protein folding") + p(HGNC:TARDBP) increases path(MESH:Survival) - pmid:29311797 + pubmed:30837838 - a(MESH:"Molecular Chaperones") association bp(MESH:Proteolysis) + p(HGNC:TARDBP) decreases path(MESH:"Mitochondrial Size") - pmid:29311797 + pubmed:30837838 - a(MESH:"Molecular Chaperones") association deg(p(MESH:Proteins, pmod(HBP:misfolded))) + p(HGNC:TARDBP) decreases path(MESH:Movement) - pmid:27181519 + pubmed:30837838 - a(MESH:"Molecular Chaperones") regulates bp(GO:"stress granule disassembly") + p(HGNC:TARDBP) increases bp(GO:"mitochondrial fission") - pmid:21722302 + pubmed:30837838 - bp(GO:"ERAD pathway") increases deg(p(MESH:Proteins, pmod(HBP:misfolded))) + p(HGNC:TARDBP) increases bp(GO:"mitochondrial fragmentation involved in apoptotic process") - pmid:21722302 + pubmed:30837838 - bp(GO:"ERAD pathway") increases deg(p(MESH:Proteins, pmod(HBP:misfolded))) + p(HGNC:TARDBP) decreases path(MESH:"Mitochondrial Dynamics") - pmid:21722302 + pubmed:30837838 - bp(GO:"ERAD pathway") association path(MESH:"Amyotrophic Lateral Sclerosis") + p(HGNC:TARDBP) increases path(MESH:"Protein Carbonylation") - pmid:21722302 + pubmed:30837838 - bp(GO:"ERAD pathway") decreases bp(MESH:"Endoplasmic Reticulum Stress") + p(HGNC:TARDBP) increases p(NCBIGENE:41503) + + - pmid:21722302 + pubmed:30837838 - bp(GO:"ERAD pathway") decreases p(MESH:"derlin-1 protein, mouse") + p(HGNC:TARDBP, loc(GO:cytoplasm)) negativeCorrelation p(HGNC:SOD1, pmod(MESH:"Protein Aggregates"), var("?")) - pmid:14556719 + pubmed:30837838 - bp(GO:"ERAD pathway") regulates deg(p(HGNC:CFTR)) + p(HGNC:TARDBP) increases p(HGNC:DNM1L) - pmid:14556719 + pubmed:30837838 - bp(GO:"ERAD pathway") increases deg(p(HGNC:PRNP, pmod(HBP:misfolding))) + p(HGNC:TARDBP) increases p(HGNC:FIS1) - pmid:24457024 + pubmed:30837838 - bp(GO:"ERAD pathway") association complex(p(HGNC:BAG6), p(MESH:Proteins, pmod(HBP:misfolding))) + p(HGNC:TARDBP) increases tloc(p(HGNC:CHCHD10), fromLoc(GO:mitochondrion), toLoc(GO:nucleus)) - pmid:21722302 + pubmed:30837838 - p(MESH:"OASIS protein, rat") increases bp(MESH:"Bone Development") + p(HGNC:TARDBP) decreases p(MESH:"Heat-Shock Proteins") - pmid:21722302 + pubmed:30837838 - p(HGNC:CREB3L2) regulates p(HGNC:SEC23A) + p(HGNC:TARDBP) decreases p(MESH:Histones) - pmid:21722302 + pubmed:30837838 - p(HGNC:SEC23A) increases tloc(a(MESH:Proteins), fromLoc(GO:"endoplasmic reticulum"), toLoc(GO:"Golgi apparatus")) + p(HGNC:TARDBP, loc(GO:nucleus)) regulates r(HGNC:SS18) + + - pmid:22908190 + pubmed:30837838 - a(MESH:Proteins) positiveCorrelation act(p(HGNC:RAB5A)) + p(HGNC:TARDBP) increases p(CONSO:"Histone H3", pmod(mod:00430 ! "trimethylated residue", Lys, 9)) - pmid:22908190 + pubmed:30837838 - a(MESH:Proteins) positiveCorrelation bp(GO:endocytosis) + act(p(HGNC:TARDBP), ma(GO:"nucleic acid binding")) negativeCorrelation a(PUBCHEM:68476) + + + + - pmid:24457024 + pubmed:26091809 - tloc(a(MESH:Proteins), fromLoc(GO:cytosol), toLoc(HBP:"20 S Proteasome")) increases act(p(HGNC:PSMD14)) + p(HGNC:TARDBP) positiveCorrelation path(MESH:Aging) - pmid:18930136 + pubmed:26091809 - tloc(a(MESH:Proteins), fromLoc(GO:intracellular), toLoc(GO:lysosome)) increases deg(a(MESH:Proteins)) + p(HGNC:TARDBP) increases path(MESH:"Intranuclear Inclusion Bodies") - pmid:27181519 + pubmed:26091809 - a(MESH:Proteins, loc(GO:phagophore)) increases a(GO:autophagosome) + p(HGNC:TARDBP) increases path(MESH:Mortality) - pmid:21722302 + pubmed:26702100 - p(HGNC:ATF3) increases a(MESH:"Molecular Chaperones") + p(HGNC:TARDBP) increases p(HGNC:MTOR) - pmid:21722302 + pubmed:26702100 - bp(GO:"apoptotic signaling pathway") decreases complex(GO:"mitochondrial permeability transition pore complex") + p(HGNC:TARDBP) increases p(HGNC:MTOR) - pmid:21722302 + pubmed:26702100 - complex(GO:"mitochondrial permeability transition pore complex") directlyIncreases bp(GO:"regulation of mitochondrial membrane potential") + p(HGNC:TARDBP) regulates p(HGNC:MTOR) - pmid:21722302 + pubmed:26702100 - complex(GO:"mitochondrial permeability transition pore complex") increases bp(GO:"release of cytochrome c from mitochondria") + p(HGNC:TARDBP) increases act(p(HGNCGENEFAMILY:"MTOR complex 1")) - pmid:21722302 + pubmed:26702100 - bp(GO:"negative regulation of mitochondrial membrane potential") increases bp(GO:"release of cytochrome c from mitochondria") + act(p(HGNC:TARDBP)) association p(HGNCGENEFAMILY:"MTOR complex 1") - - - - - - - pmid:21722302 + pubmed:26702100 - composite(p(HGNC:APAF1), p(HGNC:CASP9), p(HGNC:CYC1)) increases a(MESH:Apoptosomes) + p(HGNC:TARDBP) increases p(HGNC:RPTOR) - pmid:21722302 + pubmed:26702100 - p(HGNC:CASP9) increases p(HGNC:CASP3) + p(HGNC:TARDBP) causesNoChange p(HGNC:RPTOR) - pmid:21722302 + pubmed:26702100 - p(HGNC:CASP9) increases p(HGNC:CASP7) + p(HGNC:TARDBP) association p(HGNC:RPTOR) - pmid:21722302 + pubmed:26702100 - p(HGNC:CASP9) increases p(HGNC:CASP6) + p(HGNC:TARDBP) increases p(HGNC:RPTOR) - - - pmid:24027553 + pubmed:26702100 - act(p(HGNC:CASP6)) increases p(HGNC:MAPT, frag("?_*")) + p(HGNC:TARDBP) regulates p(HGNC:RPTOR) - pmid:24027553 + pubmed:26702100 - act(p(HGNC:CASP6)) increases p(HGNC:MAPT, frag("?_*")) + p(HGNC:TARDBP) causesNoChange p(HGNC:LAMTOR1) - pmid:24027553 + pubmed:26702100 - act(p(HGNC:CASP6)) increases p(HGNC:MAPT, frag("1_?")) + p(HGNC:TARDBP) causesNoChange p(HGNC:RRAGB) - pmid:24027553 + pubmed:26702100 - act(p(HGNC:CASP6)) increases p(HGNC:MAPT, frag("1_?")) + p(HGNC:TARDBP) increases r(HGNC:RPTOR) - pmid:24027553 + pubmed:26702100 - act(p(HGNC:CASP6)) increases bp(GO:"apoptotic process") + p(HGNC:TARDBP) increases r(HGNC:RPTOR) - pmid:24027553 + pubmed:26702100 - act(p(HGNC:CASP6)) increases p(HGNC:MAPT, var("p.D421*")) + p(HGNC:TARDBP) increases act(r(HGNC:RPTOR)) - pmid:24027553 + pubmed:26702100 - act(p(HGNC:CASP6)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:TARDBP) causesNoChange r(HGNC:MTOR) - - - - - - - pmid:21722302 + pubmed:26702100 - composite(p(HGNC:CASP3), p(HGNC:CASP6), p(HGNC:CASP7)) increases bp(MESH:Apoptosis) + p(HGNC:TARDBP) causesNoChange r(HGNC:RRAGB) - pmid:21722302 + pubmed:26702100 - p(HGNC:CASP2) increases bp(MESH:Apoptosis) + p(HGNC:TARDBP) causesNoChange r(HGNC:LAMTOR1) - pmid:21722302 + pubmed:26702100 - complex(GO:"PUMA-BCL-2 complex") increases bp(MESH:Apoptosis) + p(HGNC:TARDBP) causesNoChange r(HGNC:LAMTOR3) - pmid:21722302 + pubmed:26702100 - complex(GO:"CHOP-C/EBP complex") increases bp(MESH:"DNA Damage") + p(HGNC:TARDBP) causesNoChange r(HGNC:LAMTOR2) - pmid:21722302 + pubmed:26702100 - complex(GO:"CHOP-C/EBP complex") increases bp(MESH:"Cell Death") + p(HGNC:TARDBP) causesNoChange r(HGNC:LAMTOR5) - pmid:21722302 + pubmed:26702100 - complex(GO:"CHOP-C/EBP complex") increases bp(MESH:"Cell Death") + p(HGNC:TARDBP) causesNoChange r(HGNC:LAMTOR4) - pmid:21722302 + pubmed:26702100 - complex(GO:"CHOP-C/EBP complex") decreases p(HGNC:BCL2) + p(HGNC:TARDBP) causesNoChange r(HGNC:RRAGA) - pmid:21722302 + pubmed:26702100 - complex(GO:"CHOP-C/EBP complex") increases a(MESH:"Reactive Oxygen Species") + p(HGNC:TARDBP) causesNoChange r(HGNC:RRAGC) - pmid:21722302 + pubmed:26702100 - complex(GO:"CHOP-C/EBP complex") increases p(MESH:"Casp11 protein, mouse") + p(HGNC:TARDBP) causesNoChange r(HGNC:RRAGD) - pmid:21722302 + pubmed:26702100 - complex(GO:"CHOP-C/EBP complex") increases complex(GO:"BIM-BCL-2 complex") + p(HGNC:TARDBP) causesNoChange r(HGNC:FLCN) - pmid:21722302 + pubmed:26702100 - complex(GO:"CHOP-C/EBP complex") decreases r(HGNC:BCL2) + p(HGNC:TARDBP) causesNoChange p(HGNC:RRAGA, loc(GO:lysosome)) - pmid:21722302 + pubmed:26702100 - complex(GO:"CHOP-C/EBP complex") increases p(HGNC:MAP1LC3B) + p(HGNC:TARDBP) causesNoChange p(HGNC:RRAGC, loc(GO:lysosome)) - pmid:21722302 + pubmed:26702100 - complex(GO:"CHOP-C/EBP complex") increases p(HGNC:ATG5) + p(HGNC:TARDBP) causesNoChange p(HGNC:TFEB, var("p.Met1_Val30del"), loc(GO:lysosome)) - pmid:21722302 + pubmed:26702100 - complex(GO:"CHOP-C/EBP complex") increases bp(GO:autophagy) + p(HGNC:TARDBP) causesNoChange p(HGNC:TFEB, var("p.Gln10Ala"), var("p.Lys11Ala"), loc(GO:lysosome)) + + - pmid:21722302 + pubmed:26702100 - complex(GO:"CHOP-C/EBP complex") decreases p(MESH:"parkin protein") + p(HGNC:TARDBP) decreases a(GO:lysosome) - pmid:21722302 + pubmed:26702100 - complex(GO:"CHOP-C/EBP complex") biomarkerFor bp(MESH:"Endoplasmic Reticulum Stress") + p(HGNC:TARDBP) decreases p(HGNCGENEFAMILY:Cathepsins) - pmid:30126037 + pubmed:26702100 - bp(MESH:"DNA Damage") association bp(GO:"cellular senescence") + p(HGNC:TARDBP) decreases r(HGNCGENEFAMILY:Cathepsins) - pmid:21722302 + pubmed:26702100 - bp(MESH:"Cell Death") increases tloc(p(MESH:"alpha-Synuclein"), fromLoc(GO:intracellular), toLoc(GO:"extracellular space")) + p(HGNC:TARDBP) decreases a(MESH:"Vacuolar Proton-Translocating ATPases") - pmid:21722302 + pubmed:26702100 - p(MESH:"Casp11 protein, mouse") increases p(HGNC:CASP1) + p(HGNC:TARDBP) decreases p(HGNC:ATG5) - pmid:21722302 + pubmed:26702100 - p(MESH:"Casp11 protein, mouse") increases p(HGNC:CASP3) + p(HGNC:TARDBP) decreases r(HGNC:ATG5) - pmid:21722302 + pubmed:26702100 - p(HGNC:CASP1) increases bp(MESH:"Cell Death") + p(HGNC:TARDBP) decreases p(HGNC:BECN1) - pmid:28019679 + pubmed:26702100 - p(HGNC:CASP1) increases act(p(HGNC:IL18)) + p(HGNC:TARDBP) decreases r(HGNC:BECN1) - pmid:23702978 + pubmed:26702100 - act(p(HGNC:CASP1)) increases act(p(HGNC:IL18)) + p(HGNC:TARDBP) decreases p(HGNC:ATG9B) - pmid:23702978 + pubmed:26702100 - act(p(HGNC:CASP1)) increases act(p(HGNC:IL18)) + p(HGNC:TARDBP) decreases r(HGNC:ATG9B) - pmid:23702978 + pubmed:26702100 - act(p(HGNC:CASP1)) increases sec(p(HGNC:IL18)) + p(HGNC:TARDBP) decreases a(GO:autophagosome) - pmid:24561250 + pubmed:26702100 - p(HGNC:CASP1) increases p(HGNC:IL18) + p(HGNC:TARDBP) decreases a(GO:autophagosome) - pmid:24561250 + pubmed:26702100 - p(HGNC:CASP1) increases p(HGNC:IL18) + p(HGNC:TARDBP) decreases p(HGNC:SQSTM1) - pmid:27314526 + pubmed:26702100 - act(p(HGNC:CASP1)) increases act(p(HGNC:IL18)) + p(HGNC:TARDBP) decreases p(HGNC:SQSTM1) - pmid:27314526 + pubmed:26702100 - sec(p(HGNC:CASP1)) increases act(p(HGNC:IL18)) + p(HGNC:TARDBP) decreases p(HGNC:MAP1LC3A) - pmid:27314526 + pubmed:26702100 - act(p(HGNC:CASP1)) increases act(p(HGNC:IL18)) + p(HGNC:TARDBP) decreases p(HGNC:MAP1LC3B) - pmid:27314526 + pubmed:26702100 - act(p(HGNC:CASP1)) increases act(p(HGNC:IL18)) + p(HGNC:TARDBP) regulates a(GO:autolysosome) - pmid:28019679 + pubmed:26702100 - p(HGNC:CASP1) increases act(p(HGNC:IL1B)) + p(HGNC:TARDBP) increases bp(GO:"autophagosome-lysosome fusion") - pmid:23702978 + pubmed:26702100 - act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) + p(HGNC:TARDBP) increases bp(GO:"autophagosome-lysosome fusion") - pmid:23702978 + pubmed:26702100 - act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) + p(HGNC:TARDBP) decreases r(HGNC:SQSTM1) - pmid:23702978 + pubmed:26702100 - act(p(HGNC:CASP1)) increases sec(p(HGNC:IL1B)) + p(HGNC:TARDBP) increases g(HGNC:DCTN1) - pmid:23702978 + pubmed:26702100 - act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) + p(HGNC:TARDBP) increases p(HGNC:DCTN1) - pmid:24561250 + pubmed:26702100 - p(HGNC:CASP1) increases p(HGNC:IL1B) + p(HGNC:TARDBP) causesNoChange a(MESH:Dyneins) - pmid:27314526 + pubmed:26702100 - act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) + p(HGNC:TARDBP) increases p(HGNC:EIF4EBP1, pmod(go:0006468 ! "protein phosphorylation")) - pmid:27314526 + pubmed:26702100 - sec(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) + p(HGNC:TARDBP) increases p(HGNC:RPS6KB1, pmod(go:0006468 ! "protein phosphorylation")) - pmid:27314526 + pubmed:26702100 - act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) + p(HGNC:TARDBP) causesNoChange r(HGNC:RPS6KB1) - pmid:27314526 + pubmed:26702100 - act(p(HGNC:CASP1)) increases act(p(HGNC:IL1B)) + p(HGNC:TARDBP) increases g(HGNC:RPTOR) - pmid:28019679 + pubmed:26702100 - act(p(HGNC:CASP1)) increases a(CHEBI:"nitric oxide") + p(HGNC:TARDBP) decreases g(HGNC:ATP6V1H) - pmid:28019679 + pubmed:26702100 - act(p(HGNC:CASP1)) increases sec(p(HGNC:TNF)) + p(HGNC:TARDBP) decreases g(HGNC:CTSB) - pmid:28019679 + pubmed:26702100 - act(p(HGNC:CASP1)) increases bp(GO:pyroptosis) + p(HGNC:TARDBP) decreases g(HGNC:CTSD) - pmid:23702978 + pubmed:26702100 - act(p(HGNC:CASP1)) increases bp(GO:pyroptosis) + p(HGNC:TARDBP) decreases g(HGNC:LAMP1) - - - pmid:24561250 + pubmed:26702100 - p(HGNC:CASP1) association composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) + p(HGNC:TARDBP) decreases g(HGNC:PSAP) - pmid:27314526 + pubmed:26702100 - act(p(HGNC:CASP1)) increases act(p(HGNC:IL33)) + p(HGNC:TARDBP) decreases g(HGNC:SGSH) - pmid:27314526 + pubmed:26702100 - act(p(HGNC:CASP1)) increases act(p(HGNC:IL33)) + p(HGNC:TARDBP) decreases g(HGNC:BECN1) @@ -104299,144 +105483,125 @@

Statements

- pmid:21722302 + pubmed:22372633 - p(MESH:Oxidoreductases) increases tloc(p(MESH:Proteins, pmod(HBP:misfolded)), fromLoc(GO:"endoplasmic reticulum"), toLoc(GO:cytoplasm)) + p(HGNC:FUS) increases r(HGNC:HDAC6) - - - pmid:21722302 - - p(HGNCGENEFAMILY:Proteasome) decreases deg(p(MESH:Proteins, pmod(HBP:misfolded))) - - - - - pmid:21722302 - - p(HGNCGENEFAMILY:Proteasome) increases deg(p(MESH:Proteins, pmod(HBP:misfolded))) - - - pmid:24027553 + pubmed:30935091 - act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(HGNC:MAPT, pmod(Ub))) + p(HGNC:FUS) association path(DOID:"amyotrophic lateral sclerosis") - pmid:24027553 + pubmed:30935091 - p(HGNCGENEFAMILY:Proteasome) increases deg(p(HGNC:MAPT, pmod(Ub))) + p(HGNC:FUS) regulates act(p(HGNC:HDAC6)) - pmid:24027553 + pubmed:26631930 - act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(HGNC:MAPT)) + p(HGNC:FUS) decreases p(CONSO:"4R tau") - pmid:24027553 + pubmed:26631930 - p(HGNCGENEFAMILY:Proteasome) increases deg(p(HGNC:MAPT)) + p(HGNC:FUS) decreases p(CONSO:"Tau isoform F (441 aa)") - pmid:24027553 + pubmed:26631930 - act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(HGNC:MAPT)) + p(HGNC:FUS) decreases p(CONSO:"Tau isoform C (410 aa)") - pmid:24027553 + pubmed:26631930 - act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(RGD:Mapt)) + p(HGNC:FUS) association path(MESH:"Frontotemporal Lobar Degeneration") - pmid:24027553 + pubmed:27181519 - act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(RGD:Mapt, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404))) + p(HGNC:FUS) regulates bp(MESH:"Transcription, Genetic") - pmid:24027553 + pubmed:27181519 - act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(HGNC:MAPT, pmod(Ph))) + p(HGNC:FUS) association bp(GO:"RNA splicing") - pmid:24027553 + pubmed:27181519 - act(p(HGNCGENEFAMILY:Proteasome)) causesNoChange deg(a(HBP:"Tau aggregates")) + p(HGNC:FUS) association bp(GO:"DNA repair") - - - pmid:24027553 - - act(p(HGNCGENEFAMILY:Proteasome)) causesNoChange deg(a(HBP:"Tau oligomers")) - + - pmid:21722302 + pubmed:27181519 - a(MESH:Autophagosomes) increases p(MESH:Proteins, pmod(HBP:misfolded)) + p(HGNC:FUS, loc(GO:cytosol)) association complex(GO:"cytoplasmic stress granule") - pmid:24027553 + pubmed:27181519 - a(MESH:Autophagosomes) positiveCorrelation a(HBP:"Tau aggregates") + p(HGNC:FUS) association path(DOID:"motor neuron disease") - pmid:24027553 + pubmed:27181519 - a(MESH:Autophagosomes) positiveCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNC:FUS)) regulates a(CHEBI:"nucleic acid") @@ -104445,474 +105610,471 @@

Statements

- pmid:21722302 + pubmed:30837838 - composite(a(MESH:Autophagosomes), a(MESH:Lysosomes)) increases deg(a(MESH:Autophagosomes)) + p(HGNC:FUS) association path(MESH:"Amyotrophic Lateral Sclerosis") - - - pmid:25784053 + pubmed:29758300 - a(MESH:Lysosomes) increases bp(MESH:Proteolysis) + path(MESH:"Bulbo-Spinal Atrophy, X-Linked") negativeCorrelation bp(GO:macroautophagy) - pmid:25784053 + pubmed:14556719 - a(MESH:Lysosomes) decreases path(MESH:"Protein Aggregation, Pathological") + path(MESH:"Bulbo-Spinal Atrophy, X-Linked") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) - pmid:24027553 + pubmed:14556719 - a(MESH:Lysosomes) positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:"Bulbo-Spinal Atrophy, X-Linked") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) - pmid:29238289 + pubmed:18930136 - act(a(MESH:Lysosomes)) decreases sec(p(HGNC:MAPT)) + path(MESH:"Bulbo-Spinal Atrophy, X-Linked") negativeCorrelation bp(GO:autophagy) - pmid:21722302 + pubmed:22372633 - complex(GO:"Atg1/ULK1 kinase complex") increases bp(GO:autophagy) + complex(GO:"proteasome complex") decreases composite(p(HGNC:HDAC6), p(HGNC:MAPT)) - pmid:21722302 + pubmed:30935091 - complex(GO:"Atg1/ULK1 kinase complex") increases a(GO:phagophore) + complex(GO:"proteasome complex") decreases p(HGNC:MAPT, pmod(CONSO:"protein aggregates"), pmod(go:0006473 ! "protein acetylation")) - pmid:21722302 + pubmed:30935091 - a(GO:phagophore) increases a(MESH:Autophagosomes) + complex(GO:"proteasome complex") decreases p(HGNC:HDAC6, pmod(CONSO:"protein aggregates")) + + - pmid:18930136 + pubmed:22040696 - a(GO:phagophore) increases a(GO:autophagosome) + complex(GO:"proteasome complex") regulates p(FPLX:CHRN) - pmid:26702100 + pubmed:22040696 - p(HGNCGENEFAMILY:"MTOR complex 1") regulates p(HGNC:TFEB) + complex(GO:"proteasome complex") increases bp(GO:"modulation of chemical synaptic transmission") - pmid:26702100 + pubmed:22040696 - act(p(HGNCGENEFAMILY:"MTOR complex 1")) negativeCorrelation p(HGNC:RPS6KB1, pmod(Ph, Thr, 389)) + complex(GO:"proteasome complex") regulates p(HGNC:RIC3) - pmid:26702100 + pubmed:29758300 - act(p(HGNCGENEFAMILY:"MTOR complex 1")) association p(HGNC:RPS6KB1) + complex(GO:"proteasome complex") association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:26702100 + pubmed:29758300 - p(HGNCGENEFAMILY:"MTOR complex 1") association act(p(HGNC:TARDBP)) + complex(GO:"proteasome complex") association p(HGNC:MAPT, frag("?")) - pmid:26702100 + pubmed:29758300 - p(HGNCGENEFAMILY:"MTOR complex 1") increases p(HGNC:TFEB, pmod(Ph)) + complex(GO:"proteasome complex") increases deg(p(HGNC:SNCA)) - pmid:26702100 + pubmed:14556719 - p(HGNCGENEFAMILY:"MTOR complex 1") increases p(HGNC:TFEB, pmod(Ph, Ser, 211)) + complex(GO:"proteasome complex") increases deg(p(MESH:Proteins, pmod(GO:"protein K48-linked ubiquitination"))) - pmid:21722302 + pubmed:14556719 - p(HGNCGENEFAMILY:"TSC complex") regulates p(HGNC:MTOR) + complex(GO:"proteasome complex") increases deg(p(MESH:Proteins, pmod(GO:"protein K63-linked ubiquitination"))) - pmid:21722302 + pubmed:14556719 - path(MESH:Starvation) increases act(p(HGNC:PRKAA1)) + complex(GO:"proteasome complex") increases deg(complex(p(HGNC:OAZ1), p(HGNC:ODC1))) - pmid:29758300 + pubmed:14556719 - path(MESH:Starvation) increases rxn(reactants(a(CHEBI:lipid)), products(a(CHEBI:"fatty acid"))) + complex(GO:"proteasome complex") increases a(CHEBI:peptide) - pmid:29758300 + pubmed:14556719 - path(MESH:Starvation) increases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) + complex(GO:"proteasome complex") regulates bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:29758300 + pubmed:14556719 - path(MESH:Starvation) increases complex(p(HGNC:TFEB), p(INTERPRO:"cAMP response element binding (CREB) protein")) + complex(GO:"proteasome complex") increases deg(a(CHEBI:amyloid-beta)) - pmid:18930136 + pubmed:22908190 - path(MESH:Starvation) increases tloc(p(HGNC:WDFY3), fromLoc(GO:nucleus), toLoc(GO:cytoplasm)) + act(complex(GO:"proteasome complex")) negativeCorrelation a(CHEBI:amyloid-beta) - pmid:29238289 + pubmed:14556719 - path(MESH:Starvation) increases sec(p(HGNC:MAPT)) + act(complex(GO:"proteasome complex")) negativeCorrelation bp(GO:aging) - pmid:26702100 + pubmed:22908190 - path(MESH:Starvation) decreases p(HGNC:MTOR) + act(complex(GO:"proteasome complex")) negativeCorrelation bp(GO:aging) - pmid:26702100 + pubmed:22908190 - path(MESH:Starvation) decreases p(HGNC:RPS6KB1, pmod(Ph, Thr, 389)) + act(complex(GO:"proteasome complex")) negativeCorrelation bp(GO:aging) - pmid:26702100 + pubmed:14556719 - path(MESH:Starvation) increases a(GO:autophagosome) + act(complex(GO:"proteasome complex")) negativeCorrelation p(HGNC:SOD1, var("?")) - pmid:26702100 + pubmed:14556719 - path(MESH:Starvation) decreases a(GO:autolysosome) + act(complex(GO:"proteasome complex")) decreases bp(GO:autophagy) - pmid:21722302 + pubmed:18930136 - bp(MESH:"Heat-Shock Response") increases act(p(HGNC:PRKAA1)) + act(complex(GO:"proteasome complex")) negativeCorrelation bp(GO:autophagy) - pmid:14556719 + pubmed:14556719 - bp(MESH:"Heat-Shock Response") increases bp(GO:"response to unfolded protein") + act(complex(GO:"proteasome complex")) decreases p(HGNC:HTT, frag("?")) - pmid:23746257 + pubmed:22908190 - bp(MESH:"Heat-Shock Response") increases a(MESH:"Heat-Shock Proteins") + complex(GO:"proteasome complex") increases deg(p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination"))) - pmid:23746257 + pubmed:22908190 - bp(MESH:"Heat-Shock Response") association p(FPLX:HSP90) + complex(GO:"proteasome complex") increases deg(p(MESH:Proteins, pmod(go:0070936 ! "protein K48-linked ubiquitination"))) - pmid:23746257 + pubmed:22908190 - bp(MESH:"Heat-Shock Response") regulates bp(HBP:Proteostasis) + act(complex(GO:"proteasome complex")) negativeCorrelation a(CONSO:"paired helical filaments") - pmid:29807032 + pubmed:22908190 - bp(MESH:"Heat-Shock Response") association act(p(NCBIGENE:140621)) + act(complex(GO:"proteasome complex")) negativeCorrelation a(GO:"neurofibrillary tangle") - pmid:29807032 + pubmed:22908190 - bp(MESH:"Heat-Shock Response") increases act(p(NCBIGENE:140621)) + act(complex(GO:"proteasome complex")) negativeCorrelation complex(a(GO:"proteasome regulatory particle"), p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) - pmid:29807032 + pubmed:22908190 - bp(MESH:"Heat-Shock Response") increases p(NCBIGENE:492507) + complex(GO:"proteasome complex") increases deg(p(FPLX:PKA, pmod(go:0016567 ! "protein ubiquitination"))) - pmid:29807032 + pubmed:22908190 - bp(MESH:"Heat-Shock Response") increases r(MESH:"corticotropin releasing factor-binding protein") + complex(GO:"proteasome complex") increases deg(p(HGNC:MAPT)) - pmid:29807032 + pubmed:22908190 - bp(MESH:"Heat-Shock Response") decreases a(MESH:"Embryonic Structures") + complex(GO:"proteasome complex") increases deg(p(HGNC:MAPT)) - pmid:29807032 + pubmed:22908190 - bp(MESH:"Heat-Shock Response") decreases a(MESH:"Embryonic Structures") + act(complex(GO:"proteasome complex")) negativeCorrelation p(HGNC:MAPT) - pmid:29807032 + pubmed:26751493 - bp(MESH:"Heat-Shock Response") decreases a(MESH:"Embryonic Structures") + act(complex(GO:"proteasome complex")) negativeCorrelation p(HGNC:MAPT) - pmid:21722302 + pubmed:17954934 - a(CHEBI:tunicamycin) increases bp(GO:autophagy) + act(complex(GO:"proteasome complex")) increases deg(p(HGNC:MAPT)) - pmid:21722302 + pubmed:24457024 - a(MESH:"Proteasome Inhibitors") increases bp(GO:autophagy) + complex(GO:"proteasome complex") regulates complex(a(MESH:Proteins), a(MESH:Ubiquitin)) - - - - - pmid:21722302 + pubmed:18930136 - p(MESH:"Superoxide Dismutase-1", pmod(MESH:"Mutant Proteins")) increases bp(HBP:"protein aggregation") + act(complex(GO:"proteasome complex")) decreases path(CONSO:Neurodegeneration) - - - - - pmid:21722302 + pubmed:18930136 - bp(HBP:"protein aggregation") increases bp(MESH:"Cell Death") + act(complex(GO:"proteasome complex")) decreases p(HGNC:SQSTM1) - pmid:21722302 + pubmed:18930136 - bp(HBP:"protein aggregation") association path(MESH:"Neurodegenerative Diseases") + act(complex(GO:"proteasome complex")) decreases r(HGNC:SQSTM1) - pmid:21722302 + pubmed:30116051 - bp(HBP:"protein aggregation") association path(MESH:"Neurodegenerative Diseases") + complex(GO:"proteasome complex") increases deg(p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) - pmid:21722302 + pubmed:30116051 - bp(HBP:"protein aggregation") association path(MESH:"Alzheimer Disease") + complex(GO:"proteasome complex") increases deg(a(CONSO:"Tau oligomers")) - pmid:21722302 + pubmed:17954934 - bp(HBP:"protein aggregation") association path(MESH:"Parkinson Disease") + act(complex(GO:"proteasome complex")) isA complex(GO:"proteasome complex") - pmid:21722302 + pubmed:17954934 - bp(HBP:"protein aggregation") association path(MESH:"Amyloidosis, Cerebral, with Spongiform Encephalopathy") + act(complex(GO:"proteasome complex")) negativeCorrelation p(HGNC:BAG1) - pmid:21722302 + pubmed:26041011 - bp(HBP:"protein aggregation") association path(MESH:"Brain Injuries, Traumatic") + act(complex(GO:"proteasome complex")) decreases a(CONSO:"Tau aggregates") - pmid:21722302 + pubmed:27181519 - bp(HBP:"protein aggregation") increases a(MESH:"Prion Proteins") + act(complex(GO:"proteasome complex")) negativeCorrelation complex(GO:"cytoplasmic stress granule") - pmid:21722302 + pubmed:27181519 - bp(HBP:"protein aggregation") increases a(HBP:"amyloid-beta aggregates") + complex(GO:"proteasome complex") decreases complex(GO:"cytoplasmic stress granule") - pmid:21722302 + pubmed:27181519 - p(MESH:"Huntingtin Protein", pmod(MESH:polyglutamine)) increases p(MESH:"PERK kinase") + complex(GO:"proteasome complex") increases deg(p(HGNC:TARDBP)) - + + + pubmed:22372633 + + composite(p(HGNC:HDAC6), p(HGNC:MAPT)) increases p(CONSO:"Tau aggregates") + @@ -104920,297 +106082,305 @@

Statements

- pmid:21722302 + pubmed:22372633 - composite(p(HGNC:ATG12), p(MESH:"Huntingtin Protein", pmod(MESH:polyglutamine))) increases bp(GO:autophagy) + p(HGNC:PRKN) positiveCorrelation bp(GO:mitophagy) - pmid:18930136 + pubmed:30515821 - p(HGNC:MAP1LC3B) increases complex(a(GO:autophagosome), p(HGNC:MAP1LC3B)) + act(p(HGNC:PRKN)) increases bp(GO:mitophagy) - pmid:18930136 + pubmed:30688256 - p(HGNC:MAP1LC3B) increases complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:MAP1LC3B)) + act(p(HGNC:PRKN)) increases bp(GO:mitophagy) - pmid:27260836 + pubmed:30688256 - p(HGNC:MAP1LC3B) negativeCorrelation p(HGNC:PICALM) + p(HGNC:PRKN) increases bp(GO:mitophagy) - pmid:18930136 + pubmed:21722302 - p(HGNC:ATG5) decreases path(HBP:Neurodegeneration) + p(HGNC:PRKN) association bp(GO:mitophagy) - pmid:26702100 + pubmed:21722302 - p(HGNC:ATG5) association bp(GO:autophagy) + p(HGNC:PRKN) increases bp(GO:mitophagy) - pmid:21722302 + pubmed:26968346 - p(HGNC:NUPR1) increases bp(GO:autophagy) + p(HGNC:PRKN) association bp(GO:mitophagy) - pmid:21722302 + pubmed:22908190 - bp(GO:"lysosomal protein catabolic process") increases deg(p(MESH:Proteins, pmod(HBP:misfolded))) + p(HGNC:PRKN) increases bp(GO:mitophagy) + + - pmid:29758300 + pubmed:30515821 - bp(GO:"lysosomal protein catabolic process") decreases a(GO:autolysosome) + p(HGNC:PRKN) negativeCorrelation path(DOID:"Parkinson's disease") + + - pmid:29758300 + pubmed:30515821 - bp(GO:"lysosomal protein catabolic process") negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:PRKN) increases path(MESH:Neuroprotection) - pmid:22908190 + pubmed:30515821 - bp(GO:"lysosomal protein catabolic process") negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:PRKN) decreases bp(GO:"programmed cell death") - pmid:29758300 + pubmed:30515821 - bp(GO:"lysosomal protein catabolic process") positiveCorrelation bp(GO:autophagy) + p(HGNC:PRKN) positiveCorrelation path(MESH:"Mitochondrial Dynamics") + + + + - pmid:22908190 + pubmed:30688256 - bp(GO:"lysosomal protein catabolic process") positiveCorrelation bp(GO:autophagy) + p(HGNC:PRKN) association path(MESH:"Parkinson Disease") - pmid:22908190 + pubmed:21722302 - bp(GO:"lysosomal protein catabolic process") negativeCorrelation act(p(HGNC:RAB5A)) + p(HGNC:PRKN) association path(MESH:"Parkinson Disease") - pmid:22908190 + pubmed:14556719 - bp(GO:"lysosomal protein catabolic process") increases bp(GO:"axonal transport") + p(HGNC:PRKN) positiveCorrelation path(MESH:"Parkinson Disease") - pmid:22908190 + pubmed:22908190 - bp(GO:"lysosomal protein catabolic process") negativeCorrelation bp(GO:endocytosis) + p(HGNC:PRKN) positiveCorrelation path(MESH:"Parkinson Disease") - pmid:22908190 + pubmed:27181519 - bp(GO:"lysosomal protein catabolic process") decreases path(HBP:Neurodegeneration) + p(HGNC:PRKN) association path(MESH:"Parkinson Disease") - pmid:22908190 + pubmed:30688256 - bp(GO:"lysosomal protein catabolic process") decreases path(HBP:Neurodegeneration) + act(p(HGNC:PRKN)) increases deg(a(MESH:Mitochondria)) - pmid:22908190 + pubmed:30688256 - bp(GO:"lysosomal protein catabolic process") decreases p(HGNC:MAP1LC3B) + p(HGNC:PRKN) increases act(a(MESH:Mitochondria)) - pmid:22908190 + pubmed:30688256 - bp(GO:"lysosomal protein catabolic process") decreases p(HGNC:SQSTM1) + p(HGNC:PRKN, loc(MESH:Mitochondria)) decreases act(p(HGNC:PINK1)) - pmid:22908190 + pubmed:30688256 - bp(GO:"lysosomal protein catabolic process") decreases p(MESH:Proteins, pmod(Ub)) + p(HGNC:PRKN) increases p(HGNC:MFN1, pmod(go:0016567 ! "protein ubiquitination")) - pmid:22908190 + pubmed:30688256 - bp(GO:"lysosomal protein catabolic process") increases deg(a(MESH:"Amyloid beta-Peptides")) + p(HGNC:PRKN) increases p(HGNC:MFN2, pmod(go:0016567 ! "protein ubiquitination")) - pmid:22908190 + pubmed:30688256 - bp(GO:"lysosomal protein catabolic process") increases deg(a(CHEBI:"amyloid-beta")) + p(HGNC:PRKN) decreases bp(GO:"mitochondrial fusion") - pmid:22908190 + pubmed:30688256 - bp(GO:"lysosomal protein catabolic process") increases deg(a(CHEBI:"amyloid-beta")) + p(HGNC:PRKN) increases deg(p(HGNC:MFN1)) - pmid:22908190 + pubmed:30688256 - bp(GO:"lysosomal protein catabolic process") decreases a(CHEBI:"amyloid-beta") + p(HGNC:PRKN) increases deg(p(HGNC:MFN2)) - pmid:22908190 + pubmed:30688256 - bp(GO:"lysosomal protein catabolic process") increases bp(GO:learning) + p(HGNC:PRKN) decreases bp(GO:"apoptotic process") - pmid:22908190 + pubmed:30688256 - bp(GO:"lysosomal protein catabolic process") increases bp(GO:memory) + p(HGNC:PRKN) decreases path(MESH:"Oxidative Stress") - pmid:21722302 + pubmed:30688256 - path(MESH:"Amyloidosis, Cerebral, with Spongiform Encephalopathy") association bp(HBP:"protein aggregation") + act(p(HGNC:PRKN)) increases deg(p(HGNC:RHOT1)) - pmid:21722302 + pubmed:21722302 - path(HP:"Senile plaques") association path(MESH:"Alzheimer Disease") + p(HGNC:PRKN) increases bp(GO:"proteasomal protein catabolic process") - pmid:21722302 + pubmed:22908190 - path(HP:"Senile plaques") increases a(HBP:"amyloid-beta aggregates") + p(HGNC:PRKN) increases bp(GO:"proteasomal protein catabolic process") - pmid:21722302 + pubmed:21722302 - path(HP:"Senile plaques") increases a(MESH:"Neurofibrillary Tangles") + p(HGNC:PRKN) increases bp(MESH:"Cell Survival") - pmid:21722302 + pubmed:21722302 - path(HP:"Senile plaques") increases a(MESH:"Neurofibrillary Tangles") + p(HGNC:PRKN) negativeCorrelation bp(GO:"JNK cascade") - pmid:21722302 + pubmed:21722302 - path(HP:"Senile plaques") association path(MESH:"Neurodegenerative Diseases") + p(HGNC:PRKN) increases p(HGNCGENEFAMILY:"Voltage dependent anion channels", pmod(go:0016567 ! "protein ubiquitination")) @@ -105219,55 +106389,56 @@

Statements

- pmid:21722302 + pubmed:21722302 - p(PFAM:Presenilin) isA complex(GO:"ER membrane protein complex") + p(HGNC:PRKN) regulates bp(MESH:"Protein Stability") - pmid:21722302 + pubmed:26968346 - p(PFAM:Presenilin) association p(HGNC:ERN1) + p(HGNC:PRKN) increases tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) - pmid:21722302 + pubmed:26968346 - p(PFAM:Presenilin) association p(MESH:"PERK kinase") + p(HGNC:PRKN) increases act(p(HGNC:TFEB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) + + - pmid:21722302 + pubmed:27299292 - p(PFAM:Presenilin) decreases p(MESH:"PERK kinase", pmod(Ph)) + p(HGNC:PRKN) association composite(p(HGNC:MITF), p(HGNC:TFE3), p(HGNC:TFEB)) + + - pmid:21722302 + pubmed:14556719 - p(PFAM:Presenilin) decreases p(HGNC:EIF2A, pmod(Ph)) + p(HGNC:PRKN) association p(HGNC:PSMD4) - - - pmid:21722302 - - p(PFAM:Presenilin, var("?")) association path(MESH:"Alzheimer Disease") - + + + @@ -105275,2190 +106446,2192 @@

Statements

- pmid:21722302 + pubmed:14556719 - p(MESH:"Presenilin-1", var("?")) increases bp(MESH:Apoptosis) + p(HGNC:PRKN) association bp(MESH:"Synaptic Transmission") - pmid:21722302 + pubmed:14556719 - p(MESH:"Presenilin-1", var("?")) decreases p(HGNC:ERN1) + p(HGNC:PRKN) negativeCorrelation a(MESH:"Dopaminergic Neurons") - pmid:21722302 + pubmed:14556719 - p(MESH:"Presenilin-1", var("?")) decreases r(MESH:"molecular chaperone GRP78") + p(HGNC:PRKN) increases p(HGNC:SEPT5, pmod(go:0016567 ! "protein ubiquitination")) - pmid:21722302 + pubmed:14556719 - p(MESH:"Presenilin-1", var("?")) decreases r(HGNC:XBP1) + p(HGNC:PRKN) association p(HGNC:GPR37) + + - pmid:21722302 + pubmed:14556719 - p(MESH:"Presenilin-1", var("?")) increases p(HGNC:APP, frag("672_713")) + p(HGNC:PRKN) decreases bp(GO:"response to unfolded protein") - pmid:21722302 + pubmed:14556719 - p(MESH:"Presenilin-1", var("?")) decreases bp(GO:"calcium ion homeostasis") + p(HGNC:PRKN) decreases act(p(HGNC:SNCA)) - pmid:21722302 + pubmed:14556719 - p(MESH:"Presenilin-1", var("?")) increases tloc(a(CHEBI:"calcium cation"), fromLoc(GO:"endoplasmic reticulum"), toLoc(GO:cytoplasm)) + p(HGNC:PRKN) regulates p(HGNC:SNCA) - pmid:21722302 + pubmed:14556719 - p(MESH:"PERK kinase", pmod(Ph)) increases bp(HBP:"protein aggregation") + p(HGNC:PRKN) association p(HGNC:SNCA, pmod(go:0006493 ! "protein O-linked glycosylation")) - pmid:21722302 + pubmed:14556719 - p(HGNC:EIF2A, pmod(Ph)) increases bp(HBP:"protein aggregation") + p(HGNC:PRKN) increases p(HGNC:SNCAIP, pmod(go:0016567 ! "protein ubiquitination")) - pmid:27181519 + pubmed:14556719 - p(HGNC:EIF2A, pmod(Ph)) increases complex(GO:"cytoplasmic stress granule") + p(HGNC:PRKN) increases p(HGNC:SNCAIP, pmod(go:0016567 ! "protein ubiquitination")) - pmid:27181519 + pubmed:14556719 - p(HGNC:EIF2A, pmod(Ph)) decreases bp(GO:translation) + p(HGNC:PRKN) increases tloc(p(HGNC:SNCAIP, pmod(go:0016567 ! "protein ubiquitination")), fromLoc(GO:cytosol), toLoc(MESH:"Inclusion Bodies")) - pmid:21722302 + pubmed:14556719 - r(MESH:"molecular chaperone GRP78") association bp(MESH:"Endoplasmic Reticulum Stress") + p(HGNC:PRKN) increases act(complex(GO:"proteasome complex")) - pmid:21722302 + pubmed:14556719 - p(HGNC:UBQLN1) negativeCorrelation complex(FPLX:"Gamma_secretase") + p(HGNC:PRKN) decreases act(p(HGNC:CASP12)) + + - pmid:21722302 + pubmed:14556719 - p(HGNC:UBQLN1) regulates p(HGNC:APP) + p(HGNC:PRKN) association p(HGNC:CCNE1) - pmid:21722302 + pubmed:14556719 - p(HGNC:UBQLN1) regulates a(CHEBI:"amyloid-beta") + p(HGNC:PRKN) decreases p(HGNC:CCNE1) + + - pmid:22908190 + pubmed:14556719 - p(HGNC:UBQLN1) association path(MESH:"Alzheimer Disease") + p(HGNC:PRKN) decreases bp(GO:"neuron apoptotic process") - pmid:22908190 + pubmed:14556719 - p(HGNC:UBQLN1) increases complex(a(GO:"proteasome complex"), p(HGNC:UBQLN1)) + p(HGNC:PRKN) decreases bp(GO:"cell death") + + - pmid:22908190 + pubmed:14556719 - p(HGNC:UBQLN1) increases complex(p(HGNC:UBQLN1), p(MESH:Proteins, pmod(Ub))) + p(HGNC:PRKN) increases p(HGNC:SYT11, pmod(go:0016567 ! "protein ubiquitination")) - pmid:22908190 + pubmed:14556719 - p(HGNC:UBQLN1) regulates deg(p(HGNC:PSEN1)) + p(HGNC:PRKN) association a(GO:"actin filament") - - - pmid:21722302 + pubmed:14556719 - path(HP:Dyskinesia) prognosticBiomarkerFor path(MESH:"Parkinson Disease") + p(HGNC:PRKN) regulates act(a(MESH:Actins)) - pmid:21722302 + pubmed:14556719 - path(HP:"Postural instability") prognosticBiomarkerFor path(MESH:"Parkinson Disease") + p(HGNC:PRKN) association p(HGNC:SNCA, pmod(go:0006486 ! "protein glycosylation")) - pmid:21722302 + pubmed:23528736 - path(HP:"Resting tremor") prognosticBiomarkerFor path(MESH:"Parkinson Disease") + p(HGNC:PRKN) association path(MESH:"Neurodegenerative Diseases") - pmid:21722302 + pubmed:23528736 - path(DOID:"olfactory nerve disease") prognosticBiomarkerFor path(MESH:"Parkinson Disease") + p(HGNC:PRKN) association path(MESH:"Alzheimer Disease") - pmid:21722302 + pubmed:27181519 - path(HBP:"Gastrointestinal dysfunctions") prognosticBiomarkerFor path(MESH:"Parkinson Disease") + p(HGNC:PRKN) increases complex(a(GO:mitochondrion), p(HGNC:OPTN)) - - - - - - - - - - - pmid:21722302 + pubmed:30837838 - p(MESH:"alpha-Synuclein") regulates bp(MESH:"Protein Stability") + p(HGNC:PRKN) increases p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination", Lys, 48)) - pmid:21722302 + pubmed:30837838 - a(GO:"Lewy neurite") biomarkerFor path(MESH:"Parkinson Disease") + p(HGNC:PRKN) increases p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination", Lys, 63)) - pmid:21722302 + pubmed:22372633 - p(MESH:"alpha-Synuclein", pmod(HBP:misfolded)) increases a(HBP:"alpha-synuclein aggregates") + bp(GO:mitophagy) positiveCorrelation p(HGNC:PRKN) - pmid:21722302 + pubmed:21722302 - path(DOID:"autosomal dominant Parkinson's disease 1") association g(MESH:"alpha-Synuclein") + bp(GO:mitophagy) association p(HGNC:PRKN) - pmid:21722302 + pubmed:26968346 - path(DOID:"autosomal dominant Parkinson's disease 1") association g(MESH:"UCHL1 protein, human") + bp(GO:mitophagy) association p(HGNC:PRKN) - pmid:21722302 + pubmed:30515821 - path(DOID:"autosomal dominant Parkinson's disease 1") association g(MESH:"LRRK2 protein, human") + bp(GO:mitophagy) regulates path(MESH:"Mitochondrial Dynamics") - pmid:21722302 + pubmed:30688256 - path(DOID:"autosomal dominant Parkinson's disease 1") association p(HGNC:UCHL1, var("?")) + bp(GO:mitophagy) isA bp(GO:autophagy) - pmid:21722302 + pubmed:30688256 - g(MESH:"alpha-Synuclein") association path(DOID:"autosomal dominant Parkinson's disease 1") + bp(GO:mitophagy) increases deg(a(MESH:Mitochondria)) - pmid:21722302 + pubmed:30688256 - g(MESH:"UCHL1 protein, human") association path(DOID:"autosomal dominant Parkinson's disease 1") + bp(GO:mitophagy) decreases path(HBP:"mitochondrial dysfunction") - pmid:21722302 + pubmed:30688256 - g(MESH:"LRRK2 protein, human") association path(DOID:"autosomal dominant Parkinson's disease 1") + bp(GO:mitophagy) decreases p(HGNC:PRKN, var("?")) - pmid:21722302 + pubmed:30688256 - path(DOID:"autosomal recessive Parkinson's disease 14") association g(MESH:"parkin protein") + bp(GO:mitophagy) association a(CHEBI:"reactive oxygen species") - pmid:21722302 + pubmed:30688256 - path(DOID:"autosomal recessive Parkinson's disease 14") association g(HGNC:PINK1) + bp(GO:mitophagy) association bp(GO:"lipid oxidation") - pmid:21722302 + pubmed:30688256 - path(DOID:"autosomal recessive Parkinson's disease 14") association g(HGNC:PARK7) + bp(GO:mitophagy) association p(HGNC:HTT) - pmid:21722302 + pubmed:30688256 - path(DOID:"autosomal recessive Parkinson's disease 14") association g(HGNC:ATP13A2) + bp(GO:mitophagy) negativeCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") - pmid:21722302 + pubmed:30688256 - path(DOID:"autosomal recessive Parkinson's disease 14") association p(MESH:"parkin protein") + bp(GO:mitophagy) decreases bp(GO:"cell death") - pmid:21722302 + pubmed:30688256 - g(MESH:"parkin protein") association path(DOID:"autosomal recessive Parkinson's disease 14") + bp(GO:mitophagy) association p(HGNC:SOD1, var("?")) - pmid:21722302 + pubmed:21722302 - g(HGNC:PINK1) association path(DOID:"autosomal recessive Parkinson's disease 14") + bp(GO:mitophagy) increases path(MESH:"Parkinson Disease") - pmid:21722302 + pubmed:26968346 - g(HGNC:PARK7) association path(DOID:"autosomal recessive Parkinson's disease 14") + bp(GO:mitophagy) association p(HGNC:PINK1) - - - pmid:21722302 + pubmed:26968346 - g(HGNC:ATP13A2) association path(DOID:"autosomal recessive Parkinson's disease 14") + bp(GO:mitophagy) association p(HGNC:TFEB) - pmid:21722302 + pubmed:27299292 - p(MESH:"alpha-Synuclein", pmod(Ph)) increases p(MESH:"alpha-Synuclein", pmod(HBP:misfolded)) + bp(GO:mitophagy) positiveCorrelation composite(p(HGNC:ATG5), p(HGNC:ATG9A), p(HGNC:MITF), p(HGNC:PINK1), p(HGNC:PRKN), p(HGNC:TFE3), p(HGNC:TFEB)) - pmid:21722302 + pubmed:18930136 - p(MESH:"alpha-Synuclein", pmod(NO)) increases p(MESH:"alpha-Synuclein", pmod(HBP:misfolded)) + bp(GO:mitophagy) isA bp(GO:macroautophagy) - pmid:21722302 + pubmed:30116051 - p(MESH:"alpha-Synuclein", var("?")) increases path(DOID:"autosomal dominant Parkinson's disease 1") + bp(GO:mitophagy) negativeCorrelation g(HGNC:PSEN1, var("?")) - pmid:21722302 + pubmed:22372633 - p(MESH:"alpha-Synuclein", var("?")) decreases bp(MESH:"Protein Stability") + complex(a(MESH:Mitochondria), p(HGNC:HDAC6), p(HGNC:SQSTM1)) increases deg(a(MESH:Mitochondria)) - pmid:21722302 + pubmed:22372633 - p(MESH:"alpha-Synuclein", var("p.Ala53Thr")) increases bp(MESH:"Unfolded Protein Response") + path(DOID:"retinal degeneration") negativeCorrelation p(HGNC:HDAC6) - + + + pubmed:22372633 + + path(DOID:"retinal degeneration") positiveCorrelation p(HGNC:SNCA, var("?")) + - pmid:21722302 + pubmed:22372633 - composite(p(HGNC:EIF2A, pmod(Ph)), p(MESH:"alpha-Synuclein", var("p.Ala53Thr"))) increases bp(MESH:"Cell Death") + bp(MESH:Locomotion) positiveCorrelation p(HGNC:HDAC6) - pmid:14556719 + pubmed:23516100 - bp(GO:"protein catabolic process") increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + path(DOID:"Huntington's disease") increases tloc(p(HGNC:HTT, frag("?")), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) - pmid:23746257 + pubmed:23516100 - bp(GO:"protein catabolic process") association act(p(FPLX:HSPA)) + path(DOID:"Huntington's disease") positiveCorrelation p(HGNC:HTT, frag("?")) - pmid:21722302 + pubmed:23516100 - p(HGNC:UCHL1, var("?")) association path(DOID:"autosomal dominant Parkinson's disease 1") + path(DOID:"Huntington's disease") negativeCorrelation bp(GO:"calcium ion homeostasis") - pmid:21722302 + pubmed:20556492 - p(HGNC:UCHL1, var("?")) decreases bp(GO:"chaperone-mediated autophagy") + path(DOID:"Huntington's disease") decreases bp(GO:"calcium ion homeostasis") - pmid:14556719 + pubmed:23516100 - p(HGNC:UCHL1, var("?")) association path(MESH:"Parkinson Disease") + path(DOID:"Huntington's disease") decreases act(p(HGNCGENEFAMILY:Calpains)) - pmid:14556719 + pubmed:23516100 - p(HGNC:UCHL1, var("?")) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + path(DOID:"Huntington's disease") increases p(HGNC:CAPN1) - pmid:23528736 + pubmed:23516100 - p(HGNC:UCHL1, var("?")) association path(MESH:"Neurodegenerative Diseases") + path(DOID:"Huntington's disease") increases p(HGNC:CAPN5) - pmid:23528736 + pubmed:23516100 - p(HGNC:UCHL1, var("?")) association path(MESH:"Alzheimer Disease") + path(DOID:"Huntington's disease") increases p(HGNC:CAPN7) - pmid:21722302 + pubmed:23516100 - bp(GO:"chaperone-mediated autophagy") association p(HGNC:UCHL1) + path(DOID:"Huntington's disease") increases p(HGNC:CAPN10) - pmid:29758300 + pubmed:23516100 - bp(GO:"chaperone-mediated autophagy") decreases a(HBP:"protein aggregates") + path(DOID:"Huntington's disease") increases act(p(HGNC:CASP6)) - pmid:29758300 + pubmed:23516100 - bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:MAPT)) + path(DOID:"Huntington's disease") causesNoChange act(p(HGNC:CASP3)) - pmid:22908190 + pubmed:20556492 - bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:MAPT)) + path(DOID:"Huntington's disease") decreases bp(GO:"glucose import") - pmid:30116051 + pubmed:20556492 - bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:MAPT)) + path(DOID:"Huntington's disease") increases a(CHEBI:lactate) - pmid:30116051 + pubmed:20556492 - bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:MAPT)) + path(DOID:"Huntington's disease") negativeCorrelation bp(GO:"regulation of succinate dehydrogenase activity") - pmid:29758300 + pubmed:20556492 - bp(GO:"chaperone-mediated autophagy") association p(HGNC:SNCA) + path(DOID:"Huntington's disease") negativeCorrelation bp(GO:"tricarboxylic acid cycle") - pmid:29758300 + pubmed:20556492 - bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:SNCA)) + path(DOID:"Huntington's disease") decreases p(HGNCGENEFAMILY:"Mitochondrial complex II: succinate dehydrogenase subunits") - pmid:18930136 + pubmed:20556492 - bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:SNCA)) + path(DOID:"Huntington's disease") decreases act(p(HGNCGENEFAMILY:"Mitochondrial complex III: ubiquinol-cytochrome c reductase complex subunits")) - pmid:18930136 + pubmed:20556492 - bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:SNCA)) + path(DOID:"Huntington's disease") decreases act(p(HGNCGENEFAMILY:"Mitochondrial complex IV: cytochrome c oxidase subunits")) - pmid:18930136 + pubmed:20556492 - bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:SNCA)) + path(DOID:"Huntington's disease") decreases a(EFO:"mitochondrial DNA") - pmid:30116051 + pubmed:20556492 - bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:SNCA)) + path(DOID:"Huntington's disease") decreases bp(GO:"ATP biosynthetic process") - pmid:30116051 + pubmed:20556492 - bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:SNCA)) + path(DOID:"Huntington's disease") decreases bp(GO:"ATP biosynthetic process") - pmid:29758300 + pubmed:20556492 - bp(GO:"chaperone-mediated autophagy") association p(HGNC:SNCA, var("?")) + path(DOID:"Huntington's disease") increases bp(GO:"negative regulation of mitochondrial membrane potential") - pmid:22908190 + pubmed:20556492 - bp(GO:"chaperone-mediated autophagy") increases tloc(a(MESH:Proteins), fromLoc(GO:cytosol), toLoc(GO:"lysosomal lumen")) + path(DOID:"Huntington's disease") negativeCorrelation bp(MESH:"Energy Metabolism") - pmid:18930136 + pubmed:20556492 - bp(GO:"chaperone-mediated autophagy") increases tloc(a(MESH:Proteins), fromLoc(GO:cytoplasm), toLoc(GO:"lysosomal lumen")) + path(DOID:"Huntington's disease") increases path(DOID:"muscular atrophy") - pmid:18930136 + pubmed:20556492 - bp(GO:"chaperone-mediated autophagy") association p(HGNC:HSPA8) + path(DOID:"Huntington's disease") decreases bp(GO:"membrane depolarization") - pmid:24563850 + pubmed:23393546 - bp(GO:"chaperone-mediated autophagy") decreases path(MESH:"Protein Aggregation, Pathological") + path(DOID:"Huntington's disease") negativeCorrelation bp(GO:"MAPK cascade") - pmid:30116051 + pubmed:23393546 - bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:TARDBP)) + path(DOID:"Huntington's disease") negativeCorrelation bp(GO:"MAPK cascade") - pmid:30116051 + pubmed:23393546 - bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:APP)) + path(DOID:"Huntington's disease") decreases bp(GO:"motor behavior") - pmid:30116051 + pubmed:23393546 - bp(GO:"chaperone-mediated autophagy") causesNoChange deg(a(CHEBI:"amyloid-beta polypeptide 42")) + path(DOID:"Huntington's disease") decreases p(HGNC:PPP1R1B) - pmid:30116051 + pubmed:23393546 - bp(GO:"chaperone-mediated autophagy") causesNoChange deg(p(HGNC:HTT)) + path(DOID:"Huntington's disease") association p(HGNC:DRD2) - pmid:30116051 + pubmed:23393546 - bp(GO:"chaperone-mediated autophagy") causesNoChange deg(p(HGNC:HTT, var("?"))) + path(DOID:"Huntington's disease") association p(HGNC:DRD2) - pmid:30116051 + pubmed:23393546 - bp(GO:"chaperone-mediated autophagy") causesNoChange deg(p(HGNC:HTT, frag("?"))) + path(DOID:"Huntington's disease") association p(HGNC:GAD2) - pmid:30116051 + pubmed:23393546 - bp(GO:"chaperone-mediated autophagy") increases act(p(HGNC:MEF2D)) + path(DOID:"Huntington's disease") association p(HGNC:GAD2) - pmid:29024336 + pubmed:23393546 - bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt)) + path(DOID:"Huntington's disease") association p(HGNC:GAD1) - pmid:29024336 + pubmed:23393546 - bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt)) + path(DOID:"Huntington's disease") association p(HGNC:GAD1) - pmid:29024336 + pubmed:23393546 - bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt)) + path(DOID:"Huntington's disease") association p(HGNC:GRIA2) - pmid:29024336 + pubmed:23393546 - bp(GO:"chaperone-mediated autophagy") increases deg(a(HBP:HBP00053)) + path(DOID:"Huntington's disease") association p(HGNC:GRIA3) - pmid:29024336 + pubmed:23393546 - bp(GO:"chaperone-mediated autophagy") increases deg(a(HBP:HBP00053)) + path(DOID:"Huntington's disease") association p(HGNC:HTR1B) - pmid:29024336 + pubmed:23393546 - bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt, var("p.Ala152Thr"))) + path(DOID:"Huntington's disease") association p(HGNC:HTR1B) - pmid:29024336 + pubmed:23393546 - bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt, var("p.Ala152Thr"))) + path(DOID:"Huntington's disease") decreases p(HGNC:GRM2) - pmid:29024336 + pubmed:23393546 - bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt, var("p.Ala152Thr"))) + path(DOID:"Huntington's disease") decreases p(HGNC:GRM3) - pmid:29024336 + pubmed:23393546 - bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt, var("p.Pro301Leu"))) + path(DOID:"Huntington's disease") increases bp(GO:"negative regulation of cell volume") - pmid:29024336 + pubmed:26968346 - bp(GO:"chaperone-mediated autophagy") causesNoChange deg(p(MGI:Mapt, var("p.Pro301Leu"))) + path(DOID:"Huntington's disease") decreases r(HGNC:TFEB) - pmid:29024336 + pubmed:26968346 - bp(GO:"chaperone-mediated autophagy") decreases path(MESH:"Proteostasis Deficiencies") + path(DOID:"Huntington's disease") decreases bp(GO:autophagy) - pmid:25374103 + pubmed:26968346 - bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:MAPT, pmod(HBP:misfolded))) + path(DOID:"Huntington's disease") decreases bp(GO:"lysosomal protein catabolic process") - pmid:29311797 + pubmed:27299292 - bp(GO:"chaperone-mediated autophagy") negativeCorrelation path(MESH:"Neurodegenerative Diseases") + path(DOID:"Huntington's disease") increases p(HGNC:TFEB) - pmid:29311797 + pubmed:27299292 - bp(GO:"chaperone-mediated autophagy") association p(FPLX:HSP90) + path(DOID:"Huntington's disease") positiveCorrelation p(CONSO:"huntingtin aggregates") - pmid:29311797 + pubmed:23384725 - bp(GO:"chaperone-mediated autophagy") association p(HGNC:STIP1) + path(DOID:"Huntington's disease") association composite(a(MESH:"Inclusion Bodies"), p(HGNC:TARDBP)) - pmid:21722302 + pubmed:22372633 - p(MESH:"parkin protein") association path(DOID:"autosomal recessive Parkinson's disease 14") + p(HGNC:TARDBP, var("?")) increases complex(p(HGNC:TARDBP), r(HGNC:HDAC6), loc(GO:"cytoplasmic stress granule")) - pmid:21722302 + pubmed:30688256 - p(MESH:"parkin protein") increases bp(GO:"proteasomal protein catabolic process") + p(HGNC:TARDBP, var("?")) increases a(CHEBI:"reactive oxygen species") - pmid:21722302 + pubmed:30688256 - p(MESH:"parkin protein") increases bp(MESH:"Cell Survival") + p(HGNC:TARDBP, var("?")) increases path(MESH:"Mitochondrial Diseases") - pmid:21722302 + pubmed:30688256 - p(MESH:"parkin protein") negativeCorrelation bp(GO:"JNK cascade") + p(HGNC:TARDBP, var("?")) increases p(HGNC:NFE2L2) - - - pmid:21722302 + pubmed:30837838 - p(MESH:"parkin protein") association bp(GO:mitophagy) + p(HGNC:TARDBP, var("?")) increases p(HGNC:NFE2L2, loc(GO:nucleus)) - pmid:21722302 + pubmed:21722302 - p(MESH:"parkin protein") increases bp(GO:mitophagy) + p(HGNC:TARDBP, var("?")) biomarkerFor path(MESH:"Amyotrophic Lateral Sclerosis") - pmid:21722302 + pubmed:29980653 - p(MESH:"parkin protein") association path(MESH:"Parkinson Disease") + p(HGNC:TARDBP, var("?")) positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") - pmid:21722302 + pubmed:30837838 - p(MESH:"parkin protein") increases p(HGNCGENEFAMILY:"Voltage dependent anion channels", pmod(Ub)) + p(HGNC:TARDBP, var("?")) increases path(MESH:"Amyotrophic Lateral Sclerosis") - pmid:21722302 + pubmed:21722302 - p(MESH:"parkin protein") regulates bp(MESH:"Protein Stability") + p(HGNC:TARDBP, var("?")) biomarkerFor path(MESH:"Frontotemporal Lobar Degeneration") - pmid:22908190 + pubmed:30837838 - bp(GO:"proteasomal protein catabolic process") negativeCorrelation bp(GO:autophagy) + p(HGNC:TARDBP, var("?")) increases path(MESH:"Frontotemporal Lobar Degeneration") - pmid:22908190 + pubmed:29980653 - bp(GO:"proteasomal protein catabolic process") decreases a(MESH:Proteins) + p(HGNC:TARDBP, var("?")) positiveCorrelation path(MESH:"Frontotemporal Dementia") - pmid:22908190 + pubmed:27181519 - bp(GO:"proteasomal protein catabolic process") association p(HGNC:SQSTM1) + p(HGNC:TARDBP, var("?")) increases path(DOID:"amyotrophic lateral sclerosis") - pmid:24027553 + pubmed:27181519 - bp(GO:"proteasomal protein catabolic process") negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:TARDBP, var("?")) positiveCorrelation path(DOID:"amyotrophic lateral sclerosis") - pmid:26631930 + pubmed:27181519 - bp(GO:"proteasomal protein catabolic process") increases deg(p(HGNC:MAPT)) + p(HGNC:TARDBP, var("?")) negativeCorrelation bp(GO:autophagy) - pmid:29626319 + pubmed:30837838 - bp(GO:"proteasomal protein catabolic process") increases deg(p(HGNC:MAPT)) + p(HGNC:TARDBP, var("?")) decreases path(MESH:"RNA Transport") - pmid:26631930 + pubmed:30837838 - bp(GO:"proteasomal protein catabolic process") decreases deg(p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356))) + p(HGNC:TARDBP, var("?")) increases path(MESH:"Protein Aggregation, Pathological") - pmid:26631930 + pubmed:30837838 - bp(GO:"proteasomal protein catabolic process") increases deg(p(HGNC:MAPT, pmod(Ub))) + p(HGNC:TARDBP, var("?")) negativeCorrelation bp(GO:"regulation of cytoplasmic transport") - pmid:26631930 + pubmed:30837838 - bp(GO:"proteasomal protein catabolic process") increases deg(p(HGNC:MAPT, pmod(UbK63))) + p(HGNC:TARDBP, var("?")) decreases path(MESH:"Protein Stability") - pmid:21722302 + pubmed:30837838 - bp(GO:"negative regulation of ubiquitin protein ligase activity") increases p(MESH:Proteins, pmod(HBP:misfolded)) + p(HGNC:TARDBP, var("?")) decreases path(MESH:Proteolysis) - pmid:21722302 + pubmed:30837838 - p(MESH:"parkin protein", var("?")) increases bp(MESH:"Cell Death") + p(HGNC:TARDBP, var("?")) decreases path(MESH:"Protein Binding") - pmid:21722302 + pubmed:30837838 - p(MESH:"parkin protein", var("?")) decreases bp(GO:"parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization") + p(HGNC:TARDBP, var("?")) decreases complex(p(HGNC:ATG7), p(HGNC:TARDBP)) - pmid:21722302 + pubmed:30837838 - p(MESH:"parkin protein", var("?")) decreases bp(MESH:"Protein Stability") + p(HGNC:TARDBP, var("?")) decreases path(MESH:"Mitochondrial Size") - pmid:21722302 + pubmed:30837838 - bp(GO:mitophagy) association p(MESH:"parkin protein") + p(HGNC:TARDBP, var("?")) decreases path(MESH:Movement) - pmid:21722302 + pubmed:30837838 - bp(GO:mitophagy) increases p(MESH:"parkin protein") + p(HGNC:TARDBP, var("?")) decreases bp(GO:"mitochondrial transport") - pmid:21722302 + pubmed:30837838 - bp(GO:mitophagy) increases path(MESH:"Parkinson Disease") + p(HGNC:TARDBP, var("?")) decreases bp(GO:"mitochondrion distribution") - pmid:18930136 + pubmed:30837838 - bp(GO:mitophagy) isA bp(GO:macroautophagy) + p(HGNC:TARDBP, var("?")) increases path(MESH:"Oxidative Stress") - pmid:30116051 + pubmed:30837838 - bp(GO:mitophagy) negativeCorrelation g(HGNC:PSEN1, var("?")) + p(HGNC:TARDBP, var("?")) decreases complex(p(HGNC:RMDN3), p(HGNC:VAPB)) - pmid:21722302 + pubmed:30837838 - bp(GO:"mitochondrial depolarization") increases p(HGNC:PINK1) + p(HGNC:TARDBP, var("?")) decreases bp(GO:"positive regulation of mitochondrial calcium ion concentration") - pmid:21722302 + pubmed:30837838 - p(HGNC:PINK1) increases p(MESH:"parkin protein") + p(HGNC:TARDBP, var("?")) negativeCorrelation bp(GO:"axonal transport of mitochondrion") - - - pmid:21722302 + pubmed:30837838 - p(HGNC:PINK1) association bp(MESH:"Protein Stability") + p(HGNC:TARDBP, var("?")) decreases p(HGNC:SS18) - pmid:21722302 + pubmed:22372633 - p(HGNC:PINK1) regulates bp(MESH:"Protein Stability") + p(HGNC:FUS, var("?")) increases complex(p(HGNC:FUS), r(HGNC:HDAC6), loc(GO:"cytoplasmic stress granule")) - pmid:21722302 + pubmed:30935091 - p(HGNC:PINK1) decreases bp(MESH:"Oxidative Stress") + p(HGNC:FUS, var("?")) increases p(HGNC:FUS, loc(GO:cytoplasm)) - pmid:21722302 + pubmed:30935091 - p(HGNC:PINK1) decreases path(HBP:"mitochondrial dysfunction") + p(HGNC:FUS, var("?")) negativeCorrelation bp(GO:"axonal transport") - pmid:21722302 + pubmed:27181519 - p(HGNC:PINK1) decreases bp(MESH:Apoptosis) + p(HGNC:FUS, var("?")) increases path(DOID:"amyotrophic lateral sclerosis") - pmid:21722302 + pubmed:27181519 - p(HGNCGENEFAMILY:"Voltage dependent anion channels", pmod(Ub)) increases bp(MESH:"Mitochondrial Degradation") + p(HGNC:FUS, var("?")) positiveCorrelation path(DOID:"amyotrophic lateral sclerosis") - - - pmid:21722302 + pubmed:27181519 - bp(GO:"parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization") association path(MESH:"Parkinson Disease") + p(HGNC:FUS, var("?")) negativeCorrelation bp(GO:autophagy) - pmid:21722302 + pubmed:27181519 - p(HGNC:PINK1, var("?")) increases path(DOID:"autosomal recessive Parkinson's disease 14") + p(HGNC:FUS, var("?")) decreases bp(GO:autophagy) - pmid:21722302 + pubmed:27181519 - p(HGNC:PINK1, var("?")) decreases bp(MESH:"Protein Stability") + p(HGNC:FUS, var("?")) decreases bp(GO:"motor neuron apoptotic process") - pmid:30116051 + pubmed:27181519 - p(HGNC:PINK1, var("?")) association path(MESH:"Parkinson Disease") + p(HGNC:FUS, var("?")) increases bp(GO:"cell death") - pmid:30116051 + pubmed:27181519 - p(HGNC:PINK1, var("?")) decreases bp(GO:mitophagy) + p(HGNC:FUS, var("?")) decreases a(MESH:Neurites) - pmid:21722302 + pubmed:22372633 - bp(MESH:"Protein Stability") association p(HGNC:PINK1) + path(MESH:"Muscle Denervation") positiveCorrelation p(HGNC:HDAC6) - pmid:21722302 + pubmed:22372633 - p(HGNC:PARK7, var("?")) association path(MESH:"Parkinson Disease") + path(MESH:"Muscle Denervation") negativeCorrelation a(MESH:Axons) + + - pmid:21722302 + pubmed:30935091 - p(HGNC:PARK7, var("?")) increases bp(MESH:"Oxidative Stress") + p(HGNC:HSPB1) decreases bp(MESH:"Oxidative Stress") - pmid:21722302 + pubmed:30935091 - p(HGNC:PARK7, var("?")) increases bp(MESH:"Endoplasmic Reticulum Stress") + p(HGNC:HSPB1) increases bp(MESH:"Cell Survival") - pmid:21722302 + pubmed:27491084 - p(HGNC:PARK7, var("?")) decreases bp(MESH:"Protein Stability") + p(HGNC:HSPB1) association a(CONSO:"amyloid-beta aggregates") + + + + - pmid:24563850 + pubmed:21882945 - bp(GO:"detection of redox state") association a(CHEBI:radical) + p(HGNC:HSPB1) increases bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") - pmid:21722302 + pubmed:21882945 - a(MESH:Paraquat) isA a(CHEBI:herbicide) + p(HGNC:HSPB1) increases bp(GO:"proteasomal protein catabolic process") - pmid:21722302 + pubmed:21882945 - a(MESH:Paraquat) association path(MESH:"Parkinson Disease") + p(HGNC:HSPB1) increases bp(GO:autophagy) + + - pmid:21722302 + pubmed:21882945 - a(MESH:Paraquat) increases p(MESH:"molecular chaperone GRP78") + p(HGNC:HSPB1) directlyIncreases complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) - pmid:21722302 + pubmed:14963027 - a(MESH:Paraquat) increases complex(GO:"CHOP-C/EBP complex") + p(HGNC:HSPB1) increases complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) + + - pmid:21722302 + pubmed:21882945 - a(MESH:Paraquat) increases act(p(HGNC:ERN1)) + p(HGNC:HSPB1) directlyIncreases complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) - pmid:21722302 + pubmed:21882945 - a(MESH:Paraquat) increases act(p(MESH:"ASK1 protein, S cerevisiae")) + p(HGNC:HSPB1) increases p(HGNC:MAPT) - pmid:21722302 + pubmed:21882945 - a(MESH:Paraquat) increases bp(GO:"JNK cascade") + p(HGNC:HSPB1) decreases p(HGNC:MAPT) - - - + + + pubmed:21882945 + + p(HGNC:HSPB1) directlyIncreases complex(a(MESH:"Neurofibrillary Tangles"), p(HGNC:HSPB1)) + - pmid:21722302 + pubmed:21882945 - a(MESH:Hydroxydopamines) increases path(MESH:"Parkinson Disease") + p(HGNC:HSPB1) positiveCorrelation bp(GO:"long-term synaptic potentiation") - pmid:21722302 + pubmed:14963027 - a(MESH:Hydroxydopamines) directlyIncreases bp(MESH:"Endoplasmic Reticulum Stress") + p(HGNC:HSPB1) association p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:21722302 + pubmed:14963027 - a(MESH:"1-Methyl-4-phenylpyridinium") increases path(MESH:"Parkinson Disease") + p(HGNC:HSPB1) decreases act(p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) + + - pmid:21722302 + pubmed:14963027 - a(MESH:"1-Methyl-4-phenylpyridinium") directlyIncreases bp(MESH:"Endoplasmic Reticulum Stress") + p(HGNC:HSPB1) decreases complex(p(HGNC:HSPB1), p(HGNC:MAPT)) + + - pmid:25036637 + pubmed:14963027 - bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") association p(HGNC:LTN1) + p(HGNC:HSPB1) increases complex(p(CONSO:"paired helical filaments"), p(HGNC:HSPB1)) - pmid:21882945 + pubmed:14963027 - bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") association a(MESH:"Molecular Chaperones") + p(HGNC:HSPB1) negativeCorrelation bp(GO:"neuron apoptotic process") - pmid:27181519 + pubmed:29844403 - bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") association a(CHEBI:"all-trans-retinoic acid") + a(PUBCHEM:132157820) decreases p(HGNC:HDAC6) - pmid:21722302 + pubmed:29844403 - a(HBP:"Motor Neurons") association path(MESH:"Amyotrophic Lateral Sclerosis") + a(PUBCHEM:132157820) directlyDecreases act(p(HGNC:HDAC6)) - pmid:21722302 + pubmed:29844403 - bp(GO:"motor neuron apoptotic process") association bp(GO:"axonal transport") + a(PUBCHEM:132157820) increases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) - pmid:27181519 + pubmed:29844403 - bp(GO:"motor neuron apoptotic process") positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") + a(PUBCHEM:132157820) increases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) - pmid:27181519 + pubmed:29844403 - bp(GO:"motor neuron apoptotic process") positiveCorrelation bp(GO:"muscle atrophy") + a(PUBCHEM:132157820) causesNoChange p(MESH:Histones, pmod(go:0006473 ! "protein acetylation")) - pmid:21722302 + pubmed:29844403 - a(GO:"Bunina body") association path(MESH:"Amyotrophic Lateral Sclerosis") + a(PUBCHEM:132157820) decreases path(MESH:"Cytotoxicity, Immunologic") - pmid:14556719 + pubmed:29844403 - a(GO:"Bunina body") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) + a(PUBCHEM:132157820) decreases bp(GO:"cell death") - pmid:14556719 + pubmed:29844403 - a(GO:"Bunina body") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) + a(PUBCHEM:132157820) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) - pmid:21722302 + pubmed:29844403 - a(CHEBI:ubiquitin) association path(MESH:"Amyotrophic Lateral Sclerosis") + a(PUBCHEM:132157820) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) - pmid:21722302 + pubmed:29844403 - p(MESH:"Superoxide Dismutase-1", var("?")) association path(MESH:"Amyotrophic Lateral Sclerosis") + a(PUBCHEM:132157820) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) - pmid:21722302 + pubmed:29844403 - p(HGNCGENEFAMILY:"Protein disulfide isomerases") association path(MESH:"Amyotrophic Lateral Sclerosis") + a(PUBCHEM:132157820) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) - pmid:24563850 + pubmed:29844403 - p(HGNCGENEFAMILY:"Protein disulfide isomerases") decreases bp(GO:"protein oxidation") + a(PUBCHEM:132157820) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) - pmid:24563850 + pubmed:29844403 - p(HGNCGENEFAMILY:"Protein disulfide isomerases") decreases bp(HBP:misfolding) + a(PUBCHEM:132157820) decreases p(HGNC:MAPT, loc(CONSO:"Tau aggregates")) - pmid:24563850 + pubmed:29844403 - p(HGNCGENEFAMILY:"Protein disulfide isomerases") decreases a(MESH:"Protein Aggregates") + a(PUBCHEM:132157820) increases deg(p(HGNC:MAPT)) - pmid:21722302 + pubmed:29844403 - a(MESH:"Superoxide Dismutase-1") association bp(MESH:"Unfolded Protein Response") + a(PUBCHEM:132157820) increases p(HGNCGENEFAMILY:"Heat shock 90kDa proteins", pmod(go:0006473 ! "protein acetylation")) - pmid:21722302 + pubmed:29844403 - a(MESH:"Superoxide Dismutase-1") association path(MESH:"Amyotrophic Lateral Sclerosis") + a(PUBCHEM:132157820) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396), pmod(go:0016567 ! "protein ubiquitination")) - pmid:21722302 + pubmed:29844403 - p(MESH:"derlin-1 protein, mouse") increases p(MESH:"ASK1 protein, S cerevisiae") + a(PUBCHEM:132157820) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) - pmid:21722302 + pubmed:29844403 - p(HGNC:VAPB, var("?")) association path(MESH:"Amyotrophic Lateral Sclerosis") + a(PUBCHEM:132157820) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) - pmid:21722302 + pubmed:29844403 - p(HGNC:VAPB, var("?")) decreases bp(MESH:"Unfolded Protein Response") + a(PUBCHEM:132157820) causesNoChange p(HGNC:CDK5) - pmid:21722302 + pubmed:29844403 - p(HGNC:VAPB, var("?")) increases bp(HBP:"protein aggregation") + a(PUBCHEM:132157820) causesNoChange p(HGNC:CDK5R1) - - - pmid:21722302 + pubmed:29844403 - p(HGNC:VAPB) association bp(MESH:"Unfolded Protein Response") + a(PUBCHEM:132157820) increases p(FPLX:AKT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:21722302 + pubmed:29844403 - p(HGNC:VAPB) association p(HGNC:XBP1) + a(PUBCHEM:132157820) decreases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 216)) - pmid:21722302 + pubmed:29844403 - p(HGNC:VAPB) association p(HGNC:ERN1) + a(PUBCHEM:132157820) decreases act(p(HGNC:GSK3B)) - pmid:21722302 + pubmed:29844403 - p(HGNC:VAPB) association p(HGNC:ATF6) + a(PUBCHEM:132157820) increases bp(GO:memory) - - - pmid:21722302 + pubmed:29844403 - p(HGNC:VAPB, pmod(Ub), var("p.Pro56Ser")) causesNoChange p(HGNC:XBP1) + a(PUBCHEM:132157820) increases bp(GO:memory) - pmid:21722302 + pubmed:29844403 - p(HGNC:VAPB, pmod(Ub), var("p.Pro56Ser")) causesNoChange p(HGNC:ERN1) + a(PUBCHEM:132157820) decreases path(DOID:"Alzheimer's disease") - pmid:21722302 + pubmed:29844403 - p(HGNC:VAPB, pmod(Ub), var("p.Pro56Ser")) causesNoChange p(HGNC:ATF6) + a(PUBCHEM:132157820) increases tloc(a(PUBCHEM:132157820), fromLoc(MESH:Blood), toLoc(MESH:Brain)) - - - pmid:21722302 + pubmed:29844403 - complex(p(HGNC:ATF6), p(HGNC:VAPB)) decreases act(p(HGNC:ATF6)) + a(PUBCHEM:132157820) increases bp(GO:learning) - + + + pubmed:29844403 + + a(PUBCHEM:132157820) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + - pmid:21722302 + pubmed:29844403 - complex(p(HGNC:ATF6), p(HGNC:VAPB, pmod(Ub), var("p.Pro56Ser"))) decreases act(p(HGNC:ATF6)) + a(PUBCHEM:132157820) decreases a(CONSO:"Tau aggregates") - - - pmid:21722302 + pubmed:29844403 - p(MESH:"TARBP1 protein, human") association path(MESH:"Amyotrophic Lateral Sclerosis") + a(PUBCHEM:132157820) increases p(INTERPRO:"Heat shock protein Hsp90 family", pmod(go:0006473 ! "protein acetylation")) - pmid:21722302 + pubmed:29844403 - p(MESH:"TARBP1 protein, human") association path(MESH:"Frontotemporal Lobar Degeneration") + a(PUBCHEM:132157820) increases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) - - - pmid:21722302 + pubmed:30837838 - p(MESH:"TARBP1 protein, human", var("?")) biomarkerFor path(MESH:"Amyotrophic Lateral Sclerosis") + p(MESH:Histones) association path(MESH:"Chromatin Assembly and Disassembly") - pmid:21722302 + pubmed:29844403 - p(MESH:"TARBP1 protein, human", var("?")) biomarkerFor path(MESH:"Frontotemporal Lobar Degeneration") + path(HP:"Abnormal synaptic transmission") increases bp(GO:"neuron death") - pmid:21722302 + pubmed:29844403 - p(MESH:"TARBP1 protein, human", pmod(Ub)) biomarkerFor path(MESH:"Amyotrophic Lateral Sclerosis") + p(CONSO:APP695, var("?")) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:21722302 + pubmed:29844403 - p(MESH:"TARBP1 protein, human", pmod(Ub)) biomarkerFor path(MESH:"Frontotemporal Lobar Degeneration") + p(CONSO:APP695, var("?")) increases p(HGNC:MAPT, loc(GO:cytosol)) - pmid:21722302 + pubmed:29844403 - path(DOID:"variant Creutzfeldt-Jakob disease") isA path(DOID:"prion disease") + p(CONSO:APP695, var("?")) increases p(HGNC:MAPT, loc(CONSO:"Tau aggregates")) - pmid:21722302 + pubmed:29844403 - path(DOID:"variant Creutzfeldt-Jakob disease") isA path(DOID:"neurodegenerative disease") + p(CONSO:APP695, var("?")) increases complex(p(HGNC:HDAC6), p(HGNCGENEFAMILY:"Heat shock 90kDa proteins")) - pmid:21722302 + pubmed:29844403 - path(DOID:"variant Creutzfeldt-Jakob disease") increases path(MESH:"Spongiform Encephalopathy with Neuropsychiatric Features") + p(CONSO:APP695, var("?")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) - pmid:21722302 + pubmed:29844403 - path(DOID:"variant Creutzfeldt-Jakob disease") increases bp(HBP:"protein aggregation") + p(CONSO:APP695, var("?")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) - pmid:21722302 + pubmed:29844403 - p(HGNC:PRNP, frag("106_126")) increases bp(MESH:Apoptosis) + p(CONSO:APP695, var("?")) causesNoChange p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) - pmid:21722302 + pubmed:29844403 - bp(GO:"neuron development") association p(HGNC:PRNP) + p(CONSO:APP695, var("?")) causesNoChange p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) - pmid:16973293 + pubmed:29844403 - bp(GO:"neuron development") positiveCorrelation p(HBP:"MARK4 isoform 2 (688 aa)") + p(CONSO:"Tau oligomers") increases p(CONSO:"Tau fibrils") - pmid:25437566 + pubmed:25478017 - act(p(FPLX:HSP90)) association a(CHEBI:ATP) + p(CONSO:"Tau oligomers") increases path(MESH:Tauopathies) - - - pmid:25437566 - - p(FPLX:HSP90) decreases a(CHEBI:"amyloid-beta polypeptide 42") - + - pmid:25437566 + pubmed:26751493 - p(FPLX:HSP90) increases bp(GO:"protein folding") + p(CONSO:"Tau oligomers") association bp(GO:"clathrin-dependent endocytosis") - pmid:23746257 + pubmed:27299292 - act(p(FPLX:HSP90)) increases bp(GO:"protein folding") + path(DOID:neuropathy) negativeCorrelation p(HGNC:TFEB) - pmid:25784053 + pubmed:29844403 - p(FPLX:HSP90) regulates bp(GO:"protein folding") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396), pmod(go:0016567 ! "protein ubiquitination")) increases deg(p(HGNC:MAPT)) - pmid:27491084 + pubmed:29844403 - p(FPLX:HSP90) association bp(HBP:Proteostasis) + a(PUBCHEM:462382) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) - pmid:29311797 + pubmed:25546293 - p(FPLX:HSP90) association bp(HBP:Proteostasis) + a(PUBCHEM:462382) decreases p(FPLX:Proteasome) - pmid:23746257 + pubmed:25546293 - act(p(FPLX:HSP90)) association bp(GO:"'de novo' protein folding") + a(PUBCHEM:462382) increases p(HGNC:CTNNB1, pmod(go:0016567 ! "protein ubiquitination")) - pmid:23746257 + pubmed:25546293 - act(p(FPLX:HSP90)) association bp(GO:"protein refolding") + a(PUBCHEM:462382) increases p(HGNC:CTNNB1) - pmid:23746257 + pubmed:30935091 - p(FPLX:HSP90) association bp(GO:"cell cycle") + a(PUBCHEM:462382) increases p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0016567 ! "protein ubiquitination", Lys, 49)) - pmid:23746257 + pubmed:30935091 - p(FPLX:HSP90) association bp(GO:"steroid hormone mediated signaling pathway") + a(PUBCHEM:462382) increases p(HGNCGENEFAMILY:"Beta catenins") - pmid:23746257 + pubmed:29844403 - p(FPLX:HSP90) association bp(GO:"calcium-mediated signaling") + p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) association act(p(HGNC:GSK3B)) - pmid:23746257 + doi:"10.4172/2168-975X.1000126" - p(FPLX:HSP90) association bp(GO:"protein transport") + p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) decreases act(p(HGNC:GSK3B)) - pmid:23746257 + pubmed:25331948 - p(FPLX:HSP90) association bp(GO:"protein secretion") + p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) decreases act(p(HGNC:GSK3B)) - pmid:23746257 + pubmed:22419736 - p(FPLX:HSP90) association bp(GO:"immune response") + p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) decreases act(p(HGNC:GSK3B)) - pmid:23746257 + pubmed:24183963 - p(FPLX:HSP90) association bp(MESH:"Heat-Shock Response") + p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) decreases act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) - pmid:25784053 + pubmed:29121589 - p(FPLX:HSP90) isA a(MESH:"Molecular Chaperones") + p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) decreases act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) - pmid:25784053 + pubmed:29844403 - p(FPLX:HSP90) regulates bp(MESH:Proteolysis) + p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) directlyDecreases act(p(HGNC:GSK3B)) - pmid:25784053 + pubmed:29844403 - act(p(FPLX:HSP90)) decreases act(p(HGNC:HSF1)) + p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) - pmid:24563850 + pubmed:26979166 - p(FPLX:HSP90) decreases path(MESH:"Protein Aggregation, Pathological") + p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) decreases act(p(HGNC:PRKACA), ma(go:0016301 ! "kinase activity")) - pmid:29311797 + pubmed:29844403 - p(FPLX:HSP90) regulates path(MESH:"Protein Aggregation, Pathological") + p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Tyr, 216)) association act(p(HGNC:GSK3B)) - pmid:21882945 + pubmed:29844403 - act(p(FPLX:HSP90)) association a(CHEBI:celastrol) + p(FPLX:AKT, pmod(go:0006468 ! "protein phosphorylation")) increases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) - pmid:21882945 + pubmed:25514383 - p(FPLX:HSP90) increases bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") + p(FPLX:AKT, pmod(go:0006468 ! "protein phosphorylation")) decreases bp(GO:"apoptotic process") - pmid:21882945 + pubmed:30697142 - p(FPLX:HSP90) increases bp(GO:"proteasomal protein catabolic process") + p(FPLX:AKT, pmod(go:0006468 ! "protein phosphorylation")) increases bp(MESH:Neuroprotection) - pmid:21882945 + pubmed:30697142 - p(FPLX:HSP90) increases bp(GO:autophagy) + p(FPLX:AKT, pmod(go:0006468 ! "protein phosphorylation")) decreases p(HGNC:GSK3B) - pmid:21882945 + pubmed:30697142 - p(FPLX:HSP90) increases act(p(HGNC:STUB1)) + p(FPLX:AKT, pmod(go:0006468 ! "protein phosphorylation")) increases act(p(HGNC:CREBBP), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) - pmid:21882945 + pubmed:30985105 - p(FPLX:HSP90) increases bp(GO:"protein catabolic process") + p(FPLX:AKT, pmod(go:0006468 ! "protein phosphorylation")) decreases bp(GO:autophagy) - pmid:21882945 + pubmed:25546293 - p(FPLX:HSP90) increases complex(a(GO:microtubule), p(HGNC:MAPT)) + a(PUBCHEM:5311) decreases p(MESH:"Histone Deacetylases") - pmid:21882945 + pubmed:25546293 - p(FPLX:HSP90) increases p(HGNC:MAPT, pmod(Ph)) + a(PUBCHEM:5311) increases p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)) - pmid:21882945 + pubmed:30935091 - p(FPLX:HSP90) regulates p(HGNC:MAPT, pmod(Ph)) + a(PUBCHEM:5311) decreases p(HGNC:HDAC6) - pmid:19363271 + pubmed:30935091 - p(FPLX:HSP90) positiveCorrelation p(HGNC:MAPT, pmod(Ph)) + a(PUBCHEM:5311) increases p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006473 ! "protein acetylation", Lys, 49)) - pmid:21882945 + pubmed:30935091 - p(FPLX:HSP90) regulates act(p(HGNC:GSK3B)) + a(PUBCHEM:5311) causesNoChange p(HGNCGENEFAMILY:"Beta catenins") - pmid:21882945 + pubmed:25546293 - p(FPLX:HSP90) regulates p(HGNC:MAPT, var("?")) + p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)) increases complex(p(HGNC:CSNK1A1), p(HGNC:CTNNB1)) - pmid:29311797 + pubmed:25546293 - p(FPLX:HSP90) increases p(HGNC:MAPT, var("?")) + p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)) increases complex(p(HGNC:CSNK1A1), p(HGNC:CTNNB1)) - pmid:25374103 + pubmed:25546293 - p(FPLX:HSP90) increases deg(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) + p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)) increases complex(p(HGNC:CTNNB1), p(HGNC:GSK3B)) - pmid:29311797 + pubmed:25546293 - p(FPLX:HSP90) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)) increases act(p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)), ma(GO:"cadherin binding")) - pmid:25374103 + pubmed:25546293 - p(FPLX:HSP90) increases deg(p(HGNC:MAPT, pmod(HBP:misfolded))) + p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)) positiveCorrelation p(HGNC:CTNNB1, loc(GO:"plasma membrane")) - pmid:29311797 + pubmed:25546293 - p(FPLX:HSP90) regulates a(HBP:"Tau aggregates") + p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)) increases p(HGNC:CTNNB1, loc(GO:nucleus)) - pmid:29311797 + pubmed:25546293 - p(FPLX:HSP90) increases act(p(FPLX:Proteasome)) + p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)) increases p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 45)) + + - pmid:29311797 + pubmed:25546293 - p(FPLX:HSP90) association bp(GO:"chaperone-mediated autophagy") + p(HGNC:CTNNB1, loc(GO:"plasma membrane")) positiveCorrelation p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)) @@ -107473,1980 +108646,2018 @@

Statements

- - - pmid:29311797 - - act(p(FPLX:HSP90), ma(GO:"ATPase activity")) increases path(MESH:Tauopathies) - + - - - pmid:19363271 - - p(FPLX:HSP90) association p(HBP:"VQIVYK motif") - + - - - pmid:19363271 - - p(FPLX:HSP90) increases complex(p(FPLX:HSP90), p(HGNC:MAPT)) - + - pmid:19363271 + pubmed:18494933 - p(FPLX:HSP90) positiveCorrelation bp(GO:"neurofibrillary tangle assembly") + deg(p(HGNC:CTNNB1)) positiveCorrelation p(HGNC:DKK1) - pmid:20133804 + pubmed:25546293 - p(FPLX:HSP90) association p(HGNC:FKBP4, frag("270_386")) + a(CONSO:crebinostat) decreases p(HGNC:HDAC1) - pmid:21367866 + pubmed:25546293 - act(p(FPLX:HSP90)) positiveCorrelation p(HGNC:CDC37) + a(CONSO:crebinostat) decreases p(HGNC:HDAC2) - pmid:21367866 + pubmed:25546293 - act(p(FPLX:HSP90)) negativeCorrelation deg(p(HGNC:MAPT)) + a(CONSO:crebinostat) decreases p(HGNC:HDAC3) - pmid:25437566 + pubmed:25546293 - act(p(FPLX:HSPA)) association a(CHEBI:ATP) + a(CONSO:crebinostat) decreases p(HGNC:HDAC6) - pmid:27491084 + pubmed:30935091 - p(FPLX:HSPA) association bp(HBP:Proteostasis) + a(CONSO:crebinostat) decreases p(HGNC:HDAC6) - pmid:27491084 + pubmed:25546293 - p(FPLX:HSPA) decreases p(HBP:"huntingtin aggregates") + a(CONSO:crebinostat) increases p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)) - pmid:27491084 + pubmed:30935091 - p(FPLX:HSPA) decreases path(MESH:"Protein Aggregation, Pathological") + a(CONSO:crebinostat) increases p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006473 ! "protein acetylation", Lys, 49)) - pmid:24563850 + pubmed:30935091 - p(FPLX:HSPA) decreases path(MESH:"Protein Aggregation, Pathological") + a(CONSO:crebinostat) causesNoChange p(HGNCGENEFAMILY:"Beta catenins") - pmid:27491084 + pubmed:27209302 - p(FPLX:HSPA) increases bp(GO:"'de novo' protein folding") + p(HGNC:HDAC1) decreases p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation")) - pmid:23746257 + pubmed:30640040 - act(p(FPLX:HSPA)) association bp(GO:"'de novo' protein folding") + p(HGNC:HDAC1) association a(PUBCHEM:4261) - pmid:23746257 + pubmed:18305152 - act(p(FPLX:HSPA)) association bp(GO:"'de novo' protein folding") + p(HGNC:HDAC1) association act(p(HGNC:RB1)) - - - pmid:24563850 - - p(FPLX:HSPA) increases bp(GO:"'de novo' protein folding") - + - pmid:27491084 + pubmed:27209302 - p(FPLX:HSPA) decreases bp(HBP:misfolding) + p(HGNC:HDAC2) decreases p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation")) - pmid:24563850 + pubmed:30640040 - p(FPLX:HSPA) decreases bp(HBP:misfolding) + p(HGNC:HDAC3) association a(PUBCHEM:4261) - pmid:27491084 + pubmed:28771976 - p(FPLX:HSPA) decreases a(MESH:"Protein Aggregates") + p(HGNC:HDAC3) increases a(CHEBI:amyloid-beta) - pmid:27491084 + pubmed:28771976 - p(FPLX:HSPA) decreases a(MESH:"Protein Aggregates") + p(HGNC:HDAC3) increases bp(GO:"microglial cell activation") - pmid:27491084 + pubmed:28771976 - p(FPLX:HSPA) decreases path(HBP:proteotoxicity) + p(HGNC:HDAC3) decreases a(GO:"dendritic spine") - pmid:27491084 + pubmed:25546293 - p(FPLX:HSPA) decreases path(HBP:proteotoxicity) + a(PUBCHEM:10487) decreases p(HGNC:HDAC1) - pmid:27491084 + pubmed:25546293 - p(FPLX:HSPA) decreases a(HBP:"alpha-synuclein aggregates") + a(PUBCHEM:10487) decreases p(HGNC:HDAC2) - pmid:23746257 + pubmed:25546293 - p(FPLX:HSPA) decreases a(HBP:"alpha-synuclein aggregates") + a(PUBCHEM:10487) decreases p(HGNC:HDAC3) - pmid:14556719 + pubmed:25546293 - p(FPLX:HSPA) increases complex(p(HGNC:ATXN3, frag("?")), p(HGNC:PRKN)) + a(PUBCHEM:10487) causesNoChange p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)) - pmid:14556719 + pubmed:25546293 - p(FPLX:HSPA) decreases a(HBP:"protein aggregates") + a(PUBCHEM:16773791) decreases p(HGNC:HDAC3) - pmid:14556719 + pubmed:25546293 - p(FPLX:HSPA) decreases bp(GO:"cell death") + a(PUBCHEM:16773791) causesNoChange p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)) - pmid:23746257 + pubmed:30935091 - act(p(FPLX:HSPA)) association bp(GO:"protein refolding") + a(PUBCHEM:16773791) decreases p(HGNCGENEFAMILY:"Histone deacetylases, class I") - pmid:23746257 + pubmed:30935091 - act(p(FPLX:HSPA)) association bp(GO:"protein refolding") + a(PUBCHEM:16773791) causesNoChange p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006473 ! "protein acetylation", Lys, 49)) - pmid:23746257 + pubmed:25546293 - act(p(FPLX:HSPA)) association bp(GO:"intracellular protein transmembrane transport") + a(PUBCHEM:6675804) decreases p(HGNC:HDAC6) - pmid:23746257 + pubmed:25546293 - act(p(FPLX:HSPA)) association bp(GO:"protein catabolic process") + a(PUBCHEM:6675804) increases p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)) - pmid:23746257 + pubmed:25546293 - p(FPLX:HSPA) decreases a(HBP:"huntingtin aggregates") + a(PUBCHEM:49850262) decreases p(HGNC:HDAC6) - pmid:25784053 + pubmed:30935091 - p(FPLX:HSPA) isA a(MESH:"Molecular Chaperones") + a(PUBCHEM:49850262) decreases p(HGNC:HDAC6) - pmid:25784053 + pubmed:30935091 - p(FPLX:HSPA) regulates bp(GO:"protein folding") + a(PUBCHEM:49850262) decreases p(HGNC:HDAC6) - pmid:24563850 + pubmed:24844691 - p(FPLX:HSPA) increases bp(GO:"protein folding") + a(PUBCHEM:49850262) directlyDecreases act(p(HGNC:HDAC6)) - pmid:25784053 + pubmed:25546293 - p(FPLX:HSPA) regulates bp(MESH:Proteolysis) + a(PUBCHEM:49850262) increases p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)) - pmid:25784053 + pubmed:30935091 - p(FPLX:HSPA) positiveCorrelation path(MESH:"Huntington Disease") + a(PUBCHEM:49850262) increases bp(GO:"learning or memory") - pmid:29626319 + pubmed:30935091 - p(FPLX:HSPA) increases deg(a(CHEBI:"amyloid-beta")) + a(PUBCHEM:49850262) decreases p(HGNC:MAPT) - pmid:25437566 + pubmed:30935091 - act(p(HGNC:HSPD1)) association a(CHEBI:ATP) + a(PUBCHEM:49850262) decreases act(p(HGNC:MAPT), ma(GO:"microtubule binding")) - pmid:27491084 + pubmed:30935091 - p(HGNC:HSPD1) association bp(HBP:Proteostasis) + a(PUBCHEM:49850262) association p(MESH:"Amyloidogenic Proteins") - pmid:25784053 + pubmed:30935091 - p(HGNC:HSPD1) increases bp(HBP:Proteostasis) + a(PUBCHEM:49850262) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:23746257 + pubmed:30935091 - p(HGNC:HSPD1) decreases a(MESH:"Protein Aggregates") + a(PUBCHEM:49850262) increases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) - pmid:25784053 + pubmed:30935091 - p(HGNC:HSPD1) isA a(MESH:"Molecular Chaperones") + a(PUBCHEM:49850262) increases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) - pmid:25784053 + pubmed:30935091 - p(HGNC:HSPD1) association bp(MESH:"Energy Metabolism") + a(PUBCHEM:49850262) positiveCorrelation bp(GO:"axonal transport") - pmid:27491084 + pubmed:30935091 - p(HGNC:TPR) association bp(HBP:Proteostasis) + a(PUBCHEM:49850262) positiveCorrelation bp(GO:"axonal transport") - pmid:27491084 + pubmed:30935091 - p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") association bp(HBP:Proteostasis) + a(PUBCHEM:49850262) increases bp(GO:"motor behavior") - pmid:27491084 + pubmed:30935091 - p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") increases act(p(FPLX:HSPA), ma(GO:"ATPase activity")) + a(PUBCHEM:49850262) decreases p(HGNC:MAPT, pmod(CONSO:"protein aggregates"), pmod(go:0006473 ! "protein acetylation")) - pmid:23746257 + pubmed:30935091 - p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") regulates act(p(FPLX:HSPA)) + a(PUBCHEM:49850262) decreases p(HGNC:HDAC6, pmod(CONSO:"protein aggregates")) - pmid:23746257 + pubmed:30935091 - p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") decreases a(HBP:"huntingtin aggregates") + a(PUBCHEM:49850262) increases p(HGNC:HSPB1) - pmid:23746257 + pubmed:30935091 - p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") decreases a(HBP:"alpha-synuclein aggregates") + a(PUBCHEM:49850262) increases p(HGNCGENEFAMILY:"Heat shock 70kDa proteins") - pmid:25784053 + pubmed:24844691 - p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") isA a(MESH:"Molecular Chaperones") + a(PUBCHEM:49850262) increases bp(GO:behavior) - pmid:27491084 + pubmed:24844691 - p(FPLX:HSPB) association bp(HBP:Proteostasis) + a(PUBCHEM:49850262) decreases a(CHEBI:amyloid-beta) - pmid:27491084 + pubmed:24844691 - p(FPLX:HSPB) association bp(HBP:misfolding) + a(PUBCHEM:49850262) decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:23746257 + pubmed:24844691 - act(p(FPLX:HSPB)) decreases a(MESH:"Protein Aggregates") + a(PUBCHEM:49850262) increases p(FPLX:Tubulin, pmod(go:0006473 ! "protein acetylation")) - pmid:25784053 + pubmed:24844691 - p(FPLX:HSPB) isA a(MESH:"Molecular Chaperones") + a(PUBCHEM:49850262) increases bp(GO:autophagy) - pmid:25437566 + pubmed:25546293 - p(HGNC:HSPA8) decreases a(CHEBI:"amyloid-beta polypeptide 42") + a(PUBCHEM:53340666) decreases p(HGNC:HDAC6) - pmid:25437566 + pubmed:30935091 - p(HGNC:HSPA8) increases bp(GO:"protein folding") + a(PUBCHEM:53340666) decreases p(HGNC:HDAC6) - pmid:25437566 + pubmed:30935091 - p(HGNC:HSPA8) increases a(HBP:"huntingtin aggregates") + a(PUBCHEM:53340666) decreases p(HGNC:HDAC6) - pmid:29758300 + pubmed:30935091 - p(HGNC:HSPA8) increases deg(p(HGNC:MAPT)) + a(PUBCHEM:53340666) decreases p(HGNC:HDAC6) - pmid:21882945 + pubmed:30640040 - act(p(HGNC:HSPA8)) increases deg(p(HGNC:MAPT)) + a(PUBCHEM:53340666) association p(HGNC:HDAC6) - pmid:18930136 + pubmed:24844691 - p(HGNC:HSPA8) association bp(GO:"chaperone-mediated autophagy") + a(PUBCHEM:53340666) directlyDecreases act(p(HGNC:HDAC6)) - pmid:18930136 + pubmed:25546293 - p(HGNC:HSPA8) increases complex(a(MESH:Proteins), p(HGNC:HSPA8)) + a(PUBCHEM:53340666) increases p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)) - pmid:24706768 + pubmed:25546293 - p(HGNC:HSPA8) increases bp(GO:"clathrin-dependent endocytosis") + a(PUBCHEM:53340666) increases p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49), loc(GO:"plasma membrane")) - pmid:24706768 + pubmed:25546293 - p(HGNC:HSPA8) increases bp(GO:"clathrin-dependent endocytosis") + a(PUBCHEM:53340666) increases p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49), loc(GO:cytoplasm)) - pmid:24706768 + pubmed:25546293 - p(HGNC:HSPA8) increases bp(GO:"clathrin coat disassembly") + a(PUBCHEM:53340666) decreases p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49), loc(GO:nucleus)) - pmid:21882945 + pubmed:25546293 - p(HGNC:HSPA8) regulates complex(a(GO:microtubule), p(HGNC:MAPT)) + a(PUBCHEM:53340666) increases p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)) - pmid:18500754 + pubmed:25546293 - p(HGNC:HSPA8) association p(HBP:"microtubule-binding region") + a(PUBCHEM:53340666) causesNoChange p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 33)) - pmid:18500754 + pubmed:25546293 - act(p(HGNC:HSPA8)) negativeCorrelation act(complex(GO:microtubule)) + a(PUBCHEM:53340666) causesNoChange p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 37)) - pmid:25437566 + pubmed:25546293 - p(FPLX:"CCT_complex") decreases a(CHEBI:"amyloid-beta polypeptide 42") + a(PUBCHEM:53340666) causesNoChange p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Thr, 41)) - pmid:25437566 + pubmed:25546293 - p(FPLX:"CCT_complex") increases a(HBP:"huntingtin aggregates") + a(PUBCHEM:53340666) causesNoChange p(HGNC:CTNNB1, pmod(go:0016567 ! "protein ubiquitination")) - pmid:23746257 + pubmed:25546293 - p(FPLX:"CCT_complex") decreases a(HBP:"huntingtin aggregates") + a(PUBCHEM:53340666) increases p(HGNC:CTNNB1, loc(GO:"plasma membrane")) - pmid:25784053 + pubmed:25546293 - p(FPLX:"CCT_complex") association a(MESH:"Cellular Structures") + a(PUBCHEM:53340666) causesNoChange act(p(HGNC:CTNNB1), ma(GO:"cadherin binding")) - pmid:25784053 + pubmed:30935091 - p(FPLX:"CCT_complex") association bp(GO:"cell division") + a(PUBCHEM:53340666) association p(MESH:"Amyloidogenic Proteins") - pmid:25784053 + pubmed:30935091 - p(FPLX:"CCT_complex") association bp(GO:"intracellular transport") + a(PUBCHEM:53340666) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:25784053 + pubmed:30935091 - p(FPLX:"CCT_complex") decreases act(p(HGNC:HSF1)) + a(PUBCHEM:53340666) increases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) - pmid:25437566 + pubmed:30935091 - p(HGNC:DNAJA1) decreases a(CHEBI:"amyloid-beta polypeptide 42") + a(PUBCHEM:53340666) increases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) - pmid:25437566 + pubmed:30935091 - p(HGNC:DNAJA1) increases bp(GO:"protein folding") + a(PUBCHEM:53340666) increases p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006473 ! "protein acetylation", Lys, 49)) - pmid:25437566 + pubmed:30935091 - p(HGNC:DNAJA1) increases a(HBP:"huntingtin aggregates") + a(PUBCHEM:53340666) increases p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006473 ! "protein acetylation", Lys, 49), loc(GO:"plasma membrane")) - pmid:25437566 + pubmed:30935091 - p(HGNC:STIP1) decreases a(CHEBI:"amyloid-beta polypeptide 42") + a(PUBCHEM:53340666) increases p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006473 ! "protein acetylation", Lys, 49), loc(GO:cytoplasm)) - pmid:23746257 + pubmed:30935091 - p(HGNC:STIP1) decreases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) + a(PUBCHEM:53340666) increases complex(p(HGNC:CDH2), p(HGNCGENEFAMILY:"Beta catenins"), loc(GO:"plasma membrane")) - pmid:25036637 + pubmed:30935091 - p(HGNC:STIP1) increases complex(p(HGNC:STIP1), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) + a(PUBCHEM:53340666) increases p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006473 ! "protein acetylation")) - pmid:29311797 + pubmed:30270813 - p(HGNC:STIP1) decreases p(HGNC:MAPT) + a(PUBCHEM:53340666) decreases path(EFO:"peripheral neuropathy") - pmid:29311797 + pubmed:30270813 - p(HGNC:STIP1) association bp(GO:"chaperone-mediated autophagy") + a(PUBCHEM:53340666) causesNoChange bp(GO:cognition) - pmid:25437566 + pubmed:30640040 - p(HGNC:TTC1) increases bp(GO:"protein folding") + a(PUBCHEM:53340666) increases a(CONSO:"Tau aggregates") - pmid:25437566 + pubmed:24844691 - p(HGNC:CCT5) causesNoChange a(HBP:"huntingtin aggregates") + a(PUBCHEM:53340666) increases bp(GO:behavior) - pmid:25437566 + pubmed:24844691 - p(HGNC:DNAJA4) increases a(HBP:"huntingtin aggregates") + a(PUBCHEM:53340666) decreases a(CHEBI:amyloid-beta) - pmid:25437566 + pubmed:24844691 - p(HGNC:HSPA14) increases a(HBP:"huntingtin aggregates") + a(PUBCHEM:53340666) decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:25437566 + pubmed:24844691 - p(HGNC:CDC23) increases a(HBP:"huntingtin aggregates") + a(PUBCHEM:53340666) increases p(FPLX:Tubulin, pmod(go:0006473 ! "protein acetylation")) - pmid:25437566 + pubmed:24844691 - p(HGNC:CDC27) increases a(HBP:"huntingtin aggregates") + a(PUBCHEM:53340666) increases bp(GO:autophagy) - pmid:25036637 + pubmed:25546293 - p(HGNC:HSP90AB1) directlyIncreases complex(a(MESH:"Protein Kinases"), p(HGNC:HSP90AB1)) + p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 45)) decreases act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) - pmid:29311797 + pubmed:25546293 - p(HGNC:HSP90AB1) association bp(GO:"embryo development") + p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 45)) causesNoChange p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 33)) - pmid:29311797 + pubmed:25546293 - p(HGNC:HSP90AB1) association bp(GO:"cell maturation") + p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 45)) causesNoChange p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 37)) - pmid:29311797 + pubmed:25546293 - p(HGNC:HSP90AB1) association bp(GO:"cytoskeleton organization") + p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 45)) causesNoChange p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Thr, 41)) - pmid:29311797 + pubmed:25546293 - p(HGNC:HSP90AB1) association bp(GO:"signal transduction") + p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 33)) increases complex(p(HGNC:BTRC), p(HGNC:CTNNB1)) - pmid:29311797 + pubmed:25546293 - p(HGNC:HSP90AB1) association bp(GO:"adaptation of signaling pathway") + p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 33)) increases deg(p(HGNC:CTNNB1)) - pmid:27491084 + pubmed:25546293 - bp(HBP:Proteostasis) association p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") + p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 37)) increases complex(p(HGNC:BTRC), p(HGNC:CTNNB1)) - pmid:27491084 + pubmed:25546293 - bp(HBP:Proteostasis) association p(HGNC:HSPD1) + p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 37)) increases deg(p(HGNC:CTNNB1)) - pmid:27491084 + pubmed:25546293 - bp(HBP:Proteostasis) association p(FPLX:HSPA) + p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Thr, 41)) increases complex(p(HGNC:BTRC), p(HGNC:CTNNB1)) - pmid:27491084 + pubmed:25546293 - bp(HBP:Proteostasis) association p(HGNC:TPR) + p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Thr, 41)) increases deg(p(HGNC:CTNNB1)) - pmid:27491084 + pubmed:25546293 - bp(HBP:Proteostasis) association p(FPLX:HSPB) + complex(p(HGNC:CSNK1A1), p(HGNC:CTNNB1)) increases act(p(HGNC:CSNK1A1), ma(go:0016301 ! "kinase activity")) + + - pmid:27491084 + pubmed:25546293 - bp(HBP:Proteostasis) association p(FPLX:HSP90) + act(p(HGNC:CSNK1A1), ma(go:0016301 ! "kinase activity")) increases p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 45)) - pmid:29311797 + pubmed:30935091 - bp(HBP:Proteostasis) association p(FPLX:HSP90) + p(HGNC:CSNK1A1) increases p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006468 ! "protein phosphorylation", Ser, 45)) - pmid:27491084 + pubmed:30444369 - bp(HBP:Proteostasis) association p(HGNCGENEFAMILY:"AAA ATPases") + p(HGNC:CSNK1A1) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:23746257 + pubmed:30444369 - bp(HBP:Proteostasis) association bp(GO:"inflammatory response") + p(HGNC:CSNK1A1) regulates act(p(FPLX:"Gamma_secretase")) - pmid:23746257 + pubmed:30444369 - bp(HBP:Proteostasis) association bp(GO:"response to oxidative stress") + p(HGNC:CSNK1A1) increases bp(GO:"amyloid-beta formation") - pmid:23746257 + pubmed:25974414 - bp(HBP:Proteostasis) association bp(GO:"behavioral response to starvation") + act(p(HGNC:CSNK1A1), ma(go:0016301 ! "kinase activity")) directlyIncreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:23746257 + pubmed:25673844 - bp(HBP:Proteostasis) negativeCorrelation bp(GO:"cell death") + p(HGNC:CSNK1A1) isA p(FPLX:CSNK1) - pmid:25784053 + pubmed:30837838 - bp(HBP:Proteostasis) association bp(MESH:"Protein Biosynthesis") + p(HGNC:CSNK1A1) increases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation", Ser, 379)) - pmid:25784053 + pubmed:30837838 - bp(HBP:Proteostasis) association bp(GO:"protein folding") + p(HGNC:CSNK1A1) increases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation", Ser, 403)) - pmid:25784053 + pubmed:30837838 - bp(HBP:Proteostasis) association path(MESH:"Protein Aggregation, Pathological") + p(HGNC:CSNK1A1) increases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) - pmid:25784053 + pubmed:30837838 - bp(HBP:Proteostasis) association bp(MESH:Proteolysis) + p(HGNC:CSNK1A1) increases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation", Ser, 409)) - pmid:25784053 + pubmed:30837838 - bp(HBP:Proteostasis) decreases bp(MESH:Aging) + p(HGNC:CSNK1A1) increases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation", Ser, 410)) - pmid:21882945 + pubmed:25546293 - bp(HBP:Proteostasis) regulates p(HGNC:MAPT) + p(HGNC:CTNNB1, pmod(go:0016567 ! "protein ubiquitination", Lys, 49)) increases act(p(FPLX:Proteasome)) - pmid:21882945 + pubmed:25546293 - bp(HBP:Proteostasis) regulates a(MESH:Proteins) + act(p(FPLX:Proteasome)) increases deg(p(HGNC:CTNNB1)) - pmid:27181519 + pubmed:23746257 - bp(HBP:Proteostasis) negativeCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") + p(FPLX:Proteasome) increases bp(GO:"protein catabolic process") - pmid:27491084 + pubmed:26195256 - p(HGNCGENEFAMILY:"AAA ATPases") association bp(HBP:Proteostasis) + act(p(FPLX:Proteasome)) increases bp(GO:"protein catabolic process") - pmid:27491084 + pubmed:23746257 - p(HGNC:HSPA1L) decreases path(HP:Neurodegeneration) + p(FPLX:Proteasome) increases bp(GO:"protein unfolding") - pmid:27491084 + pubmed:25784053 - p(HGNC:HSPA1L) decreases path(HP:Neurodegeneration) + p(FPLX:Proteasome) increases bp(MESH:Proteolysis) - pmid:27491084 + pubmed:25784053 - p(HGNC:ATXN3, var("?")) association path(HP:Neurodegeneration) + p(FPLX:Proteasome) decreases path(MESH:"Protein Aggregation, Pathological") - pmid:23528736 + pubmed:25784053 - p(HGNC:ATXN3, var("?")) association path(MESH:"Neurodegenerative Diseases") + act(p(FPLX:Proteasome)) negativeCorrelation path(MESH:"Alzheimer Disease") - - - - - pmid:14556719 + pubmed:30145931 - p(HGNC:ATXN3) increases complex(p(HGNC:ATXN3), p(HGNC:RAD23A)) + act(p(FPLX:Proteasome)) decreases path(CONSO:neurotoxicity) - - - pmid:27491084 + pubmed:30145931 - p(HGNC:AR, var("?")) association path(HP:Neurodegeneration) + act(p(FPLX:Proteasome)) decreases p(HGNC:MAPT) - - - pmid:30640040 + pubmed:30145931 - p(HGNC:AR) association a(PUBCHEM:5833) + act(p(FPLX:Proteasome)) increases deg(p(HGNC:MAPT, loc(MESH:Dendrites))) - pmid:25784053 + pubmed:26195256 - path(MESH:"Protein Aggregation, Pathological") association bp(HBP:Proteostasis) + act(p(FPLX:Proteasome)) increases deg(p(HGNC:MAPT)) - pmid:25784053 + pubmed:30145931 - path(MESH:"Protein Aggregation, Pathological") association path(MESH:"Neurodegenerative Diseases") + act(p(FPLX:Proteasome)) increases deg(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262), pmod(go:0006468 ! "protein phosphorylation", Ser, 356))) - pmid:25784053 + pubmed:29311797 - path(MESH:"Protein Aggregation, Pathological") negativeCorrelation p(HGNC:HSPA1A) + act(p(FPLX:Proteasome)) negativeCorrelation path(MESH:"Neurodegenerative Diseases") - pmid:25784053 + pubmed:26195256 - path(MESH:"Protein Aggregation, Pathological") negativeCorrelation p(HGNC:HSPA1B) + act(p(FPLX:Proteasome)) increases deg(a(CHEBI:amyloid-beta, loc(GO:intracellular))) - pmid:25784053 + pubmed:22941973 - path(MESH:"Protein Aggregation, Pathological") negativeCorrelation p(HGNC:DNAJB1) + act(p(FPLX:Proteasome)) increases deg(p(RGD:Syp)) - pmid:24706768 + pubmed:24964035 - path(MESH:"Protein Aggregation, Pathological") decreases act(p(HGNC:HSPA8)) + act(p(FPLX:Proteasome)) increases deg(p(HGNC:SMAD2)) - pmid:24706768 + pubmed:25546293 - path(MESH:"Protein Aggregation, Pathological") decreases bp(GO:"clathrin-dependent endocytosis") + p(HGNC:CTNNB1, pmod(go:0016567 ! "protein ubiquitination")) increases deg(p(HGNC:CTNNB1)) - pmid:27574109 + pubmed:25546293 - path(MESH:"Protein Aggregation, Pathological") positiveCorrelation a(HBP:"3R tau") + bp(GO:"epidermal growth factor receptor signaling pathway") decreases p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)) - pmid:27574109 + pubmed:25546293 - path(MESH:"Protein Aggregation, Pathological") positiveCorrelation a(HBP:"3R tau") + bp(GO:"epidermal growth factor receptor signaling pathway") increases p(HGNC:CTNNB1, loc(GO:nucleus)) - pmid:27574109 + pubmed:25546293 - path(MESH:"Protein Aggregation, Pathological") positiveCorrelation a(HBP:"4R tau") + act(p(HGNC:KAT2B)) increases p(HGNC:CTNNB1, pmod(go:0006473 ! "protein acetylation", Lys, 49)) - pmid:27574109 + pubmed:25546293 - path(MESH:"Protein Aggregation, Pathological") positiveCorrelation a(HBP:"4R tau") + act(p(HGNC:KAT2B)) increases p(HGNC:CTNNB1, loc(GO:nucleus)) - pmid:27574109 + pubmed:25672970 - path(MESH:"Protein Aggregation, Pathological") positiveCorrelation a(HBP:"Tau isoform F (441 aa)") + act(p(HGNC:KAT2B)) increases p(FPLX:NFkappaB, pmod(go:0006473 ! "protein acetylation", Lys, 122)) - pmid:27491084 + pubmed:24686445 - p(HGNC:STUB1) decreases path(HP:Neurodegeneration) + act(p(HGNC:KAT2B)) increases p(CONSO:"Histone H3", pmod(go:0006473 ! "protein acetylation", Lys, 9)) - pmid:22908190 + pubmed:25546293 - p(HGNC:STUB1) increases complex(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)), p(HGNC:STUB1)) + complex(p(HGNC:BTRC), p(HGNC:CTNNB1)) increases act(p(HGNC:BTRC), ma(GO:"ubiquitin protein ligase activity")) - pmid:25036637 + pubmed:25546293 - p(HGNC:STUB1) increases complex(p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) + p(HGNC:HDAC6, pmod(go:0006473 ! "protein acetylation", Lys, 49)) decreases p(HGNC:CTNNB1, pmod(go:0016567 ! "protein ubiquitination")) - pmid:25036637 + pubmed:25546293 - p(HGNC:STUB1) directlyIncreases complex(p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) + p(HGNC:HDAC6, pmod(go:0006473 ! "protein acetylation", Ser, 45)) decreases p(HGNC:CTNNB1, pmod(go:0016567 ! "protein ubiquitination")) - pmid:25036637 + pubmed:30935091 - p(HGNC:STUB1) directlyIncreases complex(p(FPLX:HSP90), p(HGNC:STUB1)) + p(HGNC:SOD1, var("p.Gly93Ala")) decreases p(HGNC:HDAC6) - pmid:25036637 + pubmed:30515821 - p(HGNC:STUB1) regulates bp(GO:"cellular protein catabolic process") + p(HGNC:SOD1, var("p.Gly93Ala")) increases path(DOID:"muscular atrophy") - pmid:24027553 + pubmed:26996954 - p(HGNC:STUB1) increases p(HGNC:MAPT, pmod(UbK48)) + path(MESH:"Amyloid Neuropathies") association g(DBSNP:rs3824968) - pmid:26631930 + pubmed:30935091 - p(HGNC:STUB1) increases p(HGNC:MAPT, pmod(UbK48)) + p(MESH:"Amyloidogenic Proteins") association a(PUBCHEM:53340666) - pmid:24027553 + pubmed:30935091 - p(HGNC:STUB1) increases p(HGNC:MAPT, pmod(UbK63)) + p(MESH:"Amyloidogenic Proteins") association a(PUBCHEM:49850262) - pmid:23528736 + pubmed:30935091 - p(HGNC:STUB1) association path(MESH:"Neurodegenerative Diseases") + p(HGNC:AKT2) increases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) - pmid:23528736 + pubmed:30935091 - p(HGNC:STUB1) association path(MESH:"Alzheimer Disease") + a(PUBCHEM:57382288) positiveCorrelation bp(GO:"axonal transport") - pmid:29311797 + pubmed:30935091 - p(HGNC:STUB1) association path(MESH:"Alzheimer Disease") + path(DOID:"Charcot-Marie-Tooth disease") negativeCorrelation bp(GO:"axonal transport") - pmid:21882945 + pubmed:30935091 - act(p(HGNC:STUB1)) increases bp(GO:"protein catabolic process") + path(DOID:"Charcot-Marie-Tooth disease") increases p(HGNC:GARS, var("?")) - pmid:21882945 + pubmed:30935091 - act(p(HGNC:STUB1)) increases bp(GO:"protein ubiquitination") + p(HGNC:GARS, var("?")) negativeCorrelation bp(GO:"axonal transport") - pmid:25374103 + pubmed:30935091 - p(HGNC:STUB1) increases deg(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) + p(HGNC:GARS, var("?")) decreases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) + + - pmid:25374103 + pubmed:30935091 - p(HGNC:STUB1) regulates act(p(HGNC:CASP3)) + path(DOID:"Rett syndrome") increases p(HGNC:HDAC6) - pmid:25374103 + pubmed:30935091 - p(HGNC:STUB1) increases deg(p(HBP:"Tau C3")) + path(DOID:"Rett syndrome") decreases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) - pmid:25374103 + pubmed:26979166 - p(HGNC:STUB1) decreases p(HBP:"Tau C3") + path(DOID:"Rett syndrome") isA path(HP:Autism) - pmid:25374103 + pubmed:30935091 - p(HGNC:STUB1) increases deg(p(HBP:"Tau C3")) + p(HGNC:MECP2, var("?")) negativeCorrelation bp(GO:"synaptic transmission, GABAergic") - pmid:25374103 + pubmed:30935091 - p(HGNC:STUB1) causesNoChange bp(GO:"cell death") + p(HGNC:MECP2, var("?")) increases p(HGNC:HDAC6) - pmid:25374103 + pubmed:30935091 - p(HGNC:STUB1) increases complex(p(HGNC:HSPA8), p(HGNC:MAPT, pmod(Ub)), p(HGNC:STUB1)) + p(HGNC:MECP2, var("?")) decreases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) + + - pmid:25374103 + pubmed:30935091 - p(HGNC:STUB1) increases deg(p(HBP:"4R tau", var("p.Lys280del"))) + bp(GO:"synaptic transmission, GABAergic") negativeCorrelation p(HGNC:MECP2, var("?")) - pmid:25374103 + pubmed:29428175 - p(HGNC:STUB1) decreases act(p(FPLX:Caspase)) + bp(GO:"synaptic transmission, GABAergic") association p(MESH:"Receptors, Glutamate", loc(GO:"postsynaptic membrane")) - pmid:25374103 + pubmed:30935091 - p(HGNC:STUB1) increases deg(p(FPLX:Caspase)) + a(CHEBI:"valproic acid") decreases p(MESH:"Histone Deacetylases") - pmid:29311797 + pubmed:30935091 - p(HGNC:STUB1) association path(MESH:"Huntington Disease") + a(CHEBI:"sodium butyrate") decreases p(HGNC:HDAC6) - pmid:29311797 + pubmed:30935091 - p(HGNC:STUB1) association path(MESH:"Parkinson Disease") + a(PUBCHEM:4261) decreases p(HGNC:HDAC6) - pmid:29311797 + pubmed:30935091 - p(HGNC:STUB1) association path(MESH:"Cystic Fibrosis") + a(PUBCHEM:4261) decreases p(HGNCGENEFAMILY:"Histone deacetylases, class I") - pmid:29311797 + pubmed:30935091 - p(HGNC:STUB1) association path(MESH:Neoplasms) + a(PUBCHEM:4261) decreases p(HGNCGENEFAMILY:"Histone deacetylases, class I") - pmid:14612456 + pubmed:30935091 - p(HGNC:STUB1) isA complex(p(HGNC:MAPT, pmod(Ph)), p(HGNC:STUB1), p(HGNC:UBE2D2)) + a(PUBCHEM:4261) decreases path(DOID:"antisocial personality disorder") - pmid:17954934 + pubmed:30935091 - p(HGNC:STUB1) isA complex(p(HGNC:BAG1), p(HGNC:MAPT), p(HGNC:STUB1)) + a(PUBCHEM:4261) causesNoChange p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006473 ! "protein acetylation", Lys, 49)) - pmid:27325702 + pubmed:30640040 - p(HGNC:STUB1) association p(HBP:"APP, ACR") + a(PUBCHEM:4261) increases a(CONSO:"Tau aggregates") - pmid:27325702 + pubmed:30640040 - p(HGNC:STUB1) isA complex(GO:"ubiquitin ligase complex") + a(PUBCHEM:4261) association p(HGNC:HDAC1) - pmid:27491084 + pubmed:30640040 - p(UNIPROT:P15705) decreases path(HBP:proteotoxicity) + a(PUBCHEM:4261) association p(HGNC:HDAC3) - pmid:27491084 + pubmed:30935091 - p(UNIPROT:P32589) regulates act(p(FPLX:HSPA)) + a(PUBCHEM:134164107) decreases p(HGNC:HDAC6) - pmid:27491084 + pubmed:30935091 - p(UNIPROT:P32589) decreases path(HBP:proteotoxicity) + a(PUBCHEM:134164107) regulates path(MESH:Affect) - pmid:27491084 + pubmed:30935091 - p(UNIPROT:P32589) decreases path(MESH:"Protein Aggregation, Pathological") + a(PUBCHEM:134164107) regulates bp(GO:"gene expression") - pmid:27491084 + pubmed:30935091 - p(HGNC:HSPB7) decreases path(HBP:proteotoxicity) + a(CHEBI:fluoxetine) decreases path(DOID:"antisocial personality disorder") - pmid:27491084 + pubmed:30935091 - p(HGNC:HSPB7) decreases a(MESH:"Protein Aggregates") + a(CHEBI:fluoxetine) increases p(HGNCGENEFAMILY:"Beta catenins", loc(GO:"plasma membrane")) - pmid:27491084 + pubmed:30935091 - p(UNIPROT:Q9XXG5) decreases path(HBP:proteotoxicity) + a(CHEBI:fluoxetine) causesNoChange p(HGNCGENEFAMILY:"Beta catenins", loc(GO:nucleus)) - pmid:27491084 + pubmed:30935091 - p(UNIPROT:Q9XXG5) decreases a(MESH:"Protein Aggregates") + a(CHEBI:fluoxetine) increases p(HGNC:CDH2) - pmid:27491084 + pubmed:19721446 - p(UNIPROT:P12612) decreases path(HBP:proteotoxicity) + a(CHEBI:fluoxetine) decreases a(CHEBI:monoamine) - pmid:27491084 + pubmed:19721446 - p(UNIPROT:P12612) decreases a(MESH:"Protein Aggregates") + a(CHEBI:fluoxetine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:27491084 + pubmed:30027901 - p(UNIPROT:P02829) decreases path(HBP:proteotoxicity) + a(CHEBI:fluoxetine) isA a(MESH:"Antidepressive Agents") - pmid:27491084 + pubmed:30027901 - p(UNIPROT:P02829) decreases a(MESH:"Protein Aggregates") + a(CHEBI:fluoxetine) decreases path(MESH:"Huntington Disease") - pmid:23746257 + pubmed:30027901 - bp(GO:"'de novo' protein folding") association act(p(HGNCGENEFAMILY:Chaperonins)) + a(CHEBI:fluoxetine) causesNoChange bp(GO:cognition) - pmid:23746257 + pubmed:26979166 - bp(GO:"'de novo' protein folding") association act(p(FPLX:HSPA)) + path(MESH:Affect) positiveCorrelation a(CHEBI:monoamine) - pmid:23746257 + pubmed:21787755 - bp(GO:"'de novo' protein folding") association act(p(FPLX:HSPA)) + path(MESH:Affect) association p(CONSO:"alpha-6-containing nAChR") + + - pmid:23746257 + pubmed:30935091 - bp(GO:"'de novo' protein folding") association act(p(FPLX:HSP90)) + p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006468 ! "protein phosphorylation")) increases complex(complex(GO:"proteasome complex"), p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006468 ! "protein phosphorylation"))) + + - pmid:27491084 + pubmed:30935091 - bp(HBP:misfolding) association p(FPLX:HSPB) + p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006468 ! "protein phosphorylation")) increases complex(complex(GO:"SCF ubiquitin ligase complex"), p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006468 ! "protein phosphorylation"))) - - - pmid:24563850 - - bp(HBP:misfolding) increases path(MESH:"Protein Aggregation, Pathological") - + - pmid:27491084 + pubmed:30935091 - p(HGNC:HSPB1) association a(HBP:"amyloid-beta aggregates") + p(HGNCGENEFAMILY:"Beta catenins") increases tloc(p(HGNCGENEFAMILY:"Beta catenins"), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) + + - pmid:21882945 + pubmed:30935091 - p(HGNC:HSPB1) increases bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") + p(HGNCGENEFAMILY:"Beta catenins", loc(GO:nucleus)) increases complex(p(HGNCGENEFAMILY:"Beta catenins"), p(HGNCGENEFAMILY:"TCF/LEF transcription factor family")) + + + + + + + + + + + + + + + + - pmid:21882945 + pubmed:30935091 - p(HGNC:HSPB1) increases bp(GO:"proteasomal protein catabolic process") + p(HGNCGENEFAMILY:"Beta catenins") increases bp(GO:"dendrite development") - pmid:21882945 + pubmed:30935091 - p(HGNC:HSPB1) increases bp(GO:autophagy) + p(HGNCGENEFAMILY:"Beta catenins") increases bp(GO:"neuronal signal transduction") - pmid:21882945 + pubmed:30935091 - p(HGNC:HSPB1) directlyIncreases complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) + p(HGNCGENEFAMILY:"Beta catenins") increases complex(complex(GO:"actin cytoskeleton"), p(HGNC:CDH2)) - pmid:21882945 + pubmed:30935091 - p(HGNC:HSPB1) directlyIncreases complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) + p(HGNCGENEFAMILY:"Beta catenins") increases bp(GO:"synaptic vesicle membrane organization") - pmid:14963027 + pubmed:30935091 - p(HGNC:HSPB1) increases complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) + p(HGNCGENEFAMILY:"Beta catenins") regulates bp(GO:"synaptic vesicle localization") + + + + - pmid:21882945 + pubmed:30935091 - p(HGNC:HSPB1) increases p(HGNC:MAPT) + complex(complex(GO:"proteasome complex"), p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006468 ! "protein phosphorylation"))) increases deg(p(HGNCGENEFAMILY:"Beta catenins")) - pmid:21882945 + pubmed:30935091 - p(HGNC:HSPB1) decreases p(HGNC:MAPT) + complex(complex(GO:"SCF ubiquitin ligase complex"), p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006468 ! "protein phosphorylation"))) increases deg(p(HGNCGENEFAMILY:"Beta catenins")) + + - pmid:14963027 + pubmed:14556719 - p(HGNC:HSPB1) causesNoChange p(HGNC:MAPT) + complex(GO:"SCF ubiquitin ligase complex") increases p(HGNC:CCNE1, pmod(go:0016567 ! "protein ubiquitination")) - pmid:21882945 + pubmed:30935091 - p(HGNC:HSPB1) directlyIncreases complex(a(MESH:"Neurofibrillary Tangles"), p(HGNC:HSPB1)) + complex(p(HGNC:LRP1), p(HGNCGENEFAMILY:"Wnt family")) increases p(HGNC:AXIN1) + + + + + + - pmid:21882945 + pubmed:26195256 - p(HGNC:HSPB1) positiveCorrelation bp(GO:"long-term synaptic potentiation") + p(HGNC:LRP1) increases tloc(a(CHEBI:amyloid-beta), fromLoc(MESH:Brain), toLoc(MESH:Blood)) - pmid:14963027 + pubmed:26195256 - p(HGNC:HSPB1) association p(HGNC:MAPT, pmod(Ph)) + p(HGNC:LRP1) increases tloc(a(CHEBI:amyloid-beta), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:Brain)) - pmid:14963027 + pubmed:26195256 - p(HGNC:HSPB1) decreases act(p(HGNC:MAPT, pmod(Ph))) + p(HGNC:LRP1) increases tloc(a(CHEBI:amyloid-beta), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Cardiovascular System")) - pmid:14963027 + pubmed:29626319 - p(HGNC:HSPB1) negativeCorrelation bp(GO:"neuron apoptotic process") + p(HGNC:LRP1) increases tloc(a(CHEBI:amyloid-beta), fromLoc(MESH:Brain), toLoc(MESH:Blood)) - pmid:27491084 + pubmed:29626319 - p(HGNC:CRYAB) association a(HBP:"amyloid-beta aggregates") + p(HGNC:LRP1) increases deg(a(CHEBI:amyloid-beta)) - pmid:27491084 + pubmed:29626319 - p(HGNC:HSPB6) association a(HBP:"amyloid-beta aggregates") + p(HGNC:LRP1) increases deg(a(CHEBI:amyloid-beta)) - pmid:27491084 + pubmed:26195256 - p(HGNC:HSF1) increases bp(HBP:Proteostasis) + p(HGNC:LRP1) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:21882945 + pubmed:26195256 - p(HGNC:HSF1) increases bp(HBP:Proteostasis) + p(HGNC:LRP1) increases tloc(p(HGNC:APOE), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Cardiovascular System")) + + + + - pmid:23746257 + pubmed:30935091 - p(HGNC:HSF1) regulates bp(GO:"cellular response to stress") + p(HGNC:AXIN1) increases deg(complex(p(HGNC:APC), p(HGNC:AXIN1), p(HGNC:GSK3B), p(HGNCGENEFAMILY:"Beta catenins"))) - pmid:23746257 + pubmed:30935091 - p(HGNC:HSF1) increases a(MESH:"Molecular Chaperones") + p(HGNC:AXIN1) increases p(HGNCGENEFAMILY:"Beta catenins") + + - pmid:25784053 + pubmed:30935091 - act(p(HGNC:HSF1), ma(tscript)) increases a(MESH:"Molecular Chaperones") + complex(p(HGNCGENEFAMILY:"Beta catenins"), p(HGNCGENEFAMILY:"TCF/LEF transcription factor family")) increases bp(GO:"mRNA transcription") + + - pmid:23746257 + pubmed:30935091 - p(HGNC:HSF1) decreases a(MESH:"Protein Aggregates") + path(EFO:"Thyroid Gland Undifferentiated (Anaplastic) Carcinoma") increases p(HGNCGENEFAMILY:"Beta catenins", var("p.Lys49Arg")) - pmid:25784053 + pubmed:30935091 - act(p(HGNC:HSF1)) increases tloc(p(HGNC:HSF1), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) + p(HGNCGENEFAMILY:"Beta catenins", var("p.Lys49Arg")) increases p(HGNCGENEFAMILY:"Beta catenins", loc(GO:nucleus)) + + + pubmed:30935091 + + p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006473 ! "protein acetylation", Lys, 49)) decreases act(p(HGNC:EGF)) + + - pmid:25784053 + pubmed:30935091 - act(p(HGNC:HSF1)) association path(MESH:Neoplasms) + p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006473 ! "protein acetylation", Lys, 49)) decreases p(HGNCGENEFAMILY:"Beta catenins", loc(GO:nucleus)) - pmid:24563850 + pubmed:30935091 - p(HGNC:HSF1) increases a(MESH:"Heat-Shock Proteins") + p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0016567 ! "protein ubiquitination", Lys, 49)) increases deg(p(HGNCGENEFAMILY:"Beta catenins")) - pmid:21882945 + pubmed:30935091 - p(HGNC:HSF1) increases a(MESH:"Heat-Shock Proteins") + complex(p(HGNC:CDH2), p(HGNCGENEFAMILY:"Beta catenins")) increases bp(GO:"cell-cell adhesion") + + + pubmed:30935091 + + complex(p(HGNC:CDH2), p(HGNCGENEFAMILY:"Beta catenins")) increases p(HGNCGENEFAMILY:"PDZ domain containing") + + + + + + - pmid:30116051 + pubmed:30935091 - act(p(HGNC:HSF1), ma(tscript)) increases act(p(FPLX:HSPA)) + a(CHEBI:ketamine) increases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser)) - pmid:27491084 + pubmed:30935091 - a(PUBCHEM:40009526) decreases complex(a(CHEBI:ATP), p(HGNC:HSPA1A)) + p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser)) isA a(MESH:"Antidepressive Agents") - pmid:27491084 + pubmed:30935091 - a(PUBCHEM:40009526) decreases complex(a(CHEBI:ATP), p(HGNC:HSPA1B)) + p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser)) decreases act(p(HGNC:GSK3B)) - + + + pubmed:30935091 + + a(CHEBI:ketanserin) decreases p(HGNC:HTR2A) + - pmid:25784053 + pubmed:30935091 - p(HGNC:HSPA1A) negativeCorrelation path(MESH:"Protein Aggregation, Pathological") + a(CHEBI:ketanserin) increases p(HGNCGENEFAMILY:"Beta catenins", loc(GO:"plasma membrane")) - pmid:22817713 + pubmed:30935091 - p(HGNC:HSPA1A) decreases a(HBP:"Tau aggregates") + a(CHEBI:ketanserin) causesNoChange p(HGNCGENEFAMILY:"Beta catenins", loc(GO:nucleus)) - pmid:22817713 + pubmed:30935091 - p(HGNC:HSPA1A) increases deg(a(HBP:"Tau aggregates")) + a(CHEBI:ketanserin) increases p(HGNC:CDH2) @@ -109457,2464 +110668,2564 @@

Statements

- pmid:25784053 + pubmed:30935091 - p(HGNC:HSPA1B) negativeCorrelation path(MESH:"Protein Aggregation, Pathological") + bp(GO:"synapse assembly") association p(HGNC:HDAC6) - pmid:29758300 + pubmed:30935091 - bp(GO:macroautophagy) negativeCorrelation path(MESH:"Alzheimer Disease") + bp(GO:"synapse assembly") positiveCorrelation p(HGNC:AKT1) - pmid:29758300 + pubmed:21214928 - bp(GO:macroautophagy) negativeCorrelation path(MESH:"Alzheimer Disease") + bp(GO:"synapse assembly") association p(HGNC:APP) - pmid:29758300 + pubmed:30106381 - bp(GO:macroautophagy) negativeCorrelation path(MESH:"Alzheimer Disease") + bp(GO:"synapse assembly") association p(HGNC:ADNP) - pmid:29758300 + pubmed:27807169 - bp(GO:macroautophagy) negativeCorrelation path(MESH:"Alzheimer Disease") + bp(GO:"synapse assembly") positiveCorrelation p(RGD:Cdk5r2) - pmid:25784053 + pubmed:30935091 - bp(GO:macroautophagy) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:AKT1) positiveCorrelation bp(GO:"synapse assembly") - pmid:29758300 + pubmed:30935091 - bp(GO:macroautophagy) increases deg(a(HBP:"protein aggregates")) + p(HGNC:AKT1) increases bp(GO:"dendritic spine morphogenesis") + + + + - pmid:29758300 + pubmed:30935091 - bp(GO:macroautophagy) increases deg(a(HBP:"protein aggregates")) + act(p(HGNC:AKT1), ma(GO:"phosphatidylinositol-3,4,5-trisphosphate binding")) increases p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006468 ! "protein phosphorylation", Ser, 552)) - pmid:27181519 + pubmed:29661268 - bp(GO:macroautophagy) increases deg(a(HBP:"protein aggregates")) + act(p(HGNC:AKT1), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:29758300 + pubmed:22530628 - bp(GO:macroautophagy) regulates a(CHEBI:"amyloid-beta") + act(p(HGNC:AKT1)) causesNoChange a(CONSO:"amyloid-beta aggregates") - pmid:29758300 + pubmed:22530628 - bp(GO:macroautophagy) negativeCorrelation a(CHEBI:"amyloid-beta") + act(p(HGNC:AKT1)) decreases bp(GO:"neuron death") - pmid:29758300 + pubmed:22530628 - bp(GO:macroautophagy) increases deg(a(CHEBI:"amyloid-beta")) + act(p(HGNC:AKT1)) increases bp(MESH:"Neuronal Plasticity") - pmid:29758300 + pubmed:22530628 - bp(GO:macroautophagy) regulates a(CHEBI:"amyloid-beta") + p(HGNC:AKT1) increases bp(MESH:"Neuronal Plasticity") - pmid:29758300 + pubmed:22530628 - bp(GO:macroautophagy) increases sec(a(CHEBI:"amyloid-beta")) + act(p(HGNC:AKT1)) increases bp(MESH:"Long-Term Potentiation") - pmid:29758300 + pubmed:22530628 - bp(GO:macroautophagy) increases sec(a(CHEBI:"amyloid-beta")) + act(p(HGNC:AKT1)) increases p(HGNC:BCL2) - pmid:29758300 + pubmed:22530628 - bp(GO:macroautophagy) association p(HGNC:BECN1) + act(p(HGNC:AKT1)) increases p(HGNC:CREBBP) - pmid:29758300 + pubmed:22530628 - bp(GO:macroautophagy) increases path(MESH:"Plaque, Amyloid") + act(p(HGNC:AKT1)) increases p(HGNC:DBF4) - pmid:29758300 + pubmed:22530628 - bp(GO:macroautophagy) increases deg(a(HBP:"Tau aggregates")) + p(HGNC:AKT1) increases bp(GO:cognition) - pmid:29758300 + pubmed:22530628 - bp(GO:macroautophagy) increases deg(a(CHEBI:triglyceride)) + p(HGNC:AKT1) increases bp(GO:"learning or memory") + + + + - pmid:29758300 + pubmed:29428175 - bp(GO:macroautophagy) negativeCorrelation path(MESH:"Parkinson Disease") + act(p(HGNC:AKT1), ma(GO:"GTPase activity")) regulates bp(MESH:"Cell Movement") - pmid:29758300 + pubmed:26979166 - bp(GO:macroautophagy) negativeCorrelation path(MESH:"Niemann-Pick Disease, Type C") + act(p(HGNC:AKT1)) directlyIncreases act(p(HGNC:CREB1)) + + + + + + + + - pmid:29758300 + pubmed:30606258 - bp(GO:macroautophagy) negativeCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") + act(p(HGNC:AKT1)) decreases p(HGNC:GSK3B) - pmid:29758300 + pubmed:30606258 - bp(GO:macroautophagy) negativeCorrelation path(MESH:"Bulbo-Spinal Atrophy, X-Linked") + act(p(HGNC:AKT1)) association bp(GO:"regulation of insulin receptor signaling pathway") - pmid:29758300 + pubmed:26968346 - bp(GO:macroautophagy) negativeCorrelation path(MESH:"Spastic Paraplegia, Hereditary") + p(HGNC:AKT1) decreases p(HGNC:TFEB) - pmid:22908190 + pubmed:21882945 - bp(GO:macroautophagy) increases a(GO:autophagosome) + p(HGNC:AKT1) association complex(p(FPLX:HSP90), p(HGNC:STUB1)) - pmid:22908190 + pubmed:21882945 - bp(GO:macroautophagy) increases deg(p(HGNC:MAPT, frag("?"))) + p(HGNC:AKT1) negativeCorrelation deg(p(HGNC:MAPT)) - pmid:18930136 + pubmed:21367866 - bp(GO:macroautophagy) increases bp(GO:"autophagosome-lysosome fusion") + act(p(HGNC:AKT1), ma(go:0016301 ! "kinase activity")) positiveCorrelation complex(p(FPLX:HSP90), p(HGNC:CDC37)) - pmid:18930136 + pubmed:21367866 - bp(GO:macroautophagy) increases deg(p(HGNC:SNCA)) + act(p(HGNC:AKT1), ma(go:0016301 ! "kinase activity")) negativeCorrelation p(HGNC:CDC37) - pmid:30116051 + pubmed:30935091 - bp(GO:macroautophagy) increases deg(p(HGNC:MAPT, pmod(Ph))) + p(HGNCGENEFAMILY:"Beta catenins", pmod(go:0006468 ! "protein phosphorylation", Ser, 552)) increases p(HGNCGENEFAMILY:"Beta catenins", loc(GO:"plasma membrane")) - pmid:29024336 + pubmed:30270813 - bp(GO:macroautophagy) increases deg(p(MGI:Mapt)) + a(CHEBI:cisplatin) negativeCorrelation path(EFO:neoplasm) - pmid:29024336 + pubmed:30270813 - bp(GO:macroautophagy) decreases deg(p(MGI:Mapt)) + a(CHEBI:cisplatin) decreases path(MESH:"Spatial Memory") - pmid:29024336 + pubmed:30270813 - bp(GO:macroautophagy) increases deg(p(MGI:Mapt, var("p.Ala152Thr"))) + a(CHEBI:cisplatin) decreases path(MESH:"Spatial Memory") - pmid:29024336 + pubmed:30270813 - bp(GO:macroautophagy) decreases deg(p(MGI:Mapt, var("p.Pro301Leu"))) + a(CHEBI:cisplatin) increases path(EFO:"peripheral neuropathy") - pmid:29024336 + pubmed:30270813 - bp(GO:macroautophagy) causesNoChange deg(p(MGI:Mapt, var("p.Pro301Leu"))) + a(CHEBI:cisplatin) negativeCorrelation bp(GO:cognition) - pmid:29024336 + pubmed:30270813 - bp(GO:macroautophagy) increases deg(a(MESH:Proteins)) + a(CHEBI:cisplatin) causesNoChange bp(GO:"locomotory behavior") - pmid:26751493 + pubmed:30270813 - bp(GO:macroautophagy) decreases p(HGNC:MAPT) + a(CHEBI:cisplatin) decreases path(MESH:"Executive Function") - pmid:27181519 + pubmed:30270813 - bp(GO:macroautophagy) isA bp(GO:"selective autophagy") + a(CHEBI:cisplatin) decreases path(MESH:"Problem Solving") - pmid:27181519 + pubmed:30270813 - bp(GO:macroautophagy) increases deg(complex(GO:"cytoplasmic stress granule")) + a(CHEBI:cisplatin) decreases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) - pmid:27181519 + pubmed:30270813 - bp(GO:macroautophagy) increases deg(complex(GO:"cytoplasmic stress granule")) + a(CHEBI:cisplatin) causesNoChange p(HGNC:HDAC6) - + + + pubmed:30270813 + + a(CHEBI:cisplatin) increases bp(MESH:"Mitochondrial Size") + - pmid:22908190 + pubmed:30270813 - a(HBP:"dystrophic neurite") association a(HBP:"paired helical filaments") + a(CHEBI:cisplatin) negativeCorrelation bp(GO:"cristae formation") - pmid:22908190 + pubmed:30270813 - a(HBP:"dystrophic neurite") association a(MESH:Ubiquitin) + a(CHEBI:cisplatin) decreases path(MESH:"Energy Metabolism") - pmid:22908190 + pubmed:30270813 - a(HBP:"dystrophic neurite") association a(GO:autophagosome) + a(CHEBI:cisplatin) decreases path(EFO:"maximal oxygen uptake measurement") - pmid:22908190 + pubmed:30270813 - a(HBP:"dystrophic neurite") positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:cisplatin) causesNoChange bp(GO:"respiratory gaseous exchange by respiratory system") - pmid:23531502 + pubmed:30270813 - a(HBP:"dystrophic neurite") association act(a(CHEBI:acrolein)) + a(CHEBI:cisplatin) causesNoChange bp(GO:"cellular respiration") - pmid:28877763 + pubmed:30270813 - a(HBP:"dystrophic neurite") association path(MESH:"Plaque, Amyloid") + a(CHEBI:cisplatin) decreases p(HGNC:SYP) - pmid:24401760 + pubmed:30270813 - a(HBP:"dystrophic neurite") association path(MESH:"Plaque, Amyloid") + a(CHEBI:cisplatin) decreases p(HGNC:DLG4) - pmid:24401760 + pubmed:30270813 - a(HBP:"dystrophic neurite") positiveCorrelation p(HGNC:ITPKB) + a(CHEBI:cisplatin) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:29758300 + pubmed:30270813 - a(GO:autolysosome) positiveCorrelation path(MESH:"Alzheimer Disease") + path(EFO:neoplasm) negativeCorrelation a(CHEBI:cisplatin) - pmid:18930136 + pubmed:18305152 - a(GO:autolysosome) positiveCorrelation path(MESH:"Huntington Disease") + path(EFO:neoplasm) association p(HGNC:CDK6) - pmid:18930136 + pubmed:30270813 - a(GO:autolysosome) decreases path(HBP:Neurodegeneration) + a(PUBCHEM:91844718) increases path(MESH:"Spatial Memory") - - - pmid:29758300 + pubmed:30270813 - p(HGNC:BECN1, frag("?")) association a(GO:"neurofibrillary tangle") + a(PUBCHEM:91844718) increases path(MESH:"Spatial Memory") - pmid:30116051 + pubmed:30270813 - p(HGNC:BECN1, frag("?")) decreases act(p(HGNC:BECN1)) + a(PUBCHEM:91844718) decreases path(EFO:"peripheral neuropathy") - pmid:29758300 + pubmed:30270813 - bp(GO:"regulation of lysosomal lumen pH") association p(HGNC:PSEN1) + a(PUBCHEM:91844718) causesNoChange bp(GO:"locomotory behavior") - pmid:26702100 + pubmed:30270813 - a(MESH:"Vacuolar Proton-Translocating ATPases") association a(GO:lysosome) + a(PUBCHEM:91844718) decreases p(HGNC:HDAC6) - pmid:22908190 + pubmed:30270813 - a(GO:lysosome) increases deg(p(MESH:Proteins, pmod(Ub))) + a(PUBCHEM:91844718) increases path(MESH:"Executive Function") - pmid:22908190 + pubmed:30270813 - a(GO:lysosome) increases deg(p(HGNC:MAPT)) + a(PUBCHEM:91844718) increases path(MESH:"Problem Solving") - pmid:22908190 + pubmed:30270813 - a(GO:lysosome) positiveCorrelation path(MESH:"Alzheimer Disease") + a(PUBCHEM:91844718) increases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation")) - pmid:22908190 + pubmed:30270813 - act(a(GO:lysosome)) negativeCorrelation path(MESH:"Alzheimer Disease") + a(PUBCHEM:91844718) regulates bp(MESH:"Mitochondrial Size") - pmid:22908190 + pubmed:30270813 - a(GO:lysosome) increases a(GO:organelle) + a(PUBCHEM:91844718) positiveCorrelation bp(GO:"cristae formation") - pmid:18930136 + pubmed:30270813 - a(GO:lysosome) negativeCorrelation p(HGNC:CTSD) + a(PUBCHEM:91844718) increases path(MESH:"Energy Metabolism") - pmid:18930136 + pubmed:30270813 - act(a(GO:lysosome)) decreases path(HBP:Neurodegeneration) + a(PUBCHEM:91844718) increases path(EFO:"maximal oxygen uptake measurement") - pmid:18930136 + pubmed:30270813 - act(a(GO:lysosome)) increases a(GO:autophagosome) + a(PUBCHEM:91844718) causesNoChange bp(GO:"respiratory gaseous exchange by respiratory system") - pmid:18930136 + pubmed:30270813 - act(a(GO:lysosome)) increases a(GO:lysosome) + a(PUBCHEM:91844718) causesNoChange bp(GO:"cellular respiration") - pmid:18930136 + pubmed:30270813 - act(a(GO:lysosome)) negativeCorrelation path(MESH:"Neuronal Ceroid-Lipofuscinoses") + a(PUBCHEM:91844718) increases p(HGNC:SYP) - pmid:29024336 + pubmed:30270813 - a(GO:lysosome) increases deg(a(HBP:HBP00053)) + a(PUBCHEM:91844718) increases p(HGNC:DLG4) - pmid:29590627 + pubmed:30270813 - a(GO:lysosome) association p(HGNC:MAPT, var("p.Pro301Ser")) + a(PUBCHEM:91844718) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:29590627 + pubmed:24511233 - a(GO:lysosome) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + path(MESH:"Executive Function") association path(MESH:Schizophrenia) - pmid:29590627 + pubmed:30270813 - a(GO:lysosome) association a(HBP:"Tau aggregates") + bp(GO:"cristae formation") negativeCorrelation a(CHEBI:cisplatin) - pmid:29590627 + pubmed:30270813 - a(GO:lysosome) increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + bp(GO:"cristae formation") positiveCorrelation a(PUBCHEM:91844718) - pmid:23229893 + pubmed:30697142 - a(GO:lysosome) association p(HGNC:SUMO1) + p(HGNC:DLG4) increases bp(MESH:"Neuronal Plasticity") + + - pmid:26702100 + pubmed:30106381 - a(GO:lysosome) association p(HGNC:LAMP1) + p(HGNC:DLG4) regulates act(p(HGNC:ADNP)) - pmid:26702100 + pubmed:30664622 - a(GO:lysosome) association p(HGNC:LAMP1) + p(HGNC:DLG4) association act(p(HGNC:ADNP)) - pmid:26702100 + pubmed:30106381 - a(GO:lysosome) association p(HGNC:CD63) + p(HGNC:DLG4) regulates act(a(PUBCHEM:9832404)) - pmid:26702100 + pubmed:30664622 - a(GO:lysosome) association p(HGNCGENEFAMILY:Cathepsins) + p(HGNC:DLG4) association act(a(PUBCHEM:9832404)) - pmid:26702100 + pubmed:30106381 - a(GO:lysosome) association a(MESH:"Vacuolar Proton-Translocating ATPases") + p(HGNC:DLG4) association bp(GO:"regulation of synaptic plasticity") - pmid:24561250 + pubmed:24760868 - a(GO:lysosome) decreases act(complex(GO:"NLRP3 inflammasome complex")) + p(HGNC:DLG4) positiveCorrelation bp(GO:"long-term synaptic potentiation") - pmid:29758300 + pubmed:26751493 - p(MESH:Proteins, pmod(HBP:misfolding)) decreases bp(GO:"neuron cellular homeostasis") + p(HGNC:DLG4) association p(CONSO:"projection domain") + + + + - pmid:29758300 + pubmed:29540553 - p(MESH:Proteins, pmod(HBP:misfolding)) decreases a(MESH:Neurons) + p(MGI:Ep300) increases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation")) - pmid:14556719 + pubmed:29540553 - p(MESH:Proteins, pmod(HBP:misfolding)) increases bp(GO:"response to unfolded protein") + p(MGI:Ep300) increases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 163)) - pmid:24457024 + pubmed:29540553 - p(MESH:Proteins, pmod(HBP:misfolding)) increases bp(HBP:"protein aggregation") + p(MGI:Ep300) increases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 174)) - pmid:18930136 + pubmed:29540553 - p(MESH:Proteins, pmod(HBP:misfolding)) positiveCorrelation path(MESH:"Neurodegenerative Diseases") + p(MGI:Ep300) increases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 274)) - pmid:18930136 + pubmed:29540553 - p(MESH:Proteins, pmod(HBP:misfolding)) increases p(HGNC:SQSTM1) + p(MGI:Ep300) increases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 280)) - pmid:18930136 + pubmed:29540553 - p(MESH:Proteins, pmod(HBP:misfolding)) increases r(HGNC:SQSTM1) + p(MGI:Ep300) increases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 369)) + + - pmid:29758300 + pubmed:27041503 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(HBP:Neurodegeneration) + p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 274)) decreases bp(MESH:"Long-Term Potentiation") - pmid:18930136 + pubmed:27041503 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(HBP:Neurodegeneration) + p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 274)) decreases p(MGI:Wwc1) - pmid:29758300 + pubmed:27041503 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") decreases path(MESH:Tauopathies) + p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 274)) decreases bp(GO:"actin cytoskeleton reorganization") - pmid:29758300 + pubmed:29661268 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association a(HBP:"Tau aggregates") + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 174)) positiveCorrelation path(DOID:"Alzheimer's disease") - pmid:23528736 + pubmed:29661268 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association a(HBP:"Tau aggregates") + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 174)) positiveCorrelation path(DOID:"frontotemporal dementia") - pmid:29758300 + pubmed:29661268 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:SNCA)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 174)) positiveCorrelation path(DOID:"Niemann-Pick disease") - pmid:18930136 + pubmed:26631930 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:SNCA)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 174)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:18930136 + pubmed:26390242 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:SNCA)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 174)) decreases deg(p(HGNC:MAPT)) - pmid:14556719 + pubmed:26390242 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(MESH:"Parkinson Disease") + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 174)) decreases bp(GO:cognition) - pmid:14556719 + pubmed:26390242 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:PARK7)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 174)) increases path(CONSO:Neurodegeneration) - pmid:14556719 + pubmed:28173111 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(MESH:"Alzheimer Disease") + p(MGI:Syp) negativeCorrelation p(MGI:Dnm1l) - pmid:23528736 + pubmed:28173111 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(MESH:"Alzheimer Disease") + p(MGI:Syp) association act(complex(GO:"neuron to neuron synapse")) - pmid:14556719 + pubmed:29540553 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(MESH:"Prion Diseases") + composite(p(MGI:Mapt, var("p.Pro301Ser")), p(MGI:Sirt1)) increases p(MGI:Syp) - pmid:14556719 + pubmed:28669544 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation path(MESH:"Prion Diseases") + path(MESH:"Neuronal Plasticity") positiveCorrelation path(MESH:"Cognitive Dysfunction") - pmid:14556719 + pubmed:28669544 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation bp(GO:aging) + path(MESH:"Neuronal Plasticity") association path(DOID:"neurodegenerative disease") - pmid:14556719 + pubmed:28669544 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") decreases p(HGNC:PRNP, loc(MESH:Cytoplasm)) + path(MESH:"Neuronal Plasticity") directlyDecreases p(HGNC:MBP) - pmid:14556719 + pubmed:28669544 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:PRNP)) + path(MESH:"Neuronal Plasticity") directlyDecreases p(HGNC:DLG4) - pmid:14556719 + pubmed:29540553 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:SOD1, var("?"))) + composite(p(CONSO:"Tau antibody, MC1"), p(CONSO:"Tau fibrils"), p(MGI:Mapt, var("p.Pro301Ser"))) increases path(EFO:tauopathy) + + - pmid:14556719 + pubmed:29661268 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:SOD1, var("?"))) + bp(GO:"microtubule severing") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) - pmid:14556719 + pubmed:29661268 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:SOD1, var("?"))) + p(MESH:Phosphotransferases) association p(CONSO:"Tau aggregates", pmod(go:0006468 ! "protein phosphorylation")) - pmid:14556719 + pubmed:29661268 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") decreases a(HBP:"protein aggregates") + p(CONSO:"Tau aggregates", pmod(go:0006468 ! "protein phosphorylation")) association p(MESH:Phosphotransferases) - pmid:27181519 + pubmed:29661268 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") causesNoChange deg(a(HBP:"protein aggregates")) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys)) decreases p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination", Lys)) - pmid:14556719 + pubmed:29661268 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:HTT, frag("?"))) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys)) decreases deg(p(HGNC:MAPT)) - pmid:22908190 + pubmed:29661268 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(MESH:Proteins, pmod(Ub))) + p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination", Lys)) increases deg(p(HGNC:MAPT)) - pmid:22908190 + pubmed:29661268 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association bp(GO:"regulation of synaptic plasticity") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser), loc(CONSO:"KXGS motif")) positiveCorrelation act(p(HGNC:HDAC6)) + + - pmid:30116051 + pubmed:29661268 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:"regulation of synaptic plasticity") + p(HGNC:MAPT, var("p.Lys?Gln")) association p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) - pmid:22908190 + pubmed:29661268 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association bp(GO:learning) + p(HGNC:MAPT, var("p.Lys?Gln")) decreases deg(p(HGNC:MAPT)) - pmid:22908190 + pubmed:29661268 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association bp(GO:memory) + p(HGNC:MAPT, var("p.Lys?Gln")) negativeCorrelation bp(GO:memory) - pmid:30116051 + pubmed:29661268 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:memory) + p(HGNC:MAPT, var("p.Lys?Gln")) negativeCorrelation bp(GO:learning) - pmid:22908190 + pubmed:29661268 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:ARC)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 274)) positiveCorrelation path(DOID:"Alzheimer's disease") - pmid:22908190 + pubmed:29661268 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:"long-term memory") + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 274)) positiveCorrelation path(DOID:"Alzheimer's disease") - pmid:18930136 + pubmed:29661268 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") regulates bp(GO:"amino acid homeostasis") + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 274)) negativeCorrelation bp(GO:memory) - pmid:18930136 + pubmed:27041503 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:"cellular protein catabolic process") + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 274)) decreases bp(GO:memory) - pmid:29626319 + pubmed:29661268 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:"cellular protein catabolic process") + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 274)) negativeCorrelation bp(GO:"long-term synaptic potentiation") - pmid:18930136 + pubmed:29661268 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases rxn(reactants(a(MESH:Proteins)), products(a(CHEBI:oligopeptide))) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 274)) positiveCorrelation path(DOID:"frontotemporal dementia") - pmid:18930136 + pubmed:29661268 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:"ubiquitin recycling") + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 274)) positiveCorrelation path(DOID:"Niemann-Pick disease") - pmid:18930136 + pubmed:26751493 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") negativeCorrelation bp(GO:autophagy) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 274)) increases p(CONSO:"Tau aggregates") - pmid:18930136 + pubmed:26751493 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") decreases tloc(p(HGNC:WDFY3), fromLoc(GO:nucleus), toLoc(GO:cytoplasm)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 274)) positiveCorrelation p(CONSO:"Tau aggregates") - pmid:30116051 + pubmed:27041503 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:MAPT)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 274)) decreases bp(GO:"regulation of synaptic plasticity") - pmid:23528736 + pubmed:27041503 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association deg(p(HGNC:MAPT)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 274)) decreases p(HGNC:WWC1) - pmid:23528736 + pubmed:29661268 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") regulates deg(p(HGNC:MAPT)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 281)) positiveCorrelation path(DOID:"Alzheimer's disease") - pmid:25374103 + pubmed:29661268 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:MAPT)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 281)) negativeCorrelation bp(GO:memory) - pmid:30116051 + pubmed:27041503 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases bp(GO:"dendrite development") + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 281)) decreases bp(GO:memory) - pmid:23528736 + pubmed:29661268 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") association path(HP:Neurodegeneration) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 281)) negativeCorrelation bp(GO:"long-term synaptic potentiation") - pmid:29626319 + pubmed:29661268 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") regulates deg(a(MESH:Proteins)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 281), loc(CONSO:"microtubule-binding region")) increases bp(GO:"microtubule severing") - pmid:29626319 + pubmed:29661268 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(a(CHEBI:"amyloid-beta")) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 281), loc(CONSO:"microtubule-binding region")) increases p(CONSO:"Tau fibrils") - pmid:29626319 + pubmed:26631930 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(a(CHEBI:"amyloid-beta")) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 281)) decreases deg(p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 281))) - pmid:29626319 + pubmed:27041503 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") decreases p(HBP:"Tau oligomers", pmod(HBP:hyperphosphorylation)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 281)) decreases bp(GO:"regulation of synaptic plasticity") - pmid:27708431 + pubmed:27041503 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") increases deg(p(HGNC:MARK4)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 281)) decreases p(HGNC:WWC1) - pmid:27181519 + pubmed:29661268 - bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") causesNoChange deg(complex(GO:"cytoplasmic stress granule")) + p(HGNC:MAPT, var("p.Lys280Gln")) association p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) - pmid:29758300 + pubmed:29661268 - bp(GO:proteolysis) decreases bp(GO:"neuron death") + p(HGNC:MAPT, var("p.Lys280Gln")) decreases bp(GO:"microtubule bundle formation") - pmid:14556719 + pubmed:29661268 - bp(GO:proteolysis) association p(HGNC:UBA3) + p(HGNC:MAPT, var("p.Lys280Gln")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) - pmid:24027553 + pubmed:29661268 - bp(GO:proteolysis) increases bp(GO:autophagy) + p(HGNC:MAPT, var("p.Lys280Gln")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 212), pmod(go:0006468 ! "protein phosphorylation", Thr, 214)) - pmid:24027553 + pubmed:29661268 - bp(GO:proteolysis) decreases a(MESH:Autophagosomes) + p(HGNC:MAPT, var("p.Lys280Gln")) increases p(HGNC:MAPT) - pmid:29626319 + pubmed:28287136 - bp(GO:proteolysis) increases deg(a(CHEBI:"amyloid-beta")) + p(HGNC:MAPT, var("p.Lys280Gln")) increases a(CONSO:"Tau aggregates") - pmid:29758300 + pubmed:29661268 - p(MESH:"Amyloid beta-Peptides", pmod(HBP:misfolding)) increases path(MESH:"Alzheimer Disease") + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 259), loc(CONSO:"KXGS motif")) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser), pmod(go:0006468 ! "protein phosphorylation", Thr), loc(CONSO:"microtubule-binding region")) - - - pmid:29758300 + pubmed:29661268 - act(complex(GO:"TOR complex")) positiveCorrelation a(CHEBI:"amyloid-beta") + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 259), loc(CONSO:"KXGS motif")) decreases p(CONSO:"Tau aggregates") - pmid:29626319 + pubmed:26631930 - complex(GO:"TOR complex") increases bp(GO:"lysosomal microautophagy") + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 259)) increases deg(p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 259))) - pmid:29758300 + pubmed:26631930 - bp(GO:endocytosis) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 259)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:22908190 + pubmed:26631930 - bp(GO:endocytosis) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 259)) decreases a(CONSO:"Tau aggregates") - pmid:22908190 + pubmed:26192747 - bp(GO:endocytosis) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 259)) isA p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) - pmid:29758300 + pubmed:26192747 - bp(GO:endocytosis) association p(HGNC:BECN1) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 259)) partOf p(CONSO:"microtubule-binding region") - pmid:22908190 + pubmed:29661268 - bp(GO:endocytosis) increases tloc(a(GO:"intrinsic component of plasma membrane"), fromLoc(GO:"plasma membrane"), toLoc(GO:lysosome)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 353), loc(CONSO:"KXGS motif")) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser), pmod(go:0006468 ! "protein phosphorylation", Thr), loc(CONSO:"microtubule-binding region")) - pmid:22908190 + pubmed:29661268 - bp(GO:endocytosis) increases act(a(MESH:Neurons)) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 353), loc(CONSO:"KXGS motif")) decreases p(CONSO:"Tau aggregates") - pmid:22908190 + pubmed:26631930 - bp(GO:endocytosis) association bp(GO:"regulation of synaptic plasticity") + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 353)) increases deg(p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 353))) - pmid:22908190 + pubmed:26631930 - bp(GO:endocytosis) increases bp(GO:memory) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 353)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:22908190 + pubmed:26631930 - bp(GO:endocytosis) increases bp(GO:learning) + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 353)) decreases a(CONSO:"Tau aggregates") - pmid:22908190 + pubmed:29661268 - bp(GO:endocytosis) increases bp(MESH:"Synaptic Transmission") + act(p(HGNC:CDK2), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:22908190 + pubmed:12428809 - bp(GO:endocytosis) positiveCorrelation p(HGNC:APP) + p(HGNC:CDK2) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:22908190 + pubmed:8282104 - bp(GO:endocytosis) positiveCorrelation g(HBP:"APOE e4") + p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:22908190 + pubmed:8282104 - bp(GO:endocytosis) positiveCorrelation a(CHEBI:cholesterol) + p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) - pmid:22908190 + pubmed:8282104 - bp(GO:endocytosis) positiveCorrelation a(MESH:Proteins) + p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) - pmid:22908190 + pubmed:8282104 - bp(GO:endocytosis) positiveCorrelation a(CHEBI:lipid) + p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) - pmid:22908190 + pubmed:8282104 - bp(GO:endocytosis) negativeCorrelation bp(GO:"lysosomal protein catabolic process") + p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) - pmid:22908190 + pubmed:8282104 - bp(GO:endocytosis) positiveCorrelation a(CHEBI:"amyloid-beta") + p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 235)) - pmid:22908190 + pubmed:8282104 - bp(GO:endocytosis) positiveCorrelation a(CHEBI:"amyloid-beta") + p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 235)) - pmid:22908190 + pubmed:22072628 - bp(GO:endocytosis) positiveCorrelation act(a(GO:synapse)) + act(p(HGNC:CDK2), ma(go:0016301 ! "kinase activity")) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 235)) - pmid:22908190 + pubmed:8282104 - bp(GO:endocytosis) positiveCorrelation p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") + p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) - pmid:22908190 + pubmed:8282104 - bp(GO:endocytosis) positiveCorrelation tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:cytosol), toLoc(GO:lysosome)) + p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) - pmid:18930136 + pubmed:8282104 - bp(GO:endocytosis) increases a(GO:lysosome) + p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) - pmid:29590627 + pubmed:8282104 - bp(GO:endocytosis) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + p(HGNC:CDK2) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) - pmid:29590627 + pubmed:22072628 - bp(GO:endocytosis) increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + p(HGNC:CDK2) increases p(CONSO:"Tau epitope, AT180") - pmid:29590627 + pubmed:22072628 - bp(GO:endocytosis) increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + act(p(HGNC:CDK2), ma(go:0016301 ! "kinase activity")) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 212)) - pmid:28420982 + pubmed:22072628 - bp(GO:endocytosis) increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:endosome), toLoc(GO:lysosome)) + act(p(HGNC:CDK2), ma(go:0016301 ! "kinase activity")) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 217)) - pmid:29686391 + pubmed:18305152 - bp(GO:endocytosis) positiveCorrelation bp(GO:"mitotic G1 phase") + p(HGNC:CDK2) association act(p(HGNC:RB1)) - pmid:29758300 + pubmed:18305152 - p(HGNC:ATG7) increases bp(GO:macroautophagy) + p(HGNC:CDK2) regulates bp(GO:"cell cycle") - pmid:18930136 + pubmed:29661268 - p(HGNC:ATG7) decreases path(HBP:Neurodegeneration) + act(p(HGNC:MARK1), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - - - + + + pubmed:12428809 + + p(HGNC:MARK1) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + - pmid:29758300 + pubmed:26631930 - path(MESH:"Niemann-Pick Diseases") association p(HGNC:MAPT) + p(HGNC:MARK1) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:22908190 + pubmed:26631930 - path(MESH:"Niemann-Pick Diseases") positiveCorrelation p(HBP:"UBB+1") + p(HGNC:MARK1) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) - pmid:26751493 + pubmed:21311567 - path(MESH:"Niemann-Pick Diseases") positiveCorrelation p(HBP:"3R tau") + act(p(HGNC:MARK1)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) - pmid:26631930 + pubmed:22952452 - path(MESH:"Niemann-Pick Diseases") positiveCorrelation p(HBP:"3R tau") + act(p(HGNC:MARK1), ma(go:0016301 ! "kinase activity")) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) - pmid:26751493 + pubmed:23001711 - path(MESH:"Niemann-Pick Diseases") positiveCorrelation p(HGNC:PSEN1, var("p.Gly183Val")) + p(HGNC:MARK1) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) - pmid:26631930 + pubmed:17493042 - path(MESH:"Niemann-Pick Diseases") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 280)) + p(HGNC:MARK1) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser)) + + - pmid:29758300 + pubmed:21311567 - p(FPLX:MAPK) increases p(HGNC:MAPT, pmod(Ph)) + act(p(HGNC:MARK1)) decreases bp(GO:"microtubule polymerization") - pmid:29191965 + pubmed:29661268 - p(FPLX:MAPK) directlyIncreases p(HGNC:MAPT, pmod(Ph)) + act(p(MESH:"Cyclic AMP-Dependent Protein Kinases"), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:8702879 + pubmed:29661268 - act(p(FPLX:MAPK)) increases p(HGNC:SYN1, pmod(Ph, Ser, 62)) + act(p(MESH:"Protein Kinase C"), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:8702879 + pubmed:29661268 - act(p(FPLX:MAPK)) increases p(HGNC:SYN1, pmod(Ph, Ser, 67)) + act(p(HGNC:FYN), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:8702879 + pubmed:19293145 - act(p(FPLX:MAPK)) increases p(HGNC:SYN1, pmod(Ph, Ser, 551)) + p(HGNC:FYN) association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + pubmed:18680553 + + p(HGNC:FYN) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + - pmid:29758300 + pubmed:19293145 - composite(p(HGNC:HSPA8), p(HGNC:LAMP2)) increases tloc(p(HGNC:MAPT), fromLoc(GO:cytosol), toLoc(GO:lysosome)) + p(HGNC:FYN) increases bp(GO:cognition) - pmid:18930136 + pubmed:19293145 - p(HGNC:LAMP2) increases tloc(a(MESH:Proteins), fromLoc(GO:intracellular), toLoc(GO:lysosome)) + p(HGNC:FYN) increases act(p(FPLX:PI3K)) - pmid:30116051 + pubmed:19293145 - p(HGNC:LAMP2) increases bp(GO:"chaperone-mediated autophagy") + p(HGNC:FYN) increases p(HGNC:AGAP2, pmod(go:0006468 ! "protein phosphorylation")) - pmid:30116051 + pubmed:19293145 - p(HGNC:LAMP2) increases deg(p(HGNC:SNCA)) + p(HGNC:FYN) decreases bp(GO:"apoptotic process") - pmid:29758300 + pubmed:19293145 - p(HGNC:NBR1) association p(HGNC:MAPT) + p(HGNC:FYN) association bp(MESH:Neuroprotection) - pmid:27181519 + pubmed:19293145 - p(HGNC:NBR1) regulates bp(GO:macroautophagy) + p(HGNC:FYN) increases bp(MESH:Neuroprotection) - pmid:29758300 + pubmed:19293145 - p(HGNC:SNCA, pmod(HBP:misfolding)) increases a(HBP:"alpha-synuclein oligomers") + p(HGNC:FYN) association act(a(CHEBI:amyloid-beta)) + + - pmid:29758300 + pubmed:18680553 - a(HBP:"alpha-synuclein oligomers") increases path(HBP:neuroinflammation) + p(HGNC:FYN) increases complex(p(HGNC:FYN), p(HGNC:MAPT)) + + - pmid:29758300 + pubmed:19293145 - a(HBP:"alpha-synuclein oligomers") increases bp(GO:"cell death") + p(HGNC:FYN) increases complex(p(HGNC:FYN), p(HGNC:PTK2)) - pmid:30985105 + pubmed:19293145 - a(HBP:"alpha-synuclein oligomers") negativeCorrelation a(HBP:"alpha-synuclein aggregates") + p(HGNC:FYN) increases p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors", pmod(go:0006468 ! "protein phosphorylation")) - pmid:27716675 + pubmed:19293145 - path(HBP:neuroinflammation) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) + p(HGNC:FYN) increases p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors", pmod(go:0006468 ! "protein phosphorylation")) + + + + + + - pmid:27716675 + pubmed:24760868 - path(HBP:neuroinflammation) positiveCorrelation a(HBP:"Tau oligomers") + p(HGNC:FYN) positiveCorrelation bp(GO:"long-term synaptic potentiation") - + + + pubmed:30640040 + + p(HGNC:FYN) association a(PUBCHEM:4878) + - pmid:29758300 + pubmed:29191965 - complex(p(HGNC:LAMP2), p(HGNC:SNCA, var("p.Ala53Thr"))) decreases bp(GO:"lysosomal protein catabolic process") + p(HGNC:FYN) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr)) - pmid:14556719 + pubmed:26751493 - p(HGNC:SNCA, var("p.Ala53Thr")) association path(MESH:"Parkinson Disease") + p(HGNC:FYN) association p(CONSO:"projection domain") - pmid:28803412 + pubmed:26631930 - p(HGNC:SNCA, var("p.Ala53Thr")) increases path(MESH:"Parkinson Disease") + p(HGNC:FYN) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) - pmid:14556719 + pubmed:17493042 - p(HGNC:SNCA, var("p.Ala53Thr")) increases a(HBP:"alpha-synuclein fibrils") + p(HGNC:FYN) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) + + + pubmed:26631930 + + p(HGNC:FYN) increases p(HGNC:GRIN2B, pmod(go:0006468 ! "protein phosphorylation")) + + - pmid:29758300 + pubmed:18680553 - complex(p(HGNC:LAMP2), p(HGNC:SNCA, var("p.Ala30Pro"))) decreases bp(GO:"lysosomal protein catabolic process") + p(HGNC:FYN) association p(RGD:Mapt, frag("223_226")) - pmid:14556719 + pubmed:26751493 - p(HGNC:SNCA, var("p.Ala30Pro")) association path(MESH:"Parkinson Disease") + p(HGNC:FYN) association bp(GO:myelination) - pmid:28803412 + pubmed:29661268 - p(HGNC:SNCA, var("p.Ala30Pro")) increases path(MESH:"Parkinson Disease") + act(p(HGNC:ABL1), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:14556719 + pubmed:30116051 - p(HGNC:SNCA, var("p.Ala30Pro")) increases a(HBP:"alpha-synuclein fibrils") + p(HGNC:ABL1) decreases bp(GO:macroautophagy) - pmid:28803412 + pubmed:29191965 - p(HGNC:SNCA, var("p.Ala30Pro")) increases path(MESH:"Lewy Body Disease") + p(HGNC:ABL1) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr)) - pmid:29758300 + pubmed:26631930 - p(HGNC:TARDBP, pmod(HBP:misfolding)) positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") + p(HGNC:ABL1) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 394)) - pmid:29758300 + pubmed:17493042 - p(HGNC:TARDBP, pmod(HBP:misfolding)) positiveCorrelation path(MESH:"Frontotemporal Dementia") + p(HGNC:ABL1) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 394)) - pmid:29758300 + pubmed:23687953 - a(CHEBI:lipid) regulates bp(GO:"energy homeostasis") + act(p(HGNC:ABL1), ma(go:0016301 ! "kinase activity")) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 363)) + + - pmid:29758300 + pubmed:29661268 - a(CHEBI:lipid) regulates bp(GO:"intracellular signal transduction") + p(CONSO:"Tau epitope, AT8") increases complex(a(CONSO:pretangles), p(CONSO:"Tau epitope, AT8")) - pmid:29758300 + pubmed:25478017 - a(CHEBI:lipid) regulates bp(GO:macroautophagy) + p(CONSO:"Tau epitope, AT8") decreases a(CONSO:"Tau fibrils") - pmid:29758300 + pubmed:28784767 - a(CHEBI:lipid) regulates bp(GO:"amyloid-beta metabolic process") + p(CONSO:"Tau epitope, AT8") equivalentTo p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205), pmod(go:0006468 ! "protein phosphorylation", Thr, 208)) - pmid:29758300 + pubmed:28784767 - a(CHEBI:lipid) negativeCorrelation bp(GO:autophagy) + p(CONSO:"Tau epitope, AT8") increases a(CONSO:"Tau aggregates") - pmid:22908190 + pubmed:21734277 - a(CHEBI:lipid) positiveCorrelation act(p(HGNC:RAB5A)) + p(CONSO:"Tau epitope, AT8") decreases bp(GO:"anterograde axonal protein transport") - pmid:22908190 + pubmed:21734277 - a(CHEBI:lipid) positiveCorrelation bp(GO:endocytosis) + p(CONSO:"Tau epitope, AT8") causesNoChange bp(GO:"retrograde axonal protein transport") + + + pubmed:21734277 + + p(CONSO:"Tau epitope, AT8") causesNoChange p(CONSO:"phosphatase-activating domain") + + - pmid:24561250 + pubmed:23088643 - a(CHEBI:"fatty acid") increases act(complex(GO:"inflammasome complex")) + p(CONSO:"Tau epitope, AT8") association a(GO:"neurofibrillary tangle") + + + pubmed:23088643 + + p(CONSO:"Tau epitope, AT8") association a(MESH:"Neuropil Threads") + + + + + pubmed:23088643 + + p(CONSO:"Tau epitope, AT8") association path(MESH:"Plaque, Amyloid") + + - pmid:29758300 + pubmed:28784767 - rxn(reactants(a(MESH:Sphingomyelins)), products(a(CHEBI:ceramide))) increases a(CHEBI:"amyloid-beta") + p(CONSO:"Tau epitope, AT8") increases p(CONSO:"Tau aggregates") - pmid:29758300 + pubmed:27087442 - a(CHEBI:sphingolipid) regulates act(complex(GO:"gamma-secretase complex")) + p(CONSO:"Tau epitope, AT8") positiveCorrelation p(CONSO:"CDK5R1 p25") + + + pubmed:22253473 + + p(CONSO:"Tau epitope, AT8") positiveCorrelation a(MESH:Neuropil) + + + + + pubmed:20869593 + + p(CONSO:"Tau epitope, AT8") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) + + - pmid:29758300 + pubmed:20869593 - complex(a(CHEBI:lipid), p(HGNC:MAPT)) increases a(HBP:"Tau aggregates") + p(CONSO:"Tau epitope, AT8") negativeCorrelation act(p(HGNC:SIRT1)) + + + pubmed:27574109 + + a(CONSO:pretangles) association a(CONSO:"Tau oligomers") + + - pmid:29758300 + pubmed:27574109 - complex(a(MESH:"Lipid Bilayers"), p(HGNC:MAPT)) association a(HBP:"Tau aggregates") + a(CONSO:pretangles) association p(CONSO:"phosphatase-activating domain") - pmid:29758300 + pubmed:27574109 - p(FPLX:AMPK) increases p(HGNC:ULK1, pmod(Ph)) + a(CONSO:pretangles) association p(HGNC:MAPT) - pmid:23528736 + pubmed:23407988 - p(FPLX:AMPK) increases p(HGNC:ULK1, pmod(Ph)) + a(CONSO:pretangles) increases complex(GO:"dendritic tree") - pmid:30116051 + pubmed:23088643 - p(FPLX:AMPK) increases bp(GO:macroautophagy) + a(CONSO:pretangles) association p(HGNC:TTBK1) - pmid:30116051 + pubmed:23088643 - act(p(FPLX:AMPK)) increases bp(GO:macroautophagy) + a(CONSO:pretangles) association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) - pmid:30116051 + pubmed:23088643 - act(p(FPLX:AMPK)) increases bp(GO:macroautophagy) + a(CONSO:pretangles) isA a(GO:"neurofibrillary tangle") + + - pmid:30116051 + pubmed:29661268 - p(FPLX:AMPK) decreases bp(GO:mitophagy) + p(CONSO:"Tau epitope, AT100") increases complex(a(CONSO:"Tau fibrils"), p(CONSO:"Tau epitope, AT100")) + + - pmid:30116051 + pubmed:4255369 - p(FPLX:AMPK) increases p(HGNC:ULK1, pmod(Ph, Ser, 317)) + a(CONSO:"Tau fibrils") positiveCorrelation bp(GO:aging) + + + + + + - pmid:30116051 + pubmed:28528849 - p(FPLX:AMPK) increases p(HGNC:ULK1, pmod(Ph, Ser, 777)) + a(CONSO:"Tau fibrils") causesNoChange a(MESH:"Dendritic Spines") - pmid:30116051 + pubmed:30108137 - p(FPLX:AMPK) increases p(FPLX:mTORC1, pmod(Ph)) + a(CONSO:"Tau fibrils", loc(GO:lysosome)) increases deg(p(MGI:Tfeb)) + + - pmid:30116051 + pubmed:29988016 - p(FPLX:AMPK) increases a(CHEBI:"NAD(+)") + a(CONSO:"Tau fibrils") increases a(CONSO:"Tau aggregates") + + - pmid:30116051 + pubmed:29686391 - act(p(FPLX:AMPK)) increases bp(GO:autophagy) + a(CONSO:"Tau fibrils") causesNoChange tloc(a(CONSO:"Tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:23528736 + pubmed:28420982 - p(FPLX:AMPK) increases bp(GO:autophagy) + a(CONSO:"Tau fibrils") increases a(GO:"neurofibrillary tangle") + + + pubmed:24869773 + + a(CONSO:"Tau fibrils") association p(HGNC:MAPT) + + - pmid:30116051 + pubmed:23088643 - act(p(FPLX:AMPK)) increases act(p(HGNC:SIRT1)) + a(CONSO:"Tau fibrils") association p(HGNC:TTBK1) + + + pubmed:23088643 + + a(CONSO:"Tau fibrils") increases a(CONSO:pretangles) + + - pmid:23528736 + pubmed:29661268 - p(FPLX:AMPK) decreases act(p(FPLX:mTORC1)) + a(CHEBI:"lithium atom") decreases p(HGNC:GSK3B) - pmid:22419736 + pubmed:29661268 - act(p(FPLX:AMPK)) association p(MESH:"Acetyl-CoA Carboxylase") + a(CHEBI:"lithium atom") decreases path(DOID:"bipolar disorder") - pmid:22419736 + pubmed:29661268 - act(p(FPLX:AMPK)) negativeCorrelation p(HGNC:MAPT, pmod(Ph)) + a(CHEBI:"lithium atom") positiveCorrelation bp(GO:cognition) - pmid:22419736 + pubmed:16340157 - p(FPLX:AMPK) negativeCorrelation p(HGNC:MAPT, pmod(Ph)) + a(CHEBI:"lithium atom") increases p(HGNC:HSPA5) - pmid:22419736 + pubmed:23528736 - act(p(FPLX:AMPK)) increases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) + a(CHEBI:"lithium atom") increases bp(GO:autophagy) - pmid:22419736 + pubmed:23528736 - act(p(FPLX:AMPK)) increases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) + a(CHEBI:"lithium atom") decreases p(HGNC:MAPT) - pmid:22419736 + pubmed:23528736 - act(p(FPLX:AMPK)) decreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + a(CHEBI:"lithium atom") decreases path(HP:"Neurofibrillary tangles") - pmid:22419736 + pubmed:27190210 - act(p(FPLX:AMPK)) decreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + path(DOID:"bipolar disorder") association g(HGNC:CHRNA7) - pmid:22419736 + pubmed:26979166 - act(p(FPLX:AMPK)) decreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + path(DOID:"bipolar disorder") increases path(MESH:Depression) - pmid:22419736 + pubmed:26979166 - act(p(FPLX:AMPK)) decreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + path(DOID:"bipolar disorder") increases path(NCIT:C78349) - pmid:22419736 + pubmed:26979166 - p(FPLX:AMPK) negativeCorrelation act(p(HGNC:GSK3B)) + path(DOID:"bipolar disorder") positiveCorrelation path(DOID:"diabetes mellitus") - pmid:24869773 + pubmed:26979166 - p(FPLX:AMPK) regulates complex(a(GO:microtubule), p(HGNC:MAPT)) + path(DOID:"bipolar disorder") positiveCorrelation path(DOID:obesity) + + + pubmed:26979166 + + path(DOID:"bipolar disorder") positiveCorrelation path(DOID:"cardiovascular system disease") + + + + + pubmed:26979166 + + path(DOID:"bipolar disorder") positiveCorrelation path(MESH:Smoking) + + - pmid:29758300 + pubmed:26979166 - composite(p(FPLX:AMPK), p(HGNC:TSC2)) decreases act(p(HGNC:MTOR)) + path(DOID:"bipolar disorder") positiveCorrelation path(MESH:Alcoholism) - pmid:29758300 + pubmed:26979166 - p(HGNC:TFEB) regulates a(GO:lysosome) + path(DOID:"bipolar disorder") increases bp(GO:"microglial cell activation") - pmid:29626319 + pubmed:26979166 - p(HGNC:TFEB) increases act(a(GO:lysosome)) + path(DOID:"bipolar disorder") association p(HGNC:CHRFAM7A, var("?")) - pmid:29626319 + pubmed:29661268 - p(HGNC:TFEB) increases act(a(GO:lysosome)) + act(p(HGNCGENEFAMILY:"Protein phosphatases")) decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:26702100 + pubmed:29661268 - act(p(HGNC:TFEB), ma(MESH:"Transcription, Genetic")) regulates a(GO:lysosome) + p(HGNC:PPA1) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:26702100 + pubmed:29661268 - p(HGNC:TFEB) increases a(GO:lysosome) + p(HGNC:PPP2CA) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:29758300 + pubmed:24653673 - p(HGNC:TFEB) regulates bp(GO:autophagy) + p(HGNC:PPP2CA) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:29758300 + pubmed:29191965 - p(HGNC:TFEB) increases bp(GO:autophagy) + p(HGNC:PPP2CA) directlyDecreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:29626319 + pubmed:26631930 - p(HGNC:TFEB) increases bp(GO:autophagy) + p(HGNC:PPP2CA) directlyDecreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:26702100 + pubmed:26631930 - p(HGNC:TFEB) regulates bp(GO:autophagy) + p(HGNC:PPP2CA) directlyDecreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:26702100 + pubmed:29661268 - act(p(HGNC:TFEB), ma(MESH:"Transcription, Genetic")) regulates bp(GO:autophagy) + act(p(HGNC:PPP2CA)) decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:29758300 + pubmed:29661268 - p(HGNC:TFEB) association path(MESH:"Alzheimer Disease") + act(p(HGNC:PPP2CA)) negativeCorrelation a(CHEBI:sirolimus) - - - pmid:29758300 - - p(HGNC:TFEB) increases deg(p(HGNC:MAPT, pmod(Ph))) - + - pmid:29626319 + pubmed:23454242 - p(HGNC:TFEB) regulates deg(p(HGNC:MAPT, pmod(Ph))) + p(HGNC:PPP2CA) association a(MESH:"Cell Membrane") - - - pmid:29758300 - - p(HGNC:TFEB) increases act(p(HGNC:PTEN)) - - - pmid:28803412 + pubmed:24653673 - p(HGNC:TFEB) decreases a(HBP:HBP00093) + p(HGNC:PPP2CA) association act(complex(GO:"protein phosphatase type 2A complex")) - pmid:30116051 + pubmed:10464280 - p(HGNC:TFEB) increases bp(GO:macroautophagy) + p(HGNC:PPP2CA) isA complex(GO:"protein phosphatase type 2A complex") - - - pmid:30116051 - - tloc(p(HGNC:TFEB), fromLoc(MESH:Cytoplasm), toLoc(MESH:"Cell Nucleus")) increases bp(GO:macroautophagy) - + - - - pmid:30116051 - - p(HGNC:TFEB) decreases path(MESH:"Plaque, Amyloid") - + - - - pmid:29626319 - - p(HGNC:TFEB) decreases path(MESH:"Plaque, Amyloid") - + - - - pmid:30108137 - - act(p(HGNC:TFEB, loc(GO:nucleus))) decreases act(a(MESH:Lysosomes)) - + - - - pmid:30108137 - - act(p(HGNC:TFEB, loc(GO:nucleus))) increases a(HBP:"protein aggregates") - + - pmid:29626319 + pubmed:19277525 - p(HGNC:TFEB) decreases a(CHEBI:"amyloid-beta") + p(HGNC:PPP2CA) association complex(p(HGNC:PPP2CA), p(INTERPRO:"HEAT repeat")) - pmid:29626319 + pubmed:19277525 - p(HGNC:TFEB) increases deg(a(CHEBI:"amyloid-beta")) + p(HGNC:PPP2CA) association p(HGNC:PPP2R1A) - - - pmid:29626319 - - p(HGNC:TFEB) regulates deg(a(CHEBI:"amyloid-beta")) - - - - - pmid:29626319 - - p(HGNC:TFEB) regulates deg(a(MESH:"Neurofibrillary Tangles")) - + - pmid:26702100 + pubmed:19277525 - p(HGNC:TFEB) association path(MESH:"Neurodegenerative Diseases") + p(HGNC:PPP2CA) causesNoChange complex(p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) @@ -111927,57 +113238,27 @@

Statements

- - - pmid:26702100 - - p(HGNC:TFEB, loc(GO:nucleus)) association act(p(HGNC:TFEB), ma(MESH:"Transcription, Genetic")) - + - - - pmid:26702100 - - act(p(HGNC:TFEB), ma(MESH:"Transcription, Genetic")) association p(HGNC:TFEB, loc(GO:nucleus)) - + - - - pmid:26702100 - - p(HGNC:TFEB) increases p(HGNC:MAP1LC3B) - + - - - pmid:26702100 - - p(HGNC:TFEB) increases a(GO:autophagosome) - + - - - pmid:29758300 - - p(HGNC:TFEB, pmod(Ph)) decreases act(p(HGNC:TFEB)) - + - - - pmid:26702100 - - p(HGNC:TFEB, pmod(Ph)) increases complex(p(HGNC:TFEB), p(HGNCGENEFAMILY:"14-3-3 phospho-serine/phospho-threonine binding proteins")) - + @@ -111985,83 +113266,73 @@

Statements

- - - pmid:29758300 - - complex(p(HGNC:TFEB), p(INTERPRO:"cAMP response element binding (CREB) protein")) increases bp(GO:macroautophagy) - + - pmid:29758300 + pubmed:24653673 - complex(p(HGNC:TFEB), p(INTERPRO:"cAMP response element binding (CREB) protein")) increases a(GO:lysosome) + p(HGNC:PPP2CA) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:29758300 + pubmed:26631930 - bp(GO:"cellular response to stress") increases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) + act(p(HGNC:PPP2CA)) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:29758300 + pubmed:24653673 - bp(GO:"cellular response to stress") increases complex(p(HGNC:TFEB), p(INTERPRO:"cAMP response element binding (CREB) protein")) + deg(p(HGNC:PPP2CA)) positiveCorrelation p(HGNC:IGBP1, frag("?")) - - - pmid:18930136 - - bp(GO:"cellular response to stress") increases p(HGNC:SQSTM1) - - - pmid:18930136 + pubmed:29626319 - bp(GO:"cellular response to stress") increases r(HGNC:SQSTM1) + p(HGNC:PPP2CA) increases bp(GO:autophagy) - pmid:21882945 + pubmed:10464280 - bp(GO:"cellular response to stress") increases a(MESH:"Heat-Shock Proteins") + p(HGNC:PPP2CA) association complex(GO:microtubule) + + - pmid:21882945 + pubmed:10464280 - bp(GO:"cellular response to stress") increases a(HBP:"Hsp27 oligomers") + p(HGNC:PPP2CA) increases complex(complex(GO:microtubule), p(HGNC:PPP2CA)) - pmid:29758300 + pubmed:29228318 - p(HGNC:PTEN) increases bp(GO:macroautophagy) + act(p(HGNC:PPP2CA)) directlyDecreases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) @@ -112072,822 +113343,823 @@

Statements

- pmid:29758300 + pubmed:19401603 - composite(p(HGNC:PTEN), p(HGNC:TFEB)) increases bp(GO:macroautophagy) + act(p(HGNC:PPP2CA)) directlyDecreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) - pmid:29758300 + pubmed:19401603 - p(HGNC:PICALM, var("?")) association path(MESH:"Alzheimer Disease") + act(p(HGNC:PPP2CA)) directlyDecreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 212)) - pmid:26195256 + pubmed:29661268 - p(HGNC:PICALM, var("?")) association path(MESH:"Alzheimer Disease") + p(HGNC:PPP3CA) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - - - pmid:29758300 + pubmed:27299292 - p(HGNC:PICALM) positiveCorrelation a(CHEBI:"amyloid-beta") + act(p(HGNC:PPP3CA), ma(go:0016791 ! "phosphatase activity")) decreases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation")) - pmid:29758300 + pubmed:27299292 - p(HGNC:PICALM) increases a(CHEBI:"amyloid-beta") + act(p(HGNC:PPP3CA), ma(go:0016791 ! "phosphatase activity")) increases act(p(HGNC:TFEB)) - pmid:29758300 + pubmed:27299292 - p(HGNC:PICALM) increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:"Endothelial Cells"), toLoc(MESH:Blood)) + act(p(HGNC:PPP3CA), ma(go:0016791 ! "phosphatase activity")) association bp(GO:"response to endoplasmic reticulum stress") - pmid:29626319 + pubmed:27299292 - p(HGNC:PICALM) increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:"Blood-Brain Barrier"), toLoc(MESH:Blood)) + p(HGNC:PPP3CA) association p(HGNC:EIF2AK3) - pmid:29626319 + pubmed:29661268 - p(HGNC:PICALM) decreases a(CHEBI:"amyloid-beta") + p(HGNCGENEFAMILY:"Protein phosphatases, Mg2+/Mn2+ dependent") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:29758300 + pubmed:29661268 - p(HGNC:PICALM) increases path(MESH:"Plaque, Amyloid") + p(MESH:Calcineurin) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:29758300 + pubmed:29661268 - p(HGNC:PICALM) increases bp(GO:"clathrin-dependent endocytosis") + p(HGNC:PPP5C) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:29758300 + pubmed:21882945 - p(HGNC:PICALM) increases tloc(complex(GO:"gamma-secretase complex"), fromLoc(GO:"extracellular space"), toLoc(GO:intracellular)) + p(HGNC:PPP5C) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:29758300 + pubmed:29311797 - p(HGNC:PICALM) regulates bp(GO:macroautophagy) + act(p(HGNC:PPP5C)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:29758300 + pubmed:26631930 - p(HGNC:PICALM) increases tloc(complex(GO:"SNARE complex"), fromLoc(GO:"extracellular space"), toLoc(GO:intracellular)) + p(HGNC:PPP5C) directlyDecreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + - pmid:29626319 + pubmed:21882945 - p(HGNC:PICALM) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:PPP5C) increases complex(a(GO:microtubule), p(HGNC:MAPT)) + + - pmid:27260836 + pubmed:29661268 - p(HGNC:PICALM) negativeCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:"okadaic acid") decreases act(p(HGNC:PPA1)) - pmid:27260836 + pubmed:29661268 - p(HGNC:PICALM) increases complex(p(HBP:"AP-2 complex"), p(HGNCGENEFAMILY:"Clathrin subunits")) + a(CHEBI:"okadaic acid") decreases act(p(HGNC:PPP2CA)) - pmid:27260836 + pubmed:19277525 - p(HGNC:PICALM) partOf complex(GO:"neurofibrillary tangle") + a(CHEBI:"okadaic acid") decreases act(p(HGNC:PPP2CA)) - pmid:27260836 + pubmed:29661268 - p(HGNC:PICALM) partOf complex(GO:"neurofibrillary tangle") + a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:27260836 + pubmed:22299660 - p(HGNC:PICALM) association p(HGNC:MAPT, pmod(Ph)) + a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:27260836 + pubmed:23454242 - p(HGNC:PICALM) association p(HGNC:MAPT, pmod(Ph)) + a(CHEBI:"okadaic acid") increases path(MESH:Neoplasms) - pmid:27260836 + pubmed:19277525 - p(HGNC:PICALM) partOf a(HBP:"granulovacuolar degeneration") + a(CHEBI:"okadaic acid") increases path(MESH:Neoplasms) - pmid:27260836 + pubmed:23454242 - p(HGNC:PICALM) partOf complex(GO:"Pick body") + a(CHEBI:"okadaic acid") decreases act(p(FPLX:PPP2C)) - pmid:27260836 + pubmed:19277525 - p(HGNC:PICALM) partOf complex(GO:"Cajal body") + a(CHEBI:"okadaic acid") decreases act(complex(GO:"protein phosphatase type 2A complex")) - pmid:27260836 + pubmed:24653673 - p(HGNC:PICALM) negativeCorrelation p(HGNC:MAP1LC3B) + a(CHEBI:"okadaic acid") decreases act(complex(GO:"protein phosphatase type 2A complex")) - pmid:27260836 + pubmed:24653673 - p(HGNC:PICALM) positiveCorrelation p(HGNC:BECN1) + a(CHEBI:"okadaic acid") decreases act(complex(GO:"protein phosphatase type 2A complex")) - pmid:29758300 + pubmed:19277525 - tloc(complex(GO:"SNARE complex"), fromLoc(GO:"extracellular space"), toLoc(GO:intracellular)) increases deg(a(HBP:"Tau aggregates")) + a(CHEBI:"okadaic acid") decreases act(p(HGNC:PPME1)) + + - pmid:29758300 + pubmed:24653673 - p(HGNC:BIN1) increases bp(GO:endocytosis) + a(CHEBI:"okadaic acid") increases complex(a(CHEBI:"okadaic acid"), p(HGNC:PPP2CA)) + + - pmid:29758300 + pubmed:24653673 - p(HGNC:BIN1) increases bp(GO:"amyloid precursor protein metabolic process") + a(CHEBI:"okadaic acid") increases complex(a(CHEBI:"okadaic acid"), p(HGNC:PPP2CB)) - pmid:29758300 + pubmed:24653673 - p(HGNC:BIN1) increases bp(GO:autophagy) + a(CHEBI:"okadaic acid") decreases bp(GO:cognition) - pmid:29758300 + pubmed:24653673 - p(HGNC:BIN1) decreases a(CHEBI:"amyloid-beta") + a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:29758300 + pubmed:24653673 - p(HGNC:BIN1) positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:"okadaic acid") increases bp(CONSO:amyloidogenesis) - pmid:29758300 + pubmed:24653673 - p(HGNC:BIN1) positiveCorrelation path(MESH:Tauopathies) + a(CHEBI:"okadaic acid") decreases a(GO:synapse) - pmid:29758300 + pubmed:24653673 - p(HGNC:TREM2) positiveCorrelation p(HGNC:MAPT) + a(CHEBI:"okadaic acid") increases path(CONSO:Neurodegeneration) - pmid:29758300 + pubmed:22299660 - p(HGNC:TREM2) positiveCorrelation p(HGNC:MAPT, pmod(Ph)) + a(CHEBI:"okadaic acid") decreases act(p(FPLX:PPP2)) - - - pmid:29758300 + pubmed:22299660 - p(HGNC:TREM2) increases bp(GO:macroautophagy) + a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 198)) - pmid:29758300 + pubmed:22299660 - p(HGNC:TREM2) increases bp(GO:"metabolic process") + a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) - pmid:29758300 + pubmed:22299660 - p(HGNC:TREM2) increases bp(GO:"metabolic process") + a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) - pmid:29758300 + pubmed:22299660 - p(HGNC:TREM2) increases act(complex(GO:"TOR complex")) + a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) - pmid:29626319 + pubmed:22299660 - p(HGNC:TREM2) association bp(GO:phagocytosis) + a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) - pmid:29626319 + pubmed:22299660 - act(p(HGNC:TREM2)) increases bp(GO:phagocytosis) + a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) - pmid:29626319 + pubmed:22299660 - act(p(HGNC:TREM2)) increases deg(a(CHEBI:"amyloid-beta polypeptide 42")) + a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) - - - pmid:29758300 + pubmed:22299660 - p(HGNC:TREM2, var("?")) increases path(MESH:"Alzheimer Disease") + a(CHEBI:"okadaic acid") decreases bp(GO:learning) - pmid:26195256 + pubmed:22299660 - p(HGNC:TREM2, var("?")) association path(MESH:"Alzheimer Disease") + a(CHEBI:"okadaic acid") decreases bp(GO:memory) - pmid:29758300 + pubmed:16464864 - p(HGNC:VPS35) regulates act(p(HGNC:TREM2)) + a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(go:0016925 ! "protein sumoylation", Lys, 340)) - - - pmid:29758300 + pubmed:29661268 - p(HGNC:VPS35) directlyIncreases complex(p(HGNC:SORL1), p(HGNC:VPS35)) + p(HGNC:ULK1, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation bp(GO:autophagy) - pmid:29758300 + pubmed:30061532 - p(HGNC:VPS35, var("?")) decreases bp(GO:macroautophagy) + p(HGNC:ULK1, pmod(go:0006468 ! "protein phosphorylation")) increases bp(GO:autophagy) + + - pmid:29758300 + pubmed:29661268 - p(HGNC:VPS35, var("?")) decreases act(a(GO:mitochondrion)) + p(HGNC:ULK1) positiveCorrelation bp(GO:autophagy) - pmid:29758300 + pubmed:23528736 - p(HGNC:VPS35, var("?")) association path(MESH:"Alzheimer Disease") + p(HGNC:ULK1) increases bp(GO:autophagy) - - - pmid:29758300 - - p(HGNC:VPS35, var("?")) association path(MESH:"Parkinson Disease") - + - pmid:29758300 + pubmed:30116051 - a(GO:mitochondrion) regulates bp(GO:"energy homeostasis") + p(HGNC:ULK1) increases bp(GO:macroautophagy) + + + + + + - pmid:27671637 + pubmed:30116051 - a(GO:mitochondrion) positiveCorrelation a(CHEBI:ATP) + act(p(HGNC:ULK1)) increases bp(GO:"autophagosome assembly") - pmid:23528736 + pubmed:30116051 - act(a(GO:mitochondrion)) increases a(CHEBI:"reactive oxygen species") + act(p(HGNC:ULK1)) increases p(HGNC:AMBRA1, pmod(go:0006468 ! "protein phosphorylation")) - pmid:25987199 + pubmed:30116051 - act(a(GO:mitochondrion)) positiveCorrelation act(p(MGI:Ppargc1a)) + act(p(HGNC:ULK1)) increases p(HGNC:BECN1, pmod(go:0006468 ! "protein phosphorylation")) - - - - - pmid:29758300 + pubmed:29661268 - p(HGNC:PSEN1, var("p.Met146Leu")) decreases bp(GO:autophagy) + a(CHEBI:nutrient) increases act(p(HGNC:MTOR)) - pmid:29758300 + pubmed:29661268 - p(HGNC:PSEN1, var("p.Ala246Glu")) decreases bp(GO:autophagy) + act(p(HGNC:MTOR)) decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:29758300 + pubmed:30061532 - p(HGNC:PSEN1, var("p.Ala246Glu")) decreases bp(GO:mitophagy) + act(p(HGNC:MTOR)) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:29758300 + pubmed:29661268 - p(HGNC:PSEN1, var("p.Ala246Glu")) decreases act(a(GO:lysosome)) + act(p(HGNC:MTOR)) decreases p(CONSO:"Tau aggregates") - pmid:29758300 + pubmed:30061532 - p(HGNC:MAPT, var("p.Ala152Thr")) positiveCorrelation p(HGNC:MAPT, pmod(Ph)) + act(p(HGNC:MTOR)) regulates deg(p(MESH:Proteins, pmod(CONSO:misfolded))) - pmid:29758300 + pubmed:30061532 - p(HGNC:MAPT, var("p.Ala152Thr")) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + act(p(HGNC:MTOR)) negativeCorrelation bp(GO:autophagy) - pmid:29758300 + pubmed:30061532 - p(HGNC:MAPT, var("p.Ala152Thr")) increases bp(GO:macroautophagy) + act(p(HGNC:MTOR)) decreases bp(GO:autophagy) - pmid:27594586 + pubmed:30061532 - p(HGNC:MAPT, var("p.Ala152Thr")) increases p(HGNC:MAP2) + p(HGNC:MTOR) decreases bp(GO:autophagy) - pmid:27594586 + pubmed:30106381 - p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange a(GO:"symmetric, GABA-ergic, inhibitory synapse") + p(HGNC:MTOR) association bp(GO:autophagy) - pmid:27594586 + pubmed:30027901 - p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange p(HGNC:SLC17A7) + p(HGNC:MTOR) decreases bp(GO:autophagy) - pmid:27594586 + pubmed:21722302 - p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange p(HGNC:MAPT) + p(HGNC:MTOR) regulates bp(GO:autophagy) - pmid:26631930 + pubmed:21722302 - p(HGNC:MAPT, var("p.Ala152Thr")) decreases act(p(HGNC:MAPT)) + act(p(HGNC:MTOR)) decreases bp(GO:autophagy) - pmid:27594586 + pubmed:21722302 - p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange p(HGNC:DLGAP4) + p(HGNC:MTOR) decreases bp(GO:autophagy) - pmid:27594586 + pubmed:26968346 - p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange bp(MESH:"Membrane Potentials") + act(p(HGNC:MTOR)) positiveCorrelation bp(GO:autophagy) - pmid:27594586 + pubmed:29758300 - p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange bp(GO:"neuron differentiation") + p(HGNC:MTOR) negativeCorrelation bp(GO:autophagy) - pmid:27594586 + pubmed:22908190 - p(HGNC:MAPT, var("p.Ala152Thr")) increases act(p(HGNC:MMP9)) + p(HGNC:MTOR) regulates bp(GO:autophagy) - pmid:27594586 + pubmed:18930136 - p(HGNC:MAPT, var("p.Ala152Thr")) increases sec(p(HGNC:MMP9)) + p(HGNC:MTOR) negativeCorrelation bp(GO:autophagy) - pmid:27594586 + pubmed:30061532 - p(HGNC:MAPT, var("p.Ala152Thr")) increases sec(p(HGNC:MMP9)) + act(p(HGNC:MTOR)) positiveCorrelation path(MESH:"Neurodegenerative Diseases") - pmid:27594586 + pubmed:30061532 - p(HGNC:MAPT, var("p.Ala152Thr")) increases act(p(HGNC:MMP9)) + act(p(HGNC:MTOR)) increases a(CHEBI:amyloid-beta) - pmid:27594586 + pubmed:30061532 - p(HGNC:MAPT, var("p.Ala152Thr")) increases sec(p(HGNC:MMP9)) + act(p(HGNC:MTOR)) increases path(MESH:"Alzheimer Disease") - pmid:27594586 + pubmed:30061532 - p(HGNC:MAPT, var("p.Ala152Thr")) increases sec(p(HGNC:MMP2)) + act(p(HGNC:MTOR)) increases a(CONSO:"Tau aggregates") - pmid:27594586 + pubmed:30061532 - p(HGNC:MAPT, var("p.Ala152Thr")) increases act(p(HGNC:MMP2)) + act(p(HGNC:MTOR)) decreases bp(GO:cognition) - pmid:27594586 + pubmed:30061532 - p(HGNC:MAPT, var("p.Ala152Thr")) increases sec(p(HGNC:MMP2)) + act(p(HGNC:MTOR)) association act(g(HGNC:DISC1)) - pmid:27594586 + pubmed:30061532 - p(HGNC:MAPT, var("p.Ala152Thr")) increases r(HGNC:MMP9) + act(p(HGNC:MTOR)) association act(g(HGNC:NRG1)) - pmid:27594586 + pubmed:30061532 - p(HGNC:MAPT, var("p.Ala152Thr")) increases r(HGNC:MMP9) + act(p(HGNC:MTOR)) association act(g(HGNC:DPYSL2)) - pmid:27594586 + pubmed:30061532 - p(HGNC:MAPT, var("p.Ala152Thr")) increases r(HGNC:MMP2) + act(p(HGNC:MTOR)) increases act(a(CHEBI:methamphetamine)) - pmid:27594586 + pubmed:30061532 - p(HGNC:MAPT, var("p.Ala152Thr")) increases r(HGNC:MMP2) + act(p(HGNC:MTOR)) association r(HGNC:MAP6) - pmid:27594586 + pubmed:30061532 - p(HGNC:MAPT, var("p.Ala152Thr")) increases bp(GO:"neuron death") + act(p(HGNC:MTOR)) association p(HGNC:MAP6) - pmid:27594586 + pubmed:30061532 - p(HGNC:MAPT, var("p.Ala152Thr")) increases p(FPLX:ERK, pmod(Ph)) + act(p(HGNC:MTOR)) association p(HGNC:NRG1) - pmid:27594586 + pubmed:30061532 - p(HGNC:MAPT, var("p.Ala152Thr")) increases a(HBP:HBP00045) + act(p(HGNC:MTOR)) association path(MESH:Schizophrenia) - pmid:27594586 + pubmed:30061532 - p(HGNC:MAPT, var("p.Ala152Thr")) decreases a(HBP:HBP00044) + act(p(HGNC:MTOR)) negativeCorrelation path(MESH:Schizophrenia) - pmid:29024336 + pubmed:30106381 - p(HGNC:MAPT, var("p.Ala152Thr")) decreases deg(p(MGI:Mapt)) + p(HGNC:MTOR) association bp(GO:translation) - pmid:29191965 + pubmed:30106381 - p(HGNC:MAPT, var("p.Ala152Thr")) association path(MESH:"Supranuclear Palsy, Progressive") + p(HGNC:MTOR) association a(GO:"actin cytoskeleton") - pmid:26631930 + pubmed:21722302 - p(HGNC:MAPT, var("p.Ala152Thr")) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") + p(HGNC:MTOR) negativeCorrelation p(HGNC:PRKAA1) - pmid:26631930 + pubmed:26968346 - p(HGNC:MAPT, var("p.Ala152Thr")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + p(HGNC:MTOR) decreases p(HGNC:TFEB) - pmid:26631930 + pubmed:29758300 - p(HGNC:MAPT, var("p.Ala152Thr")) decreases bp(GO:"microtubule polymerization") + p(HGNC:MTOR) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + - pmid:26631930 + pubmed:30985105 - p(HGNC:MAPT, var("p.Ala152Thr")) increases a(HBP:"Tau oligomers") + act(p(HGNC:MTOR)) increases p(HGNC:SNCA) @@ -112898,1765 +114170,1716 @@

Statements

- pmid:29758300 + pubmed:29661268 - composite(a(CHEBI:sirolimus), p(HGNC:MAPT, var("p.Ala152Thr"))) increases bp(GO:"cell death") + a(CHEBI:"carbon atom") increases act(p(HGNC:MTOR)) - pmid:27594586 + pubmed:29661268 - composite(a(CHEBI:sirolimus), p(HGNC:MAPT, var("p.Ala152Thr"))) increases bp(GO:"neuron death") + complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser)), p(HGNC:STUB1)) increases p(HGNC:MAPT) - pmid:29758300 + pubmed:29661268 - path(MESH:"Niemann-Pick Disease, Type C") negativeCorrelation bp(GO:macroautophagy) + complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser)), p(HGNC:STUB1)) increases p(CONSO:"Tau aggregates") - pmid:29758300 + pubmed:29661268 - path(MESH:"Bulbo-Spinal Atrophy, X-Linked") negativeCorrelation bp(GO:macroautophagy) + complex(p(CONSO:"paired helical filaments"), p(HGNC:MAPT)) increases complex(p(CONSO:"paired helical filaments"), p(HGNC:MAPT), p(MESH:"Proteasome Endopeptidase Complex")) - pmid:14556719 + pubmed:29661268 - path(MESH:"Bulbo-Spinal Atrophy, X-Linked") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) + complex(p(CONSO:"paired helical filaments"), p(HGNC:MAPT), p(MESH:"Proteasome Endopeptidase Complex")) decreases act(p(MESH:"Proteasome Endopeptidase Complex")) - pmid:14556719 + pubmed:29661268 - path(MESH:"Bulbo-Spinal Atrophy, X-Linked") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) + complex(p(CONSO:"paired helical filaments"), p(HGNC:MAPT), p(MESH:"Proteasome Endopeptidase Complex")) decreases deg(p(HGNC:MAPT)) + + - pmid:18930136 + pubmed:29661268 - path(MESH:"Bulbo-Spinal Atrophy, X-Linked") negativeCorrelation bp(GO:autophagy) + act(p(MESH:"Proteasome Endopeptidase Complex")) increases deg(p(MESH:Proteins)) - pmid:29758300 + pubmed:29661268 - path(MESH:"Spastic Paraplegia, Hereditary") negativeCorrelation bp(GO:macroautophagy) + act(p(MESH:"Proteasome Endopeptidase Complex")) increases deg(p(HGNC:MAPT)) + + - pmid:29758300 + pubmed:29661268 - a(CHEBI:Temsirolimus) increases bp(GO:macroautophagy) + p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination", Lys, 254), loc(CONSO:"microtubule-binding region")) decreases act(p(HGNC:MAPT), ma(GO:"microtubule binding")) - pmid:30116051 + pubmed:8391280 - a(CHEBI:Temsirolimus) decreases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination", Lys, 254)) positiveCorrelation a(CONSO:"paired helical filaments") - pmid:29626319 + pubmed:29661268 - a(CHEBI:Temsirolimus) decreases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination", Lys, 311), loc(CONSO:"microtubule-binding region")) decreases act(p(HGNC:MAPT), ma(GO:"microtubule binding")) - pmid:30116051 + pubmed:8391280 - a(CHEBI:Temsirolimus) decreases a(HBP:"huntingtin aggregates") + p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination", Lys, 311)) positiveCorrelation a(CONSO:"paired helical filaments") - pmid:30116051 + pubmed:29661268 - a(CHEBI:Temsirolimus) increases bp(GO:"motor behavior") + p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination", Lys, 353), loc(CONSO:"microtubule-binding region")) decreases act(p(HGNC:MAPT), ma(GO:"microtubule binding")) - pmid:30116051 + pubmed:29661268 - a(CHEBI:Temsirolimus) decreases a(HBP:"alpha-synuclein aggregates") + p(HGNC:MARCH7) increases p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) - pmid:30116051 + pubmed:24905733 - a(CHEBI:Temsirolimus) decreases bp(HP:Neurodegeneration) + p(HGNC:MARCH7) increases p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) - pmid:30116051 + pubmed:29661268 - a(CHEBI:Temsirolimus) decreases p(HGNC:ATXN3, var("?")) + composite(p(CONSO:"paired helical filaments"), p(MESH:"Proteasome Endopeptidase Complex")) decreases act(p(MESH:"Proteasome Endopeptidase Complex")) - pmid:29626319 + pubmed:30232325 - a(CHEBI:Temsirolimus) increases bp(GO:autophagy) + act(p(HGNC:WNT3A)) increases bp(GO:"canonical Wnt signaling pathway") - pmid:29626319 + pubmed:30232325 - a(CHEBI:Temsirolimus) decreases a(CHEBI:"amyloid-beta") + act(p(HGNC:WNT3A)) increases bp(GO:"canonical Wnt signaling pathway") - pmid:29758300 + pubmed:30232325 - a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:macroautophagy) + act(p(HGNC:WNT3A)) decreases a(CHEBI:amyloid-beta) - pmid:30116051 + pubmed:30232325 - a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:macroautophagy) + act(p(HGNC:WNT3A)) increases a(CHEBI:amyloid-beta) - pmid:18930136 + pubmed:30232325 - a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:autophagy) + bp(GO:"canonical Wnt signaling pathway") association p(HGNC:LRP6) - pmid:30145931 + pubmed:30232325 - a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:autophagy) + bp(GO:"canonical Wnt signaling pathway") decreases a(CHEBI:amyloid-beta) - pmid:23528736 + pubmed:30232325 - a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:autophagy) + bp(GO:"canonical Wnt signaling pathway") negativeCorrelation bp(GO:"amyloid-beta formation") - pmid:29626319 + pubmed:30232325 - a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:autophagy) + act(p(HGNC:WNT5A)) increases bp(GO:"Wnt signaling pathway, planar cell polarity pathway") - pmid:29626319 + pubmed:30232325 - a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:autophagy) + bp(GO:"Wnt signaling pathway, planar cell polarity pathway") association p(HGNC:VANGL2) - pmid:27181519 + pubmed:30232325 - a(CHEBI:"alpha,alpha-trehalose") association bp(GO:autophagy) + bp(GO:"Wnt signaling pathway, planar cell polarity pathway") increases a(CHEBI:amyloid-beta) - pmid:18930136 + pubmed:30232325 - a(CHEBI:"alpha,alpha-trehalose") decreases path(HBP:Neurodegeneration) + bp(GO:"Wnt signaling pathway, planar cell polarity pathway") positiveCorrelation bp(GO:"amyloid-beta formation") + + - pmid:30145931 + pubmed:30232325 - a(CHEBI:"alpha,alpha-trehalose") decreases p(HGNC:MAPT) + p(HGNC:VANGL2) association bp(GO:"Wnt signaling pathway, planar cell polarity pathway") - - - pmid:30145931 - - a(CHEBI:"alpha,alpha-trehalose") decreases p(HGNC:MAPT, loc(MESH:Dendrites)) - + - pmid:29626319 + pubmed:30232325 - a(CHEBI:"alpha,alpha-trehalose") decreases p(HGNC:MAPT) + p(HGNC:LRP6) association bp(GO:"canonical Wnt signaling pathway") + + - pmid:30145931 + pubmed:30232325 - a(CHEBI:"alpha,alpha-trehalose") decreases a(HBP:"Tau aggregates") + composite(p(HGNC:APP), p(HGNC:LRP6)) increases bp(GO:"canonical Wnt signaling pathway") - pmid:30116051 + pubmed:30232325 - a(CHEBI:"alpha,alpha-trehalose") decreases a(HBP:"Tau aggregates") + composite(p(HGNC:APP), p(HGNC:LRP6)) decreases bp(GO:"Wnt signaling pathway, planar cell polarity pathway") - pmid:23528736 + pubmed:30232325 - a(CHEBI:"alpha,alpha-trehalose") decreases a(HBP:"Tau aggregates") + composite(p(HGNC:APP), p(HGNC:LRP6)) decreases a(CHEBI:amyloid-beta) - pmid:30116051 + pubmed:30232325 - a(CHEBI:"alpha,alpha-trehalose") decreases act(p(HGNC:SLC2A9)) + composite(p(HGNC:APP), p(HGNC:VANGL2)) decreases bp(GO:"canonical Wnt signaling pathway") - pmid:30116051 + pubmed:30232325 - a(CHEBI:"alpha,alpha-trehalose") increases act(p(FPLX:AMPK)) + composite(p(HGNC:APP), p(HGNC:VANGL2)) increases bp(GO:"Wnt signaling pathway, planar cell polarity pathway") - pmid:30116051 + pubmed:30232325 - a(CHEBI:"alpha,alpha-trehalose") decreases bp(HP:Neurodegeneration) + composite(p(HGNC:APP), p(HGNC:VANGL2)) increases a(CHEBI:amyloid-beta) - pmid:30116051 + pubmed:30232325 - a(CHEBI:"alpha,alpha-trehalose") decreases a(HBP:"alpha-synuclein aggregates") + p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) decreases bp(GO:"canonical Wnt signaling pathway") - pmid:30116051 + pubmed:30232325 - a(CHEBI:"alpha,alpha-trehalose") decreases a(HBP:"huntingtin aggregates") + p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) increases bp(GO:"non-canonical Wnt signaling pathway") - pmid:30116051 + pubmed:30232325 - a(CHEBI:"alpha,alpha-trehalose") decreases a(HBP:"amyloid-beta aggregates") + p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) increases a(CHEBI:amyloid-beta) - pmid:30116051 + pubmed:11230871 - a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:"motor behavior") + p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) association act(p(HGNC:APP)) - pmid:30116051 + pubmed:11230871 - a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:cognition) + p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) increases path(MESH:"Plaque, Amyloid") - pmid:23528736 + pubmed:11230871 - a(CHEBI:"alpha,alpha-trehalose") decreases bp(GO:"neuron apoptotic process") + p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) negativeCorrelation p(FPLX:CHRN) - pmid:29626319 + pubmed:30232325 - a(CHEBI:"alpha,alpha-trehalose") decreases a(CHEBI:"amyloid-beta") + bp(GO:"amyloid-beta formation") negativeCorrelation bp(GO:"canonical Wnt signaling pathway") - pmid:29626319 + pubmed:30232325 - a(CHEBI:"alpha,alpha-trehalose") increases p(HGNC:BAG3) + bp(GO:"amyloid-beta formation") positiveCorrelation bp(GO:"Wnt signaling pathway, planar cell polarity pathway") - pmid:29758300 + pubmed:27209302 - a(CHEBI:paclitaxel) increases a(GO:microtubule) + bp(GO:"amyloid-beta formation") increases p(CONSO:"amyloid-beta fibrils", loc(MESH:Lysosomes)) - pmid:30116051 + pubmed:27209302 - a(CHEBI:paclitaxel) increases a(GO:microtubule) + bp(GO:"amyloid-beta formation") increases p(CONSO:"amyloid-beta fibrils", loc(GO:cytoplasm)) - pmid:29758300 + pubmed:30232325 - a(CHEBI:paclitaxel) increases tloc(a(GO:autophagosome), fromLoc(GO:"extracellular space"), toLoc(MESH:Neurons)) + act(p(HGNC:DKK1)) decreases act(p(HGNC:WNT3A)) - pmid:22941973 + pubmed:30232325 - a(CHEBI:paclitaxel) decreases p(RGD:Mapt, pmod(Ph, Ser, 262)) + act(p(HGNC:DKK1)) decreases bp(GO:"canonical Wnt signaling pathway") - pmid:22941973 + pubmed:30232325 - a(CHEBI:paclitaxel) increases p(RGD:Syp) + act(p(HGNC:DKK1)) increases act(p(HGNC:WNT5A)) - pmid:29758300 + pubmed:30232325 - a(CHEBI:epothilone) decreases path(MESH:Tauopathies) + act(p(HGNC:DKK1)) increases bp(GO:"Wnt signaling pathway, planar cell polarity pathway") - pmid:29758300 + pubmed:30232325 - a(CHEBI:epothilone) increases bp(GO:cognition) + p(HGNC:DKK1) increases path(CONSO:CONSO00061) - - - pmid:14556719 + pubmed:30232325 - composite(a(CHEBI:ATP), p(HGNC:UBA1)) increases act(a(MESH:Ubiquitin)) + p(HGNC:DKK1) decreases a(MESH:"Dendritic Spines") - pmid:22908190 + pubmed:30232325 - composite(a(CHEBI:ATP), p(HGNC:UBA1)) increases act(a(MESH:Ubiquitin)) + p(HGNC:DKK1) decreases a(MESH:"Dendritic Spines") - - - pmid:14556719 - - act(a(MESH:Ubiquitin)) increases complex(a(MESH:Ubiquitin), p(HGNC:UBA1)) - - - pmid:22908190 + pubmed:30232325 - a(MESH:Ubiquitin) association a(HBP:"paired helical filaments") + p(HGNC:DKK1) increases a(CHEBI:amyloid-beta) - pmid:22908190 + pubmed:30232325 - a(MESH:Ubiquitin) association a(GO:"neurofibrillary tangle") + p(HGNC:DKK1) increases bp(GO:"amyloid-beta formation") - pmid:22908190 + pubmed:18494933 - a(MESH:Ubiquitin) association a(HBP:"dystrophic neurite") + p(HGNC:DKK1) increases act(p(HGNC:GSK3B)) - pmid:22908190 + pubmed:18494933 - a(MESH:Ubiquitin) association path(HBP:"granulovacuolar degeneration") + p(HGNC:DKK1) increases act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) - pmid:22908190 + pubmed:18494933 - a(MESH:Ubiquitin) association path(HBP:"granulovacuolar degeneration") + p(HGNC:DKK1) decreases bp(GO:"Wnt signaling pathway") - pmid:22908190 + pubmed:18494933 - a(MESH:Ubiquitin) association a(MESH:"Neuropil Threads") + p(HGNC:DKK1) increases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation")) - pmid:22908190 + pubmed:18494933 - a(MESH:Ubiquitin) association a(GO:"Lewy body") + p(HGNC:DKK1) increases deg(p(MESH:"beta Catenin")) - pmid:22908190 + pubmed:18494933 - a(MESH:Ubiquitin) association a(GO:"Lewy body") + p(HGNC:DKK1) positiveCorrelation deg(p(HGNC:CTNNB1)) - pmid:22908190 + pubmed:30232325 - a(MESH:Ubiquitin) association a(GO:"Pick body") + composite(p(HGNC:APP), p(HGNC:DKK1)) decreases a(MESH:"Dendritic Spines") + + - pmid:22908190 + pubmed:24760868 - act(a(MESH:Ubiquitin)) increases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) + a(MESH:"Dendritic Spines") increases complex(a(MESH:"Dendritic Spines"), p(HGNC:MAPT)) - pmid:22908190 + pubmed:27796283 - a(MESH:Ubiquitin) increases tloc(a(MESH:Proteins), fromLoc(GO:cytoplasm), toLoc(GO:"multivesicular body")) + a(MESH:"Dendritic Spines") positiveCorrelation bp(GO:"dendritic spine development") - pmid:24457024 + pubmed:27796283 - a(MESH:Ubiquitin) regulates bp(GO:signaling) + a(MESH:"Dendritic Spines") negativeCorrelation act(p(HGNC:RHOA)) - pmid:24457024 + pubmed:27796283 - a(MESH:Ubiquitin) regulates bp(GO:endocytosis) + a(MESH:"Dendritic Spines") positiveCorrelation p(HGNC:CAMKV) - pmid:24457024 + pubmed:30232325 - a(MESH:Ubiquitin) regulates bp(GO:macroautophagy) + a(CHEBI:"fasudil hydrochloride") decreases bp(GO:"Wnt signaling pathway, planar cell polarity pathway") - pmid:24457024 + pubmed:30232325 - a(MESH:Ubiquitin) regulates bp(GO:"DNA repair") + a(CHEBI:"fasudil hydrochloride") decreases a(CHEBI:"amyloid-beta polypeptide 40") - pmid:24457024 + pubmed:30232325 - act(a(MESH:Ubiquitin)) regulates bp(GO:"cellular homeostasis") + a(CHEBI:"fasudil hydrochloride") decreases a(CHEBI:"amyloid-beta polypeptide 40") - - - pmid:24457024 + pubmed:30232325 - complex(a(MESH:Ubiquitin), p(HGNC:UBA1)) increases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) + composite(a(CHEBI:"fasudil hydrochloride"), p(HGNC:DKK1)) causesNoChange a(MESH:"Dendritic Spines") - pmid:24457024 + pubmed:30232325 - complex(a(MESH:Ubiquitin), p(HGNC:UBA1)) increases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) + composite(a(CHEBI:"fasudil hydrochloride"), p(HGNC:DKK1)) causesNoChange a(CHEBI:amyloid-beta) - pmid:14556719 + pubmed:10656250 - p(HGNC:UBA2) decreases complex(a(MESH:Ubiquitin), p(HGNC:UBA1)) + p(HGNC:BACE1, var("p.Asp25Asn")) causesNoChange tloc(p(CONSO:sAPP-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:14556719 + pubmed:10656250 - p(HGNC:UBA2) increases complex(a(MESH:Ubiquitin), p(HGNC:UBA3)) + p(HGNC:BACE1, var("p.Asp25Asn")) causesNoChange p(HGNC:APP, frag("672_770")) - pmid:14556719 + pubmed:10656250 - p(HGNC:UBA2) increases complex(a(MESH:Ubiquitin), p(INTERPRO:"HECT domain")) + p(HGNC:BACE1, var("p.Asp215Asn")) causesNoChange tloc(p(CONSO:sAPP-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:14556719 + pubmed:10656250 - act(p(HGNC:UBA2)) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:BACE1, var("p.Asp215Asn")) causesNoChange p(HGNC:APP, frag("672_770")) - pmid:14556719 + pubmed:10656250 - p(HGNC:UBA2) increases p(HGNC:HTT, pmod(Ub)) + p(HGNC:CTSD) causesNoChange tloc(p(CONSO:sAPP-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:24457024 + pubmed:19926167 - p(HGNC:UBA2) increases bp(GO:"protein ubiquitination") + p(HGNC:CTSD) association deg(p(HGNC:APP)) - - - - - pmid:24457024 + pubmed:19926167 - complex(a(MESH:Ubiquitin), p(HGNC:UBA3)) increases act(p(HGNC:UBA2)) + p(HGNC:CTSD) association p(HGNC:APP, frag("672_713")) - pmid:14556719 + pubmed:23516100 - p(HGNC:UBA3) increases bp(GO:"protein ubiquitination") + p(HGNC:CTSD) increases p(HGNC:APP, frag("35_*")) - pmid:14556719 + pubmed:23516100 - p(HGNC:UBA3) increases bp(GO:"protein ubiquitination") + p(HGNC:CTSD) increases p(HGNC:MAPT, frag("1_?")) - pmid:24457024 + pubmed:23516100 - p(HGNC:UBA3) increases bp(GO:"protein ubiquitination") + act(p(HGNC:CTSD)) association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:24457024 + pubmed:23516100 - p(HGNC:UBA3) increases bp(GO:"protein ubiquitination") + act(p(HGNC:CTSD)) increases p(HGNC:APP, frag("?")) - pmid:24457024 + pubmed:23516100 - p(HGNC:UBA3) increases bp(GO:"protein ubiquitination") + p(HGNC:CTSD) increases p(HGNC:APP, frag("1_35")) - pmid:14556719 + pubmed:23516100 - p(HGNC:UBA3) association bp(GO:proteolysis) + p(HGNC:CTSD) increases p(HGNC:SNCA, frag("1_?")) - pmid:22908190 + pubmed:23516100 - p(HGNC:UBA3) increases complex(a(MESH:Proteins), a(MESH:Ubiquitin), p(HGNC:UBA2), p(HGNC:UBA3)) + p(HGNC:CTSD) decreases p(HGNC:SNCA, loc(GO:lysosome)) - pmid:24457024 + pubmed:23516100 - p(HGNC:UBA3) increases act(p(HGNC:UBA2)) + p(HGNC:CTSD) decreases p(CONSO:"alpha-synuclein aggregates") - pmid:24457024 + pubmed:26968346 - p(HGNC:UBA3) regulates complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) + act(p(HGNC:CTSD)) increases p(HGNC:TFEB) - pmid:24457024 + pubmed:18930136 - p(HGNC:UBA3) regulates bp(GO:"protein polyubiquitination") + p(HGNC:CTSD) isA a(GO:autolysosome) - - - - - pmid:24457024 + pubmed:18930136 - p(INTERPRO:"HECT domain") increases complex(a(MESH:Ubiquitin), p(HGNC:UBA3)) + p(HGNC:CTSD) decreases path(CONSO:Neurodegeneration) - pmid:14556719 + pubmed:18930136 - p(INTERPRO:"E3 ubiquitin ligase RBR family") decreases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) + p(HGNC:CTSD) negativeCorrelation a(GO:lysosome) - pmid:14556719 + pubmed:18930136 - p(INTERPRO:"E3 ubiquitin ligase RBR family") increases complex(a(MESH:Proteins), a(MESH:Ubiquitin), p(HGNC:UBA3)) + p(HGNC:CTSD) negativeCorrelation a(GO:autophagosome) + + - pmid:24457024 + pubmed:24027553 - p(INTERPRO:"E3 ubiquitin ligase RBR family") increases complex(a(MESH:Ubiquitin), p(HGNC:UBA3)) + act(p(HGNC:CTSD)) increases p(HGNC:MAPT, frag("?", "29kD")) - - - - - pmid:24457024 + pubmed:24027553 - complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) increases act(p(HGNC:UBA2)) + act(p(HGNC:CTSD)) increases deg(p(HGNC:MAPT)) - - - - - - - pmid:14556719 + pubmed:24027553 - bp(GO:"protein ubiquitination") increases bp(GO:"lysosomal protein catabolic process") + act(p(HGNC:CTSD)) increases deg(p(HGNC:MAPT)) - pmid:14556719 + pubmed:23528736 - bp(GO:"protein ubiquitination") increases bp(GO:"protein catabolic process in the vacuole") + p(HGNC:CTSD) increases deg(p(HGNC:MAPT)) - pmid:14556719 + pubmed:29626319 - bp(GO:"protein ubiquitination") regulates bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + p(HGNC:CTSD) increases deg(p(HGNC:MAPT)) - pmid:18930136 + pubmed:24027553 - bp(GO:"protein ubiquitination") regulates bp(GO:autophagy) + act(p(HGNC:CTSD)) increases p(HGNC:MAPT, frag("?", "29kD"), pmod(go:0006468 ! "protein phosphorylation")) - pmid:14556719 + pubmed:24027553 - bp(GO:"protein K48-linked ubiquitination") increases act(complex(GO:"proteasome complex")) + act(p(HGNC:CTSD)) increases path(MESH:Neuroprotection) - pmid:14556719 + pubmed:24027553 - bp(GO:"protein K63-linked ubiquitination") increases act(complex(GO:"proteasome complex")) + act(p(HGNC:CTSD)) decreases path(CONSO:neurotoxicity) - pmid:22908190 + pubmed:10656250 - bp(GO:"protein K63-linked ubiquitination") association a(GO:"neurofibrillary tangle") + p(CONSO:APP751) association p(HGNC:BACE1) - pmid:18930136 + pubmed:22791904 - bp(GO:"protein K63-linked ubiquitination") increases act(p(HGNC:SQSTM1)) + a(PUBCHEM:11249342) increases path(MESH:Nausea) - pmid:18930136 + pubmed:22791904 - bp(GO:"protein K63-linked ubiquitination") increases act(p(HGNC:HDAC6)) + a(PUBCHEM:11249342) causesNoChange path(MESH:Nausea) - pmid:18930136 + pubmed:22791904 - bp(GO:"protein K63-linked ubiquitination") increases bp(GO:autophagy) + a(PUBCHEM:11249342) increases path(MESH:Vomiting) - pmid:14556719 + pubmed:22791904 - p(HGNC:MOCS3) increases bp(GO:"protein polyubiquitination") + a(PUBCHEM:11249342) causesNoChange path(MESH:Vomiting) - - - - - pmid:22908190 + pubmed:22791904 - p(HBP:"20 S Proteasome") increases deg(p(HGNC:MAPT)) + a(PUBCHEM:11249342) decreases p(CONSO:sAPP-alpha) - pmid:22908190 + pubmed:22791904 - p(HBP:"20 S Proteasome") increases complex(a(HBP:"Tau aggregates"), p(HBP:"20 S Proteasome")) + a(PUBCHEM:11249342) decreases p(CONSO:sAPP-beta) - pmid:16816118 + pubmed:22791904 - act(p(HBP:"20 S Proteasome")) increases deg(p(RGD:Mapt, pmod(HBP:hyperphosphorylation))) + a(PUBCHEM:11249342) decreases p(HGNC:MAPT) - pmid:16816118 + pubmed:22791904 - act(p(HBP:"20 S Proteasome")) increases deg(p(RGD:Mapt)) + a(PUBCHEM:11249342) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - - - - - pmid:14556719 + pubmed:22791904 - complex(GO:"proteasome regulatory particle") increases bp(GO:"protein unfolding") + a(PUBCHEM:11249342) decreases p(HGNC:C3) - pmid:14556719 + pubmed:22791904 - p(HGNC:PSMD4) increases complex(a(MESH:Ubiquitin), p(HGNC:PSMD4)) + a(PUBCHEM:11249342) decreases p(HGNC:CCL2) - pmid:14556719 + pubmed:22791904 - p(HGNC:PSMD4) association p(HGNC:PRKN) + a(PUBCHEM:11249342) decreases p(HGNC:CHI3L1) - pmid:24457024 + pubmed:22791904 - p(HGNC:PSMD4) increases complex(a(GO:"proteasome complex"), p(MESH:Proteins, pmod(Ub))) + a(PUBCHEM:11249342) causesNoChange p(HGNC:CFH) - pmid:25036637 + pubmed:30444369 - p(HGNC:PSMD4) directlyIncreases complex(p(HGNC:ADRM1), p(HGNC:PSMC1), p(HGNC:PSMD4)) + a(CHEBI:tacrine) increases bp(GO:cognition) - pmid:25036637 + pubmed:30444369 - p(HGNC:PSMD4) directlyIncreases complex(p(HGNC:PSMD4), p(HGNC:USP14)) + a(CHEBI:tacrine) decreases act(p(FPLX:Cholinesterase)) - pmid:25036637 + pubmed:19293145 - p(HGNC:PSMD4) directlyIncreases complex(p(HGNC:PSMC1), p(HGNC:PSMD4)) + a(CHEBI:tacrine) increases p(HGNC:BCL2) - pmid:25036637 + pubmed:19293145 - p(HGNC:PSMD4) directlyIncreases complex(p(HGNC:PSMD2), p(HGNC:PSMD4)) + act(a(CHEBI:tacrine)) negativeCorrelation g(HGNC:APOE) - pmid:25036637 + pubmed:24511233 - p(HGNC:PSMD4) directlyIncreases complex(p(HGNC:PRPS2), p(HGNC:PSMD4)) + a(CHEBI:tacrine) isA a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") - pmid:25036637 + pubmed:11230871 - p(HGNC:PSMD4) directlyIncreases complex(p(HGNC:PSMA5), p(HGNC:PSMD4)) + a(CHEBI:tacrine) decreases act(p(HGNC:ACHE)) - pmid:14556719 + pubmed:11230871 - p(HGNC:PSMC3) increases complex(a(MESH:Ubiquitin), p(HGNC:PSMC3)) + a(CHEBI:tacrine) increases act(p(HGNC:ACHE)) - - - - - - - - - - - - - pmid:14556719 + pubmed:11230871 - deg(complex(a(MESH:Proteins), a(MESH:Ubiquitin))) increases a(MESH:Ubiquitin) + a(CHEBI:tacrine) increases act(p(FPLX:CHRN)) - pmid:14556719 + pubmed:11230871 - deg(complex(a(MESH:Proteins), a(MESH:Ubiquitin))) increases a(CHEBI:peptide) + a(CHEBI:tacrine) increases p(FPLX:CHRN) - - - - - pmid:14556719 + pubmed:11230871 - complex(a(MESH:"Molecular Chaperones"), a(MESH:Proteins)) increases bp(GO:"protein stabilization") + a(CHEBI:tacrine) increases p(FPLX:CHRN) - pmid:14556719 + pubmed:30444369 - bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"cell cycle") + a(CHEBI:donepezil) increases bp(GO:cognition) - pmid:14556719 + pubmed:26813123 - bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"cell division") + a(CHEBI:donepezil) increases bp(GO:cognition) - pmid:14556719 + pubmed:30444369 - bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"cell differentiation") + a(CHEBI:donepezil) decreases act(p(FPLX:Cholinesterase)) - pmid:14556719 + pubmed:19126755 - bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(MESH:"Cell Proliferation") + a(CHEBI:donepezil) decreases p(HGNC:ACHE) - pmid:14556719 + pubmed:11230871 - bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"cellular response to stress") + a(CHEBI:donepezil) decreases act(p(HGNC:ACHE)) - pmid:14556719 + pubmed:19293145 - bp(GO:"ubiquitin-dependent protein catabolic process") regulates a(MESH:"Receptors, Cell Surface") + a(CHEBI:donepezil) isA a(CHEBI:"EC 3.1.1.8 (cholinesterase) inhibitor") - pmid:14556719 + pubmed:19293145 - bp(GO:"ubiquitin-dependent protein catabolic process") regulates a(MESH:"Ion Channels") + a(CHEBI:donepezil) decreases path(MESH:"Alzheimer Disease") - pmid:14556719 + pubmed:19293145 - bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(MESH:"Secretory Pathway") + a(CHEBI:donepezil) decreases path(CONSO:neurotoxicity) - pmid:14556719 + pubmed:19293145 - bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"DNA repair") + a(CHEBI:donepezil) decreases path(CONSO:neurotoxicity) - pmid:14556719 + pubmed:19293145 - bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"gene silencing") + a(CHEBI:donepezil) regulates act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:14556719 + pubmed:19293145 - bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"long-term memory") + a(CHEBI:donepezil) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:14556719 + pubmed:19293145 - bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"circadian rhythm") + a(CHEBI:donepezil) increases p(HGNC:CHRNA4) - pmid:14556719 + pubmed:19293145 - bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"immune response") + a(CHEBI:donepezil) increases p(HGNC:CHRNA7) - pmid:14556719 + pubmed:19293145 - bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"inflammatory response") + a(CHEBI:donepezil) increases bp(MESH:Neuroprotection) - pmid:14556719 + pubmed:19293145 - bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"organelle organization") + a(CHEBI:donepezil) increases p(HGNC:BCL2) - pmid:27181519 + pubmed:24511233 - bp(GO:"DNA repair") association p(HGNC:FUS) + a(CHEBI:donepezil) isA a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") - pmid:25036637 + pubmed:18986241 - bp(GO:"gene silencing") association p(HGNC:DCP1A) + a(CHEBI:donepezil) increases act(a(MESH:"Frontal Lobe")) - pmid:25036637 + pubmed:11230871 - bp(GO:"gene silencing") association p(HGNC:EDC3) + a(CHEBI:donepezil) increases act(p(FPLX:CHRN)) - pmid:25036637 + pubmed:11230871 - bp(GO:"gene silencing") association p(HGNC:DDX6) + a(CHEBI:donepezil) increases p(FPLX:CHRN) - pmid:14556719 + pubmed:29626319 - path(MESH:Cachexia) increases bp(GO:"protein catabolic process") + a(CHEBI:donepezil) increases p(HGNC:ABCB1) - pmid:14556719 + pubmed:29626319 - path(MESH:Sepsis) increases bp(GO:"protein catabolic process") + a(CHEBI:donepezil) increases p(HGNC:LRP1) - pmid:14556719 + pubmed:29626319 - path(MESH:Acidosis) increases bp(GO:"protein catabolic process") + a(CHEBI:donepezil) decreases a(CHEBI:amyloid-beta) - pmid:14556719 + pubmed:30444369 - a(MESH:Denervation) increases bp(GO:"protein catabolic process") + a(CHEBI:rivastigmine) increases bp(GO:cognition) - pmid:14556719 + pubmed:30444369 - p(HGNC:NEDD8) increases complex(a(GO:"SCF ubiquitin ligase complex"), p(HGNC:UBA2)) + a(CHEBI:rivastigmine) decreases act(p(FPLX:Cholinesterase)) - - - - - pmid:14556719 + pubmed:19126755 - p(HGNC:SUMO1) increases p(HGNC:NFKBIA, pmod(Sumo)) + a(CHEBI:rivastigmine) decreases p(HGNC:ACHE) - pmid:27716675 + pubmed:11230871 - p(HGNC:SUMO1) positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:rivastigmine) decreases act(p(HGNC:ACHE)) - pmid:23229893 + pubmed:19293145 - p(HGNC:SUMO1) association a(GO:lysosome) + a(CHEBI:rivastigmine) isA a(CHEBI:"EC 3.1.1.8 (cholinesterase) inhibitor") - pmid:19323834 + pubmed:19293145 - p(HGNC:SUMO1) partOf complex(p(FPLX:CEBP), p(HGNC:SUMO1)) + a(CHEBI:rivastigmine) decreases path(MESH:"Alzheimer Disease") - pmid:18675254 + pubmed:26813123 - p(HGNC:SUMO1) increases p(HGNC:APP, pmod(Sumo, Lys, 587)) + a(CHEBI:rivastigmine) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:18675254 + pubmed:19293145 - p(HGNC:SUMO1) increases p(HGNC:APP, pmod(Sumo, Lys, 595)) + a(CHEBI:rivastigmine) decreases path(CONSO:neurotoxicity) - pmid:16464864 + pubmed:19293145 - p(HGNC:SUMO1) increases p(HGNC:MAPT, pmod(Sumo, Lys, 340)) + a(CHEBI:rivastigmine) regulates act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:16464864 + pubmed:24511233 - p(HGNC:SUMO1) increases p(HGNC:SNCA, pmod(Sumo)) + a(CHEBI:rivastigmine) isA a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") - pmid:14556719 + pubmed:11230871 - p(HGNC:NFKBIA, pmod(Sumo)) decreases bp(GO:"protein ubiquitination") + a(CHEBI:rivastigmine) increases act(p(FPLX:CHRN)) - pmid:14556719 + pubmed:11230871 - p(UNIPROT:P32628) increases tloc(p(MESH:Proteins, pmod(Ub)), fromLoc(GO:cytosol), toLoc(GO:"proteasome complex")) + a(CHEBI:rivastigmine) increases p(FPLX:CHRN) - pmid:22908190 + pubmed:29687724 - p(MESH:Proteins, pmod(Ub)) increases deg(p(MESH:Proteins, pmod(Ub))) + a(CHEBI:rivastigmine) increases bp(GO:"motor behavior") - pmid:22908190 + pubmed:29687724 - p(MESH:Proteins, pmod(Ub)) increases complex(a(GO:"proteasome regulatory particle"), p(MESH:Proteins, pmod(Ub))) + a(CHEBI:rivastigmine) increases path(MESH:Cognition) - pmid:27181519 + pubmed:29626319 - p(MESH:Proteins, pmod(Ub)) negativeCorrelation bp(GO:"stress granule assembly") + a(CHEBI:rivastigmine) increases p(HGNC:ABCB1) - pmid:14556719 + pubmed:29626319 - p(UNIPROT:P48510) increases tloc(p(MESH:Proteins, pmod(Ub)), fromLoc(GO:cytosol), toLoc(GO:"proteasome complex")) + a(CHEBI:rivastigmine) increases p(HGNC:LRP1) - - - - - pmid:14556719 + pubmed:29626319 - complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation a(MESH:"Neurofibrillary Tangles") + a(CHEBI:rivastigmine) decreases a(CHEBI:amyloid-beta) - pmid:14556719 + pubmed:30444369 - complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation a(GO:"Bunina body") + a(CHEBI:memantine) increases bp(GO:cognition) - pmid:14556719 + pubmed:30444369 - complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation path(MESH:"Huntington Disease") + a(CHEBI:memantine) decreases act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) - pmid:14556719 + pubmed:19293145 - complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation path(MESH:"Spinocerebellar Ataxias") + a(CHEBI:memantine) isA a(CHEBI:"NMDA receptor antagonist") - pmid:14556719 + pubmed:22530628 - complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation path(MESH:"Bulbo-Spinal Atrophy, X-Linked") + a(CHEBI:memantine) isA a(CHEBI:"NMDA receptor antagonist") - pmid:14556719 + pubmed:19293145 - complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation a(MESH:"Lewy Bodies") + a(CHEBI:memantine) decreases path(MESH:"Alzheimer Disease") - pmid:14556719 + pubmed:23722080 - a(MESH:"Inclusion Bodies") negativeCorrelation path(MESH:"Parkinsonian Disorders") + a(CHEBI:memantine) decreases path(MESH:"Alzheimer Disease") - pmid:14556719 + pubmed:22530628 - a(MESH:"Inclusion Bodies") association p(HGNC:SNCA) + a(CHEBI:memantine) decreases path(DOID:"Alzheimer's disease") - pmid:14556719 + pubmed:26813123 - a(MESH:"Inclusion Bodies") association p(HGNC:CREBBP) + a(CHEBI:memantine) decreases path(CONSO:Excitotoxicity) - + + + pubmed:16273023 + + a(CHEBI:memantine) decreases complex(a(CHEBI:"calcium(2+)"), p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) + - pmid:14556719 + pubmed:16273023 - complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation a(MESH:"Neurofibrillary Tangles") + a(CHEBI:memantine) causesNoChange bp(MESH:D009435) - pmid:14556719 + pubmed:23722080 - complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation a(GO:"Bunina body") + a(CHEBI:memantine) decreases p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation")) - pmid:14556719 + pubmed:23722080 - complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation path(MESH:"Huntington Disease") + a(CHEBI:memantine) increases bp(GO:"cellular metabolic process") - pmid:14556719 + pubmed:30837838 - complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation path(MESH:"Spinocerebellar Ataxias") + a(CHEBI:memantine) decreases a(CHEBI:"D-glutamate(1-)") - pmid:14556719 + pubmed:30837838 - complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation path(MESH:"Bulbo-Spinal Atrophy, X-Linked") + a(CHEBI:memantine) decreases path(MESH:"Amyotrophic Lateral Sclerosis") - pmid:14556719 + pubmed:30444369 - complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation a(MESH:"Lewy Bodies") + g(HGNC:APP, var("?")) increases path(MESH:"Alzheimer Disease") - pmid:14556719 + pubmed:29196815 - path(MESH:"Spinocerebellar Ataxias") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) + g(HGNC:APP, var("?")) increases path(MESH:"Alzheimer Disease") - pmid:14556719 + pubmed:26195256 - path(MESH:"Spinocerebellar Ataxias") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) + g(HGNC:APP, var("?")) association path(MESH:"Alzheimer Disease") - pmid:14556719 + pubmed:30444369 - a(MESH:"Lewy Bodies") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) + g(HGNC:APP, var("?")) increases bp(GO:"amyloid-beta formation") - pmid:14556719 + pubmed:30116051 - a(MESH:"Lewy Bodies") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) + g(HGNC:APP, var("?")) decreases act(a(GO:endosome)) - pmid:14556719 + pubmed:30116051 - a(MESH:"Lewy Bodies") association a(GO:"dopaminergic synapse") + g(HGNC:APP, var("?")) decreases act(a(GO:lysosome)) - pmid:14556719 + pubmed:30116051 - a(MESH:"Lewy Bodies") negativeCorrelation path(MESH:"Parkinsonian Disorders") + g(HGNC:APP, var("?")) increases p(CONSO:C99) + + - pmid:14556719 + pubmed:30444369 - a(MESH:"Lewy Bodies") negativeCorrelation path(MESH:"Parkinsonian Disorders") + g(CONSO:"APOE e4") increases path(MESH:"Alzheimer Disease") - pmid:14556719 + pubmed:29758300 - a(MESH:"Lewy Bodies") association a(HBP:"alpha-synuclein aggregates") + g(CONSO:"APOE e4") increases path(MESH:"Alzheimer Disease") - pmid:14556719 + pubmed:22908190 - a(MESH:"Lewy Bodies") association path(MESH:"Parkinson Disease") + g(CONSO:"APOE e4") association path(MESH:"Alzheimer Disease") - pmid:14556719 + pubmed:30116051 - a(GO:"dopaminergic synapse") association a(MESH:"Lewy Bodies") + g(CONSO:"APOE e4") increases path(MESH:"Alzheimer Disease") - pmid:14556719 + pubmed:26195256 - p(HGNC:PRKN) positiveCorrelation path(MESH:"Parkinson Disease") + g(CONSO:"APOE e4") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27181519 + pubmed:30444369 - p(HGNC:PRKN) association path(MESH:"Parkinson Disease") + g(CONSO:"APOE e4") increases bp(GO:"amyloid-beta clearance") - - - pmid:14556719 + pubmed:19293145 - p(HGNC:PRKN) association p(HGNC:PSMD4) + g(CONSO:"APOE e4") decreases act(a(CHEBI:carbachol)) @@ -114665,715 +115888,759 @@

Statements

- pmid:14556719 + pubmed:29758300 - p(HGNC:PRKN) association bp(MESH:"Synaptic Transmission") + g(CONSO:"APOE e4") increases bp(GO:"cholesterol metabolic process") - pmid:14556719 + pubmed:29758300 - p(HGNC:PRKN) negativeCorrelation a(MESH:"Dopaminergic Neurons") + g(CONSO:"APOE e4") regulates deg(a(CHEBI:amyloid-beta)) - pmid:14556719 + pubmed:22908190 - p(HGNC:PRKN) increases p(HGNC:SEPT5, pmod(Ub)) + g(CONSO:"APOE e4") increases act(a(CHEBI:amyloid-beta)) - pmid:14556719 + pubmed:26195256 - p(HGNC:PRKN) association p(HGNC:GPR37) + g(CONSO:"APOE e4") positiveCorrelation a(CHEBI:amyloid-beta) - pmid:14556719 + pubmed:22908190 - p(HGNC:PRKN) decreases bp(GO:"response to unfolded protein") + g(CONSO:"APOE e4") regulates bp(GO:"cholesterol transport") - pmid:14556719 + pubmed:22908190 - p(HGNC:PRKN) decreases act(p(HGNC:SNCA)) + g(CONSO:"APOE e4") positiveCorrelation p(CONSO:"APP C-terminally truncated carboxyl-terminal fragments") - pmid:14556719 + pubmed:22908190 - p(HGNC:PRKN) regulates p(HGNC:SNCA) + g(CONSO:"APOE e4") positiveCorrelation p(CONSO:"APP C-terminally truncated carboxyl-terminal fragments") - pmid:14556719 + pubmed:22908190 - p(HGNC:PRKN) association p(HGNC:SNCA, pmod(OGlyco)) + g(CONSO:"APOE e4") positiveCorrelation p(CONSO:"APP C-terminally truncated carboxyl-terminal fragments") - pmid:14556719 + pubmed:22908190 - p(HGNC:PRKN) increases p(HGNC:SNCAIP, pmod(Ub)) + g(CONSO:"APOE e4") positiveCorrelation bp(GO:endocytosis) - pmid:14556719 + pubmed:22908190 - p(HGNC:PRKN) increases p(HGNC:SNCAIP, pmod(Ub)) + g(CONSO:"APOE e4") increases a(GO:endosome) - pmid:14556719 + pubmed:22908190 - p(HGNC:PRKN) increases tloc(p(HGNC:SNCAIP, pmod(Ub)), fromLoc(GO:cytosol), toLoc(MESH:"Inclusion Bodies")) + g(CONSO:"APOE e4") positiveCorrelation tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:cytosol), toLoc(GO:lysosome)) - pmid:14556719 + pubmed:30116051 - p(HGNC:PRKN) increases act(complex(GO:"proteasome complex")) + g(CONSO:"APOE e4") increases a(CHEBI:"amyloid-beta polypeptide 42") - pmid:14556719 + pubmed:22908190 - p(HGNC:PRKN) decreases act(p(HGNC:CASP12)) + g(CONSO:"APOE e4") increases path(CONSO:Neurodegeneration) - pmid:14556719 + pubmed:22908190 - p(HGNC:PRKN) association p(HGNC:CCNE1) + g(CONSO:"APOE e4") increases bp(GO:"apoptotic process") - pmid:14556719 + pubmed:30116051 - p(HGNC:PRKN) decreases p(HGNC:CCNE1) + g(CONSO:"APOE e4") increases p(HGNC:LGMN) - pmid:14556719 + pubmed:26195256 - p(HGNC:PRKN) decreases bp(GO:"neuron apoptotic process") + g(CONSO:"APOE e4") regulates bp(GO:"establishment of blood-brain barrier") - pmid:14556719 + pubmed:26195256 - p(HGNC:PRKN) decreases bp(GO:"cell death") + g(CONSO:"APOE e4") increases act(p(HGNC:PPIA)) - - - pmid:14556719 + pubmed:27087442 - p(HGNC:PRKN) increases p(HGNC:SYT11, pmod(Ub)) + g(CONSO:"APOE e4") increases p(MGI:Cdk5) - pmid:14556719 + pubmed:27087442 - p(HGNC:PRKN) association a(GO:"actin filament") + g(CONSO:"APOE e4") increases p(CONSO:"CDK5R1 p25") - pmid:14556719 + pubmed:27087442 - p(HGNC:PRKN) regulates act(a(MESH:Actins)) + g(CONSO:"APOE e4") increases p(MGI:Cdk5r1) - pmid:14556719 + pubmed:27087442 - p(HGNC:PRKN) association p(HGNC:SNCA, pmod(Glyco)) + g(CONSO:"APOE e4") increases p(MGI:Capn1) - pmid:22908190 + pubmed:27087442 - p(HGNC:PRKN) positiveCorrelation path(MESH:"Alzheimer Disease") + g(CONSO:"APOE e4") increases p(MGI:Capn2) - pmid:23528736 + pubmed:27087442 - p(HGNC:PRKN) association path(MESH:"Alzheimer Disease") + g(CONSO:"APOE e4") causesNoChange p(MGI:Gsk3b) - pmid:22908190 + pubmed:28720530 - p(HGNC:PRKN) increases bp(GO:mitophagy) + g(CONSO:"APOE e4") decreases p(HGNC:PPP2R5E) - pmid:22908190 + pubmed:28720530 - p(HGNC:PRKN) increases bp(GO:"proteasomal protein catabolic process") + g(CONSO:"APOE e4") decreases act(p(FPLX:PPP2)) - pmid:23528736 + pubmed:30444369 - p(HGNC:PRKN) association path(MESH:"Neurodegenerative Diseases") + g(HGNC:PSEN1, var("?")) increases path(MESH:"Alzheimer Disease") - pmid:27181519 + pubmed:29196815 - p(HGNC:PRKN) increases complex(a(GO:mitochondrion), p(HGNC:OPTN)) + g(HGNC:PSEN1, var("?")) increases path(MESH:"Alzheimer Disease") - pmid:14556719 + pubmed:30116051 - p(HGNC:PRKN, var("?")) increases path(MESH:"Parkinsonian Disorders") + g(HGNC:PSEN1, var("?")) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:14556719 + pubmed:26195256 - p(HGNC:PRKN, var("?")) decreases act(p(HGNC:PRKN)) + g(HGNC:PSEN1, var("?")) association path(MESH:"Alzheimer Disease") - pmid:14556719 + pubmed:30116051 - p(HGNC:PRKN, var("?")) increases p(HGNC:PRKN) + g(HGNC:PSEN1, var("?")) negativeCorrelation act(complex(GO:"lysosomal proton-transporting V-type ATPase complex")) - pmid:14556719 + pubmed:30116051 - p(HGNC:PRKN, var("?")) decreases act(p(HGNC:SEPT5)) + g(HGNC:PSEN1, var("?")) negativeCorrelation bp(GO:autophagy) - pmid:14556719 + pubmed:30116051 - p(HGNC:PRKN, var("?")) causesNoChange deg(p(HGNC:SNCA)) + g(HGNC:PSEN1, var("?")) negativeCorrelation bp(GO:mitophagy) - pmid:28803412 + pubmed:30444369 - p(HGNC:PRKN, var("?")) increases path(MESH:"Neurodegenerative Diseases") + g(HGNC:PSEN2, var("?")) increases path(MESH:"Alzheimer Disease") - pmid:30116051 + pubmed:29196815 - p(HGNC:PRKN, var("?")) association path(MESH:"Parkinson Disease") + g(HGNC:PSEN2, var("?")) increases path(MESH:"Alzheimer Disease") - pmid:30116051 + pubmed:26195256 - p(HGNC:PRKN, var("?")) decreases bp(GO:mitophagy) + g(HGNC:PSEN2, var("?")) association path(MESH:"Alzheimer Disease") + + + + + + + + - pmid:30116051 + pubmed:22908190 - p(HGNC:PRKN, var("?")) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + p(CONSO:"APP C-terminally truncated carboxyl-terminal fragments") increases act(p(HGNC:RAB5A)) - pmid:14556719 + pubmed:22908190 - path(MESH:"Parkinsonian Disorders") negativeCorrelation a(MESH:"Lewy Bodies") + p(CONSO:"APP C-terminally truncated carboxyl-terminal fragments") increases act(p(HGNC:RAB5A)) - pmid:14556719 + pubmed:22908190 - path(MESH:"Parkinsonian Disorders") negativeCorrelation a(MESH:"Lewy Bodies") + p(CONSO:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation g(CONSO:"APOE e4") - pmid:14556719 + pubmed:22908190 - path(MESH:"Parkinsonian Disorders") positiveCorrelation p(HGNC:GPR37) + p(CONSO:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation g(CONSO:"APOE e4") - pmid:14556719 + pubmed:22908190 - path(MESH:"Parkinsonian Disorders") association p(HGNC:SNCA, var("?")) + p(CONSO:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation g(CONSO:"APOE e4") - pmid:14556719 + pubmed:22908190 - path(MESH:"Parkinsonian Disorders") negativeCorrelation a(MESH:"Inclusion Bodies") + p(CONSO:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation a(CHEBI:"low-density lipoprotein cholesterol") - pmid:14556719 + pubmed:22908190 - path(MESH:"Parkinsonian Disorders") association p(HGNC:PRKN, var("p.Lys161Asn")) + p(CONSO:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation a(CHEBI:"low-density lipoprotein cholesterol") - pmid:14556719 + pubmed:22908190 - path(MESH:"Parkinsonian Disorders") positiveCorrelation a(HBP:"alpha-synuclein aggregates") + p(CONSO:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation p(HGNC:APP) - pmid:14556719 + pubmed:22908190 - path(MESH:"Parkinsonian Disorders") increases path(HBP:Neurodegeneration) + p(CONSO:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation a(CHEBI:cholesterol) - pmid:14556719 + pubmed:22908190 - path(MESH:"Parkinsonian Disorders") association g(HGNC:PARK7, var("?")) + p(CONSO:"APP C-terminally truncated carboxyl-terminal fragments") positiveCorrelation bp(GO:endocytosis) - pmid:14556719 + pubmed:30444369 - path(MESH:"Parkinsonian Disorders") association p(HGNC:PARK7, var("p.Leu166Pro")) + complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases path(MESH:"Alzheimer Disease") - pmid:30126037 + pubmed:30444369 - path(MESH:"Parkinsonian Disorders") association path(MESH:"Supranuclear Palsy, Progressive") + complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases bp(GO:"response to oxidative stress") - pmid:14556719 + pubmed:30444369 - p(HGNC:PRKN, var("p.Arg42")) decreases complex(a(GO:"proteasome complex"), p(HGNC:PRKN)) + complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases a(CHEBI:"reactive oxygen species") - pmid:14556719 + pubmed:30444369 - p(HGNC:PRKN, var("p.Arg42")) increases path(MESH:"Parkinsonian Disorders") + complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases a(CHEBI:"reactive oxygen species") - - - - - pmid:14556719 + pubmed:30444369 - complex(a(GO:"proteasome complex"), p(HGNC:PRKN)) decreases path(MESH:"Parkinsonian Disorders") + complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases bp(GO:"apoptotic DNA fragmentation") - - - + + + pubmed:30444369 + + complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases bp(GO:"neuron death") + - pmid:14556719 + pubmed:30444369 - complex(GO:"SCF ubiquitin ligase complex") increases p(HGNC:CCNE1, pmod(Ub)) + complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases bp(GO:learning) - pmid:29121589 + pubmed:30444369 - p(HGNC:CUL1) partOf complex(p(HGNC:BTRC), p(HGNC:CUL1), p(HGNC:NFE2L2, pmod(Ph))) + complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases act(p(FPLX:COX)) - pmid:14556719 + pubmed:30444369 - p(INTERPRO:"IBR domain", var("?")) decreases act(p(HGNC:PRKN)) + complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases bp(GO:"regulation of mitochondrial membrane potential") - + + + pubmed:30444369 + + complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases a(CHEBI:ATP) + - pmid:14556719 + pubmed:30444369 - complex(p(HGNC:PRKN), p(HGNC:STUB1)) increases act(p(HGNC:PRKN)) + complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases tloc(a(PUBCHEM:16057918), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - + + + pubmed:30444369 + + complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases act(p(HGNC:CASP3)) + - pmid:14556719 + pubmed:30444369 - p(HGNC:SEPT5) decreases sec(a(CHEBI:"growth hormone")) + complex(p(HGNC:APP), p(HGNC:HSD17B10)) increases bp(GO:"apoptotic process") - pmid:14556719 + pubmed:30444369 - p(HGNC:SEPT5) regulates sec(a(CHEBI:neurotransmitter)) + complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases complex(a(CHEBI:"NAD(+)"), p(HGNC:HSD17B10)) - pmid:14556719 + pubmed:30444369 - p(HGNC:SEPT5) regulates act(a(GO:"synaptic vesicle")) + complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases act(p(HGNC:HSD17B10)) - - - pmid:14556719 + pubmed:30444369 - complex(p(HGNC:SEPT5), p(HGNC:STX1A)) decreases bp(GO:exocytosis) + p(HGNC:HSD17B10) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:29191965 + pubmed:30444369 - a(GO:"synaptic vesicle") association complex(p(HGNC:KLC3), p(HGNC:MAPT)) + act(p(HGNC:HSD17B10)) increases rxn(reactants(a(PUBCHEM:440326)), products(a(PUBCHEM:193425))) - pmid:14556719 + pubmed:30444369 - p(HGNC:GPR37) association p(HGNC:PRKN) + act(p(HGNC:HSD17B10)) increases rxn(reactants(a(CHEBI:"NAD(+)"), a(PUBCHEM:9543037)), products(a(CHEBI:"3-oxo-fatty acyl-CoA(4-)"), a(CHEBI:NADH), a(PUBCHEM:1038))) - - - pmid:14556719 + pubmed:30444369 - p(HGNC:GPR37) increases p(HGNC:GPR37, pmod(HBP:misfolding)) + act(p(HGNC:HSD17B10)) increases rxn(reactants(a(PUBCHEM:15818)), products(a(PUBCHEM:10635))) - pmid:14556719 + pubmed:30444369 - p(HGNC:GPR37) positiveCorrelation bp(GO:"cell death") + act(p(HGNC:HSD17B10)) increases rxn(reactants(a(PUBCHEM:5757)), products(a(PUBCHEM:5870))) - pmid:14556719 + pubmed:30444369 - p(HGNC:GPR37) positiveCorrelation path(MESH:"Parkinsonian Disorders") + act(p(HGNC:HSD17B10)) association p(HGNCGENEFAMILY:"Gamma-aminobutyric acid type A receptor subunits") + + + + + + + + + + + + + + + + + + - pmid:14556719 + pubmed:30116051 - bp(GO:"response to unfolded protein") increases bp(GO:"cell death") + a(CHEBI:"NAD(+)") increases act(p(HGNC:SIRT1)) - pmid:14556719 + pubmed:30116051 - bp(GO:"response to unfolded protein") increases bp(GO:"response to endoplasmic reticulum stress") + a(CHEBI:"NAD(+)") increases act(p(HGNC:SIRT1)) + + + + + + + + + + - pmid:14556719 + pubmed:30444369 - bp(GO:"response to unfolded protein") increases a(MESH:"Molecular Chaperones") + a(PUBCHEM:5757) decreases a(CONSO:"amyloid-beta aggregates") - pmid:14556719 + pubmed:30444369 - bp(GO:"response to unfolded protein") positiveCorrelation bp(MESH:"Osmolar Concentration") + a(PUBCHEM:5757) decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:23746257 + pubmed:30444369 - bp(GO:"response to unfolded protein") regulates bp(HBP:Proteostasis) + a(PUBCHEM:5757) decreases act(p(HGNC:GSK3B)) - pmid:24563850 + pubmed:30444369 - bp(GO:"response to endoplasmic reticulum stress") increases act(p(HGNC:HSPA5)) + a(PUBCHEM:5757) increases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation")) - pmid:24563850 + pubmed:30444369 - bp(GO:"response to endoplasmic reticulum stress") decreases bp(HBP:misfolding) + a(PUBCHEM:5757) increases p(HGNC:BCL2) - pmid:24563850 + pubmed:30444369 - bp(GO:"response to endoplasmic reticulum stress") decreases bp(GO:"cell death") + a(PUBCHEM:5757) increases p(HGNC:BCL2L1) - pmid:24563850 + pubmed:30444369 - bp(GO:"response to endoplasmic reticulum stress") increases bp(GO:"cell death") + a(PUBCHEM:5757) decreases p(HGNC:BCL2L11) - pmid:24563850 + pubmed:30444369 - bp(GO:"response to endoplasmic reticulum stress") increases bp(GO:"apoptotic process") + a(PUBCHEM:5757) increases p(HGNC:SOD2) - pmid:26142647 + pubmed:30444369 - bp(GO:"response to endoplasmic reticulum stress") increases p(HGNC:PPP1R15A) + a(PUBCHEM:5757) increases p(FPLX:GPX) - pmid:23702978 + pubmed:30444369 - bp(GO:"response to endoplasmic reticulum stress") increases act(complex(GO:"NLRP3 inflammasome complex")) + p(HGNCGENEFAMILY:"Gamma-aminobutyric acid type A receptor subunits") association act(p(HGNC:HSD17B10)) - pmid:14556719 + pubmed:30444369 - p(MESH:Proteins, var("?")) increases bp(GO:"response to unfolded protein") + act(p(HGNCGENEFAMILY:"Gamma-aminobutyric acid type A receptor subunits")) positiveCorrelation a(PUBCHEM:101790) - + + + pubmed:30444369 + + act(p(HGNCGENEFAMILY:"Gamma-aminobutyric acid type A receptor subunits")) positiveCorrelation a(PUBCHEM:92786) + @@ -115381,432 +116648,432 @@

Statements

- pmid:14556719 + pubmed:30444369 - composite(p(HGNC:PRKN), p(HGNC:UBE2G1), p(HGNC:UBE2J1)) increases deg(p(HGNC:GPR37)) + a(PUBCHEM:101790) positiveCorrelation act(p(HGNCGENEFAMILY:"Gamma-aminobutyric acid type A receptor subunits")) - pmid:14556719 + pubmed:30444369 - a(CHEBI:"alkylating agent") increases bp(GO:"response to unfolded protein") + a(PUBCHEM:92786) positiveCorrelation act(p(HGNCGENEFAMILY:"Gamma-aminobutyric acid type A receptor subunits")) - pmid:14556719 + pubmed:30606258 - bp(MESH:"Ultraviolet Rays") increases bp(GO:"response to unfolded protein") + p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation")) decreases act(p(HGNC:GSK3B)) - pmid:14556719 + pubmed:18494933 - bp(MESH:"Osmolar Concentration") positiveCorrelation bp(GO:"response to unfolded protein") + p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation")) decreases act(p(HGNC:GSK3B)) - pmid:14556719 + pubmed:30444369 - p(HGNC:SNCA, pmod(OGlyco)) association p(HGNC:PRKN) + a(CHEBI:"methylene blue") decreases complex(p(HGNC:APP), p(HGNC:HSD17B10)) - - - pmid:14556719 + pubmed:30444369 - p(HGNC:SNCAIP) association p(HGNC:SNCA) + a(CHEBI:"methylene blue") decreases path(CONSO:"mitochondrial dysfunction") - - - - - pmid:14556719 + pubmed:30444369 - composite(p(HGNC:SNCA), p(HGNC:SNCAIP)) increases a(MESH:"Inclusion Bodies") + a(CHEBI:"methylene blue") decreases p(HGNC:HSD17B10) - pmid:14556719 + pubmed:30444369 - p(HGNC:ATXN3, frag("?")) decreases act(complex(GO:"proteasome complex")) + a(CHEBI:"methylene blue") decreases a(CONSO:"amyloid-beta aggregates") - pmid:14556719 + pubmed:29758300 - p(HGNC:ATXN3, frag("?")) increases act(p(HGNC:CASP12)) + a(CHEBI:"methylene blue") decreases p(HGNC:MAPT, pmod(CONSO:misfolding)) - - - - - - - pmid:14556719 + pubmed:29758300 - p(HGNC:CCNE1) association p(HGNC:PRKN) + a(CHEBI:"methylene blue") increases bp(GO:macroautophagy) - pmid:14556719 + pubmed:30116051 - p(HGNC:CCNE1) positiveCorrelation bp(GO:"neuron apoptotic process") + a(CHEBI:"methylene blue") increases bp(GO:macroautophagy) - + + + pubmed:29758300 + + a(CHEBI:"methylene blue") increases p(HGNC:BECN1) + - pmid:14556719 + pubmed:30116051 - composite(a(PUBCHEM:164810), p(HGNC:PRKN)) decreases p(HGNC:CCNE1) + a(CHEBI:"methylene blue") increases p(HGNC:BECN1) - pmid:14556719 + pubmed:29758300 - p(HGNC:AIMP2) increases bp(GO:"cell death") + a(CHEBI:"methylene blue") increases p(HGNC:MAP1LC3B) - - - pmid:14556719 + pubmed:29758300 - p(HGNC:PRKN, var("p.Lys161Asn")) association path(MESH:"Parkinsonian Disorders") + a(CHEBI:"methylene blue") decreases p(HGNC:MAPT) - pmid:14556719 + pubmed:30116051 - p(HGNC:PRKN, var("p.Lys161Asn")) increases p(HGNC:AIMP2, pmod(Ub)) + a(CHEBI:"methylene blue") decreases act(p(HGNC:MAPT)) - pmid:14556719 + pubmed:23528736 - p(HGNC:SYT11, pmod(Ub)) association bp(GO:"synaptic vesicle transport") + a(CHEBI:"methylene blue") decreases p(HGNC:MAPT) - pmid:14556719 + pubmed:29758300 - p(HGNC:SYT11, pmod(Ub)) association sec(a(CHEBI:neurotransmitter)) + a(CHEBI:"methylene blue") decreases p(HGNC:SQSTM1) - - - pmid:14556719 + pubmed:30116051 - a(GO:"actin filament") association p(HGNC:PRKN) + a(CHEBI:"methylene blue") increases p(HGNC:SQSTM1) - pmid:14556719 + pubmed:30116051 - p(HGNC:UBE3A) increases complex(a(HBP:"protein aggregates"), a(MESH:Neurons)) + a(CHEBI:"methylene blue") decreases a(CONSO:"Tau oligomers") - pmid:14556719 + pubmed:30116051 - act(p(HGNC:UBE3A)) decreases bp(GO:"cell death") + a(CHEBI:"methylene blue") increases bp(GO:autophagy) - pmid:22908190 + pubmed:23528736 - p(HGNC:UBE3A) increases deg(p(HGNC:ARC)) + a(CHEBI:"methylene blue") increases bp(GO:autophagy) - + + + pubmed:29626319 + + a(CHEBI:"methylene blue") increases bp(GO:autophagy) + - pmid:14556719 + pubmed:30116051 - p(HGNC:UCHL1, var("p.Ile93Met")) association path(MESH:"Parkinson Disease") + a(CHEBI:"methylene blue") increases act(p(FPLX:AMPK)) - - - pmid:14556719 + pubmed:30116051 - complex(p(HGNC:UCHL1), p(HGNC:UCHL1)) increases bp(GO:"protein K63-linked ubiquitination") + a(CHEBI:"methylene blue") increases p(HGNC:MAP1LC3A) - pmid:22908190 + pubmed:24027553 - p(HGNC:SNCA, pmod(Ub)) positiveCorrelation p(HGNC:SNCA) + a(CHEBI:"methylene blue") increases bp(MESH:Autophagy) - pmid:22908190 + pubmed:24027553 - p(HGNC:SNCA, pmod(Ub)) positiveCorrelation path(MESH:"Parkinson Disease") + a(CHEBI:"methylene blue") increases bp(MESH:Autophagy) - pmid:22908190 + pubmed:22611162 - p(HGNC:SNCA, pmod(Ub)) positiveCorrelation path(MESH:Dementia) + a(CHEBI:"methylene blue") increases bp(GO:locomotion) - pmid:14556719 + pubmed:29191965 - p(HGNC:UCHL3) decreases path(MESH:"Deglutition Disorders") + a(CHEBI:"methylene blue") increases bp(GO:locomotion) - pmid:14556719 + pubmed:22611162 - p(HGNC:UCHL3) positiveCorrelation a(MESH:"Solitary Nucleus") + a(CHEBI:"methylene blue") decreases a(CONSO:"Tau aggregates") - pmid:14556719 + pubmed:23528736 - p(HGNC:UCHL3) positiveCorrelation a(MESH:"Area Postrema") + a(CHEBI:"methylene blue") decreases a(CONSO:"Tau aggregates") - pmid:14556719 + pubmed:29191965 - a(MESH:"Solitary Nucleus") positiveCorrelation p(HGNC:UCHL1) + a(CHEBI:"methylene blue") decreases a(CONSO:"Tau aggregates") - pmid:14556719 + pubmed:23528736 - a(MESH:"Solitary Nucleus") positiveCorrelation p(HGNC:UCHL3) + a(CHEBI:"methylene blue") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:14556719 + pubmed:23528736 - a(MESH:"Area Postrema") positiveCorrelation p(HGNC:UCHL1) + a(CHEBI:"methylene blue") increases bp(GO:cognition) - pmid:14556719 + pubmed:21882945 - a(MESH:"Area Postrema") positiveCorrelation p(HGNC:UCHL3) + a(CHEBI:"methylene blue") decreases act(p(INTERPRO:"Heat shock protein 70 family")) - pmid:14556719 + pubmed:26751493 - bp(HBP:"Alpha-synuclein Oligomerization") positiveCorrelation p(HGNC:SNCA) + a(CHEBI:"methylene blue") decreases p(CONSO:"Tau aggregates") - pmid:14556719 + pubmed:26751493 - bp(HBP:"Alpha-synuclein Oligomerization") increases a(HBP:"alpha-synuclein fibrils") + a(CHEBI:"methylene blue") increases bp(GO:"protein catabolic process") - pmid:14556719 + pubmed:26751493 - a(HBP:"alpha-synuclein fibrils") increases a(HBP:"alpha-synuclein aggregates") + a(CHEBI:"methylene blue") association bp(GO:"response to oxidative stress") - pmid:14556719 + pubmed:26751493 - p(HGNC:SNCA, pmod(Glyco)) association p(HGNC:PRKN) + a(CHEBI:"methylene blue") decreases act(p(HGNC:CASP1)) - + + + pubmed:26751493 + + a(CHEBI:"methylene blue") decreases act(p(HGNC:CASP3)) + - pmid:14556719 + pubmed:26751493 - complex(a(HBP:"alpha-synuclein aggregates"), p(HGNC:PSMC4)) decreases act(complex(GO:"proteasome complex")) + a(CHEBI:"methylene blue") increases bp(GO:"energy reserve metabolic process") - + + + pubmed:26751493 + + a(CHEBI:"methylene blue") isA a(CHEBI:antioxidant) + - pmid:14556719 + pubmed:27708431 - complex(p(HGNC:PSMC4), p(HGNC:SNCA)) decreases act(complex(GO:"proteasome complex")) + a(CHEBI:"methylene blue") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) - - - pmid:29191965 + pubmed:27708431 - p(HGNC:TH) regulates a(CHEBI:dopamine) + a(CHEBI:"methylene blue") decreases act(p(HGNC:MARK4), ma(go:0016301 ! "kinase activity")) - pmid:29191965 + pubmed:27708431 - p(HGNC:TH) regulates a(CHEBI:serotonin) + a(CHEBI:"methylene blue") increases deg(p(HGNC:MARK4)) - pmid:29191965 + pubmed:27708431 - p(HGNC:TH) regulates act(p(HGNC:DDC)) + a(CHEBI:"methylene blue") increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:14556719 + pubmed:28287136 - g(HGNC:PARK7, var("?")) association path(MESH:"Parkinsonian Disorders") + a(CHEBI:"methylene blue") decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) - pmid:14556719 + pubmed:30515821 - p(HGNC:PARK7, pmod(Sumo)) regulates act(p(HGNC:PARK7)) + a(CHEBI:ATP) increases a(CHEBI:"reactive oxygen species") @@ -115815,94 +117082,91 @@

Statements

+ + - pmid:14556719 + pubmed:25437566 - complex(p(HGNC:PARK7), p(HGNC:PIAS2)) increases p(HGNC:PARK7, pmod(Sumo)) + a(CHEBI:ATP) association act(p(FPLX:HSP90)) - pmid:14556719 + pubmed:23746257 - p(HGNC:PARK7, var("p.Leu166Pro")) association path(MESH:"Parkinsonian Disorders") + a(CHEBI:ATP) regulates act(p(FPLX:HSP90)) - pmid:14556719 + pubmed:25437566 - p(HGNC:PARK7, var("p.Leu166Pro")) increases deg(p(HGNC:PARK7)) + a(CHEBI:ATP) association act(p(FPLX:HSPA)) - pmid:14556719 + pubmed:23746257 - p(HGNC:PARK7, var("p.Leu166Pro")) increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + a(CHEBI:ATP) regulates act(p(FPLX:HSPA)) - pmid:14556719 + pubmed:25437566 - p(HGNC:CFTR, var("p.Phe508del")) increases deg(p(HGNC:CFTR)) + a(CHEBI:ATP) association act(p(HGNC:HSPD1)) - pmid:14556719 + pubmed:25437566 - p(HGNC:CFTR, var("p.Phe508del")) increases path(MESH:"Cystic Fibrosis") + a(CHEBI:ATP) association act(p(HGNCGENEFAMILY:"AAA ATPases")) - - - pmid:14556719 - - deg(p(HGNC:CFTR)) increases path(MESH:"Cystic Fibrosis") - + - pmid:29311797 + pubmed:23746257 - path(MESH:"Cystic Fibrosis") association p(HGNC:STUB1) + a(CHEBI:ATP) regulates act(p(HGNCGENEFAMILY:Chaperonins)) - pmid:29311797 + pubmed:23746257 - path(MESH:"Cystic Fibrosis") association p(HGNC:AHSA1) + a(CHEBI:ATP) causesNoChange act(p(FPLX:HSPB)) - pmid:14556719 + pubmed:23746257 - p(HGNC:SEC61A1) increases tloc(p(MESH:Proteins, pmod(HBP:misfolding)), fromLoc(GO:"endoplasmic reticulum lumen"), toLoc(GO:cytosol)) + a(CHEBI:ATP) regulates complex(p(HGNC:HSPD1), p(HGNC:HSPE1)) @@ -115913,1207 +117177,1237 @@

Statements

- - - - - pmid:14556719 + pubmed:24457024 - g(HGNC:MAPT, var("?")) increases path(MESH:"Pick Disease of the Brain") + a(CHEBI:ATP) decreases complex(a(MESH:Proteins), a(MESH:Ubiquitin)) - - - pmid:27574109 + pubmed:24457024 - path(MESH:"Pick Disease of the Brain") positiveCorrelation a(HBP:"3R tau") + a(CHEBI:ATP) increases tloc(a(MESH:Proteins), fromLoc(GO:cytosol), toLoc(CONSO:"20 S Proteasome")) - pmid:27574109 + pubmed:19251756 - path(MESH:"Pick Disease of the Brain") positiveCorrelation a(HBP:"4R tau") + a(CHEBI:ATP) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:27574109 + pubmed:24561250 - path(MESH:"Pick Disease of the Brain") positiveCorrelation p(HGNC:MAPT) + a(CHEBI:ATP) increases act(complex(GO:"inflammasome complex")) - pmid:27574109 + pubmed:24561250 - path(MESH:"Pick Disease of the Brain") positiveCorrelation p(HGNC:MAPT) + a(CHEBI:ATP) increases act(complex(GO:"inflammasome complex")) - pmid:27574109 + pubmed:24561250 - path(MESH:"Pick Disease of the Brain") positiveCorrelation a(HBP:"phosphatase-activating domain") + a(CHEBI:ATP) increases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) - pmid:27574109 + pubmed:24561250 - path(MESH:"Pick Disease of the Brain") positiveCorrelation a(HBP:"Tau oligomers") + a(CHEBI:ATP) increases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) - pmid:27574109 + pubmed:24561250 - path(MESH:"Pick Disease of the Brain") positiveCorrelation a(HBP:"Tau oligomers") + a(CHEBI:ATP) increases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) - pmid:27574109 + pubmed:24561250 - path(MESH:"Pick Disease of the Brain") positiveCorrelation composite(a(HBP:"phosphatase-activating domain"), p(HGNC:MAPT)) + a(CHEBI:ATP) increases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) - pmid:29311797 + pubmed:28499950 - path(MESH:"Pick Disease of the Brain") isA path(MESH:Tauopathies) + act(p(HGNC:CASP3)) directlyIncreases rxn(reactants(p(HGNC:MAPT)), products(p(HGNC:MAPT, frag("152_*")))) - - - pmid:27260836 - - path(MESH:"Pick Disease of the Brain") positiveCorrelation complex(GO:"Pick body") - + - pmid:26655600 + pubmed:23516100 - path(MESH:"Pick Disease of the Brain") positiveCorrelation p(HBP:"3R tau", loc(GO:"Pick body")) + act(p(HGNC:CASP3)) increases complex(p(HGNC:CASP3), p(HGNC:MAPT, frag("1_421"))) - pmid:22057784 + pubmed:23516100 - path(MESH:"Pick Disease of the Brain") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) + p(HGNC:CASP3) increases p(HGNC:MAPT, frag("1_421")) - pmid:22057784 + pubmed:26631930 - path(MESH:"Pick Disease of the Brain") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) + p(HGNC:CASP3) increases p(HGNC:MAPT, frag("1_421")) - pmid:22057784 + pubmed:23516100 - path(MESH:"Pick Disease of the Brain") positiveCorrelation p(HGNC:MAPT, pmod(NO, Tyr, 29)) + p(HGNC:CASP3) increases p(HGNC:APP, frag("219_*")) - - - - - pmid:14556719 + pubmed:23516100 - composite(a(CHEBI:"amyloid-beta"), p(HGNC:MAPT, var("?"))) increases path(MESH:"Alzheimer Disease") + p(HGNC:CASP3) increases p(HGNC:SNCA, frag("1_122")) - pmid:14556719 + pubmed:23516100 - a(CHEBI:lactacystin) decreases act(complex(GO:"proteasome complex")) + p(HGNC:CASP3) increases p(HGNC:SNCA, frag("1_119")) - pmid:14556719 + pubmed:23516100 - a(CHEBI:lactacystin) increases bp(GO:"cell death") + p(HGNC:CASP3) increases p(HGNC:SNCA, frag("1_133")) - pmid:22908190 + pubmed:23516100 - a(CHEBI:lactacystin) decreases bp(GO:"long-term memory") + p(HGNC:CASP3) increases p(HGNC:MAPT, frag("?")) - pmid:30145931 + pubmed:23516100 - a(CHEBI:lactacystin) decreases act(p(FPLX:Proteasome)) + p(HGNC:CASP3) increases p(HGNC:MAPT, frag("?")) - pmid:23528736 + pubmed:23516100 - a(CHEBI:lactacystin) decreases act(p(FPLX:Proteasome)) + p(HGNC:CASP3) increases p(HGNC:APP, frag("?")) - pmid:24027553 + pubmed:23516100 - a(CHEBI:lactacystin) decreases deg(p(HGNC:MAPT)) + p(HGNC:CASP3) increases p(HGNC:MAPT, frag("421_*"), var("?")) - pmid:24027553 + pubmed:23516100 - a(CHEBI:lactacystin) increases p(HGNC:MAPT) + p(HGNC:CASP3) increases p(HGNC:HTT, frag("1_513")) - pmid:23528736 + pubmed:23516100 - a(CHEBI:lactacystin) decreases deg(p(HGNC:MAPT)) + p(HGNC:CASP3) increases p(HGNC:HTT, frag("1_548")) - pmid:24027553 + pubmed:23516100 - a(CHEBI:lactacystin) decreases act(p(HBP:"20 S Proteasome")) + p(HGNC:CASP3) increases p(HGNC:HTT, frag("1_552")) - pmid:24027553 + pubmed:23516100 - a(CHEBI:lactacystin) increases p(HGNC:MAPT, var("p.P301L")) + act(p(HGNC:CASP3)) increases p(HGNC:TARDBP, frag("?")) + + - pmid:24027553 + pubmed:21722302 - a(CHEBI:lactacystin) decreases act(p(HGNCGENEFAMILY:Proteasome)) + act(p(HGNC:CASP3)) increases bp(MESH:"Cell Death") - pmid:14556719 + pubmed:29758300 - a(MESH:Prions) increases path(MESH:"Prion Diseases") + p(HGNC:CASP3) increases p(HGNC:BECN1, frag("?")) - pmid:14556719 + pubmed:30116051 - a(MESH:Prions) increases path(MESH:"Encephalopathy, Bovine Spongiform") + act(p(HGNC:CASP3)) increases p(HGNC:BECN1, frag("?")) - + + + pubmed:24027553 + + act(p(HGNC:CASP3)) increases p(HGNC:MAPT, frag("?_*")) + - + + + pubmed:24027553 + + act(p(HGNC:CASP3)) increases deg(p(HGNC:MAPT)) + - pmid:14556719 + pubmed:24027553 - complex(p(HGNC:HSPA5), p(HGNC:PRNP)) increases bp(GO:"protein folding") + act(p(HGNC:CASP3)) increases p(CONSO:"Tau C3") - pmid:14556719 + pubmed:24027553 - p(HGNC:SOD1, var("?")) association path(MESH:"Amyotrophic Lateral Sclerosis") + act(p(HGNC:CASP3)) increases p(CONSO:"Tau C3") + + - pmid:30985105 + pubmed:24027553 - p(HGNC:SOD1, var("?")) increases path(MESH:"Amyotrophic Lateral Sclerosis") + act(p(HGNC:CASP3)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:14556719 + pubmed:26631930 - p(HGNC:SOD1, var("?")) increases bp(GO:"response to oxidative stress") + p(HGNC:CASP3) increases rxn(reactants(p(HGNC:MAPT)), products(p(HGNC:MAPT, frag("1_421")), p(HGNC:MAPT, frag("421_*")))) - pmid:14556719 + pubmed:29238289 - p(HGNC:SOD1, var("?")) increases bp(GO:"response to oxidative stress") + act(p(HGNC:CASP3)) increases rxn(reactants(p(HGNC:MAPT)), products(p(HGNC:MAPT, frag("1_421")), p(HGNC:MAPT, frag("421_*")))) - pmid:14556719 + pubmed:27068745 - p(HGNC:SOD1, var("?")) increases bp(GO:"cell death") + p(HGNC:CASP3) association act(p(FPLX:JNK)) - pmid:14556719 + pubmed:27068745 - p(HGNC:SOD1, var("?")) negativeCorrelation act(complex(GO:"proteasome complex")) + p(HGNC:CASP3) association act(p(HGNC:MAP3K5)) - pmid:14556719 + pubmed:27068745 - p(HGNC:SOD1, var("?")) increases act(complex(GO:"proteasome complex")) + p(HGNC:CASP3) increases bp(GO:"neuron apoptotic process") - pmid:18930136 + pubmed:30837838 - p(HGNC:SOD1, var("?")) association p(HGNC:SQSTM1) + p(HGNC:CASP3) increases p(HGNC:TARDBP, frag("?"), var("p.Asp169Gly")) - pmid:27181519 + pubmed:30837838 - p(HGNC:SOD1, var("?")) association bp(GO:autophagy) + p(HGNC:CASP3) decreases p(HGNC:TARDBP, frag("?"), var("p.Ala90Val")) - pmid:14556719 + pubmed:27314526 - p(HGNC:SOD1, pmod(HBP:misfolding)) increases a(HBP:"protein aggregates") + act(p(HGNC:CASP3)) increases bp(GO:"neuron death") - pmid:14556719 + pubmed:30444369 - p(HGNC:RNF19A) decreases bp(GO:"cell death") + p(HGNC:BCL2L11) increases bp(GO:"apoptotic process") + + - pmid:14556719 + pubmed:23528736 - p(HGNC:RNF19A) increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + p(HGNC:BCL2L11) decreases bp(GO:autophagy) - pmid:14556719 + pubmed:30444369 - p(HGNC:RNF19A) increases deg(p(HGNC:SOD1, var("?"))) + act(p(HGNC:PRDX2)) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:14556719 + pubmed:30444369 - p(HGNC:UBL5) positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") + p(HGNC:PRDX2) positiveCorrelation path(MESH:"Alzheimer Disease") - - - pmid:14556719 + pubmed:30444369 - composite(a(CHEBI:lactacystin), p(HGNC:SOD1, var("?"))) increases bp(GO:"cell death") + p(HGNC:PRDX2, pmod(go:0006468 ! "protein phosphorylation", Thr, 89)) decreases act(p(HGNC:PRDX2)) - pmid:14556719 + pubmed:30444369 - p(HGNC:CREBBP) association a(MESH:"Inclusion Bodies") + p(HGNC:SH3GL2) increases bp(GO:"synaptic vesicle endocytosis") - pmid:26631930 + pubmed:30444369 - p(HGNC:CREBBP) increases p(HGNC:MAPT, pmod(Ac, Lys)) + p(HGNC:SH3GL2) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:14556719 + pubmed:30444369 - p(HGNC:CDC34, var("?")) decreases a(MESH:"Inclusion Bodies") + p(HGNC:SH3GL2) increases act(p(HGNC:MAP3K1)) - pmid:14556719 + pubmed:30444369 - p(HGNC:CDC34, var("?")) increases bp(GO:"cell death") + p(HGNC:SH3GL2) association bp(GO:"neuron projection development") - - - pmid:24457024 + pubmed:30444369 - p(HGNC:CDC34) increases complex(a(MESH:Ubiquitin), p(HGNC:CDC34)) + p(HGNC:SH3GL2) association bp(GO:"regulation of synaptic plasticity") - - - - - - - - - pmid:14556719 + pubmed:30444369 - p(HGNC:RAD23A) increases tloc(p(HGNC:ATXN3, pmod(Ub)), fromLoc(GO:cytosol), toLoc(GO:"proteasome complex")) + p(HGNC:SH3GL2) association bp(GO:"neuron death") - - - - - pmid:14556719 + pubmed:30444369 - composite(a(CHEBI:cystamine), p(HGNC:ATN1)) decreases a(HBP:"protein aggregates") + act(p(HGNC:MAP3K1)) increases bp(GO:"JNK cascade") - pmid:14556719 + pubmed:30444369 - composite(a(CHEBI:cystamine), p(HGNC:ATN1)) decreases bp(GO:"cell death") + bp(GO:"neuron projection development") association p(HGNC:SH3GL2) - - - - - pmid:14556719 + pubmed:18986241 - composite(a(CHEBI:cystamine), p(HGNC:AR, var("?"))) decreases a(HBP:"protein aggregates") + bp(GO:"neuron projection development") association act(p(HGNCGENEFAMILY:"Mitogen-activated protein kinases")) - pmid:14556719 + pubmed:20133804 - composite(a(CHEBI:cystamine), p(HGNC:AR, var("?"))) decreases bp(GO:"cell death") + bp(GO:"neuron projection development") negativeCorrelation p(RGD:Fkbp4) - pmid:14556719 + pubmed:30444369 - a(CHEBI:"Congo Red") decreases a(HBP:"huntingtin aggregates") + a(CONSO:AG18051) decreases act(p(HGNC:HSD17B10)) - pmid:14556719 + pubmed:30444369 - a(CHEBI:"Congo Red") increases act(complex(GO:"proteasome complex")) + a(CONSO:AG18051) decreases act(a(CONSO:"amyloid-beta aggregates")) - pmid:22908190 + pubmed:30444369 - p(FPLX:Caspase) increases deg(p(HGNC:MAPT)) + a(CONSO:RM-532-46) decreases act(p(HGNC:HSD17B10)) - pmid:29626319 + pubmed:30444369 - p(FPLX:Caspase) increases deg(p(HGNC:MAPT)) + a(PUBCHEM:33334) decreases complex(p(HGNC:APP), p(HGNC:HSD17B10)) - pmid:25374103 + pubmed:30444369 - p(FPLX:Caspase) increases path(MESH:Tauopathies) + a(PUBCHEM:33334) decreases act(p(HGNC:CSNK1A1)) + + - pmid:26631930 + pubmed:30444369 - p(FPLX:Caspase) increases p(HGNC:MAPT, frag("26_230")) + composite(a(PUBCHEM:208907), a(PUBCHEM:33334)) decreases act(p(HGNC:MAOA)) - + + + pubmed:29196815 + + path(MESH:Obesity) increases path(MESH:"Alzheimer Disease") + - pmid:22908190 + pubmed:29196815 - composite(a(MESH:Ubiquitin), p(HGNC:SQSTM1)) increases act(p(HGNC:VCP)) + path(MESH:"Diabetes Mellitus") increases path(MESH:"Alzheimer Disease") - pmid:22908190 + pubmed:26195256 - act(p(HGNC:VCP)) regulates bp(GO:"ERAD pathway") + path(MESH:"Diabetes Mellitus") increases path(MESH:"Alzheimer Disease") - pmid:22908190 + pubmed:30740335 - act(p(HGNC:VCP)) regulates a(GO:autophagosome) + path(MESH:"Diabetes Mellitus") association path(MESH:"Endoplasmic Reticulum Stress") - pmid:27181519 + pubmed:29626319 - p(HGNC:VCP) decreases a(GO:autophagosome) + path(MESH:"Diabetes Mellitus") negativeCorrelation p(HGNC:IDE) - pmid:24457024 + pubmed:29626319 - p(HGNC:VCP) increases bp(GO:"proteasomal protein catabolic process") + path(MESH:"Diabetes Mellitus") positiveCorrelation a(CHEBI:amyloid-beta) - pmid:24457024 + pubmed:29196815 - p(HGNC:VCP) increases bp(GO:"protein ubiquitination") + g(CONSO:CONSO00030) increases path(MESH:"Alzheimer Disease") - pmid:27181519 + pubmed:21718217 - p(HGNC:VCP) decreases complex(GO:"cytoplasmic stress granule") + g(CONSO:CONSO00030) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27181519 + pubmed:21718217 - p(HGNC:VCP) increases complex(GO:"cytoplasmic stress granule", loc(GO:autophagosome)) + g(CONSO:CONSO00030) association path(MESH:"Alzheimer Disease") - pmid:27181519 + pubmed:21718217 - p(HGNC:VCP) increases complex(GO:"cytoplasmic stress granule", loc(GO:autophagosome)) + g(CONSO:CONSO00030) increases a(CONSO:CONSO00018) - pmid:27181519 + pubmed:26837465 - p(HGNC:VCP) increases bp(GO:autophagy) + complex(GO:"neurofibrillary tangle") association p(HGNC:ESR1) - pmid:27181519 + pubmed:26837465 - p(HGNC:VCP) decreases p(HGNC:TARDBP) + complex(GO:"neurofibrillary tangle") association p(HGNC:ESR1) - pmid:27181519 + pubmed:24368848 - p(HGNC:VCP) increases bp(GO:"stress granule assembly") + complex(GO:"neurofibrillary tangle") causesNoChange act(a(MESH:Neurons)) - pmid:22908190 + pubmed:23407988 - path(HBP:"granulovacuolar degeneration") association a(MESH:Ubiquitin) + complex(GO:"neurofibrillary tangle") decreases complex(GO:"dendritic tree") - pmid:22908190 + pubmed:10391244 - path(HBP:"granulovacuolar degeneration") association a(MESH:Ubiquitin) + complex(GO:"neurofibrillary tangle") association complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)), p(HGNC:PIN1, frag("5_39"))) - pmid:11943212 + pubmed:10391244 - path(HBP:"granulovacuolar degeneration") association complex(p(HGNC:MAPT, pmod(Ph, Ser, 262)), p(HGNC:MARK4, pmod(Ph))) + complex(GO:"neurofibrillary tangle") positiveCorrelation p(HGNC:CDK1) - pmid:11943212 + pubmed:12714745 - path(HBP:"granulovacuolar degeneration") positiveCorrelation path(MESH:"Alzheimer Disease") + complex(GO:"neurofibrillary tangle") positiveCorrelation g(DBSNP:rs104893877) - pmid:22908190 + pubmed:29196815 - a(MESH:"Neuropil Threads") association a(MESH:Ubiquitin) + a(CONSO:CONSO00074) increases bp(GO:"neuron death") - pmid:26195256 + pubmed:29196815 - a(MESH:"Neuropil Threads") association p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + a(CONSO:CONSO00074) increases bp(GO:"neuron death") - pmid:22817713 + pubmed:29196815 - a(MESH:"Neuropil Threads") association path(MESH:"Alzheimer Disease") + a(CONSO:CONSO00074) positiveCorrelation bp(GO:"neuron death") - pmid:23088643 + pubmed:21718217 - a(MESH:"Neuropil Threads") association p(HBP:"Tau epitope, AT8") + a(CONSO:CONSO00074) increases bp(GO:"neuron death") - pmid:22908190 + pubmed:29196815 - bp(GO:"histone H2B ubiquitination") association bp(MESH:"Transcription, Genetic") + a(CONSO:CONSO00074) decreases a(MESH:Synapses) - pmid:22908190 + pubmed:29196815 - bp(MESH:"Transcription, Genetic") association bp(GO:"histone H2B ubiquitination") + a(CONSO:CONSO00074) decreases a(MESH:Synapses) - pmid:22908190 + pubmed:29196815 - p(HBP:"Tau isoform F (441 aa)", pmod(Ub, Lys, 254)) association a(HBP:"paired helical filaments") + a(CONSO:CONSO00074) decreases a(MESH:Synapses) - pmid:22908190 + pubmed:29196815 - p(HBP:"Tau isoform F (441 aa)", pmod(Ub, Lys, 257)) association a(HBP:"paired helical filaments") + a(CONSO:CONSO00074) decreases bp(GO:memory) - pmid:22908190 + pubmed:29196815 - p(HBP:"Tau isoform F (441 aa)", pmod(Ub, Lys, 311)) association a(HBP:"paired helical filaments") + a(CONSO:CONSO00074) decreases bp(GO:memory) - pmid:22908190 + pubmed:29196815 - p(HBP:"Tau isoform F (441 aa)", pmod(Ub, Lys, 317)) association a(HBP:"paired helical filaments") + a(CONSO:CONSO00074) decreases bp(GO:memory) - pmid:22908190 + pubmed:29196815 - p(HBP:"Tau isoform F (441 aa)", pmod(UbK48)) association a(HBP:"paired helical filaments") + a(CONSO:CONSO00074) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:22908190 + pubmed:29196815 - p(HBP:"Tau isoform F (441 aa)", pmod(UbK48)) association a(HBP:"paired helical filaments") + a(CONSO:CONSO00074) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:22908190 + pubmed:29196815 - p(HBP:"Tau isoform F (441 aa)", pmod(UbPoly, Lys, 6)) association a(HBP:"paired helical filaments") + a(CONSO:CONSO00074) decreases bp(GO:"neuronal signal transduction") - pmid:22908190 + pubmed:29196815 - p(HBP:"Tau isoform F (441 aa)", pmod(UbPoly, Lys, 11)) association a(HBP:"paired helical filaments") + a(CONSO:CONSO00074) increases path(MESH:Dementia) - + + + pubmed:29196815 + + a(CONSO:CONSO00074) decreases bp(GO:"long-term synaptic potentiation") + + + + pubmed:29196815 + + a(CONSO:CONSO00074) decreases bp(GO:"long-term synaptic potentiation") + + - pmid:26751493 + pubmed:29196815 - p(HBP:"Tau aggregates") association a(CHEBI:heparin) + a(CONSO:CONSO00074) decreases bp(GO:"signal release from synapse") - pmid:26751493 + pubmed:29196815 - p(HBP:"Tau aggregates") increases complex(a(CHEBI:heparin), p(HBP:"Tau aggregates")) + a(CONSO:CONSO00074) increases bp(GO:"long term synaptic depression") - pmid:26751493 + pubmed:29196815 - p(HBP:"Tau aggregates") partOf complex(a(CHEBI:heparin), p(HBP:"Tau aggregates")) + a(CONSO:CONSO00074) increases p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation")) - pmid:24869773 + pubmed:29196815 - p(HBP:"Tau aggregates") association p(HGNC:MAPT, pmod(Me, Lys, 311)) + a(CONSO:CONSO00074) increases path(MESH:"Neuroaxonal Dystrophies") - pmid:19517062 + pubmed:29196815 - p(HBP:"Tau aggregates") increases bp(GO:"apoptotic process") + a(CONSO:CONSO00074) increases bp(GO:"microglial cell activation") - pmid:19517062 + pubmed:29196815 - p(HBP:"Tau aggregates") increases bp(GO:"necrotic cell death") + a(CONSO:CONSO00074) increases bp(GO:"astrocyte activation") - pmid:26751493 + pubmed:29196815 - p(HBP:"Tau aggregates") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 274)) + a(CONSO:CONSO00074) positiveCorrelation bp(GO:"astrocyte activation") - pmid:24033439 + pubmed:29196815 - p(HBP:"Tau aggregates") increases a(GO:"neurofibrillary tangle") + a(CONSO:CONSO00074) positiveCorrelation a(CHEBI:"amyloid fibril") - pmid:28760828 + pubmed:29196815 - p(HBP:"Tau aggregates") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 324)) + a(CONSO:CONSO00074) increases act(p(HGNC:GRIN1)) - pmid:28500862 + pubmed:29196815 - p(HBP:"Tau aggregates") positiveCorrelation a(CHEBI:"amyloid-beta") + a(CONSO:CONSO00074) regulates tloc(p(HGNC:GRIA1), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + pubmed:29196815 + + a(CONSO:CONSO00074) regulates tloc(p(HGNC:GRIA2), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + - pmid:22908190 + pubmed:29196815 - a(GO:"Pick body") association p(HGNC:MAPT) + a(CONSO:CONSO00074) increases act(p(HGNC:NGFR)) - pmid:27574109 + pubmed:29196815 - a(GO:"Pick body") association p(HGNC:MAPT) + a(CONSO:CONSO00074) decreases p(HGNC:INSR) - pmid:22908190 + pubmed:29196815 - a(GO:"Pick body") association a(MESH:Ubiquitin) + a(CONSO:CONSO00074) negativeCorrelation a(CONSO:CONSO00352) - pmid:27574109 + pubmed:29196815 - a(GO:"Pick body") association a(HBP:"Tau oligomers") + a(CONSO:CONSO00074) positiveCorrelation path(MESH:"Cognitive Dysfunction") - pmid:27574109 + pubmed:29196815 - a(GO:"Pick body") association a(HBP:"phosphatase-activating domain") + a(CONSO:CONSO00074) positiveCorrelation path(MESH:"Cognitive Dysfunction") - pmid:22908190 + pubmed:21718217 - p(HGNC:TARDBP, pmod(Ub)) positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") + a(CONSO:CONSO00074) decreases bp(GO:"synaptic signaling") - pmid:22908190 + pubmed:19293145 - p(HGNC:TARDBP, pmod(Ub)) positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") + a(MESH:Synapses) increases bp(GO:cognition) - pmid:22908190 + pubmed:29196815 - p(HGNC:TARDBP, pmod(Ub)) positiveCorrelation path(MESH:"Frontotemporal Lobar Degeneration") + a(CHEBI:"amyloid fibril") causesNoChange bp(GO:memory) - + + + pubmed:29196815 + + a(CHEBI:"amyloid fibril") positiveCorrelation a(CONSO:CONSO00074) + - + + + pubmed:22110360 + + p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation")) increases a(CHEBI:amyloid-beta) + - pmid:22908190 + pubmed:24653673 - complex(a(MESH:Proteins), a(MESH:Ubiquitin), p(HGNC:UBA2), p(HGNC:UBA3)) increases p(MESH:Proteins, pmod(Ub)) + p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation act(p(HGNC:GSK3B)) - pmid:24457024 + pubmed:24653673 - complex(a(MESH:Proteins), a(MESH:Ubiquitin), p(HGNC:UBA2), p(HGNC:UBA3)) increases bp(GO:"protein ubiquitination") + p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation act(p(HGNC:CDK5)) - pmid:22908190 + pubmed:24653673 - p(HGNC:UBE4A) increases bp(GO:"protein polyubiquitination") + p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation act(p(FPLX:ERK)) - + + + pubmed:24653673 + + p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation a(CHEBI:homocysteine) + - pmid:22908190 + pubmed:24653673 - complex(a(GO:"proteasome regulatory particle"), p(MESH:Proteins, pmod(Ub))) increases tloc(a(MESH:Proteins), fromLoc(GO:"proteasome regulatory particle"), toLoc(HBP:"20 S Proteasome")) + p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) - + + + pubmed:29196815 + + act(p(HGNC:GRIN1)) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(GO:"extracellular region"), toLoc(GO:"intracellular part")) + - pmid:22908190 + pubmed:29196815 - complex(a(GO:"proteasome regulatory particle"), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) negativeCorrelation act(complex(GO:"proteasome complex")) + act(p(HGNC:GRIN1)) increases path(CONSO:CONSO00068) - + + + pubmed:29196815 + + act(p(HGNC:GRIN1)) increases path(CONSO:CONSO00037) + - pmid:22908190 + pubmed:29196815 - complex(a(GO:"proteasome regulatory particle"), a(HBP:"paired helical filaments")) decreases act(complex(GO:"proteasome complex")) + act(p(HGNC:GRIN1)) decreases a(MESH:Synapses) - pmid:22908190 + pubmed:19419557 - p(HBP:"Tau aggregates", pmod(HBP:hyperphosphorylation)) increases p(HBP:"Tau aggregates", pmod(HBP:hyperphosphorylation), pmod(Ub)) + act(p(HGNC:GRIN1)) increases a(CHEBI:"nitric oxide") - pmid:22908190 + pubmed:19419557 - p(HBP:"UBB+1") positiveCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNC:GRIN1)) increases bp(GO:"negative regulation of calcium-mediated signaling") + + - pmid:23528736 + pubmed:27041503 - p(HBP:"UBB+1") positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:GRIA1) decreases bp(GO:"long-term synaptic potentiation") - pmid:22908190 + pubmed:24760868 - p(HBP:"UBB+1") positiveCorrelation path(MESH:"Niemann-Pick Diseases") + p(HGNC:GRIA1) positiveCorrelation bp(GO:"long-term synaptic potentiation") - - - pmid:22908190 + pubmed:24760868 - p(HBP:"UBB+1") decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + p(HGNC:GRIA1) positiveCorrelation bp(GO:"long-term synaptic potentiation") - pmid:22908190 + pubmed:23393546 - p(HBP:"UBB+1") decreases bp(GO:memory) + p(HGNC:GRIA2) association path(DOID:"Huntington's disease") - pmid:23528736 + pubmed:29196815 - p(HBP:"UBB+1") association a(MESH:"Neurofibrillary Tangles") + a(CONSO:CONSO00075) decreases p(MGI:Adrb2) - - - pmid:22908190 + pubmed:29196815 - p(HBP:"UBB+1", pmod(UbPoly)) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + a(CONSO:CONSO00075) increases bp(GO:"microglial cell activation") - pmid:22908190 + pubmed:29196815 - p(HBP:"UBB+1", pmod(UbPoly)) decreases deg(p(HBP:"UBB+1", pmod(UbPoly))) + a(CONSO:CONSO00075) decreases bp(GO:"long-term synaptic potentiation") - pmid:22908190 + pubmed:29196815 - p(HGNC:UCHL1, pmod(GO:"protein oxidation")) negativeCorrelation a(GO:"neurofibrillary tangle") + complex(a(CONSO:CONSO00074), p(HGNC:PRNP)) decreases bp(GO:"regulation of synaptic plasticity") @@ -117122,57 +118416,73 @@

Statements

+ + + pubmed:29196815 + + p(HGNC:PRNP) decreases a(CHEBI:"amyloid fibril") + + + + - pmid:22908190 + pubmed:21722302 - p(HGNC:UBQLN1, var("?")) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:PRNP) association bp(GO:"neuron development") - pmid:22908190 + pubmed:21722302 - deg(p(FPLX:PKA, pmod(Ub))) increases act(p(FPLX:PKA)) + p(HGNC:PRNP) association bp(GO:"neuron death") - pmid:22908190 + pubmed:21722302 - p(HGNC:ARC) regulates bp(GO:"synapse maturation") + p(HGNC:PRNP) decreases bp(MESH:"Oxidative Stress") - pmid:22908190 + pubmed:21722302 - act(a(MESH:Neurites)) negativeCorrelation p(HGNC:APP, var("?")) + p(HGNC:PRNP) decreases p(HGNC:TNF) - pmid:28877763 + pubmed:21722302 - a(MESH:Neurites) positiveCorrelation act(p(MGI:Syk)) + p(HGNC:PRNP) decreases p(HGNC:BAX) + + + pubmed:14556719 + + p(HGNC:PRNP) increases complex(a(CHEBI:"copper(2+)"), p(HGNC:PRNP)) + + @@ -117181,14 +118491,19 @@

Statements

- pmid:22908190 + pubmed:14556719 - complex(p(HGNC:HSPA8), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)), p(HGNC:STUB1)) increases deg(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) + tloc(p(HGNC:PRNP), fromLoc(MESH:"Endoplasmic Reticulum"), toLoc(GO:cytosol)) increases deg(p(HGNC:PRNP)) - + + + pubmed:28420982 + + p(HGNC:PRNP) association a(CONSO:"Tau oligomers") + @@ -117196,90 +118511,96 @@

Statements

- pmid:22908190 + pubmed:29196815 - complex(GO:"clathrin complex") increases bp(GO:"plasma membrane invagination") + a(CONSO:CONSO00023) increases a(CHEBI:"calcium(2+)") - pmid:22908190 + pubmed:29196815 - a(GO:caveola) increases bp(GO:"plasma membrane invagination") + a(CONSO:CONSO00023) increases complex(p(HGNC:GRIK1), p(HGNC:PRNP)) - pmid:22908190 + pubmed:29196815 - bp(GO:"bulk synaptic vesicle endocytosis") increases bp(GO:"plasma membrane invagination") + a(CONSO:CONSO00023) decreases bp(GO:"signal release from synapse") + + - pmid:29590627 + pubmed:29196815 - bp(GO:"bulk synaptic vesicle endocytosis") negativeCorrelation a(CHEBI:"cytochalasin D") + p(HGNC:NGFR) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:29590627 + pubmed:29196815 - bp(GO:"bulk synaptic vesicle endocytosis") positiveCorrelation bp(GO:"actin filament polymerization") + p(HGNC:NGFR) positiveCorrelation path(MESH:"Cognitive Dysfunction") - pmid:22908190 + pubmed:22236693 - p(HGNC:RAB7A) increases a(GO:endosome) + p(HGNC:NGFR) regulates act(p(HGNC:NTRK1)) - pmid:22908190 + pubmed:22236693 - p(HGNC:RAB7A) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:NGFR) positiveCorrelation bp(MESH:"Cell Survival") + + - pmid:22908190 + pubmed:22236693 - p(HGNC:RAB7A) increases complex(a(GO:"early endosome"), a(GO:"late endosome")) + p(HGNC:NGFR) increases complex(a(CHEBI:amyloid-beta), p(HGNC:NGFR)) + + - pmid:22908190 + pubmed:22236693 - p(HGNC:RAB7A) association bp(GO:"regulation of endosome size") + p(HGNC:NGFR) increases complex(p(HGNC:NGF), p(HGNC:NGFR)) - pmid:18930136 + pubmed:22236693 - p(HGNC:RAB7A) increases bp(GO:"autophagosome-lysosome fusion") + p(HGNC:NGFR) association bp(GO:"regulation of cell death") @@ -117288,568 +118609,583 @@

Statements

- pmid:29238289 + pubmed:18986241 - p(HGNC:RAB7A) association sec(p(HGNC:MAPT)) + p(HGNC:NGFR) association bp(GO:"regulation of neuron death") + + - pmid:27181519 + pubmed:18986241 - p(HGNC:RAB7A) association g(HGNC:C9orf72) + p(HGNC:NGFR) increases act(p(HGNC:BACE1)) - pmid:22908190 + pubmed:18986241 - act(a(GO:endosome)) increases bp(GO:"nerve growth factor signaling pathway") + p(HGNC:NGFR) increases a(CHEBI:amyloid-beta) + + - pmid:22908190 + pubmed:18986241 - act(a(GO:endosome)) decreases path(HBP:Neurodegeneration) + act(p(HGNC:NGFR)) association bp(GO:"sphingolipid metabolic process") - pmid:22908190 + pubmed:18986241 - complex(GO:"ESCRT complex") regulates tloc(a(MESH:Proteins), fromLoc(GO:cytoplasm), toLoc(GO:"multivesicular body")) + act(p(HGNC:NGFR)) increases bp(GO:"JNK cascade") - pmid:22908190 + pubmed:18986241 - p(HGNC:M6PR) increases tloc(a(MESH:Cathepsins), fromLoc(GO:"trans-Golgi network"), toLoc(GO:"multivesicular body")) + act(p(HGNC:NGFR)) increases bp(GO:"NIK/NF-kappaB signaling") - pmid:22908190 + pubmed:18986241 - a(MESH:Cathepsins) regulates deg(a(CHEBI:"amyloid-beta")) + act(p(HGNC:NGFR)) increases bp(GO:"protein kinase B signaling") - pmid:22908190 + pubmed:18986241 - sec(a(MESH:Cathepsins)) increases bp(GO:"apoptotic process") + act(p(HGNC:NGFR)) increases bp(GO:"MAPK cascade") - pmid:22908190 + pubmed:22142809 - p(HGNC:IGF2R) increases tloc(a(MESH:Cathepsins), fromLoc(GO:"trans-Golgi network"), toLoc(GO:"multivesicular body")) + p(HGNC:NGFR) association p(CONSO:RAC1b) - pmid:22908190 + pubmed:29196815 - bp(GO:"lysosomal microautophagy") increases tloc(a(GO:cytoplasm), fromLoc(GO:intracellular), toLoc(GO:lysosome)) + a(CONSO:CONSO00352) negativeCorrelation a(CONSO:CONSO00074) - pmid:22908190 + pubmed:29196815 - bp(GO:"lysosomal microautophagy") increases tloc(a(GO:cytoplasm), fromLoc(GO:intracellular), toLoc(GO:"multivesicular body")) + path(MESH:"Cognitive Dysfunction") positiveCorrelation a(CONSO:CONSO00074) - pmid:18930136 + pubmed:29196815 - bp(GO:"lysosomal microautophagy") increases tloc(a(GO:cytoplasm), fromLoc(GO:intracellular), toLoc(GO:lysosome)) + path(MESH:"Cognitive Dysfunction") positiveCorrelation a(CONSO:CONSO00074) - pmid:29626319 + pubmed:29196815 - bp(GO:"lysosomal microautophagy") increases bp(GO:"cellular protein catabolic process") + path(MESH:"Cognitive Dysfunction") positiveCorrelation p(HGNC:NGFR) - pmid:29626319 + pubmed:19293145 - bp(GO:"lysosomal microautophagy") increases deg(a(CHEBI:"amyloid-beta")) + path(MESH:"Cognitive Dysfunction") positiveCorrelation a(CONSO:"amyloid-beta oligomers") - pmid:29626319 + pubmed:19293145 - bp(GO:"lysosomal microautophagy") increases deg(a(CHEBI:"amyloid-beta")) + path(MESH:"Cognitive Dysfunction") association path(MESH:"Alzheimer Disease") - pmid:29626319 + pubmed:24511233 - bp(GO:"lysosomal microautophagy") increases deg(a(CHEBI:"amyloid-beta")) + path(MESH:"Cognitive Dysfunction") association path(MESH:"Alzheimer Disease") - pmid:29626319 + pubmed:24511233 - bp(GO:"lysosomal microautophagy") decreases a(HBP:"Tau aggregates") + path(MESH:"Cognitive Dysfunction") association path(MESH:"Alzheimer Disease") - pmid:29626319 + pubmed:26813123 - bp(GO:"lysosomal microautophagy") increases p(HGNC:MAPT, frag("?")) + path(MESH:"Cognitive Dysfunction") positiveCorrelation path(MESH:"Alzheimer Disease") - - - - - - - pmid:22908190 + pubmed:24511233 - complex(a(GO:"late endosome"), a(GO:autophagosome), a(GO:lysosome)) increases deg(a(MESH:Proteins)) + path(MESH:"Cognitive Dysfunction") association path(MESH:Schizophrenia) - pmid:29024336 + pubmed:26813123 - a(GO:"late endosome") increases deg(p(MGI:Mapt)) + path(MESH:"Cognitive Dysfunction") negativeCorrelation a(GO:synapse) - pmid:29024336 + pubmed:26813123 - a(GO:"late endosome") decreases deg(p(MGI:Mapt, var("p.Pro301Leu"))) + path(MESH:"Cognitive Dysfunction") association act(p(HGNC:CHRM1)) - pmid:29024336 + pubmed:18986241 - a(GO:"late endosome") decreases deg(p(MGI:Mapt, var("p.Ala152Thr"))) + path(MESH:"Cognitive Dysfunction") association p(HGNC:CHRM1) - pmid:29590627 + pubmed:27522251 - a(GO:"late endosome") association p(HGNC:MAPT, var("p.Pro301Ser")) + path(MESH:"Cognitive Dysfunction") increases path(MESH:"Plaque, Amyloid") - pmid:29590627 + pubmed:21482353 - a(GO:"late endosome") association a(HBP:"Tau aggregates") + path(MESH:"Cognitive Dysfunction") association p(HGNC:LYNX1) - + + + pubmed:18986241 + + path(MESH:"Cognitive Dysfunction") association path(CONSO:mdMCI) + - pmid:22908190 + pubmed:18986241 - complex(a(GO:"early endosome"), a(GO:autophagosome)) increases a(GO:amphisome) + path(MESH:"Cognitive Dysfunction") association path(MESH:"Prodromal Symptoms") - pmid:29590627 + pubmed:18986241 - a(GO:"early endosome") association p(HGNC:MAPT, var("p.Pro301Ser")) + path(MESH:"Cognitive Dysfunction") association path(CONSO:Neurodegeneration) - pmid:29590627 + pubmed:18986241 - a(GO:"early endosome") association a(HBP:"Tau aggregates") + path(MESH:"Cognitive Dysfunction") causesNoChange act(p(HGNC:CHAT)) - pmid:18930136 + pubmed:18986241 - a(GO:amphisome) increases complex(a(GO:amphisome), a(GO:lysosome)) + path(MESH:"Cognitive Dysfunction") increases act(p(HGNC:CHAT)) - pmid:22908190 + pubmed:18986241 - bp(GO:"response to nutrient") regulates p(HGNC:MTOR) + path(MESH:"Cognitive Dysfunction") increases act(p(HGNC:CHAT)) - pmid:22908190 + pubmed:18986241 - bp(GO:"regulation of endosome size") association path(MESH:"Neurodegenerative Diseases") + path(MESH:"Cognitive Dysfunction") decreases a(MESH:Synapses) - pmid:22908190 + pubmed:18986241 - bp(GO:"regulation of endosome size") association a(HBP:"Braak_Stage II") + path(MESH:"Cognitive Dysfunction") association p(HGNC:BCHE, var("p.Ala539Thr")) - pmid:22908190 + pubmed:18986241 - bp(GO:"regulation of endosome size") negativeCorrelation path(MESH:"Down Syndrome") + path(MESH:"Cognitive Dysfunction") increases a(MESH:"pro-nerve growth factor, human") - pmid:22908190 + pubmed:18986241 - bp(GO:"regulation of endosome size") association p(HGNC:RAB7A) + path(MESH:"Cognitive Dysfunction") increases act(p(HGNC:MMP9)) - pmid:22908190 + pubmed:18986241 - bp(GO:"regulation of endosome size") association p(HGNC:RAB5A) + path(MESH:"Cognitive Dysfunction") causesNoChange r(HGNC:CHAT) - pmid:22908190 + pubmed:18986241 - bp(GO:"regulation of endosome size") association p(HGNC:RAB4A) + path(MESH:"Cognitive Dysfunction") decreases p(CONSO:"3R tau") - pmid:22908190 + pubmed:11230871 - a(HBP:"Braak_Stage II") association bp(GO:"regulation of endosome size") + path(MESH:"Cognitive Dysfunction") negativeCorrelation p(FPLX:CHRN) - pmid:27574109 + pubmed:29687724 - a(HBP:"Braak_Stage II") association a(HBP:"Tau oligomers") + path(MESH:"Cognitive Dysfunction") association path(MESH:"Huntington Disease") - pmid:27574109 + pubmed:29687724 - a(HBP:"Braak_Stage II") association a(HBP:"phosphatase-activating domain") + path(MESH:"Cognitive Dysfunction") isA path(MESH:"Neurocognitive Disorders") - pmid:27574109 + pubmed:29687724 - a(HBP:"Braak_Stage II") association p(HGNC:MAPT) + path(MESH:"Cognitive Dysfunction") decreases path(MESH:Thinking) - pmid:28176663 + pubmed:29687724 - a(HBP:"Braak_Stage II") positiveCorrelation act(p(HGNC:GSK3B), ma(kin)) + path(MESH:"Cognitive Dysfunction") decreases path(MESH:"Executive Function") - + + + pubmed:29687724 + + path(MESH:"Cognitive Dysfunction") decreases path(MESH:Memory) + - pmid:22908190 + pubmed:24027553 - p(HGNC:RAB5A) positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:"Cognitive Dysfunction") positiveCorrelation path(MESH:Tauopathies) - pmid:22908190 + pubmed:30108137 - p(HGNC:RAB5A) increases complex(a(GO:"early endosome"), a(GO:"late endosome")) + path(MESH:"Cognitive Dysfunction") positiveCorrelation r(HGNC:TFEB) - pmid:22908190 + pubmed:30126037 - p(HGNC:RAB5A) association bp(GO:"regulation of endosome size") + path(MESH:"Cognitive Dysfunction") association p(HGNC:CDKN2A) - pmid:22908190 + pubmed:30126037 - act(p(HGNC:RAB5A)) positiveCorrelation a(MESH:Proteins) + path(MESH:"Cognitive Dysfunction") association bp(MESH:"Cerebrovascular Circulation") - pmid:22908190 + pubmed:19765634 - act(p(HGNC:RAB5A)) positiveCorrelation a(CHEBI:lipid) + path(MESH:"Cognitive Dysfunction") positiveCorrelation g(DBSNP:rs8052688) - pmid:22908190 + pubmed:19765634 - act(p(HGNC:RAB5A)) negativeCorrelation bp(GO:"lysosomal protein catabolic process") + path(MESH:"Cognitive Dysfunction") positiveCorrelation g(DBSNP:rs8063) - pmid:22908190 + pubmed:28669544 - act(p(HGNC:RAB5A)) positiveCorrelation bp(GO:"neuron death") + path(MESH:"Cognitive Dysfunction") positiveCorrelation path(MESH:"Neuronal Plasticity") - pmid:22908190 + pubmed:29196815 - act(p(HGNC:RAB5A)) increases bp(GO:endocytosis) + a(CONSO:CONSO00076) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:22908190 + pubmed:29196815 - act(p(HGNC:RAB5A)) increases bp(GO:endocytosis) + a(CONSO:CONSO00076) biomarkerFor path(MESH:"Alzheimer Disease") - pmid:22908190 + pubmed:18650430 - act(p(HGNC:RAB5A)) decreases bp(GO:endocytosis) + p(HGNC:APP, var("?")) increases path(MESH:"Alzheimer Disease") - pmid:22908190 + pubmed:14556719 - act(p(HGNC:RAB5A)) increases a(CHEBI:"amyloid-beta") + p(HGNC:APP, var("?")) increases path(MESH:"Alzheimer Disease") - pmid:22908190 + pubmed:22908190 - act(p(HGNC:RAB5A)) negativeCorrelation bp(GO:"long-term synaptic potentiation") + p(HGNC:APP, var("?")) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:22908190 + pubmed:22908190 - act(p(HGNC:RAB5A)) negativeCorrelation bp(GO:"long-term synaptic depression") + p(HGNC:APP, var("?")) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:30116051 + pubmed:18650430 - act(p(HGNC:RAB5A)) decreases bp(HP:Neurodegeneration) + p(HGNC:APP, var("?")) increases path(MESH:"Cerebral Amyloid Angiopathy, Familial") - pmid:27607061 + pubmed:29758300 - act(p(HGNC:RAB5A)) negativeCorrelation surf(p(HGNC:GRIK2)) + p(HGNC:APP, var("?")) increases bp(GO:mitophagy) - pmid:27607061 + pubmed:14556719 - act(p(HGNC:RAB5A)) partOf bp(GO:"clathrin-dependent endocytosis") + p(HGNC:APP, var("?")) increases a(CONSO:"amyloid-beta aggregates") + + - pmid:27181519 + pubmed:22908190 - p(HGNC:RAB5A) association g(HGNC:C9orf72) + p(HGNC:APP, var("?")) negativeCorrelation act(a(MESH:Neurites)) - pmid:22908190 + pubmed:28420982 - p(HGNC:RAB4A) positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:"Cerebral Amyloid Angiopathy, Familial") association a(MESH:"Heparan Sulfate Proteoglycans") - pmid:22908190 + pubmed:18650430 - p(HGNC:RAB4A) increases complex(a(GO:"early endosome"), a(GO:"late endosome")) + act(p(HGNC:ADAM17), ma(go:0008233 ! "peptidase activity")) increases rxn(reactants(p(HGNC:APP)), products(p(HGNC:APP, frag("17_*")), p(HGNC:APP, frag("1_16")))) - pmid:22908190 + pubmed:21214928 - p(HGNC:RAB4A) association bp(GO:"regulation of endosome size") + p(HGNC:ADAM17) increases rxn(reactants(p(HGNC:APP)), products(p(CONSO:CONSO00067))) - pmid:22908190 + pubmed:22122372 - p(HGNC:ATP6V0A1, pmod(NGlyco)) increases bp(GO:"pH reduction") + p(HGNC:ADAM17) increases rxn(reactants(p(HGNC:APP)), products(p(CONSO:CONSO00067))) - + + + pubmed:22122372 + + p(HGNC:ADAM17) increases p(CONSO:CONSO00067) + @@ -117861,245 +119197,231 @@

Statements

- pmid:22908190 + pubmed:18650430 - complex(a(GO:endosome), p(HGNC:APP, var("?")), p(HGNC:NAE1)) increases act(p(HGNC:RAB5A)) + act(p(HGNC:ADAM9), ma(go:0008233 ! "peptidase activity")) increases rxn(reactants(p(HGNC:APP)), products(p(HGNC:APP, frag("17_*")), p(HGNC:APP, frag("1_16")))) - - - pmid:22908190 - - a(CHEBI:"low-density lipoprotein cholesterol") positiveCorrelation p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") - - - pmid:22908190 + pubmed:22122372 - a(CHEBI:"low-density lipoprotein cholesterol") positiveCorrelation p(HBP:"APP C-terminally truncated carboxyl-terminal fragments") + p(HGNC:ADAM9) increases rxn(reactants(p(HGNC:APP)), products(p(CONSO:CONSO00067))) - pmid:22908190 + pubmed:22122372 - a(CHEBI:"low-density lipoprotein cholesterol") positiveCorrelation tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:cytosol), toLoc(GO:lysosome)) + p(HGNC:ADAM9) increases p(CONSO:CONSO00067) - pmid:22908190 + pubmed:18650430 - bp(GO:"response to acidic pH") increases a(HBP:"amyloid-beta oligomers") + act(p(HGNC:ADAM10), ma(go:0008233 ! "peptidase activity")) increases rxn(reactants(p(HGNC:APP)), products(p(HGNC:APP, frag("17_*")), p(HGNC:APP, frag("1_16")))) - pmid:30116051 + pubmed:21214928 - p(HGNC:MAPT, frag("?")) decreases bp(GO:"chaperone-mediated autophagy") + p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(p(HGNC:APP, frag("17_*")), p(HGNC:APP, frag("1_16")))) - pmid:26631930 + pubmed:21214928 - p(HGNC:MAPT, frag("?")) increases a(HBP:"Tau aggregates") + p(HGNC:ADAM10) increases p(CONSO:CONSO00067) - pmid:26631930 + pubmed:22122372 - p(HGNC:MAPT, frag("?")) increases a(HBP:"Tau aggregates") + p(HGNC:ADAM10) increases p(CONSO:CONSO00067) - pmid:26631930 + pubmed:21214928 - p(HGNC:MAPT, frag("?")) increases a(HBP:"Tau aggregates") + p(HGNC:ADAM10) decreases a(CHEBI:amyloid-beta) - pmid:26631930 + pubmed:21214928 - p(HGNC:MAPT, frag("?")) increases path(HBP:Neurodegeneration) + p(HGNC:ADAM10) decreases a(CHEBI:amyloid-beta) - pmid:29626319 + pubmed:22122372 - p(HGNC:MAPT, frag("?")) increases bp(HBP:neurotoxicity) + p(HGNC:ADAM10) decreases a(CHEBI:amyloid-beta) - pmid:22908190 + pubmed:21214928 - p(HGNC:RIN1) increases act(p(HGNC:RAB5A)) + p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(p(CONSO:CONSO00067))) - pmid:22908190 + pubmed:21214928 - p(HGNC:RIN1) decreases bp(GO:"long-term synaptic potentiation") + p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(p(CONSO:CONSO00067))) - pmid:22908190 + pubmed:22122372 - p(HGNC:RIN1) decreases bp(GO:"fear response") + p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(p(CONSO:CONSO00067))) - pmid:22908190 + pubmed:22122372 - p(HGNC:RIN1) decreases bp(GO:memory) + p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(p(CONSO:CONSO00067))) - pmid:22908190 + pubmed:21214928 - p(HGNC:RIN1) decreases a(MESH:"Receptors, AMPA") + p(HGNC:ADAM10) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:22908190 + pubmed:21214928 - sec(a(MESH:Hydrolases)) increases path(MESH:Necrosis) + act(p(HGNC:ADAM10)) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:22908190 + pubmed:22122372 - p(HGNC:CST3) decreases act(a(GO:synapse)) + p(HGNC:ADAM10) increases tloc(p(HGNC:APP), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:24563850 + pubmed:24590577 - a(MESH:"Heat-Shock Proteins") regulates bp(GO:"response to oxidative stress") + p(HGNC:ADAM10) increases deg(p(HGNC:APP)) - pmid:21882945 + pubmed:22122372 - a(MESH:"Heat-Shock Proteins") increases bp(GO:"proteasomal protein catabolic process") + p(HGNC:ADAM10) increases rxn(reactants(p(HGNC:APP)), products(p(CONSO:CONSO00067), p(CONSO:CONSO00072))) - pmid:21882945 + pubmed:22122372 - a(MESH:"Heat-Shock Proteins") increases bp(GO:autophagy) + p(HGNC:ADAM10) decreases path(MESH:"Plaque, Amyloid") - pmid:23746257 + pubmed:28499950 - act(p(HGNCGENEFAMILY:Chaperonins)) association bp(GO:"'de novo' protein folding") + act(p(HGNC:ADAM10)) directlyIncreases rxn(reactants(p(HGNC:MAPT)), products(p(HGNC:MAPT, frag("421_*")))) - pmid:23746257 + pubmed:24590577 - act(p(HGNCGENEFAMILY:Chaperonins)) association bp(GO:"protein refolding") + p(HGNC:ADAM10) increases p(CONSO:sAPP-alpha) - pmid:23746257 + pubmed:18650430 - bp(GO:"protein refolding") association act(p(HGNCGENEFAMILY:Chaperonins)) + act(p(HGNC:BACE2), ma(go:0008233 ! "peptidase activity")) increases rxn(reactants(p(HGNC:APP)), products(p(HGNC:APP, frag("17_*")), p(HGNC:APP, frag("1_16")))) - pmid:23746257 + pubmed:21214928 - bp(GO:"protein refolding") association act(p(FPLX:HSPA)) + p(HGNC:BACE2) association rxn(reactants(p(HGNC:APP)), products(a(CHEBI:amyloid-beta))) - pmid:23746257 + pubmed:21214928 - bp(GO:"protein refolding") association act(p(FPLX:HSPA)) + p(HGNC:BACE2) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:amyloid-beta))) - - - pmid:23746257 - - bp(GO:"protein refolding") association act(p(FPLX:HSP90)) - - @@ -118108,69 +119430,63 @@

Statements

- pmid:23746257 + pubmed:18650430 - complex(p(FPLX:"CCT_complex"), p(FPLX:HSPA)) increases bp(GO:"'de novo' protein folding") + complex(FPLX:"Gamma_secretase") increases a(MESH:"Amyloid beta-Peptides") - pmid:23746257 + pubmed:18650430 - bp(GO:"steroid hormone mediated signaling pathway") association p(FPLX:HSP90) + complex(FPLX:"Gamma_secretase") increases p(CONSO:CONSO00071) - pmid:23746257 + pubmed:22122372 - bp(GO:"protein secretion") association p(FPLX:HSP90) + complex(FPLX:"Gamma_secretase") increases p(CONSO:CONSO00071) - pmid:23746257 + pubmed:21214928 - bp(GO:"intracellular protein transmembrane transport") association act(p(FPLX:HSPA)) + complex(FPLX:"Gamma_secretase") increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:amyloid-beta))) - pmid:23746257 + pubmed:22122372 - p(FPLX:RAPGEF) regulates act(p(FPLX:HSPA)) + complex(FPLX:"Gamma_secretase") increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:amyloid-beta))) - - - - - - - pmid:23746257 + pubmed:21722302 - composite(p(FPLX:HSPA), p(HGNC:HSPH1), p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins")) decreases a(MESH:"Protein Aggregates") + complex(FPLX:"Gamma_secretase") increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:amyloid-beta))) - pmid:21882945 + pubmed:21214928 - p(HGNC:HSPH1) decreases p(HGNC:MAPT, pmod(Ph)) + complex(FPLX:"Gamma_secretase") increases rxn(reactants(p(CONSO:CONSO00024)), products(a(CHEBI:amyloid-beta), p(CONSO:CONSO00072))) @@ -118181,618 +119497,645 @@

Statements

- pmid:23746257 + pubmed:21214928 - complex(p(HGNC:HSPD1), p(HGNC:HSPE1)) increases bp(GO:"protein refolding") + complex(FPLX:"Gamma_secretase") increases p(CONSO:CONSO00024, frag("?")) - - - - - pmid:23746257 + pubmed:21214928 - complex(a(CHEBI:ATP), p(HGNC:HSPD1)) increases complex(p(HGNC:HSPD1), p(HGNC:HSPE1)) + complex(FPLX:"Gamma_secretase") increases p(HGNC:NOTCH1, frag("?")) - - - - - pmid:23746257 + pubmed:21214928 - complex(a(CHEBI:ATP), p(FPLX:HSP90)) regulates act(p(FPLX:HSP90)) + complex(FPLX:"Gamma_secretase") increases p(FPLX:Cadherin, frag("?")) - pmid:29311797 + pubmed:21214928 - complex(a(CHEBI:ATP), p(FPLX:HSP90)) increases bp(MESH:Proteolysis) + complex(FPLX:"Gamma_secretase") increases p(HGNC:TYR, frag("?")) - pmid:29311797 + pubmed:21214928 - complex(a(CHEBI:ATP), p(FPLX:HSP90)) increases bp(GO:"protein folding") + complex(FPLX:"Gamma_secretase") increases p(HGNC:ERBB4, frag("?")) - pmid:29311797 + pubmed:21214928 - complex(a(CHEBI:ATP), p(FPLX:HSP90)) decreases path(MESH:"Protein Aggregation, Pathological") + complex(FPLX:"Gamma_secretase") increases p(HGNC:CD44, frag("?")) - pmid:29311797 + pubmed:22122372 - complex(a(CHEBI:ATP), p(FPLX:HSP90)) increases bp(GO:"protein modification process") + complex(FPLX:"Gamma_secretase") increases rxn(reactants(p(CONSO:CONSO00072)), products(p(CONSO:CONSO00071), p(CONSO:CONSO00080))) - pmid:23746257 + pubmed:22122372 - bp(GO:"ATP metabolic process") increases act(p(FPLX:HSP90)) + complex(FPLX:"Gamma_secretase") increases rxn(reactants(p(CONSO:CONSO00081)), products(a(MESH:"Amyloid beta-Peptides"), p(CONSO:CONSO00071))) - pmid:25784053 + pubmed:22122372 - bp(GO:"ATP metabolic process") increases act(p(FPLX:HSP90)) + complex(FPLX:"Gamma_secretase") increases p(HGNC:APP, frag("1_38")) - pmid:29311797 + pubmed:22122372 - bp(GO:"ATP metabolic process") increases act(p(FPLX:HSP90)) + complex(FPLX:"Gamma_secretase") increases p(HGNC:APP, frag("1_43")) - pmid:25784053 + pubmed:22122372 - bp(GO:"ATP metabolic process") increases act(p(FPLX:HSPA)) + complex(FPLX:"Gamma_secretase") increases p(HGNC:APP, frag("672_711")) - pmid:23746257 + pubmed:21722302 - p(HGNC:CDC37) decreases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) + complex(FPLX:"Gamma_secretase") increases p(HGNC:APP, frag("672_711")) - pmid:21882945 + pubmed:24590577 - p(HGNC:CDC37) regulates act(p(FPLX:HSP90)) + complex(FPLX:"Gamma_secretase") increases deg(p(CONSO:C99)) - pmid:21367866 + pubmed:24590577 - p(HGNC:CDC37) positiveCorrelation act(p(FPLX:HSP90)) + complex(FPLX:"Gamma_secretase") increases a(CHEBI:amyloid-beta) - pmid:25036637 + pubmed:29626319 - p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(INTERPRO:"Heat shock protein Hsp90 family")) + complex(FPLX:"Gamma_secretase") increases a(CHEBI:amyloid-beta) - pmid:25036637 + pubmed:24590577 - p(HGNC:CDC37) directlyIncreases complex(p(HGNC:AHSA1), p(HGNC:CDC37)) + complex(FPLX:"Gamma_secretase") increases p(CONSO:AICD) - pmid:25036637 + pubmed:21722302 - p(HGNC:CDC37) directlyIncreases complex(p(HGNC:AURKB), p(HGNC:CDC37)) + complex(FPLX:"Gamma_secretase") increases p(HGNC:APP, frag("672_713")) - pmid:25036637 + pubmed:21722302 - p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:CDK11A)) + complex(FPLX:"Gamma_secretase") negativeCorrelation p(HGNC:UBQLN1) - - - pmid:25036637 - - p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:CDK1)) - + - pmid:25036637 + pubmed:26968346 - p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:IKBKG)) + p(HGNC:PSEN2) positiveCorrelation bp(GO:"autophagosome-lysosome fusion") - pmid:25036637 + pubmed:26968346 - p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:CDK4)) + p(HGNC:PSEN2) positiveCorrelation bp(GO:"endomembrane system organization") - pmid:25036637 + pubmed:26968346 - p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:FER)) + p(HGNC:PSEN2) positiveCorrelation bp(GO:"sequestering of calcium ion") - - - pmid:25036637 - - p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:CHUK)) - + - - - pmid:25036637 - - p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:RAF1)) - + - pmid:25036637 + pubmed:21718217 - p(HGNC:CDC37) directlyIncreases complex(p(HGNC:ABL2), p(HGNC:CDC37)) + p(HGNC:APH1A) decreases p(HGNC:APP) - pmid:25036637 + pubmed:21718217 - p(HGNC:CDC37) directlyIncreases complex(p(HGNC:ARAF), p(HGNC:CDC37)) + p(HGNC:APH1A) increases a(CHEBI:"amyloid-beta polypeptide 42") - - - pmid:25036637 - - p(HGNC:CDC37) association p(HGNC:FKBP5) - + - pmid:25036637 + pubmed:18650430 - p(HGNC:CDC37) directlyIncreases complex(a(MESH:"Protein Kinases"), p(HGNC:CDC37)) + p(HGNC:APBA1) decreases a(CHEBI:amyloid-beta) - pmid:21882945 + pubmed:18650430 - p(HGNC:CDC37) increases complex(a(MESH:"Protein Kinases"), p(FPLX:HSP90)) + p(HGNC:APBA1) decreases a(CONSO:CONSO00018) - pmid:29311797 + pubmed:18650430 - p(HGNC:CDC37) increases p(HGNC:MAPT) + p(HGNC:APBA1) regulates bp(CONSO:CONSO00073) + + + + - pmid:21367866 + pubmed:21214928 - p(HGNC:CDC37) decreases deg(p(HGNC:MAPT)) + bp(CONSO:CONSO00073) association p(HGNC:RAB6A) - pmid:21367866 + pubmed:22122372 - p(HGNC:CDC37) isA complex(p(FPLX:HSP90), p(HGNC:CDC37)) + bp(CONSO:CONSO00073) association p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Thr, 654)) - pmid:21367866 + pubmed:22122372 - p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 231)) + bp(CONSO:CONSO00073) association p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Thr, 668)) - pmid:21367866 + pubmed:22122372 - p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 199)) + bp(CONSO:CONSO00073) association p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Ser, 665)) - pmid:21367866 + pubmed:22122372 - p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) + bp(CONSO:CONSO00073) association complex(p(CONSO:CONSO00071), p(HGNC:MAPK8IP1)) - pmid:21367866 + pubmed:18650430 - p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) + p(HGNC:APBA2) decreases a(CHEBI:amyloid-beta) - pmid:21367866 + pubmed:18650430 - p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 404)) + p(HGNC:APBA2) decreases a(CONSO:CONSO00018) - pmid:21367866 + pubmed:18650430 - p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) + p(HGNC:APBA2) regulates bp(CONSO:CONSO00073) + + - pmid:21367866 + pubmed:18650430 - p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 356)) + p(HGNC:APBB1) decreases a(CHEBI:amyloid-beta) - pmid:21367866 + pubmed:18650430 - p(HGNC:CDC37) positiveCorrelation act(p(HGNC:CDK5)) + p(HGNC:APBB1) decreases a(CONSO:CONSO00018) - pmid:21367866 + pubmed:18650430 - p(HGNC:CDC37) causesNoChange p(HGNC:GSK3B) + p(HGNC:APBB1) regulates bp(CONSO:CONSO00073) - pmid:21367866 + pubmed:18650430 - p(HGNC:CDC37) causesNoChange p(HGNC:MARK2) + p(HGNC:APBB1) increases p(CONSO:CONSO00071) + + + + + + + + + + + + + + - pmid:23746257 + pubmed:21034527 - p(HGNC:AHSA1) increases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) + p(HGNC:APBB1) association act(p(HGNC:SP1), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) - pmid:21882945 + pubmed:21214928 - p(HGNC:AHSA1) regulates act(p(FPLX:HSP90)) + act(p(CONSO:CONSO00071), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) regulates p(HGNC:APP) - pmid:29311797 + pubmed:21214928 - p(HGNC:AHSA1) increases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) + act(p(CONSO:CONSO00071), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) regulates p(HGNC:GSK3B) - pmid:21882945 + pubmed:21214928 - p(HGNC:AHSA1) increases rxn(reactants(a(CHEBI:ATP)), products(a(CHEBI:"phosphate(3-)"), a(CHEBI:ADP))) + act(p(CONSO:CONSO00071), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) regulates p(HGNC:CD82) - pmid:21882945 + pubmed:21214928 - p(HGNC:AHSA1) increases complex(a(CHEBI:polypeptide), p(HGNC:STUB1)) + act(p(CONSO:CONSO00071), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) regulates p(HGNC:MME) - pmid:29311797 + pubmed:21214928 - p(HGNC:AHSA1) positiveCorrelation path(MESH:"Alzheimer Disease") + act(p(CONSO:CONSO00071), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) regulates p(HGNC:BACE1) - pmid:29311797 + pubmed:21214928 - p(HGNC:AHSA1) increases a(HBP:"Tau aggregates") + act(p(CONSO:CONSO00071), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) regulates p(HGNC:EGFR) - pmid:29311797 + pubmed:21214928 - p(HGNC:AHSA1) association path(MESH:"Cystic Fibrosis") + act(p(CONSO:CONSO00071), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) regulates p(HGNC:LRP1) - pmid:23746257 + pubmed:21214928 - bp(GO:"behavioral response to starvation") association bp(HBP:Proteostasis) + p(CONSO:CONSO00071) increases bp(GO:"apoptotic process") + + + + + + + + + + + + + + + + + + - pmid:23746257 + pubmed:22122372 - p(FPLX:Proteasome) increases bp(GO:"protein catabolic process") + act(p(CONSO:CONSO00071)) association p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Thr, 654)) + + - pmid:26195256 + pubmed:22122372 - act(p(FPLX:Proteasome)) increases bp(GO:"protein catabolic process") + act(p(CONSO:CONSO00071)) association p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Thr, 668)) + + - pmid:23746257 + pubmed:22122372 - p(FPLX:Proteasome) increases bp(GO:"protein unfolding") + act(p(CONSO:CONSO00071)) association p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Ser, 665)) + + + + - pmid:25784053 + pubmed:22122372 - p(FPLX:Proteasome) increases bp(MESH:Proteolysis) + p(CONSO:CONSO00071) increases bp(GO:"cell death") + + - pmid:25784053 + pubmed:22122372 - p(FPLX:Proteasome) decreases path(MESH:"Protein Aggregation, Pathological") + p(CONSO:CONSO00071) increases p(HGNC:TP53) - pmid:25784053 + pubmed:22122372 - act(p(FPLX:Proteasome)) negativeCorrelation path(MESH:"Alzheimer Disease") + p(CONSO:CONSO00071) increases act(p(HGNC:TP53)) + + - pmid:30145931 + pubmed:22122372 - act(p(FPLX:Proteasome)) decreases path(HBP:neurotoxicity) + p(CONSO:CONSO00071) regulates bp(GO:"calcium ion homeostasis") - pmid:30145931 + pubmed:18650430 - act(p(FPLX:Proteasome)) decreases p(HGNC:MAPT) + p(HGNC:SORL1) decreases a(CHEBI:amyloid-beta) - pmid:30145931 + pubmed:21214928 - act(p(FPLX:Proteasome)) increases deg(p(HGNC:MAPT, loc(MESH:Dendrites))) + p(HGNC:SORL1) decreases a(CHEBI:amyloid-beta) - pmid:26195256 + pubmed:29758300 - act(p(FPLX:Proteasome)) increases deg(p(HGNC:MAPT)) + p(HGNC:SORL1) negativeCorrelation a(CHEBI:amyloid-beta) - pmid:30145931 + pubmed:26996954 - act(p(FPLX:Proteasome)) increases deg(p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356))) + p(HGNC:SORL1) association p(HGNC:APP) - pmid:29311797 + pubmed:26996954 - act(p(FPLX:Proteasome)) negativeCorrelation path(MESH:"Neurodegenerative Diseases") + p(HGNC:SORL1) decreases p(HGNC:APP) - pmid:26195256 + pubmed:26996954 - act(p(FPLX:Proteasome)) increases deg(a(CHEBI:"amyloid-beta", loc(GO:intracellular))) + p(HGNC:SORL1) association g(DBSNP:rs3824968) - pmid:22941973 + pubmed:26996954 - act(p(FPLX:Proteasome)) increases deg(p(RGD:Syp)) + p(HGNC:SORL1) association a(NIFT:"Grey matter volume") - pmid:25546293 + pubmed:26996954 - act(p(FPLX:Proteasome)) increases deg(p(HGNC:CTNNB1, pmod(Ub))) + p(HGNC:SORL1) increases p(HGNC:APP, frag("672_713")) + + - pmid:24964035 + pubmed:29758300 - act(p(FPLX:Proteasome)) increases deg(p(HGNC:SMAD2)) + p(HGNC:SORL1) association path(MESH:"Alzheimer Disease") - - - + + + pubmed:18650430 + + composite(p(HGNC:APP), p(HGNC:CNTN2)) decreases bp(GO:neurogenesis) + @@ -118802,267 +120145,281 @@

Statements

- pmid:23746257 + pubmed:26813123 - composite(p(FPLX:HSP90), p(FPLX:HSPA), p(HGNC:BAG1), p(HGNC:BAG3), p(HGNC:STUB1)) increases bp(GO:"protein ubiquitination") + p(HGNC:SLC5A7) increases tloc(a(CHEBI:choline), fromLoc(GO:"synaptic cleft"), toLoc(MESH:"Cholinergic Neurons")) - pmid:23746257 + pubmed:26813123 - p(HGNC:BAG1) increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + p(HGNC:SLC5A7) increases tloc(a(CHEBI:choline), fromLoc(GO:"synaptic cleft"), toLoc(MESH:"Cholinergic Neurons")) - pmid:25036637 + pubmed:26813123 - p(HGNC:BAG1) increases complex(p(HGNC:BAG1), p(HGNC:LTN1)) + p(HGNC:SLC5A7) increases a(CHEBI:choline) - pmid:25036637 + pubmed:26813123 - p(HGNC:BAG1) directlyIncreases complex(p(HGNC:BAG1), p(HGNC:PSMA5)) + p(HGNC:SLC5A7) increases tloc(a(CHEBI:choline), fromLoc(GO:"synaptic cleft"), toLoc(MESH:"Cholinergic Neurons")) - pmid:25036637 + pubmed:26813123 - p(HGNC:BAG1) directlyIncreases complex(p(HGNC:BAG1), p(HGNC:PSMC4)) + p(HGNC:SLC5A7) increases a(CHEBI:acetylcholine) + + - pmid:25036637 + pubmed:17293005 - p(HGNC:BAG1) directlyIncreases complex(p(HGNC:BAG1), p(HGNC:PSMD2)) + p(HGNC:BACE1, frag("67_78")) decreases tloc(p(CONSO:sAPP-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:21882945 + pubmed:17293005 - p(HGNC:BAG1) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:BACE1, frag("67_78")) decreases p(CONSO:sAPP-beta) - pmid:21882945 + pubmed:17293005 - p(HGNC:BAG1) directlyIncreases complex(p(HGNC:BAG1), p(HGNC:MAPT)) + p(HGNC:BACE1, frag("67_78")) decreases tloc(p(CONSO:sAPP-alpha), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:21882945 + pubmed:17293005 - p(HGNC:BAG1) decreases deg(p(HGNC:MAPT)) + p(HGNC:BACE1, frag("67_78")) increases p(CONSO:sAPP-alpha, loc(GO:intracellular)) - pmid:17954934 + pubmed:17293005 - p(HGNC:BAG1) positiveCorrelation p(HGNC:MAPT) + p(HGNC:BACE1, frag("67_78")) increases p(CONSO:sAPP-alpha) - pmid:17954934 + pubmed:17293005 - p(HGNC:BAG1) decreases deg(p(HGNC:MAPT)) + p(HGNC:BACE1, frag("67_78")) causesNoChange a(CHEBI:amyloid-beta) - pmid:17954934 + pubmed:17293005 - p(HGNC:BAG1) isA complex(p(HGNC:BAG1), p(HGNC:MAPT), p(HGNC:STUB1)) + p(HGNC:BACE1, frag("67_78")) causesNoChange p(HGNC:ACTB) - pmid:17954934 + pubmed:17293005 - p(HGNC:BAG1) negativeCorrelation act(complex(GO:"proteasome complex")) + p(HGNC:BACE1, frag("67_78")) causesNoChange act(p(HGNC:BACE1)) - pmid:17954934 + pubmed:17293005 - p(HGNC:BAG1) negativeCorrelation p(HGNC:MAPT, pmod(Ph)) + p(HGNC:BACE1, frag("67_78")) decreases a(CHEBI:"amyloid-beta polypeptide 40") - pmid:23746257 + pubmed:17293005 - a(CHEBI:Guanabenz) decreases act(p(FPLX:ADRA2)) + p(HGNC:BACE1, frag("69_75")) causesNoChange tloc(p(CONSO:sAPP-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:23746257 + pubmed:17293005 - a(CHEBI:Guanabenz) decreases act(p(FPLX:EIF2B)) + p(HGNC:BACE1, frag("69_75")) causesNoChange tloc(p(CONSO:sAPP-alpha), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:23746257 + pubmed:17293005 - a(CHEBI:Guanabenz) increases p(FPLX:EIF2B, pmod(Ph)) + p(HGNC:BACE1, frag("69_75")) causesNoChange a(CHEBI:amyloid-beta) + + + pubmed:17293005 + + p(HGNC:BACE1, frag("69_75")) causesNoChange p(HGNC:ACTB) + + - pmid:23746257 + pubmed:17293005 - p(FPLX:EIF2B, pmod(Ph)) decreases act(p(FPLX:EIF2B)) + p(HGNC:BACE1, frag("228_236")) decreases tloc(p(CONSO:sAPP-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:23746257 + pubmed:17293005 - a(CHEBI:geldanamycin) increases act(p(HGNC:HSF1)) + p(HGNC:BACE1, frag("228_236")) decreases p(CONSO:sAPP-beta) - pmid:25784053 + pubmed:17293005 - a(CHEBI:geldanamycin) decreases act(p(FPLX:HSP90)) + p(HGNC:BACE1, frag("228_236")) decreases tloc(p(CONSO:sAPP-alpha), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:30116051 + pubmed:17293005 - a(CHEBI:geldanamycin) decreases act(p(FPLX:HSP90)) + p(HGNC:BACE1, frag("228_236")) increases p(CONSO:sAPP-alpha, loc(GO:intracellular)) - pmid:21882945 + pubmed:17293005 - a(CHEBI:geldanamycin) decreases act(p(FPLX:HSP90)) + p(HGNC:BACE1, frag("228_236")) increases p(CONSO:sAPP-alpha) - pmid:21882945 + pubmed:17293005 - a(CHEBI:geldanamycin) decreases act(p(FPLX:HSP90)) + p(HGNC:BACE1, frag("228_236")) causesNoChange a(CHEBI:amyloid-beta) - pmid:30116051 + pubmed:17293005 - a(CHEBI:geldanamycin) decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + p(HGNC:BACE1, frag("228_236")) causesNoChange p(HGNC:ACTB) - pmid:30116051 + pubmed:17293005 - a(CHEBI:geldanamycin) decreases a(HBP:"alpha-synuclein oligomers") + p(HGNC:BACE1, frag("228_236")) causesNoChange act(p(HGNC:BACE1)) - pmid:24027553 + pubmed:17293005 - a(CHEBI:geldanamycin) increases act(p(HGNCGENEFAMILY:Proteasome)) + p(HGNC:BACE1, frag("228_236")) decreases a(CHEBI:"amyloid-beta polypeptide 40") - pmid:21882945 + pubmed:17293005 - a(CHEBI:geldanamycin) decreases complex(p(FPLX:HSP90), p(HGNC:PTGES3)) + p(HGNC:BACE1, frag("230_235")) causesNoChange tloc(p(CONSO:sAPP-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - + + + pubmed:17293005 + + p(HGNC:BACE1, frag("230_235")) causesNoChange tloc(p(CONSO:sAPP-alpha), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + - pmid:23746257 + pubmed:17293005 - composite(p(FPLX:"CCT_complex"), p(FPLX:HSPA)) decreases a(MESH:"Protein Aggregates") + p(HGNC:BACE1, frag("230_235")) causesNoChange a(CHEBI:amyloid-beta) - pmid:23746257 + pubmed:17293005 - composite(p(FPLX:"CCT_complex"), p(FPLX:HSPA)) decreases a(HBP:"huntingtin aggregates") + p(HGNC:BACE1, frag("230_235")) causesNoChange p(HGNC:ACTB) @@ -119073,596 +120430,626 @@

Statements

- pmid:24457024 + pubmed:21214928 - complex(a(CHEBI:ATP), p(HGNC:UBA1)) increases act(a(MESH:Ubiquitin)) + rxn(reactants(p(HGNC:APP)), products(a(CHEBI:amyloid-beta))) association p(HGNC:BACE2) - pmid:24457024 + pubmed:21214928 - complex(a(CHEBI:ATP), p(HGNC:UBA1)) increases act(a(MESH:Ubiquitin)) + a(MESH:"Amyloid Precursor Protein Secretases") increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:amyloid-beta))) - pmid:24457024 + pubmed:26813123 - p(HGNC:UBE2K) increases complex(a(MESH:Ubiquitin), p(HGNC:UBE2K)) + a(MESH:"Amyloid Precursor Protein Secretases") decreases a(MESH:"Amyloid beta-Peptides") - - - - - - - - - pmid:24457024 + pubmed:14556719 - p(HGNC:UBE2S) increases complex(a(MESH:Ubiquitin), p(HGNC:UBE2S)) + a(MESH:"Amyloid Precursor Protein Secretases") increases rxn(reactants(p(HGNC:APP)), products(a(MESH:"Amyloid beta-Peptides"))) - - - - - pmid:24457024 + pubmed:21214928 - path(MESH:"RING Finger Domains") increases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) + p(CONSO:CONSO00067) decreases path(CONSO:CONSO00061) - pmid:24457024 + pubmed:22122372 - p(INTERPRO:"U box domain") increases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) + p(CONSO:CONSO00067) decreases path(CONSO:CONSO00061) - - - - - pmid:24457024 + pubmed:22122372 - complex(a(MESH:Ubiquitin), p(MESH:Proteins, pmod(HBP:misfolding))) increases deg(p(MESH:Proteins, pmod(HBP:misfolding))) + tloc(p(CONSO:CONSO00067), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) decreases path(CONSO:CONSO00061) - pmid:24457024 + pubmed:21214928 - p(HGNC:BAG6) increases complex(p(HGNC:BAG6), p(MESH:Proteins, pmod(HBP:misfolding))) + p(CONSO:CONSO00067) negativeCorrelation path(MESH:"Alzheimer Disease") - + + + pubmed:21214928 + + p(CONSO:CONSO00067) association bp(GO:"regulation of neuronal synaptic plasticity") + - pmid:24457024 + pubmed:21214928 - complex(p(HGNC:BAG6), p(MESH:Proteins, pmod(HBP:misfolding))) association bp(GO:"ERAD pathway") + p(CONSO:CONSO00067) regulates bp(GO:"central nervous system formation") - + + + pubmed:21214928 + + p(CONSO:CONSO00067) decreases path(CONSO:CONSO00068) + - pmid:24457024 + pubmed:21214928 - complex(p(HGNC:BAG6), p(HGNC:UBA3)) increases deg(p(MESH:Proteins, pmod(HBP:misfolding))) + p(CONSO:CONSO00067) decreases path(CONSO:CONSO00068) - pmid:24457024 + pubmed:21214928 - complex(p(HGNC:BAG6), p(HGNC:UBA3)) increases bp(GO:"protein ubiquitination") + p(CONSO:CONSO00067) regulates bp(GO:"stem cell proliferation") - pmid:24457024 + pubmed:21214928 - complex(p(HGNC:BAG6), p(HGNC:UBA3)) decreases bp(HBP:"protein aggregation") + p(CONSO:CONSO00067) decreases act(p(HGNC:CDK5)) - + + + pubmed:21214928 + + p(CONSO:CONSO00067) association complex(p(HGNC:APBA1), p(HGNC:APP)) + - pmid:24457024 + pubmed:21214928 - complex(a(GO:"proteasome complex"), p(HGNC:BAG6)) increases deg(p(MESH:Proteins, pmod(HBP:misfolding))) + tloc(p(CONSO:CONSO00067), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association complex(p(HGNC:APBA1), p(HGNC:APP)) - pmid:24457024 + pubmed:21214928 - complex(a(GO:"proteasome complex"), p(HGNC:BAG6)) decreases bp(HBP:"protein aggregation") + p(CONSO:CONSO00067) association complex(p(HGNC:APBA2), p(HGNC:APP)) - pmid:24457024 + pubmed:21214928 - complex(a(GO:"proteasome complex"), p(HGNC:BAG6)) increases bp(GO:"protein ubiquitination") + tloc(p(CONSO:CONSO00067), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association complex(p(HGNC:APBA2), p(HGNC:APP)) - pmid:24457024 + pubmed:21214928 - a(MESH:"Deubiquitinating Enzymes") decreases complex(a(MESH:Proteins), a(MESH:Ubiquitin)) + p(CONSO:CONSO00067) association complex(p(HGNC:APBA3), p(HGNC:APP)) - + + + pubmed:21214928 + + tloc(p(CONSO:CONSO00067), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association complex(p(HGNC:APBA3), p(HGNC:APP)) + - pmid:24457024 + pubmed:21214928 - complex(a(GO:"proteasome complex"), p(HGNC:UCHL5)) increases bp(GO:"protein catabolic process") + tloc(p(CONSO:CONSO00067), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association a(CHEBI:"phorbol ester") - + + + pubmed:22122372 + + p(CONSO:CONSO00067) increases bp(GO:"cell adhesion") + - pmid:24457024 + pubmed:22122372 - complex(a(GO:"proteasome complex"), p(HGNC:USP14)) increases bp(GO:"protein catabolic process") + p(CONSO:CONSO00067) increases bp(MESH:"Neuronal Outgrowth") - pmid:24457024 + pubmed:22122372 - complex(a(GO:"proteasome complex"), p(HGNC:USP14)) decreases bp(GO:"protein catabolic process") + p(CONSO:CONSO00067) increases bp(GO:"synapse assembly") - pmid:25784053 + pubmed:22122372 - p(HGNC:USP14) decreases deg(p(HGNC:MAPT)) + p(CONSO:CONSO00067) increases bp(GO:learning) - pmid:25784053 + pubmed:22122372 - p(HGNC:USP14) decreases deg(p(HGNC:TARDBP)) + p(CONSO:CONSO00067) increases bp(GO:memory) - pmid:25784053 + pubmed:21214928 - p(HGNC:USP14) decreases act(p(FPLX:Proteasome)) + bp(CONSO:CONSO00077) increases p(CONSO:CONSO00063) - pmid:26041011 + pubmed:22122372 - act(p(HGNC:USP14)) decreases act(complex(GO:"proteasome complex")) + bp(CONSO:CONSO00077) increases p(CONSO:CONSO00063) - pmid:24457024 + pubmed:21214928 - act(p(HGNC:USP6)) decreases path(MESH:Aneuploidy) + bp(CONSO:CONSO00077) increases p(CONSO:CONSO00064) - + + + pubmed:22122372 + + bp(CONSO:CONSO00077) increases p(CONSO:CONSO00064) + - pmid:24457024 + pubmed:21214928 - p(HGNC:ADRM1) increases complex(a(GO:"proteasome complex"), p(MESH:Proteins, pmod(Ub))) + bp(CONSO:CONSO00077) increases p(CONSO:CONSO00065) - pmid:25036637 + pubmed:21214928 - p(HGNC:ADRM1) directlyIncreases complex(p(HGNC:ADRM1), p(HGNC:PSMA5)) + p(CONSO:CONSO00064) association p(UNIPROT:A0A293M1A7) - pmid:25036637 + pubmed:21214928 - p(HGNC:ADRM1) directlyIncreases complex(p(HGNC:ADRM1), p(HGNC:PSMC1)) + p(CONSO:CONSO00064) increases path(MESH:"Plaque, Amyloid") - pmid:25036637 + pubmed:22122372 - p(HGNC:ADRM1) directlyIncreases complex(p(HGNC:ADRM1), p(HGNC:PSMD1)) + p(CONSO:CONSO00064) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:25036637 + pubmed:21214928 - p(HGNC:ADRM1) directlyIncreases complex(p(HGNC:ADRM1), p(HGNC:PSMD4)) + p(CONSO:CONSO00065) association p(UNIPROT:A0A293M1A7) - pmid:24457024 + pubmed:21214928 - p(HGNC:PSMD14) decreases complex(a(MESH:Proteins), a(MESH:Ubiquitin)) + p(CONSO:CONSO00065) increases path(MESH:"Plaque, Amyloid") - pmid:24457024 + pubmed:21214928 - p(HGNC:PSMD14) decreases complex(a(MESH:Proteins), a(MESH:Ubiquitin)) + p(CONSO:CONSO00065) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:24457024 + pubmed:22122372 - act(p(HGNC:PSMD14)) increases tloc(a(MESH:Proteins), fromLoc(GO:cytosol), toLoc(HBP:"20 S Proteasome")) + p(CONSO:CONSO00065) positiveCorrelation path(MESH:"Alzheimer Disease") - + + + pubmed:21214928 + + p(UNIPROT:A0A293M1A7) association p(CONSO:CONSO00064) + - pmid:24457024 + pubmed:21214928 - complex(a(GO:"proteasome complex"), a(MESH:Proteins)) increases tloc(a(MESH:Proteins), fromLoc(GO:cytosol), toLoc(HBP:"20 S Proteasome")) + p(UNIPROT:A0A293M1A7) association p(CONSO:CONSO00065) - pmid:25784053 + pubmed:21214928 - bp(MESH:"Protein Biosynthesis") association bp(HBP:Proteostasis) + r(CONSO:CONSO00064) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:25784053 + pubmed:21214928 - bp(MESH:Proteolysis) association bp(HBP:Proteostasis) + bp(GO:"signal transduction") association p(HGNC:APP) - pmid:29311797 + pubmed:17403556 - bp(MESH:Proteolysis) association a(MESH:"Molecular Chaperones") + bp(GO:"signal transduction") increases complex(a(CONSO:"amyloid-beta derived diffusible ligands"), p(HGNC:MAPT)) - pmid:25784053 + pubmed:29311797 - bp(MESH:"Growth and Development") regulates bp(HBP:Proteostasis) + bp(GO:"signal transduction") association p(HGNC:HSP90AB1) - - - + + + pubmed:21214928 + + bp(GO:"protein transport") association p(HGNC:APP) + - pmid:25784053 + pubmed:31413141 - complex(p(FPLX:HSPA), p(HGNC:DNAJB1), p(HGNC:HSPH1)) decreases path(MESH:"Protein Aggregation, Pathological") + bp(GO:"protein transport") association p(HGNC:MS4A4A, loc(GO:"plasma membrane")) - pmid:25784053 + pubmed:31413141 - p(HGNC:DNAJB1) negativeCorrelation path(MESH:"Protein Aggregation, Pathological") + bp(GO:"protein transport") association p(HGNC:MS4A4A, loc(GO:cytoplasm)) - pmid:25036637 + pubmed:30740335 - p(HGNC:DNAJB1) increases complex(p(HGNC:DNAJB1), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) + bp(GO:"protein transport") increases p(HGNC:ATF6) - pmid:25784053 + pubmed:27299292 - a(MESH:"Cellular Structures") association p(FPLX:"CCT_complex") + bp(GO:"protein transport") negativeCorrelation p(HGNC:GBA, var("p.Leu444Pro")) - pmid:25784053 + pubmed:27299292 - bp(GO:"intracellular transport") association p(FPLX:"CCT_complex") + bp(GO:"protein transport") positiveCorrelation p(HGNC:TFEB) - pmid:25784053 + pubmed:23746257 - bp(GO:"response to misfolded protein") increases act(p(HGNC:HSF1)) + bp(GO:"protein transport") association p(FPLX:HSP90) - pmid:25784053 + pubmed:22122372 - bp(GO:"response to misfolded protein") increases act(p(HGNC:ERN1), ma(kin)) + complex(a(CHEBI:amyloid-beta), p(HGNC:APP)) regulates bp(CONSO:CONSO00073) - pmid:25784053 + pubmed:22122372 - p(HGNC:HSF1, pmod(Ac)) decreases act(p(HGNC:HSF1)) + complex(p(HGNC:APP), p(HGNC:SPON1)) regulates bp(CONSO:CONSO00073) - - - pmid:25784053 + pubmed:22122372 - complex(a(MESH:"Molecular Chaperones"), p(HGNC:HSF1)) decreases act(p(HGNC:HSF1)) + complex(p(HGNC:APP), p(HGNC:NTN1)) regulates bp(CONSO:CONSO00073) + + - pmid:25784053 + pubmed:27068745 - p(HGNC:PRSS1) decreases p(HGNC:ATF6) + p(HGNC:NTN1) decreases bp(GO:"neuron apoptotic process") - pmid:25784053 + pubmed:21214928 - p(HGNC:PRSS1) increases p(HBP:"N-terminal fragment of ATF6") + bp(GO:"anterograde axonal protein transport") association p(HGNC:APP) - pmid:25784053 + pubmed:21214928 - p(HGNC:PRSS2) decreases p(HGNC:ATF6) + complex(p(HGNC:APP), p(HGNC:KIF5B)) regulates act(p(HGNC:BACE1)) - pmid:25784053 + pubmed:21214928 - p(HGNC:PRSS2) increases p(HBP:"N-terminal fragment of ATF6") + complex(p(HGNC:APP), p(HGNC:KIF5B)) regulates act(p(HGNC:PSEN1)) + + - pmid:25784053 + pubmed:19491104 - tloc(p(HBP:"N-terminal fragment of ATF6"), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) increases act(p(HBP:"N-terminal fragment of ATF6"), ma(tscript)) + p(HGNC:KIF5B) isA complex(GO:"kinesin complex") + + - pmid:25784053 + pubmed:19491104 - act(p(HBP:"N-terminal fragment of ATF6"), ma(tscript)) increases bp(GO:"response to misfolded protein") + p(HGNC:KIF5B) increases complex(a(MESH:Microtubules), p(HGNC:KIF5B)) - pmid:25784053 + pubmed:26813123 - act(p(HGNC:EIF2AK3), ma(kin)) increases p(HGNC:EIF2S1, pmod(Ph)) + complex(p(HGNC:APP), p(HGNC:SLC5A7)) increases tloc(p(HGNC:APP), fromLoc(GO:"cell surface"), toLoc(GO:intracellular)) + + + + - pmid:25784053 + pubmed:21214928 - p(HGNC:EIF2S1, pmod(Ph)) increases act(p(HGNC:EIF2S1), ma(tscript)) + composite(a(CHEBI:"phorbol ester"), p(HGNC:ADAM9), p(HGNC:APP)) increases p(CONSO:CONSO00067) + + - pmid:23702978 + pubmed:21214928 - p(HGNC:EIF2S1, pmod(Ph)) decreases bp(GO:translation) + a(CHEBI:"phorbol ester") association tloc(p(CONSO:CONSO00067), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - - - pmid:25784053 + pubmed:21214928 - act(p(HGNC:EIF2S1), ma(tscript)) increases p(HGNC:ATF4) + a(CHEBI:"phorbol ester") association a(CHEBI:amyloid-beta) - pmid:25784053 + pubmed:21214928 - p(HGNC:DDIT3) increases bp(GO:"apoptotic process") + a(CHEBI:"phorbol ester") increases act(p(HGNC:PRKCA)) - pmid:23702978 + pubmed:21214928 - p(HGNC:DDIT3) regulates a(CHEBI:"calcium(2+)") + bp(GO:"regulation of neuronal synaptic plasticity") association p(CONSO:CONSO00067) - pmid:23702978 + pubmed:12428809 - p(HGNC:DDIT3) increases act(complex(GO:"NLRP3 inflammasome complex")) + bp(GO:"regulation of neuronal synaptic plasticity") association tloc(p(HGNC:APP), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:25784053 + pubmed:21214928 - p(HGNC:ATXN1, var("?")) causesNoChange p(FPLX:HSPA) + complex(p(HGNC:BACE1), p(HGNC:RTN4)) decreases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:amyloid-beta))) @@ -119671,900 +121058,926 @@

Statements

- pmid:25784053 + pubmed:21214928 - p(MGI:Atg5) decreases bp(HP:Neurodegeneration) + complex(p(HGNC:BACE1), p(HGNC:GGA1)) decreases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:amyloid-beta))) + + - pmid:25784053 + pubmed:19126755 - p(MGI:Atg7) decreases bp(HP:Neurodegeneration) + bp(GO:"synaptic transmission, cholinergic") increases bp(GO:cognition) - pmid:24027553 + pubmed:24511233 - p(MGI:Atg7) decreases path(HBP:Neurodegeneration) + bp(GO:"synaptic transmission, cholinergic") association bp(GO:cognition) - pmid:24027553 + pubmed:26813123 - p(MGI:Atg7) decreases p(MGI:Mapt, pmod(Ph)) + bp(GO:"synaptic transmission, cholinergic") association bp(GO:cognition) - pmid:24027553 + pubmed:21482353 - p(MGI:Atg7) decreases p(MGI:Mapt, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212)) + bp(GO:"synaptic transmission, cholinergic") association bp(GO:cognition) - pmid:24027553 + pubmed:19126755 - p(MGI:Atg7) decreases p(MGI:Mapt, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) + bp(GO:"synaptic transmission, cholinergic") negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:24027553 + pubmed:26813123 - p(MGI:Atg7) decreases p(MGI:Mapt, pmod(Ph, Thr, 231)) + bp(GO:"synaptic transmission, cholinergic") association path(MESH:"Alzheimer Disease") - pmid:25784053 + pubmed:19293145 - p(HGNC:RAB1A) increases bp(GO:"autophagosome assembly") + bp(GO:"synaptic transmission, cholinergic") association a(CHEBI:amyloid-beta) - pmid:29238289 + pubmed:19293145 - p(HGNC:RAB1A) association sec(p(HGNC:MAPT)) + bp(GO:"synaptic transmission, cholinergic") association a(CHEBI:amyloid-beta) - pmid:27181519 + pubmed:24511233 - p(HGNC:RAB1A) increases deg(p(HGNC:TARDBP, pmod(HBP:"protein aggregation"))) + bp(GO:"synaptic transmission, cholinergic") association bp(GO:behavior) - pmid:27181519 + pubmed:24511233 - p(HGNC:RAB1A) increases bp(GO:autophagy) + bp(GO:"synaptic transmission, cholinergic") association path(MESH:Schizophrenia) - pmid:27181519 + pubmed:27190210 - p(HGNC:RAB1A) association g(HGNC:C9orf72) + bp(GO:"synaptic transmission, cholinergic") regulates p(HGNC:CHRNA7) - pmid:25784053 + pubmed:27190210 - p(HGNC:SOD1, var("p.Gly576Arg")) decreases a(CHEBI:"N-retinylidene-N-retinylethanolamine") + bp(GO:"synaptic transmission, cholinergic") association bp(MESH:Neuroprotection) - pmid:25784053 + pubmed:27190210 - p(HGNC:SOD1, var("p.Gly576Arg")) decreases p(HGNC:MAP1LC3A) + bp(GO:"synaptic transmission, cholinergic") association path(DOID:"Parkinson's disease") - pmid:25784053 + pubmed:27190210 - p(HGNC:SOD1, var("p.Gly576Arg")) decreases p(HGNC:SQSTM1) + bp(GO:"synaptic transmission, cholinergic") association bp(GO:"oxygen homeostasis") - pmid:25784053 + pubmed:27190210 - p(HGNC:SOD1, var("p.Gly576Arg")) increases bp(GO:autophagy) + bp(GO:"synaptic transmission, cholinergic") association bp(GO:"glucose homeostasis") - pmid:25784053 + pubmed:27190210 - a(CHEBI:chloroquine) decreases bp(GO:autophagy) + bp(GO:"synaptic transmission, cholinergic") association path(DOID:ischemia) - pmid:25784053 + pubmed:17009926 - a(CHEBI:chloroquine) increases a(CHEBI:"N-retinylidene-N-retinylethanolamine") + bp(GO:"synaptic transmission, cholinergic") increases act(a(CHEBI:acetylcholine)) - pmid:25784053 + pubmed:26813123 - a(CHEBI:chloroquine) increases p(HGNC:MAP1LC3A) + bp(GO:"synaptic transmission, cholinergic") regulates act(a(MESH:Neurons)) - pmid:25784053 + pubmed:26813123 - a(CHEBI:chloroquine) increases p(HGNC:SQSTM1) + bp(GO:"synaptic transmission, cholinergic") association path(MESH:Attention) - pmid:24027553 + pubmed:26813123 - a(CHEBI:chloroquine) increases p(HGNC:MAPT) + bp(GO:"synaptic transmission, cholinergic") increases path(MESH:Attention) - pmid:24027553 + pubmed:26813123 - a(CHEBI:chloroquine) decreases deg(p(HGNC:MAPT)) + bp(GO:"synaptic transmission, cholinergic") increases path(MESH:Attention) - pmid:25784053 + pubmed:26813123 - a(CHEBI:radicicol) decreases act(p(FPLX:HSP90)) + bp(GO:"synaptic transmission, cholinergic") association bp(GO:learning) - pmid:21882945 + pubmed:26813123 - a(CHEBI:radicicol) directlyDecreases act(p(FPLX:HSP90)) + bp(GO:"synaptic transmission, cholinergic") positiveCorrelation bp(GO:learning) - pmid:21882945 + pubmed:21482353 - a(CHEBI:radicicol) directlyIncreases complex(a(CHEBI:radicicol), p(INTERPRO:"Heat shock protein Hsp90, N-terminal")) + bp(GO:"synaptic transmission, cholinergic") association bp(GO:learning) - pmid:25784053 + pubmed:26813123 - a(CHEBI:tanespimycin) decreases act(p(FPLX:HSP90)) + bp(GO:"synaptic transmission, cholinergic") association bp(GO:memory) - pmid:30116051 + pubmed:21482353 - a(CHEBI:tanespimycin) decreases act(p(FPLX:HSP90)) + bp(GO:"synaptic transmission, cholinergic") association bp(GO:memory) - pmid:21882945 + pubmed:22040696 - a(CHEBI:tanespimycin) directlyDecreases act(p(FPLX:HSP90)) + bp(GO:"synaptic transmission, cholinergic") increases bp(GO:memory) - pmid:21882945 + pubmed:26813123 - a(CHEBI:tanespimycin) decreases act(p(FPLX:HSP90)) + bp(GO:"synaptic transmission, cholinergic") association bp(GO:"response to stress") - pmid:29311797 + pubmed:26813123 - a(CHEBI:tanespimycin) decreases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) + bp(GO:"synaptic transmission, cholinergic") association bp(GO:"regulation of circadian sleep/wake cycle, wakefulness") - pmid:21367866 + pubmed:26813123 - a(CHEBI:tanespimycin) decreases act(p(FPLX:HSP90)) + bp(GO:"synaptic transmission, cholinergic") association bp(GO:"regulation of circadian sleep/wake cycle, sleep") - pmid:30116051 + pubmed:26813123 - a(CHEBI:tanespimycin) decreases a(CHEBI:"amyloid-beta") + bp(GO:"synaptic transmission, cholinergic") association bp(GO:"sensory processing") - pmid:30116051 + pubmed:21482353 - a(CHEBI:tanespimycin) increases bp(GO:memory) + bp(GO:"synaptic transmission, cholinergic") association bp(GO:"sensory processing") - pmid:30116051 + pubmed:26813123 - a(CHEBI:tanespimycin) decreases p(HGNC:MAPT) + bp(GO:"synaptic transmission, cholinergic") regulates bp(GO:"circadian sleep/wake cycle") - pmid:30116051 + pubmed:26813123 - a(CHEBI:tanespimycin) decreases a(HBP:"alpha-synuclein oligomers") + bp(GO:"synaptic transmission, cholinergic") association path(CONSO:Neurodegeneration) - pmid:21882945 + pubmed:26813123 - a(CHEBI:tanespimycin) directlyIncreases complex(a(CHEBI:tanespimycin), p(INTERPRO:"Heat shock protein Hsp90, N-terminal")) + bp(GO:"synaptic transmission, cholinergic") association path(MESH:Dementia) - pmid:21882945 + pubmed:24590577 - a(CHEBI:tanespimycin) decreases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) + bp(GO:"synaptic transmission, cholinergic") association path(MESH:"Plaque, Amyloid") - pmid:21882945 + pubmed:24590577 - a(CHEBI:tanespimycin) decreases p(HGNC:MAPT, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) + bp(GO:"synaptic transmission, cholinergic") association path(MESH:"Neurofibrillary Tangles") - pmid:29311797 + pubmed:21482353 - a(CHEBI:tanespimycin) decreases p(HGNC:MAPT, pmod(Ph)) + bp(GO:"synaptic transmission, cholinergic") association path(MESH:Anxiety) - pmid:25784053 + pubmed:21482353 - a(PUBCHEM:377503130) increases act(p(HGNC:HSF1)) + bp(GO:"synaptic transmission, cholinergic") association path(MESH:Depression) - pmid:25784053 + pubmed:21482353 - a(PUBCHEM:377503130) decreases act(p(FPLX:"CCT_complex")) + bp(GO:"synaptic transmission, cholinergic") association p(HGNC:LYNX1) - pmid:30116051 + pubmed:11230871 - p(FPLX:mTORC1) increases bp(GO:macroautophagy) + bp(GO:"synaptic transmission, cholinergic") association a(PUBCHEM:5662) - pmid:30116051 + pubmed:21214928 - p(FPLX:mTORC1) decreases bp(GO:macroautophagy) + p(HGNC:APP, frag("672_713")) increases a(CONSO:CONSO00038) - pmid:30116051 + pubmed:21214928 - p(FPLX:mTORC1) decreases bp(GO:macroautophagy) + p(HGNC:APP, frag("672_713")) increases a(CONSO:CONSO00038) - pmid:30116051 + pubmed:22122372 - p(FPLX:mTORC1) increases bp(GO:macroautophagy) + p(HGNC:APP, frag("672_713")) increases a(CONSO:CONSO00038) - pmid:30116051 + pubmed:21214928 - p(FPLX:mTORC1) decreases bp(GO:mitophagy) + p(HGNC:APP, frag("672_713")) increases path(MESH:"Alzheimer Disease") - - - pmid:30116051 + pubmed:21214928 - p(FPLX:mTORC1) increases p(HGNC:ULK1, pmod(Ph, Ser, 757)) + p(HGNC:APP, frag("672_713")) increases a(CONSO:CONSO00022) - pmid:30116051 + pubmed:22122372 - p(FPLX:mTORC1) decreases tloc(p(HGNC:TFEB), fromLoc(MESH:Cytoplasm), toLoc(MESH:"Cell Nucleus")) + p(HGNC:APP, frag("672_713")) increases a(CONSO:CONSO00022) - pmid:30116051 + pubmed:21214928 - act(p(FPLX:mTORC1)) increases act(p(HGNC:TFEB)) + p(HGNC:APP, frag("672_713")) increases path(MESH:"Plaque, Amyloid") - pmid:30116051 + pubmed:22122372 - act(p(FPLX:mTORC1)) increases act(p(HGNC:NFE2L2)) + p(HGNC:APP, frag("672_713")) increases path(MESH:"Plaque, Amyloid") - pmid:30116051 + pubmed:22122372 - p(FPLX:mTORC1) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + p(HGNC:APP, frag("672_713")) increases path(MESH:"Plaque, Amyloid") - pmid:30116051 + url:"https://www.ncbi.nlm.nih.gov/clinvar/RCV000019448/" - p(FPLX:mTORC1) decreases bp(GO:"proteasome assembly") + p(HGNC:APP, frag("672_713")) isA a(CHEBI:amyloid-beta) - pmid:23528736 + pubmed:25468261 - p(FPLX:mTORC1) decreases bp(GO:autophagy) + p(HGNC:APP, frag("672_713")) positiveCorrelation a(CONSO:"CDR - Sum of Boxes") - pmid:23528736 + pubmed:19926167 - act(p(FPLX:mTORC1), ma(kin)) increases p(HGNC:ULK1, pmod(Ph)) + p(HGNC:APP, frag("672_713")) association p(HGNC:CTSD) - pmid:23528736 + pubmed:23022416 - act(p(FPLX:mTORC1)) increases p(HGNC:MAPT) + p(HGNC:APP, frag("672_713")) negativeCorrelation g(DBSNP:rs3818361) + + - pmid:30108137 + pubmed:22107728 - act(p(FPLX:mTORC1)) increases p(MGI:Tfeb, pmod(Ph)) + p(HGNC:APP, frag("672_713")) positiveCorrelation g(DBSNP:rs4646953) - pmid:25784053 + pubmed:21673407 - a(PUBCHEM:10521421) decreases act(p(FPLX:AKT)) + p(HGNC:APP, frag("672_713")) positiveCorrelation complex(a(NIFT:"Pittsburgh Compound B"), p(HGNC:HTR4)) - pmid:25784053 + pubmed:22550605 - a(PUBCHEM:10521421) increases bp(GO:autophagy) + p(HGNC:APP, frag("672_713")) increases a(CHEBI:"reactive oxygen species") - pmid:25784053 + pubmed:21543606 - a(CHEBI:fluphenazine) increases bp(GO:autophagy) + p(HGNC:APP, frag("672_713")) association p(HGNC:CLU) - pmid:25784053 + pubmed:21543606 - a(CHEBI:fluphenazine) decreases p(HGNC:TARDBP) + p(HGNC:APP, frag("672_713")) decreases a(MESH:Oligodendroglia) - pmid:25784053 + pubmed:14970312 - a(CHEBI:methotrimeprazine) increases bp(GO:autophagy) + p(HGNC:APP, frag("672_713")) increases bp(MESH:"Oxidative Stress") - pmid:25784053 + pubmed:14970312 - a(CHEBI:methotrimeprazine) decreases p(HGNC:TARDBP) + p(HGNC:APP, frag("672_713")) increases bp(MESH:"Oxidative Stress") - pmid:25784053 + pubmed:14970312 - a(PUBCHEM:799645) increases bp(GO:autophagy) + p(HGNC:APP, frag("672_713")) increases a(CHEBI:ceramide) - pmid:25784053 + pubmed:14970312 - a(PUBCHEM:799645) decreases p(HGNC:SNCA, var("p.Ala53Thr")) + p(HGNC:APP, frag("672_713")) increases a(CHEBI:cholesterol) - pmid:25784053 + pubmed:14970312 - a(PUBCHEM:799645) decreases a(HBP:"huntingtin aggregates") + p(HGNC:APP, frag("672_713")) association bp(GO:"regulation of lipid metabolic process") - pmid:25784053 + pubmed:21722302 - a(PUBCHEM:877863) increases bp(GO:autophagy) + p(HGNC:APP, frag("672_713")) isA a(MESH:"Amyloidogenic Proteins") - pmid:25784053 + pubmed:21722302 - a(PUBCHEM:877863) decreases p(HGNC:SNCA, var("p.Ala53Thr")) + p(HGNC:APP, frag("672_713")) increases path(HP:"Senile plaques") - pmid:25784053 + pubmed:27094130 - a(PUBCHEM:877863) decreases a(HBP:"huntingtin aggregates") + tloc(p(HGNC:APP, frag("672_713")), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) positiveCorrelation act(p(HGNC:DAPK1), ma(go:0016301 ! "kinase activity")) - pmid:25784053 + pubmed:29540553 - a(PUBCHEM:1560402) increases bp(GO:autophagy) + p(HGNC:APP, frag("672_713")) decreases p(MGI:Sirt3) - pmid:25784053 + pubmed:29559585 - a(PUBCHEM:1560402) decreases p(HGNC:SNCA, var("p.Ala53Thr")) + p(HGNC:APP, frag("672_713")) increases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 280)) - pmid:25784053 + pubmed:29559585 - a(PUBCHEM:1560402) decreases a(HBP:"huntingtin aggregates") + p(HGNC:APP, frag("672_713")) increases a(CHEBI:"nitric oxide") - - - - - pmid:25784053 + pubmed:22122372 - composite(a(CHEBI:sirolimus), a(PUBCHEM:799645)) decreases p(HGNC:SNCA, var("p.Ala53Thr")) + p(HGNC:APP, frag("672_711")) decreases path(CONSO:CONSO00061) - - - - - pmid:25784053 + url:"https://www.ncbi.nlm.nih.gov/clinvar/RCV000019448/" - composite(a(CHEBI:sirolimus), a(PUBCHEM:877863)) decreases p(HGNC:SNCA, var("p.Ala53Thr")) + p(HGNC:APP, frag("672_711")) isA a(CHEBI:amyloid-beta) - + + + pubmed:24401760 + + p(HGNC:APP, frag("672_711")) positiveCorrelation path(MESH:"Alzheimer Disease") + - pmid:25784053 + pubmed:21214928 - composite(a(CHEBI:sirolimus), a(PUBCHEM:1560402)) decreases p(HGNC:SNCA, var("p.Ala53Thr")) + path(MESH:"Down Syndrome") increases a(CONSO:CONSO00018) - pmid:25784053 + pubmed:17009926 - a(PUBCHEM:675434) decreases p(HGNC:MAPT) + path(MESH:"Down Syndrome") negativeCorrelation act(p(FPLX:CHRN)) - pmid:23528736 + pubmed:17009926 - a(PUBCHEM:675434) increases deg(p(HGNC:MAPT)) + path(MESH:"Down Syndrome") negativeCorrelation p(FPLX:CHRN) - pmid:25784053 + pubmed:26813123 - a(PUBCHEM:675434) decreases p(HGNC:TARDBP) + path(MESH:"Down Syndrome") negativeCorrelation a(MESH:"Cholinergic Neurons") - pmid:25784053 + pubmed:22299660 - a(PUBCHEM:675434) decreases p(HGNC:ATXN3) + path(MESH:"Down Syndrome") negativeCorrelation p(FPLX:PPP2) - pmid:25784053 + pubmed:22908190 - a(PUBCHEM:675434) decreases act(p(HGNC:USP14)) + path(MESH:"Down Syndrome") negativeCorrelation bp(GO:"regulation of endosome size") - pmid:23528736 + pubmed:28137862 - a(PUBCHEM:675434) decreases act(p(HGNC:USP14)) + path(MESH:"Down Syndrome") association p(HGNC:DYRK1A) - pmid:25784053 + pubmed:28250274 - a(PUBCHEM:675434) causesNoChange p(FPLX:Proteasome) + path(MESH:"Down Syndrome") negativeCorrelation p(HGNC:MME) - pmid:23528736 + pubmed:21214928 - a(PUBCHEM:675434) increases act(p(FPLX:Proteasome)) + p(HGNC:CTSB) increases a(CHEBI:amyloid-beta) - + + + pubmed:22122372 + + p(HGNC:CTSB) increases deg(a(CHEBI:amyloid-beta)) + - pmid:18930136 + pubmed:23516100 - deg(a(CHEBI:oligopeptide)) increases a(CHEBI:"amino acid") + p(HGNC:CTSB) increases act(p(HGNC:BACE1)) - pmid:26702100 + pubmed:23516100 - a(CHEBI:"amino acid") regulates act(p(HGNCGENEFAMILY:"MTOR complex 1")) + act(p(HGNC:CTSB)) increases a(CHEBI:"amyloid-beta polypeptide 40", loc(GO:"secretory vesicle")) - pmid:26702100 + pubmed:23516100 - a(CHEBI:"amino acid") increases p(HGNC:MTOR) + p(HGNC:CTSB) increases p(CONSO:"amyloid-beta aggregates") - pmid:26702100 + pubmed:23516100 - a(CHEBI:"amino acid") increases p(HGNC:MTOR) + p(HGNC:CTSB) negativeCorrelation bp(GO:memory) - pmid:26702100 + pubmed:22908190 - a(CHEBI:"amino acid") increases p(HGNC:RPS6KB1, pmod(Ph, Thr, 389)) + p(HGNC:CTSB) positiveCorrelation act(a(GO:synapse)) + + - pmid:18930136 + pubmed:21214928 - bp(GO:"antigen processing and presentation") association bp(GO:autophagy) + complex(p(CONSO:CONSO00042), p(HGNC:TNFRSF21)) association bp(GO:"synapse pruning") - pmid:18930136 + pubmed:21214928 - bp(GO:"autophagosome-lysosome fusion") increases bp(GO:"protein catabolic process") + complex(p(CONSO:CONSO00042), p(HGNC:TNFRSF21)) association bp(GO:"neuron death") + + - pmid:18930136 + pubmed:21214928 - bp(GO:"autophagosome-lysosome fusion") increases bp(GO:autophagy) + p(CONSO:CONSO00042) increases p(HGNC:TTR) - pmid:27181519 + pubmed:21214928 - bp(GO:"autophagosome-lysosome fusion") increases a(GO:autolysosome) + p(CONSO:CONSO00042) increases p(HGNC:KL) - pmid:27181519 + pubmed:22122372 - bp(GO:"autophagosome-lysosome fusion") increases a(GO:autolysosome) + p(CONSO:CONSO00042) increases path(CONSO:CONSO00061) + + + + + + - pmid:18930136 + pubmed:21214928 - bp(GO:"autophagy of nucleus") isA bp(GO:macroautophagy) + bp(GO:"synapse pruning") association complex(p(CONSO:CONSO00042), p(HGNC:TNFRSF21)) - pmid:18930136 + pubmed:21214928 - bp(GO:pexophagy) isA bp(GO:macroautophagy) + p(CONSO:CONSO00024) increases path(CONSO:CONSO00027) + + + + + + + + + + + + - pmid:18930136 + pubmed:22122372 - bp(GO:reticulophagy) isA bp(GO:macroautophagy) + p(CONSO:CONSO00069) increases path(CONSO:CONSO00061) - pmid:18930136 + pubmed:22122372 - bp(GO:xenophagy) isA bp(GO:macroautophagy) + p(CONSO:CONSO00069) increases act(p(HGNC:CASP3)) - pmid:18930136 + pubmed:22122372 - bp(GO:ribophagy) isA bp(GO:macroautophagy) + p(CONSO:CONSO00069) increases p(HGNC:APP, frag("672_713")) - pmid:18930136 + pubmed:22122372 - bp(GO:aggrephagy) isA bp(GO:macroautophagy) + p(CONSO:CONSO00070) increases path(CONSO:CONSO00061) @@ -120573,48 +121986,49 @@

Statements

+ + - pmid:18930136 + pubmed:21214928 - complex(a(MESH:Proteins), p(HGNC:HSPA8)) increases bp(GO:"chaperone-mediated autophagy") + complex(p(HGNC:APP), p(HGNC:NCSTN), p(HGNC:NOTCH1)) increases complex(complex(FPLX:"Gamma_secretase"), p(HGNC:APP)) - pmid:18930136 + pubmed:21214928 - complex(a(MESH:Proteins), p(HGNC:HSPA8)) increases complex(a(MESH:Proteins), p(HGNC:HSPA8), p(HGNC:LAMP2)) + p(HGNC:BSG) decreases a(CHEBI:amyloid-beta) - - - - - - - + + + pubmed:21214928 + + p(HGNC:BSG) causesNoChange a(CHEBI:amyloid-beta) + - pmid:18930136 + pubmed:21214928 - composite(p(HGNC:ATG10), p(HGNC:ATG7)) increases complex(p(HGNC:ATG12), p(HGNC:ATG5)) + p(HGNC:TMED10) regulates a(CHEBI:amyloid-beta) - pmid:18930136 + pubmed:21214928 - composite(p(HGNC:ATG10), p(HGNC:ATG7)) increases a(GO:phagophore) + complex(complex(FPLX:"Gamma_secretase"), p(CONSO:CONSO00024), p(HGNC:GSAP)) increases a(CHEBI:amyloid-beta) @@ -120623,20 +122037,15 @@

Statements

- - - pmid:18930136 - - complex(p(HGNC:ATG12), p(HGNC:ATG5)) increases complex(p(HGNC:ATG12), p(HGNC:ATG16L1), p(HGNC:ATG5)) - + - pmid:18930136 + pubmed:30061532 - complex(p(HGNC:ATG12), p(HGNC:ATG5)) increases p(HGNC:GABARAPL2, pmod(GO:"protein lipidation")) + p(HGNC:ERBB4) association path(MESH:Schizophrenia) @@ -120649,109 +122058,163 @@

Statements

- pmid:18930136 + pubmed:21718217 - complex(p(HGNC:ATG12), p(HGNC:ATG16L1), p(HGNC:ATG5)) increases a(GO:phagophore) + p(HGNC:MME) increases deg(a(CHEBI:amyloid-beta)) - + + + pubmed:26195256 + + p(HGNC:MME) increases deg(a(CHEBI:amyloid-beta, loc(GO:"extracellular region"))) + - pmid:18930136 + pubmed:29626319 - p(HGNC:GABARAPL2) increases complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:GABARAPL2)) + p(HGNC:MME) increases deg(a(CHEBI:amyloid-beta)) - pmid:18930136 + pubmed:29626319 - p(HGNC:ATG4A) increases p(HGNC:GABARAPL2, frag("?")) + p(HGNC:MME) increases deg(a(CHEBI:amyloid-beta)) - pmid:18930136 + pubmed:29626319 - p(HGNC:ATG4A) increases complex(p(HGNC:ATG4A), p(HGNC:ATG7)) + p(HGNC:MME) increases deg(a(CHEBI:amyloid-beta)) - + + + pubmed:29626319 + + p(HGNC:MME) increases deg(a(CHEBI:amyloid-beta)) + - + + + pubmed:29626319 + + act(p(HGNC:MME)) increases deg(a(CHEBI:amyloid-beta)) + + + + pubmed:28250274 + + p(HGNC:MME) increases deg(a(CHEBI:amyloid-beta)) + + - pmid:18930136 + pubmed:27209302 - composite(p(HGNC:ATG12), p(HGNC:ATG3), p(HGNC:ATG5)) increases complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:GABARAPL2, frag("?"))) + p(HGNC:MME) increases deg(p(CONSO:sAPP-beta)) - + + + pubmed:30116051 + + p(HGNC:MME) increases deg(a(CHEBI:"amyloid-beta polypeptide 42")) + - + + + pubmed:30116051 + + act(p(HGNC:MME)) decreases path(MESH:"Plaque, Amyloid") + + + + pubmed:29626319 + + p(HGNC:MME) increases bp(GO:behavior) + + - pmid:18930136 + pubmed:28250274 - complex(a(GO:"multivesicular body"), a(GO:autophagosome), a(GO:endosome)) increases a(GO:amphisome) + p(HGNC:MME) negativeCorrelation path(MESH:"Down Syndrome") - + + + pubmed:28250274 + + p(HGNC:MME) negativeCorrelation p(HGNC:DYRK1A) + - pmid:18930136 + pubmed:24653673 - complex(a(GO:amphisome), a(GO:lysosome)) increases a(GO:autolysosome) + p(HGNC:EGFR) increases p(HGNC:PPP2CA, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) - + + + pubmed:24653673 + + p(HGNC:EGFR) increases p(HGNC:PPP2CB, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) + - pmid:18930136 + pubmed:23393546 - p(HGNC:GABARAP) increases complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:GABARAP)) + p(HGNC:EGFR) increases bp(GO:"MAPK cascade") - + + + pubmed:30640040 + + p(HGNC:EGFR) association a(PUBCHEM:24756910) + @@ -120765,174 +122228,173 @@

Statements

- pmid:18930136 + pubmed:21214928 - complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:MAP1LC3B)) increases complex(a(CHEBI:phosphatidylethanolamine), a(GO:phagophore), p(HGNC:MAP1LC3B)) + complex(p(CONSO:CONSO00069), p(HGNC:APP)) increases p(CONSO:CONSO00069) - pmid:18930136 + pubmed:22122372 - complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:MAP1LC3B)) association a(GO:autophagosome) + bp(GO:"neurofibrillary tangle assembly") association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - - - + + + pubmed:22122372 + + bp(GO:"neurofibrillary tangle assembly") association path(MESH:"Alzheimer Disease") + - pmid:18930136 + pubmed:25687773 - path(MESH:"Creutzfeldt-Jakob Syndrome") positiveCorrelation a(GO:autophagosome) + bp(GO:"neurofibrillary tangle assembly") association g(DBSNP:rs393152) - pmid:18930136 + pubmed:30108137 - path(MESH:"Neuronal Ceroid-Lipofuscinoses") negativeCorrelation act(a(GO:lysosome)) + bp(GO:"neurofibrillary tangle assembly") increases g(HGNC:TFEB) - pmid:18930136 + pubmed:28420982 - p(HGNC:CLN3, var("?")) increases path(MESH:"Neuronal Ceroid-Lipofuscinoses") + bp(GO:"neurofibrillary tangle assembly") association a(MESH:"Heparan Sulfate Proteoglycans") - - - pmid:18930136 + pubmed:19363271 - p(HGNC:ATP13A2, var("?")) increases bp(GO:"proteasomal protein catabolic process") + bp(GO:"neurofibrillary tangle assembly") positiveCorrelation p(FPLX:HSP90) - pmid:18930136 + pubmed:17050703 - p(HGNC:ATP13A2, var("?")) increases path(HBP:Neurodegeneration) + bp(GO:"neurofibrillary tangle assembly") positiveCorrelation p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) - - - pmid:18930136 + pubmed:22122372 - p(HGNC:RAB7A, var("?")) decreases bp(GO:"autophagosome-lysosome fusion") + a(CONSO:CONSO00038) increases path(MESH:"Plaque, Amyloid") - pmid:18930136 + pubmed:21718217 - a(MESH:Dyneins) increases bp(GO:"autophagosome-lysosome fusion") + a(CONSO:CONSO00038) increases p(HGNC:CCL2) - pmid:26631930 + pubmed:21718217 - act(a(MESH:Dyneins)) association p(HGNC:MAPT) + a(CONSO:CONSO00038) increases bp(GO:"microglial cell activation") - pmid:18930136 + pubmed:21718217 - p(HGNC:DCTN1, var("?")) positiveCorrelation a(GO:autophagosome) + act(a(CONSO:CONSO00038)) increases bp(GO:phagocytosis) - - - pmid:8391280 + pubmed:28019679 - p(HGNC:DCTN1) association p(INTERPRO:"MAP2/Tau projection") + a(CONSO:CONSO00038) increases act(complex(GO:"NLRP3 inflammasome complex")) - pmid:8391280 + pubmed:24561250 - p(HGNC:DCTN1) isA complex(p(HGNC:DCTN1), p(HGNC:MAPT)) + a(CONSO:CONSO00038) increases act(complex(GO:"NLRP3 inflammasome complex")) - pmid:8391280 + pubmed:21718217 - p(HGNC:DCTN1) isA p(INTERPRO:"Dynein associated protein") + a(CONSO:CONSO00022) decreases bp(GO:"synaptic signaling") - pmid:26702100 + pubmed:21718217 - p(HGNC:DCTN1) increases bp(GO:"autophagosome-lysosome fusion") + a(CONSO:CONSO00022) increases bp(GO:"neuron death") - pmid:26702100 + pubmed:21214928 - p(HGNC:DCTN1) increases bp(GO:"autophagosome-lysosome fusion") + complex(a(CHEBI:amyloid-beta), p(HGNC:DNM1)) decreases p(CONSO:CONSO00069) + + - pmid:18930136 + pubmed:22110360 - bp(GO:"protein monoubiquitination") increases bp(GO:endocytosis) + act(p(HGNC:DNM1)) increases bp(GO:endocytosis) - pmid:18930136 + pubmed:22110360 - a(GO:aggresome) negativeCorrelation bp(GO:"cell death") + act(p(HGNC:DNM1)) increases bp(GO:"synaptic vesicle budding from endosome") @@ -120941,906 +122403,1073 @@

Statements

+ + - pmid:18930136 + pubmed:30515821 - composite(a(CHEBI:lactacystin), a(CHEBI:sirolimus)) decreases bp(GO:"apoptotic process") + act(p(HGNC:DNM1)) increases path(DOID:"Parkinson's disease") - pmid:18930136 + pubmed:30515821 - composite(a(CHEBI:lactacystin), a(CHEBI:sirolimus)) decreases p(MESH:Proteins, pmod(Ub)) + p(HGNC:DNM1) increases path(DOID:"Parkinson's disease") - pmid:18930136 + pubmed:30515821 - p(HGNC:HDAC6) regulates bp(GO:autophagy) + p(HGNC:DNM1) decreases path(MESH:Neuroprotection) - pmid:18930136 + pubmed:30515821 - p(HGNC:HDAC6) increases bp(GO:autophagy) + p(HGNC:DNM1) increases bp(GO:"programmed cell death") - pmid:18930136 + pubmed:30515821 - p(HGNC:HDAC6) regulates bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + p(HGNC:DNM1) negativeCorrelation path(MESH:"Mitochondrial Dynamics") - pmid:18930136 + pubmed:30515821 - p(HGNC:HDAC6) regulates a(GO:aggresome) + p(HGNC:DNM1) negativeCorrelation path(MESH:"Mitochondrial Dynamics") + + + + - pmid:18930136 + pubmed:30515821 - p(HGNC:HDAC6) increases tloc(p(MESH:Proteins, pmod(Ub)), fromLoc(GO:cytoplasm), toLoc(GO:lysosome)) + act(p(HGNC:DNM1), ma(GO:"GTPase activity")) increases a(MESH:Mitochondria) - pmid:18930136 + pubmed:30515821 - p(HGNC:HDAC6) increases bp(GO:"Hsp90 deacetylation") + p(HGNC:DNM1) causesNoChange a(MESH:Mitochondria, loc(GO:"synaptic vesicle")) + + - pmid:18930136 + pubmed:30515821 - p(HGNC:HDAC6) regulates complex(GO:"chaperone complex") + p(HGNC:DNM1) positiveCorrelation path(OMIT:0010462) - pmid:18930136 + pubmed:30515821 - p(HGNC:HDAC6) increases bp(GO:"ubiquitin-dependent protein catabolic process") + p(HGNC:DNM1) positiveCorrelation bp(GO:memory) - pmid:28803412 + pubmed:30515821 - p(HGNC:HDAC6) decreases a(HBP:HBP00093) + p(HGNC:DNM1) decreases bp(GO:"neuron death") - pmid:30640040 + pubmed:30515821 - p(HGNC:HDAC6) association a(PUBCHEM:53340666) + p(HGNC:DNM1) increases tloc(a(CHEBI:ATP), fromLoc(GO:mitochondrion), toLoc(GO:"axon cytoplasm")) - pmid:29311797 + pubmed:30515821 - p(HGNC:HDAC6) increases act(p(HGNC:AIP)) + p(HGNC:DNM1) positiveCorrelation bp(GO:"synaptic vesicle cycle") - pmid:29311797 + pubmed:30515821 - p(HGNC:HDAC6) association a(HBP:"Tau aggregates") + p(HGNC:DNM1) increases a(OMIT:0012627) + + - pmid:26751493 + pubmed:30515821 - p(HGNC:HDAC6) association p(HBP:"microtubule-binding region") + p(HGNC:DNM1) decreases path(OMIT:0002643) - pmid:26751493 + pubmed:30515821 - p(HGNC:HDAC6) association p(HBP:"microtubule-binding region") + p(HGNC:DNM1) positiveCorrelation bp(GO:"motor behavior") - pmid:26631930 + pubmed:30515821 - p(HGNC:HDAC6) decreases p(HGNC:MAPT, pmod(Ac, Lys)) + p(HGNC:DNM1) decreases bp(GO:"mitochondrial fusion") - pmid:25031639 + pubmed:30515821 - act(p(HGNC:HDAC6)) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + p(HGNC:DNM1) increases bp(GO:mitophagy) - pmid:25031639 + pubmed:30515821 - act(p(HGNC:HDAC6)) increases p(HGNC:MAPT, pmod(Ph, Ser, 356)) + p(HGNC:DNM1) positiveCorrelation bp(GO:"oxidative phosphorylation") - pmid:25546293 + pubmed:30515821 - act(p(HGNC:HDAC6)) decreases p(HGNC:CTNNB1, pmod(Ac, Lys, 49)) + act(p(HGNC:DNM1)) increases path(DOID:"neurodegenerative disease") - pmid:25546293 + pubmed:30515821 - act(p(HGNC:HDAC6)) decreases p(HGNC:CTNNB1, pmod(Ph, Ser, 45)) + p(HGNC:DNM1) decreases a(GO:synapse) - pmid:25546293 + pubmed:30515821 - act(p(HGNC:HDAC6)) causesNoChange p(HGNC:CTNNB1, pmod(Ph, Ser, 33)) + p(HGNC:DNM1) increases bp(GO:"inflammatory response") + + + + - pmid:25546293 + pubmed:30515821 - act(p(HGNC:HDAC6)) causesNoChange p(HGNC:CTNNB1, pmod(Ph, Ser, 37)) + p(HGNC:DNM1) increases a(OMIT:0016987) - pmid:25546293 + pubmed:30515821 - act(p(HGNC:HDAC6)) causesNoChange p(HGNC:CTNNB1, pmod(Ph, Thr, 41)) + p(HGNC:DNM1) positiveCorrelation bp(GO:"immunological synapse formation") - pmid:23487739 + pubmed:30515821 - p(HGNC:HDAC6) decreases a(GO:microtubule) + p(HGNC:DNM1) increases a(CHEBI:"hydrogen peroxide") - pmid:28760828 + pubmed:30515821 - p(HGNC:HDAC6) increases p(HGNC:MAPT, pmod(Ac, Lys, 321)) + p(HGNC:DNM1) increases bp(OMIT:0016017) - pmid:28760828 + pubmed:30515821 - p(HGNC:HDAC6) increases p(HGNC:MAPT) + p(HGNC:DNM1) increases a(CHEBI:amyloid-beta) - pmid:28760828 + pubmed:30515821 - p(HGNC:HDAC6) increases p(HGNC:MAPT, pmod(Ph, Ser, 324)) + p(HGNC:DNM1) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + - pmid:27181519 + pubmed:30515821 - p(HGNC:HDAC6) increases bp(GO:"autophagosome-lysosome fusion") + act(p(HGNC:DNM1)) increases bp(GO:"mitochondrial fission") + + - pmid:27181519 + pubmed:19721446 - p(HGNC:HDAC6) increases bp(GO:"stress granule assembly") + p(HGNC:DNM1) association p(HGNC:CHRNB2) - pmid:27181519 + pubmed:29590627 - act(p(HGNC:HDAC6)) negativeCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") + act(p(HGNC:DNM1)) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) - pmid:18930136 + pubmed:29590627 - p(HGNC:WDFY3) regulates bp(GO:autophagy) + act(p(HGNC:DNM1)) increases tloc(a(CONSO:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) - pmid:18930136 + pubmed:29590627 - p(HGNC:WDFY3) regulates bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + act(p(HGNC:DNM1)) increases tloc(a(CONSO:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) - pmid:18930136 + pubmed:21214928 - p(HGNC:WDFY3) regulates a(GO:aggresome) + a(MESH:"Potassium Channels") association a(CHEBI:amyloid-beta) - pmid:18930136 + pubmed:21214928 - tloc(p(HGNC:WDFY3), fromLoc(GO:nucleus), toLoc(GO:cytoplasm)) increases bp(GO:"protein ubiquitination") + complex(p(HGNC:APBA1), p(HGNC:APP)) regulates bp(GO:"protein transport") - pmid:18930136 + pubmed:21214928 - p(HGNC:WDFY3) increases bp(GO:"ubiquitin-dependent protein catabolic process") + complex(p(HGNC:APBA1), p(HGNC:APP)) association p(CONSO:CONSO00067) - pmid:18930136 + pubmed:21214928 - bp(GO:"Hsp90 deacetylation") increases act(p(HGNC:HSF1)) + complex(p(HGNC:APBA1), p(HGNC:APP)) association tloc(p(CONSO:CONSO00067), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:18930136 + pubmed:21214928 - a(MESH:"Huntingtin Protein") association p(HGNC:SQSTM1) + complex(p(HGNC:APBA1), p(HGNC:APP)) association a(CHEBI:amyloid-beta) - pmid:24563850 + pubmed:21214928 - a(CHEBI:radical) association bp(GO:"detection of redox state") + complex(p(HGNC:APBA1), p(HGNC:APP)) association tloc(a(CHEBI:amyloid-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:24563850 + pubmed:21214928 - a(CHEBI:radical) regulates bp(GO:"intracellular receptor signaling pathway") + complex(p(HGNC:APBA2), p(HGNC:APP)) regulates bp(GO:"protein transport") - pmid:24563850 + pubmed:21214928 - a(CHEBI:radical) regulates bp(MESH:Metabolism) + complex(p(HGNC:APBA2), p(HGNC:APP)) association p(CONSO:CONSO00067) - pmid:24563850 + pubmed:21214928 - a(CHEBI:radical) decreases a(MESH:Antioxidants) + complex(p(HGNC:APBA2), p(HGNC:APP)) association tloc(p(CONSO:CONSO00067), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:24563850 + pubmed:21214928 - a(CHEBI:radical) association bp(MESH:"Host-Pathogen Interactions") + complex(p(HGNC:APBA2), p(HGNC:APP)) association a(CHEBI:amyloid-beta) - pmid:24563850 + pubmed:21214928 - a(CHEBI:radical) increases bp(HBP:"non-enzymatic protein modification") + complex(p(HGNC:APBA2), p(HGNC:APP)) association tloc(a(CHEBI:amyloid-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:24563850 + pubmed:21214928 - a(CHEBI:radical) increases bp(HBP:misfolding) + complex(p(HGNC:APBA3), p(HGNC:APP)) regulates bp(GO:"protein transport") - pmid:24563850 + pubmed:21214928 - a(CHEBI:radical) increases bp(GO:"protein oxidation") + complex(p(HGNC:APBA3), p(HGNC:APP)) association p(CONSO:CONSO00067) - pmid:24563850 + pubmed:21214928 - a(CHEBI:radical) increases bp(MESH:"Protein Carbonylation") + complex(p(HGNC:APBA3), p(HGNC:APP)) association tloc(p(CONSO:CONSO00067), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:24563850 + pubmed:21214928 - act(p(HGNC:XDH)) increases a(CHEBI:radical) + complex(p(HGNC:APBA3), p(HGNC:APP)) association a(CHEBI:amyloid-beta) - pmid:24563850 + pubmed:21214928 - act(p(HGNC:XDH)) increases a(CHEBI:"reactive oxygen species") + complex(p(HGNC:APBA3), p(HGNC:APP)) association tloc(a(CHEBI:amyloid-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + - pmid:24563850 + pubmed:21214928 - act(p(HGNC:XDH)) increases a(CHEBI:"reactive nitrogen species") + p(HGNC:RAB6A) association bp(CONSO:CONSO00073) - pmid:24563850 + pubmed:21214928 - act(p(HGNCGENEFAMILY:"Cytochrome P450 family 1")) increases a(CHEBI:radical) + bp(GO:"clathrin-dependent endocytosis") increases deg(p(HGNC:APP)) - pmid:24563850 + pubmed:30027901 - act(p(HGNCGENEFAMILY:"Cytochrome P450 family 1")) increases a(CHEBI:"reactive oxygen species") + bp(GO:"clathrin-dependent endocytosis") association p(HGNC:HTT) - pmid:24563850 + pubmed:26751493 - act(p(HGNCGENEFAMILY:"Cytochrome P450 family 1")) increases a(CHEBI:"reactive nitrogen species") + bp(GO:"clathrin-dependent endocytosis") positiveCorrelation p(HGNC:MAPT) - pmid:24563850 + pubmed:26751493 - act(a(MESH:Peroxisomes)) increases a(CHEBI:radical) + bp(GO:"clathrin-dependent endocytosis") isA tloc(a(CONSO:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) - pmid:24563850 + pubmed:27260836 - act(a(MESH:Peroxisomes)) increases a(CHEBI:"reactive oxygen species") + bp(GO:"clathrin-dependent endocytosis") positiveCorrelation complex(p(CONSO:"AP-2 complex"), p(HGNCGENEFAMILY:"Clathrin subunits")) - pmid:24563850 + pubmed:26751493 - act(a(MESH:Peroxisomes)) increases a(CHEBI:"reactive nitrogen species") + bp(GO:"clathrin-dependent endocytosis") association p(CONSO:"Tau oligomers") - pmid:16566606 + pubmed:21214928 - a(CHEBI:"reactive nitrogen species") decreases act(a(MESH:Neurons)) + complex(p(HGNC:PLD1), p(HGNC:PSEN1)) increases p(HGNC:APP) + + - pmid:16566606 + pubmed:21214928 - a(CHEBI:"reactive nitrogen species") increases bp(GO:"neuron death") + complex(p(HGNC:APP), p(HGNC:LRP1)) increases a(CHEBI:amyloid-beta) - pmid:24563850 + pubmed:21214928 - bp(GO:"response to radiation") increases a(CHEBI:radical) + complex(p(HGNC:APP), p(HGNC:LRP1)) decreases p(HGNC:APP) - pmid:24563850 + pubmed:21214928 - a(MESH:"Air Pollution") increases a(CHEBI:radical) + complex(p(HGNC:APP), p(HGNC:LRP1B)) decreases a(CHEBI:amyloid-beta) - pmid:24563850 + pubmed:21214928 - bp(MESH:"Host-Pathogen Interactions") association a(CHEBI:radical) + complex(p(HGNC:APP), p(HGNC:LRP1B)) increases tloc(p(CONSO:CONSO00067), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + - pmid:24563850 + pubmed:21214928 - bp(HBP:"non-enzymatic protein modification") positiveCorrelation bp(GO:aging) + a(CHEBI:estrogen) decreases a(CHEBI:amyloid-beta) - pmid:24563850 + pubmed:19293145 - bp(HBP:"non-enzymatic protein modification") increases bp(HBP:misfolding) + a(CHEBI:estrogen) decreases act(a(CHEBI:amyloid-beta)) - pmid:24563850 + pubmed:11230871 - p(HGNCGENEFAMILY:"Small heat shock proteins") decreases path(MESH:"Protein Aggregation, Pathological") + a(CHEBI:estrogen) decreases act(a(CHEBI:amyloid-beta)) - pmid:24563850 + pubmed:21214928 - bp(GO:"post-translational protein modification") regulates p(HGNCGENEFAMILY:"Small heat shock proteins") + a(CHEBI:estrogen) increases tloc(p(CONSO:CONSO00067), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:24563850 + pubmed:19293145 - bp(GO:"cellular response to heat") increases p(HGNC:HSPA1A, loc(MESH:"Extracellular Space")) + a(CHEBI:estrogen) decreases act(g(CONSO:"APOE e4")) - + + + pubmed:11230871 + + a(CHEBI:estrogen) decreases path(MESH:"Alzheimer Disease") + + + + pubmed:21214928 + + act(p(HGNC:PRKCA)) increases tloc(p(CONSO:CONSO00067), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + - pmid:24563850 + pubmed:21214928 - p(HGNC:CAT) increases rxn(reactants(a(CHEBI:"hydrogen peroxide")), products(a(CHEBI:dioxygen), a(CHEBI:water))) + p(HGNC:PRKCA) increases tloc(p(CONSO:CONSO00067), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - + + + pubmed:21214928 + + p(HGNC:PRKCA) decreases a(CHEBI:amyloid-beta) + + + + pubmed:21214928 + + p(HGNC:PRKCA) directlyIncreases p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation", Ser, 655)) + + - pmid:29626319 + pubmed:22122372 - tloc(a(CHEBI:water), fromLoc(GO:"extracellular region"), toLoc(MESH:"Cerebrospinal Fluid")) decreases a(CHEBI:"amyloid-beta") + p(HGNC:PRKCA) increases p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Thr, 654)) - pmid:24563850 + pubmed:22122372 - p(HGNC:GPX1) increases rxn(reactants(a(CHEBI:"hydrogen peroxide")), products(a(CHEBI:water))) + p(HGNC:PRKCA) increases p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Thr, 668)) - + + + pubmed:22122372 + + p(HGNC:PRKCA) increases p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Ser, 665)) + - + + + pubmed:21214928 + + p(HGNC:RAB11A) decreases a(CHEBI:amyloid-beta) + - pmid:24563850 + pubmed:30027901 - complex(p(HGNC:MAF), p(HGNC:NFE2L2)) increases p(HGNC:NQO1) + p(HGNC:RAB11A) increases bp(GO:"synaptic vesicle recycling via endosome") - pmid:24563850 + pubmed:27181519 - complex(p(HGNC:MAF), p(HGNC:NFE2L2)) increases p(HGNC:HMOX1) + p(HGNC:RAB11A) association g(HGNC:C9orf72) - pmid:24563850 + pubmed:22122372 - complex(p(HGNC:MAF), p(HGNC:NFE2L2)) increases p(HGNC:GCLC) + p(CONSO:CONSO00078) association p(HGNC:APP) - pmid:24563850 + pubmed:22122372 - complex(p(HGNC:MAF), p(HGNC:NFE2L2)) increases p(FPLX:GST) + p(CONSO:CONSO00078) increases complex(p(HGNC:APP), p(HGNC:APP)) - pmid:24563850 + pubmed:22122372 - bp(GO:"protein oxidation") association bp(GO:aging) + p(CONSO:CONSO00078) increases complex(p(HGNC:APLP1), p(HGNC:APLP1)) - pmid:24563850 + pubmed:22122372 - bp(GO:"protein oxidation") association path(MESH:"Cardiovascular Diseases") + p(CONSO:CONSO00078) increases complex(p(HGNC:APLP2), p(HGNC:APLP2)) + + - pmid:24563850 + pubmed:22122372 - bp(GO:"protein oxidation") association bp(HP:Neurodegeneration) + p(CONSO:CONSO00079) association p(HGNC:APP) + + - pmid:24563850 + pubmed:22908190 - bp(GO:"protein oxidation") association path(MESH:Neoplasms) + complex(p(HGNC:APP), p(HGNC:APP)) increases bp(GO:endocytosis) + + + + + + + + - pmid:29024336 + pubmed:22122372 - bp(GO:"protein oxidation") increases tloc(p(MGI:Mapt), fromLoc(MESH:"Extracellular Space"), toLoc(GO:"multivesicular body")) + composite(p(MGI:Aplp1), p(MGI:Aplp2), p(MGI:App)) decreases path(MESH:"Perinatal Death") + + + + + + + + + + + + + + + + + + + + + + + + + + + + - pmid:24563850 + pubmed:22122372 - path(MESH:"Cardiovascular Diseases") association bp(GO:"protein oxidation") + p(HGNC:PSEN1, var("?")) increases p(HGNC:APP, frag("672_713")) - pmid:26195256 + pubmed:21722302 - path(MESH:"Cardiovascular Diseases") increases path(MESH:"Alzheimer Disease") + p(HGNC:PSEN1, var("?")) increases p(HGNC:APP, frag("672_713")) - pmid:19732809 + pubmed:30688256 - path(MESH:"Cardiovascular Diseases") negativeCorrelation p(MESH:Proteins, pmod(HBP:"O-GlcNAcylation")) + p(HGNC:PSEN1, var("?")) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:24563850 + pubmed:29758300 - bp(MESH:"Protein Carbonylation") increases a(MESH:"Protein Aggregates") + p(HGNC:PSEN1, var("?")) association path(MESH:"Alzheimer Disease") - pmid:24563850 + pubmed:22908190 - act(p(FPLX:PRDX)) decreases a(MESH:"Protein Aggregates") + p(HGNC:PSEN1, var("?")) increases path(MESH:"Alzheimer Disease") + + + pubmed:30688256 + + p(HGNC:PSEN1, var("?")) decreases bp(GO:autophagy) + + + + + pubmed:30688256 + + p(HGNC:PSEN1, var("?")) decreases act(a(MESH:Mitochondria)) + + + + + pubmed:30688256 + + p(HGNC:PSEN1, var("?")) decreases path(GO:mitophagy) + + - pmid:25036637 + pubmed:21722302 - p(INTERPRO:"Heat shock protein 70 family") directlyIncreases complex(p(HGNC:BAG2), p(HGNC:HSPA8), p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) + p(HGNC:PSEN1, var("?")) increases bp(MESH:Apoptosis) - pmid:25036637 + pubmed:21722302 - p(INTERPRO:"Heat shock protein 70 family") directlyIncreases complex(p(HGNC:HSF1), p(HGNC:TP53), p(INTERPRO:"Heat shock protein 70 family")) + p(HGNC:PSEN1, var("?")) decreases p(HGNC:ERN1) - pmid:21882945 + pubmed:21722302 - p(INTERPRO:"Heat shock protein 70 family") increases bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") + p(HGNC:PSEN1, var("?")) decreases r(HGNC:HSPA5) - pmid:21882945 + pubmed:21722302 - p(INTERPRO:"Heat shock protein 70 family") increases bp(GO:"proteasomal protein catabolic process") + p(HGNC:PSEN1, var("?")) decreases r(HGNC:XBP1) - pmid:21882945 + pubmed:21722302 - p(INTERPRO:"Heat shock protein 70 family") increases bp(GO:autophagy) + p(HGNC:PSEN1, var("?")) decreases bp(GO:"calcium ion homeostasis") - pmid:21882945 + pubmed:21722302 - p(INTERPRO:"Heat shock protein 70 family") increases act(p(HGNC:STUB1)) + p(HGNC:PSEN1, var("?")) increases tloc(a(CHEBI:"calcium cation"), fromLoc(GO:"endoplasmic reticulum"), toLoc(GO:cytoplasm)) - pmid:21882945 + pubmed:26968346 - p(INTERPRO:"Heat shock protein 70 family") increases bp(GO:"protein catabolic process") + p(HGNC:PSEN1, var("?")) decreases p(HGNCGENEFAMILY:"V-type ATPases") - pmid:21882945 + pubmed:26968346 - p(INTERPRO:"Heat shock protein 70 family") increases complex(a(GO:microtubule), p(HGNC:MAPT)) + p(HGNC:PSEN1, var("?")) negativeCorrelation bp(GO:"proton-transporting V-type ATPase complex assembly") - pmid:21882945 + pubmed:29758300 - act(p(INTERPRO:"Heat shock protein 70 family")) increases deg(p(HGNC:MAPT)) + p(HGNC:PSEN1, var("?")) decreases act(a(MESH:"Vacuolar Proton-Translocating ATPases")) - pmid:21882945 + pubmed:14556719 - act(p(INTERPRO:"Heat shock protein 70 family")) increases p(HGNC:MAPT) + p(HGNC:PSEN1, var("?")) association act(complex(GO:"gamma-secretase complex")) - pmid:18500754 + pubmed:14556719 - p(INTERPRO:"Heat shock protein 70 family") association complex(GO:microtubule) + p(HGNC:PSEN1, var("?")) increases a(CHEBI:amyloid-beta) - pmid:25036637 + pubmed:22908190 - p(INTERPRO:"Heat shock protein Hsp90 family") association p(INTERPRO:"NudC family") + p(HGNC:PSEN1, var("?")) decreases bp(GO:"lysosomal protein catabolic process") + + + pubmed:22908190 + + p(HGNC:PSEN1, var("?")) decreases act(a(CONSO:Neurites)) + + - pmid:25036637 + pubmed:22908190 - p(HGNC:DNAJC7) increases complex(p(HGNC:DNAJC7), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) + p(HGNC:PSEN1, var("?")) decreases bp(GO:"pH reduction") + + + pubmed:22908190 + + p(HGNC:PSEN1, var("?")) decreases act(a(MESH:Neurites)) + + + + + pubmed:24027553 + + p(HGNC:PSEN1, var("?")) increases path(MESH:"Alzheimer disease, familial, type 3") + + + + + pubmed:22122372 + + p(HGNC:PSEN2, var("?")) increases p(HGNC:APP, frag("672_713")) + + + + + pubmed:14556719 + + p(HGNC:PSEN2, var("?")) association act(complex(GO:"gamma-secretase complex")) + + + + + pubmed:14556719 + + p(HGNC:PSEN2, var("?")) increases a(CHEBI:amyloid-beta) + + @@ -121853,14 +123482,19 @@

Statements

- pmid:25036637 + pubmed:22122372 - p(HGNC:DNAJB6) increases complex(p(HGNC:DNAJB6), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) + a(MESH:"Receptors, Cell Surface") association p(HGNC:APP) - + + + pubmed:22122372 + + complex(p(HGNC:APP), p(HGNC:RTN4R)) regulates bp(CONSO:CONSO00073) + @@ -121868,44 +123502,57 @@

Statements

- pmid:25036637 + pubmed:22122372 - p(HGNC:HSPBP1) increases complex(p(HGNC:HSPBP1), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) + complex(p(HGNC:APP), p(HGNC:ITM2B)) regulates bp(CONSO:CONSO00073) - + + + pubmed:22122372 + + complex(p(CONSO:CONSO00078), p(CONSO:CONSO00079)) increases complex(p(HGNC:APLP1), p(HGNC:APP)) + - pmid:25036637 + pubmed:22122372 - p(HGNC:EDRF1) increases complex(p(HGNC:EDRF1), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) + complex(p(CONSO:CONSO00078), p(CONSO:CONSO00079)) increases complex(p(HGNC:APLP2), p(HGNC:APP)) - - - + + + pubmed:22122372 + + complex(p(CONSO:CONSO00078), p(CONSO:CONSO00079)) increases complex(p(HGNC:APP), p(HGNC:APP)) + - pmid:25036637 + pubmed:22122372 - p(HGNC:RNF41) increases complex(p(HGNC:RNF41), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) + complex(p(CONSO:CONSO00042, frag("?")), p(HGNC:TNFRSF21)) increases bp(GO:"neuron death") - + + + pubmed:22122372 + + complex(p(CONSO:CONSO00042, frag("?")), p(HGNC:TNFRSF21)) increases bp(GO:"synapse pruning") + @@ -121917,26 +123564,38 @@

Statements

- pmid:25036637 + pubmed:12428809 - p(HGNC:CDC37L1) directlyIncreases complex(p(HGNC:CDC37L1), p(INTERPRO:"Heat shock protein Hsp90 family")) + p(HGNC:KLC1) increases bp(GO:"anterograde axonal transport") - pmid:25036637 + pubmed:19491104 - p(HGNC:CDC37L1) directlyIncreases complex(p(HGNC:CDC37L1), p(HGNC:STIP1)) + act(p(HGNC:KLC1)) positiveCorrelation act(complex(GO:"kinesin complex")) - + + + pubmed:19491104 + + p(HGNC:KLC1) isA complex(GO:"kinesin complex") + + + + pubmed:19491104 + + p(HGNC:KLC1) association p(HGNC:MAPK8IP1) + + @@ -121947,9 +123606,9 @@

Statements

- pmid:25036637 + pubmed:22122372 - p(INTERPRO:"Cdc37, N-terminal domain") increases act(p(HGNC:CDC37)) + complex(p(CONSO:CONSO00071), p(HGNC:APBA1)) decreases a(CHEBI:amyloid-beta) @@ -121960,446 +123619,596 @@

Statements

- pmid:25036637 + pubmed:22122372 - complex(p(HGNC:CDC37L1), p(INTERPRO:"Cdc37, N-terminal domain")) regulates complex(p(HGNC:ARAF), p(HGNC:CDC37L1), p(INTERPRO:"Cdc37, N-terminal domain")) + p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Thr, 654)) association bp(CONSO:CONSO00073) - + + + pubmed:22122372 + + p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Thr, 654)) association act(p(CONSO:CONSO00071)) + + + + pubmed:22122372 + + p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Thr, 668)) association bp(CONSO:CONSO00073) + + - pmid:25036637 + pubmed:22122372 - p(INTERPRO:"Tetratricopeptide repeat") increases complex(a(MESH:"Tacrolimus Binding Proteins"), p(INTERPRO:"Heat shock protein Hsp90 family")) + p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Thr, 668)) association act(p(CONSO:CONSO00071)) - + + + pubmed:22122372 + + p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Ser, 665)) association bp(CONSO:CONSO00073) + - pmid:25036637 + pubmed:22122372 - p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:AURKB), p(HGNC:FKBP5)) + p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Ser, 665)) association act(p(CONSO:CONSO00071)) - pmid:25036637 + pubmed:22122372 - p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:CDK11A), p(HGNC:FKBP5)) + a(MESH:"JNK Mitogen-Activated Protein Kinases") increases p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Thr, 654)) - pmid:25036637 + pubmed:22122372 - p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:CDK1), p(HGNC:FKBP5)) + a(MESH:"JNK Mitogen-Activated Protein Kinases") increases p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Thr, 668)) - pmid:25036637 + pubmed:22122372 - p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:FKBP5), p(HGNC:IKBKG)) + a(MESH:"JNK Mitogen-Activated Protein Kinases") increases p(CONSO:CONSO00071, pmod(go:0006468 ! "protein phosphorylation", Ser, 665)) - pmid:25036637 + pubmed:22122372 - p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:CDK4), p(HGNC:FKBP5)) + complex(p(CONSO:CONSO00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:CD82) - pmid:25036637 + pubmed:22122372 - p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:FER), p(HGNC:FKBP5)) + complex(p(CONSO:CONSO00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:MME) - pmid:25036637 + pubmed:22122372 - p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:CHUK), p(HGNC:FKBP5)) + complex(p(CONSO:CONSO00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:TP53) - pmid:25036637 + pubmed:22122372 - p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:FKBP5), p(HGNC:RAF1)) + complex(p(CONSO:CONSO00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:GSK3B) - pmid:25036637 + pubmed:22122372 - p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:ABL2), p(HGNC:FKBP5)) + complex(p(CONSO:CONSO00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:EGFR) - pmid:25036637 + pubmed:22122372 - p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:ARAF), p(HGNC:FKBP5)) + complex(p(CONSO:CONSO00071), p(HGNC:APBB1), p(HGNC:KAT5)) regulates p(HGNC:LRP1) + + - pmid:25036637 + pubmed:21034527 - p(HGNC:FKBP5) association p(HGNC:CDC37) + p(HGNC:KAT5) isA p(INTERPRO:"Histone acetyltransferase domain, MYST-type") - pmid:25036637 + pubmed:22122372 - p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:AGO1), p(HGNC:FKBP5)) + act(p(HGNC:TP53)) increases bp(GO:"apoptotic process") + + - pmid:25036637 + pubmed:26293599 - p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:AGO2), p(HGNC:FKBP5)) + p(HGNC:TP53) association p(HGNC:BTG2) + + + + + + - pmid:25036637 + pubmed:22122372 - p(HGNC:FKBP5) association p(HGNC:EGLN1) + complex(p(CONSO:CONSO00071), p(HGNC:APBB1), p(HGNC:TFCP2)) increases p(HGNC:GSK3B) + + + + - pmid:25036637 + pubmed:22122372 - p(HGNC:FKBP5) association p(HGNC:PDCD2) + complex(p(CONSO:CONSO00071), p(HGNC:MAPK8IP1)) regulates p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation", Thr, 668)) - pmid:25036637 + pubmed:22122372 - p(HGNC:FKBP5) association p(HGNC:ANKMY2) + complex(p(CONSO:CONSO00071), p(HGNC:MAPK8IP1)) association bp(CONSO:CONSO00073) + + + + - pmid:25036637 + pubmed:19491104 - p(HGNC:FKBP5) increases complex(p(HGNC:FKBP5), p(HGNC:MCM4)) + act(p(HGNC:MAPK8IP1)) positiveCorrelation act(complex(GO:"kinesin complex")) - pmid:25036637 + pubmed:19491104 - p(HGNC:FKBP5) increases complex(p(HGNC:FKBP5), p(HGNC:MCMBP)) + p(HGNC:MAPK8IP1) isA complex(GO:"kinesin complex") - pmid:25036637 + pubmed:19491104 - p(HGNC:FKBP5) regulates bp(GO:"cellular response to DNA damage stimulus") + p(HGNC:MAPK8IP1) association p(HGNC:KLC1) - pmid:21882945 + pubmed:21034527 - p(HGNC:FKBP5) regulates complex(a(GO:microtubule), p(HGNC:MAPT)) + p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation", Thr, 668)) increases complex(p(HGNC:APBB1), p(INTERPRO:"Amyloidogenic glycoprotein, intracellular domain, conserved site")) - pmid:21882945 + pubmed:27094130 - p(HGNC:FKBP5) increases complex(p(FPLX:HSP90), p(HGNC:MAPT)) + p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation", Thr, 668)) association bp(CONSO:"APP processing") - pmid:20071522 + pubmed:27094130 - p(HGNC:FKBP5) positiveCorrelation complex(p(FPLX:HSP90), p(HGNC:MAPT)) + p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation", Thr, 668)) regulates tloc(p(HGNC:APP, frag("672_711")), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:21882945 + pubmed:27094130 - p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:FKBP5), p(HGNC:MAPT)) + p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation", Thr, 668)) regulates tloc(p(HGNC:APP, frag("672_713")), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:20071522 + pubmed:22122372 - p(HGNC:FKBP5) isA complex(p(HGNC:FKBP5), p(HGNC:MAPT)) + complex(p(CONSO:CONSO00071), p(HGNC:NAE1)) increases bp(GO:"protein neddylation") - pmid:21882945 + pubmed:22122372 - p(HGNC:FKBP5) positiveCorrelation bp(GO:aging) + complex(p(CONSO:CONSO00071), p(HGNC:NAE1)) decreases p(HGNC:CTNNB1) - pmid:21882945 + pubmed:22122372 - p(HGNC:FKBP5) increases p(HGNC:MAPT) + complex(p(CONSO:CONSO00071), p(HGNC:NAE1)) increases bp(GO:"apoptotic process") + + + + - pmid:20071522 + url:"https://www.ncbi.nlm.nih.gov/clinvar/RCV000019448/" - p(HGNC:FKBP5) increases p(HGNC:MAPT) + g(HGNC:APOE, var("c.388T>C")) equivalentTo g(DBSNP:rs429358) - pmid:21882945 + url:"https://www.ncbi.nlm.nih.gov/clinvar/RCV000019448/" - p(HGNC:FKBP5) increases p(HGNC:MAPT, pmod(Ph)) + g(HGNC:APOE, var("c.388T>C")) transcribedTo r(HGNC:APOE, var("r.388u>c")) + + + + - pmid:29311797 + pubmed:19734902 - p(HGNC:FKBP5) isA a(MESH:Immunophilins) + g(HGNC:APOE) association path(MESH:"Alzheimer Disease") - pmid:20071522 + pubmed:19734903 - p(HGNC:FKBP5) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) + g(HGNC:APOE) association path(MESH:"Alzheimer Disease") - pmid:20071522 + pubmed:20460622 - p(HGNC:FKBP5) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 199)) + g(HGNC:APOE) association path(MESH:"Alzheimer Disease") - pmid:20071522 + pubmed:20885792 - p(HGNC:FKBP5) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) + g(HGNC:APOE) association path(MESH:"Alzheimer Disease") - pmid:20071522 + pubmed:17474819 - p(HGNC:FKBP5) negativeCorrelation complex(p(HGNC:AHSA1), p(HGNC:MAPT)) + g(HGNC:APOE) association path(MESH:"Alzheimer Disease") - pmid:20071522 + pubmed:21123754 - p(HGNC:FKBP5) decreases complex(p(HGNC:MAPT), p(HGNC:PTGES3)) + g(HGNC:APOE) association path(MESH:"Alzheimer Disease") - pmid:20071522 + pubmed:10936883 - p(HGNC:FKBP5) increases bp(GO:"microtubule polymerization") + g(HGNC:APOE) association path(MESH:"Alzheimer Disease") - + + + pubmed:19293145 + + g(HGNC:APOE) positiveCorrelation path(MESH:"Alzheimer Disease") + - + + + pubmed:19734902 + + g(HGNC:APOE) association g(DBSNP:rs2075650) + - + + + pubmed:20460622 + + g(HGNC:APOE) association g(DBSNP:rs2075650) + - + + + pubmed:20885792 + + g(HGNC:APOE) association g(DBSNP:rs2075650) + - + + + pubmed:19734903 + + g(HGNC:APOE) association g(DBSNP:rs11136000) + - pmid:29686391 + pubmed:17474819 - p(HGNC:CDK4) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + g(HGNC:APOE) association g(DBSNP:rs4420638) - + + + pubmed:21123754 + + g(HGNC:APOE) association g(DBSNP:rs429358) + - + + + pubmed:21123754 + + g(HGNC:APOE) association g(DBSNP:rs429358) + - + + + pubmed:23419831 + + g(HGNC:APOE) association g(DBSNP:rs429358) + - + + + pubmed:21123754 + + g(HGNC:APOE) association g(DBSNP:rs439401) + + + + pubmed:23562540 + + g(HGNC:APOE) association g(DBSNP:rs769449) + + - pmid:26631930 + pubmed:19293145 - p(HGNC:ABL2) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 394)) + g(HGNC:APOE) increases p(HGNC:APOE) - + + + pubmed:19293145 + + g(HGNC:APOE) association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + - + + + pubmed:19293145 + + g(HGNC:APOE) negativeCorrelation p(HGNC:CHAT) + - + + + pubmed:19293145 + + g(HGNC:APOE) negativeCorrelation act(a(CHEBI:tacrine)) + - + + + pubmed:19293145 + + g(HGNC:APOE) causesNoChange complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) + - + + + pubmed:31413141 + + g(HGNC:APOE) negativeCorrelation a(CHEBI:"amyloid-beta polypeptide 42") + - + + + url:"https://www.ncbi.nlm.nih.gov/clinvar/RCV000019448/" + + g(DBSNP:rs429358) equivalentTo g(HGNC:APOE, var("c.388T>C")) + - + + + pubmed:21123754 + + g(DBSNP:rs429358) association path(MESH:"Alzheimer Disease") + - + + + pubmed:21123754 + + g(DBSNP:rs429358) association g(HGNC:APOE) + - + + + pubmed:21123754 + + g(DBSNP:rs429358) association g(HGNC:APOE) + - + + + pubmed:23419831 + + g(DBSNP:rs429358) association g(HGNC:APOE) + - + + + url:"https://www.ncbi.nlm.nih.gov/clinvar/RCV000019448/" + + r(HGNC:APOE, var("r.388u>c")) translatedTo p(HGNC:APOE, var("p.Cys130Arg")) + @@ -122407,449 +124216,506 @@

Statements

- pmid:25036637 + pubmed:19940480 - p(HGNC:AGO1) directlyIncreases complex(p(HGNC:AGO1), p(INTERPRO:"Heat shock protein Hsp90 family")) + p(HGNC:APOE, var("p.Cys130Arg")) positiveCorrelation a(NIFT:"Brain volume") - pmid:25036637 + pubmed:19940480 - p(HGNC:AGO1) directlyIncreases complex(p(HGNC:AGO2), p(INTERPRO:"Heat shock protein Hsp90 family")) + p(HGNC:APOE, var("p.Cys130Arg")) negativeCorrelation a(NIFT:"Hippocampus volume") - pmid:25036637 + pubmed:19940480 - p(HGNC:AGO1) positiveCorrelation bp(GO:"ribonucleoprotein complex biogenesis") + p(HGNC:APOE, var("p.Cys130Arg")) negativeCorrelation a(NIFT:"Ventricular volume") - - - pmid:25036637 + pubmed:21460840 - p(HGNC:AGO2) positiveCorrelation bp(GO:"ribonucleoprotein complex biogenesis") + g(HGNC:CR1) association g(DBSNP:rs3818361) - + + + pubmed:19734903 + + g(HGNC:CR1) association g(DBSNP:rs3818361) + - + + + pubmed:21460841 + + g(HGNC:CR1) association path(MESH:"Alzheimer Disease") + - pmid:25036637 + pubmed:21460841 - bp(GO:"ribonucleoprotein complex biogenesis") positiveCorrelation p(HGNC:AGO1) + g(HGNC:CR1) association g(DBSNP:rs6701713) - pmid:25036637 + pubmed:21460841 - bp(GO:"ribonucleoprotein complex biogenesis") positiveCorrelation p(HGNC:AGO2) + g(HGNC:CR1) association g(DBSNP:rs6701713) - pmid:25036637 + pubmed:24162737 - p(HGNC:EGLN1) association p(HGNC:FKBP5) + g(HGNC:CR1) association g(DBSNP:rs6656401) - pmid:25036637 + pubmed:19734903 - p(HGNC:EGLN1) association p(INTERPRO:"Zinc finger, MYND-type") + g(HGNC:CR1) association g(DBSNP:rs6656401) - pmid:25036637 + pubmed:" 26517285" - p(INTERPRO:"Zinc finger, MYND-type") association p(HGNC:EGLN1) + g(HGNC:CR1) association bp(GO:"immune response") - pmid:25036637 + pubmed:22244847 - p(INTERPRO:"Zinc finger, MYND-type") increases complex(p(HGNC:EGLN1), p(INTERPRO:"Heat shock protein Hsp90 family")) + g(DBSNP:rs3818361) increases bp(GO:"long-term synaptic depression") - pmid:25036637 + pubmed:23022416 - p(INTERPRO:"Zinc finger, MYND-type") association p(HGNC:PDCD2) + g(DBSNP:rs3818361) positiveCorrelation path(MESH:"Alzheimer Disease") + + - pmid:25036637 + pubmed:23022416 - p(INTERPRO:"Zinc finger, MYND-type") increases complex(p(HGNC:PDCD2), p(INTERPRO:"Heat shock protein Hsp90 family")) + g(DBSNP:rs3818361) negativeCorrelation p(HGNC:APP, frag("672_713")) - pmid:25036637 + pubmed:21460840 - p(INTERPRO:"Zinc finger, MYND-type") association p(HGNC:ANKMY2) + g(DBSNP:rs3818361) association g(HGNC:CR1) - pmid:25036637 + pubmed:19734903 - p(INTERPRO:"Zinc finger, MYND-type") increases complex(p(HGNC:ANKMY2), p(INTERPRO:"Heat shock protein Hsp90 family")) + g(DBSNP:rs3818361) association g(HGNC:CR1) - - - - - pmid:25036637 + pubmed:25468261 - p(HGNC:PDCD2) association p(HGNC:FKBP5) + a(CONSO:"CDR - Sum of Boxes") positiveCorrelation p(HGNC:APP, frag("672_713")) - pmid:25036637 + pubmed:25468261 - p(HGNC:PDCD2) association p(INTERPRO:"Zinc finger, MYND-type") + a(CONSO:"CDR - Sum of Boxes") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - - - - - pmid:25036637 + pubmed:23727081 - p(HGNC:ANKMY2) association p(HGNC:FKBP5) + a(CONSO:"CDR - Sum of Boxes") positiveCorrelation composite(g(DBSNP:rs1868402), g(DBSNP:rs3785883)) - pmid:25036637 + pubmed:23138174 - p(HGNC:ANKMY2) association p(INTERPRO:"Zinc finger, MYND-type") + a(CONSO:"CDR - Sum of Boxes") positiveCorrelation a(NIFT:"Alzheimer questionnaire") - - - - - - - - - + + + pubmed:16254429 + + a(CONSO:"CDR - Sum of Boxes") positiveCorrelation a(NIFT:"Clinical dementia rating") + - pmid:25036637 + pubmed:25429309 - p(HGNC:MCMBP) increases bp(GO:"DNA replication initiation") + a(CONSO:"CDR - Sum of Boxes") positiveCorrelation a(NIFT:"Dopamine transporter scan") - pmid:25036637 + pubmed:23175194 - p(HGNC:MCMBP) increases bp(GO:"replication fork progression beyond termination site") + a(CONSO:"CDR - Sum of Boxes") negativeCorrelation a(NIFT:"Hippocampus volume") - pmid:25036637 + pubmed:26043140 - p(HGNC:MCMBP) increases complex(p(HGNC:MCM2), p(HGNC:MCMBP)) + a(CONSO:"CDR - Sum of Boxes") association a(EFO:"cognitive decline measurement") - pmid:25036637 + pubmed:25542982 - p(HGNC:MCMBP) increases complex(p(HGNC:MCM3), p(HGNC:MCMBP)) + a(CONSO:"CDR - Sum of Boxes") negativeCorrelation a(NIFT:"3-HPMA/Cre ratio") - pmid:25036637 + pubmed:24242746 - p(HGNC:MCMBP) increases complex(p(HGNC:MCM4), p(HGNC:MCMBP)) + a(CONSO:"CDR - Sum of Boxes") positiveCorrelation p(HGNC:NEFL) - pmid:25036637 + pubmed:25429309 - p(HGNC:MCMBP) increases complex(p(HGNC:MCM5), p(HGNC:MCMBP)) + a(CONSO:"CDR - Sum of Boxes") negativeCorrelation p(HGNC:SLC6A3) - pmid:25036637 + pubmed:23775979 - p(HGNC:MCMBP) increases complex(p(HGNC:MCM6), p(HGNC:MCMBP)) + a(CONSO:"CDR - Sum of Boxes") negativeCorrelation complex(a(InChI:"InChI=1S/C22H21NO3/c1-17(24)23(16-18-10-6-8-14-21(18)25-2)20-13-7-9-15-22(20)26-19-11-4-3-5-12-19/h3-15H,16H2,1-2H3/i2-1"), p(HGNC:TSPO)) - pmid:25036637 + pubmed:25566378 - p(HGNC:MCMBP) increases complex(p(HGNC:MCM7), p(HGNC:MCMBP)) + a(CONSO:"CDR - Sum of Boxes") negativeCorrelation path(GO:"short-term memory") - pmid:25036637 + pubmed:18346821 - p(HGNC:MCMBP) increases complex(p(HGNC:FKBP5), p(HGNC:MCMBP)) + a(CONSO:"CDR - Sum of Boxes") positiveCorrelation a(MESH:"2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole") - - - + + + pubmed:25024322 + + a(CONSO:"CDR - Sum of Boxes") positiveCorrelation p(HGNC:CHI3L1) + - + + + pubmed:23727081 + + composite(g(DBSNP:rs1868402), g(DBSNP:rs3785883)) positiveCorrelation a(CONSO:"CDR - Sum of Boxes") + - + + + pubmed:23727081 + + g(DBSNP:rs1868402) causesNoChange a(CONSO:"CDR - Sum of Boxes") + - + + + pubmed:23727081 + + g(DBSNP:rs3785883) causesNoChange a(CONSO:"CDR - Sum of Boxes") + - + + + pubmed:27084223 + + a(NIFT:"Fractional anisotropy") negativeCorrelation a(NIFT:"Clinical dementia rating") + - + + + pubmed:21543606 + + a(NIFT:"Fractional anisotropy") decreases a(NIFT:"White matter") + - + + + pubmed:21543606 + + a(NIFT:"Fractional anisotropy") association bp(GO:"regulation of lipid metabolic process") + - + + + pubmed:27084223 + + a(NIFT:"Clinical dementia rating") negativeCorrelation a(NIFT:"Fractional anisotropy") + - pmid:23702978 + pubmed:25207744 - bp(GO:"cellular response to DNA damage stimulus") increases complex(GO:ripoptosome) + a(NIFT:"Clinical dementia rating") positiveCorrelation a(NIFT:"Heidelberg edge perimetry") - pmid:25036637 + pubmed:26682680 - p(HGNC:FKBP8) increases complex(p(HGNC:FKBP8), p(HGNC:PDCL)) + a(NIFT:"Clinical dementia rating") positiveCorrelation path(MESH:Hallucinations) - pmid:25036637 + pubmed:25304332 - p(HGNC:FKBP8) association bp(GO:"G protein-coupled receptor signaling pathway") + a(NIFT:"Clinical dementia rating") positiveCorrelation p(HGNC:SERPINE1) - pmid:29311797 + pubmed:23567436 - p(HGNC:FKBP8) isA a(MESH:Immunophilins) + a(NIFT:"Clinical dementia rating") positiveCorrelation g(DBSNP:rs3853248) - + + + pubmed:23567436 + + a(NIFT:"Clinical dementia rating") positiveCorrelation g(DBSNP:rs22334693) + - pmid:25036637 + pubmed:23567436 - p(HGNC:PDCL) association p(INTERPRO:"G-protein, gamma subunit") + a(NIFT:"Clinical dementia rating") positiveCorrelation g(DBSNP:rs9340799) - pmid:25036637 + pubmed:23567436 - p(HGNC:PDCL) isA a(MESH:"Molecular Chaperones") + a(NIFT:"Clinical dementia rating") positiveCorrelation g(DBSNP:rs9397456) - pmid:25036637 + pubmed:23567436 - bp(GO:"G protein-coupled receptor signaling pathway") association p(HGNC:FKBP8) + a(NIFT:"Clinical dementia rating") positiveCorrelation g(DBSNP:rs1801132) - pmid:25036637 + pubmed:23567436 - p(INTERPRO:"G-protein, gamma subunit") association p(HGNC:PDCL) + a(NIFT:"Clinical dementia rating") positiveCorrelation g(DBSNP:rs2179922) - pmid:25036637 + pubmed:23567436 - p(HGNC:FKBP6) increases complex(p(HGNC:FKBP6), p(HGNC:OSBP)) + a(NIFT:"Clinical dementia rating") positiveCorrelation g(DBSNP:rs932477) - pmid:29311797 + pubmed:23567436 - p(HGNC:FKBP6) isA a(MESH:Immunophilins) + a(NIFT:"Clinical dementia rating") positiveCorrelation g(DBSNP:rs9341016) - + + + pubmed:16254429 + + a(NIFT:"Clinical dementia rating") positiveCorrelation a(CONSO:"CDR - Sum of Boxes") + - pmid:25036637 + pubmed:25116835 - a(HBP:"OSW-1") decreases complex(p(HGNC:FKBP6), p(HGNC:OSBP)) + a(NIFT:"Clinical dementia rating") negativeCorrelation p(HGNC:DYRK1A) - pmid:25036637 + pubmed:24961945 - p(INTERPRO:"BAG domain") regulates act(p(INTERPRO:"Heat shock protein 70 family")) + a(NIFT:"Clinical dementia rating") positiveCorrelation a(CHEBI:"manganese(2+)") - + + + pubmed:25678559 + + a(NIFT:"Clinical dementia rating") positiveCorrelation p(HGNC:APP) + - pmid:25036637 + pubmed:27018940 - p(HGNC:LTN1) association bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") + p(HGNC:NRGN) positiveCorrelation a(NIFT:"Brain atrophy") - + + + pubmed:27018940 + + a(NIFT:"Brain atrophy") positiveCorrelation p(HGNC:NRGN) + @@ -122857,62 +124723,65 @@

Statements

- pmid:25036637 + pubmed:23092889 - p(HGNC:BAG5) increases complex(p(HGNC:BAG5), p(HGNC:MAD1L1)) + p(HGNC:MAPK1) association p(HGNC:EIF2AK2) - pmid:25036637 + pubmed:30515821 - p(HGNC:BAG5) increases complex(p(HGNC:BAG5), p(HGNC:MAD2L1)) + p(HGNC:MAPK1) increases p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 616)) - - - + + + pubmed:30515821 + + p(HGNC:MAPK1) association path(MESH:"Mitochondrial Dynamics") + - pmid:25036637 + pubmed:30515821 - p(HGNC:BAG4) increases complex(p(HGNC:BAG4), p(HGNC:DCP1A)) + p(HGNC:MAPK1) association path(DOID:"neurodegenerative disease") - pmid:25036637 + pubmed:19126755 - p(HGNC:BAG4) increases complex(p(HGNC:BAG4), p(HGNC:EDC3)) + act(p(HGNC:MAPK1)) association bp(MESH:"Neuronal Plasticity") - pmid:25036637 + pubmed:22530628 - p(HGNC:BAG4) increases complex(p(HGNC:BAG4), p(HGNC:DDX6)) + p(HGNC:MAPK1) increases bp(MESH:"Neuronal Plasticity") - pmid:25036637 + pubmed:19126755 - p(HGNC:BAG4) negativeCorrelation complex(GO:"P-body") + act(p(HGNC:MAPK1)) association path(MESH:"Tobacco Use Disorder") @@ -122921,340 +124790,345 @@

Statements

- pmid:25036637 + pubmed:19293145 - p(HGNC:BAG4) directlyIncreases complex(p(HGNC:BAG4), p(HGNC:HSPB1)) + act(p(HGNC:MAPK1)) increases bp(GO:"apoptotic process") + + - pmid:25036637 + pubmed:22530628 - p(HGNC:BAG4) directlyIncreases complex(p(HGNC:BAG4), p(HGNC:DCP1B)) + p(HGNC:MAPK1) increases bp(GO:cognition) - + + + pubmed:22530628 + + p(HGNC:MAPK1) increases bp(GO:"learning or memory") + - pmid:25036637 + pubmed:22530628 - p(HGNC:DCP1A) association bp(GO:"cellular protein catabolic process") + act(p(HGNC:MAPK1)) increases p(HGNC:ARC) - pmid:25036637 + pubmed:22530628 - p(HGNC:DCP1A) association bp(GO:"gene silencing") + p(HGNC:MAPK1) increases p(HGNC:ARC) - - - pmid:25036637 + pubmed:26968346 - p(HGNC:EDC3) association bp(GO:"cellular protein catabolic process") + act(p(HGNC:MAPK1), ma(go:0016301 ! "kinase activity")) increases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation", Ser, 142)) - pmid:25036637 + pubmed:27299292 - p(HGNC:EDC3) association bp(GO:"gene silencing") + act(p(HGNC:MAPK1), ma(go:0016301 ! "kinase activity")) increases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation", Ser, 142)) - - - - - pmid:25036637 + pubmed:27299292 - p(HGNC:DDX6) association bp(GO:"cellular protein catabolic process") + act(p(HGNC:MAPK1), ma(go:0016301 ! "kinase activity")) increases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation", Ser, 142)) - pmid:25036637 + pubmed:26968346 - p(HGNC:DDX6) association bp(GO:"gene silencing") + act(p(HGNC:MAPK1), ma(go:0016301 ! "kinase activity")) increases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation", Ser, 211)) - pmid:25036637 + pubmed:27299292 - complex(GO:"P-body") negativeCorrelation p(HGNC:BAG4) + act(p(HGNC:MAPK1), ma(go:0016301 ! "kinase activity")) increases p(HGNC:TFEB, loc(GO:cytoplasm)) - pmid:25036637 + pubmed:28784767 - complex(GO:"P-body") association p(HGNC:BAG4, var("p.Asp424Ala")) + act(p(HGNC:MAPK1)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) - pmid:25036637 + pubmed:28784767 - complex(GO:"P-body") negativeCorrelation p(HGNC:BAG4, var("p.Asp424Ala")) + act(p(HGNC:MAPK1)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) - pmid:27181519 + pubmed:25207744 - complex(GO:"P-body") isA complex(GO:"ribonucleoprotein granule") + a(NIFT:"Heidelberg edge perimetry") positiveCorrelation a(NIFT:"Clinical dementia rating") + + + + - pmid:27181519 + pubmed:25171717 - complex(GO:"P-body") regulates a(MESH:"RNA, Messenger") + p(HGNC:MAPT, frag("421_*")) causesNoChange a(CONSO:"CDR - Sum of Boxes") - pmid:27181519 + pubmed:25171717 - complex(GO:"P-body") association bp(GO:"RNA catabolic process") + p(HGNC:MAPT, frag("421_*")) causesNoChange a(NIFT:"Mini mental state exam") - pmid:27181519 + pubmed:25171717 - complex(GO:"P-body") regulates a(MESH:RNA) + p(HGNC:MAPT, frag("421_*")) causesNoChange a(NIFT:"Alzheimers disease assessment scale") + + + + - pmid:25036637 + pubmed:25171717 - p(HGNC:BAG4, var("p.Asp424Ala")) decreases complex(p(HGNC:BAG4, var("p.Asp424Ala")), p(INTERPRO:"Heat shock protein 70 family")) + p(HGNC:MAPT, frag("152_*")) causesNoChange a(CONSO:"CDR - Sum of Boxes") - pmid:25036637 + pubmed:25171717 - p(HGNC:BAG4, var("p.Asp424Ala")) association complex(GO:"P-body") + p(HGNC:MAPT, frag("152_*")) causesNoChange a(NIFT:"Mini mental state exam") - pmid:25036637 + pubmed:25171717 - p(HGNC:BAG4, var("p.Asp424Ala")) negativeCorrelation complex(GO:"P-body") + p(HGNC:MAPT, frag("152_*")) causesNoChange a(NIFT:"Alzheimers disease assessment scale") - - - - - pmid:25036637 + pubmed:26682680 - a(PUBCHEM:23624255) decreases act(p(INTERPRO:"Heat shock protein Hsp90 family")) + a(NIFT:"Mini mental state exam") positiveCorrelation path(MESH:Hallucinations) - pmid:25036637 + pubmed:25304332 - a(PUBCHEM:23624255) decreases complex(p(HGNC:HSP90AB1), p(HGNC:RPAP3)) + a(NIFT:"Mini mental state exam") positiveCorrelation p(HGNC:SERPINE1) - pmid:25036637 + pubmed:24961945 - a(PUBCHEM:23624255) decreases complex(p(HGNC:HSP90AB1), p(HGNC:SUGT1)) + a(NIFT:"Mini mental state exam") positiveCorrelation a(CHEBI:"manganese(2+)") - pmid:25036637 + pubmed:25542982 - a(PUBCHEM:23624255) decreases complex(p(HGNC:HSP90AB1), p(HGNC:SUGT1)) + a(NIFT:"Mini mental state exam") negativeCorrelation a(NIFT:"3-HPMA/Cre ratio") - pmid:25036637 + pubmed:23775979 - a(PUBCHEM:23624255) decreases complex(p(HGNC:FKBP4), p(HGNC:HSP90AB1)) + a(NIFT:"Mini mental state exam") negativeCorrelation complex(a(InChI:"InChI=1S/C22H21NO3/c1-17(24)23(16-18-10-6-8-14-21(18)25-2)20-13-7-9-15-22(20)26-19-11-4-3-5-12-19/h3-15H,16H2,1-2H3/i2-1"), p(HGNC:TSPO)) - pmid:25036637 + pubmed:25566378 - a(PUBCHEM:23624255) decreases complex(p(HGNC:FKBP4), p(HGNC:HSP90AB1)) + a(NIFT:"Mini mental state exam") positiveCorrelation path(GO:"short-term memory") - pmid:25036637 + pubmed:21504134 - a(PUBCHEM:23624255) increases complex(p(HGNC:BAG3), p(HGNC:HSPA8)) + a(NIFT:"Mini mental state exam") positiveCorrelation a(NIFT:"Cortical Thinning") - pmid:25036637 + pubmed:25678559 - a(PUBCHEM:23624255) increases complex(p(HGNC:BAG1), p(HGNC:HSPA8)) + a(NIFT:"Mini mental state exam") negativeCorrelation p(HGNC:APP) - pmid:25036637 + pubmed:10449594 - a(PUBCHEM:23624255) increases complex(p(HGNC:BAG4), p(HGNC:HSPA8)) + a(NIFT:"Mini mental state exam") positiveCorrelation a(NIFT:Hypoperfusion) - pmid:25036637 + pubmed:26682680 - a(PUBCHEM:23624255) increases complex(p(HGNC:BAG5), p(HGNC:HSPA8)) + path(MESH:Hallucinations) positiveCorrelation a(NIFT:"Clinical dementia rating") - pmid:25036637 + pubmed:26682680 - a(PUBCHEM:23624255) decreases complex(p(HGNC:FKBP5), p(HGNC:HSP90AB1)) + path(MESH:Hallucinations) positiveCorrelation a(NIFT:"Mini mental state exam") - pmid:25036637 + pubmed:30061532 - a(PUBCHEM:23624255) decreases complex(p(HGNC:HSPA8), p(HGNC:SUGT1)) + path(MESH:Hallucinations) negativeCorrelation bp(GO:autophagy) - pmid:25036637 + pubmed:24511233 - a(PUBCHEM:23624255) decreases complex(p(HGNC:FKBP4), p(HGNC:HSPA8)) + path(MESH:Hallucinations) association path(MESH:Schizophrenia) - pmid:25036637 + pubmed:24511233 - a(PUBCHEM:23624255) decreases complex(p(HGNC:FKBP5), p(HGNC:HSPA8)) + path(MESH:Hallucinations) biomarkerFor path(MESH:Schizophrenia) - pmid:25036637 + pubmed:19721446 - a(PUBCHEM:23624255) increases complex(p(HGNC:HSP90AB1), p(HGNC:SIRT6)) + path(MESH:Hallucinations) association path(MESH:Schizophrenia) - pmid:25036637 + pubmed:25304332 - a(PUBCHEM:23624255) increases complex(p(HGNC:AR), p(HGNC:HSP90AB1)) + p(HGNC:SERPINE1) positiveCorrelation a(NIFT:"Clinical dementia rating") - pmid:25036637 + pubmed:25304332 - a(PUBCHEM:23624255) increases complex(p(HGNC:HSPA8), p(HGNC:SIRT6)) + p(HGNC:SERPINE1) positiveCorrelation a(NIFT:"Mini mental state exam") - pmid:25036637 + pubmed:23138174 - a(PUBCHEM:23624255) increases complex(p(HGNC:AR), p(HGNC:HSPA8)) + a(NIFT:"Alzheimer questionnaire") positiveCorrelation a(CONSO:"CDR - Sum of Boxes") @@ -123263,437 +125137,493 @@

Statements

+ + + + + + + + + + + + - pmid:25036637 + pubmed:25570489 - p(HGNC:RPAP3) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5), p(HGNC:RPAP3)) + p(HGNC:ESR1) association a(NIFT:"Ventricular expansion") - pmid:25036637 + pubmed:25570489 - p(HGNC:RPAP3) directlyIncreases complex(p(HGNC:RPAP3), p(HGNC:RPAP3)) + p(HGNC:ESR1) association a(NIFT:"Hippocampal atrophy") - pmid:25036637 + pubmed:26837465 - p(HGNC:RPAP3) directlyIncreases complex(p(FPLX:HSP90), p(HGNC:RPAP3)) + p(HGNC:ESR1) association complex(GO:"neurofibrillary tangle") + + + pubmed:26837465 + + p(HGNC:ESR1) association complex(GO:"neurofibrillary tangle") + + + + + + - pmid:25036637 + pubmed:23567436 - p(HGNC:SUGT1) directlyIncreases complex(p(HGNC:SUGT1), p(INTERPRO:"Leucine-rich repeat domain superfamily")) + g(DBSNP:rs3853248) positiveCorrelation a(NIFT:"Clinical dementia rating") - pmid:25036637 + pubmed:23567436 - p(HGNC:SUGT1) directlyIncreases complex(p(HGNC:SUGT1), p(INTERPRO:"Leucine-rich repeat")) + g(DBSNP:rs22334693) positiveCorrelation a(NIFT:"Clinical dementia rating") - + + + pubmed:23567436 + + g(DBSNP:rs9340799) positiveCorrelation a(NIFT:"Clinical dementia rating") + - pmid:29311797 + pubmed:23567436 - p(HGNC:FKBP4) isA a(MESH:Immunophilins) + g(DBSNP:rs9397456) positiveCorrelation a(NIFT:"Clinical dementia rating") - pmid:26631930 + pubmed:23567436 - p(HGNC:FKBP4) increases a(HBP:"Tau aggregates") + g(DBSNP:rs1801132) positiveCorrelation a(NIFT:"Clinical dementia rating") + + + pubmed:23567436 + + g(DBSNP:rs2179922) positiveCorrelation a(NIFT:"Clinical dementia rating") + + - pmid:26903089 + pubmed:23567436 - act(p(HGNC:FKBP4)) association p(HBP:"VQIVYK motif") + g(DBSNP:rs932477) positiveCorrelation a(NIFT:"Clinical dementia rating") - + + + pubmed:23567436 + + g(DBSNP:rs9341016) positiveCorrelation a(NIFT:"Clinical dementia rating") + - + + + pubmed:22701578 + + a(NIFT:"Rey auditory verbal learning test") negativeCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + - + + + pubmed:22701578 + + a(NIFT:"Rey auditory verbal learning test") negativeCorrelation a(NIFT:"Ratio phospho tau to abeta 42 test") + - + + + pubmed:22701578 + + a(NIFT:"Ratio phospho tau to abeta 42 test") negativeCorrelation a(NIFT:"Rey auditory verbal learning test") + - + + + pubmed:25429309 + + a(NIFT:"Dopamine transporter scan") positiveCorrelation a(CONSO:"CDR - Sum of Boxes") + - + + + pubmed:25116835 + + p(HGNC:DYRK1A) negativeCorrelation a(NIFT:"Clinical dementia rating") + - + + + pubmed:25116835 + + p(HGNC:DYRK1A) negativeCorrelation p(HGNC:MAPT) + - + + + pubmed:22110360 + + p(HGNC:DYRK1A) association p(HGNC:MAPT) + - + + + pubmed:25116835 + + p(HGNC:DYRK1A) negativeCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + - + + + pubmed:22110360 + + p(HGNC:DYRK1A) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + - + + + pubmed:22110360 + + p(HGNC:DYRK1A) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + - + + + pubmed:25116835 + + p(HGNC:DYRK1A) causesNoChange p(HGNC:APP, frag("672_713")) + - + + + pubmed:21156028 + + p(HGNC:DYRK1A) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 212)) + - + + + pubmed:21156028 + + p(HGNC:DYRK1A) increases p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation", Thr, 688)) + - pmid:21882945 + pubmed:22110360 - p(HGNC:BAG2) directlyIncreases complex(p(HGNC:BAG2), p(HGNC:MAPT), p(INTERPRO:"Heat shock protein 70 family")) + p(HGNC:DYRK1A) increases p(FPLX:NFAT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:21882945 + pubmed:22110360 - p(HGNC:BAG2) association deg(p(HGNC:MAPT, pmod(Ph))) + p(HGNC:DYRK1A) increases p(FPLX:CREB, pmod(go:0006468 ! "protein phosphorylation")) - pmid:21882945 + pubmed:22110360 - p(HGNC:BAG2) decreases act(p(HGNC:STUB1)) + act(p(HGNC:DYRK1A)) increases p(FPLX:CREB, pmod(go:0006468 ! "protein phosphorylation")) - pmid:21882945 + pubmed:22110360 - p(HGNC:BAG2) decreases bp(GO:"protein ubiquitination") + p(HGNC:DYRK1A) increases p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation")) - pmid:21882945 + pubmed:22110360 - p(HGNC:BAG2) decreases complex(p(HGNC:STUB1), p(HGNC:UBA2)) + p(HGNC:DYRK1A) increases p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation")) - - - + + + pubmed:22110360 + + p(HGNC:DYRK1A) increases p(HGNC:SNCA, pmod(go:0006468 ! "protein phosphorylation")) + - pmid:25036637 + pubmed:22110360 - p(HGNC:PSMC1) directlyIncreases complex(p(HGNC:PSMC1), p(HGNC:PSMC2)) + p(HGNC:DYRK1A) increases p(HGNC:SNCA, pmod(go:0006468 ! "protein phosphorylation")) - pmid:25036637 + pubmed:22110360 - p(HGNC:PSMC1) directlyIncreases complex(p(HGNC:PSMC1), p(HGNC:PSMD2)) + p(HGNC:DYRK1A) increases p(HGNC:SNCA, pmod(go:0006468 ! "protein phosphorylation")) - - - pmid:25036637 + pubmed:22110360 - p(HGNC:PFDN2) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5)) + p(HGNC:DYRK1A) increases act(p(FPLX:NFAT), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) - pmid:25036637 + pubmed:22110360 - p(HGNC:PFDN2) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5)) + p(HGNC:DYRK1A) increases act(p(FPLX:FOXO), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) - pmid:25036637 + pubmed:22110360 - p(HGNC:PFDN2) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5)) + p(HGNC:DYRK1A) increases act(p(HGNC:DNM1)) - pmid:25036637 + pubmed:22110360 - p(HGNC:PFDN2) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN2)) + p(HGNC:DYRK1A) increases act(p(HGNC:AMPH)) - - - - - - - - - - - - - - - pmid:25036637 + pubmed:22110360 - p(INTERPRO:"BAG domain superfamily") directlyIncreases complex(p(HGNC:HSPA6), p(INTERPRO:"BAG domain superfamily")) + p(HGNC:DYRK1A) association p(HGNC:APP) - pmid:25036637 + pubmed:22110360 - p(INTERPRO:"BAG domain superfamily") directlyIncreases complex(p(HGNC:HSPA8), p(INTERPRO:"BAG domain superfamily")) + p(HGNC:DYRK1A) association path(MESH:"Alzheimer Disease") - - - - - - - - - pmid:25036637 + pubmed:28632203 - p(HGNC:UNC45A) directlyIncreases complex(p(HGNC:HSP90AB1), p(HGNC:UNC45A)) + p(HGNC:DYRK1A) biomarkerFor path(MESH:"Alzheimer Disease") - - - - - - - - - - - - - - - - - - - - - - - - - - - - - pmid:25036637 + pubmed:22110360 - p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:BAG1), p(HGNC:PSMD2)) + p(HGNC:DYRK1A) increases act(p(FPLX:JNK)) - pmid:25036637 + pubmed:22110360 - p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:BAG2), p(HGNC:PSMD2)) + p(HGNC:DYRK1A) increases act(p(HGNC:MAP3K5)) - pmid:25036637 + pubmed:22110360 - p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:BAG3), p(HGNC:PSMD2)) + p(HGNC:DYRK1A) increases bp(GO:"apoptotic process") - pmid:25036637 + pubmed:22110360 - p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:BAG5), p(HGNC:PSMD2)) + act(p(HGNC:DYRK1A)) increases bp(GO:"apoptotic process") - pmid:25036637 + pubmed:22110360 - p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:PSMD2), p(HGNC:STUB1)) + act(p(HGNC:DYRK1A)) association bp(GO:"cell population proliferation") - pmid:25036637 + pubmed:22110360 - p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:PSMD2), p(INTERPRO:"Heat shock protein 70 family")) + act(p(HGNC:DYRK1A)) increases act(p(FPLX:ERK)) - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - + + + pubmed:22110360 + + act(p(HGNC:DYRK1A)) increases complex(p(FPLX:MEK), p(FPLX:RAF), p(FPLX:RAS)) + - + + + pubmed:28137862 + + p(HGNC:DYRK1A) association path(MESH:"Down Syndrome") + - + + + pubmed:28884684 + + act(p(HGNC:DYRK1A), ma(go:0016301 ! "kinase activity")) positiveCorrelation bp(GO:"neuron differentiation") + - + + + pubmed:28250274 + + p(HGNC:DYRK1A) negativeCorrelation p(HGNC:MME) + - + + + pubmed:28167836 + + act(p(HGNC:DYRK1A)) regulates a(CONSO:Neurites) + - + + + pubmed:28167836 + + act(p(HGNC:DYRK1A)) regulates a(GO:axon) + @@ -123701,54 +125631,59 @@

Statements

- + + + pubmed:25116835 + + p(HGNC:DYRK1B) causesNoChange a(NIFT:"Clinical dementia rating") + - + + + pubmed:24961945 + + a(CHEBI:"manganese(2+)") positiveCorrelation a(NIFT:"Mini mental state exam") + - pmid:21882945 + pubmed:24961945 - complex(p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) increases deg(p(HGNC:MAPT)) + a(CHEBI:"manganese(2+)") positiveCorrelation a(NIFT:"Clinical dementia rating") - - - pmid:21882945 + pubmed:19734902 - complex(p(FPLX:HSP90), p(HGNC:STUB1)) association p(HGNC:AKT1) + g(HGNC:PICALM) association g(DBSNP:rs3851179) - pmid:25374103 + pubmed:21379329 - complex(p(FPLX:HSP90), p(HGNC:STUB1)) increases complex(p(FPLX:HSP90), p(HGNC:STUB1), p(MESH:Proteins, pmod(HBP:misfolded))) + g(HGNC:PICALM) association g(DBSNP:rs3851179) - - - - - - - - - + + + pubmed:19734902 + + g(HGNC:PICALM) association g(DBSNP:rs3851179) + @@ -123756,1711 +125691,1750 @@

Statements

- pmid:25036637 + pubmed:19734902 - p(HGNC:VBP1) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5), p(HGNC:VBP1)) + g(HGNC:PICALM) association path(MESH:"Alzheimer Disease") - pmid:25036637 + pubmed:21627779 - p(HGNC:VBP1) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:VBP1)) + g(HGNC:PICALM) association path(MESH:"Alzheimer Disease") - pmid:25036637 + pubmed:21460841 - p(HGNC:VBP1) directlyIncreases complex(p(HGNC:PFDN5), p(HGNC:VBP1)) + g(HGNC:PICALM) association path(MESH:"Alzheimer Disease") - pmid:25036637 + pubmed:21379329 - p(HGNC:UXT) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5), p(HGNC:UXT)) + g(HGNC:PICALM) association path(MESH:"Alzheimer Disease") - pmid:25036637 + pubmed:21627779 - p(HGNC:UXT) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:UXT)) + g(HGNC:PICALM) association g(DBSNP:rs536841) - pmid:25036637 + pubmed:21627779 - p(HGNC:UXT) directlyIncreases complex(p(HGNC:PFDN5), p(HGNC:UXT)) + g(HGNC:PICALM) association g(DBSNP:rs536841) - pmid:25036637 + pubmed:21460841 - p(HGNC:PDRG1) directlyIncreases complex(p(HGNC:PDRG1), p(HGNC:PFDN2), p(HGNC:PFDN5)) + g(HGNC:PICALM) association g(DBSNP:rs5616655) - pmid:25036637 + pubmed:24162737 - p(HGNC:PDRG1) directlyIncreases complex(p(HGNC:PDRG1), p(HGNC:PFDN2)) + g(HGNC:PICALM) association g(DBSNP:rs10792832) - pmid:25036637 + pubmed:22832961 - p(HGNC:PDRG1) directlyIncreases complex(p(HGNC:PDRG1), p(HGNC:PFDN5)) + g(HGNC:PICALM) association g(DBSNP:rs17817600) - pmid:25036637 + pubmed:22005930 - p(HGNC:POLR3A) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5), p(HGNC:POLR3A)) + g(HGNC:PICALM) association g(DBSNP:rs10792830) - pmid:25036637 + pubmed:21460841 - p(HGNC:POLR3A) directlyIncreases complex(p(HGNC:POLR3A), p(HGNC:RPAP3)) + g(HGNC:PICALM) association g(DBSNP:rs561655) - pmid:25036637 + pubmed:" 26517285" - p(HGNC:POLR3A) directlyIncreases complex(p(FPLX:HSP90), p(HGNC:POLR3A)) + g(HGNC:PICALM) association bp(GO:endocytosis) - pmid:25036637 + pubmed:" 26517285" - p(HGNC:URI1) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5), p(HGNC:URI1)) + g(HGNC:PICALM) association bp(GO:"lipid metabolic process") - pmid:25036637 + pubmed:25022885 - p(HGNC:URI1) directlyIncreases complex(p(HGNC:RPAP3), p(HGNC:URI1)) + g(DBSNP:rs3851179) association path(EFO:"late-onset Alzheimers disease") - pmid:25036637 + pubmed:19734902 - p(HGNC:URI1) directlyIncreases complex(p(FPLX:HSP90), p(HGNC:URI1)) + g(DBSNP:rs3851179) association path(MESH:"Alzheimer Disease") - - - - - - - - - - - - - - - + + + pubmed:21379329 + + g(DBSNP:rs3851179) association path(MESH:"Alzheimer Disease") + - + + + pubmed:19734902 + + g(DBSNP:rs3851179) association g(HGNC:PICALM) + - + + + pubmed:21379329 + + g(DBSNP:rs3851179) association g(HGNC:PICALM) + - + + + pubmed:19734902 + + g(DBSNP:rs3851179) association g(HGNC:PICALM) + - + + + pubmed:25022885 + + g(DBSNP:rs541458) association path(EFO:"late-onset Alzheimers disease") + - + + + pubmed:21627779 + + g(HGNC:BIN1) association g(DBSNP:rs744373) + - + + + pubmed:21390209 + + g(HGNC:BIN1) association g(DBSNP:rs744373) + - + + + pubmed:21627779 + + g(HGNC:BIN1) association g(DBSNP:rs744373) + - + + + pubmed:21460840 + + g(HGNC:BIN1) association g(DBSNP:rs744373) + - + + + pubmed:21390209 + + g(HGNC:BIN1) association g(DBSNP:rs744373) + - + + + pubmed:21627779 + + g(HGNC:BIN1) association path(MESH:"Alzheimer Disease") + - + + + pubmed:21460841 + + g(HGNC:BIN1) association path(MESH:"Alzheimer Disease") + - + + + pubmed:21390209 + + g(HGNC:BIN1) association path(MESH:"Alzheimer Disease") + - + + + pubmed:21379329 + + g(HGNC:BIN1) association path(MESH:"Alzheimer Disease") + - + + + pubmed:21460841 + + g(HGNC:BIN1) association g(DBSNP:rs7561528) + - + + + pubmed:21379329 + + g(HGNC:BIN1) association g(DBSNP:rs7561528) + - + + + pubmed:22832961 + + g(HGNC:BIN1) association g(DBSNP:rs7561528) + - pmid:25036637 + pubmed:21460841 - p(INTERPRO:"Leucine-rich repeat domain superfamily") directlyIncreases complex(p(HGNC:SUGT1), p(INTERPRO:"Leucine-rich repeat domain superfamily")) + g(HGNC:BIN1) association g(DBSNP:rs7561528) - + + + pubmed:21390209 + + g(HGNC:BIN1) association g(DBSNP:rs12989701) + - pmid:25036637 + pubmed:21390209 - a(MESH:"Argonaute Proteins") directlyIncreases complex(a(MESH:"Argonaute Proteins"), p(HGNC:PPP5C)) + g(HGNC:BIN1) association g(DBSNP:rs12989701) - pmid:25036637 + pubmed:24162737 - a(MESH:"Argonaute Proteins") directlyIncreases complex(a(MESH:"Argonaute Proteins"), p(HGNC:PTGES3)) + g(HGNC:BIN1) association g(DBSNP:rs6733839) - + + + pubmed:22005930 + + g(HGNC:BIN1) association g(DBSNP:rs10207628) + - pmid:21882945 + pubmed:19734902 - p(HGNC:PPP5C) decreases p(HGNC:MAPT, pmod(Ph)) + g(HGNC:BIN1) association g(DBSNP:rs754107) - pmid:29311797 + pubmed:" 26517285" - act(p(HGNC:PPP5C)) decreases p(HGNC:MAPT, pmod(Ph)) + g(HGNC:BIN1) association bp(GO:endocytosis) - pmid:26631930 + pubmed:25022885 - p(HGNC:PPP5C) directlyDecreases p(HGNC:MAPT, pmod(Ph)) + g(DBSNP:rs744373) association path(EFO:"late-onset Alzheimers disease") - + + + pubmed:21627779 + + g(DBSNP:rs744373) association path(MESH:"Alzheimer Disease") + - pmid:21882945 + pubmed:21390209 - p(HGNC:PTGES3) increases complex(a(MESH:"Protein Kinases"), p(FPLX:HSP90)) + g(DBSNP:rs744373) association path(MESH:"Alzheimer Disease") - pmid:29311797 + pubmed:21627779 - p(HGNC:PTGES3) decreases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) + g(DBSNP:rs744373) association g(HGNC:BIN1) - pmid:29311797 + pubmed:21390209 - p(HGNC:PTGES3) decreases path(MESH:"Protein Aggregation, Pathological") + g(DBSNP:rs744373) association g(HGNC:BIN1) - pmid:29311797 + pubmed:21627779 - p(HGNC:PTGES3) increases p(HGNC:MAPT) + g(DBSNP:rs744373) association g(HGNC:BIN1) - pmid:29311797 + pubmed:21460840 - p(HGNC:PTGES3) increases p(HGNC:MAPT, pmod(Ph)) + g(DBSNP:rs744373) association g(HGNC:BIN1) - pmid:29311797 + pubmed:21390209 - p(HGNC:PTGES3) decreases bp(GO:"cell death in response to oxidative stress") + g(DBSNP:rs744373) association g(HGNC:BIN1) - pmid:25036637 + pubmed:25022885 - p(INTERPRO:"NudC family") association p(INTERPRO:"Heat shock protein Hsp90 family") + path(EFO:"late-onset Alzheimers disease") association g(DBSNP:rs3851179) - pmid:25036637 + pubmed:25022885 - p(HGNC:NUDC) directlyIncreases complex(p(HGNC:NUDC), p(INTERPRO:"WD40-repeat-containing domain superfamily")) + path(EFO:"late-onset Alzheimers disease") association g(DBSNP:rs541458) - pmid:25036637 + pubmed:25022885 - p(HGNC:NUDC) directlyIncreases complex(p(HGNC:NUDC), p(INTERPRO:"WD40-repeat-containing domain")) + path(EFO:"late-onset Alzheimers disease") association g(DBSNP:rs744373) - pmid:25036637 + pubmed:17192785 - p(HGNC:NUDC) directlyIncreases complex(p(HGNC:NUDC), p(INTERPRO:"WD40-repeat-containing domain")) + path(EFO:"late-onset Alzheimers disease") association g(DBSNP:rs4420638) - - - - - pmid:25036637 + pubmed:17192785 - p(HGNC:NUDCD3) directlyIncreases complex(p(HGNC:KLHL13), p(HGNC:NUDCD3)) + path(EFO:"late-onset Alzheimers disease") equivalentTo path(EFO:"late-onset Alzheimers disease") - pmid:25036637 + pubmed:17192785 - p(HGNC:NUDCD3) directlyIncreases complex(p(HGNC:KLHL1), p(HGNC:NUDCD3)) + g(DBSNP:rs4420638) association path(EFO:"late-onset Alzheimers disease") - pmid:25036637 + pubmed:18976728 - p(HGNC:NUDCD3) directlyIncreases complex(p(HGNC:ENC1), p(HGNC:NUDCD3)) + g(DBSNP:rs4420638) association path(MESH:"Alzheimer Disease") - pmid:25036637 + pubmed:17474819 - p(HGNC:NUDCD3) directlyIncreases complex(p(HGNC:NUDCD3), p(INTERPRO:"Kelch-type beta propeller")) + g(DBSNP:rs4420638) association path(MESH:"Alzheimer Disease") - pmid:25036637 + pubmed:17474819 - p(HGNC:NUDCD3) directlyIncreases complex(p(HGNC:NUDCD3), p(INTERPRO:"Kelch-type beta propeller")) + g(DBSNP:rs4420638) association g(HGNC:APOE) - - - - - - - - - - - - - pmid:25036637 + pubmed:23175194 - p(HGNC:NUDCD2) directlyIncreases complex(p(HGNC:FBXO24), p(HGNC:NUDCD2)) + a(NIFT:"Hippocampus volume") negativeCorrelation a(CONSO:"CDR - Sum of Boxes") - pmid:25036637 + pubmed:25778476 - p(HGNC:NUDCD2) directlyIncreases complex(p(HGNC:NUDCD2), p(HGNC:SNX31)) + a(NIFT:"Hippocampus volume") association g(DBSNP:rs2732703) - pmid:25036637 + pubmed:24524964 - p(HGNC:NUDCD2) directlyIncreases complex(p(HGNC:NUDCD2), p(INTERPRO:"Regulator of chromosome condensation, RCC1")) + a(NIFT:"Hippocampus volume") association a(CHEBI:homocysteine) - pmid:25036637 + pubmed:25678559 - p(HGNC:NUDCD2) directlyIncreases complex(p(HGNC:NUDCD2), p(INTERPRO:"Regulator of chromosome condensation, RCC1")) + a(NIFT:"Hippocampus volume") negativeCorrelation p(HGNC:APP) - - - - - - - - - - - - - - - - - - - - - - - - - pmid:25036637 + pubmed:19940480 - p(HGNC:CFAP100) directlyIncreases complex(p(HGNC:ARAF), p(HGNC:CDC37)) + a(NIFT:"Hippocampus volume") negativeCorrelation p(HGNC:APOE, var("p.Cys130Arg")) - - - - - pmid:25036637 + pubmed:22550605 - p(HGNC:NUDCD1) directlyIncreases complex(p(HGNC:NUDCD1), p(INTERPRO:"DEAD/DEAH box helicase domain")) + a(NIFT:"Hippocampus volume") association p(HGNC:TOMM40, var("?")) - pmid:25036637 + pubmed:26043140 - p(HGNC:NUDCD1) directlyIncreases complex(a(GO:"COPI-coated vesicle"), p(HGNC:NUDCD1)) + a(EFO:"cognitive decline measurement") association a(CONSO:"CDR - Sum of Boxes") - - - - - - - - - pmid:25036637 + pubmed:25542982 - a(GO:"COPI-coated vesicle") regulates bp(GO:"retrograde transport, vesicle recycling within Golgi") + a(NIFT:"3-HPMA/Cre ratio") negativeCorrelation a(CONSO:"CDR - Sum of Boxes") - pmid:24706768 + pubmed:25542982 - a(HBP:"polyQ aggregates") decreases act(p(HGNC:DNAJB1)) + a(NIFT:"3-HPMA/Cre ratio") negativeCorrelation a(NIFT:"Mini mental state exam") - pmid:24706768 + pubmed:25542982 - a(HBP:"polyQ aggregates") decreases bp(GO:endocytosis) + a(NIFT:"3-HPMA/Cre ratio") negativeCorrelation a(NIFT:"Abeta_40_42_ratio") - pmid:24706768 + pubmed:25542982 - a(HBP:"Q82 aggregates") decreases bp(GO:"clathrin-dependent endocytosis") + a(NIFT:"3-HPMA/Cre ratio") positiveCorrelation a(InChI:"InChI=1S/C8H15NO4S/c1-6(11)9-7(8(12)13)5-14-4-2-3-10/h7,10H,2-5H2,1H3,(H,9,11)(H,12,13)/t7-/m0/s1") - pmid:24706768 + pubmed:25542982 - p(HGNC:SOD1, var("p.Ala4Val")) decreases bp(GO:"clathrin-dependent endocytosis") + a(NIFT:"3-HPMA/Cre ratio") negativeCorrelation a(CHEBI:creatinine) - - - - - pmid:24706768 + pubmed:25542982 - complex(a(HBP:"protein aggregates"), p(HGNC:HSPA8)) decreases bp(GO:"clathrin-dependent endocytosis") + a(NIFT:"Abeta_40_42_ratio") negativeCorrelation a(NIFT:"3-HPMA/Cre ratio") - pmid:28803412 + pubmed:25542982 - p(HGNC:SNCA, var("p.Glu46Lys")) increases path(MESH:"Parkinson Disease") + a(InChI:"InChI=1S/C8H15NO4S/c1-6(11)9-7(8(12)13)5-14-4-2-3-10/h7,10H,2-5H2,1H3,(H,9,11)(H,12,13)/t7-/m0/s1") positiveCorrelation a(NIFT:"3-HPMA/Cre ratio") - pmid:28803412 + pubmed:25542982 - p(HGNC:SNCA, var("p.His50Gln")) increases path(MESH:"Parkinson Disease") + a(CHEBI:creatinine) negativeCorrelation a(NIFT:"3-HPMA/Cre ratio") - pmid:28803412 + pubmed:24242746 - p(HGNC:SNCA, var("p.Gly51Asp")) increases path(MESH:"Parkinson Disease") + p(HGNC:NEFL) positiveCorrelation a(CONSO:"CDR - Sum of Boxes") - pmid:28803412 + pubmed:26836182 - p(HGNC:SNCA, var("p.Ala53Glu")) increases path(MESH:"Parkinson Disease") + p(HGNC:NEFL) positiveCorrelation p(HGNC:CHI3L1) - pmid:28803412 + pubmed:25429309 - a(HBP:HBP00016) increases path(MESH:"Parkinson Disease") + p(HGNC:SLC6A3) negativeCorrelation a(CONSO:"CDR - Sum of Boxes") - pmid:27075649 + pubmed:30061532 - a(HBP:HBP00016) positiveCorrelation path(MESH:"Parkinson Disease") + p(HGNC:SLC6A3) increases a(CHEBI:dopamine, loc(MESH:"Nerve Endings")) - pmid:27075649 + pubmed:23775979 - a(HBP:HBP00016) positiveCorrelation path(MESH:"Multiple System Atrophy") + complex(a(InChI:"InChI=1S/C22H21NO3/c1-17(24)23(16-18-10-6-8-14-21(18)25-2)20-13-7-9-15-22(20)26-19-11-4-3-5-12-19/h3-15H,16H2,1-2H3/i2-1"), p(HGNC:TSPO)) negativeCorrelation a(CONSO:"CDR - Sum of Boxes") - pmid:27075649 + pubmed:23775979 - a(HBP:HBP00016) positiveCorrelation path(MESH:"Lewy Body Disease") + complex(a(InChI:"InChI=1S/C22H21NO3/c1-17(24)23(16-18-10-6-8-14-21(18)25-2)20-13-7-9-15-22(20)26-19-11-4-3-5-12-19/h3-15H,16H2,1-2H3/i2-1"), p(HGNC:TSPO)) negativeCorrelation a(NIFT:"Mini mental state exam") - pmid:28803412 + pubmed:23775979 - a(HBP:HBP00093) increases path(MESH:"Parkinson Disease") + complex(a(InChI:"InChI=1S/C22H21NO3/c1-17(24)23(16-18-10-6-8-14-21(18)25-2)20-13-7-9-15-22(20)26-19-11-4-3-5-12-19/h3-15H,16H2,1-2H3/i2-1"), p(HGNC:TSPO)) negativeCorrelation a(NIFT:"Logical Memory Immediate") + + + + - pmid:28803412 + pubmed:23775979 - a(HBP:HBP00093) biomarkerFor path(MESH:"Parkinson Disease") + a(NIFT:"Logical Memory Immediate") negativeCorrelation complex(a(InChI:"InChI=1S/C22H21NO3/c1-17(24)23(16-18-10-6-8-14-21(18)25-2)20-13-7-9-15-22(20)26-19-11-4-3-5-12-19/h3-15H,16H2,1-2H3/i2-1"), p(HGNC:TSPO)) - pmid:28803412 + pubmed:25566378 - a(HBP:HBP00093) positiveCorrelation path(MESH:"Parkinson Disease") + path(GO:"short-term memory") positiveCorrelation a(NIFT:"Mini mental state exam") - pmid:28803412 + pubmed:25566378 - a(HBP:HBP00093) increases a(HBP:HBP00092) + path(GO:"short-term memory") negativeCorrelation a(CONSO:"CDR - Sum of Boxes") - pmid:27075649 + pubmed:18346821 - a(HBP:HBP00093) negativeCorrelation a(HBP:HBP00092) + a(MESH:"2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole") positiveCorrelation a(CONSO:"CDR - Sum of Boxes") - pmid:28803412 + pubmed:27768893 - a(HBP:HBP00093) increases bp(GO:"apoptotic process") + p(HGNC:KAT8) association bp(GO:"regulation of oxidative phosphorylation") - pmid:28803412 + pubmed:27768893 - a(HBP:HBP00093) increases bp(GO:"apoptotic process") + p(HGNC:KAT8) regulates complex(GO:"respiratory chain complex") + + - pmid:27075649 + pubmed:21034527 - a(HBP:HBP00093) increases bp(GO:"apoptotic process") + p(HGNC:KAT8) isA p(INTERPRO:"Histone acetyltransferase domain, MYST-type") - pmid:28803412 + pubmed:22544363 - a(HBP:HBP00093) decreases a(MESH:Mitochondria) + p(HGNC:KAT8) association p(HGNC:KANSL1) - pmid:28803412 + pubmed:22544363 - a(HBP:HBP00093) increases bp(HBP:HBP00037) + p(HGNC:KAT8) association p(FPLX:"Histone_H4", pmod(go:0006473 ! "protein acetylation")) - pmid:28803412 + pubmed:27768893 - a(HBP:HBP00093) increases bp(MESH:"Endoplasmic Reticulum Stress") + p(HGNC:KAT8) regulates bp(GO:"oxidative phosphorylation") - pmid:28803412 + pubmed:27768893 - a(HBP:HBP00093) decreases act(complex(GO:"proteasome complex")) + bp(GO:"regulation of oxidative phosphorylation") association p(HGNC:KAT8) - pmid:28803412 + pubmed:24189435 - a(HBP:HBP00093) increases bp(GO:"microglial cell activation") + bp(GO:"regulation of oxidative phosphorylation") increases bp(GO:"mitochondrial electron transport, cytochrome c to oxygen") - pmid:28803412 + pubmed:25778476 - a(HBP:HBP00093) increases bp(GO:"inflammatory response") + p(HGNC:KANSL1) association g(DBSNP:rs113986870) - pmid:28803412 + pubmed:22544363 - a(HBP:HBP00093) increases act(p(HGNC:TLR2)) + p(HGNC:KANSL1) association p(HGNC:KAT8) - pmid:28803412 + pubmed:26293599 - a(HBP:HBP00093) increases a(CHEBI:"reactive oxygen species") + p(HGNC:KANSL1) association p(HGNC:TP53, pmod(go:0006473 ! "protein acetylation")) - pmid:28803412 + pubmed:25778476 - a(HBP:HBP00093) decreases a(MESH:"Cell Membrane") + g(DBSNP:rs113986870) association p(HGNC:KANSL1) - pmid:28803412 + pubmed:25778476 - a(HBP:HBP00093) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(GO:"extracellular space"), toLoc(GO:"intracellular part")) + g(DBSNP:rs113986870) association g(DBSNP:rs2732703) - pmid:27075649 + pubmed:25778476 - a(HBP:HBP00093) increases a(CHEBI:"calcium(2+)") + g(DBSNP:rs2732703) association g(DBSNP:rs113986870) - pmid:28803412 + pubmed:25778476 - a(HBP:HBP00093) decreases bp(GO:"synaptic vesicle transport") + g(DBSNP:rs2732703) association a(NIFT:"Hippocampus volume") + + - pmid:28803412 + pubmed:25478017 - a(HBP:HBP00093) decreases bp(GO:"axonal transport") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 212)) increases complex(a(CONSO:"Tau fibrils"), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 212))) - pmid:28803412 + pubmed:25478017 - a(HBP:HBP00093) decreases complex(a(GO:microtubule), a(MESH:Kinesin)) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 212)) decreases a(CONSO:"Tau fibrils") - pmid:28803412 + pubmed:17078951 - a(HBP:HBP00093) decreases a(MESH:"Golgi Apparatus") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 212)) negativeCorrelation p(FPLX:PKA) - pmid:28803412 + pubmed:22072628 - a(HBP:HBP00092) causesNoChange bp(GO:"apoptotic process") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 212)) partOf p(CONSO:"proline-rich region 2", pmod(go:0006468 ! "protein phosphorylation")) - pmid:27075649 + pubmed:21156028 - a(HBP:HBP00092) increases bp(GO:"apoptotic process") + p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation", Thr, 688)) increases deg(p(HGNC:APP)) + + - pmid:28803412 + pubmed:22110360 - a(HBP:HBP00092) increases bp(GO:"inflammatory response") + act(p(FPLX:NFAT), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases bp(GO:"transcription, DNA-templated") - pmid:28803412 + pubmed:22110360 - a(HBP:HBP00092) increases bp(GO:"microglial cell activation") + p(FPLX:CREB, pmod(go:0006468 ! "protein phosphorylation")) association bp(GO:"neuron differentiation") + + - pmid:27075649 + pubmed:21677163 - a(HBP:HBP00092) increases a(CHEBI:"calcium(2+)") + p(FPLX:CREB) positiveCorrelation bp(GO:"long-term memory") - pmid:27075649 + pubmed:21677163 - a(HBP:HBP00092) negativeCorrelation a(HBP:HBP00093) + p(FPLX:CREB) positiveCorrelation p(HGNC:BDNF) - pmid:27075649 + pubmed:20869593 - a(HBP:HBP00092) increases a(HBP:HBP00016) + p(FPLX:CREB) increases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) - pmid:28803412 + pubmed:19126755 - a(CHEBI:salubrinal) decreases bp(MESH:"Endoplasmic Reticulum Stress") + act(p(FPLX:CREB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) regulates bp(GO:"gene expression") - pmid:28803412 + pubmed:19126755 - a(CHEBI:salubrinal) decreases a(HBP:HBP00093) + act(p(FPLX:CREB)) association bp(MESH:"Neuronal Plasticity") - - - - - pmid:28803412 + pubmed:19126755 - complex(a(HBP:HBP00093), p(HGNC:VAMP1)) decreases bp(GO:"SNARE complex assembly") + act(p(FPLX:CREB)) association path(MESH:"Tobacco Use Disorder") - - - - - pmid:26631930 + pubmed:27550730 - act(a(MESH:Kinesin)) association p(HGNC:MAPT) + act(p(FPLX:CREB)) negativeCorrelation act(p(HGNC:PDE5A)) - pmid:28803412 + pubmed:27550730 - p(HGNC:USP19) increases sec(p(HGNC:SNCA)) + act(p(FPLX:CREB)) negativeCorrelation act(p(FPLX:HDAC)) - pmid:28803412 + pubmed:27550730 - a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases a(HBP:HBP00016) + act(p(FPLX:CREB)) increases p(FPLX:Histone, pmod(go:0006473 ! "protein acetylation")) - pmid:28803412 + pubmed:21722302 - a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases a(HBP:HBP00018) + p(HGNC:SNCA, pmod(go:0006468 ! "protein phosphorylation")) increases p(HGNC:SNCA, pmod(CONSO:misfolded)) - pmid:28803412 + pubmed:30985105 - a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases a(HBP:HBP00017) + p(HGNC:SNCA, pmod(go:0006468 ! "protein phosphorylation")) increases path(MESH:"Parkinson Disease") - pmid:29626319 + pubmed:22110360 - a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases p(HGNC:MAPT, pmod(Ph)) + complex(p(HGNC:DYRK1A), p(HGNC:JKAMP)) increases act(p(HGNC:MAP3K5)) - pmid:29626319 + pubmed:22110360 - a(CHEBI:"(-)-epigallocatechin 3-gallate") increases p(HGNC:CALCOCO2) + complex(p(HGNC:DYRK1A), p(HGNC:JKAMP)) increases bp(GO:"positive regulation of neuron apoptotic process") + + - pmid:29626319 + pubmed:22110360 - a(CHEBI:"(-)-epigallocatechin 3-gallate") increases p(HGNC:SQSTM1) + act(p(HGNC:MAP3K5)) increases bp(GO:"positive regulation of neuron apoptotic process") - pmid:28775333 + pubmed:22110360 - a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases p(MGI:Dyrk1a) + act(p(HGNC:MAP3K5)) increases bp(GO:"apoptotic process") - pmid:28775333 + pubmed:22110360 - a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases p(HBP:"3R tau") + act(p(HGNC:MAP3K5)) increases p(FPLX:p38, pmod(go:0006468 ! "protein phosphorylation")) - pmid:28775333 + pubmed:22110360 - a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases path(MESH:Anxiety) + act(p(HGNC:MAP3K5)) increases p(FPLX:JNK, pmod(go:0006468 ! "protein phosphorylation")) - pmid:28775333 + pubmed:22530628 - a(CHEBI:"(-)-epigallocatechin 3-gallate") positiveCorrelation bp(GO:memory) + p(HGNC:MAP3K5) increases bp(MESH:Apoptosis) - pmid:28803412 + pubmed:21722302 - a(HBP:HBP00094) decreases a(HBP:HBP00016) + p(HGNC:MAP3K5) increases bp(MESH:Apoptosis) + + - pmid:28803412 + pubmed:22530628 - a(HBP:HBP00094) decreases bp(GO:"apoptotic process") + act(p(HGNC:MAP3K5)) decreases bp(MESH:"Cell Survival") - pmid:27075649 + pubmed:30697142 - path(MESH:"Multiple System Atrophy") positiveCorrelation a(HBP:HBP00016) + p(HGNC:MAP3K5) decreases act(p(HGNC:MAPK8)) - pmid:27075649 + pubmed:21722302 - a(HBP:HBP00095) increases bp(GO:"neuron death") + p(HGNC:MAP3K5) increases bp(GO:"JNK cascade") - pmid:27075649 + pubmed:27068745 - a(HBP:HBP00095) decreases bp(GO:"ion homeostasis") + act(p(HGNC:MAP3K5)) positiveCorrelation act(p(HGNC:PRKD1)) - pmid:27075649 + pubmed:27068745 - a(HBP:HBP00095) increases a(HBP:HBP00016) + act(p(HGNC:MAP3K5)) increases act(p(FPLX:JNK)) - pmid:27075649 + pubmed:27068745 - a(CHEBI:glutaraldehyde) increases a(HBP:HBP00093) + act(p(HGNC:MAP3K5)) association p(HGNC:CASP3) - pmid:29807032 + pubmed:22110360 - act(p(NCBIGENE:140621)) association bp(MESH:"Heat-Shock Response") + act(p(FPLX:FOXO), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases bp(GO:"transcription, DNA-templated") - pmid:29807032 + pubmed:" 26517285" - p(NCBIGENE:492507) decreases act(p(NCBIGENE:140621)) + bp(GO:endocytosis) association g(HGNC:BIN1) - pmid:29807032 + pubmed:" 26517285" - path(MESH:"Stress Disorders, Traumatic") increases r(MESH:"corticotropin releasing factor-binding protein") + bp(GO:endocytosis) association g(HGNC:PICALM) - pmid:23211705 + pubmed:" 26517285" - p(MGI:Crh) decreases a(MESH:Estradiol) + bp(GO:endocytosis) association g(HGNC:CD2AP) - pmid:23211705 + pubmed:" 26517285" - p(MGI:Crh) regulates p(HGNC:CGB3) + bp(GO:endocytosis) association g(HGNC:EPHA1) - pmid:23211705 + pubmed:" 26517285" - p(MGI:Crh) decreases p(HGNC:CGB3) + bp(GO:endocytosis) association g(HGNC:SORL1) - pmid:23211705 + pubmed:30027901 - p(MGI:Crh) causesNoChange a(MESH:Progesterone) + bp(GO:endocytosis) association act(p(HGNC:HTT)) - pmid:23211705 + pubmed:29758300 - p(MGI:Crh) decreases a(MESH:Progesterone) + bp(GO:endocytosis) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:23211705 + pubmed:22908190 - p(MGI:Crh) decreases a(MESH:Progesterone) + bp(GO:endocytosis) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:25125464 + pubmed:22908190 - p(MGI:Crh) increases p(MGI:Mapt, pmod(Ph, Ser, 202)) + bp(GO:endocytosis) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:25125464 + pubmed:29758300 - p(MGI:Crh) increases p(MGI:Mapt, pmod(Ph, Thr, 204)) + bp(GO:endocytosis) association p(HGNC:BECN1) - pmid:25125464 + pubmed:22908190 - p(MGI:Crh) increases p(MGI:Mapt, pmod(Ph, Ser, 396)) + bp(GO:endocytosis) increases tloc(a(GO:"intrinsic component of plasma membrane"), fromLoc(GO:"plasma membrane"), toLoc(GO:lysosome)) - pmid:25125464 + pubmed:22908190 - p(MGI:Crh) increases p(MGI:Mapt, pmod(Ph, Ser, 404)) + bp(GO:endocytosis) increases act(a(MESH:Neurons)) - pmid:25125464 + pubmed:22908190 - p(MGI:Crh) increases p(MGI:Mapt, pmod(Ph, Ser, 262)) + bp(GO:endocytosis) association bp(GO:"regulation of synaptic plasticity") - pmid:25125464 + pubmed:22908190 - p(MGI:Crh) increases p(MGI:Mapt, pmod(Ph, Ser, 422)) + bp(GO:endocytosis) increases bp(GO:memory) - pmid:8940412 + pubmed:22908190 - act(p(RGD:Crh)) regulates a(MESH:"Adrenocorticotropic Hormone") + bp(GO:endocytosis) increases bp(GO:learning) - pmid:8940412 + pubmed:22908190 - act(p(RGD:Crh)) increases sec(a(MESH:Glucocorticoids)) + bp(GO:endocytosis) increases bp(MESH:"Synaptic Transmission") - pmid:8940412 + pubmed:22908190 - act(p(RGD:Crh)) positiveCorrelation bp(GO:"inflammatory response") + bp(GO:endocytosis) positiveCorrelation p(HGNC:APP) - pmid:8940412 + pubmed:22908190 - act(p(RGD:Crh)) directlyIncreases act(p(RGD:Crhr1)) + bp(GO:endocytosis) positiveCorrelation g(CONSO:"APOE e4") - pmid:8940412 + pubmed:22908190 - a(CHEBI:antalarmin) directlyDecreases act(p(RGD:Crh)) + bp(GO:endocytosis) positiveCorrelation a(CHEBI:cholesterol) - pmid:8940412 + pubmed:22908190 - a(CHEBI:antalarmin) decreases sec(p(RGD:Crh)) + bp(GO:endocytosis) positiveCorrelation a(MESH:Proteins) - pmid:8940412 + pubmed:22908190 - a(CHEBI:antalarmin) directlyDecreases act(p(RGD:Crhr1)) + bp(GO:endocytosis) positiveCorrelation a(CHEBI:lipid) - pmid:8940412 + pubmed:22908190 - a(CHEBI:antalarmin) negativeCorrelation bp(GO:"inflammatory response") + bp(GO:endocytosis) negativeCorrelation bp(GO:"lysosomal protein catabolic process") - pmid:8940412 + pubmed:22908190 - act(p(RGD:Crhr2)) decreases act(p(RGD:Crhr1)) + bp(GO:endocytosis) positiveCorrelation a(CHEBI:amyloid-beta) - pmid:30145931 + pubmed:22908190 - a(CHEBI:"bafilomycin A1") decreases bp(GO:autophagy) + bp(GO:endocytosis) positiveCorrelation a(CHEBI:amyloid-beta) - pmid:26702100 + pubmed:22908190 - a(CHEBI:"bafilomycin A1") decreases act(complex(GO:"vacuolar proton-transporting V-type ATPase complex")) + bp(GO:endocytosis) positiveCorrelation act(a(GO:synapse)) - pmid:26702100 + pubmed:22908190 - a(CHEBI:"bafilomycin A1") increases p(HGNC:MAP1LC3B) + bp(GO:endocytosis) positiveCorrelation p(CONSO:"APP C-terminally truncated carboxyl-terminal fragments") - pmid:26702100 + pubmed:22908190 - a(CHEBI:"bafilomycin A1") increases a(GO:autolysosome) + bp(GO:endocytosis) positiveCorrelation tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:cytosol), toLoc(GO:lysosome)) - pmid:30145931 + pubmed:18930136 - a(CHEBI:epoxomicin) decreases act(p(FPLX:Proteasome)) + bp(GO:endocytosis) increases a(GO:lysosome) - pmid:23528736 + pubmed:29590627 - a(CHEBI:epoxomicin) decreases act(p(FPLX:Proteasome)) + bp(GO:endocytosis) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) - pmid:30145931 + pubmed:29590627 - a(CHEBI:epoxomicin) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356)) + bp(GO:endocytosis) increases tloc(a(CONSO:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) - pmid:30145931 + pubmed:29590627 - a(CHEBI:epoxomicin) causesNoChange p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) + bp(GO:endocytosis) increases tloc(a(CONSO:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) - pmid:24027553 + pubmed:28420982 - a(CHEBI:epoxomicin) increases act(p(HGNC:CASP3)) + bp(GO:endocytosis) increases tloc(a(CONSO:"Tau aggregates"), fromLoc(GO:endosome), toLoc(GO:lysosome)) - pmid:24027553 + pubmed:29686391 - a(CHEBI:epoxomicin) decreases deg(p(HGNC:MAPT)) + bp(GO:endocytosis) positiveCorrelation bp(GO:"mitotic G1 phase") - pmid:24027553 + pubmed:22110360 - a(CHEBI:epoxomicin) increases p(HGNC:MAPT) + act(p(HGNC:AMPH)) increases bp(GO:endocytosis) - pmid:23528736 + pubmed:22110360 - a(CHEBI:epoxomicin) decreases deg(p(HGNC:MAPT)) + act(p(HGNC:AMPH)) increases bp(GO:"synaptic vesicle budding from endosome") - - - - - pmid:30145931 + pubmed:22110360 - composite(a(CHEBI:epoxomicin), p(HGNC:MAPT)) increases bp(GO:"protein ubiquitination") + bp(GO:"response to endoplasmic reticulum stress") increases act(p(HGNC:MAP3K5)) - pmid:30145931 + pubmed:27299292 - composite(a(CHEBI:epoxomicin), p(HGNC:MAPT)) decreases a(MESH:"Dendritic Spines") + bp(GO:"response to endoplasmic reticulum stress") increases tloc(p(HGNC:TFE3), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) - pmid:30145931 + pubmed:27299292 - p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356)) positiveCorrelation a(HBP:"amyloid-beta oligomers") + bp(GO:"response to endoplasmic reticulum stress") increases tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) - pmid:30145931 + pubmed:27299292 - p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356)) positiveCorrelation a(CHEBI:wortmannin) + bp(GO:"response to endoplasmic reticulum stress") increases act(p(HGNC:TFEB)) - pmid:30145931 + pubmed:27299292 - p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356)) positiveCorrelation a(CHEBI:epoxomicin) + bp(GO:"response to endoplasmic reticulum stress") association p(HGNC:EIF2AK3) - pmid:26631930 + pubmed:27299292 - p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356)) decreases complex(p(HGNC:MAPT), p(HGNC:STUB1)) + bp(GO:"response to endoplasmic reticulum stress") association act(p(HGNC:PPP3CA), ma(go:0016791 ! "phosphatase activity")) - pmid:26631930 + pubmed:24563850 - p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356)) decreases deg(p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356))) + bp(GO:"response to endoplasmic reticulum stress") increases act(p(HGNC:HSPA5)) - pmid:30145931 + pubmed:24563850 - a(CHEBI:rolipram) increases act(p(FPLX:Proteasome)) + bp(GO:"response to endoplasmic reticulum stress") decreases bp(CONSO:misfolding) - pmid:30145931 + pubmed:24563850 - a(CHEBI:rolipram) decreases p(HGNC:MAPT, loc(MESH:Dendrites)) + bp(GO:"response to endoplasmic reticulum stress") decreases bp(GO:"cell death") - pmid:29626319 + pubmed:24563850 - a(CHEBI:rolipram) increases deg(p(HGNC:MAPT)) + bp(GO:"response to endoplasmic reticulum stress") increases bp(GO:"cell death") - pmid:29626319 + pubmed:24563850 - a(CHEBI:rolipram) increases a(CHEBI:"3',5'-cyclic AMP") + bp(GO:"response to endoplasmic reticulum stress") increases bp(GO:"apoptotic process") - pmid:26692334 + pubmed:26142647 - a(CHEBI:rolipram) increases a(CHEBI:"3',5'-cyclic AMP") + bp(GO:"response to endoplasmic reticulum stress") increases p(HGNC:PPP1R15A) - pmid:26692334 + pubmed:23702978 - a(CHEBI:rolipram) directlyDecreases act(p(FPLX:PDE4)) + bp(GO:"response to endoplasmic reticulum stress") increases act(complex(GO:"NLRP3 inflammasome complex")) - pmid:26692334 + pubmed:22110360 - a(CHEBI:rolipram) increases act(p(FPLX:PKA)) + p(FPLX:p38, pmod(go:0006468 ! "protein phosphorylation")) increases act(p(FPLX:p38)) - pmid:26692334 + pubmed:29121589 - a(CHEBI:rolipram) increases act(complex(GO:"proteasome complex")) + p(FPLX:p38, pmod(go:0006468 ! "protein phosphorylation")) increases act(p(FPLX:p38)) - pmid:26692334 + pubmed:11880483 - a(CHEBI:rolipram) decreases a(HBP:"Tau aggregates") + p(FPLX:p38, pmod(go:0006468 ! "protein phosphorylation")) association p(HGNC:BDNF) - pmid:26692334 + pubmed:11880483 - a(CHEBI:rolipram) increases p(HGNC:MAPT, pmod(Ph, Ser, 214)) + p(FPLX:p38, pmod(go:0006468 ! "protein phosphorylation")) association bp(GO:"regulation of synaptic plasticity") - - - pmid:30145931 + pubmed:22110360 - composite(a(CHEBI:wortmannin), p(HGNC:MAPT)) decreases a(MESH:"Dendritic Spines") + p(HGNC:DAXX) increases act(p(HGNC:MAP3K5)) - pmid:30145931 + pubmed:22110360 - a(CHEBI:cycloheximide) decreases bp(GO:translation) + p(FPLX:TXN) directlyDecreases act(p(HGNC:MAP3K5)) - pmid:30145931 + pubmed:22110360 - a(CHEBI:cycloheximide) decreases p(HGNC:MAPT, loc(MESH:Dendrites)) + p(FPLX:"p14_3_3") directlyDecreases act(p(HGNC:MAP3K5)) - pmid:23702978 + pubmed:22040696 - a(CHEBI:cycloheximide) increases bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") + p(FPLX:"p14_3_3") increases p(FPLX:CHRN) - pmid:30145931 + pubmed:31248781 - a(CHEBI:"(-)-anisomycin") decreases bp(GO:translation) + bp(GO:"stress-activated protein kinase signaling cascade") negativeCorrelation bp(MESH:Neuroprotection) - pmid:30145931 + pubmed:22110360 - a(CHEBI:"(-)-anisomycin") decreases p(HGNC:MAPT, loc(MESH:Dendrites)) + complex(p(FPLX:MEK), p(FPLX:RAF), p(FPLX:RAS)) increases act(p(FPLX:ERK)) + + + + + + + + + + - pmid:22072628 + pubmed:19293145 - p(HGNC:MAPT, pmod(Ph, Ser, 235)) partOf p(HBP:"proline-rich region 2", pmod(Ph)) + act(p(FPLX:RAS)) increases p(HGNC:STAT3) - pmid:26996941 + pubmed:18986241 - p(HGNC:MAPT, pmod(Ph, Ser, 235)) association act(p(HGNC:PIN1)) + p(FPLX:RAS) association bp(GO:"phosphatidylinositol 3-kinase signaling") - - - - - - - - - + + + pubmed:18986241 + + p(FPLX:RAS) association bp(GO:"protein kinase B signaling") + @@ -125472,9 +127446,9 @@

Statements

- pmid:8282104 + pubmed:21034527 - a(HBP:HBP00172) directlyIncreases p(HBP:HBP00053, pmod(Ph)) + p(INTERPRO:"Amyloidogenic glycoprotein, intracellular domain, conserved site") association act(p(HGNC:APP), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) @@ -125485,292 +127459,313 @@

Statements

- pmid:8282104 + pubmed:21034527 - complex(a(HBP:HBP00172), p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(Ph)) + complex(p(HGNC:APBB1), p(HGNC:KAT8), p(INTERPRO:"Amyloidogenic glycoprotein, intracellular domain, conserved site")) increases act(p(HGNC:LGALS4)) - pmid:8282104 + pubmed:21034527 - a(HBP:HBP00006) association p(HGNC:CDK5) + complex(p(HGNC:APBB1), p(HGNC:TFCP2), p(INTERPRO:"Amyloidogenic glycoprotein, intracellular domain, conserved site")) increases act(p(HGNC:GSK3B)) - pmid:8282104 + pubmed:21034527 - a(HBP:HBP00006) association p(HGNC:PRKACA) + act(p(HGNC:SP1), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) association p(HGNC:APBB1) + + - pmid:8282104 + pubmed:23092889 - a(HBP:HBP00006) association p(FPLX:ERK) + p(HGNC:EIF2AK2) increases bp(GO:"inflammatory response") - pmid:8282104 + pubmed:23092889 - a(HBP:HBP00006) association p(FPLX:GSK3) + p(HGNC:EIF2AK2) association p(HGNC:MAPK1) - + + + pubmed:23092889 + + p(HGNC:EIF2AK2) increases p(HGNC:IRF3) + - pmid:27594586 + pubmed:23092889 - g(DBSNP:rs63751011) increases p(HGNC:MAP2) + p(HGNC:EIF2AK2) increases p(HGNC:NFKB1) - pmid:27594586 + pubmed:23092889 - g(DBSNP:rs63751011) causesNoChange a(GO:"symmetric, GABA-ergic, inhibitory synapse") + p(HGNC:EIF2AK2) regulates bp(GO:"neuron apoptotic process") - pmid:27594586 + pubmed:23092889 - g(DBSNP:rs63751011) causesNoChange p(HGNC:SLC17A7) + p(HGNC:EIF2AK2) increases bp(GO:autophagy) - pmid:27594586 + pubmed:23092889 - g(DBSNP:rs63751011) causesNoChange p(HGNC:MAPT) + p(HGNC:EIF2AK2) increases act(complex(GO:"inflammasome complex")) - pmid:27594586 + pubmed:23092889 - g(DBSNP:rs63751011) causesNoChange p(HGNC:DLGAP4) + p(HGNC:EIF2AK2) increases act(complex(GO:"inflammasome complex")) + + + + - pmid:27594586 + pubmed:23092889 - g(DBSNP:rs63751011) causesNoChange bp(MESH:"Membrane Potentials") + act(p(HGNC:EIF2AK2)) increases complex(p(HGNC:EIF2AK2), p(HGNC:NLRP1)) + + - pmid:27594586 + pubmed:23092889 - g(DBSNP:rs63751011) causesNoChange bp(GO:"neuron differentiation") + act(p(HGNC:EIF2AK2)) increases complex(p(HGNC:EIF2AK2), p(HGNC:NLRP3)) + + - pmid:27594586 + pubmed:23092889 - g(DBSNP:rs63751011) increases act(p(HGNC:MMP9)) + act(p(HGNC:EIF2AK2)) increases complex(p(HGNC:EIF2AK2), p(HGNC:NLRC4)) + + - pmid:27594586 + pubmed:23092889 - g(DBSNP:rs63751011) increases sec(p(HGNC:MMP9)) + act(p(HGNC:EIF2AK2)) increases complex(p(HGNC:AIM2), p(HGNC:EIF2AK2)) - pmid:27594586 + pubmed:24173717 - g(DBSNP:rs63751011) increases r(HGNC:MMP9) + bp(GO:pyroptosis) negativeCorrelation p(HGNC:TUBB6) - pmid:27594586 + pubmed:23092889 - g(DBSNP:rs63751011) increases r(HGNC:MMP9) + p(HGNC:YME1L1) increases p(HGNC:EIF2AK2, pmod(go:0006468 ! "protein phosphorylation")) - pmid:27594586 + pubmed:23092889 - g(DBSNP:rs63751011) increases r(HGNC:MMP2) + p(HGNC:EIF2AK2, pmod(go:0006468 ! "protein phosphorylation")) increases act(p(HGNC:EIF2AK2)) - pmid:27594586 + pubmed:23092889 - g(DBSNP:rs63751011) increases r(HGNC:MMP2) + complex(p(HGNC:EIF2AK2), p(HGNC:NLRP1)) increases act(complex(GO:"inflammasome complex")) - pmid:27594586 + pubmed:23092889 - g(DBSNP:rs63751011) increases bp(GO:"neuron death") + complex(p(HGNC:EIF2AK2), p(HGNC:NLRP3)) increases act(complex(GO:"inflammasome complex")) - pmid:27594586 + pubmed:23092889 - g(DBSNP:rs63751011) increases a(HBP:HBP00045) + complex(p(HGNC:EIF2AK2), p(HGNC:NLRC4)) increases act(complex(GO:"inflammasome complex")) - pmid:27594586 + pubmed:23092889 - g(DBSNP:rs63751011) decreases a(HBP:HBP00044) + complex(p(HGNC:AIM2), p(HGNC:EIF2AK2)) increases act(complex(GO:"inflammasome complex")) - pmid:27594586 + pubmed:22544363 - path(MESH:"Neurodevelopmental Disorders") association act(p(HGNC:MMP9)) + p(FPLX:"Histone_H4", pmod(go:0006473 ! "protein acetylation")) association p(HGNC:KAT8) - pmid:27594586 + pubmed:22544363 - a(CHEBI:staurosporine) increases bp(GO:"apoptotic process") + p(FPLX:"Histone_H4", pmod(go:0006473 ! "protein acetylation")) association bp(GO:"regulation of gene expression, epigenetic") + + - pmid:8726973 + pubmed:22544363 - a(CHEBI:staurosporine) decreases act(p(HGNC:CDK5)) + bp(GO:"regulation of gene expression, epigenetic") association p(FPLX:"Histone_H4", pmod(go:0006473 ! "protein acetylation")) - pmid:23666762 + pubmed:30988501 - a(CHEBI:staurosporine) decreases complex(p(HGNC:MAPT), p(HGNC:MARK1)) + bp(GO:"regulation of gene expression, epigenetic") regulates bp(MESH:"Immunity, Innate") - pmid:23666762 + pubmed:11880483 - a(CHEBI:staurosporine) decreases complex(p(HGNC:MAPT), p(HGNC:MARK2)) + p(HGNCGENEFAMILY:"Mitogen-activated protein kinases", pmod(go:0006468 ! "protein phosphorylation")) association p(HGNC:BDNF) - pmid:23001711 + pubmed:11880483 - a(CHEBI:staurosporine) decreases complex(p(HGNC:MAPT), p(HGNC:MARK2)) + p(HGNCGENEFAMILY:"Mitogen-activated protein kinases", pmod(go:0006468 ! "protein phosphorylation")) association bp(GO:"regulation of synaptic plasticity") - pmid:23666762 + pubmed:18986241 - a(CHEBI:staurosporine) decreases complex(p(HGNC:MAPT), p(HGNC:MARK3)) + p(HGNCGENEFAMILY:"Mitogen-activated protein kinases", pmod(go:0006468 ! "protein phosphorylation")) increases act(p(HGNCGENEFAMILY:"Mitogen-activated protein kinases")) + + - pmid:23666762 + pubmed:18986241 - a(CHEBI:staurosporine) decreases complex(p(HGNC:MAPT), p(HGNC:MARK4)) + act(p(HGNCGENEFAMILY:"Mitogen-activated protein kinases")) association bp(GO:"neuron projection development") - pmid:23001711 + pubmed:21861815 - a(CHEBI:staurosporine) decreases act(p(HGNC:MARK2), ma(kin)) + p(HGNCGENEFAMILY:"Mitogen-activated protein kinases") increases p(HGNC:HIF1A, pmod(go:0006468 ! "protein phosphorylation", Thr, 796)) - pmid:23001711 + pubmed:21861815 - a(CHEBI:staurosporine) decreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + p(HGNCGENEFAMILY:"Mitogen-activated protein kinases") increases act(p(MESH:"Hypoxia-Inducible Factor 1")) - pmid:27594586 + pubmed:26136662 - a(CHEBI:rotenone) increases bp(HBP:HBP00037) + p(FPLX:Histone, pmod(go:0006473 ! "protein acetylation", Lys, 280)) association path(MESH:"Alzheimer Disease") @@ -125781,7832 +127776,7702 @@

Statements

- pmid:27594586 + pubmed:27041503 - composite(a(CHEBI:rotenone), p(HGNC:MAPT, var("p.Ala152Thr"))) causesNoChange bp(GO:"neuron death") + p(HGNC:WWC1) decreases p(HGNC:GRIA1) - - - - - pmid:27594586 + pubmed:27041503 - composite(a(CHEBI:staurosporine), p(HGNC:MAPT, var("p.Ala152Thr"))) causesNoChange bp(GO:"neuron death") + p(HGNC:WWC1) decreases bp(GO:"actin polymerization or depolymerization") - pmid:27594586 + pubmed:25800888 - a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") decreases p(FPLX:ERK, pmod(Ph)) + p(HGNC:WWC1) association bp(GO:"regulation of synaptic plasticity") - pmid:27594586 + pubmed:25800888 - a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") decreases sec(p(HGNC:MMP9)) + p(HGNC:WWC1) association g(DBSNP:rs17070145) - pmid:27594586 + pubmed:27041503 - a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") decreases act(p(HGNC:MMP9)) + p(HGNC:WWC1) association bp(GO:memory) - pmid:27594586 + pubmed:27041503 - a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") causesNoChange act(p(HGNC:MMP2)) + p(HGNC:WWC1) negativeCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) - pmid:27594586 + pubmed:27041503 - a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") causesNoChange p(HGNC:MMP2) + bp(GO:"actin polymerization or depolymerization") increases bp(GO:"long-term synaptic depression") - pmid:27594586 + pubmed:25570489 - p(HBP:HBP00045, var("p.Ala152Thr")) increases sec(p(HGNC:MMP9)) + a(NIFT:"Hippocampal atrophy") association p(HGNC:ESR1) - pmid:27594586 + pubmed:20100581 - p(HBP:HBP00045, var("p.Ala152Thr")) increases act(p(HGNC:MMP9)) + a(NIFT:"Hippocampal atrophy") association bp(GO:"apoptotic process") - pmid:27594586 + pubmed:20065247 - p(HBP:HBP00045, var("p.Ala152Thr")) increases sec(p(HGNC:MMP9)) + a(NIFT:"Hippocampal atrophy") positiveCorrelation p(HGNC:APP) - pmid:27594586 + pubmed:24028866 - p(HBP:HBP00045, var("p.Ala152Thr")) increases act(p(HGNC:MMP9)) + a(NIFT:"Hippocampal atrophy") positiveCorrelation a(CHEBI:homocysteine) - pmid:27594586 + pubmed:21871088 - p(HBP:HBP00045, var("p.Ala152Thr")) increases r(HGNC:MMP9) + a(NIFT:"Hippocampal atrophy") association bp(GO:"microglial cell activation") - pmid:27594586 + pubmed:20869593 - p(HBP:HBP00045, var("p.Ala152Thr")) increases p(FPLX:ERK, pmod(Ph)) + path(MESH:"Frontotemporal Dementia") association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:27594586 + pubmed:30061532 - p(HBP:HBP00045, var("p.Ala152Thr")) increases bp(GO:"ERK1 and ERK2 cascade") + path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:27594586 + pubmed:12428809 - p(HBP:HBP00045, var("p.Ala152Thr")) increases sec(p(HGNC:MMP2)) + path(MESH:"Frontotemporal Dementia") positiveCorrelation p(CONSO:"4R tau") - pmid:27594586 + pubmed:26751493 - p(HBP:HBP00045, var("p.Ala152Thr")) increases act(p(HGNC:MMP2)) + path(MESH:"Frontotemporal Dementia") positiveCorrelation p(CONSO:"4R tau") - - - pmid:27594586 + pubmed:22299660 - p(HBP:HBP00044, var("p.Ala152Thr")) causesNoChange sec(p(HGNC:MMP9)) + path(MESH:"Frontotemporal Dementia") association p(FPLX:PPP2) - pmid:27594586 + pubmed:22299660 - p(HBP:HBP00044, var("p.Ala152Thr")) causesNoChange act(p(HGNC:MMP9)) + path(MESH:"Frontotemporal Dementia") association p(HGNC:MAPT, var("?")) - pmid:27594586 + pubmed:29758300 - p(HBP:HBP00044, var("p.Ala152Thr")) causesNoChange p(FPLX:ERK, pmod(Ph)) + path(MESH:"Frontotemporal Dementia") association p(HGNC:MAPT) - - - + + + pubmed:28420982 + + path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT) + - pmid:30116051 + pubmed:29758300 - composite(a(CHEBI:"NAD(+)"), p(HGNC:SIRT1)) increases bp(GO:macroautophagy) + path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:TARDBP, pmod(CONSO:misfolding)) - pmid:30116051 + pubmed:30116051 - p(HGNC:ULK1, pmod(Ph, Ser, 317)) increases act(p(HGNC:ULK1)) + path(MESH:"Frontotemporal Dementia") association p(HGNC:SQSTM1) - pmid:30116051 + pubmed:30116051 - p(HGNC:ULK1, pmod(Ph, Ser, 777)) increases act(p(HGNC:ULK1)) + path(MESH:"Frontotemporal Dementia") association p(HGNC:C9orf72) - pmid:30116051 + pubmed:30116051 - p(FPLX:mTORC1, pmod(Ph)) decreases act(p(FPLX:mTORC1)) + path(MESH:"Frontotemporal Dementia") association path(MESH:"Amyotrophic Lateral Sclerosis") - pmid:30116051 + pubmed:30116051 - p(HGNC:ULK1, pmod(Ph, Ser, 757)) decreases act(p(HGNC:ULK1)) + path(MESH:"Frontotemporal Dementia") increases act(p(HGNC:ABL1)) - pmid:30116051 + pubmed:29024336 - p(HGNC:FOXO1) increases bp(GO:macroautophagy) + path(MESH:"Frontotemporal Dementia") increases path(MESH:"Proteostasis Deficiencies") - pmid:30116051 + pubmed:24027553 - p(HGNC:FOXO3) increases bp(GO:macroautophagy) + path(MESH:"Frontotemporal Dementia") association p(HGNC:MAPT, var("p.Pro301Leu")) - pmid:30116051 + pubmed:26751493 - p(HGNC:ZKSCAN3) decreases bp(GO:macroautophagy) + path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) - pmid:30116051 + pubmed:23294633 - p(HGNC:AMBRA1, pmod(Ph)) increases act(p(HGNC:AMBRA1)) + path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) - - - pmid:30116051 + pubmed:24027553 - act(p(HGNC:AMBRA1)) increases bp(GO:"autophagosome assembly") + path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:NPEPPS) - pmid:30116051 + pubmed:30108137 - p(HGNC:LGMN) increases p(HGNC:MAPT, frag("?")) + path(MESH:"Frontotemporal Dementia") increases r(HGNC:TFEB) - pmid:30116051 + pubmed:30108137 - act(complex(GO:"lysosomal proton-transporting V-type ATPase complex")) negativeCorrelation g(HGNC:PSEN1, var("?")) + path(MESH:"Frontotemporal Dementia") increases r(HGNC:LAMP1) - pmid:30116051 + pubmed:30108137 - p(HGNC:GBA, var("?")) increases path(MESH:"Gaucher Disease") + path(MESH:"Frontotemporal Dementia") increases p(HGNC:TFEB) - pmid:30116051 + pubmed:30108137 - p(HGNC:GBA, var("?")) decreases bp(GO:macroautophagy) + path(MESH:"Frontotemporal Dementia") increases p(HGNC:LAMP1) - pmid:30116051 + pubmed:30108137 - p(HGNC:GBA, var("?")) increases p(HGNC:SNCA) + path(MESH:"Frontotemporal Dementia") increases p(HGNC:CTSD) - pmid:30116051 + pubmed:28420982 - p(HGNC:GBA, var("?")) increases path(MESH:"Parkinson Disease") + path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) - - - pmid:30116051 + pubmed:28420982 - p(HGNC:C9orf72) association path(MESH:"Frontotemporal Dementia") + path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 181)) - - - pmid:30116051 + pubmed:26751493 - p(HGNC:CHMP2B) association path(MESH:"Amyotrophic Lateral Sclerosis") + path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, var("p.Val337Met")) - pmid:30116051 + pubmed:26751493 - p(HGNC:TBK1) association path(MESH:"Amyotrophic Lateral Sclerosis") + path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, var("p.Gly272Val")) - pmid:27181519 + pubmed:26751493 - p(HGNC:TBK1) association path(MESH:"Amyotrophic Lateral Sclerosis") + path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, var("p.Arg406Trp")) - pmid:27181519 + pubmed:26751493 - p(HGNC:TBK1) increases path(MESH:"Amyotrophic Lateral Sclerosis") + path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:PSEN1, var("p.Gly183Val")) - - - pmid:27181519 + pubmed:26631930 - p(HGNC:TBK1) association path(MESH:"Liver Diseases") + path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) - pmid:27181519 + pubmed:29980653 - p(HGNC:TBK1) association path(HBP:Neurodegeneration) + path(MESH:"Frontotemporal Dementia") isA path(MESH:"Neurodegenerative Diseases") - pmid:27181519 + pubmed:29980653 - p(HGNC:TBK1) increases p(HGNC:OPTN, pmod(Ph)) + path(MESH:"Frontotemporal Dementia") positiveCorrelation p(HGNC:TARDBP, var("?")) - pmid:30116051 + pubmed:8391280 - p(HGNC:OPTN) association path(MESH:"Amyotrophic Lateral Sclerosis") + path(MESH:"Frontotemporal Dementia") positiveCorrelation g(DBSNP:rs63750424) - pmid:27181519 + pubmed:26293599 - p(HGNC:OPTN) association path(MESH:"Amyotrophic Lateral Sclerosis") + p(HGNC:TP53, pmod(go:0006473 ! "protein acetylation")) association p(HGNC:KANSL1) - - - pmid:27181519 + pubmed:26293599 - p(HGNC:OPTN) increases bp(GO:autophagy) + p(HGNC:BTG2) association p(HGNC:TP53) - pmid:27181519 + pubmed:26293599 - p(HGNC:OPTN) increases deg(p(HGNC:HTT)) + p(HGNC:BTG2) increases bp(GO:"activation of MAPKK activity") - + + + pubmed:15601849 + + bp(GO:"activation of MAPKK activity") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + - + + + pubmed:30515821 + + bp(GO:"oxidative phosphorylation") increases a(CHEBI:ATP) + - pmid:30116051 + pubmed:30515821 - p(HGNC:OPTN, var("?")) decreases bp(GO:"cargo loading into vesicle") + bp(GO:"oxidative phosphorylation") positiveCorrelation p(HGNC:DNM1) - pmid:27181519 + pubmed:30027901 - p(HGNC:OPTN, var("?")) association path(MESH:"Amyotrophic Lateral Sclerosis") + bp(GO:"oxidative phosphorylation") association path(MESH:"Huntington Disease") - pmid:30116051 + pubmed:30126037 - p(HGNC:TBK1, var("?")) decreases bp(GO:"cargo loading into vesicle") + bp(GO:"oxidative phosphorylation") decreases bp(GO:"oxygen transport") - pmid:30116051 + pubmed:24189435 - p(HGNC:C9orf72, var("?")) decreases bp(GO:autophagy) + bp(GO:"mitochondrial electron transport, cytochrome c to oxygen") association bp(GO:"response to oxidative stress") - pmid:30116051 + pubmed:22710270 - a(CHEBI:clonidine) increases bp(GO:autophagy) + p(HGNC:PSEN1, var("p.Glu280Ala")) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:30116051 + pubmed:22710270 - a(CHEBI:clonidine) increases deg(p(HGNC:HTT)) + g(HGNC:CD44) association path(MESH:"Alzheimer Disease") - pmid:30116051 + pubmed:22710270 - a(CHEBI:Rilmenidine) increases bp(GO:autophagy) + g(HGNC:CD44) association g(DBSNP:rs187116) - pmid:30116051 + pubmed:22710270 - a(CHEBI:Rilmenidine) increases deg(p(HGNC:HTT)) + g(DBSNP:rs187116) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:30116051 + pubmed:22710270 - p(HGNC:CAPN2) decreases bp(GO:autophagy) + g(DBSNP:rs187116) association g(HGNC:CD44) - pmid:30116051 + pubmed:22710270 - p(HGNC:CAPN2) decreases deg(p(HGNC:HTT, var("?"))) + g(HGNC:NPHP1) association path(MESH:"Alzheimer Disease") - pmid:24027553 + pubmed:22710270 - p(HGNC:CAPN2) association path(MESH:"Neurofibrillary Tangles") + g(HGNC:NPHP1) association g(DBSNP:rs10173717) - pmid:30116051 + pubmed:22710270 - p(HGNC:CAST) decreases act(p(HGNC:CAPN1)) + g(DBSNP:rs10173717) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:30116051 + pubmed:22710270 - p(HGNC:CAST) decreases act(p(HGNC:CAPN2)) + g(DBSNP:rs10173717) association g(HGNC:NPHP1) - pmid:30116051 + pubmed:22710270 - p(HGNC:CAST) increases bp(GO:autophagy) + g(HGNC:CADPS2) association path(MESH:"Alzheimer Disease") - pmid:30116051 + pubmed:22710270 - p(HGNC:CAST) increases deg(p(HGNC:HTT, var("?"))) + g(HGNC:CADPS2) association g(DBSNP:rs3757536) - pmid:30116051 + pubmed:22710270 - p(HGNC:CAST) increases deg(p(HGNC:MAPT)) + g(DBSNP:rs3757536) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:30116051 + pubmed:22710270 - p(HGNC:CAST) increases deg(p(HGNC:SNCA)) + g(DBSNP:rs3757536) association g(HGNC:CADPS2) - pmid:30116051 + pubmed:22710270 - p(HGNC:CAST) increases deg(p(HGNC:SOD1)) + g(HGNC:GREM2) association path(MESH:"Alzheimer Disease") - pmid:30116051 + pubmed:22710270 - a(CHEBI:Calpeptin) decreases act(p(HGNC:CAPN1)) + g(HGNC:GREM2) association g(DBSNP:rs12129547) - pmid:30116051 + pubmed:22710270 - a(CHEBI:Calpeptin) decreases act(p(HGNC:CAPN2)) + g(DBSNP:rs12129547) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:30116051 + pubmed:22710270 - a(CHEBI:Calpeptin) increases bp(GO:autophagy) + g(DBSNP:rs12129547) association g(HGNC:GREM2) - pmid:30116051 + pubmed:21769591 - a(CHEBI:Calpeptin) increases deg(p(HGNC:HTT, var("?"))) + g(DBSNP:rs11542041) transcribedTo r(DBSNP:rs11542041) - pmid:30116051 + pubmed:21769591 - a(CHEBI:"AICA ribonucleotide") increases act(p(FPLX:AMPK)) + r(DBSNP:rs11542041) translatedTo p(HGNC:APOE, var("p.Arg132Ser")) - pmid:22419736 + pubmed:21769591 - a(CHEBI:"AICA ribonucleotide") increases act(p(FPLX:AMPK)) + p(HGNC:APOE, var("p.Arg132Ser")) directlyDecreases act(p(HGNC:APOE)) - pmid:22419736 + pubmed:18191876 - a(CHEBI:"AICA ribonucleotide") increases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) + p(HGNC:A2M, var("p.Val1000Ile")) association path(MESH:"Alzheimer Disease") + + - pmid:22419736 + pubmed:26195256 - a(CHEBI:"AICA ribonucleotide") decreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + p(HGNC:A2M) decreases a(CHEBI:amyloid-beta) - pmid:22419736 + pubmed:18191876 - a(CHEBI:"AICA ribonucleotide") decreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + g(DBSNP:rs669) association path(MESH:"Alzheimer Disease") - pmid:30116051 + pubmed:18191876 - a(PUBCHEM:54708532) increases act(p(FPLX:AMPK)) + g(DBSNP:rs669) association path(MESH:"Alzheimer Disease") - pmid:30116051 + pubmed:18191876 - a(PUBCHEM:54708532) increases deg(p(HGNC:HTT, var("?"))) + p(HGNC:OLR1) association path(MESH:"Alzheimer Disease") - pmid:30116051 + pubmed:18191876 - a(PUBCHEM:54708532) increases bp(GO:macroautophagy) + p(HGNC:OLR1) association path(MESH:"Alzheimer Disease") - pmid:30116051 + pubmed:20693622 - a(CHEBI:"selenium(2+)") negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:CYP46A1) increases a(CHEBI:24-hydroxycholesterol) - pmid:30116051 + pubmed:20693622 - a(CHEBI:selenomethionine) increases bp(GO:autophagy) + p(HGNC:CYP46A1) association path(MESH:"Alzheimer Disease") - pmid:30116051 + pubmed:20693622 - a(CHEBI:selenomethionine) increases act(p(FPLX:AMPK)) + p(HGNC:CYP46A1) association g(DBSNP:rs3783320) - pmid:30116051 + pubmed:20693622 - a(CHEBI:selenomethionine) increases bp(GO:"autophagosome assembly") + g(DBSNP:rs8003602) association g(HGNC:CYP46A1) - pmid:30116051 + pubmed:20693622 - a(CHEBI:selenomethionine) increases bp(GO:"lysosomal microautophagy") + g(DBSNP:rs8003602) association path(MESH:"Alzheimer Disease") - + + + pubmed:20693622 + + g(HGNC:CYP46A1) association g(DBSNP:rs8003602) + - pmid:30116051 + pubmed:20693622 - composite(a(CHEBI:"calcium(2+)"), p(HGNC:CAMKK2)) increases p(FPLX:AMPK, pmod(Ph, Thr, 172)) + g(DBSNP:rs3783320) association p(HGNC:CYP46A1) - pmid:22419736 + pubmed:20693622 - p(FPLX:AMPK, pmod(Ph, Thr, 172)) negativeCorrelation path(MESH:"Alzheimer Disease") + g(DBSNP:rs3783320) association path(MESH:"Alzheimer Disease") - pmid:22419736 + pubmed:20693622 - p(FPLX:AMPK, pmod(Ph, Thr, 172)) negativeCorrelation p(HGNC:AK1) + act(p(HGNC:MYT1), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases g(HGNC:CYP46A1) - pmid:30116051 + pubmed:19926167 - a(CHEBI:metformin) increases act(p(FPLX:AMPK)) + g(DBSNP:rs17571) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:30116051 + pubmed:21892414 - a(CHEBI:metformin) increases bp(GO:macroautophagy) + p(HGNC:CLU) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:30116051 + pubmed:22159054 - a(CHEBI:metformin) increases bp(MESH:Longevity) + p(HGNC:CLU) association path(MESH:"Alzheimer Disease") - pmid:30116051 + pubmed:21543606 - a(CHEBI:metformin) decreases a(CHEBI:"amyloid-beta") + p(HGNC:CLU) association g(DBSNP:rs11136000) - pmid:30116051 + pubmed:21543606 - a(CHEBI:metformin) decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + p(HGNC:CLU) decreases a(NIFT:"Fractional anisotropy") - pmid:30116051 + pubmed:21543606 - a(CHEBI:metformin) decreases bp(GO:"neuron death") + p(HGNC:CLU) association p(HGNC:APP, frag("672_713")) + + - pmid:30116051 + pubmed:21892414 - a(CHEBI:calcitriol) increases act(p(FPLX:AMPK)) + g(DBSNP:rs9331888) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:30116051 + pubmed:19734903 - a(CHEBI:calcitriol) increases bp(GO:macroautophagy) + g(DBSNP:rs9331888) association g(HGNC:CLU) - pmid:29626319 + pubmed:22244847 - a(CHEBI:calcitriol) increases tloc(a(CHEBI:"amyloid-beta polypeptide 40"), fromLoc(MESH:Brain), toLoc(MESH:Blood)) + p(HGNC:CR1) increases bp(GO:"long-term synaptic depression") + + - pmid:29626319 + pubmed:22244847 - a(CHEBI:calcitriol) decreases p(HGNC:AGER) + g(DBSNP:rs6656401) increases bp(GO:"long-term synaptic depression") - pmid:29626319 + pubmed:22262751 - a(CHEBI:calcitriol) increases p(HGNC:LRP1) + g(DBSNP:rs6656401) association a(CHEBI:amyloid-beta) - - - - - pmid:30116051 + pubmed:19734903 - complex(a(CHEBI:sirolimus), p(HGNC:FKBP1A)) decreases act(p(FPLX:mTORC1)) + g(DBSNP:rs6656401) association path(MESH:"Alzheimer Disease") - pmid:23832849 + pubmed:19734903 - p(HGNC:FKBP1A) association a(GO:"neurofibrillary tangle") + g(DBSNP:rs6656401) association g(HGNC:CLU) - pmid:23832849 + pubmed:24162737 - p(HGNC:FKBP1A) decreases a(HBP:"Tau aggregates") + g(DBSNP:rs6656401) association g(HGNC:CR1) - pmid:23832849 + pubmed:19734903 - p(HGNC:FKBP1A) decreases a(HBP:"Tau oligomers") + g(DBSNP:rs6656401) association g(HGNC:CR1) - pmid:26631930 + pubmed:22410445 - p(HGNC:FUS) decreases p(HBP:"4R tau") + g(HGNC:SORL1) association bp(GO:"pre-B cell receptor expression") - pmid:26631930 + pubmed:17975299 - p(HGNC:FUS) decreases p(HBP:"Tau isoform F (441 aa)") + g(HGNC:SORL1) association path(MESH:"Alzheimer Disease") - pmid:26631930 + pubmed:24162737 - p(HGNC:FUS) decreases p(HBP:"Tau isoform C (410 aa)") + g(HGNC:SORL1) association g(DBSNP:rs11218343) - pmid:26631930 + pubmed:23565137 - p(HGNC:FUS) association path(MESH:"Frontotemporal Lobar Degeneration") + g(HGNC:SORL1) association g(DBSNP:rs11218343) - - - pmid:27181519 + pubmed:" 26517285" - p(HGNC:FUS) regulates bp(MESH:"Transcription, Genetic") + g(HGNC:SORL1) association bp(GO:endocytosis) - pmid:27181519 + pubmed:" 26517285" - p(HGNC:FUS) association bp(GO:"RNA splicing") + g(HGNC:SORL1) association bp(GO:"lipid metabolic process") - pmid:27181519 + pubmed:26996954 - p(HGNC:FUS) association bp(GO:"DNA repair") + g(HGNC:SORL1) association g(DBSNP:rs3824968) - - - - - pmid:27181519 + pubmed:26996954 - p(HGNC:FUS, loc(GO:cytosol)) association complex(GO:"cytoplasmic stress granule") + g(HGNC:SORL1) association g(DBSNP:rs3824968) - pmid:27181519 + pubmed:26996954 - act(p(HGNC:FUS)) regulates a(CHEBI:"nucleic acid") + g(HGNC:SORL1) association path(MESH:"Cerebrovascular Disorders") - - - pmid:30116051 + pubmed:22410445 - a(CHEBI:fisetin) increases bp(GO:macroautophagy) + bp(GO:"pre-B cell receptor expression") association g(HGNC:SORL1) - pmid:30116051 + pubmed:22410445 - a(CHEBI:fisetin) increases act(p(FPLX:mTORC1)) + g(DBSNP:rs1699102) decreases bp(GO:"pre-B cell receptor expression") - pmid:30116051 + pubmed:22410445 - a(CHEBI:fisetin) decreases a(CHEBI:"amyloid-beta") + g(DBSNP:rs2070045) decreases bp(GO:"pre-B cell receptor expression") - pmid:30116051 + pubmed:22382309 - p(HGNC:ABL1) decreases bp(GO:macroautophagy) + g(HGNC:CD33) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:29191965 + pubmed:22167654 - p(HGNC:ABL1) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr)) + g(HGNC:CD33) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:26631930 + pubmed:21460841 - p(HGNC:ABL1) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 394)) + g(HGNC:CD33) association path(MESH:"Alzheimer Disease") - pmid:17493042 + pubmed:22382309 - p(HGNC:ABL1) increases p(HGNC:MAPT, pmod(Ph, Tyr, 394)) + g(HGNC:CD33) association g(DBSNP:rs3865444) - pmid:23687953 + pubmed:21460841 - act(p(HGNC:ABL1), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 363)) + g(HGNC:CD33) association g(DBSNP:rs3865444) - pmid:30116051 + pubmed:24162737 - a(CHEBI:nilotinib) decreases act(p(HGNC:ABL1)) + g(HGNC:CD33) association g(DBSNP:rs3865444) - pmid:30116051 + pubmed:21460841 - a(CHEBI:nilotinib) increases bp(GO:macroautophagy) + g(HGNC:CD33) association g(DBSNP:rs3865444) - pmid:30116051 + pubmed:22167654 - a(CHEBI:nilotinib) decreases bp(HP:Neurodegeneration) + g(HGNC:CD33) association g(DBSNP:rs3826656) - pmid:30116051 + pubmed:18976728 - a(CHEBI:cilostazol) decreases a(CHEBI:"amyloid-beta polypeptide 42") + g(HGNC:CD33) association g(DBSNP:rs3826656) - pmid:30116051 + pubmed:" 26517285" - a(CHEBI:cilostazol) increases bp(GO:macroautophagy) + g(HGNC:CD33) association bp(GO:"immune response") - pmid:30116051 + pubmed:22382309 - a(CHEBI:cilostazol) increases act(p(HGNC:BECN1)) + g(DBSNP:rs3865444) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:30116051 + pubmed:21460841 - a(CHEBI:cilostazol) increases act(p(HGNC:ATG5)) + g(DBSNP:rs3865444) association path(MESH:"Alzheimer Disease") - pmid:30116051 + pubmed:22382309 - a(CHEBI:cilostazol) increases act(p(HGNC:MAP1LC3A)) + g(DBSNP:rs3865444) association g(HGNC:CD33) - pmid:30116051 + pubmed:21460841 - a(CHEBI:cilostazol) decreases act(p(FPLX:mTORC1)) + g(DBSNP:rs3865444) association g(HGNC:CD33) - pmid:30116051 + pubmed:24162737 - a(CHEBI:cilostazol) increases p(HGNC:CTSB) + g(DBSNP:rs3865444) association g(HGNC:CD33) - pmid:30116051 + pubmed:21460841 - a(CHEBI:cilostazol) increases act(p(HGNC:SIRT1)) + g(DBSNP:rs3865444) association g(HGNC:CD33) - pmid:30116051 + pubmed:22382309 - a(CHEBI:cilostazol) increases p(FPLX:AMPK, pmod(Ph, Tyr, 172)) + g(HGNC:MS4A6A) positiveCorrelation path(MESH:"Alzheimer Disease") - - - - - pmid:30116051 + pubmed:22382309 - composite(a(CHEBI:cilostazol), a(MESH:"amyloid beta-protein (25-35)")) increases bp(GO:cognition) + g(HGNC:MS4A6A) association g(DBSNP:rs610932) - pmid:30116051 + pubmed:21460840 - composite(a(CHEBI:cilostazol), a(MESH:"amyloid beta-protein (25-35)")) decreases a(CHEBI:"amyloid-beta polypeptide 42") + g(HGNC:MS4A6A) association g(DBSNP:rs610932) - pmid:30116051 + pubmed:21627779 - composite(a(CHEBI:cilostazol), a(MESH:"amyloid beta-protein (25-35)")) decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + g(HGNC:MS4A6A) association g(DBSNP:rs1562990) - pmid:30116051 + pubmed:21460841 - a(CHEBI:spermidine) decreases p(HGNC:ATG7, pmod(Ac)) + g(HGNC:MS4A6A) association g(DBSNP:rs4938933) - pmid:30116051 + pubmed:22382309 - a(CHEBI:spermidine) decreases p(FPLX:"Histone_H3", pmod(Ac)) + g(DBSNP:rs610932) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:30116051 + pubmed:21460840 - a(CHEBI:spermidine) increases act(p(HGNC:BECN1)) + g(DBSNP:rs610932) association path(MESH:"Alzheimer Disease") - pmid:30116051 + pubmed:22382309 - a(CHEBI:spermidine) decreases act(p(HGNC:CASP3)) + g(DBSNP:rs610932) association g(HGNC:MS4A6A) - - - pmid:30116051 + pubmed:21460840 - a(CHEBI:Isorhynchophylline) increases act(p(HGNC:BECN1)) + g(DBSNP:rs610932) association g(HGNC:MS4A6A) - pmid:30116051 + pubmed:21460840 - a(CHEBI:Isorhynchophylline) increases deg(p(HGNC:SNCA)) + g(DBSNP:rs610932) association g(HGNC:MS4A1) - pmid:30116051 + pubmed:22167654 - a(CHEBI:Isorhynchophylline) increases bp(GO:macroautophagy) + g(DBSNP:rs3826656) positiveCorrelation path(MESH:"Alzheimer Disease") - - - - - pmid:30116051 + pubmed:22167654 - complex(p(HGNC:BCL2), p(HGNC:BECN1)) decreases bp(GO:macroautophagy) + g(DBSNP:rs3826656) association g(HGNC:CD33) - pmid:30116051 + pubmed:18976728 - a(PUBCHEM:16240819) decreases act(p(HGNC:MTMR14)) + g(DBSNP:rs3826656) association g(HGNC:CD33) - pmid:30116051 + pubmed:22167654 - a(PUBCHEM:16240819) increases bp(GO:macroautophagy) + g(HGNC:GOLM1) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:30116051 + pubmed:22167654 - a(PUBCHEM:16240819) decreases bp(HP:Neurodegeneration) + g(HGNC:GOLM1) association g(DBSNP:rs10868366) - pmid:30116051 + pubmed:22167654 - p(HGNC:MTMR14) decreases act(p(FPLX:PI3K)) + g(HGNC:GOLM1) association g(DBSNP:rs7019241) - pmid:30116051 + pubmed:22167654 - a(CHEBI:"epothilone A") increases a(GO:microtubule) + g(DBSNP:rs10868366) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:30116051 + pubmed:22167654 - a(CHEBI:"epothilone D") increases a(GO:microtubule) + g(DBSNP:rs10868366) association g(HGNC:GOLM1) - pmid:30116051 + pubmed:22167654 - a(CHEBI:"epothilone D") increases bp(GO:cognition) + g(DBSNP:rs7019241) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:30116051 + pubmed:22167654 - a(PUBCHEM:129688311) increases bp(GO:"lysosomal lumen acidification") + g(DBSNP:rs7019241) association g(HGNC:GOLM1) - pmid:30116051 + pubmed:21285854 - a(PUBCHEM:129688311) decreases p(HGNC:SNCA) + g(HGNC:GAB2) association path(MESH:"Alzheimer Disease") - pmid:30116051 + pubmed:17553421 - a(PUBCHEM:129688311) decreases a(CHEBI:"amyloid-beta") + g(HGNC:GAB2) association path(MESH:"Alzheimer Disease") - pmid:30116051 + pubmed:21285854 - a(CHEBI:"poly(lactic acid) polymer") increases bp(GO:"lysosomal lumen acidification") + g(HGNC:GAB2) association g(DBSNP:rs4945261) - pmid:30116051 + pubmed:21285854 - a(CHEBI:"poly(D,L-lactic acid-co-glycolic acid)") increases bp(GO:"lysosomal lumen acidification") + g(HGNC:GAB2) association g(DBSNP:rs7101429) - pmid:30116051 + pubmed:21285854 - a(PUBCHEM:2880983) increases act(p(HGNC:MCOLN1)) + g(HGNC:GAB2) association g(DBSNP:rs7115850) - pmid:30116051 + pubmed:17553421 - act(p(HGNC:MCOLN1)) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:Lysosomes), toLoc(MESH:Cytoplasm)) + g(HGNC:GAB2) association g(DBSNP:rs2373115) - pmid:30116051 + pubmed:17553421 - act(p(HGNC:MCOLN1)) increases bp(GO:"lysosomal lumen acidification") + g(HGNC:GAB2) association g(DBSNP:rs2373115) - pmid:30116051 + pubmed:21285854 - act(p(HGNC:MCOLN1)) decreases a(CHEBI:"amyloid-beta") + g(DBSNP:rs4945261) association g(HGNC:GAB2) - pmid:30116051 + pubmed:21285854 - a(CHEBI:chlorohydroquinone) decreases bp(GO:macroautophagy) + g(DBSNP:rs4945261) association path(MESH:"Alzheimer Disease") - pmid:30116051 + pubmed:21285854 - a(CHEBI:"5-chloro-7-iodoquinolin-8-ol") increases bp(GO:macroautophagy) + g(DBSNP:rs7101429) association g(HGNC:GAB2) - pmid:30116051 + pubmed:21285854 - a(CHEBI:"5-chloro-7-iodoquinolin-8-ol") decreases a(CHEBI:"amyloid-beta polypeptide 42") + g(DBSNP:rs7101429) association path(MESH:"Alzheimer Disease") - pmid:30116051 + pubmed:21285854 - a(CHEBI:"5-chloro-7-iodoquinolin-8-ol") decreases a(HBP:"amyloid-beta aggregates") + g(DBSNP:rs7115850) association g(HGNC:GAB2) - pmid:30116051 + pubmed:21285854 - a(CHEBI:ambroxol) increases p(HGNC:GBA) + g(DBSNP:rs7115850) association path(MESH:"Alzheimer Disease") - pmid:30116051 + pubmed:22159054 - a(CHEBI:ambroxol) increases bp(GO:macroautophagy) + p(HGNC:NECTIN2) association path(MESH:"Alzheimer Disease") - pmid:30116051 + pubmed:22159054 - a(CHEBI:ambroxol) increases deg(p(HGNC:SNCA)) + g(DBSNP:rs6859) association path(MESH:"Alzheimer Disease") - pmid:30116051 + pubmed:22159054 - a(CHEBI:ambroxol) decreases p(HGNC:SNCA) + g(DBSNP:rs6859) association g(HGNC:NECTIN2) - pmid:30116051 + pubmed:18823527 - a(CHEBI:ambroxol) decreases bp(GO:"response to endoplasmic reticulum stress") + g(DBSNP:rs6859) association g(HGNC:NECTIN2) - pmid:30116051 + pubmed:20885792 - a(PUBCHEM:9568077) increases act(p(HGNC:HSF1), ma(tscript)) + g(DBSNP:rs6859) association g(HGNC:NECTIN2) - pmid:30116051 + pubmed:22159054 - a(PUBCHEM:46216556) decreases act(p(FPLX:HSP90)) + p(HGNC:PICALM) association path(MESH:"Alzheimer Disease") - pmid:30116051 + pubmed:29626319 - a(PUBCHEM:46216556) decreases a(HBP:"huntingtin aggregates") + p(HGNC:PICALM) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:30116051 + pubmed:27260836 - a(PUBCHEM:46216556) increases path(MESH:"Motor Activity") + p(HGNC:PICALM) negativeCorrelation path(MESH:"Alzheimer Disease") + + - pmid:30116051 + pubmed:29758300 - a(PUBCHEM:3086599) increases act(complex(GO:"proteasome complex")) + p(HGNC:PICALM) positiveCorrelation a(CHEBI:amyloid-beta) - pmid:30116051 + pubmed:29758300 - a(PUBCHEM:3086599) increases act(p(FPLX:PKA), ma(kin)) + p(HGNC:PICALM) increases a(CHEBI:amyloid-beta) - pmid:30116051 + pubmed:29758300 - p(HGNC:PSMC5, pmod(Ph, Ser, 120)) increases act(complex(GO:"proteasome complex")) + p(HGNC:PICALM) increases tloc(a(CHEBI:amyloid-beta), fromLoc(MESH:"Endothelial Cells"), toLoc(MESH:Blood)) - - - - - - - pmid:30116051 + pubmed:29626319 - complex(p(HGNC:BIRC2), p(HGNC:SOD1)) increases deg(p(HGNC:SOD1)) + p(HGNC:PICALM) increases tloc(a(CHEBI:amyloid-beta), fromLoc(MESH:"Blood-Brain Barrier"), toLoc(MESH:Blood)) - pmid:23702978 + pubmed:29626319 - p(HGNC:BIRC2) decreases complex(GO:ripoptosome) + p(HGNC:PICALM) decreases a(CHEBI:amyloid-beta) - pmid:30116051 + pubmed:29758300 - p(HGNC:SESN2) increases act(p(FPLX:AMPK)) + p(HGNC:PICALM) increases path(MESH:"Plaque, Amyloid") - pmid:30116051 + pubmed:29758300 - p(HGNC:SESN2) increases bp(GO:macroautophagy) + p(HGNC:PICALM) increases bp(GO:"clathrin-dependent endocytosis") - pmid:30116051 + pubmed:29758300 - p(HGNC:SESN2) increases bp(GO:macroautophagy) + p(HGNC:PICALM) increases tloc(complex(GO:"gamma-secretase complex"), fromLoc(GO:"extracellular space"), toLoc(GO:intracellular)) - pmid:30116051 + pubmed:29758300 - p(HGNC:SESN2) increases act(p(FPLX:mTORC1)) + p(HGNC:PICALM) regulates bp(GO:macroautophagy) - pmid:30116051 + pubmed:29758300 - p(HGNC:PLG) increases deg(a(CHEBI:"amyloid-beta polypeptide 42")) + p(HGNC:PICALM) increases tloc(complex(GO:"SNARE complex"), fromLoc(GO:"extracellular space"), toLoc(GO:intracellular)) - pmid:30116051 + pubmed:27260836 - p(HGNC:PLG) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:PICALM) increases complex(p(CONSO:"AP-2 complex"), p(HGNCGENEFAMILY:"Clathrin subunits")) + + - pmid:30116051 + pubmed:27260836 - p(HGNC:PLG) increases deg(p(HGNC:SNCA)) + p(HGNC:PICALM) association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:26195256 + pubmed:27260836 - p(HGNC:PLG) increases deg(a(CHEBI:"amyloid-beta", loc(GO:"extracellular region"))) + p(HGNC:PICALM) partOf path(CONSO:"granulovacuolar degeneration") - pmid:30116051 + pubmed:27260836 - p(HGNC:KLK6) increases p(HGNC:SNCA, frag("?")) + p(HGNC:PICALM) negativeCorrelation p(HGNC:MAP1LC3B) - pmid:30985105 + pubmed:27260836 - p(HGNC:SNCA, frag("?")) increases a(HBP:"alpha-synuclein aggregates") + p(HGNC:PICALM) positiveCorrelation p(HGNC:BECN1) - pmid:30116051 + pubmed:22159054 - a(CHEBI:"(-)-epigallocatechin") increases p(HGNC:IDE) + p(HGNC:BIN1) association path(MESH:"Alzheimer Disease") - pmid:30116051 + pubmed:29758300 - a(CHEBI:"(-)-epigallocatechin") increases sec(p(HGNC:IDE)) + p(HGNC:BIN1) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:30116051 + pubmed:29758300 - a(CHEBI:"(-)-epigallocatechin") increases act(p(HGNC:IDE)) + p(HGNC:BIN1) increases bp(GO:endocytosis) - pmid:30116051 + pubmed:29758300 - a(CHEBI:"(-)-epigallocatechin") increases p(HGNC:MME) + p(HGNC:BIN1) increases bp(GO:"amyloid precursor protein metabolic process") - pmid:30116051 + pubmed:29758300 - a(CHEBI:"(-)-epigallocatechin") increases sec(p(HGNC:MME)) + p(HGNC:BIN1) increases bp(GO:autophagy) - pmid:30116051 + pubmed:29758300 - a(CHEBI:"(-)-epigallocatechin") increases act(p(HGNC:MME)) + p(HGNC:BIN1) decreases a(CHEBI:amyloid-beta) - pmid:30116051 + pubmed:29758300 - a(CHEBI:somatostatin) increases p(HGNC:IDE) + p(HGNC:BIN1) positiveCorrelation path(MESH:Tauopathies) - pmid:30116051 + pubmed:22159054 - a(CHEBI:somatostatin) increases sec(p(HGNC:IDE)) + p(HGNC:EPHA1) association path(MESH:"Alzheimer Disease") - pmid:30116051 + pubmed:22159054 - a(CHEBI:somatostatin) increases act(p(HGNC:IDE)) + p(HGNC:MS4A7) association path(MESH:"Alzheimer Disease") - pmid:29626319 + pubmed:22159054 - a(CHEBI:somatostatin) increases p(HGNC:IDE) + p(HGNC:ABCA7) association path(MESH:"Alzheimer Disease") - pmid:30116051 + pubmed:23556446 - a(CHEBI:somatostatin) increases p(HGNC:MME) + p(HGNC:ABCA7) association path(MESH:"Alzheimer Disease") - pmid:30116051 + pubmed:29626319 - a(CHEBI:somatostatin) increases sec(p(HGNC:MME)) + p(HGNC:ABCA7) association bp(GO:phagocytosis) - pmid:30116051 + pubmed:29626319 - a(CHEBI:somatostatin) increases act(p(HGNC:MME)) + p(HGNC:ABCA7) regulates bp(GO:phagocytosis) - pmid:29626319 + pubmed:29626319 - a(CHEBI:somatostatin) increases deg(a(CHEBI:"amyloid-beta")) + p(HGNC:ABCA7) decreases a(CHEBI:amyloid-beta) - pmid:30116051 + pubmed:29626319 - p(HGNC:GRN) increases act(p(HGNC:MME)) + p(HGNC:ABCA7) decreases a(CHEBI:amyloid-beta) - pmid:30116051 + pubmed:29626319 - p(HGNC:GRN) decreases path(MESH:"Plaque, Amyloid") + p(HGNC:ABCA7) decreases p(HGNC:BACE1) - pmid:30116051 + pubmed:22159054 - a(CHEBI:rifampicin) increases deg(a(CHEBI:"amyloid-beta polypeptide 42")) + p(HGNC:CD33) association path(MESH:"Alzheimer Disease") - pmid:30116051 + pubmed:29626319 - a(CHEBI:rifampicin) increases act(p(HGNC:LRP1)) + p(HGNC:CD33) association bp(GO:phagocytosis) - pmid:30116051 + pubmed:29626319 - a(CHEBI:rifampicin) increases act(p(FPLX:"GPIb_IX_V")) + p(HGNC:CD33) decreases deg(a(CHEBI:amyloid-beta)) - pmid:30116051 + pubmed:10887109 - act(p(HGNC:AQP4)) increases deg(a(CHEBI:"amyloid-beta")) + p(HGNC:CD33) regulates path(MESH:Myelopoiesis) - - - pmid:29626319 - - p(HGNC:AQP4) association deg(a(CHEBI:"amyloid-beta")) - + - - - pmid:29626319 - - p(HGNC:AQP4) decreases a(CHEBI:"amyloid-beta") - + - - - pmid:29626319 - - p(HGNC:AQP4) decreases a(CHEBI:"amyloid-beta") - + + + + + + + + + + + + + + + - pmid:26195256 + pubmed:10887109 - act(p(HGNC:AQP4)) increases act(a(HBP:"Glymphatic System")) + p(HGNC:CD33) causesNoChange a(CHEBI:"calcium(2+)") + + - pmid:29626319 + pubmed:10887109 - p(HGNC:AQP4) increases a(HP:"glymphatic system") + p(HGNC:CD33) association act(p(HGNC:FCGR1A)) - pmid:29626319 + pubmed:22005930 - p(HGNC:AQP4) increases a(HP:"glymphatic system") + g(HGNC:SLC29A2) association path(MESH:"Alzheimer Disease") - pmid:23484434 + pubmed:22005930 - a(CHEBI:6872) decreases a(HBP:HBP00006) + g(HGNC:SLC29A2) association g(DBSNP:rs6834555) - pmid:23484434 + pubmed:22005930 - a(CHEBI:8028) causesNoChange a(HBP:HBP00006) + g(DBSNP:rs6834555) association path(MESH:"Alzheimer Disease") - pmid:23484434 + pubmed:22005930 - a(CHEBI:44932) causesNoChange a(HBP:HBP00006) + g(DBSNP:rs6834555) association g(HGNC:SLC29A2) - pmid:23484434 + pubmed:22005930 - a(CHEBI:3647) causesNoChange a(HBP:HBP00006) + g(HGNC:VSNL1) association path(MESH:"Alzheimer Disease") - pmid:23484434 + pubmed:22005930 - a(CHEBI:87637) decreases a(HBP:HBP00006) + g(HGNC:VSNL1) association g(DBSNP:rs4038131) - pmid:23484434 + pubmed:22005930 - a(CHEBI:22580) decreases a(HBP:HBP00006) + g(HGNC:VSNL1) association g(DBSNP:rs4038131) - pmid:23484434 + pubmed:22005930 - a(CHEBI:1457) decreases a(HBP:HBP00018) + g(DBSNP:rs4038131) association path(MESH:"Alzheimer Disease") - pmid:23484434 + pubmed:22005930 - a(CHEBI:10642) decreases a(HBP:HBP00018) + g(DBSNP:rs4038131) association g(HGNC:VSNL1) - pmid:23484434 + pubmed:22005930 - a(CHEBI:4806) decreases a(HBP:HBP00018) + g(DBSNP:rs4038131) association g(HGNC:VSNL1) - pmid:23484434 + pubmed:21460840 - a(CHEBI:4806) decreases a(HBP:HBP00006) + g(HGNC:ABCA7) association path(MESH:"Alzheimer Disease") - pmid:23484434 + pubmed:21460840 - a(CHEBI:74460) decreases a(HBP:HBP00018) + g(HGNC:ABCA7) association g(DBSNP:rs3764650) - pmid:23484434 + pubmed:21460840 - a(HBP:HBP00021) decreases a(HBP:HBP00018) + g(HGNC:ABCA7) association g(DBSNP:rs3764650) - pmid:23484434 + pubmed:24162737 - a(HBP:HBP00019) decreases a(HBP:HBP00018) + g(HGNC:ABCA7) association g(DBSNP:rs4147929) - pmid:23484434 + pubmed:21460841 - a(CHEBI:90) causesNoChange a(HBP:HBP00006) + g(HGNC:ABCA7) association g(DBSNP:rs3752246) - pmid:23484434 + pubmed:23571587 - a(CHEBI:18152) decreases a(HBP:HBP00006) + g(HGNC:ABCA7) association g(DBSNP:rs115550680) - pmid:23484434 + pubmed:" 26517285" - a(CHEBI:3441) decreases a(HBP:HBP00018) + g(HGNC:ABCA7) association bp(GO:"immune response") - pmid:23484434 + pubmed:" 26517285" - a(CHEBI:3441) decreases a(HBP:HBP00006) + g(HGNC:ABCA7) association bp(GO:"lipid transport") - pmid:23484434 + pubmed:21460840 - a(CHEBI:6710) decreases a(HBP:HBP00006) + g(DBSNP:rs3764650) association path(MESH:"Alzheimer Disease") - pmid:23484434 + pubmed:21460840 - a(CHEBI:6710) decreases a(HBP:HBP00018) + g(DBSNP:rs3764650) association g(HGNC:ABCA7) - - - - - pmid:23484434 + pubmed:21460840 - a(CHEBI:112284) decreases a(HBP:HBP00006) + g(DBSNP:rs3764650) association g(HGNC:ABCA7) - pmid:23484434 + pubmed:21460840 - a(HBP:HBP00020) decreases a(HBP:HBP00006) + g(HGNC:MS4A1) association path(MESH:"Alzheimer Disease") - pmid:29024336 + pubmed:21460840 - path(MESH:"Proteostasis Deficiencies") decreases deg(p(MGI:Mapt, var("p.Pro301Leu"))) + g(HGNC:MS4A1) association g(DBSNP:rs610932) - pmid:29024336 + pubmed:" 26517285" - bp(GO:"late endosomal microautophagy") increases deg(p(MGI:Mapt)) + g(HGNC:MS4A1) association bp(GO:"immune response") - pmid:29024336 + pubmed:18823527 - bp(GO:"late endosomal microautophagy") increases deg(p(MGI:Mapt)) + g(HGNC:LRAT) association path(MESH:"Alzheimer Disease") - pmid:29024336 + pubmed:18823527 - bp(GO:"late endosomal microautophagy") increases deg(a(HBP:HBP00053)) + g(HGNC:LRAT) association g(DBSNP:rs201825) - pmid:29024336 + pubmed:18823527 - p(MGI:Mapt, var("p.Pro301Leu")) decreases deg(p(MGI:Mapt)) + g(DBSNP:rs201825) association path(MESH:"Alzheimer Disease") - pmid:29024336 + pubmed:18823527 - p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Mapt) + g(DBSNP:rs201825) association g(HGNC:LRAT) - pmid:29024336 + pubmed:18823527 - p(MGI:Mapt, var("p.Pro301Leu")) decreases deg(p(MGI:Mapt)) + g(DBSNP:rs727153) association path(MESH:"Alzheimer Disease") - pmid:29024336 + pubmed:19734902 - p(MGI:Mapt, var("p.Pro301Leu")) decreases deg(p(MGI:Mapt)) + g(DBSNP:rs2075650) association path(MESH:"Alzheimer Disease") - pmid:29024336 + pubmed:20460622 - p(MGI:Mapt, var("p.Pro301Leu")) decreases deg(p(MGI:Mapt)) + g(DBSNP:rs2075650) association path(MESH:"Alzheimer Disease") - pmid:29024336 + pubmed:20061627 - p(MGI:Mapt, var("p.Pro301Leu")) increases a(HBP:HBP00006) + g(DBSNP:rs2075650) association path(MESH:"Alzheimer Disease") - pmid:29024336 + pubmed:20885792 - p(MGI:Mapt, var("p.Pro301Leu")) increases a(HBP:HBP00100) + g(DBSNP:rs2075650) association path(MESH:"Alzheimer Disease") - pmid:29024336 + pubmed:21123754 - p(MGI:Mapt, var("p.Pro301Leu")) decreases complex(a(GO:lysosome), p(MGI:Mapt)) + g(DBSNP:rs2075650) association path(MESH:"Alzheimer Disease") - pmid:29024336 + pubmed:19734902 - p(MGI:Mapt, var("p.Pro301Leu")) decreases complex(a(GO:lysosome), p(MGI:Mapt)) + g(DBSNP:rs2075650) association g(HGNC:APOE) - pmid:29024336 + pubmed:20460622 - p(MGI:Mapt, var("p.Pro301Leu")) decreases bp(GO:"late endosomal microautophagy") + g(DBSNP:rs2075650) association g(HGNC:APOE) - pmid:29024336 + pubmed:20885792 - p(MGI:Mapt, var("p.Pro301Leu")) decreases deg(p(MGI:Mapt, var("p.Pro301Leu"))) + g(DBSNP:rs2075650) association g(HGNC:APOE) - pmid:29024336 + pubmed:20061627 - p(MGI:Mapt, var("p.Pro301Leu")) increases deg(a(MESH:Proteins)) + g(DBSNP:rs2075650) association g(HGNC:TOMM40) - pmid:29024336 + pubmed:21123754 - p(MGI:Mapt, var("p.Pro301Leu")) increases deg(a(MESH:Proteins)) + g(DBSNP:rs2075650) association g(HGNC:TOMM40) - pmid:29024336 + pubmed:21123754 - p(MGI:Mapt, var("p.Pro301Leu")) increases bp(GO:"chaperone-mediated autophagy") + g(DBSNP:rs2075650) association g(HGNC:TOMM40) - pmid:29024336 + pubmed:19734902 - p(MGI:Mapt, var("p.Pro301Leu")) increases a(GO:autophagosome) + g(DBSNP:rs2075650) association g(HGNC:TOMM40) - pmid:29024336 + pubmed:19734903 - p(MGI:Mapt, var("p.Pro301Leu")) increases a(GO:autolysosome) + g(DBSNP:rs2075650) association g(HGNC:TOMM40) - pmid:29024336 + pubmed:20061627 - p(MGI:Mapt, var("p.Pro301Leu")) increases bp(GO:macroautophagy) + g(DBSNP:rs2075650) association g(HGNC:TOMM40) - pmid:29024336 + pubmed:20885792 - p(MGI:Mapt, var("p.Pro301Leu")) increases bp(GO:macroautophagy) + g(DBSNP:rs2075650) association g(HGNC:TOMM40) - pmid:30126037 + pubmed:20460622 - p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:H2afx) + g(DBSNP:rs2075650) association g(HGNC:TOMM40) - pmid:30126037 + pubmed:27004735 - p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Cdkn1a) + g(DBSNP:rs2075650) association p(HGNC:TOMM40) - pmid:30126037 + pubmed:19734902 - p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Cdkn2a) + g(HGNC:CLU) association path(MESH:"Alzheimer Disease") - pmid:30126037 + pubmed:19734903 - p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Il1b) + g(HGNC:CLU) association path(MESH:"Alzheimer Disease") - pmid:30126037 + pubmed:21627779 - p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Cxcl1) + g(HGNC:CLU) association path(MESH:"Alzheimer Disease") - pmid:30126037 + pubmed:21460841 - p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Tnf) + g(HGNC:CLU) association path(MESH:"Alzheimer Disease") - pmid:30126037 + pubmed:21379329 - p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Tlr4) + g(HGNC:CLU) association path(MESH:"Alzheimer Disease") - pmid:30126037 + pubmed:19734902 - p(MGI:Mapt, var("p.Pro301Leu")) increases bp(GO:"NIK/NF-kappaB signaling") + g(HGNC:CLU) association g(DBSNP:rs11136000) - pmid:30126037 + pubmed:21379329 - p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Rela) + g(HGNC:CLU) association g(DBSNP:rs11136000) - pmid:30126037 + pubmed:19734902 - p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Glb1) + g(HGNC:CLU) association g(DBSNP:rs11136000) - pmid:30126037 + pubmed:19734903 - p(MGI:Mapt, var("p.Pro301Leu")) increases path(MESH:Tauopathies) + g(HGNC:CLU) association g(DBSNP:rs11136000) - pmid:30126037 + pubmed:19734903 - p(MGI:Mapt, var("p.Pro301Leu")) increases a(GO:"neurofibrillary tangle") + g(HGNC:CLU) association g(DBSNP:rs6656401) - pmid:30126037 + pubmed:21627779 - p(MGI:Mapt, var("p.Pro301Leu")) increases bp(GO:"cellular senescence") + g(HGNC:CLU) association g(DBSNP:rs569214) - pmid:30126037 + pubmed:21627779 - p(MGI:Mapt, var("p.Pro301Leu")) association bp(MESH:"Cerebrovascular Circulation") + g(HGNC:CLU) association g(DBSNP:rs569214) - pmid:30126037 + pubmed:21460841 - p(MGI:Mapt, var("p.Pro301Leu")) increases bp(MESH:"Cerebrovascular Circulation") + g(HGNC:CLU) association g(DBSNP:rs1532278) - pmid:29121589 + pubmed:21460841 - p(MGI:Mapt, var("p.Pro301Leu")) increases path(HBP:Astrogliosis) + g(HGNC:CLU) association g(DBSNP:rs1532278) - pmid:29121589 + pubmed:24162737 - p(MGI:Mapt, var("p.Pro301Leu")) increases path(HBP:Microgliosis) + g(HGNC:CLU) association g(DBSNP:rs9331896) - pmid:29024336 + pubmed:19734903 - p(MGI:Mapt, var("p.Ala152Thr")) decreases deg(p(MGI:Mapt)) + g(HGNC:CLU) association g(DBSNP:rs2279590) - pmid:29024336 + pubmed:19734903 - p(MGI:Mapt, var("p.Ala152Thr")) increases p(MGI:Mapt) + g(HGNC:CLU) association g(DBSNP:rs9331888) - pmid:29024336 + pubmed:" 26517285" - p(MGI:Mapt, var("p.Ala152Thr")) decreases deg(p(MGI:Mapt)) + g(HGNC:CLU) association bp(GO:"immune response") - pmid:29024336 + pubmed:" 26517285" - p(MGI:Mapt, var("p.Ala152Thr")) decreases deg(p(MGI:Mapt)) + g(HGNC:CLU) association bp(GO:"lipid transport") - pmid:29024336 + pubmed:" 26517285" - p(MGI:Mapt, var("p.Ala152Thr")) increases a(HBP:HBP00009) + g(HGNC:CLU) association g(DBSNP:rs3824968) - pmid:29024336 + pubmed:19734902 - p(MGI:Mapt, var("p.Ala152Thr")) decreases bp(GO:"late endosomal microautophagy") + g(DBSNP:rs11136000) association path(MESH:"Alzheimer Disease") - pmid:29024336 + pubmed:19734903 - p(MGI:Mapt, var("p.Ala152Thr")) decreases bp(GO:"late endosomal microautophagy") + g(DBSNP:rs11136000) association path(MESH:"Alzheimer Disease") - pmid:29024336 + pubmed:21379329 - p(MGI:Mapt, var("p.Ala152Thr")) decreases deg(p(MGI:Mapt, var("p.Ala152Thr"))) + g(DBSNP:rs11136000) association path(MESH:"Alzheimer Disease") - pmid:29024336 + pubmed:21543606 - p(MGI:Mapt, var("p.Ala152Thr")) increases deg(a(MESH:Proteins)) + g(DBSNP:rs11136000) association path(MESH:"Alzheimer Disease") - pmid:29024336 + pubmed:19734902 - p(MGI:Mapt, var("p.Ala152Thr")) increases deg(a(MESH:Proteins)) + g(DBSNP:rs11136000) association g(HGNC:CLU) - pmid:29024336 + pubmed:21379329 - p(MGI:Mapt, var("p.Ala152Thr")) increases deg(a(MESH:Proteins)) + g(DBSNP:rs11136000) association g(HGNC:CLU) - pmid:29024336 + pubmed:19734902 - p(MGI:Mapt, var("p.Ala152Thr")) increases bp(GO:"chaperone-mediated autophagy") + g(DBSNP:rs11136000) association g(HGNC:CLU) - pmid:29024336 + pubmed:19734903 - p(MGI:Mapt, var("p.Ala152Thr")) increases a(GO:autophagosome) + g(DBSNP:rs11136000) association g(HGNC:CLU) - pmid:29024336 + pubmed:19734903 - p(MGI:Mapt, var("p.Ala152Thr")) increases a(GO:autolysosome) + g(DBSNP:rs11136000) association g(HGNC:APOE) - pmid:29024336 + pubmed:21543606 - p(MGI:Mapt, var("p.Ala152Thr")) increases bp(GO:macroautophagy) + g(DBSNP:rs11136000) association p(HGNC:CLU) - pmid:29024336 + pubmed:19136949 - p(MGI:Mapt, var("p.Ala152Thr")) increases bp(GO:macroautophagy) + g(HGNC:PCDH11X) association path(MESH:"Alzheimer Disease") - - - - - - - - - pmid:29024336 + pubmed:19136949 - complex(a(GO:lysosome), p(MGI:Mapt, var("p.Pro301Leu"))) increases tloc(p(MGI:Mapt, var("p.Pro301Leu")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) + g(HGNC:PCDH11X) association g(DBSNP:rs5984894) - - - - - pmid:29024336 + pubmed:19136949 - complex(a(GO:lysosome), p(MGI:Snca, var("?"))) decreases tloc(p(MGI:Snca, var("?")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) + g(HGNC:PCDH11X) association g(DBSNP:rs2573905) - - - - - - - pmid:29024336 + pubmed:19136949 - complex(a(GO:lysosome), p(MGI:Lrrk2, var("?"))) decreases tloc(p(MGI:Lrrk2, var("?")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) + g(DBSNP:rs5984894) association path(MESH:"Alzheimer Disease") - - - - - - - pmid:29024336 + pubmed:19136949 - a(CHEBI:paraquat) increases bp(GO:"response to oxidative stress") + g(DBSNP:rs5984894) association g(HGNC:PCDH11X) - pmid:28019679 + pubmed:19118814 - a(CHEBI:paraquat) increases act(complex(GO:"NLRP3 inflammasome complex")) + g(HGNC:FAM13B) association path(MESH:"Alzheimer Disease") - pmid:28019679 + pubmed:19118814 - a(CHEBI:paraquat) increases p(HGNC:CASP1) + g(HGNC:FAM13B) association g(DBSNP:rs11610206) - pmid:28019679 + pubmed:19118814 - a(CHEBI:paraquat) increases p(HGNC:IL1B) + g(DBSNP:rs11610206) association path(MESH:"Alzheimer Disease") - - - - - pmid:29024336 + pubmed:19118814 - composite(a(CHEBI:thapsigargin), a(HBP:HBP00053)) increases bp(GO:"chaperone-mediated autophagy") + g(DBSNP:rs11610206) association g(HGNC:FAM13B) - - - - - pmid:29024336 + pubmed:18976728 - composite(a(CHEBI:paraquat), a(HBP:HBP00053)) increases bp(GO:"chaperone-mediated autophagy") + g(DBSNP:rs11159647) association path(MESH:"Alzheimer Disease") - - - - - pmid:29024336 + pubmed:22005931 - composite(a(CHEBI:paraquat), p(MGI:Mapt, var("p.Pro301Leu"))) decreases bp(GO:"chaperone-mediated autophagy") + g(HGNC:DCHS2) association path(MESH:"Alzheimer Disease") - - - - - pmid:29024336 + pubmed:22005931 - composite(a(CHEBI:thapsigargin), p(MGI:Mapt, var("p.Pro301Leu"))) decreases bp(GO:"chaperone-mediated autophagy") + g(HGNC:DCHS2) association g(DBSNP:rs1466662) - - - - - pmid:29024336 + pubmed:22005931 - composite(a(CHEBI:thapsigargin), p(MGI:Mapt, var("p.Ala152Thr"))) causesNoChange bp(GO:"chaperone-mediated autophagy") + g(HGNC:DCHS2) association g(DBSNP:rs1466662) - - - - - pmid:29024336 + pubmed:22005931 - composite(a(CHEBI:paraquat), p(MGI:Mapt, var("p.Ala152Thr"))) causesNoChange bp(GO:"chaperone-mediated autophagy") + g(DBSNP:rs1466662) association path(MESH:"Alzheimer Disease") - - - - - pmid:29024336 + pubmed:22005931 - composite(a(CHEBI:"ammonium chloride"), a(CHEBI:leupeptin)) decreases bp(GO:"late endosomal microautophagy") + g(DBSNP:rs1466662) association g(HGNC:DCHS2) - pmid:23528736 + pubmed:22005931 - a(CHEBI:leupeptin) decreases act(p(FPLX:Proteasome)) + g(DBSNP:rs1466662) association g(HGNC:DCHS2) - pmid:23528736 + pubmed:21627779 - a(CHEBI:leupeptin) decreases deg(p(HGNC:MAPT)) + g(DBSNP:rs569214) association path(MESH:"Alzheimer Disease") - pmid:29024336 + pubmed:21627779 - a(HBP:HBP00057) increases tloc(p(MGI:Mapt), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) + g(DBSNP:rs569214) association g(HGNC:CLU) - pmid:29024336 + pubmed:21627779 - a(HBP:HBP00057) increases bp(GO:"chaperone-mediated autophagy") + g(DBSNP:rs569214) association g(HGNC:CLU) - pmid:29024336 + pubmed:21627779 - a(HBP:HBP00055) increases tloc(p(MGI:Mapt), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) + g(DBSNP:rs536841) association path(MESH:"Alzheimer Disease") - pmid:29024336 + pubmed:21627779 - a(HBP:HBP00055) decreases deg(p(MGI:Mapt)) + g(DBSNP:rs536841) association g(HGNC:PICALM) - pmid:29024336 + pubmed:21627779 - a(HBP:HBP00055) decreases bp(GO:"late endosomal microautophagy") + g(DBSNP:rs536841) association g(HGNC:PICALM) - pmid:29024336 + pubmed:21627779 - a(HBP:HBP00054) decreases tloc(p(MGI:Mapt), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) + g(DBSNP:rs1562990) association path(MESH:"Alzheimer Disease") - pmid:29024336 + pubmed:21627779 - p(HBP:HBP00053, var("p.Lys280del")) increases a(HBP:HBP00006) + g(DBSNP:rs1562990) association g(HGNC:MS4A6A) - pmid:29024336 + pubmed:20061627 - p(HBP:HBP00053, var("p.Lys280del")) decreases deg(p(HGNC:MAPT)) + g(HGNC:TOMM40) association path(MESH:"Alzheimer Disease") - pmid:29024336 + pubmed:21123754 - p(HBP:HBP00053, var("p.Lys280del")) decreases tloc(p(HBP:HBP00053, var("p.Lys280del")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) + g(HGNC:TOMM40) association path(MESH:"Alzheimer Disease") - pmid:29024336 + pubmed:20061627 - p(HBP:HBP00053, var("p.Lys280delinsProPro")) increases tloc(p(HBP:HBP00053, var("p.Lys280del")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) + g(HGNC:TOMM40) association g(DBSNP:rs2075650) - pmid:29024336 + pubmed:21123754 - p(HBP:HBP00053, var("p.Lys280delinsProPro")) decreases a(HBP:HBP00006) + g(HGNC:TOMM40) association g(DBSNP:rs2075650) - pmid:29024336 + pubmed:21123754 - p(HBP:HBP00053, var("p.Lys280delinsProPro")) decreases tloc(p(HBP:HBP00053, var("p.Lys280Pro")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) + g(HGNC:TOMM40) association g(DBSNP:rs2075650) - pmid:29024336 + pubmed:19734902 - p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) decreases tloc(p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) + g(HGNC:TOMM40) association g(DBSNP:rs2075650) - pmid:29024336 + pubmed:19734903 - p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) decreases deg(p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))) + g(HGNC:TOMM40) association g(DBSNP:rs2075650) - pmid:29024336 + pubmed:20061627 - p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212)) decreases tloc(p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212)), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) + g(HGNC:TOMM40) association g(DBSNP:rs2075650) - pmid:29024336 + pubmed:20885792 - p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212)) decreases deg(p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212))) + g(HGNC:TOMM40) association g(DBSNP:rs2075650) - pmid:29024336 + pubmed:20460622 - p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) decreases tloc(p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) + g(HGNC:TOMM40) association g(DBSNP:rs2075650) - pmid:29024336 + pubmed:21627779 - p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) decreases deg(p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404))) + g(HGNC:TOMM40) association g(DBSNP:rs157580) - pmid:29024336 + pubmed:21123754 - p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu")) decreases tloc(p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) + g(HGNC:TOMM40) association g(DBSNP:rs157580) - pmid:29024336 + pubmed:19125160 - p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu")) decreases deg(p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu"))) + g(HGNC:TOMM40) association g(DBSNP:rs157580) - pmid:29024336 + pubmed:23419831 - p(HBP:HBP00053, var("p.Ser262Ala"), var("p.Ser293Ala"), var("p.Ser324Ala"), var("p.Ser356Ala")) increases tloc(p(HBP:HBP00053, var("p.Ser262Ala"), var("p.Ser293Ala"), var("p.Ser324Ala"), var("p.Ser356Ala")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) + g(HGNC:TOMM40) association g(DBSNP:rs59007384) - pmid:29215007 + pubmed:21460841 - a(HBP:HBP00166) increases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) + g(DBSNP:rs5616655) association path(MESH:"Alzheimer Disease") - - - - - pmid:29215007 + pubmed:21460841 - complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) positiveCorrelation a(HBP:HBP00169) + g(DBSNP:rs5616655) association g(HGNC:PICALM) - - - - - - - - - - - - - - - pmid:29215007 + pubmed:21460841 - composite(complex(GO:"filamentous actin"), p(HGNC:CFL1)) decreases complex(GO:"filamentous actin") + g(HGNC:MS4A4A) association path(MESH:"Alzheimer Disease") - - - pmid:24760868 + pubmed:21460841 - complex(GO:"filamentous actin") association p(HGNC:MAPT) + g(HGNC:MS4A4A) association g(DBSNP:rs4938933) - pmid:24760868 + pubmed:21460841 - complex(GO:"filamentous actin") increases p(HGNC:MAPT) + g(DBSNP:rs4938933) association path(MESH:"Alzheimer Disease") - pmid:24760868 + pubmed:21460841 - complex(GO:"filamentous actin") increases p(HGNC:MAPT, loc(GO:synapse)) + g(DBSNP:rs4938933) association g(HGNC:MS4A4A) - pmid:17187063 + pubmed:21460841 - complex(GO:"filamentous actin") increases complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) + g(DBSNP:rs4938933) association g(HGNC:MS4A6A) - pmid:19118186 + pubmed:21460841 - complex(GO:"filamentous actin") negativeCorrelation complex(p(MGI:Cdk5), p(MGI:Cdk5r1)) + g(DBSNP:rs7561528) association path(MESH:"Alzheimer Disease") - pmid:29215007 + pubmed:21379329 - a(HBP:HBP00169) positiveCorrelation complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) + g(DBSNP:rs7561528) association path(MESH:"Alzheimer Disease") - pmid:29215007 + pubmed:21460841 - a(HBP:HBP00169) positiveCorrelation complex(a(GO:"filamentous actin"), p(HGNC:CFL1)) + g(DBSNP:rs7561528) association g(HGNC:BIN1) - pmid:29215007 + pubmed:21379329 - a(HBP:HBP00169) positiveCorrelation complex(a(MESH:Actins), p(HGNC:CFL1)) + g(DBSNP:rs7561528) association g(HGNC:BIN1) - - - - - pmid:29215007 + pubmed:22832961 - complex(a(GO:"filamentous actin"), p(HGNC:CFL1)) positiveCorrelation a(HBP:HBP00169) + g(DBSNP:rs7561528) association g(HGNC:BIN1) - - - - - pmid:29215007 + pubmed:21460841 - complex(a(MESH:Actins), p(HGNC:CFL1)) positiveCorrelation a(HBP:HBP00169) + g(DBSNP:rs7561528) association g(HGNC:BIN1) - pmid:29215007 + pubmed:21460841 - a(MESH:Endopeptidases) increases p(HGNC:MAPT, var("?")) + g(DBSNP:rs6701713) association path(MESH:"Alzheimer Disease") - - - - - pmid:29215007 + pubmed:21460841 - p(HGNC:MAPT, frag("244_372")) increases bp(GO:"actin filament bundle assembly") + g(DBSNP:rs6701713) association g(HGNC:CR1) - pmid:29215007 + pubmed:21460841 - p(HGNC:MAPT, frag("254_290")) increases bp(GO:"actin filament bundle assembly") + g(DBSNP:rs6701713) association g(HGNC:CR1) - pmid:29215007 + pubmed:21460841 - p(HGNC:MAPT, frag("254_290")) increases bp(GO:"actin filament bundle assembly") + g(HGNC:CD2AP) association path(MESH:"Alzheimer Disease") - pmid:29215007 + pubmed:21460841 - p(HGNC:MAPT, frag("254_290")) increases complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_290"))) + g(HGNC:CD2AP) association g(DBSNP:rs9349407) - pmid:29215007 + pubmed:21460841 - p(HGNC:MAPT, frag("260_268")) increases bp(MESH:"Protein Structure, Secondary") + g(HGNC:CD2AP) association g(DBSNP:rs9349407) - pmid:29215007 + pubmed:24162737 - p(HGNC:MAPT, frag("277_283")) increases bp(MESH:"Protein Structure, Secondary") + g(HGNC:CD2AP) association g(DBSNP:rs10948363) - pmid:29215007 + pubmed:" 26517285" - p(HGNC:MAPT, frag("277_283")) increases bp(MESH:"Protein Conformation, alpha-Helical") + g(HGNC:CD2AP) association bp(GO:endocytosis) - pmid:29215007 + pubmed:21460841 - p(HGNC:MAPT, frag("261_268")) increases bp(MESH:"Protein Conformation, alpha-Helical") + g(DBSNP:rs9349407) association path(MESH:"Alzheimer Disease") - pmid:22072628 + pubmed:21460841 - bp(MESH:"Protein Conformation, alpha-Helical") positiveCorrelation p(HBP:"proline-rich region 2", pmod(Ph)) + g(DBSNP:rs9349407) association g(HGNC:CD2AP) - pmid:22072628 + pubmed:21460841 - bp(MESH:"Protein Conformation, alpha-Helical") association p(HGNC:MAPT, frag("235_324")) + g(DBSNP:rs9349407) association g(HGNC:CD2AP) - pmid:29215007 + pubmed:21460841 - p(HGNC:MAPT, frag("277_280")) increases a(HBP:HBP00170) + g(HGNC:EPHA1) association path(MESH:"Alzheimer Disease") - pmid:29215007 + pubmed:21460841 - p(HGNC:MAPT, frag("261_265")) increases a(HBP:HBP00170) + g(HGNC:EPHA1) association g(DBSNP:rs11767557) - - - - - pmid:29215007 + pubmed:" 26517285" - complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("261_268"))) increases bp(MESH:"Protein Conformation, alpha-Helical") + g(HGNC:EPHA1) association bp(GO:"immune response") - - - - - pmid:29215007 + pubmed:" 26517285" - complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("277_280"))) increases a(HBP:HBP00170) + g(HGNC:EPHA1) association bp(GO:endocytosis) - - - - - pmid:29215007 + pubmed:21460841 - complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("261_265"))) increases a(HBP:HBP00170) + g(DBSNP:rs11767557) association path(MESH:"Alzheimer Disease") - - - - - pmid:29215007 + pubmed:21460841 - complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("277_283"))) increases bp(MESH:"Protein Conformation, alpha-Helical") + g(DBSNP:rs11767557) association g(HGNC:EPHA1) - - - - - pmid:29215007 + pubmed:21460841 - p(HGNC:MAPT, var("p.Leu256Glu")) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_290"))) + g(DBSNP:rs1532278) association path(MESH:"Alzheimer Disease") - pmid:29215007 + pubmed:21460841 - p(HGNC:MAPT, var("p.Leu256Glu")) decreases bp(GO:"actin filament bundle assembly") + g(DBSNP:rs1532278) association g(HGNC:CLU) - - - - - pmid:29215007 + pubmed:21460841 - complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_290"))) increases bp(MESH:"Protein Conformation, alpha-Helical") + g(DBSNP:rs1532278) association g(HGNC:CLU) - - - - - - - - - pmid:29215007 + pubmed:21390209 - p(HGNC:MAPT, frag("292_319")) increases bp(GO:"actin filament bundle assembly") + g(DBSNP:rs12989701) association path(MESH:"Alzheimer Disease") - pmid:29215007 + pubmed:21390209 - p(HGNC:MAPT, frag("315_318")) increases a(HBP:HBP00170) + g(DBSNP:rs12989701) association g(HGNC:BIN1) - - - - - pmid:29215007 + pubmed:21390209 - complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_268"))) increases bp(MESH:"Protein Conformation, alpha-Helical") + g(DBSNP:rs12989701) association g(HGNC:BIN1) - pmid:29215007 + pubmed:21379329 - p(HGNC:MAPT, frag("254_268")) decreases bp(GO:"actin filament bundle assembly") + g(HGNC:CELF2) association path(MESH:"Alzheimer Disease") - pmid:29215007 + pubmed:21379329 - act(p(HGNC:MARK2), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + g(HGNC:CELF2) association g(DBSNP:rs201119) - pmid:29215007 + pubmed:21379329 - p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + g(DBSNP:rs201119) association path(MESH:"Alzheimer Disease") - pmid:21311567 + pubmed:21379329 - act(p(HGNC:MARK2)) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + g(DBSNP:rs201119) association g(HGNC:CELF2) - pmid:24251416 + pubmed:20885792 - act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + g(HGNC:MTHFD1L) association path(MESH:"Alzheimer Disease") - pmid:25031639 + pubmed:20885792 - p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + g(HGNC:MTHFD1L) association g(DBSNP:rs11754661) - pmid:23001711 + pubmed:20885792 - act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + g(HGNC:MTHFD1L) association g(DBSNP:rs11754661) - pmid:29215007 + pubmed:20885792 - act(p(HGNC:MARK2), ma(kin)) increases p(HBP:HBP00098, pmod(Ph)) + g(DBSNP:rs11754661) association path(MESH:"Alzheimer Disease") - pmid:29215007 + pubmed:20885792 - p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 293)) + g(DBSNP:rs11754661) association g(HGNC:MTHFD1L) - pmid:24251416 + pubmed:20885792 - act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 293)) + g(DBSNP:rs11754661) association g(HGNC:MTHFD1L) - pmid:29215007 + pubmed:17553421 - p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 305)) + g(DBSNP:rs2373115) association path(MESH:"Alzheimer Disease") - pmid:24251416 + pubmed:17553421 - act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 305)) + g(DBSNP:rs2373115) association g(HGNC:GAB2) - pmid:29215007 + pubmed:17553421 - p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 324)) + g(DBSNP:rs2373115) association g(HGNC:GAB2) - pmid:24251416 + pubmed:21123754 - act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 324)) + g(HGNC:EPC2) association path(MESH:"Alzheimer Disease") - pmid:29215007 + pubmed:21123754 - p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 356)) + g(HGNC:EPC2) association g(DBSNP:rs4499362) - pmid:24251416 + pubmed:21123754 - act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 356)) + g(HGNC:EPC2) association g(DBSNP:rs4499362) - pmid:25031639 + pubmed:21123754 - p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 356)) + g(HGNC:EPC2) association g(DBSNP:rs2121433) - pmid:29215007 + pubmed:21123754 - p(HGNC:MARK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 416)) + g(DBSNP:rs4499362) association path(MESH:"Alzheimer Disease") - pmid:24251416 + pubmed:21123754 - act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 416)) + g(DBSNP:rs4499362) association g(HGNC:EPC2) - pmid:21882945 + pubmed:21123754 - act(p(HGNC:MARK2)) directlyIncreases p(HGNC:MAPT, pmod(Ph)) + g(DBSNP:rs4499362) association g(HGNC:EPC2) - pmid:21882945 + pubmed:21123754 - act(p(HGNC:MARK2)) directlyIncreases p(HGNC:MAPT, pmod(Ph)) + g(HGNC:CCDC134) association path(MESH:"Alzheimer Disease") - pmid:21311567 + pubmed:21123754 - act(p(HGNC:MARK2)) decreases bp(GO:"microtubule polymerization") + g(HGNC:CCDC134) association g(DBSNP:rs7364180) - pmid:24251416 + pubmed:21123754 - act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 352)) + g(HGNC:CCDC134) association g(DBSNP:rs7364180) - pmid:24251416 + pubmed:21123754 - act(p(HGNC:MARK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 413)) + g(DBSNP:rs7364180) association path(MESH:"Alzheimer Disease") - - - pmid:29215007 + pubmed:21123754 - p(HGNC:MAPT, pmod(Ph, Ser, 293)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) + g(DBSNP:rs7364180) association g(HGNC:CCDC134) - pmid:29215007 + pubmed:21123754 - p(HGNC:MAPT, pmod(Ph, Ser, 293)) decreases bp(GO:"actin filament bundle assembly") + g(DBSNP:rs7364180) association g(HGNC:CCDC134) - pmid:17493042 + pubmed:23022416 - p(HGNC:MAPT, pmod(Ph, Ser, 293)) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) + composite(g(DBSNP:rs3818361), g(DBSNP:rs429358)) association path(MESH:"Alzheimer Disease") - pmid:17493042 + pubmed:22236693 - p(HGNC:MAPT, pmod(Ph, Ser, 293)) decreases bp(GO:"neurofibrillary tangle assembly") + p(HGNC:NTRK1) negativeCorrelation bp(GO:"apoptotic process") + + + + - pmid:24251416 + pubmed:18986241 - p(HGNC:MAPT, pmod(Ph, Ser, 293)) partOf p(HBP:"tubulin-binding repeat 2") + p(HGNC:NTRK1) negativeCorrelation path(MESH:"Cognition Disorders") - pmid:29215007 + pubmed:18986241 - p(HGNC:MAPT, pmod(Ph, Ser, 305)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) + p(HGNC:NTRK1) biomarkerFor path(MESH:"Alzheimer Disease") - pmid:29215007 + pubmed:18986241 - p(HGNC:MAPT, pmod(Ph, Ser, 305)) decreases bp(GO:"actin filament bundle assembly") + p(HGNC:NTRK1) decreases act(p(HGNC:BACE1)) + + + + - pmid:24251416 + pubmed:18986241 - p(HGNC:MAPT, pmod(Ph, Ser, 305)) partOf p(HBP:"tubulin-binding repeat 2") + complex(p(HGNC:NGF), p(HGNC:NGFR)) increases complex(p(HGNC:NGF), p(HGNC:NTRK1)) - pmid:29215007 + pubmed:22236693 - p(HGNC:MAPT, pmod(Ph, Ser, 324)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) + bp(GO:"regulation of cell death") association p(HGNC:NGFR) - pmid:29215007 + pubmed:22236693 - p(HGNC:MAPT, pmod(Ph, Ser, 324)) decreases bp(GO:"actin filament bundle assembly") + g(HGNC:NGFR) association g(DBSNP:rs2072446) - pmid:17493042 + pubmed:22236693 - p(HGNC:MAPT, pmod(Ph, Ser, 324)) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) + g(HGNC:NGFR) association g(DBSNP:rs741072) - pmid:17493042 + pubmed:22236693 - p(HGNC:MAPT, pmod(Ph, Ser, 324)) decreases bp(GO:"neurofibrillary tangle assembly") + g(HGNC:NGFR) association g(DBSNP:rs2072445) - pmid:28760828 + pubmed:22236693 - p(HGNC:MAPT, pmod(Ph, Ser, 324)) positiveCorrelation p(HBP:"Tau aggregates") + g(HGNC:NGFR) association g(DBSNP:rs734194) - pmid:29215007 + pubmed:22236693 - p(HGNC:MAPT, pmod(Ph, Ser, 356)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) + g(HGNC:NGFR) negativeCorrelation bp(GO:cognition) - pmid:29215007 + pubmed:22236693 - p(HGNC:MAPT, pmod(Ph, Ser, 356)) decreases bp(GO:"actin filament bundle assembly") + g(HGNC:NGFR) association path(MESH:Dementia) - pmid:26751493 + pubmed:22236693 - p(HGNC:MAPT, pmod(Ph, Ser, 356)) positiveCorrelation path(MESH:"Alzheimer Disease") + g(HGNC:NGFR) increases bp(GO:"apoptotic process") - pmid:17493042 + pubmed:22236693 - p(HGNC:MAPT, pmod(Ph, Ser, 356)) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) + g(DBSNP:rs2072446) association g(HGNC:NGFR) - pmid:17493042 + pubmed:22236693 - p(HGNC:MAPT, pmod(Ph, Ser, 356)) decreases bp(GO:"neurofibrillary tangle assembly") + g(DBSNP:rs2072446) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:21367866 + pubmed:22236693 - p(HGNC:MAPT, pmod(Ph, Ser, 356)) positiveCorrelation p(HGNC:CDC37) + g(DBSNP:rs2072446) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:22156579 + pubmed:22236693 - p(HGNC:MAPT, pmod(Ph, Ser, 356)) partOf p(HBP:"Tau epitope, 12E8") + g(DBSNP:rs741072) association g(HGNC:NGFR) - pmid:22833681 + pubmed:22236693 - p(HGNC:MAPT, pmod(Ph, Ser, 356)) positiveCorrelation p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) + g(DBSNP:rs741072) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:25031639 + pubmed:22236693 - p(HGNC:MAPT, pmod(Ph, Ser, 356)) decreases complex(p(HGNC:MAPT, pmod(Ph, Ser, 356)), p(HGNC:STUB1)) + g(DBSNP:rs2072445) association g(HGNC:NGFR) - pmid:29215007 + pubmed:22236693 - p(HGNC:MAPT, pmod(Ph, Ser, 416)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) + g(DBSNP:rs734194) association g(HGNC:NGFR) - pmid:29215007 + pubmed:22236693 - p(HGNC:MAPT, pmod(Ph, Ser, 416)) decreases bp(GO:"actin filament bundle assembly") + g(DBSNP:rs734194) decreases act(g(HGNC:NGFR)) - - - - - pmid:24027553 + pubmed:22236693 - p(HGNC:MAPT, pmod(Ac)) association path(MESH:"Neurofibrillary Tangles") + g(DBSNP:rs734194) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:27041503 + pubmed:22236693 - p(HGNC:MAPT, pmod(Ac)) negativeCorrelation p(HGNC:WWC1) + g(DBSNP:rs734194) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:20869593 + pubmed:22236693 - p(HGNC:MAPT, pmod(Ac)) positiveCorrelation p(HGNC:MAPT, pmod(Ph)) + g(DBSNP:rs734194) association bp(GO:"regulation of mRNA stability") - pmid:20869593 + pubmed:22236693 - p(HGNC:MAPT, pmod(Ac)) positiveCorrelation p(HBP:"Tau epitope, AT8") + g(DBSNP:rs734194) association bp(GO:"regulation of translation") - pmid:24027553 + pubmed:22236693 - p(HGNC:MAPT, pmod(HBP:nitration)) association path(MESH:"Neurofibrillary Tangles") + g(DBSNP:rs734194) decreases complex(p(HGNC:NGF), p(HGNC:NGFR)) - pmid:24027553 + pubmed:22236693 - p(HGNC:MAPT, frag("1_?")) association path(MESH:"Neurofibrillary Tangles") + g(DBSNP:rs734194) decreases complex(p(HGNC:APP, frag("672_713")), p(HGNC:NGFR)) - pmid:24027553 + pubmed:22236693 - p(HGNC:MAPT, frag("?_*")) association path(MESH:"Neurofibrillary Tangles") + g(DBSNP:rs734194) decreases p(HGNC:NGFR) - pmid:24027553 + pubmed:22236693 - act(p(HGNCGENEFAMILY:Aminopeptidases)) increases deg(p(HGNC:MAPT)) + g(RGD:Ngfr) association path(MESH:"Diabetes Mellitus, Type 2") - - - - - - - - - pmid:24027553 + pubmed:22236693 - act(a(CHEBI:Thrombin)) increases deg(p(HGNC:MAPT)) + complex(p(HGNC:APP, frag("672_713")), p(HGNC:NGFR)) increases bp(GO:"apoptotic process") - pmid:24027553 + pubmed:22236693 - act(a(CHEBI:Thrombin)) increases deg(p(HGNC:MAPT)) + bp(GO:"regulation of mRNA stability") association g(DBSNP:rs734194) - pmid:24027553 + pubmed:22236693 - a(CHEBI:Thrombin) increases bp(GO:coagulation) + bp(GO:"regulation of translation") association g(DBSNP:rs734194) - pmid:24027553 + pubmed:" 21047645" - a(CHEBI:Thrombin) increases path(HBP:"neurite retraction") + m(HGNC:MIR659) decreases r(HGNC:GRN) - pmid:24027553 + pubmed:" 21047645" - a(CHEBI:Thrombin) increases bp(GO:"apoptotic process") + r(HGNC:GRN) association g(DBSNP:rs5848) - pmid:24027553 + pubmed:19625741 - a(CHEBI:Thrombin) increases bp(GO:"apoptotic process") + r(HGNC:GRN) increases p(HGNC:GRN) - pmid:24027553 + pubmed:" 21047645" - a(CHEBI:Thrombin) increases a(HBP:"Tau aggregates") + g(DBSNP:rs5848) association r(HGNC:GRN) - pmid:24027553 + pubmed:19625741 - a(CHEBI:Thrombin, loc(MESH:Neurons)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:GRN) positiveCorrelation bp(GO:"neuron death") - pmid:24027553 + pubmed:30116051 - a(CHEBI:Thrombin, loc(MESH:Astrocytes)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:GRN) increases act(p(HGNC:MME)) - pmid:24027553 + pubmed:30116051 - a(CHEBI:Thrombin) association path(MESH:"Neurofibrillary Tangles") + p(HGNC:GRN) decreases path(MESH:"Plaque, Amyloid") + + - pmid:24027553 + pubmed:29183403 - act(a(CHEBI:Thrombin)) increases p(HGNC:MAPT, frag("1_?")) + g(DBSNP:rs142787485) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:24027553 + pubmed:29183403 - act(a(CHEBI:Thrombin)) causesNoChange p(HGNC:MAPT, frag("561_685")) + p(HGNC:RAB10) increases p(HGNC:APP, frag("672_713")) - pmid:24027553 + pubmed:29183403 - act(a(CHEBI:Thrombin)) increases deg(p(HGNC:MAPT, frag("561_685"))) + p(HGNC:RAB10) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:24027553 + pubmed:21709374 - act(a(CHEBI:Thrombin)) increases act(p(HGNCGENEFAMILY:Caspases)) + g(DBSNP:rs1050283) association g(HGNC:OLR1) - pmid:24027553 + pubmed:21709374 - act(p(HGNCGENEFAMILY:Calpains)) increases deg(p(HGNC:MAPT)) + g(DBSNP:rs1050283) association path(MESH:"Alzheimer Disease") - pmid:24027553 + pubmed:18191876 - act(p(HGNCGENEFAMILY:Calpains)) increases deg(p(HGNC:MAPT)) + g(DBSNP:rs1050283) association path(MESH:"Alzheimer Disease") - pmid:24027553 + pubmed:21709374 - act(p(HGNCGENEFAMILY:Calpains)) increases deg(p(HGNC:MAPT)) + g(HGNC:OLR1) association g(DBSNP:rs1050283) - - - - - pmid:24027553 + pubmed:21709374 - p(HGNCGENEFAMILY:Calpains) association path(MESH:"Neurodegenerative Diseases") + g(HGNC:OLR1) increases r(HGNC:OLR1) - pmid:24027553 + pubmed:21709374 - act(p(HGNCGENEFAMILY:Calpains)) increases p(HGNC:MAPT, frag("?", "35kD")) + m(HGNC:MIR369) association r(HGNC:OLR1) - pmid:24027553 + pubmed:21709374 - act(p(HGNCGENEFAMILY:Calpains)) increases p(HGNC:MAPT, frag("?", "17kD")) + r(HGNC:OLR1) association m(HGNC:MIR369) - pmid:24027553 + pubmed:21709374 - act(p(HGNCGENEFAMILY:Calpains)) increases p(HGNC:MAPT, frag("?", "17kD")) + r(HGNC:OLR1) increases p(HGNC:OLR1) - pmid:24027553 + pubmed:18191876 - act(p(HGNCGENEFAMILY:Calpains)) association path(HBP:Excitotoxicity) + g(HGNC:A2M) causesNoChange path(MESH:"Alzheimer Disease") - pmid:24027553 + pubmed:18191876 - act(p(HGNCGENEFAMILY:Calpains)) increases path(HBP:Neurodegeneration) + g(DBSNP:rs12316150) association path(MESH:"Alzheimer Disease") - pmid:30985105 + pubmed:19660836 - p(HGNCGENEFAMILY:Calpains) increases p(HGNC:SNCA, frag("?")) + g(DBSNP:rs4135263) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:30985105 + pubmed:19660836 - act(p(HGNCGENEFAMILY:Calpains)) increases p(HGNC:SNCA, frag("?")) + g(DBSNP:rs4135263) association g(HGNC:PPARG) - pmid:30985105 + pubmed:19660836 - p(HGNCGENEFAMILY:Calpains) increases p(HBP:"alpha-synuclein fibrils", frag("?")) + g(DBSNP:rs1151999) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:30985105 + pubmed:19660836 - act(p(HGNCGENEFAMILY:Calpains)) association path(MESH:"Parkinson Disease") + g(DBSNP:rs1151999) association g(HGNC:PPARG) - pmid:30985105 + pubmed:19660836 - act(p(HGNCGENEFAMILY:Calpains)) association path(MESH:"Parkinson Disease") + g(DBSNP:rs709149) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:30985105 + pubmed:19660836 - p(HGNCGENEFAMILY:Calpains) causesNoChange deg(p(HGNC:SNCA, pmod(HBP:"O-GlcNAcylation", Thr, 72))) + g(DBSNP:rs709149) association g(HGNC:PPARG) - pmid:30985105 + pubmed:19660836 - p(HGNCGENEFAMILY:Calpains) causesNoChange deg(p(HGNC:SNCA, pmod(HBP:"O-GlcNAcylation", Ser, 87))) + g(DBSNP:rs709154) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:30985105 + pubmed:19660836 - p(HGNCGENEFAMILY:Calpains) increases deg(p(HGNC:SNCA)) + g(DBSNP:rs709154) association g(HGNC:PPARG) - pmid:24027553 + pubmed:19660836 - p(HGNC:NPEPPS) increases act(p(HGNCGENEFAMILY:Aminopeptidases)) + g(HGNC:PPARG) association path(MESH:"Alzheimer Disease") - pmid:24027553 + pubmed:19660836 - p(HGNC:NPEPPS) association path(MESH:Tauopathies) + g(HGNC:PPARG) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:24027553 + pubmed:19660836 - p(HGNC:NPEPPS) decreases path(MESH:Tauopathies) + g(HGNC:PPARG) increases r(HGNC:PPARG) - pmid:24027553 + pubmed:19660836 - p(HGNC:NPEPPS) positiveCorrelation p(MGI:Mapt, var("p.P301L")) + g(HGNC:PPARG) association g(DBSNP:rs4135263) - pmid:24027553 + pubmed:19660836 - p(HGNC:NPEPPS) decreases p(MGI:Mapt, var("p.P301L")) + g(HGNC:PPARG) association g(DBSNP:rs1151999) - pmid:24027553 + pubmed:19660836 - p(HGNC:NPEPPS) positiveCorrelation path(MESH:"Frontotemporal Dementia") + g(HGNC:PPARG) association g(DBSNP:rs709149) - pmid:24027553 + pubmed:19660836 - p(HGNC:NPEPPS) decreases p(HGNC:MAPT) + g(HGNC:PPARG) association g(DBSNP:rs709154) - pmid:24027553 + pubmed:21548758 - p(HGNC:NPEPPS) regulates deg(p(HGNC:MAPT)) + m(HGNC:MIR590) association g(HGNC:HNRNPA1) - pmid:24027553 + pubmed:21548758 - p(HGNC:NPEPPS) increases deg(p(HGNC:MAPT)) + g(HGNC:HNRNPA1) association m(HGNC:MIR590) - pmid:24027553 + pubmed:21548758 - p(HGNC:NPEPPS) decreases path(MESH:Paralysis) + g(HGNC:HNRNPA1) association g(DBSNP:rs7967622) - pmid:24027553 + pubmed:21548758 - p(HGNC:NPEPPS) decreases path(MESH:Gliosis) + g(HGNC:HNRNPA1) association path(MESH:"Alzheimer Disease") - pmid:24027553 + pubmed:21548758 - p(HGNC:NPEPPS) increases p(HGNC:MAPT, frag("1_?")) + g(DBSNP:rs7967622) association g(HGNC:HNRNPA1) - pmid:24027553 + pubmed:24162737 - p(HGNC:NPEPPS) increases p(HGNC:MAPT, frag("?_*")) + g(DBSNP:rs10792832) association g(HGNC:PICALM) - pmid:24027553 + pubmed:24162737 - p(HGNC:NPEPPS) increases bp(GO:autophagy) + g(DBSNP:rs6733839) association g(HGNC:BIN1) - pmid:24027553 + pubmed:24162737 - p(HGNC:NPEPPS) increases bp(GO:"autophagosome assembly") + g(DBSNP:rs10948363) association g(HGNC:CD2AP) - pmid:24027553 + pubmed:24162737 - p(HGNC:MAPT, var("p.P301L")) association path(MESH:"Frontotemporal Dementia") + g(DBSNP:rs11218343) association g(HGNC:SORL1) - pmid:24027553 + pubmed:23565137 - p(MGI:Mapt, var("p.P301L")) increases path(HBP:Neurodegeneration) + g(DBSNP:rs11218343) association g(HGNC:SORL1) - pmid:24027553 + pubmed:24162737 - p(MGI:Mapt, var("p.P301L")) positiveCorrelation p(HGNC:NPEPPS) + g(DBSNP:rs4147929) association g(HGNC:ABCA7) - pmid:24027553 + pubmed:24162737 - p(HGNC:PIN1) association path(MESH:"Alzheimer Disease") + g(DBSNP:rs72807343) association g(HGNC:SQSTM1) - pmid:23157676 + pubmed:24162737 - act(p(HGNC:PIN1)) decreases path(MESH:"Alzheimer Disease") + g(HGNC:SQSTM1) association g(DBSNP:rs72807343) - pmid:24027553 + pubmed:24162737 - p(HGNC:PIN1) decreases deg(p(HGNC:MAPT, var("p.P301L"))) + g(HGNC:SQSTM1) association path(MESH:"Alzheimer Disease") - pmid:26751493 + pubmed:24162737 - p(HGNC:PIN1) association p(HBP:"projection domain") + g(DBSNP:rs9331896) association g(HGNC:CLU) - - - - - pmid:25899010 + pubmed:22832961 - p(HGNC:PIN1) decreases path(HBP:Excitotoxicity) + g(DBSNP:rs17817600) association g(HGNC:PICALM) - pmid:25899010 + pubmed:22005930 - p(HGNC:PIN1) decreases path(HBP:Neurodegeneration) + g(DBSNP:rs10792830) association g(HGNC:PICALM) - - - pmid:24964035 + pubmed:22005930 - p(HGNC:PIN1) regulates deg(p(HGNC:SMAD2)) + g(DBSNP:rs10207628) association g(HGNC:BIN1) - pmid:24964035 + pubmed:21627779 - p(HGNC:PIN1) increases complex(p(HGNC:MAPT, pmod(Ph)), p(HGNC:SMAD2)) + g(DBSNP:rs157580) association g(HGNC:TOMM40) - pmid:23157676 + pubmed:21123754 - act(p(HGNC:PIN1)) decreases p(HBP:"cis p-tau") + g(DBSNP:rs157580) association g(HGNC:TOMM40) - pmid:26996941 + pubmed:19125160 - act(p(HGNC:PIN1)) association p(HGNC:MAPT, pmod(Ph, Ser, 235)) + g(DBSNP:rs157580) association g(HGNC:TOMM40) - - - - - - - - - pmid:19401603 + pubmed:21460841 - p(HGNC:PIN1) increases act(p(HGNC:PPP2CA)) + g(DBSNP:rs561655) association g(HGNC:PICALM) - pmid:24027553 + pubmed:21460841 - deg(p(HGNC:MAPT, frag("561_685"))) increases a(HBP:"Tau aggregates") + g(DBSNP:rs3752246) association g(HGNC:ABCA7) - pmid:24027553 + pubmed:23556446 - p(HGNC:MAPT, frag("561_685")) positiveCorrelation a(HBP:"Tau aggregates") + g(DBSNP:rs3752246) association path(MESH:"Alzheimer Disease") - pmid:24027553 + pubmed:21390209 - p(HBP:"cis p-tau") decreases deg(p(HBP:"cis p-tau")) + g(DBSNP:rs3934834) association g(HGNC:AGRN) - pmid:24027553 + pubmed:21390209 - p(HBP:"cis p-tau") decreases act(p(HGNC:PIN1)) + g(HGNC:AGRN) association g(DBSNP:rs3934834) - pmid:23157676 + pubmed:21390209 - p(HBP:"cis p-tau") positiveCorrelation path(MESH:"Alzheimer Disease") + g(HGNC:AGRN) association path(MESH:"Alzheimer Disease") - pmid:23157676 + pubmed:21123754 - p(HBP:"cis p-tau") increases a(HBP:"Tau aggregates") + g(DBSNP:rs2121433) association g(HGNC:EPC2) - pmid:28528849 + pubmed:21123754 - a(HBP:"Tau fibrils") causesNoChange a(MESH:"Dendritic Spines") + g(DBSNP:rs439401) association g(HGNC:APOE) - pmid:30108137 + pubmed:19734902 - a(HBP:"Tau fibrils", loc(GO:lysosome)) increases deg(p(MGI:Tfeb)) + g(DBSNP:rs10052694) association g(HGNC:MIR146A) - pmid:29988016 + pubmed:19734902 - a(HBP:"Tau fibrils") increases a(HBP:"Tau aggregates") + g(HGNC:MIR146A) association g(DBSNP:rs10052694) - pmid:29686391 + pubmed:19734902 - a(HBP:"Tau fibrils") causesNoChange tloc(a(HBP:"Tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + g(HGNC:MIR146A) association path(MESH:"Alzheimer Disease") - pmid:28420982 + pubmed:24586483 - a(HBP:"Tau fibrils") increases a(GO:"neurofibrillary tangle") + g(HGNC:MIR146A) association path(MESH:"Alzheimer Disease") - pmid:24869773 + pubmed:19734902 - a(HBP:"Tau fibrils") association p(HGNC:MAPT) + g(HGNC:MIR146A) association g(DBSNP:rs4921144) - pmid:23088643 + pubmed:19734902 - a(HBP:"Tau fibrils") association p(HGNC:TTBK1) + g(HGNC:MIR146A) association g(DBSNP:rs9313850) - pmid:23088643 + pubmed:24586483 - a(HBP:"Tau fibrils") increases a(HBP:pretangles) + g(HGNC:MIR146A) decreases bp(GO:cognition) - pmid:24027553 + pubmed:19734902 - p(HGNC:MAPT, frag("?", "17kD")) increases path(HBP:"neurite retraction") + g(DBSNP:rs12090333) association g(HGNC:CSF3R) - pmid:24027553 + pubmed:19734902 - p(HGNC:MAPT, frag("?", "17kD")) causesNoChange path(HBP:neurotoxicity) + g(HGNC:CSF3R) association g(DBSNP:rs12090333) - pmid:24027553 + pubmed:19734902 - a(CHEBI:"calpain inhibitor") decreases p(HGNC:MAPT, frag("?", "17kD")) + g(HGNC:CSF3R) association path(MESH:"Alzheimer Disease") - pmid:24027553 + pubmed:19734902 - a(CHEBI:"calpain inhibitor") decreases p(HGNC:MAPT, frag("?", "35kD")) + g(DBSNP:rs12099529) association g(HGNC:NAV3) - pmid:24027553 + pubmed:19734902 - a(CHEBI:"calpain inhibitor") decreases p(HGNC:MAPT, frag("?", "24kD")) + g(HGNC:NAV3) association g(DBSNP:rs12099529) - pmid:24027553 + pubmed:19734902 - a(CHEBI:"calpain inhibitor") decreases act(p(HGNCGENEFAMILY:Calpains)) + g(HGNC:NAV3) association g(DBSNP:rs1795977) - pmid:24027553 + pubmed:19734902 - p(HGNC:MAPT, var("p.D421*")) isA p(HBP:"Tau C3") + g(HGNC:NAV3) association g(DBSNP:rs2710922) - pmid:24027553 + pubmed:19734902 - p(HBP:"Tau C3") increases bp(GO:"apoptotic process") + g(HGNC:NAV3) association path(MESH:"Alzheimer Disease") - pmid:24027553 + pubmed:19734902 - p(HBP:"Tau C3") increases a(HBP:"Tau aggregates") + g(DBSNP:rs17234657) association g(HGNC:DAB2) - pmid:24027553 + pubmed:19734902 - p(HBP:"Tau C3") increases a(HBP:"Tau aggregates") + g(HGNC:DAB2) association g(DBSNP:rs17234657) - pmid:24027553 + pubmed:19734902 - p(HBP:"Tau C3") negativeCorrelation bp(GO:cognition) + g(HGNC:DAB2) association path(MESH:"Alzheimer Disease") - pmid:24027553 + pubmed:19734902 - p(HBP:"Tau C3") association path(MESH:"Neurofibrillary Tangles") + g(HGNC:DAB1) association path(MESH:"Alzheimer Disease") - pmid:25374103 + pubmed:19734902 - p(HBP:"Tau C3") causesNoChange bp(GO:"cell death") + g(HGNC:DAB1) association g(DBSNP:rs11206955) - pmid:25374103 + pubmed:19734902 - p(HBP:"Tau C3") increases act(p(HGNC:CASP3)) + g(HGNC:DAB1) association g(DBSNP:rs11810899) - pmid:25374103 + pubmed:19734902 - p(HBP:"Tau C3") decreases bp(GO:"mitochondrion transport along microtubule") + g(HGNC:DAB1) association g(DBSNP:rs12035887) - pmid:25374103 + pubmed:19734902 - p(HBP:"Tau C3") decreases bp(GO:"mitochondrion transport along microtubule") + g(HGNC:DAB1) association g(DBSNP:rs3754268) - pmid:24027553 + pubmed:19734902 - p(HGNC:MAPT, var("p.D421E")) decreases bp(GO:"apoptotic process") + g(DBSNP:rs1795977) association g(HGNC:NAV3) - - - - - pmid:24027553 + pubmed:19734902 - composite(a(MESH:"Amyloid beta-Peptides"), p(HGNC:CASP3)) increases p(HBP:"Tau C3") + g(DBSNP:rs197196) association g(HGNC:BTBD3) - pmid:24027553 + pubmed:19734902 - a(MESH:"9-deoxy-delta-9-prostaglandin D2") increases act(p(HGNCGENEFAMILY:Caspases)) + g(HGNC:BTBD3) association g(DBSNP:rs197196) - - - - - pmid:24027553 + pubmed:19734902 - act(a(MESH:"Proteasome Endopeptidase Complex")) increases deg(p(HGNC:MAPT)) + g(HGNC:BTBD3) association path(MESH:"Alzheimer Disease") - pmid:24027553 + pubmed:19734902 - a(CHEBI:"N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal") increases p(HGNC:MAPT) + g(DBSNP:rs2264802) association g(HGNC:SKAP2) - pmid:24027553 + pubmed:19734902 - a(CHEBI:"N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal") decreases act(a(CHEBI:"Hsp90 inhibitor")) + g(HGNC:SKAP2) association g(DBSNP:rs2264802) - pmid:24027553 + pubmed:19734902 - act(a(CHEBI:"Hsp90 inhibitor")) decreases p(HGNC:MAPT) + g(HGNC:SKAP2) association g(DBSNP:rs2462910) - pmid:21882945 + pubmed:19734902 - a(CHEBI:"Hsp90 inhibitor") increases deg(p(HGNC:MAPT)) + g(HGNC:SKAP2) association g(DBSNP:rs2465271) - pmid:21882945 + pubmed:19734902 - a(CHEBI:"Hsp90 inhibitor") increases complex(a(MESH:Proteins), p(FPLX:HSP90)) + g(HGNC:SKAP2) association path(MESH:"Alzheimer Disease") - pmid:24027553 + pubmed:19734902 - bp(GO:"vacuolar acidification") increases bp(GO:proteolysis) + g(DBSNP:rs2462910) association g(HGNC:SKAP2) - pmid:24027553 + pubmed:19734902 - bp(GO:"vacuolar acidification") increases bp(GO:autophagy) + g(DBSNP:rs2465271) association g(HGNC:SKAP2) - pmid:24027553 + pubmed:19734902 - bp(GO:"vacuolar acidification") decreases a(MESH:Autophagosomes) + g(DBSNP:rs2710922) association g(HGNC:NAV3) - - - - - pmid:24027553 + pubmed:19734902 - composite(p(HGNC:CTSD), p(HGNC:MAPT)) decreases p(HGNC:MAPT) + g(DBSNP:rs4921144) association g(HGNC:MIR146A) - pmid:24027553 + pubmed:19734902 - composite(p(HGNC:CTSD), p(HGNC:MAPT)) increases p(HGNC:MAPT, frag("?")) + g(DBSNP:rs527384) association g(HGNC:MKI67) - pmid:24027553 + pubmed:19734902 - a(MESH:"3-methyladenine") decreases bp(GO:"autophagosome assembly") + g(HGNC:MKI67) association g(DBSNP:rs527384) - pmid:24027553 + pubmed:19734902 - a(MESH:"3-methyladenine") increases p(HGNC:MAPT) + g(HGNC:MKI67) association path(MESH:"Alzheimer Disease") - pmid:24027553 + pubmed:19734902 - bp(MESH:Autophagy) increases deg(p(HGNC:MAPT)) + g(HGNC:MKI67) association g(DBSNP:rs540879) - pmid:24027553 + pubmed:19734902 - bp(MESH:Autophagy) causesNoChange p(HGNC:MAPT) + g(HGNC:MKI67) association g(DBSNP:rs541392) - pmid:24027553 + pubmed:19734902 - bp(MESH:Autophagy) increases deg(p(HGNC:MAPT, pmod(Ph))) + g(DBSNP:rs540879) association g(HGNC:MKI67) - pmid:24027553 + pubmed:19734902 - bp(MESH:Autophagy) increases deg(p(HGNC:MAPT, pmod(Ph))) + g(DBSNP:rs541392) association g(HGNC:MKI67) - pmid:24027553 + pubmed:19734902 - bp(MESH:Autophagy) decreases p(HGNC:MAPT, var("p.P301L")) + g(DBSNP:rs639446) association g(HGNC:ANXA1) - pmid:24027553 + pubmed:19734902 - bp(MESH:Autophagy) decreases a(HBP:"Tau aggregates") + g(HGNC:ANXA1) association g(DBSNP:rs639446) - pmid:24027553 + pubmed:19734902 - bp(MESH:Autophagy) increases deg(a(HBP:"Tau aggregates")) + g(HGNC:ANXA1) association path(MESH:"Alzheimer Disease") - pmid:24027553 + pubmed:19734902 - bp(MESH:Autophagy) increases deg(a(HBP:"Tau aggregates")) + g(DBSNP:rs7023075) association g(HGNC:SPTLC1) - pmid:24027553 + pubmed:19734902 - bp(MESH:Autophagy) increases deg(a(HBP:"Tau aggregates")) + g(HGNC:SPTLC1) association g(DBSNP:rs7023075) - pmid:24027553 + pubmed:19734902 - bp(MESH:Autophagy) decreases p(MGI:Mapt, var("p.P301S")) + g(HGNC:SPTLC1) association path(MESH:"Alzheimer Disease") - pmid:24027553 + pubmed:19734902 - bp(MESH:Autophagy) decreases p(MGI:Mapt, pmod(Ph, Thr, 212), var("p.P301S")) + g(DBSNP:rs7467550) association g(HGNC:GRIN3A) - pmid:24027553 + pubmed:19734902 - bp(MESH:Autophagy) decreases p(MGI:Mapt, pmod(Ph, Ser, 214), var("p.P301S")) + g(HGNC:GRIN3A) association g(DBSNP:rs7467550) - pmid:24027553 + pubmed:19734902 - bp(MESH:Autophagy) negativeCorrelation bp(GO:"neuron death") + g(HGNC:GRIN3A) association path(MESH:"Alzheimer Disease") - pmid:24027553 + pubmed:19734902 - bp(MESH:Autophagy) increases deg(p(HBP:"Tau C3")) + g(HGNC:GRIN3A) association g(DBSNP:rs843287) - pmid:24027553 + pubmed:19734902 - bp(MESH:Autophagy) decreases p(HBP:"Tau C3") + g(HGNC:GRIN3A) association g(DBSNP:rs860935) - pmid:24027553 + pubmed:19734902 - bp(MESH:Autophagy) decreases p(HBP:"Tau epitope, AT8") + g(DBSNP:rs7668921) association g(HGNC:STIM2) - pmid:24027553 + pubmed:19734902 - bp(MESH:Autophagy) decreases p(HBP:"Tau epitope, PHF1") + g(HGNC:STIM2) association g(DBSNP:rs7668921) - pmid:24027553 + pubmed:19734902 - bp(MESH:Autophagy) decreases p(HBP:"Tau epitope, 12E8") + g(HGNC:STIM2) association path(MESH:"Alzheimer Disease") - pmid:24027553 + pubmed:19734902 - bp(MESH:Autophagy) increases deg(a(HBP:"Tau oligomers")) + g(DBSNP:rs843287) association g(HGNC:GRIN3A) - pmid:24027553 + pubmed:19734902 - a(MESH:Trehalose) increases bp(MESH:Autophagy) + g(DBSNP:rs860935) association g(HGNC:GRIN3A) - pmid:24027553 + pubmed:19734902 - a(MESH:Trehalose) increases bp(MESH:Autophagy) + g(DBSNP:rs9313850) association g(HGNC:MIR146A) - pmid:24027553 + pubmed:19734902 - a(MESH:Trehalose) increases bp(MESH:Autophagy) + g(DBSNP:rs9404493) association g(HGNC:GRIK2) - pmid:24027553 + pubmed:19734902 - a(MESH:Trehalose) decreases a(HBP:"Tau aggregates") + g(HGNC:GRIK2) association g(DBSNP:rs9404493) - pmid:24027553 + pubmed:19734902 - a(MESH:Trehalose) decreases p(HGNC:MAPT) + g(HGNC:GRIK2) association path(MESH:"Alzheimer Disease") - - - - - pmid:24027553 + pubmed:19734902 - composite(a(MESH:Ubiquitin), p(HGNC:MAPT)) increases p(HGNC:MAPT, pmod(Ub)) + g(DBSNP:rs10084692) association g(HGNC:ROBO2) - + + + pubmed:19734902 + + g(HGNC:ROBO2) association g(DBSNP:rs10084692) + - + + + pubmed:19734902 + + g(HGNC:ROBO2) association path(MESH:"Alzheimer Disease") + - + + + pubmed:19734902 + + g(HGNC:ROBO2) association g(DBSNP:rs9309766) + - pmid:16176937 + pubmed:19734902 - p(RGD:Mapt) isA complex(p(RGD:Klc1), p(RGD:Mapt)) + g(HGNC:ROBO2) association g(DBSNP:rs9818075) - pmid:16176937 + pubmed:19734902 - p(RGD:Mapt) isA complex(p(RGD:Klc2), p(RGD:Mapt)) + g(DBSNP:rs10925500) association g(HGNC:RYR2) - pmid:20133804 + pubmed:19734902 - act(p(RGD:Mapt)) increases bp(GO:"microtubule polymerization") + g(HGNC:RYR2) association g(DBSNP:rs10925500) - pmid:20133804 + pubmed:19734902 - act(p(RGD:Mapt)) increases bp(GO:"neuron projection development") + g(HGNC:RYR2) association path(MESH:"Alzheimer Disease") - + + + pubmed:19734902 + + g(DBSNP:rs11206955) association g(HGNC:DAB1) + - + + + pubmed:19734902 + + g(DBSNP:rs11810899) association g(HGNC:DAB1) + - + + + pubmed:19734902 + + g(DBSNP:rs12035887) association g(HGNC:DAB1) + - + + + pubmed:19734902 + + g(DBSNP:rs1217338) association g(HGNC:APBA1) + - + + + pubmed:19734902 + + g(HGNC:APBA1) association g(DBSNP:rs1217338) + - pmid:28784767 + pubmed:19734902 - p(HBP:"Tau epitope, AT8") equivalentTo p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205), pmod(Ph, Thr, 208)) + g(HGNC:APBA1) association g(DBSNP:rs7866199) - pmid:28784767 + pubmed:19734902 - p(HBP:"Tau epitope, AT8") increases a(HBP:"Tau aggregates") + g(HGNC:APBA1) association path(MESH:"Alzheimer Disease") - pmid:21734277 + pubmed:19734902 - p(HBP:"Tau epitope, AT8") decreases bp(GO:"anterograde axonal protein transport") + g(DBSNP:rs12212067) association g(HGNC:FOXO3) - pmid:21734277 + pubmed:19734902 - p(HBP:"Tau epitope, AT8") causesNoChange bp(GO:"retrograde axonal protein transport") + g(HGNC:FOXO3) association g(DBSNP:rs12212067) - - - pmid:21734277 + pubmed:19734902 - p(HBP:"Tau epitope, AT8") causesNoChange p(HBP:"phosphatase-activating domain") + g(HGNC:FOXO3) association path(MESH:"Alzheimer Disease") - pmid:23088643 + pubmed:19734902 - p(HBP:"Tau epitope, AT8") association a(GO:"neurofibrillary tangle") + g(DBSNP:rs17105095) association g(HGNC:SLC25A21) - pmid:23088643 + pubmed:19734902 - p(HBP:"Tau epitope, AT8") association a(MESH:"Neuropil Threads") + g(HGNC:SLC25A21) association g(DBSNP:rs17105095) - pmid:23088643 + pubmed:19734902 - p(HBP:"Tau epitope, AT8") association path(MESH:"Plaque, Amyloid") + g(HGNC:SLC25A21) association path(MESH:"Alzheimer Disease") - pmid:28784767 + pubmed:19734902 - p(HBP:"Tau epitope, AT8") increases p(HBP:"Tau aggregates") + g(HGNC:SLC25A21) association g(DBSNP:rs17105125) - pmid:27087442 + pubmed:19734902 - p(HBP:"Tau epitope, AT8") positiveCorrelation p(HBP:"CDK5R1 p25") + g(HGNC:SLC25A21) association g(DBSNP:rs17105164) - pmid:22253473 + pubmed:19734902 - p(HBP:"Tau epitope, AT8") positiveCorrelation a(MESH:Neuropil) + g(DBSNP:rs17105125) association g(HGNC:SLC25A21) - pmid:20869593 + pubmed:19734902 - p(HBP:"Tau epitope, AT8") positiveCorrelation p(HGNC:MAPT, pmod(Ac)) + g(DBSNP:rs17105164) association g(HGNC:SLC25A21) - pmid:20869593 + pubmed:19734902 - p(HBP:"Tau epitope, AT8") negativeCorrelation act(p(HGNC:SIRT1)) + g(DBSNP:rs2596163) association g(HGNC:RYR3) - pmid:22156579 + pubmed:19734902 - p(HBP:"Tau epitope, PHF1") positiveCorrelation p(HBP:"Tau epitope, 12E8") + g(HGNC:RYR3) association g(DBSNP:rs2596163) - pmid:22156579 + pubmed:19734902 - p(HBP:"Tau epitope, PHF1") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) + g(HGNC:RYR3) association g(DBSNP:rs2676087) - pmid:22156579 + pubmed:19734902 - p(HBP:"Tau epitope, PHF1") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 404)) + g(HGNC:RYR3) association g(DBSNP:rs8026464) - pmid:24033439 + pubmed:19734902 - p(HBP:"Tau epitope, PHF1") biomarkerFor path(MESH:"Alzheimer Disease") + g(HGNC:RYR3) association path(MESH:"Alzheimer Disease") - pmid:24033439 + pubmed:19734902 - p(HBP:"Tau epitope, PHF1") increases p(HBP:"Tau aggregates") + g(DBSNP:rs2676087) association g(HGNC:RYR3) - - - pmid:22156579 + pubmed:19734902 - p(HBP:"Tau epitope, 12E8") positiveCorrelation p(HBP:"Tau epitope, PHF1") + g(DBSNP:rs362769) association g(HGNC:RELN) - pmid:25031639 + pubmed:19734902 - p(HBP:"Tau epitope, 12E8") partOf p(HBP:"KXGS motif") + g(HGNC:RELN) association g(DBSNP:rs362769) - pmid:27574109 + pubmed:19734902 - a(HBP:"4R tau") positiveCorrelation path(MESH:"Protein Aggregation, Pathological") + g(HGNC:RELN) association path(MESH:"Alzheimer Disease") - pmid:27574109 + pubmed:20452100 - a(HBP:"4R tau") positiveCorrelation path(MESH:"Protein Aggregation, Pathological") + g(HGNC:RELN) association g(DBSNP:rs4298437) - pmid:27574109 + pubmed:19734902 - a(HBP:"4R tau") positiveCorrelation bp(GO:"positive regulation of protein oligomerization") + g(DBSNP:rs3754268) association g(HGNC:DAB1) - pmid:27574109 + pubmed:19734902 - a(HBP:"4R tau") positiveCorrelation path(MESH:"Alzheimer Disease") + g(DBSNP:rs540787) association g(HGNC:GRIK4) - pmid:27574109 + pubmed:19734902 - a(HBP:"4R tau") positiveCorrelation path(MESH:"Pick Disease of the Brain") + g(HGNC:GRIK4) association g(DBSNP:rs540787) - pmid:27574109 + pubmed:19734902 - a(HBP:"4R tau") positiveCorrelation a(HBP:"Corticobasal Degeneration") + g(HGNC:GRIK4) association path(MESH:"Alzheimer Disease") - pmid:27574109 + pubmed:19734902 - a(HBP:"Tau isoform F (441 aa)") positiveCorrelation path(MESH:"Protein Aggregation, Pathological") + g(DBSNP:rs754107) association g(HGNC:BIN1) - pmid:27574109 + pubmed:19734902 - a(HBP:"Tau isoform F (441 aa)") increases a(HBP:"Tau oligomers") + g(DBSNP:rs7866199) association g(HGNC:APBA1) - pmid:27574109 + pubmed:19734902 - a(HBP:"Tau isoform F (441 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain") + g(DBSNP:rs8026464) association g(HGNC:RYR3) - pmid:29686391 + pubmed:19734902 - a(HBP:"Tau isoform F (441 aa)") positiveCorrelation tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + g(DBSNP:rs8064630) association g(HGNC:ATP2A3) - pmid:29686391 + pubmed:19734902 - tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) positiveCorrelation a(HBP:"Tau isoform F (441 aa)") + g(HGNC:ATP2A3) association g(DBSNP:rs8064630) - pmid:29686391 + pubmed:19734902 - a(HBP:"Tau isoform F (441 aa)") increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + g(HGNC:ATP2A3) association path(MESH:"Alzheimer Disease") - pmid:29686391 + pubmed:19734902 - tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) association a(CHEBI:heparin) + g(DBSNP:rs9309766) association g(HGNC:ROBO2) - pmid:29686391 + pubmed:19734902 - tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) association a(HBP:"6-O-sulfated heparin") + g(DBSNP:rs9818075) association g(HGNC:ROBO2) - pmid:27574109 + pubmed:23571587 - bp(GO:"positive regulation of protein oligomerization") positiveCorrelation a(HBP:"4R tau") + g(DBSNP:rs115550680) association g(HGNC:ABCA7) - pmid:27574109 + pubmed:23565137 - bp(GO:"positive regulation of protein oligomerization") positiveCorrelation a(HBP:"3R tau") + g(DBSNP:rs519113) association g(HGNC:NECTIN2) - pmid:27574109 + pubmed:23565137 - a(HBP:"Tau isoform Fetal-tau (352 aa)") association a(HBP:"phosphatase-activating domain") + g(HGNC:NECTIN2) association g(DBSNP:rs519113) - pmid:27574109 + pubmed:23419831 - a(HBP:"Tau isoform Fetal-tau (352 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain") + g(HGNC:NECTIN2) association g(DBSNP:rs6857) - pmid:27574109 + pubmed:22005931 - a(HBP:"Tau isoform Fetal-tau (352 aa)") increases a(HBP:"Tau oligomers") + g(HGNC:NECTIN2) association g(DBSNP:rs6857) - pmid:27574109 + pubmed:22159054 - a(HBP:"Tau isoform Fetal-tau (352 aa)") increases a(HBP:"Tau oligomers") + g(HGNC:NECTIN2) association g(DBSNP:rs6859) - pmid:27574109 + pubmed:18823527 - a(HBP:"phosphatase-activating domain") association a(HBP:"Tau isoform Fetal-tau (352 aa)") + g(HGNC:NECTIN2) association g(DBSNP:rs6859) - pmid:27574109 + pubmed:20885792 - a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Tau isoform Fetal-tau (352 aa)") + g(HGNC:NECTIN2) association g(DBSNP:rs6859) - pmid:27574109 + pubmed:23562540 - a(HBP:"phosphatase-activating domain") association a(HBP:"Tau isoform D (383 aa)") + g(DBSNP:rs769449) association g(HGNC:APOE) - pmid:27574109 + pubmed:23535033 - a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Tau isoform D (383 aa)") + g(DBSNP:rs77636885) association g(HGNC:CAMK4) - pmid:27574109 + pubmed:23535033 - a(HBP:"phosphatase-activating domain") association a(HBP:"Tau isoform C (410 aa)") + g(HGNC:CAMK4) association g(DBSNP:rs77636885) - pmid:27574109 + pubmed:23535033 - a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Tau isoform C (410 aa)") + g(HGNC:CAMK4) association path(MESH:"Alzheimer Disease") - pmid:27574109 + pubmed:23535033 - a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) + g(DBSNP:rs1861525) association g(HGNC:CYCS) - pmid:27574109 + pubmed:23535033 - a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) + g(HGNC:CYCS) association g(DBSNP:rs1861525) - pmid:27574109 + pubmed:23535033 - a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) + g(HGNC:CYCS) association path(MESH:"Alzheimer Disease") - pmid:27574109 + pubmed:23419831 - a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) + g(DBSNP:rs59007384) association g(HGNC:TOMM40) - pmid:27574109 + pubmed:23419831 - a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) + g(DBSNP:rs6857) association g(HGNC:NECTIN2) - pmid:27574109 + pubmed:22005931 - a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) + g(DBSNP:rs6857) association g(HGNC:NECTIN2) - pmid:27574109 + pubmed:22430674 - a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) + g(DBSNP:rs17314229) association g(HGNC:FRMD4A) - pmid:27574109 + pubmed:22430674 - a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) + g(HGNC:FRMD4A) association g(DBSNP:rs17314229) - pmid:27574109 + pubmed:22430674 - a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) + g(HGNC:FRMD4A) association g(DBSNP:rs2446581) - pmid:27574109 + pubmed:22430674 - a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) + g(HGNC:FRMD4A) association g(DBSNP:rs7081208) - pmid:27574109 + pubmed:22430674 - a(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) + g(DBSNP:rs2446581) association g(HGNC:FRMD4A) - pmid:27574109 + pubmed:22430674 - a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Tau isoform B (381 aa)") + g(DBSNP:rs7081208) association g(HGNC:FRMD4A) - pmid:27574109 + pubmed:19136949 - a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Tau isoform F (441 aa)") + g(DBSNP:rs2573905) association g(HGNC:PCDH11X) - pmid:27574109 + pubmed:19734903 - a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Tau isoform E (412 aa)") + g(DBSNP:rs2279590) association g(HGNC:CLU) - pmid:27574109 + pubmed:20452100 - a(HBP:"phosphatase-activating domain") association a(HBP:pretangles) + g(DBSNP:rs4298437) association g(HGNC:RELN) - pmid:27574109 + pubmed:22107728 - a(HBP:"phosphatase-activating domain") association a(HBP:"Braak_Stage I") + g(DBSNP:rs4646953) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:27574109 + pubmed:22107728 - a(HBP:"phosphatase-activating domain") association a(HBP:"Braak_Stage II") + g(DBSNP:rs4646953) positiveCorrelation p(HGNC:APP, frag("672_713")) - pmid:27574109 + pubmed:22107728 - a(HBP:"phosphatase-activating domain") association a(MESH:"Neurofibrillary Tangles") + g(DBSNP:rs2251101) association path(MESH:"Diabetes Mellitus, Type 2") - pmid:27574109 + pubmed:22107728 - a(HBP:"phosphatase-activating domain") association a(HBP:"Corticobasal Degeneration") + g(DBSNP:rs1887922) causesNoChange path(MESH:"Alzheimer Disease") - pmid:27574109 + pubmed:22107728 - a(HBP:"phosphatase-activating domain") positiveCorrelation a(HBP:"Corticobasal Degeneration") + g(DBSNP:rs1887922) causesNoChange path(MESH:"Diabetes Mellitus, Type 2") - pmid:27574109 + pubmed:23279143 - a(HBP:"phosphatase-activating domain") association a(GO:"Pick body") + p(HGNC:SORCS1) association path(MESH:"Alzheimer Disease") - pmid:27574109 + pubmed:23279143 - a(HBP:"phosphatase-activating domain") positiveCorrelation path(MESH:Tauopathies) + p(HGNC:SORCS1) association path(MESH:"Diabetes Mellitus, Type 2") - pmid:27574109 + pubmed:25570489 - a(HBP:"phosphatase-activating domain") positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:SORCS1) association a(NIFT:"Ventricular expansion") - pmid:27574109 + pubmed:23279143 - a(HBP:"phosphatase-activating domain") positiveCorrelation path(MESH:"Pick Disease of the Brain") + r(HGNC:SORCS1) decreases p(HGNC:APP, frag("672_713")) - pmid:27574109 + pubmed:23279143 - a(HBP:"Tau isoform D (383 aa)") association a(HBP:"phosphatase-activating domain") + g(HGNC:SORCS1) association g(DBSNP:rs7907690) - pmid:27574109 + pubmed:23279143 - a(HBP:"Tau isoform D (383 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain") + g(DBSNP:rs7907690) association g(HGNC:SORCS1) - pmid:27574109 + pubmed:23279143 - a(HBP:"Tau isoform D (383 aa)") increases a(HBP:"Tau oligomers") + g(DBSNP:rs7907690) association path(MESH:"Alzheimer Disease") - pmid:27574109 + pubmed:23279143 - a(HBP:"Tau isoform D (383 aa)") increases a(HBP:"Tau oligomers") + g(DBSNP:rs7907690) association path(MESH:"Alzheimer Disease") - pmid:27574109 + pubmed:23279143 - a(HBP:"Tau isoform C (410 aa)") association a(HBP:"phosphatase-activating domain") + g(DBSNP:rs7907690) association path(MESH:"Diabetes Mellitus, Type 2") - pmid:27574109 + pubmed:23279143 - a(HBP:"Tau isoform C (410 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain") + g(DBSNP:rs601883) association path(MESH:"Alzheimer Disease") - pmid:27574109 + pubmed:23279143 - a(HBP:"Tau isoform C (410 aa)") increases a(HBP:"Tau oligomers") + g(DBSNP:rs17277986) association path(MESH:"Alzheimer Disease") - pmid:27574109 + pubmed:23279143 - a(HBP:"Tau isoform C (410 aa)") increases a(HBP:"Tau oligomers") + g(DBSNP:rs2900717) association path(MESH:"Alzheimer Disease") - pmid:27574109 + pubmed:23279143 - p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") + g(DBSNP:rs10884399) association path(MESH:"Alzheimer Disease") - pmid:27574109 + pubmed:23279143 - p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") + g(DBSNP:rs11193170) association path(MESH:"Alzheimer Disease") - pmid:27574109 + pubmed:23279143 - p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") + g(DBSNP:rs4918280) association path(MESH:"Alzheimer Disease") - pmid:27574109 + pubmed:23279143 - p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") + g(DBSNP:rs600879) association path(MESH:"Alzheimer Disease") - pmid:27574109 + pubmed:23403532 - p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") + complex(p(HGNC:NRXN2), p(INTERPRO:Neuroligin)) increases bp(GO:"synapse assembly") - pmid:27574109 + pubmed:23403532 - p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") + complex(p(HGNC:NRXN2), p(INTERPRO:Neuroligin)) association path(MESH:"Alzheimer Disease") + + + + + + + + - pmid:27574109 + pubmed:23403532 - p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") + complex(p(HGNC:NRXN3), p(INTERPRO:Neuroligin)) increases bp(GO:"synapse assembly") - pmid:27574109 + pubmed:23403532 - p(HBP:"Tau isoform D (383 aa)", pmod(HBP:"protein aggregation")) causesNoChange bp(GO:"retrograde axonal transport") + complex(p(HGNC:NRXN3), p(INTERPRO:Neuroligin)) association path(MESH:"Alzheimer Disease") + + - pmid:27574109 + pubmed:23403532 - p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") + complex(p(HGNC:NRXN1), p(INTERPRO:Neuroligin)) increases bp(GO:"synapse assembly") - pmid:27574109 + pubmed:23403532 - p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") + complex(p(HGNC:NRXN1), p(INTERPRO:Neuroligin)) association path(MESH:"Alzheimer Disease") + + - pmid:27574109 + pubmed:23403532 - p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") + g(HGNC:NRXN3) association g(DBSNP:rs17757879) - pmid:27574109 + pubmed:23403532 - p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") + g(DBSNP:rs17757879) association g(HGNC:NRXN3) - pmid:27574109 + pubmed:23403532 - p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") + g(DBSNP:rs17757879) decreases path(MESH:"Alzheimer Disease") - pmid:27574109 + pubmed:21036197 - p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") + g(DBSNP:rs411280) association g(HGNC:NTM) - pmid:27574109 + pubmed:21036197 - p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") + g(DBSNP:rs411280) association path(MESH:"Alzheimer Disease") - pmid:27574109 + pubmed:21036197 - p(HBP:"Tau isoform C (410 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"retrograde axonal transport") + g(HGNC:NTM) association g(DBSNP:rs411280) - pmid:27574109 + pubmed:21036197 - p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") + g(DBSNP:rs3846329) association g(HGNC:NR3C2) - pmid:27574109 + pubmed:21036197 - p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") + g(HGNC:NR3C2) association g(DBSNP:rs3846329) - pmid:27574109 + pubmed:21036197 - p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") + g(HGNC:NR3C2) association bp(GO:cognition) - pmid:27574109 + pubmed:24586483 - p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") + bp(GO:"amyloid precursor protein metabolic process") association m(HGNC:MIR146A) - pmid:27574109 + pubmed:25038421 - p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") + g(DBSNP:rs998382) association g(HGNC:DNMT3B) - pmid:27574109 + pubmed:25038421 - p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") + g(DBSNP:rs998382) association path(MESH:"Alzheimer Disease") - pmid:27574109 + pubmed:25038421 - p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:"protein aggregation")) causesNoChange bp(GO:"retrograde axonal transport") + g(HGNC:DNMT3B) association g(DBSNP:rs998382) - - - pmid:29191965 + pubmed:25038421 - p(HBP:"Tau isoform Fetal-tau (352 aa)") decreases bp(GO:locomotion) + g(HGNC:DNMT3B) association g(DBSNP:rs2424913) + + - pmid:17493042 + pubmed:25038421 - p(HBP:"Tau isoform Fetal-tau (352 aa)") partOf a(MESH:Brain) + g(DBSNP:rs2424913) association g(HGNC:DNMT3B) - pmid:27574109 + pubmed:25038421 - p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") + g(DBSNP:rs2424913) association path(MESH:"Alzheimer Disease") - pmid:27574109 + pubmed:22272627 - p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") + g(DBSNP:rs2424913) increases path(EFO:"late-onset Alzheimers disease") - pmid:27574109 + pubmed:22272627 - p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") + g(HGNC:DNMT3B, var("c.149C>T")) increases path(EFO:"late-onset Alzheimers disease") - pmid:27574109 + pubmed:22272627 - p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") + g(HGNC:DNMT3B, var("c.79G>T")) increases path(EFO:"late-onset Alzheimers disease") - pmid:27574109 + pubmed:22272627 - p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") + g(DBSNP:rs1569686) increases path(EFO:"late-onset Alzheimers disease") - pmid:27574109 + pubmed:22691691 - p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") + g(DBSNP:rs1569686) increases g(HGNC:DRD4, gmod(go:0006306 ! "DNA methylation")) + + - pmid:27574109 + pubmed:22691691 - p(HBP:"Tau isoform B (381 aa)", pmod(HBP:"protein aggregation")) causesNoChange bp(GO:"retrograde axonal transport") + g(HGNC:DRD4) increases p(HGNC:DRD4) - pmid:27574109 + pubmed:22691691 - p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") + g(DBSNP:rs752306) increases g(HGNC:DRD4, gmod(go:0006306 ! "DNA methylation")) - pmid:27574109 + pubmed:22691691 - p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") + g(DBSNP:rs11246228) increases g(HGNC:DRD4, gmod(go:0006306 ! "DNA methylation")) - pmid:27574109 + pubmed:22691691 - p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") + g(DBSNP:rs936465) increases g(HGNC:DRD4, gmod(go:0006306 ! "DNA methylation")) - pmid:27574109 + pubmed:22691691 - p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") + p(HGNC:DRD4) association g(DBSNP:rs3758653) - pmid:27574109 + pubmed:22691691 - p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") + p(HGNC:DRD4) association path(MESH:"Alzheimer Disease") - pmid:27574109 + pubmed:22691691 - p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") + g(DBSNP:rs3758653) association p(HGNC:DRD4) - pmid:27574109 + pubmed:25800888 - p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"protein aggregation")) causesNoChange bp(GO:"retrograde axonal transport") + g(DBSNP:rs17070145) association p(HGNC:WWC1) - pmid:27574109 + pubmed:27004735 - p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) positiveCorrelation a(HBP:"phosphatase-activating domain") + p(HGNC:TOMM40) association g(DBSNP:rs2075650) - pmid:27574109 + pubmed:25862420 - p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") + p(HGNC:TOMM40) decreases a(NIFT:"Cortical Thickness") - pmid:27574109 + pubmed:22550605 - p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") + p(HGNC:TOMM40) increases tloc(p(HGNC:APP, frag("672_713")), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + - pmid:27574109 + pubmed:" 26517285" - p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) increases a(HBP:"Tau oligomers") + bp(GO:"lipid transport") association g(HGNC:CLU) - pmid:27574109 + pubmed:" 26517285" - p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") + bp(GO:"lipid transport") association g(HGNC:ABCA7) - pmid:27574109 + pubmed:" 26517285" - p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") + bp(GO:"lipid metabolic process") association g(HGNC:SORL1) - pmid:27574109 + pubmed:" 26517285" - p(HBP:"Tau isoform E (412 aa)", pmod(HBP:"protein aggregation")) causesNoChange bp(GO:"retrograde axonal transport") + bp(GO:"lipid metabolic process") association g(HGNC:PICALM) - pmid:27574109 + pubmed:19293145 - a(HBP:"Tau isoform B (381 aa)") increases a(HBP:"Tau oligomers") + bp(GO:"lipid metabolic process") association p(HGNC:APOE) - pmid:27574109 + pubmed:19293145 - a(HBP:"Tau isoform B (381 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain") + bp(GO:"lipid metabolic process") association p(HGNC:CHRNA4) - pmid:27574109 + pubmed:22142809 - a(HBP:"Tau isoform E (412 aa)") increases a(HBP:"Tau oligomers") + bp(GO:"lipid metabolic process") association p(HGNC:CAV2) - pmid:27574109 + pubmed:" 26517285" - a(HBP:"Tau isoform E (412 aa)") positiveCorrelation a(HBP:"phosphatase-activating domain") + g(HGNC:TREM2) increases path(MESH:"Alzheimer Disease") - pmid:27574109 + pubmed:" 26517285" - a(HBP:pretangles) association a(HBP:"Tau oligomers") + g(DBSNP:rs3824968) association g(HGNC:CLU) - pmid:27574109 + pubmed:" 26517285" - a(HBP:pretangles) association a(HBP:"phosphatase-activating domain") + g(DBSNP:rs3824968) increases g(HGNC:CLU) - pmid:27574109 + pubmed:" 26517285" - a(HBP:pretangles) association p(HGNC:MAPT) + g(DBSNP:rs3824968) association bp(GO:"microglial cell activation") - pmid:23407988 + pubmed:" 26517285" - a(HBP:pretangles) increases complex(GO:"dendritic tree") + g(DBSNP:rs3824968) association bp(GO:"complement activation") - pmid:23088643 + pubmed:26996954 - a(HBP:pretangles) association p(HGNC:TTBK1) + g(DBSNP:rs3824968) association p(HGNC:SORL1) - pmid:23088643 + pubmed:26996954 - a(HBP:pretangles) association p(HGNC:MAPT, pmod(Ph, Ser, 422)) + g(DBSNP:rs3824968) association g(HGNC:SORL1) - pmid:23088643 + pubmed:26996954 - a(HBP:pretangles) isA a(GO:"neurofibrillary tangle") + g(DBSNP:rs3824968) association g(HGNC:SORL1) - pmid:27574109 + pubmed:26996954 - a(HBP:"Braak_Stage I") association a(HBP:"Tau oligomers") + g(DBSNP:rs3824968) negativeCorrelation a(NIFT:"Grey matter volume") - pmid:27574109 + pubmed:26996954 - a(HBP:"Braak_Stage I") association a(HBP:"phosphatase-activating domain") + g(DBSNP:rs3824968) association path(MESH:"Amyloid Neuropathies") - pmid:27574109 + pubmed:26996954 - a(HBP:"Braak_Stage I") association p(HGNC:MAPT) + g(DBSNP:rs3824968) association a(NIFT:"Brain volume") - pmid:28176663 + pubmed:26996954 - a(HBP:"Braak_Stage I") positiveCorrelation act(p(HGNC:GSK3B), ma(kin)) + g(DBSNP:rs3824968) association a(NIFT:"White Matter Hyperintensity") - pmid:27574109 + pubmed:26996954 - a(HBP:"Corticobasal Degeneration") association a(HBP:"Tau oligomers") + g(DBSNP:rs3824968) increases act(a(CHEBI:amyloid-beta)) - pmid:27574109 + pubmed:26996954 - a(HBP:"Corticobasal Degeneration") positiveCorrelation a(HBP:"Tau oligomers") + g(DBSNP:rs3824968) association path(MESH:"Cerebrovascular Disorders") - pmid:27574109 + pubmed:22950410 - a(HBP:"Corticobasal Degeneration") positiveCorrelation a(HBP:"Tau oligomers") + g(DBSNP:rs1800547) increases g(HGNC:LRRC37A4P) - pmid:27574109 + pubmed:22950410 - a(HBP:"Corticobasal Degeneration") association a(HBP:"phosphatase-activating domain") + g(DBSNP:rs1800547) increases p(HGNC:MAPT) - pmid:27574109 + pubmed:22950410 - a(HBP:"Corticobasal Degeneration") positiveCorrelation a(HBP:"phosphatase-activating domain") + g(DBSNP:rs1800547) decreases g(HGNC:ARF2P) - pmid:27574109 + pubmed:22950410 - a(HBP:"Corticobasal Degeneration") association p(HGNC:MAPT) + g(DBSNP:rs1800547) decreases p(HGNC:LRRC37A) - pmid:27574109 + pubmed:22950410 - a(HBP:"Corticobasal Degeneration") positiveCorrelation p(HGNC:MAPT) + g(DBSNP:rs1800547) decreases p(HGNC:CRHR1) - pmid:27574109 + pubmed:22950410 - a(HBP:"Corticobasal Degeneration") positiveCorrelation p(HGNC:MAPT) + g(DBSNP:rs1800547) increases p(HGNC:CRHR1) - pmid:27574109 + pubmed:22950410 - a(HBP:"Corticobasal Degeneration") positiveCorrelation a(HBP:"4R tau") + p(HGNC:CRHR1) association path(MESH:Depression) - pmid:27574109 + pubmed:22950410 - a(HBP:"Corticobasal Degeneration") positiveCorrelation composite(a(HBP:"phosphatase-activating domain"), p(HGNC:MAPT)) + p(HGNC:CRHR1) increases path(MESH:Depression) - - - - - pmid:27574109 + pubmed:22950410 - composite(a(HBP:"phosphatase-activating domain"), p(HGNC:MAPT)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:CRHR1) association path(MESH:Anxiety) - pmid:27574109 + pubmed:22950410 - composite(a(HBP:"phosphatase-activating domain"), p(HGNC:MAPT)) positiveCorrelation path(MESH:"Pick Disease of the Brain") + p(HGNC:CRHR1) increases path(MESH:Anxiety) - pmid:27574109 + pubmed:22950410 - composite(a(HBP:"phosphatase-activating domain"), p(HGNC:MAPT)) positiveCorrelation a(HBP:"Corticobasal Degeneration") + p(HGNC:CRHR1) association path(MESH:Alcoholism) - pmid:17403556 + pubmed:22950410 - a(HBP:"amyloid-beta derived diffusible ligands") decreases bp(MESH:"Cell Survival") + p(HGNC:CRHR1) increases path(MESH:Alcoholism) - pmid:17403556 + pubmed:22950410 - a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:CRHR1) association path(MESH:"Multiple Sclerosis") - pmid:17403556 + pubmed:25687773 - a(HBP:"amyloid-beta derived diffusible ligands") increases p(RGD:Mapt, pmod(Ph)) + p(HGNC:CRHR1) association g(DBSNP:rs393152) - pmid:17403556 + pubmed:25687773 - a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) + p(HGNC:CRHR1) association g(DBSNP:rs393152) - pmid:17403556 + pubmed:22950410 - a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) + path(MESH:Alcoholism) association p(HGNC:CRHR1) - pmid:17403556 + pubmed:26979166 - a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) + path(MESH:Alcoholism) positiveCorrelation path(MESH:Depression) - pmid:17403556 + pubmed:26979166 - a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) + path(MESH:Alcoholism) positiveCorrelation path(DOID:"bipolar disorder") - pmid:17403556 + pubmed:21482353 - a(HBP:"amyloid-beta derived diffusible ligands") increases complex(a(GO:synapse), a(HBP:"amyloid-beta derived diffusible ligands")) + path(MESH:Alcoholism) positiveCorrelation p(HGNC:CHRNA5, var("?")) - pmid:17403556 + pubmed:21482353 - a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + path(MESH:Alcoholism) positiveCorrelation p(HGNC:CHRNA3, var("?")) - pmid:17403556 + pubmed:21482353 - a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + path(MESH:Alcoholism) positiveCorrelation p(HGNC:CHRNB4, var("?")) - pmid:17403556 + pubmed:25687773 - a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + g(DBSNP:rs393152) association p(HGNC:CRHR1) - pmid:17403556 + pubmed:25687773 - a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + g(DBSNP:rs393152) association p(HGNC:CRHR1) - pmid:17403556 + pubmed:25687773 - a(HBP:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) + g(DBSNP:rs393152) association path(MESH:Atrophy) - pmid:26195256 + pubmed:25687773 - deg(a(HBP:"amyloid-beta derived diffusible ligands")) decreases a(HBP:"amyloid-beta derived diffusible ligands") + g(DBSNP:rs393152) positiveCorrelation path(MESH:Atrophy) - pmid:26195256 + pubmed:25687773 - tloc(a(HBP:"amyloid-beta derived diffusible ligands"), fromLoc(GO:"extracellular region"), toLoc(MESH:"Intracellular Space")) decreases a(HBP:"amyloid-beta derived diffusible ligands") + g(DBSNP:rs393152) association path(MESH:"Alzheimer Disease") - pmid:26195256 + pubmed:25687773 - tloc(a(HBP:"amyloid-beta derived diffusible ligands"), fromLoc(MESH:Brain), toLoc(MESH:Blood)) decreases a(HBP:"amyloid-beta derived diffusible ligands") + g(DBSNP:rs393152) association path(MESH:"Alzheimer Disease") - pmid:26195256 + pubmed:25687773 - tloc(a(HBP:"amyloid-beta derived diffusible ligands"), fromLoc(MESH:Blood), toLoc(MESH:"Cerebrospinal Fluid")) decreases a(HBP:"amyloid-beta derived diffusible ligands") + g(DBSNP:rs393152) increases p(HGNC:MAPT) - pmid:26195256 + pubmed:25687773 - tloc(a(HBP:"amyloid-beta derived diffusible ligands"), fromLoc(MESH:Brain), toLoc(MESH:"Extracellular Fluid")) decreases a(HBP:"amyloid-beta derived diffusible ligands") + g(DBSNP:rs393152) association bp(GO:"neurofibrillary tangle assembly") - pmid:26195256 + pubmed:19419557 - tloc(a(HBP:"amyloid-beta derived diffusible ligands"), fromLoc(MESH:"Cerebrospinal Fluid"), toLoc(MESH:"Cardiovascular System")) decreases a(HBP:"amyloid-beta derived diffusible ligands") + p(HGNC:CALB1) increases bp(GO:"calcium ion transport") + + - pmid:26195256 + pubmed:25514383 - tloc(a(HBP:"amyloid-beta derived diffusible ligands"), fromLoc(MESH:"Cerebrospinal Fluid"), toLoc(MESH:"Lymphatic System")) decreases a(HBP:"amyloid-beta derived diffusible ligands") + bp(GO:"calcium ion transport") negativeCorrelation p(CONSO:"alpha-4 beta-2 nAChR") - pmid:18096814 + pubmed:25514383 - a(HBP:"amyloid-beta derived diffusible ligands") increases tloc(p(MGI:Fyn), fromLoc(GO:cytoplasm), toLoc(GO:"membrane raft")) + bp(GO:"calcium ion transport") positiveCorrelation a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") - pmid:18096814 + pubmed:21482353 - a(HBP:"amyloid-beta derived diffusible ligands") increases tloc(p(MGI:Mapt), fromLoc(GO:cytoplasm), toLoc(GO:"membrane raft")) + bp(GO:"calcium ion transport") association act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) - pmid:30985105 + pubmed:19419557 - p(RGD:Mapt, pmod(Ph)) negativeCorrelation p(RGD:Mapt, pmod(HBP:"O-GlcNAcylation")) + p(FPLX:"CAMK2_family") increases bp(GO:"calcium ion transport") - pmid:20133804 + pubmed:2833519 - p(RGD:Mapt, pmod(Ph)) positiveCorrelation p(RGD:Fkbp4) + act(p(FPLX:"CAMK2_family")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:29421605 + pubmed:19419557 - p(RGD:Mapt, pmod(Ph)) positiveCorrelation bp(GO:aging) + p(HGNC:PVALB) increases bp(GO:"calcium ion transport") - - - - - pmid:17403556 + pubmed:19419557 - a(HBP:"amyloid-beta antibody, NU1") decreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + a(CHEBI:"glutamate(2-)") association bp(GO:"synaptic transmission, glutamatergic") - pmid:17403556 + pubmed:19419557 - a(HBP:"amyloid-beta antibody, NU1") decreases p(HGNC:MAPT, pmod(Ph, Thr, 231)) + a(CHEBI:"glutamate(2-)") association p(MESH:"Receptors, Ionotropic Glutamate") - pmid:17403556 + pubmed:19419557 - a(HBP:"amyloid-beta antibody, NU1") decreases p(HGNC:MAPT, pmod(Ph, Thr, 231)) + a(CHEBI:"glutamate(2-)") association p(HGNCGENEFAMILY:"Glutamate metabotropic receptors") - pmid:17403556 + pubmed:19126755 - a(HBP:"amyloid-beta antibody, NU1") decreases complex(a(HBP:"amyloid-beta derived diffusible ligands"), a(MESH:Neurons)) + a(CHEBI:"glutamate(2-)", loc(MESH:"Dopaminergic Neurons")) increases bp(GO:"synaptic transmission, dopaminergic") - pmid:17403556 + pubmed:19293145 - a(HBP:"amyloid-beta antibody, NU1") decreases complex(a(HBP:"amyloid-beta derived diffusible ligands"), a(MESH:Neurons)) + act(a(CHEBI:"glutamate(2-)")) increases path(CONSO:Excitotoxicity) - pmid:17403556 + pubmed:22530628 - a(HBP:"amyloid-beta antibody, NU1") decreases complex(a(GO:synapse), a(HBP:"amyloid-beta derived diffusible ligands")) + act(a(CHEBI:"glutamate(2-)")) increases path(CONSO:Excitotoxicity) - pmid:28420982 + pubmed:17009926 - p(HGNC:MAPT, pmod(Ph, Thr, 181)) association a(MESH:Exosomes) + tloc(a(CHEBI:"glutamate(2-)"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) increases bp(GO:"long-term synaptic potentiation") - pmid:28420982 + pubmed:16273023 - p(HGNC:MAPT, pmod(Ph, Thr, 181)) positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:"glutamate(2-)") directlyIncreases bp(GO:"GO:0014047") - pmid:28420982 + pubmed:16273023 - p(HGNC:MAPT, pmod(Ph, Thr, 181)) positiveCorrelation path(MESH:"Frontotemporal Dementia") + a(CHEBI:"glutamate(2-)") directlyIncreases act(p(MESH:D017470)) - pmid:17078951 + pubmed:30697142 - p(HGNC:MAPT, pmod(Ph, Thr, 181)) positiveCorrelation p(FPLX:PKA) + a(CHEBI:"glutamate(2-)") regulates bp(GO:"learning or memory") - pmid:11943212 + pubmed:30697142 - p(HGNC:MAPT, pmod(Ph, Thr, 181)) partOf p(HBP:"Tau epitope, AT270") + a(CHEBI:"glutamate(2-)") increases bp(MESH:"Neuronal Plasticity") - pmid:17403556 + pubmed:19419557 - a(MESH:"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine") decreases p(HGNC:MAPT, pmod(Ph, Thr, 231)) + p(MESH:"Receptors, Ionotropic Glutamate") association a(CHEBI:"glutamate(2-)") - pmid:17403556 + pubmed:19419557 - a(MESH:"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine") decreases bp(GO:"signal transduction") + p(MESH:"Receptors, Ionotropic Glutamate") increases path(CONSO:Excitotoxicity) - pmid:17403556 + pubmed:19419557 - a(MESH:"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine") decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + p(MESH:"Receptors, Ionotropic Glutamate") increases tloc(a(MESH:Calcium), fromLoc(MESH:"Cell Membrane"), toLoc(GO:intracellular)) - pmid:17403556 + pubmed:19419557 - a(CHEBI:LY294002) decreases p(HGNC:MAPT, pmod(Ph, Thr, 231)) + p(MESH:"Receptors, Ionotropic Glutamate") decreases act(p(MESH:"Calcium Channels")) - pmid:17403556 + pubmed:19419557 - a(CHEBI:LY294002) decreases bp(GO:"signal transduction") + p(MESH:"Receptors, Ionotropic Glutamate") increases bp(GO:"calcium ion import") - pmid:17403556 + pubmed:19419557 - a(CHEBI:LY294002) decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + p(MESH:"Receptors, Ionotropic Glutamate") increases a(CHEBI:"nitric oxide") - - - - - pmid:17403556 + pubmed:19419557 - complex(a(HBP:"amyloid-beta derived diffusible ligands"), p(HGNC:MAPT)) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + p(MESH:"Receptors, Ionotropic Glutamate") increases bp(GO:"regulation of calcium-mediated signaling") - - - - - pmid:27671637 + pubmed:19419557 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) association a(GO:"somatodendritic compartment") + p(HGNCGENEFAMILY:"Glutamate metabotropic receptors") association a(CHEBI:"glutamate(2-)") - pmid:27671637 + pubmed:30837838 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases bp(GO:"protein localization to somatodendritic compartment") + p(HGNCGENEFAMILY:"Glutamate metabotropic receptors") increases act(p(MESH:"Sodium Channels")) - pmid:27671637 + pubmed:30837838 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) association a(HBP:"Tau epitope, 12E8") + p(HGNCGENEFAMILY:"Glutamate metabotropic receptors") increases act(p(MESH:"Calcium Channels")) + + - pmid:27671637 + pubmed:19126755 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) association a(HBP:"Tau epitope, PHF1") + p(HGNCGENEFAMILY:"Glutamate ionotropic receptor kainate type subunits") association a(CHEBI:anandamide) - pmid:27671637 + pubmed:19419557 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) negativeCorrelation a(HBP:"Tau epitope, AT180") + act(p(FPLX:GRIA)) increases a(CHEBI:"nitric oxide") - pmid:27671637 + pubmed:19419557 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) positiveCorrelation a(HBP:"Tau epitope, AT8") + act(p(FPLX:GRIA)) increases bp(GO:"negative regulation of calcium-mediated signaling") - pmid:27671637 + pubmed:19419557 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) causesNoChange a(GO:"neurofibrillary tangle") + a(CONSO:"amyloid-beta oligomers") increases act(p(HGNC:GRIN1)) + + - pmid:27671637 + pubmed:21871088 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) causesNoChange a(GO:"dendritic spine") + a(CONSO:"amyloid-beta oligomers") decreases bp(GO:"long-term synaptic potentiation") - pmid:27671637 + pubmed:21871088 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) decreases a(GO:mitochondrion) + a(CONSO:"amyloid-beta oligomers") increases bp(GO:"long-term synaptic depression") - pmid:27671637 + pubmed:21871088 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) causesNoChange act(a(GO:presynapse)) + a(CONSO:"amyloid-beta oligomers") decreases bp(GO:"synaptic signaling") - pmid:27671637 + pubmed:21871088 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) decreases a(MESH:Axons) + a(CONSO:"amyloid-beta oligomers") increases path(MESH:"Cognitive Dysfunction") - pmid:29202785 + pubmed:19293145 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Hippocampus) + a(CONSO:"amyloid-beta oligomers") positiveCorrelation path(MESH:"Cognitive Dysfunction") - pmid:29202785 + pubmed:19126755 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Hippocampus) + a(CONSO:"amyloid-beta oligomers") regulates act(p(HGNC:CHRNA7)) - pmid:29202785 + pubmed:19293145 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Hippocampus) + a(CONSO:"amyloid-beta oligomers") isA a(CHEBI:amyloid-beta) - pmid:29202785 + pubmed:19293145 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) + a(CONSO:"amyloid-beta oligomers") association path(CONSO:neurotoxicity) - pmid:29202785 + pubmed:19293145 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) + a(CONSO:"amyloid-beta oligomers") directlyIncreases path(CONSO:neurotoxicity) - pmid:29202785 + pubmed:19293145 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) + a(CONSO:"amyloid-beta oligomers") increases act(p(FPLX:JNK)) - pmid:29202785 + pubmed:19293145 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) + a(CONSO:"amyloid-beta oligomers") decreases act(p(FPLX:ERK)) - pmid:29202785 + pubmed:26813123 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) + a(CONSO:"amyloid-beta oligomers") association act(a(GO:"cholinergic synapse")) - pmid:29202785 + pubmed:30145931 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) + a(CONSO:"amyloid-beta oligomers") increases p(HGNC:MAPT, loc(MESH:Dendrites)) - pmid:29202785 + pubmed:24760868 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) + a(CONSO:"amyloid-beta oligomers") increases p(HGNC:MAPT, loc(MESH:"Post-Synaptic Density")) - pmid:29202785 + pubmed:24760868 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases bp(GO:neurogenesis) + a(CONSO:"amyloid-beta oligomers") decreases p(HGNC:MAPT, loc(GO:synapse)) - pmid:29202785 + pubmed:24760868 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) negativeCorrelation act(a(MESH:Microglia)) + a(CONSO:"amyloid-beta oligomers") decreases p(HGNC:MAPT, loc(GO:synapse)) - pmid:29202785 + pubmed:24760868 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) decreases act(a(MESH:Microglia)) + a(CONSO:"amyloid-beta oligomers") increases p(HGNC:MAPT, loc(GO:synapse)) - pmid:29202785 + pubmed:23528736 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) causesNoChange act(a(MESH:Microglia)) + a(CONSO:"amyloid-beta oligomers") increases p(HGNC:MAPT) - pmid:29202785 + pubmed:30145931 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) causesNoChange path(MESH:Inflammation) + a(CONSO:"amyloid-beta oligomers") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262), pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) - pmid:29202785 + pubmed:30145931 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases p(MGI:Mapt) + a(CONSO:"amyloid-beta oligomers") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) - pmid:29202785 + pubmed:17403556 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases p(MGI:Mapt) + a(CONSO:"amyloid-beta oligomers") increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:29202785 + pubmed:17403556 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases tloc(p(MGI:Mapt), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) + a(CONSO:"amyloid-beta oligomers") increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:29202785 + pubmed:24760868 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases p(MGI:Mapt) + a(CONSO:"amyloid-beta oligomers") increases p(HGNC:DLG4) - pmid:29202785 + pubmed:24760868 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:"Stem Cells") + a(CONSO:"amyloid-beta oligomers") decreases p(HGNC:DLG4, loc(GO:synapse)) - pmid:29202785 + pubmed:24760868 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases bp(GO:"neuron differentiation") + a(CONSO:"amyloid-beta oligomers") increases p(HGNC:GRIA1) - pmid:29202785 + pubmed:24760868 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) decreases p(MGI:Wnt5a) + a(CONSO:"amyloid-beta oligomers") increases p(HGNC:FYN) - pmid:29202785 + pubmed:24760868 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases p(MGI:Wnt3) + a(CONSO:"amyloid-beta oligomers") decreases bp(GO:"actin filament polymerization") - pmid:29202785 + pubmed:24760868 - p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases p(MGI:Wnt3) + a(CONSO:"amyloid-beta oligomers") decreases a(MESH:Actins, loc(GO:synapse)) - pmid:27671637 + pubmed:24760868 - a(GO:"somatodendritic compartment") association p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) + a(CONSO:"amyloid-beta oligomers") increases complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) - pmid:27671637 + pubmed:24760868 - a(GO:"somatodendritic compartment") association p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) + a(CONSO:"amyloid-beta oligomers") increases complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) - pmid:27671637 + pubmed:24760868 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) association a(GO:"somatodendritic compartment") + a(CONSO:"amyloid-beta oligomers") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) - pmid:27671637 + pubmed:24760868 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases bp(GO:"protein localization to somatodendritic compartment") + a(CONSO:"amyloid-beta oligomers") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) - pmid:27671637 + pubmed:24760868 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) association a(HP:"Argyrophilic inclusion bodies") + a(CONSO:"amyloid-beta oligomers") regulates p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:27671637 + pubmed:24760868 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation a(HP:"Argyrophilic inclusion bodies") + a(CONSO:"amyloid-beta oligomers") causesNoChange p(HGNC:MAPT, var("p.Ser404Ala"), loc(MESH:"Dendritic Spines")) - pmid:27671637 + pubmed:23528736 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation a(MESH:Axons) + a(CONSO:"amyloid-beta oligomers") decreases act(p(FPLX:Proteasome)) - pmid:27671637 + pubmed:22156579 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(MESH:Axons) + act(a(CONSO:"amyloid-beta oligomers")) positiveCorrelation a(MESH:"Microtubule-Associated Proteins") - pmid:27671637 + pubmed:19419557 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation a(GO:"dendritic spine") + complex(a(CONSO:"amyloid-beta oligomers"), p(HGNC:GRIN1)) association act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) - pmid:27671637 + pubmed:20556492 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(GO:"dendritic spine") + p(HGNC:GRIN2B) increases act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) - pmid:27671637 + pubmed:20556492 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases act(a(GO:dendrite)) + p(HGNC:GRIN2B) increases path(MP:0008235) - - - pmid:27671637 - - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) association a(HBP:"Tau epitope, 12E8") - + - pmid:27671637 + pubmed:19419557 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) association a(HBP:"Tau epitope, PHF1") + bp(GO:"calcium-mediated signaling") association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:27671637 + pubmed:19419557 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation a(HBP:"Tau epitope, AT180") + bp(GO:"calcium-mediated signaling") association a(CHEBI:amyloid-beta) - pmid:27671637 + pubmed:19293145 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation a(HBP:"Tau epitope, AT8") + bp(GO:"calcium-mediated signaling") association act(a(CHEBI:amyloid-beta)) - pmid:27671637 + pubmed:19293145 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation a(GO:"neurofibrillary tangle") + bp(GO:"calcium-mediated signaling") association bp(MESH:Neuroprotection) - pmid:27671637 + pubmed:19293145 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases bp(GO:"mitochondrial transport") + bp(GO:"calcium-mediated signaling") association act(p(HGNC:CHRNA7)) - pmid:27671637 + pubmed:19293145 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(GO:mitochondrion) + bp(GO:"calcium-mediated signaling") association a(CHEBI:nicotine) - pmid:27671637 + pubmed:19293145 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(CHEBI:ATP) + bp(GO:"calcium-mediated signaling") association composite(p(HGNC:JAK2), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:27671637 + pubmed:23746257 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(CHEBI:ATP) + bp(GO:"calcium-mediated signaling") association p(FPLX:HSP90) - pmid:27671637 + pubmed:19419557 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation act(a(MESH:Neurons)) + composite(p(HGNC:CAMK2A), p(HGNC:CAMK2B)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + - pmid:29202785 + pubmed:29428175 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(MESH:Neurons) + p(HGNC:CAMK2B) positiveCorrelation bp(MESH:"Calcium Signaling") - pmid:29202785 + pubmed:29428175 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(MESH:Neurons) + p(HGNC:CAMK2B) association bp(MESH:"Calcium Signaling") - pmid:29202785 + pubmed:29428175 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(MESH:Neurons) + p(HGNC:CAMK2B) regulates p(MESH:"Ion Channels") - pmid:28528849 + pubmed:29428175 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(MESH:Neurons) + p(HGNC:CAMK2B) regulates p(MESH:"Cytoskeletal Proteins") - pmid:27671637 + pubmed:29428175 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation p(MGI:Fos) + p(HGNC:CAMK2B) regulates p(HGNC:CHRNA7) - pmid:27671637 + pubmed:29428175 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation bp(GO:"astrocyte activation") + act(p(HGNC:CAMK2B)) increases bp(GO:"actin rod assembly") - pmid:27671637 + pubmed:29428175 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation p(MGI:Gfap) + act(p(HGNC:CAMK2B)) increases a(MESH:Axons) - pmid:27671637 + pubmed:12428809 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation bp(GO:"response to oxidative stress") + p(HGNC:CAMK2B) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:27671637 + pubmed:21722302 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation p(MGI:Hmox1) + p(HGNC:CAMK2B) increases act(p(HGNC:PRKAA1)) - pmid:27671637 + pubmed:21722302 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases act(a(GO:presynapse)) + p(HGNC:CAMK2B) increases act(complex(GO:"Atg1/ULK1 kinase complex")) - pmid:27671637 + pubmed:27796283 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases bp(GO:"spontaneous synaptic transmission") + p(HGNC:CAMK2B) increases p(CONSO:"Kalirin 7", pmod(go:0006468 ! "protein phosphorylation", Thr, 95)) - pmid:29202785 + pubmed:19419557 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases a(HBP:"Tau aggregates") + p(FPLX:CAPN) increases act(p(HGNC:CDK5), ma(go:0016301 ! "kinase activity")) - pmid:29202785 + pubmed:19419557 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(GO:synapse) + act(p(FPLX:CAPN), ma(go:0008233 ! "peptidase activity")) increases rxn(reactants(p(HGNC:CDK5R1)), products(p(CONSO:"CDK5R1 p25"))) - pmid:28528849 + pubmed:24653673 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(GO:synapse) + p(FPLX:CAPN) increases p(HGNC:IGBP1, frag("?")) - pmid:29202785 + pubmed:22908190 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases path(HBP:Neurodegeneration) + p(FPLX:CAPN) increases deg(p(HGNC:MAPT)) - pmid:29202785 + pubmed:29626319 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation act(a(MESH:Microglia)) + p(FPLX:CAPN) increases deg(p(HGNC:MAPT)) - pmid:29202785 + pubmed:29626319 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases a(MESH:Microglia) + p(FPLX:CAPN) increases p(HGNC:MAPT, frag("?")) - pmid:29202785 + pubmed:26118667 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases act(a(MESH:Microglia)) + act(p(FPLX:CAPN)) positiveCorrelation rxn(reactants(p(RGD:Cdk5r1)), products(p(CONSO:"CDK5R1 p25"))) - pmid:29202785 + pubmed:26118667 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases path(MESH:Inflammation) + act(p(FPLX:CAPN)) increases deg(p(HGNC:NFKBIA)) - pmid:29202785 + pubmed:26118667 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases path(MESH:Hypertrophy) + act(p(FPLX:CAPN)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + - pmid:29202785 + pubmed:19419557 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases tloc(p(MGI:Mapt), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) + p(CONSO:"CDK5R1 p25") regulates act(p(HGNC:CDK5), ma(go:0016301 ! "kinase activity")) - pmid:29202785 + pubmed:26118667 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) causesNoChange p(MGI:Mapt) + p(CONSO:"CDK5R1 p25") negativeCorrelation p(HGNC:CDK5R1) - pmid:29202785 + pubmed:26118667 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) causesNoChange p(MGI:Mapt) + p(CONSO:"CDK5R1 p25") equivalentTo p(HGNC:CDK5R1, frag("99_307")) - pmid:29202785 + pubmed:26118667 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases tloc(p(MGI:Mapt), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) + p(CONSO:"CDK5R1 p25") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:29202785 + pubmed:26118667 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) causesNoChange a(MESH:"Stem Cells") + p(CONSO:"CDK5R1 p25") positiveCorrelation a(GO:"neurofibrillary tangle") - pmid:29202785 + pubmed:26118667 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases bp(GO:"neuron differentiation") + p(CONSO:"CDK5R1 p25") regulates p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:29202785 + pubmed:27087442 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(MESH:Hippocampus) + p(CONSO:"CDK5R1 p25") positiveCorrelation p(CONSO:"Tau epitope, AT8") - pmid:28528849 + pubmed:14642273 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases bp(GO:memory) + p(CONSO:"CDK5R1 p25") directlyIncreases act(p(MGI:Cdk5), ma(go:0016301 ! "kinase activity")) - pmid:28528849 + pubmed:19419557 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases a(HBP:"Tau fibrils") + complex(p(HGNC:ITPR1), p(HGNC:PSEN1)) increases bp(GO:"regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity") + + + + - pmid:28528849 + pubmed:20556492 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases a(HBP:"Tau oligomers") + act(p(HGNC:ITPR1)) increases a(CHEBI:"1D-myo-inositol 1,4,5-trisphosphate") - pmid:28528849 + pubmed:19419557 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases p(HBP:"Tau oligomers", var("p.Lys280del")) + bp(GO:"regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity") association complex(p(HGNC:ATP2A3), p(HGNC:PSEN1)) - pmid:28528849 + pubmed:19419557 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) causesNoChange a(CHEBI:"reactive oxygen species") + bp(GO:"regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity") increases p(HGNC:APP, frag("672_713")) - pmid:28528849 + pubmed:29428175 - p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) causesNoChange a(CHEBI:"calcium(2+)", loc(GO:intracellular)) + bp(GO:"regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity") increases bp(MESH:"Calcium Signaling") - pmid:27671637 + pubmed:29428175 - a(HP:"Argyrophilic inclusion bodies") association p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) + bp(GO:"regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity") association a(MESH:Phospholipids) - pmid:27671637 + pubmed:29428175 - a(HP:"Argyrophilic inclusion bodies") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) + bp(GO:"regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity") increases act(p(HGNC:CAMK2B, loc(MESH:Synapses))) - pmid:27671637 + pubmed:29428175 - a(HP:"Argyrophilic inclusion bodies") causesNoChange p(MGI:Syp) + bp(GO:"regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity") regulates bp(GO:"calcium ion homeostasis") - pmid:27671637 + pubmed:19419557 - p(MGI:Mapt, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356)) decreases complex(a(GO:microtubule), p(MGI:Mapt)) + complex(p(HGNC:PSEN1), p(HGNC:RYR1), p(HGNC:RYR2), p(HGNC:RYR3)) increases bp(GO:"regulation of ryanodine-sensitive calcium-release channel activity") @@ -133615,1610 +135480,1592 @@

Statements

+ + - pmid:27671637 + pubmed:19419557 - a(HBP:"Tau epitope, 12E8") association p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) + bp(GO:"regulation of ryanodine-sensitive calcium-release channel activity") increases p(HGNC:APP, frag("672_713")) - pmid:27671637 + pubmed:19419557 - a(HBP:"Tau epitope, 12E8") association p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) + complex(p(HGNC:ATP2A3), p(HGNC:PSEN1)) association bp(GO:"sequestering of calcium ion") - pmid:27671637 + pubmed:19419557 - a(HBP:"Tau epitope, PHF1") association p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) + complex(p(HGNC:ATP2A3), p(HGNC:PSEN1)) association bp(GO:"regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity") + + - pmid:27671637 + pubmed:19419557 - a(HBP:"Tau epitope, PHF1") association p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) + bp(GO:"sequestering of calcium ion") association complex(p(HGNC:ATP2A3), p(HGNC:PSEN1)) - pmid:27671637 + pubmed:26968346 - a(HBP:"Tau epitope, AT180") negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) + bp(GO:"sequestering of calcium ion") positiveCorrelation p(HGNC:PSEN1) - pmid:27671637 + pubmed:26968346 - a(HBP:"Tau epitope, AT180") negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) + bp(GO:"sequestering of calcium ion") positiveCorrelation p(HGNC:PSEN2) - pmid:27671637 + pubmed:19419557 - a(HBP:"Tau epitope, AT8") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) + p(HGNC:CALHM1) association bp(GO:"calcium ion import") - pmid:27671637 + pubmed:19419557 - a(HBP:"Tau epitope, AT8") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) + p(HGNC:CALHM1) increases act(p(FPLX:ERK)) - - - pmid:27671637 + pubmed:25999473 - composite(a(HP:"Argyrophilic inclusion bodies"), p(MGI:Mapt)) negativeCorrelation bp(GO:"cellular protein catabolic process") + p(HGNC:CALHM1) increases tloc(p(HGNC:IDE), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:27671637 + pubmed:18585350 - p(MGI:Fos) negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) + p(HGNC:CALHM1) increases path(MESH:"Alzheimer Disease") - pmid:27671637 + pubmed:19419557 - p(MGI:Fos) biomarkerFor act(a(MESH:Neurons)) + p(HGNC:CALHM1, var("p.Pro86Leu")) association path(MESH:"Alzheimer Disease") - pmid:27671637 + pubmed:19419557 - p(MGI:Gfap) negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) + p(HGNC:CALHM1, var("p.Pro86Leu")) increases a(CHEBI:amyloid-beta) + + - pmid:27671637 + pubmed:19419557 - p(MGI:Gfap) biomarkerFor bp(GO:"astrocyte activation") + g(DBSNP:rs2986017) increases p(HGNC:CALHM1, var("p.Pro86Leu")) - pmid:27671637 + pubmed:19419557 - p(MGI:Hmox1) negativeCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) + g(DBSNP:rs2986017) increases a(CHEBI:amyloid-beta) - pmid:27671637 + pubmed:18585350 - p(MGI:Hmox1) biomarkerFor bp(GO:"response to oxidative stress") + g(DBSNP:rs2986017) increases bp(GO:"neuron death") - pmid:27671637 + pubmed:18585350 - a(CHEBI:adenosine) increases act(p(MGI:Adora1)) + g(DBSNP:rs2986017) increases a(NIFT:"Hippocampal atrophy") - pmid:27671637 + pubmed:18585350 - a(CHEBI:adenosine) decreases act(a(MESH:Neurons)) + g(DBSNP:rs2986017) increases p(HGNC:APP) - pmid:27671637 + pubmed:18585350 - a(CHEBI:adenosine) decreases act(a(GO:presynapse)) + g(DBSNP:rs2986017) increases bp(GO:"calcium ion homeostasis") - pmid:27671637 + pubmed:21657833 - a(CHEBI:adenosine) decreases bp(GO:"long-term synaptic potentiation") + a(CHEBI:decursinol) association p(HGNC:ABCB4) - pmid:21882945 + pubmed:21657833 - a(CHEBI:adenosine) decreases act(p(INTERPRO:"Heat shock protein 70 family")) + a(CHEBI:decursinol) association p(HGNC:ABCC2) - pmid:27671637 + pubmed:21657833 - act(p(MGI:Adora1)) decreases act(a(MESH:Neurons)) + p(HGNC:ABCB4) association a(CHEBI:decursinol) - pmid:27671637 + pubmed:21657833 - act(p(MGI:Adora1)) decreases act(a(GO:presynapse)) + p(HGNC:ABCC2) association a(CHEBI:decursinol) + + - pmid:27671637 + pubmed:23556446 - act(p(MGI:Adora1)) decreases bp(GO:"long-term synaptic potentiation") + p(HGNC:ABCC2) association p(HGNC:ABCC2, var("p.Cys3972Thr")) - pmid:27671637 + pubmed:23556446 - a(PUBCHEM:64627) decreases act(p(MGI:Adora1)) + p(HGNC:ABCC2) association path(MESH:"Alzheimer Disease") - pmid:27671637 + pubmed:23556446 - a(PUBCHEM:64627) increases act(a(MESH:Neurons)) + p(HGNCGENEFAMILY:"ATP binding cassette subfamily A") association path(MESH:"Alzheimer Disease") - pmid:27671637 + pubmed:23556446 - a(PUBCHEM:64627) increases act(a(GO:presynapse)) + g(DBSNP:rs3740066) association path(MESH:"Alzheimer Disease") - pmid:27671637 + pubmed:23556446 - a(PUBCHEM:64627) increases a(GO:"dendritic spine") + p(HGNC:ABCC2, var("p.Cys3972Thr")) association p(HGNC:ABCC2) - pmid:27671637 + pubmed:23556446 - a(PUBCHEM:64627) decreases a(MESH:Axons) + p(HGNC:ABCC2, var("p.Cys3972Thr")) association path(MESH:"Alzheimer Disease") - pmid:27671637 + pubmed:23556446 - a(MESH:"BSc 3094") decreases a(HBP:"Tau aggregates") + p(HGNC:ABCB1) increases a(CHEBI:amyloid-beta) - pmid:27671637 + pubmed:26195256 - a(MESH:"BSc 3094") increases act(a(GO:presynapse)) + p(HGNC:ABCB1) increases tloc(a(CHEBI:amyloid-beta)) - - - - - pmid:27671637 + pubmed:26195256 - composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases a(GO:"dendritic spine") + p(HGNC:ABCB1) increases tloc(a(CHEBI:amyloid-beta)) - pmid:27671637 + pubmed:26195256 - composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases a(GO:"dendritic spine") + p(HGNC:ABCB1) increases tloc(a(CHEBI:amyloid-beta)) - pmid:27671637 + pubmed:29626319 - composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases act(a(GO:presynapse)) + p(HGNC:ABCB1) increases tloc(a(CHEBI:amyloid-beta), fromLoc(MESH:Brain), toLoc(GO:"extracellular region")) - pmid:27671637 + pubmed:29626319 - composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases act(a(MESH:Neurons)) + p(HGNC:ABCB1) decreases a(CHEBI:amyloid-beta) - pmid:27671637 + pubmed:26195256 - composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases p(MGI:Fos) + p(HGNC:ABCB1) increases act(p(HGNC:APOE)) - pmid:27671637 + pubmed:26195256 - composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases path(MESH:"Spatial Memory") + p(HGNC:ABCB1) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:27671637 + pubmed:24173717 - composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases bp(GO:"long-term memory") + g(DBSNP:rs9807444) increases p(HGNC:TUBB6) - pmid:27671637 + pubmed:24173717 - composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases bp(GO:"associative learning") + p(HGNC:TUBB6) negativeCorrelation bp(GO:"microtubule cytoskeleton organization") - pmid:27671637 + pubmed:24173717 - composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases bp(GO:"excitatory postsynaptic potential") + p(HGNC:TUBB6) negativeCorrelation bp(GO:pyroptosis) - pmid:27671637 + pubmed:24393168 - composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases bp(GO:"spontaneous synaptic transmission") + p(HGNC:TUBB6) association a(CHEBI:crocin-1) - - - - - pmid:27671637 + pubmed:26973255 - composite(a(PUBCHEM:64627), p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del"))) causesNoChange a(GO:"dendritic spine") + p(HGNC:TUBB6) biomarkerFor path(MESH:"Alzheimer Disease") - pmid:28784767 + pubmed:24275654 - p(HGNC:MAPT, pmod(Ph, Ser, 208)) partOf p(HBP:"Tau epitope, AT8") + p(HGNC:TUBB6) association p(HGNC:LRRK2) - pmid:22833681 + pubmed:24173717 - p(HGNC:MAPT, pmod(Ph, Ser, 208)) partOf p(HBP:"Tau epitope, AT8") + a(CHEBI:paclitaxel) decreases p(HGNC:TUBB6) - pmid:28784767 + pubmed:29758300 - p(HGNC:MAPT, pmod(Ph, Ser, 208)) decreases a(HBP:"Tau Protein Secondary Structure, Turn") + a(CHEBI:paclitaxel) increases a(GO:microtubule) - pmid:26751493 + pubmed:30116051 - p(HGNC:MAPT, pmod(Ph, Ser, 208)) positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:paclitaxel) increases a(GO:microtubule) - pmid:22833681 + pubmed:29758300 - p(HGNC:MAPT, pmod(Ph, Ser, 208)) increases complex(p(HGNC:FYN), p(HGNC:MAPT)) + a(CHEBI:paclitaxel) increases tloc(a(GO:autophagosome), fromLoc(GO:"extracellular space"), toLoc(MESH:Neurons)) - pmid:28784767 + pubmed:22941973 - p(HGNC:MAPT, pmod(Ph, Thr, 205)) partOf p(HBP:"Tau epitope, AT8") + a(CHEBI:paclitaxel) decreases p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) - pmid:25331948 + pubmed:22941973 - p(HGNC:MAPT, pmod(Ph, Thr, 205)) partOf p(HBP:"Tau epitope, AT8") + a(CHEBI:paclitaxel) increases p(RGD:Syp) - pmid:22833681 + pubmed:24393168 - p(HGNC:MAPT, pmod(Ph, Thr, 205)) partOf p(HBP:"Tau epitope, AT8") + a(CHEBI:crocin-1) association p(HGNC:TUBB6) - pmid:24760868 + pubmed:26330360 - p(HGNC:MAPT, pmod(Ph, Thr, 205)) increases p(HGNC:MAPT, loc(MESH:"Dendritic Spines")) + g(HGNC:TUBB6) association path(MESH:"Colonic Neoplasms") - pmid:29191965 + pubmed:26330360 - p(HGNC:MAPT, pmod(Ph, Thr, 205)) positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:"Colonic Neoplasms") association g(HGNC:TUBB6) - pmid:22817713 + pubmed:24275654 - p(HGNC:MAPT, pmod(Ph, Thr, 205)) association a(HBP:"Tau aggregates") + p(HGNC:TUBB4A) association p(HGNC:LRRK2) - pmid:22817713 + pubmed:25024322 - p(HGNC:MAPT, pmod(Ph, Thr, 205)) association a(HBP:"Tau oligomers") + a(NIFT:"Free and Cued Selective Reminding Test") positiveCorrelation p(HGNC:CHI3L1) - pmid:22486774 + pubmed:25024322 - p(HGNC:MAPT, pmod(Ph, Thr, 205)) partOf a(HBP:"Tau oligomers") + a(CONSO:"Mini-Mental Status Exam") positiveCorrelation p(HGNC:CHI3L1) - pmid:14612456 + pubmed:25865441 - p(HGNC:MAPT, pmod(Ph, Thr, 205)) isA p(HGNC:MAPT, pmod(Ph)) + a(NIFT:"Cortical Thickness") negativeCorrelation p(HGNC:CHI3L1) - pmid:17078951 + pubmed:25865441 - p(HGNC:MAPT, pmod(Ph, Thr, 205)) positiveCorrelation p(FPLX:PKA) + a(NIFT:"Cortical Thickness") negativeCorrelation p(HGNC:CHI3L1) - pmid:28784767 + pubmed:26836182 - p(HGNC:MAPT, pmod(Ph, Thr, 205)) increases p(HBP:"Tau aggregates") + a(NIFT:"Cortical Thickness") negativeCorrelation p(HGNC:CHI3L1) - pmid:19459590 + pubmed:26027813 - p(HGNC:MAPT, pmod(Ph, Thr, 205)) decreases complex(a(MESH:Microtubules), p(HGNC:MAPT)) + a(NIFT:"Cortical Thickness") association a(CHEBI:amyloid-beta) - pmid:22833681 + pubmed:21504134 - p(HGNC:MAPT, pmod(Ph, Thr, 205)) increases complex(p(HGNC:FYN), p(HGNC:MAPT)) + a(NIFT:"Cortical Thickness") negativeCorrelation p(HGNC:APOE) - pmid:22833681 + pubmed:22711244 - p(HGNC:MAPT, pmod(Ph, Thr, 205)) positiveCorrelation p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) + a(NIFT:"Cortical Thickness") positiveCorrelation p(HGNC:ARHGEF40) - pmid:24406748 + pubmed:25862420 - p(HGNC:MAPT, pmod(Ph, Thr, 205)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Ser")) + g(DBSNP:rs10524523) association a(NIFT:"Cortical Thinning") - pmid:23294633 + pubmed:23183136 - p(HGNC:MAPT, pmod(Ph, Thr, 205)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) + g(DBSNP:rs10524523) association p(HGNC:PSEN1, pmod(go:0006479 ! "protein methylation", Leu, 146)) - pmid:22253473 + pubmed:25862420 - p(HGNC:MAPT, pmod(Ph, Thr, 205)) partOf a(GO:"neurofibrillary tangle") + a(NIFT:"Cortical Thinning") association g(DBSNP:rs10524523) - pmid:21734277 + pubmed:24080518 - p(HGNC:MAPT, pmod(Ph, Thr, 205)) positiveCorrelation p(HBP:"phosphatase-activating domain") + a(NIFT:"Cortical Thinning") association p(HGNC:APOE) - pmid:28784767 + pubmed:26027813 - p(HGNC:MAPT, var("pGly207Val")) increases a(HBP:"Tau aggregates") + a(NIFT:"Cortical Thinning") increases path(MESH:"Alzheimer Disease") - pmid:28784767 + pubmed:21504134 - p(HGNC:MAPT, var("pGly207Val")) increases p(HBP:"Tau aggregates") + a(NIFT:"Cortical Thinning") positiveCorrelation a(NIFT:"Mini mental state exam") - pmid:28784767 + pubmed:24479631 - a(HBP:"Tau Protein Secondary Structure, Turn") decreases a(HBP:"Tau aggregates") + p(HGNC:BCHE) increases a(NIFT:"Cortical Thinning") - pmid:28784767 + pubmed:24479631 - a(HBP:"Tau Protein Secondary Structure, Turn") decreases a(HBP:"Tau aggregates") + p(HGNC:BCHE) increases a(NIFT:"Cortical Thinning") - pmid:28784767 + pubmed:19940480 - a(HBP:"Tau Protein Secondary Structure, Turn") decreases p(HBP:"Tau aggregates") + p(HGNC:BCHE) increases a(NIFT:"Cortical Thinning") - pmid:28784767 + pubmed:19293145 - a(HBP:"Tau Protein Secondary Structure, Turn") decreases p(HBP:"Tau aggregates") + p(HGNC:BCHE) decreases a(CHEBI:acetylcholine) - pmid:28784767 + pubmed:18986241 - p(HGNC:MAPT, var("p.Gly207Val")) decreases a(HBP:"Tau Protein Secondary Structure, Turn") + act(p(HGNC:BCHE), ma(go:0003824 ! "catalytic activity")) directlyIncreases deg(a(CHEBI:acetylcholine)) - pmid:28784767 + pubmed:18986241 - act(p(FPLX:CSNK1), ma(kin)) increases p(HGNC:MAPT, pmod(Ph, Ser, 208)) + p(HGNC:BCHE) association a(MESH:"Neurofibrillary Tangles") - pmid:25673844 + pubmed:18986241 - p(FPLX:CSNK1) isA p(HBP:"CK1 superfamily") + p(HGNC:BCHE) association path(MESH:"Plaque, Amyloid") + + - pmid:25673844 + pubmed:18986241 - p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 42)) + p(HGNC:BCHE) association path(MESH:Cognition) - pmid:25673844 + pubmed:25570489 - p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 45)) + p(HGNC:TF) increases a(NIFT:"Cerebral atrophy") - pmid:25673844 + pubmed:25570489 - p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 47)) + p(HGNC:TF) association a(NIFT:"Cerebral atrophy") - pmid:25673844 + pubmed:25570489 - p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 80)) + a(NIFT:"Cerebral atrophy") association p(HGNC:TF) - pmid:25673844 + pubmed:25570489 - p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 81)) + a(NIFT:"Cerebral atrophy") association p(HGNC:APP) - pmid:25673844 + pubmed:3484831 - p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(Ph, Thr, 84)) + a(NIFT:"Cerebral atrophy") positiveCorrelation p(HGNC:ACHE) - pmid:28784767 + pubmed:3484831 - p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205), pmod(Ph, Thr, 208)) equivalentTo p(HBP:"Tau epitope, AT8") + a(NIFT:"Cerebral atrophy") positiveCorrelation p(HGNC:ACHE) - pmid:29590627 + pubmed:25570489 - p(HGNC:MAPT, var("p.Pro301Ser")) increases path(MESH:"Frontotemporal Dementia") + a(NIFT:"Ventricular expansion") association p(HGNC:ESR1) - pmid:29590627 + pubmed:25570489 - p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + a(NIFT:"Ventricular expansion") association p(HGNC:SORCS1) - pmid:29590627 + pubmed:25027412 - p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) + p(HGNC:TREM2, var("p.Arg47His")) increases a(NIFT:"Temporal lobe atrophy") - pmid:29590627 + pubmed:25027412 - p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + p(HGNC:TREM2, var("p.Arg47His")) increases a(NIFT:"Temporal lobe atrophy") - pmid:29590627 + pubmed:25027412 - p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + p(HGNC:TREM2, var("p.Arg47His")) increases a(NIFT:"Grey matter volume") - pmid:29590627 + pubmed:31413141 - p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + p(HGNC:TREM2, var("p.Arg47His")) causesNoChange p(HGNC:TREM2, frag("?")) - pmid:29590627 + pubmed:29626319 - p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + p(HGNC:TREM2, var("p.Arg47His")) decreases act(a(MESH:Microglia)) - pmid:29590627 + pubmed:29626319 - p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) + p(HGNC:TREM2, var("p.Arg47His")) increases a(CHEBI:amyloid-beta) - pmid:29590627 + pubmed:25027412 - p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) + g(DBSNP:rs75932628) increases a(NIFT:"Temporal lobe atrophy") - pmid:29590627 + pubmed:23533697 - p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) + a(NIFT:"Cerebral blood flow") increases a(NIFT:"Glucose hypometabolism") - pmid:29590627 + pubmed:16151770 - p(HGNC:MAPT, var("p.Pro301Ser")) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + a(NIFT:"Cerebral blood flow") negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:29590627 + pubmed:23300102 - p(HGNC:MAPT, var("p.Pro301Ser")) association a(GO:"early endosome") + a(NIFT:"Cerebral blood flow") negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:29590627 + pubmed:23533697 - p(HGNC:MAPT, var("p.Pro301Ser")) association a(GO:"late endosome") + a(NIFT:"Glucose hypometabolism") increases a(NIFT:"Temporal lobe atrophy") - pmid:29590627 + pubmed:20100581 - p(HGNC:MAPT, var("p.Pro301Ser")) association a(GO:lysosome) + a(NIFT:"Grey matter volume") association path(MESH:"Alzheimer Disease") - pmid:24406748 + pubmed:21547229 - p(HGNC:MAPT, var("p.Pro301Ser")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) + a(NIFT:"Grey matter volume") positiveCorrelation g(DBSNP:rs10932886) - pmid:24406748 + pubmed:26996954 - p(HGNC:MAPT, var("p.Pro301Ser")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 205)) + a(NIFT:"Grey matter volume") association p(HGNC:SORL1) - pmid:24406748 + pubmed:26996954 - p(HGNC:MAPT, var("p.Pro301Ser")) decreases path(MESH:Cognition) + a(NIFT:"Grey matter volume") negativeCorrelation g(DBSNP:rs3824968) - pmid:24406748 + pubmed:25999473 - p(HGNC:MAPT, var("p.Pro301Ser")) increases path(HBP:"mitochondrial dysfunction") + p(HGNC:IDE) increases deg(a(CHEBI:amyloid-beta)) - pmid:24406748 + pubmed:21718217 - p(HGNC:MAPT, var("p.Pro301Ser")) decreases bp(GO:"axonal transport") + p(HGNC:IDE) increases deg(a(CHEBI:amyloid-beta)) - pmid:29590627 + pubmed:30116051 - a(CHEBI:dextran) increases tloc(a(CHEBI:dextran)) + p(HGNC:IDE) increases deg(a(CHEBI:amyloid-beta)) - pmid:28420982 + pubmed:26195256 - a(CHEBI:dextran) association a(HBP:"Tau aggregates") + p(HGNC:IDE) increases deg(a(CHEBI:amyloid-beta, loc(GO:intracellular))) - pmid:29590627 + pubmed:26195256 - a(CHEBI:heparin) causesNoChange tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + p(HGNC:IDE) increases deg(a(CHEBI:amyloid-beta, loc(GO:"extracellular region"))) - pmid:29590627 + pubmed:26195256 - a(CHEBI:heparin) causesNoChange tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + p(HGNC:IDE) increases deg(a(CHEBI:amyloid-beta)) - pmid:25887395 + pubmed:26195256 - a(CHEBI:heparin) decreases a(HBP:"Tau aggregates") + p(HGNC:IDE) decreases a(CHEBI:amyloid-beta) - pmid:29988016 + pubmed:29626319 - a(CHEBI:heparin) negativeCorrelation a(HBP:"Tau aggregates") + p(HGNC:IDE) increases deg(a(CHEBI:amyloid-beta)) - pmid:30108137 + pubmed:29626319 - a(CHEBI:heparin) decreases tloc(a(HBP:"Tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(HGNC:IDE) increases deg(a(CHEBI:amyloid-beta)) - pmid:25887395 + pubmed:29626319 - a(CHEBI:heparin) decreases complex(a(HBP:"Tau fibrils"), p(HGNCGENEFAMILY:Syndecans)) + p(HGNC:IDE) increases deg(a(CHEBI:amyloid-beta)) - pmid:29988016 + pubmed:28019679 - a(CHEBI:heparin) increases act(p(HGNC:MAPT, var("?"))) + p(HGNC:IDE) decreases a(CHEBI:amyloid-beta) - pmid:29686391 + pubmed:30116051 - a(CHEBI:heparin) association tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(HGNC:IDE) increases deg(p(HGNC:IAPP)) - pmid:29686391 + pubmed:30116051 - a(CHEBI:heparin) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(HGNC:IDE) decreases a(CONSO:"alpha-synuclein aggregates") - pmid:26751493 + pubmed:30116051 - a(CHEBI:heparin) association p(HBP:"Tau aggregates") + p(HGNC:IDE) decreases a(CONSO:"amyloid-beta aggregates") - pmid:27601475 + pubmed:30116051 - a(CHEBI:heparin) increases p(HBP:"Tau aggregates") + p(HGNC:IDE) increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:26751493 + pubmed:30116051 - a(CHEBI:heparin) partOf complex(a(CHEBI:heparin), p(HBP:"Tau aggregates")) + p(HGNC:IDE) increases bp(GO:macroautophagy) - pmid:29590627 + pubmed:30116051 - a(CHEBI:dynasore) decreases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + p(HGNC:IDE) decreases a(CONSO:"alpha-synuclein fibrils") - pmid:29590627 + pubmed:30116051 - a(CHEBI:dynasore) decreases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + p(HGNC:IDE) increases deg(a(CONSO:"alpha-synuclein fibrils")) - pmid:29590627 + pubmed:26195256 - a(CHEBI:dynasore) decreases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + p(HGNC:IDE) increases deg(p(HGNC:INS)) - pmid:29686391 + pubmed:29626319 - a(CHEBI:dynasore) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(HGNC:IDE) negativeCorrelation bp(GO:aging) - pmid:29590627 + pubmed:29626319 - a(CHEBI:"cytochalasin D") decreases bp(GO:"actin filament polymerization") + p(HGNC:IDE) negativeCorrelation path(MESH:"Diabetes Mellitus") - pmid:29590627 + pubmed:28019679 - a(CHEBI:"cytochalasin D") negativeCorrelation bp(GO:"bulk synaptic vesicle endocytosis") + p(HGNC:IDE) regulates complex(GO:"NLRP3 inflammasome complex") - pmid:29590627 + pubmed:20100581 - a(CHEBI:"cytochalasin D") negativeCorrelation bp(GO:macropinocytosis) + g(DBSNP:rs6463843) association p(HGNC:NXPH1) - pmid:29590627 + pubmed:20100581 - a(CHEBI:"cytochalasin D") decreases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + g(DBSNP:rs6463843) decreases a(NIFT:"Grey matter volume") - pmid:29590627 + pubmed:20100581 - a(CHEBI:"cytochalasin D") causesNoChange tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + g(DBSNP:rs6463843) increases a(NIFT:"Grey matter atrophy") - pmid:29590627 + pubmed:20100581 - a(CHEBI:"cytochalasin D") causesNoChange tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + p(HGNC:NXPH1) association g(DBSNP:rs6463843) - pmid:29590627 + pubmed:20100581 - bp(GO:"actin filament polymerization") positiveCorrelation bp(GO:"bulk synaptic vesicle endocytosis") + p(HGNC:NXPH1) association path(MESH:"Alzheimer Disease") - pmid:29590627 + pubmed:20100581 - bp(GO:"actin filament polymerization") positiveCorrelation bp(GO:macropinocytosis) + p(HGNC:NXPH1) increases a(NIFT:"Grey matter atrophy") - pmid:29590627 + pubmed:20100581 - bp(GO:"actin filament polymerization") increases tloc(a(HBP:"Tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + p(HGNC:NOS1) association p(HGNC:IFNG) - pmid:24760868 + pubmed:19293145 - bp(GO:"actin filament polymerization") increases complex(GO:"filamentous actin") + act(p(HGNC:NOS1)) increases a(CHEBI:"nitric oxide") - pmid:27041503 + pubmed:20100581 - bp(GO:"actin filament polymerization") increases bp(MESH:"Long-Term Potentiation") + bp(HP:Neurodegeneration) association p(HGNC:APP) - pmid:29590627 + pubmed:24563850 - bp(GO:macropinocytosis) negativeCorrelation a(CHEBI:"cytochalasin D") + bp(HP:Neurodegeneration) association bp(GO:"protein oxidation") - pmid:29590627 + pubmed:30126037 - bp(GO:macropinocytosis) positiveCorrelation bp(GO:"actin filament polymerization") + bp(HP:Neurodegeneration) association p(HGNC:CDKN2A) - pmid:30108137 + pubmed:28420982 - bp(GO:macropinocytosis) increases act(a(MESH:Astrocytes)) + bp(HP:Neurodegeneration) decreases tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:30108137 + pubmed:10936883 - bp(GO:macropinocytosis) increases tloc(a(HBP:"Tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(HGNC:LPL) increases bp(GO:"lipid transport") - pmid:26751493 + pubmed:10936883 - bp(GO:macropinocytosis) positiveCorrelation complex(a(CHEBI:heparin), p(HBP:"Tau aggregates")) + p(HGNC:LPL) increases complex(p(HGNC:APOE), p(HGNC:LRP1B)) - pmid:26751493 + pubmed:10936883 - bp(GO:macropinocytosis) association complex(a(CHEBI:heparin), p(HBP:"Tau aggregates")) + p(HGNC:LPL) increases path(MESH:"Alzheimer Disease") + + - pmid:26751493 + pubmed:10936883 - bp(GO:macropinocytosis) isA tloc(a(HBP:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) + p(HGNC:LPL) increases a(MESH:Hippocampus) - - - pmid:29590627 + pubmed:10936883 - composite(a(CHEBI:dynasore), p(HGNC:MAPT, var("p.Pro301Ser"))) causesNoChange tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + p(HGNC:LPL, var("p.447Ter")) decreases complex(GO:"neurofibrillary tangle") - + + + pubmed:10936883 + + p(HGNC:LPL, var("p.447Ter")) increases a(NIFT:"Cortical Thickness") + - pmid:29590627 + pubmed:10936883 - composite(a(CHEBI:"cytochalasin D"), p(HGNC:MAPT, var("p.Pro301Ser"))) decreases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + a(MESH:Hippocampus) increases path(MESH:Dementia) - pmid:22611162 + pubmed:19126755 - p(HGNC:MAPT, var("p.Lys280del")) increases a(HBP:"Tau aggregates") + a(MESH:Hippocampus) increases p(CONSO:"alpha-4 beta-2 nAChR") - pmid:22611162 + pubmed:19126755 - p(HGNC:MAPT, var("p.Lys280del")) increases a(HBP:"Tau aggregates") + a(MESH:Hippocampus) increases p(HGNC:CHRNA7) - pmid:26631930 + pubmed:19721446 - p(HGNC:MAPT, var("p.Lys280del")) increases a(HBP:"Tau aggregates") + a(MESH:Hippocampus) association p(HGNC:CHRNA7) - pmid:26631930 + pubmed:24511233 - p(HGNC:MAPT, var("p.Lys280del")) increases a(HBP:"Tau aggregates") + a(MESH:Hippocampus) association bp(GO:cognition) - pmid:26631930 + pubmed:24511233 - p(HGNC:MAPT, var("p.Lys280del")) increases a(HBP:"Tau aggregates") + a(MESH:Hippocampus) association bp(GO:learning) - pmid:22611162 + pubmed:24511233 - p(HGNC:MAPT, var("p.Lys280del")) positiveCorrelation p(HGNC:MAPT, pmod(Ph)) + a(MESH:Hippocampus) association bp(GO:learning) - pmid:22611162 + pubmed:24511233 - p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:locomotion) + a(MESH:Hippocampus) association bp(GO:memory) - pmid:22611162 + pubmed:24511233 - p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:"dorsal spinal cord development") + a(MESH:Hippocampus) association bp(GO:memory) - pmid:22611162 + pubmed:19721446 - p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:"dorsal spinal cord development") + a(MESH:Hippocampus) association bp(GO:memory) - pmid:22611162 + pubmed:24511233 - p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:"ventral spinal cord development") + a(MESH:Hippocampus) association p(HGNC:CHRM4) - pmid:22611162 + pubmed:24590577 - p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:"ventral spinal cord development") + a(MESH:Hippocampus) association p(HGNC:CHRM1) - pmid:22611162 + pubmed:24590577 - p(HGNC:MAPT, var("p.Lys280del")) increases path(HBP:neurotoxicity) + a(MESH:Hippocampus) association p(HGNC:CHRM2) - pmid:22611162 + pubmed:24590577 - p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:"nervous system development") + a(MESH:Hippocampus) association p(HGNC:CHRM3) - pmid:26631930 + pubmed:10936883 - p(HGNC:MAPT, var("p.Lys280del")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + complex(p(HGNC:APOE), p(HGNC:LPL), p(HGNCGENEFAMILY:"Low density lipoprotein receptors")) increases path(MESH:"Plaque, Amyloid") + + - pmid:26631930 + pubmed:16340157 - p(HGNC:MAPT, var("p.Lys280del")) decreases p(HBP:"4R tau") + a(NIFT:"Grey matter atrophy") positiveCorrelation path(MESH:Depression) - pmid:26631930 + pubmed:16340157 - p(HGNC:MAPT, var("p.Lys280del")) increases p(HBP:"3R tau") + a(NIFT:"Grey matter atrophy") negativeCorrelation a(MESH:Neurons) - pmid:26631930 + pubmed:16340157 - p(HGNC:MAPT, var("p.Lys280del")) increases bp(GO:memory) + a(NIFT:"Grey matter atrophy") decreases bp(GO:neurogenesis) - pmid:26631930 + pubmed:26996954 - p(HGNC:MAPT, var("p.Lys280del")) increases tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) + a(NIFT:"Grey matter atrophy") positiveCorrelation a(CHEBI:amyloid-beta) - pmid:26631930 + pubmed:19592509 - p(HGNC:MAPT, var("p.Lys280del")) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + p(HGNC:EPHA4) increases a(NIFT:"Grey matter volume") - pmid:26631930 + pubmed:21547229 - p(HGNC:MAPT, var("p.Lys280del")) increases a(GO:"neurofibrillary tangle") + p(HGNC:EPHA4) increases g(DBSNP:rs10932886) - pmid:26631930 + pubmed:21547229 - p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:cognition) + g(DBSNP:rs10932886) positiveCorrelation a(NIFT:"Grey matter volume") - pmid:11606569 + pubmed:21547229 - p(HGNC:MAPT, var("p.Lys280del")) equivalentTo g(DBSNP:rs63750688) + g(DBSNP:rs10932886) increases a(NIFT:"Grey matter atrophy") - pmid:11606569 + pubmed:3122646 - p(HGNC:MAPT, var("p.Lys280del")) positiveCorrelation p(HBP:"VQIINK motif") + a(NIFT:"White matter") association p(HGNC:MAPT) - pmid:11606569 + pubmed:19940480 - p(HGNC:MAPT, var("p.Lys280del")) positiveCorrelation p(HBP:"VQIVYK motif") + a(NIFT:"Brain volume") positiveCorrelation p(HGNC:APOE, var("p.Cys130Arg")) - pmid:22611162 + pubmed:26996954 - p(HGNC:MAPT, var("p.Ile277Pro")) decreases a(HBP:"Tau aggregates") + a(NIFT:"Brain volume") association g(DBSNP:rs3824968) - pmid:22611162 + pubmed:19940480 - p(HGNC:MAPT, var("p.Ile308Pro")) decreases a(HBP:"Tau aggregates") + a(NIFT:"Ventricular volume") negativeCorrelation p(HGNC:APOE, var("p.Cys130Arg")) - pmid:22611162 + pubmed:22711244 - p(HGNC:MAPT, var("p.Val277Met")) association p(HGNC:MAPT, pmod(Ph, Ser, 396)) + p(HGNC:ARHGEF40) positiveCorrelation a(NIFT:"Cortical Thickness") - pmid:22611162 + pubmed:22711244 - p(HGNC:MAPT, var("p.Val277Met")) association p(HGNC:MAPT, pmod(Ph, Ser, 404)) + p(HGNC:ARHGEF40) association g(DBSNP:rs3748348) - pmid:22611162 + pubmed:22711244 - p(HGNC:MAPT, var("p.Val277Met")) increases path(HBP:neurotoxicity) + g(DBSNP:rs3748348) association p(HGNC:ARHGEF40) - pmid:22611162 + pubmed:10449594 - p(HGNC:MAPT, var("p.Val277Met")) decreases bp(GO:"nervous system development") + a(NIFT:Hypoperfusion) positiveCorrelation a(NIFT:"Mini mental state exam") - pmid:22611162 + pubmed:16340157 - a(PUBCHEM:25096749) increases bp(GO:locomotion) + p(HGNC:HSPA5) increases bp(GO:neurogenesis) - pmid:22611162 + pubmed:22040696 - a(PUBCHEM:25096749) decreases a(HBP:"Tau aggregates") + p(HGNC:HSPA5) increases p(FPLX:CHRN) - - - pmid:22611162 - - a(HBP:bb14) increases bp(GO:locomotion) - - - - - pmid:22611162 - - a(HBP:cmp16) decreases a(HBP:"Tau fibrils") - - - - - pmid:22611162 - - a(HBP:cmp16) increases bp(GO:locomotion) - - - pmid:22611162 + pubmed:21722302 - a(HBP:cmp16) decreases path(HP:Neurodegeneration) + p(HGNC:HSPA5) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:24760868 + pubmed:21722302 - p(MESH:Actins) positiveCorrelation bp(GO:"long-term synaptic potentiation") + p(HGNC:HSPA5) biomarkerFor bp(MESH:"Endoplasmic Reticulum Stress") - pmid:24760868 + pubmed:30740335 - p(MESH:Actins) positiveCorrelation bp(GO:"long-term synaptic potentiation") + p(HGNC:HSPA5) association path(MESH:"Unfolded Protein Response") - - - - - pmid:17187063 + pubmed:30740335 - complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) positiveCorrelation a(HBP:Neurodegeneration) + p(HGNC:HSPA5) increases path(MESH:"Unfolded Protein Response") @@ -135229,3792 +137076,3592 @@

Statements

- pmid:24760868 + pubmed:21673407 - a(MESH:jasplakinolide) increases bp(GO:"actin filament polymerization") + p(HGNC:HTR4) association bp(GO:memory) - pmid:24760868 + pubmed:21673407 - a(MESH:jasplakinolide) increases bp(GO:"actin filament polymerization") + p(HGNC:HTR4) association bp(GO:learning) - pmid:24760868 + pubmed:21673407 - a(MESH:jasplakinolide) increases p(HGNC:MAPT) + p(HGNC:HTR4) association tloc(a(CHEBI:acetylcholine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:24760868 + pubmed:21673407 - a(MESH:jasplakinolide) increases p(HGNC:GRIA1) + p(HGNC:HTR4) decreases p(HGNC:APP, frag("672_713")) - - - pmid:24760868 - - a(MESH:jasplakinolide) decreases p(HGNC:FYN) - - - pmid:24760868 + pubmed:21673407 - a(CHEBI:"latrunculin A") increases bp(GO:"actin filament depolymerization") + complex(a(NIFT:"Pittsburgh Compound B"), p(HGNC:HTR4)) positiveCorrelation p(HGNC:APP, frag("672_713")) - - - pmid:24760868 - - a(CHEBI:"latrunculin A") increases bp(GO:"actin filament depolymerization") - - - pmid:24760868 + pubmed:23183136 - a(CHEBI:"latrunculin A") decreases p(HGNC:MAPT) + p(HGNC:PSEN1, pmod(go:0006479 ! "protein methylation", Leu, 146)) association g(DBSNP:rs10524523) - - - - - pmid:29202785 + pubmed:23183136 - a(CHEBI:doxycycline) decreases p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) + p(HGNC:PSEN1, pmod(go:0006479 ! "protein methylation", Leu, 146)) decreases a(NIFT:"Cortical Thickness") - pmid:29202785 + pubmed:22550605 - a(CHEBI:doxycycline) decreases p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) + p(HGNC:TOMM40, var("?")) association path(MESH:"Alzheimer Disease") - pmid:29202785 + pubmed:22550605 - a(CHEBI:doxycycline) decreases p(MGI:Wnt5a) + p(HGNC:TOMM40, var("?")) association a(NIFT:"Hippocampus volume") - pmid:29202785 + pubmed:22550605 - a(CHEBI:doxycycline) decreases p(MGI:Wnt3) + p(HGNC:TOMM40, var("?")) association a(NIFT:Precuneus) - pmid:21734277 + pubmed:22550605 - p(HBP:"Tau 6D") decreases bp(GO:"anterograde axonal protein transport") + a(NIFT:Precuneus) association p(HGNC:TOMM40, var("?")) - pmid:21734277 + pubmed:26996954 - p(HBP:"Tau 6D") decreases bp(GO:"anterograde axonal protein transport") + path(MESH:"Cerebrovascular Disorders") association g(HGNC:SORL1) - pmid:21734277 + pubmed:26996954 - act(p(HBP:"Tau 6D")) decreases bp(GO:"anterograde axonal protein transport") + path(MESH:"Cerebrovascular Disorders") increases path(MESH:Dementia) - pmid:21734277 + pubmed:26996954 - p(HBP:"Tau 6D") causesNoChange bp(GO:"retrograde axonal protein transport") + path(MESH:"Cerebrovascular Disorders") association g(DBSNP:rs3824968) - pmid:21734277 + pubmed:26996954 - p(HBP:"Tau 6D") increases act(p(MESH:"Protein Phosphatase 1")) + a(NIFT:"White Matter Hyperintensity") association g(DBSNP:rs3824968) - pmid:21734277 + pubmed:21871088 - p(HBP:"Tau 6D") increases act(p(MESH:"Glycogen Synthase Kinase 3")) + a(NIFT:"White matter lesion") association bp(GO:"microglial cell activation") - pmid:21734277 + pubmed:21543606 - p(HBP:"Tau 6P") decreases bp(GO:"anterograde axonal protein transport") + bp(GO:"regulation of lipid metabolic process") association a(NIFT:"Fractional anisotropy") - pmid:21734277 + pubmed:21543606 - p(HBP:"Tau 6P") causesNoChange bp(GO:"retrograde axonal protein transport") + bp(GO:"regulation of lipid metabolic process") association bp(GO:myelination) - pmid:21734277 + pubmed:14970312 - act(p(MESH:"Protein Phosphatase 1")) decreases bp(GO:"anterograde axonal protein transport") + bp(GO:"regulation of lipid metabolic process") association bp(MESH:"Oxidative Stress") - pmid:21734277 + pubmed:14970312 - act(p(MESH:"Protein Phosphatase 1")) decreases bp(GO:"anterograde axonal protein transport") + bp(GO:"regulation of lipid metabolic process") association p(HGNC:APP, frag("672_713")) - pmid:21734277 + pubmed:21543606 - act(p(MESH:"Glycogen Synthase Kinase 3")) decreases bp(GO:"anterograde axonal protein transport") + bp(GO:"axonal defasciculation") association bp(GO:"regulation of synaptic plasticity") - pmid:21734277 + pubmed:14970312 - act(p(MESH:"Glycogen Synthase Kinase 3")) decreases bp(GO:"anterograde axonal protein transport") + bp(GO:"sphingolipid metabolic process") association path(MESH:"Alzheimer Disease") - pmid:21734277 + pubmed:14970312 - act(p(MESH:"Glycogen Synthase Kinase 3")) decreases bp(GO:"anterograde axonal protein transport") + bp(GO:"sphingolipid metabolic process") increases a(CHEBI:ceramide) - pmid:21734277 + pubmed:18986241 - p(HBP:"phosphatase-activating domain") increases act(p(HBP:"Tau 6D")) + bp(GO:"sphingolipid metabolic process") association act(p(HGNC:NGFR)) - pmid:21734277 + pubmed:14970312 - p(HBP:"phosphatase-activating domain") decreases bp(GO:"anterograde axonal protein transport") + bp(GO:"cholesterol metabolic process") association path(MESH:"Alzheimer Disease") - pmid:21734277 + pubmed:14970312 - p(HBP:"phosphatase-activating domain") decreases bp(GO:"anterograde axonal protein transport") + bp(GO:"cholesterol metabolic process") increases a(CHEBI:cholesterol) - pmid:21734277 + pubmed:14970312 - p(HBP:"phosphatase-activating domain") decreases bp(GO:"anterograde axonal protein transport") + a(CHEBI:ceramide) increases bp(GO:"neuron death") - pmid:21734277 + pubmed:24653673 - p(HBP:"phosphatase-activating domain") causesNoChange bp(GO:"retrograde axonal protein transport") + a(CHEBI:ceramide) increases act(complex(GO:"protein phosphatase type 2A complex")) - pmid:21734277 + pubmed:29758300 - p(HBP:"phosphatase-activating domain") decreases p(HGNC:JUN, pmod(Ph)) + a(CHEBI:ceramide) regulates bp(GO:"sphingolipid metabolic process") - pmid:21734277 + pubmed:29758300 - p(HBP:"phosphatase-activating domain") increases act(p(MESH:"Phosphoprotein Phosphatases")) + a(CHEBI:ceramide) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:21734277 + pubmed:14970312 - p(HBP:"phosphatase-activating domain") increases act(p(MESH:"Glycogen Synthase Kinase 3")) + a(CHEBI:cholesterol) decreases a(CHEBI:acyl-CoA) - pmid:21734277 + pubmed:21718217 - p(HBP:"phosphatase-activating domain") increases act(p(MESH:"Glycogen Synthase Kinase 3")) + a(CHEBI:cholesterol) increases act(p(HGNC:NR1H3)) - pmid:21734277 + pubmed:19721446 - p(HBP:"phosphatase-activating domain") increases act(p(MESH:"Glycogen Synthase Kinase 3")) + a(CHEBI:cholesterol) association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:21734277 + pubmed:29758300 - p(HBP:"phosphatase-activating domain") increases act(p(MESH:"Protein Phosphatase 1")) + a(CHEBI:cholesterol) increases a(MESH:"Amyloid beta-Peptides") - pmid:21734277 + pubmed:29758300 - p(HBP:"phosphatase-activating domain") increases act(p(MESH:"Protein Phosphatase 1")) + a(CHEBI:cholesterol) regulates act(complex(GO:"gamma-secretase complex")) - pmid:21734277 + pubmed:22908190 - p(HBP:"phosphatase-activating domain") association a(HBP:"Tau antibody, TNT1") + a(CHEBI:cholesterol) positiveCorrelation p(CONSO:"APP C-terminally truncated carboxyl-terminal fragments") - pmid:26671985 + pubmed:22908190 - p(HBP:"phosphatase-activating domain") equivalentTo p(HGNC:MAPT, frag("2_18")) + a(CHEBI:cholesterol) positiveCorrelation bp(GO:endocytosis) - pmid:26671985 + pubmed:22908190 - p(HBP:"phosphatase-activating domain") negativeCorrelation act(complex(GO:axon)) + a(CHEBI:cholesterol) increases a(GO:endosome) - pmid:26671985 + pubmed:14970312 - p(HBP:"phosphatase-activating domain") biomarkerFor path(MESH:"Chronic Traumatic Encephalopathy") + bp(GO:"regulation of sphingomyelin catabolic process") decreases a(CHEBI:ceramide) - pmid:26671985 + pubmed:14970312 - p(HBP:"phosphatase-activating domain") decreases bp(GO:"axonal transport") + bp(GO:"regulation of sphingomyelin catabolic process") decreases a(CHEBI:cholesterol) - pmid:21734277 + pubmed:14970312 - p(HBP:"phosphatase-activating domain") negativeCorrelation bp(GO:"axonal transport") + a(CHEBI:acyl-CoA) decreases bp(GO:"neuron apoptotic process") - pmid:27260838 + pubmed:24189376 - p(HBP:"phosphatase-activating domain") association p(HBP:"Tau antibody, TNT1") + p(HGNC:CNR1) causesNoChange p(HGNC:APP, frag("672_713")) - pmid:27260838 + pubmed:19126755 - p(HBP:"phosphatase-activating domain") association p(HBP:"Tau antibody, TNT2") + p(HGNC:CNR1) association a(CHEBI:anandamide) - pmid:27574109 + pubmed:30061532 - p(HBP:"phosphatase-activating domain") positiveCorrelation p(HBP:"4R tau") + path(MESH:"Lewy Body Disease") association p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:27373205 + pubmed:30061532 - p(HBP:"phosphatase-activating domain") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422)) + path(MESH:"Lewy Body Disease") association a(CHEBI:amyloid-beta) - pmid:21734277 + pubmed:17009926 - p(HBP:"phosphatase-activating domain") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 199)) + path(MESH:"Lewy Body Disease") negativeCorrelation act(p(FPLX:CHRN)) - pmid:21734277 + pubmed:17009926 - p(HBP:"phosphatase-activating domain") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) + path(MESH:"Lewy Body Disease") negativeCorrelation p(FPLX:CHRN) - pmid:21734277 + pubmed:27075649 - p(HBP:"phosphatase-activating domain") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 205)) + path(MESH:"Lewy Body Disease") positiveCorrelation a(CONSO:CONSO00016) - pmid:21734277 + pubmed:29980653 - p(HBP:"phosphatase-activating domain") increases act(p(FPLX:PPP1)) + path(MESH:"Lewy Body Disease") isA path(MESH:"Neurodegenerative Diseases") - pmid:21734277 + pubmed:30837838 - p(HBP:"phosphatase-activating domain") increases act(p(HGNC:GSK3B)) + path(MESH:"Lewy Body Disease") association p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation"), loc(GO:"inclusion body")) - - - - - pmid:21734277 + pubmed:30837838 - composite(p(HBP:"phosphatase-activating domain"), p(HGNC:PPP1R2)) increases bp(GO:"anterograde axonal protein transport") + path(MESH:"Lewy Body Disease") association p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination"), loc(GO:"inclusion body")) - - - pmid:21734277 + pubmed:26091809 - p(HBP:"Tau epitope, AT8", pmod(Ph)) association p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + path(MESH:"Lewy Body Disease") increases path(MESH:Mortality) - pmid:21734277 + pubmed:24590577 - p(HBP:"Tau epitope, AT8", pmod(Ph)) association path(MESH:Tauopathies) + a(CONSO:"Tau aggregates") increases path(MESH:"Neurofibrillary Tangles") - pmid:21734277 + pubmed:24027553 - p(HGNC:MAPT, var("p.144_273del")) decreases bp(GO:"anterograde axonal protein transport") + a(CONSO:"Tau aggregates") increases path(MESH:"Neurofibrillary Tangles") - pmid:21734277 + pubmed:28083634 - p(HGNC:MAPT, var("p.144_273del")) causesNoChange bp(GO:"retrograde axonal protein transport") + a(CONSO:"Tau aggregates") negativeCorrelation p(HGNC:OTUB1) - pmid:21734277 + pubmed:29758300 - a(HBP:"Tau antibody, TNT1") association p(HBP:"phosphatase-activating domain") + a(CONSO:"Tau aggregates") association bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:27373205 + pubmed:23528736 - a(HBP:"Tau antibody, TNT1") association p(HGNC:MAPT, pmod(Ph, Ser, 422)) + a(CONSO:"Tau aggregates") association bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:28528849 + pubmed:29758300 - p(HBP:"Tau oligomers", var("p.Lys280del")) increases p(HBP:"Tau fibrils", var("p.Lys280del")) + a(CONSO:"Tau aggregates") association bp(GO:autophagy) - pmid:28528849 + pubmed:29758300 - p(HBP:"Tau oligomers", var("p.Lys280del")) increases bp(GO:"cell death") + a(CONSO:"Tau aggregates") association complex(a(MESH:"Lipid Bilayers"), p(HGNC:MAPT)) - pmid:28528849 + pubmed:22908190 - p(HBP:"Tau oligomers", var("p.Lys280del")) causesNoChange bp(GO:"cell death") + a(CONSO:"Tau aggregates") increases p(CONSO:"Tau aggregates", pmod(go:0016567 ! "protein ubiquitination")) - pmid:28528849 + pubmed:22908190 - p(HBP:"Tau oligomers", var("p.Lys280del")) increases bp(GO:"apoptotic process") + a(CONSO:"Tau aggregates") decreases act(complex(GO:"proteasome complex")) - pmid:28528849 + pubmed:30116051 - p(HBP:"Tau oligomers", var("p.Lys280del")) increases bp(GO:"negative regulation of mitochondrial membrane potential") + a(CONSO:"Tau aggregates") decreases act(complex(GO:"proteasome complex")) - - - pmid:28528849 - - p(HBP:"Tau oligomers", var("p.Lys280del")) increases act(p(HGNC:CASP3)) - - - pmid:28528849 + pubmed:30116051 - p(HBP:"Tau oligomers", var("p.Lys280del")) increases act(p(HGNC:CASP7)) + a(CONSO:"Tau aggregates") decreases deg(p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) - pmid:28528849 + pubmed:30116051 - p(HBP:"Tau oligomers", var("p.Lys280del")) increases sec(p(HGNC:CYCS)) + a(CONSO:"Tau aggregates") decreases deg(a(CONSO:"Tau oligomers")) - pmid:28528849 + pubmed:30116051 - p(HBP:"Tau oligomers", var("p.Lys280del")) causesNoChange a(GO:membrane) + a(CONSO:"Tau aggregates") decreases bp(GO:"chaperone-mediated autophagy") - pmid:28528849 + pubmed:24027553 - p(HBP:"Tau oligomers", var("p.Lys280del")) decreases a(MESH:"Dendritic Spines") + a(CONSO:"Tau aggregates") positiveCorrelation path(CONSO:neurotoxicity) - pmid:28528849 + pubmed:24027553 - p(HBP:"Tau oligomers", var("p.Lys280del")) decreases a(MESH:"Dendritic Spines") + a(CONSO:"Tau aggregates") decreases act(p(HGNCGENEFAMILY:Proteasome)) - pmid:28528849 + pubmed:24027553 - p(HBP:"Tau oligomers", var("p.Lys280del")) decreases a(MESH:"Dendritic Spines") + a(CONSO:"Tau aggregates") positiveCorrelation a(MESH:Autophagosomes) - pmid:28528849 + pubmed:24027553 - p(HBP:"Tau oligomers", var("p.Lys280del")) decreases a(MESH:"Dendritic Spines") + a(CONSO:"Tau aggregates") positiveCorrelation p(HGNC:MAPT, frag("561_685")) - pmid:28528849 + pubmed:27574109 - p(HBP:"Tau oligomers", var("p.Lys280del")) decreases a(GO:postsynapse) + a(CONSO:"Tau aggregates") decreases bp(GO:"anterograde axonal transport") - pmid:28528849 + pubmed:29590627 - p(HBP:"Tau oligomers", var("p.Lys280del")) decreases p(HGNC:GRIA1) + a(CONSO:"Tau aggregates") increases tloc(a(CONSO:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) - pmid:28528849 + pubmed:29590627 - p(HBP:"Tau oligomers", var("p.Lys280del")) decreases p(HGNC:DBN1) + a(CONSO:"Tau aggregates") increases tloc(a(CONSO:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) - pmid:28528849 + pubmed:29590627 - p(HBP:"Tau oligomers", var("p.Lys280del")) decreases p(HGNC:SYP) + a(CONSO:"Tau aggregates") increases tloc(a(CONSO:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) - pmid:28528849 + pubmed:29590627 - p(HBP:"Tau oligomers", var("p.Lys280del")) increases a(CHEBI:"reactive oxygen species") + a(CONSO:"Tau aggregates") increases tloc(a(CONSO:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) - pmid:28528849 + pubmed:29590627 - p(HBP:"Tau oligomers", var("p.Lys280del")) increases a(CHEBI:"reactive oxygen species") + a(CONSO:"Tau aggregates") increases tloc(a(CONSO:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(GO:"cell body")) - pmid:28528849 + pubmed:26751493 - p(HBP:"Tau oligomers", var("p.Lys280del")) increases p(HGNC:NOX1) + tloc(a(CONSO:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) positiveCorrelation a(CONSO:"Tau aggregates") - pmid:28528849 + pubmed:26751493 - p(HBP:"Tau oligomers", var("p.Lys280del")) increases act(complex(GO:"NADPH oxidase complex")) + a(CONSO:"Tau aggregates") positiveCorrelation tloc(a(CONSO:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) - pmid:28528849 + pubmed:29590627 - p(HBP:"Tau oligomers", var("p.Lys280del")) causesNoChange p(HGNC:CYBB) + a(CONSO:"Tau aggregates") association a(GO:"early endosome") - pmid:28528849 + pubmed:29590627 - p(HBP:"Tau oligomers", var("p.Lys280del")) increases a(CHEBI:"calcium(2+)", loc(GO:intracellular)) + a(CONSO:"Tau aggregates") association a(GO:"late endosome") - pmid:28528849 + pubmed:29590627 - p(HBP:"Tau oligomers", var("p.Lys280del")) causesNoChange p(HGNC:MAPT, pmod(Ph, Ser, 262)) + a(CONSO:"Tau aggregates") association a(GO:lysosome) - pmid:28528849 + pubmed:22611162 - p(HBP:"Tau oligomers", var("p.Lys280del")) causesNoChange p(HGNC:MAPT, pmod(Ph, Ser, 202)) + a(CONSO:"Tau aggregates") increases path(CONSO:proteotoxicity) - pmid:28528849 + pubmed:22611162 - p(HBP:"Tau oligomers", var("p.Lys280del")) causesNoChange p(HGNC:MAPT, pmod(Ph, Thr, 205)) + a(CONSO:"Tau aggregates") decreases bp(GO:"axonal transport") - pmid:28528849 + pubmed:26631930 - p(HBP:"Tau oligomers", var("p.Lys280del")) causesNoChange tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"cell body")) + a(CONSO:"Tau aggregates") decreases bp(GO:"axonal transport") - pmid:28528849 + pubmed:22611162 - p(HBP:"Tau oligomers", var("p.Lys280del")) causesNoChange tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) + a(CONSO:"Tau aggregates") decreases bp(GO:"synaptic signaling") - pmid:28528849 + pubmed:22611162 - p(HBP:"Tau oligomers", var("p.Lys280del")) decreases a(GO:synapse) + a(CONSO:"Tau aggregates") decreases bp(GO:"synaptic signaling") - - - - - pmid:26751493 + pubmed:22611162 - p(HBP:"Tau oligomers") association bp(GO:"clathrin-dependent endocytosis") + a(CONSO:"Tau aggregates") decreases bp(GO:"maintenance of synapse structure") - - - pmid:29238289 + pubmed:22611162 - p(HBP:"Tau fibrils") increases tloc(p(HGNC:MAPT)) + a(CONSO:"Tau aggregates") decreases p(UNIPROT:O02495) - pmid:23702978 + pubmed:22611162 - tloc(p(HGNC:CYCS), fromLoc(MESH:Mitochondria), toLoc(MESH:Cytosol)) increases act(complex(GO:apoptosome)) + a(CONSO:"Tau aggregates") decreases bp(GO:"intracellular distribution of mitochondria") - pmid:23702978 + pubmed:22611162 - tloc(p(HGNC:CYCS), fromLoc(MESH:Mitochondria), toLoc(MESH:Cytosol)) increases complex(p(HGNC:APAF1), p(HGNC:CYCS)) + a(CONSO:"Tau aggregates") decreases bp(GO:"axonal transport of mitochondrion") - pmid:28528849 + pubmed:28528849 - p(HGNC:DBN1) increases bp(GO:"synapse assembly") + a(CONSO:"Tau aggregates") causesNoChange bp(GO:"cell death") - pmid:28528849 + pubmed:26458742 - act(complex(GO:"NADPH oxidase complex")) increases a(CHEBI:"reactive oxygen species") + a(CONSO:"Tau aggregates") causesNoChange bp(GO:"cell death") - pmid:23528736 + pubmed:28528849 - p(HGNC:UBB) positiveCorrelation path(MESH:"Alzheimer Disease") + a(CONSO:"Tau aggregates") causesNoChange a(GO:membrane) - - - pmid:23528736 + pubmed:29988016 - p(HGNC:UBC) positiveCorrelation path(MESH:"Alzheimer Disease") + a(CONSO:"Tau aggregates") negativeCorrelation a(CHEBI:heparin) - pmid:23528736 + pubmed:29988016 - p(HGNC:UBA52) positiveCorrelation path(MESH:"Alzheimer Disease") + a(CONSO:"Tau aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:23528736 + pubmed:27373205 - p(HGNC:RPS27A) positiveCorrelation path(MESH:"Alzheimer Disease") + a(CONSO:"Tau aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:23528736 + pubmed:26631930 - p(HBP:"UBB+1", pmod(Ub)) decreases bp(GO:"protein deubiquitination") + a(CONSO:"Tau aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:23528736 + pubmed:22817713 - p(HBP:"UBB+1", pmod(Ub)) decreases act(p(FPLX:Proteasome)) + a(CONSO:"Tau aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:23528736 + pubmed:21882945 - p(HBP:"UBB+1", pmod(Ub)) regulates path(HP:Neurodegeneration) + a(CONSO:"Tau aggregates") increases path(MESH:Tauopathies) - pmid:23528736 + pubmed:29311797 - p(HBP:"UBB+1", pmod(Ub)) increases bp(MESH:"Stress, Physiological") + a(CONSO:"Tau aggregates") increases path(MESH:Tauopathies) - pmid:23528736 + pubmed:30640040 - p(HBP:"UBB+1", pmod(Ub)) increases act(p(HGNC:TP53)) + a(CONSO:"Tau aggregates") increases bp(GO:"cell killing") - pmid:23528736 + pubmed:29191965 - p(HGNCGENEFAMILY:"Ubiquitin like modifier activating enzymes") negativeCorrelation path(MESH:"Alzheimer Disease") + a(CONSO:"Tau aggregates") decreases act(a(GO:synapse)) - pmid:23528736 + pubmed:29191965 - p(HGNCGENEFAMILY:"Ubiquitin conjugating enzymes E2") negativeCorrelation path(MESH:"Alzheimer Disease") + a(CONSO:"Tau aggregates") decreases a(GO:presynapse) - pmid:23528736 + pubmed:29191965 - p(HGNC:RNF182) association path(MESH:"Neurodegenerative Diseases") + a(CONSO:"Tau aggregates") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:23528736 + pubmed:25374103 - p(HGNC:RNF182) association path(MESH:"Alzheimer Disease") + a(CONSO:"Tau aggregates") increases a(GO:"neurofibrillary tangle") - - - - - - - - - - - pmid:23528736 + pubmed:28420982 - complex(p(HGNC:HSPA8), p(HGNC:STUB1), p(HGNC:UBE2D2)) increases deg(p(HGNC:MAPT)) + a(CONSO:"Tau aggregates") increases a(GO:"neurofibrillary tangle") - pmid:14612456 + pubmed:29844403 - p(HGNC:UBE2D2) positiveCorrelation p(HGNC:MAPT, pmod(Ub)) + a(CONSO:"Tau aggregates") positiveCorrelation a(GO:"neurofibrillary tangle") - pmid:14612456 + pubmed:28877763 - p(HGNC:UBE2D2) isA complex(p(HGNC:MAPT, pmod(Ph)), p(HGNC:STUB1), p(HGNC:UBE2D2)) + a(CONSO:"Tau aggregates") association p(MGI:Syk, pmod(go:0006468 ! "protein phosphorylation", Tyr, 525)) - pmid:23528736 + pubmed:28877763 - p(HGNC:BCL2L11, pmod(Ph)) increases bp(GO:autophagy) + a(CONSO:"Tau aggregates") association p(MGI:Syk, pmod(go:0006468 ! "protein phosphorylation", Tyr, 526)) - pmid:23528736 + pubmed:28877763 - path(HP:"Neurofibrillary tangles") decreases act(p(FPLX:Proteasome)) + a(CONSO:"Tau aggregates") association p(HGNC:SYK, pmod(go:0006468 ! "protein phosphorylation")) - pmid:23528736 + pubmed:28877763 - p(HGNC:DCTN4) decreases a(HBP:"Tau aggregates") + a(CONSO:"Tau aggregates") positiveCorrelation p(HGNC:SYK, pmod(go:0006468 ! "protein phosphorylation")) - pmid:23528736 + pubmed:28420982 - a(CHEBI:"lithium atom") increases bp(GO:autophagy) + a(CONSO:"Tau aggregates") decreases bp(GO:"anterograde axonal protein transport") - pmid:23528736 + pubmed:27373205 - a(CHEBI:"lithium atom") decreases p(HGNC:MAPT) + a(CONSO:"Tau aggregates") decreases bp(GO:"anterograde axonal protein transport") - pmid:23528736 + pubmed:22817713 - a(CHEBI:"lithium atom") decreases path(HP:"Neurofibrillary tangles") + a(CONSO:"Tau aggregates") decreases bp(GO:"anterograde axonal protein transport") - pmid:30108137 + pubmed:22817713 - r(HGNC:TFEB) positiveCorrelation path(MESH:"Cognitive Dysfunction") + a(CONSO:"Tau aggregates") decreases bp(GO:"anterograde axonal protein transport") - pmid:30108137 + pubmed:22817713 - r(HGNC:TFEB) increases path(MESH:Dementia) + a(CONSO:"Tau aggregates") decreases bp(GO:"anterograde axonal protein transport") - pmid:30108137 + pubmed:28420982 - r(HGNC:TFEB) decreases bp(GO:cognition) + a(CONSO:"Tau aggregates") association bp(MESH:"Neuronal Plasticity") - pmid:26702100 + pubmed:28420982 - p(HGNC:LAMP1) association a(GO:lysosome) + a(CONSO:"Tau aggregates") association tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:26702100 + pubmed:28420982 - p(HGNC:LAMP1) association a(GO:lysosome) + a(CONSO:"Tau aggregates") association a(CHEBI:dextran) - - - pmid:30108137 - - act(p(MGI:Tfeb)) association path(MESH:Tauopathies) - - - - - pmid:30108137 - - p(MGI:Tfeb) decreases path(MESH:Tauopathies) - - - pmid:30108137 + pubmed:29311797 - p(MGI:Tfeb) increases p(MGI:Lamp1) + a(CONSO:"Tau aggregates") association p(HGNC:HDAC6) - pmid:30108137 + pubmed:29311797 - p(MGI:Tfeb) increases p(MGI:Ctsa) + a(CONSO:"Tau aggregates") association bp(GO:"glucocorticoid receptor signaling pathway") - pmid:30108137 + pubmed:26458742 - p(MGI:Tfeb) increases p(MGI:Ctsb) + a(CONSO:"Tau aggregates") increases tloc(p(MGI:Mapt), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:Neurons)) - - - pmid:30108137 - - p(MGI:Tfeb) regulates act(a(MESH:Lysosomes)) - + - pmid:30108137 + pubmed:27373205 - p(MGI:Tfeb) increases act(a(MESH:Phagocytes)) + a(CONSO:"Tau aggregates") causesNoChange bp(GO:"retrograde axonal protein transport") - pmid:30108137 + pubmed:26631930 - p(MGI:Tfeb) increases tloc(a(HBP:"Tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + a(CONSO:"Tau aggregates") negativeCorrelation complex(a(GO:microtubule), p(HGNC:MAPT)) - pmid:30108137 + pubmed:26631930 - p(MGI:Tfeb) increases tloc(a(HBP:"Tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + a(CONSO:"Tau aggregates") positiveCorrelation bp(GO:aging) - pmid:30108137 + pubmed:26631930 - p(MGI:Tfeb) increases tloc(a(HBP:"Tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + a(CONSO:"Tau aggregates") decreases bp(GO:"microtubule polymerization") - pmid:30108137 + pubmed:26631930 - p(MGI:Tfeb) increases a(HBP:"Tau fibrils", loc(GO:lysosome)) + a(CONSO:"Tau aggregates") decreases act(a(MESH:Neurons)) - - - pmid:30108137 + pubmed:26631930 - p(MGI:Tfeb) increases p(MGI:Tfeb, loc(GO:nucleus)) + a(CONSO:"Tau aggregates") increases path(CONSO:Neurodegeneration) - pmid:30108137 + pubmed:22817713 - p(MGI:Tfeb, loc(GO:nucleus)) increases act(p(MGI:Tfeb)) + a(CONSO:"Tau aggregates") increases act(p(HGNC:PPP1CA)) - pmid:30108137 + pubmed:22817713 - p(MGI:Tfeb) increases bp(MESH:Phagocytosis) + a(CONSO:"Tau aggregates") increases act(p(HGNC:GSK3A)) - pmid:30108137 + pubmed:22817713 - p(MGI:Tfeb) increases r(MGI:Lamp1) + a(CONSO:"Tau aggregates") association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) - pmid:30108137 + pubmed:22817713 - p(MGI:Tfeb) increases bp(MESH:Proteolysis) + a(CONSO:"Tau aggregates") association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) - - - pmid:30108137 - - p(MGI:Tfeb) causesNoChange p(MGI:Mapt, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) - - - - - pmid:30108137 - - p(MGI:Tfeb) decreases p(MGI:Mapt, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) - + - pmid:30108137 + pubmed:23531502 - p(MGI:Tfeb) causesNoChange p(MGI:Mapt, pmod(Ph, Ser, 202)) + a(CONSO:"Tau aggregates") association act(p(HGNC:GSK3B)) - pmid:30108137 + pubmed:23531502 - p(MGI:Tfeb) decreases p(MGI:Mapt, pmod(Ph, Ser, 202)) + a(CONSO:"Tau aggregates") association act(p(HGNC:MAPK14)) - pmid:30108137 + pubmed:26400044 - p(MGI:Tfeb) decreases p(MGI:Mapt, pmod(Ph, Ser, 202)) + a(CONSO:"Tau aggregates") increases complex(p(CONSO:"Tau aggregates"), p(MGI:Dpysl2, pmod(go:0006468 ! "protein phosphorylation")), p(MGI:Wasf1, pmod(go:0006468 ! "protein phosphorylation"))) - pmid:30108137 + pubmed:28877763 - p(MGI:Tfeb) decreases p(MGI:Mapt, pmod(Ph, Ser, 199), pmod(Ph, Ser, 202), pmod(Ph, Ser, 208)) + a(CONSO:"Tau aggregates") increases act(p(HGNC:SYK)) - pmid:30108137 + pubmed:30061532 - p(MGI:Tfeb) decreases p(MGI:Mapt, pmod(Ph, Thr, 231)) + a(CHEBI:"mTOR inhibitor") decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:30108137 + pubmed:30061532 - p(MGI:Tfeb) causesNoChange p(MGI:Mapt) + a(CHEBI:"mTOR inhibitor") decreases p(HGNC:SNCA, pmod(CONSO:misfolded)) - pmid:30108137 + pubmed:30061532 - p(MGI:Tfeb) decreases p(MGI:Mapt) + a(CHEBI:"mTOR inhibitor") decreases p(HGNC:TARDBP, pmod(CONSO:misfolded)) - pmid:30108137 + pubmed:26010758 - p(MGI:Tfeb) decreases p(MGI:Mapt, pmod(Ph)) + path(MESH:"Interpersonal Relations") association a(CHEBI:amyloid-beta) - pmid:30108137 + pubmed:30061532 - p(MGI:Tfeb) decreases path(MESH:Gliosis) + a(CHEBI:methamphetamine) decreases bp(GO:"dopamine secretion, neurotransmission") - pmid:30108137 + pubmed:30061532 - p(MGI:Tfeb) decreases a(GO:"neurofibrillary tangle") + a(CHEBI:methamphetamine) association bp(GO:"dopamine secretion, neurotransmission") - pmid:30108137 + pubmed:30061532 - a(CHEBI:"torin 1") decreases act(p(FPLX:mTORC1)) + a(CHEBI:methamphetamine) decreases act(p(HGNCGENEFAMILY:"Dopamine receptors")) - pmid:26702100 + pubmed:30061532 - a(CHEBI:"torin 1") isA a(CHEBI:"mTOR inhibitor") + a(CHEBI:methamphetamine) decreases act(p(HGNC:DRD1)) - pmid:26702100 + pubmed:30061532 - a(CHEBI:"torin 1") increases p(HGNC:TFEB, loc(GO:lysosome)) + a(CHEBI:methamphetamine) increases p(HGNC:DRD1) - pmid:26702100 + pubmed:30061532 - a(CHEBI:"torin 1") increases p(HGNC:TFEB, loc(GO:nucleus)) + a(CHEBI:methamphetamine) increases bp(GO:"non-canonical Wnt signaling pathway") - - - - - pmid:30108137 + pubmed:30061532 - composite(a(CHEBI:"torin 1"), p(MGI:Tfeb)) increases tloc(a(HBP:"Tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + a(CHEBI:methamphetamine) increases path(MESH:Hallucinations) - pmid:28877763 + pubmed:30061532 - p(MGI:Mapt, pmod(Ph, Ser, 202)) association p(HGNC:SYK, pmod(Ph)) + a(CHEBI:methamphetamine) increases path(MESH:Delusions) - pmid:29221819 + pubmed:30061532 - p(MGI:Mapt, pmod(Ph, Ser, 202)) positiveCorrelation p(MGI:Dyrk1a) + a(CHEBI:methamphetamine) decreases act(g(HGNC:DISC1)) - pmid:25331948 + pubmed:30061532 - p(MGI:Mapt, pmod(Ph, Ser, 202)) positiveCorrelation p(MGI:Syk) + a(CHEBI:methamphetamine) decreases act(g(HGNC:NRG1)) - pmid:25887395 + pubmed:30061532 - p(HGNC:MAPT, frag("243_375")) increases a(HBP:"Tau fibrils") + a(CHEBI:methamphetamine) decreases act(g(HGNC:DPYSL2)) - - - pmid:25887395 + pubmed:30061532 - complex(a(HBP:"Tau fibrils"), p(HGNCGENEFAMILY:Syndecans)) increases tloc(a(HBP:"Tau fibrils"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + a(CHEBI:methamphetamine) increases path(MESH:"Psychoses, Substance-Induced") - - - pmid:25887395 + pubmed:30061532 - complex(a(HBP:"Tau fibrils"), p(HGNCGENEFAMILY:Syndecans)) increases a(HBP:"Tau aggregates") + a(CHEBI:methamphetamine) decreases act(p(HGNC:SLC6A3)) - - - pmid:29980653 + pubmed:30061532 - p(HGNCGENEFAMILY:Syndecans) increases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + a(CHEBI:methamphetamine) decreases p(HGNC:SLC6A3) - pmid:29980653 + pubmed:30061532 - p(HGNCGENEFAMILY:Syndecans) increases tloc(p(HGNC:SNCA), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + a(CHEBI:methamphetamine) decreases a(CHEBI:dopamine, loc(MESH:"Nerve Endings")) - pmid:29980653 + pubmed:30061532 - p(HGNCGENEFAMILY:Syndecans) association a(MESH:Glycosaminoglycans) + a(CHEBI:methamphetamine) decreases tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:29980653 + pubmed:30061532 - p(HGNCGENEFAMILY:Syndecans) increases tloc(a(HBP:"alpha-synuclein fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + a(CHEBI:methamphetamine) increases a(CHEBI:dopamine, loc(GO:cytosol)) - pmid:25887395 + pubmed:30061532 - a(CHEBI:"sodium chlorate") decreases complex(a(HBP:"Tau fibrils"), p(HGNCGENEFAMILY:Syndecans)) + a(CHEBI:methamphetamine) increases tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:25887395 + pubmed:30061532 - a(CHEBI:"sodium chlorate") decreases p(HGNCGENEFAMILY:Syndecans, pmod(Sulf)) + a(CHEBI:methamphetamine) decreases bp(GO:autophagy) - pmid:25887395 + pubmed:30061532 - a(CHEBI:"sodium chlorate") decreases a(HBP:"Tau aggregates") + a(CHEBI:methamphetamine) decreases act(p(HGNC:SLC18A2)) - pmid:29980653 + pubmed:30061532 - p(HGNCGENEFAMILY:Syndecans, pmod(Sulf)) increases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + a(CHEBI:methamphetamine) negativeCorrelation p(HGNC:SLC18A2) - - - pmid:25887395 + pubmed:30061532 - complex(p(HGNC:MAPT), p(HGNC:MAPT)) causesNoChange tloc(a(HBP:"Tau fibrils"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + a(CHEBI:methamphetamine) increases bp(GO:"response to oxidative stress") - pmid:25887395 + pubmed:30061532 - complex(p(HGNC:MAPT), p(HGNC:MAPT)) causesNoChange a(HBP:"Tau aggregates") + a(CHEBI:methamphetamine) increases act(p(FPLX:AKT)) - pmid:22817713 + pubmed:30061532 - complex(p(HGNC:MAPT), p(HGNC:MAPT)) increases a(HBP:"Tau oligomers") + a(CHEBI:methamphetamine) increases act(p(HGNC:MTOR)) - - - pmid:25887395 + pubmed:19293145 - complex(p(HGNC:MAPT), p(HGNC:MAPT), p(HGNC:MAPT)) increases tloc(a(HBP:"Tau fibrils"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + act(a(CHEBI:methamphetamine)) increases path(CONSO:Neurodegeneration) - pmid:25887395 + pubmed:30061532 - complex(p(HGNC:MAPT), p(HGNC:MAPT), p(HGNC:MAPT)) increases a(HBP:"Tau aggregates") + bp(GO:"dopamine secretion, neurotransmission") association a(CHEBI:methamphetamine) - pmid:29988016 + pubmed:30061532 - complex(p(HGNC:MAPT), p(HGNC:MAPT), p(HGNC:MAPT)) increases a(HBP:"Tau aggregates") + bp(GO:"dopamine secretion, neurotransmission") association bp(GO:autophagy) - - - pmid:25887395 + pubmed:30061532 - complex(p(HGNC:MAPT, frag("243_375")), p(HGNC:MAPT, frag("243_375")), p(HGNC:MAPT, frag("243_375"))) increases a(HBP:"Tau aggregates") + bp(GO:"dopamine secretion, neurotransmission") association p(HGNC:DISC1) - pmid:25887395 + pubmed:30061532 - complex(p(HGNC:MAPT, frag("243_375")), p(HGNC:MAPT, frag("243_375")), p(HGNC:MAPT, frag("243_375"))) increases tloc(a(HBP:"Tau fibrils"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + act(p(HGNC:DRD1)) positiveCorrelation path(MESH:Schizophrenia) - pmid:29988016 + pubmed:30061532 - p(HGNC:MAPT, var("p.Cys299Ala"), var("p.Cys322Ala")) decreases complex(p(HGNC:MAPT, var("p.Cys299Ala"), var("p.Cys322Ala")), p(HGNC:MAPT, var("p.Cys299Ala"), var("p.Cys322Ala"))) + act(p(HGNC:DRD1)) increases act(p(HGNC:MTOR)) - - - pmid:29988016 + pubmed:30061532 - a(PUBCHEM:100984821) increases a(HBP:"Tau aggregates") + act(p(HGNC:DRD1)) increases act(p(HGNC:MTOR)) - pmid:21882945 + pubmed:30061532 - a(PUBCHEM:134222899) positiveCorrelation bp(GO:cognition) + act(p(HGNC:DRD1)) decreases bp(GO:autophagy) - pmid:21882945 + pubmed:30061532 - a(CHEBI:rhodanine) decreases a(HBP:"Tau aggregates") + act(p(HGNC:DRD1)) increases act(p(FPLX:AKT)) - pmid:26751493 + pubmed:30061532 - a(CHEBI:rhodanine) decreases p(HBP:"Tau aggregates") + act(p(HGNC:DRD1)) increases r(HGNC:CDK5) - pmid:21882945 + pubmed:30061532 - a(HBP:"Phenylthiazolyl-hydrazide") decreases a(HBP:"Tau aggregates") + act(p(HGNC:DRD1)) increases p(HGNC:CDK5) - pmid:29191965 + pubmed:30061532 - a(HBP:"Phenylthiazolyl-hydrazide") decreases a(HBP:"Tau aggregates") + p(HGNC:DRD1) increases act(p(HGNC:CDK5)) - pmid:29191965 + pubmed:26979166 - a(HBP:"Phenylthiazolyl-hydrazide") increases bp(GO:locomotion) + act(p(HGNC:DRD1)) decreases act(p(HGNC:CHRNA7)) - pmid:21882945 + pubmed:26979166 - a(PUBCHEM:53789478) decreases a(HBP:"Tau aggregates") + act(p(HGNC:DRD1)) increases act(p(HGNC:PRKACA)) - pmid:21882945 + pubmed:24511233 - a(CHEBI:anthraquinone) decreases a(HBP:"Tau aggregates") + path(MESH:Delusions) association path(MESH:Schizophrenia) - pmid:21882945 + pubmed:24511233 - a(CHEBI:benzothiazoles) decreases a(HBP:"Tau aggregates") + path(MESH:Delusions) biomarkerFor path(MESH:Schizophrenia) - pmid:21882945 + pubmed:19721446 - a(CHEBI:phenothiazines) decreases a(HBP:"Tau aggregates") + path(MESH:Delusions) association path(MESH:Schizophrenia) - pmid:21882945 + pubmed:30061532 - a(CHEBI:polyphenol) decreases a(HBP:"Tau aggregates") + g(HGNC:DISC1) association path(MESH:Schizophrenia) - pmid:21882945 + pubmed:30061532 - a(CHEBI:polyphenol) decreases complex(p(INTERPRO:"Chaperone J-domain superfamily"), p(INTERPRO:"Heat shock protein 70 family")) + g(HGNC:DISC1) association path(MESH:Schizophrenia) - pmid:21882945 + pubmed:30061532 - p(INTERPRO:"Chaperone J-domain superfamily") increases act(p(INTERPRO:"Heat shock protein 70 family")) + act(g(HGNC:DISC1)) association act(p(HGNC:MTOR)) - pmid:21882945 + pubmed:30061532 - p(INTERPRO:"Chaperone J-domain superfamily") increases rxn(reactants(a(CHEBI:ATP)), products(a(CHEBI:"phosphate(3-)"), a(CHEBI:ADP))) + g(HGNC:NRG1) association path(MESH:Schizophrenia) - pmid:21882945 + pubmed:30061532 - a(MESH:"Guanine Nucleotide Exchange Factors") increases act(p(INTERPRO:"Heat shock protein 70 family")) + act(g(HGNC:NRG1)) association act(p(HGNC:MTOR)) - pmid:21882945 + pubmed:21482353 - a(MESH:"Guanine Nucleotide Exchange Factors") increases a(CHEBI:ADP) + g(HGNC:NRG1) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") - - - - - - - pmid:21882945 + pubmed:30061532 - a(PUBCHEM:25195348) decreases act(a(MESH:"Adenosine Triphosphatases")) + g(HGNC:DPYSL2) association path(MESH:Schizophrenia) - pmid:21882945 + pubmed:30061532 - a(PUBCHEM:1056) decreases act(p(INTERPRO:"Heat shock protein 70 family")) + g(HGNC:DPYSL2) association path(MESH:Schizophrenia) - pmid:21882945 + pubmed:30061532 - a(PUBCHEM:1056) regulates complex(p(INTERPRO:"Chaperone J-domain superfamily"), p(INTERPRO:"Heat shock protein 70 family")) + act(g(HGNC:DPYSL2)) association act(p(HGNC:MTOR)) - pmid:21882945 + pubmed:30061532 - a(PUBCHEM:6444403) decreases act(p(INTERPRO:"Heat shock protein 70 family")) + g(HGNC:DPYSL2) increases p(HGNC:DPYSL2) - - - pmid:21882945 + pubmed:30061532 - complex(p(FPLX:HSP90), p(FPLX:HSP90)) increases act(p(FPLX:HSP90)) + a(CHEBI:dopamine) positiveCorrelation path(MESH:Schizophrenia) - pmid:21882945 + pubmed:30061532 - p(INTERPRO:"Tetratricopeptide repeat-containing domain") regulates act(p(FPLX:HSP90)) + tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association path(MESH:Schizophrenia) - - - - - pmid:21882945 + pubmed:30061532 - a(PUBCHEM:9549213) directlyIncreases complex(a(PUBCHEM:9549213), p(INTERPRO:"Heat shock protein Hsp90, N-terminal")) + a(CHEBI:dopamine) regulates bp(GO:autophagy) - pmid:21882945 + pubmed:30061532 - a(PUBCHEM:9549213) directlyDecreases act(p(FPLX:HSP90)) + a(CHEBI:dopamine) association p(HGNC:SLC18A2) - - - - - - - - - pmid:21882945 + pubmed:30061532 - a(CHEBI:novobiocin) directlyIncreases complex(a(CHEBI:novobiocin), p(INTERPRO:"HSP90, C-terminal domain")) + a(CHEBI:dopamine) increases bp(GO:"response to oxidative stress") - pmid:21882945 + pubmed:19126755 - a(CHEBI:novobiocin) directlyDecreases act(p(FPLX:HSP90)) + a(CHEBI:dopamine) decreases path(MESH:"Parkinson Disease") - - - pmid:21882945 + pubmed:21787755 - a(PUBCHEM:501026) directlyIncreases complex(a(PUBCHEM:501026), p(INTERPRO:"HSP90, C-terminal domain")) + tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association r(HGNC:CHRNA6) - pmid:21882945 + pubmed:21787755 - a(PUBCHEM:501026) directlyDecreases act(p(FPLX:HSP90)) + tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association p(HGNC:CHRNA6) - - - - - pmid:21882945 + pubmed:28391535 - a(CHEBI:celastrol) association act(p(FPLX:HSP90)) + a(CHEBI:dopamine) regulates path(MESH:Pleasure) - pmid:29311797 + pubmed:28391535 - a(CHEBI:celastrol) decreases act(p(FPLX:HSP90)) + a(CHEBI:dopamine) regulates path(MESH:Motivation) - pmid:29311797 + pubmed:29687724 - a(CHEBI:celastrol) decreases act(p(HGNC:CDC37)) + a(CHEBI:dopamine) association path(MESH:Chorea) - pmid:29311797 + pubmed:29687724 - a(CHEBI:celastrol) decreases p(HGNC:MAPT) + a(CHEBI:dopamine) association path(MESH:Dystonia) - - - - - - - - - - - - - pmid:21882945 + pubmed:29687724 - complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) increases deg(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) + a(CHEBI:dopamine) association path(MESH:"Huntington Disease") - - - - - pmid:21882945 + pubmed:29687724 - complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) increases deg(p(HGNC:MAPT, pmod(Ph))) + a(CHEBI:dopamine) increases bp(GO:cognition) - pmid:14963027 + pubmed:29687724 - complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) increases deg(p(HGNC:MAPT, pmod(Ph))) + a(CHEBI:dopamine) increases bp(GO:"motor behavior") - pmid:14963027 + pubmed:30027901 - complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph))) increases rxn(reactants(p(HGNC:MAPT, pmod(Ph))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT))) + a(CHEBI:dopamine) increases path(CONSO:Neurodegeneration) - - - - - - - - - - - - - pmid:21882945 + pubmed:30027901 - complex(p(HGNC:BAG1), p(INTERPRO:"Heat shock protein 70 family")) increases p(HGNC:MAPT) + a(CHEBI:dopamine) decreases act(p(HGNCGENEFAMILY:"Mitochondrial complex II: succinate dehydrogenase subunits")) - - - - - - - - - - - pmid:20071522 + pubmed:23393546 - complex(p(FPLX:HSP90), p(HGNC:MAPT)) positiveCorrelation p(HGNC:FKBP5) + a(CHEBI:dopamine) regulates p(HGNC:PPP1R1B) - - - - - pmid:20071522 + pubmed:27075649 - complex(p(HGNC:FKBP5), p(HGNC:MAPT)) association p(HGNC:MAPT, pmod(Ph, Ser, 396)) + a(CHEBI:dopamine) increases a(CONSO:CONSO00093) - pmid:20071522 + pubmed:27075649 - complex(p(HGNC:FKBP5), p(HGNC:MAPT)) association p(HGNC:MAPT, pmod(Ph, Ser, 199)) + a(CHEBI:dopamine) increases a(CONSO:CONSO00093) - pmid:20071522 + pubmed:30061532 - complex(p(HGNC:FKBP5), p(HGNC:MAPT)) association p(HGNC:MAPT, pmod(Ph, Ser, 202)) + a(CHEBI:"lithium(1+)") decreases act(p(HGNC:MTOR)) - - - - - pmid:21882945 + pubmed:30061532 - complex(p(FPLX:HSP90), p(HGNC:FKBP5)) increases complex(a(MESH:"Protein Phosphatase 2"), p(HGNC:MAPT)) + a(CHEBI:"lithium(1+)") decreases path(MESH:Schizophrenia) - pmid:21882945 + pubmed:30061532 - complex(p(FPLX:HSP90), p(HGNC:FKBP5)) increases deg(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) + a(CHEBI:"lithium(1+)") decreases path(MESH:Schizophrenia) - pmid:29311797 + pubmed:30061532 - complex(p(FPLX:HSP90), p(HGNC:FKBP5)) increases a(HBP:"Tau oligomers") + a(CHEBI:"lithium(1+)") decreases path(MESH:"Psychotic Disorders") - - - - - pmid:21882945 + pubmed:18930136 - complex(a(MESH:"Protein Phosphatase 2"), p(HGNC:MAPT)) increases complex(a(GO:microtubule), p(HGNC:MAPT)) + a(CHEBI:"lithium(1+)") increases bp(GO:autophagy) - - - - - pmid:21882945 + pubmed:30116051 - complex(a(MESH:Proteins), p(INTERPRO:"Heat shock protein 70 family")) positiveCorrelation complex(a(MESH:Proteins), p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) + a(CHEBI:"lithium(1+)") increases bp(GO:autophagy) - - - - - - - pmid:21882945 + pubmed:29626319 - complex(a(MESH:Proteins), p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) positiveCorrelation complex(a(MESH:Proteins), p(INTERPRO:"Heat shock protein 70 family")) + a(CHEBI:"lithium(1+)") increases bp(GO:autophagy) - pmid:21882945 + pubmed:27181519 - complex(a(MESH:Proteins), p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) increases bp(GO:"protein polyubiquitination") + a(CHEBI:"lithium(1+)") association bp(GO:autophagy) - - - pmid:21882945 + pubmed:18930136 - complex(a(MESH:Proteins), p(FPLX:HSP90)) increases deg(a(MESH:Proteins)) + a(CHEBI:"lithium(1+)") decreases path(CONSO:Neurodegeneration) - - - - - - - - - - - - - pmid:21882945 + pubmed:30116051 - complex(p(HGNC:VHL), p(INTERPRO:"Heat shock protein 70 family")) increases deg(p(HGNC:VHL)) + a(CHEBI:"lithium(1+)") decreases act(p(HGNC:IMPA1)) - - - - - - - pmid:21882945 + pubmed:30116051 - complex(p(FPLX:HSP90), p(HGNC:VHL)) increases deg(p(HGNC:VHL)) + a(CHEBI:"lithium(1+)") decreases a(PUBCHEM:55310) - - - - - pmid:21882945 + pubmed:30116051 - complex(p(HGNC:STIP1), p(HGNC:VHL)) increases deg(p(HGNC:VHL)) + a(CHEBI:"lithium(1+)") decreases p(HGNC:SNCA) - - - - - pmid:30126037 + pubmed:30116051 - bp(GO:"cellular senescence") association bp(GO:"cell cycle") + a(CHEBI:"lithium(1+)") decreases p(HGNC:SOD1) - pmid:30126037 + pubmed:30116051 - bp(GO:"cellular senescence") increases bp(MESH:"Cell Survival") + a(CHEBI:"lithium(1+)") decreases p(HGNC:HTT) - pmid:30126037 + pubmed:30116051 - bp(GO:"cellular senescence") increases bp(MESH:"Cell Survival") + a(CHEBI:"lithium(1+)") decreases p(HGNC:MAPT) - pmid:30126037 + pubmed:30116051 - bp(GO:"cellular senescence") association bp(MESH:"Cell Survival") + a(CHEBI:"lithium(1+)") increases bp(GO:"motor behavior") - pmid:30126037 + pubmed:30061532 - bp(GO:"cellular senescence") increases bp(GO:"tissue remodeling") + p(HGNC:SLC18A2) association a(CHEBI:dopamine) - pmid:30126037 + pubmed:30061532 - bp(GO:"cellular senescence") increases bp(GO:"tissue remodeling") + p(HGNC:SLC18A2) negativeCorrelation path(MESH:Schizophrenia) - pmid:30126037 + pubmed:30061532 - bp(GO:"cellular senescence") decreases bp(GO:"metabolic process") + p(HGNC:SLC18A2) negativeCorrelation a(CHEBI:methamphetamine) - pmid:30126037 + pubmed:30061532 - bp(GO:"cellular senescence") decreases bp(GO:"metabolic process") + bp(GO:"cytoskeleton organization") negativeCorrelation path(MESH:Schizophrenia) - pmid:30126037 + pubmed:30061532 - bp(GO:"cellular senescence") association p(MGI:Cdkn2a) + bp(GO:"cytoskeleton organization") increases bp(GO:"neuron-neuron synaptic transmission") - pmid:30126037 + pubmed:30061532 - bp(GO:"cellular senescence") increases a(GO:"neurofibrillary tangle") + bp(GO:"cytoskeleton organization") association complex(p(HGNC:CDK5), p(HGNC:DPYSL2)) - pmid:30126037 + pubmed:23516100 - bp(GO:"cellular senescence") association a(GO:"neurofibrillary tangle") + bp(GO:"cytoskeleton organization") negativeCorrelation act(p(HGNCGENEFAMILY:Calpains)) - pmid:30126037 + pubmed:23516100 - bp(GO:"cellular senescence") increases bp(GO:"neuron death") + bp(GO:"cytoskeleton organization") negativeCorrelation path(DOID:"Alzheimer's disease") - pmid:30126037 + pubmed:23454242 - bp(GO:"cellular senescence") increases path(MESH:"Hypertrophy, Right Ventricular") + bp(GO:"cytoskeleton organization") association p(HGNC:PPP2R2A) - pmid:30126037 + pubmed:23454242 - bp(GO:"cellular senescence") increases path(MESH:"Hypertrophy, Left Ventricular") + bp(GO:"cytoskeleton organization") association p(HGNC:PPP2R2B) - pmid:30126037 + pubmed:23454242 - bp(GO:"cellular senescence") increases bp(HP:Neurodegeneration) + bp(GO:"cytoskeleton organization") association p(HGNC:PPP2R2C) - pmid:30126037 + pubmed:29311797 - bp(GO:"cellular senescence") association path(MESH:Tauopathies) + bp(GO:"cytoskeleton organization") association p(HGNC:HSP90AB1) - pmid:30126037 + pubmed:30061532 - bp(GO:"cellular senescence") increases bp(GO:"cell cycle arrest") + complex(a(GO:microtubule), a(MESH:"Microtubule-Associated Proteins")) increases bp(GO:"microtubule polymerization") - - - pmid:30126037 - - bp(GO:"cellular senescence") decreases sec(a(MESH:Immunotoxins)) - + - - - pmid:30126037 - - bp(GO:"cellular senescence") increases bp(MESH:"DNA Damage") - + - pmid:30126037 + pubmed:30061532 - bp(GO:"cellular senescence") association bp(MESH:"DNA Damage") + act(a(GO:microtubule)) negativeCorrelation path(MESH:Schizophrenia) - - - pmid:30126037 - - bp(GO:"cellular senescence") increases p(MGI:Cdkn1a) - + - - - pmid:30126037 - - bp(GO:"cellular senescence") increases p(HGNC:CDKN2A) - + - pmid:30126037 + pubmed:14556719 - bp(GO:"cellular senescence") association bp(GO:"inflammatory response") + a(GO:microtubule) association p(HGNC:MAPT) - pmid:30126037 + pubmed:26631930 - bp(GO:"cellular senescence") increases bp(HBP:HBP00037) + a(GO:microtubule) negativeCorrelation tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) - pmid:29221819 + pubmed:18930136 - bp(GO:"cellular senescence") positiveCorrelation p(MGI:Dyrk1a) + a(GO:microtubule) increases bp(GO:"autophagosome-lysosome fusion") + + - pmid:30126037 + pubmed:8282104 - p(MGI:Cdkn2a) association bp(GO:"cellular senescence") + a(GO:microtubule) association p(HGNC:CDK5) - pmid:30126037 + pubmed:8282104 - p(MGI:Cdkn2a) positiveCorrelation path(HP:"Cerebral atrophy") + a(GO:microtubule) association p(HGNC:PRKACA) - pmid:30126037 + pubmed:8282104 - p(MGI:Cdkn2a) positiveCorrelation a(GO:"neurofibrillary tangle") + a(GO:microtubule) association p(FPLX:ERK) - pmid:30126037 + pubmed:8282104 - p(MGI:Cdkn2a) positiveCorrelation path(HP:"Brain atrophy") + a(GO:microtubule) association p(FPLX:GSK3) + + + + + + + + + + + + - pmid:30126037 + pubmed:16566606 - path(HP:"Cerebral atrophy") positiveCorrelation p(MGI:Cdkn2a) + a(GO:microtubule) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) - pmid:30126037 + pubmed:16566606 - path(MESH:"Hypertrophy, Right Ventricular") association a(GO:"neurofibrillary tangle") + a(GO:microtubule) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 29)) - pmid:30126037 + pubmed:16566606 - path(MESH:"Hypertrophy, Left Ventricular") association a(GO:"neurofibrillary tangle") + a(GO:microtubule) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 197)) - pmid:30126037 + pubmed:16566606 - p(MGI:H2afx) biomarkerFor bp(MESH:"DNA Breaks, Double-Stranded") + a(GO:microtubule) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 394)) + + - pmid:30126037 + pubmed:22692785 - p(MGI:H2afx) biomarkerFor bp(GO:"cellular senescence") + a(MESH:"Microtubule-Associated Proteins") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) - pmid:30126037 + pubmed:22156579 - p(MGI:Glb1) positiveCorrelation a(HP:brain) + a(MESH:"Microtubule-Associated Proteins") positiveCorrelation act(a(CONSO:"amyloid-beta oligomers")) - pmid:30126037 + pubmed:30061532 - a(HP:brain) positiveCorrelation p(MGI:Glb1) + bp(GO:"neuron-neuron synaptic transmission") negativeCorrelation path(MESH:Schizophrenia) - pmid:30126037 + pubmed:30108137 - bp(GO:"oxidative phosphorylation") decreases bp(GO:"oxygen transport") + bp(GO:"neuron-neuron synaptic transmission") association bp(GO:"ATP export") - pmid:30126037 + pubmed:27299292 - path(HP:"Brain atrophy") positiveCorrelation p(MGI:Cdkn2a) + bp(GO:"neuron-neuron synaptic transmission") positiveCorrelation p(HGNC:TFEB) - pmid:30126037 + pubmed:30061532 - path(HP:"Brain atrophy") association a(GO:"neurofibrillary tangle") + a(GO:dendrite) association p(HGNC:DISC1) - - - - - pmid:30126037 + pubmed:30061532 - composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases a(GO:"neurofibrillary tangle") + path(MESH:"Frontotemporal Lobar Degeneration") association path(MESH:"Psychotic Disorders") - pmid:30126037 + pubmed:30061532 - composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases a(GO:"neurofibrillary tangle") + path(MESH:"Frontotemporal Lobar Degeneration") association path(MESH:Catatonia) - pmid:30126037 + pubmed:30061532 - composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases a(GO:"neurofibrillary tangle") + path(MESH:"Frontotemporal Lobar Degeneration") association p(HGNC:TARDBP, loc(GO:"inclusion body")) - pmid:30126037 + pubmed:30061532 - composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases bp(GO:"cellular senescence") + path(MESH:"Frontotemporal Lobar Degeneration") association p(HGNC:TARDBP, loc(CONSO:"dystrophic neurite")) - pmid:30126037 + pubmed:21722302 - composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases bp(GO:"cellular senescence") + path(MESH:"Frontotemporal Lobar Degeneration") association p(HGNC:TARDBP) - pmid:30126037 + pubmed:30837838 - composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases path(HP:"Brain atrophy") + path(MESH:"Frontotemporal Lobar Degeneration") negativeCorrelation act(p(HGNC:TARDBP, loc(GO:nucleus))) - pmid:30126037 + pubmed:30837838 - composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases path(HP:"cardiac ventricle") + path(MESH:"Frontotemporal Lobar Degeneration") increases p(HGNC:TARDBP, loc(GO:"inclusion body")) - pmid:30126037 + pubmed:22908190 - composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases path(HP:"Hyperintensity of cerebral white matter on MRI") + path(MESH:"Frontotemporal Lobar Degeneration") positiveCorrelation p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination")) - pmid:30126037 + pubmed:30837838 - composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases bp(MESH:"Cerebrovascular Circulation") + path(MESH:"Frontotemporal Lobar Degeneration") association p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination")) - pmid:30126037 + pubmed:30837838 - composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) increases p(MGI:Syp) + path(MESH:"Frontotemporal Lobar Degeneration") increases p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination")) - pmid:30126037 + pubmed:26631930 - composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) increases p(MGI:Rbfox3) + path(MESH:"Frontotemporal Lobar Degeneration") association p(HGNC:FUS) - pmid:30126037 + pubmed:30837838 - composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) increases p(MGI:Dlg4) + path(MESH:"Frontotemporal Lobar Degeneration") increases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation")) - pmid:30126037 + pubmed:30837838 - composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) increases p(MGI:Aif1) + path(MESH:"Frontotemporal Lobar Degeneration") increases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation")) - pmid:30126037 + pubmed:30837838 - composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) increases bp(MESH:Neuroprotection) + path(MESH:"Frontotemporal Lobar Degeneration") increases p(HGNC:TARDBP, frag("1_102")) - pmid:30126037 + pubmed:30837838 - path(MESH:"Cerebral Small Vessel Diseases") increases path(HP:"Hyperintensity of cerebral white matter on MRI") + path(MESH:"Frontotemporal Lobar Degeneration") increases p(HGNC:TARDBP, var("p.Ala90Val")) - pmid:30126037 + pubmed:30837838 - path(MESH:"Cerebral Small Vessel Diseases") increases path(MESH:Ischemia) + path(MESH:"Frontotemporal Lobar Degeneration") increases p(HGNC:TARDBP, var("p.Asn267Ser")) - pmid:30126037 + pubmed:30837838 - path(MESH:"Cerebral Small Vessel Diseases") increases path(MESH:"Cognitive Dysfunction") + path(MESH:"Frontotemporal Lobar Degeneration") increases p(HGNC:TARDBP, var("p.Arg361Thr")) - pmid:30126037 + pubmed:30837838 - path(MESH:"Cerebral Small Vessel Diseases") increases path(MESH:Dementia) + path(MESH:"Frontotemporal Lobar Degeneration") increases p(HGNC:TARDBP, var("p.Gly295Ser")) - pmid:28173111 + pubmed:30837838 - p(MGI:Dlg4) negativeCorrelation p(MGI:Dnm1l) + path(MESH:"Frontotemporal Lobar Degeneration") increases p(HGNC:TARDBP, frag("274_414"), pmod(go:0006468 ! "protein phosphorylation")) - pmid:28173111 + pubmed:30837838 - p(MGI:Dlg4) association act(complex(GO:"neuron to neuron synapse")) + path(MESH:"Frontotemporal Lobar Degeneration") association p(HGNC:MAP1LC3A, loc(GO:"inclusion body")) - pmid:28408124 + pubmed:30837838 - a(HBP:"Tau antibody, Tau-13") decreases p(MGI:Mapt, loc(GO:cell)) + path(MESH:"Frontotemporal Lobar Degeneration") association p(HGNC:SQSTM1, loc(GO:"inclusion body")) - pmid:28408124 + pubmed:30061532 - a(HBP:"Tau antibody, Tau-13") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + path(MESH:Catatonia) association path(MESH:"Frontotemporal Lobar Degeneration") - pmid:28408124 + pubmed:30061532 - a(HBP:"Tau antibody, Tau-13") decreases p(HGNC:MAPT, loc(GO:cell)) + path(MESH:Catatonia) association path(MESH:Schizophrenia) - pmid:28408124 + pubmed:30061532 - a(HBP:"Tau antibody, Tau-13") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(HGNC:DISC1) association path(MESH:Schizophrenia) - pmid:28408124 + pubmed:30061532 - a(HBP:"Tau antibody, 6C5") decreases p(MGI:Mapt, loc(GO:cell)) + p(HGNC:DISC1) association path(MESH:Schizophrenia) - pmid:28408124 + pubmed:30061532 - a(HBP:"Tau antibody, 6C5") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(HGNC:DISC1) increases a(CONSO:"protein aggregates") + + + + - pmid:28408124 + pubmed:30061532 - a(HBP:"Tau antibody, 6C5") decreases p(HGNC:MAPT, loc(GO:cell)) + p(HGNC:DISC1) association bp(MESH:Neurogenesis) - pmid:28408124 + pubmed:30061532 - a(HBP:"Tau antibody, 6C5") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(HGNC:DISC1) association bp(GO:"neuron migration") - pmid:28408124 + pubmed:30061532 - a(HBP:"Tau antibody, 6C5") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(HGNC:DISC1) association bp(GO:"axon development") - pmid:28408124 + pubmed:30061532 - a(HBP:"Tau antibody, 6C5") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(HGNC:DISC1) association a(GO:dendrite) - pmid:28408124 + pubmed:30061532 - a(HBP:"Tau antibody, 6C5") decreases a(GO:"neurofibrillary tangle") + p(HGNC:DISC1) association a(GO:synapse) - pmid:28408124 + pubmed:30061532 - a(HBP:"Tau antibody, 6C5") decreases path(MESH:"Plaque, Amyloid") + p(HGNC:DISC1) association bp(GO:"dopamine secretion, neurotransmission") + + - pmid:28408124 + pubmed:30061532 - a(HBP:"Tau antibody, HT7") decreases p(MGI:Mapt, loc(GO:cell)) + p(HGNC:DISC1) decreases act(p(HGNC:CCDC88A)) + + - pmid:28408124 + pubmed:30061532 - a(HBP:"Tau antibody, HT7") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + a(CONSO:"protein aggregates") increases path(MESH:"Neurodegenerative Diseases") - pmid:28408124 + pubmed:29758300 - a(HBP:"Tau antibody, HT7") decreases p(HGNC:MAPT, loc(GO:cell)) + a(CONSO:"protein aggregates") positiveCorrelation path(MESH:"Neurodegenerative Diseases") - pmid:28408124 + pubmed:22020111 - a(HBP:"Tau antibody, HT7") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + a(CONSO:"protein aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:28408124 + pubmed:22020111 - a(HBP:"Tau antibody, 40E8") decreases p(MGI:Mapt, loc(GO:cell)) + a(CONSO:"protein aggregates") positiveCorrelation path(MESH:"Parkinson Disease") - pmid:28408124 + pubmed:22020111 - a(HBP:"Tau antibody, 40E8") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + a(CONSO:"protein aggregates") positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") - pmid:28408124 + pubmed:14556719 - a(HBP:"Tau antibody, 40E8") decreases p(HGNC:MAPT, loc(GO:cell)) + a(CONSO:"protein aggregates") decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + + + + - pmid:28408124 + pubmed:29980653 - a(HBP:"Tau antibody, 40E8") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + a(CONSO:"protein aggregates", loc(MESH:"Central Nervous System")) increases path(CONSO:Neurodegeneration) - pmid:28408124 + pubmed:29980653 - a(HBP:"Tau antibody, 40E8") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + a(CONSO:"protein aggregates") increases path(CONSO:Neurodegeneration) + + - pmid:28408124 + pubmed:27181519 - a(HBP:"Tau antibody, 40E8") decreases p(HGNC:MAPT, pmod(Ph)) + a(CONSO:"protein aggregates") association complex(p(HGNC:OPTN), p(HGNC:TBK1)) - pmid:28408124 + pubmed:30061532 - a(HBP:"Tau antibody, 40E8") decreases a(GO:"neurofibrillary tangle") + p(HGNC:DTNBP1) association path(MESH:Schizophrenia) - pmid:28408124 + pubmed:30061532 - a(HBP:"Tau antibody, 40E8") decreases path(MESH:"Plaque, Amyloid") + p(HGNC:DTNBP1) association path(MESH:Schizophrenia) - pmid:28408124 + pubmed:30061532 - a(HBP:"Tau antibody, 40E8") decreases a(MESH:"Neuropil Threads") + p(HGNC:DTNBP1) increases a(CONSO:"protein aggregates") + + + + - pmid:28408124 + pubmed:30061532 - a(HBP:"Tau antibody, pS396") decreases p(MGI:Mapt, loc(GO:cell)) + p(HGNC:DTNBP1) association a(GO:"microtubule cytoskeleton") - pmid:28408124 + pubmed:30061532 - a(HBP:"Tau antibody, pS396") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(HGNC:DTNBP1) association act(a(GO:cytoskeleton)) - pmid:28408124 + pubmed:30061532 - a(HBP:"Tau antibody, pS396") decreases p(HGNC:MAPT, loc(GO:cell)) + p(HGNC:DTNBP1) association bp(GO:"synaptic vesicle transport") + + + + + + - pmid:28408124 + pubmed:30106381 - a(HBP:"Tau antibody, pS396") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + a(GO:"actin cytoskeleton") association p(HGNC:MTOR) - pmid:28408124 + pubmed:30061532 - a(HBP:"Tau antibody, pS396") decreases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:DPYSL2) association path(MESH:Schizophrenia) - pmid:28408124 + pubmed:30562574 - a(HBP:"Tau antibody, 4E4") decreases p(MGI:Mapt, loc(GO:cell)) + p(HGNC:DPYSL2) association path(MESH:Schizophrenia) + + + + - pmid:28408124 + pubmed:30061532 - a(HBP:"Tau antibody, 4E4") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(HGNC:DPYSL2) association bp(GO:"axon development") - pmid:28408124 + pubmed:30061532 - a(HBP:"Tau antibody, 4E4") decreases p(HGNC:MAPT, loc(GO:cell)) + p(HGNC:DPYSL2) regulates a(GO:"dendritic spine") + + - pmid:28408124 + pubmed:30562574 - a(HBP:"Tau antibody, 4E4") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(HGNC:DPYSL2) isA a(MESH:Neuregulins) - pmid:28408124 + pubmed:30562574 - a(HBP:"Tau antibody, Tau46") decreases p(MGI:Mapt, loc(GO:cell)) + p(HGNC:DPYSL2) increases path(MESH:"Neuronal Outgrowth") - pmid:28408124 + pubmed:30562574 - a(HBP:"Tau antibody, Tau46") causesNoChange tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(HGNC:DPYSL2) increases bp(GO:"neuron projection development") - pmid:28408124 + pubmed:30562574 - a(HBP:"Tau antibody, Tau46") decreases p(HGNC:MAPT, loc(GO:cell)) + p(HGNC:DPYSL2) association path(DOID:schizophrenia) - pmid:28408124 + pubmed:30562574 - a(HBP:"Tau antibody, Tau46") causesNoChange tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(HGNC:DPYSL2) association path(MESH:"Neurodegenerative Diseases") - - - - - pmid:25995053 + pubmed:30061532 - p(MGI:Mapt, pmod(Ph, Ser, 262)) decreases a(GO:"dendritic spine") + a(GO:"microtubule cytoskeleton") association p(HGNC:DTNBP1) - - - - - pmid:28877763 + pubmed:24653673 - p(MGI:Mapt, pmod(Ph, Ser, 396)) positiveCorrelation p(MGI:Syk) + a(GO:"microtubule cytoskeleton") negativeCorrelation act(p(HGNC:GSK3B)) - pmid:25331948 + pubmed:24653673 - p(MGI:Mapt, pmod(Ph, Ser, 396)) positiveCorrelation p(MGI:Syk) + a(GO:"microtubule cytoskeleton") negativeCorrelation act(p(HGNC:CDK5)) - - - - - pmid:25331948 + pubmed:24653673 - a(CHEBI:Nilvadipine) decreases a(CHEBI:"amyloid-beta") + a(GO:"microtubule cytoskeleton") negativeCorrelation act(p(FPLX:ERK)) - pmid:25331948 + pubmed:30061532 - a(CHEBI:Nilvadipine) decreases a(CHEBI:"amyloid-beta") + bp(GO:"synaptic vesicle transport") association p(HGNC:DTNBP1) - pmid:25331948 + pubmed:14556719 - a(CHEBI:Nilvadipine) decreases a(CHEBI:"amyloid-beta") + bp(GO:"synaptic vesicle transport") association p(HGNC:SYT11, pmod(go:0016567 ! "protein ubiquitination")) - pmid:25331948 + pubmed:30061532 - a(CHEBI:Nilvadipine) decreases a(CHEBI:"amyloid-beta") + r(HGNC:MAP6) association act(p(HGNC:MTOR)) - pmid:25331948 + pubmed:30061532 - a(CHEBI:Nilvadipine) increases deg(a(CHEBI:"amyloid-beta")) + p(HGNC:MAP6) association act(p(HGNC:MTOR)) - pmid:25331948 + pubmed:30061532 - a(CHEBI:Nilvadipine) increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:Brain), toLoc(MESH:Blood)) + bp(MESH:Neurogenesis) association p(HGNC:DISC1) - pmid:25331948 + pubmed:30061532 - a(CHEBI:Nilvadipine) decreases act(p(HGNC:APP)) + bp(GO:"neuron migration") association p(HGNC:DISC1) - pmid:25331948 + pubmed:30061532 - a(CHEBI:Nilvadipine) decreases sec(p(HBP:"sAPP-beta")) + p(HGNC:DISC1, var("?")) increases path(MESH:Schizophrenia) - pmid:25331948 + pubmed:30061532 - a(CHEBI:Nilvadipine) decreases sec(p(HBP:"sAPP-beta")) + p(HGNC:DISC1, var("?")) increases path(MESH:Schizophrenia) - pmid:25331948 + pubmed:30061532 - a(CHEBI:Nilvadipine) decreases r(HGNC:BACE1) + p(HGNC:DISC1, var("?")) decreases tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:25331948 + pubmed:30061532 - a(CHEBI:Nilvadipine) decreases r(HGNC:BACE1) + p(HGNC:DISC1, var("?")) increases act(p(FPLX:AKT)) - pmid:25331948 + pubmed:30061532 - a(CHEBI:Nilvadipine) decreases r(HGNC:BACE1) + p(HGNC:DISC1, var("?")) increases act(p(HGNC:MTOR)) - pmid:25331948 + pubmed:30061532 - a(CHEBI:Nilvadipine) decreases p(HGNC:BACE1) + p(HGNC:DISC1, var("?")) decreases bp(GO:autophagy) + + + + - pmid:25331948 + pubmed:30061532 - a(CHEBI:Nilvadipine) decreases p(HGNC:BACE1) + p(HGNC:CCDC88A) increases act(p(FPLX:AKT)) - pmid:25331948 + pubmed:30061532 - a(CHEBI:Nilvadipine) decreases a(CHEBI:"amyloid-beta polypeptide 42") + complex(p(FPLX:AKT), p(HGNC:CCDC88A)) increases act(p(FPLX:AKT)) - pmid:25331948 + pubmed:30061532 - a(CHEBI:Nilvadipine) increases tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(MESH:Brain), toLoc(MESH:Plasma)) + complex(p(HGNC:CCDC88A), p(HGNC:DISC1)) decreases act(p(FPLX:AKT)) - pmid:25331948 + pubmed:30061532 - a(CHEBI:Nilvadipine) increases bp(GO:"amyloid-beta clearance by transcytosis") + complex(p(HGNC:CCDC88A), p(HGNC:DISC1)) decreases act(p(FPLX:AKT)) - pmid:25331948 + pubmed:30061532 - a(CHEBI:Nilvadipine) decreases p(MGI:Mapt, pmod(Ph, Ser, 199)) + complex(p(HGNC:CCDC88A), p(HGNC:DISC1)) decreases act(p(HGNC:MTOR)) - pmid:25331948 + pubmed:30061532 - a(CHEBI:Nilvadipine) decreases p(MGI:Mapt, pmod(Ph, Ser, 202)) + p(MGI:Rictor) decreases bp(GO:"protein kinase B signaling") - pmid:25331948 + pubmed:30061532 - a(CHEBI:Nilvadipine) decreases p(MGI:Mapt, pmod(Ph, Thr, 205)) + p(HGNC:NRG1) association path(MESH:Schizophrenia) - pmid:25331948 + pubmed:30061532 - a(CHEBI:Nilvadipine) decreases p(MGI:Mapt, pmod(Ph, Ser, 396)) + p(HGNC:NRG1) association path(MESH:Schizophrenia) + + - pmid:25331948 + pubmed:30061532 - a(CHEBI:Nilvadipine) decreases p(MGI:Mapt, pmod(Ph, Ser, 404)) + p(HGNC:NRG1) regulates p(HGNC:DISC1) - pmid:25331948 + pubmed:30061532 - a(CHEBI:Nilvadipine) decreases p(HGNC:RAF1, pmod(Ph)) + p(HGNC:NRG1) association bp(GO:"protein kinase B signaling") - pmid:25331948 + pubmed:30061532 - a(CHEBI:Nilvadipine) decreases act(p(HGNC:SYK)) + p(HGNC:NRG1) association act(p(HGNC:MTOR)) - pmid:25331948 + pubmed:30061532 - a(CHEBI:Nilvadipine) increases complex(a(CHEBI:Nilvadipine), p(HGNC:SYK)) + complex(p(HGNC:ERBB4), p(HGNC:NRG1)) regulates bp(GO:"generation of neurons") - pmid:25331948 + pubmed:30061532 - a(CHEBI:Nilvadipine) increases complex(a(CHEBI:Nilvadipine), p(HGNC:SYK)) + complex(p(HGNC:ERBB4), p(HGNC:NRG1)) regulates bp(GO:"neuron-neuron synaptic transmission") - pmid:25331948 + pubmed:30061532 - a(CHEBI:Nilvadipine) decreases act(complex(GO:"NF-kappaB complex")) + act(complex(p(HGNC:ERBB4), p(HGNC:NRG1))) increases tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:25331948 + pubmed:30061532 - a(CHEBI:Nilvadipine) directlyDecreases complex(GO:"L-type voltage-gated calcium channel complex") + complex(p(FPLX:PI3K), p(HGNC:ERBB4)) increases act(p(FPLX:PI3K)) + + - pmid:25331948 + pubmed:30061532 - a(CHEBI:Nilvadipine) decreases p(HGNC:MAPT, pmod(Ph, Ser, 199)) + act(p(FPLX:PI3K), ma(go:0016301 ! "kinase activity")) increases p(FPLX:AKT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:25331948 + pubmed:30061532 - a(CHEBI:Nilvadipine) decreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) + act(p(FPLX:PI3K)) increases act(p(FPLX:AKT)) - pmid:25331948 + pubmed:19293145 - a(CHEBI:Nilvadipine) decreases p(HGNC:MAPT, pmod(Ph, Thr, 205)) + p(FPLX:PI3K) increases act(a(CHEBI:nicotine)) - pmid:25331948 + pubmed:19293145 - a(CHEBI:Nilvadipine) decreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + act(p(FPLX:PI3K)) increases act(a(MESH:"Cholinesterase Inhibitors")) - pmid:25331948 + pubmed:19293145 - a(CHEBI:Nilvadipine) decreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + act(p(FPLX:PI3K)) increases p(HGNC:BAX, pmod(go:0006468 ! "protein phosphorylation")) - pmid:28877763 + pubmed:19293145 - p(MGI:Mapt, pmod(Ph, Ser, 404)) positiveCorrelation p(MGI:Syk) + act(p(FPLX:PI3K)) increases act(p(HGNC:BAD)) - pmid:25331948 + pubmed:19293145 - p(MGI:Mapt, pmod(Ph, Ser, 404)) positiveCorrelation p(MGI:Syk) + p(FPLX:PI3K) increases act(a(MESH:Synapses)) - - - - - pmid:25331948 + pubmed:19293145 - composite(a(CHEBI:Nilvadipine), p(HGNC:TNF)) decreases act(complex(GO:"NF-kappaB complex")) + act(p(FPLX:PI3K)) decreases bp(GO:"apoptotic process") - - - - - pmid:25331948 + pubmed:19293145 - composite(a(CHEBI:"phorbol 13-acetate 12-myristate"), a(CHEBI:Nilvadipine)) decreases act(complex(GO:"NF-kappaB complex")) + p(FPLX:PI3K) regulates act(a(CHEBI:estrogen)) - pmid:25331948 + pubmed:22040696 - a(CHEBI:"phorbol 13-acetate 12-myristate") increases act(p(FPLX:PKC)) + act(p(FPLX:PI3K)) decreases bp(GO:"neuron death") - pmid:25331948 + pubmed:30116051 - a(CHEBI:"phorbol 13-acetate 12-myristate") increases act(complex(GO:"NF-kappaB complex")) + act(p(FPLX:PI3K)) increases a(GO:"autophagosome membrane") - pmid:25331948 + pubmed:30061532 - a(CHEBI:"phorbol 13-acetate 12-myristate") increases p(HGNC:RAF1, pmod(Ph)) + a(GO:"dendritic spine") positiveCorrelation p(HGNC:CDK5) - pmid:25331948 + pubmed:27807169 - a(CHEBI:"phorbol 13-acetate 12-myristate") increases p(HGNC:RAF1, pmod(Ph)) + a(GO:"dendritic spine") positiveCorrelation p(RGD:Cdk5r2) - pmid:25331948 + pubmed:22156579 - a(CHEBI:"phorbol 13-acetate 12-myristate") increases act(p(HGNC:SYK)) + a(GO:"dendritic spine") negativeCorrelation p(HGNC:MARK4) - pmid:25331948 + pubmed:30061532 - a(CHEBI:"phorbol 13-acetate 12-myristate") increases act(p(HGNC:BTK)) + a(CHEBI:amphetamine) increases r(HGNC:CDK5) - - - - - pmid:25331948 + pubmed:30061532 - composite(p(FPLX:RHO), p(HGNC:ROCK1)) increases act(p(HGNC:TNF)) + a(CHEBI:amphetamine) increases p(HGNC:CDK5) - pmid:25331948 + pubmed:24511233 - composite(p(FPLX:RHO), p(HGNC:ROCK1)) increases act(complex(GO:"NF-kappaB complex")) + act(a(CHEBI:amphetamine)) increases bp(GO:locomotion) - pmid:25331948 + pubmed:30061532 - act(p(HGNC:SYK)) regulates act(complex(GO:"NF-kappaB complex")) + p(HGNC:CDK5R1, frag("?")) increases act(p(HGNC:CDK5)) - pmid:25331948 + pubmed:30061532 - p(HGNC:SYK) increases act(complex(GO:"NF-kappaB complex")) + complex(p(HGNC:CDK5), p(HGNC:DPYSL2)) association bp(GO:"cytoskeleton organization") - pmid:25331948 + pubmed:30061532 - p(HGNC:SYK) regulates act(complex(GO:"NF-kappaB complex")) + complex(p(HGNC:CDK5), p(HGNC:DPYSL2)) association path(MESH:"Mental Disorders") - pmid:25331948 + pubmed:30061532 - p(HGNC:SYK) increases a(CHEBI:"amyloid-beta") + path(MESH:"Mental Disorders") association complex(p(HGNC:CDK5), p(HGNC:DPYSL2)) - pmid:25331948 + pubmed:30988501 - act(p(HGNC:SYK)) increases a(CHEBI:"amyloid-beta") + path(MESH:"Mental Disorders") increases path(MESH:Inflammation) - pmid:25331948 + pubmed:30988501 - act(p(HGNC:SYK)) decreases tloc(a(CHEBI:"amyloid-beta"), fromLoc(GO:intracellular), toLoc(MESH:Plasma)) + path(MESH:"Mental Disorders") positiveCorrelation path(MESH:"Psychosocial Deprivation") - pmid:25331948 + pubmed:30061532 - act(p(HGNC:SYK)) increases sec(p(HBP:"sAPP-beta")) + p(HGNC:ULK1, var("?")) association path(MESH:Schizophrenia) - pmid:28877763 + pubmed:30061532 - p(HGNC:SYK) regulates p(HBP:"sAPP-beta") + p(HGNC:BECN1) association bp(GO:autophagy) - pmid:25331948 + pubmed:26968346 - act(p(HGNC:SYK)) increases r(HGNC:BACE1) + p(HGNC:BECN1) positiveCorrelation bp(GO:autophagy) - pmid:25331948 + pubmed:26968346 - act(p(HGNC:SYK)) increases p(HGNC:BACE1) + act(p(HGNC:BECN1)) positiveCorrelation bp(GO:autophagy) - pmid:28877763 + pubmed:18930136 - p(HGNC:SYK) regulates p(HGNC:BACE1) + p(HGNC:BECN1) increases bp(GO:autophagy) - pmid:25331948 + pubmed:26702100 - act(p(HGNC:SYK)) increases p(HGNC:RAF1, pmod(Ph)) + p(HGNC:BECN1) association bp(GO:autophagy) + + - pmid:25331948 + pubmed:26968346 - p(HGNC:SYK) regulates p(HGNC:MAPT, pmod(Ph, Tyr, 18)) + p(HGNC:BECN1) increases deg(p(HGNC:HTT, pmod(CONSO:"CAG repeats"))) + + - pmid:28877763 + pubmed:29758300 - act(p(HGNC:SYK), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 18)) + p(HGNC:BECN1) negativeCorrelation path(MESH:"Alzheimer Disease") + + - pmid:28877763 + pubmed:29758300 - act(p(HGNC:SYK)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 18)) + p(HGNC:BECN1) decreases a(MESH:"Amyloid beta-Peptides") - pmid:28877763 + pubmed:29758300 - p(HGNC:SYK) increases p(HGNC:MAPT, pmod(Ph, Tyr, 18)) + p(HGNC:BECN1) association bp(GO:macroautophagy) - pmid:28877763 + pubmed:29758300 - act(p(HGNC:SYK)) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 18)) + p(HGNC:BECN1) association bp(GO:endocytosis) - pmid:26631930 + pubmed:29758300 - p(HGNC:SYK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 18)) + p(HGNC:BECN1) increases bp(GO:phagocytosis) - pmid:25331948 + pubmed:29758300 - act(p(HGNC:SYK)) increases act(p(HGNC:GSK3B)) + p(HGNC:BECN1) increases tloc(p(HGNC:TREM2), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:28877763 + pubmed:30116051 - p(HGNC:SYK) increases act(p(HGNC:GSK3B)) + act(p(HGNC:BECN1)) increases bp(GO:"autophagosome assembly") + + - pmid:25331948 + pubmed:27260836 - act(p(HGNC:SYK)) increases act(p(HGNC:GSK3B), ma(kin)) + p(HGNC:BECN1) positiveCorrelation p(HGNC:PICALM) - pmid:25331948 + pubmed:30061532 - p(HGNC:SYK) decreases act(p(FPLX:PKA)) + p(HGNC:ULK2) association bp(GO:autophagy) - pmid:25331948 + pubmed:30027901 - p(HGNC:SYK) decreases act(p(FPLX:PKA)) + p(HGNC:ULK2) increases bp(GO:autophagy) - pmid:25331948 + pubmed:30027901 - p(HGNC:SYK) increases p(FPLX:PKA, pmod(Ph, Tyr, 330)) + p(HGNC:ULK2) increases a(MESH:Autophagosomes) - pmid:29191965 + pubmed:30061532 - p(HGNC:SYK) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr)) + p(HGNC:ATG3) association bp(GO:autophagy) @@ -139023,535 +140670,509 @@

Statements

- pmid:28877763 + pubmed:30061532 - act(p(HGNC:SYK)) increases p(HGNC:MAPT, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) + p(HGNC:ADNP) increases bp(GO:"brain development") - - - pmid:28877763 - - p(HGNC:SYK) increases p(HGNC:MAPT, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) - + - pmid:28877763 + pubmed:30106381 - act(p(HGNC:SYK)) increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) + p(HGNC:ADNP) association bp(GO:autophagy) - pmid:28877763 + pubmed:30106381 - act(p(HGNC:SYK)) increases p(HGNC:MAPT, pmod(HBP:misfolded)) + p(HGNC:ADNP) association bp(GO:autophagy) - pmid:28877763 + pubmed:30106381 - act(p(HGNC:SYK)) positiveCorrelation p(HGNC:MAPT, pmod(HBP:misfolded)) + p(HGNC:ADNP) association bp(GO:"cell adhesion") - pmid:28877763 + pubmed:30106381 - p(HGNC:SYK) increases p(HGNC:MAPT) + p(HGNC:ADNP) association bp(GO:"immune response") - pmid:28877763 + pubmed:30106381 - p(HGNC:SYK) regulates deg(p(HGNC:MAPT)) + p(HGNC:ADNP) association path(MESH:"Autistic Disorder") - pmid:28877763 + pubmed:30106381 - p(HGNC:SYK) causesNoChange r(HGNC:MAPT) + p(HGNC:ADNP) association act(a(GO:synapse)) - pmid:28877763 + pubmed:30106381 - act(p(HGNC:SYK)) positiveCorrelation a(HBP:"amyloid-beta aggregates") + p(HGNC:ADNP) association bp(GO:"nervous system development") - pmid:28877763 + pubmed:30106381 - p(HGNC:SYK) increases a(HBP:"Tau aggregates") + p(HGNC:ADNP) association bp(GO:"synapse assembly") - pmid:28877763 + pubmed:30106381 - p(HGNC:SYK) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + p(HGNC:ADNP) positiveCorrelation bp(GO:"synaptic transmission, glutamatergic") - pmid:26501932 + pubmed:30106381 - p(HGNC:SYK) partOf a(HBP:pretangles) + p(HGNC:ADNP) regulates bp(GO:"synapse organization") - pmid:26501932 + pubmed:30106381 - p(HGNC:SYK) partOf a(HBP:"GVD bodies") + p(HGNC:ADNP) regulates bp(GO:"cell communication") - pmid:25331948 + pubmed:30106381 - act(p(HGNC:SYK)) decreases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) + p(HGNC:ADNP) association bp(GO:"AMPA glutamate receptor clustering") - pmid:23702978 + pubmed:30106381 - act(p(HGNC:SYK)) increases complex(p(HGNC:CASP8), p(HGNC:MALT1)) + p(HGNC:ADNP) association bp(GO:learning) - pmid:25331948 + pubmed:30106381 - act(p(HGNC:BTK)) regulates act(complex(GO:"NF-kappaB complex")) + p(HGNC:ADNP) association bp(GO:memory) - pmid:25331948 + pubmed:30664622 - a(PUBCHEM:71656932) decreases act(p(HGNC:BTK)) + p(HGNC:ADNP) increases bp(GO:memory) - pmid:25331948 + pubmed:30106381 - a(PUBCHEM:71656932) causesNoChange a(CHEBI:"amyloid-beta") + p(HGNC:ADNP) association bp(GO:"social behavior") - pmid:25331948 + pubmed:30106381 - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases act(p(HGNC:SYK)) + p(HGNC:ADNP) regulates bp(GO:"ion transport") - pmid:25331948 + pubmed:30106381 - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases act(p(HGNC:SYK)) + p(HGNC:ADNP) association bp(GO:"vocalization behavior") - - - pmid:25331948 - - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases act(complex(GO:"NF-kappaB complex")) - + - pmid:25331948 + pubmed:30106381 - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases a(CHEBI:"amyloid-beta") + p(HGNC:ADNP) regulates g(HGNC:APOE) - pmid:25331948 + pubmed:30106381 - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(GO:intracellular), toLoc(MESH:Plasma)) + p(HGNC:ADNP) association g(HGNC:IQCJ-SCHIP1) - pmid:25331948 + pubmed:30106381 - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases sec(p(HBP:"sAPP-beta")) + p(HGNC:ADNP) association p(HGNC:NLGN2) - pmid:25331948 + pubmed:30106381 - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases r(HGNC:BACE1) + p(HGNC:ADNP) regulates p(HGNC:PAX6) - pmid:25331948 + pubmed:30106381 - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(HGNC:BACE1) + p(HGNC:ADNP) association p(HGNC:WFS1) - pmid:25331948 + pubmed:30106381 - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(MGI:App, frag("1_38")) + p(HGNC:ADNP) association path(MESH:Inflammation) - pmid:25331948 + pubmed:30106381 - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases a(CHEBI:"amyloid-beta polypeptide 42") + p(HGNC:ADNP) association path(MESH:Intelligence) - pmid:25331948 + pubmed:30106381 - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") increases tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:intracellular), toLoc(MESH:Plasma)) + p(HGNC:ADNP) regulates p(HGNC:MTOR) - pmid:25331948 + pubmed:30664622 - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases a(CHEBI:"amyloid-beta polypeptide 40") + p(HGNC:ADNP) decreases path(MESH:"Motor Skills Disorders") - pmid:25331948 + pubmed:30664622 - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(MGI:Mapt, pmod(Ph, Tyr, 18)) + p(HGNC:ADNP) increases a(MESH:"Nerve Fibers, Myelinated") - pmid:25331948 + pubmed:30664622 - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(MGI:Mapt, pmod(Ph, Ser, 396)) + act(p(HGNC:ADNP)) association a(GO:"glutamatergic synapse") - pmid:25331948 + pubmed:30664622 - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(MGI:Mapt, pmod(Ph, Ser, 404)) + p(HGNC:ADNP) increases a(GO:"dendritic spine") - pmid:25331948 + pubmed:30664622 - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(MGI:Mapt, pmod(Ph, Ser, 202)) + act(p(HGNC:ADNP)) association p(HGNC:DLG4) - pmid:25331948 + pubmed:29724491 - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") causesNoChange p(MGI:Mapt, pmod(Ph, Tyr, 231)) + p(HGNC:ADNP) decreases path(MESH:"Intellectual Disability") - pmid:25331948 + pubmed:29724491 - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") increases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) + p(HGNC:ADNP) decreases path(MESH:"Developmental Disabilities") - pmid:25331948 + pubmed:29724491 - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") increases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) + p(HGNC:ADNP) decreases bp(GO:"motor behavior") - - - pmid:25331948 - - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) - - - - - pmid:25331948 - - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) - + - pmid:25331948 + pubmed:30688256 - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) + bp(GO:"autophagosome assembly") increases bp(GO:mitophagy) - pmid:25331948 + pubmed:27299292 - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") causesNoChange p(HGNC:MAPT, pmod(Ph, Tyr, 231)) + bp(GO:"autophagosome assembly") negativeCorrelation path(MESH:"Protein Aggregation, Pathological") - pmid:25331948 + pubmed:30061532 - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(FPLX:AKT, pmod(Ph, Ser, 473)) + a(PUBCHEM:9832404) increases r(HGNC:BECN1) - pmid:25331948 + pubmed:30061532 - a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") increases p(HGNC:CREB1, pmod(Ph)) + a(PUBCHEM:9832404) increases r(HGNC:ADNP) - - - - - pmid:28877763 + pubmed:30061532 - p(HGNC:MAPT, pmod(Ph, Tyr, 18)) positiveCorrelation p(HGNC:SYK, pmod(Ph)) + a(PUBCHEM:9832404) increases complex(p(HGNC:ADNP), p(HGNC:MAP1LC3A)) - pmid:28877763 + pubmed:30061532 - p(HGNC:MAPT, pmod(Ph, Tyr, 18)) positiveCorrelation p(HGNC:SYK, pmod(Ph)) + a(PUBCHEM:9832404) decreases bp(GO:"neuron death") - pmid:28877763 + pubmed:30061532 - p(HGNC:MAPT, pmod(Ph, Tyr, 18)) increases act(p(HGNC:SYK)) + a(PUBCHEM:9832404) increases bp(GO:cognition) - pmid:28877763 + pubmed:30061532 - p(HGNC:MAPT, pmod(Ph, Tyr, 18)) positiveCorrelation act(p(HGNC:SYK)) + a(PUBCHEM:9832404) decreases path(MESH:"Mental Disorders") - pmid:26751493 + pubmed:30106381 - p(HGNC:MAPT, pmod(Ph, Tyr, 18)) positiveCorrelation path(MESH:"Alzheimer Disease") + a(PUBCHEM:9832404) increases a(GO:"dendritic spine") - pmid:26631930 + pubmed:30106381 - p(HGNC:MAPT, pmod(Ph, Tyr, 18)) positiveCorrelation path(MESH:"Alzheimer Disease") + a(PUBCHEM:9832404) increases a(GO:"dendritic spine") - pmid:26631930 + pubmed:30106381 - p(HGNC:MAPT, pmod(Ph, Tyr, 18)) association a(HBP:"paired helical filaments") + a(PUBCHEM:9832404) increases a(GO:"dendritic spine") - pmid:16566606 + pubmed:30664622 - p(HGNC:MAPT, pmod(Ph, Tyr, 18)) positiveCorrelation a(GO:microtubule) + a(PUBCHEM:9832404) increases a(GO:"dendritic spine") - pmid:28877763 + pubmed:30106381 - p(MGI:Mapt, pmod(Ph, Tyr, 18)) positiveCorrelation p(MGI:Syk) + a(PUBCHEM:9832404) decreases p(HGNC:DLG4) - pmid:25331948 + pubmed:30106381 - p(MGI:Mapt, pmod(Ph, Tyr, 18)) positiveCorrelation p(MGI:Syk) + a(PUBCHEM:9832404) decreases p(HGNC:DLG4) - pmid:25331948 + pubmed:30106381 - p(FPLX:PKA, pmod(Ph, Tyr, 330)) decreases act(p(FPLX:PKA)) + a(PUBCHEM:9832404) causesNoChange p(HGNC:DLG4) - pmid:22419736 + pubmed:30106381 - p(HGNC:AK1) positiveCorrelation path(MESH:"Alzheimer Disease") + a(PUBCHEM:9832404) increases p(HGNC:DLG4) - pmid:22419736 + pubmed:30664622 - p(HGNC:AK1) increases act(a(CHEBI:"amyloid-beta polypeptide 42")) + act(a(PUBCHEM:9832404)) association p(HGNC:DLG4) - pmid:22419736 + pubmed:30106381 - p(HGNC:AK1) increases p(HBP:"Tau aggregates") + a(PUBCHEM:9832404) decreases a(GO:"dendritic shaft") - pmid:22419736 + pubmed:30106381 - p(HGNC:AK1) increases p(HGNC:MAPT, pmod(Ph)) + a(PUBCHEM:9832404) decreases a(GO:"dendritic shaft") - pmid:22419736 + pubmed:30106381 - p(HGNC:AK1) negativeCorrelation p(FPLX:AMPK, pmod(Ph, Thr, 172)) + a(PUBCHEM:9832404) increases a(GO:"excitatory synapse") @@ -139560,1140 +141181,1177 @@

Statements

- pmid:22419736 + pubmed:30106381 - p(HGNC:AK1) decreases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) + a(PUBCHEM:9832404) association bp(GO:autophagy) - pmid:22419736 + pubmed:30106381 - p(HGNC:AK1) regulates act(p(HGNC:GSK3B)) + a(PUBCHEM:9832404) association bp(GO:"cell adhesion") - pmid:22419736 + pubmed:30106381 - p(HGNC:AK1) regulates act(p(HGNC:GSK3B)) + a(PUBCHEM:9832404) association bp(GO:"immune response") - pmid:22419736 + pubmed:30106381 - p(HGNC:AK1) regulates act(p(FPLX:AMPK)) + a(PUBCHEM:9832404) association path(MESH:"Autistic Disorder") - pmid:22419736 + pubmed:30106381 - p(HGNC:AK1) increases act(p(HGNC:MAPT)) + a(PUBCHEM:9832404) decreases path(MESH:"Autistic Disorder") - pmid:22419736 + pubmed:30106381 - p(HGNC:AK1) increases path(MESH:"Retinal Degeneration") + a(PUBCHEM:9832404) association act(a(GO:synapse)) - pmid:22419736 + pubmed:30106381 - p(HGNC:AK1) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + a(PUBCHEM:9832404) regulates complex(p(HGNC:ADNP), p(HGNC:AKT1)) - pmid:22419736 + pubmed:30106381 - p(MGI:App, var("c.27269938A>C"), var("c.27269939G>T")) positiveCorrelation p(MGI:Ak1) + a(PUBCHEM:9832404) regulates complex(p(HGNC:ADNP), p(HGNC:DLG4)) - pmid:22419736 + pubmed:30106381 - p(MGI:Ak1) positiveCorrelation p(MGI:App, var("c.27269938A>C"), var("c.27269939G>T")) + a(PUBCHEM:9832404) increases p(HGNC:FPR3) - pmid:22419736 + pubmed:30106381 - p(MGI:Ak1) increases p(MGI:Mapt, pmod(Ph, Ser, 202)) + a(PUBCHEM:9832404) decreases p(HGNC:TUBB1) - pmid:22419736 + pubmed:30106381 - p(MGI:Ak1) increases p(MGI:Mapt, pmod(Ph, Ser, 396)) + a(PUBCHEM:9832404) association p(HGNC:APOE) - pmid:22419736 + pubmed:30106381 - p(MGI:Ak1) increases p(MGI:Mapt, pmod(Ph, Ser, 404)) + a(PUBCHEM:9832404) association g(HGNC:IQCJ-SCHIP1) - pmid:22419736 + pubmed:30106381 - p(MGI:Ak1) increases p(MGI:Mapt, pmod(Ph, Ser, 231)) + a(PUBCHEM:9832404) association g(HGNC:LIPA) - pmid:22419736 + pubmed:30106381 - p(MGI:Ak1) increases p(MGI:Mapt, pmod(Ph, Thr, 235)) + a(PUBCHEM:9832404) association p(HGNC:NLGN2) - - - pmid:22419736 + pubmed:30106381 - p(MESH:"Acetyl-CoA Carboxylase") association act(p(FPLX:AMPK)) + a(PUBCHEM:9832404) association p(HGNC:PAX6) - pmid:22419736 + pubmed:30106381 - p(HGNC:AK1, var("p.Arg132Ala")) causesNoChange p(FPLX:AMPK, pmod(Ph, Thr, 172)) + a(PUBCHEM:9832404) regulates p(HGNC:WFS1) - pmid:22419736 + pubmed:30106381 - p(HGNC:AK1, var("p.Arg132Ala")) causesNoChange p(HGNC:GSK3B, pmod(Ph, Ser, 9)) + a(PUBCHEM:9832404) increases p(HGNC:HIST1H3B) - pmid:22419736 + pubmed:30106381 - a(CHEBI:dorsomorphin) decreases act(p(FPLX:AMPK)) + a(PUBCHEM:9832404) decreases p(HGNC:ABCF3) - pmid:22419736 + pubmed:30106381 - a(CHEBI:dorsomorphin) decreases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) + a(PUBCHEM:9832404) decreases p(HGNC:BMP4) - pmid:22419736 + pubmed:30106381 - a(CHEBI:dorsomorphin) increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + a(PUBCHEM:9832404) decreases p(HGNC:CDH17) - pmid:22419736 + pubmed:30106381 - a(CHEBI:dorsomorphin) increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + a(PUBCHEM:9832404) decreases p(HGNC:KDM5D) - + + + pubmed:30106381 + + a(PUBCHEM:9832404) decreases p(HGNC:KLF1) + - pmid:22419736 + pubmed:30106381 - composite(p(HGNC:AK1), p(HGNC:MAPT)) increases path(MESH:"Retinal Degeneration") + a(PUBCHEM:9832404) decreases p(HGNC:PER1) - pmid:22419736 + pubmed:30106381 - path(MESH:"Retinal Degeneration") association p(HGNC:MAPT, pmod(Ph)) + a(PUBCHEM:9832404) decreases p(HGNC:AKT1) - pmid:30640040 + pubmed:30106381 - act(p(HGNC:FLT1)) increases a(HBP:"Tau aggregates") + a(PUBCHEM:9832404) decreases p(HGNC:AIF1) - pmid:30640040 + pubmed:30106381 - act(p(HGNC:KDR)) increases a(HBP:"Tau aggregates") + a(PUBCHEM:9832404) regulates p(HGNC:MTOR) - pmid:30640040 + pubmed:30106381 - p(HGNC:KDR) association a(PUBCHEM:11154925) + a(PUBCHEM:9832404) increases path(MESH:"Psychomotor Performance") - pmid:30640040 + pubmed:30106381 - p(HGNC:KDR) association a(PUBCHEM:11234052) + a(PUBCHEM:9832404) increases path(MESH:"Psychomotor Performance") - pmid:30640040 + pubmed:30106381 - act(p(FPLX:TGFB)) increases a(HBP:"Tau aggregates") + a(PUBCHEM:9832404) decreases path(MESH:"Vestibular Diseases") - pmid:30640040 + pubmed:30106381 - act(p(FPLX:HDAC)) decreases a(HBP:"Tau aggregates") + a(PUBCHEM:9832404) increases path(MESH:"Motor Activity") - pmid:30640040 + pubmed:30106381 - p(FPLX:HDAC) association a(PUBCHEM:9865515) + a(PUBCHEM:9832404) increases bp(MESH:"Hand Strength") - pmid:27550730 + pubmed:30106381 - act(p(FPLX:HDAC)) negativeCorrelation act(p(FPLX:CREB)) + a(PUBCHEM:9832404) increases path(MESH:"Recognition (Psychology)") - pmid:21427723 + pubmed:30106381 - act(p(FPLX:HDAC)) decreases p(HGNC:MAPT, pmod(Ac)) + a(PUBCHEM:9832404) increases path(MESH:Smell) - pmid:30640040 + pubmed:30106381 - a(PUBCHEM:9804992) decreases act(p(FPLX:HDAC)) + a(PUBCHEM:9832404) increases bp(GO:"social behavior") - pmid:30640040 + pubmed:30664622 - a(PUBCHEM:9804992) increases a(HBP:"Tau aggregates") + a(PUBCHEM:9832404) increases bp(GO:"social behavior") - pmid:30640040 + pubmed:30664622 - a(PUBCHEM:9865515) increases a(HBP:"Tau aggregates") + a(PUBCHEM:9832404) increases bp(GO:"social behavior") + + - pmid:30640040 + pubmed:30664622 - a(PUBCHEM:9865515) association p(FPLX:HDAC) + a(PUBCHEM:9832404) causesNoChange bp(GO:behavior) + + - pmid:30640040 + pubmed:30664622 - a(PUBCHEM:4261) increases a(HBP:"Tau aggregates") + a(PUBCHEM:9832404) decreases path(MESH:"Motor Skills Disorders") - pmid:30640040 + pubmed:30664622 - a(PUBCHEM:4261) association p(HGNC:HDAC1) + a(PUBCHEM:9832404) decreases path(CONSO:Excitotoxicity) - pmid:30640040 + pubmed:30664622 - a(PUBCHEM:4261) association p(HGNC:HDAC3) + act(a(PUBCHEM:9832404)) association a(GO:"glutamatergic synapse") - pmid:30640040 + pubmed:30664622 - a(PUBCHEM:24756910) increases a(HBP:"Tau aggregates") + a(PUBCHEM:9832404) causesNoChange p(HGNC:SLC17A7) - pmid:30640040 + pubmed:30664622 - a(PUBCHEM:24756910) association p(FPLX:"HDAC_I") + a(PUBCHEM:9832404) causesNoChange p(HGNC:SLC17A7) - pmid:30640040 + pubmed:30664622 - a(PUBCHEM:24756910) association p(FPLX:"HDAC_II") + a(PUBCHEM:9832404) increases p(HGNC:SLC17A7) - pmid:30640040 + pubmed:30664622 - a(PUBCHEM:24756910) association p(HGNC:EGFR) + a(PUBCHEM:9832404) increases r(HGNC:SLC17A7) - pmid:30640040 + pubmed:30664622 - a(PUBCHEM:24756910) association p(HGNC:ERBB2) + a(PUBCHEM:9832404) decreases r(HGNC:SLC17A7) - pmid:30640040 + pubmed:30008470 - a(PUBCHEM:448537) increases a(HBP:"Tau aggregates") + a(PUBCHEM:9832404) decreases p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) - pmid:30640040 + pubmed:30008470 - a(PUBCHEM:448537) association p(FPLX:ESR) + a(PUBCHEM:9832404) increases complex(a(GO:microtubule), p(HGNC:ADNP)) - pmid:30640040 + pubmed:30008470 - a(PUBCHEM:5318517) increases a(HBP:"Tau aggregates") + a(PUBCHEM:9832404) increases act(p(HGNC:ADNP)) - pmid:30640040 + pubmed:30061532 - a(PUBCHEM:5318517) association p(FPLX:NFkappaB) + a(MESH:"Antipsychotic Agents") decreases path(MESH:Schizophrenia) - pmid:30640040 + pubmed:30061532 - a(PUBCHEM:5318517) association p(FPLX:Actin) + a(MESH:"Antipsychotic Agents") decreases path(MESH:"Psychotic Disorders") - pmid:30640040 + pubmed:24590577 - a(PUBCHEM:71295844) increases a(HBP:"Tau aggregates") + a(MESH:"Antipsychotic Agents") association a(MESH:"4-(3-(4-butylpiperidin-1-yl)propyl)-7-fluoro-4H-benzo(1,4)oxazin-3-one") - pmid:30640040 + pubmed:30061532 - a(PUBCHEM:71295844) association p(HGNC:GSK3A) + a(PUBCHEM:3396) increases bp(GO:autophagy) - pmid:30640040 + pubmed:30061532 - a(PUBCHEM:71295844) association p(HGNC:GSK3B) + a(CHEBI:trifluoperazine) increases bp(GO:autophagy) - pmid:30640040 + pubmed:30061532 - a(PUBCHEM:42640) increases a(HBP:"Tau aggregates") + a(CHEBI:pimozide) increases bp(GO:autophagy) - pmid:30640040 + pubmed:30061532 - a(PUBCHEM:42640) association p(HGNC:MDM4) + a(CHEBI:pimozide) increases bp(GO:autophagy) - pmid:30640040 + pubmed:30061532 - a(PUBCHEM:2746) increases a(HBP:"Tau aggregates") + a(CHEBI:pimozide) increases act(p(HGNC:PRKAA1)) - pmid:30640040 + pubmed:30061532 - a(PUBCHEM:2746) association p(FPLX:"HDAC_I") + a(CHEBI:pimozide) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation")) - pmid:30640040 + pubmed:30027901 - a(PUBCHEM:71729974) increases a(HBP:"Tau aggregates") + a(CHEBI:pimozide) decreases path(HP:Hyperkinesis) - pmid:30640040 + pubmed:30027901 - a(PUBCHEM:71729974) association p(HGNCGENEFAMILY:"Lysine demethylases") + a(CHEBI:pimozide) causesNoChange path(MESH:"Motor Disorders") - pmid:30640040 + pubmed:30061532 - a(PUBCHEM:53340666) increases a(HBP:"Tau aggregates") + act(p(HGNC:PRKAA1)) increases p(HGNC:ULK1, pmod(go:0006468 ! "protein phosphorylation")) + + - pmid:30640040 + pubmed:21722302 - a(PUBCHEM:53340666) association p(HGNC:HDAC6) + p(HGNC:PRKAA1) negativeCorrelation p(HGNC:MTOR) - pmid:24844691 + pubmed:21722302 - a(PUBCHEM:53340666) directlyDecreases act(p(HGNC:HDAC6)) + p(HGNC:PRKAA1) decreases p(HGNC:MTOR) - pmid:24844691 + pubmed:21722302 - a(PUBCHEM:53340666) increases bp(GO:behavior) + p(HGNC:PRKAA1) regulates p(HGNCGENEFAMILY:"TSC complex") - pmid:24844691 + pubmed:29758300 - a(PUBCHEM:53340666) decreases a(CHEBI:"amyloid-beta") + p(HGNC:PRKAA1) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) - pmid:24844691 + pubmed:30061532 - a(PUBCHEM:53340666) decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + a(CHEBI:chlorpromazine) increases bp(GO:autophagy) - pmid:24844691 + pubmed:30061532 - a(PUBCHEM:53340666) increases p(FPLX:Tubulin, pmod(Ac)) + a(CHEBI:chlorpromazine) decreases bp(GO:"protein kinase B signaling") - pmid:24844691 + pubmed:30061532 - a(PUBCHEM:53340666) increases bp(GO:autophagy) + a(CHEBI:chlorpromazine) decreases act(p(HGNC:MTOR)) + + - pmid:30640040 + pubmed:23038257 - a(PUBCHEM:11154925) decreases a(HBP:"Tau aggregates") + a(CHEBI:chlorpromazine) association complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) - pmid:30640040 + pubmed:23038257 - a(PUBCHEM:11154925) association p(HGNC:KDR) + a(CHEBI:chlorpromazine) association p(HGNC:SCNN1D) - pmid:30640040 + pubmed:30027901 - a(PUBCHEM:4521392) decreases a(HBP:"Tau aggregates") + a(CHEBI:chlorpromazine) decreases path(MESH:"Huntington Disease") - pmid:30640040 + pubmed:30061532 - a(PUBCHEM:4521392) association p(HGNC:TGFBR1) + a(CHEBI:sertindole) increases bp(GO:autophagy) - pmid:30640040 + pubmed:30061532 - a(PUBCHEM:11234052) decreases a(HBP:"Tau aggregates") + a(CHEBI:clozapine) increases bp(GO:autophagy) - pmid:30640040 + pubmed:30061532 - a(PUBCHEM:11234052) association p(HGNC:KDR) + a(CHEBI:clozapine) increases bp(GO:autophagy) - pmid:30640040 + pubmed:30061532 - a(PUBCHEM:46209426) decreases a(HBP:"Tau aggregates") + a(CHEBI:clozapine) increases p(HGNC:PRKAA1, pmod(go:0006468 ! "protein phosphorylation")) - pmid:30640040 + pubmed:30061532 - a(PUBCHEM:46209426) association p(FPLX:ROCK) + a(CHEBI:clozapine) increases p(HGNC:ULK1, pmod(go:0006468 ! "protein phosphorylation")) - pmid:30640040 + pubmed:30061532 - a(PUBCHEM:6321424) decreases a(HBP:"Tau aggregates") + a(CHEBI:clozapine) increases p(HGNC:BECN1, pmod(go:0006468 ! "protein phosphorylation")) - pmid:30640040 + pubmed:30061532 - a(PUBCHEM:6321424) increases act(p(HGNCGENEFAMILY:"Chloride channel accessory")) + a(CHEBI:clozapine) increases a(GO:autophagosome) - pmid:30640040 + pubmed:30061532 - a(PUBCHEM:11570805) decreases a(HBP:"Tau aggregates") + a(CHEBI:clozapine) decreases a(CHEBI:amyloid-beta) - pmid:30640040 + pubmed:19721446 - a(PUBCHEM:11570805) association p(HGNC:MAPK14) + a(CHEBI:clozapine) increases bp(MESH:"Sensory Gating") - pmid:30640040 + pubmed:19721446 - a(PUBCHEM:156422) decreases a(HBP:"Tau aggregates") + a(CHEBI:clozapine) association p(HGNC:CHRNA7) - pmid:30640040 + pubmed:30116051 - a(PUBCHEM:156422) association p(HGNC:MAPK14) + p(HGNC:BECN1, pmod(go:0006468 ! "protein phosphorylation")) increases act(p(HGNC:BECN1)) - pmid:30640040 + pubmed:30027901 - a(PUBCHEM:9880) decreases a(HBP:"Tau aggregates") + a(GO:autophagosome) decreases deg(a(MESH:"Protein Aggregates")) - pmid:30640040 + pubmed:21722302 - a(PUBCHEM:9880) decreases act(p(HGNC:AR)) + a(GO:autophagosome) association path(MESH:"Alzheimer Disease") - pmid:30640040 + pubmed:22908190 - a(PUBCHEM:3033825) decreases a(HBP:"Tau aggregates") + a(GO:autophagosome) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:30640040 + pubmed:18930136 - a(PUBCHEM:3033825) association p(HGNC:TNC) + a(GO:autophagosome) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:30640040 + pubmed:18930136 - a(PUBCHEM:5311272) decreases a(HBP:"Tau aggregates") + a(GO:autophagosome) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + + + + - pmid:30640040 + pubmed:22908190 - a(PUBCHEM:5311272) decreases act(p(FPLX:"Gamma_secretase")) + a(GO:autophagosome) association a(CONSO:"dystrophic neurite") - pmid:30640040 + pubmed:22908190 - a(PUBCHEM:49806720) decreases a(HBP:"Tau aggregates") + a(GO:autophagosome) increases a(GO:organelle) - pmid:30640040 + pubmed:22908190 - a(PUBCHEM:49806720) decreases act(p(HGNC:ALK)) + a(GO:autophagosome) association p(HGNC:APP) - pmid:30640040 + pubmed:18930136 - a(PUBCHEM:9839311) decreases a(HBP:"Tau aggregates") + a(GO:autophagosome) increases bp(GO:autophagy) - pmid:30640040 + pubmed:18930136 - a(PUBCHEM:9839311) association p(HGNC:SELE) + a(GO:autophagosome) increases bp(GO:"autophagosome-lysosome fusion") + + - pmid:30640040 + pubmed:18930136 - a(PUBCHEM:9839311) association p(HGNC:ICAM1) + a(GO:autophagosome) increases complex(a(GO:"multivesicular body"), a(GO:autophagosome), a(GO:endosome)) + + - pmid:30640040 + pubmed:18930136 - a(PUBCHEM:447966) decreases a(HBP:"Tau aggregates") + a(GO:autophagosome) association complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:MAP1LC3B)) - pmid:30640040 + pubmed:18930136 - a(PUBCHEM:447966) association p(HGNC:TGFBR1) + a(GO:autophagosome) positiveCorrelation path(MESH:"Parkinson Disease") - pmid:30640040 + pubmed:18930136 - a(PUBCHEM:11655119) decreases a(HBP:"Tau aggregates") + a(GO:autophagosome) positiveCorrelation path(MESH:"Creutzfeldt-Jakob Syndrome") - pmid:30640040 + pubmed:18930136 - a(PUBCHEM:11655119) association p(HGNC:TGFBR1) + a(GO:autophagosome) negativeCorrelation p(HGNC:CTSD) - pmid:30640040 + pubmed:18930136 - a(PUBCHEM:11655119) association p(HGNC:TGFBR2) + a(GO:autophagosome) positiveCorrelation p(HGNC:DCTN1, var("?")) + + - pmid:30640040 + pubmed:24027553 - a(PUBCHEM:10435235) decreases a(HBP:"Tau aggregates") + p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation")) increases path(CONSO:Neurodegeneration) - pmid:30640040 + pubmed:30126037 - a(PUBCHEM:10435235) decreases act(p(FPLX:"Gamma_secretase")) + p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation")) causesNoChange p(MGI:Cdkn2a) - pmid:30640040 + pubmed:28173111 - a(PUBCHEM:5833) decreases a(HBP:"Tau aggregates") + p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation r(MGI:Dnm1l) + + - pmid:30640040 + pubmed:30061532 - a(PUBCHEM:5833) association p(HGNC:AR) + a(CHEBI:haloperidol) decreases a(CONSO:"huntingtin aggregates") - pmid:30640040 + pubmed:30027901 - a(PUBCHEM:10341154) decreases a(HBP:"Tau aggregates") + a(CHEBI:haloperidol) decreases path(MESH:"Huntington Disease") - pmid:30640040 + pubmed:30027901 - a(PUBCHEM:10341154) association p(HGNC:MAPK14) + a(CHEBI:haloperidol) causesNoChange path(MESH:Chorea) - pmid:30640040 + pubmed:30027901 - a(PUBCHEM:4878) decreases a(HBP:"Tau aggregates") + a(CHEBI:haloperidol) decreases path(MESH:Chorea) + + - pmid:30640040 + pubmed:30027901 - a(PUBCHEM:4878) association p(HGNC:LCK) + a(CHEBI:haloperidol) increases path(MESH:Depression) - pmid:30640040 + pubmed:30027901 - a(PUBCHEM:4878) association p(HGNC:FYN) + a(CHEBI:haloperidol) decreases path(HP:Hyperkinesis) - pmid:30640040 + pubmed:30027901 - p(HGNC:HDAC1) association a(PUBCHEM:4261) + a(CHEBI:haloperidol) causesNoChange path(MESH:"Motor Disorders") - pmid:30640040 + pubmed:30027901 - p(HGNC:HDAC3) association a(PUBCHEM:4261) + a(CHEBI:haloperidol) causesNoChange bp(GO:"walking behavior") - pmid:28771976 + pubmed:30027901 - p(HGNC:HDAC3) increases a(CHEBI:"amyloid-beta") + a(CHEBI:haloperidol) increases path(HP:Parkinsonism) - pmid:28771976 + pubmed:30027901 - p(HGNC:HDAC3) increases bp(GO:"microglial cell activation") + a(CHEBI:haloperidol) increases path(HP:"Tardive dyskinesia") - pmid:28771976 + pubmed:30027901 - p(HGNC:HDAC3) decreases a(GO:"dendritic spine") + a(CHEBI:haloperidol) increases path(HP:Dysphasia) - pmid:30640040 + pubmed:30027901 - p(FPLX:"HDAC_I") association a(PUBCHEM:24756910) + a(CONSO:"huntingtin aggregates") regulates bp(MESH:"Cell Survival") - pmid:30640040 + pubmed:30027901 - p(FPLX:"HDAC_I") association a(PUBCHEM:2746) + a(CONSO:"huntingtin aggregates") regulates bp(GO:"cell death") - pmid:30640040 + pubmed:30027901 - p(FPLX:"HDAC_II") association a(PUBCHEM:24756910) + a(CONSO:"huntingtin aggregates") decreases bp(GO:"necrotic cell death") - pmid:30640040 + pubmed:30027901 - p(HGNC:ERBB2) association a(PUBCHEM:24756910) + a(CONSO:"huntingtin aggregates") increases bp(GO:autophagy) - pmid:30640040 + pubmed:30027901 - p(FPLX:ESR) association a(PUBCHEM:448537) + a(CONSO:"huntingtin aggregates") increases path(CONSO:neurotoxicity) - pmid:30640040 + pubmed:30027901 - p(FPLX:Actin) association a(PUBCHEM:5318517) + a(CONSO:"huntingtin aggregates") increases path(CONSO:neurotoxicity) - pmid:30640040 + pubmed:30027901 - p(HGNC:MDM4) association a(PUBCHEM:42640) + a(CONSO:"huntingtin aggregates") increases p(HGNC:HTT, pmod(CONSO:"CAG repeats")) - pmid:30640040 + pubmed:30027901 - p(HGNCGENEFAMILY:"Lysine demethylases") association a(PUBCHEM:71729974) + a(CONSO:"huntingtin aggregates") decreases composite(a(MESH:Autophagosomes), a(MESH:Lysosomes)) - pmid:30640040 + pubmed:24706768 - p(HGNC:TGFBR1) association a(PUBCHEM:4521392) + a(CONSO:"huntingtin aggregates") decreases bp(GO:"clathrin-dependent endocytosis") - pmid:30640040 + pubmed:24706768 - p(HGNC:TGFBR1) association a(PUBCHEM:447966) + a(CONSO:"huntingtin aggregates") decreases bp(GO:"clathrin-dependent endocytosis") - pmid:30640040 + pubmed:30515821 - p(HGNC:TGFBR1) association a(PUBCHEM:11655119) + p(HGNC:DNM1L) regulates bp(GO:"mitochondrial fission") - pmid:30640040 + pubmed:30515821 - p(FPLX:ROCK) association a(PUBCHEM:46209426) + act(p(HGNC:DNM1L), ma(GO:"GTPase activity")) increases bp(GO:"mitochondrial fission") + + + + + + - pmid:30640040 + pubmed:30515821 - p(HGNC:TNC) association a(PUBCHEM:3033825) + act(p(HGNC:DNM1L)) increases bp(GO:"energy homeostasis") - pmid:30640040 + pubmed:30515821 - p(HGNC:SELE) association a(PUBCHEM:9839311) + act(p(HGNC:DNM1L)) decreases a(CHEBI:"reactive oxygen species") - pmid:30640040 + pubmed:30515821 - p(HGNC:ICAM1) association a(PUBCHEM:9839311) + act(p(HGNC:DNM1L)) increases a(CHEBI:"reactive oxygen species") - pmid:30640040 + pubmed:30515821 - p(HGNC:TGFBR2) association a(PUBCHEM:11655119) + act(p(HGNC:DNM1L)) decreases path(DOID:"neurodegenerative disease") @@ -140702,13 +142360,6 @@

Statements

- - - pmid:29191965 - - composite(a(MESH:"Amyloid beta-Peptides"), a(PUBCHEM:160718443)) decreases path(MESH:Paralysis) - - @@ -140721,9 +142372,9 @@

Statements

- pmid:29191965 + pubmed:30515821 - bp(GO:"cellular response to mechanical stimulus") decreases a(GO:"microtubule cytoskeleton") + act(p(HGNC:DNM1L)) negativeCorrelation bp(GO:"ATP biosynthetic process") @@ -140732,25 +142383,13 @@

Statements

- - - pmid:29191965 - - composite(p(HGNC:MAPT), p(HGNC:SPTB)) increases a(GO:"microtubule cytoskeleton") - - - - - pmid:29191965 - - composite(p(HGNC:KLC3), p(HGNC:MAPT)) increases complex(p(HGNC:KLC3), p(HGNC:MAPT)) - + @@ -140760,791 +142399,817 @@

Statements

- pmid:29191965 + pubmed:30515821 - complex(p(HGNC:KLC3), p(HGNC:MAPT)) association a(GO:"synaptic vesicle") + act(p(HGNC:DNM1L), ma(GO:"GTPase activity")) negativeCorrelation bp(GO:"axonal transport") - pmid:29191965 + pubmed:30515821 - p(HBP:"Tau isoform E (412 aa)", var("p.Pro301Leu")) decreases bp(GO:locomotion) + act(p(HGNC:DNM1L), ma(GO:"GTPase activity")) decreases a(NCIT:C13281) - pmid:29191965 + pubmed:30515821 - p(HBP:"Tau isoform E (412 aa)", var("p.Pro301Leu")) decreases a(MESH:Survival) + act(p(HGNC:DNM1L), ma(GO:"GTPase activity")) increases bp(GO:"neuron death") + + + + + + - pmid:29191965 + pubmed:30515821 - p(HBP:"Tau isoform E (412 aa)", var("p.Pro301Leu")) increases path(HBP:Neurodegeneration) + act(p(HGNC:DNM1L)) negativeCorrelation bp(MESH:"Energy Metabolism") - pmid:29191965 + pubmed:30515821 - p(HBP:"Tau isoform E (412 aa)", var("p.Pro301Leu")) increases a(HBP:"Tau aggregates") + act(p(HGNC:DNM1L)) increases bp(NCIT:C17741) + + - pmid:29191965 + pubmed:30688256 - p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")) decreases bp(GO:locomotion) + p(HGNC:DNM1L) increases bp(GO:"brain development") - pmid:29191965 + pubmed:30688256 - p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")) decreases a(MESH:Survival) + p(HGNC:DNM1L) increases bp(GO:"synapse assembly") + + - pmid:29191965 + pubmed:30515821 - p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")) increases path(HBP:Neurodegeneration) + bp(GO:"mitochondrial fission") increases bp(GO:"programmed cell death") - pmid:29191965 + pubmed:30515821 - p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")) decreases act(a(MESH:Neurons)) + bp(GO:"mitochondrial fission") increases bp(GO:"programmed cell death") - pmid:29191965 + pubmed:30515821 - p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")) decreases act(a(MESH:Neurons)) + bp(GO:"mitochondrial fission") increases bp(GO:"programmed cell death") - pmid:29191965 + pubmed:30515821 - p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")) decreases a(GO:microtubule) + bp(GO:"mitochondrial fission") increases p(HGNC:CASP3, frag("?")) - pmid:29191965 + pubmed:30515821 - p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")) increases bp(GO:"neuron death") + bp(GO:"mitochondrial fission") increases bp(GO:"neuron differentiation") - pmid:26458742 + pubmed:30515821 - p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")) positiveCorrelation p(HBP:"Tau isoform D (383 aa)", pmod(Ph, Thr, 205)) + bp(GO:"mitochondrial fission") regulates bp(GO:neurogenesis) - pmid:26458742 + pubmed:30515821 - p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")) positiveCorrelation p(HBP:"Tau isoform D (383 aa)", pmod(Ph, Ser, 262)) + bp(GO:"mitochondrial fission") increases path(MESH:"Neuronal Plasticity") - pmid:26458742 + pubmed:30515821 - p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")) positiveCorrelation p(HBP:"Tau isoform D (383 aa)", pmod(Ph, Ser, 400)) + bp(GO:"mitochondrial fission") negativeCorrelation path(MESH:"Mitochondrial Dynamics") - pmid:26458742 + pubmed:30515821 - p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")) positiveCorrelation p(HBP:"Tau isoform D (383 aa)", pmod(Ph, Ser, 404)) + bp(GO:"mitochondrial fission") increases path(MESH:Inflammation) - pmid:26458742 + pubmed:30688256 - p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")) positiveCorrelation p(HBP:"Tau isoform D (383 aa)", pmod(Ph, Ser, 409)) + bp(GO:"mitochondrial fission") increases act(a(MESH:Neurons)) - pmid:26458742 + pubmed:30688256 - p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")) positiveCorrelation p(HBP:"Tau isoform D (383 aa)", pmod(Ph, Ser, 422)) + bp(GO:"mitochondrial fission") decreases a(MESH:Neurons) - pmid:26458742 + pubmed:30688256 - p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")) increases a(HBP:"Tau aggregates") + bp(GO:"mitochondrial fission") decreases bp(GO:mitophagy) - pmid:29191965 + pubmed:28173111 - p(HBP:"Tau isoform D (383 aa)", var("p.Arg406Trp")) decreases act(a(MESH:Neurons)) + bp(GO:"mitochondrial fission") association p(MGI:Fis1) - pmid:29191965 + pubmed:28173111 - p(HBP:"Tau isoform D (383 aa)", var("p.Arg406Trp")) decreases act(a(MESH:Neurons)) + bp(GO:"mitochondrial fission") association p(MGI:Dnm1l) - pmid:29191965 + pubmed:30515821 - p(HBP:"Tau isoform D (383 aa)", var("p.Arg406Trp")) decreases a(GO:microtubule) + path(MESH:"Mitochondrial Dynamics") regulates bp(GO:"ATP biosynthetic process") - pmid:29191965 + pubmed:30515821 - p(HBP:"Tau isoform D (383 aa)", var("p.Arg406Trp")) increases bp(GO:"neuron death") + path(MESH:"Mitochondrial Dynamics") regulates bp(GO:"calcium ion homeostasis") - pmid:29191965 + pubmed:30515821 - p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:hyperphosphorylation)) decreases bp(GO:locomotion) + path(MESH:"Mitochondrial Dynamics") regulates bp(GO:"iron ion homeostasis") - pmid:29191965 + pubmed:30515821 - p(HBP:"Tau isoform Fetal-tau (352 aa)", pmod(HBP:hyperphosphorylation)) decreases a(MESH:"Motor Neurons") + path(MESH:"Mitochondrial Dynamics") regulates bp(GO:"lipid metabolic process") - - - - - pmid:29191965 + pubmed:30515821 - composite(p(HBP:"4R tau", var("p.Lys280del")), p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met"))) increases path(MESH:Paralysis) + path(MESH:"Mitochondrial Dynamics") regulates bp(GO:"cellular amino acid metabolic process") - pmid:29191965 + pubmed:30515821 - composite(p(HBP:"4R tau", var("p.Lys280del")), p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met"))) decreases a(MESH:"GABAergic Neurons") + path(MESH:"Mitochondrial Dynamics") regulates bp(MESH:"Body Temperature Regulation") - pmid:29191965 + pubmed:30515821 - composite(p(HBP:"4R tau", var("p.Lys280del")), p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met"))) decreases a(MESH:"Cholinergic Neurons") + path(MESH:"Mitochondrial Dynamics") regulates bp(GO:"reactive oxygen species biosynthetic process") - pmid:29191965 + pubmed:30515821 - composite(p(HBP:"4R tau", var("p.Lys280del")), p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met"))) decreases a(GO:synapse) + path(MESH:"Mitochondrial Dynamics") regulates bp(GO:aging) - pmid:29191965 + pubmed:30515821 - composite(p(HBP:"4R tau", var("p.Lys280del")), p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met"))) decreases bp(GO:"axonal transport of mitochondrion") + path(MESH:"Mitochondrial Dynamics") regulates bp(GO:"programmed cell death") - pmid:25374103 + pubmed:30515821 - p(HBP:"4R tau", var("p.Lys280del")) causesNoChange bp(GO:"cell death") + path(MESH:"Mitochondrial Dynamics") regulates bp(GO:"cell population proliferation") - pmid:25374103 + pubmed:30515821 - p(HBP:"4R tau", var("p.Lys280del")) decreases bp(GO:"mitochondrion transport along microtubule") + path(MESH:"Mitochondrial Dynamics") regulates bp(GO:"cell differentiation") - pmid:25374103 + pubmed:30515821 - p(HBP:"4R tau", var("p.Lys280del")) decreases bp(GO:"mitochondrion transport along microtubule") + path(MESH:"Mitochondrial Dynamics") negativeCorrelation path(DOID:"neurodegenerative disease") - pmid:29191965 + pubmed:30515821 - p(HBP:"Tau isoform F (441 aa)", var("p.Ala152Thr")) increases path(MESH:Paralysis) + path(MESH:"Mitochondrial Dynamics") negativeCorrelation path(DOID:"breast cancer") - pmid:29191965 + pubmed:30515821 - p(HBP:"Tau isoform F (441 aa)", var("p.Ala152Thr")) decreases act(a(MESH:Neurons)) + path(MESH:"Mitochondrial Dynamics") negativeCorrelation path(DOID:"nasopharynx carcinoma") - pmid:29191965 + pubmed:30515821 - p(HBP:"Tau isoform F (441 aa)", var("p.Ala152Thr")) association bp(GO:"cell aging") + path(MESH:"Mitochondrial Dynamics") positiveCorrelation bp(GO:"axonal transport") - pmid:29191965 + pubmed:30515821 - p(HBP:"Tau isoform F (441 aa)", var("p.Ala152Thr")) decreases bp(MESH:Longevity) + path(MESH:"Mitochondrial Dynamics") positiveCorrelation bp(GO:"neurotransmitter secretion") - pmid:29191965 + pubmed:30515821 - p(HBP:"Tau isoform F (441 aa)", var("p.Ala152Thr")) decreases bp(GO:"anterograde axonal transport of mitochondrion") + path(MESH:"Mitochondrial Dynamics") positiveCorrelation bp(GO:"neurotransmitter reuptake") - pmid:29191965 + pubmed:30515821 - bp(GO:"cell aging") association p(HBP:"Tau isoform F (441 aa)", var("p.Ala152Thr")) + path(MESH:"Mitochondrial Dynamics") negativeCorrelation path(DOID:"Alzheimer's disease") - - - pmid:29191965 + pubmed:30515821 - complex(a(GO:"synaptic vesicle"), p(HGNC:MAPT)) decreases act(a(GO:"synaptic vesicle")) + path(MESH:"Mitochondrial Dynamics") negativeCorrelation path(DOID:"Parkinson's disease") - - - pmid:29191965 + pubmed:30515821 - complex(a(GO:"synaptic vesicle"), p(HGNC:MAPT)) decreases bp(MESH:"Synaptic Transmission") + path(MESH:"Mitochondrial Dynamics") negativeCorrelation composite(p(HGNC:MFN1, var("?")), p(HGNC:MFN2, var("?"))) - + + + pubmed:30515821 + + path(MESH:"Mitochondrial Dynamics") negativeCorrelation complex(a(CHEBI:amyloid-beta), p(HGNC:DNM1L)) + - pmid:29191965 + pubmed:30515821 - composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:CHRNA7)) decreases bp(GO:locomotion) + path(MESH:"Mitochondrial Dynamics") negativeCorrelation complex(p(HGNC:DNM1L), p(HGNC:PRKN, var("?"))) - + + + pubmed:30515821 + + path(MESH:"Mitochondrial Dynamics") negativeCorrelation complex(p(HGNC:DNM1L), p(HGNC:HTT, var("?"))) + - pmid:29191965 + pubmed:30515821 - composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:BAIAP3)) decreases bp(GO:locomotion) + path(MESH:"Mitochondrial Dynamics") negativeCorrelation complex(p(HGNC:DNM1L), p(HGNC:SOD1, var("?"))) - pmid:29191965 + pubmed:30515821 - p(HGNC:BAIAP3) regulates bp(GO:"retrograde trans-synaptic signaling") + path(MESH:"Mitochondrial Dynamics") negativeCorrelation bp(GO:"mitochondrial fission") - pmid:29191965 + pubmed:30515821 - a(GO:"cell body") association p(HGNC:MAPT) + path(MESH:"Mitochondrial Dynamics") negativeCorrelation p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 616)) - pmid:29191965 + pubmed:30515821 - p(HGNC:PPP3CB) directlyDecreases p(HGNC:MAPT, pmod(Ph)) + path(MESH:"Mitochondrial Dynamics") negativeCorrelation p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 616)) - pmid:26631930 + pubmed:30515821 - p(HGNC:PPP3CB) directlyDecreases p(HGNC:MAPT, pmod(Ph)) + path(MESH:"Mitochondrial Dynamics") positiveCorrelation p(HGNC:PRKN) - pmid:29191965 + pubmed:30515821 - p(HGNC:PPP1R8) directlyDecreases p(HGNC:MAPT, pmod(Ph)) + path(MESH:"Mitochondrial Dynamics") negativeCorrelation p(HGNC:DNM1) - pmid:26631930 + pubmed:30515821 - p(HGNC:PPP1R8) directlyDecreases p(HGNC:MAPT, pmod(Ph)) + path(MESH:"Mitochondrial Dynamics") negativeCorrelation p(HGNC:DNM1) - + + + pubmed:30515821 + + path(MESH:"Mitochondrial Dynamics") negativeCorrelation p(HGNC:DNM1, pmod(go:0017014 ! "protein nitrosylation", Cys, 644)) + - pmid:29191965 + pubmed:30515821 - composite(p(HBP:"Tau isoform D (383 aa)", var("p.Arg406Trp")), p(HGNC:CDK5)) decreases a(MESH:Neurons) + path(MESH:"Mitochondrial Dynamics") negativeCorrelation a(CHEBI:"reactive oxygen species") - pmid:29191965 + pubmed:30515821 - a(PUBCHEM:6475963) decreases a(HBP:"Tau aggregates") + path(MESH:"Mitochondrial Dynamics") negativeCorrelation bp(GO:"negative regulation of mitophagy") - pmid:29191965 + pubmed:30515821 - a(PUBCHEM:6475963) increases bp(GO:locomotion) + path(MESH:"Mitochondrial Dynamics") negativeCorrelation composite(a(CHEBI:amyloid-beta), p(HGNC:DNM1)) - pmid:29191965 + pubmed:30515821 - a(PUBCHEM:66766582) decreases path(HBP:Neurodegeneration) + path(MESH:"Mitochondrial Dynamics") negativeCorrelation composite(p(HGNC:DNM1), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) - pmid:29191965 + pubmed:30515821 - a(CHEBI:azaperone) increases bp(GO:locomotion) + path(MESH:"Mitochondrial Dynamics") positiveCorrelation act(a(GO:synapse)) - pmid:29191965 + pubmed:30515821 - a(CHEBI:azaperone) decreases p(HGNC:MAPT) + path(MESH:"Mitochondrial Dynamics") negativeCorrelation path(MESH:"Wounds and Injuries") - pmid:29191965 + pubmed:30515821 - a(CHEBI:azaperone) decreases path(HBP:Neurodegeneration) + path(MESH:"Mitochondrial Dynamics") increases bp(GO:memory) - pmid:29191965 + pubmed:30515821 - a(CHEBI:ethosuximide) increases bp(MESH:Longevity) + path(MESH:"Mitochondrial Dynamics") increases bp(GO:cognition) - pmid:29191965 + pubmed:30515821 - a(CHEBI:ethosuximide) increases bp(GO:locomotion) + path(MESH:"Mitochondrial Dynamics") positiveCorrelation p(HGNC:PINK1) - pmid:29191965 + pubmed:30515821 - a(CHEBI:ethosuximide) association bp(GO:"insulin receptor signaling pathway") + path(MESH:"Mitochondrial Dynamics") negativeCorrelation p(HGNC:PINK1, var("p.Try437?")) - pmid:29191965 + pubmed:30515821 - p(HGNC:WNT2) association path(MESH:Tauopathies) + path(MESH:"Mitochondrial Dynamics") negativeCorrelation p(HGNC:PINK1, var("p.Lys219Met")) - pmid:29191965 + pubmed:30515821 - p(HGNC:TTBK2) association path(MESH:Tauopathies) + path(MESH:"Mitochondrial Dynamics") negativeCorrelation complex(p(HGNC:DNM1L), p(HGNC:HTT, pmod(CONSO:"CAG repeats"))) - pmid:17620722 + pubmed:30515821 - p(HGNC:TTBK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 208)) + path(MESH:"Mitochondrial Dynamics") positiveCorrelation complex(p(HGNC:DNM1L, var("p.Lys38Ala")), p(HGNC:HTT, pmod(CONSO:"CAG repeats"))) - pmid:17620722 + pubmed:30515821 - p(HGNC:TTBK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 210)) + path(MESH:"Mitochondrial Dynamics") positiveCorrelation p(HGNC:DNM1L, var("p.Cys644Ala")) - - - + + + pubmed:30515821 + + path(MESH:"Mitochondrial Dynamics") association p(HGNC:MAPK1) + - pmid:25673844 + pubmed:30515821 - p(HGNC:TTBK2) isA p(HBP:"CK1 superfamily") + path(MESH:"Mitochondrial Dynamics") positiveCorrelation a(CHEBI:U0126) - pmid:25673844 + pubmed:30515821 - p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Ser, 42)) + path(MESH:"Mitochondrial Dynamics") positiveCorrelation p(HGNC:DNM1L, var("p.Ser616Ala")) - pmid:25673844 + pubmed:30515821 - p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Ser, 45)) + path(MESH:"Mitochondrial Dynamics") negativeCorrelation path(DOID:"amyotrophic lateral sclerosis") - pmid:25673844 + pubmed:21861815 - p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Ser, 47)) + path(MESH:"Mitochondrial Dynamics") negativeCorrelation p(HGNC:HTT, pmod(CONSO:"CAG repeats")) - pmid:25673844 + pubmed:27190210 - p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Ser, 80)) + bp(GO:"cell differentiation") association p(HGNC:CHRNA7) - pmid:25673844 + pubmed:28901280 - p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Ser, 81)) + bp(GO:"cell differentiation") association p(MESH:"Receptors, Nicotinic") - pmid:25673844 + pubmed:30515821 - p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(Ph, Thr, 84)) + path(DOID:"breast cancer") negativeCorrelation path(MESH:"Mitochondrial Dynamics") - pmid:25473830 + pubmed:30515821 - p(HGNC:TTBK2) directlyIncreases p(HGNC:TARDBP, pmod(Ph)) + path(DOID:"nasopharynx carcinoma") negativeCorrelation path(MESH:"Mitochondrial Dynamics") - pmid:25473830 + pubmed:30515821 - p(HGNC:TTBK2) increases tloc(p(HGNC:TARDBP, pmod(Ph)), fromLoc(GO:nucleus), toLoc(GO:cytoplasm)) + bp(GO:"neurotransmitter secretion") positiveCorrelation path(MESH:"Mitochondrial Dynamics") - pmid:27607061 + pubmed:28445721 - p(HGNC:TTBK2) decreases surf(p(HGNC:GRIK2)) + bp(GO:"neurotransmitter secretion") regulates p(FPLX:CHRN) - pmid:23942339 + pubmed:18986241 - p(HGNC:TTBK2) increases act(p(HGNC:SLC6A12)) + bp(GO:"neurotransmitter secretion") association p(HGNCGENEFAMILY:Synaptotagmins) - pmid:22814243 + pubmed:18986241 - p(HGNC:TTBK2) increases act(p(HGNC:SLC5A1)) + bp(GO:"neurotransmitter secretion") association p(HGNC:NGF) - pmid:25297623 + pubmed:21787755 - p(HGNC:TTBK2) association p(HGNC:CEP164) + bp(GO:"neurotransmitter secretion") association p(CONSO:"alpha-7-containing nAChR") - pmid:25297623 + pubmed:30515821 - p(HGNC:TTBK2) association p(HGNC:MAPRE1) + bp(GO:"neurotransmitter reuptake") positiveCorrelation path(MESH:"Mitochondrial Dynamics") - pmid:25297623 + pubmed:30515821 - act(p(HGNC:TTBK2)) increases deg(p(HGNC:CCP110)) + p(HGNC:MFN1, loc(GO:"mitochondrial outer membrane")) regulates bp(GO:"mitochondrial fusion") - pmid:25297623 + pubmed:30688256 - act(p(HGNC:TTBK2)) increases p(HGNC:CEP164, pmod(Ph)) + p(HGNC:MFN1) increases bp(GO:"mitochondrial fusion") + + + + + + - pmid:25297623 + pubmed:30688256 - act(p(HGNC:TTBK2)) increases p(HGNC:CEP97, pmod(Ph)) + bp(GO:"mitochondrial fusion") decreases bp(GO:mitophagy) - pmid:25297623 + pubmed:28173111 - act(p(HGNC:TTBK2)) increases bp(GO:"cytosolic ciliogenesis") + bp(GO:"mitochondrial fusion") association p(MGI:Mfn1) - pmid:29191965 + pubmed:28173111 - p(HGNC:TAOK1) association path(MESH:Tauopathies) + bp(GO:"mitochondrial fusion") association p(MGI:Mfn2) - pmid:25974414 + pubmed:28173111 - act(p(HGNC:TAOK1), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + bp(GO:"mitochondrial fusion") association p(MGI:Opa1) - pmid:29191965 + pubmed:30515821 - p(HGNC:CTSE) association path(MESH:Tauopathies) + p(HGNC:MFN2, loc(GO:"mitochondrial outer membrane")) regulates bp(GO:"mitochondrial fusion") - pmid:29191965 + pubmed:30688256 - p(HGNC:DNMBP) increases complex(p(HGNC:DNMBP), p(HGNC:ENAH)) + p(HGNC:MFN2) increases bp(GO:"mitochondrial fusion") @@ -141555,2771 +143220,2889 @@

Statements

+ + + pubmed:30837838 + + p(HGNC:MFN2) increases path(MESH:"Mitochondrial Size") + + - pmid:29191965 + pubmed:30837838 - composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:DNMBP)) increases path(MESH:Tauopathies) + p(HGNC:MFN2) increases path(MESH:Movement) - pmid:29191965 + pubmed:30515821 - p(HGNC:ZC3H14) decreases bp(GO:locomotion) + p(HGNC:OPA1, loc(GO:"mitochondrial inner membrane")) regulates bp(GO:"mitochondrial fusion") - pmid:29191965 + pubmed:30515821 - p(HGNC:ZC3H14) increases path(HBP:Neurodegeneration) + p(HGNC:OPA1) regulates bp(GO:"mitochondrial inner membrane fusion") - pmid:29191965 + pubmed:30515821 - p(HGNC:ZC3H14) increases p(HGNC:MAPT) + p(HGNC:OPA1) regulates bp(GO:"mitochondrial genome maintenance") - pmid:29191965 + pubmed:30515821 - p(HGNC:ZC3H14) increases path(MESH:Tauopathies) + p(HGNC:OPA1) regulates bp(GO:"cristae formation") + + - pmid:29191965 + pubmed:30515821 - p(HGNC:ZC3H14) regulates bp(GO:"aggresome assembly") + composite(p(HGNC:MFN1), p(HGNC:MFN2)) regulates bp(GO:"mitochondrial outer membrane fusion") - pmid:29191965 + pubmed:30515821 - bp(GO:"aggresome assembly") association path(MESH:"Neurodegenerative Diseases") + composite(p(HGNC:MFN1, var("?")), p(HGNC:MFN2, var("?"))) negativeCorrelation path(MESH:"Mitochondrial Dynamics") - pmid:29191965 + pubmed:30515821 - bp(GO:"aggresome assembly") decreases p(MESH:Proteins, pmod(HBP:misfolding)) + composite(p(HGNC:MFN1, var("?")), p(HGNC:MFN2, var("?"))) negativeCorrelation bp(GO:"embryo development") + + + + - pmid:29191965 + pubmed:30515821 - p(HGNC:DDC) increases a(CHEBI:dopamine) + bp(GO:"embryo development") negativeCorrelation composite(p(HGNC:MFN1, var("?")), p(HGNC:MFN2, var("?"))) - pmid:29191965 + pubmed:29311797 - p(HGNC:DDC) increases a(CHEBI:serotonin) + bp(GO:"embryo development") association p(HGNC:HSP90AB1) - + + + pubmed:30515821 + + p(HGNC:OPA1, var("?")) increases path(DOID:"optic atrophy") + - pmid:29191965 + pubmed:30515821 - composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:DDC)) decreases bp(GO:locomotion) + p(HGNC:MIEF2, loc(GO:"mitochondrial outer membrane")) increases tloc(p(HGNC:DNM1L), fromLoc(GO:cytosol), toLoc(GO:"mitochondrial outer membrane")) + + - pmid:29191965 + pubmed:30515821 - composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:DDC)) increases p(HGNC:MAPT) + act(p(HGNC:MIEF2)) increases bp(GO:"energy homeostasis") - pmid:29191965 + pubmed:30515821 - composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:DDC)) increases p(HGNC:MAPT, pmod(Ph)) + act(p(HGNC:MIEF2)) decreases a(CHEBI:"reactive oxygen species") - pmid:29191965 + pubmed:30515821 - composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:DDC)) increases path(HBP:Neurodegeneration) + act(p(HGNC:MIEF2)) decreases path(DOID:"neurodegenerative disease") + + + pubmed:30515821 + + p(HGNC:MIEF1, loc(GO:"mitochondrial outer membrane")) increases tloc(p(HGNC:DNM1L), fromLoc(GO:cytosol), toLoc(GO:"mitochondrial outer membrane")) + + - pmid:29191965 + pubmed:30515821 - composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:TH)) causesNoChange path(MESH:Tauopathies) + act(p(HGNC:MIEF1)) increases bp(GO:"energy homeostasis") - pmid:29191965 + pubmed:30515821 - p(HGNC:GCH1) regulates a(CHEBI:dopamine) + act(p(HGNC:MIEF1)) decreases a(CHEBI:"reactive oxygen species") - pmid:29191965 + pubmed:30515821 - p(HGNC:GCH1) regulates a(CHEBI:serotonin) + act(p(HGNC:MIEF1)) decreases path(DOID:"neurodegenerative disease") - pmid:29191965 + pubmed:30515821 - p(HGNC:GCH1) regulates act(p(HGNC:DDC)) + p(HGNC:MFF, loc(GO:"mitochondrial outer membrane")) increases tloc(p(HGNC:DNM1L), fromLoc(GO:cytosol), toLoc(GO:"mitochondrial outer membrane")) - - - - - pmid:29191965 + pubmed:30515821 - composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:GCH1)) causesNoChange path(MESH:Tauopathies) + act(p(HGNC:MFF)) increases bp(GO:"energy homeostasis") - pmid:29191965 + pubmed:30515821 - p(HGNC:TPH1) regulates a(CHEBI:dopamine) + act(p(HGNC:MFF)) decreases a(CHEBI:"reactive oxygen species") - pmid:29191965 + pubmed:30515821 - p(HGNC:TPH1) regulates a(CHEBI:serotonin) + act(p(HGNC:MFF)) decreases path(DOID:"neurodegenerative disease") - pmid:29191965 + pubmed:30515821 - p(HGNC:TPH1) regulates act(p(HGNC:DDC)) + p(HGNC:FIS1, loc(GO:"mitochondrial outer membrane")) increases tloc(p(HGNC:DNM1L), fromLoc(GO:cytosol), toLoc(GO:"mitochondrial outer membrane")) - - - pmid:29191965 + pubmed:30515821 - composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:TPH1)) causesNoChange path(MESH:Tauopathies) + act(p(HGNC:FIS1)) increases bp(GO:"energy homeostasis") - pmid:29686391 + pubmed:30515821 - a(HBP:"sonicated tau fibrils") positiveCorrelation tloc(a(HBP:"sonicated tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + act(p(HGNC:FIS1)) decreases a(CHEBI:"reactive oxygen species") - pmid:29686391 + pubmed:30515821 - tloc(a(HBP:"sonicated tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) positiveCorrelation a(HBP:"sonicated tau fibrils") + act(p(HGNC:FIS1)) decreases path(DOID:"neurodegenerative disease") - pmid:29686391 + pubmed:30515821 - g(HGNC:TP53) increases bp(GO:"mitotic G1 phase") + complex(p(HGNC:DNM1L), p(HGNC:MIEF2), loc(GO:"mitochondrial outer membrane")) increases bp(GO:"mitochondrial fission") - pmid:29686391 + pubmed:30515821 - g(HGNC:TP53) decreases bp(GO:"cell proliferation") + complex(p(HGNC:DNM1L), p(HGNC:MIEF1), loc(GO:"mitochondrial outer membrane")) increases bp(GO:"mitochondrial fission") - pmid:29686391 + pubmed:30515821 - bp(GO:"mitotic G1 phase") positiveCorrelation bp(GO:endocytosis) + complex(p(HGNC:DNM1L), p(HGNC:FIS1), loc(GO:"mitochondrial outer membrane")) increases bp(GO:"mitochondrial fission") - pmid:29686391 + pubmed:30515821 - bp(GO:"mitotic G1 phase") regulates tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + complex(p(HGNC:DNM1L), p(HGNC:FIS1)) increases bp(GO:"mitochondrial fission") - pmid:29686391 + pubmed:30515821 - p(HGNC:CDK6) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + complex(p(HGNC:DNM1L), p(HGNC:FIS1)) increases r(HGNC:AKAP1) - pmid:29686391 + pubmed:30515821 - a(CHEBI:palbociclib) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + complex(a(CHEBI:amyloid-beta), p(HGNC:DNM1L)) negativeCorrelation path(MESH:"Mitochondrial Dynamics") - pmid:29686391 + pubmed:30515821 - a(CHEBI:palbociclib) decreases act(p(HGNC:CDK4)) + complex(p(HGNC:DNM1L), p(HGNC:PRKN, var("?"))) negativeCorrelation path(MESH:"Mitochondrial Dynamics") + + - pmid:29686391 + pubmed:30515821 - a(CHEBI:palbociclib) decreases act(p(HGNC:CDK6)) + p(HGNC:PRKN, var("?")) directlyIncreases bp(GO:"mitochondrial fission") - pmid:29686391 + pubmed:30688256 - p(HGNC:EXT2) association bp(GO:"heparan sulfate proteoglycan biosynthetic process") + p(HGNC:PRKN, var("?")) increases path(MESH:"Parkinson Disease") - pmid:29686391 + pubmed:30116051 - p(HGNC:EXT2) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(HGNC:PRKN, var("?")) association path(MESH:"Parkinson Disease") - pmid:29686391 + pubmed:30688256 - p(HGNC:EXT2) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(HGNC:PRKN, var("?")) decreases bp(GO:mitophagy) - pmid:29686391 + pubmed:30116051 - p(HGNC:EXT2) increases tloc(a(HBP:"Tau oligomers"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(HGNC:PRKN, var("?")) decreases bp(GO:mitophagy) - pmid:29686391 + pubmed:30688256 - bp(GO:"heparan sulfate proteoglycan biosynthetic process") association p(HGNC:EXT2) + p(HGNC:PRKN, var("?")) increases path(HBP:"mitochondrial dysfunction") - pmid:29686391 + pubmed:30688256 - bp(GO:"heparan sulfate proteoglycan biosynthetic process") association p(HGNC:HS6ST1) + p(HGNC:PRKN, var("?")) increases path(MESH:"Neurodegenerative Diseases") - pmid:29686391 + pubmed:28803412 - p(HGNC:HS6ST1) association bp(GO:"heparan sulfate proteoglycan biosynthetic process") + p(HGNC:PRKN, var("?")) increases path(MESH:"Neurodegenerative Diseases") - pmid:29686391 + pubmed:21722302 - p(HGNC:HS6ST1) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(HGNC:PRKN, var("?")) increases bp(GO:"negative regulation of ubiquitin protein ligase activity") - pmid:29686391 + pubmed:21722302 - p(HGNC:HS6ST1) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(HGNC:PRKN, var("?")) increases bp(MESH:"Cell Death") - pmid:29686391 + pubmed:21722302 - p(HGNC:HS6ST1) increases tloc(a(HBP:"Tau oligomers"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(HGNC:PRKN, var("?")) decreases bp(GO:"parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization") - pmid:29686391 + pubmed:14556719 - p(HGNC:HS6ST1) increases a(HBP:"6-O-sulfated heparin") + p(HGNC:PRKN, var("?")) increases path(MESH:"Parkinsonian Disorders") - pmid:29686391 + pubmed:14556719 - p(HGNC:DNM2) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(HGNC:PRKN, var("?")) decreases act(p(HGNC:PRKN)) - pmid:29686391 + pubmed:14556719 - p(HGNC:DNM2) increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(HGNC:PRKN, var("?")) increases p(HGNC:PRKN) - pmid:29686391 + pubmed:14556719 - p(HGNC:DNM2) increases tloc(a(HBP:"Tau oligomers"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(HGNC:PRKN, var("?")) decreases act(p(HGNC:SEPT5)) - pmid:29686391 + pubmed:14556719 - a(HBP:"6-O-sulfated heparin") positiveCorrelation complex(a(HBP:"6-O-sulfated heparin"), a(HBP:"Tau isoform F (441 aa)")) + p(HGNC:PRKN, var("?")) causesNoChange deg(p(HGNC:SNCA)) - pmid:29686391 + pubmed:30116051 - a(HBP:"6-O-sulfated heparin") increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(HGNC:PRKN, var("?")) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") - pmid:29686391 + pubmed:30515821 - a(HBP:"6-O-sulfated heparin") association tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + complex(p(HGNC:DNM1L), p(HGNC:HTT, var("?"))) negativeCorrelation path(MESH:"Mitochondrial Dynamics") - pmid:29686391 + pubmed:30515821 - a(HBP:"6-O-sulfated heparin") increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + complex(p(HGNC:DNM1L), p(HGNC:SOD1, var("?"))) negativeCorrelation path(MESH:"Mitochondrial Dynamics") - pmid:29980653 + pubmed:30515821 - a(HBP:"6-O-sulfated heparin") increases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 40), pmod(go:0006468 ! "protein phosphorylation", Ser, 44)) increases act(p(HGNC:DNM1L), ma(GO:"GTPase activity")) - - - - - + + + pubmed:30515821 + + bp(GO:"response to amyloid-beta") increases path(MESH:"Neurotoxicity Syndromes") + - pmid:29686391 + pubmed:30515821 - a(MESH:"Heparitin Sulfate") decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 579)) increases bp(GO:"mitochondrial fission") - - - pmid:29686391 + pubmed:30515821 - complex(a(HBP:"6-O-sulfated heparin"), a(HBP:"Tau isoform F (441 aa)")) positiveCorrelation a(HBP:"6-O-sulfated heparin") + p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 579)) increases p(HGNC:CASP3, frag("?")) - - - pmid:29686391 + pubmed:30515821 - a(HBP:"2-O-sulfated heparin") increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 579)) increases bp(GO:"programmed cell death") - pmid:29686391 + pubmed:30515821 - a(HBP:"2-O-sulfated heparin") increases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 579)) regulates path(MESH:"Mitochondrial Dynamics") - pmid:29686391 + pubmed:30515821 - a(CHEBI:"chondroitin sulfate") decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(HGNC:CASP3, frag("?")) increases bp(GO:"programmed cell death") - pmid:29686391 + pubmed:30515821 - a(CHEBI:"chondroitin sulfate") causesNoChange tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + a(CHEBI:seliciclib) decreases p(HGNC:CDK5) - pmid:29686391 + pubmed:30515821 - p(HGNC:SULF1) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + a(CHEBI:seliciclib) decreases p(HGNC:CASP3, frag("?")) - pmid:29686391 + pubmed:30515821 - p(HGNC:SULF1) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + a(CHEBI:seliciclib) decreases bp(GO:"programmed cell death") - pmid:29686391 + pubmed:30515821 - p(HGNC:SULF1) decreases a(HBP:"6-O-sulfated heparin") + a(CHEBI:seliciclib) decreases path(MESH:"Wounds and Injuries") - pmid:29686391 + pubmed:30515821 - p(HGNC:SULF2) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 585)) increases act(p(HGNC:DNM1L)) - pmid:29686391 + pubmed:30515821 - p(HGNC:SULF2) decreases tloc(a(HBP:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 585)) regulates path(MESH:"Mitochondrial Dynamics") - pmid:29686391 + pubmed:30515821 - p(HGNC:SULF2) decreases a(HBP:"6-O-sulfated heparin") + bp(GO:"regulation of NMDA receptor activity") positiveCorrelation a(CHEBI:"reactive oxygen species") - pmid:30985105 + pubmed:30515821 - p(HGNC:OGT) increases p(MESH:Proteins, pmod(HBP:"O-GlcNAcylation")) + bp(GO:"regulation of NMDA receptor activity") increases path(MESH:"Wounds and Injuries") - pmid:30985105 + pubmed:30515821 - p(HGNC:OGT) increases p(MESH:Proteins, pmod(HBP:"O-GlcNAcylation")) + p(HGNC:NES) increases bp(GO:"central nervous system development") - pmid:30985105 + pubmed:30515821 - p(HGNC:OGT) association bp(GO:"brain development") + p(HGNC:NES) regulates bp(GO:neurogenesis) - pmid:30985105 + pubmed:30515821 - act(p(HGNC:OGT)) decreases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:NES) decreases act(p(HGNC:CDK5, loc(GO:cytosol))) - pmid:30985105 + pubmed:30515821 - act(p(HGNC:OGT)) decreases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:NES) increases p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 592)) - pmid:30985105 + pubmed:30515821 - act(p(HGNC:OGT)) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 592)) increases bp(GO:"mitochondrial fission") - pmid:30985105 + pubmed:30515821 - act(p(HGNC:OGT)) increases p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) + p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 592)) increases bp(MESH:Glycolysis) - pmid:30985105 + pubmed:30515821 - act(p(HGNC:OGT)) decreases a(HBP:"Tau aggregates") + p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 592)) increases bp(GO:"neuron differentiation") - pmid:30985105 + pubmed:30515821 - p(MESH:Proteins, pmod(HBP:"O-GlcNAcylation")) association bp(GO:"cellular glucose homeostasis") + p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 592)) regulates bp(GO:neurogenesis) - pmid:30985105 + pubmed:30515821 - p(MESH:Proteins, pmod(HBP:"O-GlcNAcylation")) positiveCorrelation a(CHEBI:glucose) + p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 592)) regulates path(MESH:"Mitochondrial Dynamics") - pmid:30985105 + pubmed:30515821 - p(MESH:Proteins, pmod(HBP:"O-GlcNAcylation")) negativeCorrelation act(p(HGNC:OGA)) + p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 616)) association path(MESH:"Wounds and Injuries") - pmid:30985105 + pubmed:30515821 - p(MESH:Proteins, pmod(HBP:"O-GlcNAcylation")) association bp(GO:"protein phosphorylation") + p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 616)) increases path(MESH:"Neuronal Plasticity") - pmid:30985105 + pubmed:30515821 - p(MESH:Proteins, pmod(HBP:"O-GlcNAcylation")) association bp(GO:"protein phosphorylation") + p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 616)) negativeCorrelation path(MESH:"Mitochondrial Dynamics") - pmid:30985105 + pubmed:30515821 - p(MESH:Proteins, pmod(HBP:"O-GlcNAcylation")) association bp(GO:"glucose metabolic process") + p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 616)) regulates path(MESH:"Mitochondrial Dynamics") - pmid:30985105 + pubmed:30515821 - p(MESH:Proteins, pmod(HBP:"O-GlcNAcylation")) negativeCorrelation deg(a(GO:"neurofibrillary tangle")) + p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 616)) negativeCorrelation path(MESH:"Mitochondrial Dynamics") - pmid:19732809 + pubmed:30515821 - p(MESH:Proteins, pmod(HBP:"O-GlcNAcylation")) negativeCorrelation path(MESH:"Cardiovascular Diseases") + p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 616)) increases path(DOID:"Huntington's disease") - pmid:19732809 + pubmed:30515821 - p(MESH:Proteins, pmod(HBP:"O-GlcNAcylation")) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 616)) directlyIncreases act(p(HGNC:DNM1L)) - pmid:19732809 + pubmed:30515821 - p(MESH:Proteins, pmod(HBP:"O-GlcNAcylation")) negativeCorrelation path(MESH:"Diabetes Mellitus, Type 2") + a(PUBCHEM:4124851) decreases p(HGNC:GSK3B) - pmid:19732809 + pubmed:30515821 - p(MESH:Proteins, pmod(HBP:"O-GlcNAcylation")) association bp(MESH:"Hot Temperature") + a(PUBCHEM:4124851) decreases path(MESH:"Neuronal Plasticity") - pmid:19732809 + pubmed:30515821 - p(MESH:Proteins, pmod(HBP:"O-GlcNAcylation")) decreases act(complex(GO:"proteasome complex")) + a(PUBCHEM:4124851) regulates path(MESH:"Mitochondrial Dynamics") - pmid:30985105 + pubmed:30515821 - p(HGNC:OGA) increases p(MESH:Proteins, pmod(HBP:"O-GlcNAcylation")) + a(CHEBI:U0126) decreases p(HGNC:MAP2K1) - pmid:30985105 + pubmed:23393546 - act(p(HGNC:OGA)) negativeCorrelation p(MESH:Proteins, pmod(HBP:"O-GlcNAcylation")) + a(CHEBI:U0126) decreases p(HGNC:MAP2K1) - pmid:30985105 + pubmed:30515821 - act(p(HGNC:OGA)) decreases p(HGNC:MTOR, pmod(Ph)) + a(CHEBI:U0126) decreases p(HGNC:MAP2K2) - pmid:30985105 + pubmed:23393546 - act(p(HGNC:OGA)) decreases p(FPLX:AKT, pmod(Ph)) + a(CHEBI:U0126) decreases p(HGNC:MAP2K2) - pmid:30985105 + pubmed:30515821 - act(p(HGNC:OGA)) decreases bp(GO:autophagy) + a(CHEBI:U0126) decreases path(DOID:"Huntington's disease") - pmid:30985105 + pubmed:30515821 - act(p(HGNC:OGA)) decreases p(HGNC:HTT, var("?")) + a(CHEBI:U0126) regulates path(MESH:"Mitochondrial Dynamics") - pmid:30985105 + pubmed:30515821 - bp(GO:"cellular glucose homeostasis") association p(MESH:Proteins, pmod(HBP:"O-GlcNAcylation")) + a(CHEBI:U0126) positiveCorrelation path(MESH:"Mitochondrial Dynamics") - pmid:30985105 + pubmed:30515821 - path(MESH:Hyperglycemia) increases p(MESH:Proteins, pmod(HBP:"O-GlcNAcylation")) + a(CHEBI:U0126) decreases a(CHEBI:"reactive oxygen species") - pmid:30985105 + pubmed:30515821 - a(PUBCHEM:9576811) decreases act(p(HGNC:OGA)) + a(CHEBI:U0126) regulates bp(GO:"mitochondrial depolarization") - pmid:30985105 + pubmed:23393546 - a(PUBCHEM:9576811) decreases act(p(HGNC:OGA)) + a(CHEBI:U0126) decreases p(HGNC:MAPK3, pmod(go:0006468 ! "protein phosphorylation")) - pmid:30985105 + pubmed:23393546 - a(PUBCHEM:9576811) decreases act(a(MESH:Hexosaminidases)) + a(CHEBI:U0126) decreases p(HGNC:MAPK1, pmod(go:0006468 ! "protein phosphorylation")) + + - pmid:30985105 + pubmed:30515821 - a(PUBCHEM:9576811) increases p(HGNC:APP, pmod(HBP:"O-GlcNAcylation")) + p(HGNC:DNM1L, var("p.Ser616Ala")) decreases path(DOID:"Huntington's disease") - pmid:30985105 + pubmed:30515821 - a(PUBCHEM:9576811) increases p(HGNC:APP, pmod(HBP:"O-GlcNAcylation")) + p(HGNC:DNM1L, var("p.Ser616Ala")) regulates path(MESH:"Mitochondrial Dynamics") - pmid:30985105 + pubmed:30515821 - a(PUBCHEM:9576811) increases sec(p(HBP:"sAPP-alpha")) + p(HGNC:DNM1L, var("p.Ser616Ala")) positiveCorrelation path(MESH:"Mitochondrial Dynamics") - pmid:30985105 + pubmed:30515821 - a(PUBCHEM:9576811) decreases sec(a(CHEBI:"amyloid-beta polypeptide 40")) + p(HGNC:DNM1L, var("p.Ser616Ala")) increases a(CHEBI:"reactive oxygen species") - pmid:30985105 + pubmed:30515821 - a(PUBCHEM:9576811) increases tloc(p(HGNC:APP), fromLoc(GO:"trans-Golgi network"), toLoc(GO:"plasma membrane")) + path(DOID:"brain ischemia") increases p(HGNC:AKAP1, loc(GO:mitochondrion)) - pmid:30985105 + pubmed:30515821 - a(PUBCHEM:9576811) decreases tloc(p(HGNC:APP), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + p(HGNC:AKAP1, loc(GO:mitochondrion)) decreases bp(GO:"mitochondrial fission") - pmid:30985105 + pubmed:30515821 - a(PUBCHEM:9576811) increases bp(HBP:"APP processing") + p(HGNC:AKAP1, loc(GO:mitochondrion)) decreases a(CHEBI:"reactive oxygen species") - pmid:30985105 + pubmed:30515821 - a(PUBCHEM:135566354) decreases act(p(HGNC:OGA)) + p(HGNC:AKAP1, loc(GO:mitochondrion)) regulates bp(GO:"calcium ion homeostasis") - pmid:30985105 + pubmed:30515821 - a(PUBCHEM:135566354) decreases act(p(HGNC:OGA)) + p(HGNC:AKAP1) decreases p(HGNC:DNM1L, loc(GO:mitochondrion)) - pmid:30985105 + pubmed:30515821 - a(PUBCHEM:135566354) increases p(HGNC:SNCA) + p(HGNC:AKAP1) increases p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 637)) - pmid:30985105 + pubmed:30515821 - a(PUBCHEM:135566354) decreases p(HGNC:MAPT, pmod(Ph, Thr, 231)) + p(HGNC:AKAP1) increases path(MESH:Neuroprotection) + + - pmid:30985105 + pubmed:30515821 - a(PUBCHEM:135566354) decreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 637)) increases path(MESH:Neuroprotection) - pmid:30985105 + pubmed:30515821 - a(PUBCHEM:135566354) decreases a(HBP:"Tau aggregates") + p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 637)) decreases complex(GO:"calcium- and calmodulin-dependent protein kinase complex") - pmid:30985105 + pubmed:30515821 - a(PUBCHEM:135566354) decreases a(HBP:"Tau aggregates") + p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 637)) decreases bp(GO:"necroptotic process") - pmid:30985105 + pubmed:30515821 - a(PUBCHEM:135566354) decreases a(HBP:"Tau aggregates") + p(HGNC:SIAH2) decreases r(FPLX:PKA) - pmid:30985105 + pubmed:30515821 - a(PUBCHEM:135566354) decreases a(HBP:"Tau aggregates", loc(MESH:Brain)) + p(HGNC:SIAH2) decreases complex(p(HGNC:DNM1L), p(HGNC:FIS1)) - pmid:30985105 + pubmed:30515821 - a(PUBCHEM:135566354) decreases p(RGD:Mapt, pmod(Ph, Thr, 231)) + p(HGNC:SIAH2) decreases r(HGNC:AKAP1) - pmid:30985105 + pubmed:30515821 - a(PUBCHEM:135566354) decreases p(RGD:Mapt, pmod(Ph, Ser, 396)) + r(FPLX:PKA) increases r(HGNC:AKAP1) - pmid:30985105 + pubmed:30515821 - a(PUBCHEM:135566354) decreases p(RGD:Mapt, pmod(Ph, Ser, 422)) + a(CHEBI:"L-glutamate(1-)") decreases p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 637)) - pmid:30985105 + pubmed:30515821 - a(PUBCHEM:135566354) increases p(MGI:Mapt, pmod(HBP:"O-GlcNAcylation")) + p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 40)) regulates path(MESH:"Mitochondrial Dynamics") - pmid:30985105 + pubmed:30515821 - a(PUBCHEM:135566354) increases p(MGI:Mapt, pmod(HBP:"O-GlcNAcylation")) + p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 44)) regulates path(MESH:"Mitochondrial Dynamics") - pmid:30985105 + pubmed:30515821 - a(PUBCHEM:135566354) decreases bp(GO:"neuron death") + p(FPLX:PKA) increases p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 656)) + + - pmid:30985105 + pubmed:26813123 - a(PUBCHEM:135566354) decreases p(MGI:Mapt, pmod(Ph, Ser, 202), pmod(Ph, Ser, 205)) + p(FPLX:PKA) increases p(FPLX:CHRN, pmod(go:0006468 ! "protein phosphorylation")) - pmid:30985105 + pubmed:24653673 - a(PUBCHEM:135566354) decreases p(MGI:Mapt, pmod(Ph, Ser, 626)) + p(FPLX:PKA) increases p(HGNC:PPP2R5A, pmod(go:0006468 ! "protein phosphorylation", Ser)) - pmid:30985105 + pubmed:24653673 - a(PUBCHEM:135566354) decreases p(MGI:Mapt, pmod(Ph, Ser, 356)) + p(FPLX:PKA) increases p(HGNC:PPP2R5D, pmod(go:0006468 ! "protein phosphorylation", Ser)) - pmid:30985105 + pubmed:12428809 - a(PUBCHEM:135566354) decreases p(MGI:Mapt, pmod(Ph, Ser, 396)) + p(FPLX:PKA) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:30985105 + pubmed:29191965 - a(PUBCHEM:135566354) causesNoChange p(MGI:Mapt, pmod(Ph, Ser, 400)) + p(FPLX:PKA) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:30985105 + pubmed:26195256 - a(PUBCHEM:135566354) decreases p(HGNC:MAPT, loc(MESH:"Cerebrospinal Fluid")) + p(FPLX:PKA) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:30985105 + pubmed:26631930 - a(PUBCHEM:135566354) increases bp(GO:cognition) + p(FPLX:PKA) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + - pmid:30985105 + pubmed:22908190 - a(PUBCHEM:135566354) decreases a(CHEBI:"amyloid-beta") + act(p(FPLX:PKA)) increases p(HGNC:UCHL1) - pmid:30985105 + pubmed:30116051 - a(PUBCHEM:135566354) causesNoChange p(MGI:Mapt, pmod(Ph)) + act(p(FPLX:PKA), ma(go:0016301 ! "kinase activity")) increases p(HGNC:PSMC5, pmod(go:0006468 ! "protein phosphorylation", Ser, 120)) - pmid:30985105 + pubmed:25331948 - bp(GO:"protein phosphorylation") association p(MESH:Proteins, pmod(HBP:"O-GlcNAcylation")) + p(FPLX:PKA) regulates p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) - pmid:30985105 + pubmed:25331948 - bp(GO:"protein phosphorylation") association p(MESH:Proteins, pmod(HBP:"O-GlcNAcylation")) + p(FPLX:PKA) increases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) + + - pmid:30985105 + pubmed:25331948 - deg(a(HBP:"Dopaminergic cell groups")) positiveCorrelation path(MESH:"Parkinson Disease") + act(p(FPLX:PKA)) increases p(HGNC:CREB1, pmod(go:0006468 ! "protein phosphorylation")) - pmid:30985105 + pubmed:26631930 - deg(a(HBP:"Dopaminergic cell groups")) negativeCorrelation bp(GO:"motor behavior") + p(FPLX:PKA) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) - - - pmid:30985105 + pubmed:23001711 - complex(p(HGNC:SNCA), p(HGNC:SNCA)) association path(MESH:"Parkinson Disease") + act(p(FPLX:PKA), ma(go:0016301 ! "kinase activity")) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) - + + + pubmed:17493042 + + p(FPLX:PKA) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 214)) + - pmid:30985105 + pubmed:26692334 - complex(a(CHEBI:phospholipid), p(HGNC:SNCA)) increases bp(GO:"SNARE complex assembly") + act(p(FPLX:PKA)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 214)) - + + + pubmed:17078951 + + p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 181)) + - pmid:30985105 + pubmed:17078951 - complex(p(HGNC:SNCA), p(HGNC:VAMP2)) increases bp(GO:"SNARE complex assembly") + p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) - - - pmid:30985105 + pubmed:17078951 - p(HGNC:SNCA, frag("?_*")) increases a(HBP:"alpha-synuclein aggregates") + p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) - pmid:30985105 + pubmed:17078951 - p(HBP:"alpha-synuclein fibrils", frag("?")) increases a(HBP:"alpha-synuclein aggregates") + p(FPLX:PKA) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) - - - pmid:30985105 + pubmed:17078951 - p(HGNC:SNCA, pmod(Ph)) increases path(MESH:"Parkinson Disease") + p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) - pmid:30985105 + pubmed:17078951 - p(HGNC:SNCA, pmod(HBP:"O-GlcNAcylation")) decreases a(HBP:"alpha-synuclein aggregates") + p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 217)) - pmid:30985105 + pubmed:17078951 - p(HGNC:SNCA, pmod(HBP:"O-GlcNAcylation")) increases a(HBP:"alpha-synuclein oligomers") + p(FPLX:PKA) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 217)) - pmid:30985105 + pubmed:17078951 - p(HGNC:SNCA, pmod(HBP:"O-GlcNAcylation", Thr, 72)) decreases complex(p(HGNC:SNCA), p(HGNC:SNCA)) + p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) - pmid:30985105 + pubmed:17078951 - p(HGNC:SNCA, pmod(HBP:"O-GlcNAcylation", Thr, 72)) decreases a(HBP:"alpha-synuclein aggregates") + p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) - pmid:30985105 + pubmed:17078951 - p(HGNC:SNCA, pmod(HBP:"O-GlcNAcylation", Thr, 72)) increases a(HBP:"alpha-synuclein fibrils") + p(FPLX:PKA) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) - pmid:30985105 + pubmed:17078951 - p(HGNC:SNCA, pmod(HBP:"O-GlcNAcylation", Ser, 87)) increases a(HBP:"alpha-synuclein fibrils") + p(FPLX:PKA) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) - pmid:30985105 + pubmed:17078951 - p(HGNC:SNCA, pmod(HBP:"O-GlcNAcylation", Thr, 75)) increases a(HBP:"alpha-synuclein aggregates") + p(FPLX:PKA) negativeCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) - pmid:30985105 + pubmed:17078951 - p(HGNC:SNCA, pmod(HBP:"O-GlcNAcylation", Thr, 81)) increases a(HBP:"alpha-synuclein aggregates") + p(FPLX:PKA) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) - pmid:30985105 + pubmed:17078951 - p(HGNC:SNCA, pmod(HBP:"O-GlcNAcylation", Ser, 87), pmod(HBP:"O-GlcNAcylation", Thr, 75), pmod(HBP:"O-GlcNAcylation", Thr, 81)) causesNoChange a(HBP:"alpha-synuclein aggregates") + p(FPLX:PKA) negativeCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 212)) - pmid:30985105 + pubmed:17078951 - p(HGNC:SNCA, frag("68_77")) increases a(HBP:"alpha-synuclein aggregates") + p(FPLX:PKA) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 212)) - pmid:30985105 + pubmed:17078951 - p(HGNC:MTOR, pmod(Ph)) decreases bp(GO:autophagy) + p(FPLX:PKA) regulates act(p(HGNC:GSK3B)) - pmid:30985105 + pubmed:17078951 - act(p(MGI:Oga)) decreases bp(GO:autophagy) + p(FPLX:PKA) regulates act(p(HGNC:CDK5)) - pmid:30985105 + pubmed:26692334 - act(p(RGD:Oga)) decreases bp(GO:autophagy) + act(p(FPLX:PKA)) increases act(complex(GO:"proteasome complex")) - pmid:30985105 + pubmed:26692334 - p(RGD:Mapt, pmod(HBP:"O-GlcNAcylation")) negativeCorrelation p(RGD:Mapt, pmod(Ph)) + act(p(FPLX:PKA)) decreases a(CONSO:"Tau aggregates") - pmid:30985105 + pubmed:26692334 - p(MGI:Mapt, pmod(HBP:"O-GlcNAcylation")) negativeCorrelation p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) + act(p(FPLX:PKA)) increases bp(GO:cognition) - pmid:30985105 + pubmed:30515821 - p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) negativeCorrelation p(MGI:Mapt, pmod(HBP:"O-GlcNAcylation")) + p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 656)) decreases act(p(HGNC:DNM1L)) - pmid:28877763 + pubmed:30515821 - p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) increases act(p(MGI:Syk)) + p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 656)) decreases bp(GO:"mitochondrial fission") - pmid:28877763 + pubmed:30515821 - p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) increases a(HBP:"Tau aggregates") + p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 656)) increases path(MESH:Neuroprotection) - pmid:26458742 + pubmed:30515821 - p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) increases tloc(p(MGI:Mapt), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + complex(complex(GO:"calcineurin complex"), p(HGNC:PPP2CA)) decreases p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 656)) - pmid:26400044 + pubmed:30515821 - p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) increases complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt, pmod(HBP:hyperphosphorylation)), p(MGI:Wasf1, pmod(Ph))) + complex(complex(GO:"calcineurin complex"), p(HGNC:PPP2CA)) increases act(p(HGNC:DNM1L)) + + - pmid:25143394 + pubmed:26968346 - p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) negativeCorrelation p(MGI:Ppp1ca) + complex(GO:"calcineurin complex") increases tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) - pmid:25143394 + pubmed:26968346 - p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) negativeCorrelation p(MGI:Ppp2ca) + act(complex(GO:"calcineurin complex")) increases tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) - pmid:25143394 + pubmed:26968346 - p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) negativeCorrelation p(MGI:Ppp1cb) + act(complex(GO:"calcineurin complex")) decreases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation")) - pmid:30985105 + pubmed:30515821 - bp(GO:"glucose metabolic process") association p(MESH:Proteins, pmod(HBP:"O-GlcNAcylation")) + bp(GO:"response to oxygen-glucose deprivation") increases bp(GO:"cell death") - pmid:30985105 + pubmed:30515821 - p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) decreases p(HGNC:MAPT, pmod(Ph)) + bp(GO:"response to oxygen-glucose deprivation") increases deg(p(HGNC:SENP3)) - pmid:16630055 + pubmed:30515821 - p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) negativeCorrelation p(HGNC:MAPT, pmod(Ph)) + bp(GO:"response to oxygen-glucose deprivation") increases p(HGNC:DNM1) - pmid:30985105 + pubmed:30515821 - p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) decreases a(HBP:"Tau oligomers") + bp(GO:"response to oxygen-glucose deprivation") increases act(p(HGNC:DNM1)) - pmid:30985105 + pubmed:30515821 - p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) decreases a(HBP:"Tau oligomers") + bp(GO:"response to oxygen-glucose deprivation") increases p(HGNC:PRKN) - pmid:22833681 + pubmed:30515821 - p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) + bp(GO:"response to oxygen-glucose deprivation") increases act(p(HGNC:PRKN)) - pmid:22833681 + pubmed:30515821 - p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 205)) + bp(GO:"response to oxygen-glucose deprivation") decreases p(HGNC:PINK1) - pmid:22833681 + pubmed:30515821 - p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) + complex(p(FPLX:PKA), p(HGNC:AKAP1)) increases p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 656)) - pmid:22833681 + pubmed:30515821 - p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 356)) + complex(p(FPLX:PKA), p(HGNC:AKAP1)) regulates path(MESH:"Mitochondrial Dynamics") - pmid:22833681 + pubmed:30515821 - p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) + complex(p(FPLX:PKA), p(HGNC:AKAP1)) increases bp(GO:"dendritic cell dendrite assembly") - pmid:22833681 + pubmed:30515821 - p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) decreases a(HBP:"Tau aggregates") + complex(p(FPLX:PKA), p(HGNC:AKAP1)) decreases a(GO:synapse) - pmid:19732809 + pubmed:30515821 - p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) negativeCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + complex(p(HGNC:PPP2CA), p(HGNC:PPP2R2B)) decreases p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 656)) + + + + - pmid:30985105 + pubmed:23454242 - p(HBP:"Tau isoform F (441 aa)", pmod(HBP:"O-GlcNAcylation")) decreases a(HBP:"Tau oligomers") + p(HGNC:PPP2R2B) association a(MESH:Cytosol) - pmid:30985105 + pubmed:23454242 - p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation", Ser, 400)) association a(HBP:"Tau aggregates") + p(HGNC:PPP2R2B) increases bp(GO:cytokinesis) - pmid:30985105 + pubmed:23454242 - p(HBP:"VQIVYK motif", pmod(HBP:"O-GlcNAcylation")) decreases complex(p(HBP:"VQIVYK motif"), p(HBP:"VQIVYK motif")) + p(HGNC:PPP2R2B) association bp(GO:"cytoskeleton organization") - pmid:30985105 + pubmed:30515821 - p(HBP:"VQIVYK motif", pmod(HBP:"O-GlcNAcylation")) decreases a(HBP:"Tau fibrils") + p(HGNC:SENP3) increases deg(p(HGNC:SUMO2)) - - - pmid:26631930 + pubmed:30515821 - p(HBP:"VQIVYK motif") increases a(HBP:"Tau aggregates") + p(HGNC:SENP3) increases deg(p(HGNC:SUMO3)) - pmid:26631930 + pubmed:18675254 - p(HBP:"VQIVYK motif") increases a(HBP:"Tau aggregates") + p(HGNC:SUMO2) increases p(HGNC:APP, pmod(go:0016925 ! "protein sumoylation", Lys, 587)) - pmid:26631930 + pubmed:18675254 - p(HBP:"VQIVYK motif") increases a(HBP:"Tau fibrils") + p(HGNC:SUMO2) increases p(HGNC:APP, pmod(go:0016925 ! "protein sumoylation", Lys, 595)) - pmid:17493042 + pubmed:17346237 - p(HBP:"VQIVYK motif") partOf p(HBP:"tubulin-binding repeat 3") + p(HGNC:SUMO3) increases p(HGNC:BACE1) - pmid:17493042 + pubmed:17346237 - p(HBP:"VQIVYK motif") increases bp(GO:"neurofibrillary tangle assembly") + p(HGNC:SUMO3) increases p(HGNC:APP) - pmid:19363271 + pubmed:17346237 - p(HBP:"VQIVYK motif") association p(FPLX:HSP90) + p(HGNC:SUMO3) increases tloc(p(HGNC:APP, frag("672_711")), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:19363271 + pubmed:17346237 - p(HBP:"VQIVYK motif") isA p(HBP:"tubulin-binding repeat 4") + p(HGNC:SUMO3) increases tloc(p(HGNC:APP, frag("672_713")), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:19363271 + pubmed:12506199 - p(HBP:"VQIVYK motif") increases complex(p(FPLX:HSP90), p(HGNC:MAPT)) + p(HGNC:SUMO3) decreases a(CHEBI:amyloid-beta) + + - pmid:28002468 + pubmed:12506199 - p(HBP:"VQIVYK motif") equivalentTo p(HGNC:MAP2, frag("332_339")) + p(HGNC:SUMO3) increases p(HGNC:APP, pmod(CONSO:polysumoylation)) - pmid:11606569 + pubmed:30515821 - p(HBP:"VQIVYK motif") positiveCorrelation p(HGNC:MAPT, var("p.Lys280del")) + p(HGNC:DNM1, pmod(go:0016925 ! "protein sumoylation")) decreases bp(GO:"release of cytochrome c from mitochondria") - pmid:11606569 + pubmed:30515821 - p(HBP:"VQIVYK motif") positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) + p(HGNC:DNM1, pmod(go:0016925 ! "protein sumoylation")) decreases bp(GO:"programmed cell death") - pmid:11606569 + pubmed:30515821 - p(HBP:"VQIVYK motif") increases p(HBP:"Tau aggregates") + p(HGNC:DNM1, pmod(go:0016925 ! "protein sumoylation")) decreases tloc(p(HGNC:DNM1L), fromLoc(GO:cytosol), toLoc(GO:"mitochondrial outer membrane")) - pmid:26903089 + pubmed:30515821 - p(HBP:"VQIVYK motif") association act(p(HGNC:FKBP4)) + p(HGNC:DNM1, pmod(go:0016925 ! "protein sumoylation")) decreases bp(GO:"mitochondrial fission") - - - pmid:30985105 + pubmed:30515821 - p(HGNC:APP, pmod(HBP:"O-GlcNAcylation")) negativeCorrelation a(CHEBI:"amyloid-beta") + p(HGNC:DNM1, pmod(go:0016925 ! "protein sumoylation")) increases path(MESH:Neuroprotection) - pmid:30985105 + pubmed:30515821 - a(MESH:"1,2-dideoxy-2'-propylglucopyranoso(2,1-d)-delta 2'-thiazoline") decreases act(p(HGNC:OGA)) + p(HGNCGENEFAMILY:Caspases) increases bp(GO:"programmed cell death") - pmid:30985105 + pubmed:23516100 - a(MESH:"1,2-dideoxy-2'-propylglucopyranoso(2,1-d)-delta 2'-thiazoline") decreases a(CHEBI:"amyloid-beta") + act(p(HGNCGENEFAMILY:Caspases)) increases p(HGNC:HTT, frag("?")) - pmid:30985105 + pubmed:23516100 - a(MESH:"1,2-dideoxy-2'-propylglucopyranoso(2,1-d)-delta 2'-thiazoline") decreases path(MESH:Gliosis) + act(p(HGNCGENEFAMILY:Caspases)) increases p(HGNC:HTT, frag("?")) - pmid:30985105 + pubmed:23516100 - a(MESH:"1,2-dideoxy-2'-propylglucopyranoso(2,1-d)-delta 2'-thiazoline") increases p(MGI:Sod1, pmod(HBP:"O-GlcNAcylation")) + act(p(HGNCGENEFAMILY:Caspases)) increases p(HGNC:ATXN3, frag("?")) - pmid:30985105 + pubmed:23516100 - a(CHEBI:"prostaglandin J2") regulates path(MESH:Inflammation) + act(p(HGNCGENEFAMILY:Caspases)) increases p(HGNC:ATXN3, frag("?"), var("?")) - pmid:30985105 + pubmed:24027553 - a(CHEBI:"prostaglandin J2") increases p(HGNC:APP, frag("?")) + act(p(HGNCGENEFAMILY:Caspases)) increases deg(p(HGNC:MAPT)) - pmid:30985105 + pubmed:24027553 - a(CHEBI:"prostaglandin J2") increases p(HGNC:APP, pmod(HBP:"O-GlcNAcylation")) + act(p(HGNCGENEFAMILY:Caspases)) increases deg(p(HGNC:MAPT)) - pmid:30985105 + pubmed:24027553 - bp(GO:"vesicle transport along microtubule") association p(HGNC:HTT) + act(p(HGNCGENEFAMILY:Caspases)) increases deg(p(HGNC:MAPT)) - pmid:30985105 + pubmed:24027553 - p(HGNC:HTT, pmod(HBP:"O-GlcNAcylation")) increases a(HBP:"huntingtin aggregates") + act(p(HGNCGENEFAMILY:Caspases)) positiveCorrelation path(MESH:"Neurofibrillary Tangles") - pmid:30985105 + pubmed:24027553 - p(HGNC:HTT, pmod(HBP:"O-GlcNAcylation")) decreases deg(a(HBP:"huntingtin aggregates")) + act(p(HGNCGENEFAMILY:Caspases)) association path(MESH:"Neurofibrillary Tangles") - pmid:30985105 + pubmed:24027553 - p(HGNC:HTT, pmod(HBP:"O-GlcNAcylation")) decreases act(a(GO:autophagosome)) + act(p(HGNCGENEFAMILY:Caspases)) increases a(CONSO:"Tau aggregates") - pmid:30985105 + pubmed:24027553 - p(HGNC:HTT, pmod(HBP:"O-GlcNAcylation")) decreases bp(GO:autophagy) + act(p(HGNCGENEFAMILY:Caspases)) increases p(HGNC:MAPT, frag("?")) - pmid:30985105 + pubmed:30515821 - p(MGI:Sod1, var("?")) decreases p(MGI:Sod1, pmod(HBP:"O-GlcNAcylation")) + complex(p(HGNC:DNM1), p(HGNC:PRKN)) increases p(HGNC:DNM1, pmod(go:0016567 ! "protein ubiquitination")) - + + + pubmed:30515821 + + complex(p(HGNC:DNM1), p(HGNC:PRKN)) decreases act(p(HGNC:DNM1)) + - pmid:28877763 + pubmed:30515821 - p(HGNC:MAPT, pmod(HBP:misfolded)) positiveCorrelation act(p(HGNC:SYK)) + path(OMIT:0016183) increases p(HGNC:DNM1) - pmid:29311797 + pubmed:30515821 - p(HGNC:MAPT, pmod(HBP:misfolded)) increases bp(GO:"cell death in response to oxidative stress") + path(OMIT:0016183) increases act(p(HGNC:DNM1)) - pmid:16566606 + pubmed:30515821 - p(HGNC:MAPT, pmod(HBP:misfolded)) association p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) + path(OMIT:0016183) increases p(HGNC:PRKN) - pmid:16566606 + pubmed:30515821 - p(HGNC:MAPT, pmod(HBP:misfolded)) association p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) + path(OMIT:0016183) increases act(p(HGNC:PRKN)) - pmid:16566606 + pubmed:30515821 - p(HGNC:MAPT, pmod(HBP:misfolded)) association p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) + composite(p(HGNC:DNM1), p(HGNC:PRKN)) regulates path(MESH:"Mitochondrial Dynamics") - pmid:16566606 + pubmed:30515821 - p(HGNC:MAPT, pmod(HBP:misfolded)) association p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) + composite(p(HGNC:DNM1), p(HGNC:PRKN)) increases act(p(HGNC:PRKN)) - + + + pubmed:30515821 + + p(HGNC:DNM1, pmod(go:0017014 ! "protein nitrosylation", Cys, 644)) increases act(p(HGNC:DNM1), ma(GO:"GTPase activity")) + - pmid:25374103 + pubmed:30515821 - composite(p(HGNC:MAPT), p(HGNC:MARK2)) positiveCorrelation bp(GO:"anterograde axonal transport") + p(HGNC:DNM1, pmod(go:0017014 ! "protein nitrosylation", Cys, 644)) decreases a(MESH:"Dendritic Spines") - pmid:25374103 + pubmed:30515821 - p(MGI:Stub1) decreases act(p(MGI:Casp3)) + p(HGNC:DNM1, pmod(go:0017014 ! "protein nitrosylation", Cys, 644)) decreases path(MESH:"Wounds and Injuries") - pmid:25374103 + pubmed:30515821 - p(MGI:Stub1) decreases p(HBP:"Tau C3") + p(HGNC:DNM1, pmod(go:0017014 ! "protein nitrosylation", Cys, 644)) negativeCorrelation path(MESH:"Mitochondrial Dynamics") - pmid:29311797 + pubmed:30515821 - p(MGI:Stub1) increases deg(p(MGI:Mapt, pmod(Ph))) + p(HGNC:DNM1, pmod(go:0017014 ! "protein nitrosylation", Cys, 644)) increases path(DOID:"Huntington's disease") - pmid:29311797 + pubmed:30515821 - p(MGI:Stub1) increases deg(p(MGI:Mapt, pmod(HBP:misfolded))) + p(NCBIGENE:15194, var("?")) increases a(CHEBI:"nitric oxide") + + - pmid:25374103 + pubmed:30515821 - composite(p(HBP:"Tau C3"), p(HGNC:STUB1)) decreases p(HBP:"Tau C3") + p(NCBIGENE:74006, pmod(go:0017014 ! "protein nitrosylation", Cys, 644)) decreases a(MESH:"Dendritic Spines") - - - pmid:25374103 + pubmed:30515821 - composite(p(HBP:"Tau C3"), p(HGNC:STUB1)) increases complex(p(HBP:"Tau C3"), p(HGNC:STUB1)) + p(NCBIGENE:74006, pmod(go:0017014 ! "protein nitrosylation", Cys, 644)) decreases path(MESH:"Wounds and Injuries") + + + + - pmid:25374103 + pubmed:30515821 - composite(p(HBP:"Tau C3"), p(HGNC:STUB1)) increases complex(p(HBP:"Tau C3"), p(HGNC:STUB1)) + p(HGNC:DNM1, var("p.Cys644Ala")) decreases p(HGNC:DNM1, pmod(go:0017014 ! "protein nitrosylation", Cys, 644)) - pmid:25374103 + pubmed:30515821 - composite(p(HBP:"Tau C3"), p(HGNC:STUB1)) causesNoChange a(MESH:"HSP70 Heat-Shock Proteins") + path(OMIT:0010462) positiveCorrelation p(HGNC:DNM1) - pmid:25374103 + pubmed:30515821 - composite(p(HBP:"Tau C3"), p(HGNC:STUB1)) decreases p(HGNC:CASP3, frag("?")) + bp(GO:"synaptic vesicle cycle") positiveCorrelation p(HGNC:DNM1) - pmid:25374103 + pubmed:30515821 - composite(p(HBP:"Tau C3"), p(HGNC:STUB1)) increases bp(GO:"mitochondrion transport along microtubule") + bp(GO:"negative regulation of mitophagy") negativeCorrelation path(MESH:"Mitochondrial Dynamics") - pmid:25374103 + pubmed:30515821 - composite(p(HBP:"Tau C3"), p(HGNC:STUB1)) increases bp(GO:"mitochondrion transport along microtubule") + bp(GO:"negative regulation of mitophagy") increases path(OMIT:0002643) - - - + + + pubmed:30515821 + + composite(p(HGNC:DNM1), p(HGNC:SQSTM1)) decreases a(OMIT:0012627) + - pmid:25374103 + pubmed:30515821 - composite(p(HBP:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) decreases p(HBP:"Tau isoform F (441 aa)") + composite(a(CHEBI:amyloid-beta), p(HGNC:DNM1)) increases bp(GO:"mitochondrial fission") - - - pmid:25374103 + pubmed:30515821 - composite(p(HBP:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) decreases p(HGNC:CASP3, frag("?")) + composite(a(CHEBI:amyloid-beta), p(HGNC:DNM1)) negativeCorrelation path(MESH:"Mitochondrial Dynamics") - pmid:25374103 + pubmed:30515821 - composite(p(HBP:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) increases complex(p(HBP:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) + composite(a(CHEBI:amyloid-beta), p(HGNC:DNM1)) increases deg(a(GO:synapse)) - pmid:25374103 + pubmed:30515821 - composite(p(HBP:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) decreases p(HBP:"Tau C3") + composite(a(CHEBI:amyloid-beta), p(HGNC:DNM1)) negativeCorrelation bp(GO:"axonal transport") - pmid:25374103 + pubmed:30515821 - composite(p(HBP:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) increases bp(GO:"mitochondrion transport along microtubule") + composite(a(CHEBI:amyloid-beta), p(HGNC:DNM1)) increases path(DOID:"Alzheimer's disease") - pmid:25374103 + pubmed:30515821 - composite(p(HBP:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) increases bp(GO:"mitochondrion transport along microtubule") + composite(a(CHEBI:amyloid-beta), p(HGNC:DNM1)) decreases p(HGNC:DNM1) - - - pmid:25374103 + pubmed:30515821 - composite(p(HBP:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) decreases p(HBP:"4R tau", var("p.Lys280del")) + composite(a(CHEBI:amyloid-beta), p(HGNC:DNM1)) decreases p(HGNC:FIS1) - pmid:25374103 + pubmed:30515821 - composite(p(HBP:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) decreases p(HBP:"4R tau", var("p.Lys280del")) + composite(a(CHEBI:amyloid-beta), p(HGNC:DNM1)) increases p(HGNC:MFN1) - - - pmid:25374103 + pubmed:30515821 - composite(p(HBP:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) negativeCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262)) + composite(a(CHEBI:amyloid-beta), p(HGNC:DNM1)) increases p(HGNC:MFN2) - pmid:25374103 + pubmed:30515821 - composite(p(HBP:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) causesNoChange a(MESH:"HSP70 Heat-Shock Proteins") + composite(a(CHEBI:amyloid-beta), p(HGNC:DNM1)) increases p(HGNC:OPA1) - pmid:25374103 + pubmed:30515821 - composite(p(HBP:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) increases bp(GO:"mitochondrion transport along microtubule") + composite(a(CHEBI:amyloid-beta), p(HGNC:DNM1)) increases p(HGNC:NRF1) - pmid:25374103 + pubmed:30515821 - composite(p(HBP:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) increases bp(GO:"mitochondrion transport along microtubule") + composite(a(CHEBI:amyloid-beta), p(HGNC:DNM1)) increases p(HGNC:NFE2L2) - + + + pubmed:30515821 + + composite(a(CHEBI:amyloid-beta), p(HGNC:DNM1)) increases p(HGNC:PPARGC1A) + - pmid:25374103 + pubmed:30515821 - composite(p(FPLX:HSP90), p(HGNC:STUB1)) increases complex(p(FPLX:HSP90), p(HGNC:STUB1)) + composite(a(CHEBI:amyloid-beta), p(HGNC:DNM1)) increases p(HGNC:TFAM) - - - + + + pubmed:30515821 + + composite(a(CHEBI:amyloid-beta), p(HGNC:DNM1)) increases g(HGNC:SYP) + - + + + pubmed:30515821 + + composite(a(CHEBI:amyloid-beta), p(HGNC:DNM1)) increases g(HGNC:DLG4) + - pmid:25374103 + pubmed:30515821 - composite(a(MESH:"HSP70 Heat-Shock Proteins"), p(HGNC:STUB1)) increases complex(a(MESH:"HSP70 Heat-Shock Proteins"), p(HGNC:STUB1)) + composite(p(HGNC:DNM1), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) increases bp(GO:"mitochondrial fission") - + + + pubmed:30515821 + + composite(p(HGNC:DNM1), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) negativeCorrelation path(MESH:"Mitochondrial Dynamics") + - pmid:25374103 + pubmed:30515821 - complex(a(MESH:"HSP70 Heat-Shock Proteins"), p(HGNC:STUB1)) increases complex(a(MESH:"HSP70 Heat-Shock Proteins"), p(HGNC:STUB1), p(MESH:Proteins, pmod(HBP:misfolded))) + composite(p(HGNC:DNM1), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) increases deg(a(GO:synapse)) - - - + + + pubmed:30515821 + + composite(p(HGNC:DNM1), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) negativeCorrelation bp(GO:"axonal transport") + - + + + pubmed:30515821 + + composite(p(HGNC:DNM1), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) increases path(DOID:"Alzheimer's disease") + - pmid:25374103 + pubmed:30515821 - composite(p(HBP:"4R tau"), p(HGNC:STUB1)) increases a(MESH:"HSP70 Heat-Shock Proteins") + composite(p(HGNC:DNM1), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) decreases p(HGNC:DNM1) - pmid:25374103 + pubmed:30515821 - p(PFAM:"CHIP_TPR_N") increases complex(a(MESH:"HSP70 Heat-Shock Proteins"), p(FPLX:HSP90), p(HGNC:STUB1)) + composite(p(HGNC:DNM1), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) decreases p(HGNC:FIS1) - + + + pubmed:30515821 + + composite(p(HGNC:DNM1), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) increases p(HGNC:MFN1) + - + + + pubmed:30515821 + + composite(p(HGNC:DNM1), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) increases p(HGNC:MFN2) + - + + + pubmed:30515821 + + composite(p(HGNC:DNM1), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) increases p(HGNC:OPA1) + - + + + pubmed:30515821 + + composite(p(HGNC:DNM1), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) increases p(HGNC:NRF1) + - pmid:25374103 + pubmed:30515821 - complex(p(HGNC:STUB1), p(INTERPRO:"U box domain")) increases p(HBP:"Tau isoform F (441 aa)") + composite(p(HGNC:DNM1), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) increases p(HGNC:NFE2L2) - pmid:25374103 + pubmed:30515821 - complex(p(HGNC:STUB1), p(INTERPRO:"U box domain")) increases p(HBP:"4R tau", var("p.Lys280del")) + composite(p(HGNC:DNM1), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) increases p(HGNC:PPARGC1A) - + + + pubmed:30515821 + + composite(p(HGNC:DNM1), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) increases p(HGNC:TFAM) + - pmid:28877763 + pubmed:30515821 - act(p(MGI:Syk)) positiveCorrelation bp(GO:"microglial cell activation") + composite(p(HGNC:DNM1), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) increases g(HGNC:SYP) - - - pmid:28877763 + pubmed:30515821 - act(p(MGI:Syk)) positiveCorrelation a(HBP:"amyloid-beta aggregates") + composite(p(HGNC:DNM1), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) increases g(HGNC:DLG4) - pmid:28877763 + pubmed:30515821 - act(p(MGI:Syk)) positiveCorrelation a(MESH:Neurites) + bp(GO:"immunological synapse formation") positiveCorrelation p(HGNC:DNM1) - + + + pubmed:30515821 + + bp(GO:"immunological synapse formation") negativeCorrelation path(MESH:"Cell Aggregation") + - pmid:28877763 + pubmed:30515821 - p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Tyr, 18)) + path(MESH:"Cell Aggregation") negativeCorrelation bp(GO:"immunological synapse formation") - pmid:25331948 + pubmed:30515821 - p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Tyr, 18)) + path(MESH:"Cell Aggregation") increases path(HP:"Abnormality of forebrain morphology") - pmid:28877763 + pubmed:30515821 - p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 396)) + p(HGNC:NRF1) increases a(MESH:Mitochondria) + + - pmid:25331948 + pubmed:30515821 - p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 396)) + p(HGNC:PPARGC1A) increases a(MESH:Mitochondria) - pmid:28877763 + pubmed:27299292 - p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 404)) + p(HGNC:PPARGC1A) increases a(MESH:Mitochondria) - pmid:25331948 + pubmed:21718217 - p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 404)) + p(HGNC:PPARGC1A) association bp(MESH:"Energy Metabolism") - pmid:28877763 + pubmed:20556492 - p(MGI:Syk) positiveCorrelation p(MGI:Mapt) + p(HGNC:PPARGC1A) regulates bp(MESH:"Energy Metabolism") - pmid:25331948 + pubmed:21718217 - p(MGI:Syk) increases a(CHEBI:"amyloid-beta") + p(HGNC:PPARGC1A) association path(MESH:"Insulin Resistance") - pmid:25331948 + pubmed:21718217 - p(MGI:Syk) decreases deg(a(CHEBI:"amyloid-beta")) + p(HGNC:PPARGC1A) increases bp(GO:"fat cell differentiation") - pmid:25331948 + pubmed:20556492 - p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 202)) + p(HGNC:PPARGC1A) regulates bp(MESH:"Mitochondrial Dynamics") - pmid:28877763 + pubmed:20556492 - p(MGI:Syk, pmod(Ph)) positiveCorrelation bp(GO:"microglial cell activation") + p(HGNC:PPARGC1A) regulates bp(GO:"mitochondrion organization") - pmid:28877763 + pubmed:20556492 - p(MGI:Syk, pmod(Ph)) positiveCorrelation a(HBP:"amyloid-beta aggregates") + p(HGNC:PPARGC1A) regulates bp(GO:"cellular respiration") - pmid:28877763 + pubmed:20556492 - p(MGI:Syk, pmod(Ph)) partOf a(HBP:"dystrophic neurite") + p(HGNC:PPARGC1A) increases a(CHEBI:"reactive oxygen species") - pmid:28877763 + pubmed:20556492 - p(MGI:Syk, pmod(Ph)) increases act(p(MGI:Syk)) + p(HGNC:PPARGC1A) regulates bp(GO:detoxification) - pmid:28877763 + pubmed:20556492 - p(MGI:Mapt, var("p.Pro301Ser")) increases p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) + p(HGNC:PPARGC1A) regulates bp(MESH:Thermogenesis) + + - pmid:28877763 + pubmed:26968346 - p(MGI:Mapt, var("p.Pro301Ser")) increases p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) + p(HGNC:PPARGC1A) positiveCorrelation bp(GO:"nervous system process") - pmid:28877763 + pubmed:26968346 - p(MGI:Mapt, var("p.Pro301Ser")) increases a(HBP:"Tau aggregates") + p(HGNC:PPARGC1A) increases p(HGNC:TFEB) - pmid:28877763 + pubmed:27299292 - p(MGI:Syk, pmod(Ph, Tyr, 525)) association a(HBP:"Tau aggregates") + p(HGNC:PPARGC1A) regulates p(HGNC:TFEB) - pmid:28877763 + pubmed:27299292 - p(MGI:Syk, pmod(Ph, Tyr, 526)) association a(HBP:"Tau aggregates") + act(p(HGNC:PPARGC1A)) regulates act(p(HGNC:TFEB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) - pmid:28877763 + pubmed:27299292 - p(HGNC:SYK, pmod(Ph)) association a(HBP:"Tau aggregates") + p(HGNC:PPARGC1A) increases act(p(HGNC:TFEB)) + + - pmid:28877763 + pubmed:27299292 - p(HGNC:SYK, pmod(Ph)) positiveCorrelation a(HBP:"Tau aggregates") + p(HGNC:PPARGC1A) association bp(GO:"insulin receptor signaling pathway") - pmid:28877763 + pubmed:27299292 - p(HGNC:SYK, pmod(Ph)) association p(MGI:Mapt, pmod(Ph, Ser, 202)) + p(HGNC:PPARGC1A) association p(MESH:"AMP-Activated Protein Kinases") - pmid:28877763 + pubmed:27299292 - p(HGNC:SYK, pmod(Ph)) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 18)) + p(HGNC:PPARGC1A) association complex(MESH:"Mechanistic Target of Rapamycin Complex 1") - pmid:28877763 + pubmed:27299292 - p(HGNC:SYK, pmod(Ph)) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Tyr, 18)) + p(HGNC:PPARGC1A) association complex(MESH:"Mechanistic Target of Rapamycin Complex 2") - pmid:28877763 + pubmed:27299292 - p(HGNC:SYK, pmod(Ph)) positiveCorrelation path(MESH:"Plaque, Amyloid") + p(HGNC:PPARGC1A) regulates r(HGNC:TFEB) - pmid:28420982 + pubmed:27299292 - a(HBP:"granular tau oligomers") increases a(HBP:"Tau fibrils") + p(HGNC:PPARGC1A) increases r(HGNC:TFEB) - pmid:28420982 + pubmed:27299292 - bp(GO:"mitochondrion organization") decreases bp(HP:Neurodegeneration) + p(HGNC:PPARGC1A) increases r(HGNC:TFEB) - - - pmid:28420982 + pubmed:27299292 - a(MESH:Exosomes) association sec(p(HGNC:MAPT)) + act(p(HGNC:PPARGC1A), ma(GO:"core promoter binding")) increases complex(p(HGNC:PPARGC1A), r(HGNC:TFEB)) + + - pmid:29238289 + pubmed:27299292 - act(a(MESH:Exosomes)) association p(HGNC:MAPT) + act(p(HGNC:PPARGC1A)) increases complex(p(HGNC:PPARGC1A), p(HGNC:RXRA), r(HGNC:TFEB)) - pmid:28420982 + pubmed:30515821 - a(MESH:Exosomes) association path(MESH:"Plaque, Amyloid") + p(HGNC:TFAM) increases a(MESH:Mitochondria) - pmid:28420982 + pubmed:29238289 - a(MESH:Exosomes) association p(HGNC:MAPT, pmod(Ph, Thr, 181)) + a(MESH:"Transport Vesicles") association tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:28420982 + pubmed:30515821 - a(GO:microvesicle) association sec(p(HGNC:MAPT)) + complex(p(HGNC:DNM1), p(HGNC:LRRK2, var("p.Gly2019Ser"))) increases p(HGNC:DNM1, pmod(go:0006468 ! "protein phosphorylation", Thr, 595)) - pmid:28420982 + pubmed:30515821 - a(GO:microvesicle) regulates sec(p(HGNC:MAPT)) + complex(p(HGNC:DNM1), p(HGNC:LRRK2, var("p.Gly2019Ser"))) increases p(HGNC:DNM1, pmod(go:0006468 ! "protein phosphorylation", Ser, 616)) - - - - - pmid:28420982 + pubmed:30515821 - complex(a(GO:vesicle), a(MESH:"Cell Membrane")) increases sec(p(HGNC:MAPT)) + p(HGNC:DNM1, pmod(go:0006468 ! "protein phosphorylation", Thr, 595)) increases act(p(HGNC:DNM1)) - + + + pubmed:30515821 + + p(HGNC:DNM1, pmod(go:0006468 ! "protein phosphorylation", Ser, 616)) increases act(p(HGNC:DNM1)) + - pmid:28420982 + pubmed:30515821 - complex(p(HGNC:CHRM1), p(HGNC:MAPT)) increases path(MESH:Tauopathies) + act(a(NCIT:C12616)) increases p(HGNC:LRRK2) - + + + pubmed:30515821 + + p(HGNC:LRRK2, var("p.Glu192Lys")) causesNoChange act(p(HGNC:LRRK2), ma(GO:"kinase activity")) + - pmid:28420982 + pubmed:30515821 - complex(p(HGNC:CHRM3), p(HGNC:MAPT)) increases path(MESH:Tauopathies) + p(HGNC:LRRK2, var("p.Glu192Lys")) causesNoChange act(p(HGNC:DNM1)) - - - pmid:28420982 + pubmed:30515821 - complex(a(HBP:"Tau aggregates"), a(MESH:"Heparan Sulfate Proteoglycans")) increases tloc(a(HBP:"Tau aggregates"), fromLoc(GO:"extracellular space"), toLoc(GO:"intracellular part")) + p(HGNC:LRRK2, var("p.Glu192Lys")) association p(HGNC:LRRK2, pmod(go:0006468 ! "protein phosphorylation", Ser, 935)) - pmid:28420982 + pubmed:30515821 - complex(a(HBP:"Tau aggregates"), a(MESH:"Heparan Sulfate Proteoglycans")) increases a(HBP:"Tau aggregates") + p(HGNC:LRRK2, var("p.Glu192Lys")) increases a(CHEBI:N-methyl-4-phenylpyridinium) - - - pmid:28420982 + pubmed:30515821 - complex(a(HBP:"Tau aggregates"), a(MESH:"Heparan Sulfate Proteoglycans")) increases complex(a(GO:"cell surface"), a(HBP:"Tau aggregates")) + p(HGNC:LRRK2, var("p.Glu192Lys")) decreases complex(p(HGNC:DNM1), p(HGNC:LRRK2)) - pmid:28420982 + pubmed:30515821 - complex(a(HBP:"Tau aggregates"), a(MESH:"Heparan Sulfate Proteoglycans")) increases bp(GO:macropinocytosis) + p(HGNC:LRRK2, var("p.Glu192Lys")) decreases bp(GO:"mitochondrial fission") - pmid:28420982 + pubmed:30515821 - a(MESH:"Heparan Sulfate Proteoglycans") association bp(GO:"neurofibrillary tangle assembly") + p(HGNC:LRRK2, pmod(go:0006468 ! "protein phosphorylation", Ser, 935)) association p(HGNC:LRRK2, var("p.Glu192Lys")) - pmid:28420982 + pubmed:30515821 - a(MESH:"Heparan Sulfate Proteoglycans") association a(HBP:"dense core plaques") + a(CHEBI:N-methyl-4-phenylpyridinium) association a(MESH:Mitochondria) + + - pmid:28420982 + pubmed:19293145 - a(MESH:"Heparan Sulfate Proteoglycans") association path(MESH:"Cerebral Amyloid Angiopathy, Familial") + act(a(CHEBI:N-methyl-4-phenylpyridinium)) increases path(CONSO:neurotoxicity) - pmid:28420982 + pubmed:26968346 - a(MESH:"Heparan Sulfate Proteoglycans") increases a(HBP:"Tau fibrils") + a(CHEBI:N-methyl-4-phenylpyridinium) increases bp(GO:"cell death") - pmid:28420982 + pubmed:30515821 - a(MESH:"Heparan Sulfate Proteoglycans") increases a(HBP:"amyloid-beta fibrils") + p(HGNC:PINK1) decreases bp(GO:"mitochondrial fission") - pmid:28420982 + pubmed:30515821 - a(MESH:"Heparan Sulfate Proteoglycans") increases complex(a(GO:"cell surface"), a(HBP:"Tau aggregates")) + p(HGNC:PINK1) decreases bp(GO:"mitochondrial fission") - pmid:28420982 + pubmed:30515821 - a(MESH:"Heparan Sulfate Proteoglycans") increases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular space"), toLoc(GO:"intracellular part")) + p(HGNC:PINK1) positiveCorrelation path(MESH:"Mitochondrial Dynamics") - pmid:28420982 + pubmed:30515821 - a(HBP:"dense core plaques") association a(MESH:"Heparan Sulfate Proteoglycans") + p(HGNC:PINK1) decreases bp(GO:"neuron death") - + + + pubmed:30515821 + + p(HGNC:PINK1) increases a(CHEBI:ATP) + - pmid:28420982 + pubmed:30515821 - a(HBP:"Tau annular protofibrils") association path(MESH:Tauopathies) + p(HGNC:PINK1) positiveCorrelation bp(OMIT:0025241) @@ -144330,1390 +146113,1351 @@

Statements

- pmid:28420982 + pubmed:30515821 - complex(p(HGNC:DNM1L), p(HGNC:MAPT)) increases bp(HP:Neurodegeneration) + p(HGNC:PINK1) decreases tloc(p(HGNC:DNM1L), fromLoc(GO:cytosol), toLoc(GO:"mitochondrial outer membrane")) - pmid:28420982 + pubmed:30515821 - p(HGNC:MAPT, frag("1_421")) decreases bp(GO:"mitochondrion organization") + p(HGNC:PINK1) decreases path(DOID:ischemia) - pmid:26631930 + pubmed:30688256 - p(HGNC:MAPT, frag("1_421")) increases a(HBP:"Tau aggregates") + p(HGNC:PINK1) decreases path(HBP:"mitochondrial dysfunction") - pmid:26631930 + pubmed:30688256 - p(HGNC:MAPT, frag("1_421")) increases a(GO:"neurofibrillary tangle") + p(HGNC:PINK1) decreases bp(GO:"apoptotic process") - pmid:28420982 + pubmed:30688256 - p(HGNC:MAPT, frag("421_?")) decreases bp(GO:"mitochondrion organization") + p(HGNC:PINK1) decreases bp(GO:"apoptotic process") - - - - - pmid:28420982 + pubmed:30688256 - complex(p(HGNC:APAF1), p(HGNC:CYCS)) increases act(p(HGNC:CASP9)) + p(HGNC:PINK1) increases act(p(HGNC:PRKN)) - pmid:23702978 + pubmed:30688256 - complex(p(HGNC:APAF1), p(HGNC:CYCS)) increases bp(GO:"apoptosome assembly") + p(HGNC:PINK1, loc(GO:"mitochondrial outer membrane")) increases act(p(HGNC:PRKN)) - pmid:29311797 + pubmed:21722302 - path(MESH:"Chronic Traumatic Encephalopathy") isA path(MESH:Tauopathies) + p(HGNC:PINK1) increases p(HGNC:PRKN) - pmid:29276758 + pubmed:30688256 - path(MESH:"Chronic Traumatic Encephalopathy") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 280)) + p(HGNC:PINK1) association path(MESH:"Neurodegenerative Diseases") - pmid:29311797 + pubmed:30688256 - p(HGNC:HSP90AA1) association bp(GO:growth) + p(HGNC:PINK1) association path(MESH:"Parkinson Disease") - pmid:29311797 + pubmed:30688256 - p(HGNC:HSP90AA1) association bp(GO:"regulation of cell cycle") + p(HGNC:PINK1, loc(GO:"mitochondrial inner membrane")) increases deg(p(HGNC:PINK1)) + + - pmid:29311797 + pubmed:30688256 - p(HGNC:HSP90AA1) association bp(MESH:Cytoprotection) + p(HGNC:PINK1) increases act(a(MESH:Mitochondria)) - pmid:29311797 + pubmed:30688256 - p(HGNC:HSP90AA1) association path(MESH:"Neoplasm Metastasis") + p(HGNC:PINK1) decreases path(MESH:"Oxidative Stress") - pmid:29311797 + pubmed:30688256 - bp(GO:growth) association p(HGNC:HSP90AA1) + p(HGNC:PINK1) increases bp(GO:mitophagy) - pmid:29311797 + pubmed:30027901 - bp(GO:"regulation of cell cycle") association p(HGNC:HSP90AA1) + p(HGNC:PINK1) decreases bp(GO:mitophagy) - pmid:29311797 + pubmed:26968346 - bp(MESH:Cytoprotection) association p(HGNC:HSP90AA1) + p(HGNC:PINK1) association bp(GO:mitophagy) - pmid:29311797 + pubmed:30027901 - path(MESH:"Neoplasm Metastasis") association p(HGNC:HSP90AA1) + p(HGNC:PINK1) decreases bp(GO:"mitochondrial fragmentation involved in apoptotic process") - pmid:29311797 + pubmed:21722302 - bp(GO:"embryo development") association p(HGNC:HSP90AB1) + p(HGNC:PINK1) decreases bp(MESH:"Oxidative Stress") - pmid:29311797 + pubmed:21722302 - bp(GO:"cell maturation") association p(HGNC:HSP90AB1) + p(HGNC:PINK1) decreases path(CONSO:"mitochondrial dysfunction") - pmid:29311797 + pubmed:21722302 - bp(GO:"adaptation of signaling pathway") association p(HGNC:HSP90AB1) + p(HGNC:PINK1) decreases bp(MESH:Apoptosis) + + - pmid:29311797 + pubmed:21722302 - p(HGNC:PPID) isA a(MESH:Immunophilins) + p(HGNC:PINK1) regulates bp(MESH:"Protein Stability") - pmid:29311797 + pubmed:26968346 - p(HGNC:PPID) decreases a(HBP:"Tau fibrils") + p(HGNC:PINK1) increases tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) - pmid:29311797 + pubmed:26968346 - p(HGNC:PPID) decreases a(HBP:"Tau aggregates") + p(HGNC:PINK1) increases act(p(HGNC:TFEB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) - pmid:29311797 + pubmed:27299292 - p(HGNC:PPID) increases bp(GO:memory) + p(HGNC:PINK1) association composite(p(HGNC:MITF), p(HGNC:TFE3), p(HGNC:TFEB)) + + - pmid:29311797 + pubmed:30515821 - p(HGNC:PPID) decreases bp(GO:"neuron apoptotic process") + composite(a(CHEBI:"nitric oxide"), a(CHEBI:N-methyl-4-phenylpyridinium)) increases p(HGNC:DNM1) - pmid:29311797 + pubmed:30515821 - p(HGNC:FKBPL) isA a(MESH:Immunophilins) + composite(a(CHEBI:"nitric oxide"), a(CHEBI:N-methyl-4-phenylpyridinium)) increases p(HGNC:PRKN, pmod(go:0017014 ! "protein nitrosylation")) - - - - - - - - - - - - - - - - - - - - - - - - - - - - - pmid:29311797 + pubmed:30515821 - complex(p(FPLX:HSP90), p(HGNC:AIP)) regulates bp(GO:"glucocorticoid receptor signaling pathway") + p(HGNC:PRKN, pmod(go:0017014 ! "protein nitrosylation")) decreases deg(p(HGNC:DNM1)) - - - - - pmid:29311797 + pubmed:30515821 - complex(p(HGNC:FKBP4), p(HGNC:MAPT)) increases a(HBP:"Tau aggregates") + bp(OMIT:0025241) positiveCorrelation p(HGNC:PINK1) - pmid:29311797 + pubmed:30515821 - bp(GO:"glucocorticoid receptor signaling pathway") association a(HBP:"Tau aggregates") + bp(OMIT:0025241) negativeCorrelation p(HGNC:PINK1, var("p.Try437?")) - pmid:29311797 + pubmed:30515821 - p(HGNC:TOMM34) decreases path(MESH:Tauopathies) + bp(OMIT:0025241) negativeCorrelation p(HGNC:PINK1, var("p.Lys219Met")) - - - - - pmid:29311797 + pubmed:30515821 - complex(p(FPLX:HSP90), p(HGNC:CDC37)) increases p(HGNC:GSK3B) + p(HGNC:PINK1, var("p.Try437?")) negativeCorrelation path(MESH:"Mitochondrial Dynamics") - pmid:29311797 + pubmed:30515821 - complex(p(FPLX:HSP90), p(HGNC:CDC37)) increases p(HGNC:MAPK13) + p(HGNC:PINK1, var("p.Try437?")) increases bp(GO:"neuron death") - pmid:21367866 + pubmed:30515821 - complex(p(FPLX:HSP90), p(HGNC:CDC37)) positiveCorrelation act(p(HGNC:AKT1), ma(kin)) + p(HGNC:PINK1, var("p.Try437?")) decreases a(CHEBI:ATP) - pmid:29311797 + pubmed:30515821 - act(p(HGNC:MAPK13), ma(kin)) increases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:PINK1, var("p.Try437?")) negativeCorrelation bp(OMIT:0025241) - pmid:11943212 + pubmed:30515821 - p(HGNC:MAPK13) increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) + p(HGNC:PINK1, var("p.Lys219Met")) negativeCorrelation path(MESH:"Mitochondrial Dynamics") - pmid:11943212 + pubmed:30515821 - p(HGNC:MAPK13) increases p(HGNC:MAPT, pmod(Ph, Thr, 396)) + p(HGNC:PINK1, var("p.Lys219Met")) increases bp(GO:"neuron death") - pmid:11943212 + pubmed:30515821 - p(HGNC:MAPK13) increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + p(HGNC:PINK1, var("p.Lys219Met")) decreases a(CHEBI:ATP) - pmid:11943212 + pubmed:30515821 - p(HGNC:MAPK13) increases p(HGNC:MAPT, pmod(Ph, Ser, 422)) + p(HGNC:PINK1, var("p.Lys219Met")) negativeCorrelation bp(OMIT:0025241) - pmid:29311797 + pubmed:27190210 - p(MGI:Ahsa1) increases a(HBP:"Tau oligomers") + path(DOID:ischemia) association bp(GO:"synaptic transmission, cholinergic") - pmid:29311797 + pubmed:21861815 - p(MGI:Ahsa1) increases bp(GO:"neuron apoptotic process") + path(DOID:ischemia) increases path(DOID:"Alzheimer's disease") - - - - - pmid:29311797 + pubmed:30515821 - p(HGNC:S100A1) increases p(HGNC:MAPT) + complex(p(HGNC:DNM1L), p(HGNC:HTT, pmod(CONSO:"CAG repeats"))) negativeCorrelation path(MESH:"Mitochondrial Dynamics") - pmid:29311797 + pubmed:30515821 - p(HGNC:S100A1) increases p(HGNC:MAPT, pmod(Ph)) + complex(p(HGNC:DNM1L), p(HGNC:HTT, pmod(CONSO:"CAG repeats"))) negativeCorrelation bp(GO:"axonal transport") - - - pmid:29311797 + pubmed:30515821 - complex(p(FPLX:HSP90), p(HGNC:FNIP1)) decreases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) + complex(p(HGNC:DNM1L), p(HGNC:HTT, pmod(CONSO:"CAG repeats"))) increases path(DOID:"Huntington's disease") - - - - - - - - - pmid:29311797 + pubmed:30515821 - complex(p(FPLX:HSP90), p(HGNC:FNIP1), p(HGNC:FNIP2)) increases p(HGNC:FLCN) + complex(p(HGNC:DNM1L), p(HGNC:HTT, pmod(CONSO:"CAG repeats"))) increases act(p(HGNC:DNM1L)) - - - - - pmid:29311797 + pubmed:30515821 - p(FPLX:HSP90, pmod(Ph)) decreases act(p(FPLX:HSP90)) + complex(p(HGNC:DNM1L), p(HGNC:HTT, pmod(CONSO:"CAG repeats"))) increases act(p(HGNC:DNM1L), ma(GO:"GTPase activity")) - pmid:29311797 + pubmed:30515821 - p(FPLX:HSP90, pmod(Ac)) decreases complex(a(CHEBI:ATP), p(FPLX:HSP90)) + complex(p(HGNC:DNM1L), p(HGNC:HTT, pmod(CONSO:"CAG repeats"))) increases bp(GO:"mitochondrial fission") - pmid:29311797 + pubmed:30515821 - p(FPLX:HSP90, pmod(NO)) decreases act(p(FPLX:HSP90)) + complex(p(HGNC:DNM1L), p(HGNC:HTT, pmod(CONSO:"CAG repeats"))) increases bp(GO:"neuron death") - - - pmid:29311797 - - p(FPLX:HSP90, pmod(Ub)) decreases act(p(FPLX:HSP90)) - + - pmid:29311797 + pubmed:30515821 - p(FPLX:HSP90, pmod(GO:"protein oxidation")) decreases act(p(FPLX:HSP90)) + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases a(CHEBI:"nitric oxide") - pmid:29311797 + pubmed:30515821 - a(HBP:EC102) increases deg(p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases bp(GO:"mitochondrial fission") - pmid:29311797 + pubmed:30515821 - a(PUBCHEM:14719853) decreases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases path(MESH:"Wounds and Injuries") - pmid:29311797 + pubmed:30362565 - a(PUBCHEM:14719853) decreases p(MGI:Mapt) + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases a(CONSO:"huntingtin aggregates") - pmid:29311797 + pubmed:30027901 - a(CHEBI:"withaferin A") decreases act(p(FPLX:HSP90)) + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases a(CONSO:"huntingtin aggregates") + + - pmid:29311797 + pubmed:30027901 - a(CHEBI:"withaferin A") decreases act(p(HGNC:CDC37)) + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases a(CONSO:"huntingtin aggregates") - pmid:29311797 + pubmed:30027901 - a(CHEBI:"withaferin A") decreases p(HGNC:MAPT) + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases a(CONSO:"huntingtin aggregates") - pmid:27181519 + pubmed:30362565 - a(CHEBI:"withaferin A") association bp(GO:autophagy) + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases bp(GO:"mRNA transcription") - pmid:29311797 + pubmed:30362565 - a(PUBCHEM:162859) decreases complex(p(FPLX:HSP90), p(HGNC:CDC37)) + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases bp(GO:"mRNA transcription") - pmid:29311797 + pubmed:30027901 - a(PUBCHEM:162859) causesNoChange act(p(FPLX:HSP90), ma(GO:"ATPase activity")) + act(p(HGNC:HTT, pmod(CONSO:"CAG repeats"))) decreases bp(GO:"mRNA transcription") - pmid:29311797 + pubmed:30362565 - a(PUBCHEM:4456430) decreases path(MESH:"Alzheimer Disease") + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases path(MESH:"Energy Metabolism") - pmid:29311797 + pubmed:30362565 - a(HBP:"KU-177") decreases act(p(HGNC:AHSA1)) + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases path(MESH:"Oxidative Stress") - pmid:29311797 + pubmed:30362565 - a(HBP:"KU-177") decreases p(HGNC:MAPT, var("p.Pro301Leu")) + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases path(MESH:"Oxidative Stress") - pmid:26751493 + pubmed:30362565 - p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation path(MESH:"Frontotemporal Dementia") + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases path(MESH:"Organelle Biogenesis") - pmid:23294633 + pubmed:30362565 - p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation path(MESH:"Frontotemporal Dementia") + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases path(MESH:"Mitochondrial Dynamics") - pmid:26631930 + pubmed:21861815 - p(HGNC:MAPT, var("p.Pro301Leu")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) negativeCorrelation path(MESH:"Mitochondrial Dynamics") - pmid:26631930 + pubmed:30362565 - p(HGNC:MAPT, var("p.Pro301Leu")) increases a(HBP:"Tau aggregates") + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases bp(GO:"metabolic process") - pmid:26631930 + pubmed:30362565 - p(HGNC:MAPT, var("p.Pro301Leu")) increases a(HBP:"Tau aggregates") + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases act(p(HGNCGENEFAMILY:"Pyruvate dehydrogenase complex")) - pmid:26631930 + pubmed:30362565 - p(HGNC:MAPT, var("p.Pro301Leu")) increases bp(GO:memory) + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases path(MESH:"Lipid Metabolism") - pmid:29121589 + pubmed:22179319 - p(HGNC:MAPT, var("p.Pro301Leu")) increases r(MGI:Il1b) + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases path(CONSO:neurotoxicity) - pmid:29121589 + pubmed:22179319 - p(HGNC:MAPT, var("p.Pro301Leu")) increases r(MGI:Nos2) + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) association path(MESH:Eating) - pmid:23294633 + pubmed:22179319 - p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(MGI:Gsk3b, pmod(Ph, Tyr, 279)) + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases path(MESH:Neuroprotection) - pmid:23294633 + pubmed:22179319 - p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(MGI:Gsk3b, pmod(Ph, Tyr, 216)) + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases p(HGNC:NTRK2, pmod(go:0006468 ! "protein phosphorylation")) - pmid:23294633 + pubmed:22179319 - p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases p(HGNC:NTRK2) - pmid:23294633 + pubmed:22179319 - p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 205)) + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases p(HGNC:FOXO3) - pmid:23294633 + pubmed:22179319 - p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 212)) + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases p(HGNC:FOXO3, pmod(go:0006473 ! "protein acetylation")) - pmid:23294633 + pubmed:22179319 - p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Thr, 214)) + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases p(HGNC:TP53, pmod(go:0006473 ! "protein acetylation", Lys, 382)) - pmid:23294633 + pubmed:22179319 - p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422)) + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) association p(HGNC:SIRT1, pmod(go:0006473 ! "protein acetylation")) - pmid:11606569 + pubmed:20556492 - p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HBP:"VQIINK motif") + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) - pmid:11606569 + pubmed:20556492 - p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation p(HBP:"VQIVYK motif") + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases tloc(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits"), fromLoc(GO:cytoplasm), toLoc(GO:"plasma membrane")) + + + + + + + + - pmid:27716675 + pubmed:20556492 - p(HGNC:MAPT, var("p.Pro301Leu")) positiveCorrelation path(HBP:neuroinflammation) + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases path(MESH:"Cytotoxicity, Immunologic") - pmid:26751493 + pubmed:20556492 - r(MGI:Mapt) partOf a(CL:0000127) + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases r(HGNC:PPARGC1A) - pmid:26751493 + pubmed:30027901 - r(MGI:Mapt) partOf a(CL:0000128) + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases path(MESH:"Huntington Disease") + + - pmid:26751493 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph, Ser, 68)) positiveCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNC:HTT, pmod(CONSO:"CAG repeats"))) increases bp(MESH:"Oxidative Stress") - pmid:26751493 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph, Thr, 69)) positiveCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNC:HTT, pmod(CONSO:"CAG repeats"))) increases bp(GO:autophagy) - pmid:26751493 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph, Thr, 71)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases bp(GO:autophagy) - pmid:26751493 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph, Ser, 113)) positiveCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNC:HTT, pmod(CONSO:"CAG repeats"))) increases bp(CONSO:"protein aggregation") - pmid:26751493 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph, Thr, 123)) positiveCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNC:HTT, pmod(CONSO:"CAG repeats"))) decreases bp(GO:"cellular homeostasis") - pmid:26751493 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph, Thr, 153)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases bp(GO:"cell death") - pmid:26751493 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph, Thr, 175)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) regulates bp(GO:"cell death") - pmid:26751493 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph, Thr, 184)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases p(INTERPRO:"Pathogenicity locus") - pmid:26751493 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph, Ser, 185)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases a(GO:"inclusion body", loc(MESH:Neurons)) + + - pmid:26751493 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph, Ser, 191)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases complex(p(HGNC:HTT, pmod(CONSO:"CAG repeats")), p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination"))) - pmid:26751493 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph, Tyr, 197)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) regulates bp(MESH:"Cell Survival") - pmid:23088643 + pubmed:23393546 - p(HGNC:MAPT, pmod(Ph, Tyr, 197)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases bp(MESH:"Cell Survival") - pmid:16566606 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph, Tyr, 197)) positiveCorrelation a(GO:microtubule) + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases bp(MESH:Apoptosis) - pmid:26751493 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph, Ser, 210)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases bp(GO:"nuclear pore complex assembly") - pmid:26751493 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph, Ser, 214)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases tloc(a(MESH:Autophagosomes), fromLoc(GO:"distal axon"), toLoc(GO:"cell body")) - pmid:8226987 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph, Ser, 214)) decreases complex(a(MESH:Microtubules), p(HGNC:MAPT)) + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases p(HGNC:MTOR) - pmid:26751493 + pubmed:26968346 - p(HGNC:MAPT, pmod(Ph, Ser, 237)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases p(HGNC:MTOR) - pmid:26751493 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph, Ser, 238)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases bp(CONSO:Proteostasis) - pmid:26751493 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph, Ser, 258)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases p(MESH:"HSP70 Heat-Shock Proteins") - pmid:26751493 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph, Ser, 289)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) causesNoChange p(MESH:"HSP70 Heat-Shock Proteins") - pmid:26751493 + pubmed:23393546 - p(HGNC:MAPT, pmod(Ph, Tyr, 394)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases bp(GO:"ERK1 and ERK2 cascade") - pmid:26631930 + pubmed:23393546 - p(HGNC:MAPT, pmod(Ph, Tyr, 394)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases p(HGNC:NF2) - pmid:26631930 + pubmed:23393546 - p(HGNC:MAPT, pmod(Ph, Tyr, 394)) association a(HBP:"paired helical filaments") + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases bp(GO:"MAPK cascade") - pmid:16566606 + pubmed:23393546 - p(HGNC:MAPT, pmod(Ph, Tyr, 394)) negativeCorrelation act(p(HGNC:MAPT)) + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases bp(GO:"MAPK cascade") - pmid:16566606 + pubmed:23393546 - p(HGNC:MAPT, pmod(Ph, Tyr, 394)) positiveCorrelation a(GO:microtubule) + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases bp(GO:"motor behavior") - pmid:26751493 + pubmed:23393546 - p(HGNC:MAPT, pmod(Ph, Thr, 403)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases path(CONSO:Neurodegeneration) - pmid:26751493 + pubmed:23393546 - p(HGNC:MAPT, pmod(Ph, Ser, 409)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases path(MESH:"Striatal Degeneration, Autosomal Dominant") - pmid:26751493 + pubmed:23393546 - p(HGNC:MAPT, pmod(Ph, Ser, 435)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases p(HGNC:PPP1R1B) - pmid:26751493 + pubmed:26968346 - p(HGNC:MAPT, pmod(Ph, Thr, 427)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) increases p(HGNC:BECN1) - pmid:26751493 + pubmed:27299292 - p(HGNC:MAPT, pmod(Ph, Ser, 433)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:HTT, pmod(CONSO:"CAG repeats")) decreases r(HGNC:TFEB) - pmid:26751493 + pubmed:30515821 - p(HBP:"microtubule-binding region") association p(HGNC:HDAC6) + complex(p(HGNC:DNM1L, var("p.Lys38Ala")), p(HGNC:HTT, pmod(CONSO:"CAG repeats"))) positiveCorrelation path(MESH:"Mitochondrial Dynamics") - pmid:26751493 + pubmed:30515821 - p(HBP:"microtubule-binding region") association p(HGNC:HDAC6) + complex(p(HGNC:DNM1L, var("p.Lys38Ala")), p(HGNC:HTT, pmod(CONSO:"CAG repeats"))) positiveCorrelation bp(GO:"axonal transport") - pmid:26751493 + pubmed:30515821 - p(HBP:"microtubule-binding region") partOf p(HGNC:MAPT) + complex(p(HGNC:DNM1L, var("p.Lys38Ala")), p(HGNC:HTT, pmod(CONSO:"CAG repeats"))) decreases bp(GO:"neuron death") + + - pmid:10464280 + pubmed:30515821 - p(HBP:"microtubule-binding region") isA p(HGNC:MAPT) + p(NCBIGENE:15194, pmod(CONSO:"CAG repeats")) increases a(CHEBI:"nitric oxide") - pmid:10537045 + pubmed:30515821 - p(HBP:"microtubule-binding region") partOf p(HGNC:MAPT) + p(NCBIGENE:15194, pmod(CONSO:"CAG repeats")) increases p(NCBIGENE:74006, pmod(go:0017014 ! "protein nitrosylation")) - pmid:26751493 + pubmed:30515821 - p(HBP:"microtubule-binding region") partOf p(HGNC:MAPT) + p(NCBIGENE:74006, pmod(go:0017014 ! "protein nitrosylation")) increases bp(GO:"mitochondrial fission") - pmid:10464280 + pubmed:30515821 - p(HBP:"microtubule-binding region") association act(complex(GO:"protein phosphatase type 2A complex")) + p(NCBIGENE:74006, pmod(go:0017014 ! "protein nitrosylation")) increases bp(GO:"neuron death") - pmid:10464280 + pubmed:30515821 - p(HBP:"microtubule-binding region") positiveCorrelation act(complex(GO:microtubule)) + p(HGNC:DNM1L, pmod(go:0017014 ! "protein nitrosylation")) increases bp(GO:"mitochondrial fission") - pmid:18500754 + pubmed:30515821 - p(HBP:"microtubule-binding region") association p(HGNC:HSPA8) + p(HGNC:DNM1L, pmod(go:0017014 ! "protein nitrosylation")) increases bp(GO:"neuron death") - pmid:18500754 + pubmed:30515821 - p(HBP:"microtubule-binding region") association p(INTERPRO:"Heat shock protein 70kD, C-terminal domain superfamily") + p(HGNC:DNM1L, pmod(go:0017014 ! "protein nitrosylation")) increases complex(p(HGNC:DNM1L), p(HGNC:HTT, pmod(CONSO:"CAG repeats"))) - pmid:8391280 + pubmed:30515821 - p(HBP:"microtubule-binding region") association p(FPLX:Ubiquitin) + p(HGNC:DNM1L, pmod(go:0017014 ! "protein nitrosylation")) increases path(MESH:"Wounds and Injuries") - pmid:10537045 + pubmed:30515821 - p(HBP:"microtubule-binding region") association act(p(HGNC:TGM2)) + p(HGNC:DNM1L, var("p.Cys644Ala")) decreases bp(GO:"mitochondrial fission") - pmid:26751493 + pubmed:30515821 - p(HBP:"tubulin-binding repeat 1") association g(HBP:"APOE e3") + p(HGNC:DNM1L, var("p.Cys644Ala")) decreases path(MESH:"Wounds and Injuries") - pmid:26751493 + pubmed:30515821 - p(HBP:"tubulin-binding repeat 1") association g(HBP:"APOE e3") + p(HGNC:DNM1L, var("p.Cys644Ala")) positiveCorrelation path(MESH:"Mitochondrial Dynamics") - pmid:26751493 + pubmed:30515821 - p(HBP:"tubulin-binding repeat 1") partOf p(HBP:"microtubule-binding region") + complex(p(HGNC:DNM1L), p(HGNC:MAPK1)) increases p(HGNC:DNM1L, pmod(go:0006468 ! "protein phosphorylation", Ser, 616)) - pmid:26751493 + pubmed:30688256 - p(HBP:"tubulin-binding repeat 1") partOf p(HBP:"microtubule-binding region") + bp(GO:"mitochondrial depolarization") increases p(HGNC:PINK1, loc(GO:"mitochondrial inner membrane")) - pmid:17493042 + pubmed:21722302 - p(HBP:"tubulin-binding repeat 1") partOf a(HBP:"microtubule-binding region") + bp(GO:"mitochondrial depolarization") increases p(HGNC:PINK1) - pmid:17493042 + pubmed:30562574 - p(HBP:"tubulin-binding repeat 1") equivalentTo p(HBP:"Tau isoform F (441 aa)", frag("244_274")) + bp(GO:"mitochondrial depolarization") association p(HGNC:PARK7) - pmid:23407988 + pubmed:30515821 - p(HBP:"tubulin-binding repeat 1") partOf p(HBP:"4R tau") + bp(NCIT:C17741) increases path(DOID:"motor neuron disease") - pmid:23407988 + pubmed:30515821 - p(HBP:"tubulin-binding repeat 1") partOf p(HBP:"3R tau") + path(DOID:"motor neuron disease") negativeCorrelation bp(MESH:"Energy Metabolism") - pmid:26751493 + pubmed:27181519 - g(HBP:"APOE e3") association p(HBP:"tubulin-binding repeat 1") + path(DOID:"motor neuron disease") association p(HGNC:FUS) - pmid:26751493 + pubmed:28669544 - g(HBP:"APOE e3") association p(HBP:"tubulin-binding repeat 1") + path(DOID:"motor neuron disease") increases composite(a(MESH:Microglia), p(HGNC:TARDBP)) - pmid:26751493 + pubmed:30515821 - p(HBP:"projection domain") association p(HGNC:LCK) + p(HGNC:TAT, frag("47_57")) decreases complex(p(HGNC:DNM1L), p(HGNC:FIS1)) - pmid:26751493 + pubmed:30515821 - p(HBP:"projection domain") association p(HGNC:FGR) + p(HGNC:TAT, frag("47_57")) causesNoChange bp(GO:"mitochondrial fission") - pmid:26751493 + pubmed:30515821 - p(HBP:"projection domain") association p(HGNC:SRC) + p(HGNC:TAT, frag("47_57")) decreases a(CHEBI:"reactive oxygen species") - pmid:26751493 + pubmed:30515821 - p(HBP:"projection domain") association p(HGNC:GRB2) + p(HGNC:TAT, frag("47_57")) decreases bp(GO:"neuron death") - pmid:26751493 + pubmed:30515821 - p(HBP:"projection domain") association p(FPLX:PLC) + p(HGNC:TAT, frag("47_57")) decreases path(DOID:"muscular atrophy") - pmid:26751493 + pubmed:30515821 - p(HBP:"projection domain") association a(CHEBI:phosphatidylinositol) + p(HGNC:TAT, frag("47_57")) decreases path(DOID:"amyotrophic lateral sclerosis") + + - pmid:26751493 + pubmed:19126755 - p(HBP:"projection domain") association a(CHEBI:"phosphatidylinositol bisphosphate") + act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) regulates p(FPLX:PLC) - pmid:26751493 + pubmed:19126755 - p(HBP:"projection domain") association p(HGNC:PIN1) + act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) regulates a(CHEBI:"3',5'-cyclic AMP") - pmid:26751493 + pubmed:19126755 - p(HBP:"projection domain") partOf p(HGNC:MAPT) + act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) regulates a(CHEBI:"myo-inositol trisphosphate") - pmid:26751493 + pubmed:19126755 - p(HBP:"projection domain") association p(HGNC:FYN) + act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) regulates a(CHEBI:"calcium ion") - pmid:26751493 + pubmed:24511233 - p(HBP:"projection domain") association p(HGNC:DLG4) + p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") regulates act(a(CHEBI:acetylcholine)) - pmid:26751493 + pubmed:19721446 - p(HBP:"projection domain") association a(MESH:"Receptors, N-Methyl-D-Aspartate") + p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") increases act(a(CHEBI:acetylcholine)) - pmid:26751493 + pubmed:24511233 - p(HBP:"projection domain") association p(MESH:"Receptors, N-Methyl-D-Aspartate") + p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") isA p(MESH:"Receptors, G-Protein-Coupled") - pmid:26751493 + pubmed:24511233 - p(HGNC:FGR) association p(HBP:"projection domain") + p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") regulates bp(GO:cognition) - pmid:26751493 + pubmed:24590577 - p(HGNC:GRB2) association p(HBP:"projection domain") + p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association path(MESH:"Alzheimer Disease") @@ -145722,726 +147466,731 @@

Statements

- pmid:26751493 + pubmed:24590577 - a(CHEBI:"phosphatidylinositol bisphosphate") association p(HBP:"projection domain") + p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association bp(GO:memory) - pmid:26751493 + pubmed:24590577 - path(HBP:"Corticobasal Degeneration") positiveCorrelation p(HBP:"4R tau") + p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association path(MESH:Attention) - pmid:26631930 + pubmed:24590577 - path(HBP:"Corticobasal Degeneration") positiveCorrelation p(HBP:"4R tau") + p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association path(MESH:Nociception) - pmid:22057784 + pubmed:24590577 - path(HBP:"Corticobasal Degeneration") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) + p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association bp(GO:"circadian sleep/wake cycle") - pmid:17050703 + pubmed:24590577 - path(HBP:"Corticobasal Degeneration") association p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) + p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association a(MESH:"Cardiovascular System") - pmid:21427723 + pubmed:24590577 - path(HBP:"Corticobasal Degeneration") positiveCorrelation p(HGNC:MAPT, pmod(Ac, Lys, 280)) + p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association a(MESH:Kidney) - pmid:21427723 + pubmed:24590577 - path(HBP:"Corticobasal Degeneration") isA path(HBP:"4R tauopathy") + p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") association a(MESH:"Gastrointestinal Tract") - pmid:26751493 + pubmed:19126755 - path(HBP:"Argyrophilic Grain Disease") positiveCorrelation p(HBP:"4R tau") + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Electric Fish") - - - pmid:26751493 - - p(HGNC:MAPT, var("p.Val337Met")) positiveCorrelation path(MESH:"Frontotemporal Dementia") - + + + + + + + - pmid:26631930 + pubmed:19126755 - p(HGNC:MAPT, var("p.Val337Met")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") increases tloc(a(CHEBI:"gamma-aminobutyric acid"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:26631930 + pubmed:19721446 - p(HGNC:MAPT, var("p.Val337Met")) increases a(HBP:"Tau aggregates") + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases tloc(a(CHEBI:"gamma-aminobutyric acid"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:26751493 + pubmed:19126755 - p(HGNC:MAPT, var("p.Gly272Val")) positiveCorrelation path(MESH:"Frontotemporal Dementia") + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) regulates bp(GO:"synaptic transmission, dopaminergic") - pmid:26631930 + pubmed:19126755 - p(HGNC:MAPT, var("p.Gly272Val")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:26631930 + pubmed:19126755 - p(HGNC:MAPT, var("p.Gly272Val")) increases a(HBP:"Tau aggregates") + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:26631930 + pubmed:19126755 - p(HGNC:MAPT, var("p.Gly272Val")) decreases p(HBP:"4R tau") + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:26631930 + pubmed:19293145 - p(HGNC:MAPT, var("p.Gly272Val")) increases p(HBP:"3R tau") + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association path(MESH:"Alzheimer Disease") - pmid:26751493 + pubmed:19126755 - p(HGNC:MAPT, var("p.Arg406Trp")) positiveCorrelation path(MESH:"Frontotemporal Dementia") + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) negativeCorrelation path(MESH:Schizophrenia) - pmid:26631930 + pubmed:19126755 - p(HGNC:MAPT, var("p.Arg406Trp")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) negativeCorrelation a(CHEBI:"kynurenic acid") - pmid:26631930 + pubmed:19126755 - p(HGNC:MAPT, var("p.Arg406Trp")) increases a(HBP:"Tau aggregates") + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association a(CHEBI:"amyloid-beta polypeptide 42") - pmid:26751493 + pubmed:19126755 - p(HGNC:PSEN1, var("p.Gly183Val")) positiveCorrelation path(MESH:"Frontotemporal Dementia") + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association a(CHEBI:anandamide) - pmid:26751493 + pubmed:19126755 - p(HGNC:PSEN1, var("p.Gly183Val")) positiveCorrelation path(MESH:"Niemann-Pick Diseases") + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(CHEBI:anandamide) - pmid:26751493 + pubmed:19126755 - p(HGNC:PSEN1, var("p.Gly183Val")) causesNoChange a(CHEBI:"amyloid-beta") + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases bp(GO:"cation transport") - pmid:26751493 + pubmed:19126755 - g(DBSNP:rs2471738) association path(MESH:"Parkinson Disease") + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases a(MESH:Sodium, loc(GO:intracellular)) - pmid:26751493 + pubmed:19126755 - g(DBSNP:rs242557) association path(MESH:"Parkinson Disease") + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases bp(GO:"membrane depolarization") - pmid:26751493 + pubmed:19126755 - p(HGNC:MAPT, var("p.Glu391*")) association p(HBP:"paired helical filaments") + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases bp(GO:"positive regulation of voltage-gated calcium channel activity") - pmid:25974414 + pubmed:19126755 - p(HGNC:MAPT, var("p.Glu391*")) partOf a(GO:"neurofibrillary tangle") + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases a(CHEBI:"calcium(2+)", loc(GO:intracellular)) - pmid:25974414 + pubmed:29428175 - p(HGNC:MAPT, var("p.Glu391*")) positiveCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(GO:"endoplasmic reticulum"), toLoc(MESH:Cytoplasm)) - pmid:25974414 + pubmed:19126755 - p(HGNC:MAPT, var("p.Glu391*")) isA p(HGNC:MAPT) + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") regulates bp(GO:"inflammatory response") - pmid:22002427 + pubmed:19126755 - p(HGNC:MAPT, var("p.Glu391*")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) decreases bp(GO:"keratinocyte migration") - pmid:22002427 + pubmed:19126755 - p(HGNC:MAPT, var("p.Glu391*")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 205)) + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) regulates bp(GO:"phosphatidylinositol 3-kinase signaling") - pmid:26751493 + pubmed:19126755 - p(HBP:"paired helical filaments") association p(HGNC:MAPT, var("p.Glu391*")) + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) regulates bp(GO:"ERK1 and ERK2 cascade") - pmid:26751493 + pubmed:19126755 - p(HBP:"paired helical filaments") partOf a(GO:"neurofibrillary tangle") + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) regulates bp(GO:"receptor signaling pathway via JAK-STAT") - pmid:26751493 + pubmed:19126755 - p(HGNC:SNAP25) negativeCorrelation a(GO:"neurofibrillary tangle") + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Mice, Inbred Strains") - - - pmid:26751493 + pubmed:19126755 - p(PFAM:Syntaxin) negativeCorrelation a(GO:"neurofibrillary tangle") + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Mice, Inbred Strains") - - - - - pmid:26751493 + pubmed:19126755 - complex(a(CHEBI:heparin), p(HBP:"Tau aggregates")) positiveCorrelation bp(GO:macropinocytosis) + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Rats, Inbred Strains") - pmid:26751493 + pubmed:19126755 - complex(a(CHEBI:heparin), p(HBP:"Tau aggregates")) association bp(GO:macropinocytosis) + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") negativeCorrelation path(MESH:Aging) - pmid:26751493 + pubmed:19293145 - bp(GO:"cell-cell signaling via exosome") isA tloc(a(HBP:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(CHEBI:amyloid-beta) - pmid:26751493 + pubmed:19293145 - a(CL:0000129) increases tloc(a(HBP:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") decreases act(a(CHEBI:amyloid-beta)) - pmid:26751493 + pubmed:19293145 - a(CHEBI:"trans-5-O-caffeoyl-D-quinic acid") decreases act(p(HGNC:PPME1)) + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(CHEBI:amyloid-beta) - pmid:26751493 + pubmed:19293145 - a(CHEBI:"trans-5-O-caffeoyl-D-quinic acid") increases bp(GO:cognition) + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") regulates tloc(a(CHEBI:amyloid-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:26751493 + pubmed:19293145 - a(CHEBI:"trans-5-O-caffeoyl-D-quinic acid") increases bp(GO:"motor behavior") + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") regulates act(a(CHEBI:amyloid-beta)) - pmid:26751493 + pubmed:19293145 - a(CHEBI:"trans-5-O-caffeoyl-D-quinic acid") decreases act(p(MGI:Ppme1)) + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") increases act(a(CHEBI:amyloid-beta)) - pmid:26751493 + pubmed:19293145 - p(HBP:"Tau antibody, RG7345") decreases p(HGNC:MAPT, pmod(Ph, Ser, 422)) + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association a(CHEBI:amyloid-beta) - pmid:26751493 + pubmed:19293145 - a(CHEBI:"azure A") increases bp(GO:"protein catabolic process") + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") decreases path(CONSO:neurotoxicity) - pmid:26751493 + pubmed:19293145 - a(CHEBI:"azure A") association bp(GO:"response to oxidative stress") + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association path(CONSO:neurotoxicity) - pmid:26751493 + pubmed:19293145 - a(CHEBI:"azure A") decreases act(p(HGNC:CASP1)) + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(CHEBI:nicotine) + + - pmid:26751493 + pubmed:19293145 - a(CHEBI:"azure A") decreases act(p(HGNC:CASP3)) + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) decreases act(a(CHEBI:N-methyl-4-phenylpyridinium)) - pmid:26751493 + pubmed:19293145 - a(CHEBI:"azure B") increases bp(GO:"protein catabolic process") + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") increases bp(MESH:Neuroprotection) - pmid:26751493 + pubmed:19293145 - a(CHEBI:"azure B") association bp(GO:"response to oxidative stress") + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases act(p(FPLX:PI3K)) - pmid:26751493 + pubmed:19293145 - a(CHEBI:"azure B") decreases act(p(HGNC:CASP1)) + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association p(HGNC:JAK2) - pmid:26751493 + pubmed:19293145 - a(CHEBI:"azure B") decreases act(p(HGNC:CASP3)) + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association bp(GO:"calcium ion homeostasis") + + - pmid:26751493 + pubmed:19293145 - p(HGNC:MAPT, pmod(Ac, Lys, 274)) increases p(HBP:"Tau aggregates") + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association g(HGNC:APOE) - pmid:26751493 + pubmed:19293145 - p(HGNC:MAPT, pmod(Ac, Lys, 274)) positiveCorrelation p(HBP:"Tau aggregates") + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association p(HGNC:APOE) - pmid:27041503 + pubmed:19293145 - p(HGNC:MAPT, pmod(Ac, Lys, 274)) decreases bp(GO:memory) + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases tloc(p(CONSO:sAPP-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:27041503 + pubmed:19293145 - p(HGNC:MAPT, pmod(Ac, Lys, 274)) decreases bp(GO:"regulation of synaptic plasticity") + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association bp(GO:"apoptotic process") - pmid:27041503 + pubmed:19293145 - p(HGNC:MAPT, pmod(Ac, Lys, 274)) decreases p(HGNC:WWC1) + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:26751493 + pubmed:24511233 - a(HBP:thiohydantoin) decreases p(HBP:"Tau aggregates") + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") regulates act(a(CHEBI:acetylcholine)) - pmid:26751493 + pubmed:19721446 - a(HBP:oxazolidinedione) decreases p(HBP:"Tau aggregates") + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") increases act(a(CHEBI:acetylcholine)) - pmid:26751493 + pubmed:22530628 - a(HBP:thioxooxazolidine) decreases p(HBP:"Tau aggregates") + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) negativeCorrelation path(MESH:"Memory Disorders") - pmid:26751493 + pubmed:22530628 - a(CHEBI:thiostrepton) decreases p(HBP:"Tau aggregates") + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association path(MESH:Attention) - pmid:26751493 + pubmed:22530628 - a(HBP:sudoxicam) decreases p(HBP:"Tau aggregates") + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association bp(GO:memory) + + - pmid:26751493 + pubmed:29428175 - a(CHEBI:isoniazide) decreases p(HBP:"Tau aggregates") + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association bp(GO:"synaptic signaling") - pmid:26751493 + pubmed:29428175 - a(CHEBI:Iproniazid) decreases p(HBP:"Tau aggregates") + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association bp(GO:"learning or memory") - pmid:26751493 + pubmed:30697142 - a(CHEBI:iproclozide) decreases p(HBP:"Tau aggregates") + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") regulates bp(GO:"learning or memory") - pmid:26751493 + pubmed:29428175 - a(HBP:isocarboxazide) decreases p(HBP:"Tau aggregates") + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association path(MESH:"Substance-Related Disorders") - pmid:26751493 + pubmed:29428175 - a(CHEBI:myricetin) decreases p(HBP:"Tau aggregates") + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association path(DOID:schizophrenia) - pmid:26751493 + pubmed:29428175 - a(CHEBI:emodin) decreases p(HBP:"Tau aggregates") + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association path(DOID:"Alzheimer's disease") - pmid:26751493 + pubmed:29428175 - a(CHEBI:daunorubicin) decreases p(HBP:"Tau aggregates") + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") regulates tloc(a(MESH:Cytokines), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:26751493 + pubmed:29428175 - a(CHEBI:doxorubicin) decreases p(HBP:"Tau aggregates") + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association bp(MESH:"Immunity, Cellular") - pmid:26751493 + pubmed:29428175 - a(CHEBI:quinalizarin) decreases p(HBP:"Tau aggregates") + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association path(MESH:"Immune System Diseases") - pmid:26458742 + pubmed:29428175 - p(HBP:"Tau isoform D (383 aa)", pmod(Ph, Thr, 205)) positiveCorrelation p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")) + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association path(MESH:Inflammation) - pmid:26458742 + pubmed:30697142 - p(HBP:"Tau isoform D (383 aa)", pmod(Ph, Ser, 262)) positiveCorrelation p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")) + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") increases bp(MESH:Metabolism) + + + + - pmid:26458742 + pubmed:19721446 - p(HBP:"Tau isoform D (383 aa)", pmod(Ph, Ser, 400)) positiveCorrelation p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")) + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Peripheral Nervous System") - pmid:26458742 + pubmed:19721446 - p(HBP:"Tau isoform D (383 aa)", pmod(Ph, Ser, 404)) positiveCorrelation p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")) + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") association a(MESH:"Central Nervous System") - pmid:26458742 + pubmed:19721446 - p(HBP:"Tau isoform D (383 aa)", pmod(Ph, Ser, 409)) positiveCorrelation p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")) + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:26458742 + pubmed:19721446 - p(HBP:"Tau isoform D (383 aa)", pmod(Ph, Ser, 422)) positiveCorrelation p(HBP:"Tau isoform D (383 aa)", var("p.Pro301Leu")) + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases tloc(a(CHEBI:serotonin), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:26195256 + pubmed:19721446 - act(a(HBP:"Glymphatic System")) decreases a(CHEBI:"amyloid-beta", loc(GO:"extracellular region")) + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases tloc(a(CHEBI:"glutamate(2-)"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:26195256 + pubmed:19721446 - act(a(HBP:"Glymphatic System")) decreases a(CHEBI:"amyloid-beta", loc(GO:"extracellular region")) + act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association a(CHEBI:cholesterol) - pmid:26195256 + pubmed:19721446 - act(a(HBP:"Glymphatic System")) decreases a(CHEBI:"amyloid-beta") + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") regulates bp(MESH:"Sensory Gating") - pmid:26195256 + pubmed:19126755 - p(HGNC:CLU, var("?")) association path(MESH:"Alzheimer Disease") + a(CHEBI:Muscarine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) @@ -146450,622 +148199,603 @@

Statements

- pmid:26195256 + pubmed:19126755 - path(MESH:"Craniocerebral Trauma") increases path(MESH:"Alzheimer Disease") + a(CHEBI:atropine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) - pmid:26195256 + pubmed:19126755 - bp(MESH:Exercise) decreases path(MESH:"Alzheimer Disease") + a(CHEBI:atropine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) - pmid:26195256 + pubmed:19126755 - path(MESH:"Sleep Initiation and Maintenance Disorders") increases path(MESH:"Alzheimer Disease") + a(CHEBI:atropine) decreases bp(GO:"cell adhesion") - pmid:26195256 + pubmed:26813123 - path(MESH:"Sleep Initiation and Maintenance Disorders") increases path(MESH:"Alzheimer Disease") + a(CHEBI:atropine) decreases act(p(FPLX:CHRM)) - pmid:26195256 + pubmed:26751493 - a(MESH:"Cerebral Ventricles") positiveCorrelation path(MESH:"Alzheimer Disease") + p(FPLX:PLC) association p(CONSO:"projection domain") - - - pmid:26195256 - - path(MESH:"Cerebral Amyloid Angiopathy") association a(HBP:"amyloid-beta aggregates") - + - pmid:26195256 + pubmed:30697142 - path(MESH:"Cerebral Amyloid Angiopathy") negativeCorrelation bp(HBP:"perivascular drainage pathways") + a(CHEBI:"3',5'-cyclic AMP") increases a(CHEBI:"glutamate(2-)") - pmid:26195256 + pubmed:20556492 - p(MESH:Endopeptidases) increases bp(GO:"protein catabolic process") + a(CHEBI:"3',5'-cyclic AMP") increases act(p(HGNC:CREBBP), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) - pmid:26195256 + pubmed:23393546 - p(MESH:Endopeptidases) increases deg(a(CHEBI:"amyloid-beta", loc(GO:intracellular))) + a(CHEBI:"3',5'-cyclic AMP") regulates p(HGNC:PPP1R1B) - - - - - pmid:26195256 + pubmed:29626319 - act(complex(a(MESH:Endosomes), a(MESH:Lysosomes))) increases bp(GO:"protein catabolic process") + a(CHEBI:"3',5'-cyclic AMP") increases deg(p(HGNC:MAPT)) - pmid:26195256 + pubmed:27190210 - act(p(MESH:"Amyloid Precursor Protein Secretases")) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"), a(HBP:"APP C-terminally truncated carboxyl-terminal fragments"))) + a(CHEBI:"calcium ion") regulates p(HGNC:CHRNA7) - - - - - pmid:26195256 + pubmed:29428175 - a(HBP:"amyloid-beta polypeptide 38") isA a(CHEBI:"amyloid-beta") + a(CHEBI:"calcium ion", loc(MESH:Cytoplasm)) regulates bp(GO:"cell differentiation") - pmid:26195256 + pubmed:29428175 - act(p(MESH:Cathepsins)) increases deg(a(CHEBI:"amyloid-beta", loc(GO:intracellular))) + a(CHEBI:"calcium ion", loc(MESH:Cytoplasm)) regulates bp(GO:"cell migration") - pmid:26195256 + pubmed:29428175 - p(HGNC:MMP3) increases deg(a(CHEBI:"amyloid-beta", loc(GO:"extracellular region"))) + a(CHEBI:"calcium ion", loc(MESH:Cytoplasm)) regulates bp(GO:"synapse assembly") - pmid:29626319 + pubmed:29428175 - act(p(HGNC:MMP3)) increases deg(a(CHEBI:"amyloid-beta")) + a(CHEBI:"calcium ion", loc(MESH:Cytoplasm)) regulates a(GO:cytoskeleton) - pmid:26195256 + pubmed:29428175 - p(HGNC:ECE1) increases deg(a(CHEBI:"amyloid-beta", loc(GO:"extracellular region"))) + a(CHEBI:"calcium ion", loc(MESH:Cytoplasm)) regulates a(GO:cytoskeleton) - pmid:29626319 + pubmed:29428175 - p(HGNC:ECE1) increases deg(a(CHEBI:"amyloid-beta")) + a(CHEBI:"calcium ion", loc(MESH:Cytoplasm)) regulates act(p(HGNC:CAMK2B)) - pmid:26195256 + pubmed:29428175 - p(HGNC:ECE2) increases deg(a(CHEBI:"amyloid-beta", loc(GO:"extracellular region"))) + a(CHEBI:"calcium ion", loc(MESH:Cytoplasm)) decreases p(HGNCGENEFAMILY:Calpains) - pmid:26195256 + pubmed:29428175 - p(HGNC:PLAT) increases deg(a(CHEBI:"amyloid-beta", loc(GO:"extracellular region"))) + a(CHEBI:"calcium ion", loc(MESH:Cytoplasm)) decreases p(GO:spectrin) - pmid:26195256 + pubmed:29428175 - p(HGNC:ACE) increases deg(a(CHEBI:"amyloid-beta", loc(GO:"extracellular region"))) + a(CHEBI:"calcium ion", loc(MESH:Cytoplasm)) decreases bp(GO:"cytoskeleton organization") - pmid:29626319 + pubmed:26979166 - p(HGNC:ACE) increases deg(a(CHEBI:"amyloid-beta")) + tloc(a(CHEBI:"calcium ion"), fromLoc(GO:"pore complex"), toLoc(MESH:"Intracellular Space")) increases act(p(HGNCGENEFAMILY:"Ryanodine receptors")) - pmid:29626319 + pubmed:26979166 - p(HGNC:ACE) increases deg(a(CHEBI:"amyloid-beta")) + tloc(a(CHEBI:"calcium ion"), fromLoc(GO:"pore complex"), toLoc(MESH:"Intracellular Space")) increases act(p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors")) - pmid:29626319 + pubmed:30697142 - p(HGNC:ACE) increases rxn(reactants(a(CHEBI:"Angiotensin I")), products(a(CHEBI:"angiotensin II"))) + a(CHEBI:"calcium ion") increases a(CHEBI:"glutamate(2-)") - pmid:29626319 + pubmed:30697142 - p(HGNC:ACE) regulates a(MESH:"Body Fluids") + a(CHEBI:"calcium ion") increases a(CHEBI:"3',5'-cyclic AMP") - pmid:29626319 + pubmed:29758300 - p(HGNC:ACE) regulates bp(MESH:"Blood Pressure") + a(CHEBI:"calcium ion") increases act(a(MESH:"Vacuolar Proton-Translocating ATPases")) - pmid:29626319 + pubmed:19126755 - p(HGNC:ACE) regulates bp(GO:"sodium ion transmembrane transport") + a(MESH:"Electric Fish") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:29626319 + pubmed:19126755 - act(p(HGNC:ACE)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(CONSO:alpha-Bungarotoxin) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + + - pmid:26195256 + pubmed:19126755 - a(MESH:"Muscle, Smooth, Vascular") increases deg(a(CHEBI:"amyloid-beta")) + p(CONSO:alpha-Bungarotoxin) increases complex(p(CONSO:alpha-Bungarotoxin), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:26195256 + pubmed:19126755 - p(MESH:Neprilysin) negativeCorrelation path(MESH:"Alzheimer Disease") + p(CONSO:alpha-Bungarotoxin) decreases a(CHEBI:dopamine, loc(GO:"extracellular region")) - - - pmid:26195256 - - p(HGNC:ABCB1) increases tloc(a(CHEBI:"amyloid-beta")) - + - pmid:26195256 + pubmed:27190210 - p(HGNC:ABCB1) increases tloc(a(CHEBI:"amyloid-beta")) + p(CONSO:alpha-Bungarotoxin) decreases p(HGNC:CHRNA7) - pmid:26195256 + pubmed:29428175 - p(HGNC:ABCB1) increases tloc(a(CHEBI:"amyloid-beta")) + p(CONSO:alpha-Bungarotoxin) decreases p(HGNC:CHRNA7) - pmid:29626319 + pubmed:29428175 - p(HGNC:ABCB1) increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:Brain), toLoc(GO:"extracellular region")) + p(CONSO:alpha-Bungarotoxin) negativeCorrelation bp(GO:"regulation of presynaptic membrane potential") - - - pmid:29626319 - - p(HGNC:ABCB1) decreases a(CHEBI:"amyloid-beta") - + + + - pmid:26195256 + pubmed:21482353 - p(HGNC:ABCB1) increases act(p(HGNC:APOE)) + p(CONSO:alpha-Bungarotoxin) decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + + - pmid:26195256 + pubmed:21958873 - p(HGNC:ABCB1) negativeCorrelation path(MESH:"Alzheimer Disease") + p(CONSO:alpha-Bungarotoxin) causesNoChange a(CHEBI:amyloid-beta) - pmid:26195256 + pubmed:21958873 - p(HGNC:A2M) decreases a(CHEBI:"amyloid-beta") + p(CONSO:alpha-Bungarotoxin) decreases act(a(MESH:"Receptors, Nicotinic")) - pmid:26195256 + pubmed:19126755 - p(HGNC:LRP2) decreases a(CHEBI:"amyloid-beta") + bp(GO:signaling) association a(CHEBI:acetylcholine) - pmid:26195256 + pubmed:19126755 - p(MESH:"ATP-Binding Cassette Transporters") increases tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:Brain)) + act(p(HGNC:CHAT)) directlyIncreases rxn(reactants(a(CHEBI:acetyl-CoA), a(CHEBI:choline)), products(a(CHEBI:acetylcholine))) - pmid:26195256 + pubmed:26813123 - act(p(HGNC:PPIA)) decreases bp(GO:"establishment of blood-brain barrier") + p(HGNC:CHAT) increases rxn(reactants(a(CHEBI:acetyl-CoA), a(CHEBI:choline)), products(a(CHEBI:acetylcholine))) - pmid:26195256 + pubmed:16273023 - bp(HBP:"perivascular drainage pathways") decreases a(CHEBI:"amyloid-beta") + act(p(HGNC:CHAT), ma(go:0003824 ! "catalytic activity")) increases rxn(reactants(a(CHEBI:acetyl-CoA), a(CHEBI:choline)), products(a(CHEBI:acetylcholine))) - pmid:26195256 + pubmed:19293145 - bp(HBP:"perivascular drainage pathways") negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:CHAT) negativeCorrelation g(HGNC:APOE) + + - pmid:26195256 + pubmed:26813123 - bp(HBP:"perivascular drainage pathways") negativeCorrelation path(MESH:"Cerebral Amyloid Angiopathy") + act(p(HGNC:CHAT)) negativeCorrelation path(MESH:"Huntington Disease") - pmid:26195256 + pubmed:26813123 - bp(HBP:"perivascular drainage pathways") negativeCorrelation p(HBP:"APOE e4") + act(p(HGNC:CHAT)) decreases path(MESH:Dementia) - pmid:26195256 + pubmed:24590577 - path(HBP:"high-fat prenatal maternal diet") decreases deg(a(CHEBI:"amyloid-beta")) + p(HGNC:CHAT) decreases a(CHEBI:acetylcholine) - pmid:26195256 + pubmed:25514383 - path(MESH:Sleep) increases act(a(MESH:"Blood-Brain Barrier")) + act(p(HGNC:CHAT)) increases a(CHEBI:acetylcholine) - pmid:26195256 + pubmed:18986241 - path(MESH:Sleep) decreases a(CHEBI:"amyloid-beta") + act(p(HGNC:CHAT)) directlyIncreases a(CHEBI:acetylcholine) - pmid:29626319 + pubmed:19721446 - path(MESH:Sleep) decreases a(CHEBI:"amyloid-beta") + p(HGNC:CHAT) increases a(CHEBI:acetylcholine) - pmid:26195256 + pubmed:18986241 - path(MESH:Sleep) increases bp(HBP:"glymphatic bulk flow") + act(p(HGNC:CHAT)) decreases path(CONSO:Neurodegeneration) - - - pmid:26195256 - - path(MESH:Sleep) increases p(HGNC:LRP1) - + + + - pmid:26195256 + pubmed:9089387 - a(MESH:"Cerebrospinal Fluid") negativeCorrelation path(MESH:Aging) + a(CHEBI:acetyl-CoA) increases a(CHEBI:acetylcholine) - pmid:26195256 + pubmed:28002468 - a(MESH:"Cerebrospinal Fluid") negativeCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:acetyl-CoA) increases bp(CONSO:"cystein-dependent auto-acetylation") - pmid:26195256 + pubmed:17009926 - act(p(HGNC:AQP1)) negativeCorrelation path(MESH:Aging) + a(CHEBI:choline) increases act(p(FPLX:CHRN)) - pmid:26195256 + pubmed:26813123 - act(p(HGNC:AQP1)) negativeCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:choline) increases a(CHEBI:acetylcholine) + + - pmid:26195256 + pubmed:29428175 - act(p(HGNC:AQP1)) increases a(MESH:"Cerebrospinal Fluid") + a(CHEBI:choline) increases act(p(HGNC:CHRNA7)) - - - pmid:26195256 - - act(p(HGNC:AQP1)) increases sec(a(CHEBI:water)) - + - pmid:29626319 + pubmed:26088141 - p(HGNC:AQP1) increases act(a(MESH:"Choroid Plexus")) + act(a(CHEBI:choline)) increases a(CHEBI:"calcium(2+)") - pmid:29626319 + pubmed:26088141 - p(HGNC:AQP1) decreases a(CHEBI:"amyloid-beta") + a(CHEBI:choline) increases a(CHEBI:"calcium(2+)") + + - pmid:26195256 + pubmed:26088141 - path(MESH:"Calcification, Physiologic") decreases a(MESH:"Cerebrospinal Fluid") + act(a(CHEBI:choline)) association act(a(MESH:"Calcium Channels")) - pmid:26195256 + pubmed:26088141 - path(MESH:Fibrosis) decreases a(MESH:"Cerebrospinal Fluid") + a(CHEBI:choline) association bp(MESH:"Pleckstrin Homology Domains") - pmid:26195256 + pubmed:26088141 - act(p(MESH:Lysosomes)) increases deg(p(HGNC:MAPT)) + a(CHEBI:choline) increases bp(MESH:"Pleckstrin Homology Domains") - pmid:26195256 + pubmed:26088141 - act(p(MESH:Calpain)) increases deg(p(HGNC:MAPT)) + a(CHEBI:choline) decreases complex(p(FPLX:"G_protein"), p(HGNC:CHRNA7)) - pmid:26195256 + pubmed:26088141 - p(HBP:"tau aggregates") association path(MESH:"Brain Injuries, Traumatic") + a(CHEBI:choline) decreases complex(p(HGNC:CHRNA7), p(HGNC:GNAQ)) - pmid:26195256 + pubmed:26088141 - p(HBP:"tau aggregates") increases path(MESH:"Neurodegenerative Diseases") + a(CHEBI:choline) decreases complex(p(HGNC:CHRNA7), p(HGNCGENEFAMILY:"G protein subunits beta")) - pmid:27373205 + pubmed:21482353 - p(HGNC:MAPT, var("p.S422E")) increases a(HBP:"Tau aggregates") + a(CHEBI:choline) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) - pmid:27373205 + pubmed:21482353 - p(HGNC:MAPT, var("p.S422E")) increases a(HBP:"Tau oligomers") + a(CHEBI:choline) increases act(p(CONSO:"alpha-7-containing nAChR")) - pmid:27373205 + pubmed:19721446 - p(HGNC:MAPT, var("p.S422E")) decreases bp(GO:"anterograde axonal protein transport") + a(CHEBI:choline) increases bp(MESH:Neuroprotection) - pmid:27373205 + pubmed:19721446 - p(HGNC:MAPT, var("p.S422E")) causesNoChange bp(GO:"retrograde axonal protein transport") + a(CHEBI:choline) decreases act(a(MESH:"alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid")) @@ -147074,38 +148804,23 @@

Statements

- - - pmid:27373205 - - composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT, var("p.S422E"))) increases a(HBP:"Tau oligomers") - + - - - pmid:27373205 - - composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT, var("p.S422E"))) increases a(HBP:"Tau dimers") - + - - - pmid:27373205 - - composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT, var("p.S422E"))) decreases bp(GO:"anterograde axonal protein transport") - + - pmid:27373205 + pubmed:26813123 - composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT, var("p.S422E"))) decreases bp(GO:"retrograde axonal protein transport") + p(HGNC:CHRNA1) increases a(MESH:"Receptors, Nicotinic") @@ -147114,142 +148829,142 @@

Statements

+ + - pmid:27373205 + pubmed:19126755 - composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT)) increases a(HBP:"Tau oligomers") + p(HGNC:CHRNA4) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:27373205 + pubmed:11230871 - composite(a(HBP:"Tau aggregates"), p(HGNC:MAPT)) increases a(HBP:"Tau dimers") + p(HGNC:CHRNA4) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:26631930 + pubmed:19126755 - g(HGNC:MIR219A1) increases complex(g(HGNC:MIR219A1), p(HGNC:MAPT)) + p(HGNC:CHRNA4) association p(HGNC:PTGS2) - - - - - pmid:26631930 + pubmed:19293145 - complex(g(HGNC:MIR219A1), p(HGNC:MAPT)) decreases p(HGNC:MAPT) + p(HGNC:CHRNA4) positiveCorrelation a(CHEBI:amyloid-beta) - pmid:26631930 + pubmed:17009926 - p(HGNC:G3BP1) increases complex(GO:"ribonucleoprotein granule") + p(HGNC:CHRNA4) positiveCorrelation a(CHEBI:amyloid-beta) - pmid:27181519 + pubmed:19293145 - p(HGNC:G3BP1) association complex(GO:"cytoplasmic stress granule") + act(p(HGNC:CHRNA4)) decreases act(a(CHEBI:"L-glutamate(2-)")) - pmid:26631930 + pubmed:19293145 - complex(GO:"ribonucleoprotein granule") increases p(HGNC:MAPT) + act(p(HGNC:CHRNA4)) increases act(a(CHEBI:nicotine)) - pmid:27181519 + pubmed:19721446 - complex(GO:"ribonucleoprotein granule") association bp(GO:"RNA processing") + p(HGNC:CHRNA4) increases act(a(CHEBI:nicotine)) + + - pmid:27181519 + pubmed:19293145 - complex(GO:"ribonucleoprotein granule") regulates a(MESH:"RNA, Messenger") + p(HGNC:CHRNA4) association bp(GO:"lipid metabolic process") + + - pmid:26631930 + pubmed:23038257 - p(HGNC:HM13) increases complex(GO:"ribonucleoprotein granule") + p(HGNC:CHRNA4) association p(MESH:"Cytoskeletal Proteins") - pmid:26631930 + pubmed:23038257 - a(PUBCHEM:354398) decreases act(complex(GO:"mitochondrial respiratory chain complex I")) + p(HGNC:CHRNA4) association bp(GO:"intracellular receptor signaling pathway") - pmid:26631930 + pubmed:17009926 - complex(GO:"mitochondrial respiratory chain complex I") decreases p(HGNC:SRSF2) + p(HGNC:CHRNA4) positiveCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) + + - pmid:26631930 + pubmed:26813123 - p(HGNC:SRSF2) increases p(HBP:"4R tau") + p(HGNC:CHRNA4) increases a(MESH:"Receptors, Nicotinic") - - - pmid:29226865 - - act(p(HGNC:SRSF2)) increases p(HBP:"4R tau") - + - - - pmid:26631930 - - p(HGNC:SRSF2) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") - + + + + + + + @@ -147257,9 +148972,9 @@

Statements

- pmid:29226865 + pubmed:11230871 - act(p(HGNC:SRSF2)) positiveCorrelation p(HGNC:SRSF2, pmod(Ac, Lys, 52)) + p(HGNC:CHRNA4) decreases complex(a(CHEBI:cytisine), p(FPLX:CHRN)) @@ -147268,29 +148983,27 @@

Statements

- - - pmid:26631930 - - complex(a(MESH:RNA), p(HGNC:MAPT)) increases a(HBP:"Tau aggregates") - + - - - pmid:26631930 - - complex(a(MESH:RNA), p(HGNC:MAPT)) increases path(HBP:Neurodegeneration) - + + + + + + + + + - pmid:24561250 + pubmed:26813123 - a(MESH:RNA) increases act(complex(GO:"inflammasome complex")) + p(HGNC:CHRNB1) increases a(MESH:"Receptors, Nicotinic") @@ -147299,11 +149012,19 @@

Statements

+ + + + + + + + - pmid:26631930 + pubmed:26813123 - complex(a(GO:microtubule), p(HBP:"4R tau")) increases bp(GO:"microtubule polymerization") + p(HGNC:CHRND) increases a(MESH:"Receptors, Nicotinic") @@ -147314,28 +149035,18 @@

Statements

- pmid:26631930 + pubmed:19126755 - complex(a(GO:microtubule), p(HBP:"3R tau")) increases bp(GO:"microtubule polymerization") + act(p(HGNC:CHRNG)) increases bp(GO:"long-term synaptic potentiation") - - - pmid:26631930 - - p(HGNC:PPM1A) directlyDecreases p(HGNC:MAPT, pmod(Ph)) - + - - - pmid:26631930 - - p(HGNC:MAPT, pmod(Ph, Ser, 214), pmod(Ph, Thr, 231)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) - + @@ -147343,9 +149054,9 @@

Statements

- pmid:25031639 + pubmed:26813123 - complex(p(HGNC:MAPT), p(HGNC:STUB1)) increases deg(p(HGNC:MAPT)) + p(HGNC:CHRNG) increases a(MESH:"Receptors, Nicotinic") @@ -147354,1222 +149065,1320 @@

Statements

- - - pmid:26631930 + pubmed:26813123 - complex(p(HGNC:MAPK8IP1), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) decreases complex(GO:"kinesin complex") + p(HGNC:CHRNE) increases a(MESH:"Receptors, Nicotinic") + + + + - pmid:26631930 + pubmed:26813123 - complex(p(HGNC:MAPK8IP1), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) decreases complex(GO:"kinesin complex") + p(HGNC:CHRNA2) increases a(MESH:"Receptors, Nicotinic") + + + + - pmid:26631930 + pubmed:19721446 - complex(p(HGNC:MAPK8IP1), p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))) decreases bp(GO:"axonal transport") + p(HGNC:CHRNA2) decreases act(a(CHEBI:nicotine)) + + + + + + + + + + - pmid:26631930 + pubmed:26813123 - complex(GO:"kinesin complex") regulates bp(GO:"axonal transport") + p(HGNC:CHRNA3) increases a(MESH:"Receptors, Nicotinic") + + + + + + + + - pmid:19491104 + pubmed:11230871 - act(complex(GO:"kinesin complex")) positiveCorrelation act(p(HGNC:MAPK8IP1)) + p(HGNC:CHRNA3) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:19491104 + pubmed:11230871 - act(complex(GO:"kinesin complex")) positiveCorrelation act(p(HGNC:KLC1)) + p(HGNC:CHRNA3) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:19491104 + pubmed:19721446 - act(complex(GO:"kinesin complex")) positiveCorrelation bp(GO:"vesicle-mediated transport") + p(HGNC:CHRNA3) association path(MESH:Craving) - pmid:26631930 + pubmed:19721446 - p(HGNC:EP300) increases p(HGNC:MAPT, pmod(Ac, Lys)) + p(HGNC:CHRNA3) association path(MESH:Recurrence) + + - pmid:11691934 + pubmed:28901280 - p(HGNC:EP300) increases p(FPLX:"Histone_H4", pmod(Ac)) + p(HGNC:CHRNA3) positiveCorrelation bp(UBERON:0002138) + + + + + + - pmid:26390242 + pubmed:19126755 - act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac)) + p(HGNC:CHRNA5) decreases path(MESH:"Inflammatory Bowel Diseases") + + + + - pmid:20869593 + pubmed:26813123 - act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 163)) + p(HGNC:CHRNA5) increases a(MESH:"Receptors, Nicotinic") + + + + + + - pmid:20869593 + pubmed:19721446 - act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 174)) + p(HGNC:CHRNA5) decreases act(a(CHEBI:nicotine)) + + - pmid:20869593 + pubmed:28901280 - act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 180)) + p(HGNC:CHRNA5) positiveCorrelation bp(UBERON:0002138) + + + + + + + + + + - pmid:20869593 + pubmed:26813123 - act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 254)) + p(HGNC:CHRNA6) increases a(MESH:"Receptors, Nicotinic") + + + + + + + + + + - pmid:20869593 + pubmed:21787755 - act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 274)) + p(HGNC:CHRNA6) association path(MESH:Reward) - pmid:20869593 + pubmed:21787755 - act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 280)) + p(HGNC:CHRNA6) association bp(MESH:"Drug Interactions") - pmid:20869593 + pubmed:21787755 - act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 281)) + p(HGNC:CHRNA6) association tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + - pmid:20869593 + pubmed:19126755 - act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 290)) + p(HGNC:CHRNA7) association a(MESH:Neurons) + + - pmid:20869593 + pubmed:19126755 - act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 298)) + p(HGNC:CHRNA7) association complex(p(HGNC:CHRNA5), p(HGNC:CHRNA7)) + + - pmid:20869593 + pubmed:19126755 - act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 317)) + p(HGNC:CHRNA7) association complex(p(HGNC:CHRNA7), p(HGNC:CHRNB2)) + + - pmid:20869593 + pubmed:19126755 - act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 321)) + p(HGNC:CHRNA7) association complex(p(HGNC:CHRNA7), p(HGNC:CHRNB3)) + + + + + + - pmid:20869593 + pubmed:19126755 - act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 331)) + act(p(HGNC:CHRNA7)) increases bp(GO:"action potential initiation") - pmid:20869593 + pubmed:19126755 - act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 352)) + act(p(HGNC:CHRNA7, loc(GO:"axon terminus"))) regulates bp(GO:"synaptic transmission, glycinergic") - pmid:20869593 + pubmed:19126755 - act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 369)) + act(p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)", loc(GO:intracellular)) - pmid:20869593 + pubmed:19126755 - act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 370)) + act(p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)", loc(GO:intracellular)) - pmid:20869593 + pubmed:19293145 - act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 383)) + act(p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)") - pmid:20869593 + pubmed:29428175 - act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 385)) + p(HGNC:CHRNA7) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(GO:"endoplasmic reticulum"), toLoc(MESH:Cytoplasm)) - pmid:20869593 + pubmed:29428175 - act(p(HGNC:EP300)) increases p(HGNC:MAPT, pmod(Ac, Lys, 395)) + act(p(HGNC:CHRNA7), ma(GO:"calcium-induced calcium release activity")) increases a(CHEBI:"calcium(2+)", loc(MESH:Cytoplasm)) - pmid:26631930 + pubmed:29428175 - p(HGNC:MAPT, pmod(Ac, Lys, 280)) decreases deg(p(HGNC:MAPT, pmod(Ac, Lys, 280))) + act(p(HGNC:CHRNA7)) increases tloc(a(CHEBI:"calcium(2+)", loc(MESH:"Endoplasmic Reticulum")), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:26631930 + pubmed:22040696 - p(HGNC:MAPT, pmod(Ac, Lys, 280)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:CHRNA7) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:Cytoplasm)) - pmid:29276758 + pubmed:19126755 - p(HGNC:MAPT, pmod(Ac, Lys, 280)) positiveCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNC:CHRNA7)) increases bp(GO:"neuronal action potential") - pmid:21427723 + pubmed:19126755 - p(HGNC:MAPT, pmod(Ac, Lys, 280)) positiveCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNC:CHRNA7, loc(GO:"glutamatergic synapse"))) regulates bp(GO:"synaptic transmission, dopaminergic") - pmid:26631930 + pubmed:19126755 - p(HGNC:MAPT, pmod(Ac, Lys, 280)) positiveCorrelation path(MESH:"Niemann-Pick Diseases") + act(p(HGNC:CHRNA7, loc(GO:"glutamatergic synapse"))) increases a(CHEBI:"glutamate(2-)", loc(MESH:"Dopaminergic Neurons")) - pmid:26631930 + pubmed:19126755 - p(HGNC:MAPT, pmod(Ac, Lys, 280)) positiveCorrelation path(MESH:"Frontotemporal Dementia") + p(HGNC:CHRNA7, loc(MESH:"Mossy Fibers, Hippocampal")) regulates a(CHEBI:"glutamate(2-)", loc(MESH:"Pyramidal Cells")) - pmid:26631930 + pubmed:19293145 - p(HGNC:MAPT, pmod(Ac, Lys, 280)) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") + act(p(HGNC:CHRNA7)) decreases act(a(CHEBI:"glutamate(2-)")) - pmid:29276758 + pubmed:17009926 - p(HGNC:MAPT, pmod(Ac, Lys, 280)) decreases a(MESH:Neurons) + act(p(HGNC:CHRNA7)) increases tloc(a(CHEBI:"glutamate(2-)"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:29276758 + pubmed:30697142 - p(HGNC:MAPT, pmod(Ac, Lys, 280)) positiveCorrelation path(MESH:"Chronic Traumatic Encephalopathy") + p(HGNC:CHRNA7) increases a(CHEBI:"glutamate(2-)") - pmid:26940749 + pubmed:19126755 - p(HGNC:MAPT, pmod(Ac, Lys, 280)) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + p(HGNC:CHRNA7) positiveCorrelation bp(GO:cognition) - pmid:26940749 + pubmed:19126755 - p(HGNC:MAPT, pmod(Ac, Lys, 280)) increases path(HBP:Neurodegeneration) + act(p(HGNC:CHRNA7)) association bp(GO:cognition) - pmid:26192747 + pubmed:27190210 - p(HGNC:MAPT, pmod(Ac, Lys, 280)) isA p(HGNC:MAPT, pmod(Ac)) + p(HGNC:CHRNA7) association bp(GO:cognition) - pmid:26192747 + pubmed:27190210 - p(HGNC:MAPT, pmod(Ac, Lys, 280)) partOf p(HBP:"microtubule-binding region") + p(HGNC:CHRNA7) increases bp(GO:cognition) - pmid:21427723 + pubmed:22530628 - p(HGNC:MAPT, pmod(Ac, Lys, 280)) positiveCorrelation path(HBP:"Corticobasal Degeneration") + p(HGNC:CHRNA7) increases bp(GO:cognition) - pmid:26631930 + pubmed:30697142 - p(HGNC:MAPT, pmod(Ac, Lys, 163)) decreases deg(p(HGNC:MAPT, pmod(Ac, Lys, 163))) + p(HGNC:CHRNA7) regulates bp(GO:cognition) - pmid:26192747 + pubmed:19721446 - p(HGNC:MAPT, pmod(Ac, Lys, 163)) isA p(HGNC:MAPT, pmod(Ac)) + p(HGNC:CHRNA7) positiveCorrelation bp(GO:cognition) - pmid:26631930 + pubmed:19721446 - p(HGNC:MAPT, pmod(Ac, Lys, 281)) decreases deg(p(HGNC:MAPT, pmod(Ac, Lys, 281))) + act(p(HGNC:CHRNA7)) increases bp(GO:cognition) - pmid:27041503 + pubmed:19126755 - p(HGNC:MAPT, pmod(Ac, Lys, 281)) decreases bp(GO:memory) + p(HGNC:CHRNA7) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:27041503 + pubmed:19293145 - p(HGNC:MAPT, pmod(Ac, Lys, 281)) decreases bp(GO:"regulation of synaptic plasticity") + p(HGNC:CHRNA7) association path(MESH:"Alzheimer Disease") - pmid:27041503 + pubmed:11230871 - p(HGNC:MAPT, pmod(Ac, Lys, 281)) decreases p(HGNC:WWC1) + p(HGNC:CHRNA7) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:26631930 + pubmed:22040696 - p(HGNC:MAPT, pmod(Ac, Lys, 369)) decreases deg(p(HGNC:MAPT, pmod(Ac, Lys, 369))) + p(HGNC:CHRNA7) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:26192747 + pubmed:29191965 - p(HGNC:MAPT, pmod(Ac, Lys, 369)) isA p(HGNC:MAPT, pmod(Ac)) + p(HGNC:CHRNA7) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:26192747 + pubmed:19126755 - p(HGNC:MAPT, pmod(Ac, Lys, 369)) partOf p(HBP:"microtubule-binding region") + act(p(HGNC:CHRNA7)) increases tloc(a(CHEBI:"gamma-aminobutyric acid"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:26631930 + pubmed:19126755 - p(HGNC:MAPT, pmod(Ac, Lys, 259)) increases deg(p(HGNC:MAPT, pmod(Ac, Lys, 259))) + act(p(HGNC:CHRNA7)) regulates a(CHEBI:dopamine, loc(GO:"extracellular region")) - pmid:26631930 + pubmed:19126755 - p(HGNC:MAPT, pmod(Ac, Lys, 259)) decreases p(HGNC:MAPT, pmod(Ph)) + act(p(HGNC:CHRNA7)) increases a(CHEBI:dopamine, loc(GO:"extracellular region")) - pmid:26631930 + pubmed:19126755 - p(HGNC:MAPT, pmod(Ac, Lys, 259)) decreases a(HBP:"Tau aggregates") + act(p(HGNC:CHRNA7)) association path(MESH:"Sensory Gating") + + - pmid:26192747 + pubmed:19126755 - p(HGNC:MAPT, pmod(Ac, Lys, 259)) isA p(HGNC:MAPT, pmod(Ac)) + act(p(HGNC:CHRNA7)) increases a(CHEBI:amyloid-beta, loc(GO:intracellular)) - pmid:26192747 + pubmed:19293145 - p(HGNC:MAPT, pmod(Ac, Lys, 259)) partOf p(HBP:"microtubule-binding region") + p(HGNC:CHRNA7) positiveCorrelation a(CHEBI:amyloid-beta) - pmid:26631930 + pubmed:19293145 - p(HGNC:MAPT, pmod(Ac, Lys, 290)) increases deg(p(HGNC:MAPT, pmod(Ac, Lys, 290))) + p(HGNC:CHRNA7) decreases act(a(CHEBI:amyloid-beta)) - pmid:26631930 + pubmed:19293145 - p(HGNC:MAPT, pmod(Ac, Lys, 290)) decreases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:CHRNA7) increases a(CHEBI:amyloid-beta) - pmid:26631930 + pubmed:19293145 - p(HGNC:MAPT, pmod(Ac, Lys, 290)) decreases a(HBP:"Tau aggregates") + p(HGNC:CHRNA7) association a(CHEBI:amyloid-beta) - pmid:26631930 + pubmed:17009926 - p(HGNC:MAPT, pmod(Ac, Lys, 321)) increases deg(p(HGNC:MAPT, pmod(Ac, Lys, 321))) + p(HGNC:CHRNA7) positiveCorrelation a(CHEBI:amyloid-beta) - pmid:26631930 + pubmed:26979166 - p(HGNC:MAPT, pmod(Ac, Lys, 321)) decreases p(HGNC:MAPT, pmod(Ph)) + act(p(HGNC:CHRNA7, loc(MESH:Microglia))) increases deg(a(CHEBI:amyloid-beta)) - pmid:26631930 + pubmed:29191965 - p(HGNC:MAPT, pmod(Ac, Lys, 321)) decreases a(HBP:"Tau aggregates") + p(HGNC:CHRNA7) regulates act(a(CHEBI:amyloid-beta)) - pmid:26192747 + pubmed:19126755 - p(HGNC:MAPT, pmod(Ac, Lys, 321)) isA p(HGNC:MAPT, pmod(Ac)) + act(p(HGNC:CHRNA7)) increases a(CHEBI:anandamide) - pmid:26192747 + pubmed:19126755 - p(HGNC:MAPT, pmod(Ac, Lys, 321)) partOf p(HBP:"microtubule-binding region") + p(HGNC:CHRNA7) regulates bp(GO:"cell cycle") - pmid:28760828 + pubmed:19126755 - p(HGNC:MAPT, pmod(Ac, Lys, 321)) decreases p(HBP:"Tau aggregates") + p(HGNC:CHRNA7) regulates bp(MESH:Apoptosis) - pmid:28760828 + pubmed:27190210 - p(HGNC:MAPT, pmod(Ac, Lys, 321)) decreases p(HGNC:MAPT, pmod(Ph, Ser, 324)) + p(HGNC:CHRNA7) association bp(MESH:Apoptosis) - pmid:26631930 + pubmed:26979166 - p(HGNC:MAPT, pmod(Ac, Lys, 353)) increases deg(p(HGNC:MAPT, pmod(Ac, Lys, 353))) + act(p(HGNC:CHRNA7)) decreases bp(MESH:Apoptosis) - pmid:26631930 + pubmed:19126755 - p(HGNC:MAPT, pmod(Ac, Lys, 353)) decreases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:CHRNA7) regulates bp(MESH:"Cell Differentiation") - pmid:26631930 + pubmed:19126755 - p(HGNC:MAPT, pmod(Ac, Lys, 353)) decreases a(HBP:"Tau aggregates") + act(p(HGNC:CHRNA7)) association a(CHEBI:nicotine) - pmid:26631930 + pubmed:19126755 - p(HGNC:MAPT, pmod(Ac, Lys, 174)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:CHRNA7) regulates a(CHEBI:nicotine) - pmid:26390242 + pubmed:19293145 - p(HGNC:MAPT, pmod(Ac, Lys, 174)) decreases deg(p(HGNC:MAPT)) + p(HGNC:CHRNA7) regulates act(a(CHEBI:nicotine)) - pmid:26390242 + pubmed:19126755 - p(HGNC:MAPT, pmod(Ac, Lys, 174)) decreases bp(GO:cognition) + p(HGNC:CHRNA7) regulates path(MESH:"Substance Withdrawal Syndrome") - pmid:26390242 + pubmed:19293145 - p(HGNC:MAPT, pmod(Ac, Lys, 174)) increases path(HBP:Neurodegeneration) + p(HGNC:CHRNA7) association path(MESH:"Plaque, Amyloid") - pmid:26631930 + pubmed:19293145 - p(HGNC:MAPT, pmod(NGlyco)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:CHRNA7) increases act(a(CHEBI:galanthamine)) - pmid:26631930 + pubmed:19293145 - p(HGNC:MAPT, pmod(NGlyco)) regulates a(HBP:"paired helical filaments") + act(p(HGNC:CHRNA7)) decreases act(a(CHEBI:ethanol)) - pmid:26631930 + pubmed:19293145 - p(HGNC:MAPT, pmod(NGlyco)) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + act(p(HGNC:CHRNA7)) decreases bp(GO:"cell death") - pmid:26631930 + pubmed:19293145 - p(HGNC:MAPT, pmod(NGlyco)) increases p(HGNC:MAPT, pmod(Ph)) + act(p(HGNC:CHRNA7)) increases a(CHEBI:glucose) - pmid:26631930 + pubmed:19293145 - p(HGNC:MAPT, pmod(OGlyco)) decreases p(HGNC:MAPT, pmod(Ph)) + act(p(HGNC:CHRNA7)) increases a(MESH:Oxygen) - pmid:26631930 + pubmed:19293145 - p(HGNC:MAPT, pmod(OGlyco)) decreases a(HBP:"Tau aggregates") + act(p(HGNC:CHRNA7)) decreases act(a(CHEBI:"L-glutamate(2-)")) - pmid:26631930 + pubmed:19293145 - p(HGNC:MAPT, pmod(OGlyco)) decreases a(HBP:"Tau aggregates") + act(p(HGNC:CHRNA7)) causesNoChange act(a(CHEBI:N-methyl-4-phenylpyridinium)) - pmid:26631930 + pubmed:19293145 - p(HGNC:MAPT, pmod(OGlyco)) decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + act(p(HGNC:CHRNA7)) decreases act(p(HGNC:FAS)) + + + + - pmid:26631930 + pubmed:19293145 - p(HGNC:MAPT, pmod(HBP:glycation)) increases a(HBP:"Tau aggregates") + p(HGNC:CHRNA7) decreases path(CONSO:neurotoxicity) - pmid:26631930 + pubmed:19293145 - p(HGNC:MAPT, pmod(HBP:glycation)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + act(p(HGNC:CHRNA7)) increases act(p(HGNC:JAK2)) - pmid:19517062 + pubmed:26979166 - p(HGNC:MAPT, pmod(HBP:glycation)) increases a(CHEBI:"advanced glycation end-product") + act(p(HGNC:CHRNA7)) directlyIncreases act(p(HGNC:JAK2)) - pmid:19517062 + pubmed:19293145 - p(HGNC:MAPT, pmod(HBP:glycation)) partOf p(HBP:"Tau aggregates") + p(HGNC:CHRNA7) increases bp(GO:"MAPK cascade") - pmid:19517062 + pubmed:19293145 - p(HGNC:MAPT, pmod(HBP:glycation)) increases a(HBP:"Tau oligomers") + p(HGNC:CHRNA7) increases bp(GO:"MAPK cascade") + + + + - pmid:19517062 + pubmed:19293145 - p(HGNC:MAPT, pmod(HBP:glycation)) increases complex(a(CHEBI:"advanced glycation end-product"), p(HGNC:MAPT, pmod(HBP:glycation))) + act(p(HGNC:CHRNA7)) increases bp(GO:"calcium ion transport") - pmid:26631930 + pubmed:27190210 - p(HGNC:MAPT, pmod(HBP:deamidation)) increases a(HBP:"Tau aggregates") + p(HGNC:CHRNA7) increases bp(GO:"calcium ion transport") - pmid:26631930 + pubmed:27190210 - p(HGNC:MAPT, pmod(GO:"protein peptidyl-prolyl isomerization")) increases a(HBP:"Tau aggregates") + p(HGNC:CHRNA7) increases bp(GO:"calcium ion transport") - pmid:26631930 + pubmed:30697142 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) positiveCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNC:CHRNA7)) increases bp(GO:"calcium ion transport") - pmid:26631930 + pubmed:19293145 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) positiveCorrelation path(MESH:Tauopathies) + act(p(HGNC:CHRNA7)) association bp(GO:"calcium-mediated signaling") - pmid:26631930 + pubmed:29428175 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + act(p(HGNC:CHRNA7)) increases bp(GO:"calcium-mediated signaling") + + - pmid:16566606 + pubmed:19293145 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) decreases bp(GO:"tubulin complex assembly") + p(HGNC:CHRNA7) increases act(p(HGNCGENEFAMILY:"Ryanodine receptors")) + + + + - pmid:16566606 + pubmed:19293145 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) association p(HGNC:MAPT, pmod(HBP:misfolded)) + act(p(HGNC:CHRNA7)) increases tloc(p(CONSO:sAPP-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + - pmid:22057784 + pubmed:18986241 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) positiveCorrelation path(MESH:"Pick Disease of the Brain") + p(HGNC:CHRNA7) increases complex(a(CHEBI:amyloid-beta), p(HGNC:CHRNA7)) + + + + + + + + + + + + - pmid:18562203 + pubmed:27190210 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) association act(a(MESH:Astrocytes)) + p(HGNC:CHRNA7) association bp(GO:"learning or memory") - pmid:18562203 + pubmed:27190210 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) positiveCorrelation path(MESH:"Plaque, Amyloid") + act(p(HGNC:CHRNA7)) increases bp(GO:"learning or memory") - pmid:17050703 + pubmed:22530628 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) isA p(HGNC:MAPT, pmod(HBP:nitration)) + p(HGNC:CHRNA7) increases bp(GO:"learning or memory") - pmid:16566606 + pubmed:22530628 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) decreases bp(GO:"microtubule polymerization") + p(HGNC:CHRNA7) increases bp(GO:"learning or memory") - pmid:16566606 + pubmed:27190210 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) positiveCorrelation a(HBP:"paired helical filaments") + p(HGNC:CHRNA7) association bp(MESH:Immunity) - pmid:16566606 + pubmed:27190210 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18)) negativeCorrelation act(p(HGNC:MAPT)) + p(HGNC:CHRNA7) association path(MESH:Inflammation) - pmid:26631930 + pubmed:27190210 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:CHRNA7) increases path(MESH:Inflammation) - pmid:17050703 + pubmed:27190210 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:CHRNA7) regulates path(MESH:Inflammation) - pmid:26631930 + pubmed:26979166 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) positiveCorrelation path(MESH:Tauopathies) + act(p(HGNC:CHRNA7)) decreases path(MESH:Inflammation) - pmid:26631930 + pubmed:26979166 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + p(HGNC:CHRNA7) decreases path(MESH:Inflammation) - pmid:16566606 + pubmed:26979166 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) decreases bp(GO:"tubulin complex assembly") + p(HGNC:CHRNA7) decreases path(MESH:Inflammation) - pmid:16566606 + pubmed:26979166 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) association p(HGNC:MAPT, pmod(HBP:misfolded)) + act(p(HGNC:CHRNA7, loc(MESH:Microglia))) decreases path(MESH:Inflammation) - pmid:22057784 + pubmed:26979166 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) positiveCorrelation path(MESH:"Pick Disease of the Brain") + act(p(HGNC:CHRNA7, loc(MESH:Macrophages))) decreases path(MESH:Inflammation) - pmid:17050703 + pubmed:26979166 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) association a(HBP:"paired helical filaments") + act(p(HGNC:CHRNA7)) decreases path(MESH:Inflammation) - pmid:16566606 + pubmed:26979166 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) positiveCorrelation a(HBP:"paired helical filaments") + act(p(HGNC:CHRNA7)) decreases path(MESH:Inflammation) - pmid:17050703 + pubmed:30697142 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) positiveCorrelation bp(GO:"neurofibrillary tangle assembly") + p(HGNC:CHRNA7) decreases path(MESH:Inflammation) - pmid:17050703 + pubmed:28901280 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) partOf a(GO:"neurofibrillary tangle") + p(HGNC:CHRNA7) regulates path(MESH:Inflammation) - pmid:17050703 + pubmed:27190210 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) partOf path(MESH:"Plaque, Amyloid") + p(HGNC:CHRNA7) association bp(MESH:Neuroprotection) - pmid:17050703 + pubmed:27190210 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) partOf a(MESH:"Neuropil Threads") + act(p(HGNC:CHRNA7)) increases bp(MESH:Neuroprotection) - pmid:17050703 + pubmed:26979166 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) association path(HBP:"Corticobasal Degeneration") + p(HGNC:CHRNA7) increases bp(MESH:Neuroprotection) - pmid:17050703 + pubmed:19721446 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) association path(MESH:"Supranuclear Palsy, Progressive") + p(HGNC:CHRNA7) association bp(MESH:Neuroprotection) - pmid:17050703 + pubmed:19721446 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) isA p(HGNC:MAPT, pmod(HBP:nitration)) + act(p(HGNC:CHRNA7)) decreases bp(MESH:Neuroprotection) - pmid:16566606 + pubmed:27190210 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) decreases bp(GO:"microtubule polymerization") + p(HGNC:CHRNA7) increases tloc(a(CHEBI:neurotransmitter), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:16566606 + pubmed:27190210 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) negativeCorrelation act(p(HGNC:MAPT)) + p(HGNC:CHRNA7) increases path(MESH:"Mental Processes") - pmid:26631930 + pubmed:27190210 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) positiveCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNC:CHRNA7)) increases path(MESH:Attention) - pmid:26631930 + pubmed:22530628 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) positiveCorrelation path(MESH:Tauopathies) + p(HGNC:CHRNA7) increases path(MESH:Attention) - pmid:26631930 + pubmed:22530628 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + p(HGNC:CHRNA7) increases path(MESH:Attention) - pmid:16566606 + pubmed:27190210 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) decreases bp(GO:"tubulin complex assembly") + p(HGNC:CHRNA7) increases path(MESH:Reward) - pmid:16566606 + pubmed:27190210 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) association p(HGNC:MAPT, pmod(HBP:misfolded)) + p(HGNC:CHRNA7) association bp(GO:"cell differentiation") - pmid:16566606 + pubmed:27190210 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) decreases bp(GO:"microtubule polymerization") + p(HGNC:CHRNA7) association bp(GO:"cell migration") - pmid:16566606 + pubmed:27190210 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 394)) positiveCorrelation a(HBP:"paired helical filaments") + p(HGNC:CHRNA7) association bp(GO:"cell adhesion") - pmid:26631930 + pubmed:27190210 - p(HGNC:MAPT, pmod(Me, Lys)) decreases a(HBP:"Tau aggregates") + p(HGNC:CHRNA7) association bp(GO:angiogenesis) - pmid:24869773 + pubmed:27190210 - p(HGNC:MAPT, pmod(Me, Lys)) decreases a(HBP:"Tau aggregates") + p(HGNC:CHRNA7) regulates bp(GO:"receptor signaling pathway via JAK-STAT") - pmid:26631930 + pubmed:27190210 - p(HGNC:MAPT, pmod(Me)) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:CHRNA7) regulates bp(GO:"regulation of phosphatidylinositol 3-kinase signaling") - pmid:26631930 + pubmed:27190210 - p(HGNC:MAPT, frag("26_230")) positiveCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:CHRNA7) regulates bp(GO:"microglial cell activation") - pmid:26631930 + pubmed:26979166 - p(HGNC:MAPT, frag("124_441")) directlyIncreases complex(a(GO:microtubule), p(HGNC:MAPT, frag("124_441"))) + act(p(HGNC:CHRNA7)) decreases bp(GO:"microglial cell activation") - - - - - - - - - - - - - pmid:26631930 + pubmed:26979166 - complex(p(HGNC:DCTN1), p(HGNC:MAPT)) increases complex(a(GO:microtubule), p(HGNC:DCTN1)) + act(p(HGNC:CHRNA7)) decreases bp(GO:"microglial cell activation") - pmid:8391280 + pubmed:26979166 - complex(p(HGNC:DCTN1), p(HGNC:MAPT)) isA p(INTERPRO:"Dynein associated protein") + p(HGNC:CHRNA7) decreases bp(GO:"microglial cell activation") - pmid:8391280 + pubmed:26979166 - complex(p(HGNC:DCTN1), p(HGNC:MAPT)) negativeCorrelation g(DBSNP:rs63750424) + act(p(HGNC:CHRNA7, loc(MESH:Microglia))) increases bp(GO:"microglial cell activation") @@ -148578,25 +150387,13 @@

Statements

- - - pmid:26631930 - - complex(a(GO:microtubule), p(HGNC:DCTN1)) increases complex(a(GO:microtubule), a(MESH:Dyneins)) - - - - - pmid:26631930 - - complex(p(HGNC:APP), p(HGNC:SLC40A1)) increases sec(a(CHEBI:"iron(0)")) - + @@ -148606,559 +150403,532 @@

Statements

- pmid:26631930 + pubmed:17009926 - complex(a(MESH:Actins), p(HGNC:MAPT)) increases a(GO:"actin filament bundle") + p(HGNC:CHRNA7) increases bp(GO:"neurotransmitter secretion") - pmid:26631930 + pubmed:29428175 - complex(a(MESH:Actins), p(HGNC:MAPT)) regulates a(GO:"actin cytoskeleton") + p(HGNC:CHRNA7) regulates bp(GO:"neurotransmitter secretion") - pmid:26631930 + pubmed:22040696 - p(HGNC:MAPT, var("p.Asn279Lys")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + p(HGNC:CHRNA7) increases bp(GO:"neurotransmitter secretion") - pmid:26631930 + pubmed:17009926 - p(HGNC:MAPT, var("p.Asn279Lys")) increases a(HBP:"Tau aggregates") + p(HGNC:CHRNA7) increases act(complex(GO:"voltage-gated calcium channel complex")) - pmid:26631930 + pubmed:17009926 - p(HGNC:MAPT, var("p.Arg5His")) decreases complex(p(HGNC:DCTN1), p(HGNC:MAPT)) + act(p(HGNC:CHRNA7)) increases bp(GO:"synaptic transmission, glutamatergic") - pmid:26631930 + pubmed:17009926 - p(HGNC:MAPT, var("p.Arg5His")) decreases bp(GO:"axonal transport") + p(HGNC:CHRNA7) association a(CONSO:"amyloid-beta aggregates") - pmid:26631930 + pubmed:17009926 - p(HGNC:MAPT, var("p.Arg5His")) decreases act(p(HGNC:MAPT)) + p(HGNC:CHRNA7) positiveCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:26631930 + pubmed:22530628 - p(HGNC:MAPT, var("p.Arg5Leu")) decreases complex(p(HGNC:DCTN1), p(HGNC:MAPT)) + p(HGNC:CHRNA7) association path(DOID:"Alzheimer's disease") - pmid:26631930 + pubmed:22530628 - p(HGNC:MAPT, var("p.Arg5Leu")) decreases bp(GO:"axonal transport") + p(HGNC:CHRNA7) association path(DOID:schizophrenia) - pmid:26631930 + pubmed:22530628 - p(HGNC:MAPT, var("p.Leu266Val")) decreases p(HBP:"4R tau") + p(HGNC:CHRNA7) association path(DOID:"Parkinson's disease") - pmid:26631930 + pubmed:22530628 - p(HGNC:MAPT, var("p.Leu266Val")) increases p(HBP:"3R tau") + p(HGNC:CHRNA7) association path(MESH:"Tobacco Use Disorder") - pmid:26631930 + pubmed:22530628 - p(HBP:"VQIINK motif") increases a(HBP:"Tau aggregates") + p(HGNC:CHRNA7) increases act(p(HGNC:AKT1)) - pmid:26631930 + pubmed:22530628 - p(HBP:"VQIINK motif") increases a(HBP:"Tau aggregates") + act(p(HGNC:CHRNA7)) increases act(p(HGNC:AKT1)) - pmid:17493042 + pubmed:22530628 - p(HBP:"VQIINK motif") partOf p(HBP:"tubulin-binding repeat 2") + p(HGNC:CHRNA7) increases p(HGNC:AKT1) - pmid:17493042 + pubmed:29428175 - p(HBP:"VQIINK motif") increases bp(GO:"neurofibrillary tangle assembly") + p(HGNC:CHRNA7) increases act(p(HGNC:AKT1), ma(GO:"GTPase activity")) - pmid:28002468 + pubmed:22530628 - p(HBP:"VQIINK motif") equivalentTo p(HGNC:MAP4, frag("992_999")) + p(HGNC:CHRNA7) increases act(p(HGNC:GSK3B)) - pmid:28002468 + pubmed:22530628 - p(HBP:"VQIINK motif") equivalentTo p(HGNC:MAP4, frag("1023_1030")) + p(HGNC:CHRNA7) increases bp(MESH:"Sensory Gating") - pmid:11606569 + pubmed:19721446 - p(HBP:"VQIINK motif") positiveCorrelation p(HGNC:MAPT, var("p.Lys280del")) + p(HGNC:CHRNA7) association bp(MESH:"Sensory Gating") - pmid:11606569 + pubmed:22530628 - p(HBP:"VQIINK motif") positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) + p(HGNC:CHRNA7) increases bp(MESH:"Cell Survival") - pmid:11606569 + pubmed:28901280 - p(HBP:"VQIINK motif") increases p(HBP:"Tau aggregates") + p(HGNC:CHRNA7) regulates bp(MESH:"Cell Survival") - pmid:26631930 + pubmed:22530628 - a(CHEBI:"polyanionic polymer") increases a(HBP:"Tau aggregates") + p(HGNC:CHRNA7) increases p(HGNC:PIK3CA) - pmid:26631930 + pubmed:22530628 - a(CHEBI:"polyanionic polymer") increases a(HBP:"Tau aggregates") + p(HGNC:CHRNA7) increases p(HGNC:MAPK3) - pmid:26631930 + pubmed:22530628 - p(HGNC:YWHAZ) increases a(HBP:"Tau aggregates") + p(HGNC:CHRNA7) increases p(HGNC:MAPK1) - pmid:12551948 + pubmed:22530628 - p(HGNC:YWHAZ) isA complex(p(HGNC:GSK3B), p(HGNC:MAPT), p(HGNC:YWHAZ)) + p(HGNC:CHRNA7) increases p(HGNC:CREBBP) - pmid:12551948 + pubmed:22530628 - p(HGNC:YWHAZ) association p(HGNC:MAPT) + p(HGNC:CHRNA7) increases act(p(HGNC:PIK3R1)) - pmid:12551948 + pubmed:22530628 - p(HGNC:YWHAZ) association p(HGNC:GSK3B) + p(HGNC:CHRNA7) positiveCorrelation r(HGNC:ARC) - pmid:12551948 + pubmed:22530628 - p(HGNC:YWHAZ) increases act(p(HGNC:GSK3B)) + p(HGNC:CHRNA7) increases p(HGNC:ARC) - pmid:22941973 + pubmed:26813123 - act(p(HGNC:YWHAZ)) increases p(RGD:Mapt, pmod(Ph, Ser, 262)) + p(HGNC:CHRNA7) increases a(MESH:"Receptors, Nicotinic") - pmid:22941973 + pubmed:29428175 - act(p(HGNC:YWHAZ)) decreases complex(a(MESH:Microtubules), p(RGD:Mapt)) + act(p(HGNC:CHRNA7), ma(GO:"calcium-induced calcium release activity")) increases tloc(a(CHEBI:"calcium ion"), fromLoc(GO:"endoplasmic reticulum"), toLoc(MESH:Cytoplasm)) - pmid:22941973 + pubmed:29428175 - act(p(HGNC:YWHAZ)) decreases bp(GO:"microtubule polymerization") + act(p(HGNC:CHRNA7), ma(GO:"calcium-induced calcium release activity")) increases tloc(a(CHEBI:"calcium ion"), fromLoc(GO:"endoplasmic reticulum"), toLoc(MESH:Cytoplasm)) - pmid:22941973 + pubmed:29428175 - act(p(HGNC:YWHAZ)) increases deg(p(RGD:Syp)) + act(p(HGNC:CHRNA7), ma(GO:"calcium-induced calcium release activity")) regulates a(CHEBI:"calcium ion", loc(MESH:"Intracellular Space")) - pmid:22941973 + pubmed:26979166 - act(p(HGNC:YWHAZ)) increases act(p(FPLX:Proteasome)) + p(HGNC:CHRNA7) regulates a(CHEBI:"calcium ion", loc(MESH:"Intracellular Space")) - pmid:26631930 + pubmed:26979166 - p(HGNC:MAPT, frag("151_391")) increases a(HBP:"Tau aggregates") + act(p(HGNC:CHRNA7)) increases tloc(a(CHEBI:"calcium ion"), fromLoc(GO:"pore complex"), toLoc(MESH:"Intracellular Space")) - - - pmid:26631930 - - p(HGNC:MAPT, frag("1_368")) increases a(HBP:"Tau aggregates") - - - pmid:26631930 + pubmed:29428175 - p(HGNC:MAPT, frag("1_368")) increases path(HBP:Neurodegeneration) + act(p(HGNC:CHRNA7)) positiveCorrelation bp(GO:"glutamate secretion") - pmid:26631930 + pubmed:29428175 - p(HGNC:MAPT, frag("1_368")) decreases bp(GO:"microtubule polymerization") + p(HGNC:CHRNA7) increases bp(MESH:"Calcium Signaling") - pmid:26631930 + pubmed:29428175 - p(HGNC:F2) increases p(HGNC:MAPT, frag("258_360")) + p(HGNC:CHRNA7) increases bp(MESH:"Calcium Signaling") - pmid:26631930 + pubmed:29428175 - p(HGNC:MAPT, frag("258_360")) increases a(HBP:"Tau aggregates") + p(HGNC:CHRNA7) regulates bp(MESH:"Calcium Signaling") - pmid:26631930 + pubmed:29428175 - p(HGNC:CTSL) increases p(HGNC:MAPT, frag("258_360")) + act(p(HGNC:CHRNA7), ma(GO:"calcium-induced calcium release activity")) increases bp(MESH:"Calcium Signaling") - pmid:26631930 + pubmed:29428175 - tloc(p(HGNC:TTLL6), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) increases act(a(CHEBI:"amyloid-beta")) + p(HGNC:CHRNA7) increases bp(MESH:"Calcium Signaling") - pmid:26631930 + pubmed:29428175 - p(HGNC:SPAST) increases bp(GO:"microtubule severing") + act(p(HGNC:CHRNA7)) regulates p(MESH:"Receptors, Glutamate", loc(GO:"postsynaptic membrane")) - - - - - pmid:26631930 + pubmed:29428175 - complex(p(HGNC:DLG4), p(HGNC:FYN)) increases act(a(GO:"glutamatergic synapse")) + act(p(HGNC:CHRNA7)) increases bp(GO:"sodium ion import across plasma membrane") - pmid:26631930 + pubmed:26979166 - complex(p(HGNC:DLG4), p(HGNC:FYN)) increases act(a(CHEBI:"amyloid-beta")) + act(p(HGNC:CHRNA7)) increases bp(GO:"sodium ion import across plasma membrane") - pmid:26631930 + pubmed:29428175 - p(HGNC:GRIN2B, pmod(Ph)) increases complex(p(HGNC:DLG4), p(HGNC:FYN)) + act(p(HGNC:CHRNA7)) increases bp(GO:"calcium ion import across plasma membrane") - - - - - - - pmid:22817713 + pubmed:29428175 - complex(a(HBP:"Tau oligomers"), p(HGNC:HSPA1A)) decreases bp(GO:"anterograde axonal protein transport") + act(p(HGNC:CHRNA7)) increases bp(GO:"calcium ion import across plasma membrane") - pmid:22817713 + pubmed:29428175 - complex(a(HBP:"Tau oligomers"), p(HGNC:HSPA1A)) increases bp(GO:"anterograde axonal protein transport") + act(p(HGNC:CHRNA7)) increases bp(GO:"calcium ion import across plasma membrane") - pmid:22817713 + pubmed:29428175 - bp(GO:"regulation of microtubule cytoskeleton organization") association p(HGNC:MAPT) + act(p(HGNC:CHRNA7)) increases bp(GO:"membrane depolarization") - pmid:22817713 + pubmed:30697142 - a(CHEBI:"arachidonic acid") increases a(HBP:"Tau oligomers") + p(HGNC:CHRNA7) increases bp(GO:"membrane depolarization") - - - pmid:22817713 - - a(CHEBI:"arachidonic acid") increases a(HBP:"Tau aggregates") - + - pmid:22817713 + pubmed:29428175 - p(HGNC:PPP1CA) decreases bp(GO:"anterograde axonal protein transport") + p(HGNC:CHRNA7) regulates bp(GO:"neuron projection development") - pmid:29334120 + pubmed:29428175 - p(HGNC:PPP1CA) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 397)) + act(p(HGNC:CHRNA7), ma(GO:"calcium-induced calcium release activity")) regulates bp(GO:"hippocampus development") - pmid:29334120 + pubmed:29428175 - p(HGNC:PPP1CA) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 403)) + act(p(HGNC:CHRNA7), ma(GO:"calcium-induced calcium release activity")) regulates bp(GO:"neuron maturation") - pmid:29334120 + pubmed:29428175 - p(HGNC:PPP1CA) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 404)) + act(p(HGNC:CHRNA7)) increases bp(GO:"regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity") - pmid:29334120 + pubmed:29428175 - p(HGNC:PPP1CA) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 409)) + p(HGNC:CHRNA7) increases bp(GO:"regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity") - pmid:29334120 + pubmed:29428175 - p(HGNC:PPP1CA) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 410)) + p(HGNC:CHRNA7, loc(MESH:Synapses)) increases bp(GO:"positive regulation of cAMP-dependent protein kinase activity") - pmid:26142647 + pubmed:29428175 - act(p(HGNC:PPP1CA)) directlyDecreases p(HGNC:EIF2S1, pmod(Ph)) + p(HGNC:CHRNA7, loc(MESH:Synapses)) increases p(HGNC:CAMK2B) - pmid:25001178 + pubmed:29428175 - p(HGNC:PPP1CA) directlyDecreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + act(p(HGNC:CHRNA7), ma(GO:"calcium-induced calcium release activity")) increases act(p(HGNC:CAMK2B, loc(MESH:Synapses))) - pmid:25001178 + pubmed:29428175 - p(HGNC:PPP1CA) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:CHRNA7) increases act(p(HGNC:ADCY1)) - pmid:22817713 + pubmed:26979166 - p(HGNC:MAPT, frag("2_18")) decreases bp(GO:"anterograde axonal protein transport") + act(p(HGNC:CHRNA7)) directlyIncreases act(p(HGNC:ADCY1)) - - - pmid:26671985 - - p(HGNC:MAPT, frag("2_18")) equivalentTo p(HBP:"phosphatase-activating domain") - + - pmid:26671985 + pubmed:29428175 - p(HGNC:MAPT, frag("2_18")) partOf p(HGNC:MAPT, frag("1_151")) + p(HGNC:CHRNA7) regulates bp(GO:"regulation of voltage-gated calcium channel activity") @@ -149167,357 +150937,294 @@

Statements

- - - pmid:22817713 - - composite(p(HGNC:HSPA1A), p(HGNC:MAPT, frag("2_18"))) decreases bp(GO:"anterograde axonal protein transport") - - - - - pmid:29626319 - - p(FPLX:UBE2) increases deg(a(MESH:Proteins)) - - - - - pmid:29626319 - - a(MESH:"Ubiquitin-Protein Ligases") increases deg(a(MESH:Proteins)) - - - pmid:29626319 + pubmed:29428175 - p(HGNC:PSMD7) increases deg(a(MESH:Proteins)) + p(HGNC:CHRNA7, loc(MESH:"Growth Cones")) increases bp(MESH:Growth) - pmid:29626319 + pubmed:29428175 - a(HBP:"20 S Proteasome") increases bp(GO:"proteasomal ubiquitin-independent protein catabolic process") + p(HGNC:CHRNA7, loc(MESH:"Growth Cones")) increases a(GO:cytoskeleton) - - - pmid:29626319 - - a(MESH:"Tight Junctions") decreases tloc(a(MESH:Proteins), fromLoc(MESH:Brain), toLoc(MESH:Blood)) - - - pmid:29626319 + pubmed:29428175 - a(HP:"glymphatic system") decreases a(CHEBI:"amyloid-beta") + p(HGNC:CHRNA7) increases act(p(HGNC:CDC42), ma(GO:"GTPase activity")) - pmid:29626319 + pubmed:29428175 - a(HP:"glymphatic system") decreases p(HGNC:MAPT) + p(HGNC:CHRNA7) regulates bp(MESH:"Cell Movement") - pmid:29626319 + pubmed:26979166 - p(HGNC:UBB, var("?")) decreases act(p(HGNC:PSMD7)) + act(p(HGNC:CHRNA7)) increases bp(GO:"calcium ion import") - pmid:29626319 + pubmed:26979166 - p(HGNC:UBB, var("?")) decreases deg(a(CHEBI:"amyloid-beta")) + act(p(HGNC:CHRNA7)) decreases act(p(HGNC:TLR3)) - pmid:29626319 + pubmed:26979166 - a(HBP:"APOE e4") decreases deg(a(CHEBI:"amyloid-beta")) + act(p(HGNC:CHRNA7)) decreases act(p(HGNC:TLR4)) - pmid:29626319 + pubmed:26979166 - a(HBP:"APOE e4") decreases deg(a(CHEBI:"amyloid-beta")) + act(p(HGNC:CHRNA7)) decreases act(p(HGNC:TLR9)) - pmid:29626319 + pubmed:26979166 - p(FPLX:MMP) increases deg(a(CHEBI:"amyloid-beta")) + act(p(HGNC:CHRNA7)) decreases act(p(HGNC:MAPK14)) - pmid:29626319 + pubmed:26979166 - p(HGNC:SERPINF2) increases deg(a(CHEBI:"amyloid-beta")) + act(p(HGNC:CHRNA7)) increases tloc(p(HGNC:TNF), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:29626319 + pubmed:26979166 - p(HGNC:SERPINF2) increases deg(a(CHEBI:"amyloid-beta")) + act(p(HGNC:CHRNA7)) increases tloc(p(HGNC:HMGB1), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:29626319 + pubmed:26979166 - p(HGNC:SERPINF2) negativeCorrelation path(MESH:"Alzheimer Disease") + act(p(HGNC:CHRNA7)) decreases a(MESH:"Immune System") - - - pmid:29626319 - - act(p(HGNC:SERPINF2)) negativeCorrelation path(MESH:"Alzheimer Disease") - - - - - pmid:29626319 - - a(MESH:"Receptors, Scavenger") increases deg(a(CHEBI:"amyloid-beta")) - + - - - pmid:29626319 - - p(HGNC:CMKLR1) increases deg(a(CHEBI:"amyloid-beta")) - + - - - pmid:29626319 - - p(FPLX:TLR) increases deg(a(CHEBI:"amyloid-beta")) - + - pmid:23702978 + pubmed:26979166 - act(p(FPLX:TLR)) increases p(HGNC:NLRP3) + act(p(HGNC:CHRNA7)) regulates act(a(MESH:Microglia)) - pmid:23702978 + pubmed:26979166 - act(p(FPLX:TLR)) increases p(HGNC:IL1B) + act(p(HGNC:CHRNA7)) decreases act(a(MESH:Macrophages)) - pmid:29626319 + pubmed:26979166 - p(HGNC:FPR2) increases deg(a(CHEBI:"amyloid-beta")) + act(p(HGNC:CHRNA7)) decreases tloc(a(MESH:Cytokines), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:29626319 + pubmed:26979166 - p(HGNC:ABCA7) association bp(GO:phagocytosis) + act(p(HGNC:CHRNA7)) increases composite(a(CHEBI:"calcium(2+)"), p(HGNC:ADCY1)) - pmid:29626319 + pubmed:26979166 - p(HGNC:ABCA7) regulates bp(GO:phagocytosis) + act(p(HGNC:CHRNA7)) decreases deg(a(MESH:"Gray Matter")) - pmid:29626319 + pubmed:26979166 - p(HGNC:ABCA7) decreases a(CHEBI:"amyloid-beta") + act(p(HGNC:CHRNA7)) decreases deg(a(MESH:"White Matter")) - pmid:29626319 + pubmed:26979166 - p(HGNC:ABCA7) decreases a(CHEBI:"amyloid-beta") + p(HGNC:CHRNA7) decreases path(MESH:Depression) - pmid:29626319 + pubmed:26979166 - p(HGNC:ABCA7) decreases p(HGNC:BACE1) + p(HGNC:CHRNA7) decreases path(NCIT:C78349) - pmid:29626319 + pubmed:26979166 - p(HGNC:CD33) association bp(GO:phagocytosis) + act(p(HGNC:CHRNA7)) decreases bp(GO:"lymphocyte proliferation") - pmid:29626319 + pubmed:26979166 - p(HGNC:CD33) decreases deg(a(CHEBI:"amyloid-beta")) + act(p(HGNC:CHRNA7)) decreases bp(GO:"macrophage activation") - pmid:29626319 + pubmed:26979166 - p(HGNC:TREM2, var("p.Arg47His")) decreases act(a(MESH:Microglia)) + p(HGNC:CHRNA7) decreases path(CONSO:neuroinflammation) - pmid:29626319 + pubmed:26979166 - p(HGNC:TREM2, var("p.Arg47His")) increases a(CHEBI:"amyloid-beta") + p(HGNC:CHRNA7) decreases deg(a(MESH:"Dopaminergic Neurons")) - pmid:29626319 + pubmed:26979166 - p(HGNC:SLC2A1) increases p(HGNC:LRP1) + act(p(HGNC:CHRNA7, loc(MESH:Microglia))) increases bp(GO:phagocytosis) - - - pmid:29626319 - - p(HGNC:SLC2A1) regulates deg(a(CHEBI:"amyloid-beta")) - + - pmid:29626319 + pubmed:26088141 - p(HGNC:SLC2A1) regulates tloc(a(CHEBI:"amyloid-beta"), fromLoc(MESH:Brain), toLoc(MESH:Blood)) + p(HGNC:CHRNA7) increases complex(p(HGNC:CHRNA7), p(HGNC:GNAQ)) - - - pmid:29626319 - - p(HGNC:SLC2A1) regulates tloc(a(CHEBI:glucose), fromLoc(GO:"extracellular region"), toLoc(MESH:"Blood-Brain Barrier")) - + - - - pmid:29626319 - - p(HGNC:SLC2A1) regulates a(MESH:"Blood-Brain Barrier") - + - pmid:29626319 + pubmed:26088141 - a(HP:"blood-cerebrospinal fluid barrier") decreases a(CHEBI:"amyloid-beta") + p(HGNC:CHRNA7) increases bp(CONSO:"nAChR assembly") + + - pmid:29626319 + pubmed:26088141 - a(MESH:"Choroid Plexus") increases a(MESH:"Cerebrospinal Fluid") + p(HGNC:CHRNA7) increases p(HGNC:CHRNA7) @@ -149526,21 +151233,16 @@

Statements

- pmid:29626319 + pubmed:26088141 - complex(a(CHEBI:"amyloid-beta"), p(HGNC:TTR)) increases deg(a(CHEBI:"amyloid-beta")) + p(HGNC:CHRNA7) increases complex(p(FPLX:"G_beta"), p(FPLX:"G_gamma"), p(HGNC:CHRNA7)) - - - pmid:29626319 - - a(MESH:"Lymph Nodes") decreases a(CHEBI:"amyloid-beta") - + @@ -149548,23 +151250,13 @@

Statements

- - - pmid:29626319 - - complex(a(MESH:Erythrocytes), p(HGNC:CR1)) increases deg(a(CHEBI:"amyloid-beta")) - + - - - pmid:29626319 - - composite(a(CHEBI:"amyloid-beta"), a(MESH:"Serum Albumin")) decreases a(CHEBI:"amyloid-beta") - + @@ -149572,261 +151264,232 @@

Statements

- pmid:29626319 + pubmed:18986241 - a(MESH:Aminopeptidases) increases deg(p(HGNC:MAPT)) + p(HGNC:CHRNA7) increases complex(p(HGNC:APP), p(HGNC:CHRNA7)) - - - pmid:29626319 - - a(MESH:Thrombin) increases deg(p(HGNC:MAPT)) - - - - - pmid:29626319 - - a(MESH:tenuigenin) decreases a(CHEBI:"amyloid-beta polypeptide 40") - + - pmid:29626319 + pubmed:19721446 - a(MESH:tenuigenin) increases p(HGNC:PSMD7) + p(HGNC:CHRNA7) association a(MESH:Hippocampus) - pmid:29626319 + pubmed:19721446 - bp(GO:"cAMP-mediated signaling") increases p(HGNC:PSMD7) + p(HGNC:CHRNA7) association bp(GO:memory) - pmid:29626319 + pubmed:19721446 - a(CHEBI:wogonin) increases bp(GO:autophagy) + act(p(HGNC:CHRNA7)) decreases bp(GO:memory) - pmid:29626319 + pubmed:19721446 - a(CHEBI:wogonin) decreases a(CHEBI:"amyloid-beta") + p(HGNC:CHRNA7) association bp(GO:learning) - pmid:29626319 + pubmed:19721446 - a(CHEBI:wogonin) decreases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:CHRNA7) association a(CHEBI:clozapine) - pmid:29626319 + pubmed:22040696 - p(HGNC:NPAS4) increases bp(GO:autophagy) + p(HGNC:CHRNA7) regulates bp(GO:"chemical synaptic transmission") - pmid:29626319 + pubmed:22040696 - p(HGNC:NPAS4) increases deg(p(HGNC:MAPT)) + p(HGNC:CHRNA7) regulates bp(GO:"neuron-neuron synaptic transmission") - pmid:29626319 + pubmed:22040696 - p(HGNC:NPAS4) increases deg(p(HGNC:MAPT, pmod(Ph))) + p(HGNC:CHRNA7) association path(MESH:"Neurodegenerative Diseases") - - - pmid:29626319 - - a(CHEBI:statin) increases sec(p(HGNC:IDE)) - + - - - pmid:29626319 - - a(CHEBI:statin) increases deg(a(CHEBI:"amyloid-beta")) - + - pmid:29626319 + pubmed:22040696 - a(CHEBI:"omega-3 fatty acid") increases deg(a(CHEBI:"amyloid-beta")) + p(HGNC:CHRNA7) association p(HGNC:BDNF) - pmid:29626319 + pubmed:22040696 - a(CHEBI:"all-cis-5,8,11,14,17-icosapentaenoic acid") increases act(p(HGNC:IDE)) + tloc(p(HGNC:CHRNA7), fromLoc(GO:"cell surface"), toLoc(GO:endosome)) increases act(p(HGNC:CREB1), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) - - - pmid:29626319 - - a(CHEBI:"docosahexaenoic acid") increases act(p(HGNC:IDE)) - + + + - pmid:29626319 + pubmed:22040696 - a(CHEBI:"docosahexaenoic acid") increases deg(a(CHEBI:"amyloid-beta")) + p(HGNC:CHRNA7) negativeCorrelation path(MESH:Schizophrenia) - pmid:29626319 + pubmed:22040696 - a(CHEBI:"docosahexaenoic acid") increases act(a(MESH:Erythrocytes)) + p(HGNC:CHRNA7) decreases path(MESH:"Renal Insufficiency") - pmid:29626319 + pubmed:22040696 - a(CHEBI:atorvastatin) increases deg(a(CHEBI:"amyloid-beta")) + p(HGNC:CHRNA7) decreases bp(GO:"cytokine production") - pmid:29626319 + pubmed:22040696 - a(CHEBI:atorvastatin) increases sec(p(HGNC:MME)) + p(HGNC:CHRNA7) decreases bp(GO:"apoptotic process") - - - pmid:29626319 - - a(CHEBI:nobiletin) increases act(p(HGNC:MME)) - + - - - pmid:29626319 - - a(CHEBI:nobiletin) increases deg(a(CHEBI:"amyloid-beta")) - + + + - pmid:29626319 + pubmed:28901280 - a(CHEBI:"ginsenoside Rg1") increases act(p(HGNC:MME)) + p(HGNC:CHRNA7) association path(MESH:Neoplasms) - pmid:29626319 + pubmed:28901280 - a(CHEBI:"ginsenoside Rg1") decreases path(MESH:Tauopathies) + p(HGNC:CHRNA7) increases bp(GO:"intracellular receptor signaling pathway") - pmid:29626319 + pubmed:28901280 - a(MESH:"Granulocyte Colony-Stimulating Factor") increases act(p(HGNC:MME)) + p(HGNC:CHRNA7) increases bp(GO:"JAK-STAT cascade") + + - pmid:29626319 + pubmed:29191965 - a(MESH:"Granulocyte Colony-Stimulating Factor") decreases path(MESH:Tauopathies) + p(HGNC:CHRNA7) regulates bp(GO:"musculoskeletal movement") - pmid:29626319 + pubmed:29191965 - p(HGNC:ANXA1) increases deg(a(CHEBI:"amyloid-beta")) + p(HGNC:CHRNA7) regulates act(a(GO:synapse)) - pmid:29626319 + pubmed:29191965 - p(HGNC:ANXA1) increases act(p(HGNC:MME)) + p(HGNC:CHRNA7) association path(MESH:Tauopathies) + + - pmid:29626319 + pubmed:26813123 - a(CHEBI:minocycline) increases deg(a(CHEBI:"amyloid-beta")) + p(HGNC:CHRNA9) increases a(MESH:"Receptors, Nicotinic") @@ -149835,48 +151498,39 @@

Statements

+ + - pmid:29626319 + pubmed:28901280 - complex(a(MESH:"Chemokine CX3CL1"), p(HGNC:CX3CR1)) increases deg(a(CHEBI:"amyloid-beta")) + p(HGNC:CHRNA9) increases path(MESH:Neoplasms) + + - pmid:29626319 + pubmed:26813123 - a(CHEBI:"disodium cromoglycate") decreases a(CHEBI:"amyloid-beta") + p(HGNC:CHRNA10) increases a(MESH:"Receptors, Nicotinic") - - - pmid:29626319 - - a(CHEBI:oleocanthal) decreases a(CHEBI:"amyloid-beta") - + - - - pmid:29626319 - - a(CHEBI:oleocanthal) increases p(HGNC:LRP1) - + - - - pmid:29626319 - - a(CHEBI:oleocanthal) increases p(HGNC:ABCB1) - + + + @@ -149886,29 +151540,31 @@

Statements

- pmid:29238289 + pubmed:17009926 - complex(p(HGNC:MAPT), p(MESH:"Receptors, Muscarinic")) increases a(MESH:Calcium) + act(p(HGNC:CHRNB2)) increases bp(GO:"depolarization of postsynaptic membrane") - pmid:29238289 + pubmed:17009926 - complex(p(HGNC:MAPT), p(MESH:"Receptors, Muscarinic")) increases bp(GO:"apoptotic process") + p(HGNC:CHRNB2) increases bp(GO:"circadian sleep/wake cycle, wakefulness") + + - pmid:29238289 + pubmed:26813123 - rxn(reactants(p(HGNC:MAPT)), products(p(HGNC:MAPT, frag("1_421")), p(HGNC:MAPT, frag("421_*")))) increases sec(p(HGNC:MAPT)) + p(HGNC:CHRNB2) increases a(MESH:"Receptors, Nicotinic") @@ -149921,65 +151577,48 @@

Statements

- - - pmid:29238289 - - complex(p(HGNC:HSPA8), p(INTERPRO:"Chaperone DnaJ")) regulates sec(p(HGNC:MAPT)) - + - pmid:29238289 + pubmed:19721446 - p(HGNC:SNAP23) increases sec(p(HGNC:MAPT)) + p(HGNC:CHRNB2) association p(HGNCGENEFAMILY:Tubulins) - pmid:29238289 + pubmed:19721446 - p(HGNC:SNAP23) isA p(MESH:"SNARE Proteins") + p(HGNC:CHRNB2) association p(HGNC:DNM1) - pmid:29238289 + pubmed:19721446 - p(MESH:"SNARE Proteins") increases bp(GO:exocytosis) + p(HGNC:CHRNB2) association p(HGNCGENEFAMILY:"Clathrin subunits") - - - pmid:29238289 - - p(MESH:"rab GTP-Binding Proteins") regulates act(a(MESH:"Transport Vesicles")) - - - - - pmid:29238289 - - p(MESH:"rab GTP-Binding Proteins") regulates bp(MESH:"Membrane Fusion") - + - pmid:29238289 + pubmed:19721446 - a(MESH:"Transport Vesicles") association sec(p(HGNC:MAPT)) + p(HGNC:CHRNB2) increases act(a(CHEBI:nicotine)) @@ -149988,12 +151627,7 @@

Statements

- - - pmid:29980653 - - p(HGNC:PRNP, var("?")) positiveCorrelation path(MESH:"Prion Diseases") - + @@ -150003,32 +151637,20 @@

Statements

- pmid:29980653 + pubmed:26813123 - complex(a(HBP:"protein aggregates"), p(HGNCGENEFAMILY:Syndecans)) increases path(HBP:Neurodegeneration) + p(HGNC:CHRNB3) increases a(MESH:"Receptors, Nicotinic") - - - pmid:29980653 - - a(MESH:Glycosaminoglycans) association p(HGNCGENEFAMILY:Syndecans) - - - - - pmid:29980653 - - complex(a(HBP:"Tau aggregates"), a(MESH:Glycosaminoglycans)) increases a(HBP:"Tau fibrils") - + @@ -150038,22 +151660,20 @@

Statements

- pmid:29980653 + pubmed:19126755 - complex(a(HBP:"6-O-sulfated heparin"), a(HBP:"Tau aggregates")) increases a(HBP:"Tau fibrils") + p(HGNC:CHRNB4) association path(MESH:"Drug Tolerance") - - - pmid:29980653 + pubmed:26813123 - complex(a(HBP:"Tau aggregates"), p(HGNCGENEFAMILY:Syndecans, pmod(Sulf))) increases a(HBP:"Tau fibrils") + p(HGNC:CHRNB4) increases a(MESH:"Receptors, Nicotinic") @@ -150062,921 +151682,871 @@

Statements

- - - pmid:17493042 - - a(HBP:"microtubule-binding region") partOf p(HGNC:MAPT) - - - pmid:17493042 + pubmed:19721446 - a(HBP:"microtubule-binding region") equivalentTo p(HGNC:MAPT, frag("199_370")) + p(HGNC:CHRNB4) decreases act(a(CHEBI:nicotine)) - pmid:17493042 + pubmed:19721446 - a(HBP:"microtubule-binding region") increases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) + p(HGNC:CHRNB4) association path(MESH:Craving) - pmid:21757739 + pubmed:19721446 - a(HBP:"microtubule-binding region") partOf a(HBP:"assembly domain") + p(HGNC:CHRNB4) association path(MESH:Recurrence) - - - pmid:21757739 - - a(HBP:"microtubule-binding region") equivalentTo p(HGNC:MAPT, frag("244_369")) - + - - - pmid:1918161 - - a(HBP:"microtubule-binding region") equivalentTo p(HGNC:MAPT, frag("237_367")) - + - pmid:17493042 + pubmed:28901280 - p(HBP:"tubulin-binding repeat 2") partOf a(HBP:"microtubule-binding region") + p(HGNC:CHRNB4) positiveCorrelation bp(UBERON:0002138) - - - pmid:17493042 - - p(HBP:"tubulin-binding repeat 2") equivalentTo p(HBP:"Tau isoform F (441 aa)", frag("275_305")) - - - - - pmid:23407988 - - p(HBP:"tubulin-binding repeat 2") partOf p(HBP:"4R tau") - + - pmid:23407988 + pubmed:19126755 - p(HBP:"tubulin-binding repeat 2") partOf p(HBP:"3R tau") + p(CONSO:"alpha-4 beta-2 nAChR") negativeCorrelation path(MESH:Aging) - pmid:2123288 + pubmed:19126755 - p(HBP:"tubulin-binding repeat 2") association p(FPLX:CALM) + p(CONSO:"alpha-4 beta-2 nAChR") negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:17493042 + pubmed:19126755 - p(HBP:"tubulin-binding repeat 3") partOf a(HBP:"microtubule-binding region") + p(CONSO:"alpha-4 beta-2 nAChR") negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:17493042 + pubmed:19293145 - p(HBP:"tubulin-binding repeat 3") equivalentTo p(HBP:"Tau isoform F (441 aa)", frag("306_336")) + p(CONSO:"alpha-4 beta-2 nAChR") association path(MESH:"Alzheimer Disease") - pmid:23407988 + pubmed:19126755 - p(HBP:"tubulin-binding repeat 3") partOf p(HBP:"4R tau") + act(p(CONSO:"alpha-4 beta-2 nAChR")) decreases act(a(MESH:Interneurons)) - pmid:23407988 + pubmed:19126755 - p(HBP:"tubulin-binding repeat 3") partOf p(HBP:"3R tau") + act(p(CONSO:"alpha-4 beta-2 nAChR")) decreases bp(GO:"synaptic transmission, GABAergic") - pmid:17493042 + pubmed:19126755 - p(HBP:"tubulin-binding repeat 4") partOf a(HBP:"microtubule-binding region") + act(p(CONSO:"alpha-4 beta-2 nAChR")) decreases act(complex(GO:"voltage-gated calcium channel complex")) - pmid:17493042 + pubmed:19126755 - p(HBP:"tubulin-binding repeat 4") equivalentTo p(HBP:"Tau isoform F (441 aa)", frag("337_367")) + act(p(CONSO:"alpha-4 beta-2 nAChR", loc(MESH:"GABAergic Neurons"))) increases act(a(MESH:"Dopaminergic Neurons")) - pmid:17493042 + pubmed:21482353 - p(HBP:"tubulin-binding repeat 4") directlyIncreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) + p(CONSO:"alpha-4 beta-2 nAChR") positiveCorrelation a(MESH:"Dopaminergic Neurons") - pmid:23407988 + pubmed:19126755 - p(HBP:"tubulin-binding repeat 4") partOf p(HBP:"4R tau") + p(CONSO:"alpha-4 beta-2 nAChR") positiveCorrelation bp(GO:cognition) - pmid:17493042 + pubmed:21482353 - a(HBP:"projection domain") partOf p(HGNC:MAPT) + p(CONSO:"alpha-4 beta-2 nAChR") positiveCorrelation bp(GO:cognition) - pmid:17493042 + pubmed:26472524 - a(HBP:"projection domain") equivalentTo p(INTERPRO:"MAP2/Tau projection") + act(p(CONSO:"alpha-4 beta-2 nAChR")) increases bp(GO:"depolarization of postsynaptic membrane") - pmid:17493042 + pubmed:25514383 - a(HBP:"projection domain") equivalentTo p(HGNC:MAPT, frag("1_198")) + p(CONSO:"alpha-4 beta-2 nAChR") negativeCorrelation bp(GO:"calcium ion transport") - pmid:17493042 + pubmed:25514383 - p(INTERPRO:"MAP2/Tau projection") equivalentTo a(HBP:"projection domain") + act(p(CONSO:"alpha-4 beta-2 nAChR")) decreases bp(GO:"cellular calcium ion homeostasis") - pmid:8391280 + pubmed:25514383 - p(INTERPRO:"MAP2/Tau projection") association p(HGNC:DCTN1) + act(p(CONSO:"alpha-4 beta-2 nAChR")) increases path(CONSO:"mitochondrial dysfunction") - pmid:8391280 + pubmed:25514383 - p(INTERPRO:"MAP2/Tau projection") partOf p(HGNC:MAPT) + act(p(CONSO:"alpha-4 beta-2 nAChR")) increases bp(GO:"response to oxidative stress") - - - pmid:12551948 - - p(INTERPRO:"MAP2/Tau projection") isA p(HGNC:MAPT) - + - pmid:12551948 + pubmed:21482353 - p(INTERPRO:"MAP2/Tau projection") decreases bp(GO:"neuron projection development") + p(CONSO:"alpha-4 beta-2 nAChR") positiveCorrelation a(MESH:"GABAergic Neurons") - pmid:12551948 + pubmed:19126755 - p(INTERPRO:"MAP2/Tau projection") negativeCorrelation act(complex(GO:"plasma membrane")) + p(CONSO:"alpha-6 alpha-4 beta-2 beta-3 nAChR", loc(MESH:"Basal Ganglia")) association path(MESH:"Parkinson Disease") - pmid:17493042 + pubmed:19126755 - p(HBP:"Tau isoform F (441 aa)", frag("244_274")) equivalentTo p(HBP:"tubulin-binding repeat 1") + p(CONSO:"alpha-7-containing nAChR") increases bp(GO:"calcium ion transport into cytosol") - pmid:17493042 + pubmed:26472524 - p(HBP:"Tau isoform F (441 aa)", frag("275_305")) equivalentTo p(HBP:"tubulin-binding repeat 2") + p(CONSO:"alpha-7-containing nAChR") increases act(p(HGNC:CHRNA7)) + + - pmid:17493042 + pubmed:21482353 - p(HBP:"Tau isoform F (441 aa)", frag("306_336")) equivalentTo p(HBP:"tubulin-binding repeat 3") + p(CONSO:"alpha-7-containing nAChR") increases p(HGNC:SLC12A5) - pmid:17493042 + pubmed:21482353 - p(HBP:"Tau isoform F (441 aa)", frag("337_367")) equivalentTo p(HBP:"tubulin-binding repeat 4") + p(CONSO:"alpha-7-containing nAChR") increases p(HGNC:SLC12A5) - pmid:17493042 + pubmed:21482353 - p(HGNC:MAPT, frag("199_370")) equivalentTo a(HBP:"microtubule-binding region") + p(CONSO:"alpha-7-containing nAChR") association bp(GO:"macrophage activation") - pmid:17493042 + pubmed:21482353 - p(HGNC:MAPT, frag("1_198")) equivalentTo a(HBP:"projection domain") + p(CONSO:"alpha-7-containing nAChR") association bp(GO:"response to cytokine") - - - pmid:17493042 + pubmed:21787755 - p(FPLX:PRKG) increases p(HGNC:MAPT, pmod(Ph, Ser, 214)) + p(CONSO:"alpha-7-containing nAChR") decreases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) - pmid:17493042 + pubmed:21787755 - bp(MESH:Mitosis) increases p(HGNC:MAPT, pmod(Ph, Ser, 214)) + p(CONSO:"alpha-7-containing nAChR") regulates bp(GO:"excitatory chemical synaptic transmission") - pmid:21757739 + pubmed:21787755 - a(HBP:"assembly domain") equivalentTo p(HGNC:MAPT, frag("199_441")) + p(CONSO:"alpha-7-containing nAChR") association bp(GO:"neurotransmitter secretion") - pmid:21757739 + pubmed:21787755 - p(HGNC:MAPT, frag("199_441")) equivalentTo a(HBP:"assembly domain") + p(CONSO:"alpha-7-containing nAChR") association bp(GO:"maintenance of synapse structure") - pmid:21757739 + pubmed:21787755 - p(HGNC:MAPT, frag("244_369")) equivalentTo a(HBP:"microtubule-binding region") + p(CONSO:"alpha-7-containing nAChR") association bp(GO:"neuron projection maintenance") - pmid:21757739 + pubmed:21787755 - p(HGNC:MAPT, frag("370_441")) partOf a(HBP:"assembly domain") + p(CONSO:"alpha-7-containing nAChR") association bp(GO:"long-term synaptic potentiation") - pmid:21757739 + pubmed:21787755 - a(HBP:"proline-rich region 2") equivalentTo p(HGNC:MAPT, frag("199_244")) + p(CONSO:"alpha-7-containing nAChR") association path(MESH:Seizures) - pmid:21757739 + pubmed:21787755 - a(HBP:"proline-rich region 2") partOf a(HBP:"assembly domain") + p(CONSO:"alpha-7-containing nAChR") association bp(GO:"neuron death") - pmid:21757739 + pubmed:19126755 - a(HBP:"proline-rich region 2") partOf a(HBP:"proline-rich domain") + a(MESH:Manduca) association bp(GO:"establishment of blood-brain barrier") - pmid:21757739 + pubmed:19126755 - p(HGNC:MAPT, frag("199_244")) equivalentTo a(HBP:"proline-rich region 2") + p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits", var("?")) decreases bp(GO:"response to nicotine") - pmid:21757739 + pubmed:19126755 - a(HBP:"proline-rich domain") equivalentTo p(INTERPRO:"PSP, proline-rich") + a(TAXONOMY:8616) increases p(CONSO:alpha-Bungarotoxin) - pmid:21757739 + pubmed:19126755 - p(INTERPRO:"PSP, proline-rich") equivalentTo a(HBP:"proline-rich domain") + complex(a(MESH:alpha-cobratoxin), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + + - pmid:21757739 + pubmed:19126755 - a(HBP:"proline-rich region 1") equivalentTo p(HGNC:MAPT, frag("151_198")) + complex(a(CONSO:kappa-Bungarotoxin), p(CONSO:"alpha-3 beta-4 nAChR")) decreases act(p(CONSO:"alpha-3 beta-4 nAChR")) - - - pmid:21757739 - - a(HBP:"proline-rich region 1") partOf a(HBP:"proline-rich domain") - + + + - pmid:21757739 + pubmed:19126755 - a(HBP:"proline-rich region 1") partOf a(HBP:"projection domain") + act(p(CONSO:"alpha-3 beta-4 nAChR")) increases a(CHEBI:"calcium(2+)", loc(GO:intracellular)) - pmid:21757739 + pubmed:19126755 - p(HGNC:MAPT, frag("151_198")) equivalentTo a(HBP:"proline-rich region 1") + complex(a(CONSO:kappa-Bungarotoxin), p(HGNC:CHRNB4)) decreases act(p(HGNC:CHRNB4)) - pmid:21757739 + pubmed:19126755 - p(HGNC:MAPT, frag("1_151")) partOf a(HBP:"projection domain") + a(MESH:Conotoxins) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - - - - - pmid:27260836 + pubmed:19126755 - complex(p(HBP:"AP-2 complex"), p(HGNCGENEFAMILY:"Clathrin subunits")) positiveCorrelation bp(GO:"clathrin-dependent endocytosis") + a(MESH:Conotoxins) decreases act(p(HGNCGENEFAMILY:"Potassium voltage-gated channels")) - pmid:27260836 + pubmed:19126755 - p(HGNC:AP2M1) partOf p(HBP:"AP-2 complex") + a(MESH:Conotoxins) decreases act(p(MESH:"Voltage-Gated Sodium Channels")) - pmid:27260836 + pubmed:19721446 - p(HGNC:AP2B1) partOf p(HBP:"AP-2 complex") + a(MESH:Conotoxins) association complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) - pmid:27260836 + pubmed:19721446 - p(HGNC:AP2A1) partOf p(HBP:"AP-2 complex") + a(MESH:Conotoxins) decreases act(complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9))) - pmid:27260836 + pubmed:19721446 - p(HGNC:AP2A2) partOf p(HBP:"AP-2 complex") + a(MESH:Conotoxins) decreases path(MESH:Pain) - pmid:27260836 + pubmed:19126755 - p(HGNC:AP2S1) partOf p(HBP:"AP-2 complex") + p(HGNCGENEFAMILY:"Potassium voltage-gated channels") association a(CHEBI:anandamide) - pmid:27260836 + pubmed:19126755 - complex(GO:"Pick body") positiveCorrelation path(MESH:"Pick Disease of the Brain") + a(TAXONOMY:1163) increases a(CHEBI:"Anatoxin a") + + - pmid:24368848 + pubmed:19126755 - p(HBP:"Tau isoform F (441 aa)", var("p.Pro301Leu")) increases path(MESH:"Frontotemporal Dementia") + complex(a(CHEBI:"Anatoxin a"), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:23407988 + pubmed:19126755 - a(HBP:"ghost tangles") decreases complex(GO:"dendritic tree") + a(TAXONOMY:92736) increases a(CHEBI:epibatidine) - - - pmid:23407988 - - a(HBP:"Brodmann (1909) area 36") positiveCorrelation p(HBP:"4R tau") - + - pmid:23407988 + pubmed:19293145 - a(HBP:"CA1 field of hippocampus") positiveCorrelation p(HBP:"4R tau") + a(CHEBI:epibatidine) causesNoChange bp(GO:memory) - pmid:23407988 + pubmed:19293145 - a(HBP:"CA2 field of hippocampus") positiveCorrelation p(HBP:"4R tau") + a(CHEBI:epibatidine) causesNoChange bp(GO:cognition) - pmid:23407988 + pubmed:19293145 - a(HBP:"CA3 field of hippocampus") positiveCorrelation p(HBP:"4R tau") + a(CHEBI:epibatidine) causesNoChange path(MESH:"Plaque, Amyloid") - pmid:23407988 + pubmed:19293145 - a(HBP:"CA4 field of hippocampus") positiveCorrelation p(HBP:"4R tau") + a(CHEBI:epibatidine) causesNoChange bp(MESH:"Neurofibrillary Tangles") - - - pmid:23407988 - - act(complex(GO:dendrite)) positiveCorrelation complex(GO:"dendritic tree") - + - - - pmid:22253473 - - a(MESH:Neuropil) positiveCorrelation p(HBP:"Tau epitope, AT8") - + - - - pmid:23407988 - - complex(GO:"dendritic tree") positiveCorrelation act(complex(GO:dendrite)) - + - - - pmid:22142809 - - p(HBP:RAC1b) association p(HGNC:NGFR) - + - pmid:22142809 + pubmed:28132910 - p(HBP:RAC1b) isA p(HGNC:RAC1) + a(CHEBI:epibatidine) decreases complex(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"), a(PUBCHEM:16068384)) + + - pmid:22142809 + pubmed:19126755 - p(HBP:RAC1b) negativeCorrelation p(HGNC:CAV2) + complex(a(CHEBI:epibatidine), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:22142809 + pubmed:19126755 - p(HBP:RAC1b) negativeCorrelation p(HGNC:GNB4) + complex(a(CHEBI:epibatidine), p(CONSO:"alpha-4 beta-2 nAChR")) increases act(p(CONSO:"alpha-4 beta-2 nAChR")) - pmid:22142809 + pubmed:19126755 - p(HBP:RAC1b) negativeCorrelation p(HGNC:LIPA) + complex(a(MESH:methyllycaconitine), p(HGNC:CHRNA7)) decreases act(p(HGNC:CHRNA7, loc(MESH:Muscles))) - - - pmid:22142809 - - p(HBP:RAC1b) positiveCorrelation a(HBP:"cerebral cortex") - + + + - pmid:27087442 + pubmed:19293145 - act(p(HBP:RAC1b)) decreases bp(GO:"neuron death") + a(MESH:methyllycaconitine) decreases act(p(HGNC:CHRNA7)) - pmid:27796283 + pubmed:19293145 - act(p(HGNC:RAC1)) regulates bp(GO:"dendritic spine development") + a(MESH:methyllycaconitine) decreases act(p(HGNC:CHRNA7)) - pmid:22142809 + pubmed:19293145 - p(HGNC:CAV2) negativeCorrelation p(HBP:RAC1b) + a(MESH:methyllycaconitine) increases bp(MESH:Neuroprotection) - pmid:22142809 + pubmed:25881725 - p(HGNC:GNB4) negativeCorrelation p(HBP:RAC1b) + a(MESH:methyllycaconitine) decreases act(a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide")) - pmid:22142809 + pubmed:25881725 - a(HBP:"cerebral cortex") positiveCorrelation p(HBP:RAC1b) + a(MESH:methyllycaconitine) decreases act(a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide")) - pmid:6543144 + pubmed:25881725 - complex(GO:microtubule) association p(HGNC:MAPT) + a(MESH:methyllycaconitine) decreases act(a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide")) - pmid:10464280 + pubmed:25881725 - complex(GO:microtubule) association p(HGNC:MAPT) + a(MESH:methyllycaconitine) decreases act(a(CHEBI:galanthamine)) - pmid:19491104 + pubmed:25881725 - complex(GO:microtubule) association p(HGNC:KIF5B) + a(MESH:methyllycaconitine) decreases act(a(CHEBI:galanthamine)) - pmid:10464280 + pubmed:25881725 - act(complex(GO:microtubule)) positiveCorrelation p(HBP:"microtubule-binding region") + a(MESH:methyllycaconitine) decreases act(a(CHEBI:galanthamine)) - pmid:10464280 + pubmed:25881725 - complex(GO:microtubule) association p(HGNC:PPP2CA) + a(MESH:methyllycaconitine) decreases act(p(MGI:Chrna7)) - pmid:10464280 + pubmed:25881725 - act(complex(GO:microtubule)) directlyDecreases act(complex(GO:"protein phosphatase type 2A complex")) + a(MESH:methyllycaconitine) decreases act(p(MGI:Chrna7)) - pmid:18500754 + pubmed:25881725 - act(complex(GO:microtubule)) negativeCorrelation act(p(HGNC:HSPA8)) + a(MESH:methyllycaconitine) decreases p(MGI:Chrna7) - pmid:18500754 + pubmed:25881725 - complex(GO:microtubule) association p(INTERPRO:"Heat shock protein 70 family") + a(MESH:methyllycaconitine) decreases path(MESH:"Spatial Memory") - pmid:20133804 + pubmed:25881725 - complex(GO:microtubule) positiveCorrelation bp(GO:"microtubule polymerization") + a(MESH:methyllycaconitine) causesNoChange r(MGI:Chrna7) - pmid:1918161 + pubmed:19721446 - p(HGNC:MAPT, frag("237_367")) directlyIncreases complex(GO:microtubule) + a(MESH:methyllycaconitine) decreases act(a(DRUGBANK:Facinicline)) - pmid:1918161 + pubmed:19126755 - p(HGNC:MAPT, frag("237_367")) partOf p(HGNC:MAPT) + complex(a(MESH:methyllycaconitine), p(HGNC:CHRNA6)) decreases act(p(HGNC:CHRNA6, loc(MESH:Muscles))) - pmid:1918161 + pubmed:19126755 - p(HGNC:MAPT, frag("237_367")) equivalentTo a(HBP:"microtubule-binding region") + complex(a(MESH:methyllycaconitine), p(HGNC:CHRNA3)) decreases act(p(HGNC:CHRNA3, loc(MESH:Muscles))) - pmid:1918161 + pubmed:19126755 - complex(GO:axon) positiveCorrelation p(HGNC:MAPT) + r(HGNC:CHRNA3) association p(HGNCGENEFAMILY:"ETS transcription factor family") - pmid:26671985 + pubmed:27758088 - act(complex(GO:axon)) negativeCorrelation p(HBP:"phosphatase-activating domain") + r(HGNC:CHRNA3) association a(MESH:Brain) - pmid:26671985 + pubmed:27758088 - act(complex(GO:axon)) negativeCorrelation path(HBP:neurotoxicity) + r(HGNC:CHRNA3) association r(HGNC:CHRNA5) - pmid:1918161 + pubmed:27758088 - complex(GO:"neuron projection") positiveCorrelation p(HGNC:MAPT) + r(HGNC:CHRNA3) association r(MESH:"long non-coding RNA RP11-650L12.2, human") + + - pmid:17187063 + pubmed:19126755 - p(HBP:"Tau isoform F (441 aa)", var("p.Val337Met")) increases a(HBP:Neurodegeneration) + r(HGNC:CHRNB4) association p(HGNCGENEFAMILY:"ETS transcription factor family") - pmid:17187063 + pubmed:27758088 - a(HBP:Neurodegeneration) positiveCorrelation complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) + r(HGNC:CHRNB4) association a(UBERON:0000010) - pmid:6543144 + pubmed:21787755 - complex(GO:neurofilament) association p(HGNC:MAPT) + r(HGNC:CHRNB4) association r(HGNC:CHRNA4) + + - pmid:2446784 + pubmed:21787755 - complex(GO:"polysomal ribosome") association p(HGNC:MAPT) + r(HGNC:CHRNA4) association r(HGNC:CHRNB4) + + - pmid:11812770 + pubmed:27758088 - p(HGNC:MAPT, frag("1_244")) partOf p(HGNC:MAPT) + r(HGNC:CHRNA5) association a(MESH:Brain) + + + pubmed:27758088 + + r(HGNC:CHRNA5) association r(HGNC:CHRNA3) + + - pmid:11812770 + pubmed:27758088 - complex(p(HGNC:GSK3B), p(HGNC:MAPT)) positiveCorrelation p(HGNC:GSK3B) + r(HGNC:CHRNA5) association r(MESH:"long non-coding RNA RP11-650L12.2, human") @@ -150985,99 +152555,99 @@

Statements

- pmid:11812770 + pubmed:21787755 - complex(p(HGNC:GSK3B), p(HGNC:MAPT)) positiveCorrelation p(HGNC:MAPT) + r(HGNC:CHRNA6) association path(MESH:Reward) - pmid:18680553 + pubmed:21787755 - p(HGNC:MAPT, frag("223_226")) association p(HGNC:FYN) + r(HGNC:CHRNA6) association bp(MESH:"Drug Interactions") - pmid:18680553 + pubmed:21787755 - p(HGNC:MAPT, frag("223_226")) partOf p(HGNC:MAPT) + r(HGNC:CHRNA6) association tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:18680553 + pubmed:19126755 - bp(GO:myelination) positiveCorrelation complex(p(HGNC:FYN), p(HGNC:MAPT)) + a(MESH:Fetus) increases r(HGNC:CHRNA3, loc(MESH:Brain)) - pmid:18680553 + pubmed:19126755 - bp(GO:myelination) association p(HGNC:MAPT) + path(MESH:"Trauma, Nervous System") increases r(HGNC:CHRNA3, loc(MESH:Brain)) - pmid:26751493 + pubmed:24561250 - bp(GO:myelination) association p(HGNC:FYN) + path(MESH:"Trauma, Nervous System") increases path(MESH:"Alzheimer Disease") - pmid:18467332 + pubmed:24561250 - p(HGNC:SRC, frag("84_145")) association p(HGNC:MAPT) + path(MESH:"Trauma, Nervous System") increases complex(GO:"inflammasome complex") - pmid:18467332 + pubmed:19126755 - p(HGNC:SRC, frag("84_145")) partOf p(HGNC:SRC) + a(MESH:Adult) decreases r(HGNC:CHRNA3, loc(MESH:Neurons)) - pmid:18467332 + pubmed:19126755 - p(HGNC:SRC, frag("84_145")) equivalentTo p(INTERPRO:"SH3 domain") + a(MESH:Adult) increases r(HGNC:CHRNA4, loc(MESH:Neurons)) - pmid:18467332 + pubmed:19126755 - p(INTERPRO:"SH3 domain") equivalentTo p(HGNC:SRC, frag("84_145")) + r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") increases bp(CONSO:"nAChR assembly") - pmid:18467332 + pubmed:19126755 - p(INTERPRO:"SH3 domain") equivalentTo p(HGNC:PLCG1, frag("790_851")) + act(complex(p(HGNC:JUN), p(HGNC:SP1)), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases r(HGNC:CHRNB4) @@ -151088,318 +152658,333 @@

Statements

- pmid:18467332 + pubmed:18494933 - p(HGNC:PLCG1, frag("790_851")) association p(HGNC:MAPT) + p(HGNC:JUN) partOf p(FPLX:AP1) - pmid:18467332 + pubmed:19126755 - p(HGNC:PLCG1, frag("790_851")) partOf p(HGNC:PLCG1) + act(p(HGNC:SOX10)) increases r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:18467332 + pubmed:19126755 - p(HGNC:PLCG1, frag("790_851")) equivalentTo p(INTERPRO:"SH3 domain") + composite(p(HGNC:CHRNA7), p(HGNC:NGF)) increases r(HGNC:CHRNB4) - - - - - pmid:18467332 + pubmed:19126755 - p(HGNC:GRB2, frag("1_57")) association p(HGNC:MAPT) + p(HGNCGENEFAMILY:"ETS transcription factor family") association r(HGNC:CHRNA3) - pmid:18467332 + pubmed:19126755 - p(HGNC:GRB2, frag("1_57")) isA complex(p(HGNC:GRB2), p(HGNC:MAPT)) + p(HGNCGENEFAMILY:"ETS transcription factor family") association r(HGNC:CHRNB4) - pmid:18467332 + pubmed:19126755 - p(HGNC:GRB2, frag("1_57")) partOf p(HGNC:GRB2) + complex(p(HGNC:CHRNA5), p(HGNC:CHRNA7)) association p(HGNC:CHRNA7) - pmid:18467332 + pubmed:19126755 - p(HGNC:GRB2, frag("1_57")) equivalentTo p(INTERPRO:"GRB2, N-terminal SH3 domain") + complex(p(HGNC:CHRNA7), p(HGNC:CHRNB2)) association p(HGNC:CHRNA7) - - - - - pmid:18467332 + pubmed:26979166 - complex(p(HGNC:GRB2), p(HGNC:MAPT)) association p(HGNC:MAPT) + complex(p(HGNC:CHRNA7), p(HGNC:CHRNB2)) increases bp(GO:"pore complex assembly") - pmid:18467332 + pubmed:26979166 - p(INTERPRO:"GRB2, N-terminal SH3 domain") equivalentTo p(HGNC:GRB2, frag("1_57")) + complex(p(HGNC:CHRNA7), p(HGNC:CHRNB2)) increases tloc(p(MESH:"Cytochromes c"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:18467332 + pubmed:25514383 - p(INTERPRO:"GRB2, N-terminal SH3 domain") equivalentTo p(HGNC:PIK3R1, frag("3_79")) + complex(p(HGNC:CHRNA7), p(HGNC:CHRNB2)) increases p(CONSO:"alpha-7 beta-2 nAChR") - pmid:18467332 + pubmed:25514383 - p(HGNC:PIK3R1, frag("3_79")) association p(HGNC:MAPT) + complex(p(HGNC:CHRNA7), p(HGNC:CHRNB2)) increases tloc(p(CONSO:"alpha-7 beta-2 nAChR"), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) - pmid:18467332 + pubmed:19126755 - p(HGNC:PIK3R1, frag("3_79")) partOf p(HGNC:PIK3R1) + complex(p(HGNC:CHRNA7), p(HGNC:CHRNB3)) association p(HGNC:CHRNA7) - pmid:18467332 + pubmed:19126755 - p(HGNC:PIK3R1, frag("3_79")) equivalentTo p(INTERPRO:"GRB2, N-terminal SH3 domain") + a(MESH:Muscles) association complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) - - - pmid:18467332 + pubmed:19126755 - p(HGNC:PIK3R1) isA complex(p(HGNC:MAPT), p(HGNC:PIK3R1)) + a(MESH:Muscles) association complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE), loc(MESH:"Neuromuscular Junction")) - - - - - pmid:19491104 + pubmed:19126755 - bp(GO:"vesicle-mediated transport") positiveCorrelation act(complex(GO:"kinesin complex")) + a(MESH:Muscles) increases r(HGNC:CHRNA1) - pmid:19491104 + pubmed:19126755 - p(MGI:Mapk8ip1) association p(MGI:Mapt, pmod(Ph)) + a(MESH:Muscles) increases r(HGNC:CHRNB1) - pmid:19491104 + pubmed:19126755 - act(p(MGI:Mapk8ip1)) negativeCorrelation p(MGI:Mapt, pmod(Ph)) + a(MESH:Muscles) increases r(HGNC:CHRND) - pmid:19491104 + pubmed:19126755 - act(p(MGI:Klc1)) negativeCorrelation p(MGI:Mapt, pmod(Ph)) + a(MESH:Muscles) increases r(HGNC:CHRNG) - - - + + + pubmed:19126755 + + complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) association a(MESH:Muscles) + - + + + pubmed:19126755 + + complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG), loc(GO:"cell surface")) + - pmid:10464280 + pubmed:23038257 - rxn(reactants(p(HGNC:MAPT, pmod(Ph))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT))) negativeCorrelation p(HGNC:MAPT, pmod(Ph)) + complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) association a(CHEBI:chlorpromazine) - + + + pubmed:26813123 + + complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) increases p(FPLX:CHRN) + - pmid:18500754 + pubmed:19126755 - p(INTERPRO:"Heat shock protein 70kD, C-terminal domain superfamily") association p(HBP:"microtubule-binding region") + complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE), loc(MESH:"Neuromuscular Junction")) association a(MESH:Muscles) - pmid:19363271 + pubmed:19126755 - a(CHEBI:juglone) increases bp(GO:"neurofibrillary tangle assembly") + complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE)) decreases deg(complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE))) - - - + + + pubmed:19126755 + + bp(GO:"depolarization of postsynaptic membrane") increases r(HGNC:CHRNE) + - pmid:14612456 + pubmed:19126755 - complex(p(HGNC:MAPT, pmod(Ph)), p(HGNC:STUB1), p(HGNC:UBE2D2)) directlyIncreases p(HGNC:MAPT, pmod(Ub)) + bp(GO:"depolarization of postsynaptic membrane") increases act(complex(GO:"voltage-gated calcium channel complex")) - - - + + + pubmed:17009926 + + bp(GO:"depolarization of postsynaptic membrane") increases bp(GO:"regulation of action potential firing rate") + - pmid:8391280 + pubmed:26472524 - p(FPLX:Ubiquitin) association p(HBP:"microtubule-binding region") + bp(GO:"depolarization of postsynaptic membrane") increases bp(GO:"regulation of action potential firing rate") - pmid:8391280 + pubmed:17009926 - p(FPLX:Ubiquitin) directlyIncreases p(HGNC:MAPT, pmod(Ub)) + bp(GO:"depolarization of postsynaptic membrane") increases bp(GO:"long-term synaptic potentiation") - pmid:8391280 + pubmed:26472524 - act(p(INTERPRO:"Dynein associated protein")) positiveCorrelation complex(a(MESH:Microtubules), p(INTERPRO:"Dynein associated protein")) + bp(GO:"depolarization of postsynaptic membrane") decreases a(MESH:"Cations, Divalent") - + + + pubmed:28901280 + + bp(GO:"depolarization of postsynaptic membrane") association p(MESH:"Receptors, Nicotinic") + - pmid:8391280 + pubmed:19126755 - complex(a(MESH:Microtubules), p(INTERPRO:"Dynein associated protein")) positiveCorrelation act(p(INTERPRO:"Dynein associated protein")) + r(HGNC:CHRNE) decreases complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) - pmid:8391280 + pubmed:19126755 - g(DBSNP:rs63750424) positiveCorrelation path(MESH:"Frontotemporal Dementia") + r(HGNC:CHRNE) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE)) - pmid:8391280 + pubmed:19126755 - g(DBSNP:rs63750424) negativeCorrelation complex(p(HGNC:DCTN1), p(HGNC:MAPT)) + composite(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRNG), loc(GO:"endoplasmic reticulum")) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRNG)) - + + + pubmed:19126755 + + complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRNG), loc(GO:"endoplasmic reticulum")) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) + - pmid:16176937 + pubmed:19126755 - p(RGD:Klc1) isA complex(p(RGD:Klc1), p(RGD:Mapt)) + complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG), loc(GO:"endoplasmic reticulum")) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) - pmid:16176937 + pubmed:19126755 - p(RGD:Klc1) isA p(INTERPRO:"Kinesin motor domain") + composite(complex(p(HGNC:CHRNA1), p(HGNC:CHRND)), complex(p(HGNC:CHRNA1), p(HGNC:CHRNG))) increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG)) @@ -151410,45 +152995,54 @@

Statements

- pmid:16176937 + pubmed:19126755 - p(RGD:Klc2) isA complex(p(RGD:Klc2), p(RGD:Mapt)) + a(MESH:Oocytes) association complex(p(HGNC:CHRNA4), p(HGNC:CHRNA7), p(HGNC:CHRNB2)) + + + + + + + pubmed:19126755 + + complex(p(HGNC:CHRNA4), p(HGNC:CHRNA7), p(HGNC:CHRNB2)) association a(MESH:Oocytes) - pmid:16176937 + pubmed:19126755 - p(RGD:Klc2) isA p(INTERPRO:"Kinesin motor domain") + a(MESH:Ganglia) increases p(CONSO:"alpha-3 beta-4 nAChR") - pmid:16176937 + pubmed:19126755 - p(INTERPRO:"Kinesin motor domain") association p(RGD:Snca) + a(MESH:Ganglia) increases p(CONSO:"alpha-4 beta-2 nAChR") - pmid:16176937 + pubmed:19126755 - p(RGD:Snca) isA complex(p(FPLX:"Cytoplasmic_dynein"), p(RGD:Snca)) + composite(a(MESH:"HEK293 Cells"), g(HGNC:CHRNA7)) increases r(HGNC:CHRNA7) - pmid:16176937 + pubmed:19126755 - p(RGD:Snca) association p(INTERPRO:"Kinesin motor domain") + composite(a(MESH:"HEK293 Cells"), g(HGNC:CHRNA7)) decreases act(p(HGNC:CHRNA7)) @@ -151459,178 +153053,164 @@

Statements

- pmid:16176937 + pubmed:19126755 - p(FPLX:"Cytoplasmic_dynein") isA complex(p(FPLX:"Cytoplasmic_dynein"), p(RGD:Snca)) + g(HGNC:CHRNA7) increases p(HGNC:CHRNA7) - pmid:10391244 + pubmed:19126755 - p(HGNC:PIN1, frag("5_39")) association p(HGNC:MAPT, pmod(Ph, Thr, 231)) + g(HGNC:CHRNA7) association path(MESH:"Sensory Gating") - pmid:10391244 + pubmed:27190210 - act(p(HGNC:PIN1, frag("5_39"))) positiveCorrelation complex(p(HGNC:MAPT, pmod(Ph, Thr, 231)), p(HGNC:PIN1, frag("5_39"))) + g(HGNC:CHRNA7) association bp(GO:cognition) - - - - - pmid:10391244 + pubmed:27190210 - complex(p(HGNC:MAPT, pmod(Ph, Thr, 231)), p(HGNC:PIN1, frag("5_39"))) positiveCorrelation act(p(HGNC:PIN1, frag("5_39"))) + g(HGNC:CHRNA7) association path(DOID:schizophrenia) - pmid:10391244 + pubmed:27190210 - complex(p(HGNC:MAPT, pmod(Ph, Thr, 231)), p(HGNC:PIN1, frag("5_39"))) association complex(GO:"neurofibrillary tangle") + g(HGNC:CHRNA7) association path(MESH:"Intellectual Disability") - pmid:10391244 + pubmed:27190210 - complex(p(HGNC:MAPT, pmod(Ph, Thr, 231)), p(HGNC:PIN1, frag("5_39"))) increases act(p(HGNC:MAPT)) + g(HGNC:CHRNA7) association path(DOID:"bipolar disorder") - pmid:10391244 + pubmed:27190210 - p(HGNC:PIN1, var("p.Tyr23Ala")) decreases act(p(HGNC:PIN1, frag("5_39"))) + g(HGNC:CHRNA7) association path(DOID:"autism spectrum disorder") - pmid:20133804 + pubmed:27190210 - p(RGD:Fkbp4) positiveCorrelation p(RGD:Mapt, pmod(Ph)) + g(HGNC:CHRNA7) association path(DOID:"attention deficit hyperactivity disorder") - pmid:20133804 + pubmed:27190210 - p(RGD:Fkbp4) isA complex(p(RGD:Fkbp4), p(RGD:Mapt, pmod(Ph))) + g(HGNC:CHRNA7) association path(DOID:epilepsy) - pmid:20133804 + pubmed:27190210 - p(RGD:Fkbp4) decreases act(p(RGD:Mapt)) + g(HGNC:CHRNA7) association path(DOID:"Alzheimer's disease") - pmid:20133804 + pubmed:27190210 - p(RGD:Fkbp4) negativeCorrelation bp(GO:"neuron projection development") + g(HGNC:CHRNA7) negativeCorrelation bp(GO:"sensory processing") - - - pmid:20133804 + pubmed:18986241 - p(HGNC:FKBP4, frag("270_386")) association p(FPLX:HSP90) + r(HGNC:CHRNA7) negativeCorrelation path(MESH:Cognition) - pmid:20133804 + pubmed:18986241 - p(HGNC:FKBP4, frag("270_386")) isA p(HGNC:FKBP4) + r(HGNC:CHRNA7) regulates act(a(MESH:"Cholinergic Neurons")) - pmid:20133804 + pubmed:18986241 - p(HGNC:FKBP4, frag("270_386")) isA complex(p(FPLX:HSP90), p(HGNC:FKBP4)) + r(HGNC:CHRNA7) increases path(MESH:"Nerve Degeneration") - - - - - pmid:20071522 + pubmed:11230871 - complex(p(HGNC:AHSA1), p(HGNC:MAPT)) negativeCorrelation p(HGNC:FKBP5) + r(HGNC:CHRNA7) positiveCorrelation path(MESH:"Alzheimer Disease") - - - - - pmid:2123288 + pubmed:19126755 - p(FPLX:CALM) association p(HBP:"tubulin-binding repeat 2") + a(MESH:"Cell Line") regulates r(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:2123288 + pubmed:19126755 - act(p(FPLX:CALM)) increases complex(a(CHEBI:"calcium(2+)"), p(FPLX:CALM)) + a(MESH:"Cell Line") regulates complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) - pmid:2123288 + pubmed:19126755 - act(p(FPLX:CALM)) decreases bp(GO:"microtubule polymerization") + composite(g(HGNC:CHRNA4), g(HGNC:CHRNB2)) increases complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) @@ -151639,12 +153219,9 @@

Statements

- - - pmid:2123288 - - complex(a(CHEBI:"calcium(2+)"), p(FPLX:CALM)) isA complex(a(CHEBI:"calcium(2+)"), p(FPLX:CALM), p(HGNC:MAPT)) - + + + @@ -151654,1742 +153231,1742 @@

Statements

- pmid:2123288 + pubmed:25514383 - complex(p(FPLX:CALM), p(HGNC:MAPT)) isA complex(a(CHEBI:"calcium(2+)"), p(FPLX:CALM), p(HGNC:MAPT)) + complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) increases p(CONSO:"alpha-4 beta-2 nAChR") - - - + + + pubmed:19721446 + + complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) association a(MESH:"Dopaminergic Neurons") + - pmid:2123288 + pubmed:21787755 - complex(a(CHEBI:"calcium(2+)"), p(FPLX:CALM), p(HGNC:MAPT)) negativeCorrelation act(p(HGNC:MAPT)) + complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) association path(MESH:"Tobacco Use Disorder") - pmid:2833519 + pubmed:21787755 - p(HGNC:S100B) association p(HGNC:MAPT) + complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) association path(MESH:Reward) - pmid:2833519 + pubmed:21787755 - p(HGNC:S100B) isA complex(p(HGNC:MAPT), p(HGNC:S100B)) + complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) association path(MESH:"Alzheimer Disease") - pmid:2833519 + pubmed:21787755 - act(p(HGNC:S100B)) decreases act(p(FPLX:"CAMK2_family")) + complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) association path(MESH:Epilepsy) - pmid:18494933 + pubmed:19126755 - p(HGNC:S100B) increases act(p(HGNC:AGER)) + p(HGNC:CHRNA7, frag("23_46")) increases complex(p(HGNC:CHRNA7), p(HGNC:CHRNA7)) - pmid:18494933 + pubmed:19126755 - p(HGNC:S100B) increases p(FPLX:JNK) + p(MESH:"Cysteine Loop Ligand-Gated Ion Channel Receptors") isA p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:18494933 + pubmed:19126755 - p(HGNC:S100B) increases act(p(FPLX:JNK)) + a(MESH:"Endoplasmic Reticulum") regulates bp(CONSO:"nAChR assembly") - pmid:18494933 + pubmed:19126755 - p(HGNC:S100B) decreases bp(GO:"Wnt signaling pathway") + a(MESH:"Endoplasmic Reticulum") regulates p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:18494933 + pubmed:19126755 - p(HGNC:S100B) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + a(MESH:"Endoplasmic Reticulum") increases deg(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits", loc(GO:"endoplasmic reticulum"))) - - - pmid:2833519 + pubmed:19126755 - complex(p(HGNC:MAPT), p(HGNC:S100B)) decreases act(p(FPLX:"CAMK2_family")) + bp(CONSO:"nAChR assembly") increases p(CONSO:"alpha-3 beta-4 nAChR", loc(GO:"cell surface")) - pmid:2833519 + pubmed:19126755 - act(p(FPLX:"CAMK2_family")) increases p(HGNC:MAPT, pmod(Ph)) + bp(CONSO:"nAChR assembly") increases complex(p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG), loc(GO:"cell surface")) - pmid:12714745 + pubmed:19126755 - g(DBSNP:rs104893877) positiveCorrelation complex(GO:"neurofibrillary tangle") + a(CHEBI:"proteasome inhibitor") decreases deg(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits", loc(GO:"endoplasmic reticulum"))) - pmid:12714745 + pubmed:19126755 - g(DBSNP:rs104893877) positiveCorrelation complex(GO:"Lewy body") + a(CHEBI:"proteasome inhibitor") increases bp(CONSO:"nAChR assembly") - pmid:12714745 + pubmed:29626319 - complex(GO:"Lewy body") positiveCorrelation g(DBSNP:rs104893877) + a(CHEBI:"proteasome inhibitor") increases bp(GO:autophagy) - - - - - pmid:12714745 + pubmed:29626319 - composite(p(HGNC:MAPT), p(HGNC:SNCA)) increases complex(GO:"neurofibrillary tangle") + a(CHEBI:"proteasome inhibitor") decreases p(HGNC:MAPT) - pmid:12714745 + pubmed:29626319 - composite(p(HGNC:MAPT), p(HGNC:SNCA)) increases complex(GO:"Lewy body") + a(CHEBI:"proteasome inhibitor") increases p(HGNC:BAG3) - - - - - pmid:12551948 + pubmed:21787755 - act(complex(GO:"plasma membrane")) negativeCorrelation p(INTERPRO:"MAP2/Tau projection") + p(CONSO:"alpha-3 beta-2 nAChR") regulates tloc(a(CHEBI:"gamma-aminobutyric acid"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:21339331 + pubmed:19126755 - p(HBP:"Tau isoform F (441 aa)", var("p.Arg406Tyr")) decreases p(HGNC:MAPT, pmod(Ph, Thr, 205)) + composite(a(CHEBI:nicotine), g(HGNC:CHRNA4)) increases p(HGNC:CHRNA4) - pmid:21339331 + pubmed:19126755 - p(HBP:"Tau isoform F (441 aa)", var("p.Arg406Tyr")) decreases p(HGNC:MAPT, pmod(Ph, Thr, 212)) + composite(a(CHEBI:nicotine), g(HGNC:CHRNA6)) increases p(HGNC:CHRNA6) + + - pmid:21339331 + pubmed:19126755 - p(HBP:"Tau isoform F (441 aa)", var("p.Arg406Tyr")) decreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + composite(a(CHEBI:nicotine), g(HGNC:CHRNB2)) increases p(HGNC:CHRNB2) - pmid:21339331 + pubmed:19126755 - p(HBP:"Tau isoform F (441 aa)", var("p.Arg406Tyr")) decreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + composite(a(CHEBI:nicotine), g(HGNC:CHRNB3)) increases p(HGNC:CHRNB3) - - - pmid:21339331 - - p(HBP:"Tau isoform F (441 aa)", var("p.Arg406Tyr")) decreases complex(a(MESH:"Cell Membrane"), p(HGNC:ANXA2), p(HGNC:MAPT)) - + - pmid:17078951 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph, Thr, 212)) negativeCorrelation p(FPLX:PKA) + a(MESH:Interneurons) increases p(HGNC:SST) - pmid:22072628 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph, Thr, 212)) partOf p(HBP:"proline-rich region 2", pmod(Ph)) + a(MESH:Interneurons) increases p(HGNC:NPY) - pmid:21339331 + pubmed:30027901 - p(HGNC:ANXA2) association p(HGNC:MAPT) + a(MESH:Interneurons) increases p(HGNC:NQO1) - pmid:21339331 + pubmed:19126755 - p(HGNC:ANXA2) association a(MESH:"Cell Membrane") + tloc(a(CHEBI:"gamma-aminobutyric acid"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) increases bp(GO:"hyperpolarization of postsynaptic membrane") - pmid:21339331 + pubmed:21482353 - p(HGNC:ANXA2) isA complex(a(MESH:"Cell Membrane"), p(HGNC:ANXA2), p(HGNC:MAPT)) + a(CHEBI:"gamma-aminobutyric acid") increases act(p(HGNC:GABBR1)) - - - - - - - pmid:18096814 + pubmed:21482353 - a(CHEBI:"2-bromohexadecanoic acid") decreases p(MGI:Fyn, pmod(Palm)) + a(CHEBI:"gamma-aminobutyric acid") increases act(p(HGNC:GABBR2)) - pmid:18096814 + pubmed:21482353 - a(CHEBI:"2-bromohexadecanoic acid") negativeCorrelation p(MGI:Mapt) + a(CHEBI:"gamma-aminobutyric acid") decreases tloc(a(CHEBI:"glutamate(2-)"), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) + + - pmid:18096814 + pubmed:19126755 - a(CHEBI:"2-bromohexadecanoic acid") negativeCorrelation p(MGI:Fyn) + bp(GO:"action potential initiation") decreases a(MESH:"Electric Stimulation", loc(GO:"Schaffer axon collateral")) - pmid:18096814 + pubmed:19126755 - p(MGI:Fyn, pmod(Palm)) increases tloc(p(MGI:Fyn), fromLoc(GO:cytoplasm), toLoc(GO:"membrane raft")) + bp(GO:"action potential initiation") increases act(a(MESH:"Perforant Pathway")) - pmid:21131359 + pubmed:26813123 - bp(MESH:"Hot Temperature") increases complex(a(CHEBI:"double-stranded DNA"), p(HGNC:MAPT)) + bp(GO:"action potential initiation") increases tloc(a(CHEBI:choline), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:21131359 + pubmed:26813123 - bp(MESH:"Hot Temperature") increases tloc(p(HGNC:MAPT), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) + bp(GO:"action potential initiation") increases tloc(a(CHEBI:choline), fromLoc(GO:"synaptic cleft"), toLoc(MESH:"Cholinergic Neurons")) - pmid:21131359 + pubmed:26813123 - bp(MESH:"Hot Temperature") negativeCorrelation p(HGNC:MAPT) + bp(GO:"action potential initiation") increases a(CHEBI:acetylcholine) - pmid:21131359 + pubmed:26813123 - bp(MESH:"Hot Temperature") decreases a(CHEBI:"double-stranded DNA") + bp(GO:"action potential initiation") increases a(CHEBI:acetylcholine) - pmid:8226987 + pubmed:26813123 - bp(MESH:"Hot Temperature") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + bp(GO:"action potential initiation") association complex(a(GO:"plasma membrane"), p(HGNC:SLC5A7)) - pmid:19732809 + pubmed:28901280 - bp(MESH:"Hot Temperature") association p(MESH:Proteins, pmod(HBP:"O-GlcNAcylation")) + bp(GO:"action potential initiation") association p(MESH:"Receptors, Nicotinic") - - - - - pmid:21131359 + pubmed:19126755 - a(CHEBI:"double-stranded DNA") association p(HGNC:MAPT) + act(complex(GO:"voltage-gated calcium channel complex")) increases bp(GO:"calcineurin-mediated signaling") - pmid:21131359 + pubmed:19126755 - a(CHEBI:"double-stranded DNA") isA complex(a(CHEBI:"double-stranded DNA"), p(HGNC:MAPT)) + act(complex(GO:"voltage-gated calcium channel complex")) decreases act(p(FPLX:CREB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) - pmid:8985176 + pubmed:19126755 - a(CHEBI:"transfer RNA") increases bp(GO:"neurofibrillary tangle assembly") + complex(GO:"voltage-gated calcium channel complex") association a(CHEBI:anandamide) - pmid:28173111 + pubmed:29428175 - r(MGI:Dnm1l) positiveCorrelation path(HBP:"mitochondrial dysfunction") + complex(GO:"voltage-gated calcium channel complex") increases a(CHEBI:"calcium(2+)", loc(MESH:Cytoplasm)) - pmid:28173111 + pubmed:19126755 - r(MGI:Dnm1l) negativeCorrelation act(complex(GO:mitochondrion)) + p(CONSO:"alpha-4-containing nAChR") increases tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:28173111 + pubmed:19126755 - r(MGI:Dnm1l) negativeCorrelation complex(GO:mitochondrion) + p(CONSO:"alpha-4-containing nAChR") association path(MESH:"Drug Tolerance") + + + + - pmid:28173111 + pubmed:19126755 - r(MGI:Dnm1l) positiveCorrelation p(MGI:Mapt, pmod(Ph)) + p(CONSO:"alpha-6-containing nAChR") increases tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:28173111 + pubmed:21787755 - r(MGI:Dnm1l) negativeCorrelation bp(MESH:"Mitochondrial Dynamics") + p(CONSO:"alpha-6-containing nAChR") association path(MESH:Pleasure) - pmid:28173111 + pubmed:21787755 - r(MGI:Dnm1l) negativeCorrelation act(complex(GO:"neuron to neuron synapse")) + p(CONSO:"alpha-6-containing nAChR") association path(MESH:Reward) - pmid:28173111 + pubmed:21787755 - r(MGI:Dnm1l) negativeCorrelation r(MGI:Syp) + p(CONSO:"alpha-6-containing nAChR") association path(MESH:Affect) - pmid:28173111 + pubmed:21787755 - r(MGI:Dnm1l) negativeCorrelation r(MGI:Dlg4) + p(CONSO:"alpha-6-containing nAChR") regulates tloc(a(CHEBI:"gamma-aminobutyric acid"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:28173111 + pubmed:21787755 - r(MGI:Dnm1l) negativeCorrelation r(MGI:Syn1) + p(CONSO:"alpha-6-containing nAChR") association path(MESH:"Tobacco Use Disorder") - pmid:28173111 + pubmed:21787755 - r(MGI:Dnm1l) negativeCorrelation r(MGI:Vamp1) + p(CONSO:"alpha-6-containing nAChR") regulates bp(GO:"neurotransmitter secretion") - pmid:28173111 + pubmed:19126755 - r(MGI:Dnm1l) negativeCorrelation r(HGNCGENEFAMILY:"Vesicle associated membrane proteins") + bp(GO:"neuronal action potential") increases tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:28173111 + pubmed:28445721 - r(MGI:Dnm1l) negativeCorrelation r(MGI:Synpo) + bp(GO:"neuronal action potential") regulates p(FPLX:CHRN) - pmid:28173111 + pubmed:19126755 - r(MGI:Dnm1l) negativeCorrelation r(MGI:Nrgn) + a(MESH:Neuroglia) increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:28173111 + pubmed:19126755 - r(MGI:Dnm1l) negativeCorrelation r(MGI:Gap43) + a(MESH:Keratinocytes) increases p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:28173111 + pubmed:28901280 - r(MGI:Dnm1l) positiveCorrelation r(MGI:Fis1) + a(MESH:Keratinocytes) increases complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) - pmid:28173111 + pubmed:28901280 - r(MGI:Dnm1l) positiveCorrelation r(MGI:Ppid) + a(MESH:Keratinocytes) increases p(HGNC:CHRNA9) - pmid:28173111 + pubmed:19126755 - r(MGI:Dnm1l) negativeCorrelation r(MGI:Mfn1) + a(MESH:"Cholinesterase Inhibitors") causesNoChange act(p(HGNC:CHRNA7)) - pmid:28173111 + pubmed:19293145 - r(MGI:Dnm1l) negativeCorrelation r(MGI:Mfn2) + act(a(MESH:"Cholinesterase Inhibitors")) decreases act(a(CHEBI:amyloid-beta)) - pmid:28173111 + pubmed:18986241 - r(MGI:Dnm1l) negativeCorrelation r(MGI:Opa1) + a(MESH:"Cholinesterase Inhibitors") decreases a(CHEBI:amyloid-beta) - pmid:28173111 + pubmed:19293145 - r(MGI:Dnm1l) negativeCorrelation r(MGI:Nrf1) + act(a(MESH:"Cholinesterase Inhibitors")) decreases act(a(CHEBI:"L-glutamate(2-)")) - pmid:28173111 + pubmed:26813123 - r(MGI:Dnm1l) negativeCorrelation r(MGI:Nfe2l2) + a(MESH:"Cholinesterase Inhibitors") increases a(CHEBI:acetylcholine) - pmid:28173111 + pubmed:26813123 - r(MGI:Dnm1l) negativeCorrelation r(MGI:Ppargc1a) + a(MESH:"Cholinesterase Inhibitors") increases bp(GO:cognition) - pmid:28173111 + pubmed:18986241 - r(MGI:Dnm1l) negativeCorrelation r(MGI:Tfam) + a(MESH:"Cholinesterase Inhibitors") decreases path(MESH:"Alzheimer Disease") - pmid:28173111 + pubmed:18986241 - act(complex(GO:mitochondrion)) negativeCorrelation r(MGI:Dnm1l) + a(MESH:"Cholinesterase Inhibitors") increases bp(MESH:Neuroprotection) - pmid:28173111 + pubmed:18986241 - complex(GO:mitochondrion) negativeCorrelation r(MGI:Dnm1l) + a(MESH:"Cholinesterase Inhibitors") association bp(GO:"amyloid-beta metabolic process") - pmid:28173111 + pubmed:18986241 - complex(GO:mitochondrion) association p(MGI:Nrf1) + a(MESH:"Cholinesterase Inhibitors") association path(MESH:"Sleep Initiation and Maintenance Disorders") - pmid:28173111 + pubmed:18986241 - complex(GO:mitochondrion) association p(MGI:Nfe2l2) + a(MESH:"Cholinesterase Inhibitors") association path(MESH:Diarrhea) - pmid:28173111 + pubmed:18986241 - complex(GO:mitochondrion) association p(MGI:Ppargc1a) + a(MESH:"Cholinesterase Inhibitors") association path(MESH:Nausea) - pmid:28173111 + pubmed:18986241 - complex(GO:mitochondrion) association p(MGI:Tfam) + a(MESH:"Cholinesterase Inhibitors") association path(MESH:Fatigue) - pmid:28173111 + pubmed:18986241 - bp(MESH:"Mitochondrial Dynamics") negativeCorrelation r(MGI:Dnm1l) + a(MESH:"Cholinesterase Inhibitors") association path(MESH:Anorexia) - pmid:28173111 + pubmed:19126755 - act(complex(GO:"neuron to neuron synapse")) negativeCorrelation r(MGI:Dnm1l) + a(CHEBI:physostigmine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:28173111 + pubmed:19126755 - act(complex(GO:"neuron to neuron synapse")) association p(MGI:Syp) + a(CHEBI:physostigmine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits", loc(MESH:"Neuromuscular Junction"))) - pmid:28173111 + pubmed:19126755 - act(complex(GO:"neuron to neuron synapse")) association p(MGI:Dlg4) + a(CHEBI:physostigmine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:28173111 + pubmed:18986241 - act(complex(GO:"neuron to neuron synapse")) association p(MGI:Syn1) + a(CHEBI:physostigmine) decreases path(MESH:"Alzheimer Disease") - pmid:28173111 + pubmed:19126755 - act(complex(GO:"neuron to neuron synapse")) association p(MGI:Vamp1) + a(CHEBI:"nicotinic antagonist") causesNoChange act(a(CHEBI:galanthamine)) - pmid:28173111 + pubmed:19126755 - act(complex(GO:"neuron to neuron synapse")) association p(HGNCGENEFAMILY:"Vesicle associated membrane proteins") + a(CHEBI:"nicotinic antagonist") causesNoChange act(a(CHEBI:physostigmine)) - pmid:28173111 + pubmed:19126755 - act(complex(GO:"neuron to neuron synapse")) association p(MGI:Synpo) + a(CHEBI:"nicotinic antagonist") causesNoChange a(CHEBI:codeine) - pmid:28173111 + pubmed:17009926 - act(complex(GO:"neuron to neuron synapse")) association p(MGI:Nrgn) + a(CHEBI:"nicotinic antagonist") decreases tloc(a(CHEBI:acetylcholine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:28173111 + pubmed:17009926 - act(complex(GO:"neuron to neuron synapse")) association p(MGI:Gap43) + a(CHEBI:"nicotinic antagonist") decreases tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:28173111 + pubmed:17009926 - r(MGI:Syp) negativeCorrelation r(MGI:Dnm1l) + a(CHEBI:"nicotinic antagonist") decreases tloc(a(CHEBI:noradrenaline), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:28173111 + pubmed:17009926 - p(MGI:Dnm1l) negativeCorrelation p(MGI:Syp) + a(CHEBI:"nicotinic antagonist") decreases tloc(a(CHEBI:serotonin), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:28173111 + pubmed:17009926 - p(MGI:Dnm1l) negativeCorrelation p(MGI:Dlg4) + a(CHEBI:"nicotinic antagonist") decreases tloc(a(CHEBI:"glutamate(2-)"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:28173111 + pubmed:17009926 - p(MGI:Dnm1l) negativeCorrelation p(MGI:Syn1) + a(CHEBI:"nicotinic antagonist") decreases tloc(a(CHEBI:"gamma-aminobutyric acid"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:28173111 + pubmed:17009926 - p(MGI:Dnm1l) negativeCorrelation p(MGI:Vamp1) + a(CHEBI:"nicotinic antagonist") decreases bp(GO:memory) - pmid:28173111 + pubmed:19126755 - p(MGI:Dnm1l) negativeCorrelation p(HGNCGENEFAMILY:"Vesicle associated membrane proteins") + a(CONSO:"FK1 antibody") decreases act(a(CHEBI:galanthamine)) - pmid:28173111 + pubmed:19126755 - p(MGI:Dnm1l) negativeCorrelation p(MGI:Synpo) + a(CONSO:"FK1 antibody") decreases act(a(CHEBI:physostigmine)) - pmid:28173111 + pubmed:19126755 - p(MGI:Dnm1l) negativeCorrelation p(MGI:Nrgn) + a(CONSO:"FK1 antibody") decreases a(CHEBI:codeine) - pmid:28173111 + pubmed:19126755 - p(MGI:Dnm1l) negativeCorrelation p(MGI:Gap43) + a(CHEBI:codeine) causesNoChange a(MESH:Cholinesterases) - pmid:28173111 + pubmed:19126755 - p(MGI:Dnm1l) positiveCorrelation p(MGI:Fis1) + a(CHEBI:codeine) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:28173111 + pubmed:19126755 - p(MGI:Dnm1l) association bp(GO:"mitochondrial fission") + path(MESH:"Sensory Gating") association g(HGNC:CHRNA7) - pmid:28173111 + pubmed:19126755 - p(MGI:Dnm1l) positiveCorrelation p(MGI:Ppid) + path(MESH:"Sensory Gating") association path(MESH:Schizophrenia) - pmid:28173111 + pubmed:19126755 - p(MGI:Dnm1l) negativeCorrelation p(MGI:Mfn1) + path(MESH:"Sensory Gating") association path(MESH:Schizophrenia) - pmid:28173111 + pubmed:19126755 - p(MGI:Dnm1l) negativeCorrelation p(MGI:Mfn2) + path(MESH:"Sensory Gating") association act(p(HGNC:CHRNA7)) - pmid:28173111 + pubmed:19126755 - p(MGI:Dnm1l) negativeCorrelation p(MGI:Opa1) + a(CHEBI:"kynurenic acid") negativeCorrelation act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:28173111 + pubmed:19126755 - p(MGI:Dnm1l) negativeCorrelation p(MGI:Nrf1) + a(CHEBI:"kynurenic acid") decreases act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) - pmid:28173111 + pubmed:19126755 - p(MGI:Dnm1l) negativeCorrelation p(MGI:Nfe2l2) + a(CHEBI:"kynurenic acid") decreases act(p(HGNC:CHRNA7)) - pmid:28173111 + pubmed:19126755 - p(MGI:Dnm1l) negativeCorrelation p(MGI:Ppargc1a) + a(CHEBI:"kynurenic acid") regulates act(p(HGNC:CHRNA7)) - pmid:28173111 + pubmed:19126755 - p(MGI:Dnm1l) negativeCorrelation p(MGI:Tfam) + a(CHEBI:"kynurenic acid") regulates act(p(HGNC:CHRNA7)) - pmid:28173111 + pubmed:19126755 - r(MGI:Dlg4) negativeCorrelation r(MGI:Dnm1l) + a(CHEBI:"kynurenic acid") decreases act(p(HGNC:CHRNA7)) - pmid:28173111 + pubmed:19126755 - r(MGI:Syn1) negativeCorrelation r(MGI:Dnm1l) + a(CHEBI:"kynurenic acid") decreases act(p(HGNC:CHRNA7)) - pmid:28173111 + pubmed:19126755 - p(MGI:Syn1) negativeCorrelation p(MGI:Dnm1l) + a(CHEBI:"kynurenic acid") decreases act(p(MGI:Chrna7, loc(MESH:Interneurons))) - pmid:28173111 + pubmed:19126755 - p(MGI:Syn1) association act(complex(GO:"neuron to neuron synapse")) + a(CHEBI:"kynurenic acid") regulates bp(MESH:"Neuronal Plasticity") - pmid:28173111 + pubmed:19126755 - r(MGI:Vamp1) negativeCorrelation r(MGI:Dnm1l) + a(CHEBI:"kynurenic acid") regulates bp(GO:"synaptic transmission, cholinergic") - pmid:28173111 + pubmed:19126755 - p(MGI:Vamp1) negativeCorrelation p(MGI:Dnm1l) + a(CHEBI:"kynurenic acid") regulates path(MESH:"Cell Survival") - pmid:28173111 + pubmed:19126755 - p(MGI:Vamp1) association act(complex(GO:"neuron to neuron synapse")) + a(CHEBI:"kynurenic acid") decreases a(CHEBI:dopamine, loc(GO:"extracellular region")) - pmid:28173111 + pubmed:19126755 - r(HGNCGENEFAMILY:"Vesicle associated membrane proteins") negativeCorrelation r(MGI:Dnm1l) + a(CHEBI:L-kynurenine) increases a(CHEBI:"kynurenic acid") - pmid:28173111 + pubmed:19126755 - p(HGNCGENEFAMILY:"Vesicle associated membrane proteins") negativeCorrelation p(MGI:Dnm1l) + a(MESH:Probenecid) decreases a(CHEBI:"kynurenic acid") - pmid:28173111 + pubmed:19126755 - p(HGNCGENEFAMILY:"Vesicle associated membrane proteins") association act(complex(GO:"neuron to neuron synapse")) + act(p(HGNC:AADAT), ma(go:0003824 ! "catalytic activity")) increases a(CHEBI:"kynurenic acid") - pmid:28173111 + pubmed:19126755 - r(MGI:Synpo) negativeCorrelation r(MGI:Dnm1l) + a(CHEBI:kynurenine) increases a(CHEBI:"kynurenic acid") - pmid:28173111 + pubmed:19126755 - p(MGI:Synpo) negativeCorrelation p(MGI:Dnm1l) + a(CHEBI:kynurenine) increases a(CHEBI:3-hydroxykynurenine) - pmid:28173111 + pubmed:19126755 - p(MGI:Synpo) association act(complex(GO:"neuron to neuron synapse")) + a(CHEBI:kynurenine) increases a(CHEBI:"quinolinic acid") - pmid:28173111 + pubmed:19165623 - r(MGI:Nrgn) negativeCorrelation r(MGI:Dnm1l) + a(CHEBI:"quinolinic acid") increases a(CHEBI:"nicotinic acid") - pmid:28173111 + pubmed:19623258 - p(MGI:Nrgn) negativeCorrelation p(MGI:Dnm1l) + a(CHEBI:"quinolinic acid") association p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:28173111 + pubmed:19623258 - p(MGI:Nrgn) association act(complex(GO:"neuron to neuron synapse")) + a(CHEBI:"quinolinic acid") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) - pmid:28173111 + pubmed:19623258 - r(MGI:Gap43) negativeCorrelation r(MGI:Dnm1l) + a(CHEBI:"quinolinic acid") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) - pmid:28173111 + pubmed:19623258 - p(MGI:Gap43) negativeCorrelation p(MGI:Dnm1l) + a(CHEBI:"quinolinic acid") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) - pmid:28173111 + pubmed:19623258 - p(MGI:Gap43) association act(complex(GO:"neuron to neuron synapse")) + a(CHEBI:"quinolinic acid") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) - pmid:28173111 + pubmed:19623258 - r(MGI:Fis1) positiveCorrelation r(MGI:Dnm1l) + a(CHEBI:"quinolinic acid") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) - pmid:28173111 + pubmed:19623258 - p(MGI:Fis1) positiveCorrelation p(MGI:Dnm1l) + a(CHEBI:"quinolinic acid") decreases act(p(FPLX:PPP2)) - pmid:28173111 + pubmed:19623258 - p(MGI:Fis1) association bp(GO:"mitochondrial fission") + a(CHEBI:"quinolinic acid") decreases act(p(FPLX:PPP1)) - pmid:28173111 + pubmed:19623258 - bp(GO:"mitochondrial fission") association p(MGI:Fis1) + a(CHEBI:"quinolinic acid") increases act(complex(GO:"NMDA selective glutamate receptor complex")) - pmid:28173111 + pubmed:19623258 - bp(GO:"mitochondrial fission") association p(MGI:Dnm1l) + a(CHEBI:"quinolinic acid") increases r(HGNC:BRCA1) - pmid:28173111 + pubmed:19623258 - r(MGI:Ppid) positiveCorrelation r(MGI:Dnm1l) + a(CHEBI:"quinolinic acid") increases r(HGNC:MYC) - pmid:28173111 + pubmed:19623258 - p(MGI:Ppid) positiveCorrelation p(MGI:Dnm1l) + a(CHEBI:"quinolinic acid") increases r(HGNC:WNT1) - pmid:28173111 + pubmed:19623258 - p(MGI:Ppid) association complex(GO:"mitochondrial matrix") + a(CHEBI:"quinolinic acid") increases r(HGNC:CCN4) - pmid:28173111 + pubmed:19623258 - complex(GO:"mitochondrial matrix") association p(MGI:Ppid) + a(CHEBI:"quinolinic acid") increases r(HGNC:CDK5) - pmid:28173111 + pubmed:19623258 - r(MGI:Mfn1) negativeCorrelation r(MGI:Dnm1l) + a(CHEBI:"quinolinic acid") increases r(HGNC:IL1A) - pmid:28173111 + pubmed:19623258 - p(MGI:Mfn1) negativeCorrelation p(MGI:Dnm1l) + a(CHEBI:"quinolinic acid") increases r(HGNC:NOS2) - pmid:28173111 + pubmed:19623258 - p(MGI:Mfn1) association bp(GO:"mitochondrial fusion") + a(CHEBI:"quinolinic acid") increases r(HGNC:CEBPB) - pmid:28173111 + pubmed:19623258 - r(MGI:Mfn2) negativeCorrelation r(MGI:Dnm1l) + a(CHEBI:"quinolinic acid") increases r(HGNC:CSF2) - pmid:28173111 + pubmed:19623258 - p(MGI:Mfn2) negativeCorrelation p(MGI:Dnm1l) + a(CHEBI:"quinolinic acid") increases r(HGNC:LEP) - pmid:28173111 + pubmed:19126755 - p(MGI:Mfn2) association bp(GO:"mitochondrial fusion") + act(p(MGI:Chrna7, loc(MESH:Interneurons))) increases act(a(MESH:"GABAergic Neurons")) - pmid:28173111 + pubmed:19126755 - r(MGI:Opa1) negativeCorrelation r(MGI:Dnm1l) + p(MGI:Chrna7) negativeCorrelation path(MESH:Aging) - pmid:28173111 + pubmed:19293145 - p(MGI:Opa1) negativeCorrelation p(MGI:Dnm1l) + p(MGI:Chrna7) increases bp(MESH:"Neuronal Outgrowth") + + + + + + - pmid:28173111 + pubmed:25514383 - p(MGI:Opa1) association bp(GO:"mitochondrial fusion") + p(MGI:Chrna7) decreases path(MESH:"Spatial Memory") - pmid:28173111 + pubmed:25881725 - bp(GO:"mitochondrial fusion") association p(MGI:Mfn1) + act(p(MGI:Chrna7)) increases path(MESH:"Spatial Memory") - pmid:28173111 + pubmed:25514383 - bp(GO:"mitochondrial fusion") association p(MGI:Mfn2) + p(MGI:Chrna7) decreases p(MGI:Syp) - pmid:28173111 + pubmed:25514383 - bp(GO:"mitochondrial fusion") association p(MGI:Opa1) + p(MGI:Chrna7) decreases p(MGI:Map2) - pmid:28173111 + pubmed:25514383 - r(MGI:Nrf1) negativeCorrelation r(MGI:Dnm1l) + p(MGI:Chrna7) increases p(MGI:Map2) - pmid:28173111 + pubmed:25514383 - p(MGI:Nrf1) negativeCorrelation p(MGI:Dnm1l) + p(MGI:Chrna7) increases a(CHEBI:amyloid-beta) - pmid:28173111 + pubmed:25514383 - p(MGI:Nrf1) association complex(GO:mitochondrion) + p(MGI:Chrna7) decreases a(CHEBI:amyloid-beta) - pmid:28173111 + pubmed:25514383 - r(MGI:Nfe2l2) negativeCorrelation r(MGI:Dnm1l) + p(MGI:Chrna7) increases bp(GO:cognition) - pmid:28173111 + pubmed:25514383 - p(MGI:Nfe2l2) negativeCorrelation p(MGI:Dnm1l) + p(MGI:Chrna7) decreases path(MESH:"Cognition Disorders") - pmid:28173111 + pubmed:25514383 - p(MGI:Nfe2l2) association complex(GO:mitochondrion) + p(MGI:Chrna7) increases path(MESH:"Plaque, Amyloid") + + - pmid:29121589 + pubmed:27522251 - p(MGI:Nfe2l2) decreases bp(GO:"inflammatory response") + p(MGI:Chrna7) decreases path(MESH:"Memory Disorders") - pmid:28173111 + pubmed:27522251 - r(MGI:Ppargc1a) negativeCorrelation r(MGI:Dnm1l) + p(MGI:Chrna7) decreases path(MESH:"Memory Disorders") - pmid:28173111 + pubmed:27522251 - p(MGI:Ppargc1a) negativeCorrelation p(MGI:Dnm1l) + p(MGI:Chrna7) decreases path(MESH:"Cognitive Dysfunction") - pmid:28173111 + pubmed:27522251 - p(MGI:Ppargc1a) association complex(GO:mitochondrion) + p(MGI:Chrna7) association bp(GO:aging) - pmid:25987199 + pubmed:27522251 - act(p(MGI:Ppargc1a)) positiveCorrelation act(a(GO:mitochondrion)) + p(MGI:Chrna7) increases a(CONSO:CONSO00022) + + - pmid:28173111 + pubmed:25881725 - r(MGI:Tfam) negativeCorrelation r(MGI:Dnm1l) + act(p(MGI:Chrna7)) increases bp(GO:learning) - pmid:28173111 + pubmed:25881725 - p(MGI:Tfam) negativeCorrelation p(MGI:Dnm1l) + p(MGI:Chrna7) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:28173111 + pubmed:28901280 - p(MGI:Tfam) association complex(GO:mitochondrion) + p(MGI:Chrna7) association act(a(MESH:Epithelium)) - pmid:25974414 + pubmed:21482353 - p(HGNC:MAPT, var("p.Asp13*")) partOf a(GO:"neurofibrillary tangle") + a(MESH:"GABAergic Neurons") positiveCorrelation p(CONSO:"alpha-4 beta-2 nAChR") - pmid:25974414 + pubmed:18986241 - p(HGNC:MAPT, var("p.Asp13*")) positiveCorrelation path(MESH:"Alzheimer Disease") + a(MESH:"GABAergic Neurons") association path(MESH:"Cholinergic Neurons") - pmid:25974414 + pubmed:30027901 - p(HGNC:MAPT, var("p.Asp13*")) isA p(HGNC:MAPT) + a(MESH:"GABAergic Neurons") increases p(HGNC:GAD1) - pmid:25974414 + pubmed:30027901 - p(HGNC:MAPT, var("p.Asp25*")) partOf a(GO:"neurofibrillary tangle") + a(MESH:"GABAergic Neurons") increases p(HGNC:TAC1) - pmid:25974414 + pubmed:30027901 - p(HGNC:MAPT, var("p.Asp25*")) positiveCorrelation path(MESH:"Alzheimer Disease") + a(MESH:"GABAergic Neurons") increases p(MESH:Enkephalins) - pmid:25974414 + pubmed:30027901 - p(HGNC:MAPT, var("p.Asp368*")) partOf a(GO:"neurofibrillary tangle") + a(MESH:"GABAergic Neurons") increases a(CHEBI:calcineurin) - pmid:25974414 + pubmed:30027901 - p(HGNC:MAPT, var("p.Asp368*")) positiveCorrelation path(MESH:"Alzheimer Disease") + a(MESH:"GABAergic Neurons") increases p(HGNC:CALB1) - pmid:25974414 + pubmed:30027901 - p(HGNC:MAPT, var("p.Asp421*")) partOf a(GO:"neurofibrillary tangle") + a(MESH:"GABAergic Neurons") increases a(CHEBI:"Adenosine 5'-phosphate disodium") - pmid:25974414 + pubmed:30027901 - p(HGNC:MAPT, var("p.Asp421*")) positiveCorrelation path(MESH:"Alzheimer Disease") + a(MESH:"GABAergic Neurons") increases p(HGNCGENEFAMILY:"Dopamine receptors") - pmid:26671985 + pubmed:30027901 - p(HGNC:MAPT, var("p.Asp421*")) biomarkerFor path(MESH:"Chronic Traumatic Encephalopathy") + deg(a(MESH:"GABAergic Neurons")) prognosticBiomarkerFor path(MESH:"Huntington Disease") - pmid:26671985 + pubmed:19126755 - p(HGNC:MAPT, var("p.Asp421*")) association path(HBP:neurotoxicity) + a(MESH:"Mossy Fibers, Hippocampal") increases a(CHEBI:"glutamate(2-)", loc(MESH:"Pyramidal Cells")) - pmid:25974414 + pubmed:19126755 - p(HGNC:MAPT, var("p.Ala2*")) isA p(HGNC:MAPT) + a(MESH:"7-chlorothiokynurenic acid") causesNoChange a(CHEBI:dopamine, loc(GO:"extracellular region")) + + + + + + - pmid:25974414 + pubmed:28901280 - p(HGNC:MAPT, pmod(HBP:polyamination, Gln, 6)) isA p(HGNC:MAPT) + a(MESH:Acetylcholine) association bp(GO:"cell-cell signaling") - pmid:25974414 + pubmed:28901280 - p(HGNC:MAPT, var("p.Ala103*")) isA p(HGNC:MAPT) + a(MESH:Acetylcholine) association bp(GO:"cell proliferation") - pmid:25974414 + pubmed:28901280 - p(HGNC:MAPT, var("p.Gln124*")) isA p(HGNC:MAPT) + a(MESH:Acetylcholine) association bp(GO:"cell adhesion") - pmid:25974414 + pubmed:28901280 - p(HGNC:MAPT, var("p.Gln124*")) increases p(FPLX:Tubulin, pmod(Ac)) + a(MESH:Acetylcholine) association bp(MESH:"Cell Movement") - pmid:25974414 + pubmed:28901280 - p(HGNC:MAPT, var("p.Gln124*")) increases p(INTERPRO:"Alpha tubulin", pmod(HBP:detyrosination)) + a(MESH:Acetylcholine) association bp(GO:"secretion by cell") - pmid:25974414 + pubmed:28901280 - p(HGNC:MAPT, var("p.Gln124*")) positiveCorrelation act(p(HGNC:VASH1)) + a(MESH:Acetylcholine) association bp(MESH:"Cell Survival") - pmid:25974414 + pubmed:28901280 - p(HGNC:MAPT, var("p.Gln124*")) positiveCorrelation act(p(HGNC:VASH2)) + a(MESH:Acetylcholine) association bp(MESH:Apoptosis) - pmid:25974414 + pubmed:28901280 - p(HGNC:MAPT, var("p.Met127*")) isA p(HGNC:MAPT) + a(MESH:Acetylcholine) association bp(MESH:"Autocrine Communication") - pmid:25974414 + pubmed:28901280 - p(HGNC:MAPT, var("p.Pro172*")) isA p(HGNC:MAPT) + a(MESH:Acetylcholine) association bp(MESH:"Paracrine Communication") - pmid:25974414 + pubmed:28901280 - p(HGNC:MAPT, var("p.Lys174*")) isA p(HGNC:MAPT) + a(MESH:Acetylcholine) decreases path(MESH:Inflammation) - pmid:25974414 + pubmed:28901280 - p(HGNC:MAPT, var("p.Lys224*")) isA p(HGNC:MAPT) + a(MESH:Acetylcholine) increases path(MESH:Neoplasms) - pmid:25974414 + pubmed:28901280 - p(HGNC:MAPT, var("p.Ser238*")) isA p(HGNC:MAPT) + a(MESH:Acetylcholine) increases act(complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9))) - pmid:25974414 + pubmed:28901280 - p(HGNC:MAPT, var("p.Lys240*")) isA p(HGNC:MAPT) + a(MESH:Acetylcholine) increases act(p(HGNC:CHRNA9)) - pmid:25974414 + pubmed:19126755 - p(HGNC:MAPT, var("p.Lys259*")) isA p(HGNC:MAPT) + a(CHEBI:anandamide) association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:25974414 + pubmed:19126755 - p(HGNC:MAPT, var("p.Gly261*")) isA p(HGNC:MAPT) + a(CHEBI:anandamide) association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:25974414 + pubmed:19126755 - p(HGNC:MAPT, var("p.Lys280*")) isA p(HGNC:MAPT) + a(CHEBI:anandamide) association p(HGNC:CNR1) - pmid:25974414 + pubmed:19126755 - p(HGNC:MAPT, var("p.Val306*")) isA p(HGNC:MAPT) + a(CHEBI:anandamide) association p(HGNC:CNR2) - pmid:25974414 + pubmed:19126755 - p(HGNC:MAPT, var("p.Ile308*")) isA p(HGNC:MAPT) + a(CHEBI:anandamide) association complex(GO:"voltage-gated calcium channel complex") - pmid:25974414 + pubmed:19126755 - p(HGNC:MAPT, var("p.Val309*")) isA p(HGNC:MAPT) + a(CHEBI:anandamide) association p(HGNCGENEFAMILY:"Potassium voltage-gated channels") - pmid:25974414 + pubmed:19126755 - p(HGNC:MAPT, var("p.Lys311*")) isA p(HGNC:MAPT) + a(CHEBI:anandamide) association a(MESH:"Receptors, Serotonin") - pmid:25974414 + pubmed:19126755 - p(HGNC:MAPT, var("p.Lys331*")) isA p(HGNC:MAPT) + a(CHEBI:anandamide) association p(HGNCGENEFAMILY:"Glutamate ionotropic receptor kainate type subunits") - pmid:25974414 + pubmed:19126755 - p(HGNC:MAPT, var("p.Lys395*")) isA p(HGNC:MAPT) + a(CHEBI:anandamide) decreases act(p(HGNC:CHRNA7)) - pmid:25974414 + pubmed:19126755 - p(HGNC:MAPT, var("p.Met11*")) isA p(HGNC:MAPT) + a(CHEBI:anandamide) decreases act(p(CONSO:"alpha-4 beta-2 nAChR")) - pmid:25974414 + pubmed:19126755 - p(HGNC:MAPT, var("p.Glu12*")) isA p(HGNC:MAPT) + a(CHEBI:anandamide) regulates bp(GO:"chemical synaptic transmission, postsynaptic") - - - pmid:28002468 + pubmed:19126755 - p(FPLX:Tubulin) decreases p(HGNC:MAP2, pmod(Ac)) + p(CONSO:gamma-secretase) increases a(CHEBI:"amyloid-beta polypeptide 42") @@ -153398,1512 +154975,1461 @@

Statements

- pmid:25974414 + pubmed:19293145 - act(p(HGNC:VASH1)) positiveCorrelation p(HGNC:MAPT, var("p.Gln124*")) + complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7)) decreases act(a(MESH:Bungarotoxins)) - pmid:25974414 + pubmed:17009926 - act(p(HGNC:VASH1)) increases p(INTERPRO:"Alpha tubulin", pmod(HBP:detyrosination)) + complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7)) association path(MESH:"Alzheimer Disease") - pmid:25974414 + pubmed:25514383 - act(p(HGNC:VASH2)) positiveCorrelation p(HGNC:MAPT, var("p.Gln124*")) + complex(a(CHEBI:"amyloid-beta polypeptide 42"), p(HGNC:CHRNA7)) association path(MESH:"Plaque, Amyloid") - pmid:25974414 + pubmed:19126755 - act(p(HGNC:VASH2)) increases p(INTERPRO:"Alpha tubulin", pmod(HBP:detyrosination)) + p(HGNC:CNR2) association a(CHEBI:anandamide) - pmid:25974414 + pubmed:19126755 - act(p(HGNC:TAOK2), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + a(MESH:"Receptors, Serotonin") association a(CHEBI:anandamide) - pmid:16566606 + pubmed:19126755 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) decreases bp(GO:"tubulin complex assembly") + a(CHEBI:bupropion) decreases act(p(HGNC:CHRNA7)) - pmid:16566606 + pubmed:19126755 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) association p(HGNC:MAPT, pmod(HBP:misfolded)) + a(CHEBI:bupropion) decreases act(p(CONSO:"alpha-4 beta-2 nAChR")) - pmid:22057784 + pubmed:19126755 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") + a(CHEBI:bupropion) decreases act(p(CONSO:"alpha-3 beta-4 nAChR")) - pmid:22057784 + pubmed:19126755 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) positiveCorrelation path(HBP:"Corticobasal Degeneration") + a(CHEBI:bupropion) association path(MESH:"Smoking Cessation") - pmid:22057784 + pubmed:28391535 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) partOf a(MESH:"Neuropil Threads") + a(CHEBI:bupropion) association path(MESH:"Smoking Cessation") - pmid:17050703 + pubmed:28391535 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) isA p(HGNC:MAPT, pmod(HBP:nitration)) + a(CHEBI:bupropion) increases act(a(MESH:"Central Nervous System")) - pmid:16566606 + pubmed:28391535 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) decreases bp(GO:"microtubule polymerization") + a(CHEBI:bupropion) decreases path(MESH:Depression) - pmid:16566606 + pubmed:28391535 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) positiveCorrelation a(HBP:"paired helical filaments") + a(CHEBI:bupropion) decreases act(a(CHEBI:nicotine)) - pmid:16566606 + pubmed:19126755 - p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 197)) negativeCorrelation act(p(HGNC:MAPT)) + a(MESH:"N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline") decreases act(p(HGNC:CHRNA7)) - pmid:24869773 + pubmed:19126755 - p(HGNC:MAPT, pmod(Me, Lys, 311)) association path(MESH:"Alzheimer Disease") + a(MESH:"N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline") decreases act(p(CONSO:"alpha-4 beta-2 nAChR")) - pmid:24869773 + pubmed:19126755 - p(HGNC:MAPT, pmod(Me, Lys, 311)) association p(HBP:"Tau aggregates") + a(MESH:"N-(1,2,3,4-tetrahydro-1-naphthyl)-4-nitroaniline") decreases act(p(CONSO:"alpha-3 beta-4 nAChR")) - pmid:24869773 + pubmed:19126755 - p(HGNC:MAPT, pmod(Me, Lys, 259)) regulates complex(a(GO:microtubule), p(HGNC:MAPT)) + path(MESH:"Smoking Cessation") association a(CHEBI:bupropion) - pmid:24869773 + pubmed:28391535 - p(HGNC:MAPT, pmod(Me, Lys, 259)) isA p(HGNC:MAPT, pmod(Me, Lys)) + path(MESH:"Smoking Cessation") association a(CHEBI:bupropion) - pmid:24869773 + pubmed:28391535 - p(HGNC:MAPT, pmod(Me, Lys, 290)) regulates complex(a(GO:microtubule), p(HGNC:MAPT)) + path(MESH:"Smoking Cessation") increases path(MESH:"Irritable Mood") - pmid:24869773 + pubmed:28391535 - p(HGNC:MAPT, pmod(Me, Lys, 290)) isA p(HGNC:MAPT, pmod(Me, Lys)) + path(MESH:"Smoking Cessation") increases path(MESH:Anger) - pmid:22033876 + pubmed:28391535 - p(HGNC:MAPT, pmod(Me, Lys, 290)) partOf p(HBP:"tubulin-binding repeat 2") + path(MESH:"Smoking Cessation") increases path(MESH:"Stress, Psychological") - pmid:24869773 + pubmed:28391535 - p(HGNC:MAPT, pmod(Me, Lys, 353)) regulates complex(a(GO:microtubule), p(HGNC:MAPT)) + path(MESH:"Smoking Cessation") increases path(MESH:Anxiety) - pmid:24869773 + pubmed:28391535 - p(HGNC:MAPT, pmod(Me, Lys, 353)) isA p(HGNC:MAPT, pmod(Me, Lys)) + path(MESH:"Smoking Cessation") increases path(MESH:"Sleep Wake Disorders") - pmid:24869773 + pubmed:28391535 - p(HGNC:MAPT, pmod(Me, Lys, 24)) association p(HGNC:MAPT) + path(MESH:"Smoking Cessation") increases path(MESH:Depression) - pmid:24869773 + pubmed:28391535 - p(HGNC:MAPT, pmod(Me, Lys, 24)) isA p(HGNC:MAPT, pmod(Me, Lys)) + path(MESH:"Smoking Cessation") increases path(MESH:Craving) - pmid:24869773 + pubmed:28391535 - p(HGNC:MAPT, pmod(Me, Lys, 44)) association p(HGNC:MAPT) + path(MESH:"Smoking Cessation") decreases bp(GO:cognition) - pmid:24869773 + pubmed:28391535 - p(HGNC:MAPT, pmod(Me, Lys, 44)) isA p(HGNC:MAPT, pmod(Me, Lys)) + path(MESH:"Smoking Cessation") decreases path(MESH:Attention) - pmid:24869773 + pubmed:28391535 - p(HGNC:MAPT, pmod(Me, Lys, 67)) association p(HGNC:MAPT) + path(MESH:"Smoking Cessation") increases path(MESH:Appetite) - pmid:24869773 + pubmed:28391535 - p(HGNC:MAPT, pmod(Me, Lys, 67)) isA p(HGNC:MAPT, pmod(Me, Lys)) + path(MESH:"Smoking Cessation") association a(CHEBI:varenicline) - pmid:24869773 + pubmed:19721446 - p(HGNC:MAPT, pmod(Me, Lys, 190)) association p(HGNC:MAPT) + act(p(FPLX:"CAMK2_complex")) increases act(a(CHEBI:nicotine)) - pmid:24869773 + pubmed:23001711 - p(HGNC:MAPT, pmod(Me, Lys, 190)) isA p(HGNC:MAPT, pmod(Me, Lys)) + p(FPLX:"CAMK2_complex") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) - pmid:22033876 + pubmed:19126755 - p(HGNC:MAPT, pmod(Me, Lys, 163)) partOf p(HBP:"proline-rich domain") + path(MESH:"Tobacco Use Disorder") association act(p(HGNC:MAPK1)) - pmid:22033876 + pubmed:19126755 - p(HBP:"proline-rich domain") regulates complex(p(FPLX:Actin), p(HGNC:MAPT)) + path(MESH:"Tobacco Use Disorder") association act(p(FPLX:CREB)) - pmid:22033876 + pubmed:19126755 - p(HBP:"proline-rich domain") regulates complex(p(HGNC:MAPT), p(INTERPRO:"SH3 domain")) + path(MESH:"Tobacco Use Disorder") decreases path(MESH:"Wound Healing") - pmid:22033876 + pubmed:19126755 - p(HBP:"proline-rich domain") regulates complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:"Src family tyrosine kinases")) + path(MESH:"Tobacco Use Disorder") decreases path(MESH:"Wound Healing") - pmid:22033876 + pubmed:19126755 - p(HBP:"proline-rich domain") regulates complex(p(HGNC:MAPT), p(HGNC:PLCG1)) + path(MESH:"Tobacco Use Disorder") association path(MESH:Infection) - pmid:22033876 + pubmed:19126755 - p(HGNC:MAPT, pmod(Me, Lys, 174)) partOf p(HBP:"proline-rich domain") + path(MESH:"Tobacco Use Disorder") association path(MESH:"Skin Aging") - pmid:22033876 + pubmed:19126755 - p(HGNC:MAPT, pmod(Me, Lys, 180)) partOf p(HBP:"proline-rich domain") + path(MESH:"Tobacco Use Disorder") increases path(MESH:"Skin Aging") - - - - - - - - - - - - - pmid:22033876 + pubmed:19126755 - p(HGNC:MAPT, pmod(Me, Lys, 254)) partOf p(HBP:"tubulin-binding repeat 1") + path(MESH:"Tobacco Use Disorder") association path(MESH:Neoplasms) - pmid:22033876 + pubmed:19126755 - p(HGNC:MAPT, pmod(Me, Lys, 267)) partOf p(HBP:"tubulin-binding repeat 1") + path(MESH:"Tobacco Use Disorder") decreases path(MESH:"Colitis, Ulcerative") - - - pmid:23943618 + pubmed:19126755 - complex(p(FPLX:PPP2), p(HGNC:MAPT)) positiveCorrelation act(p(FPLX:PPP2)) + path(MESH:"Tobacco Use Disorder") increases path(MESH:"Crohn Disease") - - - pmid:23943618 + pubmed:19126755 - complex(p(FPLX:PPP2), p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(Ph)) + path(MESH:"Tobacco Use Disorder") association path(MESH:"Insulin Resistance") - pmid:22764226 + pubmed:19126755 - act(a(CHEBI:"L-dopa")) decreases p(HGNC:PPP2CA, pmod(Me)) + path(MESH:"Tobacco Use Disorder") negativeCorrelation path(MESH:"Parkinson Disease") - pmid:22764226 + pubmed:22530628 - act(a(CHEBI:"L-dopa")) decreases p(HGNC:PPP2CA, pmod(Me)) + path(MESH:"Tobacco Use Disorder") association p(HGNC:CHRNA7) - pmid:22764226 + pubmed:29428175 - act(a(CHEBI:"L-dopa")) decreases p(HGNC:PPP2CA, pmod(Me)) + path(MESH:"Tobacco Use Disorder") positiveCorrelation g(HGNC:RHOA, var("?")) - pmid:22764226 + pubmed:28445721 - act(a(CHEBI:"L-dopa")) increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + path(MESH:"Tobacco Use Disorder") association p(FPLX:CHRN) - pmid:22764226 + pubmed:21482353 - act(a(CHEBI:"L-dopa")) increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + path(MESH:"Tobacco Use Disorder") association act(p(FPLX:CHRN)) - pmid:22764226 + pubmed:21482353 - act(a(CHEBI:"L-dopa")) increases p(HGNC:MAPT, pmod(Ph)) + path(MESH:"Tobacco Use Disorder") positiveCorrelation p(HGNC:CHRNA5, var("?")) - pmid:22764226 + pubmed:21482353 - act(a(CHEBI:"L-dopa")) increases a(CHEBI:homocysteine) + path(MESH:"Tobacco Use Disorder") positiveCorrelation p(HGNC:CHRNA5, var("?")) - pmid:22764226 + pubmed:21482353 - act(a(CHEBI:"L-dopa")) decreases p(MGI:Ppp2ca, pmod(Me)) + path(MESH:"Tobacco Use Disorder") positiveCorrelation path(MESH:Schizophrenia) - pmid:22764226 + pubmed:21482353 - p(MGI:Ppp2ca, pmod(Me)) negativeCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396)) + path(MESH:"Tobacco Use Disorder") positiveCorrelation p(HGNC:CHRNA3, var("?")) - pmid:22764226 + pubmed:21482353 - p(MGI:Ppp2ca, pmod(Me)) negativeCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 404)) + path(MESH:"Tobacco Use Disorder") positiveCorrelation p(HGNC:CHRNB4, var("?")) - - - pmid:25143394 + pubmed:21482353 - p(MGI:Ppp2ca) negativeCorrelation p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) + path(MESH:"Tobacco Use Disorder") increases act(p(CONSO:"alpha-4 beta-2 nAChR")) - pmid:25681682 + pubmed:21787755 - bp(MESH:"Body Mass Index") negativeCorrelation p(HGNC:AGER) + path(MESH:"Tobacco Use Disorder") association complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) - - - - - pmid:24183963 + pubmed:21787755 - composite(a(CHEBI:glucose), a(PUBCHEM:16132389)) increases p(HGNC:MAPT, pmod(Ph, Thr, 205)) + path(MESH:"Tobacco Use Disorder") association composite(r(HGNC:CHRNA4), r(HGNC:CHRNB4)) - pmid:24183963 + pubmed:21787755 - composite(a(CHEBI:glucose), a(PUBCHEM:16132389)) decreases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) + path(MESH:"Tobacco Use Disorder") association p(CONSO:"alpha-6-containing nAChR") - pmid:24183963 + pubmed:28901280 - p(HGNC:GLP1R) decreases p(HGNC:MAPT, pmod(Ph, Thr, 205)) + path(MESH:"Tobacco Use Disorder") association g(DBSNP:rs1051730) - pmid:24183963 + pubmed:19126755 - p(HGNC:GLP1R) increases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) + a(MESH:Skin) association act(a(CHEBI:nicotine)) - pmid:25987199 + pubmed:29626319 - p(HGNC:GLP1R) decreases bp(MESH:"Oxidative Stress") + a(MESH:Skin) decreases a(CHEBI:amyloid-beta) - pmid:25987199 + pubmed:29626319 - p(HGNC:GLP1R) increases act(a(GO:mitochondrion)) + a(MESH:Skin) decreases a(CHEBI:"amyloid-beta polypeptide 40") - pmid:25987199 + pubmed:29626319 - p(HGNC:GLP1R) decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + a(MESH:Skin) causesNoChange a(CHEBI:"amyloid-beta polypeptide 42") - pmid:24183963 + pubmed:19126755 - a(CHEBI:"exendin-4") decreases p(HGNC:MAPT, pmod(Ph, Thr, 205)) + path(MESH:"Skin Aging") association path(MESH:"Tobacco Use Disorder") - pmid:24183963 + pubmed:22807490 - a(CHEBI:"exendin-4") increases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) + path(MESH:"Colitis, Ulcerative") association path(MESH:Smoking) - - - - - pmid:23531502 + pubmed:23746257 - complex(a(CHEBI:cinnamaldehydes), p(HGNC:MAPT)) decreases a(HBP:"Tau aggregates") + bp(GO:"cell cycle") association p(FPLX:HSP90) - pmid:23531502 + pubmed:30126037 - a(CHEBI:cinnamaldehydes) decreases act(a(CHEBI:"hydrogen peroxide")) + bp(GO:"cell cycle") association bp(GO:"cellular senescence") - pmid:23531502 + pubmed:27190210 - a(CHEBI:cinnamaldehydes) decreases a(HBP:"Tau aggregates") + bp(MESH:Apoptosis) association p(HGNC:CHRNA7) - - - - - pmid:23531502 + pubmed:28901280 - complex(a(CHEBI:"(-)-epicatechin"), p(HGNC:MAPT)) decreases a(HBP:"Tau aggregates") + bp(MESH:Apoptosis) association a(MESH:Acetylcholine) - pmid:23531502 + pubmed:21722302 - a(CHEBI:"(-)-epicatechin") decreases act(a(CHEBI:"hydrogen peroxide")) + bp(MESH:Apoptosis) association p(HGNC:BAX) - pmid:23531502 + pubmed:21722302 - a(CHEBI:"(-)-epicatechin") decreases a(HBP:"Tau aggregates") + bp(MESH:Apoptosis) association p(HGNC:BAK1) - pmid:23531502 + pubmed:19126755 - a(CHEBI:"(-)-epicatechin") decreases a(CHEBI:acrolein) + path(MESH:"Insulin Resistance") association path(MESH:"Tobacco Use Disorder") - - - - - pmid:23531502 + pubmed:19126755 - composite(a(CHEBI:cinnamaldehydes), p(HGNC:MAPT)) causesNoChange bp(GO:"microtubule polymerization") + path(MESH:"Insulin Resistance") increases path(MESH:"Diabetes Mellitus, Type 1") - pmid:23531502 + pubmed:21718217 - act(a(CHEBI:acrolein)) association a(GO:"neurofibrillary tangle") + path(MESH:"Insulin Resistance") association p(HGNC:PPARGC1A) - pmid:17082178 + pubmed:19126755 - a(CHEBI:acrolein) increases a(GO:"neurofibrillary tangle") + path(MESH:"Genetic Variation") association act(a(CHEBI:nicotine)) - pmid:23531502 + pubmed:19126755 - act(a(CHEBI:acrolein)) association path(MESH:"Plaque, Amyloid") + a(MESH:"Mice, Inbred Strains") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:23531502 + pubmed:19126755 - act(a(CHEBI:acrolein)) association a(HBP:"dystrophic neurite") + a(MESH:"Mice, Inbred Strains") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:23531502 + pubmed:19126755 - act(a(CHEBI:acrolein)) increases bp(GO:"neuron death") + a(MESH:"Rats, Inbred Strains") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:23531502 + pubmed:19126755 - act(a(CHEBI:acrolein)) increases p(HGNC:MAPT, pmod(Ph)) + path(MESH:"Neurofibrillary Tangles") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:23531502 + pubmed:24511233 - act(a(CHEBI:acrolein)) increases act(p(HGNC:GSK3B)) + path(MESH:"Neurofibrillary Tangles") biomarkerFor path(MESH:"Alzheimer Disease") - pmid:23531502 + pubmed:24590577 - act(a(CHEBI:acrolein)) increases act(p(HGNC:MAPK14)) + path(MESH:"Neurofibrillary Tangles") association path(MESH:"Alzheimer Disease") - pmid:23531502 + pubmed:24027553 - act(a(CHEBI:acrolein)) positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:"Neurofibrillary Tangles") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:17082178 + pubmed:24590577 - a(CHEBI:acrolein) increases complex(p(HGNC:MAPT), p(HGNC:MAPT)) + path(MESH:"Neurofibrillary Tangles") association bp(GO:"synaptic transmission, cholinergic") - pmid:17082178 + pubmed:24027553 - a(CHEBI:acrolein) increases a(HBP:"Tau oligomers") + path(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:26655600 + pubmed:24027553 - p(HBP:"Tau isoform F (441 aa)", pmod(HBP:glycation)) increases a(HBP:"Tau aggregates") + path(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) - pmid:26655600 + pubmed:24027553 - p(HBP:"Tau isoform F (441 aa)", pmod(HBP:glycation)) negativeCorrelation p(HBP:"Tau isoform F (441 aa)", pmod(Ph)) + path(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, pmod(CONSO:nitration)) - pmid:26655600 + pubmed:24027553 - p(HBP:"Tau isoform C (410 aa)", pmod(HBP:glycation)) increases a(HBP:"Tau aggregates") + path(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, frag("1_?")) - pmid:26655600 + pubmed:24027553 - p(HBP:"Tau isoform B (381 aa)", pmod(HBP:glycation)) decreases a(HBP:"Tau aggregates") + path(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, frag("?_*")) - pmid:26655600 + pubmed:24027553 - p(HBP:"Tau isoform B (381 aa)", pmod(HBP:glycation)) increases a(HBP:"Tau aggregates") + path(MESH:"Neurofibrillary Tangles") association a(CHEBI:Thrombin) - pmid:26655600 + pubmed:24027553 - p(HBP:"Tau isoform F (441 aa)", pmod(Ph)) negativeCorrelation p(HBP:"Tau isoform F (441 aa)", pmod(HBP:glycation)) + path(MESH:"Neurofibrillary Tangles") association p(HGNC:CAPN2) - pmid:26655600 + pubmed:24027553 - p(HBP:"Tau isoform D (383 aa)", pmod(HBP:glycation)) decreases a(HBP:"Tau aggregates") + path(MESH:"Neurofibrillary Tangles") positiveCorrelation act(p(HGNCGENEFAMILY:Caspases)) - pmid:26655600 + pubmed:24027553 - p(HBP:"Tau isoform D (383 aa)", pmod(Ph)) decreases a(HBP:"Tau aggregates") + path(MESH:"Neurofibrillary Tangles") association act(p(HGNCGENEFAMILY:Caspases)) - pmid:26655600 + pubmed:24027553 - p(HBP:"Tau isoform E (412 aa)", pmod(HBP:glycation)) decreases a(HBP:"Tau aggregates") + path(MESH:"Neurofibrillary Tangles") association p(CONSO:"Tau C3") - pmid:26655600 + pubmed:24027553 - p(HBP:"Tau isoform E (412 aa)", pmod(Ph)) decreases a(HBP:"Tau aggregates") + path(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) - pmid:26655600 + pubmed:19126755 - p(HBP:"Tau isoform B (381 aa)", pmod(Ph)) increases a(HBP:"Tau aggregates") + path(MESH:"Neurogenic Inflammation") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:26304819 + pubmed:30837838 - a(CHEBI:glyceraldehyde) increases r(HGNC:GAPDH) + path(MESH:"Neurogenic Inflammation") increases bp(GO:"mast cell degranulation") - pmid:26304819 + pubmed:19126755 - a(CHEBI:glyceraldehyde) increases bp(GO:"apoptotic process") + p(MGI:Chrnb2) negativeCorrelation path(CONSO:Neurodegeneration) - pmid:26304819 + pubmed:25514383 - a(CHEBI:glyceraldehyde) increases a(HBP:"GA-AGE") + p(MGI:Chrnb2) regulates bp(MESH:Homeostasis) - pmid:26304819 + pubmed:25514383 - a(CHEBI:glyceraldehyde) decreases a(CHEBI:"amyloid-beta polypeptide 42") + p(MGI:Chrnb2) increases a(MESH:"Cerebral Cortex") - pmid:26304819 + pubmed:25514383 - a(CHEBI:glyceraldehyde) increases p(HGNC:MAPT) + p(MGI:Chrnb2) increases path(MESH:Attention) - pmid:26304819 + pubmed:25514383 - a(CHEBI:glyceraldehyde) increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) + p(MGI:Chrnb2) increases bp(GO:cognition) - - - pmid:26304819 - - a(CHEBI:glyceraldehyde) increases p(HGNC:VEGFA) - - - pmid:26304819 + pubmed:27522251 - a(CHEBI:glyceraldehyde) increases p(HGNC:TGFB1) + p(MGI:Chrnb2) decreases path(MESH:"Memory Disorders") + + - pmid:26304819 + pubmed:27522251 - r(HGNC:GAPDH) association bp(GO:"apoptotic process") + p(MGI:Chrnb2) increases a(CHEBI:amyloid-beta) - pmid:26304819 + pubmed:19126755 - a(HBP:"GA-AGE") isA a(CHEBI:"advanced glycation end-product") + p(MGI:Chrna4) negativeCorrelation path(MESH:Aging) - pmid:26095350 + pubmed:19126755 - a(CHEBI:"D-ribose") increases a(CHEBI:"advanced glycation end-product") + act(p(HGNC:PTGS1)) increases a(CHEBI:"prostaglandin H2") - pmid:26095350 + pubmed:19126755 - a(CHEBI:"D-ribose") increases p(MGI:Mapt, pmod(Ph, Ser, 214)) + a(CHEBI:NS-398) increases p(HGNC:CHRNA4) - pmid:26095350 + pubmed:19126755 - a(CHEBI:"D-ribose") increases p(MGI:Mapt, pmod(Ph, Ser, 396)) + path(MESH:Tremor) positiveCorrelation path(MESH:"Parkinson Disease") - pmid:26095350 + pubmed:19126755 - a(CHEBI:"D-ribose") increases p(MGI:Mapt, pmod(Ph, Ser, 214), pmod(Ph, Ser, 396)) + path(MESH:Hypokinesia) positiveCorrelation path(MESH:"Parkinson Disease") - pmid:26095350 + pubmed:19126755 - a(CHEBI:"D-ribose") increases p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) + path(MESH:"Muscle Rigidity") positiveCorrelation path(MESH:"Parkinson Disease") - pmid:26095350 + pubmed:21722302 - a(CHEBI:"D-ribose") increases p(HGNC:MAPT, pmod(Ph, Ser, 214)) + path(MESH:"Muscle Rigidity") prognosticBiomarkerFor path(MESH:"Parkinson Disease") - pmid:28176663 + pubmed:17009926 - a(CHEBI:"D-ribose") increases p(HGNC:MAPT, pmod(Ph, Ser, 214)) + path(MESH:"Behavior, Addictive") association p(FPLX:CHRN) - pmid:26095350 + pubmed:29428175 - a(CHEBI:"D-ribose") increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + path(MESH:"Behavior, Addictive") association complex(complex(GO:"heterotrimeric G-protein complex"), p(HGNC:CHRNA7)) - pmid:28176663 + pubmed:19721446 - a(CHEBI:"D-ribose") increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + path(MESH:Craving) association p(HGNC:CHRNA3) - pmid:26095350 + pubmed:19721446 - a(CHEBI:"D-ribose") increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) + path(MESH:Craving) association p(HGNC:CHRNB4) - pmid:28176663 + pubmed:19126755 - a(CHEBI:"D-ribose") increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) + p(CONSO:"beta-2-containing nAChR") association a(CHEBI:nicotine) - pmid:26095350 + pubmed:19126755 - a(CHEBI:"D-ribose") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + p(CONSO:"beta-2-containing nAChR") causesNoChange act(a(CHEBI:nicotine)) + + - pmid:26095350 + pubmed:19126755 - a(CHEBI:"D-ribose") increases p(MGI:Camk2b, pmod(Ph, Thr, 286), pmod(Ph, Thr, 287)) + path(MESH:"Drug Tolerance") association p(HGNC:CHRNB4) - pmid:26095350 + pubmed:19126755 - a(CHEBI:"D-ribose") decreases p(MGI:Camk2b, pmod(Ph, Thr, 305), pmod(Ph, Thr, 306)) + path(MESH:"Drug Tolerance") association p(CONSO:"alpha-4-containing nAChR") - pmid:19517062 + pubmed:27758088 - a(CHEBI:"D-ribose") increases p(HGNC:MAPT, pmod(HBP:glycation)) + a(UBERON:0000010) association r(HGNC:CHRNB4) - pmid:28176663 + pubmed:27758088 - a(CHEBI:"D-ribose") increases a(HBP:"advanced glycation end product") + r(MESH:"long non-coding RNA RP11-650L12.2, human") association r(HGNC:CHRNA3) - pmid:26095350 + pubmed:27758088 - p(MGI:Camk2b, pmod(Ph, Thr, 286), pmod(Ph, Thr, 287)) increases act(p(MGI:Camk2b)) + r(MESH:"long non-coding RNA RP11-650L12.2, human") association r(HGNC:CHRNA5) - - - - - pmid:26095350 + pubmed:27758088 - p(MGI:Camk2b, pmod(Ph, Thr, 305), pmod(Ph, Thr, 306)) decreases act(p(MGI:Camk2b)) + g(DBSNP:rs880395) increases r(HGNC:CHRNA5) - pmid:22798221 + pubmed:27758088 - a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Ser, 404)) + g(DBSNP:rs880395) increases r(HGNC:CHRNA5) - pmid:22798221 + pubmed:27758088 - a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Ser, 198)) + g(DBSNP:rs880395) increases r(HGNC:CHRNA5) - pmid:22798221 + pubmed:27758088 - a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Ser, 199)) + g(DBSNP:rs880395) increases r(MESH:"long non-coding RNA RP11-650L12.2, human") - pmid:22798221 + pubmed:27758088 - a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Ser, 202)) + g(DBSNP:rs880395) increases r(MESH:"long non-coding RNA RP11-650L12.2, human") - pmid:22798221 + pubmed:27758088 - a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Thr, 231)) + g(DBSNP:rs880395) increases r(HGNC:CHRNA3) - pmid:22798221 + pubmed:27758088 - a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Ser, 396)) + g(DBSNP:rs880395) causesNoChange r(HGNC:CHRNA3) - pmid:22798221 + pubmed:27758088 - a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Thr, 205)) + g(DBSNP:rs880395) increases r(HGNC:CHRNA3) - pmid:22798221 + pubmed:27758088 - a(CHEBI:methylglyoxal) increases a(CHEBI:"advanced glycation end-product") + g(DBSNP:rs880395) decreases p(HGNC:PSMA4) - pmid:22798221 + pubmed:27758088 - a(CHEBI:methylglyoxal) increases p(HGNC:AGER) + g(DBSNP:rs880395) decreases path(MESH:"Tobacco Use Disorder") + + - pmid:22798221 + pubmed:27758088 - a(CHEBI:methylglyoxal) increases act(p(MGI:Gsk3b), ma(kin)) + g(DBSNP:rs1948) increases r(HGNC:CHRNA3) - pmid:22798221 + pubmed:27758088 - a(CHEBI:methylglyoxal) increases act(p(MGI:Mapk14), ma(kin)) + g(DBSNP:rs1948) increases r(HGNC:CHRNA3) - pmid:19251756 + pubmed:27758088 - a(CHEBI:methylglyoxal) negativeCorrelation act(p(INTERPRO:"Triosephosphate isomerase")) + g(DBSNP:rs1948) increases r(HGNC:CHRNA3) - pmid:17082178 + pubmed:27758088 - a(CHEBI:methylglyoxal) increases a(GO:"neurofibrillary tangle") + g(DBSNP:rs1948) increases r(MESH:"long non-coding RNA RP11-650L12.2, human") - pmid:17082178 + pubmed:27758088 - a(CHEBI:methylglyoxal) increases complex(p(HGNC:MAPT), p(HGNC:MAPT)) + g(DBSNP:rs1948) increases path(MESH:"Tobacco Use Disorder") + + - pmid:17082178 + pubmed:27758088 - a(CHEBI:methylglyoxal) increases a(HBP:"Tau oligomers") + g(DBSNP:rs16969968) increases path(MESH:"Tobacco Use Disorder") - pmid:22798221 + pubmed:27758088 - act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 404)) + g(DBSNP:rs16969968) increases path(MESH:"Tobacco Use Disorder") - pmid:22798221 + pubmed:28901280 - act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 198)) + g(DBSNP:rs16969968) association act(a(MESH:Nicotine)) - pmid:22798221 + pubmed:27758088 - act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 199)) + composite(g(DBSNP:rs880395), r(HGNC:CHRNA5)) decreases path(MESH:"Tobacco Use Disorder") - pmid:22798221 + pubmed:27758088 - act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 202)) + composite(g(DBSNP:rs1948), r(HGNC:CHRNA3)) increases path(MESH:"Tobacco Use Disorder") - pmid:22798221 + pubmed:18986241 - act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 231)) + path(MESH:"Psychomotor Performance") positiveCorrelation a(MESH:"Frontal Lobe") - pmid:22798221 + pubmed:19293145 - act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 396)) + path(MESH:Death) association path(MESH:"Alzheimer Disease") - pmid:22798221 + pubmed:19293145 - act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 205)) + a(MESH:"Neurofibrillary Tangles") positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:22798221 + pubmed:18986241 - act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) + a(MESH:"Neurofibrillary Tangles") association path(MESH:"Alzheimer Disease") - - - - - pmid:19251756 + pubmed:19293145 - act(p(INTERPRO:"Triosephosphate isomerase")) increases rxn(reactants(a(CHEBI:"D-glyceraldehyde 3-phosphate"), a(CHEBI:"dihydroxyacetone phosphate")), products(a(CHEBI:ATP))) + a(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT) - pmid:19251756 + pubmed:14556719 - p(INTERPRO:"Triosephosphate isomerase") partOf bp(GO:"canonical glycolysis") + a(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT) - pmid:19251756 + pubmed:14556719 - act(p(INTERPRO:"Triosephosphate isomerase")) negativeCorrelation path(HBP:Neurodegeneration) + a(MESH:"Neurofibrillary Tangles") increases p(HGNC:MAPT) - - - - - pmid:19251756 + pubmed:27574109 - act(p(INTERPRO:"Triosephosphate isomerase")) negativeCorrelation a(CHEBI:methylglyoxal) + a(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT) - - - - - - - - - pmid:19251756 + pubmed:18986241 - bp(GO:"canonical glycolysis") negativeCorrelation path(MESH:"Alzheimer Disease") + a(MESH:"Neurofibrillary Tangles") association path(MESH:"Cholinergic Neurons") - pmid:19251756 + pubmed:18986241 - bp(GO:"response to nitrosative stress") increases p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 164)) + a(MESH:"Neurofibrillary Tangles") association p(HGNC:BCHE) - pmid:19251756 + pubmed:18986241 - bp(GO:"response to nitrosative stress") increases p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 208)) + a(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:21210655 + pubmed:21722302 - bp(GO:"response to nitrosative stress") increases p(HGNC:MAPT, pmod(HBP:formylation, Lys)) + a(MESH:"Neurofibrillary Tangles") increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:19251756 + pubmed:21722302 - p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 164)) positiveCorrelation path(MESH:"Alzheimer Disease") + a(MESH:"Neurofibrillary Tangles") increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:19251756 + pubmed:14556719 - p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 164)) decreases act(p(INTERPRO:"Triosephosphate isomerase")) + a(MESH:"Neurofibrillary Tangles") increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:19251756 + pubmed:26195256 - p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 164)) decreases act(p(INTERPRO:"Triosephosphate isomerase")) + a(MESH:"Neurofibrillary Tangles") association p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:19251756 + pubmed:22299660 - p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 164)) increases a(CHEBI:methylglyoxal) + a(MESH:"Neurofibrillary Tangles") association p(FPLX:PPP2C, pmod(go:0006468 ! "protein phosphorylation")) - pmid:19251756 + pubmed:14556719 - p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 208)) positiveCorrelation path(MESH:"Alzheimer Disease") + a(MESH:"Neurofibrillary Tangles") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) - pmid:19251756 + pubmed:14556719 - p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 208)) decreases act(p(INTERPRO:"Triosephosphate isomerase")) + a(MESH:"Neurofibrillary Tangles") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) - pmid:19251756 + pubmed:27574109 - p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 208)) decreases act(p(INTERPRO:"Triosephosphate isomerase")) + a(MESH:"Neurofibrillary Tangles") association a(CONSO:"Tau oligomers") - pmid:19251756 + pubmed:27574109 - p(INTERPRO:"Triosephosphate isomerase", pmod(NO, Tyr, 208)) increases a(CHEBI:methylglyoxal) + a(MESH:"Neurofibrillary Tangles") association p(CONSO:"phosphatase-activating domain") - pmid:19251756 + pubmed:23528736 - p(INTERPRO:"Triosephosphate isomerase", pmod(NO)) association p(HGNC:MAPT) + a(MESH:"Neurofibrillary Tangles") association p(CONSO:"UBB+1") + + - pmid:19251756 + pubmed:19293145 - p(INTERPRO:"Triosephosphate isomerase", pmod(NO)) partOf complex(p(HGNC:MAPT), p(INTERPRO:"Triosephosphate isomerase", pmod(NO))) + p(CHEBI:amyloid-beta, var("?")) increases a(CONSO:"amyloid-beta aggregates") @@ -154914,350 +156440,342 @@

Statements

- pmid:19251756 + pubmed:19293145 - complex(p(HGNC:MAPT), p(INTERPRO:"Triosephosphate isomerase", pmod(NO))) positiveCorrelation a(CHEBI:"amyloid-beta") + a(CHEBI:"EC 3.1.1.8 (cholinesterase) inhibitor") decreases path(MESH:"Alzheimer Disease") - pmid:19251756 + pubmed:16273023 - complex(p(HGNC:MAPT), p(INTERPRO:"Triosephosphate isomerase", pmod(NO))) partOf a(GO:"neurofibrillary tangle") + a(CHEBI:"NMDA receptor antagonist") association bp(GO:"GO:0035249") - - - - - pmid:18494933 + pubmed:16273023 - complex(p(HGNC:AGER), p(HGNC:S100B)) increases p(FPLX:JNK, pmod(Ph)) + a(CHEBI:"NMDA receptor antagonist") decreases act(a(MESH:D009474)) - pmid:17082178 + pubmed:21882945 - a(CHEBI:glyoxal) increases complex(p(HGNC:MAPT), p(HGNC:MAPT)) + a(CHEBI:"NMDA receptor antagonist") positiveCorrelation bp(GO:cognition) - pmid:17082178 + pubmed:19293145 - a(CHEBI:glyoxal) increases a(HBP:"Tau oligomers") + composite(p(CONSO:gamma-secretase), p(HGNC:APP), p(HGNC:BACE1)) directlyIncreases composite(a(CHEBI:"amyloid-beta polypeptide 40"), a(CHEBI:"amyloid-beta polypeptide 42")) - pmid:17082178 + pubmed:19293145 - a(CHEBI:glyoxal) causesNoChange a(GO:"neurofibrillary tangle") + a(CONSO:"Abeta*56") decreases path(MESH:"Maze Learning") - pmid:17082178 + pubmed:19293145 - a(CHEBI:malonaldehyde) increases complex(p(HGNC:MAPT), p(HGNC:MAPT)) + g(HGNC:CHAT) association path(MESH:"Alzheimer Disease") - pmid:17082178 + pubmed:19293145 - a(CHEBI:malonaldehyde) increases a(HBP:"Tau oligomers") + g(HGNC:ACHE) association path(MESH:"Alzheimer Disease") - pmid:17082178 + pubmed:18986241 - a(CHEBI:malonaldehyde) causesNoChange a(GO:"neurofibrillary tangle") + path(MESH:Cognition) association p(HGNC:BCHE) - pmid:16630055 + pubmed:18986241 - path(MESH:Fasting) decreases p(MGI:Mapt, pmod(HBP:"O-GlcNAcylation")) + path(MESH:Cognition) association g(HGNC:NTRK1) - pmid:16630055 + pubmed:18986241 - path(MESH:Fasting) increases p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) + path(MESH:Cognition) association g(HGNC:NTRK2) - pmid:12578227 + pubmed:18986241 - p(HGNC:TGM1) positiveCorrelation a(GO:"neurofibrillary tangle") + path(MESH:Cognition) association g(HGNC:NTRK3) - pmid:12578227 + pubmed:18986241 - p(HGNC:TGM1) isA p(ECCODE:"2.3.2.13") + path(MESH:Cognition) negativeCorrelation r(HGNC:CHRNA7) - pmid:12578227 + pubmed:18986241 - p(HBP:"TGM2 Isoform 3 (349 aa)") isA r(HGNC:TGM2) + path(MESH:Cognition) association act(p(HGNC:GAL)) - pmid:12578227 + pubmed:29687724 - p(HGNC:TGM2) positiveCorrelation a(GO:"neurofibrillary tangle") + path(MESH:Cognition) association path(MESH:"Huntington Disease") - pmid:12578227 + pubmed:19293145 - p(HGNC:TGM2) isA p(ECCODE:"2.3.2.13") + a(CHEBI:dihydro-beta-erythroidine) decreases act(a(CHEBI:nicotine)) - pmid:10537045 + pubmed:19293145 - p(HGNC:TGM2) positiveCorrelation p(HGNC:MAPT) + a(CHEBI:dihydro-beta-erythroidine) decreases act(a(CHEBI:nicotine)) - pmid:10537045 + pubmed:19293145 - p(HGNC:TGM2) partOf complex(p(HGNC:MAPT), p(HGNC:TGM2)) + a(CHEBI:dihydro-beta-erythroidine) decreases act(p(CONSO:"alpha-4 beta-2 nAChR")) - pmid:10537045 + pubmed:19293145 - act(p(HGNC:TGM2)) association p(HBP:"microtubule-binding region") + a(CHEBI:dihydro-beta-erythroidine) decreases bp(MESH:Neuroprotection) - pmid:11089576 + pubmed:17009926 - act(p(ECCODE:"2.3.2.13")) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") + a(CHEBI:dihydro-beta-erythroidine) decreases act(p(HGNC:CHRNB2)) - pmid:11089576 + pubmed:17009926 - act(p(ECCODE:"2.3.2.13")) positiveCorrelation a(GO:"neurofibrillary tangle") + a(CHEBI:dihydro-beta-erythroidine) decreases bp(GO:memory) - pmid:11738469 + pubmed:19293145 - act(p(ECCODE:"2.3.2.13")) positiveCorrelation a(GO:"neurofibrillary tangle") + a(CHEBI:Mecamylamine) decreases act(a(CHEBI:nicotine)) - pmid:8985134 + pubmed:28391535 - act(p(ECCODE:"2.3.2.13")) positiveCorrelation a(GO:"neurofibrillary tangle") + a(CHEBI:Mecamylamine) decreases act(a(CHEBI:nicotine)) - pmid:11738469 + pubmed:17009926 - act(p(ECCODE:"2.3.2.13")) positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:Mecamylamine) isA a(CHEBI:"nicotinic antagonist") - pmid:8985134 + pubmed:17009926 - act(p(ECCODE:"2.3.2.13")) positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:Mecamylamine) decreases path(MESH:Attention) - pmid:9099822 + pubmed:26813123 - act(p(HGNCGENEFAMILY:Transglutaminases)) positiveCorrelation a(GO:"neurofibrillary tangle") + a(CHEBI:Mecamylamine) decreases act(a(MESH:"Hypothalamo-Hypophyseal System")) - - - - - pmid:10537045 + pubmed:11230871 - complex(p(HGNC:MAPT), p(HGNC:TGM2)) positiveCorrelation a(CHEBI:"calcium(2+)") + a(CHEBI:Mecamylamine) decreases bp(GO:cognition) - pmid:10537045 + pubmed:19721446 - a(HBP:maitotoxin) increases a(CHEBI:"calcium(2+)") + a(CHEBI:Mecamylamine) decreases bp(GO:cognition) - pmid:10537045 + pubmed:28391535 - a(HBP:maitotoxin) increases act(p(HGNC:TGM2)) + a(CHEBI:Mecamylamine) decreases act(a(MESH:"Receptors, Nicotinic")) - pmid:22057784 + pubmed:28391535 - p(HGNC:MAPT, pmod(NO, Tyr, 29)) positiveCorrelation path(MESH:"Pick Disease of the Brain") + a(CHEBI:Mecamylamine) decreases act(a(MESH:"Receptors, Nicotinic")) - pmid:17768677 + pubmed:28391535 - p(RGD:Mapt, pmod(HBP:nitration, Tyr, 507)) partOf a(MESH:Brain) + a(CHEBI:Mecamylamine) decreases path(MESH:Hypertension) - pmid:16816118 + pubmed:28391535 - a(CHEBI:linsidomine) increases a(CHEBI:peroxynitrite) + a(CHEBI:Mecamylamine) increases path(MESH:Tremor) - pmid:16816118 + pubmed:28391535 - a(CHEBI:linsidomine) decreases act(p(HBP:"20 S Proteasome")) + a(CHEBI:Mecamylamine) increases path(MESH:Confusion) - pmid:16816118 + pubmed:28391535 - p(RGD:Mapt, pmod(HBP:hyperphosphorylation)) increases a(HBP:"Tau aggregates") + a(CHEBI:Mecamylamine) increases path(MESH:Seizures) - pmid:16816118 + pubmed:28391535 - p(RGD:Mapt, pmod(HBP:nitration)) increases a(HBP:"Tau aggregates") + a(CHEBI:Mecamylamine) increases path(MESH:"Bipolar Disorder") - pmid:16816118 + pubmed:28391535 - a(CHEBI:"uric acid") decreases p(RGD:Mapt, pmod(HBP:hyperphosphorylation)) + a(CHEBI:Mecamylamine) increases path(MESH:Depression) - pmid:16816118 + pubmed:28391535 - a(CHEBI:"uric acid") decreases p(RGD:Mapt, pmod(HBP:nitration)) + a(CHEBI:Mecamylamine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:16816118 + pubmed:23038257 - a(CHEBI:"uric acid") decreases act(a(CHEBI:peroxynitrite)) + bp(GO:"intracellular receptor signaling pathway") association p(HGNC:CHRNA4) @@ -155266,238 +156784,192 @@

Statements

- pmid:16566606 + pubmed:19293145 - p(HGNC:MAPT, pmod(Ph, Tyr, 29)) positiveCorrelation a(GO:microtubule) + a(MESH:Bungarotoxins) decreases act(a(CHEBI:amyloid-beta)) - pmid:16566606 + pubmed:19293145 - a(HBP:"3-3 dityrosine cross-linking") positiveCorrelation a(HBP:"paired helical filaments") + a(MESH:Bungarotoxins) decreases complex(a(CHEBI:amyloid-beta), p(HGNC:CHRNA7)) - pmid:27796283 + pubmed:19293145 - act(p(HGNC:RHOA)) regulates bp(GO:"dendritic spine development") + act(a(MESH:Bungarotoxins)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - - - pmid:27796283 - - act(p(HGNC:RHOA)) association act(p(HGNC:ARHGEF2)) - - - pmid:27796283 + pubmed:23038257 - act(p(HGNC:RHOA)) negativeCorrelation a(MESH:"Dendritic Spines") + a(MESH:Bungarotoxins) decreases bp(GO:"neuromuscular synaptic transmission") - pmid:27796283 + pubmed:23038257 - act(p(HGNC:RHOA)) regulates a(MESH:"Dendritic Spines") + a(MESH:Bungarotoxins) decreases act(a(MESH:"Electric Organ")) - pmid:27796283 + pubmed:23038257 - act(p(HGNC:RHOA)) negativeCorrelation act(a(GO:synapse)) + a(MESH:Bungarotoxins) decreases act(a(CHEBI:decamethonium)) - - - pmid:27796283 - - act(p(HGNC:RHOA)) positiveCorrelation complex(p(HGNC:ARHGEF2), p(HGNC:RHOA)) - - - - - pmid:27796283 - - bp(GO:"dendritic spine development") positiveCorrelation a(MESH:"Dendritic Spines") - + - - - pmid:27796283 - - p(HGNC:TIAM1, pmod(Ph)) increases act(p(HGNC:RAC1)) - + - - - pmid:27796283 - - p(HBP:"Kalirin 7", pmod(Ph, Thr, 95)) increases act(p(HBP:"Kalirin 7")) - + - - - pmid:27796283 - - act(p(HBP:"Kalirin 7")) increases act(p(HGNC:RAC1)) - + - pmid:27796283 + pubmed:25514383 - p(HGNC:CAMK1) increases p(HGNC:ARHGEF7, pmod(Ph, Ser, 516)) + a(MESH:Bungarotoxins) decreases complex(a(CHEBI:amyloid-beta), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) - - - pmid:27796283 - - p(HGNC:ARHGEF7, pmod(Ph, Ser, 516)) increases act(p(HGNC:ARHGEF7)) - - - - - pmid:27796283 - - act(p(HGNC:ARHGEF7)) increases act(p(HGNC:RAC1)) - + - pmid:27796283 + pubmed:19293145 - complex(GO:"AMPA glutamate receptor complex") decreases act(p(HGNC:ARHGEF2)) + composite(a(CHEBI:"3',5'-cyclic AMP"), p(FPLX:PKC)) increases p(HGNC:CHRNA7) - pmid:27796283 + pubmed:19293145 - complex(GO:"AMPA glutamate receptor complex") association act(p(HGNC:ARHGEF2)) + act(a(CHEBI:ethanol)) increases path(CONSO:neurotoxicity) - pmid:27796283 + pubmed:19293145 - complex(GO:"AMPA glutamate receptor complex") regulates act(p(HGNC:RHOA)) + a(MESH:Serum) decreases bp(GO:"cell death") - pmid:27796283 + pubmed:19293145 - act(p(HGNC:ARHGEF2)) association act(p(HGNC:RHOA)) + a(CHEBI:thapsigargin) increases bp(GO:"cell death") - pmid:27796283 + pubmed:19293145 - act(p(HGNC:ARHGEF2)) association complex(GO:"AMPA glutamate receptor complex") + a(CHEBI:thapsigargin) decreases bp(GO:"sarcoplasmic reticulum calcium ion transport") - pmid:27796283 + pubmed:20556492 - act(p(HGNC:ARHGEF2)) regulates a(MESH:"Dendritic Spines") + a(CHEBI:thapsigargin) decreases bp(GO:"regulation of membrane potential") - pmid:27796283 + pubmed:20556492 - act(p(HGNC:ARHGEF2)) regulates a(MESH:"Dendritic Spines") + a(CHEBI:thapsigargin) increases path(HP:"Increased reactive oxygen species production") - pmid:27796283 + pubmed:28148553 - act(p(HGNC:CAMKV)) decreases complex(p(HGNC:ARHGEF2), p(HGNC:RHOA)) + a(CHEBI:thapsigargin) increases bp(MESH:"Unfolded Protein Response") - pmid:27796283 + pubmed:28148553 - act(p(HGNC:CAMKV)) decreases act(p(HGNC:RHOA)) + a(CHEBI:thapsigargin) positiveCorrelation p(HGNC:EIF2AK3, pmod(go:0006468 ! "protein phosphorylation")) - pmid:27796283 + pubmed:28148553 - p(HGNC:CAMKV) positiveCorrelation a(MESH:"Dendritic Spines") + a(CHEBI:thapsigargin) positiveCorrelation p(HGNC:EIF2A, pmod(go:0006468 ! "protein phosphorylation")) - pmid:27796283 + pubmed:21722302 - act(p(HGNC:CAMKV)) regulates a(MESH:"Dendritic Spines") + a(CHEBI:thapsigargin) increases bp(GO:autophagy) @@ -155506,18 +156978,18 @@

Statements

- pmid:27796283 + pubmed:30740335 - p(HGNC:CAMKV) regulates bp(GO:"neuron-neuron synaptic transmission") + a(CHEBI:thapsigargin) increases path(MESH:"Endoplasmic Reticulum Stress") - pmid:27796283 + pubmed:29024336 - p(HGNC:CAMKV) association bp(MESH:"Long-Term Potentiation") + a(CHEBI:thapsigargin) increases bp(GO:"response to endoplasmic reticulum stress") @@ -155526,404 +156998,381 @@

Statements

+ + - pmid:27796283 + pubmed:19293145 - complex(p(HGNC:ARHGEF2), p(HGNC:RHOA)) positiveCorrelation act(p(HGNC:RHOA)) + act(a(CHEBI:"L-glutamate(2-)")) increases path(CONSO:neurotoxicity) - pmid:27796283 + pubmed:19293145 - p(HGNC:CAMKV, pmod(Ph, Thr, 345)) decreases act(p(HGNC:CAMKV)) + act(a(CHEBI:"L-glutamate(2-)")) increases path(CONSO:neurotoxicity) - - - - - - - pmid:29121589 + pubmed:19293145 - complex(p(HGNC:CUL3), p(HGNC:KEAP1), p(HGNC:NFE2L2)) regulates deg(p(HGNC:NFE2L2)) + act(a(MESH:"Vagus Nerve")) increases act(p(HGNC:CHRNA7)) - pmid:29121589 + pubmed:19293145 - complex(p(HGNC:CUL3), p(HGNC:KEAP1), p(HGNC:NFE2L2)) regulates p(HGNC:NFE2L2, pmod(Ub)) + bp(GO:"negative regulation of apoptotic process") association a(CHEBI:nicotine) - pmid:29121589 + pubmed:19293145 - p(HGNC:CUL3) partOf complex(p(HGNC:CUL3), p(HGNC:KEAP1), p(HGNC:NFE2L2)) + p(FPLX:SRC) increases act(a(CHEBI:nicotine)) - pmid:29121589 + pubmed:17009926 - p(HGNC:NFE2L2, pmod(Ub)) regulates deg(p(HGNC:NFE2L2)) + act(p(FPLX:SRC), ma(go:0016301 ! "kinase activity")) increases p(HGNC:CHRNA7, pmod(go:0006468 ! "protein phosphorylation")) - pmid:29121589 + pubmed:22040696 - p(HGNC:NFE2L2, pmod(Ph)) partOf complex(p(HGNC:BTRC), p(HGNC:CUL1), p(HGNC:NFE2L2, pmod(Ph))) + act(p(FPLX:SRC), ma(go:0016301 ! "kinase activity")) increases p(FPLX:CHRN, pmod(go:0006468 ! "protein phosphorylation", Tyr)) - pmid:29121589 + pubmed:22040696 - p(HGNC:BTRC) increases complex(p(HGNC:BTRC), p(HGNC:CUL1), p(HGNC:NFE2L2, pmod(Ph))) + act(p(FPLX:SRC), ma(go:0016301 ! "kinase activity")) increases p(FPLX:CHRN, pmod(go:0006468 ! "protein phosphorylation", Tyr)) + + - pmid:29121589 + pubmed:19293145 - p(HGNC:BTRC) isA p(ECCODE:"2.3.2.27") + a(MESH:"Nicotinic Antagonists") decreases bp(MESH:Neuroprotection) + + - pmid:25546293 + pubmed:19293145 - act(p(HGNC:BTRC)) increases p(HGNC:CTNNB1, pmod(Ub)) + tloc(p(HGNC:BAX), fromLoc(GO:cytosol), toLoc(GO:mitochondrion)) increases bp(GO:"apoptotic process") - - - - - pmid:29121589 + pubmed:21722302 - complex(p(HGNC:BTRC), p(HGNC:CUL1), p(HGNC:NFE2L2, pmod(Ph))) increases p(HGNC:NFE2L2, pmod(Ub)) + p(HGNC:BAX) increases act(p(HGNC:ERN1), ma(go:0016301 ! "kinase activity")) - pmid:29121589 + pubmed:21722302 - complex(p(HGNC:BTRC), p(HGNC:CUL1), p(HGNC:NFE2L2, pmod(Ph))) increases deg(p(HGNC:NFE2L2)) + p(HGNC:BAX) increases act(p(HGNC:ERN1), ma(MESH:Endoribonucleases)) - pmid:29121589 + pubmed:21722302 - p(FPLX:p38, pmod(Ph)) increases act(p(FPLX:p38)) + p(HGNC:BAX) association bp(MESH:Apoptosis) - - - pmid:26400044 + pubmed:21722302 - p(MGI:Dpysl2, pmod(Ph)) partOf complex(p(HBP:"Tau aggregates"), p(MGI:Dpysl2, pmod(Ph)), p(MGI:Wasf1, pmod(Ph))) + p(HGNC:BAX) increases bp(GO:"mitochondrial outer membrane permeabilization") - pmid:26400044 + pubmed:21722302 - p(MGI:Dpysl2, pmod(Ph)) partOf complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt, pmod(HBP:hyperphosphorylation)), p(MGI:Wasf1, pmod(Ph))) + p(HGNC:BAX) increases complex(GO:"mitochondrial permeability transition pore complex") - - - pmid:24401760 - - path(HBP:Astrogliosis) positiveCorrelation path(MESH:"Alzheimer Disease") - + - - - pmid:29121589 - - r(MGI:Il1b) biomarkerFor bp(GO:"inflammatory response") - + + + - pmid:29121589 + pubmed:19293145 - r(MGI:Nos2) biomarkerFor bp(GO:"inflammatory response") + complex(p(FPLX:AKT), p(HGNC:AGAP2)) increases act(p(FPLX:AKT)) - pmid:27807169 + pubmed:19293145 - bp(GO:"histone acetylation") increases p(RGD:Cdk5r2) + p(MGI:Fyn) decreases bp(MESH:Neuroprotection) + + - pmid:27807169 + pubmed:18096814 - p(RGD:Cdk5r2) directlyIncreases act(p(RGD:Cdk5)) + p(MGI:Fyn, loc(GO:"membrane raft")) negativeCorrelation a(CHEBI:"2-bromohexadecanoic acid") - pmid:27807169 + pubmed:18096814 - p(RGD:Cdk5r2) positiveCorrelation a(GO:"dendritic spine") + p(MGI:Fyn) regulates tloc(p(MGI:Mapt), fromLoc(GO:cytoplasm), toLoc(GO:"membrane raft")) - pmid:27807169 + pubmed:25125464 - p(RGD:Cdk5r2) positiveCorrelation a(GO:axon) + p(MGI:Fyn) positiveCorrelation a(GO:"neuron spine") - pmid:27807169 + pubmed:25125464 - p(RGD:Cdk5r2) positiveCorrelation bp(GO:"synapse assembly") + p(MGI:Fyn) increases p(MGI:Grin2b, pmod(go:0006468 ! "protein phosphorylation", Tyr, 1472)) - pmid:27807169 + pubmed:25125464 - act(p(RGD:Cdk5)) positiveCorrelation bp(GO:"neuron differentiation") + act(p(MGI:Fyn)) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) - pmid:21489990 + pubmed:25125464 - act(p(RGD:Cdk5)) increases p(RGD:Mapt, pmod(Ph, Ser, 396)) + act(p(MGI:Fyn)) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) - pmid:21489990 + pubmed:19293145 - act(p(RGD:Cdk5)) increases p(RGD:Mapt, pmod(Ph, Ser, 404)) + p(HGNC:JAK2) increases bp(MESH:Neuroprotection) - pmid:21489990 + pubmed:19293145 - act(p(RGD:Cdk5)) increases p(RGD:Mapt, pmod(Ph, Ser, 262)) + p(HGNC:JAK2) association bp(MESH:Neuroprotection) - - - - - - - pmid:7514173 + pubmed:19293145 - a(CHEBI:"glycerol 2-phosphate") decreases act(p(HGNC:GSK3B), ma(kin)) + p(HGNC:JAK2) association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:7514173 + pubmed:19293145 - a(CHEBI:"diethyl pyrocarbonate") decreases act(p(HGNC:GSK3B), ma(kin)) + p(HGNC:JAK2) association act(p(HGNC:STAT3)) - pmid:7514173 + pubmed:26979166 - a(CHEBI:"pyridoxal 5'-phosphate") decreases act(p(HGNC:GSK3B), ma(kin)) + act(p(HGNC:JAK2)) directlyIncreases act(p(HGNC:STAT3)) - pmid:7514173 + pubmed:19293145 - a(CHEBI:Phenylglyoxal) decreases act(p(HGNC:GSK3B), ma(kin)) + act(p(HGNC:JAK2)) regulates act(a(CHEBI:nicotine)) - - - pmid:7514173 - - a(CHEBI:"poly(lysine) polymer") decreases act(p(HGNC:GSK3B), ma(kin)) - + - pmid:7514173 + pubmed:19293145 - a(CHEBI:"sodium chloride") decreases act(p(HGNC:GSK3B), ma(kin)) + p(HGNC:JAK2) increases act(p(HGNC:FYN)) - pmid:7514173 + pubmed:26979166 - a(CHEBI:"sodium fluoride") decreases act(p(HGNC:GSK3B), ma(kin)) + act(p(HGNC:JAK2)) directlyIncreases p(FPLX:"PI3K_p85", pmod(go:0006468 ! "protein phosphorylation", Tyr)) - pmid:7514173 + pubmed:26979166 - a(CHEBI:"manganese(II) chloride") decreases act(p(HGNC:GSK3B), ma(kin)) + act(p(HGNC:JAK2)) decreases act(p(MESH:"NF-kappa B")) - pmid:7514173 + pubmed:26979166 - a(CHEBI:"calcium dichloride") decreases act(p(HGNC:GSK3B), ma(kin)) + act(p(HGNC:JAK2)) increases act(p(HGNC:GABPA), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) + + - pmid:17078951 + pubmed:19293145 - p(HGNC:MAPT, pmod(Ph, Thr, 217)) positiveCorrelation p(FPLX:PKA) + complex(p(HGNC:FYN), p(HGNC:MAPT)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:22072628 + pubmed:24653673 - p(HGNC:MAPT, pmod(Ph, Thr, 217)) partOf p(HBP:"proline-rich region 2", pmod(Ph)) + complex(p(HGNC:FYN), p(HGNC:MAPT)) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:9089387 + pubmed:26631930 - p(FPLX:PDH, pmod(Ph)) negativeCorrelation act(p(FPLX:PDH, pmod(Ph))) + complex(p(HGNC:FYN), p(HGNC:MAPT)) regulates path(CONSO:Excitotoxicity) - pmid:9089387 + pubmed:18680553 - act(p(FPLX:PDH, pmod(Ph))) negativeCorrelation p(FPLX:PDH, pmod(Ph)) + complex(p(HGNC:FYN), p(HGNC:MAPT)) positiveCorrelation bp(GO:myelination) - pmid:9089387 + pubmed:19293145 - p(FPLX:PDH, pmod(Ph)) decreases rxn(reactants(a(CHEBI:pyruvate)), products(a(CHEBI:"acetyl-CoA"))) + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr)) association p(HGNC:PTK2, pmod(go:0006468 ! "protein phosphorylation")) - - - pmid:9089387 + pubmed:26631930 - p(FPLX:PDH) partOf bp(GO:"canonical glycolysis") + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr)) increases a(CONSO:"Tau aggregates") @@ -155932,1455 +157381,1248 @@

Statements

- - - - - pmid:22102280 + pubmed:19293145 - a(HBP:tideglusib) decreases act(p(HGNC:GSK3B), ma(kin)) + p(HGNC:PTK2, pmod(go:0006468 ! "protein phosphorylation")) association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr)) - pmid:22102280 + pubmed:19293145 - a(CHEBI:hypothemycin) decreases act(p(HGNC:GSK3B), ma(kin)) + p(HGNC:PTK2, pmod(go:0006468 ! "protein phosphorylation")) decreases act(p(HGNC:PTK2)) - pmid:22102280 + pubmed:19293145 - a(CHEBI:alsterpaullone) decreases act(p(HGNC:GSK3B), ma(kin)) + p(HGNC:CHRNA7, pmod(go:0006468 ! "protein phosphorylation")) decreases act(a(CHEBI:acetylcholine)) - pmid:10998059 + pubmed:23038257 - a(CHEBI:alsterpaullone) decreases act(p(HGNC:GSK3B), ma(kin)) + p(HGNC:CHRNA7, pmod(go:0006468 ! "protein phosphorylation")) increases act(a(MESH:"Motor Endplate"), ma(GO:localization)) - pmid:10998059 + pubmed:17009926 - a(CHEBI:alsterpaullone) decreases p(HGNC:MAPT, pmod(Ph)) + p(HGNC:CHRNA7, pmod(go:0006468 ! "protein phosphorylation")) decreases act(p(HGNC:CHRNA7)) - pmid:10998059 + pubmed:19293145 - a(CHEBI:alsterpaullone) decreases act(p(MGI:Cdk5), ma(kin)) + a(CHEBI:estradiol) decreases act(a(CHEBI:amyloid-beta)) - - - pmid:10998059 - - a(CHEBI:alsterpaullone) decreases act(p(MGI:Cdk5r1)) - - - - - pmid:10998059 - - a(CHEBI:alsterpaullone) decreases p(MGI:Ppp1r1b, pmod(Ph)) - + - pmid:11013232 + pubmed:19293145 - a(HBP:indirubin) decreases act(p(HGNC:GSK3B), ma(kin)) + act(p(RGD:Chrna7)) regulates act(a(CHEBI:nicotine)) - pmid:10998059 + pubmed:19293145 - act(p(MGI:Cdk5), ma(kin)) increases p(MGI:Ppp1r1b, pmod(Ph)) + act(p(RGD:Chrna7)) decreases act(a(CHEBI:"glutamate(2-)")) - - - pmid:24808823 - - p(MGI:Cdk5) negativeCorrelation path(MESH:"Spatial Learning") - - - pmid:24808823 + pubmed:19293145 - act(p(MGI:Cdk5)) positiveCorrelation p(MGI:Ttbk1) + composite(p(HGNC:JAK2), p(HGNC:STAT3)) regulates act(p(HGNC:INS)) - pmid:27087442 + pubmed:19293145 - p(MGI:Cdk5) decreases p(MGI:Cdk5r1) + act(p(HGNC:INS)) association path(MESH:"Alzheimer Disease") - pmid:27087442 + pubmed:30606258 - p(MGI:Cdk5) decreases act(p(HBP:RAC1b)) + p(HGNC:INS) increases p(HGNC:AKT1, pmod(go:0006468 ! "protein phosphorylation")) - pmid:27087442 + pubmed:30606258 - p(MGI:Cdk5) decreases path(MESH:Cognition) + p(HGNC:INS) decreases p(HGNC:GSK3A, pmod(go:0006468 ! "protein phosphorylation")) - pmid:27087442 + pubmed:30606258 - p(MGI:Cdk5) increases bp(GO:"neuron death") + p(HGNC:INS) decreases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation")) - pmid:14642273 + pubmed:30606258 - act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 175)) + act(p(HGNC:INS)) negativeCorrelation p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) - pmid:14642273 + pubmed:30606258 - act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 176)) + act(p(HGNC:INS)) negativeCorrelation p(HGNCGENEFAMILY:"MTOR complex 1") - pmid:14642273 + pubmed:30606258 - act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 178)) + act(p(HGNC:INS)) negativeCorrelation act(p(HGNC:RPS6KB1)) - pmid:14642273 + pubmed:26195256 - act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 195)) + p(HGNC:INS) increases a(CHEBI:amyloid-beta) - pmid:14642273 + pubmed:19293145 - act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 198)) + g(HGNC:NIN) association g(HGNC:GSK3B) - pmid:14642273 + pubmed:19293145 - act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 199)) + g(HGNC:GSK3B) association g(HGNC:NIN) - pmid:14642273 + pubmed:19293145 - act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 202)) + act(p(HGNC:MYC)) increases bp(GO:"apoptotic process") - - - pmid:14642273 - - act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 205)) - - - pmid:14642273 + pubmed:23454242 - act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 217)) + p(HGNC:MYC) decreases act(p(FPLX:PPP2C)) - pmid:14642273 + pubmed:19293145 - act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 220)) + complex(a(CHEBI:nicotine), p(HGNC:CHRNA7)) increases bp(GO:"ERK1 and ERK2 cascade") - pmid:14642273 + pubmed:19293145 - act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 235)) + complex(a(CHEBI:nicotine), p(HGNC:CHRNA7)) increases act(p(FPLX:JNK)) - pmid:14642273 + pubmed:19293145 - act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 239)) + complex(a(CHEBI:nicotine), p(HGNC:CHRNA7)) increases bp(GO:"MAPK cascade") - pmid:14642273 + pubmed:29428175 - act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 396)) + complex(a(CHEBI:nicotine), p(HGNC:CHRNA7)) increases bp(GO:"activation of phospholipase C activity") - pmid:14642273 + pubmed:29428175 - act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 400)) + complex(a(CHEBI:nicotine), p(HGNC:CHRNA7)) increases act(p(HGNC:CHRNA7)) - pmid:14642273 + pubmed:19293145 - act(p(MGI:Cdk5), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 403)) + a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases p(HGNC:MAPK1, pmod(go:0006468 ! "protein phosphorylation")) - - - pmid:8702879 + pubmed:19293145 - p(HGNC:SYN1, pmod(Ph, Ser, 551)) negativeCorrelation act(p(HGNC:SYN1)) + a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases p(HGNC:MAPK3, pmod(go:0006468 ! "protein phosphorylation")) - - - pmid:8702879 + pubmed:19293145 - act(p(HGNC:SYN1)) negativeCorrelation p(HGNC:SYN1, pmod(Ph, Ser, 551)) + a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") causesNoChange p(HGNC:MAPK14, pmod(go:0006468 ! "protein phosphorylation")) - - - - - pmid:8702879 + pubmed:19293145 - act(p(HGNC:SYN1)) negativeCorrelation p(HGNC:SYN1, pmod(Ph, Ser, 62)) + a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") causesNoChange p(HGNC:MAPK8, pmod(go:0006468 ! "protein phosphorylation")) - - - pmid:8702879 + pubmed:19721446 - act(p(HGNC:SYN1)) negativeCorrelation p(HGNC:SYN1, pmod(Ph, Ser, 67)) + a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases bp(GO:cognition) - pmid:8702879 + pubmed:19721446 - act(p(HGNC:SYN1)) increases bp(GO:"actin filament bundle assembly") + a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases path(MESH:"Memory, Episodic") - - - pmid:8702879 + pubmed:19721446 - p(HGNC:SYN1, pmod(Ph, Ser, 62)) negativeCorrelation act(p(HGNC:SYN1)) + a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases bp(MESH:Neuroprotection) - pmid:8702879 + pubmed:19721446 - p(HGNC:SYN1, pmod(Ph, Ser, 67)) negativeCorrelation act(p(HGNC:SYN1)) + a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") decreases act(a(CHEBI:"amyloid-beta polypeptide 42")) - - - - - - - pmid:26400044 + pubmed:19721446 - p(MGI:Wasf1, pmod(Ph)) partOf complex(p(HBP:"Tau aggregates"), p(MGI:Dpysl2, pmod(Ph)), p(MGI:Wasf1, pmod(Ph))) + a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") decreases bp(MESH:"Cell Survival") - pmid:26400044 + pubmed:19721446 - p(MGI:Wasf1, pmod(Ph)) partOf complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt, pmod(HBP:hyperphosphorylation)), p(MGI:Wasf1, pmod(Ph))) + a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases bp(MESH:"Sensory Gating") - - - - - - - - - - - - - - - pmid:26400044 + pubmed:19721446 - complex(p(MGI:Dpysl2, pmod(Ph)), p(MGI:Mapt, pmod(Ph)), p(MGI:Wasf1, pmod(Ph))) association path(MESH:"Plaque, Amyloid") + a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases bp(MESH:"Sensory Gating") - pmid:8726973 + pubmed:19721446 - a(HBP:isopentanyladenine) decreases act(p(HGNC:CDK5)) + a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases act(p(HGNC:CHRNA7)) - pmid:8726973 + pubmed:19721446 - a(HBP:olomoucine) decreases act(p(HGNC:CDK5)) + a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases bp(GO:memory) - pmid:18239272 + pubmed:19721446 - p(HGNC:CSNK1D) increases p(HGNC:MAPT, pmod(Ph)) + a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases path(MESH:Attention) - - - pmid:25673844 - - p(HGNC:CSNK1D) isA p(FPLX:CSNK1) - + - - - pmid:23088643 - - p(HGNC:TTBK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 198)) - + - pmid:23088643 + pubmed:22530628 - p(HGNC:TTBK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 199)) + p(HGNC:MAPK3) increases bp(MESH:"Neuronal Plasticity") - pmid:23088643 + pubmed:22530628 - p(HGNC:TTBK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) + p(HGNC:MAPK3) increases bp(GO:cognition) - pmid:23088643 + pubmed:22530628 - p(HGNC:TTBK1) increases p(HGNC:MAPT, pmod(Ph, Tyr, 197)) + p(HGNC:MAPK3) increases bp(GO:"learning or memory") - pmid:23687953 + pubmed:22530628 - act(p(HGNC:TTBK1), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Tyr, 197)) + act(p(HGNC:MAPK3)) increases p(HGNC:ARC) - pmid:23088643 + pubmed:22530628 - p(HGNC:TTBK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 422)) + p(HGNC:MAPK3) increases p(HGNC:ARC) - - - pmid:23088643 - - p(HGNC:TTBK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 422)) - - - - - pmid:23088643 - - p(HGNC:TTBK1) association a(HBP:pretangles) - + - pmid:23088643 + pubmed:23528736 - p(HGNC:TTBK1) association a(HBP:"Tau fibrils") + p(HGNC:MAPK8) increases bp(GO:autophagy) - pmid:20096481 + pubmed:23528736 - p(HGNC:TTBK1) increases act(p(HGNC:CDK5)) + p(HGNC:MAPK8) increases p(HGNC:BCL2, pmod(go:0006468 ! "protein phosphorylation")) - pmid:20096481 + pubmed:23528736 - p(HGNC:TTBK1) increases act(p(HGNC:GSK3B), ma(kin)) + p(HGNC:MAPK8) increases p(HGNC:BCL2L11, pmod(go:0006468 ! "protein phosphorylation")) - pmid:25673844 + pubmed:11943212 - p(HGNC:TTBK1) isA p(HBP:"CK1 superfamily") + p(HGNC:MAPK8) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 181)) - pmid:25673844 + pubmed:19293145 - p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 42)) + a(MESH:A-582941) increases p(HGNC:MAPK3, pmod(go:0006468 ! "protein phosphorylation")) - pmid:25673844 + pubmed:19293145 - p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 45)) + a(MESH:A-582941) increases p(HGNC:MAPK1, pmod(go:0006468 ! "protein phosphorylation")) - pmid:25673844 + pubmed:19293145 - p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 47)) + a(CHEBI:SL-327) decreases act(a(MESH:A-582941)) - pmid:25673844 + pubmed:19293145 - p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 80)) + composite(a(CHEBI:amyloid-beta), p(HGNC:CHRNA7)) increases bp(GO:"MAPK cascade") - pmid:25673844 + pubmed:19293145 - p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Ser, 81)) + composite(a(CHEBI:amyloid-beta), p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)") - pmid:25673844 + pubmed:19293145 - p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(Ph, Thr, 84)) + composite(a(CHEBI:amyloid-beta), p(HGNC:CHRNA7)) increases act(p(HGNC:MAPK1)) - pmid:25473830 + pubmed:19293145 - p(HGNC:TTBK1) directlyIncreases p(HGNC:TARDBP, pmod(Ph)) + composite(a(CHEBI:amyloid-beta), p(HGNC:CHRNA7)) increases p(FPLX:AKT, pmod(go:0006468 ! "protein phosphorylation")) - pmid:25473830 + pubmed:19293145 - p(HGNC:TTBK1) increases tloc(p(HGNC:TARDBP, pmod(Ph)), fromLoc(GO:nucleus), toLoc(GO:cytoplasm)) + composite(a(CHEBI:amyloid-beta), p(HGNC:CHRNA7)) increases tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:20096481 + pubmed:19293145 - g(DBSNP:rs2651206) positiveCorrelation path(MESH:"Alzheimer Disease") + composite(p(FPLX:ERK), p(FPLX:RAF), p(FPLX:RAS), p(HGNC:MAP2K1)) increases act(a(CHEBI:nicotine)) - pmid:21548880 + pubmed:19293145 - g(DBSNP:rs2651206) positiveCorrelation path(MESH:"Alzheimer Disease") + composite(p(FPLX:JAK), p(HGNC:STAT3)) increases p(HGNC:STAT3, pmod(go:0006468 ! "protein phosphorylation")) - - - pmid:20096481 - - g(DBSNP:rs2651206) association g(HGNC:TTBK1) - - - pmid:21548880 + pubmed:19293145 - g(DBSNP:rs2651206) isA g(HGNC:TTBK1) + act(a(CHEBI:"N-methyl-D-aspartic acid")) increases path(CONSO:neurotoxicity) - pmid:20096481 + pubmed:19293145 - g(DBSNP:rs10807287) positiveCorrelation path(MESH:"Alzheimer Disease") + a(MESH:"3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole") increases act(p(RGD:Chrna7)) - pmid:20096481 + pubmed:19721446 - g(DBSNP:rs10807287) association g(HGNC:TTBK1) + a(MESH:"3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole") association path(MESH:"Attention Deficit Disorder with Hyperactivity") - pmid:20096481 + pubmed:19293145 - g(DBSNP:rs7764257) positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:"calcium(1+)") decreases act(a(MESH:"3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole")) - pmid:20096481 + pubmed:19293145 - g(DBSNP:rs7764257) association g(HGNC:TTBK1) + p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors") association a(CHEBI:nicotine) - pmid:20096481 + pubmed:19293145 - g(HGNC:TTBK1) association g(DBSNP:rs2651206) + act(p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors")) association a(CHEBI:"calcium(2+)") - - - pmid:20096481 - - g(HGNC:TTBK1) association g(DBSNP:rs10807287) - - - pmid:20096481 + pubmed:26979166 - g(HGNC:TTBK1) association g(DBSNP:rs7764257) + p(HGNCGENEFAMILY:"Inositol 1,4,5-triphosphate receptors") increases tloc(a(CHEBI:"calcium ion"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:2820993 + pubmed:19293145 - act(p(FPLX:CSNK2)) increases act(p(HGNC:GSK3B), ma(kin)) + p(HGNCGENEFAMILY:"Ryanodine receptors") association a(CHEBI:nicotine) - pmid:21548880 + pubmed:19293145 - p(HGNC:TTBK2, var("p.Tyr448*")) positiveCorrelation path(HBP:"Spinocerebellar Ataxia 11") + act(p(HGNCGENEFAMILY:"Ryanodine receptors")) increases bp(GO:"cellular calcium ion homeostasis") - pmid:21548880 + pubmed:29428175 - p(HGNC:TTBK2, var("p.Tyr448*")) increases p(HGNC:TTBK2) + p(HGNCGENEFAMILY:"Ryanodine receptors") increases a(CHEBI:"calcium ion", loc(MESH:"Intracellular Space")) - pmid:21548880 + pubmed:26979166 - p(HGNC:TTBK2, var("p.Tyr448*")) decreases act(p(HGNC:TTBK2), ma(kin)) + p(HGNCGENEFAMILY:"Ryanodine receptors") increases tloc(a(CHEBI:"calcium ion"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:21548880 + pubmed:19293145 - path(HBP:"Spinocerebellar Ataxia 11") positiveCorrelation p(HGNC:TTBK2, var("p.Tyr448*")) + composite(a(CHEBI:"calcium(2+)"), a(MESH:Calcineurin), p(HGNC:PTPN5)) increases p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits", pmod(go:0006468 ! "protein phosphorylation")) - - - pmid:21548880 - - path(HBP:"Spinocerebellar Ataxia 11") positiveCorrelation p(HGNC:TTBK2, var("p.Asp449*")) - - - pmid:21548880 + pubmed:27013968 - path(HBP:"Spinocerebellar Ataxia 11") positiveCorrelation p(HGNC:TTBK2, var("p.Glu450*")) + p(HGNC:PTPN5) negativeCorrelation p(HGNC:HTT, pmod(HBP:"CAG repeats")) - pmid:21548880 + pubmed:19293145 - p(HGNC:TTBK2, var("p.Asp449*")) positiveCorrelation path(HBP:"Spinocerebellar Ataxia 11") + bp(GO:"regulation of cytosolic calcium ion concentration") association path(MESH:"Alzheimer Disease") - pmid:21548880 + pubmed:19293145 - p(HGNC:TTBK2, var("p.Asp449*")) increases p(HGNC:TTBK2) + composite(a(CHEBI:amyloid-beta), complex(p(HGNC:CHRNA3), p(HGNC:CHRNB2)), p(HGNC:CHRNA7)) increases bp(GO:"cellular calcium ion homeostasis") - - - pmid:21548880 - - p(HGNC:TTBK2, var("p.Asp449*")) decreases act(p(HGNC:TTBK2), ma(kin)) - - - pmid:21548880 + pubmed:19293145 - p(HGNC:TTBK2, var("p.Glu450*")) positiveCorrelation path(HBP:"Spinocerebellar Ataxia 11") + composite(p(HGNC:JAK2), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) association bp(GO:"calcium-mediated signaling") - pmid:21548880 + pubmed:19293145 - p(HGNC:TTBK2, var("p.Glu450*")) increases p(HGNC:TTBK2) + composite(p(HGNC:MAPK14), p(HGNC:MAPK8)) decreases bp(GO:"long-term synaptic potentiation") - pmid:21548880 + pubmed:19293145 - p(HGNC:TTBK2, var("p.Glu450*")) decreases act(p(HGNC:TTBK2), ma(kin)) + p(HGNC:CHRNA7, var("p.Trp55Ala")) decreases complex(p(HGNC:APOE), p(HGNC:CHRNA7)) - pmid:19118186 + pubmed:19293145 - p(MGI:Ttbk1) increases p(MGI:Cdk5r1) + act(a(CHEBI:carbachol)) increases act(a(CHEBI:phosphatidylinositol), ma(MESH:Hydrolysis)) - pmid:19118186 + pubmed:24590577 - p(MGI:Ttbk1) positiveCorrelation act(p(ECCODE:"3.4.22.52")) + a(CHEBI:carbachol) increases act(p(HGNC:CHRM1)) - pmid:19118186 + pubmed:26751493 - p(MGI:Ttbk1) negativeCorrelation p(MGI:Grin2b) + a(CHEBI:phosphatidylinositol) association p(CONSO:"projection domain") - - - pmid:19118186 - - p(MGI:Ttbk1) negativeCorrelation p(MGI:Grin2d) - - - pmid:19118186 + pubmed:19293145 - p(MGI:Ttbk1) negativeCorrelation p(MGI:Capn1) + complex(a(CHEBI:amyloid-beta), g(CONSO:"APOE e4")) decreases act(a(CHEBI:carbachol)) - pmid:24808823 + pubmed:19293145 - p(MGI:Ttbk1) negativeCorrelation path(MESH:"Spatial Learning") + a(CHEBI:wortmannin) decreases act(a(CHEBI:estrogen)) - pmid:24808823 + pubmed:30145931 - p(MGI:Ttbk1) increases a(HBP:pretangles) + a(CHEBI:wortmannin) decreases bp(GO:autophagy) - pmid:24808823 + pubmed:30145931 - p(MGI:Ttbk1) increases deg(a(MESH:"Motor Neurons")) + a(CHEBI:wortmannin) increases p(HGNC:MAPT) - pmid:24808823 + pubmed:30145931 - p(MGI:Ttbk1) increases bp(GO:"neuroinflammatory response") + a(CHEBI:wortmannin) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262), pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) - pmid:24808823 + pubmed:30145931 - p(MGI:Ttbk1) positiveCorrelation act(p(MGI:Cdk5)) + a(CHEBI:wortmannin) causesNoChange p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) - - - pmid:19118186 - - act(p(ECCODE:"3.4.22.52")) positiveCorrelation p(MGI:Ttbk1) - - - pmid:19118186 + pubmed:19293145 - p(MGI:Grin2b) negativeCorrelation p(MGI:Ttbk1) + composite(a(CHEBI:nicotine), complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) decreases tloc(a(CHEBI:amyloid-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:24808823 + pubmed:19293145 - surf(p(MGI:Grin2b)) positiveCorrelation path(MESH:"Spatial Learning") + composite(a(CHEBI:nicotine), complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) causesNoChange r(HGNC:APP) - - - pmid:19118186 + pubmed:19293145 - p(MGI:Grin2d) negativeCorrelation p(MGI:Ttbk1) + complex(a(CHEBI:amyloid-beta), p(HGNC:CHRNA7)) increases path(CONSO:neurotoxicity) - - - - - pmid:19118186 + pubmed:19293145 - complex(p(MGI:Cdk5), p(MGI:Cdk5r1)) negativeCorrelation complex(a(GO:"filamentous actin"), p(MGI:Cdk5r1)) + complex(a(CHEBI:amyloid-beta), p(HGNC:CHRNA7)) decreases complex(a(MESH:Bungarotoxins), p(HGNC:CHRNA7)) - pmid:19118186 + pubmed:22530628 - complex(p(MGI:Cdk5), p(MGI:Cdk5r1)) negativeCorrelation complex(GO:"filamentous actin") + complex(a(CHEBI:amyloid-beta), p(HGNC:CHRNA7)) increases p(HGNC:CHRNA7) - - - - - pmid:19118186 + pubmed:22530628 - complex(a(GO:"filamentous actin"), p(MGI:Cdk5r1)) negativeCorrelation complex(p(MGI:Cdk5), p(MGI:Cdk5r1)) + complex(a(CHEBI:amyloid-beta), p(HGNC:CHRNA7)) decreases p(HGNC:CHRNA7) - pmid:25673844 + pubmed:26979166 - p(HGNC:VRK2) isA p(HBP:"CK1 superfamily") + complex(a(CHEBI:amyloid-beta), p(HGNC:CHRNA7)) decreases act(p(HGNC:CHRNA7)) - pmid:25673844 + pubmed:22040696 - p(HGNC:VRK3) isA p(HBP:"CK1 superfamily") + complex(a(CHEBI:amyloid-beta), p(HGNC:CHRNA7)) decreases act(p(HGNC:CHRNA7)) - pmid:25673844 + pubmed:18986241 - p(HGNC:CSNK1A1L) isA p(FPLX:CSNK1) + complex(a(CHEBI:amyloid-beta), p(HGNC:CHRNA7)) increases r(HGNC:CHRNA7) - pmid:25673844 + pubmed:18986241 - p(HGNC:CSNK1E) isA p(FPLX:CSNK1) + complex(a(CHEBI:amyloid-beta), p(HGNC:CHRNA7)) decreases bp(GO:"synaptic transmission, cholinergic") - pmid:25673844 + pubmed:22040696 - p(HGNC:CSNK1G1) isA p(FPLX:CSNK1) + complex(a(CHEBI:amyloid-beta), p(HGNC:CHRNA7)) increases bp(GO:"neuron death") - pmid:25673844 + pubmed:19293145 - p(HGNC:CSNK1G2) isA p(FPLX:CSNK1) + composite(p(HGNC:MAPK1), p(HGNC:MAPK3)) association bp(GO:memory) - pmid:25673844 + pubmed:19293145 - p(HGNC:CSNK1G3) isA p(FPLX:CSNK1) + composite(p(FPLX:ERK), p(HGNC:CHRNA7)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - - - - - - - - - - - - - - - pmid:25673844 + pubmed:19293145 - p(HGNC:SV2A, pmod(Ph, Thr, 84)) increases complex(p(HGNC:SV2A), p(HGNC:SYT1)) + composite(p(FPLX:JNK), p(HGNC:CHRNA7)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - - - - - - - pmid:27607061 + pubmed:19293145 - surf(p(HGNC:GRIK2)) positiveCorrelation act(p(HGNC:GRIK2)) + complex(p(FPLX:AKT), p(HGNC:BAD)) regulates bp(GO:"apoptotic process") - pmid:27607061 + pubmed:19293145 - act(p(HGNC:GRIK2)) positiveCorrelation surf(p(HGNC:GRIK2)) + bp(GO:"insulin receptor signaling pathway") association p(FPLX:AKT) - pmid:27607061 + pubmed:24653673 - surf(p(HGNC:GRIK2)) negativeCorrelation act(p(HGNC:RAB5A)) + bp(GO:"insulin receptor signaling pathway") increases p(HGNC:PPP2CA, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) - pmid:27607061 + pubmed:24653673 - surf(p(HGNC:GRIK2)) negativeCorrelation path(HBP:Excitotoxicity) + bp(GO:"insulin receptor signaling pathway") increases p(HGNC:PPP2CB, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) - - - - - pmid:26323690 + pubmed:27299292 - complex(p(HGNC:MAPRE1), p(HGNC:TTBK2)) increases p(HGNC:KIF2A, pmod(Ph)) + bp(GO:"insulin receptor signaling pathway") association p(HGNC:PPARGC1A) - pmid:25297623 + pubmed:29191965 - p(HGNC:MAPRE1) association p(HGNC:TTBK2) + bp(GO:"insulin receptor signaling pathway") association a(CHEBI:ethosuximide) - pmid:25297623 + pubmed:19293145 - p(HGNC:MAPRE1) partOf complex(p(HGNC:MAPRE1), p(HGNC:TTBK2)) + bp(GO:"choline transport") association a(CHEBI:amyloid-beta) - pmid:26323690 + pubmed:19293145 - p(HGNC:KIF2A, pmod(Ph)) negativeCorrelation bp(GO:"microtubule depolymerization") + complex(a(MESH:Bungarotoxins), p(HGNC:CHRNA7)) decreases complex(a(CHEBI:amyloid-beta), p(HGNC:CHRNA7)) - - - - - - - pmid:26323690 + pubmed:19293145 - complex(p(HGNC:MAPRE3), p(HGNC:TTBK2)) increases p(HGNC:KIF2A, pmod(Ph)) + complex(a(MESH:Bungarotoxins), p(HGNC:CHRNA7)) decreases complex(a(CHEBI:amyloid-beta), p(HGNC:CHRNA7)) - pmid:22814243 + pubmed:19293145 - act(p(HGNC:SLC5A1)) positiveCorrelation bp(GO:"glucose transmembrane transport") + complex(a(MESH:Bungarotoxins), p(HGNC:CHRNA7)) decreases complex(a(CHEBI:methyllycaconitine), p(HGNC:CHRNA7)) - - - pmid:22814243 - - bp(GO:"glucose transmembrane transport") positiveCorrelation act(p(HGNC:SLC5A1)) - - - pmid:25297623 + pubmed:27190210 - p(HGNC:CEP164) association p(HGNC:TTBK2) + a(CHEBI:methyllycaconitine) decreases p(HGNC:CHRNA7) - pmid:25297623 + pubmed:25514383 - p(HGNC:CEP164) increases p(HGNC:TTBK2, loc(GO:centriole)) + a(CHEBI:methyllycaconitine) decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) - - - pmid:25297623 + pubmed:25514383 - p(HGNC:CEP164) partOf complex(p(HGNC:CEP164), p(HGNC:DVL3)) + a(CHEBI:methyllycaconitine) decreases bp(HP:Neurodegeneration) - pmid:25297623 + pubmed:19293145 - p(HGNC:CEP164) partOf complex(p(HGNC:CEP164), p(HGNC:TTBK2)) + p(HGNC:APP, frag("25_35")) increases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - - - - - pmid:25297623 + pubmed:19293145 - complex(p(HGNC:CEP164), p(HGNC:TTBK2)) increases act(p(HGNC:TTBK2)) + p(HGNC:APP, frag("25_35")) increases act(p(HGNC:CHRNA7)) - pmid:25297623 + pubmed:19721446 - p(HGNC:CEP164, pmod(Ph)) negativeCorrelation complex(p(HGNC:CEP164), p(HGNC:DVL3)) + complex(p(HGNC:CHRNA4), p(HGNC:CHRNA5), p(HGNC:CHRNB2)) association a(MESH:"Dopaminergic Neurons") - - - - - - - pmid:25297623 + pubmed:26979166 - complex(p(HGNC:CEP164), p(HGNC:DVL3)) negativeCorrelation p(HGNC:CEP164, pmod(Ph)) + p(HGNC:CHRNA7, var("?")) positiveCorrelation path(DOID:schizophrenia) - pmid:25297623 + pubmed:21482353 - p(HGNC:DVL3) partOf complex(p(HGNC:CEP164), p(HGNC:DVL3)) + p(HGNC:CHRNA7, var("?")) positiveCorrelation path(MESH:Schizophrenia) - pmid:25297623 + pubmed:19293145 - p(HGNC:DVL3) regulates bp(GO:"cytosolic ciliogenesis") + p(HGNC:MAPT, var("p.Lys595Asp")) increases path(HP:Neurodegeneration) - pmid:11943212 + pubmed:19293145 - p(HGNC:MAPK11) increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) + p(HGNC:MAPT, var("p.Met596Leu")) increases path(HP:Neurodegeneration) - pmid:11943212 + pubmed:19293145 - p(HGNC:MAPK11) increases p(HGNC:MAPT, pmod(Ph, Ser, 422)) + composite(a(CHEBI:amyloid-beta), p(MGI:Ache)) increases r(MGI:Chrna7) - pmid:11943212 + pubmed:19293145 - p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) + composite(a(CHEBI:amyloid-beta), p(MGI:Ache)) causesNoChange r(MGI:Chrna4) + + - pmid:11943212 + pubmed:23038257 - p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(Ph, Thr, 205)) + a(CHEBI:"4-(trimethylammonium)benzenediazonium") decreases act(a(MESH:"Electric Organ")) - pmid:11943212 + pubmed:23038257 - p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) + a(MESH:Curare) decreases act(a(CHEBI:"4-(trimethylammonium)benzenediazonium")) - pmid:11943212 + pubmed:23038257 - p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(Ph, Thr, 396)) + a(MESH:Curare) increases act(a(MESH:"Receptors, Nicotinic")) - pmid:11943212 + pubmed:23038257 - p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + a(CHEBI:"4-(N-Maleimido)phenyltrimethylammonium iodide") increases act(a(MESH:"Affinity Labels")) - pmid:11943212 + pubmed:23038257 - p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(Ph, Ser, 422)) + a(CHEBI:decamethonium) decreases act(a(MESH:"Receptors, Nicotinic")) - pmid:11943212 + pubmed:26813123 - p(HGNC:MAPT, pmod(Ph, Thr, 396)) partOf p(HBP:"Tau epitope, AD2") + a(MESH:"Receptors, Nicotinic") increases act(a(MESH:"Hypothalamo-Hypophyseal System")) - - - - - pmid:26751493 + pubmed:26813123 - complex(p(HBP:"projection domain"), p(HGNC:LCK)) association bp(GO:"cell-cell signaling") + act(a(MESH:"Receptors, Nicotinic")) increases bp(MESH:"Synaptic Transmission") - - - - - pmid:26751493 + pubmed:26813123 - complex(p(HBP:"projection domain"), p(HGNC:FGR)) association bp(GO:"cell-cell signaling") + a(MESH:"Receptors, Nicotinic") regulates tloc(a(CHEBI:neurotransmitter), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) - - - - - pmid:26751493 + pubmed:26813123 - complex(p(HBP:"projection domain"), p(HGNC:SRC)) association bp(GO:"cell-cell signaling") + act(a(MESH:"Receptors, Nicotinic")) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(GO:"extracellular region"), toLoc(GO:synapse)) - - - - - pmid:26751493 + pubmed:26813123 - complex(p(HBP:"projection domain"), p(HGNC:GRB2)) association bp(GO:"cell-cell signaling") + act(a(MESH:"Receptors, Nicotinic")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - - - - - pmid:26751493 + pubmed:19721446 - complex(p(FPLX:PLC), p(HBP:"projection domain")) association bp(GO:"cell-cell signaling") + a(MESH:"Receptors, Nicotinic") regulates tloc(a(CHEBI:serotonin), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - - - - - pmid:26751493 + pubmed:23038257 - complex(a(CHEBI:phosphatidylinositol), p(HBP:"projection domain")) association bp(GO:"cell-cell signaling") + a(MESH:"Gallamine Triethiodide") decreases act(a(MESH:"Receptors, Nicotinic")) @@ -157391,9 +158633,9 @@

Statements

- pmid:26751493 + pubmed:28901280 - complex(a(CHEBI:"phosphatidylinositol bisphosphate"), p(HBP:"projection domain")) association bp(GO:"cell-cell signaling") + p(MESH:"Receptors, Nicotinic") isA p(MESH:"Cysteine Loop Ligand-Gated Ion Channel Receptors") @@ -157402,338 +158644,307 @@

Statements

- - - pmid:26751493 - - complex(p(HBP:"projection domain"), p(HGNC:PIN1)) association bp(GO:"cell-cell signaling") - + - pmid:26751493 + pubmed:28901280 - p(INTERPRO:"Syntaxin, N-terminal domain") negativeCorrelation a(GO:"neurofibrillary tangle") + p(MESH:"Receptors, Nicotinic") association path(MESH:Learning) - pmid:11943212 + pubmed:28901280 - p(HGNC:MARK4, pmod(Ph)) association p(HGNC:MAPT, pmod(Ph, Ser, 262)) + p(MESH:"Receptors, Nicotinic") association path(MESH:Memory) - - - pmid:22692785 + pubmed:28901280 - p(HGNC:MARK4) negativeCorrelation p(HBP:PrPSc) + p(MESH:"Receptors, Nicotinic") association path(MESH:Arousal) - pmid:22156579 + pubmed:28901280 - p(HGNC:MARK4) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + p(MESH:"Receptors, Nicotinic") association path(MESH:Reward) - pmid:23666762 + pubmed:28901280 - p(HGNC:MARK4) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + p(MESH:"Receptors, Nicotinic") association path(MESH:"Motor Activity") - pmid:27708431 + pubmed:28901280 - p(HGNC:MARK4) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + p(MESH:"Receptors, Nicotinic") association bp(MESH:Analgesia) - pmid:22156579 + pubmed:28901280 - p(HGNC:MARK4) increases p(HGNC:MAPT, pmod(Ph, Ser, 356)) + p(MESH:"Receptors, Nicotinic") association bp(GO:"depolarization of postsynaptic membrane") - pmid:23666762 + pubmed:28901280 - p(HGNC:MARK4) positiveCorrelation path(MESH:"Alzheimer Disease") + p(MESH:"Receptors, Nicotinic") association bp(GO:"action potential initiation") - pmid:22156579 + pubmed:28901280 - p(HGNC:MARK4) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + p(MESH:"Receptors, Nicotinic") association bp(GO:"cell proliferation") - pmid:22156579 + pubmed:28901280 - p(HGNC:MARK4) negativeCorrelation act(p(RGD:Dlg4)) + p(MESH:"Receptors, Nicotinic") association bp(GO:"cell differentiation") - pmid:22156579 + pubmed:28901280 - p(HGNC:MARK4) negativeCorrelation p(RGD:Gria1) + p(MESH:"Receptors, Nicotinic") association path(MESH:"Cognition Disorders") - pmid:22156579 + pubmed:28901280 - p(HGNC:MARK4) negativeCorrelation a(GO:"dendritic spine") + p(MESH:"Receptors, Nicotinic") association path(MESH:Anxiety) - pmid:22156579 + pubmed:28901280 - p(HGNC:MARK4) negativeCorrelation a(GO:synapse) + p(MESH:"Receptors, Nicotinic") association path(MESH:Depression) - - - - - pmid:11943212 + pubmed:28901280 - complex(p(HGNC:MAPT, pmod(Ph, Ser, 262)), p(HGNC:MARK4, pmod(Ph))) association path(HBP:"granulovacuolar degeneration") + p(MESH:"Receptors, Nicotinic") association path(MESH:"Alzheimer Disease") - pmid:22692785 + pubmed:28901280 - p(HBP:PrPSc) negativeCorrelation p(HGNC:MARK4) + p(MESH:"Receptors, Nicotinic") association path(MESH:"Parkinson Disease") - pmid:22692785 + pubmed:28901280 - p(HBP:"PrP106-126") decreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + p(MESH:"Receptors, Nicotinic") association path(MESH:Pain) - pmid:16973293 + pubmed:28901280 - p(HBP:"MARK4 isoform 2 (688 aa)") positiveCorrelation bp(GO:"neuron development") + p(MESH:"Receptors, Nicotinic") association path(MESH:Epilepsy) - pmid:16973293 + pubmed:28901280 - p(HBP:"MARK4 isoform 2 (688 aa)") isA p(HGNC:MARK4) + p(MESH:"Receptors, Nicotinic") association a(MESH:Neurons) - - - - - - - - - - - - - pmid:23666762 + pubmed:28901280 - complex(p(HGNC:MAPT), p(HGNC:MARK1)) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + p(MESH:"Receptors, Nicotinic") positiveCorrelation bp(UBERON:0002138) - - - - - pmid:23666762 + pubmed:23038257 - complex(p(HGNC:MAPT), p(HGNC:MARK2)) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + p(HGNC:SCNN1D) association a(CHEBI:chlorpromazine) - - - pmid:23666762 + pubmed:23038257 - complex(p(HGNC:MAPT), p(HGNC:MARK3)) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + a(CHEBI:"zinc(2+)") increases act(p(MESH:"Receptors, Nicotinic")) - - - - - pmid:23666762 + pubmed:19721446 - complex(p(HGNC:MAPT), p(HGNC:MARK4)) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + a(CHEBI:"zinc(2+)") decreases act(p(CONSO:"alpha-4 beta-2 nAChR")) - pmid:23666762 + pubmed:2833519 - complex(p(HGNC:MAPT), p(HGNC:MARK4)) positiveCorrelation path(MESH:"Alzheimer Disease") + a(CHEBI:"zinc(2+)") increases act(p(HGNC:S100B)) - pmid:23666762 + pubmed:23038257 - p(HBP:"CagA peptide") decreases act(p(HGNC:MARK4), ma(kin)) + a(MESH:Galantamine) regulates act(p(MESH:"Receptors, Nicotinic")) - pmid:23666762 + pubmed:23038257 - p(HBP:"CagA peptide") decreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + a(MESH:Ivermectin) increases act(p(HGNC:CHRNA7)) - pmid:27798139 + pubmed:23038257 - act(p(MGI:Dapk1)) increases a(GO:synapse) + p(HGNC:SCNN1D, var("?")) regulates act(a(MESH:Ivermectin)) - pmid:27798139 + pubmed:23038257 - act(p(MGI:Dapk1)) decreases path(MESH:"Spatial Learning") + a(MESH:Anesthetics) decreases p(MESH:"Receptors, Nicotinic") - pmid:27798139 + pubmed:23038257 - act(p(MGI:Dapk1)) decreases bp(GO:memory) + a(MESH:Anesthetics) increases p(MESH:"Receptors, GABA") - pmid:25995053 + pubmed:19721446 - act(p(MGI:Dapk1), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 262)) + a(MESH:Anesthetics) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:27094130 + pubmed:23038257 - p(HGNC:DAPK1) increases sec(p(HGNC:APP, frag("672_713"))) + p(MESH:Agrin) increases p(HGNC:RAPSN, pmod(go:0006468 ! "protein phosphorylation", Tyr)) - pmid:27094130 + pubmed:23038257 - act(p(HGNC:DAPK1), ma(kin)) positiveCorrelation sec(p(HGNC:APP, frag("672_713"))) + p(HGNC:RAPSN, pmod(go:0006468 ! "protein phosphorylation", Tyr)) increases act(a(MESH:"Motor Endplate"), ma(GO:localization)) + + - pmid:27094130 + pubmed:22040696 - act(p(HGNC:DAPK1), ma(kin)) increases p(HGNC:APP, pmod(Ph, Thr, 668)) + p(HGNC:RAPSN) increases bp(GO:"skeletal muscle acetylcholine-gated channel clustering") - pmid:27094130 + pubmed:23038257 - act(p(HGNC:DAPK1), ma(kin)) increases p(HGNC:APP, pmod(Ph, Thr, 668)) + p(MESH:"Receptors, Nicotinic", pmod(go:0006468 ! "protein phosphorylation")) increases act(p(MESH:Agrin)) @@ -157742,238 +158953,224 @@

Statements

- - - - - pmid:27068745 + pubmed:24511233 - act(p(HGNC:DAPK1)) increases bp(GO:"neuron apoptotic process") + p(HGNC:CHRM1) association bp(GO:cognition) - pmid:27795443 + pubmed:24511233 - act(p(HGNC:DAPK1)) negativeCorrelation act(p(HGNC:JUND)) + act(p(HGNC:CHRM1)) increases bp(GO:cognition) - pmid:27795443 + pubmed:24590577 - act(p(HGNC:DAPK1)) increases bp(GO:"apoptotic process") + act(p(HGNC:CHRM1)) increases bp(GO:cognition) - pmid:24853415 + pubmed:24511233 - p(HGNC:DAPK1) increases p(HGNC:PIN1, pmod(Ph, Ser, 71)) + p(HGNC:CHRM1) decreases act(a(CHEBI:amphetamine)) - pmid:24853415 + pubmed:24511233 - p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + p(HGNC:CHRM1) decreases bp(GO:"dopamine secretion, neurotransmission") - pmid:23948915 + pubmed:24511233 - p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + p(HGNC:CHRM1) increases act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) - pmid:21311567 + pubmed:24511233 - act(p(HGNC:DAPK1), ma(kin)) directlyIncreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + act(p(HGNC:CHRM1)) increases act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) - pmid:24853415 + pubmed:24511233 - p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + p(HGNC:CHRM1) increases bp(GO:"long-term synaptic potentiation") + + + + - pmid:23948915 + pubmed:24511233 - p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + act(p(HGNC:CHRM1)) increases a(CHEBI:acetylcholine) - pmid:24853415 + pubmed:24511233 - p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) + act(p(HGNC:CHRM1)) increases deg(p(CONSO:sAPP-alpha)) - pmid:23948915 + pubmed:24590577 - p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) + act(p(HGNC:CHRM1)) increases p(CONSO:sAPP-alpha) + + - pmid:24853415 + pubmed:26813123 - p(HGNC:DAPK1) positiveCorrelation p(HGNC:MAPT) + act(p(HGNC:CHRM1)) association a(MESH:"Cholinergic Neurons") - pmid:21311567 + pubmed:26813123 - p(HGNC:DAPK1) directlyIncreases act(p(HGNC:MARK1)) + act(p(HGNC:CHRM1)) association path(MESH:"Cognitive Dysfunction") - pmid:21311567 + pubmed:18986241 - p(HGNC:DAPK1) directlyIncreases act(p(HGNC:MARK2)) + p(HGNC:CHRM1) association path(MESH:"Cognitive Dysfunction") - pmid:21311567 + pubmed:26813123 - p(HGNC:DAPK1) decreases bp(GO:"microtubule polymerization") + act(p(HGNC:CHRM1)) association act(p(HGNC:MAPT)) - - - - - - - - - pmid:27094130 + pubmed:26813123 - p(HGNC:DAPK1, frag("637_1423")) partOf p(HGNC:DAPK1) + act(p(HGNC:CHRM1)) association act(a(CHEBI:amyloid-beta)) - - - - - pmid:27094130 + pubmed:24590577 - p(HGNC:DAPK1, frag("848_1423")) partOf p(HGNC:DAPK1) + act(p(HGNC:CHRM1)) decreases a(CHEBI:amyloid-beta) - - - - - pmid:27094130 + pubmed:26813123 - p(HGNC:DAPK1, frag("1271_1423")) equivalentTo p(INTERPRO:"Death domain") + act(p(HGNC:CHRM1)) decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) - pmid:27094130 + pubmed:26813123 - p(INTERPRO:"Death domain") equivalentTo p(HGNC:DAPK1, frag("1271_1423")) + act(p(HGNC:CHRM1)) increases act(p(FPLX:PKC)) - pmid:27094130 + pubmed:24590577 - p(INTERPRO:"Death domain") partOf p(HGNC:DAPK1) + act(p(HGNC:CHRM1)) increases act(p(FPLX:PKC)) - pmid:27068745 + pubmed:24590577 - p(HGNC:UNC5B) increases act(p(HGNC:DAPK1)) + act(p(HGNC:CHRM1)) increases act(p(FPLX:PKC)) - pmid:27068745 + pubmed:24590577 - p(HGNC:UNC5B) positiveCorrelation act(p(FPLX:PPP2), ma(phos)) + act(p(HGNC:CHRM1)) increases act(p(FPLX:PKC)) - pmid:27068745 + pubmed:26813123 - act(p(HGNC:DAPK1, pmod(Ph))) decreases act(p(HGNC:DAPK1)) + act(p(HGNC:CHRM1)) decreases act(p(HGNC:GSK3B)) - pmid:27068745 + pubmed:24590577 - p(HGNC:UNC5C) positiveCorrelation bp(GO:"neuron apoptotic process") + act(p(HGNC:CHRM1)) decreases act(p(HGNC:GSK3B)) @@ -157982,192 +159179,200 @@

Statements

- pmid:27068745 + pubmed:24590577 - p(HGNC:UNC5C, var("p.Thr835Met")) increases bp(GO:"neuron apoptotic process") + p(HGNC:CHRM1) association a(MESH:Hippocampus) - pmid:27068745 + pubmed:24590577 - p(HGNC:UNC5C, var("p.Thr835Met")) positiveCorrelation act(p(HGNC:PRKD1)) + p(HGNC:CHRM1) association a(MESH:"Cerebral Cortex") - pmid:27068745 + pubmed:24590577 - p(HGNC:CALML5) decreases bp(GO:"neuron apoptotic process") + p(HGNC:CHRM1) association a(MESH:"Corpus Striatum") - pmid:27068745 + pubmed:24590577 - act(p(HGNC:PRKD1)) positiveCorrelation p(HGNC:UNC5C, var("p.Thr835Met")) + p(HGNC:CHRM1) association a(MESH:Thalamus) - pmid:27068745 + pubmed:24590577 - act(p(HGNC:PRKD1)) positiveCorrelation act(p(HGNC:MAP3K5)) + p(HGNC:CHRM1) association bp(GO:"regulation of synaptic plasticity") - pmid:27068745 + pubmed:24590577 - act(p(HGNC:MAP3K5)) positiveCorrelation act(p(HGNC:PRKD1)) + p(HGNC:CHRM1) association bp(GO:learning) - pmid:27068745 + pubmed:24590577 - act(p(HGNC:MAP3K5)) increases act(p(FPLX:JNK)) + p(HGNC:CHRM1) association bp(GO:memory) - pmid:27068745 + pubmed:24590577 - act(p(HGNC:MAP3K5)) association p(HGNC:CASP3) + p(HGNC:CHRM1) association bp(GO:"neuronal signal transduction") - pmid:27068745 + pubmed:24590577 - p(ECCODE:"1.6.3.1") positiveCorrelation act(p(FPLX:JNK)) + p(HGNC:CHRM1) association bp(GO:"neuron differentiation") - - - - - pmid:27795443 + pubmed:24590577 - act(p(HGNC:JUND)) decreases bp(GO:"apoptotic process") + p(HGNC:CHRM1) regulates bp(GO:"synaptic transmission, glutamatergic") - pmid:27795443 + pubmed:24590577 - act(p(HGNC:JUND)) negativeCorrelation act(p(HGNC:DAPK1)) + act(p(HGNC:CHRM1)) increases bp(GO:"ERK1 and ERK2 cascade") - pmid:27795443 + pubmed:24590577 - act(p(HGNC:CSK), ma(kin)) increases p(HGNC:DAPK1, pmod(Ph)) + act(p(HGNC:CHRM1)) causesNoChange bp(GO:"ERK1 and ERK2 cascade") - pmid:27795443 + pubmed:24590577 - act(p(HGNC:CSK), ma(kin)) decreases act(p(HGNC:DAPK1)) + act(p(HGNC:CHRM1)) increases p(HGNC:BACE1) - pmid:27133022 + pubmed:24590577 - p(HBP:"DAPK, basic loop (BL) motif") partOf p(HGNC:DAPK2) + p(HGNC:CHRM1) regulates p(HGNC:BACE1) - pmid:27133022 + pubmed:24590577 - p(HBP:"DAPK, basic loop (BL) motif") positiveCorrelation act(p(HGNC:DAPK2)) + act(p(HGNC:CHRM1)) increases bp(GO:"MAPK cascade") + + - pmid:27133022 + pubmed:24590577 - p(HBP:"DAPK, basic loop (BL) motif") positiveCorrelation complex(p(FPLX:CALM), p(HGNC:DAPK2)) + act(p(HGNC:CHRM1)) decreases path(CONSO:neurotoxicity) - pmid:27133022 + pubmed:24590577 - p(HBP:"DAPK, basic loop (BL) motif") positiveCorrelation complex(a(CHEBI:"calcium(2+)"), p(HGNC:DAPK2)) + act(p(HGNC:CHRM1)) increases bp(GO:"Wnt signaling pathway") - pmid:27133022 + pubmed:24590577 - act(p(HGNC:DAPK2)) positiveCorrelation p(HBP:"DAPK, basic loop (BL) motif") + act(p(HGNC:CHRM1)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) - + + + pubmed:24590577 + + act(p(HGNC:CHRM1)) decreases path(MESH:"DNA Damage") + - pmid:27133022 + pubmed:24590577 - complex(p(FPLX:CALM), p(HGNC:DAPK2)) positiveCorrelation p(HBP:"DAPK, basic loop (BL) motif") + act(p(HGNC:CHRM1)) decreases path(MESH:"Oxidative Stress") - + + + pubmed:24590577 + + act(p(HGNC:CHRM1)) decreases act(p(HGNCGENEFAMILY:Caspases)) + - pmid:27133022 + pubmed:24590577 - complex(a(CHEBI:"calcium(2+)"), p(HGNC:DAPK2)) positiveCorrelation p(HBP:"DAPK, basic loop (BL) motif") + act(p(HGNC:CHRM1)) decreases bp(GO:"cell death") @@ -158178,252 +159383,261 @@

Statements

- pmid:25995053 + pubmed:18986241 - complex(p(MGI:Dapk1), p(MGI:Mapt)) decreases a(GO:"dendritic spine") + p(HGNC:CHRM1) association path(MESH:Tauopathies) - pmid:25995053 + pubmed:18986241 - complex(p(MGI:Dapk1), p(MGI:Mapt)) increases bp(GO:"neuron apoptotic process") + p(HGNC:CHRM1) association path(MESH:Amyloidosis) - - - pmid:24853415 - - p(HGNC:PIN1, pmod(Ph, Ser, 71)) decreases act(p(HGNC:PIN1)) - + - - - pmid:22926167 - - p(HGNC:PIN1, pmod(Ph, Ser, 71)) decreases p(HGNC:PIN1) - + - pmid:24853415 + pubmed:26813123 - p(HGNC:PIN1, pmod(Ph, Ser, 71)) positiveCorrelation p(HGNC:MAPT) + p(HGNC:CHRM2) decreases tloc(a(CHEBI:acetylcholine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) - pmid:28137862 + pubmed:26813123 - p(MGI:Dcaf1) association p(MGI:Dyrk1a) + act(p(HGNC:CHRM2)) increases a(CHEBI:amyloid-beta) + + - pmid:28137862 + pubmed:24590577 - p(MGI:Dcaf1) partOf complex(p(MGI:Dcaf1), p(MGI:Dyrk1a)) + p(HGNC:CHRM2) association a(MESH:Hippocampus) - pmid:28137862 + pubmed:24590577 - p(MGI:Dcaf1) association p(MGI:Hap1) + p(HGNC:CHRM2) association a(MESH:Neocortex) - pmid:28137862 + pubmed:24590577 - p(MGI:Dyrk1a) association p(MGI:Dcaf1) + p(HGNC:CHRM2) decreases act(a(CHEBI:dopamine)) - - - pmid:28137862 - - p(MGI:Dyrk1a) partOf complex(p(MGI:Dcaf1), p(MGI:Dyrk1a)) - + + + + + - pmid:28137862 + pubmed:24590577 - p(MGI:Dyrk1a) negativeCorrelation p(MGI:Hap1) + p(HGNC:CHRM3) association a(MESH:Hypothalamus) - pmid:29221819 + pubmed:24590577 - p(MGI:Dyrk1a) negativeCorrelation a(HBP:"granular layer of cerebellar cortex") + p(HGNC:CHRM3) association a(MESH:Hippocampus) + + + + + + - pmid:29221819 + pubmed:24511233 - p(MGI:Dyrk1a) negativeCorrelation a(HBP:"molecular layer of cerebellar cortex") + p(HGNC:CHRM4) association path(MESH:"Avoidance Learning") - pmid:29221819 + pubmed:24511233 - p(MGI:Dyrk1a) negativeCorrelation a(HBP:"Purkinje cell layer of cerebellar cortex") + p(HGNC:CHRM4) association a(MESH:Hippocampus) - pmid:29221819 + pubmed:24511233 - p(MGI:Dyrk1a) negativeCorrelation bp(GO:"dendrite arborization") + p(HGNC:CHRM4) association a(MESH:"Corpus Striatum") - pmid:29221819 + pubmed:24590577 - p(MGI:Dyrk1a) positiveCorrelation bp(GO:"cellular senescence") + p(HGNC:CHRM4) association a(MESH:"Corpus Striatum") - pmid:29221819 + pubmed:24511233 - p(MGI:Dyrk1a) positiveCorrelation path(HP:Neurodegeneration) + p(HGNC:CHRM4) association a(MESH:Neocortex) - pmid:29221819 + pubmed:24511233 - p(MGI:Dyrk1a) positiveCorrelation p(MGI:App) + p(HGNC:CHRM4) regulates bp(GO:"synaptic transmission, dopaminergic") - pmid:29221819 + pubmed:24511233 - p(MGI:Dyrk1a) positiveCorrelation a(CHEBI:"amyloid-beta") + act(p(HGNC:CHRM4)) decreases bp(GO:"synaptic transmission, glutamatergic") - pmid:29221819 + pubmed:24511233 - p(MGI:Dyrk1a) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 202)) + p(HGNC:CHRM4) regulates bp(GO:cognition) + + + + - pmid:29221819 + pubmed:24590577 - p(MGI:Dyrk1a) positiveCorrelation p(MGI:Mapt) + p(HGNC:CHRM4) association path(MESH:"Psychotic Disorders") - pmid:28540658 + pubmed:24590577 - p(MGI:Dyrk1a) decreases a(CHEBI:serotonin) + p(HGNC:CHRM4) association path(MESH:"Parkinson Disease") - pmid:28540658 + pubmed:24590577 - p(MGI:Dyrk1a) decreases a(CHEBI:dopamine) + p(HGNC:CHRM4) decreases act(p(HGNC:DRD1)) + + + + + + + + - pmid:28540658 + pubmed:24590577 - p(MGI:Dyrk1a) decreases a(CHEBI:adrenaline) + p(HGNC:CHRM5) increases bp(GO:"response to drug") - pmid:28775333 + pubmed:24590577 - p(MGI:Dyrk1a) positiveCorrelation p(HBP:"3R tau") + p(HGNC:CHRM5) increases act(a(CHEBI:morphine)) - pmid:28775333 + pubmed:24590577 - p(MGI:Dyrk1a) negativeCorrelation p(HBP:"4R tau") + p(HGNC:CHRM5) increases act(a(CHEBI:cocaine)) - pmid:28775333 + pubmed:24511233 - p(MGI:Dyrk1a) positiveCorrelation path(MESH:Anxiety) + complex(p(HGNC:CHRM1), p(HGNC:GNAQ)) increases bp(GO:"calcium ion transport") - pmid:28775333 + pubmed:24511233 - p(MGI:Dyrk1a) negativeCorrelation bp(GO:memory) + complex(p(HGNC:CHRM1), p(HGNC:GNAQ)) increases a(MESH:"Inositol 1,4,5-Trisphosphate") @@ -158432,847 +159646,871 @@

Statements

+ + + + - pmid:28137862 + pubmed:26088141 - complex(p(MGI:Dcaf1), p(MGI:Dyrk1a)) negativeCorrelation p(MGI:Hap1) + p(HGNC:GNAQ) increases complex(p(HGNC:CHRNA7), p(HGNC:GNAQ)) + + - pmid:28137862 + pubmed:24511233 - p(MGI:Hap1) association p(MGI:Dcaf1) + complex(p(HGNC:CHRM3), p(HGNC:GNAQ)) increases bp(GO:"calcium ion transport") - pmid:28137862 + pubmed:24511233 - p(MGI:Hap1) negativeCorrelation p(MGI:Dyrk1a) + complex(p(HGNC:CHRM3), p(HGNC:GNAQ)) increases a(MESH:"Inositol 1,4,5-Trisphosphate") - pmid:28137862 + pubmed:24511233 - p(MGI:Hap1) negativeCorrelation complex(p(MGI:Dcaf1), p(MGI:Dyrk1a)) + complex(p(HGNC:CHRM5), p(HGNC:GNAQ)) increases bp(GO:"calcium ion transport") - pmid:28137862 + pubmed:24511233 - p(HGNC:DYRK1A) association path(MESH:"Down Syndrome") + complex(p(HGNC:CHRM5), p(HGNC:GNAQ)) increases a(MESH:"Inositol 1,4,5-Trisphosphate") - pmid:28884684 + pubmed:24511233 - act(p(HGNC:DYRK1A), ma(kin)) positiveCorrelation bp(GO:"neuron differentiation") + complex(p(HGNC:CHRM2), p(HGNC:GNAI1)) decreases a(CHEBI:"3',5'-cyclic AMP") + + + + + + - pmid:28250274 + pubmed:26088141 - p(HGNC:DYRK1A) negativeCorrelation p(HGNC:MME) + p(HGNC:GNAI1) increases complex(p(HGNC:CHRNA7), p(HGNC:GNAI1)) - pmid:28632203 + pubmed:24511233 - p(HGNC:DYRK1A) biomarkerFor path(MESH:"Alzheimer Disease") + complex(p(HGNC:CHRM4), p(HGNC:GNAI1)) decreases a(CHEBI:"3',5'-cyclic AMP") - pmid:28167836 + pubmed:24511233 - act(p(HGNC:DYRK1A)) regulates a(HBP:Neurites) + a(MESH:"Muscarinic Antagonists") decreases bp(GO:cognition) - pmid:28167836 + pubmed:24511233 - act(p(HGNC:DYRK1A)) regulates a(GO:axon) + a(MESH:"Muscarinic Antagonists") increases path(MESH:"Cognitive Dysfunction") - - - - - pmid:29221819 + pubmed:24511233 - a(HBP:"granular layer of cerebellar cortex") negativeCorrelation p(MGI:Dyrk1a) + a(MESH:"Muscarinic Antagonists") association path(MESH:"Mental Processes") - pmid:29221819 + pubmed:24511233 - a(HBP:"molecular layer of cerebellar cortex") negativeCorrelation p(MGI:Dyrk1a) + a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") increases bp(GO:"synaptic transmission, cholinergic") - pmid:29221819 + pubmed:26813123 - a(HBP:"Purkinje cell layer of cerebellar cortex") negativeCorrelation p(MGI:Dyrk1a) + a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") increases bp(GO:"synaptic transmission, cholinergic") - pmid:29221819 + pubmed:24511233 - bp(GO:"dendrite arborization") negativeCorrelation p(MGI:Dyrk1a) + a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") increases bp(GO:cognition) - pmid:28884684 + pubmed:24511233 - a(HBP:"ID-8") decreases act(p(HGNC:DYRK1B), ma(kin)) + a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") increases path(MESH:"Mental Processes") - pmid:28884684 + pubmed:24511233 - a(HBP:"ID-8") decreases act(p(HGNC:GSK3B), ma(kin)) + a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") association a(MESH:"Cardiovascular System") - pmid:28884684 + pubmed:24511233 - a(HBP:"ID-8") decreases act(p(HGNC:DYRK1A), ma(kin)) + a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") association a(MESH:"Gastrointestinal Tract") - pmid:28884684 + pubmed:17009926 - a(HBP:"ID-8") decreases bp(GO:"neuron differentiation") + a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") decreases path(MESH:"Alzheimer Disease") - pmid:28250274 + pubmed:17009926 - a(CHEBI:harmine) decreases p(HGNC:DYRK1A) + a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") decreases act(p(HGNC:ACHE)) - pmid:28250274 + pubmed:17009926 - a(CHEBI:harmine) increases p(HGNC:MME) + a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") decreases rxn(reactants(a(CHEBI:acetylcholine)), products(a(CHEBI:acetate), a(CHEBI:choline))) - pmid:29077046 + pubmed:17009926 - a(CHEBI:harmine) increases complex(a(CHEBI:harmine), g(HGNC:DYRK1A)) + a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") increases act(p(FPLX:CHRN)) - pmid:28775333 + pubmed:24511233 - p(MGI:Mef2d) increases r(MGI:Dyrk1a) + path(MESH:"Mental Processes") association a(MESH:"Muscarinic Antagonists") - pmid:28775333 + pubmed:24511233 - p(MGI:Mef2d) increases act(p(MGI:Dyrk1a), ma(kin)) + a(MESH:"Cardiovascular System") association a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") - - - - - - - pmid:28632203 + pubmed:24590577 - composite(a(CHEBI:homocysteine), p(HGNC:BDNF), p(HGNC:DYRK1A)) biomarkerFor path(MESH:"Alzheimer Disease") + a(MESH:"Cardiovascular System") association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") - pmid:28167836 + pubmed:24511233 - p(HGNC:DYRK1A, var("p.Arg205del")) decreases act(p(HGNC:DYRK1A)) + a(MESH:"Gastrointestinal Tract") association a(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor") - pmid:28167836 + pubmed:24511233 - p(HGNC:DYRK1A, var("p.Glu239del")) decreases act(p(HGNC:DYRK1A)) + a(MESH:"Gastrointestinal Tract") association a(CHEBI:xanomeline) - + + + pubmed:24590577 + + a(MESH:"Gastrointestinal Tract") association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") + - pmid:18070606 + pubmed:29626319 - p(RGD:Syk) increases p(RGD:Mapt, pmod(Ph, Tyr, 18)) + a(MESH:"Gastrointestinal Tract") decreases a(CHEBI:amyloid-beta) - pmid:26501932 + pubmed:29626319 - a(CHEBI:"1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate") partOf a(GO:"synaptic vesicle") + a(MESH:"Gastrointestinal Tract") decreases a(CHEBI:"amyloid-beta polypeptide 40") - pmid:26501932 + pubmed:29626319 - a(CHEBI:"1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate") partOf a(HBP:"GVD bodies") + a(MESH:"Gastrointestinal Tract") causesNoChange a(CHEBI:"amyloid-beta polypeptide 42") - pmid:26501932 + pubmed:24511233 - a(CHEBI:"1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate") partOf a(HBP:pretangles) + path(MESH:Anhedonia) biomarkerFor path(MESH:Schizophrenia) - pmid:25331948 + pubmed:24511233 - p(HBP:"Tau epitope, CP13") equivalentTo p(HGNC:MAPT, pmod(Ph, Ser, 202)) + path(MESH:"Social Isolation") biomarkerFor path(MESH:Schizophrenia) - pmid:25331948 + pubmed:30988501 - a(PUBCHEM:10200390) directlyDecreases act(p(HGNC:SYK)) + path(MESH:"Social Isolation") increases deg(a(MESH:"Blood-Brain Barrier")) - pmid:28176663 + pubmed:24511233 - a(HBP:"Braak_Stage V") negativeCorrelation act(p(HGNC:GSK3B), ma(kin)) + path(MESH:"Memory, Short-Term") association path(MESH:Schizophrenia) - pmid:28176663 + pubmed:18986241 - a(HBP:"advanced glycation end product") increases p(HGNC:MAPT, pmod(Ph, Thr, 181)) + path(MESH:"Memory, Short-Term") association path(MESH:"Cholinergic Neurons") - pmid:28176663 + pubmed:24511233 - a(HBP:"advanced glycation end product") increases p(HGNC:MAPT, pmod(Ph, Ser, 214)) + path(MESH:Attention) association path(MESH:Schizophrenia) - pmid:28176663 + pubmed:17009926 - a(HBP:"advanced glycation end product") increases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + path(MESH:Attention) association p(FPLX:CHRN) - pmid:25987199 + pubmed:22530628 - act(a(HBP:"advanced glycation end product")) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + path(MESH:Attention) positiveCorrelation a(CHEBI:nicotine) - pmid:26118667 + pubmed:22530628 - p(HBP:"CDK5R1 p25") negativeCorrelation p(HGNC:CDK5R1) + path(MESH:Attention) association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:26118667 + pubmed:26813123 - p(HBP:"CDK5R1 p25") equivalentTo p(HGNC:CDK5R1, frag("99_307")) + path(MESH:Attention) association bp(GO:"synaptic transmission, cholinergic") - pmid:26118667 + pubmed:24590577 - p(HBP:"CDK5R1 p25") positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:Attention) association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") - pmid:26118667 + pubmed:25514383 - p(HBP:"CDK5R1 p25") positiveCorrelation a(GO:"neurofibrillary tangle") + path(MESH:Attention) association a(HP:"cholinergic neuron") - pmid:26118667 + pubmed:18986241 - p(HBP:"CDK5R1 p25") regulates p(HGNC:MAPT, pmod(Ph)) + path(MESH:Attention) association path(MESH:"Cholinergic Neurons") - pmid:27087442 + pubmed:24511233 - p(HBP:"CDK5R1 p25") positiveCorrelation p(HBP:"Tau epitope, AT8") + a(CHEBI:"antipsychotic agent") regulates p(HGNC:DRD2) - pmid:14642273 + pubmed:24511233 - p(HBP:"CDK5R1 p25") directlyIncreases act(p(MGI:Cdk5), ma(kin)) + a(CHEBI:"antipsychotic agent") causesNoChange bp(GO:cognition) - pmid:26118667 + pubmed:23393546 - p(HGNC:CDK5R1, frag("99_307")) equivalentTo p(HBP:"CDK5R1 p25") + p(HGNC:DRD2) association path(DOID:"Huntington's disease") - pmid:26118667 + pubmed:23393546 - path(HBP:"Chronic cerebral hypoperfusion") increases p(RGD:Mapt, pmod(Ph, Ser, 202)) + p(HGNC:DRD2) association path(DOID:"Huntington's disease") - pmid:26118667 + pubmed:24511233 - path(HBP:"Chronic cerebral hypoperfusion") increases p(RGD:Mapt, pmod(Ph, Thr, 205)) + bp(GO:"gamma-aminobutyric acid signaling pathway") association path(MESH:Schizophrenia) - pmid:26118667 + pubmed:24511233 - path(HBP:"Chronic cerebral hypoperfusion") increases p(RGD:Mapt, pmod(Ph, Ser, 262)) + a(CHEBI:xanomeline) increases bp(GO:cognition) - pmid:26118667 + pubmed:26813123 - path(HBP:"Chronic cerebral hypoperfusion") increases p(RGD:Mapt, pmod(Ph, Thr, 231)) + a(CHEBI:xanomeline) increases bp(GO:cognition) - pmid:26118667 + pubmed:24590577 - path(HBP:"Chronic cerebral hypoperfusion") increases p(RGD:Mapt, pmod(Ph, Ser, 422)) + a(CHEBI:xanomeline) increases bp(GO:cognition) - pmid:26118667 + pubmed:24511233 - path(HBP:"Chronic cerebral hypoperfusion") increases p(HBP:"CDK5R1 p25") + a(CHEBI:xanomeline) decreases path(MESH:Hallucinations) - pmid:26118667 + pubmed:26813123 - path(HBP:"Chronic cerebral hypoperfusion") increases p(FPLX:NFkappaB) + a(CHEBI:xanomeline) decreases path(MESH:Hallucinations) - pmid:26118667 + pubmed:24511233 - m(MIRBASE:"rno-mir-195") decreases p(HGNC:MAPT, pmod(Ph, Ser, 202)) + a(CHEBI:xanomeline) decreases path(MESH:Delusions) - pmid:26118667 + pubmed:24511233 - m(MIRBASE:"rno-mir-195") decreases p(HGNC:MAPT, pmod(Ph, Thr, 205)) + a(CHEBI:xanomeline) decreases path(MESH:Schizophrenia) - pmid:26118667 + pubmed:24511233 - m(MIRBASE:"rno-mir-195") decreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + a(CHEBI:xanomeline) increases bp(GO:learning) - pmid:26118667 + pubmed:24511233 - m(MIRBASE:"rno-mir-195") decreases p(HGNC:MAPT, pmod(Ph, Thr, 231)) + a(CHEBI:xanomeline) increases path(MESH:"Memory, Short-Term") - pmid:26118667 + pubmed:24511233 - m(MIRBASE:"rno-mir-195") decreases p(HGNC:MAPT, pmod(Ph, Ser, 422)) + a(CHEBI:xanomeline) association a(MESH:"Gastrointestinal Tract") - pmid:26118667 + pubmed:26813123 - m(MIRBASE:"rno-mir-195") decreases act(p(HBP:"CDK5R1 p25")) + a(CHEBI:xanomeline) increases bp(GO:memory) - pmid:26118667 + pubmed:24590577 - m(MIRBASE:"rno-mir-195") increases complex(g(RGD:Cdk5r1), m(MIRBASE:"rno-mir-195")) + a(CHEBI:xanomeline) increases bp(GO:memory) - pmid:26118667 + pubmed:26813123 - m(MIRBASE:"rno-mir-195") decreases p(RGD:App) + a(CHEBI:xanomeline) decreases path(MESH:"Mood Disorders") - pmid:26118667 + pubmed:26813123 - m(MIRBASE:"rno-mir-195") decreases p(RGD:Bace1) + a(CHEBI:xanomeline) decreases path(MESH:"Psychomotor Agitation") - pmid:26118667 + pubmed:24590577 - m(MIRBASE:"rno-mir-195") decreases a(CHEBI:"amyloid-beta") + a(CHEBI:xanomeline) decreases path(MESH:"Psychotic Disorders") - pmid:26118667 + pubmed:24590577 - m(MIRBASE:"rno-mir-195") decreases p(RGD:Cdk5r1) + a(CHEBI:xanomeline) decreases path(MESH:"Psychotic Disorders") - + + + pubmed:24590577 + + a(CHEBI:xanomeline) increases act(p(HGNC:CHRM1)) + - pmid:26118667 + pubmed:24590577 - complex(g(RGD:Cdk5r1), m(MIRBASE:"rno-mir-195")) decreases r(RGD:Cdk5r1) + a(CHEBI:xanomeline) increases act(p(HGNC:CHRM4)) - + + + pubmed:24511233 + + p(MGI:Chrm1) decreases act(a(CHEBI:amyloid-beta)) + - pmid:26118667 + pubmed:24590577 - complex(g(MIRBASE:"rno-mir-195"), p(FPLX:NFkappaB)) decreases m(MIRBASE:"rno-mir-195") + p(MGI:Chrm1) increases bp(GO:cognition) - + + + pubmed:24590577 + + p(MGI:Chrm1) increases bp(GO:"long-term synaptic potentiation") + - pmid:26118667 + pubmed:24590577 - rxn(reactants(p(RGD:Cdk5r1)), products(p(HBP:"CDK5R1 p25"))) positiveCorrelation act(p(FPLX:CAPN)) + act(p(MGI:Chrm1)) decreases bp(CONSO:"APP processing") - pmid:25987199 + pubmed:24590577 - act(p(MGI:Glp1r)) regulates act(p(MGI:Ppargc1a)) + act(p(MGI:Chrm1)) decreases path(MESH:"Plaque, Amyloid") - pmid:25987199 + pubmed:18986241 - act(p(MGI:Glp1r)) decreases act(p(MGI:Gsk3b), ma(kin)) + act(p(MGI:Chrm1)) increases act(p(MGI:Adam17)) - pmid:25987199 + pubmed:24511233 - act(p(MGI:Glp1r)) decreases p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) + a(MESH:"4-(3-(4-butylpiperidin-1-yl)propyl)-7-fluoro-4H-benzo(1,4)oxazin-3-one") increases act(p(HGNC:CHRM1)) - pmid:25125464 + pubmed:24590577 - a(PUBCHEM:9821250) decreases p(MGI:Mapt, pmod(Ph, Ser, 202)) + a(MESH:"4-(3-(4-butylpiperidin-1-yl)propyl)-7-fluoro-4H-benzo(1,4)oxazin-3-one") increases bp(GO:cognition) - pmid:25125464 + pubmed:24590577 - a(PUBCHEM:9821250) decreases p(MGI:Mapt, pmod(Ph, Thr, 204)) + a(MESH:"4-(3-(4-butylpiperidin-1-yl)propyl)-7-fluoro-4H-benzo(1,4)oxazin-3-one") association a(MESH:"Antipsychotic Agents") - pmid:25125464 + pubmed:24511233 - a(PUBCHEM:9821250) decreases p(MGI:Mapt, pmod(Ph, Ser, 396)) + a(MESH:"1-(3-(4-butyl-1-piperidinyl)propyl)-3,4-dihydro-2(1H)-quinolinone") increases act(p(HGNC:CHRM1)) - pmid:25125464 + pubmed:24590577 - a(PUBCHEM:9821250) decreases p(MGI:Mapt, pmod(Ph, Ser, 404)) + a(MESH:"1-(3-(4-butyl-1-piperidinyl)propyl)-3,4-dihydro-2(1H)-quinolinone") increases act(p(HGNC:CHRM1)) - pmid:25125464 + pubmed:24590577 - a(PUBCHEM:9821250) causesNoChange p(MGI:Mapt, pmod(Ph, Ser, 262)) + a(MESH:"1-(3-(4-butyl-1-piperidinyl)propyl)-3,4-dihydro-2(1H)-quinolinone") increases act(a(MESH:"Pyramidal Cells")) - pmid:25125464 + pubmed:24511233 - a(PUBCHEM:9821250) causesNoChange p(MGI:Mapt, pmod(Ph, Ser, 422)) + a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") increases act(p(HGNC:CHRM1)) - pmid:25125464 + pubmed:24590577 - a(PUBCHEM:9821250) decreases p(FPLX:JNK, pmod(Ph, Ser, 404)) + a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") increases act(p(HGNC:CHRM1)) - pmid:25125464 + pubmed:24511233 - a(GO:"neuron spine") positiveCorrelation p(MGI:Fyn) + a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") decreases act(a(CHEBI:scopolamine)) - pmid:22833681 + pubmed:24511233 - p(HBP:"Tau epitope, AT180") equivalentTo p(HGNC:MAPT, pmod(Ph, Thr, 231)) + a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") decreases a(CHEBI:amyloid-beta) - pmid:22833681 + pubmed:24590577 - p(HGNC:MAPT, pmod(Ph, Thr, 214)) partOf p(HBP:"Tau epitope, AT100") + a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") decreases a(CHEBI:amyloid-beta) - pmid:23294633 + pubmed:24590577 - p(HGNC:MAPT, pmod(Ph, Thr, 214)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) + a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one") increases bp(GO:"NMDA selective glutamate receptor signaling pathway") - pmid:22833681 + pubmed:24511233 - p(HGNC:MAPT, pmod(Ph, Ser, 212)) partOf p(HBP:"Tau epitope, AT100") + act(a(CHEBI:scopolamine)) decreases bp(GO:"behavioral fear response") + + - pmid:23294633 + pubmed:24511233 - p(HGNC:MAPT, pmod(Ph, Ser, 212)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) + a(MESH:VU0357017) increases complex(a(MESH:VU0357017), p(HGNC:CHRM1)) - pmid:22833681 + pubmed:24511233 - path(HBP:"Long-Term Depression") positiveCorrelation act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) + a(MESH:VU0357017) decreases act(a(CHEBI:scopolamine)) - pmid:22833681 + pubmed:24511233 - a(HBP:"Thiamet G") directlyDecreases act(p(ECCODE:"3.2.1.169")) + a(MESH:VU0357017) increases bp(GO:"behavioral fear response") - pmid:22833681 + pubmed:24590577 - act(p(ECCODE:"3.2.1.169")) increases p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) + a(MESH:VU0357017) increases act(p(HGNC:CHRM1)) - pmid:23294633 + pubmed:24590577 - p(MGI:Gsk3b, pmod(Ph, Tyr, 279)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) + a(MESH:VU0357017) causesNoChange act(p(HGNC:CHRM2)) - pmid:23294633 + pubmed:24590577 - p(MGI:Gsk3b, pmod(Ph, Tyr, 279)) increases act(p(MGI:Gsk3b), ma(kin)) + a(MESH:VU0357017) causesNoChange act(p(HGNC:CHRM5)) - pmid:23294633 + pubmed:24590577 - p(MGI:Gsk3b, pmod(Ph, Tyr, 216)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) + a(MESH:VU0357017) decreases path(MESH:"Cognitive Dysfunction") - pmid:23294633 + pubmed:24590577 - p(MGI:Gsk3b, pmod(Ph, Tyr, 216)) increases act(p(MGI:Gsk3b), ma(kin)) + a(MESH:VU0357017) increases bp(GO:learning) - pmid:22002427 + pubmed:24511233 - p(HGNC:MAPT, pmod(Ph, Ser, 205)) positiveCorrelation p(HGNC:MAPT, var("p.Glu391*")) + complex(a(MESH:VU0357017), p(HGNC:CHRM1)) increases act(p(HGNC:CHRM1)) - pmid:24251416 + pubmed:24511233 - p(HGNC:MAPT, pmod(Ph, Ser, 352)) partOf p(HBP:"tubulin-binding repeat 4") + complex(a(MESH:"GSK 1034702"), p(HGNC:CHRM1)) increases bp(GO:cognition) @@ -159281,772 +160519,726 @@

Statements

- pmid:25031639 + pubmed:24511233 - p(HBP:"KXGS motif", pmod(Ph)) increases a(GO:"neurofibrillary tangle") + a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases act(p(HGNC:CHRM1)) - - - - - - - - - - - - - - - - - pmid:22156579 + pubmed:24511233 - act(p(RGD:Dlg4)) negativeCorrelation p(HGNC:MARK4) + a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases bp(GO:"excitatory postsynaptic potential") - pmid:22156579 + pubmed:24511233 - p(RGD:Gria1) negativeCorrelation p(HGNC:MARK4) + a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") decreases act(a(CHEBI:scopolamine)) - - - - - pmid:23722080 + pubmed:24511233 - a(CHEBI:"sodium azide") directlyDecreases a(GO:mitochondrion) + a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases bp(GO:"behavioral fear response") - pmid:23722080 + pubmed:24511233 - a(CHEBI:"sodium azide") positiveCorrelation composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) + a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases bp(GO:learning) - - - pmid:23722080 + pubmed:24590577 - composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) positiveCorrelation a(CHEBI:"hydrogen peroxide") + a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases bp(GO:learning) - - - pmid:23722080 + pubmed:24511233 - composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) positiveCorrelation a(CHEBI:"sodium azide") + a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases bp(GO:memory) - pmid:23722080 + pubmed:24590577 - composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) increases a(CHEBI:"glutamate(1-)") + a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") increases complex(a(CHEBI:acetylcholine), p(HGNC:CHRM1)) - pmid:23722080 + pubmed:24590577 - composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) increases p(RGD:Gsk3b, pmod(Ph)) + a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid") regulates bp(CONSO:"APP processing") - pmid:23722080 + pubmed:24511233 - composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) increases p(RGD:Mapt, pmod(Ph)) + a(MESH:"Prefrontal Cortex") association bp(GO:cognition) - pmid:23722080 + pubmed:24511233 - composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) increases p(RGD:Bace1) + a(MESH:"Prefrontal Cortex") association bp(GO:learning) - pmid:23722080 + pubmed:24511233 - composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) increases p(HBP:"CDK5R1 p25") + a(MESH:"Prefrontal Cortex") association bp(GO:memory) - pmid:23722080 + pubmed:24511233 - composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) decreases bp(GO:"cellular metabolic process") + a(MESH:"VU 0405652") increases act(p(HGNC:CHRM1)) - pmid:29421605 + pubmed:24511233 - p(RGD:Gsk3b, pmod(Ph)) negativeCorrelation bp(GO:aging) + a(CONSO:VU0456940) increases act(p(HGNC:CHRM1)) - - - - - - - pmid:23722080 + pubmed:24511233 - composite(a(CHEBI:"L-ascorbic acid"), a(CHEBI:Trolox), a(CHEBI:glutathione)) decreases p(RGD:Mapt, pmod(HBP:hyperphosphorylation)) + a(MESH:"6-(4-butylthio-1,2,5-thiadiazol-3-yl)-1-azabicyclo(3.2.1)octane") decreases act(a(CHEBI:apomorphine)) - pmid:23722080 + pubmed:24511233 - composite(a(CHEBI:"L-ascorbic acid"), a(CHEBI:Trolox), a(CHEBI:glutathione)) increases bp(GO:"cellular metabolic process") + a(MESH:"6-(4-butylthio-1,2,5-thiadiazol-3-yl)-1-azabicyclo(3.2.1)octane") decreases path(MESH:"Avoidance Learning") - pmid:22952452 + pubmed:24511233 - p(HGNC:TRAK1) increases bp(GO:"axonal transport of mitochondrion") + act(a(CHEBI:apomorphine)) decreases bp(GO:"prepulse inhibition") - pmid:22952452 + pubmed:24511233 - p(HGNC:TRAK1) decreases path(HBP:Neurodegeneration) + act(a(CHEBI:apomorphine)) decreases bp(GO:"prepulse inhibition") - pmid:22952452 + pubmed:24511233 - p(HGNC:TRAK1) decreases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + path(MESH:"Avoidance Learning") association p(HGNC:CHRM4) - pmid:22952452 + pubmed:24511233 - p(HGNC:TRAK1) decreases act(p(HGNC:MARK1)) + a(MESH:"Corpus Striatum") association p(HGNC:CHRM4) - pmid:23001711 + pubmed:24590577 - p(HGNC:CHEK2) increases p(HGNC:MAPT, pmod(Ph, Ser, 262)) + a(MESH:"Corpus Striatum") association p(HGNC:CHRM4) - pmid:22072628 + pubmed:24590577 - p(HBP:"proline-rich region 2", pmod(Ph)) positiveCorrelation bp(MESH:"Protein Conformation, alpha-Helical") + a(MESH:"Corpus Striatum") association p(HGNC:CHRM1) - - - pmid:22072628 + pubmed:24762290 - p(HGNC:MAPT, frag("235_324")) association bp(MESH:"Protein Conformation, alpha-Helical") + a(MESH:"Corpus Striatum") association complex(CONSO:"alpha-4 beta-2 nAChR") - pmid:8226987 + pubmed:30027901 - p(HGNC:MAPT, pmod(Ph, Ser, 261)) decreases complex(a(MESH:Microtubules), p(HGNC:MAPT)) + a(MESH:"Corpus Striatum") increases a(MESH:"GABAergic Neurons") - pmid:24401760 + pubmed:24511233 - p(HGNC:ITPKB) positiveCorrelation path(MESH:"Plaque, Amyloid") + a(MESH:Neocortex) association p(HGNC:CHRM4) - pmid:24401760 + pubmed:24590577 - p(HGNC:ITPKB) positiveCorrelation a(HBP:"dystrophic neurite") + a(MESH:Neocortex) association p(HGNC:CHRM2) - pmid:24401760 + pubmed:24511233 - p(MGI:Itpkb) increases bp(GO:"apoptotic process") + a(CONSO:VU10010) increases act(a(CHEBI:acetylcholine)) - pmid:24401760 + pubmed:24511233 - p(MGI:Itpkb) increases act(p(MGI:Bace1)) + a(CONSO:VU10010) increases act(p(HGNC:CHRM4)) - pmid:24401760 + pubmed:24511233 - p(MGI:Itpkb) increases act(p(MGI:Map2k1)) + a(MESH:"3-amino-N-(4-methoxybenzyl)-4,6-dimethylthieno(2,3-b)pyridine-2-carboxamide") decreases act(a(CHEBI:amphetamine)) - pmid:24401760 + pubmed:24511233 - p(MGI:Itpkb) increases act(p(MGI:Map2k2)) + a(CONSO:VU0152099) decreases act(a(CHEBI:amphetamine)) - pmid:24401760 + pubmed:24511233 - p(MGI:Itpkb) increases path(HBP:Astrogliosis) + a(MESH:"3-amino-5-chloro-6-methoxy-4-methyl-thieno(2,3-b)pyridine-2-carboxylic acid cyclopropylamide") decreases act(a(CHEBI:amphetamine)) - pmid:24401760 + pubmed:11230871 - p(MGI:Itpkb) increases p(HGNC:APP, frag("672_711")) + a(CHEBI:neurotransmitter) association bp(GO:cognition) - pmid:24401760 + pubmed:14556719 - p(MGI:Itpkb) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + tloc(a(CHEBI:neurotransmitter), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) association p(HGNC:SYT11, pmod(go:0016567 ! "protein ubiquitination")) - pmid:24401760 + pubmed:21787755 - a(PUBCHEM:9549284) directlyDecreases p(MGI:Map2k1) + path(MESH:Reward) association complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) - pmid:24401760 + pubmed:21787755 - a(PUBCHEM:9549284) directlyDecreases p(MGI:Map2k2) + path(MESH:Reward) association p(CONSO:"alpha-6-containing nAChR") - pmid:24401760 + pubmed:21787755 - a(PUBCHEM:9549284) decreases a(CHEBI:"amyloid-beta") + path(MESH:Reward) association r(HGNC:CHRNA6) - pmid:23737518 + pubmed:21787755 - a(PUBCHEM:54581340) directlyDecreases act(p(RGD:Cdk5)) + path(MESH:Reward) association p(HGNC:CHRNA6) - pmid:23737518 + pubmed:28901280 - a(PUBCHEM:54581340) decreases p(HBP:"Tau epitope, PHF1") + path(MESH:Reward) association p(MESH:"Receptors, Nicotinic") - pmid:23737518 + pubmed:27190210 - a(PUBCHEM:54581340) decreases act(p(HBP:"CDK5R1 p25")) + path(DOID:schizophrenia) decreases p(HGNC:CHRNA7) - pmid:23737518 + pubmed:22530628 - a(PUBCHEM:54581340) directlyDecreases act(p(RGD:Gsk3b)) + path(DOID:schizophrenia) association p(HGNC:CHRNA7) - pmid:23737518 + pubmed:26979166 - a(PUBCHEM:54581340) isA a(HBP:diaminothiazole) + path(DOID:schizophrenia) decreases act(p(HGNC:CHRNA7)) - pmid:23737518 + pubmed:27190210 - a(HBP:diaminothiazole) decreases p(HGNC:MAPT, pmod(Ph, Ser, 404)) + path(DOID:schizophrenia) association g(HGNC:CHRNA7) - pmid:23737518 + pubmed:27190210 - a(HBP:diaminothiazole) increases bp(GO:memory) + path(DOID:schizophrenia) association g(HGNC:CHRFAM7A) - pmid:23737518 + pubmed:29428175 - a(HBP:"LDN-193665") isA a(HBP:diaminothiazole) + path(DOID:schizophrenia) association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") - pmid:23737518 + pubmed:26979166 - a(HBP:"LDN-193665") directlyDecreases act(p(RGD:Cdk5)) + path(DOID:schizophrenia) increases path(HP:Delusions) - pmid:23737518 + pubmed:26979166 - a(HBP:"LDN-193665") directlyDecreases act(p(RGD:Gsk3b)) + path(DOID:schizophrenia) increases path(HP:Hallucinations) - pmid:23737518 + pubmed:26979166 - a(HBP:"LDN-213843") isA a(HBP:diaminothiazole) + path(DOID:schizophrenia) increases path(HP:Anhedonia) - pmid:23737518 + pubmed:26979166 - a(HBP:"LDN-213843") directlyDecreases act(p(RGD:Cdk5)) + path(DOID:schizophrenia) decreases bp(GO:"learning or memory") - pmid:23737518 + pubmed:26979166 - a(HBP:"LDN-213843") directlyDecreases act(p(RGD:Gsk3b)) + path(DOID:schizophrenia) decreases bp(GO:cognition) - pmid:7667312 + pubmed:26979166 - p(HGNC:MAPT, var("p.Cys291Ala")) decreases a(HBP:"paired helical filaments") + path(DOID:schizophrenia) positiveCorrelation deg(a(MESH:"White Matter")) - pmid:7667312 + pubmed:26979166 - a(HBP:"Thioflavin S") positiveCorrelation a(HBP:"paired helical filaments") + path(DOID:schizophrenia) association path(MESH:Smoking) - pmid:25672970 + pubmed:26979166 - a(HBP:"C-30-27") directlyDecreases act(p(HGNC:KAT2B)) + path(DOID:schizophrenia) positiveCorrelation p(HGNC:CHRNA7, var("?")) - pmid:25672970 + pubmed:26979166 - a(HBP:"C-30-27") decreases p(FPLX:NFkappaB, pmod(Ac, Lys, 122)) + path(DOID:schizophrenia) positiveCorrelation p(HGNC:CHRFAM7A, var("?")) - pmid:25672970 + pubmed:30562574 - a(HBP:"C-30-27") decreases bp(GO:"neuroinflammatory response") + path(DOID:schizophrenia) association p(HGNC:DPYSL2) - pmid:25672970 + pubmed:30988501 - a(HBP:"C-30-27") increases path(MESH:Cognition) + path(DOID:schizophrenia) increases path(MESH:Inflammation) - pmid:25672970 + pubmed:30988501 - a(HBP:"C-30-27") increases bp(GO:locomotion) + path(DOID:schizophrenia) positiveCorrelation p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits") - pmid:25672970 + pubmed:30988501 - a(HBP:"C-30-27") increases bp(GO:"synaptic transmission, cholinergic") + path(DOID:schizophrenia) negativeCorrelation p(HGNC:IL6) - pmid:25672970 + pubmed:30988501 - act(p(HGNC:KAT2B)) increases p(FPLX:NFkappaB, pmod(Ac, Lys, 122)) + path(DOID:schizophrenia) negativeCorrelation p(HGNC:IL2) - pmid:25546293 + pubmed:30988501 - p(HGNC:KAT2B) increases p(HGNC:CTNNB1, pmod(Ac, Lys, 49)) + path(DOID:schizophrenia) negativeCorrelation p(HGNC:IL1B) - pmid:24686445 + pubmed:30988501 - act(p(HGNC:KAT2B)) increases p(HBP:"Histone H3", pmod(Ac, Lys, 9)) + path(DOID:schizophrenia) negativeCorrelation p(HGNC:IL17A) - - - pmid:24844691 + pubmed:30988501 - a(PUBCHEM:49850262) directlyDecreases act(p(HGNC:HDAC6)) + path(DOID:schizophrenia) negativeCorrelation p(HGNC:CRP) - pmid:24844691 + pubmed:30988501 - a(PUBCHEM:49850262) increases bp(GO:behavior) + path(DOID:schizophrenia) positiveCorrelation p(HGNC:C4A) - pmid:24844691 + pubmed:27190210 - a(PUBCHEM:49850262) decreases a(CHEBI:"amyloid-beta") + path(DOID:"autism spectrum disorder") association g(HGNC:CHRNA7) - pmid:24844691 + pubmed:30988501 - a(PUBCHEM:49850262) decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + path(DOID:"autism spectrum disorder") isA path(MESH:"Neurodevelopmental Disorders") - pmid:24844691 + pubmed:30988501 - a(PUBCHEM:49850262) increases p(FPLX:Tubulin, pmod(Ac)) + path(DOID:"autism spectrum disorder") decreases bp(GO:"social behavior") - pmid:24844691 + pubmed:30988501 - a(PUBCHEM:49850262) increases bp(GO:autophagy) + path(DOID:"autism spectrum disorder") positiveCorrelation bp(MESH:"Immunity, Maternally-Acquired") - pmid:25546293 + pubmed:30988501 - p(HGNC:CTNNB1, pmod(Ph, Ser, 33)) increases deg(p(HGNC:CTNNB1)) + path(DOID:"autism spectrum disorder") negativeCorrelation composite(a(CHEBI:minocycline), a(CHEBI:risperidone)) - pmid:25546293 + pubmed:27190210 - p(HGNC:CTNNB1, pmod(Ph, Ser, 33)) increases act(p(HGNC:BTRC)) + path(DOID:"attention deficit hyperactivity disorder") association g(HGNC:CHRNA7) - pmid:25546293 + pubmed:27190210 - p(HGNC:CTNNB1, pmod(Ph, Ser, 37)) increases deg(p(HGNC:CTNNB1)) + path(DOID:epilepsy) association g(HGNC:CHRNA7) - pmid:25546293 + pubmed:27190210 - p(HGNC:CTNNB1, pmod(Ph, Ser, 37)) increases act(p(HGNC:BTRC)) + bp(GO:"sensory processing") negativeCorrelation g(HGNC:CHRNA7) - pmid:25546293 + pubmed:26813123 - p(HGNC:CTNNB1, pmod(Ph, Thr, 41)) increases deg(p(HGNC:CTNNB1)) + bp(GO:"sensory processing") association bp(GO:"synaptic transmission, cholinergic") - pmid:25546293 + pubmed:21482353 - p(HGNC:CTNNB1, pmod(Ph, Thr, 41)) increases act(p(HGNC:BTRC)) + bp(GO:"sensory processing") association bp(GO:"synaptic transmission, cholinergic") - pmid:25546293 + pubmed:27190210 - p(HGNC:CTNNB1, pmod(Ub)) increases act(p(FPLX:Proteasome)) + g(HGNC:CHRFAM7A) association path(DOID:schizophrenia) - pmid:25546293 + pubmed:26979166 - p(HGNC:CTNNB1, pmod(Ac, Lys, 49)) decreases p(HGNC:CTNNB1, pmod(Ub)) + g(HGNC:CHRFAM7A) decreases act(p(HGNC:CHRNA7)) - - - pmid:25546293 - - p(HGNC:CTNNB1, pmod(Ac, Lys, 49)) increases p(HGNC:CTNNB1, loc(GO:membrane)) - - - pmid:27917100 + pubmed:27190210 - a(HBP:ST7612AA1) directlyDecreases act(p(FPLX:HDAC)) + p(HGNC:CHRFAM7A) decreases p(HGNC:CHRNA7) - pmid:26890116 + pubmed:28901280 - a(HBP:"Biphenyl-4-yl-acrylohydroxamoc acids") directlyDecreases act(p(FPLX:HDAC)) + p(HGNC:CHRFAM7A, loc(MESH:Oocytes)) decreases act(p(HGNC:CHRNA7, loc(MESH:Oocytes))) - - - pmid:18558669 - - a(HBP:Trithiocarbonates) directlyDecreases act(p(HGNC:HDAC6)) - - - pmid:29540553 + pubmed:27190210 - p(MGI:Sirt1) decreases p(MGI:Mapt, pmod(Ac, Lys, 174)) + complex(a(CONSO:"amyloid-beta 42 oligomers"), complex(CONSO:"alpha-7 beta-2 nAChR")) decreases act(complex(CONSO:"alpha-7 beta-2 nAChR")) + + - pmid:29540553 + pubmed:25514383 - p(MGI:Sirt1) decreases a(MESH:Synapses) + a(CONSO:"amyloid-beta 42 oligomers") increases bp(GO:"long-term synaptic potentiation") - pmid:29540553 + pubmed:22419736 - p(MGI:Sirt1) increases bp(GO:behavior) + a(CONSO:"amyloid-beta 42 oligomers") association path(MESH:Tauopathies) - pmid:29540553 + pubmed:22419736 - p(MGI:Sirt1) negativeCorrelation path(MESH:Tauopathies) + a(CONSO:"amyloid-beta 42 oligomers") increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) @@ -160055,128 +161247,123 @@

Statements

- pmid:29540553 + pubmed:27190210 - p(MGI:Sirt3) decreases p(HGNC:MAPT) + complex(CONSO:"alpha-7 beta-2 nAChR") association path(DOID:"Alzheimer's disease") - pmid:29540553 + pubmed:26979166 - p(MGI:Sirt3) decreases p(HGNC:MAPT, pmod(Ac)) + complex(CONSO:"alpha-7 beta-2 nAChR") decreases deg(a(MESH:"Cholinergic Neurons")) - pmid:29540553 + pubmed:27190210 - p(MGI:Sirt3) negativeCorrelation path(MESH:"Alzheimer Disease") + bp(GO:"cell migration") association p(HGNC:CHRNA7) - pmid:27550730 + pubmed:27190210 - a(PUBCHEM:136299192) directlyDecreases act(p(MGI:Pde5a)) + bp(GO:"regulation of phosphatidylinositol 3-kinase signaling") decreases tloc(a(MESH:Cytokines), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:27550730 + pubmed:27190210 - a(PUBCHEM:136299192) directlyDecreases act(p(FPLX:HDAC)) + bp(GO:"regulation of phosphatidylinositol 3-kinase signaling") decreases path(MESH:Inflammation) - pmid:27550730 + pubmed:27190210 - a(PUBCHEM:136299192) increases bp(GO:"long-term synaptic potentiation") + bp(GO:"regulation of phosphatidylinositol 3-kinase signaling") increases p(HGNC:HMOX1) - pmid:27550730 + pubmed:27190210 - a(PUBCHEM:136299192) decreases a(CHEBI:"amyloid-beta") + bp(GO:"oxygen homeostasis") association bp(GO:"synaptic transmission, cholinergic") - pmid:27550730 + pubmed:27190210 - a(PUBCHEM:136299192) decreases p(MGI:Mapt, pmod(Ph)) + bp(GO:"glucose homeostasis") association bp(GO:"synaptic transmission, cholinergic") - pmid:27550730 + pubmed:27190210 - a(PUBCHEM:136299192) decreases act(p(MGI:Gsk3b), ma(kin)) + complex(a(PUBCHEM:305), p(HGNC:CHRNA7)) increases act(p(HGNC:CHRNA7)) + + - pmid:27550730 + pubmed:26979166 - act(p(HGNC:PDE5A)) negativeCorrelation act(p(FPLX:CREB)) + a(PUBCHEM:305) increases act(p(HGNC:CHRNA7)) - - - pmid:29559585 - - p(MGI:Gapdh, pmod(NO)) increases p(MGI:Ep300, pmod(Ac)) - - - pmid:29559585 + pubmed:27190210 - p(MGI:Gapdh, pmod(NO)) increases act(p(MGI:Ep300)) + composite(p(CONSO:alpha-Bungarotoxin), p(HGNC:CHRNA7)) increases complex(p(CONSO:alpha-Bungarotoxin), p(HGNC:CHRNA7)) - pmid:29559585 + pubmed:26472524 - p(MGI:Gapdh, pmod(NO)) increases p(MGI:Sirt1, pmod(NO)) + composite(p(CONSO:alpha-Bungarotoxin), p(HGNC:CHRNA7)) increases complex(p(CONSO:alpha-Bungarotoxin), p(HGNC:CHRNA7)) - pmid:29559585 + pubmed:27190210 - p(MGI:Gapdh, pmod(NO)) decreases act(p(MGI:Sirt1)) + composite(a(PUBCHEM:187), p(HGNC:CHRNA7)) decreases complex(a(PUBCHEM:187), p(HGNC:CHRNA7)) @@ -160187,845 +161374,829 @@

Statements

- pmid:29559585 + pubmed:27190210 - p(HGNC:GAPDH, pmod(NO)) positiveCorrelation path(MESH:"Alzheimer Disease") + composite(a(CHEBI:nicotine), p(HGNC:CHRNA7)) decreases complex(a(CHEBI:nicotine), p(HGNC:CHRNA7)) - - - pmid:29559585 + pubmed:26979166 - a(PUBCHEM:6419718) decreases p(MGI:Gapdh, pmod(NO)) + composite(a(CHEBI:nicotine), p(HGNC:CHRNA7)) decreases path(MESH:Inflammation) - pmid:29559585 + pubmed:27190210 - a(PUBCHEM:6419718) decreases p(MGI:Mapt, pmod(Ac, Lys, 280)) + a(PUBCHEM:11243536) increases p(HGNC:CHRNA7) - pmid:29559585 + pubmed:27190210 - a(PUBCHEM:6419718) increases bp(GO:memory) + a(PUBCHEM:5310971) increases p(HGNC:CHRNA7) - pmid:29559585 + pubmed:27190210 - a(PUBCHEM:6419718) increases bp(GO:locomotion) + a(PUBCHEM:9797360) increases p(HGNC:CHRNA7) - pmid:28855586 + pubmed:27190210 - p(HGNC:MAPT, pmod(Ac, Lys, 163), pmod(Ac, Lys, 280), pmod(Ac, Lys, 281), pmod(Ac, Lys, 369)) decreases p(HGNC:MAPT, pmod(Ph)) + a(PUBCHEM:5310985) increases p(HGNC:CHRNA7) - pmid:28855586 + pubmed:26979166 - p(HGNC:MAPT, pmod(Ac, Lys, 163), pmod(Ac, Lys, 280), pmod(Ac, Lys, 281), pmod(Ac, Lys, 369)) decreases complex(a(MESH:Microtubules), p(HGNC:MAPT, pmod(Ph))) + a(PUBCHEM:5310985) increases act(p(HGNC:CHRNA7)) - pmid:28855586 + pubmed:26979166 - p(HGNC:MAPT, pmod(Ac, Lys, 163), pmod(Ac, Lys, 280), pmod(Ac, Lys, 281), pmod(Ac, Lys, 369)) negativeCorrelation act(a(CHEBI:"amyloid-beta")) + a(PUBCHEM:5310985) decreases path(DOID:aphasia) - - - - - pmid:19401603 + pubmed:26979166 - complex(a(MESH:Microtubules), p(HGNC:MAPT, pmod(Ph))) positiveCorrelation p(HGNC:MAPT, pmod(Ph)) + a(PUBCHEM:5310985) increases path(HP:Anhedonia) - pmid:28287136 + pubmed:27190210 - p(HGNC:MAPT, pmod(Ac, Lys, 280), pmod(Ac, Lys, 281)) decreases p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205)) + composite(p(HGNC:CHRNA7), p(HGNC:RIC3)) increases act(p(HGNC:CHRNA7, loc(GO:"cell surface"))) - - - pmid:28287136 - - p(HGNC:MAPT, pmod(Ac, Lys, 280), pmod(Ac, Lys, 281)) decreases complex(a(MESH:Microtubules), p(HGNC:MAPT, pmod(Ph))) - + - pmid:28287136 + pubmed:26979166 - p(HGNC:MAPT, pmod(Ac, Lys, 280), pmod(Ac, Lys, 281)) increases a(HBP:"Tau aggregates") + p(HGNC:RIC3) increases act(complex(p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7))) - pmid:28287136 + pubmed:28445721 - p(HGNC:MAPT, var("p.Lys280Gln")) increases a(HBP:"Tau aggregates") + p(HGNC:RIC3) increases act(p(FPLX:CHRN)) - pmid:28002468 + pubmed:28445721 - p(HGNC:MAP4, frag("992_999")) equivalentTo p(HBP:"VQIINK motif") + p(HGNC:RIC3) increases act(p(FPLX:CHRN)) - - - - - pmid:28002468 + pubmed:28445721 - p(HGNC:MAP4, frag("1023_1030")) equivalentTo p(HBP:"VQIINK motif") + p(HGNC:RIC3) increases act(p(FPLX:CHRN)) - pmid:28002468 + pubmed:22040696 - p(HGNC:MAP2, frag("332_339")) equivalentTo p(HBP:"VQIVYK motif") + act(p(HGNC:RIC3), ma(go:0044183 ! "protein binding involved in protein folding")) increases p(FPLX:CHRN) - pmid:28002468 + pubmed:22040696 - bp(HBP:"cystein-dependent auto-acetylation") increases p(HGNC:MAP2, pmod(Ac)) + p(HGNC:RIC3) increases act(p(FPLX:CHRN)) - pmid:27041503 + pubmed:22040696 - p(HGNC:WWC1) association bp(GO:memory) + act(p(HGNC:RIC3), ma(go:0044183 ! "protein binding involved in protein folding")) increases p(FPLX:CHRN) - pmid:27041503 + pubmed:28445721 - p(HGNC:WWC1) negativeCorrelation p(HGNC:MAPT, pmod(Ac)) + p(HGNC:RIC3) causesNoChange complex(a(CHEBI:epibatidine), a(MESH:"nicotinic receptor alpha3beta2")) - pmid:27041503 + pubmed:28445721 - p(MGI:Mapt, pmod(Ac, Lys, 274)) decreases bp(MESH:"Long-Term Potentiation") + p(HGNC:RIC3) causesNoChange complex(a(CHEBI:epibatidine), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + + - pmid:27041503 + pubmed:28445721 - p(MGI:Mapt, pmod(Ac, Lys, 274)) decreases p(MGI:Wwc1) + p(HGNC:RIC3) increases tloc(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) + + - pmid:27041503 + pubmed:22040696 - p(MGI:Mapt, pmod(Ac, Lys, 274)) decreases bp(GO:"actin cytoskeleton reorganization") + p(HGNC:RIC3) regulates bp(GO:"modulation of chemical synaptic transmission") - pmid:27041503 + pubmed:22040696 - p(MGI:Mapt, pmod(Ac, Lys, 281)) decreases bp(MESH:"Long-Term Potentiation") + p(HGNC:RIC3) increases bp(GO:"synaptic transmission, cholinergic") - - - pmid:27041503 - - p(MGI:Mapt, pmod(Ac, Lys, 281)) decreases p(MGI:Wwc1) - + - - - pmid:27041503 - - p(MGI:Mapt, pmod(Ac, Lys, 281)) decreases bp(GO:"actin cytoskeleton reorganization") - + + + - pmid:27041503 + pubmed:22040696 - p(MGI:Wwc1) increases bp(MESH:"Long-Term Potentiation") + p(HGNC:RIC3) decreases act(complex(p(HGNC:CHRNA3), p(HGNC:CHRNB4))) - pmid:26390242 + pubmed:22040696 - a(CHEBI:salsalate) directlyDecreases act(p(HGNC:EP300)) + p(HGNC:RIC3) decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) - pmid:26390242 + pubmed:22040696 - a(CHEBI:salsalate) decreases p(HGNC:MAPT, pmod(Ac, Lys, 174)) + p(HGNC:RIC3) increases p(HGNC:CHRNA9) + + - pmid:26390242 + pubmed:22040696 - a(CHEBI:salsalate) decreases p(HGNC:MAPT) + p(HGNC:RIC3) increases p(HGNC:CHRNA7) + + - pmid:26390242 + pubmed:22040696 - a(CHEBI:salsalate) increases bp(GO:memory) + act(p(HGNC:RIC3), ma(go:0044183 ! "protein binding involved in protein folding")) negativeCorrelation path(MESH:"Bipolar Disorder") - pmid:26390242 + pubmed:22040696 - a(CHEBI:salsalate) decreases path(HBP:Neurodegeneration) + act(p(HGNC:RIC3), ma(go:0044183 ! "protein binding involved in protein folding")) negativeCorrelation path(MESH:"Psychotic Disorders") - pmid:26390242 + pubmed:26472524 - a(CHEBI:salicylate) directlyDecreases act(p(HGNC:EP300)) + tloc(a(MESH:"Cations, Divalent"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) increases bp(GO:"membrane depolarization") - pmid:26390242 + pubmed:26472524 - a(CHEBI:salicylate) decreases p(HGNC:MAPT, pmod(Ac, Lys, 174)) + a(MESH:"Cations, Divalent") decreases act(p(MESH:"Receptors, N-Methyl-D-Aspartate"), ma(GO:"NMDA glutamate receptor activity")) - pmid:26390242 + pubmed:17009926 - a(CHEBI:salicylate) decreases p(HGNC:MAPT) + p(HGNC:CHRNA7, var("p.Leu254Thr")) decreases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) - pmid:26390242 + pubmed:17009926 - a(CHEBI:salicylate) increases bp(GO:memory) + p(HGNC:CHRNA7, var("p.Leu254Thr")) decreases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) - pmid:26390242 + pubmed:17009926 - a(CHEBI:salicylate) decreases path(HBP:Neurodegeneration) + p(HGNC:CHRNA7, var("p.Leu255Thr")) decreases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) - pmid:26192747 + pubmed:17009926 - p(HGNC:MAPT, pmod(Ac, Lys, 225)) isA p(HGNC:MAPT, pmod(Ac)) + p(HGNC:CHRNA7, var("p.Leu255Thr")) decreases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) - - - pmid:26192747 - - p(HGNC:MAPT, pmod(Ac, Lys, 317)) isA p(HGNC:MAPT, pmod(Ac)) - + + + - pmid:26192747 + pubmed:17009926 - p(HGNC:MAPT, pmod(Ac, Lys, 317)) partOf p(HBP:"microtubule-binding region") + composite(a(CHEBI:acetylcholine), a(CHEBI:ivermectin)) increases act(p(FPLX:CHRN)) + + - pmid:26192747 + pubmed:17009926 - p(HGNC:MAPT, pmod(Ac, Lys, 331)) isA p(HGNC:MAPT, pmod(Ac)) + a(CHEBI:ivermectin) regulates act(p(HGNC:CHRNA7)) + + - pmid:26192747 + pubmed:17009926 - p(HGNC:MAPT, pmod(Ac, Lys, 331)) partOf p(HBP:"microtubule-binding region") + composite(a(CHEBI:"1,1-dimethyl-4-phenylpiperazinium iodide"), a(CHEBI:ivermectin)) increases act(p(HGNC:CHRNA7)) + + + + - pmid:26192747 + pubmed:17009926 - p(HGNC:MAPT, pmod(Ac, Lys, 343)) isA p(HGNC:MAPT, pmod(Ac)) + composite(a(CHEBI:5-hydroxyindole), a(CHEBI:acetylcholine)) increases act(p(HGNC:CHRNA7)) + + - pmid:26192747 + pubmed:17009926 - p(HGNC:MAPT, pmod(Ac, Lys, 343)) partOf p(HBP:"microtubule-binding region") + a(CHEBI:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methyl-3-isoxazolyl)urea") regulates act(p(HGNC:CHRNA7)) - pmid:26192747 + pubmed:28132910 - p(HGNC:MAPT, pmod(Ac, Lys, 347)) isA p(HGNC:MAPT, pmod(Ac)) + a(CHEBI:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methyl-3-isoxazolyl)urea") increases complex(a(GO:membrane), a(PUBCHEM:16068384)) - pmid:26192747 + pubmed:28132910 - p(HGNC:MAPT, pmod(Ac, Lys, 347)) partOf p(HBP:"microtubule-binding region") + a(CHEBI:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methyl-3-isoxazolyl)urea") increases complex(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"), a(PUBCHEM:16068384)) - pmid:26192747 + pubmed:17009926 - p(HGNC:MAPT, pmod(Ac, Lys, 385)) isA p(HGNC:MAPT, pmod(Ac)) + a(CHEBI:"nicotinic acetylcholine receptor agonist") increases tloc(a(CHEBI:acetylcholine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:24686445 + pubmed:17009926 - path(HBP:"peripheral nervous system injury") increases act(p(FPLX:ERK)) + a(CHEBI:"nicotinic acetylcholine receptor agonist") increases tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - - - pmid:21427723 + pubmed:17009926 - a(CHEBI:"trichostatin A") directlyDecreases act(p(FPLX:HDAC)) + a(CHEBI:"nicotinic acetylcholine receptor agonist") increases tloc(a(CHEBI:noradrenaline), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:21427723 + pubmed:17009926 - a(CHEBI:"trichostatin A") increases p(HGNC:MAPT, pmod(Ac)) + a(CHEBI:"nicotinic acetylcholine receptor agonist") increases tloc(a(CHEBI:serotonin), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:21427723 + pubmed:17009926 - path(HBP:"4R tauopathy") association p(HBP:"4R tau") + a(CHEBI:"nicotinic acetylcholine receptor agonist") increases tloc(a(CHEBI:"glutamate(2-)"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:20869593 + pubmed:17009926 - a(CHEBI:C646) directlyDecreases act(p(HGNC:EP300)) + a(CHEBI:"nicotinic acetylcholine receptor agonist") increases tloc(a(CHEBI:"gamma-aminobutyric acid"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:20869593 + pubmed:17009926 - a(CHEBI:C646) decreases p(HGNC:MAPT, pmod(Ac)) + a(CHEBI:"nicotinic acetylcholine receptor agonist") increases bp(GO:memory) - pmid:29226865 + pubmed:17009926 - p(HGNC:SRSF2, pmod(Ac, Lys, 52)) positiveCorrelation act(p(HGNC:SRSF2)) + a(CHEBI:"nicotinic acetylcholine receptor agonist") increases bp(GO:memory) - pmid:28771976 + pubmed:17009926 - a(PUBCHEM:56650312) directlyDecreases act(p(HGNC:HDAC3)) + a(CHEBI:"nicotinic acetylcholine receptor agonist") increases bp(GO:learning) - pmid:28771976 + pubmed:17009926 - a(HBP:RGFP966) association bp(GO:memory) + a(CHEBI:"nicotinic acetylcholine receptor agonist") increases path(MESH:Attention) - pmid:29844403 + pubmed:17009926 - a(PUBCHEM:132157820) directlyDecreases act(p(HGNC:HDAC6)) + a(CHEBI:"nicotinic acetylcholine receptor agonist") increases bp(GO:cognition) - pmid:29844403 + pubmed:19323834 - a(PUBCHEM:132157820) decreases p(HGNC:MAPT, pmod(Ph)) + a(CHEBI:noradrenaline) increases p(HGNC:SUMO1) - pmid:29844403 + pubmed:30027901 - a(PUBCHEM:132157820) decreases a(HBP:"Tau aggregates") + a(CHEBI:serotonin) association a(MESH:"Hydroxyindoleacetic Acid") + + - pmid:29844403 + pubmed:17009926 - a(PUBCHEM:132157820) increases p(INTERPRO:"Heat shock protein Hsp90 family", pmod(Ac)) + a(CHEBI:tetrodotoxin) decreases act(complex(GO:"voltage-gated calcium channel complex")) - pmid:29844403 + pubmed:17009926 - a(PUBCHEM:132157820) increases p(HGNC:GSK3B, pmod(Ph, Ser, 9)) + bp(GO:"regulation of action potential firing rate") association p(FPLX:CHRN) - pmid:29844403 + pubmed:17009926 - a(PUBCHEM:132157820) decreases p(HGNC:MAPT, pmod(Ph, Ser, 396)) + act(complex(GO:"GABA-A receptor complex")) increases bp(GO:"membrane depolarization") - pmid:29844403 + pubmed:17009926 - a(PUBCHEM:132157820) increases tloc(a(PUBCHEM:132157820), fromLoc(MESH:Blood), toLoc(MESH:Brain)) + bp(GO:"regulation of action potential firing pattern") association p(FPLX:CHRN) - pmid:29844403 + pubmed:17009926 - a(PUBCHEM:132157820) increases bp(GO:learning) + bp(GO:"action potential") increases tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:29844403 + pubmed:17009926 - a(PUBCHEM:132157820) increases bp(GO:memory) + bp(GO:"response to pain") association p(FPLX:CHRN) - pmid:29844403 + pubmed:17009926 - p(INTERPRO:"Heat shock protein Hsp90 family", pmod(Ac)) decreases complex(p(HGNC:HDAC6), p(INTERPRO:"Heat shock protein Hsp90 family")) + a(PUBCHEM:5311278) decreases act(p(HGNC:CHRNA7)) - pmid:29844403 + pubmed:17009926 - p(INTERPRO:"Heat shock protein Hsp90 family", pmod(Ac)) increases p(HGNC:MAPT, pmod(Ph), pmod(Ub)) + a(PUBCHEM:5311278) decreases bp(GO:memory) - - - - - pmid:19732809 + pubmed:25514383 - g(HGNC:OGA, var("?")) decreases act(complex(GO:"proteasome complex")) + a(PUBCHEM:5311278) decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) - pmid:19732809 + pubmed:26813123 - g(HGNC:OGA, var("?")) positiveCorrelation path(MESH:"Alzheimer Disease") + p(FPLX:CHRM) isA a(MESH:"Receptors, G-Protein-Coupled") - - - pmid:26041011 + pubmed:26813123 - a(HBP:"USP14 Aptamer") decreases act(p(HGNC:USP14)) + p(FPLX:CHRM) regulates a(MESH:"Ion Channels") - pmid:27325702 + pubmed:26813123 - p(HBP:"APP, ACR") association p(HGNC:STUB1) + p(FPLX:CHRM) regulates act(a(MESH:"Calcium Channels")) - pmid:27325702 + pubmed:26813123 - p(HBP:"APP, ACR") association p(HBP:"CRL4 complex") + p(FPLX:CHRM) regulates act(a(MESH:"Potassium Channels")) - pmid:27325702 + pubmed:26813123 - p(HBP:"APP, ACR") increases p(HGNC:SCAMP1, pmod(Ub)) + act(p(FPLX:CHRM)) decreases act(a(MESH:"Potassium Channels")) - pmid:27325702 + pubmed:26813123 - p(HBP:"APP, ACR") increases p(HGNC:SV2A, pmod(Ub)) + p(FPLX:CHRM) regulates act(a(MESH:"Chloride Channels")) - pmid:27325702 + pubmed:26813123 - p(HBP:"APP, ACR") increases p(HGNC:SV2B, pmod(Ub)) + act(p(FPLX:CHRM)) decreases bp(GO:"synaptic transmission, glutamatergic") + + + + - pmid:27325702 + pubmed:25514383 - p(HBP:"APP, ACR") increases p(HGNC:VAMP2, pmod(Ub)) + p(FPLX:CHRM) regulates bp(GO:cognition) + + - pmid:27325702 + pubmed:17009926 - p(HBP:"APP, ACR") increases p(HGNC:ATP6V0A1, pmod(Ub)) + p(HGNC:CHRNA4, var("p.Ser248Thr")) increases path(MESH:Epilepsy) - pmid:27325702 + pubmed:17009926 - p(HBP:"APP, ACR") increases p(HGNC:SLC17A7, pmod(Ub)) + g(HGNC:CHRNA4, var("?")) positiveCorrelation path(MESH:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") - pmid:27325702 + pubmed:17009926 - p(HBP:"APP, ACR") increases p(HGNC:SYT1, pmod(Ub)) + path(MESH:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") positiveCorrelation g(HGNC:CHRNA4, var("?")) - pmid:27325702 + pubmed:17009926 - p(HBP:"APP, ACR") increases p(HGNC:SYT2, pmod(Ub)) + path(MESH:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") positiveCorrelation g(HGNC:CHRNB2, var("?")) - pmid:27325702 + pubmed:17009926 - p(HBP:"APP, ACR") increases p(HGNC:RAB14, pmod(Ub)) + g(HGNC:CHRNB2, var("?")) positiveCorrelation path(MESH:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") - pmid:27325702 + pubmed:28445721 - p(HBP:"APP, ACR") increases p(HGNC:SNAP25, pmod(Ub)) + path(MESH:Arousal) association p(FPLX:CHRN) - pmid:27325702 + pubmed:28901280 - p(HBP:"APP, ACR") increases p(HGNC:SYN2, pmod(Ub)) + path(MESH:Arousal) association p(MESH:"Receptors, Nicotinic") - pmid:27325702 + pubmed:26472524 - p(HBP:"APP, ACR") increases p(HGNC:SYN1, pmod(Ub)) + composite(a(CHEBI:nicotine), p(HGNC:CHRNB2)) increases complex(a(CHEBI:nicotine), p(HGNC:CHRNB2)) - pmid:27325702 + pubmed:23702978 - p(HBP:"APP, ACR") increases p(HGNC:RAB3A, pmod(Ub)) + a(CHEBI:"potassium(1+)") decreases bp(GO:"apoptosome assembly") - pmid:27325702 + pubmed:23702978 - p(HBP:"APP, ACR") increases p(HGNC:APOE, pmod(Ub)) + a(CHEBI:"potassium(1+)") increases act(complex(GO:"NLRP1 inflammasome complex")) - pmid:27325702 + pubmed:23702978 - p(HBP:"APP, ACR") increases p(HGNC:MAPT, pmod(Ub)) + a(CHEBI:"potassium(1+)") increases act(complex(GO:"NLRP3 inflammasome complex")) - pmid:27325702 + pubmed:23702978 - p(HBP:"APP, ACR") regulates complex(GO:"ubiquitin ligase complex") + a(CHEBI:"potassium(1+)") increases act(p(HGNC:PYCARD)) - pmid:27325702 + pubmed:23702978 - p(HBP:"CRL4 complex") association p(HBP:"APP, ACR") + a(CHEBI:"potassium(1+)") decreases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) - pmid:27325702 + pubmed:24561250 - p(HBP:"CRL4 complex") equivalentTo complex(p(HGNC:CRBN), p(HGNC:CUL4A), p(HGNC:CUL4B), p(HGNC:DDB1)) + a(CHEBI:"potassium(1+)") increases act(complex(GO:"inflammasome complex")) - pmid:27325702 + pubmed:26472524 - p(HBP:"CRL4 complex") isA complex(GO:"ubiquitin ligase complex") + act(p(MESH:"Receptors, N-Methyl-D-Aspartate")) increases bp(GO:"long-term synaptic potentiation") - - - - - - - - - pmid:27325702 + pubmed:26751493 - complex(p(HGNC:CRBN), p(HGNC:CUL4A), p(HGNC:CUL4B), p(HGNC:DDB1)) equivalentTo p(HBP:"CRL4 complex") + p(MESH:"Receptors, N-Methyl-D-Aspartate") association p(CONSO:"projection domain") @@ -161044,198 +162215,207 @@

Statements

- pmid:25378699 + pubmed:16820021 - p(HGNC:MAPT, pmod(Sumo, Lys, 340)) positiveCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + a(CONSO:"SK and F 77434") decreases a(MESH:"8-iodo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7-ol") + + + + + + + pubmed:16820021 + + a(MESH:antalarmin) causesNoChange act(p(RGD:Drd1)) - pmid:25378699 + pubmed:16820021 - p(HGNC:MAPT, pmod(Sumo, Lys, 340)) increases p(HGNC:MAPT, pmod(Ph)) + a(MESH:antalarmin) increases p(RGD:Drd2) - pmid:25378699 + pubmed:16820021 - p(HGNC:MAPT, pmod(Sumo, Lys, 340)) decreases p(HGNC:MAPT, pmod(Ub)) + a(MESH:antalarmin) decreases p(RGD:Drd2) - pmid:24905733 + pubmed:16820021 - p(HGNC:MARCH7) increases p(HGNC:MAPT, pmod(Ub)) + a(MESH:antalarmin) increases p(RGD:Drd3) - pmid:8391280 + pubmed:16820021 - p(HGNC:MAPT, pmod(Ub, Lys, 254)) positiveCorrelation a(HBP:"paired helical filaments") + a(MESH:antalarmin) decreases p(RGD:Drd3) - pmid:8391280 + pubmed:16820021 - p(HGNC:MAPT, pmod(Ub, Lys, 257)) positiveCorrelation a(HBP:"paired helical filaments") + a(MESH:antalarmin) decreases path(CONSO:"isolation rearing") - pmid:8391280 + pubmed:16820021 - p(HGNC:MAPT, pmod(Ub, Lys, 311)) positiveCorrelation a(HBP:"paired helical filaments") + a(MESH:antalarmin) causesNoChange path(CONSO:"isolation rearing") - pmid:27260838 + pubmed:16820021 - p(HBP:"Tau antibody, TNT1") association p(HBP:"phosphatase-activating domain") + a(MESH:antalarmin) causesNoChange path(CONSO:"isolation rearing") - pmid:27260838 + pubmed:16820021 - p(HBP:"Tau antibody, TNT2") association p(HBP:"phosphatase-activating domain") + a(MESH:antalarmin) causesNoChange r(RGD:Bdnf) - pmid:27601475 + pubmed:16820021 - a(HBP:"8-nitro-cGMP") decreases a(HBP:"Tau oligomers") + a(MESH:antalarmin) causesNoChange p(RGD:Ntrk2) - pmid:27601475 + pubmed:16820021 - a(HBP:"8-nitro-cGMP") positiveCorrelation a(CHEBI:"nitric oxide") + a(MESH:antalarmin) decreases r(RGD:Ntrk2) - pmid:27601475 + pubmed:16820021 - act(p(ECCODE:"1.14.13.39")) directlyIncreases a(CHEBI:"nitric oxide") + a(MESH:antalarmin) increases r(RGD:Ntrk2) - pmid:27373205 + pubmed:29807032 - p(HBP:"Tau dimers") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422)) + a(MESH:antalarmin) decreases bp(MESH:"Heat-Shock Response") - pmid:11606569 + pubmed:29807032 - g(DBSNP:rs63750688) equivalentTo p(HGNC:MAPT, var("p.Lys280del")) + a(MESH:antalarmin) increases act(p(NCBIGENE:140621)) - pmid:19765634 + pubmed:29807032 - g(DBSNP:rs761059) positiveCorrelation path(MESH:"Alzheimer Disease") + a(MESH:antalarmin) causesNoChange a(MESH:"Embryonic Structures") - pmid:19765634 + pubmed:29807032 - g(DBSNP:rs8052688) positiveCorrelation path(MESH:"Cognitive Dysfunction") + a(MESH:antalarmin) causesNoChange a(MESH:"Embryonic Structures") - pmid:19765634 + pubmed:23211705 - g(DBSNP:rs8063) positiveCorrelation path(MESH:"Cognitive Dysfunction") + a(MESH:antalarmin) increases a(MESH:"Embryonic Structures") - pmid:21843595 + pubmed:23211705 - p(MGI:Sumo3) negativeCorrelation bp(GO:learning) + a(MESH:antalarmin) increases a(MESH:Morula) - pmid:21843595 + pubmed:23211705 - p(MGI:Sumo3) negativeCorrelation bp(GO:memory) + a(MESH:antalarmin) increases a(MESH:Blastocyst) - pmid:19782030 + pubmed:23211705 - act(p(RGD:Stat1)) increases r(RGD:Irf1) + a(MESH:antalarmin) decreases act(p(MGI:Crhr1)) - pmid:19782030 + pubmed:23211705 - act(p(RGD:Stat1)) increases r(RGD:Tnf) + a(MESH:antalarmin) decreases act(p(MGI:Crhr1)) - pmid:19782030 + pubmed:23211705 - act(p(RGD:Stat1)) increases r(RGD:Il6) + a(MESH:antalarmin) decreases act(p(MGI:Crh)) @@ -161252,608 +162432,658 @@

Statements

- pmid:19782030 + pubmed:16820021 - p(RGD:Pias1) increases p(RGD:Nr1h2, pmod(Sumo)) + composite(complex(a(CONSO:"[125I]-NCQ 298"), p(RGD:Drd1)), p(MESH:Raclopride)) increases complex(p(MESH:Raclopride), p(RGD:Drd1)) - - - + + + pubmed:16820021 + + path(CONSO:"isolation rearing") increases p(RGD:Drd2) + - pmid:19782030 + pubmed:16820021 - p(RGD:Hdac4) increases p(RGD:Nr1h3, pmod(Sumo)) + path(CONSO:"isolation rearing") increases p(RGD:Drd2) + + + pubmed:16820021 + + path(CONSO:"isolation rearing") increases p(RGD:Drd3) + + - pmid:19782030 + pubmed:16820021 - p(RGD:Nr1h2, pmod(Sumo)) increases act(p(RGD:Stat1)) + path(CONSO:"isolation rearing") increases p(RGD:Drd3) - pmid:19782030 + pubmed:16820021 - p(RGD:Nr1h3, pmod(Sumo)) increases act(p(RGD:Stat1)) + path(CONSO:"isolation rearing") decreases r(RGD:Bdnf) - + + + pubmed:16820021 + + path(CONSO:"isolation rearing") increases r(RGD:Bdnf) + - pmid:19323834 + pubmed:16820021 - complex(p(FPLX:CEBP), p(HGNC:SUMO1)) directlyDecreases r(HGNC:NOS2) + path(CONSO:"isolation rearing") regulates p(RGD:Bdnf) - pmid:19323834 + pubmed:16820021 - p(FPLX:CEBP) partOf complex(p(FPLX:CEBP), p(HGNC:SUMO1)) + path(CONSO:"isolation rearing") decreases r(RGD:Ntrk2) - pmid:19323834 + pubmed:16820021 - p(HGNC:UBE2I) directlyDecreases r(HGNC:NOS2) + path(CONSO:"isolation rearing") increases r(RGD:Ntrk2) - pmid:18675254 + pubmed:16820021 - p(HGNC:UBE2I) association complex(GO:"endoplasmic reticulum") + path(CONSO:"isolation rearing") regulates p(RGD:Ntrk2) + + - pmid:19323834 + pubmed:22530628 - p(HGNC:SENP1) directlyDecreases r(HGNC:NOS2) + path(MESH:"Memory Disorders") positiveCorrelation a(CHEBI:amyloid-beta) - pmid:18675254 + pubmed:22530628 - p(HGNC:APP, pmod(Sumo, Lys, 587)) negativeCorrelation a(CHEBI:"amyloid-beta") + path(MESH:"Memory Disorders") negativeCorrelation act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) - pmid:18675254 + pubmed:18986241 - p(HGNC:APP, pmod(Sumo, Lys, 595)) negativeCorrelation a(CHEBI:"amyloid-beta") + path(MESH:"Memory Disorders") association path(CONSO:aMCI) - pmid:18675254 + pubmed:22530628 - p(HGNC:SUMO2) increases p(HGNC:APP, pmod(Sumo, Lys, 587)) + path(MESH:"Tobacco Use") negativeCorrelation path(DOID:"Alzheimer's disease") - pmid:18675254 + pubmed:21482353 - p(HGNC:SUMO2) increases p(HGNC:APP, pmod(Sumo, Lys, 595)) + path(MESH:"Tobacco Use") decreases path(MESH:"Parkinson Disease") - pmid:18675254 + pubmed:22530628 - complex(GO:"endoplasmic reticulum") association p(HGNC:UBE2I) + complex(a(CHEBI:amyloid-beta), a(CHEBI:nicotine)) decreases a(CONSO:"amyloid-beta aggregates") - pmid:17346237 + pubmed:22530628 - p(HGNC:SUMO3) increases p(HGNC:BACE1) + complex(a(CHEBI:amyloid-beta), a(CHEBI:nicotine)) decreases a(CONSO:"amyloid-beta fibrils") - pmid:17346237 + pubmed:22530628 - p(HGNC:SUMO3) increases p(HGNC:APP) + complex(a(CHEBI:amyloid-beta), a(CHEBI:nicotine)) increases bp(MESH:Neuroprotection) - pmid:17346237 + pubmed:22530628 - p(HGNC:SUMO3) increases sec(p(HGNC:APP, frag("672_711"))) + a(MESH:Cotinine) decreases path(MESH:"Memory Disorders") - pmid:17346237 + pubmed:22530628 - p(HGNC:SUMO3) increases sec(p(HGNC:APP, frag("672_713"))) + a(MESH:Cotinine) decreases a(CONSO:"amyloid-beta aggregates") - pmid:12506199 + pubmed:22530628 - p(HGNC:SUMO3) decreases a(CHEBI:"amyloid-beta") + a(MESH:Cotinine) decreases a(CONSO:"amyloid-beta aggregates") + + + pubmed:22530628 + + a(MESH:Cotinine) decreases a(CONSO:"amyloid-beta aggregates") + + - pmid:12506199 + pubmed:22530628 - p(HGNC:SUMO3) increases p(HGNC:APP, pmod(HBP:polysumoylation)) + a(MESH:Cotinine) decreases path(MESH:"Plaque, Amyloid") - pmid:16464864 + pubmed:22530628 - a(CHEBI:colchicine) increases p(HGNC:MAPT, pmod(Sumo, Lys, 340)) + a(MESH:Cotinine) decreases path(MESH:"Plaque, Amyloid") - pmid:12506199 + pubmed:22530628 - p(HGNC:SUMO3, var("p.Lys11Arg")) increases p(HGNC:APP, pmod(Sumo)) + a(MESH:Cotinine) increases a(PUBCHEM:10219774) - pmid:12506199 + pubmed:22530628 - p(HGNC:SUMO3, var("p.Lys11Arg")) increases a(CHEBI:"amyloid-beta") + a(MESH:Cotinine) increases a(MESH:"cotinine N-glucuronide") - pmid:12506199 + pubmed:22530628 - p(HGNC:APP, pmod(Sumo)) increases a(CHEBI:"amyloid-beta") + a(MESH:Cotinine) increases bp(GO:"learning or memory") - pmid:12506199 + pubmed:22530628 - p(HGNC:APP, pmod(HBP:polysumoylation)) decreases a(CHEBI:"amyloid-beta") + a(MESH:Cotinine) decreases path(HP:Anxiety) - pmid:29334120 + pubmed:22530628 - p(HGNC:PPP1CC) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 403)) + a(MESH:Cotinine) decreases path(MESH:Fear) - pmid:29334120 + pubmed:22530628 - p(HGNC:PPP1CC) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 404)) + a(MESH:Cotinine) increases bp(GO:cognition) - pmid:29334120 + pubmed:22530628 - p(HGNC:PPP1CC) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 409)) + a(MESH:Cotinine) decreases a(CONSO:"amyloid-beta oligomers") - pmid:29334120 + pubmed:22530628 - p(HGNC:PPP1CC) directlyDecreases p(HGNC:TARDBP, pmod(Ph, Ser, 410)) + a(MESH:Cotinine) increases act(p(HGNC:AKT1)) - pmid:29334120 + pubmed:22530628 - p(HGNC:TARDBP, pmod(Ph, Ser, 409)) increases act(p(HGNC:TARDBP)) + a(MESH:Cotinine) increases act(p(HGNC:AKT1)) - pmid:29334120 + pubmed:22530628 - p(HGNC:TARDBP, pmod(Ph, Ser, 410)) increases act(p(HGNC:TARDBP)) + a(MESH:Cotinine) increases act(p(HGNC:GSK3B)) - pmid:26142647 + pubmed:22530628 - p(HGNC:PPP1R15A) regulates act(p(HGNC:PPP1CA)) + a(MESH:Cotinine) increases act(p(HGNC:GSK3B)) - + + + pubmed:22530628 + + a(MESH:Cotinine) decreases p(HGNC:GSK3B) + - pmid:29228318 + pubmed:22530628 - complex(p(HGNC:PPP2CA), p(HGNC:PPP2CB)) decreases deg(p(HGNC:PPP2CB)) + a(MESH:Cotinine) increases p(HGNC:CHRNA7) - pmid:29228318 + pubmed:22530628 - complex(p(HGNC:PPP2CA), p(HGNC:PPP2CB)) increases complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2CB)) + a(MESH:Cotinine) increases act(p(HGNC:CHRNA7)) - + + + pubmed:22530628 + + a(MESH:Cotinine) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + pubmed:22530628 + + a(MESH:Cotinine) decreases p(MESH:"Neurofibrillary Tangles") + + - pmid:29228318 + pubmed:22530628 - complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2CB)) decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + a(MESH:Cotinine) increases act(p(HGNC:CREBBP)) - pmid:29228318 + pubmed:22530628 - complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2CB)) decreases a(HBP:"paired helical filaments") + a(MESH:Cotinine) increases act(p(HGNC:MAPK3)) - pmid:29228318 + pubmed:22530628 - complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2CB)) decreases a(MESH:Axons) + a(MESH:Cotinine) increases act(p(HGNC:MAPK1)) - pmid:29228318 + pubmed:22530628 - complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2CB)) decreases bp(GO:"cell death") + composite(a(CHEBI:nicotine), p(HGNC:CYP2A6)) increases a(MESH:Cotinine) - - - pmid:29421605 - - p(RGD:Ptpn1) positiveCorrelation bp(GO:aging) - + - pmid:29421605 + pubmed:22530628 - p(RGD:Irs1, pmod(Ph)) negativeCorrelation bp(GO:aging) + composite(a(CHEBI:nicotine), p(NCIT:C18024)) increases a(MESH:Cotinine) + + - pmid:29421605 + pubmed:21482353 - p(RGD:Akt1, pmod(Ph)) negativeCorrelation bp(GO:aging) + path(MESH:Fear) increases a(CHEBI:dopamine) - - - pmid:29421605 + pubmed:29428175 - p(RGD:Mtor, pmod(Ph)) negativeCorrelation bp(GO:aging) + bp(MESH:"Long-Term Potentiation") positiveCorrelation bp(GO:"glutamate secretion") + + + pubmed:27796283 + + bp(MESH:"Long-Term Potentiation") association p(HGNC:CAMKV) + + - pmid:29421605 + pubmed:22530628 - p(RGD:Ntrk2, pmod(Ph)) negativeCorrelation bp(GO:aging) + complex(CONSO:"alpha-4 beta-2 nAChR") increases bp(GO:"learning or memory") + + + pubmed:22530628 + + complex(CONSO:"alpha-4 beta-2 nAChR") increases path(MESH:Attention) + + - pmid:29062069 + pubmed:22530628 - p(HGNC:MID1) decreases act(p(HGNC:PPP2CA)) + complex(CONSO:"alpha-4 beta-2 nAChR") increases bp(GO:cognition) - pmid:29062069 + pubmed:24762290 - p(HGNC:MID1) positiveCorrelation path(MESH:"Alzheimer Disease") + complex(CONSO:"alpha-4 beta-2 nAChR") association a(MESH:Thalamus) - pmid:28422052 + pubmed:24762290 - a(CHEBI:"folic acid") decreases p(MGI:Mapt, pmod(Ph, Ser, 396)) + complex(CONSO:"alpha-4 beta-2 nAChR") association a(MESH:Thalamus) - pmid:28422052 + pubmed:24762290 - a(CHEBI:"folic acid") increases r(MGI:Dnmt1) + complex(CONSO:"alpha-4 beta-2 nAChR") association a(MESH:Pons) - pmid:28422052 + pubmed:24762290 - a(CHEBI:"folic acid") increases p(FPLX:PPP2, pmod(Me)) + complex(CONSO:"alpha-4 beta-2 nAChR") association a(MESH:Mesencephalon) - pmid:25143394 + pubmed:24762290 - p(MGI:Ppp1ca) negativeCorrelation p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) + complex(CONSO:"alpha-4 beta-2 nAChR") association a(MESH:"Corpus Striatum") - pmid:25143394 + pubmed:24762290 - p(MGI:Ppp1cb) negativeCorrelation p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) + complex(CONSO:"alpha-4 beta-2 nAChR") positiveCorrelation a(MESH:"White Matter") - pmid:23134599 + pubmed:24762290 - a(CHEBI:"lead diacetate") decreases p(RGD:Ppp2ca) + complex(CONSO:"alpha-4 beta-2 nAChR") association path(MESH:"Parkinson Disease") - pmid:23134599 + pubmed:24762290 - a(CHEBI:"lead diacetate") increases p(RGD:Ppp1ca) + complex(CONSO:"alpha-4 beta-2 nAChR") association a(MESH:"Parietal Lobe") - pmid:23134599 + pubmed:24762290 - a(CHEBI:"lead diacetate") increases p(RGD:Ppp5c) + complex(CONSO:"alpha-4 beta-2 nAChR") association path(MESH:Memory) - pmid:23134599 + pubmed:19721446 - a(CHEBI:"lead diacetate") increases p(MGI:Mapt, pmod(HBP:hyperphosphorylation)) + bp(MESH:"Sensory Gating") association path(MESH:Schizophrenia) - pmid:21489990 + pubmed:19721446 - p(RGD:Egr1) increases act(p(RGD:Cdk5)) + bp(MESH:"Sensory Gating") association p(HGNC:CHRNA7) - pmid:21489990 + pubmed:22530628 - p(RGD:Egr1) increases p(FPLX:PPP1, pmod(Ph)) + a(DRUGBANK:GTS-21) increases bp(GO:cognition) - pmid:21489990 + pubmed:22530628 - p(FPLX:PPP1, pmod(Ph)) decreases act(p(FPLX:PPP1)) + a(MESH:"3-(4-dimethylaminobenzylidene)anabaseine") increases bp(GO:cognition) - pmid:19623258 + pubmed:22530628 - act(complex(GO:"NMDA selective glutamate receptor complex")) increases p(HGNC:MAPT, pmod(Ph, Ser, 199)) + p(HGNC:DBF4) decreases p(HGNC:MAP3K5) - pmid:19623258 + pubmed:22530628 - act(complex(GO:"NMDA selective glutamate receptor complex")) increases p(HGNC:MAPT, pmod(Ph, Ser, 202)) + p(HGNC:PIK3CA) increases bp(MESH:"Neuronal Plasticity") - pmid:19623258 + pubmed:22530628 - act(complex(GO:"NMDA selective glutamate receptor complex")) increases p(HGNC:MAPT, pmod(Ph, Thr, 231)) + p(HGNC:PIK3CA) increases bp(GO:cognition) - pmid:25001178 + pubmed:22530628 - p(HGNC:DUSP6) directlyDecreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + p(HGNC:PIK3CA) increases bp(GO:"learning or memory") - pmid:25001178 + pubmed:22530628 - p(HGNC:DUSP6) negativeCorrelation path(MESH:"Alzheimer Disease") + p(HGNC:PIK3CA) increases p(HGNC:AKT1, pmod(go:0006468 ! "protein phosphorylation", Thr, 308)) - pmid:25001178 + pubmed:22530628 - p(HGNC:DUSP6) decreases p(FPLX:ERK) + p(HGNC:PIK3CA) increases p(HGNC:AKT1, pmod(go:0006468 ! "protein phosphorylation", Ser, 473)) - pmid:25001178 + pubmed:30697142 - p(HGNC:BCL2L2) decreases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) + p(HGNC:PIK3CA) increases p(FPLX:AKT, pmod(go:0006468 ! "protein phosphorylation")) @@ -161862,657 +163092,682 @@

Statements

+ + - pmid:24964035 + pubmed:18467332 - p(FPLX:SMAD) decreases p(HGNC:PIN1) + p(HGNC:PIK3R1) isA complex(p(HGNC:MAPT), p(HGNC:PIK3R1)) - pmid:24964035 + pubmed:22530628 - p(FPLX:SMAD) negativeCorrelation path(MESH:"Alzheimer Disease") + complex(p(HGNC:FYN), p(HGNC:PIK3R1)) increases act(p(HGNC:PIK3CA)) - pmid:22926167 + pubmed:22530628 - p(HGNC:PIN1, pmod(Ph, Ser, 16)) decreases p(HGNC:PIN1) + act(p(HGNC:AKT1, pmod(go:0006468 ! "protein phosphorylation", Thr, 308))) increases act(p(HGNC:BCL2)) - pmid:22926167 + pubmed:22530628 - p(HGNC:PIN1, pmod(Ph, Ser, 16)) decreases p(HGNC:PIN1, loc(MESH:"Cell Nucleus")) + act(p(HGNC:AKT1, pmod(go:0006468 ! "protein phosphorylation", Thr, 308))) increases act(p(HGNC:CREBBP)) - pmid:22926167 + pubmed:22530628 - p(HGNC:PIN1, pmod(Ph, Ser, 65)) decreases p(HGNC:PIN1) + act(p(HGNC:AKT1, pmod(go:0006468 ! "protein phosphorylation", Thr, 308))) increases p(HGNC:MAP3K5, pmod(go:0006468 ! "protein phosphorylation", Ser, 83)) - pmid:22926167 + pubmed:22530628 - p(HGNC:PIN1, pmod(Ph, Ser, 65)) causesNoChange p(HGNC:PIN1, loc(MESH:"Cell Nucleus")) + act(p(HGNC:AKT1, pmod(go:0006468 ! "protein phosphorylation", Thr, 308))) decreases act(p(HGNC:MAP3K5)) - pmid:22926167 + pubmed:22530628 - p(HGNC:PIN1, pmod(Ph, Ser, 65)) decreases p(HGNC:PIN1, pmod(Ub)) + act(p(HGNC:AKT1, pmod(go:0006468 ! "protein phosphorylation", Ser, 473))) increases act(p(HGNC:BCL2)) - pmid:22926167 + pubmed:22530628 - p(HGNC:PIN1, pmod(Ac, Lys, 46)) decreases p(HGNC:PIN1) + act(p(HGNC:AKT1, pmod(go:0006468 ! "protein phosphorylation", Ser, 473))) increases act(p(HGNC:CREBBP)) - - - pmid:22926167 + pubmed:22530628 - complex(p(HGNC:MAPT, pmod(Ph, Thr, 231)), p(HGNC:PIN1)) decreases p(HGNC:MAPT, pmod(Ph, Thr, 231)) + act(p(HGNC:AKT1, pmod(go:0006468 ! "protein phosphorylation", Ser, 473))) increases p(HGNC:MAP3K5, pmod(go:0006468 ! "protein phosphorylation", Ser, 83)) - - - pmid:22926167 + pubmed:22530628 - p(HGNC:PIN1, pmod(Ub)) increases deg(p(HGNC:PIN1)) + act(p(HGNC:AKT1, pmod(go:0006468 ! "protein phosphorylation", Ser, 473))) decreases act(p(HGNC:MAP3K5)) - pmid:27181519 + pubmed:22530628 - path(MESH:"Motor Neuron Disease") negativeCorrelation bp(GO:autophagy) + p(HGNC:MAP3K5, pmod(go:0006468 ! "protein phosphorylation", Ser, 83)) decreases act(p(HGNC:MAP3K5)) - pmid:27181519 + pubmed:22530628 - path(MESH:"Motor Neuron Disease") negativeCorrelation act(p(HGNC:TARDBP)) + p(HGNC:ARC) increases bp(GO:"learning or memory") - pmid:27181519 + pubmed:22530628 - bp(GO:"muscle atrophy") positiveCorrelation bp(GO:"motor neuron apoptotic process") + p(HGNC:ARC) increases bp(MESH:"Neuronal Plasticity") - pmid:27181519 + pubmed:22908190 - act(a(MESH:"Respiratory Muscles")) decreases path(MESH:Death) + p(HGNC:ARC) regulates bp(GO:"synapse maturation") - pmid:27181519 + pubmed:22530628 - bp(GO:"RNA processing") association complex(GO:"ribonucleoprotein granule") + p(HGNC:ACR) increases bp(GO:"learning or memory") - pmid:27181519 + pubmed:22530628 - complex(GO:"cytoplasmic stress granule") isA complex(GO:"ribonucleoprotein granule") + bp(MESH:"Serum Response Element") increases p(HGNC:ARC) - pmid:27181519 + pubmed:22530628 - complex(GO:"cytoplasmic stress granule") regulates a(MESH:"RNA, Messenger") + p(HGNC:EEF2) increases p(HGNC:ARC) - pmid:27181519 + pubmed:22530628 - complex(GO:"cytoplasmic stress granule") negativeCorrelation bp(GO:translation) + r(HGNC:ARC) positiveCorrelation p(HGNC:CHRNA7) - pmid:27181519 + pubmed:22530628 - complex(GO:"cytoplasmic stress granule") negativeCorrelation act(complex(GO:"proteasome complex")) + a(DRUGBANK:"1-Anilino-8-Naphthalene Sulfonate") causesNoChange a(CONSO:"amyloid-beta oligomers") - pmid:27181519 + pubmed:22530628 - complex(GO:"cytoplasmic stress granule") decreases bp(MESH:"Unfolded Protein Response") + a(DRUGBANK:"1-Anilino-8-Naphthalene Sulfonate") decreases a(CONSO:"amyloid-beta fibrils") - pmid:27181519 + pubmed:26813123 - complex(GO:"cytoplasmic stress granule", loc(MESH:"Motor Neurons")) positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") + bp(GO:"response to stress") association bp(GO:"synaptic transmission, cholinergic") - pmid:27181519 + pubmed:26813123 - complex(GO:"cytoplasmic stress granule") association p(HGNC:FUS, loc(GO:cytosol)) + bp(GO:"response to stress") regulates tloc(a(CHEBI:acetylcholine), fromLoc(GO:intracellular), toLoc(MESH:"Basal Forebrain")) - pmid:27181519 + pubmed:24563850 - complex(GO:"cytoplasmic stress granule") association p(HGNC:TARDBP, loc(GO:cytosol)) + bp(GO:"response to stress") increases p(HGNCGENEFAMILY:"Small heat shock proteins") - pmid:27181519 + pubmed:24563850 - complex(GO:"cytoplasmic stress granule") association p(INTERPRO:"Prion/Doppel protein, beta-ribbon domain") + bp(GO:"response to stress") increases p(HGNC:HSF1, pmod(go:0006468 ! "protein phosphorylation")) - pmid:27181519 + pubmed:24563850 - complex(GO:"cytoplasmic stress granule") positiveCorrelation g(HGNC:C9orf72) + bp(GO:"response to stress") increases complex(p(HGNC:HSF1), p(HGNC:HSF1), p(HGNC:HSF1)) - pmid:27181519 + pubmed:24563850 - complex(GO:"cytoplasmic stress granule", loc(GO:autophagosome)) increases bp(GO:"stress granule disassembly") + bp(GO:"response to stress") increases p(HGNC:HSF1, loc(MESH:"Cell Nucleus")) - pmid:27181519 + pubmed:24563850 - complex(GO:"cytoplasmic stress granule") association p(HGNC:G3BP1) + bp(GO:"response to stress") increases act(p(HGNC:HSF1), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) - pmid:27181519 + pubmed:27181519 - bp(GO:"RNA catabolic process") association complex(GO:"P-body") + bp(GO:"response to stress") increases p(HGNC:HDAC6, loc(GO:"cytoplasmic stress granule")) - pmid:27181519 + pubmed:30988501 - a(MESH:Viruses) increases complex(GO:"cytoplasmic stress granule") + bp(GO:"response to stress") increases act(complex(MESH:Inflammasomes)) - pmid:24561250 + pubmed:30988501 - a(MESH:Viruses) increases act(complex(GO:"inflammasome complex")) + bp(GO:"response to stress") increases path(MESH:Recurrence) - - - - - pmid:27181519 + pubmed:26813123 - complex(a(GO:"cytoplasmic stress granule"), a(MESH:"RNA, Messenger")) decreases bp(GO:translation) + bp(GO:"regulation of circadian sleep/wake cycle, wakefulness") association bp(GO:"synaptic transmission, cholinergic") - pmid:27181519 + pubmed:26813123 - p(HGNC:TIA1) increases complex(GO:"cytoplasmic stress granule") + bp(GO:"regulation of circadian sleep/wake cycle, sleep") association bp(GO:"synaptic transmission, cholinergic") - pmid:27181519 + pubmed:24590577 - a(CHEBI:"autophagy inhibitor") decreases deg(complex(GO:"cytoplasmic stress granule")) + bp(GO:"circadian sleep/wake cycle") association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") - pmid:27181519 + pubmed:26813123 - g(HGNC:SOD1) association path(MESH:"Amyotrophic Lateral Sclerosis") + p(HGNC:SLC18A3) increases tloc(a(CHEBI:acetylcholine), fromLoc(GO:cytosol), toLoc(MESH:"Synaptic Vesicles")) - pmid:27181519 + pubmed:26813123 - p(HGNC:FUS, var("?")) increases path(MESH:"Amyotrophic Lateral Sclerosis") + p(HGNC:SLC18A3) increases tloc(a(CHEBI:acetylcholine), fromLoc(GO:cytosol), toLoc(MESH:"Synaptic Vesicles")) - pmid:27181519 + pubmed:26813123 - p(HGNC:FUS, var("?")) positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") + p(HGNC:SLC18A3) increases tloc(a(CHEBI:proton), fromLoc(MESH:"Synaptic Vesicles"), toLoc(GO:cytosol)) + + - pmid:27181519 + pubmed:26813123 - p(HGNC:FUS, var("?")) decreases bp(GO:autophagy) + p(HGNC:CHAT, pmod(go:0006468 ! "protein phosphorylation")) regulates act(p(HGNC:CHAT)) - pmid:27181519 + pubmed:26813123 - p(HGNC:FUS, var("?")) decreases bp(GO:autophagy) + a(CHEBI:"2-(4-phenyl-1-piperidinyl)-1-cyclohexanol") decreases act(p(HGNC:SLC18A3)) - pmid:27181519 + pubmed:26813123 - p(HGNC:FUS, var("?")) decreases bp(GO:"motor neuron apoptotic process") + a(CHEBI:"2-(4-phenyl-1-piperidinyl)-1-cyclohexanol") decreases tloc(a(CHEBI:acetylcholine), fromLoc(GO:cytosol), toLoc(MESH:"Synaptic Vesicles")) - pmid:27181519 + pubmed:26813123 - p(HGNC:FUS, var("?")) increases bp(GO:"cell death") + p(MGI:Slc18a3) decreases path(MESH:"Neuromuscular Diseases") - pmid:27181519 + pubmed:26813123 - p(HGNC:FUS, var("?")) decreases a(MESH:Neurites) + p(MGI:Slc18a3) increases bp(GO:cognition) - pmid:27181519 + pubmed:26813123 - p(HGNC:TARDBP, var("?")) increases path(MESH:"Amyotrophic Lateral Sclerosis") + a(CHEBI:"organophosphorus compound") decreases act(p(HGNC:ACHE)) - pmid:27181519 + pubmed:26813123 - p(HGNC:TARDBP, var("?")) positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") + a(CHEBI:antidote) increases act(p(HGNC:ACHE)) - pmid:27181519 + pubmed:26813123 - p(HGNC:TARDBP, var("?")) decreases bp(GO:autophagy) + a(CHEBI:doxylamine) increases act(p(HGNC:ACHE)) - pmid:27181519 + pubmed:26813123 - bp(GO:"RNA splicing") association p(HGNC:FUS) + a(CHEBI:succinylcholine) decreases act(p(HGNC:ACHE)) - pmid:27181519 + pubmed:26813123 - bp(GO:"RNA splicing") association p(HGNC:TARDBP) + p(MGI:Slc5a7) decreases path(MESH:Death) - pmid:27181519 + pubmed:26813123 - p(HGNC:FUS, pmod(Me)) increases p(HGNC:FUS, loc(GO:cytoplasm)) + complex(a(GO:"plasma membrane"), p(HGNC:SLC5A7)) association bp(GO:"action potential initiation") + + - pmid:27181519 + pubmed:26813123 - p(HGNC:FUS, pmod(Ph)) increases p(HGNC:FUS, loc(GO:cytoplasm)) + a(MESH:"Basal Nucleus of Meynert") negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:27181519 + pubmed:26813123 - p(INTERPRO:"Prion/Doppel protein, beta-ribbon domain") association complex(GO:"cytoplasmic stress granule") + p(FPLX:CHRN, pmod(go:0006468 ! "protein phosphorylation")) regulates act(p(FPLX:CHRN)) - pmid:27181519 + pubmed:26813123 - p(HGNC:MATR3) association path(MESH:"Amyotrophic Lateral Sclerosis") + a(MESH:"Protein-Tyrosine Kinases") increases p(FPLX:CHRN, pmod(go:0006468 ! "protein phosphorylation")) - pmid:27181519 + pubmed:26813123 - p(HGNC:HNRNPA2B1) association path(MESH:"Amyotrophic Lateral Sclerosis") + complex(a(CHEBI:"1,1-dimethyl-4-phenylpiperazinium iodide"), p(FPLX:CHRN)) increases act(p(FPLX:CHRN)) - pmid:27181519 + pubmed:26813123 - p(HGNC:HNRNPA1) association path(MESH:"Amyotrophic Lateral Sclerosis") + complex(a(CHEBI:cystine), p(FPLX:CHRN)) increases act(p(FPLX:CHRN)) - - - + + + pubmed:22020111 + + a(CHEBI:cystine) increases a(CHEBI:glutathione) + - pmid:27181519 + pubmed:26813123 - g(HGNC:C9orf72, var("?")) association path(MESH:"Amyotrophic Lateral Sclerosis") + complex(a(CHEBI:nicotine), p(FPLX:CHRN)) increases act(p(FPLX:CHRN)) - - - pmid:27181519 + pubmed:11230871 - g(HGNC:C9orf72) association p(HGNC:RAB1A) + complex(a(CHEBI:nicotine), p(FPLX:CHRN)) association bp(GO:cognition) - pmid:27181519 + pubmed:26813123 - g(HGNC:C9orf72) association p(HGNC:RAB1B) + a(CHEBI:tubocurarine) decreases act(p(FPLX:CHRN)) - pmid:27181519 + pubmed:29626319 - g(HGNC:C9orf72) association p(HGNC:RAB5A) + a(MESH:"Receptors, G-Protein-Coupled") increases deg(a(CHEBI:amyloid-beta)) - pmid:27181519 + pubmed:26813123 - g(HGNC:C9orf72) association p(HGNC:RAB7A) + complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) increases act(p(FPLX:PLC)) - pmid:27181519 + pubmed:26813123 - g(HGNC:C9orf72) association p(HGNC:RAB11A) + complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(CHEBI:myo-inositol) - pmid:27181519 + pubmed:26813123 - g(HGNC:C9orf72) association p(HGNC:RAB11B) + complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) decreases act(a(MESH:"Potassium Channels")) - pmid:27181519 + pubmed:26813123 - g(HGNC:C9orf72) increases act(a(GO:autophagosome)) + complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(MESH:"Receptors, N-Methyl-D-Aspartate") - pmid:27181519 + pubmed:26813123 - g(HGNC:C9orf72) positiveCorrelation act(p(HGNC:NTRK2)) + complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) negativeCorrelation path(MESH:"Alzheimer Disease") - pmid:27181519 + pubmed:26813123 - g(HGNC:C9orf72) positiveCorrelation act(p(HGNC:MAP1LC3A)) + complex(p(HGNC:CHRM1), p(INTERPRO:"G-protein alpha subunit, group Q")) increases bp(GO:cognition) + + + + + + - pmid:27181519 + pubmed:26813123 - g(HGNC:C9orf72) positiveCorrelation complex(GO:"cytoplasmic stress granule") + complex(p(HGNC:CHRM3), p(INTERPRO:"G-protein alpha subunit, group Q")) increases act(p(FPLX:PLC)) - pmid:27181519 + pubmed:26813123 - p(HGNC:RAB1B) association g(HGNC:C9orf72) + complex(p(HGNC:CHRM3), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(CHEBI:myo-inositol) - pmid:27181519 + pubmed:26813123 - p(HGNC:RAB11B) association g(HGNC:C9orf72) + complex(p(HGNC:CHRM3), p(INTERPRO:"G-protein alpha subunit, group Q")) decreases act(a(MESH:"Potassium Channels")) - pmid:27181519 + pubmed:26813123 - act(p(HGNC:NTRK2)) positiveCorrelation g(HGNC:C9orf72) + complex(p(HGNC:CHRM3), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(MESH:"Receptors, N-Methyl-D-Aspartate") - + + + pubmed:26813123 + + complex(p(HGNC:CHRM5), p(INTERPRO:"G-protein alpha subunit, group Q")) increases act(p(FPLX:PLC)) + - + + + pubmed:26813123 + + complex(p(HGNC:CHRM5), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(CHEBI:myo-inositol) + - + + + pubmed:26813123 + + complex(p(HGNC:CHRM5), p(INTERPRO:"G-protein alpha subunit, group Q")) decreases act(a(MESH:"Potassium Channels")) + - pmid:27181519 + pubmed:26813123 - bp(GO:"stress granule assembly") negativeCorrelation p(MESH:Proteins, pmod(Ub)) + complex(p(HGNC:CHRM5), p(INTERPRO:"G-protein alpha subunit, group Q")) increases a(MESH:"Receptors, N-Methyl-D-Aspartate") - + + + pubmed:26813123 + + complex(p(HGNC:CHRM2), p(INTERPRO:"G-protein alpha subunit, group I")) decreases p(FPLX:ADCY) + - pmid:27181519 + pubmed:26813123 - complex(p(HGNC:MAP1LC3A), p(HGNC:OPTN)) association bp(GO:autophagy) + complex(p(HGNC:CHRM2), p(INTERPRO:"G-protein alpha subunit, group I")) decreases a(CHEBI:"3',5'-cyclic AMP") - pmid:27181519 + pubmed:26813123 - complex(p(HGNC:MAP1LC3A), p(HGNC:OPTN)) increases bp(GO:mitophagy) + complex(p(HGNC:CHRM2), p(INTERPRO:"G-protein alpha subunit, group I")) decreases act(a(MESH:"Calcium Channels")) @@ -162523,27 +163778,27 @@

Statements

- pmid:27181519 + pubmed:26813123 - p(HGNC:OPTN, var("p.Glu478Gly")) association path(MESH:"Amyotrophic Lateral Sclerosis") + complex(p(HGNC:CHRM4), p(INTERPRO:"G-protein alpha subunit, group I")) decreases p(FPLX:ADCY) - pmid:27181519 + pubmed:26813123 - p(HGNC:OPTN, var("p.Glu478Gly")) increases complex(p(HGNC:OPTN), p(HGNC:OPTN, var("p.Glu478Gly"))) + complex(p(HGNC:CHRM4), p(INTERPRO:"G-protein alpha subunit, group I")) decreases a(CHEBI:"3',5'-cyclic AMP") - pmid:27181519 + pubmed:26813123 - p(HGNC:OPTN, var("p.Glu478Gly")) decreases complex(a(MESH:Ubiquitin), p(HGNC:OPTN)) + complex(p(HGNC:CHRM4), p(INTERPRO:"G-protein alpha subunit, group I")) decreases act(a(MESH:"Calcium Channels")) @@ -162552,1640 +163807,1860 @@

Statements

- pmid:27181519 + pubmed:26088141 - complex(p(HGNC:OPTN), p(HGNC:OPTN, var("p.Glu478Gly"))) decreases act(p(HGNC:OPTN)) + act(a(MESH:"Calcium Channels")) association act(a(CHEBI:choline)) - - - pmid:27181519 + pubmed:26088141 - complex(p(HGNC:OPTN), p(HGNC:OPTN, var("p.Glu478Gly"))) decreases complex(a(GO:autophagosome), p(HGNC:OPTN)) + act(a(MESH:"Calcium Channels")) association a(CHEBI:"calcium(2+)") - pmid:27181519 + pubmed:26813123 - complex(p(HGNC:OPTN), p(HGNC:OPTN, var("p.Glu478Gly"))) decreases bp(GO:autophagy) + complex(a(CHEBI:Muscarine), p(FPLX:CHRM)) increases act(p(FPLX:CHRM)) - pmid:27181519 + pubmed:26813123 - complex(p(HGNC:OPTN), p(HGNC:OPTN, var("p.Glu478Gly"))) decreases bp(GO:autophagy) + a(MESH:"Quinuclidinyl Benzilate") decreases act(p(FPLX:CHRM)) - pmid:27181519 + pubmed:26813123 - complex(p(HGNC:OPTN), p(HGNC:OPTN, var("p.Glu478Gly"))) increases a(HBP:"protein aggregates", loc(MESH:Cytosol)) + a(MESH:"Receptors, Cholinergic") increases bp(GO:memory) - - - - - - - - - pmid:27181519 + pubmed:25514383 - path(MESH:"Liver Diseases") association p(HGNC:TBK1) + a(MESH:"Receptors, Cholinergic") increases path(MESH:Attention) - pmid:27181519 + pubmed:26813123 - p(HGNC:OPTN, pmod(Ph)) increases bp(GO:autophagy) + path(MESH:Apathy) positiveCorrelation path(MESH:"Alzheimer Disease") - - - - - pmid:27181519 + pubmed:26813123 - complex(p(HGNC:OPTN), p(HGNC:TBK1)) association a(HBP:"protein aggregates") + p(MGI:Chrm4) decreases tloc(a(CHEBI:dopamine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) - pmid:27181519 + pubmed:24590577 - p(HGNC:OPTN, pmod(Ph, Ser, 177)) regulates deg(a(HBP:"protein aggregates")) + p(MGI:Chrm4) decreases act(a(CHEBI:phencyclidine)) - pmid:27181519 + pubmed:24590577 - p(HGNC:OPTN, pmod(Ph, Ser, 177)) regulates bp(GO:autophagy) + p(MGI:Chrm4) decreases bp(GO:"locomotor rhythm") - pmid:27181519 + pubmed:24590577 - path(MESH:"Glaucoma, Open-Angle") association p(HGNC:OPTN, var("p.Glu50Lys")) + p(MGI:Chrm4) decreases act(p(MGI:Drd1)) - pmid:27181519 + pubmed:26813123 - p(HGNC:OPTN, var("p.Glu50Lys")) association path(MESH:"Glaucoma, Open-Angle") + path(MESH:"Amyotrophic Lateral Sclerosis") negativeCorrelation a(MESH:"Cholinergic Neurons") - pmid:27181519 + pubmed:22020111 - p(HGNC:OPTN, var("p.Glu50Lys")) increases complex(p(HGNC:OPTN), p(HGNC:TBK1)) + path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation a(CONSO:"protein aggregates") - pmid:27181519 + pubmed:30688256 - p(HGNC:UBQLN2, var("?")) association path(MESH:"Amyotrophic Lateral Sclerosis") + path(MESH:"Amyotrophic Lateral Sclerosis") negativeCorrelation bp(GO:mitophagy) - - - pmid:27181519 + pubmed:30688256 - p(HGNC:UBQLN2) increases p(MESH:Proteins, pmod(Ub), loc(GO:"proteasome complex")) + path(MESH:"Amyotrophic Lateral Sclerosis") negativeCorrelation act(p(HGNCGENEFAMILY:"Miro like atypical Rho GTPases")) - pmid:27181519 + pubmed:30688256 - p(HGNC:UBQLN2) increases deg(p(MESH:Proteins, pmod(Ub))) + path(MESH:"Amyotrophic Lateral Sclerosis") negativeCorrelation p(HGNC:RHOT1) - pmid:27181519 + pubmed:30688256 - p(HGNC:UBQLN2) increases bp(GO:"autophagosome assembly") + path(MESH:"Amyotrophic Lateral Sclerosis") negativeCorrelation a(PUBCHEM:124886) - - - - - - - pmid:27181519 + pubmed:30688256 - complex(p(HGNC:HDAC6), p(HGNC:SQSTM1)) regulates act(p(HGNC:HDAC6), ma(GO:"protein deacetylation")) + path(MESH:"Amyotrophic Lateral Sclerosis") association a(CHEBI:"reactive oxygen species") - - - pmid:27181519 + pubmed:12428809 - p(HGNC:SQSTM1, var("?")) association path(MESH:"Amyotrophic Lateral Sclerosis") + path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation a(MESH:"Intermediate Filaments") - pmid:27181519 + pubmed:21722302 - a(CHEBI:"3-methyladenine") isA a(CHEBI:"autophagy inhibitor") + path(MESH:"Amyotrophic Lateral Sclerosis") association path(CONSO:Neurodegeneration) - pmid:27181519 + pubmed:21722302 - a(CHEBI:"3-methyladenine") decreases deg(p(HGNC:TARDBP)) + path(MESH:"Amyotrophic Lateral Sclerosis") association path(CONSO:Neurodegeneration) - pmid:26702100 + pubmed:21722302 - p(HGNC:RPS6KB1, pmod(Ph, Thr, 389)) negativeCorrelation act(p(HGNCGENEFAMILY:"MTOR complex 1")) + path(MESH:"Amyotrophic Lateral Sclerosis") association a(CONSO:"Motor Neurons") - - - pmid:26702100 + pubmed:21722302 - p(HGNC:RPS6KB1) association act(p(HGNCGENEFAMILY:"MTOR complex 1")) + path(MESH:"Amyotrophic Lateral Sclerosis") increases bp(CONSO:"protein aggregation") - - - pmid:26702100 + pubmed:21722302 - p(HGNC:RPTOR) regulates act(p(HGNC:MTOR)) + path(MESH:"Amyotrophic Lateral Sclerosis") association a(GO:"Bunina body") - pmid:26702100 + pubmed:21722302 - p(HGNC:RPTOR) increases p(HGNC:MTOR, loc(GO:lysosome)) + path(MESH:"Amyotrophic Lateral Sclerosis") association a(GO:"neurofilament cytoskeleton") - pmid:26702100 + pubmed:21722302 - p(HGNC:RPTOR) increases p(HGNC:MTOR) + path(MESH:"Amyotrophic Lateral Sclerosis") association a(CHEBI:ubiquitin) - pmid:26702100 + pubmed:21722302 - p(HGNC:RPTOR) regulates p(HGNC:MTOR) + path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:SOD1, var("?")) - pmid:26702100 + pubmed:21722302 - p(HGNC:RPTOR) increases tloc(p(HGNC:TFEB), fromLoc(GO:nucleus), toLoc(GO:nucleus)) + path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:SOD1, var("?")) - pmid:26702100 + pubmed:14556719 - p(HGNC:RRAGA) regulates act(p(HGNC:MTOR)) + path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:SOD1, var("?")) - pmid:26702100 + pubmed:21722302 - p(HGNC:RRAGA) increases p(HGNC:MTOR, loc(GO:lysosome)) + path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNCGENEFAMILY:"Protein disulfide isomerases") - pmid:26702100 + pubmed:21722302 - p(HGNC:RRAGA) increases p(HGNC:TFEB, loc(GO:lysosome)) + path(MESH:"Amyotrophic Lateral Sclerosis") association bp(GO:"ERAD pathway") - pmid:26702100 + pubmed:21722302 - complex(GO:"Ragulator complex") regulates act(p(HGNC:MTOR)) + path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:VAPB, var("?")) - - - - - - - pmid:26702100 + pubmed:21722302 - p(HGNC:LAMTOR1) increases p(HGNC:RRAGA, loc(GO:lysosome)) + path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:TARDBP) - pmid:26702100 + pubmed:30837838 - p(HGNC:LAMTOR1) increases p(HGNC:RRAGC, loc(GO:lysosome)) + path(MESH:"Amyotrophic Lateral Sclerosis") negativeCorrelation act(p(HGNC:TARDBP, loc(GO:nucleus))) - - - - - - - pmid:26702100 + pubmed:30837838 - complex(a(GO:"Ragulator complex"), p(HGNC:RRAGA), p(HGNCGENEFAMILY:"MTOR complex 1")) increases complex(a(GO:lysosome), p(HGNC:RRAGA)) + path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:TARDBP, loc(GO:"inclusion body")) - - - + + + pubmed:21722302 + + path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:ERN1) + - + + + pubmed:21722302 + + path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:EIF2AK3) + - + + + pubmed:21722302 + + path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:ATF6) + - + + + pubmed:25784053 + + path(MESH:"Amyotrophic Lateral Sclerosis") negativeCorrelation p(HGNC:ATF6) + - + + + pubmed:30740335 + + path(MESH:"Amyotrophic Lateral Sclerosis") increases deg(p(MESH:"Motor Neurons")) + - pmid:26702100 + pubmed:29758300 - p(HGNC:RRAGB) decreases p(HGNC:TFEB, loc(GO:nucleus)) + path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation p(HGNC:TARDBP, pmod(CONSO:misfolding)) - pmid:26702100 + pubmed:29758300 - p(HGNC:RRAGB) causesNoChange p(HGNC:TFEB, loc(GO:lysosome)) + path(MESH:"Amyotrophic Lateral Sclerosis") negativeCorrelation bp(GO:macroautophagy) - - - + + + pubmed:14556719 + + path(MESH:"Amyotrophic Lateral Sclerosis") decreases a(MESH:"Brain Stem") + - pmid:26702100 + pubmed:14556719 - p(HGNC:RHEB) increases act(p(HGNC:MTOR)) + path(MESH:"Amyotrophic Lateral Sclerosis") decreases bp(GO:"spinal cord development") - + + + pubmed:14556719 + + path(MESH:"Amyotrophic Lateral Sclerosis") decreases a(MESH:"Pyramidal Tracts") + - + + + pubmed:14556719 + + path(MESH:"Amyotrophic Lateral Sclerosis") increases path(MESH:Paralysis) + - + + + pubmed:14556719 + + path(MESH:"Amyotrophic Lateral Sclerosis") increases bp(GO:"neuron death") + - pmid:26702100 + pubmed:14556719 - p(HGNC:CD63) association a(GO:lysosome) + path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:RNF19A) - pmid:26702100 + pubmed:14556719 - p(HGNC:TFEB, var("p.Ser211Ala")) decreases p(HGNC:TFEB, pmod(Ph)) + path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation p(HGNC:UBL5) - pmid:26702100 + pubmed:22908190 - p(HGNC:TFEB, var("p.Ser211Ala")) decreases complex(p(HGNC:TFEB), p(HGNCGENEFAMILY:"14-3-3 phospho-serine/phospho-threonine binding proteins")) + path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination")) - + + + pubmed:22908190 + + path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination")) + - pmid:26702100 + pubmed:30837838 - p(HGNC:TFEB, var("p.1_30del")) decreases complex(a(GO:lysosome), p(HGNC:RRAGA), p(HGNC:TFEB)) + path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination")) - pmid:26702100 + pubmed:30837838 - p(HGNC:TFEB, var("p.1_30del")) decreases p(HGNC:TFEB, pmod(Ph, Ser, 211)) + path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination")) - pmid:26702100 + pubmed:25784053 - p(HGNC:TFEB, var("p.1_30del")) increases p(HGNC:TFEB, loc(GO:nucleus)) + path(MESH:"Amyotrophic Lateral Sclerosis") increases bp(GO:autophagy) - - - + + + pubmed:26702100 + + path(MESH:"Amyotrophic Lateral Sclerosis") association bp(GO:autophagy) + - pmid:26702100 + pubmed:30116051 - complex(a(GO:lysosome), p(HGNC:RRAGA), p(HGNC:TFEB)) increases p(HGNC:TFEB, pmod(Ph, Ser, 211)) + path(MESH:"Amyotrophic Lateral Sclerosis") association path(MESH:"Frontotemporal Dementia") - pmid:26702100 + pubmed:30116051 - p(HGNC:TFEB, var("p.Gln10Ala"), var("p.Lys11Ala")) decreases complex(a(GO:lysosome), p(HGNC:RRAGA), p(HGNC:TFEB)) + path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:SQSTM1) - pmid:26702100 + pubmed:30837838 - p(HGNC:TFEB, var("p.Gln10Ala"), var("p.Lys11Ala")) decreases p(HGNC:TFEB, pmod(Ph, Ser, 211)) + path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:SQSTM1, loc(GO:"inclusion body")) - pmid:26702100 + pubmed:30116051 - p(HGNC:TFEB, var("p.Gln10Ala"), var("p.Lys11Ala")) increases p(HGNC:TFEB, loc(GO:nucleus)) + path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:CHMP2B) - + + + pubmed:30116051 + + path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:TBK1) + - pmid:26702100 + pubmed:30837838 - p(HGNCGENEFAMILY:Cathepsins) association a(GO:lysosome) + path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:TBK1) - pmid:26702100 + pubmed:30116051 - p(HGNC:ATG9B) association bp(GO:autophagy) + path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:OPTN) - + + + pubmed:30837838 + + path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:OPTN) + - pmid:28019679 + pubmed:29980653 - bp(GO:"innate immune response") increases act(complex(GO:"NLRP3 inflammasome complex")) + path(MESH:"Amyotrophic Lateral Sclerosis") isA path(MESH:"Neurodegenerative Diseases") - pmid:28019679 + pubmed:29980653 - act(complex(GO:"NLRP3 inflammasome complex")) increases p(HGNC:IL18) + path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation p(HGNC:TARDBP, var("?")) - pmid:28019679 + pubmed:30837838 - act(complex(GO:"NLRP3 inflammasome complex")) increases p(HGNC:IL1B) + path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:TARDBP, var("?")) - pmid:28019679 + pubmed:30837838 - act(complex(GO:"NLRP3 inflammasome complex")) increases p(HGNC:IL1B) + path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:SOD1) - pmid:24561250 + pubmed:30837838 - complex(GO:"NLRP3 inflammasome complex") increases p(HGNC:IL1B) + path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:FUS) - pmid:24561250 + pubmed:30837838 - complex(GO:"NLRP3 inflammasome complex") increases p(HGNC:IL1B) + path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:C9orf72) - pmid:28019679 + pubmed:30837838 - complex(GO:"NLRP3 inflammasome complex") increases act(p(HGNC:CASP1)) + path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:ATXN2) - pmid:28019679 + pubmed:30837838 - act(complex(GO:"NLRP3 inflammasome complex")) increases p(HGNC:CASP1) + path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:VCP) - - - pmid:27314526 + pubmed:30837838 - complex(GO:"NLRP3 inflammasome complex") increases p(HGNC:CASP1) + path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:PFN1) - pmid:28019679 + pubmed:30837838 - complex(GO:"NLRP3 inflammasome complex") increases a(CHEBI:"nitric oxide") + path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:UBQLN2) - pmid:28019679 + pubmed:30837838 - complex(GO:"NLRP3 inflammasome complex") increases sec(p(HGNC:TNF)) + path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:UBQLN4) - pmid:28019679 + pubmed:30837838 - act(complex(GO:"NLRP3 inflammasome complex")) decreases path(MESH:"Spatial Memory") + path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:NEK1) - pmid:28019679 + pubmed:30837838 - act(complex(GO:"NLRP3 inflammasome complex")) increases a(CHEBI:"amyloid-beta") + path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:MATR3) - + + + pubmed:30837838 + + path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:CHCHD10) + - pmid:24561250 + pubmed:30837838 - complex(GO:"NLRP3 inflammasome complex") association path(MESH:"Alzheimer Disease") + path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:SETX) - pmid:24561250 + pubmed:30837838 - complex(GO:"NLRP3 inflammasome complex") increases path(MESH:"Plaque, Amyloid") + path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:KIF5A) - pmid:28019679 + pubmed:30837838 - a(MESH:"Toll-Like Receptors") increases act(complex(GO:"NLRP3 inflammasome complex")) + path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation")) - + + + pubmed:30837838 + + path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation")) + - pmid:28019679 + pubmed:30837838 - composite(a(CHEBI:"amyloid-beta"), p(HGNC:CTSB)) increases act(complex(GO:"NLRP3 inflammasome complex")) + path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:TARDBP, frag("1_102")) - + + + pubmed:30837838 + + path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:TARDBP, frag("336_414")) + - pmid:28019679 + pubmed:30837838 - composite(a(CHEBI:"amyloid-beta"), p(HGNC:CD36)) increases act(complex(GO:"NLRP3 inflammasome complex")) + path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:TARDBP, var("p.Ala382Thr")) - pmid:28019679 + pubmed:30837838 - complex(GO:"NLRP1 inflammasome complex") increases act(p(HGNC:CASP1)) + path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:TARDBP, var("p.Met337Val")) - pmid:23702978 + pubmed:30837838 - complex(GO:"NLRP1 inflammasome complex") increases act(p(HGNC:CASP1)) + path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:TARDBP, var("p.Met337Val")) - - - pmid:28019679 + pubmed:30837838 - act(complex(GO:"NLRP1 inflammasome complex")) increases act(p(HGNC:CASP6)) + path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:TARDBP, var("p.Ala315Thr")) - pmid:28019679 + pubmed:30837838 - act(complex(GO:"NLRP1 inflammasome complex")) increases a(CHEBI:"amyloid-beta polypeptide 42") + path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:TARDBP, var("p.Gln331Lys")) - pmid:28019679 + pubmed:30837838 - complex(GO:"NLRP1 inflammasome complex") increases bp(GO:pyroptosis) + path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:TARDBP, var("p.Gln331Lys")) - pmid:28019679 + pubmed:30837838 - complex(GO:"NLRP1 inflammasome complex") increases bp(HBP:HBP00027) + path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:TARDBP, var("p.Asp169Gly")) - pmid:23702978 + pubmed:30837838 - complex(GO:"NLRP1 inflammasome complex") increases act(p(HGNC:CASP5)) + path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:TARDBP, var("p.Gly294Ala")) - - - pmid:24561250 + pubmed:30837838 - complex(GO:"NLRP1 inflammasome complex") increases p(HGNC:IL1B) + path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:TARDBP, var("p.Gly294Val")) - pmid:24561250 + pubmed:30837838 - act(complex(GO:"NLRP1 inflammasome complex")) increases p(HGNC:IL1B) + path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:TARDBP, var("p.Gln343Arg")) - pmid:24561250 + pubmed:30837838 - act(complex(GO:"NLRP1 inflammasome complex")) increases sec(p(HGNC:IL1B)) + path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:TARDBP, var("p.Ala90Val")) - pmid:24561250 + pubmed:30837838 - act(complex(GO:"NLRP1 inflammasome complex")) increases sec(p(HGNC:IL18)) + path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:TARDBP, var("p.Asn267Ser")) - - - + + + pubmed:30837838 + + path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:TARDBP, var("p.Gly348Cys")) + - pmid:23702978 + pubmed:30837838 - complex(GO:"inflammasome complex") increases act(p(HGNC:IL1B)) + path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:TARDBP, var("p.Ala328Thr")) - pmid:24561250 + pubmed:30837838 - complex(GO:"inflammasome complex") positiveCorrelation p(HGNC:IL1B) + path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:TARDBP, var("p.Ser393Leu")) - pmid:24561250 + pubmed:30837838 - complex(GO:"inflammasome complex") increases p(HGNC:IL1B) + path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:TARDBP, var("p.Gly295Ser")) - pmid:24561250 + pubmed:30837838 - complex(GO:"inflammasome complex") regulates p(HGNC:IL1B) + path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:TARDBP, frag("274_414"), pmod(go:0006468 ! "protein phosphorylation")) - pmid:27314526 + pubmed:30837838 - complex(GO:"inflammasome complex") increases act(p(HGNC:IL1B)) + path(MESH:"Amyotrophic Lateral Sclerosis") association path(MESH:Oxidation-Reduction) - pmid:23702978 + pubmed:30837838 - complex(GO:"inflammasome complex") increases act(p(HGNC:IL18)) + path(MESH:"Amyotrophic Lateral Sclerosis") association path(MESH:"Oxidative Stress") - pmid:24561250 + pubmed:30837838 - complex(GO:"inflammasome complex") positiveCorrelation p(HGNC:IL18) + path(MESH:"Amyotrophic Lateral Sclerosis") association bp(GO:"peptidyl-cysteine oxidation") - pmid:24561250 + pubmed:30837838 - complex(GO:"inflammasome complex") increases p(HGNC:IL18) + path(MESH:"Amyotrophic Lateral Sclerosis") increases p(HGNC:TARDBP, pmod(GO:"protein complex oligomerization")) - pmid:24561250 + pubmed:30837838 - act(complex(GO:"inflammasome complex")) increases p(HGNC:IL18) + path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:TARDBP, var("p.Ala321Gly")) - pmid:24561250 + pubmed:30837838 - complex(GO:"inflammasome complex") regulates p(HGNC:IL18) + path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:MAP1LC3A, loc(GO:"inclusion body")) - pmid:27314526 + pubmed:30837838 - complex(GO:"inflammasome complex") increases act(p(HGNC:IL18)) + path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:UBQLN2, var("?")) - + + + pubmed:30837838 + + path(MESH:"Amyotrophic Lateral Sclerosis") negativeCorrelation path(MESH:Endocytosis) + - pmid:23702978 + pubmed:30837838 - complex(GO:"inflammasome complex") increases act(p(HGNC:CASP1)) + path(MESH:"Amyotrophic Lateral Sclerosis") association a(CHEBI:"iron(3+)") - pmid:23702978 + pubmed:30837838 - complex(GO:"inflammasome complex") increases act(p(HGNC:CASP1)) + path(MESH:"Amyotrophic Lateral Sclerosis") association path(MESH:"Chromatin Assembly and Disassembly") - pmid:24561250 + pubmed:30837838 - act(complex(GO:"inflammasome complex")) increases act(p(HGNC:CASP1)) + path(MESH:"Amyotrophic Lateral Sclerosis") association p(HGNC:TARDBP, var("Met337Val")) - pmid:27314526 + pubmed:26813123 - act(complex(GO:"inflammasome complex")) increases act(p(HGNC:CASP1)) + path(MESH:"Supranuclear Palsy, Progressive") negativeCorrelation a(MESH:"Cholinergic Neurons") - pmid:27314526 + pubmed:29758300 - complex(GO:"inflammasome complex") increases act(p(HGNC:CASP1)) + path(MESH:"Supranuclear Palsy, Progressive") association p(HGNC:MAPT) - pmid:23702978 + pubmed:30126037 - act(complex(GO:"inflammasome complex")) increases bp(GO:pyroptosis) + path(MESH:"Supranuclear Palsy, Progressive") association p(HGNC:MAPT) - pmid:23702978 + pubmed:30126037 - complex(GO:"inflammasome complex") increases bp(GO:pyroptosis) + path(MESH:"Supranuclear Palsy, Progressive") increases p(CONSO:CONSO00045) - pmid:27314526 + pubmed:30126037 - complex(GO:"inflammasome complex") increases bp(GO:pyroptosis) + path(MESH:"Supranuclear Palsy, Progressive") increases a(GO:"neurofibrillary tangle") - + + + pubmed:11089576 + + path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation a(GO:"neurofibrillary tangle") + + + + pubmed:30126037 + + path(MESH:"Supranuclear Palsy, Progressive") increases bp(HP:Neurodegeneration) + + + + + pubmed:30126037 + + path(MESH:"Supranuclear Palsy, Progressive") increases path(MESH:Gliosis) + + + + + pubmed:30126037 + + path(MESH:"Supranuclear Palsy, Progressive") increases path(MESH:"Motor Disorders") + + + + + pubmed:30126037 + + path(MESH:"Supranuclear Palsy, Progressive") association path(MESH:"Parkinsonian Disorders") + + + + + pubmed:30126037 + + path(MESH:"Supranuclear Palsy, Progressive") association path(MESH:Tauopathies) + + + + + pubmed:29311797 + + path(MESH:"Supranuclear Palsy, Progressive") isA path(MESH:Tauopathies) + + + + + pubmed:26631930 + + path(MESH:"Supranuclear Palsy, Progressive") isA path(MESH:Tauopathies) + + - pmid:23702978 + pubmed:30126037 - complex(GO:"inflammasome complex") increases act(p(HGNC:SCAF11)) + path(MESH:"Supranuclear Palsy, Progressive") increases path(MESH:"Cognitive Dysfunction") + + + pubmed:30126037 + + path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HGNC:CDKN2A) + + - pmid:27314526 + pubmed:29191965 - complex(GO:"inflammasome complex") increases act(p(HGNC:IL33)) + path(MESH:"Supranuclear Palsy, Progressive") association p(HGNC:MAPT, var("p.Ala152Thr")) - pmid:27314526 + pubmed:26631930 - complex(GO:"inflammasome complex") association path(MESH:"Alzheimer Disease") + path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HGNC:MAPT, var("p.Ala152Thr")) - pmid:23702978 + pubmed:28420982 - p(HGNC:PYCARD) increases complex(p(HGNC:CASP1), p(HGNC:CASP1)) + path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation a(CONSO:"Tau oligomers") - pmid:24561250 + pubmed:26631930 - p(HGNC:PYCARD) association composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) + path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation a(CONSO:"Tau oligomers") - pmid:24561250 + pubmed:26751493 - p(HGNC:PYCARD) association composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) + path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(CONSO:"4R tau") - pmid:24561250 + pubmed:26631930 - p(HGNC:PYCARD) increases act(complex(GO:"IPAF inflammasome complex")) + path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(CONSO:"4R tau") - pmid:24561250 + pubmed:26631930 - p(HGNC:PYCARD) increases act(complex(GO:"IPAF inflammasome complex")) + path(MESH:"Supranuclear Palsy, Progressive") negativeCorrelation m(HGNC:MIR132) - pmid:24561250 + pubmed:26631930 - p(HGNC:PYCARD) increases act(complex(GO:"IPAF inflammasome complex")) + path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HGNC:SRSF2) - pmid:24561250 + pubmed:26631930 - p(HGNC:PYCARD) increases p(HGNC:IL18) + path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) - pmid:24561250 + pubmed:12578227 - p(HGNC:PYCARD) increases p(HGNC:IL1B) + path(MESH:"Supranuclear Palsy, Progressive") increases p(HGNC:TGM1) - pmid:24561250 + pubmed:12578227 - p(HGNC:PYCARD) positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:"Supranuclear Palsy, Progressive") increases r(HGNC:TGM1) - pmid:23702978 + pubmed:12578227 - path(MESH:"Immune System Diseases") increases path(MESH:Atherosclerosis) + path(MESH:"Supranuclear Palsy, Progressive") increases p(CONSO:"TGM2 Isoform 3 (349 aa)") - pmid:23702978 + pubmed:12578227 - path(MESH:"Immune System Diseases") increases path(MESH:"Diabetes Mellitus, Type 2") + path(MESH:"Supranuclear Palsy, Progressive") increases r(HGNC:TGM2) - pmid:23702978 + pubmed:11089576 - path(MESH:"Immune System Diseases") increases path(MESH:"Neurodegenerative Diseases") + path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation act(p(ECCODE:2.3.2.13)) + + + pubmed:22057784 + + path(MESH:"Supranuclear Palsy, Progressive") positiveCorrelation p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 197)) + + - pmid:23702978 + pubmed:17050703 - complex(p(HGNC:CASP1), p(HGNC:CASP1)) increases act(p(HGNC:CASP1)) + path(MESH:"Supranuclear Palsy, Progressive") association p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) - pmid:23702978 + pubmed:29281045 - bp(GO:"cell activation") increases p(HGNC:IL18) + path(MESH:"Supranuclear Palsy, Progressive") decreases p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) - pmid:24561250 + pubmed:29281045 - p(HGNC:NLRP1) increases p(HGNC:IL18) + path(MESH:"Supranuclear Palsy, Progressive") decreases p(HGNC:LCMT1) - pmid:24561250 + pubmed:29281045 - p(HGNC:NLRP1) increases p(HGNC:IL1B) + path(MESH:"Supranuclear Palsy, Progressive") increases p(HGNC:PPME1) + + + pubmed:30837838 + + path(MESH:"Supranuclear Palsy, Progressive") association p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation"), loc(GO:"inclusion body")) + + + + + pubmed:30837838 + + path(MESH:"Supranuclear Palsy, Progressive") association p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination"), loc(GO:"inclusion body")) + + - pmid:27314526 + pubmed:26813123 - p(HGNC:NLRP3) association a(CHEBI:"amyloid-beta") + path(MESH:"Olivopontocerebellar Atrophies") negativeCorrelation a(MESH:"Cholinergic Neurons") - pmid:27314526 + pubmed:26813123 - act(p(HGNC:NLRP3)) increases sec(p(HGNC:CASP1)) + act(a(GO:"cholinergic synapse")) association a(CONSO:"amyloid-beta oligomers") - pmid:23702978 + pubmed:26813123 - p(HGNC:NLRP6) increases bp(GO:"negative regulation of innate immune response") + complex(a(MESH:"Amyloid beta-Peptides"), p(HGNC:ACHE)) increases a(CONSO:"amyloid-beta fibrils") - pmid:23702978 + pubmed:26813123 - p(HGNC:NLRP12) increases bp(GO:"dendritic cell migration") + p(MGI:App, var("?")) decreases tloc(a(CHEBI:choline), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) - pmid:23702978 + pubmed:26813123 - p(HGNC:NLRP12) increases bp(GO:"negative regulation of NIK/NF-kappaB signaling") + p(MGI:App, var("?")) decreases p(FPLX:CHRM) - pmid:23702978 + pubmed:26813123 - act(p(HGNC:NLRC4)) increases complex(p(HGNC:CFL1), p(HGNC:SCAF11)) + p(MGI:App, var("?")) decreases p(FPLX:CHRN) + + + pubmed:22419736 + + p(MGI:App, var("?")) increases p(MGI:Ak1) + + - pmid:24561250 + pubmed:26813123 - p(HGNC:NLRC4) positiveCorrelation path(MESH:"Alzheimer Disease") + a(PUBCHEM:10013505) increases act(p(HGNC:CHRM1)) - pmid:23702978 + pubmed:26813123 - complex(GO:"IPAF inflammasome complex") increases act(p(HGNC:CASP1)) + a(PUBCHEM:10013505) increases bp(GO:cognition) - pmid:24561250 + pubmed:26813123 - complex(GO:"IPAF inflammasome complex") increases p(HGNC:IL1B) + a(PUBCHEM:10013505) decreases a(CHEBI:"amyloid-beta polypeptide 42") - pmid:24561250 + pubmed:26813123 - complex(GO:"IPAF inflammasome complex") increases sec(p(HGNC:IL1B)) + a(PUBCHEM:10013505) decreases p(HGNC:MAPT, var("?")) - pmid:24561250 + pubmed:26813123 - act(complex(GO:"IPAF inflammasome complex")) increases sec(p(HGNC:IL1B)) + a(PUBCHEM:10013505) increases a(MESH:"Amyloid Precursor Protein Secretases") - pmid:24561250 + pubmed:24653673 - complex(GO:"IPAF inflammasome complex") increases p(HGNC:IL1B) + p(HGNC:MAPT, var("?")) decreases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:MAPT)) - pmid:24561250 + pubmed:22299660 - complex(GO:"IPAF inflammasome complex") association path(MESH:"Alzheimer Disease") + p(HGNC:MAPT, var("?")) association path(MESH:"Frontotemporal Dementia") + + + pubmed:30116051 + + p(HGNC:MAPT, var("?")) decreases act(complex(GO:"proteasome complex")) + + - pmid:23702978 + pubmed:30116051 - composite(complex(GO:"NLRP1 inflammasome complex"), p(HGNC:PYCARD)) increases act(p(HGNC:CASP1)) + p(HGNC:MAPT, var("?")) decreases deg(p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) + + + pubmed:30116051 + + p(HGNC:MAPT, var("?")) decreases deg(a(CONSO:"Tau oligomers")) + + + + + pubmed:30116051 + + p(HGNC:MAPT, var("?")) decreases bp(GO:"chaperone-mediated autophagy") + + - pmid:23702978 + pubmed:29215007 - composite(complex(GO:"IPAF inflammasome complex"), p(HGNC:PYCARD)) increases act(p(HGNC:CASP1)) + p(HGNC:MAPT, var("?")) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:23702978 + pubmed:29980653 - act(p(HGNC:IFI16)) increases act(p(HGNC:TMEM173)) + p(HGNC:MAPT, var("?")) positiveCorrelation path(MESH:"Alzheimer Disease") - pmid:23702978 + pubmed:21734277 - act(p(HGNC:DDX58)) increases act(p(HGNC:MAVS)) + p(HGNC:MAPT, var("?")) increases p(CONSO:"phosphatase-activating domain") - pmid:23702978 + pubmed:29988016 - a(CHEBI:"RNA fragment") increases act(p(HGNC:DDX58)) + act(p(HGNC:MAPT, var("?"))) increases a(CONSO:"Tau aggregates") - pmid:27314526 + pubmed:29988016 - a(CHEBI:"RNA fragment") increases act(complex(GO:"NLRP3 inflammasome complex")) + act(p(HGNC:MAPT, var("?"))) increases a(CONSO:"Tau aggregates") - pmid:23702978 + pubmed:21882945 - act(p(HGNC:MAVS)) increases bp(GO:"response to type I interferon") + p(HGNC:MAPT, var("?")) increases a(CONSO:"Tau aggregates") - pmid:23702978 + pubmed:26631930 - a(CHEBI:"DNA polyanion") increases act(p(HGNC:IFI16)) + p(HGNC:MAPT, var("?")) increases a(CONSO:"Tau aggregates") - pmid:23702978 + pubmed:21882945 - act(p(HGNC:TMEM173)) increases bp(GO:"response to type I interferon") + p(HGNC:MAPT, var("?")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) - pmid:23702978 + pubmed:21882945 - a(CHEBI:"muramyl dipeptide") increases act(p(HGNC:NLRP1)) + p(HGNC:MAPT, var("?")) association bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") + + + pubmed:26631930 + + p(HGNC:MAPT, var("?")) increases tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) + + + + + pubmed:26631930 + + p(HGNC:MAPT, var("?")) decreases act(a(GO:synapse)) + + - pmid:23702978 + pubmed:29980653 - complex(a(CHEBI:"muramyl dipeptide"), p(HGNC:NLRP1)) increases act(complex(GO:"inflammasome complex")) + p(HGNC:MAPT, var("?")) positiveCorrelation path(MESH:Tauopathies) + + + pubmed:26813123 + + a(PUBCHEM:9867750) increases tloc(a(CHEBI:acetylcholine), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) + + + + + pubmed:26813123 + + a(PUBCHEM:9867750) increases act(p(HGNC:CHRM1)) + + - pmid:23702978 + pubmed:26813123 - complex(p(HGNC:NLRP1), p(HGNC:NOD2)) increases act(complex(GO:"inflammasome complex")) + a(PUBCHEM:9867750) increases act(a(MESH:"Receptors, Nicotinic")) + + + pubmed:26813123 + + a(PUBCHEM:9867750) increases bp(GO:cognition) + + + + + pubmed:29724491 + + path(MESH:"Mood Disorders") association p(HGNC:ADNP, var("?")) + + - pmid:23702978 + pubmed:30988501 - act(p(HGNC:NAIP)) increases complex(GO:"IPAF inflammasome complex") + path(MESH:"Mood Disorders") association bp(MESH:"Immunity, Cellular") - pmid:24561250 + pubmed:26813123 - p(HGNC:NAIP) increases act(complex(GO:"IPAF inflammasome complex")) + a(PUBCHEM:1476756) increases bp(GO:"excitatory postsynaptic potential") - pmid:23702978 + pubmed:26813123 - p(HGNC:SCAF11) increases bp(GO:pyroptosis) + a(PUBCHEM:1476756) increases bp(GO:memory) - pmid:23702978 + pubmed:26813123 - act(p(HGNC:SCAF11)) increases bp(GO:pyroptosis) + a(MESH:"Nerve Growth Factor") increases a(MESH:"Cholinergic Neurons") - pmid:23702978 + pubmed:26813123 - a(CHEBI:"LPS with O-antigen") increases bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") + a(MESH:"Nerve Growth Factor") increases a(MESH:"Cholinergic Neurons") - pmid:23702978 + pubmed:26813123 - bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") regulates sec(a(MESH:"Interferon Type I")) + a(MESH:"Nerve Growth Factor") increases bp(GO:memory) - pmid:23702978 + pubmed:11230871 - bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") increases p(HGNC:SCAF11) + a(MESH:"Nerve Growth Factor") increases complex(a(CHEBI:nicotine), p(FPLX:CHRN)) - pmid:23702978 + pubmed:31248781 - bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") increases act(p(HGNC:IFNAR1)) + composite(complex(CONSO:gamma-secretase), p(HGNC:APP), p(HGNC:BACE1)) increases p(HGNC:APP, frag("?")) + + - pmid:23702978 + pubmed:31248781 - bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") increases act(p(HGNC:CASP8)) + p(HGNC:APP, frag("?")) increases a(CHEBI:amyloid-beta) - pmid:23702978 + pubmed:23516100 - a(MESH:"Interferon Type I") decreases sec(p(HGNC:IL1B)) + p(HGNC:APP, frag("?")) increases complex(MESH:"Neurofibrillary Tangles") - pmid:23702978 + pubmed:23516100 - a(MESH:"Interferon Type I") decreases sec(p(HGNC:IL18)) + p(HGNC:APP, frag("?")) increases path(MESH:"Plaque, Amyloid") - pmid:23702978 + pubmed:31248781 - act(p(HGNC:IFNAR1)) increases act(p(HGNC:SCAF11)) + complex(GO:"neurotransmitter receptor complex") association bp(MESH:Neuroprotection) - pmid:23702978 + pubmed:31248781 - p(HGNC:IFNAR1) increases act(p(HGNC:SCAF11)) + act(p(MESH:Caspases)) negativeCorrelation bp(MESH:Neuroprotection) + + + pubmed:23516100 + + act(p(MESH:Caspases)) increases p(HGNC:MAPT, frag("?")) + + + + + pubmed:23516100 + + act(p(MESH:Caspases)) increases p(HGNC:MAPT, frag("?")) + + - pmid:23702978 + pubmed:23516100 - p(HGNC:PRTN3) increases act(p(HGNC:IL1B)) + act(p(MESH:Caspases)) increases p(HGNC:HTT, frag("?")) - pmid:23702978 + pubmed:30837838 - p(HGNC:CASP8) increases act(p(HGNC:IL1B)) + p(MESH:Caspases) increases p(HGNC:TARDBP, frag("?")) - pmid:23702978 + pubmed:31248781 - act(p(HGNC:CASP8)) increases act(p(HGNC:IL1B)) + composite(a(CHEBI:amyloid-beta), p(HGNC:GRM5), p(HGNC:PRNP)) decreases bp(GO:"synaptic signaling") - pmid:23702978 + pubmed:31248781 - act(p(HGNC:CASP8)) regulates act(p(HGNC:IL1B)) + composite(a(CHEBI:amyloid-beta), p(HGNC:GRM5), p(HGNC:PRNP)) decreases bp(GO:"neuronal signal transduction") - pmid:23702978 + pubmed:31248781 - act(p(HGNC:CASP8)) regulates act(p(HGNC:IL18)) + composite(a(CHEBI:amyloid-beta), p(HGNC:GRM5), p(HGNC:PRNP)) increases bp(GO:"neuron death") - pmid:23702978 + pubmed:31248781 - act(p(HGNC:CLEC7A)) increases act(p(HGNC:SYK)) + composite(a(CHEBI:amyloid-beta), p(MESH:"Receptors, Islet Amyloid Polypeptide")) decreases bp(GO:"synaptic signaling") + + + + + + + pubmed:31248781 + + composite(a(CHEBI:amyloid-beta), p(MESH:"Receptors, Islet Amyloid Polypeptide")) decreases bp(GO:"neuronal signal transduction") + + + pubmed:31248781 + + composite(a(CHEBI:amyloid-beta), p(MESH:"Receptors, Islet Amyloid Polypeptide")) increases bp(GO:"neuron death") + + - pmid:23702978 + pubmed:31248781 - complex(p(HGNC:CASP8), p(HGNC:MALT1)) increases complex(p(HGNC:CASP8), p(HGNC:MALT1), p(HGNC:PYCARD)) + p(MESH:"Receptors, Islet Amyloid Polypeptide") regulates a(MESH:"Autonomic Nervous System") @@ -164194,866 +165669,1012 @@

Statements

+ + + pubmed:31248781 + + composite(a(CHEBI:amyloid-beta), p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) decreases bp(GO:"synaptic signaling") + + - pmid:23702978 + pubmed:31248781 - complex(p(HGNC:CASP8), p(HGNC:MALT1), p(HGNC:PYCARD)) increases act(p(HGNC:IL1B)) + composite(a(CHEBI:amyloid-beta), p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) decreases bp(GO:"neuronal signal transduction") - pmid:23702978 + pubmed:31248781 - complex(GO:ripoptosome) increases act(p(HGNC:CASP8)) + composite(a(CHEBI:amyloid-beta), p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) increases bp(GO:"neuron death") + + + pubmed:31248781 + + composite(a(CHEBI:amyloid-beta), p(HGNCGENEFAMILY:"Glutamate ionotropic receptor AMPA type subunits")) decreases bp(GO:"synaptic signaling") + + + + + pubmed:31248781 + + composite(a(CHEBI:amyloid-beta), p(HGNCGENEFAMILY:"Glutamate ionotropic receptor AMPA type subunits")) decreases bp(GO:"neuronal signal transduction") + + + + + pubmed:31248781 + + composite(a(CHEBI:amyloid-beta), p(HGNCGENEFAMILY:"Glutamate ionotropic receptor AMPA type subunits")) increases bp(GO:"neuron death") + + - pmid:23702978 + pubmed:31248781 - complex(GO:ripoptosome) increases act(p(HGNC:RIPK3)) + composite(a(CHEBI:amyloid-beta), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) decreases bp(GO:"synaptic signaling") - pmid:23702978 + pubmed:31248781 - p(HGNC:XIAP) decreases complex(GO:ripoptosome) + composite(a(CHEBI:amyloid-beta), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) decreases bp(GO:"neuronal signal transduction") - pmid:23702978 + pubmed:31248781 - p(HGNC:BIRC3) decreases complex(GO:ripoptosome) + composite(a(CHEBI:amyloid-beta), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases bp(GO:"neuron death") - pmid:23702978 + pubmed:31248781 - act(p(HGNC:RIPK3)) increases act(p(HGNC:IL1B)) + p(HGNC:IAPP) regulates a(CHEBI:glucose) - pmid:23702978 + pubmed:31248781 - act(p(HGNC:RIPK3)) increases act(p(HGNC:CASP1)) + p(HGNC:IAPP) association path(DOID:"diabetes mellitus") - pmid:23702978 + pubmed:31248781 - act(p(HGNC:RIPK3)) increases act(p(HGNC:CASP8)) + p(HGNC:IAPP) regulates bp(GO:"negative regulation of type B pancreatic cell development") + + - pmid:23702978 + pubmed:30837838 - p(FPLX:TNFRSF) increases p(HGNC:NLRP3) + p(HGNC:IAPP) association p(HGNC:TARDBP, frag("247_250")) - pmid:23702978 + pubmed:30837838 - p(HGNC:BRCC3) decreases p(HGNC:NLRP3, pmod(Ub)) + p(HGNC:IAPP) association p(HGNC:TARDBP, frag("312_316")) - pmid:23702978 + pubmed:31248781 - p(FPLX:IFNB) increases p(HGNC:AIM2) + path(DOID:"diabetes mellitus") association p(HGNC:IAPP) - pmid:23702978 + pubmed:26979166 - g(HGNC:NLRP3, var("?")) positiveCorrelation path(MESH:"Cryopyrin-Associated Periodic Syndromes") + path(DOID:"diabetes mellitus") positiveCorrelation path(MESH:Depression) + + + pubmed:26979166 + + path(DOID:"diabetes mellitus") positiveCorrelation path(DOID:"bipolar disorder") + + - pmid:24561250 + pubmed:31248781 - g(HGNC:NLRP3) increases a(CHEBI:"amyloid-beta") + complex(p(HGNC:IAPP), p(MESH:"Receptors, Islet Amyloid Polypeptide")) increases bp(GO:"neuron apoptotic process") - pmid:24561250 + pubmed:31248781 - g(HGNC:NLRP3) decreases bp(GO:memory) + complex(p(CHEBI:amyloid-beta), p(MESH:"Receptors, Islet Amyloid Polypeptide")) increases bp(GO:"neuron apoptotic process") - pmid:24561250 + pubmed:31248781 - g(HGNC:NLRP3) decreases bp(GO:behavior) + bp(GO:"neurotrophin signaling pathway") association p(HGNC:CREBBP) - pmid:23702978 + pubmed:31248781 - path(MESH:"Cryopyrin-Associated Periodic Syndromes") positiveCorrelation g(HGNC:NLRP3, var("?")) + bp(GO:"neurotrophin signaling pathway") association bp(MESH:"Cell Survival") - pmid:23702978 + pubmed:31248781 - bp(GO:"CD4-positive, alpha-beta T cell activation") decreases act(complex(GO:"NLRP1 inflammasome complex")) + a(DRUGBANK:Edaravone) decreases path(HP:"Ischemic stroke") - pmid:23702978 + pubmed:31248781 - bp(GO:"CD4-positive, alpha-beta T cell activation") decreases act(complex(GO:"NLRP3 inflammasome complex")) + a(DRUGBANK:Edaravone) decreases act(a(CHEBI:amyloid-beta)) - pmid:23702978 + pubmed:31248781 - p(HGNC:NLRP3, pmod(NO)) decreases act(p(HGNC:NLRP3)) + a(DRUGBANK:Edaravone) decreases path(MESH:"Oxidative Stress") - pmid:23702978 + pubmed:31248781 - a(MESH:Interferons) increases p(HGNC:AIM2) + a(DRUGBANK:Edaravone) decreases path(CONSO:"APP processing") - pmid:23702978 + pubmed:31248781 - a(MESH:Interferons) decreases p(HGNC:IL1B) + a(DRUGBANK:Edaravone) decreases path(MESH:"Plaque, Amyloid") - pmid:23702978 + pubmed:31248781 - a(MESH:Interferons) decreases act(complex(GO:"NLRP3 inflammasome complex")) + a(DRUGBANK:Edaravone) decreases path(CONSO:neuroinflammation) - pmid:23702978 + pubmed:31248781 - m(HGNC:MIR223) decreases p(HGNC:NLRP3) + a(DRUGBANK:Edaravone) decreases deg(a(MESH:Neurites)) - pmid:23702978 + pubmed:31248781 - act(complex(GO:apoptosome)) increases act(p(HGNC:CASP9)) + a(DRUGBANK:Edaravone) decreases deg(a(MESH:Dendrites)) - pmid:23702978 + pubmed:31248781 - p(HGNC:MAP3K7) association a(CHEBI:"calcium(2+)") + a(DRUGBANK:Edaravone) increases bp(GO:"synaptic signaling") - pmid:23702978 + pubmed:31248781 - p(HGNC:TRPM2) increases act(p(HGNC:NLRP3)) + a(DRUGBANK:Edaravone) increases bp(GO:behavior) - pmid:23702978 + pubmed:31248781 - act(p(HGNC:TRPM2)) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + p(MESH:"Amyloid beta-Peptides", frag("1_?")) regulates act(p(MESH:"Amyloid beta-Peptides", loc(MESH:Neurons))) - pmid:23702978 + pubmed:31248781 - p(HGNC:CASP9, pmod(NO)) decreases act(p(HGNC:CASP9)) + p(MESH:"Amyloid beta-Peptides", frag("1_?")) decreases path(CONSO:"mitochondrial dysfunction") - pmid:23702978 + pubmed:31248781 - p(HGNC:CASP1, pmod(NO)) decreases act(p(HGNC:CASP1)) + p(MESH:"Amyloid beta-Peptides", frag("1_?")) decreases path(MESH:"Oxidative Stress") + + + pubmed:31248781 + + p(MESH:"Amyloid beta-Peptides", frag("1_?")) decreases bp(GO:"neuron apoptotic process") + + + + + pubmed:31248781 + + p(MESH:"Amyloid beta-Peptides", frag("1_?")) increases bp(MESH:Neuroprotection) + + - pmid:23702978 + pubmed:31248781 - complex(p(HGNC:CARD8), p(HGNC:CASP9)) decreases act(p(HGNC:CASP9)) + p(MESH:"Amyloid beta-Peptides", frag("1_?")) positiveCorrelation bp(GO:behavior) + + + pubmed:31248781 + + p(MESH:"Amyloid beta-Peptides", frag("1_?")) decreases path(MESH:"Cell Death") + + - pmid:23702978 + pubmed:31248781 - complex(p(HGNC:CASP1), p(MGI:Casp12)) decreases act(p(HGNC:CASP1)) + p(MESH:"Amyloid beta-Peptides", frag("1_?")) increases bp(GO:"synaptic signaling") + + + + + + - pmid:23702978 + pubmed:31248781 - p(HGNC:CARD18) decreases act(p(HGNC:CASP1)) + p(MESH:"Amyloid beta-Peptides") increases path(CONSO:"mitochondrial dysfunction") - pmid:23702978 + pubmed:31248781 - p(HGNC:CARD16) decreases act(p(HGNC:CASP1)) + p(MESH:"Amyloid beta-Peptides") increases path(MESH:"Oxidative Stress") - pmid:23702978 + pubmed:31248781 - p(HGNC:CARD17) decreases p(HGNC:IL1B) + p(MESH:"Amyloid beta-Peptides") decreases bp(GO:"neuron apoptotic process") + + - pmid:23702978 + pubmed:31248781 - p(HGNC:PYDC1) decreases complex(complex(GO:"inflammasome complex"), p(HGNC:PYCARD)) + composite(p(MESH:"Amyloid Precursor Protein Secretases"), p(MESH:"Amyloid beta-Peptides")) increases p(MESH:"Amyloid beta-Peptides", frag("1_15")) + + + pubmed:31248781 + + composite(p(MESH:"Amyloid Precursor Protein Secretases"), p(MESH:"Amyloid beta-Peptides")) increases p(MESH:"Amyloid beta-Peptides", frag("1_16")) + + - pmid:23702978 + pubmed:26195256 - p(HGNC:PYDC2) decreases complex(complex(GO:"inflammasome complex"), p(HGNC:PYCARD)) + act(p(MESH:"Amyloid Precursor Protein Secretases")) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:amyloid-beta), p(CONSO:"APP C-terminally truncated carboxyl-terminal fragments"))) - pmid:23702978 + pubmed:31248781 - p(MGI:Mefv) decreases sec(p(MGI:Il1b)) + p(MESH:"Amyloid beta-Peptides", frag("1_15")) decreases a(CONSO:"amyloid-beta oligomers") - + + + pubmed:31248781 + + p(MESH:"Amyloid beta-Peptides", frag("1_15")) regulates act(p(MESH:"Amyloid beta-Peptides", loc(MESH:Neurons))) + - pmid:23702978 + pubmed:31248781 - composite(p(FPLX:HSP90), p(HGNC:SUGT1)) increases act(p(HGNC:NLRP3)) + p(MESH:"Amyloid beta-Peptides", frag("1_16")) decreases a(CONSO:"amyloid-beta oligomers") - pmid:24561250 + pubmed:31248781 - path(MESH:Stroke) increases complex(GO:"inflammasome complex") + p(MESH:"Amyloid beta-Peptides", frag("1_16")) regulates act(p(MESH:"Amyloid beta-Peptides", loc(MESH:Neurons))) + + + pubmed:16273023 + + path(MESH:D000544) association path(MESH:D016874) + + + + + pubmed:16273023 + + path(MESH:D000544) association path(MESH:D058225) + + - pmid:24561250 + pubmed:16273023 - composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) association p(HGNC:NLRP2) + path(MESH:D000544) association bp(GO:"GO:0070997") - pmid:24561250 + pubmed:16273023 - composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) association p(HGNC:PYCARD) + path(MESH:D000544) decreases bp(MESH:D009435) - pmid:24561250 + pubmed:16273023 - composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) association p(HGNC:PYCARD) + path(MESH:D000544) decreases bp(GO:"GO:0007271") - pmid:24561250 + pubmed:16273023 - composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) increases p(HGNC:IL1B) + path(MESH:D000544) decreases bp(GO:"GO:0035249") - pmid:24561250 + pubmed:16273023 - composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) increases p(HGNC:IL1B) + path(MESH:D000544) decreases act(p(HGNC:CHAT), ma(go:0003824 ! "catalytic activity")) - pmid:24561250 + pubmed:16273023 - composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) association p(HGNC:CASP1) + path(MESH:D000544) decreases bp(GO:"GO:0015871") - pmid:24561250 + pubmed:16273023 - composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) increases p(HGNC:IL18) + path(MESH:D000544) decreases bp(GO:"GO:0008292") - pmid:24561250 + pubmed:16273023 - p(HGNC:NLRP2) association composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) + path(MESH:D000544) causesNoChange p(MESH:D011950) - pmid:24561250 + pubmed:16273023 - p(INTERPRO:"Leucine-rich repeat-containing adjacent domain") partOf a(MESH:"NLR Proteins") + path(MESH:D000544) decreases bp(GO:"GO:0051935") - pmid:24561250 + pubmed:16273023 - p(INTERPRO:"NACHT-associated domain") partOf a(MESH:"NLR Proteins") + path(MESH:D000544) decreases bp(GO:"GO:0014047") - pmid:24561250 + pubmed:16273023 - p(INTERPRO:"DAPIN domain") partOf p(INTERPRO:"NACHT-associated domain") + path(MESH:D000544) decreases bp(GO:"GO:0014047") - pmid:24561250 + pubmed:16273023 - p(INTERPRO:"CARD domain") partOf p(INTERPRO:"NACHT-associated domain") + path(MESH:D000544) decreases bp(MESH:D017774) - pmid:24561250 + pubmed:16273023 - p(INTERPRO:"BIR repeat") partOf p(INTERPRO:"NACHT-associated domain") + path(MESH:D000544) decreases bp(MESH:D017774) - pmid:24561250 + pubmed:16273023 - a(MESH:"Pathogen-Associated Molecular Pattern Molecules") increases complex(GO:"inflammasome complex") + path(MESH:D000544) decreases complex(a(CHEBI:"magnesium(2+)"), p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) - pmid:24561250 + pubmed:16273023 - a(MESH:"Pathogen-Associated Molecular Pattern Molecules") increases act(complex(GO:"inflammasome complex")) + path(MESH:D016874) association path(MESH:D000544) - pmid:24561250 + pubmed:16273023 - a(MESH:Alarmins) increases complex(GO:"inflammasome complex") + path(MESH:D058225) association path(MESH:D000544) - pmid:24561250 + pubmed:16273023 - a(MESH:Alarmins) increases act(complex(GO:"inflammasome complex")) + bp(GO:"GO:0070997") association path(MESH:D000544) - + + + pubmed:16273023 + + bp(GO:"GO:0070997") association act(p(MESH:D017470)) + - pmid:24561250 + pubmed:16273023 - complex(a(MESH:"NLR Proteins"), p(INTERPRO:"NACHT-associated domain")) increases complex(GO:"inflammasome complex") + bp(GO:"GO:0007271") association path(MESH:D003071) - + + + pubmed:16273023 + + bp(GO:"GO:0007271") association path(MESH:D003071) + + + + pubmed:16273023 + + bp(GO:"GO:0007271") association a(MESH:D002800) + + - pmid:24561250 + pubmed:16273023 - complex(p(HGNC:CASP1), p(HGNC:NLRP1), p(HGNC:PYCARD)) increases act(complex(GO:"NLRP1 inflammasome complex")) + bp(GO:"GO:0035249") association path(MESH:D003071) - + + + pubmed:16273023 + + bp(GO:"GO:0035249") association path(MESH:D003071) + + + + pubmed:16273023 + + bp(GO:"GO:0035249") increases bp(GO:"GO:0051935") + + - pmid:24561250 + pubmed:16273023 - complex(p(HGNC:CASP1), p(HGNC:NLRP3), p(HGNC:PYCARD)) increases act(complex(GO:"NLRP3 inflammasome complex")) + bp(GO:"GO:0035249") association a(CHEBI:"NMDA receptor antagonist") - pmid:24561250 + pubmed:16273023 - a(MESH:Bacteria) increases act(complex(GO:"inflammasome complex")) + path(MESH:D003071) association bp(GO:"GO:0035249") - pmid:24561250 + pubmed:16273023 - a(MESH:Fungi) increases act(complex(GO:"inflammasome complex")) + path(MESH:D003071) association bp(GO:"GO:0035249") - pmid:24561250 + pubmed:16273023 - a(CHEBI:"potassium aluminium sulfate") increases act(complex(GO:"inflammasome complex")) + path(MESH:D003071) association bp(GO:"GO:0007271") - pmid:24561250 + pubmed:16273023 - deg(a(MESH:"DNA, Mitochondrial")) increases act(complex(GO:"inflammasome complex")) + path(MESH:D003071) association bp(GO:"GO:0007271") - pmid:24561250 + pubmed:16273023 - path(MESH:"Spinal Cord Injuries") increases act(complex(GO:"NLRP1 inflammasome complex")) + bp(GO:"GO:0008292") negativeCorrelation path(MESH:D003704) - pmid:24561250 + pubmed:16273023 - path(MESH:"Spinal Cord Injuries") increases act(complex(GO:"NLRP1 inflammasome complex")) + path(MESH:D003704) negativeCorrelation bp(GO:"GO:0008292") + + + + - pmid:24561250 + pubmed:16273023 - path(MESH:"Spinal Cord Injuries") increases sec(p(HGNC:IL18)) + path(MESH:D013850) association a(MESH:D006624) - pmid:24561250 + pubmed:16273023 - path(MESH:"Spinal Cord Injuries") increases sec(p(HGNC:IL1B)) + path(MESH:D013850) association a(MESH:D019579) - pmid:24561250 + pubmed:16273023 - path(MESH:"Spinal Cord Injuries") increases a(CHEBI:ATP) + path(MESH:D013850) association a(CHEBI:"glutamate(1-)") - pmid:24561250 + pubmed:16273023 - p(HGNC:P2RX7) increases act(complex(GO:"NLRP1 inflammasome complex")) + a(MESH:D006624) association path(MESH:D013850) - pmid:24561250 + pubmed:16273023 - p(HGNC:P2RX7) increases act(complex(GO:"NLRP1 inflammasome complex")) + a(MESH:D006624) association path(MESH:D008568) - pmid:27314526 + pubmed:16273023 - act(p(HGNC:P2RX7)) increases bp(GO:"inflammatory response") + a(MESH:D019579) association path(MESH:D013850) - pmid:27314526 + pubmed:16273023 - act(p(HGNC:P2RX7)) increases bp(GO:"apoptotic process") + a(MESH:D019579) association path(MESH:D008568) - pmid:27314526 + pubmed:16273023 - act(p(HGNC:P2RX7)) increases bp(GO:"cell proliferation") + path(MESH:D008568) association a(MESH:D006624) - pmid:27314526 + pubmed:16273023 - p(HGNC:P2RX7) increases act(complex(GO:"NLRP3 inflammasome complex")) + path(MESH:D008568) association a(MESH:D019579) - pmid:27314526 + pubmed:16273023 - p(HGNC:P2RX7) positiveCorrelation path(MESH:"Alzheimer Disease") + path(MESH:D008568) association a(CHEBI:"glutamate(1-)") - pmid:24561250 + pubmed:16273023 - p(MGI:P2rx4) increases act(complex(GO:"NLRP1 inflammasome complex")) + path(MESH:D008568) association bp(MESH:D017774) - pmid:24561250 + pubmed:16273023 - p(MGI:P2rx4) increases p(HGNC:IL1B) + act(p(HGNC:GLS), ma(go:0003824 ! "catalytic activity")) directlyIncreases a(CHEBI:"glutamate(1-)") - pmid:24561250 + pubmed:16273023 - p(MGI:P2rx4) increases p(HGNC:IL1B) + bp(GO:"GO:0014047") increases bp(GO:"GO:0035249") - pmid:24561250 + pubmed:16273023 - p(MGI:P2rx4) increases act(complex(GO:"inflammasome complex")) + bp(GO:"GO:0014047") increases bp(MESH:D017774) - pmid:24561250 + pubmed:16273023 - p(MGI:P2rx7) increases act(complex(GO:"NLRP1 inflammasome complex")) + bp(GO:"GO:0051935") increases a(CHEBI:glutamine) + + + pubmed:16273023 + + a(CHEBI:glutamine) increases bp(GO:"GO:0006868") + + + + + pubmed:16273023 + + act(p(MESH:D017470)) association bp(GO:"GO:0070997") + + + + + pubmed:16273023 + + bp(MESH:D017774) association path(MESH:D008568) + + - pmid:24561250 + pubmed:16273023 - composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2), p(HGNC:P2RX7), p(HGNC:PANX1)) increases p(HGNC:IL1B) + bp(MESH:D017774) association path(MESH:D007858) - pmid:24561250 + pubmed:16273023 - p(HGNC:PANX1) increases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) + path(MESH:D007858) association bp(MESH:D017774) - pmid:24561250 + pubmed:16273023 - p(HGNC:PANX1) increases p(HGNC:IL1B) + a(MESH:D017966) association composite(p(MESH:D011950), p(MESH:D017470)) - pmid:24561250 + pubmed:16273023 - p(HGNC:PANX1) increases p(HGNC:IL18) + composite(p(MESH:D011950), p(MESH:D017470)) association a(MESH:D017966) - pmid:24561250 + pubmed:16273023 - a(CHEBI:hexadecanoate) increases complex(GO:"IPAF inflammasome complex") + a(MESH:D002800) increases bp(GO:"GO:0014047") - pmid:24561250 + pubmed:16273023 - a(CHEBI:hexadecanoate) increases act(complex(GO:"IPAF inflammasome complex")) + a(MESH:D002800) increases bp(GO:"GO:0014047") - pmid:24561250 + pubmed:16273023 - p(MGI:Nlrp3) increases p(MGI:Il1b) + a(MESH:D002800) increases a(CHEBI:acetylcholine) - pmid:24561250 + pubmed:16273023 - p(MGI:Nlrp3) increases bp(GO:"amyloid-beta formation") + a(MESH:D002800) association bp(GO:"GO:0007271") - pmid:24561250 + pubmed:16273023 - p(MGI:Nlrp3) increases a(MESH:Neuropathology) + complex(a(CHEBI:acetylcholine), p(MESH:D011950)) increases a(CHEBI:acetylcholine) - pmid:24561250 + pubmed:16273023 - p(MGI:Nlrp3) decreases bp(GO:cognition) + a(CHEBI:"magnesium(2+)") decreases complex(a(CHEBI:"calcium(2+)"), p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) @@ -165064,9 +166685,9 @@

Statements

- pmid:24561250 + pubmed:24590577 - composite(a(CHEBI:hexadecanoate), p(HGNC:PYCARD)) increases p(HGNC:IL1B) + complex(a(CHEBI:acetylcholine), p(FPLX:"G_protein"), p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")) increases bp(GO:"synaptic transmission, cholinergic") @@ -165075,17220 +166696,97535 @@

Statements

+ + - pmid:24561250 + pubmed:24590577 - composite(a(CHEBI:hexadecanoate), p(HGNC:NLRC4)) increases p(HGNC:IL1B) + complex(p(HGNC:CHRM1), p(HGNC:GNA11)) increases act(p(FPLX:PLC)) - pmid:24561250 + pubmed:24590577 - a(CHEBI:"saturated fatty acid") increases p(HGNC:IL1B) + complex(p(HGNC:CHRM1), p(HGNC:GNA11)) increases bp(GO:"calcium ion transport") + + + + + + - pmid:24561250 + pubmed:24590577 - a(CHEBI:probenecid) decreases p(HGNC:PANX1) + complex(p(HGNC:CHRM3), p(HGNC:GNA11)) increases act(p(FPLX:PLC)) - pmid:24561250 + pubmed:24590577 - a(CHEBI:probenecid) decreases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) + complex(p(HGNC:CHRM3), p(HGNC:GNA11)) increases bp(GO:"calcium ion transport") - pmid:24561250 + pubmed:24590577 - a(CHEBI:probenecid) decreases p(HGNC:IL1B) + complex(p(HGNC:CHRM5), p(HGNC:GNA11)) increases act(p(FPLX:PLC)) - pmid:24561250 + pubmed:24590577 - a(CHEBI:probenecid) decreases p(HGNC:IL18) + complex(p(HGNC:CHRM5), p(HGNC:GNA11)) increases bp(GO:"calcium ion transport") - pmid:24561250 + pubmed:24590577 - a(CHEBI:probenecid) decreases act(complex(GO:"NLRP1 inflammasome complex")) + complex(p(HGNC:CHRM2), p(HGNC:GNAO1)) decreases p(HGNCGENEFAMILY:"Adenylate cyclases") - pmid:24561250 + pubmed:24590577 - a(CHEBI:probenecid) increases bp(GO:learning) + complex(p(HGNC:CHRM2), p(HGNC:GNAO1)) decreases a(CHEBI:"3',5'-cyclic AMP") + + + + - pmid:24561250 + pubmed:24590577 - a(PUBCHEM:6324599) decreases act(p(HGNC:P2RX7)) + complex(p(HGNC:CHRM4), p(HGNC:GNAO1)) decreases p(HGNCGENEFAMILY:"Adenylate cyclases") - pmid:24561250 + pubmed:24590577 - a(PUBCHEM:6324599) decreases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) + complex(p(HGNC:CHRM4), p(HGNC:GNAO1)) decreases a(CHEBI:"3',5'-cyclic AMP") - pmid:24561250 + pubmed:24590577 - p(MGI:Casp1) increases bp(GO:"amyloid-beta formation") + path(MESH:Nociception) association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") - pmid:24561250 + pubmed:24590577 - p(MGI:Casp1) increases a(MESH:Neuropathology) + a(MESH:Kidney) association p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") - pmid:24561250 + pubmed:29626319 - p(MGI:Casp1) decreases bp(GO:cognition) + a(MESH:Kidney) increases deg(a(CHEBI:amyloid-beta)) - pmid:27314526 + pubmed:29626319 - bp(GO:"cytokine secretion") increases bp(GO:"inflammatory response") + a(MESH:Kidney) decreases a(CHEBI:amyloid-beta) - pmid:27314526 + pubmed:29626319 - act(p(HGNC:PRSS3)) increases p(HGNC:IL18) + a(MESH:Kidney) decreases a(CHEBI:amyloid-beta) - pmid:27314526 + pubmed:29626319 - act(p(FPLX:ELA)) increases p(HGNC:IL18) + a(MESH:Kidney) decreases a(CHEBI:"amyloid-beta polypeptide 40") - pmid:27314526 + pubmed:29626319 - act(p(HGNC:CTSG)) increases p(HGNC:IL18) + a(MESH:Kidney) causesNoChange a(CHEBI:"amyloid-beta polypeptide 42") + + + pubmed:24590577 + + a(MESH:Thalamus) association p(HGNC:CHRM1) + + + + + pubmed:24762290 + + a(MESH:Thalamus) association complex(CONSO:"alpha-4 beta-2 nAChR") + + - pmid:27314526 + pubmed:24762290 - composite(complex(GO:"NLRP3 inflammasome complex"), p(HGNC:CASP1), p(HGNC:PYCARD)) increases act(p(HGNC:CASP1)) + a(MESH:Thalamus) association complex(CONSO:"alpha-4 beta-2 nAChR") + + + pubmed:24590577 + + p(MGI:Chrm2) decreases path(MESH:"Nociceptive Pain") + + - pmid:27314526 + pubmed:24590577 - path(MESH:Periodontitis) decreases bp(GO:cognition) + a(MESH:Hypothalamus) association p(HGNC:CHRM3) - - - -

Curation Quality

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Namespaces

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-

- Namespace References - 18 -

-

- This section lists all of the namespaces that are defined in the original BEL document. -

- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
KeywordURL
CHEBIhttps://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns
DOIDhttps://raw.githubusercontent.com/pharmacome/terminology/c0c576e3d3ab9b25a3982251a4ee2fd7c49e1679/external/doid-names.belns
DRUGBANKhttps://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/drugbank-names.belns
ECCODEhttps://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/ec-code.belns
FBhttps://raw.githubusercontent.com/pharmacome/terminology/c328ad964c08967a0417a887510b97b965a62fa5/external/fb-names.belns
FPLXhttps://raw.githubusercontent.com/sorgerlab/famplex/e8ae9926ff95266032cb74f77973c84939bffbeb/export/famplex.belns
GOhttps://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/go-names.belns
HBPhttps://raw.githubusercontent.com/pharmacome/terminology/3074b85b858455d8eeb76cfcdef685ced19bbe11/export/hbp-names.belns
HGNChttps://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns
HGNCGENEFAMILYhttps://raw.githubusercontent.com/pharmacome/terminology/efc856fb009a39e4d284269a6801f79ed3d3cf56/external/hgnc.genefamily-names.belns
HPhttps://arty.scai.fraunhofer.de/artifactory/bel/namespace/hp/hp-20171108.belns
INTERPROhttps://arty.scai.fraunhofer.de/artifactory/bel/namespace/interpro/interpro-20170731.belns
MESHhttps://raw.githubusercontent.com/pharmacome/terminology/1b20f0637c395f8aa89c2e2e342d7b704062c242/external/mesh-names.belns
MGIhttps://arty.scai.fraunhofer.de/artifactory/bel/namespace/mgi-mouse-genes/mgi-mouse-genes-20170725.belns
MIRBASEhttps://raw.githubusercontent.com/pharmacome/terminology/c328ad964c08967a0417a887510b97b965a62fa5/external/mirbase-names.belns
NCBIGENEhttps://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/entrez.belns
PFAMhttps://raw.githubusercontent.com/pharmacome/terminology/8ccfed235e418e4c8aa576f9a5ef0f838e794c7f/external/pfam-names.belns
RGDhttps://arty.scai.fraunhofer.de/artifactory/bel/namespace/rgd-rat-genes/rgd-rat-genes-20170725.belns
- - -

- Unused Namespaces - 1 -

-

- The source BEL document contained references to the following namespaces, but they were never - used. It is suggested to delete their definitions from the BEL document to improve readability - and parsing speed. -

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  • - FB -
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- Namespaces with Incorrect Names - 3 -

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    • - -
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    • - -
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Annotations

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- Annotation References - 12 -

-

- This section lists all of the annotations that are defined in the original BEL document. -

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KeywordURL
Anatomyhttps://arty.scai.fraunhofer.de/artifactory/bel/annotation/anatomy/anatomy-20170511.belanno
Cellhttps://arty.scai.fraunhofer.de/artifactory/bel/annotation/cell/cell-20170511.belanno
CellLinehttps://arty.scai.fraunhofer.de/artifactory/bel/annotation/cell-line/cell-line-20170511.belanno
CellStructurehttps://arty.scai.fraunhofer.de/artifactory/bel/annotation/cell-structure/cell-structure-20170511.belanno
Confidencehttps://arty.scai.fraunhofer.de/artifactory/bel/annotation/confidence/confidence-1.0.0.belanno
Diseasehttps://arty.scai.fraunhofer.de/artifactory/bel/annotation/disease/disease-20170511.belanno
Genderhttps://arty.scai.fraunhofer.de/artifactory/bel/annotation/gender/gender-1.0.0.belanno
MeSHAnatomyhttps://arty.scai.fraunhofer.de/artifactory/bel/annotation/mesh-anatomy/mesh-anatomy-20170511.belanno
MeSHDiseasehttps://arty.scai.fraunhofer.de/artifactory/bel/annotation/mesh-diseases/mesh-diseases-20170511.belanno
Specieshttps://arty.scai.fraunhofer.de/artifactory/bel/annotation/species-taxonomy-id/species-taxonomy-id-20170511.belanno
Subgraphhttps://arty.scai.fraunhofer.de/artifactory/bel/annotation/neurommsig/neurommsig-1.0.3.belanno
TextLocationhttps://arty.scai.fraunhofer.de/artifactory/bel/annotation/text-location/text-location-1.0.1.belanno
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- Locally Defined Annotations - 34 -

-

- The source BEL document contained annotations defined as a list. Click each link to export - the list definition as a BELANNO file that can hosted externally to promote - re-usability and interoperability. After, you can replace the list definition in the source - BEL with a SET ANNOTATION X AS URL "Y" definition. -

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- Unused Locally Defined Annotations - 9 -

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- The source BEL document contained the following list annotations, but no references to the - following values. It is suggested to prune these values from the list definitions. -

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- Note: this may be due to errors occurring in all statements with these - annotations. -

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AnnotationValues
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Km_ATP -
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Warnings

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Warning Statistics

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- Most Frequent 10 Errors -

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ErrorFrequency
"pro-nerve growth factor, human" is not in the MESH namespace7
"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one" is not in the MESH namespace6
"latrepirdine" is not in the MESH namespace5
"Microtubule associated protein, tubulin-binding repeat" is not in the INTERPRO namespace5
"gambogic amide" is not in the MESH namespace3
"Synaptotagmins" is not in the HGNCGENEFAMILY namespace3
"Mitogen-activated protein kinases" is not in the HGNCGENEFAMILY namespace2
"Protein phosphatase catalytic subunits" is not in the HGNCGENEFAMILY namespace2
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All Errors - 35 -

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PathLineBELMessage
/Users/cthoyt/dev/hbp/knowledge/hbp_knowledge/receptors/mufson2008.bel365path(MESH:D060825) -> a(MESH:"pro-nerve growth factor, human")"pro-nerve growth factor, human" is not in the MESH namespace
/Users/cthoyt/dev/hbp/knowledge/hbp_knowledge/receptors/mufson2008.bel366path(MESH:D000544) -> a(MESH:"pro-nerve growth factor, human")"pro-nerve growth factor, human" is not in the MESH namespace
/Users/cthoyt/dev/hbp/knowledge/hbp_knowledge/receptors/mufson2008.bel368complex(a(MESH:"pro-nerve growth factor, human"), p(HGNC:NTRK1)) -> bp(GO:"GO:0031175")"pro-nerve growth factor, human" is not in the MESH namespace
/Users/cthoyt/dev/hbp/knowledge/hbp_knowledge/receptors/mufson2008.bel385a(MESH:"pro-nerve growth factor, human") pos path(MESH:D003072)"pro-nerve growth factor, human" is not in the MESH namespace
/Users/cthoyt/dev/hbp/knowledge/hbp_knowledge/receptors/mufson2008.bel398a(MESH:"pro-nerve growth factor, human") biomarkerFor path(MESH:D000544)"pro-nerve growth factor, human" is not in the MESH namespace
/Users/cthoyt/dev/hbp/knowledge/hbp_knowledge/receptors/mufson2008.bel414complex(a(MESH:"pro-nerve growth factor, human"), p(HGNC:NGFR)) -> bp(GO:"GO:0006915")"pro-nerve growth factor, human" is not in the MESH namespace
/Users/cthoyt/dev/hbp/knowledge/hbp_knowledge/receptors/mufson2008.bel450composite(complex(p(HGNC:NGFR), p(HGNC:SORT1)), a(MESH:"pro-nerve growth factor, human")) -> bp(GO:"GO:0006915")"pro-nerve growth factor, human" is not in the MESH namespace
/Users/cthoyt/dev/hbp/knowledge/hbp_knowledge/receptors/mufson2008.bel523p(HGNCGENEFAMILY:"Mitogen-activated protein kinases", pmod(Ph)) -> act(p(HGNCGENEFAMILY:"Mitogen-activated protein kinases"))"Mitogen-activated protein kinases" is not in the HGNCGENEFAMILY namespace
/Users/cthoyt/dev/hbp/knowledge/hbp_knowledge/receptors/mufson2008.bel544act(p(HGNCGENEFAMILY:"Mitogen-activated protein kinases")) -- bp(GO:"GO:0031175")"Mitogen-activated protein kinases" is not in the HGNCGENEFAMILY namespace
/Users/cthoyt/dev/hbp/knowledge/hbp_knowledge/receptors/mufson2008.bel603complex(a(MESH:"gambogic amide"), p(HGNC:NTRK1)) => p(HGNC:NTRK1, pmod(Ph))"gambogic amide" is not in the MESH namespace
/Users/cthoyt/dev/hbp/knowledge/hbp_knowledge/receptors/mufson2008.bel609a(MESH:"gambogic amide") -| bp(HBP:Excitotoxicity)"gambogic amide" is not in the MESH namespace
/Users/cthoyt/dev/hbp/knowledge/hbp_knowledge/receptors/mufson2008.bel610a(MESH:"gambogic amide") -> bp(GO:"GO:0031175")"gambogic amide" is not in the MESH namespace
/Users/cthoyt/dev/hbp/knowledge/hbp_knowledge/receptors/mufson2008.bel624p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") hasMembers list(p(HGNC:CHRNA1) , p(HGNC:CHRNA2), p(HGNC:CHRNA3), p(HGNC:CHRNA4), p(HGNC:CHRNA5), p(HGNC:CHRNA6), p(HGNC:CHRNA7), p(HGNC:CHRNA9), p(HGNC:CHRNA10), p(HGNC:CHRNB1), p(HGNC:CHRNB2), p(HGNC:CHRNB3), p(HGNC:CHRNB4), p(HGNC:CHRND), p(HGNC:CHRNG))"Cholinergic receptors nicotinic subunits" is not in the HGNCGENEFAMILY namespace
/Users/cthoyt/dev/hbp/knowledge/hbp_knowledge/receptors/mufson2008.bel629p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic") hasMembers list(p(HGNC:CHRM1), p(HGNC:CHRM2), p(HGNC:CHRM3), p(HGNC:CHRM4), p(HGNC:CHRM5))"Cholinergic receptors muscarinic" is not in the HGNCGENEFAMILY namespace
/Users/cthoyt/dev/hbp/knowledge/hbp_knowledge/receptors/mufson2008.bel732a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") -| path(MESH:D060825)"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one" is not in the MESH namespace
/Users/cthoyt/dev/hbp/knowledge/hbp_knowledge/receptors/mufson2008.bel733a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") -| path(MESH:D024801)"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one" is not in the MESH namespace
/Users/cthoyt/dev/hbp/knowledge/hbp_knowledge/receptors/mufson2008.bel734a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") -| a(CHEBI:"amyloid-beta polypeptide 42")"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one" is not in the MESH namespace
/Users/cthoyt/dev/hbp/knowledge/hbp_knowledge/receptors/mufson2008.bel735a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") -> act(p(MGI:Chrm1))"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one" is not in the MESH namespace
/Users/cthoyt/dev/hbp/knowledge/hbp_knowledge/receptors/mufson2008.bel737a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") -| p(MGI:Bace1)"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one" is not in the MESH namespace
/Users/cthoyt/dev/hbp/knowledge/hbp_knowledge/receptors/mufson2008.bel738a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") -| act(p(MGI:Gsk3b))"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one" is not in the MESH namespace
/Users/cthoyt/dev/hbp/knowledge/hbp_knowledge/receptors/mufson2008.bel758path(MESH:D000544) -| r(HGNCGENEFAMILY:"Synaptotagmins")"Synaptotagmins" is not in the HGNCGENEFAMILY namespace
/Users/cthoyt/dev/hbp/knowledge/hbp_knowledge/receptors/mufson2008.bel762p(HGNCGENEFAMILY:"Synaptotagmins") -- bp(GO:"GO:0031629")"Synaptotagmins" is not in the HGNCGENEFAMILY namespace
/Users/cthoyt/dev/hbp/knowledge/hbp_knowledge/receptors/mufson2008.bel764p(HGNCGENEFAMILY:"Synaptotagmins") -- bp(GO:"GO:0007269")"Synaptotagmins" is not in the HGNCGENEFAMILY namespace
/Users/cthoyt/dev/hbp/knowledge/hbp_knowledge/receptors/mufson2008.bel782p(HGNCGENEFAMILY:"Protein phosphatase catalytic subunits") -> p(HGNC:MAPT, pmod(Ph))"Protein phosphatase catalytic subunits" is not in the HGNCGENEFAMILY namespace
/Users/cthoyt/dev/hbp/knowledge/hbp_knowledge/receptors/mufson2008.bel783act(p(HGNCGENEFAMILY:"Protein phosphatase catalytic subunits")) -| bp(HBP:hyperphosphorylation)"Protein phosphatase catalytic subunits" is not in the HGNCGENEFAMILY namespace
/Users/cthoyt/dev/hbp/knowledge/hbp_knowledge/receptors/mufson2008.bel1007a(MESH:"latrepirdine") -| act(p(HGNC:BCHE))"latrepirdine" is not in the MESH namespace
/Users/cthoyt/dev/hbp/knowledge/hbp_knowledge/receptors/mufson2008.bel1008a(MESH:"latrepirdine") -| act(p(HGNC:ACHE))"latrepirdine" is not in the MESH namespace
/Users/cthoyt/dev/hbp/knowledge/hbp_knowledge/receptors/mufson2008.bel1010a(MESH:"latrepirdine") -| bp(GO:"GO:0098989")"latrepirdine" is not in the MESH namespace
/Users/cthoyt/dev/hbp/knowledge/hbp_knowledge/receptors/mufson2008.bel1012a(MESH:"latrepirdine") -| bp(GO:"GO:0046902")"latrepirdine" is not in the MESH namespace
/Users/cthoyt/dev/hbp/knowledge/hbp_knowledge/receptors/mufson2008.bel1013a(MESH:"latrepirdine") -> bp(MESH:D000066829)"latrepirdine" is not in the MESH namespace
/Users/cthoyt/dev/hbp/knowledge/hbp_knowledge/tau/nestor/tau_biochemistry.bel106p(HBP:"tubulin-binding repeat 1") isA p(INTERPRO:"Microtubule associated protein, tubulin-binding repeat")"Microtubule associated protein, tubulin-binding repeat" is not in the INTERPRO namespace
/Users/cthoyt/dev/hbp/knowledge/hbp_knowledge/tau/nestor/tau_biochemistry.bel107p(HBP:"tubulin-binding repeat 2") isA p(INTERPRO:"Microtubule associated protein, tubulin-binding repeat")"Microtubule associated protein, tubulin-binding repeat" is not in the INTERPRO namespace
/Users/cthoyt/dev/hbp/knowledge/hbp_knowledge/tau/nestor/tau_biochemistry.bel108p(HBP:"tubulin-binding repeat 3") isA p(INTERPRO:"Microtubule associated protein, tubulin-binding repeat")"Microtubule associated protein, tubulin-binding repeat" is not in the INTERPRO namespace
/Users/cthoyt/dev/hbp/knowledge/hbp_knowledge/tau/nestor/tau_biochemistry.bel109p(HBP:"tubulin-binding repeat 4") isA p(INTERPRO:"Microtubule associated protein, tubulin-binding repeat")"Microtubule associated protein, tubulin-binding repeat" is not in the INTERPRO namespace
/Users/cthoyt/dev/hbp/knowledge/hbp_knowledge/tau/nestor/tau_biochemistry.bel129p(INTERPRO:"Microtubule associated protein, tubulin-binding repeat", pmod(Ph)) -| complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins))"Microtubule associated protein, tubulin-binding repeat" is not in the INTERPRO namespace
- -
- -

Biogrammar

-
+ + + + pubmed:24590577 + + p(MGI:Chrm3) regulates bp(GO:"response to food") + + -

- Regulatory Pairs - 30 -

-

- These pairs of nodes represent motifs like A increases B and - B decreases A. -

- - + - - + + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Node ANode B + pubmed:24590577 + p(MGI:Chrm3) increases bp(GO:"pituitary gland development")
p(HGNC:TNF)a(CHEBI:nicotine)
bp(GO:"membrane depolarization")complex(GO:"NF-kappaB complex")
a(CHEBI:"amyloid-beta")p(HGNC:SYK)
bp(GO:"calcium ion homeostasis")complex(GO:"NF-kappaB complex")
p(HGNC:RELA)bp(GO:"long-term synaptic potentiation")
a(GO:synapse)p(HGNC:MAPT)
bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")a(CHEBI:"amyloid-beta")
p(HGNC:CHRNA7)complex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7))
complex(GO:"proteasome complex")a(CHEBI:"amyloid-beta")
p(HGNC:MAPT)bp(HP:Neurodegeneration)
bp(GO:autophagy)p(HGNC:SNCA)
bp(GO:"late endosomal microautophagy")p(MGI:Mapt)
a(CHEBI:"amyloid-beta")a(MESH:Microglia)
p(HGNC:HDAC6)p(HGNC:MAPT)
p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))a(HBP:"Tau aggregates")
bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")p(HGNC:MAPT)
p(MGI:Mapt, var("p.Pro301Leu"))bp(GO:macroautophagy)
p(HGNC:NFKB1)bp(GO:"long-term synaptic potentiation")
bp(GO:autophagy)p(HGNC:HTT, var("?"))
p(MGI:Cdk5r1)p(MGI:Cdk5)
a(CHEBI:"amyloid-beta")p(HGNC:CHRNA7)
p(HGNC:CHRNA7)a(CHEBI:"amyloid-beta")
bp(GO:autophagy)p(HGNC:MAPT)
a(CHEBI:"amyloid-beta")path(MESH:"Alzheimer Disease")
a(HBP:"Tau oligomers")a(HBP:"Tau aggregates")
p(HGNC:CHRNA7)a(CHEBI:anandamide)
complex(GO:"protein phosphatase type 2A complex")p(HGNC:GSK3B)
complex(GO:"NF-kappaB complex")a(CHEBI:"amyloid-beta")
path(MESH:Tauopathies)p(MGI:Tfeb)
p(FPLX:Proteasome)a(CHEBI:"amyloid-beta")
+ - + + + + pubmed:24590577 + + p(MGI:Chrm3) increases p(MGI:Prl) + + -

- Contradictory Pairs - 184 -

-

- These pairs of nodes have a contradiction in their causal relationships, meaning they - have more than one of INCREASES, DECREASES, or CAUSES NO - CHANGE. This may be due to different experimental conditions, so these statements - need to be carefully considered in analyses. -

- - + - - - + + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
SourceRelationsTarget + pubmed:24590577 + p(MGI:Chrm3) increases p(MGI:Gh)
a(CHEBI:epoxomicin)increases, decreasesp(HGNC:MAPT)
complex(GO:"protein phosphatase type 2A complex")increases, decreasesp(HGNC:MAPT, pmod(Ph))
path(MESH:"Alcohol Drinking")increases, causesNoChange, decreasesp(HGNC:ADNP)
complex(GO:"NF-kappaB complex")increases, decreasesp(HGNC:BCL2L1)
p(MGI:Chrna7)increases, decreasesp(MGI:Map2)
a(CHEBI:"Hsp90 inhibitor")increases, decreasesp(HGNC:MAPT)
a(CHEBI:ambroxol)increases, decreasesp(HGNC:SNCA)
bp(GO:autophagy)increases, decreasespath(HBP:neurotoxicity)
p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del"))negativeCorrelation, decreases, causesNoChangea(MESH:Microglia)
a(HBP:"Tau antibody, Tau46")causesNoChange, decreasesp(HGNC:MAPT)
p(HGNC:MAPT)increases, causesNoChangebp(GO:"retrograde axonal protein transport")
complex(p(HGNC:BACE1), p(HGNC:NFKB2), p(HGNC:RELA))increases, decreases, hasComponentp(HGNC:BACE1)
a(MESH:antalarmin)increases, decreasesp(RGD:Drd3)
a(MESH:antalarmin)causesNoChange, decreasespath(HBP:"isolation rearing")
a(GO:"neurofibrillary tangle")increases, decreasesbp(GO:"cell death")
a(MESH:antalarmin)increases, decreasesr(RGD:Ntrk2)
a(CHEBI:"methylene blue")increases, decreasesp(HGNC:MARK4)
p(HGNC:OTUB1)increases, decreasesp(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))
p(HGNC:TTBK2, var("p.Glu450*"))increases, decreasesp(HGNC:TTBK2)
p(HGNC:BSG)causesNoChange, decreasesa(CHEBI:"amyloid-beta")
p(HGNC:TTBK2, var("p.Asp449*"))increases, decreasesp(HGNC:TTBK2)
a(MESH:Nicotine)increases, decreasesp(MESH:"Receptors, GABA")
composite(a(CHEBI:chlorobutanol), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)))increases, decreasespath(MESH:Smell)
p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))increases, positiveCorrelation, decreasesp(HGNC:MAPT)
bp(MESH:Aging)increases, decreasesp(FPLX:HSP90)
path(MESH:"Amyotrophic Lateral Sclerosis")increases, association, negativeCorrelation, decreasesbp(GO:autophagy)
bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")increases, decreasesp(HGNC:PRNP)
a(MESH:"SNARE Proteins")increases, causesNoChangep(HGNC:CHRNA7)
p(HGNC:PRKN, var("?"))increases, decreasesp(HGNC:PRKN)
a(PUBCHEM:9832404)increases, decreasesr(HGNC:SLC17A7)
p(HGNC:STUB1)increases, decreasesp(FPLX:Caspase)
a(MESH:Nicotine)increases, decreasescomplex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))
p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))increases, causesNoChangepath(MESH:"Alcohol Drinking")
a(MESH:Astrocytes)increases, decreasesa(CHEBI:"amyloid-beta")
a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide")increases, decreasesa(CHEBI:"amyloid-beta polypeptide 42")
a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")increases, decreasesbp(HP:Neurodegeneration)
a(CHEBI:"Evans blue")increases, causesNoChangea(PUBCHEM:9832404)
p(HGNC:TTBK2, var("p.Tyr448*"))increases, decreasesp(HGNC:TTBK2)
a(CHEBI:sirolimus)increases, decreasesp(HGNC:HTT)
a(CHEBI:nicotine)increases, association, decreases, causesNoChange, regulatesp(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
r(HGNC:"BACE1-AS")increases, decreases, regulatesr(HGNC:BACE1)
a(PUBCHEM:675434)increases, decreasesp(HGNC:MAPT)
bp(GO:macroautophagy)increases, decreasesp(MGI:Mapt)
a(CHEBI:"amyloid-beta")causesNoChange, decreasespath(HBP:Neurodegeneration)
a(CHEBI:sirolimus)increases, decreasesp(HGNC:SNCA)
a(HBP:"Tau antibody, Tau46")causesNoChange, decreasesp(MGI:Mapt)
p(MGI:Chrna7)increases, decreasesa(CHEBI:"amyloid-beta")
a(CHEBI:"amyloid-beta")increases, positiveCorrelation, decreasescomplex(GO:"NF-kappaB complex")
path(HBP:"isolation rearing")increases, decreasesr(RGD:Bdnf)
a(HBP:"4-OH-GTS-21")causesNoChange, decreasesa(MESH:"Cholinergic Neurons")
a(CHEBI:"amyloid-beta")increases, decreasesa(MESH:"alpha7 Nicotinic Acetylcholine Receptor")
p(MGI:Vegfc)increases, causesNoChangea(CHEBI:macromolecule)
bp(GO:"chaperone-mediated autophagy")increases, causesNoChangep(MGI:Mapt, var("p.Pro301Leu"))
p(HGNC:MAPT)increases, association, causesNoChangea(HBP:"Tau aggregates")
bp(GO:macroautophagy)causesNoChange, decreasesp(MGI:Mapt, var("p.Pro301Leu"))
p(HGNC:TNF)increases, causesNoChangep(HGNC:STAT3, pmod(Ph))
a(MESH:antalarmin)increases, causesNoChangea(MESH:"Embryonic Structures")
p(HGNC:PICALM)increases, positiveCorrelation, decreasesa(CHEBI:"amyloid-beta")
a(CHEBI:Nilvadipine)increases, decreasesa(CHEBI:"amyloid-beta")
a(CHEBI:"amyloid-beta")increases, association, decreases, causesNoChange, positiveCorrelationp(HGNC:CHRNA7)
a(CHEBI:"methylene blue")increases, decreasesp(HGNC:SQSTM1)
a(CHEBI:"amyloid-beta")increases, decreasesbp(GO:memory)
complex(a(HBP:"Tau oligomers"), p(HGNC:HSPA1A))increases, decreasesbp(GO:"anterograde axonal protein transport")
p(HGNC:PIN1, pmod(Ph, Ser, 65))causesNoChange, decreasesp(HGNC:PIN1)
a(CHEBI:"chondroitin sulfate")causesNoChange, decreasesa(HBP:"Tau isoform F (441 aa)")
a(CHEBI:"dimethyl fumarate")increases, causesNoChangep(HGNC:NFE2L2)
bp(GO:"response to endoplasmic reticulum stress")increases, decreasesbp(GO:"cell death")
a(PUBCHEM:9832404)increases, association, causesNoChange, decreasesp(HGNC:DLG4)
a(CHEBI:rolipram)increases, decreasesp(HGNC:MAPT)
p(HGNC:BACE1)increases, association, causesNoChange, decreasesp(HGNC:APP)
p(FPLX:mTORC1)increases, decreasesbp(GO:macroautophagy)
p(HGNC:TARDBP)increases, decreasesp(HGNC:TFEB)
p(HGNC:MAPT)increases, causesNoChangebp(GO:"neuron death")
p(MGI:Chrna7)increases, decreasespath(MESH:"Spatial Memory")
p(HGNC:MAPT)increases, causesNoChangebp(GO:"anterograde axonal protein transport")
a(CHEBI:Thrombin)increases, causesNoChangep(HGNC:MAPT, frag("561_685"))
bp(GO:autophagy)increases, decreasesp(HGNC:MAPT)
path(MESH:"Alzheimer Disease")increases, association, positiveCorrelation, causesNoChangep(HGNC:MAPT)
p(HGNC:GSK3B)increases, decreases, directlyIncreasesp(HGNC:MAPT, pmod(Ph, Ser, 396))
a(CHEBI:sirolimus)increases, decreasesp(HGNC:MAPT)
p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))increases, causesNoChangep(MGI:Mapt)
p(HGNC:RRAGB)causesNoChange, decreasesp(HGNC:TFEB)
p(MGI:Crh)causesNoChange, decreasesa(MESH:Progesterone)
a(PUBCHEM:11249342)increases, causesNoChangepath(MESH:Nausea)
p(HGNC:RAB5A)increases, decreasesbp(GO:endocytosis)
p(HGNC:CDC37)increases, decreasesp(HGNC:MAPT)
p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))causesNoChange, decreasespath(MESH:"Motor Activity")
p(HGNC:CHAT)increases, decreases, directlyIncreasesa(CHEBI:acetylcholine)
a(CHEBI:rosiglitazone)increases, decreasesa(CHEBI:"amyloid-beta")
p(FPLX:mTORC1)increases, decreasesp(HGNC:TFEB)
p(HGNC:WNT3A)increases, decreasesa(CHEBI:"amyloid-beta")
p(HGNC:HSPA1A)increases, decreasesa(HBP:"Tau aggregates")
p(MGI:Mapt, var("p.Pro301Leu"))increases, decreasesp(MGI:Mapt)
p(HGNC:BACE1, frag("67_78"))increases, decreasesa(HBP:"sAPP-alpha")
a(HBP:"amyloid-beta oligomers")increases, decreasesp(HGNC:MAPT)
p(HGNC:OTUB1)regulates, increases, decreasesp(HGNC:MAPT)
path(MESH:"Alzheimer Disease")increases, association, decreases, negativeCorrelation, positiveCorrelationp(HGNC:CHRNA7)
a(CHEBI:nicotine)causesNoChange, decreasesa(CHEBI:"amyloid-beta")
path(MESH:"Alzheimer Disease")increases, association, decreases, negativeCorrelation, positiveCorrelationp(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
bp(GO:"lysosomal protein catabolic process")increases, decreasesa(CHEBI:"amyloid-beta")
bp(MESH:Autophagy)increases, decreasesp(HBP:"Tau C3")
a(MESH:antalarmin)increases, decreasesp(RGD:Drd2)
a(CHEBI:nicotine)increases, decreases, regulatesa(CHEBI:dopamine)
composite(a(PUBCHEM:9832404), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)))increases, decreasespath(MESH:Smell)
bp(GO:autophagy)increases, negativeCorrelation, decreasesa(CHEBI:lipid)
bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")causesNoChange, decreasesa(HBP:"protein aggregates")
p(HGNC:IDE)increases, decreasesa(CHEBI:"amyloid-beta")
a(CHEBI:nicotine)increases, causesNoChangea(HBP:"alpha-4-containing nAChR")
path(MESH:"Alzheimer Disease")increases, association, positiveCorrelation, decreasesa(CHEBI:"amyloid-beta")
a(CHEBI:Anatabine)increases, decreasespath(MESH:Anxiety)
p(MGI:Syk)increases, decreasesa(CHEBI:"amyloid-beta")
a(CHEBI:nicotine)increases, causesNoChange, regulatesp(FPLX:CHRN)
p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))causesNoChange, decreasesbp(MESH:"Hand Strength")
p(HGNC:TFEB)increases, decreases, regulatesa(CHEBI:"amyloid-beta")
p(HGNC:MAPT, var("p.Ala152Thr"))causesNoChange, decreasesp(HGNC:MAPT)
p(HGNC:ABCB1)increases, decreasesa(CHEBI:"amyloid-beta")
p(HGNC:BACE1, frag("228_236"))increases, decreasesa(HBP:"sAPP-alpha")
p(HGNC:AQP4)increases, association, decreasesa(CHEBI:"amyloid-beta")
bp(GO:aging)increases, negativeCorrelation, decreasesp(HGNC:MAPT)
a(CHEBI:heparin)causesNoChange, decreases, negativeCorrelationa(HBP:"Tau aggregates")
p(HGNC:MAPT)causesNoChange, decreases, negativeCorrelationa(GO:synapse)
p(MGI:Tfeb)causesNoChange, decreasesp(MGI:Mapt)
a(HBP:HBP00092)increases, causesNoChangebp(GO:"apoptotic process")
p(HGNC:ACHE)increases, decreases, directlyIncreasesa(CHEBI:acetylcholine)
a(PUBCHEM:675434)increases, causesNoChangep(FPLX:Proteasome)
a(CHEBI:tacrine)increases, decreasesp(HGNC:ACHE)
p(HGNC:IDE)increases, decreasesa(HBP:"alpha-synuclein fibrils")
p(MGI:Vegfc)increases, causesNoChangea(MESH:"Lymphatic Vessels")
p(HGNC:BCHE)decreases, directlyIncreasesa(CHEBI:acetylcholine)
a(CHEBI:nicotine)increases, decreasesp(HBP:"alpha-4 beta-2 nAChR")
p(MGI:Tfeb)causesNoChange, decreasesp(MGI:Mapt, pmod(Ph, Ser, 202))
path(MESH:D000544)causesNoChange, decreasesp(HGNC:ACHE)
bp(MESH:Autophagy)increases, decreasesa(HBP:"Tau aggregates")
path(MESH:"Alzheimer Disease")negativeCorrelation, decreases, causesNoChangep(HGNC:CHRNA3)
a(CHEBI:chloroquine)increases, decreasesp(HGNC:MAPT)
p(FPLX:"CCT_complex")increases, decreasesa(HBP:"huntingtin aggregates")
a(MESH:Kidney)increases, decreasesa(CHEBI:"amyloid-beta")
a(CHEBI:rosiglitazone)causesNoChange, decreasesa(HBP:HBP00018)
bp(GO:autophagy)increases, decreasesp(MESH:Proteins, pmod(HBP:misfolded))
p(HGNC:HSPB1)increases, causesNoChange, decreasesp(HGNC:MAPT)
a(PUBCHEM:11249342)increases, causesNoChangepath(MESH:Vomiting)
p(HGNC:NPEPPS)regulates, increases, decreasesp(HGNC:MAPT)
a(MESH:Nicotine)increases, decreasesp(HGNC:CHRNA7)
a(MESH:Liver)increases, decreasesa(CHEBI:"amyloid-beta")
a(CHEBI:chlorobutanol)causesNoChange, decreasespath(MESH:Smell)
p(MGI:Mapt, var("p.Ala152Thr"))increases, decreasesp(MGI:Mapt)
a(CHEBI:methamphetamine)increases, association, decreasesa(CHEBI:dopamine)
p(HGNC:CHRNA7)increases, association, decreases, regulates, positiveCorrelationa(CHEBI:"amyloid-beta")
a(CHEBI:nifedipine)increases, causesNoChangebp(GO:"calcium-mediated signaling")
a(HBP:HBP00055)increases, decreasesp(MGI:Mapt)
a(CHEBI:Nilvadipine)increases, decreasesa(CHEBI:"amyloid-beta polypeptide 42")
p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))causesNoChange, decreasesp(HGNC:SLC17A7)
p(HGNC:CHRM1)increases, causesNoChangebp(GO:"ERK1 and ERK2 cascade")
p(HGNC:SYK)increases, decreasesa(CHEBI:"amyloid-beta")
a(PUBCHEM:9832404)increases, causesNoChangep(HGNC:SLC17A7)
p(HGNC:MAPT)regulates, association, increases, causesNoChangebp(GO:"axonal transport")
p(MGI:Tfeb)causesNoChange, decreasesp(MGI:Mapt, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404))
p(HGNC:HTT, pmod(HBP:"O-GlcNAcylation"))increases, decreasesa(HBP:"huntingtin aggregates")
p(HGNC:STUB1)increases, decreasesp(HBP:"Tau C3")
a(CHEBI:"amyloid-beta")increases, decreasescomplex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))
bp(MESH:Autophagy)increases, causesNoChangep(HGNC:MAPT)
path(MESH:D060825)increases, causesNoChangep(HGNC:CHAT)
p(HBP:"Tau isoform B (381 aa)", pmod(HBP:glycation))increases, decreasesa(HBP:"Tau aggregates")
a(CHEBI:"amyloid-beta polypeptide 42")causesNoChange, decreasesp(FPLX:AMPK)
a(CHEBI:Anatabine)causesNoChange, decreasesbp(HBP:Astrogliosis)
p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))increases, decreasesp(HGNC:TFAP2B)
p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))causesNoChange, decreasespath(MESH:Smell)
a(CHEBI:Anatabine)causesNoChange, decreasesp(MGI:Tnf)
p(HGNC:CHRNA7)increases, decreases, regulatesa(CHEBI:"glutamate(2-)")
p(HGNC:VCP)increases, decreasescomplex(GO:"cytoplasmic stress granule")
a(CHEBI:lactacystin)increases, decreasesp(HGNC:MAPT)
a(HBP:"amyloid-beta oligomers")increases, decreasesp(HGNC:DLG4)
a(CHEBI:Anatabine)causesNoChange, decreasesp(MGI:Ifng)
p(FPLX:Proteasome)increases, decreasesp(HGNC:MAPT)
complex(a(GO:"proteasome complex"), p(HGNC:USP14))increases, decreasesbp(GO:"protein catabolic process")
a(CHEBI:"amyloid-beta")increases, decreasesa(CHEBI:acetylcholine)
p(HGNCGENEFAMILY:Proteasome)increases, decreasesp(MESH:Proteins, pmod(HBP:misfolded))
p(HBP:"Tau oligomers", var("p.Lys280del"))increases, causesNoChangebp(GO:"cell death")
a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide")increases, decreasesa(CHEBI:"amyloid-beta")
a(PUBCHEM:9576811)increases, decreasesp(HGNC:APP)
p(HGNC:MAPT)increases, association, causesNoChangea(HBP:"Tau fibrils")
complex(GO:"NF-kappaB complex")increases, decreases, regulatesp(HGNC:BACE1)
bp(MESH:"Oxidative Stress")increases, causesNoChangebp(GO:"apoptotic process")
path(HBP:"isolation rearing")increases, decreasesr(RGD:Ntrk2)
+ - + + + + pubmed:24590577 + + p(MGI:Chrm3) increases bp(GO:"multicellular organism growth") + + -

- Unstable Pairs - 128 -

-
-
Chaotic Pairs
-
Nodes that mutually increase each other, such as when both A increases - B and B increases A. -
-
Dampened Pairs
-
Nodes that mutually decrease each other, such as when both A decreases - B and B decreases A. -
-
-

- While neither chaotic nor dampened pairs are biologically invalid, they require - additional context to understand their regulation. -

- - + - - - + + - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
TypeNode ANode B + pubmed:24590577 + a(CHEBI:benzoxazine) decreases act(p(HGNC:CHRM4))
Chaoticp(HGNC:MAPT, pmod(Ac, Lys, 321))p(HGNC:MAPT, pmod(Ac, Lys, 321))
Chaoticcomplex(a(MESH:Ubiquitin), p(HGNC:UBA3))p(HGNC:UBA2)
Chaotica(CHEBI:"reactive oxygen species")complex(GO:"NF-kappaB complex")
Chaotica(CHEBI:"amyloid-beta")p(HGNC:RELA)
Chaoticp(FPLX:NFkappaB)p(HGNC:IL1B)
Chaoticp(FPLX:Proteasome)p(HGNC:CTNNB1, pmod(Ub))
Chaoticbp(GO:"microglial cell activation")p(HGNC:IL1B)
Chaotica(MESH:Neurons)p(HGNC:MAPT)
Chaoticbp(GO:"depolarization of postsynaptic membrane")bp(GO:"long-term synaptic potentiation")
Chaoticp(MGI:"oncostatin M")p(MGI:"signal transducer and activator of transcription 3")
Chaoticbp(GO:mitophagy)p(MESH:"parkin protein")
Chaoticcomplex(GO:"filamentous actin")p(HGNC:MAPT)
Chaotica(CHEBI:"amyloid-beta")p(HGNC:IL1B)
Chaotica(HBP:"Tau isoform F (441 aa)")a(HBP:"Tau isoform F (441 aa)")
Chaotica(CHEBI:"amyloid-beta")p(FPLX:TLR)
Chaotica(CHEBI:"amyloid-beta polypeptide 42")r(HGNC:"BACE1-AS")
Chaotica(HBP:"Tau aggregates")a(HBP:"Tau aggregates")
Chaoticp(MGI:"interleukin 1 alpha")p(MGI:"signal transducer and activator of transcription 3")
Chaotica(PUBCHEM:132157820)a(PUBCHEM:132157820)
Chaoticcomplex(a(GO:microtubule), p(HGNC:MAPT))p(HGNC:MAPT)
Chaotica(MESH:"Lymphatic Vessels")bp(MESH:"Cerebrovascular Circulation")
Chaoticp(HGNC:CHRNA7)p(HGNC:CHRNA7)
Chaotica(CHEBI:dextran)a(CHEBI:dextran)
Chaoticp(HBP:"N-terminal fragment of ATF6")p(HBP:"N-terminal fragment of ATF6")
Chaoticp(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B")p(MGI:"interleukin 1 alpha")
Chaoticbp(GO:"astrocyte activation")p(HGNC:IL18)
Chaoticbp(GO:"chaperone-mediated autophagy")p(MGI:Mapt, var("p.Pro301Leu"))
Chaotica(CHEBI:"amyloid-beta")p(HGNC:SYK)
Chaotica(CHEBI:acetylcholine)complex(a(CHEBI:acetylcholine), p(MESH:D011950))
Chaoticbp(GO:"microglial cell activation")p(HGNC:IL18)
Chaoticcomplex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1))p(HGNC:PPME1)
Chaotica(CHEBI:nicotine)p(HGNC:CHRNA7)
Chaotica(CHEBI:"amyloid-beta")p(HGNC:MMP9)
Chaoticcomplex(p(HGNC:CDK5), p(HGNC:CDK5R1))p(HGNC:CDK5)
Chaotica(CHEBI:"calcium(2+)")p(HGNC:CHRNA7)
Chaotica(CHEBI:acetylcholine)a(CHEBI:choline)
Chaotica(CHEBI:methamphetamine)p(HGNC:MTOR)
Chaoticp(HGNC:HSF1)p(HGNC:HSF1)
Chaotica(CHEBI:"amyloid-beta")p(HGNC:MMP3)
Chaotica(CHEBI:"amyloid-beta")bp(GO:phagocytosis)
Chaoticp(HGNC:PRNP)p(HGNC:PRNP)
Chaoticp(HBP:"Tau C3")p(HGNC:CASP3)
Chaoticcomplex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph)))p(HGNC:MAPT, pmod(Ph))
Chaotica(HBP:"Tau fibrils")p(MGI:Tfeb)
Chaotica(MESH:Proteins)p(HGNC:PSMD14)
Chaotica(CHEBI:"amyloid-beta")path(MESH:"Alzheimer Disease")
Chaoticp(HGNC:MAPT, pmod(Ac, Lys, 259))p(HGNC:MAPT, pmod(Ac, Lys, 259))
Chaoticcomplex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG))complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG))
Chaotica(CHEBI:"amyloid-beta")p(HGNC:MMP2)
Chaoticp(FPLX:NFkappaB)p(FPLX:NFkappaB)
Chaoticp(MESH:Proteins, pmod(Ub))p(MESH:Proteins, pmod(Ub))
Chaoticp(HGNC:MAPT, pmod(Ac, Lys, 353))p(HGNC:MAPT, pmod(Ac, Lys, 353))
Chaoticp(MGI:"interleukin 1 alpha")p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")
Chaoticp(HGNC:MAPT, var("p.Pro301Ser"))p(HGNC:MAPT, var("p.Pro301Ser"))
Chaoticcomplex(GO:"NF-kappaB complex")p(HGNC:IL6)
Chaoticcomplex(GO:"NF-kappaB complex")p(HGNC:TNF)
Chaotica(CHEBI:"amyloid-beta")complex(GO:"NF-kappaB complex")
Chaotica(MESH:"Neurofibrillary Tangles")p(HGNC:MAPT)
Chaotica(MESH:"Lymphatic Vessels")p(MGI:Vegfc)
Chaotica(CHEBI:nicotine)p(FPLX:"CAMK2_complex")
Chaotica(CHEBI:"amyloid-beta")p(HGNC:APP)
Chaoticcomplex(GO:"NF-kappaB complex")p(HGNC:CNTF)
Chaoticbp(GO:"chaperone-mediated autophagy")p(MGI:Mapt, var("p.Ala152Thr"))
Chaotica(CHEBI:"calcium(2+)")a(CHEBI:"calcium(2+)")
Chaotica(CHEBI:"amyloid-beta")p(HGNC:APOE)
Chaoticp(HBP:HBP00053, var("p.Ser262Ala"), var("p.Ser293Ala"), var("p.Ser324Ala"), var("p.Ser356Ala"))p(HBP:HBP00053, var("p.Ser262Ala"), var("p.Ser293Ala"), var("p.Ser324Ala"), var("p.Ser356Ala"))
Chaoticcomplex(GO:"NF-kappaB complex")p(HGNC:LIF)
Chaoticp(HGNC:ERN1)p(HGNC:ERN1, pmod(Ph))
Chaoticbp(MESH:"Unfolded Protein Response")p(MESH:Proteins, pmod(HBP:misfolded))
Chaotica(CHEBI:"amyloid-beta polypeptide 42")p(HGNC:TREM2)
Chaotica(CHEBI:"amyloid-beta")complex(GO:"NLRP3 inflammasome complex")
Chaoticp(HGNC:MAPT)p(HGNC:MAPT)
Chaoticp(MGI:Tfeb)p(MGI:Tfeb)
Chaotica(CHEBI:nicotine)bp(GO:"ERK1 and ERK2 cascade")
Chaoticp(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
Chaotica(MESH:Proteins)a(MESH:Proteins)
Chaotica(CHEBI:acetylcholine)p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")
Chaotica(CHEBI:acetylcholine)p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
Chaotica(GO:lysosome)a(GO:lysosome)
Chaotica(HBP:"amyloid-beta aggregates")path(MESH:"Alzheimer Disease")
Chaoticp(HGNC:MAPT, pmod(Ph, Tyr, 18))p(HGNC:SYK)
Chaotica(CHEBI:"amyloid-beta polypeptide 42")p(HGNC:AK1)
Chaotica(HBP:"Tau aggregates")p(HGNC:SYK)
Chaotica(HBP:"Tau aggregates")p(MGI:Mapt)
Chaoticbp(GO:"apoptotic process")p(HGNC:CASP6)
Chaotica(CHEBI:"reactive oxygen species")complex(GO:"NADPH oxidase complex")
Chaotica(HBP:"Tau oligomers")p(HGNC:MAPT)
Chaotica(CHEBI:nicotine)p(FPLX:PI3K)
Chaoticbp(GO:macroautophagy)p(MGI:Mapt, var("p.Ala152Thr"))
Chaotica(CHEBI:"amyloid-beta polypeptide 42")p(HGNC:BACE1)
Chaotica(CHEBI:"amyloid-beta")p(HGNC:CHRNA7)
Chaoticp(HGNC:MAPT)p(HGNC:SQSTM1)
Chaotica(CHEBI:acetylcholine)bp(GO:"synaptic transmission, cholinergic")
Chaoticp(HGNC:MAPT, pmod(Ac, Lys, 290))p(HGNC:MAPT, pmod(Ac, Lys, 290))
Chaoticbp(GO:"astrocyte activation")p(HGNC:IL1B)
Chaoticp(FPLX:NFkappaB)p(HGNC:TNF)
Dampenedp(HGNC:MAPT, pmod(Ac, Lys, 280))p(HGNC:MAPT, pmod(Ac, Lys, 280))
Dampeneda(CHEBI:"amyloid-beta")p(HGNC:BCL2L1)
Dampenedcomplex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE))complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE))
Dampenedp(HBP:"UBB+1", pmod(UbPoly))p(HBP:"UBB+1", pmod(UbPoly))
Dampenedp(HBP:"cis p-tau")p(HGNC:PIN1)
Dampeneda(HBP:"amyloid-beta derived diffusible ligands")a(HBP:"amyloid-beta derived diffusible ligands")
Dampenedp(HGNC:MAPT, pmod(Ac, Lys, 369))p(HGNC:MAPT, pmod(Ac, Lys, 369))
Dampenedp(HGNC:SIRT1)path(MESH:"Alzheimer Disease")
Dampeneda(CHEBI:"amyloid-beta")p(HGNC:CHRM1)
Dampeneda(HBP:"Tau aggregates")complex(GO:"proteasome complex")
Dampeneda(CHEBI:"amyloid-beta")complex(p(FPLX:"G_protein"), p(HGNC:CHRM1))
Dampenedp(HGNC:SNCA, var("?"))p(HGNC:SNCA, var("?"))
Dampenedp(MGI:Mapt, var("p.Pro301Leu"))p(MGI:Mapt, var("p.Pro301Leu"))
Dampeneda(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")
Dampenedp(HBP:"cis p-tau")p(HBP:"cis p-tau")
Dampeneda(CHEBI:"amyloid-beta")a(CHEBI:nicotine)
Dampenedp(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))
Dampeneda(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:nicotine)
Dampeneda(CHEBI:methamphetamine)bp(GO:autophagy)
Dampeneda(CHEBI:"amyloid-beta")p(HGNC:CHRNA7)
Dampenedp(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356))p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356))
Dampenedp(HGNC:MAPT, pmod(Ac, Lys, 281))p(HGNC:MAPT, pmod(Ac, Lys, 281))
Dampenedp(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu"))p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu"))
Dampenedcomplex(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7))complex(a(MESH:Bungarotoxins), p(HGNC:CHRNA7))
Dampenedbp(GO:autophagy)p(HGNC:MAPT)
Dampenedp(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212))p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212))
Dampenedp(HGNC:MAPT, pmod(Ac, Lys, 163))p(HGNC:MAPT, pmod(Ac, Lys, 163))
Dampeneda(CHEBI:acetylcholine)a(CHEBI:acetylcholine)
Dampenedp(MGI:Mapt, var("p.Ala152Thr"))p(MGI:Mapt, var("p.Ala152Thr"))
Dampenedp(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404))p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404))
Dampenedp(HBP:HBP00053, var("p.Lys280del"))p(HBP:HBP00053, var("p.Lys280del"))
Dampeneda(HBP:"protein aggregates")bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")
+ - + + + + pubmed:24590577 + + a(CHEBI:benzoxazine) decreases path(MESH:"Parkinson Disease") + + -

- Contradictory Triplets - 1492 -

-

- Analysis of triple stability comes from a deep graph theoretic background. It - identifies triangles within the graph that have logically inconsistent relations. -

-
-
Separately Unstable Triplet
-
When both A positiveCorrelation B, B negativeCorrelation - C, but C positiveCorrelation A. -
-
Mutually Unstable Triplets
-
When both A negativeCorrelation B, B negativeCorrelation - C, and C negativeCorrelation A. -
-
Jens Contradictory Triplet
-
When A increases B, A decreases C, and C - positiveCorrelation A. -
-
Increase Mismatch Triplet
-
When A increases B, A increases C, and C - negativeCorrelation A. -
-
Decrease Mismatch Triplet
-
When A decreases B, A decreases C, and C - negativeCorrelation A. -
-
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- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - 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TypeNode ANode BNode C + pubmed:30027901 + bp(GO:"response to drug") decreases path(HP:Irritability)
Separatepath(MESH:"Alzheimer Disease")p(HGNC:BAG1)p(HGNC:MAPT, pmod(Ph))
Separatepath(MESH:"Alzheimer Disease")complex(GO:"protein phosphatase type 2A complex")p(HGNC:SET, frag("?"))
Separatepath(MESH:"Pick Disease of the Brain")p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29))
Separatea(CHEBI:"amyloid-beta")p(HGNC:PICALM)path(MESH:"Alzheimer Disease")
Separatepath(MESH:"Alzheimer Disease")p(HGNC:MMP2)path(MESH:"Plaque, Amyloid")
Separatepath(MESH:"Alzheimer Disease")p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ph, Thr, 231))
Separatep(HGNC:MAPT, pmod(HBP:hyperphosphorylation))p(HGNC:CHRNA4)path(MESH:"Alzheimer Disease")
Separatepath(MESH:"Alzheimer Disease")complex(GO:"protein phosphatase type 2A complex")p(HGNC:SET)
Separatea(CHEBI:"amyloid-beta")bp(GO:endocytosis)path(MESH:"Alzheimer Disease")
Separatepath(MESH:"Alzheimer Disease")complex(GO:"protein phosphatase type 2A complex")p(HGNC:ANP32A)
Separatepath(MESH:"Alzheimer Disease")p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18))
Separatea(CHEBI:"amyloid-beta")p(HGNC:CHRNA7)path(MESH:"Alzheimer Disease")
Separatepath(MESH:Tauopathies)p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29))
Separatep(HGNC:MAPT, pmod(HBP:hyperphosphorylation))p(HGNC:CHRNA7)path(MESH:Schizophrenia)
Separatea(CHEBI:"amyloid-beta")p(HGNC:CHRNA4)path(MESH:"Alzheimer Disease")
Separatepath(MESH:"Alzheimer Disease")p(HGNC:MAPT)path(MESH:Dementia)
Separatepath(MESH:"Pick Disease of the Brain")p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18))
Separatepath(MESH:"Alzheimer Disease")p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ph, Tyr, 394))
Separatepath(MESH:"Alzheimer Disease")bp(GO:aging)p(HGNC:MAPT)
Separatepath(MESH:"Alzheimer Disease")p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29))
Separatepath(MESH:Tauopathies)p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18))
Separatep(HGNC:MAPT, pmod(HBP:hyperphosphorylation))p(HGNC:CHRNA7)path(MESH:"Alzheimer Disease")
Separatepath(MESH:"Alzheimer Disease")bp(GO:aging)p(HGNC:AGER)
Separatep(HGNC:CHRNA7)bp(GO:cognition)path(MESH:"Alzheimer Disease")
Separatea(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta polypeptide 42")path(MESH:"Alzheimer Disease")
Mutualbp(GO:"lysosomal protein catabolic process")bp(GO:endocytosis)path(MESH:"Alzheimer Disease")
Mutualbp(GO:autophagy)p(HGNC:MTOR)path(MESH:Schizophrenia)
Mutualbp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")bp(GO:autophagy)path(MESH:"Alzheimer Disease")
Mutualbp(GO:aging)complex(GO:"proteasome complex")p(HGNC:MAPT)
Mutualbp(GO:"proteasomal protein catabolic process")bp(GO:autophagy)path(MESH:"Alzheimer Disease")
Jensa(HBP:HBP00074)bp(GO:"neuron death")path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")bp(GO:"apoptotic process")p(HGNC:BCL2L1)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:sirolimus)bp(GO:macroautophagy)
Jensp(HGNC:MAPT)p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
Jensa(HBP:"Tau aggregates")a(HBP:"Tau oligomers")path(MESH:Tauopathies)
Jensa(GO:presynapse)a(PUBCHEM:64627)p(MGI:Adora1)
Jensa(HBP:"Tau aggregates")a(HBP:"Tau aggregates")p(HGNC:MAPT, frag("561_685"))
Jensa(CHEBI:"amyloid-beta")p(HGNC:ACE)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta polypeptide 42")a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine")bp(MESH:Neuroprotection)
Jensp(HGNC:FKBP5)p(HGNC:MAPT, pmod(Ph, Ser, 396))path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:RELA)
Jensp(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))p(HBP:HBP00053, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))
Jensp(HGNC:MAPT, pmod(Ac, Lys, 290))p(HGNC:MAPT, pmod(Ac, Lys, 290))p(HGNC:MAPT, pmod(Ac, Lys, 290))
Jensbp(MESH:Aging)p(FPLX:HSP90)p(FPLX:Proteasome)
Jensbp(GO:"cytoskeleton organization")p(FPLX:PPP2)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Jensp(HGNC:CDK2)p(HGNC:MAPT, pmod(Ph, Ser, 396))path(MESH:"Alzheimer Disease")
Jensp(HGNC:MAPT)p(HGNC:MAPT)p(HGNC:OTUB1)
Jensa(GO:"neurofibrillary tangle")bp(GO:"apoptotic process")p(HGNC:GSK3B)
Jensa(CHEBI:Calpeptin)bp(GO:autophagy)p(HGNC:CAPN1)
Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:"amyloid-beta")a(CHEBI:nicotine)
Jensa(CHEBI:nicotine)bp(GO:cognition)p(HGNC:CHRNA7)
Jensa(MESH:Neurons)a(PUBCHEM:64627)p(MGI:Adora1)
Jensbp(GO:macroautophagy)p(MGI:Mapt)p(MGI:Mapt, var("p.Ala152Thr"))
Jensbp(GO:autophagy)bp(MESH:Aging)p(FPLX:HSP90)
Jensa(CHEBI:nicotine)p(HGNC:CHRNA7)p(HGNC:JAK2)
Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:Nilvadipine)complex(GO:"NF-kappaB complex")
Jensa(HBP:HBP00089)bp(GO:"microglial cell activation")p(HGNC:IL1B)
Jensa(HBP:"Tau aggregates")p(HGNC:MAPT, pmod(Ac, Lys, 290))path(MESH:"Alzheimer Disease")
Jenscomplex(GO:"protein phosphatase type 2A complex")p(HGNC:SET)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:peroxynitrite)bp(GO:"inflammatory response")complex(GO:"NF-kappaB complex")
Jensp(HGNC:ABL1)p(HGNC:MAPT, pmod(Ph, Tyr, 394))path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"reactive oxygen species")p(FPLX:NFkappaB)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")bp(GO:memory)
Jensbp(GO:autophagy)p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:"amyloid-beta")complex(GO:"NF-kappaB complex")
Jensp(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:acetylcholine)p(HGNC:CHRNA7)
Jensa(CHEBI:nicotine)bp(GO:"MAPK cascade")p(FPLX:NFkappaB)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:donepezil)p(HGNC:CHRNA4)
Jensbp(GO:macroautophagy)p(HGNC:MAPT, pmod(Ph))p(HGNC:TREM2)
Jensbp(GO:macroautophagy)p(HGNC:MAPT, var("p.Ala152Thr"))p(MGI:Mapt)
Jensa(CHEBI:sirolimus)p(HGNC:SNCA)path(MESH:"Alzheimer Disease")
Jensbp(GO:"neuron death")p(HBP:RAC1b)p(MGI:Cdk5)
Jensa(HBP:"Tau oligomers")a(HBP:"Tau oligomers")path(HBP:neuroinflammation)
Jenscomplex(GO:"protein phosphatase type 2A complex")p(HGNC:CDK5)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Jensa(HBP:HBP00074)p(HGNC:NGFR)path(MESH:"Cognitive Dysfunction")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:pioglitazone)bp(GO:memory)
Jenspath(MESH:"Alzheimer Disease")path(MESH:"Cognitive Dysfunction")path(MESH:Thinking)
Jensa(MESH:Microglia)complex(GO:"NF-kappaB complex")p(HGNC:IL6)
Jensa(HBP:"Tau aggregates")p(HGNC:MAPT)path(HBP:Neurodegeneration)
Jensa(CHEBI:chloroquine)bp(GO:autophagy)p(HGNC:SQSTM1)
Jensa(GO:"neurofibrillary tangle")a(HBP:"Tau oligomers")path(MESH:"Alzheimer Disease")
Jensbp(GO:"long-term synaptic potentiation")p(HGNC:HSPB1)p(HGNC:MAPT)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:sirolimus)path(MESH:"Interpersonal Relations")
Jensa(CHEBI:"amyloid-beta")complex(GO:"NLRP1 inflammasome complex")p(HGNC:IL18)
Jensa(HBP:"Tau aggregates")path(MESH:"Alzheimer Disease")path(MESH:"Neurofibrillary Tangles")
Jensp(FPLX:Proteasome)p(HGNC:MAPT)p(HGNC:MAPT)
Jensa(CHEBI:"amyloid-beta")a(MESH:Astrocytes)p(MESH:Endopeptidases)
Jensa(GO:"neurofibrillary tangle")a(HBP:"Tau aggregates")p(HGNC:MAPT, pmod(Ph))
Jensa(HBP:"Tau aggregates")p(HGNC:MAPT, var("?"))path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")bp(GO:aging)p(HGNC:MAPT)
Jensa(MESH:"Amyloid beta-Peptides")p(HGNC:BECN1)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:chloroquine)p(HGNC:MAPT)p(HGNC:SQSTM1)
Jensa(CHEBI:galanthamine)p(HGNC:HMOX1)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide")a(CHEBI:"amyloid-beta polypeptide 42")p(HGNC:MAPT, pmod(Ph, Ser, 396))
Jensa(GO:"neurofibrillary tangle")a(HBP:"Tau aggregates")path(MESH:"Alzheimer Disease")
Jensa(HBP:"Tau aggregates")p(HGNC:MAPT, pmod(Ac, Lys, 321))path(MESH:"Alzheimer Disease")
Jensp(FPLX:HSP90)p(HGNC:MAPT, pmod(Ph))p(HGNC:PTGES3)
Jensa(CHEBI:"amyloid-beta")p(HGNC:IL18)path(MESH:"Alzheimer Disease")
Jensa(HBP:"protein aggregates")bp(GO:autophagy)path(HBP:Neurodegeneration)
Jensa(CHEBI:"amyloid-beta")a(MESH:Microglia)bp(GO:phagocytosis)
Jensa(PUBCHEM:132157820)a(PUBCHEM:132157820)a(PUBCHEM:132157820)
Jensa(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide")a(CHEBI:"amyloid-beta")r(HGNC:BACE1)
Jensa(CHEBI:"reactive oxygen species")bp(GO:"neuron death")path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"calcium(2+)")p(HGNC:CHRNA7)p(HGNC:CHRNA7)
Jensa(GO:autophagosome)p(HGNC:TARDBP)p(HGNC:TFEB)
Jensa(CHEBI:nicotine)bp(MESH:Neuroprotection)p(HGNC:CHRNA7)
Jensa(CHEBI:"methylene blue")p(HGNC:MAPT, pmod(Ph, Ser, 262))p(HGNC:MARK4)
Jensp(HGNC:CASP3)p(HGNC:MAPT)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"okadaic acid")bp(GO:cognition)p(HGNC:MAPT, pmod(Ph))
Jensa(CHEBI:"calcium(2+)")p(HGNC:MAPT)p(HGNCGENEFAMILY:Calpains)
Jensa(CHEBI:"calcium(2+)")a(CHEBI:"calcium(2+)")complex(p(HGNC:MAPT), p(HGNC:TGM2))
Jensa(HBP:"Tau aggregates")complex(GO:"proteasome complex")p(HGNC:MAPT)
Jensbp(MESH:Aging)p(FPLX:HSP90)p(HGNC:STIP1)
Jensa(CHEBI:"reactive oxygen species")bp(GO:"inflammatory response")complex(GO:"NF-kappaB complex")
Jensbp(GO:autophagy)p(FPLX:mTORC1)p(HGNC:TFEB)
Jensp(HGNC:MAPT, frag("?"))p(HGNC:MAPT, pmod(Ph, Ser, 422))path(MESH:"Alzheimer Disease")
Jensa(CHEBI:chloroquine)bp(GO:autophagy)p(HGNC:MAPT)
Jensa(CHEBI:"amyloid-beta")complex(GO:"NLRP3 inflammasome complex")p(HGNC:IL1B)
Jensa(GO:microtubule)p(HGNC:HDAC6)p(HGNC:MAPT)
Jensa(CHEBI:"amyloid-beta")a(GO:lysosome)complex(GO:"NLRP3 inflammasome complex")
Jensa(CHEBI:acetylcholine)a(CHEBI:acetylcholine)bp(GO:memory)
Jensbp(GO:cognition)p(HGNC:MAPT, pmod(Ph))p(HGNC:MTOR)
Jensp(HBP:"phosphatase-activating domain")p(HGNC:GSK3B)p(HGNC:MAPT, pmod(Ph, Ser, 199))
Jensa(MESH:"Neurofibrillary Tangles")p(HGNC:MAPT)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:Nilvadipine)p(HGNC:BACE1)
Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:"amyloid-beta")p(HGNC:CHRNA7)
Jensa(CHEBI:"amyloid-beta")a(MESH:Microglia)p(HGNC:TREM2, var("p.Arg47His"))
Jensp(HGNC:CDK5)p(HGNC:MAPT, pmod(Ph, Thr, 231))path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:Anatabine)p(HGNC:GSK3B, pmod(Ph, Ser, 9))
Jensa(CHEBI:"amyloid-beta")bp(GO:autophagy)p(HGNC:IL1B)
Jensa(CHEBI:sirolimus)complex(GO:"cytoplasmic stress granule")path(MESH:"Amyotrophic Lateral Sclerosis")
Jensa(CHEBI:"amyloid-beta")bp(GO:memory)complex(GO:"NF-kappaB complex")
Jensbp(GO:aging)p(HGNC:MAPT)p(HGNC:MAPT)
Jensp(HGNC:AK1)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))path(MESH:"Alzheimer Disease")
Jensp(FPLX:NFkappaB)p(FPLX:NFkappaB)p(FPLX:NFkappaB)
Jensa(CHEBI:galanthamine)p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")path(MESH:"Alzheimer Disease")
Jensa(CHEBI:sirolimus)bp(GO:macroautophagy)p(HGNC:SNCA)
Jenscomplex(GO:"protein phosphatase type 2A complex")p(FPLX:PPP2, pmod(Ph, Tyr, 307))p(HGNC:PTPA)
Jensbp(GO:"depolarization of postsynaptic membrane")complex(GO:"voltage-gated calcium channel complex")p(HBP:"alpha-4 beta-2 nAChR")
Jensa(CHEBI:"amyloid-beta")bp(GO:"JNK cascade")bp(GO:autophagy)
Jensbp(GO:"neuron death")complex(GO:"NF-kappaB complex")p(HGNC:IL1B)
Jensbp(GO:"neuron death")complex(GO:"NF-kappaB complex")p(HGNC:BACE1)
Jensa(CHEBI:dorsomorphin)p(FPLX:AMPK)p(HGNC:MAPT, pmod(Ph, Ser, 396))
Jensa(CHEBI:"amyloid-beta")a(CHEBI:rosiglitazone)bp(GO:"learning or memory")
Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:"amyloid-beta")bp(GO:endocytosis)
Jensa(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide")a(CHEBI:"amyloid-beta polypeptide 42")p(HGNC:MAPT, pmod(Ph, Ser, 404))
Jensa(GO:mitochondrion)bp(MESH:"Oxidative Stress")p(HGNC:GLP1R)
Jensa(CHEBI:sirolimus)p(HGNC:MAPT)path(MESH:"Alzheimer Disease")
Jensbp(GO:"neuron death")complex(GO:"NF-kappaB complex")p(HGNC:CXCL8)
Jensbp(GO:"axonal transport")p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))path(HBP:Neurodegeneration)
Jensp(HBP:"phosphatase-activating domain")p(HGNC:GSK3B)p(HGNC:MAPT, pmod(Ph, Ser, 202))
Jensbp(GO:mitophagy)p(HGNC:PRKN)p(HGNC:PRKN, var("?"))
Jensa(CHEBI:"amyloid-beta polypeptide 42")bp(GO:phagocytosis)p(HGNC:TREM2)
Jensa(CHEBI:nicotine)bp(GO:cognition)p(HBP:"alpha-4 beta-2 nAChR")
Jensbp(GO:"neuron death")path(HBP:Excitotoxicity)path(MESH:"Huntington Disease")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:acetylcholine)p(HGNC:CHRM2)
Jenscomplex(p(HGNC:MAPT), p(HGNC:MARK4))p(HGNC:MAPT, pmod(Ph, Ser, 262))path(MESH:"Alzheimer Disease")
Jensa(CHEBI:acetylcholine)a(CHEBI:nicotine)p(HGNC:CHRNA7)
Jensa(GO:"neurofibrillary tangle")p(HGNC:GSK3B)p(HGNC:MAPT, pmod(Ph))
Jensp(HGNC:TARDBP)path(MESH:"Frontotemporal Dementia")r(HGNC:LAMP1)
Jensa(CHEBI:"calcium(2+)")a(MESH:"Receptors, Nicotinic")p(HGNC:CHRNA7)
Jensa(HBP:"Tau aggregates")p(HGNC:MAPT)path(MESH:Tauopathies)
Jensa(HBP:"amyloid-beta oligomers")p(FPLX:Proteasome)p(HGNC:MAPT)
Jensa(HBP:"Tau oligomers")p(HGNC:MAPT)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")p(HGNC:IDE)path(MESH:"Alzheimer Disease")
Jenscomplex(GO:"protein phosphatase type 2A complex")p(FPLX:ERK)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:nicotine)path(MESH:Anxiety)
Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:resveratrol)bp(GO:"autophagosome assembly")
Jensa(CHEBI:acetylcholine)a(CHEBI:acetylcholine)p(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")
Jensa(HBP:"Tau aggregates")p(HGNC:MAPT, frag("?"))path(MESH:Tauopathies)
Jensp(HGNC:CDK5)p(HGNC:MAPT, pmod(Ph, Ser, 422))path(MESH:"Alzheimer Disease")
Jensa(CHEBI:epoxomicin)p(HGNC:CASP3)p(HGNC:MAPT)
Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:nicotine)bp(GO:"neuron death")
Jensbp(GO:learning)complex(GO:"NF-kappaB complex")path(MESH:"Alzheimer Disease")
Jensa(HBP:"alpha-synuclein aggregates")bp(GO:"neuron death")path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:fisetin)bp(GO:macroautophagy)
Jensa(GO:"neurofibrillary tangle")p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")p(HGNC:APOE)path(MESH:"Alzheimer Disease")
Jensa(MESH:"Cholinergic Neurons")bp(GO:memory)complex(GO:"NF-kappaB complex")
Jensa(CHEBI:"calcium(2+)")p(HGNC:CHRNA7)p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))
Jensp(FPLX:Proteasome)p(HGNC:MAPT)path(HBP:neurotoxicity)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:nicotine)p(FPLX:CHRN)
Jensbp(GO:"neuron death")p(HGNC:IL6)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:WNT3A)
Jensbp(GO:"neuron apoptotic process")p(HGNC:RELA)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(MGI:Syk)
Jensa(PUBCHEM:442534)bp(GO:memory)path(MESH:"Alzheimer Disease")
Jensbp(GO:autophagy)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))path(HBP:Neurodegeneration)
Jenscomplex(p(HGNC:GSK3B), p(HGNC:MAPT))p(HGNC:GSK3B)p(HGNC:MAPT)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:nicotine)p(FPLX:PI3K)
Jensa(CHEBI:nicotine)p(FPLX:PI3K)p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
Jensp(FPLX:PKA)p(HGNC:MAPT, pmod(Ph, Ser, 202))p(HGNC:SYK)
Jensa(CHEBI:acetylcholine)a(CHEBI:acetylcholine)bp(GO:"synaptic transmission, cholinergic")
Jensa(HBP:"alpha-synuclein aggregates")a(HBP:"alpha-synuclein fibrils")p(HGNC:IDE)
Jensbp(GO:"MAPK cascade")p(HBP:"alpha-4 beta-2 nAChR")path(MESH:"Alzheimer Disease")
Jensa(HBP:"Tau aggregates")a(HBP:"Tau oligomers")path(HBP:neurotoxicity)
Jensa(CHEBI:"amyloid-beta")p(HGNC:MME)path(MESH:"Plaque, Amyloid")
Jensp(FPLX:PPP2)p(HGNC:CDK5)path(MESH:"Alzheimer Disease")
Jensp(MGI:"interleukin 1 alpha")p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")p(MGI:"oncostatin M")
Jensp(HGNC:HSPB1)p(HGNC:MAPT)path(MESH:"Alzheimer Disease")
Jensp(FPLX:NFkappaB)p(FPLX:NFkappaB)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"reactive oxygen species")bp(GO:"inflammatory response")p(FPLX:NFkappaB)
Jensa(HBP:"Tau aggregates")complex(GO:"proteasome complex")p(HGNC:MAPT, pmod(Ph))
Jensa(HBP:"Tau aggregates")complex(a(GO:microtubule), p(HGNC:MAPT))p(HGNC:MAPT, var("p.Lys280del"))
Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:nicotine)p(HGNC:CHRNA7)
Jensa(CHEBI:chloroquine)p(HGNC:MAPT)p(HGNC:MAPT)
Jensa(CHEBI:"amyloid-beta")bp(MESH:"Neuronal Outgrowth")p(HGNC:APP)
Jensa(GO:"neurofibrillary tangle")p(HGNC:MAPT, pmod(Ph, Thr, 231))path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:Nilvadipine)p(HGNC:MAPT, pmod(Ph, Ser, 396))
Jensa(HBP:"Tau aggregates")complex(a(GO:microtubule), p(HGNC:MAPT))p(HGNC:MAPT, pmod(HBP:glycation))
Jensa(CHEBI:"amyloid-beta")a(CHEBI:nicotine)bp(GO:"neuron death")
Jensp(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B")p(MGI:"oncostatin M")path(MESH:Glioblastoma)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"calcium(2+)")a(CHEBI:acetylcholine)
Jensa(CHEBI:acetylcholine)bp(GO:"action potential initiation")p(HGNC:CHRNA7)
Jensbp(GO:"apoptotic process")p(HGNC:SNCA)p(HGNCGENEFAMILY:Calpains)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:nicotine)p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
Jensa(CHEBI:"amyloid-beta")bp(GO:"MAPK cascade")p(HGNC:CHRNA7)
Jensbp(GO:locomotion)composite(p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:DDC))p(HGNC:MAPT)
Jensa(CHEBI:"amyloid-beta")p(FPLX:CAPN)p(HGNC:MAPT)
Jensp(HGNC:MAPT)p(HGNC:MAPT)p(HGNC:TGM2)
Jensa(CHEBI:staurosporine)bp(GO:"apoptotic process")p(HGNC:CDK5)
Jensa(CHEBI:"okadaic acid")complex(GO:"protein phosphatase type 2A complex")p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Jensa(CHEBI:"amyloid-beta")a(HBP:HBP00018)path(MESH:"Alzheimer Disease")
Jensp(HGNC:MAPT)p(HGNC:MAPT, pmod(Ph))p(HGNC:TREM2)
Jensp(HGNC:CDC37)p(HGNC:CDK5)p(HGNC:MAPT, pmod(Ph, Ser, 404))
Jensa(CHEBI:acetylcholine)a(CHEBI:acetylcholine)complex(a(CHEBI:acetylcholine), p(MESH:D011950))
Jensbp(GO:cognition)p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
Jensbp(GO:"chaperone-mediated autophagy")p(MGI:Mapt, var("p.Ala152Thr"))p(MGI:Mapt, var("p.Ala152Thr"))
Jensbp(GO:autophagy)p(HGNC:MAPT)p(HGNC:SQSTM1)
Jensp(HGNC:CDK5)p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
Jensp(HGNC:MAPT, pmod(Ac, Lys, 369))p(HGNC:MAPT, pmod(Ac, Lys, 369))p(HGNC:MAPT, pmod(Ac, Lys, 369))
Jensbp(GO:"neuron death")p(HGNC:PARK7)path(MESH:"Parkinson Disease")
Jensa(CHEBI:donepezil)bp(GO:cognition)path(MESH:"Alzheimer Disease")
Jensbp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")p(HGNC:BAG1)p(HGNC:MAPT)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:rivastigmine)p(HGNC:ABCB1)
Jensa(HBP:"Tau oligomers")p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))path(MESH:"Alzheimer Disease")
Jensm(MIRBASE:"hsa-mir-146a")p(FPLX:NFkappaB)path(MESH:"Alzheimer Disease")
Jenscomplex(GO:"protein phosphatase type 2A complex")p(HGNC:ANP32A)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")p(MGI:Dyrk1a)path(MESH:Anxiety)
Jenscomplex(GO:"protein phosphatase type 2A complex")p(HGNC:MAPT, pmod(Ph))p(HGNC:PPP2CA)
Jensa(HBP:"Tau oligomers")p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ph))
Jensm(HGNC:MIR125B1)p(HGNC:CDKN2A)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")bp(GO:endocytosis)p(HGNC:APP)
Jensbp(GO:autophagy)p(HGNC:MAPT)path(HBP:neurotoxicity)
Jensa(CHEBI:galanthamine)bp(GO:"synaptic transmission, cholinergic")p(HGNC:ACHE)
Jensp(HGNC:IL1B)p(HGNC:PYCARD)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")a(HBP:HBP00038)complex(GO:"NLRP3 inflammasome complex")
Jensa(HBP:"Tau aggregates")complex(a(GO:microtubule), p(HGNC:MAPT))p(HGNC:MAPT)
Jensp(HGNC:MAPT, pmod(Ac, Lys, 280))p(HGNC:MAPT, pmod(Ac, Lys, 280))path(MESH:"Chronic Traumatic Encephalopathy")
Jensp(HBP:"4R tau")p(HGNC:TARDBP)path(MESH:"Frontotemporal Dementia")
Jensa(GO:"neurofibrillary tangle")p(HGNCGENEFAMILY:Transglutaminases)path(MESH:"Alzheimer Disease")
Jensa(PUBCHEM:9832404)bp(GO:"synaptic transmission, glutamatergic")p(HGNC:ADNP)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:Nilvadipine)complex(GO:"NF-kappaB complex")
Jensa(PUBCHEM:675434)p(HGNC:MAPT)p(HGNC:USP14)
Jensa(CHEBI:acrolein)p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:nicotine)bp(GO:"apoptotic process")
Jensp(HGNC:FYN)p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")bp(GO:aging)path(MESH:"Alzheimer Disease")
Jensp(HGNC:MAPT, pmod(Ac, Lys, 280))p(HGNC:MAPT, pmod(Ac, Lys, 280))path(HBP:"Corticobasal Degeneration")
Jensa(MESH:"Cholinergic Neurons")path(MESH:"Alzheimer Disease")path(MESH:Depression)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:donepezil)p(FPLX:CHRN)
Jensp(HGNC:MAPT)p(HGNC:NPEPPS)path(MESH:Tauopathies)
Jensp(HGNC:RELA)path(MESH:"Alzheimer Disease")r(HGNC:BACE1)
Jensa(CHEBI:"amyloid-beta")bp(GO:"cerebrospinal fluid circulation")bp(GO:aging)
Jensa(CHEBI:dextran)a(CHEBI:dextran)a(CHEBI:dextran)
Jensbp(GO:autophagy)p(HGNC:MAPT)p(HGNC:MAPT)
Jensa(CHEBI:"potassium(1+)")complex(GO:"inflammasome complex")p(HGNC:IL1B)
Jensa(CHEBI:"proteasome inhibitor")p(HGNC:BAG3)p(HGNC:MAPT)
Jensa(HBP:"amyloid-beta aggregates")p(HGNC:IDE)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:nicotine)p(FPLX:NFkappaB)
Jensa(CHEBI:rolipram)a(HBP:"Tau aggregates")p(HGNC:MAPT)
Jensa(CHEBI:"amyloid-beta")p(FPLX:JNK)p(HGNC:AGER)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")a(CHEBI:acetylcholine)
Jensbp(MESH:Aging)p(HGNC:PTGES3)path(MESH:"Protein Aggregation, Pathological")
Jenscomplex(GO:"proteasome complex")p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))p(HGNC:SQSTM1)
Jensa(HBP:"amyloid-beta oligomers")p(FPLX:Proteasome)path(HBP:neurotoxicity)
Jensp(HGNC:MAPT, pmod(Ph))p(HGNC:OGT)path(MESH:"Alzheimer Disease")
Jensa(HBP:"Tau oligomers")p(HGNC:MAPT, var("p.Ala152Thr"))path(MESH:"Supranuclear Palsy, Progressive")
Jensa(CHEBI:"3',5'-cyclic AMP")a(CHEBI:rolipram)p(HGNC:MAPT)
Jensa(HBP:"Tau aggregates")a(HBP:"Tau aggregates")p(MGI:Mapt)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")bp(GO:aging)
Jensa(CHEBI:acetylcholine)bp(GO:"synaptic transmission, cholinergic")p(HGNC:ACHE)
Jensa(CHEBI:"amyloid-beta")p(HGNC:DKK1)p(HGNC:WNT3A)
Jensa(HBP:"Tau oligomers")complex(GO:axon)p(HGNC:MAPT)
Jenscomplex(GO:"protein phosphatase type 2A complex")p(HGNC:CDK5)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:rivastigmine)p(HGNC:LRP1)
Jensbp(GO:macroautophagy)p(FPLX:mTORC1)p(HGNC:MAPT)
Jensp(HGNC:CHRNA7)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))path(MESH:"Alzheimer Disease")
Jensa(CHEBI:cilostazol)bp(GO:macroautophagy)p(FPLX:mTORC1)
Jensa(CHEBI:"alpha,alpha-trehalose")p(HGNC:BAG3)p(HGNC:MAPT)
Jensbp(GO:"MAPK cascade")p(HGNC:TNF)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:CHRNA4)
Jensp(HGNC:RNF19A)p(HGNC:SOD1, var("?"))path(MESH:"Amyotrophic Lateral Sclerosis")
Jensa(CHEBI:chlorobutanol)a(PUBCHEM:9832404)path(MESH:Smell)
Jensa(CHEBI:"amyloid-beta")bp(GO:autophagy)path(HBP:neurotoxicity)
Jensa(HBP:"Tau aggregates")a(HBP:"Tau aggregates")complex(GO:"proteasome complex")
Jensa(HBP:HBP00074)bp(GO:aging)path(MESH:"Alzheimer Disease")
Jensa(GO:presynapse)a(HBP:"Tau aggregates")a(MESH:"BSc 3094")
Jensa(CHEBI:"methylene blue")a(HBP:"Tau aggregates")bp(GO:macroautophagy)
Jensp(HGNC:MAPT, pmod(Ac, Lys, 280))p(HGNC:MAPT, pmod(Ac, Lys, 280))path(MESH:"Supranuclear Palsy, Progressive")
Jensp(HGNC:CDK5)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))path(MESH:Schizophrenia)
Jenscomplex(GO:"proteasome complex")p(FPLX:PKA)p(FPLX:PKA, pmod(Ub))
Jensa(CHEBI:"amyloid-beta")a(CHEBI:rosiglitazone)p(HGNC:PPARG)
Jenscomplex(a(GO:microtubule), p(HGNC:MAPT))p(HGNC:MAPT)p(HGNC:MAPT, var("?"))
Jensa(CHEBI:"methylene blue")bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")p(HGNC:MARK4)
Jensa(CHEBI:galanthamine)p(FPLX:CHRN)path(MESH:"Alzheimer Disease")
Jensp(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B")p(MGI:"interleukin 1 alpha")path(MESH:Glioblastoma)
Jensa(HBP:"Tau aggregates")p(HGNC:MAPT, pmod(Ph, Tyr))p(HGNC:SYK)
Jenscomplex(GO:"NF-kappaB complex")p(HGNC:BACE1)p(HGNC:TNF)
Jensbp(GO:autophagy)p(MESH:"PERK kinase")p(MESH:Proteins, pmod(HBP:misfolded))
Jensp(HGNC:BAG1)p(HGNC:MAPT)path(MESH:"Alzheimer Disease")
Jensp(FPLX:ERK)p(FPLX:NFkappaB)p(HGNC:TNF)
Jensa(CHEBI:"amyloid-beta")bp(GO:"long-term synaptic potentiation")p(MGI:Chrm1)
Jensa(MESH:D002800)bp(GO:"GO:0014047")path(MESH:D000544)
Jensa(HBP:"Tau aggregates")p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"okadaic acid")p(FPLX:PPP2)path(MESH:Neoplasms)
Jensp(FPLX:GSK3)p(HGNC:MAPT, pmod(Ph, Ser, 199))path(MESH:"Alzheimer Disease")
Jensbp(GO:"long-term synaptic potentiation")p(HGNC:MAPT)p(HGNC:MAPT)
Jenscomplex(a(GO:microtubule), p(HGNC:MAPT))p(HGNC:MAPT)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")bp(GO:endocytosis)
Jensa(CHEBI:"amyloid-beta")complex(p(HGNC:APP), p(HGNC:LRP1))p(HGNC:APP)
Jensa(CHEBI:nicotine)a(HBP:"alpha-4 beta-2 nAChR")a(MESH:"Dopaminergic Neurons")
Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:resveratrol)p(FPLX:AMPK)
Jensbp(GO:"neuron death")p(HGNC:IL1B)path(MESH:"Alzheimer Disease")
Jenscomplex(GO:"protein phosphatase type 2A complex")p(HGNC:GSK3B)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Jensbp(GO:autophagy)p(HGNC:FUS, var("?"))path(MESH:"Amyotrophic Lateral Sclerosis")
Jensa(CHEBI:"amyloid-beta")p(HGNC:IDE)p(HGNC:INS)
Jensa(HBP:"amyloid-beta oligomers")p(HGNC:MAPT)p(HGNC:MAPT)
Jensa(CHEBI:"amyloid-beta")p(HGNC:CHRNA7)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")bp(GO:"apoptotic process")p(HGNC:BCL2)
Jensa(CHEBI:lactacystin)p(FPLX:Proteasome)p(HGNC:MAPT)
Jensa(GO:"neurofibrillary tangle")p(HBP:"CDK5R1 p25")path(MESH:"Alzheimer Disease")
Jensp(HGNC:CTSD)p(HGNC:MAPT)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")p(HGNC:APP)p(HGNC:IL1B)
Jensa(CHEBI:heparin)a(HBP:"Tau aggregates")p(HGNC:MAPT, var("?"))
Jensa(CHEBI:nicotine)a(MESH:Neurons)p(MGI:Lynx1)
Jensa(HBP:"Tau oligomers")p(HGNC:MAPT)p(HGNC:OTUB1)
Jensp(HGNC:MAPT, pmod(Ph, Ser, 262))p(HGNC:MARK4)path(MESH:"Alzheimer Disease")
Jensa(PUBCHEM:377503130)p(FPLX:"CCT_complex")p(HGNC:HSF1)
Jensa(CHEBI:"potassium(1+)")p(HGNC:IL1B)p(HGNC:PYCARD)
Jensp(HGNC:CAPN2)p(HGNC:CAST)p(HGNC:HTT, var("?"))
Jensa(HBP:"Tau aggregates")a(MESH:Trehalose)bp(MESH:Autophagy)
Jensa(HBP:"Tau aggregates")bp(GO:aging)path(MESH:"Alzheimer Disease")
Jensp(HBP:"phosphatase-activating domain")p(HGNC:GSK3B)p(HGNC:MAPT, pmod(Ph, Thr, 205))
Jensa(CHEBI:"amyloid-beta")a(GO:synapse)bp(GO:endocytosis)
Jensa(HBP:"Tau aggregates")p(FPLX:PKA)p(HGNC:MAPT, pmod(Ph, Thr, 231))
Jensa(CHEBI:"amyloid-beta")bp(GO:"Fas signaling pathway")complex(GO:"NF-kappaB complex")
Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:Nilvadipine)p(HGNC:MAPT, pmod(Ph, Ser, 202))
Jensbp(GO:mitophagy)p(HGNC:PRKN)path(MESH:"Parkinson Disease")
Jensbp(GO:"long-term synaptic potentiation")p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ph, Thr, 205))
Jensa(CHEBI:"amyloid-beta")p(HGNC:BCL2)p(HGNC:TNF)
Jensa(CHEBI:donepezil)p(HGNC:CHRNA7)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")p(HGNC:BACE1)p(HGNC:TNF)
Jensa(HBP:"Tau aggregates")a(HBP:"Tau aggregates")bp(GO:aging)
Jensa(CHEBI:rivastigmine)bp(GO:cognition)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")path(MESH:"Alzheimer Disease")path(MESH:Inflammation)
Jensbp(GO:"motor neuron apoptotic process")p(HGNC:FUS, var("?"))path(MESH:"Amyotrophic Lateral Sclerosis")
Jensa(CHEBI:"amyloid-beta")p(HGNC:TARDBP)p(HGNC:TFEB)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:acetylcholine)p(HGNC:CHRM1)
Jensbp(MESH:Aging)p(FPLX:Proteasome)path(MESH:"Protein Aggregation, Pathological")
Jensa(CHEBI:sirolimus)bp(GO:autophagy)path(MESH:"Amyotrophic Lateral Sclerosis")
Jensa(HBP:"Tau oligomers")bp(GO:"mitochondrion organization")bp(HP:Neurodegeneration)
Jensa(CHEBI:acetylcholine)a(CHEBI:galanthamine)p(HGNC:ACHE)
Jensa(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide")a(CHEBI:"amyloid-beta")p(HGNC:SYK)
Jensbp(MESH:Aging)p(HGNC:AHSA1)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")bp(GO:autophagy)complex(GO:"inflammasome complex")
Jensa(HBP:"Tau aggregates")bp(GO:aging)p(HGNC:MAPT)
Jensa(HBP:"Tau oligomers")p(HGNC:MAPT)path(MESH:"Pick Disease of the Brain")
Jenscomplex(p(HGNC:APP), p(HGNC:HSD17B10))p(HGNC:HSD17B10)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")a(GO:lysosome)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:nicotine)p(HGNC:ACHE)
Jensp(HBP:"phosphatase-activating domain")p(HGNC:MAPT, pmod(Ph, Ser, 422))path(MESH:"Alzheimer Disease")
Jensp(MGI:Cdk5)p(MGI:Cdk5r1)p(MGI:Ttbk1)
Jensp(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))path(MESH:Tauopathies)
Jensa(HBP:"Tau oligomers")p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Jensa(HBP:"Tau aggregates")bp(GO:"lysosomal microautophagy")p(HGNC:MAPT, frag("?"))
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:APP)
Jensp(HGNC:IL6)p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))path(MESH:"Alzheimer Disease")
Jensbp(GO:"mitochondrion transport along microtubule")composite(p(HBP:"Tau C3"), p(HGNC:STUB1))p(HBP:"Tau C3")
Jensa(CHEBI:"alpha,alpha-trehalose")a(HBP:"Tau aggregates")bp(GO:macroautophagy)
Jensbp(GO:"neuron death")p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"lithium(1+)")bp(GO:autophagy)p(HGNC:MAPT)
Jensa(CHEBI:dopamine)a(HBP:HBP00093)path(MESH:"Parkinson Disease")
Jensp(HGNC:MAPT)p(HGNC:MAPT, pmod(Ac, Lys, 280))path(MESH:"Alzheimer Disease")
Jensa(GO:lysosome)p(HGNC:MAPT)path(MESH:"Alzheimer Disease")
Jensp(HGNC:MAPT)p(HGNC:MAPT, pmod(Ph))p(HGNC:MAPT, var("p.Lys280del"))
Jenscomplex(GO:"protein phosphatase type 2A complex")p(FPLX:ERK)p(HGNC:MAPT, pmod(Ph))
Jensa(CHEBI:"potassium(1+)")complex(GO:"NLRP3 inflammasome complex")p(HGNC:IL1B)
Jenscomplex(GO:"protein phosphatase type 2A complex")p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")p(HGNC:MAPT, pmod(Ph))p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
Jensa(CHEBI:"amyloid-beta")bp(GO:"lysosomal protein catabolic process")path(MESH:"Alzheimer Disease")
Jensbp(GO:"neuron death")complex(GO:"protein phosphatase type 2A complex")path(MESH:"Alzheimer Disease")
Jensa(GO:lysosome)g(HGNC:APP, var("?"))path(MESH:"Alzheimer Disease")
Jensp(HGNC:MAP1LC3B)p(HGNC:TARDBP)p(HGNC:TFEB)
Jensbp(GO:"neuron death")p(HGNC:MAPT, pmod(Ph))p(HGNC:MAPT, var("p.Ala152Thr"))
Jensa(CHEBI:nicotine)p(HGNC:CHRNA7)p(HGNC:CHRNA7)
Jensa(CHEBI:sirolimus)p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ph))
Jensa(GO:"neurofibrillary tangle")a(HBP:"Tau oligomers")bp(MESH:"Cell Survival")
Jensa(HBP:"alpha-synuclein aggregates")a(HBP:"alpha-synuclein fibrils")p(HGNC:SNCA, pmod(HBP:"O-GlcNAcylation", Thr, 72))
Jensa(CHEBI:"amyloid-beta")p(HGNC:FOLH1)path(MESH:"Alzheimer Disease")
Jensa(HBP:"Tau aggregates")bp(GO:aging)p(MGI:Mapt, pmod(HBP:hyperphosphorylation))
Jensa(CHEBI:"amyloid-beta polypeptide 42")a(MESH:Microglia)bp(GO:"positive regulation of advanced glycation end-product receptor activity")
Jensa(CHEBI:"amyloid-beta")bp(GO:"long-term synaptic potentiation")p(HGNC:FYN)
Jensp(HGNC:CDK5)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))path(MESH:"Alzheimer Disease")
Jensbp(GO:"neuron death")complex(GO:"NF-kappaB complex")p(HGNC:IL6)
Jensa(MESH:Neurons)p(HGNC:MAPT)p(HGNC:MAPT)
Jensa(CHEBI:"amyloid-beta")p(HGNC:MAPT, pmod(Ph))p(HGNC:MTOR)
Jensa(CHEBI:"amyloid-beta")complex(GO:"NLRP3 inflammasome complex")p(HGNC:IL18)
Jensbp(GO:autophagy)complex(GO:"ribonucleoprotein granule")p(HGNC:MAPT)
Jensp(MESH:Proteins, pmod(Ub))p(MESH:Proteins, pmod(Ub))p(MESH:Proteins, pmod(Ub))
Jensa(PUBCHEM:53340666)bp(GO:autophagy)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Jensa(CHEBI:nicotine)a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")bp(GO:"ERK1 and ERK2 cascade")
Jensp(HGNC:CHRNA7)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))path(MESH:Schizophrenia)
Jensa(CHEBI:Thrombin)a(HBP:"Tau aggregates")path(MESH:"Alzheimer Disease")
Jensp(HBP:"cis p-tau")p(HBP:"cis p-tau")p(HBP:"cis p-tau")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:nicotine)p(HGNC:CHRNA7)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:BCL2L1)
Jensbp(GO:"chaperone-mediated autophagy")p(MGI:Mapt, var("p.Pro301Leu"))p(MGI:Mapt, var("p.Pro301Leu"))
Jensa(CHEBI:resveratrol)p(HGNC:CAMKK2)p(HGNC:MAPT, pmod(Ph))
Jensa(CHEBI:"amyloid-beta")bp(GO:autophagy)p(HGNC:TFEB)
Jensp(HGNC:CTSD)p(HGNC:MAPT)path(HBP:neurotoxicity)
Jensa(CHEBI:"glutamate(2-)")p(HGNC:CHRNA7)p(HGNC:CHRNA7)
Jensa(CHEBI:acetylcholine)a(MESH:"Cholinergic Neurons")bp(GO:memory)
Jensa(HBP:"Tau oligomers")p(HGNC:MAPT)p(HGNC:MAPT)
Jensa(HBP:HBP00018)path(MESH:"Alzheimer Disease")path(MESH:"Plaque, Amyloid")
Jensbp(GO:autophagy)p(HGNC:TARDBP, var("?"))path(MESH:"Amyotrophic Lateral Sclerosis")
Jensa(CHEBI:"amyloid-beta")p(HGNC:APP)p(HGNC:WNT3A)
Jensa(CHEBI:"amyloid-beta")bp(GO:"neuron death")bp(GO:proteolysis)
Jensp(HBP:"phosphatase-activating domain")p(HGNC:MAPT, pmod(Ph, Ser, 202))path(MESH:"Alzheimer Disease")
Jensbp(GO:autophagy)bp(MESH:"Unfolded Protein Response")p(MESH:Proteins, pmod(HBP:misfolded))
Jensa(HBP:"Tau oligomers")bp(GO:cognition)path(HBP:Neurodegeneration)
Jensa(MESH:Proteins)a(MESH:Proteins)p(HGNC:PSMD14)
Jensa(CHEBI:"amyloid-beta")bp(GO:"cell death")p(HGNC:CHRM1)
Jensa(CHEBI:rolipram)a(HBP:"Tau aggregates")complex(GO:"proteasome complex")
Jensp(HGNC:BACE1)p(HGNC:RELA)path(MESH:"Alzheimer Disease")
Jensp(FPLX:ERK)p(HGNC:MAPT, pmod(Ph, Ser, 202))path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one")bp(GO:memory)
Jensbp(GO:"chaperone-mediated autophagy")p(MGI:Mapt)p(MGI:Mapt, var("p.Ala152Thr"))
Jensp(HGNC:BAG1)p(HGNC:MAPT)p(HGNC:MAPT)
Jensa(CHEBI:"alpha,alpha-trehalose")bp(GO:autophagy)p(HGNC:MAPT)
Jensbp(GO:"apoptotic process")p(FPLX:ERK)p(HGNC:CDK5)
Jensa(CHEBI:epoxomicin)p(FPLX:Proteasome)p(HGNC:MAPT)
Jensa(CHEBI:"amyloid-beta")bp(MESH:"Oxidative Stress")path(MESH:"Alzheimer Disease")
Jensbp(GO:"mitochondrion transport along microtubule")composite(p(HBP:"Tau isoform F (441 aa)"), p(HGNC:STUB1))p(HBP:"Tau isoform F (441 aa)")
Jensp(HGNC:MAPT, pmod(Ac, Lys, 259))p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
Jensa(HBP:"Tau aggregates")a(HBP:"Tau oligomers")path(MESH:"Alzheimer Disease")
Jensa(CHEBI:epoxomicin)p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356))p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356))
Jensa(CHEBI:"amyloid-beta")bp(GO:"lysosomal microautophagy")complex(GO:"TOR complex")
Jensa(MESH:methyllycaconitine)bp(MESH:Neuroprotection)p(HGNC:CHRNA7)
Jensa(CHEBI:nicotine)bp(GO:"ERK1 and ERK2 cascade")p(FPLX:NFkappaB)
Jensa(GO:"neurofibrillary tangle")a(HBP:"Tau aggregates")a(HBP:"Tau aggregates")
Jensa(HBP:"Tau aggregates")bp(MESH:Autophagy)p(HGNC:MAPT, pmod(Ph))
Jensp(HGNC:MAPT, pmod(Ac, Lys, 321))p(HGNC:MAPT, pmod(Ac, Lys, 321))p(HGNC:MAPT, pmod(Ac, Lys, 321))
Jensa(CHEBI:"alpha,alpha-trehalose")a(CHEBI:"amyloid-beta")bp(GO:macroautophagy)
Jensp(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B")p(MGI:"interleukin 1 alpha")p(MGI:"oncostatin M")
Jensa(PUBCHEM:71361092)p(FPLX:PPP2)path(MESH:Neoplasms)
Jensp(HGNC:MAPT)p(HGNC:MAPT)p(HGNC:MAPT)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"reactive oxygen species")path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")p(HGNC:BACE1)path(MESH:"Alzheimer Disease")
Jensp(HGNC:CHAT)path(MESH:"Alzheimer Disease")path(MESH:Dementia)
Jensbp(GO:"neuron apoptotic process")p(HGNC:PPID)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")a(GO:lysosome)p(HGNC:TFEB)
Jensa(CHEBI:"amyloid-beta")a(MESH:"Cerebrospinal Fluid")p(HGNC:AQP1)
Jensa(HBP:"Tau aggregates")p(HGNC:MAPT, pmod(OGlyco))path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:nicotine)a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")
Jensa(CHEBI:"amyloid-beta")complex(GO:"NF-kappaB complex")path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")complex(GO:"NF-kappaB complex")complex(a(GO:"membrane attack complex"), p(HGNC:C5))
Jensa(HBP:"Tau oligomers")p(HGNC:MAPT, var("?"))path(MESH:"Alzheimer Disease")
Jensp(HGNC:MAPT, pmod(Ac, Lys, 280))p(HGNC:MAPT, pmod(Ac, Lys, 280))path(MESH:"Frontotemporal Dementia")
Jensa(CHEBI:"amyloid-beta")p(HGNC:MAPT, pmod(Ph))path(HBP:Neurodegeneration)
Jensa(GO:microtubule)a(HBP:"Tau oligomers")p(HGNC:MAPT)
Jensbp(GO:"neuron death")p(HGNC:MAPT)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")complex(GO:"inflammasome complex")p(HGNC:IL1B)
Jensp(HBP:HBP00053, var("p.Ser262Ala"), var("p.Ser293Ala"), var("p.Ser324Ala"), var("p.Ser356Ala"))p(HBP:HBP00053, var("p.Ser262Ala"), var("p.Ser293Ala"), var("p.Ser324Ala"), var("p.Ser356Ala"))p(HBP:HBP00053, var("p.Ser262Ala"), var("p.Ser293Ala"), var("p.Ser324Ala"), var("p.Ser356Ala"))
Jensa(CHEBI:"torin 1")p(FPLX:mTORC1)p(HGNC:TFEB)
Jensa(CHEBI:wortmannin)bp(GO:autophagy)p(HGNC:MAPT)
Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:nicotine)a(HBP:"alpha-4 beta-2 nAChR")
Jensa(CHEBI:sirolimus)p(HGNC:MAPT)path(MESH:Tauopathies)
Jenscomplex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE))complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE))complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNE))
Jensa(CHEBI:"amyloid-beta")bp(MESH:"Neuronal Outgrowth")p(MGI:Chrna7)
Jenscomplex(p(HGNC:GSK3B), p(HGNC:MAPT))p(HGNC:MAPT)p(HGNC:MAPT)
Jensbp(GO:"ERAD pathway")p(HGNC:ATF6)p(MESH:Proteins, pmod(HBP:misfolded))
Jensp(HGNC:MAPT, pmod(Ph, Ser, 356))p(HGNC:MARK4)path(MESH:"Alzheimer Disease")
Jensp(HGNC:MAPT)p(HGNC:MAPT, pmod(Ac, Lys, 280))path(MESH:"Frontotemporal Dementia")
Jensp(HGNC:SNCA)p(HGNC:SNCA, pmod(Ub))path(MESH:"Parkinson Disease")
Jensp(HGNC:LAMP1)p(HGNC:TARDBP)path(MESH:"Frontotemporal Dementia")
Jenscomplex(GO:axon)p(HGNC:MAPT)p(HGNC:MAPT)
Jensbp(GO:aging)p(HGNC:FKBP5)p(HGNC:MAPT)
Jensp(HGNC:MAPT)p(HGNC:MAPT, pmod(Ph, Thr, 205))path(MESH:"Alzheimer Disease")
Jensbp(GO:cognition)p(HGNC:FYN)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:galanthamine)bp(GO:cognition)p(HGNC:CHRNA7)
Jensa(HBP:"Tau aggregates")p(HGNC:MAPT, frag("?"))path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")bp(GO:"neuron death")p(HGNC:RAB5A)
Jensp(HGNC:MAPT, pmod(HBP:hyperphosphorylation))p(HGNC:MARK4)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:palbociclib)a(HBP:"Tau isoform F (441 aa)")p(HGNC:CDK6)
Jensa(CHEBI:lipid)bp(GO:endocytosis)p(HGNC:RAB5A)
Jensbp(GO:"proteasomal protein catabolic process")p(HGNC:HSPB1)p(HGNC:MAPT)
Jensa(CHEBI:"amyloid-beta")bp(GO:"canonical Wnt signaling pathway")p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu"))
Jensp(HGNC:FKBP5)p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
Jensp(HGNC:MAPT)p(HGNC:MAPT, pmod(Ph, Ser, 404))path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"calcium(2+)")a(CHEBI:acetylcholine)p(HGNC:CHRNA7)
Jensbp(GO:"neuron death")p(HGNC:CASP3)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HBP:"Tau aggregates")
Jensa(CHEBI:geldanamycin)p(FPLX:HSP90)p(HGNC:HSF1)
Jensbp(GO:autophagy)p(HGNC:HTT, var("?"))path(MESH:"Huntington Disease")
Jensa(CHEBI:acetylcholine)a(CHEBI:nicotine)p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
Jensa(HBP:"Tau oligomers")p(HGNC:MAPT)p(HGNC:MAPT, var("?"))
Jensa(PUBCHEM:155160)bp(GO:memory)p(HGNC:BACE1)
Jensa(CHEBI:"amyloid-beta")a(MESH:Astrocytes)a(MESH:Microglia)
Jensa(CHEBI:"amyloid-beta")a(PUBCHEM:136299192)bp(GO:"long-term synaptic potentiation")
Jensa(HBP:HBP00074)path(MESH:"Alzheimer Disease")path(MESH:Dementia)
Jensa(CHEBI:"calcium(2+)")a(CHEBI:acetylcholine)p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
Jensa(CHEBI:"amyloid-beta")bp(MESH:"Oxidative Stress")p(HGNC:MAPT)
Jensp(FPLX:ERK)p(FPLX:NFkappaB)path(MESH:"Alzheimer Disease")
Jensa(HBP:"Tau aggregates")complex(a(GO:microtubule), p(HGNC:MAPT))p(HGNC:MAPT, var("p.Arg406Trp"))
Jensp(HGNC:FKBP5)p(HGNC:MAPT, pmod(Ph, Ser, 199))path(MESH:"Alzheimer Disease")
Jensp(HGNC:MAPT, pmod(Ph))p(HGNC:MAPT, pmod(Sumo, Lys, 340))p(HGNC:MAPT, pmod(Ub))
Jensa(CHEBI:"calcium(2+)")a(CHEBI:nicotine)p(HGNC:CHRNA7)
Jensa(CHEBI:"amyloid-beta polypeptide 42")complex(GO:"NF-kappaB complex")path(HBP:neurotoxicity)
Jensa(CHEBI:acetylcholine)a(CHEBI:acetylcholine)a(CHEBI:choline)
Jensa(CHEBI:epoxomicin)p(HGNC:MAPT)p(HGNC:MAPT)
Jensp(HBP:"4R tau")p(HGNC:SRSF2)path(MESH:"Supranuclear Palsy, Progressive")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:sirolimus)p(HGNC:MAPT)
Jensbp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")p(HGNC:MAPT)path(MESH:Tauopathies)
Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:"amyloid-beta")a(CHEBI:rosiglitazone)
Jensp(HGNC:CDK5)p(HGNC:MAPT, pmod(Ph, Ser, 404))path(MESH:"Alzheimer Disease")
Jensa(HBP:"Tau aggregates")p(HGNC:MAPT, pmod(Ph))p(HGNC:MAPT, var("p.Lys280del"))
Jensa(CHEBI:scopolamine)a(MESH:"1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid")bp(GO:"behavioral fear response")
Jensa(MESH:Lysosomes)p(HGNC:MAPT)path(MESH:"Alzheimer Disease")
Jensp(HGNC:MAPT)p(HGNC:MAPT, pmod(Ph))path(HBP:Neurodegeneration)
Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:rosiglitazone)a(MESH:Microglia)
Jensp(HGNC:MME)path(MESH:"Alzheimer Disease")path(MESH:"Plaque, Amyloid")
Jensa(CHEBI:"amyloid-beta")a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")a(MESH:Microglia)
Jensa(CHEBI:"amyloid-beta")path(MESH:"Alzheimer Disease")path(MESH:"Plaque, Amyloid")
Jensa(HBP:"Tau aggregates")complex(GO:"proteasome complex")p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Jensbp(GO:"neuron death")path(MESH:"Huntington Disease")path(MESH:Atrophy)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:Nilvadipine)p(HGNC:APP)
Jensbp(GO:autophagy)p(FPLX:AMPK)p(FPLX:mTORC1)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:donepezil)p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
Jensa(CHEBI:"amyloid-beta")a(MESH:Microglia)p(HGNC:MAPT)
Jensp(HGNC:APP, frag("672_711"))p(HGNC:BACE1)path(MESH:"Alzheimer Disease")
Jensa(HBP:"Tau aggregates")p(HBP:"cis p-tau")path(MESH:"Alzheimer Disease")
Jenscomplex(a(GO:microtubule), p(HGNC:MAPT))p(HGNC:MAPT)p(HGNC:MAPT)
Jensp(MGI:Tfeb)p(MGI:Tfeb)p(MGI:Tfeb)
Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:"amyloid-beta")a(CHEBI:Nilvadipine)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:donepezil)p(HGNC:BCL2)
Jensa(CHEBI:"amyloid-beta")bp(GO:"JNK cascade")complex(GO:"NF-kappaB complex")
Jensa(CHEBI:galanthamine)p(FPLX:NFkappaB)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:acetylcholine)p(FPLX:CHRN)
Jensa(GO:"neurofibrillary tangle")p(HGNC:CDKN2A)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")p(HGNC:APP)p(HGNC:SUMO3)
Jensa(CHEBI:"reactive oxygen species")bp(GO:"neuron death")complex(GO:"NF-kappaB complex")
Jensp(HBP:HBP00065)path(MESH:"Alzheimer Disease")path(MESH:"Plaque, Amyloid")
Jensa(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide")p(MGI:App, frag("25_35"))path(MESH:"Spatial Memory")
Jensa(CHEBI:"amyloid-beta")bp(GO:"apoptotic process")complex(GO:"NF-kappaB complex")
Jenscomplex(GO:"filamentous actin")p(HGNC:MAPT)p(HGNC:MAPT)
Jensa(CHEBI:"calcium(2+)")bp(MESH:"Oxidative Stress")p(HGNC:S100B)
Jensp(MGI:Mapt, var("p.Ala152Thr"))p(MGI:Mapt, var("p.Ala152Thr"))p(MGI:Mapt, var("p.Ala152Thr"))
Jensp(HGNC:MAPT, pmod(Ac, Lys, 281))p(HGNC:MAPT, pmod(Ac, Lys, 281))p(HGNC:MAPT, pmod(Ac, Lys, 281))
Jensa(HBP:"Tau oligomers")complex(GO:"proteasome complex")path(HBP:Neurodegeneration)
Jensa(CHEBI:"amyloid-beta")bp(MESH:"Oxidative Stress")complex(GO:"NF-kappaB complex")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:acetylcholine)a(CHEBI:nicotine)
Jensa(CHEBI:Calpeptin)p(HGNC:CAPN1)p(HGNC:HTT, var("?"))
Jensbp(GO:memory)p(HGNC:SIRT1)path(MESH:"Alzheimer Disease")
Jensp(HGNC:MAPT, pmod(HBP:hyperphosphorylation))p(HGNC:MAPT, var("?"))path(MESH:"Alzheimer Disease")
Jensp(HGNC:CDK5)p(HGNC:MAPT, pmod(Ph, Ser, 199))path(MESH:"Alzheimer Disease")
Jenscomplex(GO:"NF-kappaB complex")p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")p(HGNC:CHRNA7)p(HGNC:CHRNA7)
Jensbp(MESH:Neuroprotection)p(HGNC:CHRNA7)p(HGNC:JAK2)
Jenscomplex(a(GO:microtubule), p(HGNC:MAPT))complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A))p(HGNC:MAPT, pmod(Ph))
Jensbp(GO:autophagy)p(FPLX:mTORC1)p(HGNC:ULK1, pmod(Ph))
Jensa(CHEBI:ceramide)complex(GO:"protein phosphatase type 2A complex")path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:acetylcholine)p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
Jensa(CHEBI:acetylcholine)p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")path(MESH:"Alzheimer Disease")
Jensa(GO:lysosome)a(GO:lysosome)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:sirolimus)bp(MESH:Autophagy)p(HGNC:MAPT)
Jensa(CHEBI:"amyloid-beta")a(MESH:"1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo(d)imidazol-2-(3H)-one")p(HGNC:CHRM1)
Jensp(HGNC:GRIK2)p(HGNC:GRIK2)p(HGNC:GRIK2)
Jensa(MESH:Lysosomes)bp(MESH:Proteolysis)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")bp(GO:"lysosomal protein catabolic process")bp(GO:autophagy)
Jensa(CHEBI:"amyloid-beta polypeptide 42")complex(GO:"NF-kappaB complex")p(HGNC:BACE1)
Jensp(HGNC:PRKN)p(HGNC:SNCA)path(MESH:"Parkinson Disease")
Jensbp(GO:autophagy)complex(GO:"proteasome complex")p(HGNC:MAPT)
Jensa(MESH:Trehalose)bp(MESH:Autophagy)p(HGNC:MAPT)
Jensa(CHEBI:sirolimus)bp(GO:autophagy)p(HGNC:MAPT, pmod(Ph))
Jensa(CHEBI:"amyloid-beta")p(HGNC:BACE1)p(HGNC:CHRM1)
Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:"amyloid-beta")path(HBP:neurotoxicity)
Jensp(HGNC:GSK3B)p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ph, Ser, 404))
Jensp(HGNC:CDC37)p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ph, Ser, 404))
Jensa(CHEBI:curcumin)bp(GO:macroautophagy)p(FPLX:mTORC1)
Jensa(GO:"neurofibrillary tangle")p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
Jensbp(GO:aging)p(HGNC:IL18)path(MESH:"Alzheimer Disease")
Jensp(HGNC:CTSD)p(HGNC:MAPT)path(MESH:"Frontotemporal Dementia")
Jensa(CHEBI:"methylene blue")a(HBP:"Tau aggregates")bp(MESH:Autophagy)
Jensp(HGNC:MAPT)p(HGNC:MAPT)p(HGNC:SQSTM1)
Jensa(MESH:"Amyloid beta-Peptides")p(HGNC:TNF)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")path(MESH:"Alzheimer Disease")r(HGNC:BACE1)
Jensp(HGNC:MAPT, pmod(Ph))p(HGNC:MTOR)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:simvastatin)bp(GO:"ERK1 and ERK2 cascade")bp(GO:"apoptotic process")
Jensa(CHEBI:"amyloid-beta")p(HGNC:LRP1)path(MESH:Sleep)
Jensa(MESH:"Amyloid beta-Peptides")complex(GO:"NF-kappaB complex")path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:Temsirolimus)bp(GO:macroautophagy)
Jensp(HGNC:ITPKB)path(MESH:"Alzheimer Disease")path(MESH:"Plaque, Amyloid")
Jensp(HGNC:GSK3B)p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ph, Thr, 205))
Jensbp(GO:"chaperone-mediated autophagy")bp(MESH:Aging)path(MESH:"Protein Aggregation, Pathological")
Jensbp(GO:"neuron death")p(HGNC:BACE1)path(MESH:"Alzheimer Disease")
Jensa(HBP:HBP00018)a(HBP:HBP00030)path(MESH:"Alzheimer Disease")
Jensa(GO:"neurofibrillary tangle")p(HGNC:GSK3B)p(HGNC:MAPT, pmod(Ph, Thr, 231))
Jensp(HGNC:MAPT, pmod(Ph))p(HGNC:TNF)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:"amyloid-beta")r(HGNC:"BACE1-AS")
Jensbp(GO:autophagy)p(HGNC:MAPT, pmod(Ph))path(HBP:Neurodegeneration)
Jensa(HBP:"Tau oligomers")a(HBP:"Tau oligomers")path(MESH:"Supranuclear Palsy, Progressive")
Jensa(CHEBI:wortmannin)p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356))p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356))
Jensbp(GO:"MAPK cascade")p(HGNC:AGER)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta polypeptide 42")a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")a(MESH:Microglia)
Jensa(CHEBI:"methylene blue")bp(GO:autophagy)p(HGNC:MAPT, pmod(Ph))
Jensp(HGNC:MAPK1)p(HGNC:MAPT, pmod(Ph, Ser, 202))path(MESH:"Alzheimer Disease")
Jensa(HBP:"Tau aggregates")bp(GO:"axonal transport")path(HBP:Neurodegeneration)
Jensbp(GO:autophagy)p(HGNC:MTOR)path(MESH:"Neurodegenerative Diseases")
Jensa(HBP:"Tau aggregates")bp(MESH:Autophagy)p(HBP:"Tau C3")
Jensa(CHEBI:"alpha,alpha-trehalose")a(HBP:"alpha-synuclein aggregates")bp(GO:autophagy)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"reactive oxygen species")complex(GO:"NF-kappaB complex")
Jensa(CHEBI:"amyloid-beta")p(FPLX:ERK)path(MESH:"Alzheimer Disease")
Jensbp(GO:"neuron apoptotic process")p(HGNC:PRKN)path(MESH:"Alzheimer Disease")
Jensa(HBP:"Tau aggregates")p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))p(HGNC:SYK)
Jensbp(MESH:"Oxidative Stress")p(HGNC:MAPT)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")bp(GO:endocytosis)bp(GO:memory)
Jensa(CHEBI:sirolimus)bp(GO:autophagy)p(HGNC:HTT)
Jensa(HBP:"Tau aggregates")p(HGNC:MAPT)p(HGNC:SYK)
Jensp(HGNC:CDC37)p(HGNC:CDK5)p(HGNC:MAPT, pmod(Ph, Ser, 202))
Jensa(PUBCHEM:164676)p(FPLX:IKB)p(FPLX:NFkappaB)
Jensp(HGNC:CHRNA7)p(HGNC:CHRNA7)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")bp(GO:"canonical Wnt signaling pathway")composite(p(HGNC:APP), p(HGNC:VANGL2))
Jensm(MIRBASE:"hsa-mir-155")p(FPLX:NFkappaB)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:nicotine)p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
Jensa(HBP:"Tau aggregates")complex(GO:"proteasome complex")path(HBP:Neurodegeneration)
Jensp(HGNC:CDK5)p(HGNC:IL18)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")a(HBP:HBP00038)bp(GO:phagocytosis)
Jensa(CHEBI:galanthamine)bp(GO:"synaptic transmission, cholinergic")path(MESH:Schizophrenia)
Jensa(CHEBI:donepezil)p(HGNC:ABCB1)path(MESH:"Alzheimer Disease")
Jensp(HGNC:MAPT)p(HGNC:MAPT)p(HGNC:PIN1, pmod(Ph, Ser, 71))
Jensa(CHEBI:"amyloid-beta")a(CHEBI:Anatabine)path(MESH:"Interpersonal Relations")
Jensa(CHEBI:nicotine)bp(GO:"MAPK cascade")p(HBP:"alpha-4 beta-2 nAChR")
Jensa(CHEBI:acetylcholine)bp(GO:"synaptic transmission, cholinergic")bp(GO:memory)
Jensbp(MESH:"Endoplasmic Reticulum Stress")complex(p(HGNC:ATF6), p(MESH:"molecular chaperone GRP78"))p(HGNC:ATF6)
Jensp(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212))p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212))p(HBP:HBP00053, pmod(Ph, Ser, 214), pmod(Ph, Thr, 212))
Jensa(HBP:"Tau oligomers")p(HGNC:MAPT)p(HGNC:MAPT, var("p.Ala152Thr"))
Jensa(GO:autolysosome)bp(GO:"lysosomal protein catabolic process")path(MESH:"Alzheimer Disease")
Jensa(HBP:"amyloid-beta oligomers")p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Jensp(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))path(MESH:Schizophrenia)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:oleocanthal)p(HGNC:ABCB1)
Jensa(HBP:"Tau aggregates")complex(a(GO:microtubule), p(HGNC:MAPT))path(MESH:"Alzheimer Disease")
Jensp(FPLX:ERK)p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
Jensa(HBP:"alpha-synuclein aggregates")p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins")path(MESH:"Alzheimer Disease")
Jensbp(GO:"long-term synaptic potentiation")complex(complex(GO:"filamentous actin"), p(HGNC:MAPT))p(HGNC:MAPT)
Jensp(HGNC:MAPT)p(HGNC:MAPT)path(MESH:"Frontotemporal Dementia")
Jenscomplex(GO:"proteasome complex")p(HGNC:PRKN)p(HGNC:SNCA)
Jenscomplex(p(HGNC:FYN), p(HGNC:MAPT))p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")p(FPLX:NFkappaB)p(HGNC:BACE1)
Jensa(HBP:"Tau aggregates")complex(a(GO:microtubule), p(HGNC:MAPT))p(HGNC:MAPT, var("?"))
Jensa(CHEBI:"amyloid-beta")complex(GO:"NF-kappaB complex")p(HGNC:BACE1)
Jenscomplex(GO:"NF-kappaB complex")p(HGNC:SIRT1)path(MESH:"Alzheimer Disease")
Jensa(HBP:"Tau aggregates")a(HBP:"Tau aggregates")path(MESH:"Alzheimer Disease")
Jensp(HGNC:NGFR)path(MESH:"Alzheimer Disease")path(MESH:"Cognitive Dysfunction")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(FPLX:TLR)
Jensp(HGNC:MAPT)p(HGNC:MAPT)path(MESH:"Pick Disease of the Brain")
Jensa(CHEBI:"amyloid-beta polypeptide 42")p(FPLX:AMPK)p(HGNC:MAPT, pmod(Ph, Ser, 396))
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:CHRNA7)
Jensp(HGNC:CDC37)p(HGNC:CDK5)p(HGNC:MAPT, pmod(Ph, Ser, 396))
Jensa(CHEBI:"lithium(1+)")bp(GO:autophagy)p(HGNC:SNCA)
Jensa(CHEBI:"amyloid-beta")complex(GO:"inflammasome complex")p(HGNC:IL18)
Jensa(HBP:"Tau aggregates")a(HBP:"Tau aggregates")p(HGNC:SYK)
Jensa(MESH:"Neurofibrillary Tangles")p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))path(MESH:"Alzheimer Disease")
Jensp(FPLX:AKT)p(HGNC:DRD1)path(MESH:Schizophrenia)
Jensp(HGNC:MAPT)p(HGNC:MAPT, pmod(Ph))p(HGNC:MAPT, pmod(Ub))
Jensp(HGNC:CDK2)p(HGNC:MAPT, pmod(Ph, Ser, 202))path(MESH:"Alzheimer Disease")
Jenscomplex(GO:"inflammasome complex")p(HGNC:CASP1)p(HGNC:IL18)
Jensp(HGNC:CDK5)p(HGNC:MAPT, pmod(Ph, Ser, 202))path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"methylene blue")a(HBP:"Tau oligomers")bp(GO:cognition)
Jensp(HGNC:AK1)p(HGNC:MAPT)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:Nilvadipine)p(HGNC:MAPT, pmod(Ph, Ser, 404))
Jensa(CHEBI:"amyloid-beta")a(MESH:"Lymphatic Vessels")bp(GO:aging)
Jensa(HBP:"amyloid-beta derived diffusible ligands")a(HBP:"amyloid-beta derived diffusible ligands")a(HBP:"amyloid-beta derived diffusible ligands")
Jensa(CHEBI:"amyloid-beta polypeptide 42")a(MESH:Microglia)complex(GO:"NF-kappaB complex")
Jensp(HGNC:MAPT, pmod(Ac, Lys, 353))p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")p(HGNC:APP)p(HGNC:BACE1)
Jensa(CHEBI:"amyloid-beta")p(HGNC:AGER)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"reactive oxygen species")p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta polypeptide 42")bp(GO:endocytosis)g(HBP:"APOE e4")
Jensa(CHEBI:rolipram)complex(GO:"proteasome complex")p(HGNC:MAPT)
Jensbp(GO:"apoptotic process")p(FPLX:AKT)p(HGNC:RELA)
Jenscomplex(GO:"NF-kappaB complex")p(HGNC:IL1B)path(MESH:"Alzheimer Disease")
Jensa(GO:"neurofibrillary tangle")p(ECCODE:"2.3.2.13")path(MESH:"Supranuclear Palsy, Progressive")
Jensa(CHEBI:sirolimus)bp(GO:autophagy)p(FPLX:mTORC1)
Jensa(CHEBI:"amyloid-beta")complex(GO:"NLRP1 inflammasome complex")p(HGNC:IL1B)
Jensp(HGNC:HSPB1)p(HGNC:MAPT)p(HGNC:MAPT)
Jensp(HGNC:CDK5)p(HGNC:DRD1)path(MESH:Schizophrenia)
Jensa(CHEBI:"lithium(1+)")bp(GO:autophagy)p(HGNC:MTOR)
Jensa(CHEBI:"amyloid-beta")complex(GO:"NF-kappaB complex")p(HGNC:BCL2)
Jensp(HGNC:MAPT, pmod(Ac, Lys, 280))p(HGNC:MAPT, pmod(Ac, Lys, 280))path(MESH:"Niemann-Pick Diseases")
Jensa(CHEBI:"amyloid-beta")bp(GO:endocytosis)g(HBP:"APOE e4")
Jensa(CHEBI:"amyloid-beta")p(HGNC:MAPT)p(HGNC:SYK)
Jensa(CHEBI:"amyloid-beta")p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
Jenspath(MESH:"Alzheimer Disease")r(HGNC:"BACE1-AS")r(HGNC:BACE1)
Jensa(CHEBI:sirolimus)p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Jensa(CHEBI:"amyloid-beta")path(MESH:"Alzheimer Disease")path(MESH:Anxiety)
Jensa(HBP:"Tau aggregates")bp(GO:macroautophagy)p(MGI:Mapt)
Jensa(CHEBI:palbociclib)a(HBP:"Tau isoform F (441 aa)")p(HGNC:CDK4)
Jensa(HBP:"Tau aggregates")a(HBP:"Tau oligomers")bp(MESH:Autophagy)
Jenscomplex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1))p(HGNC:PPP2CA, pmod(Me, Leu, 309))p(HGNC:PTPA)
Jensa(HBP:"Tau aggregates")p(HGNC:PPID)path(MESH:"Alzheimer Disease")
Jensbp(GO:"neuron death")p(HGNC:MAPT)path(MESH:Tauopathies)
Jensp(HGNC:MAPT)p(HGNC:MAPT)path(MESH:Tauopathies)
Jensa(HBP:"Tau aggregates")complex(GO:"proteasome complex")p(HGNC:MAPT, var("?"))
Jensp(HGNC:MAPT, pmod(HBP:hyperphosphorylation))path(MESH:"Alzheimer Disease")path(MESH:Inflammation)
Jensa(MESH:"Neurofibrillary Tangles")p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Jensbp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")p(HGNC:BAG1)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta polypeptide 40")a(CHEBI:nicotine)a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")
Jensa(CHEBI:nilotinib)bp(GO:macroautophagy)p(HGNC:ABL1)
Jenscomplex(GO:"proteasome complex")p(HGNC:MAPT)p(HGNC:SQSTM1)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"calcium(2+)")p(HGNC:CHRNA7)
Jensa(GO:"neurofibrillary tangle")p(HGNC:CDKN2A)path(MESH:"Supranuclear Palsy, Progressive")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:nicotine)path(HBP:neurotoxicity)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:acetylcholine)p(FPLX:CHRM)
Jensbp(MESH:"Oxidative Stress")p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))path(MESH:"Alzheimer Disease")
Jensa(GO:lysosome)a(HBP:"Tau aggregates")path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"okadaic acid")p(FPLX:PPP2)p(HGNC:MAPT, pmod(Ph))
Jensp(FPLX:GSK3)p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
Jensp(HGNC:MAPT, pmod(HBP:nitration, Tyr, 18))path(MESH:"Alzheimer Disease")path(MESH:"Plaque, Amyloid")
Jensbp(HBP:"protein aggregation")complex(a(GO:"proteasome complex"), p(HGNC:BAG6))p(MESH:Proteins, pmod(HBP:misfolding))
Jensa(MESH:Microglia)complex(GO:"NF-kappaB complex")p(HGNC:TNF)
Jensa(CHEBI:Thrombin)p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
Jensa(CHEBI:galanthamine)bp(GO:"synaptic transmission, cholinergic")path(MESH:"Alzheimer Disease")
Jenscomplex(p(HGNC:FYN), p(HGNC:MAPT))p(HGNC:MAPT, pmod(Ph, Ser, 202))path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:wogonin)bp(GO:autophagy)
Jensp(HGNC:MAPT, pmod(Ac, Lys, 280))p(HGNC:MAPT, pmod(Ac, Lys, 280))path(MESH:"Alzheimer Disease")
Jensp(FPLX:GSK3)p(HGNC:MAPT, pmod(Ph, Ser, 202))path(MESH:"Alzheimer Disease")
Jenscomplex(GO:"NF-kappaB complex")p(HGNC:IL6)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")a(PUBCHEM:53340666)bp(GO:autophagy)
Jensa(CHEBI:dorsomorphin)p(FPLX:AMPK)p(HGNC:MAPT, pmod(Ph, Ser, 404))
Jensp(HGNC:MAPT, pmod(Ph, Thr, 205))p(HGNC:MAPT, var("p.Pro301Ser"))p(HGNC:MAPT, var("p.Pro301Ser"))
Jensp(HBP:"N-terminal fragment of ATF6")p(HBP:"N-terminal fragment of ATF6")p(HBP:"N-terminal fragment of ATF6")
Jensa(HBP:"alpha-synuclein aggregates")bp(GO:"neuron death")path(MESH:"Parkinson Disease")
Jensp(FPLX:ERK)p(HGNC:MAPT, pmod(Ph, Ser, 404))path(MESH:"Alzheimer Disease")
Jensp(MGI:"interleukin 1 alpha")p(MGI:"oncostatin M")p(MGI:"signal transducer and activator of transcription 3")
Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:nicotine)p(FPLX:CHRN)
Jensbp(GO:locomotion)p(HGNC:MAPT)p(HGNC:MAPT, var("p.Lys280del"))
Jensa(MESH:antalarmin)path(HBP:"isolation rearing")r(RGD:Ntrk2)
Jensa(CHEBI:"alpha,alpha-trehalose")bp(GO:"neuron apoptotic process")bp(GO:cognition)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:Anatabine)path(MESH:Anxiety)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:clozapine)bp(GO:autophagy)
Jensa(CHEBI:"amyloid-beta")bp(GO:"long-term synaptic potentiation")p(HGNC:NFKB1)
Jensbp(GO:macroautophagy)p(FPLX:mTORC1)p(HGNC:TFEB)
Jensbp(GO:"microglial cell activation")p(HGNC:IL6)path(MESH:"Alzheimer Disease")
Jensa(GO:"neurofibrillary tangle")a(HBP:"Tau aggregates")p(MGI:Mapt)
Jenscomplex(GO:"neuron projection")p(HGNC:MAPT)p(HGNC:MAPT)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:acetylcholine)bp(GO:memory)
Jensa(CHEBI:chlorpromazine)bp(GO:autophagy)p(HGNC:MTOR)
Jensp(HGNC:CDK5)p(HGNC:MAPT, pmod(Ph, Thr, 181))path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")bp(GO:memory)path(MESH:"Alzheimer Disease")
Jensa(HBP:"Tau oligomers")a(HBP:"Tau oligomers")path(MESH:"Alzheimer Disease")
Jensa(HBP:"Tau aggregates")bp(MESH:Autophagy)p(HGNC:MAPT)
Jensa(CHEBI:"amyloid-beta")p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")p(HGNC:BACE1)p(HGNC:RELA)
Jensa(CHEBI:"amyloid-beta")p(FPLX:NFkappaB)p(HGNC:IL1B)
Jensp(HGNC:MAPT)p(HGNC:MAPT, pmod(Ub))path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"calcium(2+)")a(CHEBI:dopamine)a(HBP:HBP00093)
Jensa(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor")bp(GO:cognition)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:MMP2)
Jenscomplex(GO:"proteasome complex")p(HGNC:MAPT, pmod(Ph))path(HBP:Neurodegeneration)
Jensa(CHEBI:"amyloid-beta")bp(GO:"cell death")p(FPLX:HSPA)
Jensp(HGNC:MAPT)p(HGNC:MAPT, pmod(Ac, Lys, 280))path(HBP:Neurodegeneration)
Jensa(HBP:HBP00074)p(HGNC:NGFR)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:methamphetamine)bp(GO:autophagy)p(HGNC:MTOR)
Jensbp(GO:"microglial cell activation")p(HGNC:IL18)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")p(HGNC:IL6)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")bp(GO:autophagy)p(HGNC:BIN1)
Jensa(HBP:"amyloid-beta aggregates")path(MESH:"Alzheimer Disease")path(MESH:"Plaque, Amyloid")
Jensp(HGNC:MAPT, pmod(Ac, Lys, 163))p(HGNC:MAPT, pmod(Ac, Lys, 163))p(HGNC:MAPT, pmod(Ac, Lys, 163))
Jensa(HBP:"Tau aggregates")p(HGNC:AHSA1)path(MESH:"Alzheimer Disease")
Jensa(HBP:"Tau aggregates")complex(GO:"proteasome complex")p(FPLX:PKA)
Jensa(CHEBI:sirolimus)bp(GO:behavior)path(MESH:"Huntington Disease")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")a(MESH:Astrocytes)
Jensa(GO:autophagosome)a(GO:lysosome)path(MESH:"Alzheimer Disease")
Jensp(HBP:"UBB+1", pmod(UbPoly))p(HBP:"UBB+1", pmod(UbPoly))p(HBP:"UBB+1", pmod(UbPoly))
Jensa(CHEBI:cholesterol)bp(GO:endocytosis)p(HBP:"APP C-terminally truncated carboxyl-terminal fragments")
Jensa(MESH:Proteins)a(MESH:Proteins)a(MESH:Proteins)
Jensa(HBP:HBP00089)bp(GO:"microglial cell activation")p(HGNC:CCL2)
Jensbp(GO:autophagy)p(HGNC:CAPN2)p(HGNC:CAST)
Jensa(HBP:"alpha-synuclein aggregates")bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")p(HGNC:IDE)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:water)path(MESH:"Alzheimer Disease")
Jensa(HBP:"Tau aggregates")bp(MESH:Autophagy)path(MESH:"Alzheimer Disease")
Jensa(HBP:"Tau oligomers")a(HBP:"Tau oligomers")p(HGNC:MAPT)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:acetylcholine)a(CHEBI:acetylcholine)
Jensa(CHEBI:donepezil)p(FPLX:CHRN)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor")bp(GO:"synaptic transmission, cholinergic")path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:"amyloid-beta")bp(GO:phagocytosis)
Jensp(HGNC:PTGS2)path(MESH:"Alzheimer Disease")path(MESH:Inflammation)
Jensbp(GO:"apoptotic process")bp(MESH:"Oxidative Stress")p(HGNC:GSK3B)
Jensa(CHEBI:"amyloid-beta polypeptide 42")a(MESH:Microglia)bp(GO:phagocytosis)
Jensa(CHEBI:"amyloid-beta")bp(GO:memory)p(HGNC:BACE1)
Jensa(CHEBI:"Hsp90 inhibitor")p(HGNC:MAPT)p(HGNC:MAPT)
Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:Anatabine)p(HGNC:CHRNA7)
Jensbp(MESH:Aging)p(FPLX:HSP90)path(MESH:"Protein Aggregation, Pathological")
Jensbp(GO:autophagy)p(HGNC:HSPB1)p(HGNC:MAPT)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:donepezil)p(HGNC:CHRNA7)
Jensbp(GO:memory)p(HGNC:BACE1)p(HGNC:UCHL1)
Jensa(CHEBI:"all-trans-retinoic acid")a(CHEBI:"amyloid-beta")bp(GO:memory)
Jensa(CHEBI:"lithium atom")bp(GO:autophagy)p(HGNC:MAPT)
Jensa(CHEBI:ambroxol)bp(GO:macroautophagy)p(HGNC:SNCA)
Jensbp(GO:autophagy)p(HGNC:MAPT)p(HGNC:NPEPPS)
Jensa(CHEBI:"amyloid-beta")a(MESH:"Cholinesterase Inhibitors")path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:sirolimus)bp(GO:autophagy)
Jensa(CHEBI:lactacystin)p(HGNC:MAPT)p(HGNC:MAPT)
Jensa(MESH:Proteins)a(MESH:Proteins)p(HGNC:RAB5A)
Jensa(CHEBI:"amyloid-beta")bp(GO:"MAPK cascade")path(MESH:"Alzheimer Disease")
Jensbp(MESH:Aging)p(FPLX:HSPA)path(MESH:"Protein Aggregation, Pathological")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:IDE)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")a(MESH:Liver)
Jenscomplex(a(GO:microtubule), p(HGNC:MAPT))p(HGNC:MAPT)p(HGNC:MAPT, var("p.Lys280del"))
Jensp(HGNC:MAPT)p(HGNC:MAPT, frag("?"))path(HBP:Neurodegeneration)
Jensa(CHEBI:"amyloid-beta")a(MESH:Astrocytes)p(HGNC:IL1B)
Jensa(GO:"late endosome")p(MGI:Mapt)p(MGI:Mapt, var("p.Ala152Thr"))
Jensa(CHEBI:methamphetamine)a(CHEBI:sirolimus)bp(GO:autophagy)
Jensa(PUBCHEM:675434)p(FPLX:Proteasome)p(HGNC:MAPT)
Jensp(HGNC:FKBP5)p(HGNC:MAPT)path(MESH:"Alzheimer Disease")
Jensbp(MESH:Aging)p(FPLX:HSP90)p(HGNC:PTGES3)
Jensa(HBP:"Tau fibrils")p(MGI:Tfeb)p(MGI:Tfeb)
Jensp(FPLX:GSK3)p(HGNC:MAPT, pmod(Ph, Ser, 404))path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")p(HGNC:BIN1)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide")a(CHEBI:"amyloid-beta polypeptide 42")complex(GO:"NF-kappaB complex")
Jensbp(GO:"mitochondrion transport along microtubule")composite(p(HBP:"4R tau", var("p.Lys280del")), p(HGNC:STUB1))p(HBP:"4R tau", var("p.Lys280del"))
Jensa(CHEBI:Calpeptin)p(HGNC:CAPN2)p(HGNC:HTT, var("?"))
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:MMP3)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:nicotine)path(MESH:"Plaque, Amyloid")
Jensa(CHEBI:"okadaic acid")p(HGNC:MAPT, pmod(Ph))p(HGNC:PPP2CA)
Jensa(HBP:"Tau aggregates")p(HGNC:MAPT, pmod(Ph, Thr, 231))path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta polypeptide 40")a(CHEBI:nicotine)a(HBP:"alpha-4 beta-2 nAChR")
Jensp(HBP:"cis p-tau")p(HGNC:PIN1)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:Nilvadipine)r(HGNC:BACE1)
Jensa(GO:"neurofibrillary tangle")a(HBP:"Tau oligomers")p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))
Jensa(CHEBI:sirolimus)bp(GO:macroautophagy)p(HGNC:MAPT, pmod(Ph))
Jensp(HGNC:HMOX1)p(HGNC:NFE2L2)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")complex(p(HGNC:MAPT), p(INTERPRO:"Triosephosphate isomerase", pmod(NO)))
Jensbp(GO:autophagy)p(HGNC:CAPN1)p(HGNC:CAST)
Jensa(CHEBI:Temsirolimus)bp(GO:autophagy)p(HGNC:MAPT, pmod(Ph))
Jensa(CHEBI:"amyloid-beta")a(CHEBI:nicotine)p(HGNC:TNF)
Jensa(CHEBI:Anatabine)a(GO:"myelin sheath")path(MESH:Encephalomyelitis)
Jensa(CHEBI:"amyloid-beta")p(FPLX:Proteasome)path(HBP:neurotoxicity)
Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:"amyloid-beta")p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
Jensbp(GO:endocytosis)p(HBP:"APP C-terminally truncated carboxyl-terminal fragments")p(HGNC:RAB5A)
Jensa(CHEBI:"amyloid-beta")path(MESH:"Alzheimer Disease")r(HGNC:"BACE1-AS")
Jenscomplex(a(GO:"proteasome complex"), p(HGNC:PRKN))p(HGNC:PRKN, var("p.Arg42"))path(MESH:"Parkinsonian Disorders")
Jensa(CHEBI:rolipram)p(FPLX:Proteasome)p(HGNC:MAPT)
Jensbp(GO:autophagy)p(FPLX:HSP90)p(HGNC:MAPT, pmod(Ph))
Jensa(CHEBI:galanthamine)bp(GO:learning)p(MGI:App, frag("25_35"))
Jensa(CHEBI:"amyloid-beta")a(CHEBI:acetylcholine)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta polypeptide 42")bp(MESH:Neuroprotection)complex(GO:"NF-kappaB complex")
Jensa(CHEBI:"amyloid-beta")p(HGNC:CASP1)p(HGNC:IL1B)
Jensbp(GO:"MAPK cascade")p(HGNC:BACE1)path(MESH:"Alzheimer Disease")
Jensbp(GO:memory)complex(GO:"NF-kappaB complex")p(HGNC:BACE1)
Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:nicotine)p(HBP:"alpha-4 beta-2 nAChR")
Jensa(CHEBI:"amyloid-beta")a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")bp(GO:"apoptotic process")
Jensbp(GO:memory)complex(GO:"NF-kappaB complex")path(MESH:"Alzheimer Disease")
Jensa(CHEBI:dopamine)p(HGNC:DISC1, var("?"))path(MESH:Schizophrenia)
Jensa(CHEBI:"amyloid-beta")p(HGNC:CASP1)p(HGNC:IL18)
Jensa(CHEBI:"potassium(1+)")complex(GO:"NLRP1 inflammasome complex")p(HGNC:IL1B)
Jensa(CHEBI:bortezomib)p(FPLX:PPP2C)p(HGNC:CIP2A)
Jensp(FPLX:ERK)p(HGNC:TNF)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"calcium(2+)")a(CHEBI:acetylcholine)a(CHEBI:choline)
Jensp(MGI:Mapt)p(MGI:Mapt, var("p.Ala152Thr"))p(MGI:Mapt, var("p.Ala152Thr"))
Jensa(CHEBI:Thrombin)p(HGNC:MAPT)path(MESH:"Alzheimer Disease")
Jensp(FPLX:ERK)p(HGNC:MAPT, pmod(Ph, Ser, 199))path(MESH:"Alzheimer Disease")
Jensp(HBP:"Tau epitope, PHF1")p(HGNC:GSK3B)p(HGNC:MAPT, pmod(Ph, Ser, 396))
Jenscomplex(GO:"protein phosphatase type 2A complex")p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
Jensp(HGNC:MAPT, pmod(HBP:hyperphosphorylation))p(HGNC:MAPT, pmod(OGlyco))path(MESH:"Alzheimer Disease")
Jensa(CHEBI:donepezil)p(HGNC:CHRNA4)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"methylene blue")bp(GO:macroautophagy)p(HGNC:MAPT, pmod(Ph))
Jensa(CHEBI:"amyloid-beta")bp(GO:aging)bp(GO:memory)
Jensp(HGNC:MAPT, var("p.Pro301Ser"))p(HGNC:MAPT, var("p.Pro301Ser"))p(HGNC:MAPT, var("p.Pro301Ser"))
Jensp(HGNC:GSK3B)p(HGNC:GSK3B, pmod(Ph, Ser, 9))p(HGNC:SYK)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:APOE)
Jensa(CHEBI:"okadaic acid")bp(GO:cognition)path(HBP:Neurodegeneration)
Jensa(CHEBI:sirolimus)bp(GO:autophagy)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")complex(GO:"NF-kappaB complex")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:MMP9)
Jensp(FPLX:NFkappaB)path(MESH:"Alzheimer Disease")r(HGNC:BACE1)
Jensa(CHEBI:"amyloid-beta")a(MESH:"Lymphatic Vessels")bp(GO:memory)
Jensp(FPLX:GSK3)p(HGNC:MAPT, pmod(Ph, Ser, 396))path(MESH:"Alzheimer Disease")
Jenscomplex(GO:"inflammasome complex")p(HGNC:CASP1)p(HGNC:IL1B)
Jensp(MGI:Mapt, var("p.Pro301Leu"))p(MGI:Mapt, var("p.Pro301Leu"))p(MGI:Mapt, var("p.Pro301Leu"))
Jensbp(GO:"MAPK cascade")p(FPLX:NFkappaB)path(MESH:"Alzheimer Disease")
Jensa(PUBCHEM:49850262)bp(GO:autophagy)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Jensa(CHEBI:"amyloid-beta")bp(GO:endocytosis)p(HGNC:RAB5A)
Jensa(CHEBI:methamphetamine)bp(GO:"response to oxidative stress")bp(GO:autophagy)
Jensa(CHEBI:sirolimus)bp(GO:autophagy)p(HGNC:MTOR)
Jensbp(GO:"clathrin-dependent endocytosis")p(HGNC:MAPT)p(HGNC:MAPT)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:SYK)
Jensp(MGI:Rela, pmod(Ph))p(MGI:Stat3, pmod(Ph))path(MESH:Encephalomyelitis)
Jensa(CHEBI:nicotine)a(HBP:"Tau aggregates")path(HBP:neurotoxicity)
Jensa(GO:"neurofibrillary tangle")complex(GO:"NF-kappaB complex")p(HGNC:TNF)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:nicotine)p(HGNC:CHRNA4)
Jensp(FPLX:PPP2)p(HGNC:MAPT, pmod(Ph, Ser, 202), pmod(Ph, Thr, 205))path(MESH:"Alzheimer Disease")
Jensa(HBP:"Tau isoform F (441 aa)")a(HBP:"Tau isoform F (441 aa)")a(HBP:"phosphatase-activating domain")
Jensp(HGNC:MAPT, pmod(Ac, Lys, 174))p(HGNC:SIRT1)path(MESH:"Alzheimer Disease")
Jensbp(MESH:"Oxidative Stress")path(MESH:"Alzheimer Disease")path(MESH:Aging)
Jensa(CHEBI:"reactive oxygen species")p(FPLX:ERK)path(MESH:"Alzheimer Disease")
Jensbp(GO:autophagy)complex(GO:"CHOP-C/EBP complex")p(HGNC:BCL2)
Jensa(CHEBI:"amyloid-beta")a(PUBCHEM:16057918)p(HGNC:BCL2L1)
Jensa(HBP:"dystrophic neurite")bp(GO:aging)path(MESH:"Alzheimer Disease")
Jensa(MESH:Proteins)bp(GO:endocytosis)p(HGNC:RAB5A)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:tanespimycin)bp(GO:memory)
Jensa(HBP:"Tau oligomers")a(HBP:"Tau oligomers")path(HBP:neurotoxicity)
Jensa(CHEBI:dopamine)a(CHEBI:nicotine)p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
Jensp(HGNC:CHRNA4)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))path(MESH:"Alzheimer Disease")
Jensbp(GO:"lysosomal protein catabolic process")bp(GO:autophagy)p(MESH:Proteins, pmod(HBP:misfolded))
Jensbp(GO:autophagy)bp(MESH:"Endoplasmic Reticulum Stress")p(HGNC:BCL2)
Jensa(CHEBI:"amyloid-beta")bp(GO:"neuron apoptotic process")p(HGNC:RELA)
Jensa(CHEBI:"reactive oxygen species")complex(GO:"NF-kappaB complex")path(MESH:"Alzheimer Disease")
Jensa(CHEBI:nicotine)a(MESH:"SNARE Proteins")p(HGNC:CHRNA7)
Jensa(CHEBI:"calcium(2+)")a(CHEBI:acetylcholine)a(MESH:"Receptors, Nicotinic")
Jensa(MESH:Microglia)bp(GO:"neuron death")complex(GO:"NF-kappaB complex")
Jensp(HGNC:MAPT, pmod(Ph))p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")path(MESH:"Alzheimer Disease")
Jensm(MIRBASE:"hsa-mir-125b-1")p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))p(HGNC:PPP1CA)
Jensa(CHEBI:"amyloid-beta")p(HGNC:MAPT)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")bp(GO:macroautophagy)p(HGNC:IDE)
Jensa(CHEBI:"amyloid-beta")bp(GO:memory)p(HGNC:CHRNA7)
Jensa(CHEBI:"amyloid-beta")p(HBP:"APOE e4")path(MESH:"Alzheimer Disease")
Jenscomplex(GO:"protein phosphatase type 2A complex")p(HGNC:GSK3B)p(HGNC:MAPT, pmod(Ph))
Jensbp(GO:endocytosis)p(HBP:"APP C-terminally truncated carboxyl-terminal fragments")p(HGNC:APP)
Jensa(HBP:"Tau aggregates")complex(a(GO:microtubule), p(HGNC:MAPT))p(HGNC:MAPT, pmod(Ph))
Jensa(CHEBI:"calcium(2+)")a(CHEBI:acetylcholine)p(FPLX:CHRN)
Jensa(HBP:"Tau oligomers")a(MESH:Neurons)p(HGNC:MAPT)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))
Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:"amyloid-beta")complex(GO:"NLRP1 inflammasome complex")
Jensa(CHEBI:sirolimus)bp(GO:autophagy)p(HGNC:SNCA)
Jensa(CHEBI:"amyloid-beta")p(HGNC:ABCB1)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide")p(HGNC:GSK3B, pmod(Ph, Ser, 9))p(HGNC:SYK)
Jensp(FPLX:PPP2)p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
Jensa(HBP:"Tau aggregates")p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
Jenscomplex(GO:"proteasome complex")p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))path(HBP:Neurodegeneration)
Jensp(HGNC:CDK2)p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:nicotine)bp(GO:memory)
Jensa(CHEBI:"amyloid-beta")a(MESH:Astrocytes)path(MESH:"Plaque, Amyloid")
Jensa(CHEBI:sirolimus)bp(GO:macroautophagy)p(FPLX:mTORC1)
Jensa(HBP:"Tau aggregates")a(HBP:"Tau aggregates")p(HGNC:MAPT, pmod(Ph))
Jensbp(GO:"neuron death")p(HGNC:RAB5A)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HBP:"APOE e4")
Jensa(CHEBI:sirolimus)bp(GO:"motor behavior")path(MESH:"Huntington Disease")
Jensbp(GO:macroautophagy)p(HGNC:MAPT, pmod(Ph))p(HGNC:MAPT, var("p.Ala152Thr"))
Jensa(MESH:Hippocampus)p(HGNC:CHRNA7)path(MESH:Schizophrenia)
Jensa(HBP:"Tau aggregates")p(HGNC:OGT)path(MESH:"Alzheimer Disease")
Jensa(GO:"neurofibrillary tangle")a(HBP:"Tau oligomers")path(MESH:"Supranuclear Palsy, Progressive")
Jensp(HGNC:CAPN1)p(HGNC:CAST)p(HGNC:HTT, var("?"))
Jensa(CHEBI:nicotine)bp(GO:"ERK1 and ERK2 cascade")bp(GO:"apoptotic process")
Jensp(HGNC:MAPT)p(HGNC:MAPT)p(HGNC:NPEPPS)
Jensa(CHEBI:scopolamine)a(MESH:VU0357017)bp(GO:"behavioral fear response")
Jensa(CHEBI:"amyloid-beta")a(MESH:Microglia)p(HGNC:IL1B)
Jensa(CHEBI:"amyloid-beta")p(HGNC:IL1B)path(MESH:"Alzheimer Disease")
Jensbp(GO:"microtubule polymerization")p(HGNC:DAPK1)p(HGNC:MAPT)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")path(MESH:"Diabetes Mellitus")
Jensa(HBP:"Tau oligomers")bp(GO:"long-term synaptic potentiation")p(HGNC:MAPT)
Jensa(CHEBI:nicotine)a(MESH:"Dopaminergic Neurons")p(HBP:"alpha-4 beta-2 nAChR")
Jensa(HBP:"Tau aggregates")a(HBP:"Tau aggregates")a(HBP:"Tau aggregates")
Jensa(CHEBI:"amyloid-beta")bp(GO:memory)g(HGNC:NLRP3)
Jensa(MESH:Neurons)p(HGNC:MAPT)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide")a(CHEBI:"amyloid-beta")complex(GO:"NF-kappaB complex")
Jensa(CHEBI:Temsirolimus)a(HBP:"alpha-synuclein aggregates")bp(GO:autophagy)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")a(CHEBI:nicotine)
Jensa(CHEBI:sirolimus)bp(GO:cognition)path(MESH:"Alzheimer Disease")
Jensp(HGNC:HSF1)p(HGNC:HSF1)p(HGNC:HSF1)
Jensa(CHEBI:"amyloid-beta")bp(GO:endocytosis)p(HGNC:BIN1)
Jensa(CHEBI:"amyloid-beta")bp(GO:"innate immune response")complex(GO:"NLRP3 inflammasome complex")
Jensa(GO:"neurofibrillary tangle")a(HBP:"Tau aggregates")p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))
Jensa(CHEBI:"amyloid-beta")bp(GO:"long-term synaptic potentiation")p(HGNC:CHRM1)
Jensa(GO:autophagosome)a(MESH:Proteins)bp(GO:autophagy)
Jensa(CHEBI:sirolimus)p(HGNC:MTOR)p(HGNC:SNCA)
Jensa(GO:"neurofibrillary tangle")bp(GO:"apoptotic process")p(HGNC:NFKB1)
Jensa(CHEBI:"methylene blue")p(HGNC:MAPT)p(HGNC:SQSTM1)
Jensa(CHEBI:rivastigmine)p(FPLX:CHRN)path(MESH:"Alzheimer Disease")
Jensbp(MESH:"Oxidative Stress")p(HGNC:GSK3B)p(HGNC:MAPT)
Jensa(HBP:"Tau aggregates")p(HGNC:MAPT, pmod(Ph))path(HBP:Neurodegeneration)
Jensa(HBP:"alpha-synuclein aggregates")p(HGNC:IDE)path(MESH:"Alzheimer Disease")
Jensp(HBP:"phosphatase-activating domain")p(HGNC:MAPT, pmod(Ph, Thr, 205))path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")bp(GO:"lysosomal protein catabolic process")bp(GO:memory)
Jensa(MESH:"Cholinergic Neurons")path(MESH:"Alzheimer Disease")path(MESH:Apathy)
Jensa(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor")bp(GO:"synaptic transmission, cholinergic")p(HGNC:ACHE)
Jensp(HGNC:MAPT, pmod(Ac, Lys, 259))p(HGNC:MAPT, pmod(Ac, Lys, 259))p(HGNC:MAPT, pmod(Ac, Lys, 259))
Jensa(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide")a(CHEBI:"amyloid-beta polypeptide 42")p(HGNC:MAPT, pmod(Ph, Ser, 202))
Jensa(CHEBI:"amyloid-beta")bp(GO:macroautophagy)p(HGNC:TFEB)
Jenscomplex(a(GO:microtubule), p(HGNC:MAPT))p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Jensa(GO:"neurofibrillary tangle")a(HBP:"Tau fibrils")p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))
Jensp(HGNC:FYN)p(HGNC:MAPT, pmod(Ph, Tyr, 18))path(MESH:"Alzheimer Disease")
Jensp(HBP:"phosphatase-activating domain")p(HGNC:GSK3B)p(HGNC:MAPT, pmod(Ph, Ser, 422))
Jensa(HBP:"Tau aggregates")p(FPLX:PKA)p(HGNC:MAPT, pmod(Ph))
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:PICALM)
Jensbp(GO:aging)p(HGNC:FKBP5)path(MESH:"Alzheimer Disease")
Jensp(HGNC:CHRNA7)p(HGNC:CHRNA7)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Jensa(CHEBI:"lithium(1+)")bp(GO:autophagy)p(HGNC:HTT)
Jensa(CHEBI:"amyloid-beta")complex(GO:"NF-kappaB complex")p(HGNC:IL1B)
Jensp(HGNC:FKBP5)p(HGNC:MAPT, pmod(Ph, Ser, 202))path(MESH:"Alzheimer Disease")
Jenspath(MESH:"Alzheimer Disease")path(MESH:"Plaque, Amyloid")r(HGNC:"BACE1-AS")
Jensbp(GO:"MAPK cascade")p(FPLX:NFkappaB)p(HGNC:TNF)
Jensa(CHEBI:"amyloid-beta")p(HGNC:ABCB1)p(HGNC:APOE)
Jensa(CHEBI:"methylene blue")a(HBP:"Tau oligomers")bp(MESH:Autophagy)
Jensa(CHEBI:nicotine)a(MESH:"Dopaminergic Neurons")p(FPLX:CHRN)
Jensa(CHEBI:"amyloid-beta")a(HP:"interstitial fluid")bp(GO:aging)
Jensp(HGNC:MAPT)p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Jensbp(MESH:"Oxidative Stress")complex(GO:"NF-kappaB complex")path(MESH:"Alzheimer Disease")
Jenscomplex(a(GO:microtubule), p(HGNC:MAPT))p(FPLX:HSP90)p(HGNC:MAPT, pmod(Ph))
Jensa(HBP:"Tau aggregates")a(HBP:"Tau aggregates")p(HBP:"Tau isoform B (381 aa)", pmod(HBP:glycation))
Jensa(CHEBI:"iron(0)")p(HGNC:MAPT)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:CHRM1)
Jensa(CHEBI:"amyloid-beta")complex(GO:"NF-kappaB complex")p(HGNC:TNF)
Jensa(CHEBI:"methylene blue")bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")p(HGNC:MAPT)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:Nilvadipine)p(HGNC:SYK)
Jensbp(GO:"negative regulation of synaptic plasticity")p(FPLX:ERK)p(HGNC:CDK5)
Jensp(FPLX:ERK)p(HGNC:MAPT, pmod(Ph, Ser, 396))path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:nicotine)bp(GO:"MAPK cascade")
Jensm(MIRBASE:"hsa-mir-125b-1")p(HGNC:BCL2L2)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Jensa(HBP:"sonicated tau fibrils")a(HBP:"sonicated tau fibrils")a(HBP:"sonicated tau fibrils")
Jensp(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))p(HGNC:MAPT, var("?"))
Jensa(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide")a(CHEBI:"amyloid-beta polypeptide 42")p(HGNC:GSK3B, pmod(Ph, Ser, 9))
Jensa(HBP:"Tau oligomers")p(HGNC:MAPT)path(HBP:neurotoxicity)
Jensp(HGNC:AK1)p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")p(HGNC:TFEB)path(MESH:"Plaque, Amyloid")
Jensa(CHEBI:"amyloid-beta")p(HGNC:CHRNA4)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")bp(GO:"response to oxidative stress")bp(GO:autophagy)
Jensa(HBP:"Tau aggregates")a(HBP:"Tau aggregates")bp(MESH:Autophagy)
Jensbp(HBP:"protein aggregation")complex(p(HGNC:BAG6), p(HGNC:UBA3))p(MESH:Proteins, pmod(HBP:misfolding))
Jensa(HBP:"Corticobasal Degeneration")a(HBP:"Tau oligomers")p(HGNC:MAPT)
Jensa(CHEBI:"okadaic acid")p(FPLX:PPP2)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Jensa(CHEBI:"amyloid-beta polypeptide 42")p(FPLX:AMPK)p(HGNC:MAPT, pmod(Ph, Ser, 404))
Jensp(HGNC:RPTOR)p(HGNC:TARDBP)p(HGNC:TFEB)
Jensa(CHEBI:"amyloid-beta")bp(GO:"neuron death")path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")path(MESH:"Alzheimer Disease")
Jensp(HGNC:DAPK1)p(HGNC:MAPT)p(HGNC:PIN1, pmod(Ph, Ser, 71))
Jensa(CHEBI:"amyloid-beta")bp(HBP:"APP processing")complex(GO:"NF-kappaB complex")
Jensa(CHEBI:"amyloid-beta")a(GO:synapse)path(MESH:"Plaque, Amyloid")
Jensp(HGNC:MAPT, pmod(Ph, Ser, 422))path(MESH:"Alzheimer Disease")path(MESH:"Cognitive Dysfunction")
Jensa(CHEBI:"amyloid-beta")p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")path(HBP:neurotoxicity)
Jensa(HBP:"Tau isoform F (441 aa)")a(HBP:"Tau isoform F (441 aa)")path(MESH:"Protein Aggregation, Pathological")
Jensa(HBP:"protein aggregates")bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")path(MESH:"Alzheimer Disease")
Jensp(HBP:"phosphatase-activating domain")p(HGNC:MAPT, pmod(Ph, Ser, 199))path(MESH:"Alzheimer Disease")
Jensbp(GO:aging)p(HGNC:IL1B)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:galanthamine)bp(GO:cognition)path(MESH:"Alzheimer Disease")
Jensbp(GO:macroautophagy)p(HGNC:TFEB)path(MESH:"Plaque, Amyloid")
Jensbp(GO:aging)p(HGNC:MAPT)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"calcium(2+)")a(CHEBI:"calcium(2+)")p(HGNC:CHRNA7)
Jensa(HBP:HBP00093)bp(GO:autophagy)bp(MESH:"Endoplasmic Reticulum Stress")
Jensp(HBP:"cis p-tau")p(HBP:"cis p-tau")path(MESH:"Alzheimer Disease")
Jensa(HBP:"Tau oligomers")a(HBP:"Tau oligomers")path(MESH:Tauopathies)
Jensa(HBP:"Tau aggregates")a(HBP:"Tau aggregates")p(HGNC:HSPA1A)
Jensa(CHEBI:dopamine)a(CHEBI:methamphetamine)bp(GO:autophagy)
Jensa(CHEBI:sirolimus)p(HGNC:MAPT)p(HGNC:MAPT)
Jensa(CHEBI:"calcium(2+)")a(CHEBI:nicotine)p(HBP:"alpha-4 beta-2 nAChR")
Jenscomplex(GO:"NF-kappaB complex")path(MESH:"Alzheimer Disease")path(MESH:"Plaque, Amyloid")
Jensa(CHEBI:donepezil)p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")path(MESH:"Alzheimer Disease")
Jensa(MESH:"Embryonic Structures")a(MESH:antalarmin)bp(MESH:"Heat-Shock Response")
Jensa(GO:lysosome)a(GO:lysosome)a(GO:lysosome)
Jensa(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide")a(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:"amyloid-beta")
Jensa(CHEBI:wogonin)bp(GO:autophagy)p(HGNC:MAPT, pmod(Ph))
Jenscomplex(p(HGNC:FYN), p(HGNC:MAPT))p(HGNC:MAPT, pmod(Ph, Ser, 199))path(MESH:"Alzheimer Disease")
Jensp(HGNC:CDK5)p(HGNC:MAPT, pmod(Ph, Ser, 396))path(MESH:"Alzheimer Disease")
Jensp(HGNC:PRKN)p(HGNC:SNCA)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:acetylcholine)a(CHEBI:acetylcholine)p(HGNC:CHAT)
Jensbp(GO:macroautophagy)p(MGI:Mapt)p(MGI:Mapt, var("p.Pro301Leu"))
Jensa(HBP:"amyloid-beta oligomers")p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ph, Ser, 404))
Jensa(CHEBI:"amyloid-beta")p(HGNC:MARK4)path(MESH:"Alzheimer Disease")
Jensa(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide")bp(GO:learning)p(MGI:App, frag("25_35"))
Jensa(GO:"neurofibrillary tangle")p(HGNC:TGM1)path(MESH:"Supranuclear Palsy, Progressive")
Jensp(HGNC:CHRNA7)p(HGNC:CHRNA7)p(HGNC:CHRNA7)
Jensp(HGNC:MAPT)p(HGNC:NPEPPS)path(MESH:"Frontotemporal Dementia")
Jensa(CHEBI:"amyloid-beta")bp(GO:phagocytosis)complex(GO:"NLRP3 inflammasome complex")
Jensa(CHEBI:rivastigmine)p(HGNC:ABCB1)path(MESH:"Alzheimer Disease")
Jensa(HBP:"Tau oligomers")p(HGNC:MAPT)path(HBP:Neurodegeneration)
Jensa(CHEBI:acetylcholine)a(CHEBI:acetylcholine)p(HGNC:BCHE)
Jensa(CHEBI:"glutamate(1-)")a(GO:"excitatory synapse")complex(GO:"NF-kappaB complex")
Jenscomplex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG))complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG))complex(p(HGNC:CHRNA1), p(HGNC:CHRNA1), p(HGNC:CHRNB1), p(HGNC:CHRND), p(HGNC:CHRNG))
Jensa(HBP:"Tau aggregates")p(HGNC:MAPT, pmod(Ph))p(HGNC:MTOR)
Jensp(HGNC:TNF)path(MESH:"Alzheimer Disease")r(HGNC:BACE1)
Jensa(CHEBI:"calcium(2+)")a(CHEBI:"glutamate(2-)")p(HGNC:CHRNA7)
Jensa(MESH:"Neurofibrillary Tangles")p(HGNC:MAPT)p(HGNC:MAPT)
Jensbp(GO:"protein folding")bp(MESH:Aging)p(FPLX:HSP90)
Jensp(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu"))p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu"))p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu"))
Jensa(CHEBI:"amyloid-beta")complex(GO:"NF-kappaB complex")p(HGNC:IL6)
Jensa(CHEBI:"amyloid-beta")complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))path(MESH:"Alzheimer Disease")
Jenscomplex(GO:"filamentous actin")p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Jensa(GO:"neurofibrillary tangle")complex(GO:"NF-kappaB complex")path(MESH:"Alzheimer Disease")
Jensa(HBP:"Tau aggregates")complex(a(GO:microtubule), p(HGNC:MAPT))p(HGNC:MAPT, var("p.Val337Met"))
Jensa(CHEBI:"amyloid-beta")a(GO:lysosome)bp(GO:endocytosis)
Jensa(HBP:"Tau oligomers")p(HGNC:MAPT)path(MESH:"Brain Injuries, Traumatic")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")complex(GO:"TOR complex")
Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")
Jensa(CHEBI:"amyloid-beta")a(MESH:Synapses)p(FPLX:PI3K)
Jensp(HGNC:IL18)path(MESH:"Alzheimer Disease")path(MESH:Dementia)
Jensbp(GO:cognition)p(HGNC:MAPT, pmod(Ac, Lys, 174))path(HBP:Neurodegeneration)
Jensa(CHEBI:galanthamine)bp(GO:learning)path(MESH:"Alzheimer Disease")
Jensa(HBP:"dystrophic neurite")p(HGNC:ITPKB)path(MESH:"Alzheimer Disease")
Jensa(HBP:"Tau aggregates")a(HBP:"Tau aggregates")path(HBP:neurotoxicity)
Jensbp(GO:"MAPK cascade")p(HGNC:CHRNA7)path(MESH:"Alzheimer Disease")
Jensbp(GO:autophagy)p(MESH:Proteins, pmod(HBP:misfolding))path(MESH:"Neurodegenerative Diseases")
Jensa(HBP:"Tau aggregates")p(HGNC:MAPT, pmod(Ac, Lys, 259))path(MESH:"Alzheimer Disease")
Jensa(CHEBI:Temsirolimus)bp(GO:macroautophagy)p(HGNC:MAPT, pmod(Ph))
Jensa(CHEBI:acrolein)a(GO:"neurofibrillary tangle")path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")p(HGNC:NGFR)path(MESH:"Alzheimer Disease")
Jensbp(GO:macroautophagy)p(FPLX:AMPK)p(FPLX:mTORC1)
Jensp(HGNC:MAPT, pmod(Ph, Ser, 202))p(HGNC:MAPT, var("p.Glu391*"))path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:rosiglitazone)bp(GO:memory)
Jensa(CHEBI:"calcium(2+)")a(CHEBI:"calcium(2+)")a(CHEBI:"calcium(2+)")
Jensp(HGNC:GSK3B)p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Jensp(HBP:"4R tau")p(HGNC:MAPT, var("p.Gly272Val"))path(MESH:"Frontotemporal Dementia")
Jensp(HGNC:MAPT, pmod(HBP:hyperphosphorylation))p(HGNC:MAPT, pmod(NGlyco))path(MESH:"Alzheimer Disease")
Jensbp(GO:aging)bp(GO:locomotion)p(HGNC:MAPT)
Jensa(CHEBI:"amyloid-beta")bp(GO:"long-term synaptic potentiation")p(HGNC:RELA)
Jensp(FPLX:NFkappaB)p(FPLX:NFkappaB)p(HGNC:TNF)
Jensa(CHEBI:"amyloid-beta")bp(GO:"neuron death")complex(GO:"NF-kappaB complex")
Jensp(HGNC:IL18)p(HGNC:PYCARD)path(MESH:"Alzheimer Disease")
Jenscomplex(a(GO:microtubule), p(HGNC:MAPT))complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A))p(HGNC:MAPT, pmod(Ph))
Jensa(CHEBI:memantine)bp(GO:cognition)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:nicotine)bp(GO:memory)p(HGNC:CHRNA7)
Jensa(CHEBI:"amyloid-beta")a(GO:synapse)a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")
Jensbp(GO:"axonal transport")p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")a(MESH:Kidney)
Jensa(CHEBI:acetylcholine)a(CHEBI:galanthamine)p(HGNC:CHRNA7)
Jensg(HGNC:APOE)p(HGNC:APOE)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:"amyloid-beta")g(HBP:"APOE e4")
Jensa(CHEBI:acrolein)a(HBP:"Tau oligomers")path(MESH:"Alzheimer Disease")
Jensa(CHEBI:acetylcholine)bp(GO:"membrane depolarization")p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
Jensa(GO:microtubule)p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Jensa(HBP:HBP00006)p(HBP:HBP00053, var("p.Lys280del"))p(HBP:HBP00053, var("p.Lys280delinsProPro"))
Jensp(HGNC:MAPT, pmod(Ac, Lys, 353))p(HGNC:MAPT, pmod(Ac, Lys, 353))p(HGNC:MAPT, pmod(Ac, Lys, 353))
Jensp(HGNC:BACE1)p(HGNC:TNF)path(MESH:"Alzheimer Disease")
Jensp(FPLX:PPP2)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))path(MESH:"Alzheimer Disease")
Jensbp(GO:autophagy)p(HGNC:MAPT, pmod(Ph))p(HGNC:PPP2CA)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:resveratrol)p(HGNC:CAMKK2)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:IL1B)
Jensa(CHEBI:sirolimus)bp(GO:cognition)p(HGNC:MTOR)
Jensa(HBP:"Tau aggregates")p(HGNC:MAPT)path(MESH:"Alzheimer Disease")
Jensp(HGNC:SNCA, var("?"))p(HGNC:SNCA, var("?"))p(HGNC:SNCA, var("?"))
Jensp(HGNC:CDK5)p(HGNC:MAPT, pmod(Ph, Thr, 205))path(MESH:"Alzheimer Disease")
Jensbp(GO:cognition)p(HGNC:CHRNA7)p(HGNC:CHRNA7)
Jensa(CHEBI:"proteasome inhibitor")bp(GO:autophagy)p(HGNC:MAPT)
Jensbp(GO:macroautophagy)p(MGI:Mapt, var("p.Ala152Thr"))p(MGI:Mapt, var("p.Ala152Thr"))
Jensa(GO:"late endosome")p(MGI:Mapt)p(MGI:Mapt, var("p.Pro301Leu"))
Jensp(HGNC:MAPK1)p(HGNC:MAPT, pmod(Ph, Thr, 205))path(MESH:"Alzheimer Disease")
Jensp(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))path(HBP:Neurodegeneration)
Jensa(HBP:"Tau aggregates")p(HGNCGENEFAMILY:Caspases)path(MESH:"Neurofibrillary Tangles")
Jensp(HGNC:MAPT, pmod(Ac, Lys, 321))p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
Jensa(CHEBI:sirolimus)bp(GO:autophagy)p(HGNC:MAPT)
Jensa(CHEBI:"advanced glycation end-product")a(HBP:"Tau aggregates")complex(a(GO:microtubule), p(HGNC:MAPT))
Jensa(CHEBI:"amyloid-beta")a(PUBCHEM:49850262)bp(GO:autophagy)
Jensa(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor")p(FPLX:CHRN)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:rosiglitazone)a(HBP:HBP00018)
Jensp(HGNC:MAPT)p(HGNC:MAPT, pmod(Ac, Lys, 174))path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")complex(p(FPLX:"G_protein"), p(HGNC:CHRM1))
Jensa(CHEBI:"amyloid-beta")p(HGNC:RELA)path(MESH:"Alzheimer Disease")
Jensa(GO:"neurofibrillary tangle")a(HBP:"Tau fibrils")p(MGI:Tfeb)
Jensa(GO:"neurofibrillary tangle")g(HGNC:"MIR9-1")path(MESH:"Alzheimer Disease")
Jensp(HBP:"4R tau")p(HBP:"phosphatase-activating domain")path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")complex(GO:"NF-kappaB complex")complex(GO:"calcium- and calmodulin-dependent protein kinase complex")
Jensp(FPLX:NFkappaB)p(HGNC:IL18)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")bp(GO:"MAPK cascade")p(HGNC:TNF)
Jensp(HGNC:ADNP, pmod(MESH:Haploinsufficiency))path(MESH:"Alcohol Drinking")r(HGNC:ADNP)
Jensa(HBP:"Tau aggregates")a(PUBCHEM:9804992)p(FPLX:HDAC)
Jensbp(GO:"microtubule depolymerization")p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Jensbp(GO:autophagy)p(HGNC:HSPB1)p(HGNC:MAPT, pmod(Ph))
Jensa(CHEBI:"amyloid-beta")bp(GO:"apoptotic process")p(HGNC:CHRNA7)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:nicotine)p(HGNC:BCL2L1)
Jensa(GO:lysosome)p(HGNC:TARDBP)p(HGNC:TFEB)
Jensp(HGNC:MAPT, pmod(Ac, Lys, 280))p(HGNC:MAPT, pmod(Ac, Lys, 280))p(HGNC:MAPT, pmod(Ac, Lys, 280))
Jenscomplex(GO:"protein phosphatase type 2A complex")p(HGNC:MAPT, pmod(Ph))p(HGNC:PPP2R2A)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")
Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:nicotine)path(HBP:neurotoxicity)
Jensa(CHEBI:"methylene blue")bp(MESH:Autophagy)p(HGNC:MAPT)
Jensa(HBP:"Tau aggregates")p(HGNC:MAPT, pmod(Ac, Lys, 353))path(MESH:"Alzheimer Disease")
Jensp(HGNC:HSPB1)p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ph))
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(MGI:Chrna7)
Jensa(CHEBI:"amyloid-beta")p(FPLX:TLR)p(HGNC:IL1B)
Jensp(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356))p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356))p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356))
Jensa(HBP:"Tau oligomers")p(HGNC:MAPT)path(MESH:Tauopathies)
Jensp(FPLX:NFkappaB)p(HGNC:BACE1)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:nicotine)a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")
Jensbp(GO:autophagy)p(FPLX:mTORC1)p(HGNC:MAPT)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:metformin)bp(GO:macroautophagy)
Jensa(CHEBI:"amyloid-beta")r(HGNC:"BACE1-AS")r(HGNC:BACE1)
Jensa(CHEBI:Calpeptin)bp(GO:autophagy)p(HGNC:CAPN2)
Jensa(HBP:"Tau oligomers")a(HBP:"Tau oligomers")path(MESH:"Pick Disease of the Brain")
Jensp(FPLX:NFkappaB)p(HGNC:IL1B)path(MESH:"Alzheimer Disease")
Jensa(HBP:"Tau isoform F (441 aa)")a(HBP:"Tau isoform F (441 aa)")a(HBP:"Tau isoform F (441 aa)")
Jensa(CHEBI:methamphetamine)bp(GO:autophagy)p(HGNC:DRD1)
Jensa(CHEBI:sirolimus)bp(GO:autophagy)path(MESH:"Huntington Disease")
Jensa(HBP:"Tau aggregates")p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))path(MESH:Tauopathies)
Jensa(HBP:"Corticobasal Degeneration")a(HBP:"Tau oligomers")a(HBP:"Tau oligomers")
Jensa(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide")a(CHEBI:"amyloid-beta polypeptide 42")p(HGNC:BACE1)
Jensbp(GO:"neuron death")complex(GO:"NF-kappaB complex")path(MESH:"Alzheimer Disease")
Jensp(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))p(HGNC:SQSTM1)
Jensa(CHEBI:"amyloid-beta")a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")bp(GO:memory)
Jensa(CHEBI:"amyloid-beta")bp(GO:aging)p(HGNC:IL1B)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:Anatabine)p(HGNC:CHRNA7)
Jensa(HBP:"Tau oligomers")p(HGNC:MAPT, pmod(Ph))path(HBP:neuroinflammation)
Jensbp(GO:"cellular senescence")p(MGI:Dyrk1a)p(MGI:Mapt)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:donepezil)p(HGNC:LRP1)
Jensp(HGNC:CDC37)p(HGNC:MAPT)p(HGNC:MAPT)
Jensa(HBP:"protein aggregates")bp(GO:autophagy)path(MESH:"Neurodegenerative Diseases")
Jensbp(GO:"microglial cell activation")p(HGNC:NR1H3)path(MESH:"Alzheimer Disease")
Jenscomplex(p(HGNC:FYN), p(HGNC:MAPT))p(HGNC:MAPT, pmod(Ph, Ser, 208))path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"alpha,alpha-trehalose")a(CHEBI:"amyloid-beta")bp(GO:autophagy)
Jensa(PUBCHEM:16057918)complex(GO:"NF-kappaB complex")p(HGNC:BCL2L1)
Jensbp(GO:"neuron death")path(MESH:"Alzheimer Disease")path(MESH:Atrophy)
Jensa(CHEBI:"calcium(2+)")a(CHEBI:dopamine)a(CHEBI:nicotine)
Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:"amyloid-beta")bp(GO:"long-term synaptic potentiation")
Jensp(FPLX:ERK)p(HGNC:CDK5)path(MESH:"Alzheimer Disease")
Jensa(PUBCHEM:675434)p(HGNC:MAPT)p(HGNC:MAPT)
Jenscomplex(GO:"NF-kappaB complex")p(HGNC:BACE1)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:oleocanthal)p(HGNC:LRP1)
Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:"amyloid-beta")p(HGNC:BACE1)
Jensp(HGNC:MAPT, pmod(Ac, Lys, 280))p(HGNC:MAPT, pmod(Ph, Ser, 262))path(MESH:"Alzheimer Disease")
Jensbp(GO:"neuron death")p(HGNC:TNF)path(MESH:"Alzheimer Disease")
Jensbp(GO:"microglial cell activation")p(MGI:Syk)p(MGI:Syk, pmod(Ph))
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:rivastigmine)p(FPLX:CHRN)
Jensp(FPLX:NFkappaB)p(HGNC:TNF)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")bp(GO:"cell death")p(HGNC:CHRNA7)
Jensa(HBP:"Tau aggregates")bp(GO:"lysosomal microautophagy")path(MESH:"Alzheimer Disease")
Jensa(HBP:"Tau oligomers")p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))path(MESH:Tauopathies)
Jensa(CHEBI:"amyloid-beta")p(HGNC:IL1B)p(HGNC:NFKB1)
Jensa(HBP:"Tau oligomers")a(HBP:"Tau oligomers")a(HBP:"Tau oligomers")
Jensa(CHEBI:"trichostatin A")p(FPLX:HDAC)p(HGNC:MAPT, pmod(Ac))
Jensa(HBP:HBP00074)path(MESH:"Alzheimer Disease")path(MESH:"Cognitive Dysfunction")
Jensp(HGNC:MAPT, pmod(Ph, Ser, 202))p(HGNC:MAPT, var("p.Pro301Ser"))p(HGNC:MAPT, var("p.Pro301Ser"))
Jensbp(GO:cognition)p(HGNC:CHRNA7)path(MESH:"Alzheimer Disease")
Jensp(HGNC:CDK2)p(HGNC:MAPT, pmod(Ph, Ser, 404))path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:nicotine)p(HGNC:BCL2)
Jensp(HGNC:APP, frag("672_713"))p(HGNC:BACE1)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:acetylcholine)a(MESH:"Cholinesterase Inhibitors")
Jensa(CHEBI:"amyloid-beta")bp(GO:"MAPK cascade")p(HGNC:CHRM1)
Jensa(HBP:"protein aggregates")bp(GO:autophagy)path(MESH:"Amyotrophic Lateral Sclerosis")
Jensbp(GO:"response to misfolded protein")p(HGNC:ERN1)p(HGNC:XBP1)
Jensp(FPLX:NFkappaB)p(HGNC:BACE1)p(HGNC:UCHL1)
Jensa(CHEBI:"nitric oxide")a(CHEBI:peroxynitrite)complex(GO:"NF-kappaB complex")
Jensa(CHEBI:"amyloid-beta")bp(GO:aging)bp(GO:locomotion)
Jensp(MGI:Mapt)p(MGI:Mapt, var("p.Pro301Leu"))p(MGI:Mapt, var("p.Pro301Leu"))
Jensa(MESH:"Amyloid beta-Peptides")complex(GO:"NF-kappaB complex")p(HGNC:TNF)
Jensa(HBP:"Tau aggregates")complex(a(GO:microtubule), p(HGNC:MAPT))p(HGNC:MAPT, var("p.Gly272Val"))
Jensa(CHEBI:"amyloid-beta")complex(GO:"NF-kappaB complex")path(MESH:"Plaque, Amyloid")
Jensa(CHEBI:"amyloid-beta")bp(GO:aging)p(HGNC:IL18)
Jensbp(GO:autophagy)p(HGNC:SQSTM1)p(MESH:Proteins, pmod(HBP:misfolding))
Jensa(CHEBI:"amyloid-beta")a(CHEBI:simvastatin)bp(GO:"apoptotic process")
Jensa(CHEBI:dopamine)a(CHEBI:nicotine)p(HGNC:CHRNA7)
Jensa(CHEBI:"amyloid-beta")path(MESH:"Alzheimer Disease")path(MESH:"Diabetes Mellitus")
Jensa(HBP:"Tau oligomers")p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")p(HGNC:RAB5A)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:donepezil)p(HGNC:ABCB1)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")bp(GO:"lysosomal protein catabolic process")
Jensa(CHEBI:acetylcholine)a(CHEBI:acetylcholine)a(CHEBI:acetylcholine)
Jensa(HBP:"amyloid-beta aggregates")p(MGI:Syk)p(MGI:Syk, pmod(Ph))
Jenscomplex(p(HGNC:FYN), p(HGNC:MAPT))p(HGNC:MAPT, pmod(Ph, Thr, 205))path(MESH:"Alzheimer Disease")
Jensa(CHEBI:sirolimus)p(HGNC:SNCA)path(MESH:"Parkinson Disease")
Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:"amyloid-beta")p(HGNC:IDE)
Jensa(MESH:Nicotine)p(HGNC:CHRNA7)p(HGNC:CHRNA7)
Jensm(MIRBASE:"hsa-mir-125b-1")p(HGNC:DUSP6)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Jensa(CHEBI:acetylcholine)a(CHEBI:galanthamine)path(MESH:"Alzheimer Disease")
Jensp(HGNC:CDC37)p(HGNC:CDK5)p(HGNC:MAPT, pmod(Ph, Ser, 199))
Jensa(CHEBI:"amyloid-beta")p(HGNC:APP)p(HGNC:DKK1)
Jensa(CHEBI:"amyloid-beta")p(FPLX:JNK)p(HGNC:DKK1)
Jensp(HGNC:TARDBP)p(HGNC:TFEB)path(MESH:"Frontotemporal Dementia")
Jensp(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))path(MESH:"Frontotemporal Dementia")
Jensa(CHEBI:"amyloid-beta")complex(GO:"NF-kappaB complex")p(HGNC:BCL2L1)
Jensa(CHEBI:rolipram)p(HGNC:MAPT)p(HGNC:MAPT)
Jensa(CHEBI:"amyloid-beta polypeptide 42")a(MESH:Microglia)p(MESH:"I-kappa B Proteins", pmod(Ph))
Jensa(CHEBI:"amyloid-beta")p(HGNC:BACE1)p(HGNC:SUMO3)
Jensa(MESH:Morphine)p(FPLX:IKB)p(FPLX:NFkappaB)
Jensa(MESH:"alpha7 Nicotinic Acetylcholine Receptor")bp(GO:"ERK1 and ERK2 cascade")bp(GO:"apoptotic process")
Jensa(HBP:"Tau oligomers")p(HGNC:MAPT, pmod(Ph))path(HBP:Neurodegeneration)
Jensa(CHEBI:resveratrol)p(HGNC:MID1)p(HGNC:PPP2CA)
Jensbp(GO:cognition)p(HGNC:MAPT, pmod(Ph))p(HGNC:MAPT, var("p.Lys280del"))
Jensa(GO:"neurofibrillary tangle")p(HGNC:IL1B)path(MESH:"Alzheimer Disease")
Jensp(HGNC:MTOR)p(HGNC:SNCA)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:nicotine)bp(MESH:Neuroprotection)
Jensp(HGNC:MAPT)p(HGNC:NPEPPS)p(HGNCGENEFAMILY:Aminopeptidases)
Jensbp(GO:autophagy)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))p(HGNC:SQSTM1)
Jensp(HGNC:BACE1)p(HGNC:NGFR)path(MESH:"Alzheimer Disease")
Jensa(HBP:"Tau aggregates")a(HBP:"Tau aggregates")p(HGNC:SYK, pmod(Ph))
Jensa(CHEBI:"okadaic acid")complex(GO:"protein phosphatase type 2A complex")p(HGNC:MAPT, pmod(Ph))
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")complex(GO:"NLRP3 inflammasome complex")
Jensp(HGNC:IL1B)path(MESH:"Alzheimer Disease")path(MESH:Dementia)
Jensa(GO:lysosome)a(HBP:"Tau aggregates")path(HBP:Neurodegeneration)
Jensa(CHEBI:"amyloid-beta polypeptide 42")bp(MESH:Neuroprotection)p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
Jensa(CHEBI:"amyloid-beta")a(HBP:"dystrophic neurite")path(MESH:"Alzheimer Disease")
Jensa(GO:"neurofibrillary tangle")p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del"))p(MGI:Mapt)
Jensa(PUBCHEM:675434)p(FPLX:Proteasome)p(HGNC:USP14)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:acetylcholine)a(MESH:D002800)
Jensa(HBP:HBP00093)bp(GO:autophagy)p(HGNC:HDAC6)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:TFEB)
Jensa(HBP:"Tau aggregates")complex(a(GO:microtubule), p(HGNC:MAPT))p(HGNC:MAPT, var("p.Pro301Leu"))
Jensa(HBP:"Tau aggregates")a(HBP:"Tau oligomers")p(HGNC:MAPT, pmod(Ph))
Jensbp(GO:endocytosis)g(HBP:"APOE e4")p(HBP:"APP C-terminally truncated carboxyl-terminal fragments")
Jensbp(GO:"mitochondrion transport along microtubule")composite(p(HBP:"Tau isoform F (441 aa)"), p(HGNC:STUB1))p(HBP:"Tau C3")
Jensa(CHEBI:"amyloid-beta")complex(GO:"NF-kappaB complex")p(HGNC:SYK)
Jensa(CHEBI:"amyloid-beta")p(HGNC:MAPK14)p(HGNC:RELA)
Jensa(CHEBI:acrolein)bp(GO:"neuron death")path(MESH:"Alzheimer Disease")
Jensa(CHEBI:sirolimus)bp(MESH:Autophagy)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")p(FPLX:NFkappaB)path(MESH:"Alzheimer Disease")
Jensp(HGNC:DAPK1)p(HGNC:MAPT)p(HGNC:MAPT)
Jensa(HBP:"Tau aggregates")complex(a(GO:microtubule), p(HGNC:MAPT))p(HGNC:MAPT, var("p.Asn279Lys"))
Jensp(HGNC:CDK1)p(HGNC:MAPT, pmod(Ph, Thr, 231))path(MESH:"Alzheimer Disease")
Jensbp(GO:"microtubule polymerization")p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Jensbp(GO:"neuron death")p(HGNC:MMP2)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"methylene blue")bp(GO:autophagy)p(HGNC:MAPT)
Jenscomplex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph)))p(HGNC:HSPB1)p(HGNC:MAPT, pmod(Ph))
Jensbp(GO:"chaperone-mediated autophagy")p(MGI:Mapt, var("p.Pro301Leu"))path(MESH:"Proteostasis Deficiencies")
Jensa(CHEBI:"Hsp90 inhibitor")a(CHEBI:"N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal")p(HGNC:MAPT)
Jensa(CHEBI:galanthamine)p(MGI:App, frag("25_35"))path(MESH:"Spatial Memory")
Jensp(FPLX:NFkappaB)p(FPLX:NFkappaB)p(HGNC:IL1B)
Jensbp(GO:autophagy)p(HGNC:MAPT)path(MESH:Tauopathies)
Jensa(GO:"neurofibrillary tangle")p(HGNC:TNF)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")p(HGNC:CHRNA3)path(MESH:"Alzheimer Disease")
Jensa(HP:"glymphatic system")p(HGNC:MAPT)path(MESH:"Brain Injuries, Traumatic")
Jenscomplex(GO:"protein phosphatase type 2A complex")p(HGNC:CDK5)p(HGNC:MAPT, pmod(Ph))
Jensa(GO:"neurofibrillary tangle")p(HGNC:MAPT, pmod(Ph))p(HGNC:TNF)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")a(CHEBI:rosiglitazone)
Jensa(CHEBI:acetylcholine)p(HGNC:BCHE)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:sirolimus)bp(MESH:Autophagy)p(HGNC:MAPT, pmod(Ph))
Jensa(HBP:"Corticobasal Degeneration")p(HGNC:MAPT)p(HGNC:MAPT)
Jensa(CHEBI:"amyloid-beta")bp(GO:"lysosomal protein catabolic process")p(HGNC:PSEN1, var("?"))
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")bp(GO:phagocytosis)
Jensa(CHEBI:"amyloid-beta")p(HGNC:TNF)path(MESH:"Alzheimer Disease")
Jensp(HGNC:MAPT)p(HGNC:MAPT)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta polypeptide 42")a(MESH:Microglia)bp(GO:"peroxisome proliferator activated receptor signaling pathway")
Jensa(HBP:"Tau aggregates")p(FPLX:PKA)p(HGNC:SYK)
Jensa(CHEBI:"amyloid-beta")bp(GO:"canonical Wnt signaling pathway")p(HGNC:DKK1)
Jensa(HBP:"alpha-synuclein aggregates")a(MESH:"HSP70 Heat-Shock Proteins")g(NCBIGENE:406950)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:AQP4)
Jensp(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")path(MESH:"Alzheimer Disease")path(MESH:Aging)
Jensbp(GO:"cell death")p(HGNC:RNF19A)p(HGNC:SOD1, var("?"))
Jensa(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide")a(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")
Jensa(CHEBI:dopamine)a(CHEBI:methamphetamine)a(CHEBI:nicotine)
Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:"amyloid-beta")a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")
Jensp(HGNC:CDC37)p(HGNC:CDK5)p(HGNC:MAPT, pmod(Ph, Thr, 231))
Jensp(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404))p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404))p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404))
Jensa(HBP:"Tau oligomers")a(HBP:"Tau oligomers")bp(HBP:neurotoxicity)
Jensbp(GO:autophagy)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))path(MESH:Tauopathies)
Jensa(CHEBI:"amyloid-beta polypeptide 42")a(CHEBI:"amyloid-beta")a(MESH:Microglia)
Jensp(HGNC:MAPT)p(HGNC:MAPT)p(HGNC:TREM2)
Jensa(HBP:"amyloid-beta aggregates")p(HGNC:APP, var("?"))path(MESH:"Alzheimer Disease")
Jenscomplex(p(HGNC:FYN), p(HGNC:MAPT))p(HGNC:MAPT)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:galanthamine)bp(MESH:Neuroprotection)p(HGNC:CHRNA7)
Jensp(HBP:"cis p-tau")p(HBP:"cis p-tau")p(HGNC:PIN1)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:pioglitazone)p(HGNC:PPARG)
Jensbp(GO:"microglial cell activation")p(HGNC:IL1B)path(MESH:"Alzheimer Disease")
Jensa(HBP:"Tau aggregates")a(HBP:"Tau oligomers")complex(GO:"proteasome complex")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:Temsirolimus)bp(GO:autophagy)
Jensbp(GO:"neuron death")complex(GO:"NF-kappaB complex")p(HGNC:TNF)
Jensa(CHEBI:"amyloid-beta")p(HGNC:MMP2)path(MESH:"Alzheimer Disease")
Jensa(GO:"neurofibrillary tangle")p(ECCODE:"2.3.2.13")path(MESH:"Alzheimer Disease")
Jensp(HGNC:MAPT)p(HGNC:MAPT, var("?"))path(MESH:"Alzheimer Disease")
Jensp(HBP:HBP00053, var("p.Lys280del"))p(HBP:HBP00053, var("p.Lys280del"))p(HBP:HBP00053, var("p.Lys280del"))
Jensa(CHEBI:acetylcholine)bp(GO:"membrane depolarization")p(FPLX:CHRN)
Jensa(CHEBI:"amyloid-beta")bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")p(HGNC:IDE)
Jensp(HGNC:PRNP)p(HGNC:PRNP)p(HGNC:PRNP)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:nicotine)bp(GO:"long-term synaptic potentiation")
Jensa(CHEBI:"alpha-tocopherol")a(CHEBI:"amyloid-beta")bp(GO:memory)
Jensa(HBP:"amyloid-beta oligomers")p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356))p(HGNC:MAPT, pmod(Ph, Ser, 262), pmod(Ph, Ser, 356))
Jensp(HGNC:MAPT)p(HGNC:MAPT, pmod(Ac, Lys, 174))path(HBP:Neurodegeneration)
Jensa(HBP:"amyloid-beta aggregates")path(HBP:"mitochondrial dysfunction")path(MESH:"Alzheimer Disease")
Jensbp(GO:"neuron death")p(MGI:Cdk5)p(MGI:Cdk5r1)
Jensbp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")p(HGNC:PRNP)p(HGNC:PRNP)
Jensbp(GO:learning)p(HGNC:SIRT1)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"reactive oxygen species")complex(GO:"NF-kappaB complex")p(FPLX:PKC)
Jensa(CHEBI:"amyloid-beta")p(HGNC:ADAM10)p(HGNC:APP)
Jensa(CHEBI:acetylcholine)a(CHEBI:acetylcholine)p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
Jensp(HGNC:MAPT, pmod(OGlyco))p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
Jensa(CHEBI:acetylcholine)a(CHEBI:acetylcholine)p(HGNC:ACHE)
Jensa(CHEBI:"amyloid-beta")p(HGNC:BACE1)p(HGNC:SYK)
Jensa(CHEBI:"amyloid-beta polypeptide 42")a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine")p(HGNC:CHRNA7)
Jensa(CHEBI:"amyloid-beta")p(HGNC:CHRM1)p(HGNC:MAPT, pmod(Ph))
Jensa(HBP:"Tau aggregates")a(MESH:Autophagosomes)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")bp(GO:"inflammatory response")p(HGNC:DKK1)
Jensa(HBP:HBP00093)bp(GO:autophagy)p(HGNC:TFEB)
Jensp(HGNC:MAPT, pmod(Ph))p(HGNC:PPP5C)path(MESH:"Alzheimer Disease")
Jensbp(GO:locomotion)p(HGNC:MAPT)p(HGNC:ZC3H14)
Jensa(CHEBI:sirolimus)bp(GO:"cell death")p(HGNC:MAPT)
Jensp(HGNC:MAPT, pmod(Ph))p(HGNC:MAPT, pmod(Ub))path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:ABCB1)
Jensa(HBP:"Tau aggregates")a(HBP:"Tau aggregates")a(MESH:Autophagosomes)
Jensp(HGNC:MAPT, pmod(Ac, Lys, 290))p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
Jensp(HGNC:MAPT, pmod(NGlyco))p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
Jensp(HGNC:CDK2)p(HGNC:MAPT, pmod(Ph, Ser, 199))path(MESH:"Alzheimer Disease")
Jenspath(MESH:"Alzheimer Disease")path(MESH:"Cognitive Dysfunction")path(MESH:"Plaque, Amyloid")
Jensbp(GO:"chaperone-mediated autophagy")p(MGI:Mapt)p(MGI:Mapt, var("p.Pro301Leu"))
Jensa(GO:"neurofibrillary tangle")p(HGNC:GSK3B)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Jensa(CHEBI:"amyloid-beta")p(HBP:"Tau aggregates")p(HGNC:MAPT)
Jensa(CHEBI:"amyloid-beta")bp(MESH:"Neuronal Outgrowth")complex(GO:"NF-kappaB complex")
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(MGI:Dyrk1a)
Jensa(CHEBI:"amyloid-beta")p(HGNC:MTOR)p(HGNC:TARDBP)
Jensa(HBP:"Tau aggregates")complex(a(GO:microtubule), p(HGNC:MAPT))p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Jensa(CHEBI:"amyloid-beta")bp(GO:autophagy)p(HGNC:MAPK8)
Jenscomplex(GO:"NF-kappaB complex")p(HGNC:TNF)path(MESH:"Alzheimer Disease")
Jenscomplex(p(HGNC:FYN), p(HGNC:MAPT))p(HGNC:FYN)path(MESH:"Alzheimer Disease")
Jensa(CHEBI:"methylene blue")bp(MESH:Autophagy)p(HGNC:MAPT, pmod(Ph))
Jensa(MESH:Proteins)a(MESH:Proteins)bp(GO:endocytosis)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:simvastatin)a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")
Jensa(CHEBI:"amyloid-beta")p(HGNC:NFKB1)path(MESH:Anxiety)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")a(CHEBI:Nilvadipine)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:nicotine)p(HGNC:BAX)
Jensa(CHEBI:"amyloid-beta")a(CHEBI:acetylcholine)p(HGNC:ACHE)
Jensbp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")p(HGNC:MAPT)p(HGNC:SQSTM1)
Increase Mismatcha(CHEBI:"amyloid-beta")p(HGNC:RELA)bp(GO:"apoptotic process")
Increase Mismatcha(CHEBI:"amyloid-beta")p(HGNC:CHRNA3)path(MESH:"Alzheimer Disease")
Increase Mismatcha(CHEBI:"amyloid-beta")path(MESH:"Plaque, Amyloid")p(HGNC:MMP2)
Increase Mismatcha(CHEBI:"amyloid-beta")p(HGNC:CHRNA7)path(MESH:"Alzheimer Disease")
Increase Mismatcha(CHEBI:"amyloid-beta")p(HGNC:CHRNA4)path(MESH:"Alzheimer Disease")
Increase Mismatchpath(MESH:"Alzheimer Disease")a(GO:autophagosome)p(HGNC:CTSD)
Increase Mismatchpath(MESH:"Alzheimer Disease")bp(GO:"neuron apoptotic process")p(HGNC:HSPB1)
Increase Mismatchpath(MESH:"Alzheimer Disease")path(MESH:Dementia)p(HGNC:MAPT)
Increase Mismatchpath(MESH:"Alzheimer Disease")p(HGNC:MAPT, pmod(Ph, Thr, 231))p(HGNC:MAPT)
Increase Mismatchpath(MESH:"Alzheimer Disease")a(GO:lysosome)p(HGNC:CTSD)
Increase Mismatchp(HGNC:MAPT, pmod(Ph))bp(GO:cognition)path(MESH:"Alzheimer Disease")
Increase Mismatchp(HGNC:MAPT)p(HGNC:GSK3B)bp(GO:neurogenesis)
Increase Mismatchp(HGNC:MAPT)a(GO:microtubule)p(HGNC:MAPT)
Increase Mismatchp(HGNC:MAPT)complex(a(GO:microtubule), p(HGNC:MAPT))a(HBP:"Tau aggregates")
Increase Mismatchp(HGNC:MAPT)p(HGNC:MAPT)a(MESH:Neurons)
Increase Mismatcha(CHEBI:"reactive oxygen species")bp(GO:neurogenesis)p(FPLX:ERK)
Increase Mismatcha(CHEBI:galanthamine)a(CHEBI:acetylcholine)bp(GO:cognition)
Increase Mismatcha(CHEBI:acetylcholine)bp(GO:"calcium ion transport")a(HBP:"alpha-4 beta-2 nAChR")
Increase Mismatchbp(GO:autophagy)a(HBP:"alpha-synuclein oligomers")a(HBP:"alpha-synuclein aggregates")
Increase Mismatchm(MIRBASE:"hsa-mir-125b-1")p(HGNC:CDK5)p(HGNC:CDK5R1)
Increase Mismatchg(HBP:"APOE e4")a(CHEBI:"amyloid-beta polypeptide 42")path(MESH:"Alzheimer Disease")
Increase Mismatcha(CHEBI:"methylene blue")bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")bp(GO:autophagy)
Increase Mismatchp(HGNC:APP, var("?"))bp(GO:endocytosis)path(MESH:"Alzheimer Disease")
Increase Mismatchbp(GO:"synaptic transmission, cholinergic")bp(GO:cognition)a(CHEBI:acetylcholine)
Increase Mismatchp(HGNC:LRP1)a(CHEBI:"amyloid-beta")p(HGNC:APOE)
Increase Mismatchp(HGNC:DISC1, var("?"))path(MESH:Schizophrenia)p(HGNC:MTOR)
Increase Mismatcha(CHEBI:nicotine)bp(GO:cognition)a(CHEBI:acetylcholine)
Increase Mismatcha(MESH:"Cholinesterase Inhibitors")bp(GO:cognition)a(CHEBI:acetylcholine)
Increase Mismatchp(HGNC:CHRM1)a(CHEBI:acetylcholine)bp(GO:cognition)
Increase Mismatcha(CHEBI:"nicotinic acetylcholine receptor agonist")a(CHEBI:acetylcholine)bp(GO:cognition)
Increase Mismatcha(PUBCHEM:9867750)bp(GO:cognition)a(CHEBI:acetylcholine)
Increase Mismatchp(HGNC:PPARG)p(HGNC:APOE)a(CHEBI:"amyloid-beta")
Increase Mismatchp(HGNC:NR1H3)p(HGNC:APOE)a(CHEBI:"amyloid-beta")
Increase Mismatchp(HGNC:IDE)bp(GO:macroautophagy)a(CHEBI:"amyloid-beta")
Increase Mismatchp(HGNC:SQSTM1)bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")bp(GO:autophagy)
Increase Mismatchcomplex(GO:"protein phosphatase type 2A complex")p(HGNC:MAPT, pmod(Ph))rxn(reactants(p(HGNC:MAPT, pmod(Ph))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT)))
Increase Mismatchp(FPLX:HSP90)bp(GO:autophagy)bp(GO:"proteasomal protein catabolic process")
Increase Mismatchp(HGNC:HSPB1)bp(GO:autophagy)bp(GO:"proteasomal protein catabolic process")
Increase Mismatchp(HGNC:TFEB)bp(GO:macroautophagy)a(CHEBI:"amyloid-beta")
Increase Mismatchbp(GO:"protein K63-linked ubiquitination")complex(GO:"proteasome complex")bp(GO:autophagy)
Increase Mismatchp(HGNC:VCP)bp(GO:autophagy)bp(GO:"proteasomal protein catabolic process")
Increase Mismatcha(MESH:"Heat-Shock Proteins")bp(GO:"proteasomal protein catabolic process")bp(GO:autophagy)
Increase Mismatchp(HGNC:HDAC6)p(MESH:Proteins, pmod(Ub))bp(GO:"stress granule assembly")
Increase Mismatchp(INTERPRO:"Heat shock protein 70 family")bp(GO:autophagy)bp(GO:"proteasomal protein catabolic process")
Increase Mismatcha(CHEBI:rolipram)p(HGNC:MAPT)complex(GO:"proteasome complex")
Increase Mismatchcomplex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(Ph)))p(HGNC:MAPT, pmod(Ph))rxn(reactants(p(HGNC:MAPT, pmod(Ph))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT)))
Increase Mismatchp(HGNC:ABCB1)a(CHEBI:"amyloid-beta")p(HGNC:APOE)
Increase Mismatchp(HGNC:DAPK1)p(HGNC:MAPT, pmod(Ph, Ser, 262))bp(GO:"apoptotic process")
Increase Mismatchp(HGNC:DAPK1)bp(GO:"apoptotic process")p(HGNC:MAPT, pmod(Ph, Thr, 231))
Increase Mismatchp(HGNC:DAPK1)bp(GO:"apoptotic process")p(HGNC:MAPT, pmod(Ph, Ser, 396))
Decrease Mismatcha(CHEBI:"amyloid-beta")complex(GO:"proteasome complex")a(CHEBI:"amyloid-beta")
Decrease Mismatcha(CHEBI:"amyloid-beta")path(HBP:Neurodegeneration)bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")
Decrease Mismatchpath(MESH:"Alzheimer Disease")a(MESH:Neurons)p(FPLX:CHRN)
Decrease Mismatchpath(MESH:"Alzheimer Disease")a(CHEBI:acetylcholine)bp(GO:cognition)
Decrease Mismatchbp(MESH:Aging)bp(GO:autophagy)bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")
Decrease Mismatcha(CHEBI:sirolimus)p(HGNC:MTOR)path(MESH:Schizophrenia)
Decrease Mismatchp(HGNC:MAPT, pmod(Ph))p(HGNC:MAPT)complex(GO:"proteasome complex")
Decrease Mismatchp(HGNC:MAPT)path(HBP:Neurodegeneration)bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")
Decrease Mismatchp(HGNC:MAPT)bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")bp(GO:autophagy)
Decrease Mismatchp(HGNC:LRRK2, var("?"))bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")bp(GO:autophagy)
Decrease Mismatchp(HGNC:HTT, var("?"))complex(GO:"proteasome complex")bp(GO:autophagy)
Decrease Mismatchp(HGNC:HTT, var("?"))bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")bp(GO:autophagy)
Decrease Mismatcha(PUBCHEM:155160)a(CHEBI:"amyloid-beta polypeptide 42")a(HBP:"amyloid-beta aggregates")
Decrease Mismatcha(CHEBI:galanthamine)p(HGNC:ACHE)path(MESH:"Alzheimer Disease")
Decrease Mismatcha(PUBCHEM:164676)p(HGNC:RELA)bp(GO:"apoptotic process")
Decrease Mismatchp(HGNC:MAPT, pmod(HBP:hyperphosphorylation))a(GO:synapse)p(HGNC:MAPT)
Decrease Mismatchp(HGNC:MAPT, pmod(HBP:hyperphosphorylation))p(HGNC:MAPT)a(GO:microtubule)
Decrease Mismatcha(CHEBI:donepezil)p(HGNC:ACHE)path(MESH:"Alzheimer Disease")
Decrease Mismatcha(CHEBI:rivastigmine)p(HGNC:ACHE)path(MESH:"Alzheimer Disease")
Decrease Mismatcha(CHEBI:"lithium(1+)")p(HGNC:MTOR)path(MESH:Schizophrenia)
Decrease Mismatcha(CHEBI:"EC 3.1.1.7 (acetylcholinesterase) inhibitor")p(HGNC:ACHE)path(MESH:"Alzheimer Disease")
Decrease Mismatcha(CHEBI:"okadaic acid")complex(GO:"protein phosphatase type 2A complex")p(HGNC:PPME1)
Decrease Mismatcha(CHEBI:"microcystin-LR")complex(GO:"protein phosphatase type 2A complex")p(HGNC:PPME1)
Decrease Mismatchp(HGNC:STIP1)p(HGNC:MAPT)p(FPLX:HSP90)
Decrease Mismatcha(CHEBI:lactacystin)p(HGNC:MAPT)complex(GO:"proteasome complex")
Decrease Mismatchp(HGNC:CDC37)p(HGNC:MAPT)p(FPLX:HSP90)
Decrease Mismatchp(HGNC:USP14)p(HGNC:MAPT)complex(GO:"proteasome complex")
Decrease Mismatcha(CHEBI:tanespimycin)p(HGNC:MAPT)p(FPLX:HSP90)
Decrease Mismatchp(FPLX:mTORC1)bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")bp(GO:autophagy)
Decrease Mismatcha(CHEBI:"5-chloro-7-iodoquinolin-8-ol")a(CHEBI:"amyloid-beta polypeptide 42")a(HBP:"amyloid-beta aggregates")
Decrease Mismatcha(CHEBI:celastrol)p(HGNC:MAPT)p(FPLX:HSP90)
Decrease Mismatcha(PUBCHEM:135566354)p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ph, Thr, 231))
Decrease Mismatcha(CHEBI:"withaferin A")p(HGNC:MAPT)p(FPLX:HSP90)
+ + + + + + pubmed:30027901 + + bp(GO:"response to drug") decreases path(MESH:Anger) + + + + + + + pubmed:30027901 + + bp(GO:"response to drug") decreases path(MESH:Depression) + + + + + + + pubmed:22020111 + + a(CHEBI:cocaine) decreases act(p(HGNC:SLC7A11)) + + + + + + + pubmed:24590577 + + a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases p(MGI:Bace1) + + + + + + + pubmed:18986241 + + a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases p(MGI:Bace1) + + + + + + + pubmed:24590577 + + a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases a(CHEBI:amyloid-beta) + + + + + + + pubmed:24590577 + + a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases path(MESH:Tauopathies) + + + + + + + pubmed:18986241 + + a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases path(MESH:Tauopathies) + + + + + + + pubmed:24590577 + + a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") increases act(p(FPLX:PKC)) + + + + + + + pubmed:24590577 + + a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases act(p(HGNC:GSK3B)) + + + + + + + pubmed:24590577 + + a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases path(MESH:"Plaque, Amyloid") + + + + + + + pubmed:24590577 + + a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:24590577 + + a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") increases bp(GO:memory) + + + + + + + pubmed:24590577 + + a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") increases bp(GO:learning) + + + + + + + pubmed:24590577 + + a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases a(CHEBI:"amyloid-beta polypeptide 42") + + + + + + + pubmed:18986241 + + a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases a(CHEBI:"amyloid-beta polypeptide 42") + + + + + + + pubmed:24590577 + + a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases path(MESH:"Sjogren's Syndrome") + + + + + + + pubmed:24590577 + + a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") causesNoChange p(HGNC:APP) + + + + + + + pubmed:18986241 + + a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases path(MESH:"Cognitive Dysfunction") + + + + + + + pubmed:18986241 + + a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") increases act(p(MGI:Chrm1)) + + + + + + + pubmed:18986241 + + a(MESH:"(S)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro(4.5)decan-3-one") decreases act(p(MGI:Gsk3b)) + + + + + + + pubmed:24401760 + + act(p(MGI:Bace1)) increases a(CHEBI:amyloid-beta) + + + + + + + pubmed:24590577 + + complex(p(HGNC:BACE1), p(HGNC:CHRM1)) increases deg(p(HGNC:BACE1)) + + + + + + + pubmed:24590577 + + bp(GO:"Wnt signaling pathway") decreases path(CONSO:neurotoxicity) + + + + + + + pubmed:23454242 + + bp(GO:"Wnt signaling pathway") association p(FPLX:PPP2) + + + + + + + pubmed:18494933 + + bp(GO:"Wnt signaling pathway") increases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:18494933 + + bp(GO:"Wnt signaling pathway") negativeCorrelation act(p(HGNC:GSK3B)) + + + + + + + pubmed:24590577 + + a(MESH:cevimeline) increases act(p(HGNC:CHRM1)) + + + + + + + pubmed:24590577 + + a(MESH:"1-((4-cyano-4-(pyridine-2-yl)piperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid") increases act(p(MGI:Chrm1)) + + + + + + + pubmed:24590577 + + a(MESH:"1-((4-cyano-4-(pyridine-2-yl)piperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid") increases bp(GO:memory) + + + + + + + pubmed:24590577 + + a(MESH:"1-((4-cyano-4-(pyridine-2-yl)piperidin-1-yl)methyl)-4-oxo-4H-quinolizine-3-carboxylic acid") increases path(MESH:"Executive Function") + + + + + + + pubmed:24590577 + + complex(p(FPLX:"G_protein"), p(HGNC:CHRM1)) increases p(CONSO:sAPP-alpha) + + + + + + + pubmed:24590577 + + complex(p(FPLX:"G_protein"), p(HGNC:CHRM1)) decreases a(CHEBI:amyloid-beta) + + + + + + + pubmed:24590577 + + complex(p(FPLX:"G_protein"), p(HGNC:CHRM1)) increases bp(GO:"signal transduction") + + + + + + + pubmed:24590577 + + a(CHEBI:cevimeline) decreases a(CHEBI:"amyloid-beta polypeptide 42") + + + + + + + pubmed:24590577 + + a(CHEBI:cevimeline) decreases path(MESH:"Sjogren's Syndrome") + + + + + + + pubmed:24590577 + + a(CHEBI:cevimeline) causesNoChange p(HGNC:APP) + + + + + + + pubmed:24590577 + + a(CHEBI:cevimeline) decreases a(CHEBI:amyloid-beta) + + + + + + + pubmed:24590577 + + a(CHEBI:cevimeline) causesNoChange p(CONSO:sAPP-alpha) + + + + + + + pubmed:24590577 + + a(CHEBI:cevimeline) increases path(MESH:Confusion) + + + + + + + pubmed:24590577 + + a(CHEBI:cevimeline) increases path(MESH:Diarrhea) + + + + + + + pubmed:24590577 + + a(CHEBI:cevimeline) increases path(MESH:Asthenia) + + + + + + + pubmed:24590577 + + a(CHEBI:cevimeline) increases path(MESH:"Gastrointestinal Diseases") + + + + + + + pubmed:24590577 + + a(MESH:"talsaclidine fumarate") increases p(CONSO:sAPP-alpha) + + + + + + + pubmed:24590577 + + a(MESH:"talsaclidine fumarate") decreases a(CHEBI:amyloid-beta) + + + + + + + pubmed:24590577 + + a(MESH:"talsaclidine fumarate") increases path(MESH:Sweating) + + + + + + + pubmed:24590577 + + a(MESH:"talsaclidine fumarate") increases path(MESH:Salivation) + + + + + + + pubmed:24590577 + + a(MESH:"WAY 132983") increases bp(GO:cognition) + + + + + + + pubmed:24590577 + + a(MESH:"WAY 132983") increases path(MESH:Salivation) + + + + + + + pubmed:24590577 + + a(MESH:"WAY 132983") increases path(MESH:Hypothermia) + + + + + + + pubmed:24590577 + + a(CONSO:VU0029767) increases complex(a(CHEBI:acetylcholine), p(HGNC:CHRM1)) + + + + + + + pubmed:24590577 + + a(CONSO:VU0090157) increases complex(a(CHEBI:acetylcholine), p(HGNC:CHRM1)) + + + + + + + pubmed:24590577 + + a(CONSO:VU0184670) increases act(p(HGNC:CHRM1)) + + + + + + + pubmed:24590577 + + a(CONSO:VU0184670) causesNoChange act(p(HGNC:CHRM2)) + + + + + + + pubmed:24590577 + + a(CONSO:VU0184670) causesNoChange act(p(HGNC:CHRM5)) + + + + + + + pubmed:24590577 + + a(CONSO:VU0184670) increases bp(GO:"NMDA selective glutamate receptor signaling pathway") + + + + + + + pubmed:29428175 + + path(MESH:"Substance-Related Disorders") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + + + + + + + pubmed:29428175 + + composite(a(CHEBI:"calcium ion"), p(HGNC:CHRNA7)) regulates tloc(a(CHEBI:neurotransmitter), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:29428175 + + composite(a(CHEBI:"calcium ion"), p(HGNC:CHRNA7)) regulates tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:29428175 + + composite(a(CHEBI:"calcium ion"), p(HGNC:CHRNA7)) regulates tloc(a(DRUGBANK:Norepinephrine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:29428175 + + composite(a(CHEBI:"calcium ion"), p(HGNC:CHRNA7)) regulates tloc(a(CHEBI:"gamma-aminobutyric acid"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:29428175 + + composite(a(CHEBI:"calcium ion"), p(HGNC:CHRNA7)) regulates bp(GO:"glutamate secretion") + + + + + + + pubmed:29428175 + + composite(a(CHEBI:"calcium ion"), p(HGNC:CHRNA7)) positiveCorrelation bp(GO:"regulation of presynaptic membrane potential") + + + + + + + pubmed:29428175 + + bp(GO:"glutamate secretion") positiveCorrelation act(p(HGNC:CHRNA7)) + + + + + + + pubmed:29428175 + + bp(GO:"glutamate secretion") positiveCorrelation bp(MESH:"Long-Term Potentiation") + + + + + + + pubmed:29428175 + + bp(GO:"regulation of presynaptic membrane potential") positiveCorrelation composite(a(CHEBI:"calcium ion"), p(HGNC:CHRNA7)) + + + + + + + pubmed:29428175 + + bp(GO:"regulation of presynaptic membrane potential") negativeCorrelation p(CONSO:alpha-Bungarotoxin) + + + + + + + pubmed:29428175 + + bp(MESH:"Calcium Signaling") increases bp(GO:"glutamate secretion") + + + + + + + pubmed:29428175 + + bp(MESH:"Calcium Signaling") increases tloc(a(MESH:"Synaptic Vesicles"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:29428175 + + bp(MESH:"Calcium Signaling") increases act(p(HGNC:CHRNA7), ma(GO:"calcium-induced calcium release activity")) + + + + + + + pubmed:29428175 + + bp(MESH:"Calcium Signaling") increases act(p(HGNC:CHRNA7), ma(GO:"calcium-induced calcium release activity")) + + + + + + + pubmed:29428175 + + bp(MESH:"Calcium Signaling") regulates bp(GO:"neuronal signal transduction") + + + + + + + pubmed:29428175 + + bp(MESH:"Calcium Signaling") regulates act(complex(GO:"protein kinase complex")) + + + + + + + pubmed:29428175 + + bp(MESH:"Calcium Signaling") regulates bp(GO:"gene expression") + + + + + + + pubmed:29428175 + + bp(MESH:"Calcium Signaling") positiveCorrelation p(HGNC:CAMK2B) + + + + + + + pubmed:29428175 + + bp(MESH:"Calcium Signaling") association p(HGNC:CAMK2B) + + + + + + + pubmed:29428175 + + bp(MESH:"Calcium Signaling") association bp(GO:"positive regulation of cAMP-dependent protein kinase activity") + + + + + + + pubmed:29428175 + + bp(MESH:"Calcium Signaling") increases p(HGNC:CREBZF) + + + + + + + pubmed:29428175 + + tloc(a(MESH:"Synaptic Vesicles"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) increases bp(MESH:"Neuronal Plasticity") + + + + + + + pubmed:30027901 + + a(MESH:"Synaptic Vesicles") association p(HGNC:HTT) + + + + + + + pubmed:29428175 + + bp(GO:"calcium ion import across plasma membrane") increases bp(MESH:"Calcium Signaling") + + + + + + + pubmed:29428175 + + bp(GO:"calcium ion import across plasma membrane") increases bp(MESH:"Calcium Signaling") + + + + + + + pubmed:29428175 + + p(HGNC:CHRNA7, var("p.Asp44Ala")) decreases bp(GO:"calcium ion import across plasma membrane") + + + + + + + pubmed:29428175 + + p(HGNC:CHRNA7, var("p.Asp44Ala")) decreases complex(a(CHEBI:choline), p(HGNC:CHRNA7)) + + + + + + + pubmed:29428175 + + p(HGNC:CHRNA7, var("p.Asp44Ala")) decreases act(p(HGNC:CHRNA7), ma(GO:"calcium-induced calcium release activity")) + + + + + + + pubmed:29428175 + + p(HGNC:CHRNA7, var("p.Asp44Ala")) decreases bp(GO:"neuron projection development") + + + + + + + pubmed:29428175 + + complex(a(CHEBI:choline), p(HGNC:CHRNA7)) increases act(p(HGNC:CHRNA7), ma(GO:"calcium-induced calcium release activity")) + + + + + + + pubmed:29428175 + + complex(a(CHEBI:choline), p(HGNC:CHRNA7)) increases act(p(HGNC:CHRNA7)) + + + + + + + pubmed:29428175 + + complex(a(CHEBI:choline), p(HGNC:CHRNA7)) increases bp(GO:"activation of phospholipase C activity") + + + + + + + pubmed:29428175 + + a(DRUGBANK:Dantrolene) decreases p(HGNCGENEFAMILY:"Ryanodine receptors") + + + + + + + pubmed:29428175 + + a(DRUGBANK:Dantrolene) decreases act(p(HGNC:CHRNA7), ma(GO:"calcium-induced calcium release activity")) + + + + + + + pubmed:21482353 + + bp(GO:"neuron maturation") positiveCorrelation p(HGNC:LYNX1) + + + + + + + pubmed:29428175 + + a(CHEBI:calcineurin) regulates a(GO:cytoskeleton) + + + + + + + pubmed:29428175 + + p(MESH:"Inositol 1,4,5-Trisphosphate Receptors") increases a(CHEBI:"calcium ion", loc(MESH:"Intracellular Space")) + + + + + + + pubmed:29428175 + + p(MESH:"Inositol 1,4,5-Trisphosphate Receptors") increases bp(GO:"regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity") + + + + + + + pubmed:29428175 + + a(CHEBI:"xestospongin C") decreases act(p(HGNC:CHRNA7), ma(GO:"calcium-induced calcium release activity")) + + + + + + + pubmed:29428175 + + a(MESH:Phospholipids) association bp(GO:"regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity") + + + + + + + pubmed:29428175 + + bp(GO:"positive regulation of cAMP-dependent protein kinase activity") association bp(MESH:"Calcium Signaling") + + + + + + + pubmed:29428175 + + bp(GO:"positive regulation of cAMP-dependent protein kinase activity") regulates p(MESH:"Ion Channels") + + + + + + + pubmed:29428175 + + bp(GO:"positive regulation of cAMP-dependent protein kinase activity") regulates p(MESH:"Cytoskeletal Proteins") + + + + + + + pubmed:29428175 + + bp(GO:"positive regulation of cAMP-dependent protein kinase activity") regulates p(HGNC:CHRNA7) + + + + + + + pubmed:29428175 + + bp(GO:"positive regulation of cAMP-dependent protein kinase activity") increases tloc(a(CHEBI:"L-glutamate(1-)", loc(MESH:"Presynaptic Terminals")), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:19491104 + + bp(GO:"vesicle-mediated transport") positiveCorrelation act(complex(GO:"kinesin complex")) + + + + + + + pubmed:29428175 + + act(p(HGNC:ADCY1)) increases bp(GO:"positive regulation of cAMP-dependent protein kinase activity") + + + + + + + pubmed:26979166 + + act(p(HGNC:ADCY1)) directlyIncreases a(MESH:"Cyclic AMP") + + + + + + + pubmed:26979166 + + act(p(HGNC:ADCY1)) directlyIncreases a(MESH:"Cyclic AMP") + + + + + + + + + pubmed:29428175 + + p(HGNC:CREBZF) increases bp(GO:"learning or memory") + + + + + + + pubmed:27299292 + + p(HGNC:CREBZF) increases p(HGNC:TFEB) + + + + + + + pubmed:27299292 + + p(HGNC:CREBZF) regulates act(p(HGNC:TFEB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) + + + + + + + pubmed:29428175 + + a(CHEBI:"cholinergic agonist") regulates act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + + + + + + + pubmed:29428175 + + a(CHEBI:"cholinergic agonist") association bp(MESH:"Immunity, Cellular") + + + + + + + pubmed:29428175 + + a(CHEBI:"cholinergic agonist") association path(MESH:"Immune System Diseases") + + + + + + + pubmed:29428175 + + a(CHEBI:"cholinergic agonist") association path(MESH:Inflammation) + + + + + + + pubmed:29428175 + + bp(MESH:"Immunity, Cellular") association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + + + + + + + pubmed:29428175 + + bp(MESH:"Immunity, Cellular") association a(CHEBI:"cholinergic agonist") + + + + + + + pubmed:26979166 + + bp(MESH:"Immunity, Cellular") increases p(HGNC:CHRNA7) + + + + + + + pubmed:30988501 + + bp(MESH:"Immunity, Cellular") association bp(GO:cognition) + + + + + + + pubmed:30988501 + + bp(MESH:"Immunity, Cellular") association bp(GO:cognition) + + + + + + + pubmed:30988501 + + bp(MESH:"Immunity, Cellular") association path(MESH:"Mood Disorders") + + + + + + + pubmed:30988501 + + bp(MESH:"Immunity, Cellular") association path(MESH:"Social Behavior") + + + + + + + pubmed:30988501 + + bp(MESH:"Immunity, Cellular") association path(MESH:"Illness Behavior") + + + + + + + pubmed:30988501 + + bp(MESH:"Immunity, Cellular") increases path(HP:Autoimmunity) + + + + + + + pubmed:29428175 + + path(MESH:"Immune System Diseases") association act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + + + + + + + pubmed:29428175 + + path(MESH:"Immune System Diseases") association a(CHEBI:"cholinergic agonist") + + + + + + + pubmed:23702978 + + path(MESH:"Immune System Diseases") increases path(MESH:Atherosclerosis) + + + + + + + pubmed:23702978 + + path(MESH:"Immune System Diseases") increases path(MESH:"Diabetes Mellitus, Type 2") + + + + + + + pubmed:23702978 + + path(MESH:"Immune System Diseases") increases path(MESH:"Neurodegenerative Diseases") + + + + + + + pubmed:29428175 + + a(CHEBI:"cholinergic antagonist") decreases p(HGNC:CHRNA7) + + + + + + + pubmed:29428175 + + a(CHEBI:"cholinergic antagonist") decreases p(HGNC:TNF) + + + + + + + pubmed:27314526 + + bp(GO:"cytokine secretion") increases bp(GO:"inflammatory response") + + + + + + + pubmed:30988501 + + bp(GO:"cytokine secretion") association act(a(MESH:"Central Nervous System")) + + + + + + + pubmed:29428175 + + complex(a(CHEBI:nicotine), p(HGNC:CHRNA4)) increases complex(p(HGNC:CHRNA4), p(HGNCGENEFAMILY:"G protein subunits alpha, group i")) + + + + + + + pubmed:29428175 + + complex(p(HGNC:CHRNA4), p(HGNCGENEFAMILY:"G protein subunits alpha, group i")) increases bp(GO:"cytokine secretion") + + + + + + + pubmed:29428175 + + complex(p(HGNC:CHRNA4), p(HGNCGENEFAMILY:"G protein subunits alpha, group i")) increases bp(GO:"T cell proliferation") + + + + + + + pubmed:29428175 + + complex(p(HGNC:CHRNA4), p(HGNCGENEFAMILY:"G protein subunits alpha, group i")) association p(HGNC:CDC42) + + + + + + + + + + + pubmed:29428175 + + p(HGNC:CDC42) association complex(p(HGNC:CHRNA4), p(HGNCGENEFAMILY:"G protein subunits alpha, group i")) + + + + + + + pubmed:29428175 + + act(p(HGNC:CDC42), ma(GO:"GTPase activity")) regulates bp(MESH:"Cell Movement") + + + + + + + pubmed:29428175 + + bp(GO:"ion channel modulating, G protein-coupled receptor signaling pathway") regulates bp(GO:"calcium ion homeostasis") + + + + + + + pubmed:29428175 + + bp(GO:"ion channel modulating, G protein-coupled receptor signaling pathway") regulates bp(GO:"store-operated calcium entry") + + + + + + + pubmed:29428175 + + bp(GO:"ion channel modulating, G protein-coupled receptor signaling pathway") regulates bp(GO:"regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity") + + + + + + + pubmed:29428175 + + bp(GO:"store-operated calcium entry") regulates bp(GO:"calcium ion homeostasis") + + + + + + + pubmed:29428175 + + complex(p(HGNC:CHRNA7), p(HGNCGENEFAMILY:"G protein subunits alpha, group i")) increases tloc(a(CHEBI:"calcium(2+)", loc(MESH:"Endoplasmic Reticulum")), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:29428175 + + a(PUBCHEM:9795278) increases act(p(HGNC:CHRNA7)) + + + + + + + pubmed:29428175 + + complex(p(HGNC:CHRNA7), p(HGNCGENEFAMILY:"G protein subunits alpha, group q")) increases bp(GO:"activation of phospholipase C activity") + + + + + + + pubmed:29428175 + + complex(p(HGNC:CHRNA7), p(HGNCGENEFAMILY:"G protein subunits alpha, group q")) increases bp(GO:"regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity") + + + + + + + + + + + + + + + pubmed:29428175 + + bp(GO:"activation of phospholipase C activity") increases bp(GO:"regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity") + + + + + + + pubmed:29428175 + + complex(complex(GO:"SNARE complex"), p(HGNCGENEFAMILY:"G protein subunits beta"), p(HGNCGENEFAMILY:"G protein subunits gamma")) regulates bp(GO:"neurotransmitter secretion") + + + + + + + + + pubmed:29758300 + + tloc(complex(GO:"SNARE complex"), fromLoc(GO:"extracellular space"), toLoc(GO:intracellular)) increases deg(a(CONSO:"Tau aggregates")) + + + + + + + + + pubmed:26088141 + + p(HGNCGENEFAMILY:"G protein subunits beta") increases complex(p(FPLX:"G_protein"), p(HGNC:CHRNA7)) + + + + + + + + + + + pubmed:29428175 + + complex(p(HGNC:CHRNA7), p(PUBCHEM:9795278)) increases bp(GO:"activation of phospholipase C activity") + + + + + + + pubmed:29428175 + + complex(p(HGNC:CHRNA7), p(PUBCHEM:9795278)) increases act(p(HGNC:CHRNA7)) + + + + + + + + + + + pubmed:29428175 + + complex(a(CHEBI:nicotine), p(HGNC:CHRNA7), p(HGNCGENEFAMILY:"G protein subunits alpha, group q")) increases bp(GO:"regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity") + + + + + + + pubmed:29428175 + + complex(a(CHEBI:choline), p(HGNC:CHRNA7), p(HGNCGENEFAMILY:"G protein subunits alpha, group q")) increases bp(GO:"regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity") + + + + + + + pubmed:29428175 + + complex(p(HGNC:CHRNA7), p(HGNCGENEFAMILY:"G protein subunits alpha, group q"), p(PUBCHEM:9795278)) increases bp(GO:"regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity") + + + + + + + pubmed:29428175 + + p(GO:spectrin) increases bp(GO:"cytoskeleton organization") + + + + + + + pubmed:29428175 + + composite(p(HGNC:CHRNA7), p(HGNC:GPRIN1)) increases p(HGNC:CHRNA7, loc(MESH:"Growth Cones")) + + + + + + + + + pubmed:29428175 + + complex(complex(GO:"heterotrimeric G-protein complex"), p(HGNC:CHRNA7)) increases act(p(HGNC:RHOA), ma(GO:"GTPase activity")) + + + + + + + pubmed:29428175 + + complex(complex(GO:"heterotrimeric G-protein complex"), p(HGNC:CHRNA7)) association path(MESH:"Behavior, Addictive") + + + + + + + + + pubmed:29428175 + + act(p(HGNC:RHOA), ma(GO:"GTPase activity")) increases a(GO:"actin cytoskeleton", loc(MESH:Synapses)) + + + + + + + pubmed:29428175 + + act(p(HGNC:RHOA), ma(GO:"GTPase activity")) increases a(MESH:Cytoskeleton, loc(MESH:Synapses)) + + + + + + + pubmed:27796283 + + act(p(HGNC:RHOA)) regulates bp(GO:"dendritic spine development") + + + + + + + pubmed:27796283 + + act(p(HGNC:RHOA)) association act(p(HGNC:ARHGEF2)) + + + + + + + pubmed:27796283 + + act(p(HGNC:RHOA)) negativeCorrelation a(MESH:"Dendritic Spines") + + + + + + + pubmed:27796283 + + act(p(HGNC:RHOA)) regulates a(MESH:"Dendritic Spines") + + + + + + + pubmed:27796283 + + act(p(HGNC:RHOA)) negativeCorrelation act(a(GO:synapse)) + + + + + + + + + pubmed:27796283 + + act(p(HGNC:RHOA)) positiveCorrelation complex(p(HGNC:ARHGEF2), p(HGNC:RHOA)) + + + + + + + pubmed:28901280 + + bp(MESH:"Cell Movement") association a(MESH:Acetylcholine) + + + + + + + pubmed:29428175 + + g(HGNC:RHOA, var("?")) positiveCorrelation path(MESH:Smoking) + + + + + + + pubmed:29428175 + + g(HGNC:RHOA, var("?")) positiveCorrelation path(MESH:"Tobacco Use Disorder") + + + + + + + + + pubmed:26979166 + + bp(GO:"membrane hyperpolarization") increases a(CHEBI:"calcium ion", loc(GO:nucleus)) + + + + + + + pubmed:26979166 + + a(MESH:"Cyclic AMP") directlyIncreases act(p(HGNC:PRKACA)) + + + + + + + pubmed:26979166 + + a(MESH:"Cyclic AMP") directlyIncreases act(p(HGNC:PRKACA)) + + + + + + + pubmed:26979166 + + bp(GO:"protein kinase A signaling") directlyIncreases p(HGNC:CREB1) + + + + + + + pubmed:26979166 + + bp(GO:"protein kinase A signaling") directlyDecreases p(HGNC:GSK3B) + + + + + + + pubmed:26979166 + + act(p(HGNC:TLR9)) increases r(MESH:Cytokines) + + + + + + + pubmed:26979166 + + p(MESH:Cytokines) increases path(MESH:Inflammation) + + + + + + + pubmed:26979166 + + p(FPLX:"PI3K_p85", pmod(go:0006468 ! "protein phosphorylation", Tyr)) directlyIncreases act(p(HGNC:AKT1)) + + + + + + + + + pubmed:26979166 + + act(p(MESH:"NF-kappa B")) increases path(MESH:Inflammation) + + + + + + + pubmed:26979166 + + act(p(HGNC:GABPA)) decreases path(MESH:"Oxidative Stress") + + + + + + + pubmed:26979166 + + act(p(HGNC:GABPA)) decreases path(MESH:Inflammation) + + + + + + + pubmed:26979166 + + act(p(MESH:"Receptors, Glucocorticoid")) increases p(HGNC:CHRNA7) + + + + + + + pubmed:26979166 + + a(PUBCHEM:311434) decreases p(HGNC:TNF) + + + + + + + pubmed:26979166 + + a(PUBCHEM:311434) decreases p(HGNC:IL6) + + + + + + + pubmed:26979166 + + a(PUBCHEM:311434) decreases path(MESH:Inflammation) + + + + + + + pubmed:26979166 + + composite(p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:RIC3)) increases complex(p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7)) + + + + + + + pubmed:26979166 + + composite(p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:SLURP1)) increases complex(p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7)) + + + + + + + + + pubmed:26979166 + + p(HGNC:SLURP1) increases act(complex(p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7))) + + + + + + + pubmed:26979166 + + composite(p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:LYNX1)) increases complex(p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7)) + + + + + + + + + pubmed:26979166 + + p(HGNC:LYNX1) increases act(complex(p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7))) + + + + + + + + + pubmed:21482353 + + p(HGNC:LYNX1) regulates act(p(FPLX:CHRN)) + + + + + + + pubmed:21482353 + + p(HGNC:LYNX1) decreases act(p(FPLX:CHRN)) + + + + + + + pubmed:21482353 + + p(HGNC:LYNX1) decreases act(p(FPLX:CHRN)) + + + + + + + pubmed:21482353 + + p(HGNC:LYNX1) regulates act(p(FPLX:CHRN)) + + + + + + + + + + + + + + + pubmed:21482353 + + p(HGNC:LYNX1) decreases bp(GO:"synaptic transmission, cholinergic") + + + + + + + pubmed:21482353 + + p(HGNC:LYNX1) association bp(GO:"synaptic transmission, cholinergic") + + + + + + + pubmed:21482353 + + p(HGNC:LYNX1) association path(MESH:"Cognitive Dysfunction") + + + + + + + pubmed:21482353 + + p(HGNC:LYNX1) positiveCorrelation bp(GO:"neuron maturation") + + + + + + + pubmed:21482353 + + p(HGNC:LYNX1) negativeCorrelation bp(GO:"synapse maturation") + + + + + + + pubmed:21482353 + + p(HGNC:LYNX1) regulates bp(GO:"generation of neurons") + + + + + + + pubmed:28901280 + + p(HGNC:LYNX1) decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) + + + + + + + pubmed:28901280 + + p(HGNC:LYNX1) decreases act(p(HGNC:CHRNA7)) + + + + + + + pubmed:26979166 + + composite(p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:EPHB2)) increases complex(p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7)) + + + + + + + + + pubmed:26979166 + + p(HGNC:EPHB2) increases act(complex(p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7))) + + + + + + + pubmed:26979166 + + composite(p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:PICK1)) increases complex(p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7)) + + + + + + + + + pubmed:26979166 + + p(HGNC:PICK1) increases act(complex(p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7), p(HGNC:CHRNA7))) + + + + + + + pubmed:26979166 + + p(MESH:"Protein-Tyrosine Kinases") increases p(HGNC:CHRNA7, pmod(go:0006468 ! "protein phosphorylation", Tyr)) + + + + + + + pubmed:26979166 + + p(MESH:"Protein-Tyrosine Kinases") decreases p(HGNC:CHRNA7, loc(MESH:"Cell Membrane")) + + + + + + + pubmed:26979166 + + p(HGNC:CHRNA7, pmod(go:0006468 ! "protein phosphorylation", Tyr)) decreases act(p(HGNC:CHRNA7)) + + + + + + + pubmed:22040696 + + p(HGNC:CHRNA7, pmod(go:0006468 ! "protein phosphorylation", Tyr)) decreases act(p(HGNC:CHRNA7)) + + + + + + + pubmed:26979166 + + a(CHEBI:Genisteine) decreases p(MESH:"Protein-Tyrosine Kinases") + + + + + + + pubmed:26979166 + + a(CHEBI:Genisteine) increases act(p(HGNC:CHRNA7)) + + + + + + + pubmed:26979166 + + a(CHEBI:Genisteine) increases p(HGNC:CHRNA7, loc(MESH:"Cell Membrane")) + + + + + + + pubmed:26979166 + + p(HGNC:CHRNA7, pmod(go:0006468 ! "protein phosphorylation", Ser)) regulates act(p(HGNC:CHRNA7)) + + + + + + + pubmed:26979166 + + act(p(HGNC:DRD5)) decreases act(p(HGNC:CHRNA7)) + + + + + + + pubmed:26979166 + + act(p(HGNC:DRD5)) increases act(p(HGNC:PRKACA)) + + + + + + + pubmed:26979166 + + p(HGNC:CHRNA7, pmod(go:0006468 ! "protein phosphorylation", Ser, 365)) decreases act(p(HGNC:CHRNA7)) + + + + + + + pubmed:26979166 + + path(MESH:"Stress, Physiological") increases path(DOID:"mental depression") + + + + + + + pubmed:26979166 + + path(MESH:"Stress, Physiological") increases a(MESH:"Immune System") + + + + + + + pubmed:30108137 + + path(MESH:"Stress, Physiological") association act(p(HGNC:TFEB)) + + + + + + + pubmed:30837838 + + path(MESH:"Stress, Physiological") increases p(CONSO:"TDP-43 aggregates", pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:30837838 + + path(MESH:"Stress, Physiological") increases p(CONSO:"TDP-43 aggregates", pmod(go:0016567 ! "protein ubiquitination")) + + + + + + + pubmed:26979166 + + act(a(PUBCHEM:135402045)) increases a(CHEBI:dopamine) + + + + + + + pubmed:26979166 + + act(a(PUBCHEM:135402045)) increases a(CHEBI:noradrenaline) + + + + + + + pubmed:26979166 + + act(a(PUBCHEM:135402045)) increases a(CHEBI:serotonin) + + + + + + + pubmed:26979166 + + act(a(PUBCHEM:135402045)) increases bp(GO:"microglial cell activation") + + + + + + + pubmed:26979166 + + a(CHEBI:monoamine) decreases path(HP:Anhedonia) + + + + + + + pubmed:26979166 + + a(CHEBI:monoamine) positiveCorrelation path(MESH:Affect) + + + + + + + pubmed:26979166 + + composite(a(CHEBI:"calcium(2+)"), p(HGNC:ADCY1)) increases act(p(HGNC:ADCY1)) + + + + + + + + + pubmed:26979166 + + complex(p(HGNC:CREB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 133)), p(HGNC:GSK3B)) increases deg(p(HGNC:CREB1)) + + + + + + + pubmed:26979166 + + complex(p(HGNC:CREB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 133)), p(HGNC:GSK3B)) decreases act(p(HGNC:CREB1)) + + + + + + + pubmed:26979166 + + complex(p(HGNC:CREBBP), p(MESH:"NF-kappa B")) decreases complex(p(HGNC:CREB1), p(HGNC:CREBBP)) + + + + + + + pubmed:26979166 + + complex(p(HGNC:CREBBP), p(MESH:"NF-kappa B")) decreases act(p(MESH:"NF-kappa B")) + + + + + + + pubmed:26979166 + + complex(p(HGNC:CREB1), p(HGNC:CREBBP)) decreases complex(p(HGNC:CREBBP), p(MESH:"NF-kappa B")) + + + + + + + pubmed:26979166 + + a(PUBCHEM:11173546) decreases act(p(HGNC:CHRNA7)) + + + + + + + pubmed:26979166 + + a(PUBCHEM:11173546) increases act(p(HGNC:PRKACA)) + + + + + + + pubmed:26979166 + + a(PUBCHEM:11173546) increases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) + + + + + + + pubmed:26979166 + + a(PUBCHEM:11173546) increases p(HGNC:CREB1, pmod(go:0006468 ! "protein phosphorylation", Ser, 133)) + + + + + + + pubmed:26979166 + + path(HP:Psychosis) association bp(GO:"microglial cell activation") + + + + + + + pubmed:26979166 + + path(HP:Psychosis) increases a(MESH:Cytokines) + + + + + + + pubmed:26979166 + + path(HP:Psychosis) increases deg(a(MESH:"White Matter")) + + + + + + + pubmed:26979166 + + deg(a(MESH:"White Matter")) positiveCorrelation path(DOID:schizophrenia) + + + + + + + pubmed:25514383 + + a(MESH:"White Matter") negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:26195256 + + a(MESH:"White Matter") association path(MESH:"Alzheimer Disease") + + + + + + + pubmed:24762290 + + a(MESH:"White Matter") positiveCorrelation complex(CONSO:"alpha-4 beta-2 nAChR") + + + + + + + pubmed:30012004 + + a(MESH:"White Matter") negativeCorrelation path(MESH:"Huntington Disease") + + + + + + + pubmed:26979166 + + a(CHEBI:prostaglandin) increases deg(a(MESH:"White Matter")) + + + + + + + pubmed:26979166 + + a(CHEBI:prostaglandin) increases deg(a(MESH:"Gray Matter")) + + + + + + + pubmed:26979166 + + p(HGNC:CHRFAM7A, var("?")) positiveCorrelation path(DOID:schizophrenia) + + + + + + + pubmed:26979166 + + p(HGNC:CHRFAM7A, var("?")) association path(DOID:"bipolar disorder") + + + + + + + pubmed:26979166 + + a(DRUGBANK:Encenicline) increases act(p(HGNC:CHRNA7)) + + + + + + + pubmed:26979166 + + a(DRUGBANK:Encenicline) increases bp(GO:cognition) + + + + + + + pubmed:26979166 + + a(DRUGBANK:Encenicline) decreases path(DOID:schizophrenia) + + + + + + + pubmed:26979166 + + a(CHEBI:tropisetron) increases act(p(HGNC:CHRNA7)) + + + + + + + pubmed:19721446 + + a(CHEBI:tropisetron) increases act(p(HGNC:CHRNA7)) + + + + + + + pubmed:26979166 + + a(CHEBI:tropisetron) decreases path(DOID:schizophrenia) + + + + + + + pubmed:19721446 + + a(CHEBI:tropisetron) decreases bp(MESH:"Sensory Gating") + + + + + + + pubmed:26979166 + + a(PUBCHEM:10380472) increases act(p(HGNC:CHRNA7)) + + + + + + + pubmed:26979166 + + a(PUBCHEM:10380472) decreases path(MESH:Depression) + + + + + + + pubmed:26979166 + + a(PUBCHEM:10380472) decreases path(DOID:schizophrenia) + + + + + + + pubmed:26979166 + + a(DRUGBANK:Galantamine) increases act(p(HGNC:CHRNA7)) + + + + + + + + + pubmed:26979166 + + a(DRUGBANK:Galantamine) causesNoChange path(DOID:schizophrenia) + + + + + + + pubmed:26979166 + + composite(a(DRUGBANK:Galantamine), a(PUBCHEM:305)) increases act(p(HGNC:CHRNA7)) + + + + + + + pubmed:26979166 + + composite(a(DRUGBANK:Galantamine), a(PUBCHEM:305)) causesNoChange path(DOID:schizophrenia) + + + + + + + pubmed:26979166 + + a(PUBCHEM:16755766) increases act(p(HGNC:CHRNA7)) + + + + + + + pubmed:26979166 + + a(PUBCHEM:16755766) causesNoChange path(DOID:schizophrenia) + + + + + + + pubmed:26979166 + + a(CHEBI:minocycline) decreases bp(GO:"microglial cell activation") + + + + + + + pubmed:26979166 + + a(CHEBI:minocycline) decreases path(DOID:schizophrenia) + + + + + + + pubmed:29626319 + + a(CHEBI:minocycline) increases deg(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:30988501 + + a(CHEBI:minocycline) decreases a(MESH:Microglia) + + + + + + + pubmed:30988501 + + a(CHEBI:minocycline) decreases path(DOID:"mental depression") + + + + + + + + + pubmed:30988501 + + a(CHEBI:minocycline) causesNoChange path(DOID:"autism spectrum disorder") + + + + + + + pubmed:26979166 + + path(NCIT:C78349) increases path(MESH:"Irritable Mood") + + + + + + + pubmed:26979166 + + path(NCIT:C78349) increases path(MESH:"Sleep Initiation and Maintenance Disorders") + + + + + + + pubmed:26979166 + + path(DOID:obesity) positiveCorrelation path(MESH:Depression) + + + + + + + pubmed:26979166 + + path(DOID:obesity) positiveCorrelation path(DOID:"bipolar disorder") + + + + + + + pubmed:30988501 + + path(DOID:obesity) association path(MESH:Inflammation) + + + + + + + pubmed:30988501 + + path(DOID:obesity) decreases act(a(MESH:Neurons)) + + + + + + + pubmed:26979166 + + path(DOID:"cardiovascular system disease") positiveCorrelation path(MESH:Depression) + + + + + + + pubmed:26979166 + + path(DOID:"cardiovascular system disease") positiveCorrelation path(DOID:"bipolar disorder") + + + + + + + pubmed:26979166 + + complex(a(CHEBI:dopamine), p(INTERPRO:"Dopamine D2 receptor")) increases complex(p(HGNC:AKT1), p(HGNC:ARRB1), p(HGNC:GSK3B), p(HGNC:PPP2R5B), p(INTERPRO:"Dopamine D2 receptor")) + + + + + + + + + + + pubmed:26979166 + + complex(p(HGNC:AKT1), p(HGNC:ARRB1), p(HGNC:GSK3B), p(HGNC:PPP2R5B), p(INTERPRO:"Dopamine D2 receptor")) increases act(p(HGNC:GSK3B)) + + + + + + + + + + + + + pubmed:23454242 + + p(HGNC:PPP2R5B) association a(MESH:Cytosol) + + + + + + + + + pubmed:21882945 + + p(HGNC:PPP2R5B) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:21882945 + + p(HGNC:PPP2R5B) increases complex(a(GO:microtubule), p(HGNC:MAPT)) + + + + + + + pubmed:26979166 + + path(HP:Autism) increases path(HP:Allergy) + + + + + + + pubmed:26979166 + + path(HP:Autism) increases path(MESH:Inflammation) + + + + + + + pubmed:26979166 + + path(HP:Autism) increases bp(GO:"mast cell activation") + + + + + + + pubmed:26979166 + + g(HGNC:MECP2, var("?")) increases path(DOID:"Rett syndrome") + + + + + + + pubmed:26979166 + + g(HGNC:MECP2, var("?")) decreases p(HGNC:CHRNA7) + + + + + + + + + pubmed:26979166 + + path(DOID:"parasitic helminthiasis infectious disease") increases a(MESH:"Th2 Cells") + + + + + + + pubmed:26979166 + + p(MESH:Cholinesterases) positiveCorrelation path(DOID:dementia) + + + + + + + pubmed:26979166 + + bp(GO:"glial cell-derived neurotrophic factor receptor signaling pathway") increases bp(MESH:Apoptosis) + + + + + + + pubmed:26979166 + + complex(a(CHEBI:amyloid-beta), p(CONSO:"alpha-7 beta-2 nAChR")) decreases complex(a(PUBCHEM:305), p(CONSO:"alpha-7 beta-2 nAChR")) + + + + + + + + + + + pubmed:25514383 + + p(CONSO:"alpha-7 beta-2 nAChR") negativeCorrelation act(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:26979166 + + bp(GO:"microglial cell mediated cytotoxicity") negativeCorrelation bp(GO:aging) + + + + + + + pubmed:26979166 + + p(CONSO:"amyloid-beta oligomers", loc(GO:"extracellular space")) decreases complex(CONSO:"alpha-7 beta-2 nAChR", loc(MESH:"Cholinergic Neurons")) + + + + + + + pubmed:26979166 + + p(CONSO:"amyloid-beta oligomers", loc(GO:"extracellular space")) increases deg(complex(CONSO:"alpha-7 beta-2 nAChR", loc(MESH:"Cholinergic Neurons"))) + + + + + + + + + pubmed:26088141 + + p(HGNC:GNAS) increases complex(p(HGNC:CHRNA7), p(HGNC:GNAS)) + + + + + + + + + pubmed:26088141 + + p(HGNC:GNAI2) increases complex(p(HGNC:CHRNA7), p(HGNC:GNAI2)) + + + + + + + pubmed:26088141 + + composite(p(CONSO:alpha-Bungarotoxin), p(HGNC:CHRNA7), p(MESH:"Heterotrimeric GTP-Binding Proteins")) increases complex(p(CONSO:alpha-Bungarotoxin), p(MESH:"Heterotrimeric GTP-Binding Proteins")) + + + + + + + + + + + pubmed:26088141 + + p(CONSO:"GPBC, alpha-7 nAChR") orthologous p(CONSO:"GPBC, Glycine Receptor 1") + + + + + + + pubmed:26088141 + + p(CONSO:"GPBC, Glycine Receptor 1") orthologous p(CONSO:"GPBC, alpha-7 nAChR") + + + + + + + pubmed:26088141 + + p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) causesNoChange bp(CONSO:"nAChR assembly") + + + + + + + pubmed:26088141 + + p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) increases p(HGNC:CHRNA7) + + + + + + + + + pubmed:26088141 + + p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")), p(HGNC:GNAQ)) + + + + + + + pubmed:26088141 + + p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")), p(HGNC:GNAQ)) + + + + + + + pubmed:26088141 + + p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")), p(HGNC:GNAQ)) + + + + + + + pubmed:26088141 + + p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")), p(HGNC:GNAQ)) + + + + + + + + + pubmed:26088141 + + p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(FPLX:"G_beta"), p(FPLX:"G_gamma"), p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) + + + + + + + pubmed:26088141 + + p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(FPLX:"G_beta"), p(FPLX:"G_gamma"), p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) + + + + + + + pubmed:26088141 + + p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) directlyDecreases complex(p(FPLX:"G_beta"), p(FPLX:"G_gamma"), p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) + + + + + + + pubmed:26088141 + + p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) decreases act(a(CHEBI:choline)) + + + + + + + pubmed:26088141 + + p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) decreases a(CHEBI:"calcium(2+)") + + + + + + + pubmed:26088141 + + p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) decreases act(a(CHEBI:"calcium(2+)", loc(GO:intracellular))) + + + + + + + + + pubmed:26088141 + + p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) decreases bp(GO:"calcium-mediated signaling") + + + + + + + pubmed:26088141 + + p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) decreases bp(MESH:"Pleckstrin Homology Domains") + + + + + + + pubmed:26088141 + + p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) association bp(MESH:"Pleckstrin Homology Domains") + + + + + + + pubmed:26088141 + + g(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) causesNoChange p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) + + + + + + + + + + + + + + + pubmed:26088141 + + composite(a(CHEBI:choline), p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)") + + + + + + + pubmed:26088141 + + composite(a(CHEBI:choline), p(HGNC:CHRNA7)) increases a(CHEBI:"calcium(2+)") + + + + + + + pubmed:26088141 + + composite(a(CHEBI:choline), p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) decreases a(CHEBI:"calcium(2+)") + + + + + + + pubmed:26088141 + + composite(a(CHEBI:choline), p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) decreases a(CHEBI:"calcium(2+)") + + + + + + + pubmed:26088141 + + a(MESH:"GP Antagonist-2A peptide") causesNoChange a(CHEBI:"calcium(2+)") + + + + + + + pubmed:26088141 + + a(MESH:"GP Antagonist-2A peptide") causesNoChange act(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) + + + + + + + pubmed:26088141 + + a(MESH:"GP Antagonist-2A peptide") decreases bp(MESH:"Pleckstrin Homology Domains") + + + + + + + pubmed:26088141 + + a(MESH:Barium) causesNoChange bp(GO:"calcium-mediated signaling") + + + + + + + pubmed:26088141 + + a(MESH:Barium) causesNoChange act(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) + + + + + + + pubmed:26088141 + + a(MESH:Barium) causesNoChange act(p(HGNC:CHRNA7)) + + + + + + + pubmed:26088141 + + a(CHEBI:nifedipine) decreases act(a(CHEBI:choline)) + + + + + + + pubmed:26088141 + + a(CHEBI:nifedipine) decreases a(CHEBI:"calcium(2+)") + + + + + + + pubmed:26088141 + + a(CHEBI:nifedipine) increases bp(GO:"calcium-mediated signaling") + + + + + + + pubmed:26088141 + + a(CHEBI:nifedipine) causesNoChange bp(GO:"calcium-mediated signaling") + + + + + + + pubmed:26088141 + + a(CHEBI:nifedipine) causesNoChange act(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) + + + + + + + pubmed:26088141 + + bp(MESH:"Pleckstrin Homology Domains") association a(CHEBI:choline) + + + + + + + pubmed:26088141 + + bp(MESH:"Pleckstrin Homology Domains") association p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) + + + + + + + pubmed:26088141 + + a(MESH:"xestospongin C") decreases act(p(HGNC:CHRNA7)) + + + + + + + pubmed:26088141 + + a(MESH:"xestospongin C") decreases bp(GO:"calcium-mediated signaling") + + + + + + + pubmed:26088141 + + a(MESH:"xestospongin C") decreases act(p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A"))) + + + + + + + pubmed:25514383 + + a(HP:"cholinergic neuron") negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:25514383 + + a(HP:"cholinergic neuron") association bp(GO:cognition) + + + + + + + pubmed:25514383 + + a(HP:"cholinergic neuron") increases bp(GO:cognition) + + + + + + + pubmed:25514383 + + a(HP:"cholinergic neuron") association path(MESH:Attention) + + + + + + + + + + + + + pubmed:25514383 + + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"calcium ion transport") + + + + + + + pubmed:25514383 + + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") positiveCorrelation bp(GO:"calcium ion transport") + + + + + + + pubmed:28445721 + + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"calcium ion transport") + + + + + + + pubmed:21482353 + + act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) association bp(GO:"calcium ion transport") + + + + + + + pubmed:25514383 + + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") regulates tloc(a(CHEBI:neurotransmitter), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) + + + + + + + pubmed:25514383 + + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") regulates bp(GO:"second-messenger-mediated signaling") + + + + + + + pubmed:25514383 + + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") regulates bp(GO:"neuron cellular homeostasis") + + + + + + + pubmed:25514383 + + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") regulates bp(GO:"gene expression") + + + + + + + pubmed:25514383 + + act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases a(GO:"glutamatergic synapse") + + + + + + + + + + + + + pubmed:25514383 + + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + + + + + + + pubmed:25514383 + + act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) regulates tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + + + + + + + pubmed:25514383 + + act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases bp(GO:"positive regulation of synaptic plasticity") + + + + + + + pubmed:25514383 + + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"positive regulation of synaptic plasticity") + + + + + + + pubmed:25514383 + + act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases bp(GO:"intracellular signal transduction") + + + + + + + pubmed:25514383 + + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases p(FPLX:AKT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:25514383 + + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"ERK1 and ERK2 cascade") + + + + + + + pubmed:25514383 + + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") decreases bp(HP:Neurodegeneration) + + + + + + + pubmed:25514383 + + act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases bp(HP:Neurodegeneration) + + + + + + + pubmed:25514383 + + act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases bp(MESH:"Cell Survival") + + + + + + + pubmed:25514383 + + act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases a(GO:synapse) + + + + + + + pubmed:25514383 + + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases act(a(CHEBI:"pregnenolone sulfate")) + + + + + + + pubmed:25514383 + + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:cognition) + + + + + + + pubmed:25514383 + + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"synaptic transmission, glutamatergic") + + + + + + + pubmed:25514383 + + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases act(a(CHEBI:simvastatin)) + + + + + + + pubmed:25514383 + + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:memory) + + + + + + + pubmed:25514383 + + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") decreases bp(GO:"apoptotic process") + + + + + + + pubmed:28445721 + + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") association bp(MESH:"Physiological Phenomena") + + + + + + + pubmed:28445721 + + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") association path(MESH:Disease) + + + + + + + + + + + pubmed:21482353 + + act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) increases act(p(MGI:Lynx1)) + + + + + + + pubmed:21482353 + + act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) association bp(GO:"generation of neurons") + + + + + + + pubmed:21482353 + + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") regulates bp(GO:"sensory processing") + + + + + + + pubmed:21482353 + + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases bp(GO:"sensory processing") + + + + + + + pubmed:21482353 + + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") association a(HP:"inhibitory interneuron") + + + + + + + pubmed:21482353 + + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") increases a(HP:"inhibitory interneuron") + + + + + + + pubmed:21482353 + + a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") association path(MESH:Schizophrenia) + + + + + + + pubmed:28132910 + + act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) negativeCorrelation a(CONSO:B-973) + + + + + + + + + pubmed:30664622 + + a(GO:"glutamatergic synapse") association act(a(PUBCHEM:9832404)) + + + + + + + pubmed:30664622 + + a(GO:"glutamatergic synapse") association act(p(HGNC:ADNP)) + + + + + + + pubmed:27013968 + + act(a(GO:"glutamatergic synapse", loc(MESH:Thalamus))) increases bp(GO:"locomotory behavior") + + + + + + + pubmed:25514383 + + complex(a(CHEBI:amyloid-beta), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) decreases bp(HP:Neurodegeneration) + + + + + + + pubmed:25514383 + + complex(a(CHEBI:amyloid-beta), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) decreases a(CONSO:"amyloid-beta aggregates") + + + + + + + + + pubmed:25514383 + + p(HGNC:APP, frag("12_28")) increases complex(p(HGNC:APP, frag("12_28")), p(HGNC:CHRNA7)) + + + + + + + pubmed:25514383 + + complex(a(CHEBI:amyloid-beta), p(FPLX:CHRN)) increases bp(GO:"intracellular signal transduction") + + + + + + + pubmed:25514383 + + complex(a(CHEBI:amyloid-beta), p(FPLX:CHRN)) decreases bp(MESH:"Cell Survival") + + + + + + + pubmed:25514383 + + complex(a(CHEBI:amyloid-beta), p(FPLX:CHRN)) association bp(GO:"neuron cellular homeostasis") + + + + + + + pubmed:27522251 + + complex(a(CHEBI:amyloid-beta), p(FPLX:CHRN)) increases path(MESH:"Memory Disorders") + + + + + + + pubmed:25514383 + + a(PUBCHEM:637026) increases act(p(CONSO:"beta-2-containing nAChR")) + + + + + + + pubmed:25514383 + + a(CONSO:"amyloid-beta 40 oligomers") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + + + + + + + pubmed:25514383 + + composite(a(CHEBI:amyloid-beta), a(CHEBI:nicotine)) increases act(p(CONSO:"alpha-4 beta-2 nAChR")) + + + + + + + pubmed:28420982 + + bp(GO:"intracellular signal transduction") association p(HGNC:MAPT) + + + + + + + pubmed:25514383 + + p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Val717Phe")) decreases path(MESH:"Spatial Memory") + + + + + + + pubmed:18986241 + + path(MESH:"Cognition Disorders") negativeCorrelation p(HGNC:NTRK1) + + + + + + + pubmed:18986241 + + path(MESH:"Cognition Disorders") positiveCorrelation a(MESH:"pro-nerve growth factor, human") + + + + + + + pubmed:18986241 + + path(MESH:"Cognition Disorders") positiveCorrelation act(p(HGNC:MMP9)) + + + + + + + pubmed:28901280 + + path(MESH:"Cognition Disorders") association p(MESH:"Receptors, Nicotinic") + + + + + + + pubmed:25514383 + + a(CHEBI:"(-)-cotinine") increases path(MESH:Attention) + + + + + + + pubmed:30697142 + + a(CHEBI:"(-)-cotinine") increases path(MESH:Attention) + + + + + + + pubmed:25514383 + + a(CHEBI:"(-)-cotinine") increases bp(GO:memory) + + + + + + + pubmed:25514383 + + a(CHEBI:"(-)-cotinine") decreases path(MESH:"Plaque, Amyloid") + + + + + + + pubmed:30697142 + + a(CHEBI:"(-)-cotinine") decreases path(MESH:"Plaque, Amyloid") + + + + + + + pubmed:25514383 + + a(CHEBI:"(-)-cotinine") increases act(p(FPLX:AKT)) + + + + + + + pubmed:30697142 + + a(CHEBI:"(-)-cotinine") increases act(p(FPLX:AKT)) + + + + + + + pubmed:25514383 + + a(CHEBI:"(-)-cotinine") increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + + + + + + + pubmed:30697142 + + a(CHEBI:"(-)-cotinine") increases bp(GO:"learning or memory") + + + + + + + pubmed:30697142 + + a(CHEBI:"(-)-cotinine") positiveCorrelation bp(GO:"learning or memory") + + + + + + + pubmed:30697142 + + a(CHEBI:"(-)-cotinine") causesNoChange path(MESH:"Tobacco Use Disorder") + + + + + + + pubmed:30697142 + + a(CHEBI:"(-)-cotinine") causesNoChange path(MESH:"Tobacco Use Disorder") + + + + + + + + + pubmed:30697142 + + a(CHEBI:"(-)-cotinine") increases a(MESH:hydroxycotinine) + + + + + + + pubmed:30697142 + + a(CHEBI:"(-)-cotinine") increases a(CHEBI:"cotinine N-oxide") + + + + + + + pubmed:30697142 + + a(CHEBI:"(-)-cotinine") increases a(PUBCHEM:583) + + + + + + + pubmed:30697142 + + a(CHEBI:"(-)-cotinine") increases a(PUBCHEM:3398121) + + + + + + + pubmed:30697142 + + a(CHEBI:"(-)-cotinine") increases a(CHEBI:Norcotinine) + + + + + + + pubmed:30697142 + + a(CHEBI:"(-)-cotinine") causesNoChange path(MESH:Tachyphylaxis) + + + + + + + pubmed:30697142 + + a(CHEBI:"(-)-cotinine") causesNoChange path(MESH:"Substance Withdrawal Syndrome") + + + + + + + pubmed:30697142 + + a(CHEBI:"(-)-cotinine") causesNoChange path(MESH:"Cardiovascular Deconditioning") + + + + + + + pubmed:30697142 + + a(CHEBI:"(-)-cotinine") positiveCorrelation bp(GO:cognition) + + + + + + + + + + + pubmed:30697142 + + a(CHEBI:"(-)-cotinine") increases complex(CONSO:"alpha-4 beta-2 nAChR") + + + + + + + pubmed:30697142 + + a(CHEBI:"(-)-cotinine") increases tloc(complex(CONSO:"alpha-4 beta-2 nAChR"), fromLoc(MESH:Cytoplasm), toLoc(MESH:"Cell Membrane")) + + + + + + + pubmed:30697142 + + a(CHEBI:"(-)-cotinine") decreases complex(CONSO:"alpha-4 beta-2 nAChR") + + + + + + + pubmed:30697142 + + a(CHEBI:"(-)-cotinine") increases bp(MESH:Endocytosis) + + + + + + + pubmed:30697142 + + a(CHEBI:"(-)-cotinine") increases p(HGNC:DLG4) + + + + + + + pubmed:30697142 + + a(CHEBI:"(-)-cotinine") decreases a(CHEBI:"amyloid-beta polypeptide 42") + + + + + + + pubmed:30697142 + + a(CHEBI:"(-)-cotinine") decreases a(CONSO:"amyloid-beta 42 oligomers") + + + + + + + pubmed:30697142 + + a(CHEBI:"(-)-cotinine") decreases act(p(HGNC:GSK3B)) + + + + + + + + + + + pubmed:30697142 + + a(CHEBI:"(-)-cotinine") decreases a(CHEBI:"reactive oxygen species") + + + + + + + + + pubmed:30697142 + + a(CHEBI:"(-)-cotinine") decreases bp(MESH:"Lipid Peroxidation") + + + + + + + pubmed:30697142 + + a(CHEBI:"(-)-cotinine") isA a(CHEBI:antioxidant) + + + + + + + pubmed:28391535 + + a(CHEBI:"(-)-cotinine") isA a(CHEBI:lactam) + + + + + + + pubmed:28391535 + + a(CHEBI:"(-)-cotinine") association a(CHEBI:lactam) + + + + + + + pubmed:25514383 + + a(CONSO:"S 24795") decreases a(CHEBI:amyloid-beta) + + + + + + + pubmed:25514383 + + a(CONSO:"S 24795") increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + + + + + + + pubmed:25514383 + + a(CONSO:4-OH-GTS-21) increases path(MESH:"Spatial Memory") + + + + + + + pubmed:17640819 + + a(CONSO:4-OH-GTS-21) increases path(MESH:"Spatial Memory") + + + + + + + pubmed:25514383 + + a(CONSO:4-OH-GTS-21) causesNoChange bp(GO:"neuron cellular homeostasis") + + + + + + + pubmed:17640819 + + a(CONSO:4-OH-GTS-21) increases path(MESH:"Avoidance Learning") + + + + + + + pubmed:17640819 + + a(CONSO:4-OH-GTS-21) causesNoChange bp(GO:locomotion) + + + + + + + pubmed:17640819 + + a(CONSO:4-OH-GTS-21) increases a(GO:perikaryon) + + + + + + + pubmed:17640819 + + a(CONSO:4-OH-GTS-21) causesNoChange a(MESH:"Cholinergic Neurons") + + + + + + + pubmed:17640819 + + a(CONSO:4-OH-GTS-21) decreases a(MESH:"Cholinergic Neurons") + + + + + + + pubmed:17640819 + + a(CONSO:4-OH-GTS-21) causesNoChange a(MESH:"GABAergic Neurons") + + + + + + + pubmed:17640819 + + a(CONSO:4-OH-GTS-21) causesNoChange a(CHEBI:amyloid-beta) + + + + + + + pubmed:25514383 + + a(PUBCHEM:9928899) increases bp(GO:"long-term synaptic potentiation") + + + + + + + pubmed:25514383 + + a(CHEBI:"pregnenolone sulfate") increases bp(GO:cognition) + + + + + + + pubmed:25514383 + + a(CHEBI:"pregnenolone sulfate") increases bp(GO:"positive regulation of synaptic plasticity") + + + + + + + pubmed:25514383 + + a(CHEBI:"pregnenolone sulfate") increases bp(GO:"synaptic transmission, glutamatergic") + + + + + + + pubmed:25514383 + + a(CHEBI:"pregnenolone sulfate") increases path(MESH:"Spatial Memory") + + + + + + + pubmed:25514383 + + a(CHEBI:"pregnenolone sulfate") decreases bp(GO:"apoptotic process") + + + + + + + pubmed:25514383 + + a(CHEBI:simvastatin) regulates bp(GO:"cholesterol homeostasis") + + + + + + + pubmed:25514383 + + a(CHEBI:simvastatin) increases bp(GO:cognition) + + + + + + + + + pubmed:25514383 + + a(CHEBI:simvastatin) decreases bp(GO:"apoptotic process") + + + + + + + pubmed:29626319 + + a(CHEBI:simvastatin) increases deg(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:29626319 + + a(CHEBI:simvastatin) increases bp(GO:"ERK1 and ERK2 cascade") + + + + + + + pubmed:29626319 + + a(CHEBI:simvastatin) increases tloc(p(HGNC:MME), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:21718217 + + bp(GO:"cholesterol homeostasis") association p(HGNC:NR1H3) + + + + + + + pubmed:25514383 + + composite(a(CHEBI:simvastatin), p(MGI:App, frag("25_35"))) increases bp(GO:memory) + + + + + + + + + pubmed:25881725 + + p(MGI:App, frag("25_35")) decreases bp(GO:learning) + + + + + + + pubmed:25881725 + + p(MGI:App, frag("25_35")) decreases path(MESH:"Spatial Memory") + + + + + + + pubmed:25881725 + + p(MGI:App, frag("25_35")) increases a(CONSO:"amyloid-beta oligomers", loc(GO:"extracellular region")) + + + + + + + pubmed:25881725 + + p(MGI:App, frag("25_35")) causesNoChange r(MGI:Chrna7) + + + + + + + pubmed:25514383 + + complex(a(CHEBI:amyloid-beta), p(FPLX:CHRN), p(HGNC:FLNA)) increases bp(GO:"intracellular signal transduction") + + + + + + + + + + + pubmed:25514383 + + complex(p(HGNC:CHRNA7), p(HGNC:FLNA)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:25514383 + + a(CONSO:PTI-125) decreases complex(p(HGNC:CHRNA7), p(HGNC:FLNA)) + + + + + + + pubmed:25514383 + + a(CONSO:PTI-125) decreases complex(a(CHEBI:amyloid-beta), p(FPLX:CHRN)) + + + + + + + pubmed:25514383 + + a(CONSO:PTI-125) increases act(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:27522251 + + p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases path(MESH:"Memory Disorders") + + + + + + + pubmed:27522251 + + p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases path(MESH:"Memory Disorders") + + + + + + + pubmed:27522251 + + p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases path(MESH:"Memory Disorders") + + + + + + + pubmed:27522251 + + p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases bp(GO:locomotion) + + + + + + + pubmed:27522251 + + p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) causesNoChange path(MESH:Anxiety) + + + + + + + pubmed:27522251 + + p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) causesNoChange bp(GO:"microglial cell activation") + + + + + + + pubmed:27522251 + + p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) causesNoChange act(a(MESH:Neuroglia)) + + + + + + + pubmed:27522251 + + p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) causesNoChange bp(GO:"inflammatory response") + + + + + + + + + + + pubmed:27522251 + + p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases a(CONSO:CONSO00022) + + + + + + + pubmed:27522251 + + p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases a(CONSO:CONSO00022) + + + + + + + pubmed:27522251 + + p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases a(CONSO:CONSO00022) + + + + + + + pubmed:27522251 + + composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrnb2)) decreases path(MESH:"Memory Disorders") + + + + + + + pubmed:27522251 + + composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrnb2)) decreases path(MESH:"Memory Disorders") + + + + + + + pubmed:27522251 + + composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrnb2)) decreases a(CONSO:CONSO00022) + + + + + + + pubmed:27522251 + + complex(a(CHEBI:amyloid-beta), p(MGI:Chrnb2)) increases path(MESH:"Memory Disorders") + + + + + + + pubmed:27522251 + + composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrna7)) decreases path(MESH:"Memory Disorders") + + + + + + + pubmed:27522251 + + composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrna7)) decreases path(MESH:"Memory Disorders") + + + + + + + pubmed:27522251 + + composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrna7)) decreases path(MESH:"Cognitive Dysfunction") + + + + + + + pubmed:27522251 + + composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrna7)) decreases a(CONSO:CONSO00022) + + + + + + + pubmed:24762290 + + a(MESH:Pons) association complex(CONSO:"alpha-4 beta-2 nAChR") + + + + + + + pubmed:24762290 + + a(MESH:Mesencephalon) association complex(CONSO:"alpha-4 beta-2 nAChR") + + + + + + + pubmed:24762290 + + a(MESH:"Parietal Lobe") association complex(CONSO:"alpha-4 beta-2 nAChR") + + + + + + + pubmed:30697142 + + complex(a(CHEBI:acetylcholine), p(HGNC:CHRNA7)) increases bp(MESH:Neuroprotection) + + + + + + + pubmed:30697142 + + a(CHEBI:nornicotine) increases path(MESH:"Tobacco Use Disorder") + + + + + + + pubmed:30697142 + + a(CHEBI:nornicotine) increases act(p(HGNC:CHRNA7)) + + + + + + + pubmed:30697142 + + a(CHEBI:nornicotine) increases bp(MESH:Neuroprotection) + + + + + + + + + pubmed:30697142 + + a(CHEBI:nornicotine) decreases path(MESH:"Plaque, Amyloid") + + + + + + + pubmed:30697142 + + a(CHEBI:nornicotine) decreases a(CONSO:"amyloid-beta aggregates") + + + + + + + pubmed:30697142 + + a(CHEBI:nornicotine) decreases path(CONSO:neurotoxicity) + + + + + + + + + pubmed:30697142 + + path(MESH:"Tobacco Smoking") increases bp(MESH:Metabolism) + + + + + + + pubmed:30697142 + + complex(a(CHEBI:nicotine), p(HGNC:CYP2A6)) increases a(CHEBI:"(-)-cotinine") + + + + + + + pubmed:30697142 + + complex(a(CHEBI:"(-)-cotinine"), p(NCIT:C18024)) increases a(CHEBI:trans-3-hydroxycotinine) + + + + + + + pubmed:30697142 + + complex(a(CHEBI:"(-)-cotinine"), p(NCIT:C18024)) increases a(CHEBI:"trans-3-hydroxycotinine beta-D-glucuronide") + + + + + + + pubmed:30697142 + + complex(a(CHEBI:"(-)-cotinine"), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases bp(GO:"response to nicotine") + + + + + + + pubmed:30697142 + + complex(a(CHEBI:"(-)-cotinine"), p(HGNC:CHRNA7)) increases act(a(CHEBI:"(-)-cotinine")) + + + + + + + pubmed:30697142 + + complex(a(CHEBI:"(-)-cotinine"), p(HGNC:CHRNA7)) increases act(p(FPLX:AKT)) + + + + + + + pubmed:30697142 + + complex(a(CHEBI:"(-)-cotinine"), p(HGNC:CHRNA7)) increases act(p(FPLX:AKT)) + + + + + + + pubmed:30697142 + + complex(a(CHEBI:"(-)-cotinine"), p(HGNC:CHRNA7)) increases p(HGNC:PIK3CA) + + + + + + + pubmed:30697142 + + complex(a(CHEBI:"(-)-cotinine"), p(HGNC:CHRNA7)) decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:30697142 + + complex(a(CHEBI:"(-)-cotinine"), p(HGNC:CHRNA7)) decreases act(p(HGNC:GSK3B)) + + + + + + + pubmed:30697142 + + composite(a(CHEBI:"(-)-cotinine"), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) decreases p(HGNC:TNF) + + + + + + + pubmed:30697142 + + composite(a(CHEBI:"(-)-cotinine"), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) decreases p(HGNC:IL1B) + + + + + + + pubmed:30697142 + + composite(a(CHEBI:"(-)-cotinine"), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) decreases p(HGNC:IL6) + + + + + + + pubmed:30697142 + + composite(a(CHEBI:"(-)-cotinine"), p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) increases p(HGNC:IL10) + + + + + + + pubmed:30697142 + + composite(a(CHEBI:"(-)-cotinine"), p(HGNCGENEFAMILY:"NF-kappa B complex subunits")) increases p(HGNC:IL10) + + + + + + + pubmed:30697142 + + composite(a(CHEBI:"(-)-cotinine"), p(HGNCGENEFAMILY:"NF-kappa B complex subunits")) decreases p(HGNC:TNF) + + + + + + + pubmed:30697142 + + composite(a(CHEBI:"(-)-cotinine"), p(HGNCGENEFAMILY:"NF-kappa B complex subunits")) decreases p(HGNC:IL1B) + + + + + + + pubmed:30697142 + + composite(a(CHEBI:"(-)-cotinine"), p(HGNCGENEFAMILY:"NF-kappa B complex subunits")) decreases p(HGNC:IL6) + + + + + + + pubmed:30697142 + + complex(a(CHEBI:"(-)-cotinine"), a(CHEBI:"iron cation")) decreases a(CHEBI:"reactive oxygen species") + + + + + + + + + + + pubmed:30697142 + + complex(a(CHEBI:"iron cation"), a(CHEBI:nicotine)) decreases a(CHEBI:"reactive oxygen species") + + + + + + + pubmed:11230871 + + bp(MESH:"Lipid Peroxidation") decreases p(FPLX:CHRN) + + + + + + + pubmed:30697142 + + complex(a(CHEBI:nornicotine), p(HGNC:CHRNA7)) increases bp(GO:cognition) + + + + + + + pubmed:30697142 + + complex(a(CHEBI:nornicotine), p(HGNC:CHRNA7)) increases path(MESH:Attention) + + + + + + + pubmed:21718217 + + a(CONSO:CONSO00089) association bp(GO:"microglial cell activation") + + + + + + + pubmed:21718217 + + a(CONSO:CONSO00089) positiveCorrelation bp(GO:"microglial cell activation") + + + + + + + pubmed:21718217 + + a(CONSO:CONSO00089) increases tloc(p(HGNC:IFNG), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:21718217 + + a(CONSO:CONSO00089) increases tloc(p(HGNC:TNF), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:21718217 + + a(CONSO:CONSO00089) increases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:21718217 + + a(CONSO:CONSO00089) increases tloc(p(HGNC:IL6), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:21718217 + + a(CONSO:CONSO00089) increases tloc(p(HGNC:CCL2), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:21718217 + + act(p(HGNC:PPARG)) increases path(MESH:"Alzheimer Disease") + + + + + + + pubmed:21718217 + + act(p(HGNC:PPARG)) increases deg(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:21718217 + + act(p(HGNC:PPARG)) increases bp(GO:"reverse cholesterol transport") + + + + + + + pubmed:21718217 + + act(p(HGNC:PPARG)) decreases bp(GO:"microglial cell activation involved in immune response") + + + + + + + pubmed:21718217 + + p(HGNC:PPARG) association bp(MESH:"Energy Metabolism") + + + + + + + pubmed:21718217 + + p(HGNC:PPARG) increases bp(GO:"fat cell differentiation") + + + + + + + pubmed:21718217 + + p(HGNC:PPARG) association bp(GO:"response to insulin") + + + + + + + pubmed:21718217 + + p(HGNC:PPARG) association bp(GO:"lipid storage") + + + + + + + pubmed:21718217 + + p(HGNC:PPARG) increases p(HGNC:APOE) + + + + + + + pubmed:21718217 + + p(HGNC:PPARG) increases p(HGNC:ABCA1) + + + + + + + pubmed:21718217 + + p(HGNC:PPARG) increases p(HGNC:NR1H3) + + + + + + + pubmed:21718217 + + act(p(HGNC:PPARG)) increases p(HGNC:ARG1) + + + + + + + pubmed:21718217 + + act(p(HGNC:PPARG)) increases p(HGNC:IL4) + + + + + + + + + pubmed:20556492 + + p(HGNC:PPARG) regulates bp(GO:"lipid biosynthetic process") + + + + + + + pubmed:20556492 + + p(HGNC:PPARG) regulates bp(GO:"lipid metabolic process") + + + + + + + + + pubmed:21718217 + + act(p(HGNC:NR1H3)) increases path(MESH:"Alzheimer Disease") + + + + + + + pubmed:21718217 + + act(p(HGNC:NR1H3)) increases deg(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:21718217 + + act(p(HGNC:NR1H3)) increases deg(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:21718217 + + act(p(HGNC:NR1H3)) increases bp(GO:"reverse cholesterol transport") + + + + + + + pubmed:21718217 + + act(p(HGNC:NR1H3)) decreases bp(GO:"microglial cell activation involved in immune response") + + + + + + + + + pubmed:21718217 + + p(HGNC:NR1H3) association bp(GO:"cholesterol homeostasis") + + + + + + + pubmed:21718217 + + p(HGNC:NR1H3) association bp(GO:"negative regulation of inflammatory response") + + + + + + + pubmed:21718217 + + p(HGNC:NR1H3) increases p(HGNC:APOE) + + + + + + + pubmed:21718217 + + act(p(HGNC:NR1H3)) increases act(p(HGNC:APOE)) + + + + + + + pubmed:21718217 + + p(HGNC:NR1H3) increases p(HGNC:ABCA1) + + + + + + + pubmed:21718217 + + act(p(HGNC:NR1H3)) increases bp(GO:memory) + + + + + + + pubmed:21718217 + + act(p(HGNC:NR1H3)) decreases bp(GO:"microglial cell activation") + + + + + + + + + pubmed:21718217 + + p(FPLX:PPAR) association bp(MESH:"Energy Metabolism") + + + + + + + pubmed:21718217 + + p(FPLX:PPAR) positiveCorrelation bp(MESH:"Energy Metabolism") + + + + + + + pubmed:21718217 + + p(FPLX:PPAR) association bp(GO:"fat cell differentiation") + + + + + + + pubmed:21718217 + + p(FPLX:PPAR) positiveCorrelation bp(GO:"fat cell differentiation") + + + + + + + pubmed:21718217 + + p(FPLX:PPAR) association bp(GO:"response to insulin") + + + + + + + pubmed:21718217 + + p(FPLX:PPAR) positiveCorrelation bp(GO:"response to insulin") + + + + + + + pubmed:21718217 + + p(FPLX:PPAR) association bp(GO:"response to tumor cell") + + + + + + + pubmed:21718217 + + p(FPLX:PPAR) positiveCorrelation bp(GO:"response to tumor cell") + + + + + + + pubmed:21718217 + + p(FPLX:PPAR) regulates bp(GO:"lipid metabolic process") + + + + + + + pubmed:21718217 + + act(p(FPLX:PPAR)) decreases bp(GO:"microglial cell activation") + + + + + + + + + + + pubmed:21718217 + + act(p(FPLX:RXR)) increases p(HGNC:APOE) + + + + + + + pubmed:21718217 + + act(p(FPLX:RXR)) increases p(HGNC:ABCA1) + + + + + + + pubmed:21718217 + + bp(GO:"fat cell differentiation") association p(FPLX:PPAR) + + + + + + + pubmed:21718217 + + bp(GO:"fat cell differentiation") positiveCorrelation p(FPLX:PPAR) + + + + + + + pubmed:21718217 + + bp(GO:"response to insulin") association p(FPLX:PPAR) + + + + + + + pubmed:21718217 + + bp(GO:"response to insulin") positiveCorrelation p(FPLX:PPAR) + + + + + + + pubmed:21718217 + + bp(GO:"response to insulin") association p(HGNC:PPARG) + + + + + + + pubmed:21718217 + + bp(GO:"response to tumor cell") association p(FPLX:PPAR) + + + + + + + pubmed:21718217 + + bp(GO:"response to tumor cell") positiveCorrelation p(FPLX:PPAR) + + + + + + + pubmed:30688256 + + bp(GO:"lipid oxidation") association bp(GO:mitophagy) + + + + + + + pubmed:27299292 + + bp(GO:"lipid oxidation") positiveCorrelation p(HGNC:TFEB) + + + + + + + pubmed:21718217 + + bp(GO:"lipid storage") association p(HGNC:PPARG) + + + + + + + pubmed:21718217 + + p(HGNC:PPARD) association bp(GO:"fatty acid oxidation") + + + + + + + pubmed:21718217 + + act(p(HGNC:PPARD)) increases bp(GO:"reverse cholesterol transport") + + + + + + + pubmed:21718217 + + act(p(HGNC:PPARD)) increases bp(GO:"negative regulation of inflammatory response") + + + + + + + pubmed:21718217 + + act(p(HGNC:PPARD)) increases p(HGNC:ARG1) + + + + + + + pubmed:21718217 + + act(p(HGNC:PPARD)) increases p(HGNC:IL4) + + + + + + + pubmed:21718217 + + bp(GO:"fatty acid oxidation") association p(HGNC:PPARD) + + + + + + + pubmed:21718217 + + a(CHEBI:oxysterol) increases act(p(HGNC:NR1H3)) + + + + + + + pubmed:21718217 + + a(CHEBI:oxysterol) increases act(p(HGNC:NR1H3)) + + + + + + + pubmed:21718217 + + bp(GO:"negative regulation of inflammatory response") association p(HGNC:NR1H3) + + + + + + + pubmed:21718217 + + p(HGNC:ABCA1) increases p(HGNC:APOE) + + + + + + + pubmed:21718217 + + p(HGNC:ABCA1) decreases a(CONSO:CONSO00018) + + + + + + + pubmed:21718217 + + a(CHEBI:"GW 3965") directlyIncreases act(p(HGNC:NR1H3)) + + + + + + + pubmed:21718217 + + a(CHEBI:"GW 3965") increases act(p(HGNC:NR1H3)) + + + + + + + pubmed:21718217 + + a(CHEBI:"GW 3965") increases p(HGNC:APOE) + + + + + + + pubmed:21718217 + + a(CHEBI:"GW 3965") increases p(HGNC:ABCA1) + + + + + + + pubmed:21718217 + + a(CHEBI:"GW 3965") decreases a(CONSO:CONSO00018) + + + + + + + pubmed:21718217 + + a(CHEBI:"GW 3965") increases bp(GO:memory) + + + + + + + pubmed:21718217 + + a(CHEBI:"GW 3965") decreases path(MESH:Inflammation) + + + + + + + pubmed:21718217 + + a(CHEBI:"GW 3965") increases act(a(CONSO:CONSO00038)) + + + + + + + pubmed:21718217 + + a(CHEBI:"GW 3965") increases bp(GO:phagocytosis) + + + + + + + pubmed:21718217 + + p(MGI:Abca1) decreases a(CHEBI:amyloid-beta) + + + + + + + pubmed:21718217 + + p(MGI:Abca1) decreases a(CONSO:CONSO00038) + + + + + + + pubmed:21718217 + + a(CHEBI:pioglitazone) increases act(p(HGNC:PPARG)) + + + + + + + pubmed:21718217 + + a(CHEBI:pioglitazone) decreases path(MESH:"Diabetes Mellitus, Type 2") + + + + + + + pubmed:21718217 + + a(CHEBI:pioglitazone) decreases a(CONSO:CONSO00018) + + + + + + + pubmed:21718217 + + a(CHEBI:pioglitazone) decreases a(CONSO:CONSO00018) + + + + + + + pubmed:21718217 + + a(CHEBI:pioglitazone) decreases a(CHEBI:"amyloid-beta polypeptide 42") + + + + + + + pubmed:21718217 + + a(CHEBI:pioglitazone) increases bp(GO:behavior) + + + + + + + pubmed:21718217 + + a(CHEBI:pioglitazone) increases p(MGI:Abca1) + + + + + + + pubmed:21718217 + + a(CHEBI:pioglitazone) increases p(MGI:Apoe) + + + + + + + pubmed:21718217 + + a(CHEBI:pioglitazone) increases bp(GO:memory) + + + + + + + pubmed:21718217 + + a(CHEBI:pioglitazone) increases bp(GO:cognition) + + + + + + + pubmed:29626319 + + a(CHEBI:pioglitazone) decreases a(CHEBI:amyloid-beta) + + + + + + + pubmed:21718217 + + a(CHEBI:rosiglitazone) increases act(p(HGNC:PPARG)) + + + + + + + pubmed:21718217 + + a(CHEBI:rosiglitazone) increases act(p(HGNC:PPARG)) + + + + + + + pubmed:20556492 + + a(CHEBI:rosiglitazone) increases p(HGNC:PPARG) + + + + + + + pubmed:29626319 + + a(CHEBI:rosiglitazone) increases act(p(HGNC:PPARG)) + + + + + + + pubmed:21718217 + + a(CHEBI:rosiglitazone) decreases path(MESH:"Diabetes Mellitus, Type 2") + + + + + + + pubmed:21718217 + + a(CHEBI:rosiglitazone) increases bp(GO:behavior) + + + + + + + pubmed:21718217 + + a(CHEBI:rosiglitazone) causesNoChange a(CONSO:CONSO00018) + + + + + + + pubmed:21718217 + + a(CHEBI:rosiglitazone) decreases a(CONSO:CONSO00018) + + + + + + + pubmed:21718217 + + a(CHEBI:rosiglitazone) decreases a(CHEBI:"amyloid-beta polypeptide 42") + + + + + + + pubmed:21718217 + + a(CHEBI:rosiglitazone) decreases a(CHEBI:amyloid-beta) + + + + + + + pubmed:29626319 + + a(CHEBI:rosiglitazone) increases deg(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:21718217 + + a(CHEBI:rosiglitazone) increases bp(GO:"learning or memory") + + + + + + + pubmed:21718217 + + a(CHEBI:rosiglitazone) increases p(MGI:Ctnnb1) + + + + + + + pubmed:21718217 + + a(CHEBI:rosiglitazone) decreases p(MGI:Gsk3b) + + + + + + + pubmed:21718217 + + a(CHEBI:rosiglitazone) increases p(MGI:Abca1) + + + + + + + pubmed:21718217 + + a(CHEBI:rosiglitazone) increases bp(GO:memory) + + + + + + + pubmed:21718217 + + a(CHEBI:rosiglitazone) increases bp(GO:cognition) + + + + + + + pubmed:20556492 + + a(CHEBI:rosiglitazone) decreases act(a(CHEBI:thapsigargin)) + + + + + + + pubmed:20556492 + + a(CHEBI:rosiglitazone) increases bp(GO:"regulation of membrane potential") + + + + + + + pubmed:20556492 + + a(CHEBI:rosiglitazone) decreases path(HP:"Increased reactive oxygen species production") + + + + + + + pubmed:29626319 + + a(CHEBI:rosiglitazone) increases p(HGNC:CD36) + + + + + + + pubmed:29626319 + + a(CHEBI:rosiglitazone) increases act(a(MESH:Microglia)) + + + + + + + pubmed:22798221 + + act(p(MGI:Gsk3b), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + + + + + + + pubmed:22798221 + + act(p(MGI:Gsk3b), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 198)) + + + + + + + pubmed:22798221 + + act(p(MGI:Gsk3b), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) + + + + + + + pubmed:22798221 + + act(p(MGI:Gsk3b), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) + + + + + + + pubmed:22798221 + + act(p(MGI:Gsk3b), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) + + + + + + + pubmed:22798221 + + act(p(MGI:Gsk3b), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) + + + + + + + pubmed:22798221 + + act(p(MGI:Gsk3b), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) + + + + + + + pubmed:22798221 + + act(p(MGI:Gsk3b), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) + + + + + + + + + pubmed:29121589 + + act(p(MGI:Gsk3b), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Dpysl2, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:29121589 + + act(p(MGI:Gsk3b), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + + + + + pubmed:21718217 + + a(CHEBI:"GW 501516") increases act(p(HGNC:PPARD)) + + + + + + + pubmed:21718217 + + a(CHEBI:"GW 501516") increases p(HGNC:ABCA1) + + + + + + + pubmed:21718217 + + a(CHEBI:"GW 501516") increases p(HGNC:APOA1) + + + + + + + pubmed:21718217 + + a(CHEBI:"GW 501516") decreases a(CONSO:CONSO00018) + + + + + + + pubmed:21718217 + + a(CHEBI:"GW 501516") increases p(HGNC:MME) + + + + + + + pubmed:21718217 + + a(CHEBI:"GW 501516") increases p(HGNC:IDE) + + + + + + + pubmed:21718217 + + a(CHEBI:"all-trans-retinoic acid") increases act(p(FPLX:RXR)) + + + + + + + pubmed:21718217 + + a(CHEBI:"all-trans-retinoic acid") increases act(p(FPLX:RAR)) + + + + + + + pubmed:21718217 + + a(CHEBI:"all-trans-retinoic acid") decreases a(CONSO:CONSO00018) + + + + + + + pubmed:21718217 + + a(CHEBI:"all-trans-retinoic acid") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:21718217 + + a(CHEBI:"all-trans-retinoic acid") increases bp(GO:memory) + + + + + + + pubmed:26400044 + + a(CHEBI:"all-trans-retinoic acid") decreases path(MESH:"Plaque, Amyloid") + + + + + + + pubmed:26400044 + + a(CHEBI:"all-trans-retinoic acid") decreases bp(CONSO:"APP processing") + + + + + + + pubmed:26400044 + + a(CHEBI:"all-trans-retinoic acid") decreases a(CHEBI:amyloid-beta) + + + + + + + pubmed:26400044 + + a(CHEBI:"all-trans-retinoic acid") decreases act(p(MGI:Cdk5), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:26400044 + + a(CHEBI:"all-trans-retinoic acid") decreases act(p(MGI:Gsk3b), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:26400044 + + a(CHEBI:"all-trans-retinoic acid") decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:26400044 + + a(CHEBI:"all-trans-retinoic acid") decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:27181519 + + a(CHEBI:"all-trans-retinoic acid") association bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") + + + + + + + pubmed:27181519 + + a(CHEBI:"all-trans-retinoic acid") association bp(GO:autophagy) + + + + + + + pubmed:27181519 + + a(CHEBI:"all-trans-retinoic acid") negativeCorrelation path(DOID:"amyotrophic lateral sclerosis") + + + + + + + pubmed:21718217 + + a(CHEBI:bexarotene) increases act(p(FPLX:RXR)) + + + + + + + pubmed:21718217 + + a(CHEBI:bexarotene) increases p(HGNC:APOE) + + + + + + + pubmed:21718217 + + a(CHEBI:bexarotene) increases p(HGNC:ABCA1) + + + + + + + pubmed:21718217 + + a(CHEBI:bexarotene) decreases a(CONSO:CONSO00018) + + + + + + + pubmed:21718217 + + a(CHEBI:bexarotene) increases bp(GO:behavior) + + + + + + + pubmed:27181519 + + a(CHEBI:bexarotene) isA a(CHEBI:"retinoid X receptor agonist") + + + + + + + pubmed:27181519 + + a(CHEBI:bexarotene) decreases path(MESH:"Motor Neuron Disease") + + + + + + + pubmed:27181519 + + a(CHEBI:bexarotene) decreases path(DOID:"amyotrophic lateral sclerosis") + + + + + + + pubmed:21718217 + + a(CHEBI:Honokiol) increases act(p(FPLX:RXR)) + + + + + + + pubmed:21718217 + + a(CHEBI:Honokiol) increases act(complex(p(FPLX:RXR), p(HGNC:NR1H3))) + + + + + + + pubmed:21718217 + + a(CHEBI:Honokiol) increases p(HGNC:APOE) + + + + + + + pubmed:21718217 + + a(CHEBI:Honokiol) increases p(HGNC:ABCA1) + + + + + + + pubmed:21718217 + + r(HGNC:ARG1) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:28445721 + + path(MESH:Motivation) association p(FPLX:CHRN) + + + + + + + pubmed:30985105 + + bp(GO:"dopamine secretion") association p(HGNC:SNCA) + + + + + + + pubmed:30985105 + + bp(GO:"dopamine secretion") association bp(GO:"musculoskeletal movement") + + + + + + + pubmed:28445721 + + bp(MESH:"Physiological Phenomena") association a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") + + + + + + + pubmed:28445721 + + p(HGNC:TMEM35A) regulates act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + + + + + + + pubmed:28445721 + + act(p(HGNC:TMEM35A), ma(go:0044183 ! "protein binding involved in protein folding")) regulates tloc(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) + + + + + + + pubmed:28445721 + + act(p(HGNC:TMEM35A), ma(go:0044183 ! "protein binding involved in protein folding")) regulates a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") + + + + + + + pubmed:28445721 + + act(p(HGNC:TMEM35A), ma(go:0044183 ! "protein binding involved in protein folding")) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + + + + + + + pubmed:28445721 + + act(p(HGNC:TMEM35A), ma(go:0044183 ! "protein binding involved in protein folding")) increases tloc(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) + + + + + + + pubmed:28445721 + + act(p(HGNC:TMEM35A), ma(go:0044183 ! "protein binding involved in protein folding")) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") + + + + + + + pubmed:28445721 + + act(p(HGNC:TMEM35A), ma(go:0044183 ! "protein binding involved in protein folding")) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") + + + + + + + pubmed:28445721 + + act(p(HGNC:TMEM35A), ma(go:0044183 ! "protein binding involved in protein folding")) increases tloc(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) + + + + + + + pubmed:28445721 + + p(HGNC:TMEM35A) causesNoChange act(p(FPLX:GABR)) + + + + + + + pubmed:28445721 + + p(HGNC:TMEM35A) causesNoChange act(a(MESH:"Receptors, Serotonin")) + + + + + + + pubmed:28445721 + + p(HGNC:TMEM35A) causesNoChange act(p(HGNC:TRPV1)) + + + + + + + pubmed:28445721 + + p(HGNC:TMEM35A) causesNoChange act(a(MESH:"Receptors, Glutamate")) + + + + + + + pubmed:28445721 + + act(p(HGNC:TMEM35A), ma(go:0044183 ! "protein binding involved in protein folding")) increases act(p(CONSO:CONSO00174)) + + + + + + + pubmed:28445721 + + act(p(HGNC:TMEM35A), ma(go:0044183 ! "protein binding involved in protein folding")) increases tloc(p(CONSO:CONSO00174), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) + + + + + + + pubmed:28445721 + + act(p(HGNC:TMEM35A), ma(go:0044183 ! "protein binding involved in protein folding")) increases p(CONSO:CONSO00174) + + + + + + + pubmed:28445721 + + act(p(HGNC:TMEM35A), ma(go:0044183 ! "protein binding involved in protein folding")) increases act(a(MESH:"nicotinic receptor alpha3beta2")) + + + + + + + pubmed:28445721 + + act(p(HGNC:TMEM35A), ma(go:0044183 ! "protein binding involved in protein folding")) increases tloc(a(MESH:"nicotinic receptor alpha3beta2"), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) + + + + + + + pubmed:28445721 + + act(p(HGNC:TMEM35A), ma(go:0044183 ! "protein binding involved in protein folding")) increases a(MESH:"nicotinic receptor alpha3beta2") + + + + + + + pubmed:28445721 + + act(p(HGNC:TMEM35A), ma(go:0044183 ! "protein binding involved in protein folding")) increases act(a(MESH:"nicotinic receptor alpha3beta4")) + + + + + + + pubmed:28445721 + + act(p(HGNC:TMEM35A), ma(go:0044183 ! "protein binding involved in protein folding")) increases tloc(a(MESH:"nicotinic receptor alpha3beta4"), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) + + + + + + + pubmed:28445721 + + act(p(HGNC:TMEM35A), ma(go:0044183 ! "protein binding involved in protein folding")) increases a(MESH:"nicotinic receptor alpha3beta4") + + + + + + + pubmed:28445721 + + act(p(HGNC:TMEM35A), ma(go:0044183 ! "protein binding involved in protein folding")) increases complex(a(CHEBI:epibatidine), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + + + + + + + pubmed:28445721 + + act(p(HGNC:TMEM35A), ma(go:0044183 ! "protein binding involved in protein folding")) increases complex(a(CHEBI:epibatidine), a(MESH:"nicotinic receptor alpha3beta2")) + + + + + + + pubmed:28445721 + + act(p(HGNC:TMEM35A), ma(go:0044183 ! "protein binding involved in protein folding")) increases complex(a(CHEBI:epibatidine), p(CONSO:CONSO00174)) + + + + + + + pubmed:28445721 + + act(p(HGNC:TMEM35A), ma(go:0044183 ! "protein binding involved in protein folding")) increases complex(a(CHEBI:epibatidine), a(MESH:"nicotinic receptor alpha3beta4")) + + + + + + + + + + + + + pubmed:28445721 + + p(HGNC:TMEM35A) increases complex(a(CHEBI:epibatidine), a(MESH:"alpha6beta2 nicotinic acetylcholine receptor")) + + + + + + + pubmed:28445721 + + p(HGNC:TMEM35A) increases complex(a(CHEBI:epibatidine), a(MESH:"alpha6beta2 nicotinic acetylcholine receptor")) + + + + + + + pubmed:28445721 + + p(HGNC:TMEM35A) increases a(MESH:"alpha6beta2 nicotinic acetylcholine receptor") + + + + + + + pubmed:28445721 + + act(p(MGI:Tmem35a), ma(go:0044183 ! "protein binding involved in protein folding")) increases a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") + + + + + + + pubmed:28445721 + + p(MGI:Tmem35a) association p(MGI:Canx) + + + + + + + pubmed:28445721 + + p(MGI:Tmem35a) increases complex(a(MESH:Bungarotoxins), p(FPLX:CHRN)) + + + + + + + pubmed:28445721 + + p(MGI:Tmem35a) increases complex(a(CHEBI:epibatidine), p(CONSO:CONSO00180)) + + + + + + + pubmed:28445721 + + p(MGI:Tmem35a) increases complex(a(CHEBI:epibatidine), p(CONSO:CONSO00174)) + + + + + + + pubmed:28445721 + + p(MGI:Tmem35a) increases p(CONSO:CONSO00180) + + + + + + + pubmed:28445721 + + p(MGI:Tmem35a) increases complex(a(MESH:Bungarotoxins), loc(GO:membrane)) + + + + + + + pubmed:28445721 + + p(MGI:Tmem35a) increases p(FPLX:CHRN) + + + + + + + pubmed:28445721 + + p(MGI:Tmem35a) regulates p(FPLX:CHRN) + + + + + + + pubmed:28445721 + + p(MGI:Tmem35a) increases a(MESH:"nicotinic receptor alpha3beta4") + + + + + + + pubmed:28445721 + + p(MGI:Tmem35a) decreases bp(GO:locomotion) + + + + + + + pubmed:28445721 + + p(MGI:Tmem35a) decreases bp(GO:locomotion) + + + + + + + pubmed:28445721 + + p(MGI:Tmem35a) association bp(GO:"temperature homeostasis") + + + + + + + pubmed:28445721 + + p(MGI:Tmem35a) increases bp(GO:learning) + + + + + + + pubmed:28445721 + + p(MGI:Tmem35a) increases bp(GO:memory) + + + + + + + pubmed:28445721 + + p(MGI:Tmem35a) increases path(MESH:"Spatial Learning") + + + + + + + pubmed:28445721 + + p(MGI:Tmem35a) increases path(MESH:"Spatial Memory") + + + + + + + + + + + + + pubmed:11230871 + + complex(a(CHEBI:epibatidine), p(FPLX:CHRN)) negativeCorrelation bp(GO:aging) + + + + + + + pubmed:11230871 + + complex(a(CHEBI:epibatidine), p(FPLX:CHRN)) negativeCorrelation bp(GO:aging) + + + + + + + pubmed:28445721 + + composite(p(HGNC:RIC3), p(HGNC:TMEM35A)) increases complex(a(CHEBI:epibatidine), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + + + + + + + pubmed:28445721 + + composite(p(HGNC:RIC3), p(HGNC:TMEM35A)) increases complex(a(CHEBI:epibatidine), a(MESH:"nicotinic receptor alpha3beta2")) + + + + + + + pubmed:28445721 + + composite(a(MESH:Bungarotoxins), p(HGNC:TMEM35A)) decreases complex(a(CHEBI:epibatidine), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + + + + + + + pubmed:28445721 + + p(MGI:Canx) association p(MGI:Tmem35a) + + + + + + + pubmed:28445721 + + composite(a(CHEBI:nicotine), p(HGNC:TMEM35A)) increases p(CONSO:CONSO00174) + + + + + + + pubmed:18174175 + + complex(a(CHEBI:epibatidine), a(MESH:"alpha6beta2 nicotinic acetylcholine receptor")) increases act(a(MESH:"alpha6beta2 nicotinic acetylcholine receptor")) + + + + + + + + + pubmed:21787755 + + a(MESH:"alpha6beta2 nicotinic acetylcholine receptor") regulates tloc(a(CHEBI:"gamma-aminobutyric acid"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:28445721 + + a(MESH:"alpha-conotoxin MII") decreases complex(a(CHEBI:epibatidine), a(MESH:"alpha6beta2 nicotinic acetylcholine receptor")) + + + + + + + pubmed:21787755 + + a(MESH:"alpha-conotoxin MII") decreases act(p(CONSO:"alpha-3 beta-2 nAChR")) + + + + + + + + + pubmed:28445721 + + bp(GO:"temperature homeostasis") association p(MGI:Tmem35a) + + + + + + + pubmed:21482353 + + p(HGNC:CHRNA4, var("?")) positiveCorrelation path(MESH:Epilepsy) + + + + + + + pubmed:21482353 + + p(HGNC:CHRNA4, var("?")) increases path(CONSO:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") + + + + + + + pubmed:21482353 + + p(HGNC:CHRNB2, var("?")) positiveCorrelation path(MESH:Epilepsy) + + + + + + + pubmed:21482353 + + p(HGNC:CHRNB2, var("?")) increases path(CONSO:"Autosomal Dominant Nocturnal Frontal Lobe Epilepsy") + + + + + + + pubmed:21482353 + + p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:"Tobacco Use Disorder") + + + + + + + pubmed:21482353 + + p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:"Tobacco Use Disorder") + + + + + + + pubmed:21482353 + + p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:Alcoholism) + + + + + + + pubmed:21482353 + + p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:"Cocaine-Related Disorders") + + + + + + + pubmed:21482353 + + p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:"Opioid-Related Disorders") + + + + + + + pubmed:21482353 + + p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:"Lung Neoplasms") + + + + + + + pubmed:21482353 + + p(HGNC:CHRNA5, var("?")) positiveCorrelation bp(GO:cognition) + + + + + + + pubmed:21482353 + + complex(p(FPLX:CHRN), p(HGNC:RIC3)) increases p(FPLX:CHRN) + + + + + + + pubmed:21482353 + + complex(p(FPLX:CHRN), p(HGNC:RIC3)) increases act(p(FPLX:CHRN)) + + + + + + + pubmed:21482353 + + complex(a(INTERPRO:"14-3-3 protein"), p(FPLX:CHRN)) increases p(FPLX:CHRN) + + + + + + + pubmed:21482353 + + complex(a(INTERPRO:"14-3-3 protein"), p(FPLX:CHRN)) increases act(p(FPLX:CHRN)) + + + + + + + + + pubmed:21482353 + + complex(p(FPLX:CHRN), p(INTERPRO:Neurexin)) increases p(FPLX:CHRN) + + + + + + + pubmed:21482353 + + complex(p(FPLX:CHRN), p(INTERPRO:Neurexin)) increases act(p(FPLX:CHRN)) + + + + + + + + + pubmed:21482353 + + complex(p(FPLX:CHRN), p(HGNC:VSNL1)) increases p(FPLX:CHRN) + + + + + + + pubmed:21482353 + + complex(p(FPLX:CHRN), p(HGNC:VSNL1)) increases act(p(FPLX:CHRN)) + + + + + + + + + pubmed:19721446 + + p(HGNC:VSNL1) association p(HGNC:CHRNA4, frag("331_600")) + + + + + + + pubmed:21482353 + + complex(p(FPLX:CHRN), p(HGNC:LYNX1)) regulates act(p(FPLX:CHRN)) + + + + + + + pubmed:21482353 + + complex(p(FPLX:CHRN), p(HGNC:LYNX1)) association act(p(FPLX:CHRN)) + + + + + + + pubmed:21482353 + + complex(p(FPLX:CHRN), p(HGNC:LYNX1)) association tloc(p(FPLX:CHRN), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) + + + + + + + pubmed:21482353 + + composite(p(CONSO:"alpha-4 beta-2 nAChR"), p(HGNC:LYNX1)) decreases act(p(FPLX:CHRN)) + + + + + + + pubmed:21482353 + + complex(p(CONSO:"alpha-4 beta-2 nAChR"), p(HGNC:LYNX1)) regulates act(p(CONSO:"alpha-4 beta-2 nAChR")) + + + + + + + pubmed:21482353 + + complex(p(HGNC:CHRNA3), p(HGNC:LYNX1)) regulates act(p(HGNC:CHRNA3)) + + + + + + + pubmed:21482353 + + complex(p(CONSO:"alpha-7-containing nAChR"), p(HGNC:LYNX1)) regulates act(p(CONSO:"alpha-7-containing nAChR")) + + + + + + + pubmed:21482353 + + p(MGI:Lynx1) decreases a(CHEBI:"calcium(2+)") + + + + + + + pubmed:21482353 + + p(MGI:Lynx1) decreases bp(MESH:"Synaptic Transmission") + + + + + + + pubmed:21482353 + + p(MGI:Lynx1) decreases bp(GO:learning) + + + + + + + pubmed:21482353 + + p(MGI:Lynx1) decreases bp(GO:memory) + + + + + + + pubmed:21482353 + + p(MGI:Lynx1) decreases bp(MESH:"Dominance, Ocular") + + + + + + + pubmed:21482353 + + p(MGI:Lynx1) decreases bp(GO:"synaptic transmission, cholinergic") + + + + + + + pubmed:21482353 + + p(MGI:Lynx1) increases a(MESH:Neurons) + + + + + + + pubmed:21482353 + + p(MGI:Slc12a2) increases act(p(MGI:Lynx1)) + + + + + + + pubmed:21482353 + + p(FPLX:ADCY, var("?")) decreases act(p(MGI:Lynx1)) + + + + + + + pubmed:21482353 + + p(HGNC:PSCA) decreases bp(GO:"programmed cell death") + + + + + + + pubmed:21482353 + + bp(GO:"synapse maturation") negativeCorrelation p(HGNC:LYNX1) + + + + + + + pubmed:21482353 + + bp(GO:"GABAergic neuron differentiation") association path(MESH:Schizophrenia) + + + + + + + pubmed:21482353 + + bp(GO:"GABAergic neuron differentiation") association path(MESH:Amblyopia) + + + + + + + pubmed:21482353 + + path(MESH:Amblyopia) association bp(GO:"GABAergic neuron differentiation") + + + + + + + pubmed:21482353 + + a(HP:"inhibitory interneuron") regulates bp(GO:"sensory processing") + + + + + + + pubmed:21482353 + + act(a(HP:"inhibitory interneuron")) increases act(p(FPLX:NOS)) + + + + + + + pubmed:21482353 + + a(HP:"inhibitory interneuron") association a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") + + + + + + + pubmed:21482353 + + act(a(HP:"inhibitory interneuron")) negativeCorrelation g(HGNC:CHRFAM7A, var("?")) + + + + + + + pubmed:24563850 + + act(p(FPLX:NOS)) increases a(CHEBI:radical) + + + + + + + pubmed:24563850 + + act(p(FPLX:NOS)) increases a(CHEBI:"reactive oxygen species") + + + + + + + pubmed:21482353 + + a(MESH:"Brain Stem") regulates act(a(MESH:Hippocampus)) + + + + + + + pubmed:21482353 + + g(HGNC:CHRFAM7A, var("?")) association path(MESH:Schizophrenia) + + + + + + + pubmed:21482353 + + g(HGNC:CHRFAM7A, var("?")) negativeCorrelation act(a(HP:"inhibitory interneuron")) + + + + + + + pubmed:21482353 + + a(CONSO:GTS-21) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + + + + + + + pubmed:21482353 + + a(CONSO:GTS-21) increases path(MESH:Attention) + + + + + + + pubmed:21482353 + + a(CONSO:GTS-21) increases bp(GO:"sensory processing") + + + + + + + pubmed:21482353 + + a(CONSO:GTS-21) decreases path(MESH:Anhedonia) + + + + + + + pubmed:21482353 + + a(CONSO:GTS-21) decreases path(MESH:Aphasia) + + + + + + + pubmed:21482353 + + p(HGNC:SLC12A5) decreases a(CHEBI:chloride) + + + + + + + pubmed:21482353 + + p(HGNC:SLC12A5) regulates act(a(CHEBI:"gamma-aminobutyric acid")) + + + + + + + pubmed:21482353 + + p(HGNC:PEMT) increases a(CHEBI:phosphatidylcholine) + + + + + + + + + pubmed:21482353 + + a(CHEBI:phosphatidylcholine) increases a(CHEBI:choline) + + + + + + + pubmed:21482353 + + p(HGNC:PEMT, var("?")) association path(MESH:"Choline Deficiency") + + + + + + + pubmed:21482353 + + p(HGNC:PEMT, var("?")) association path(MESH:Schizophrenia) + + + + + + + pubmed:21482353 + + path(MESH:"Choline Deficiency") association p(HGNC:PEMT, var("?")) + + + + + + + pubmed:21482353 + + bp(GO:"response to cytokine") association p(CONSO:"alpha-7-containing nAChR") + + + + + + + pubmed:21482353 + + bp(MESH:"Stress, Physiological") increases a(CHEBI:dopamine) + + + + + + + pubmed:27299292 + + bp(MESH:"Stress, Physiological") increases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) + + + + + + + pubmed:23746257 + + bp(MESH:"Stress, Physiological") increases a(MESH:"Heat-Shock Proteins") + + + + + + + pubmed:25784053 + + bp(MESH:"Stress, Physiological") regulates bp(CONSO:Proteostasis) + + + + + + + pubmed:21482353 + + path(MESH:"Cocaine-Related Disorders") positiveCorrelation p(HGNC:CHRNA5, var("?")) + + + + + + + pubmed:21482353 + + path(MESH:"Cocaine-Related Disorders") positiveCorrelation p(HGNC:CHRNA3, var("?")) + + + + + + + pubmed:21482353 + + path(MESH:"Cocaine-Related Disorders") positiveCorrelation p(HGNC:CHRNB4, var("?")) + + + + + + + pubmed:21482353 + + path(MESH:"Opioid-Related Disorders") positiveCorrelation p(HGNC:CHRNA5, var("?")) + + + + + + + pubmed:21482353 + + path(MESH:"Opioid-Related Disorders") positiveCorrelation p(HGNC:CHRNA3, var("?")) + + + + + + + pubmed:21482353 + + path(MESH:"Opioid-Related Disorders") positiveCorrelation p(HGNC:CHRNB4, var("?")) + + + + + + + pubmed:21482353 + + path(MESH:"Lung Neoplasms") positiveCorrelation p(HGNC:CHRNA5, var("?")) + + + + + + + pubmed:21482353 + + path(MESH:"Lung Neoplasms") positiveCorrelation p(HGNC:CHRNA3, var("?")) + + + + + + + pubmed:21482353 + + path(MESH:"Lung Neoplasms") positiveCorrelation p(HGNC:CHRNB4, var("?")) + + + + + + + pubmed:19721446 + + path(MESH:"Lung Neoplasms") association g(HGNC:CHRNA5) + + + + + + + pubmed:19721446 + + path(MESH:"Lung Neoplasms") association g(HGNC:CHRNA3) + + + + + + + pubmed:19721446 + + path(MESH:"Lung Neoplasms") association g(HGNC:CHRNB4) + + + + + + + pubmed:28901280 + + path(MESH:"Lung Neoplasms") association g(DBSNP:rs1051730) + + + + + + + pubmed:28901280 + + path(MESH:"Lung Neoplasms") increases p(HGNC:CHRNA9) + + + + + + + pubmed:28901280 + + path(MESH:"Lung Neoplasms") increases p(HGNC:CHRNA5) + + + + + + + pubmed:28901280 + + path(MESH:"Lung Neoplasms") increases p(HGNC:CHRNA10) + + + + + + + pubmed:21482353 + + p(HGNC:CHRNA3, var("?")) positiveCorrelation path(MESH:"Tobacco Use Disorder") + + + + + + + pubmed:21482353 + + p(HGNC:CHRNA3, var("?")) positiveCorrelation path(MESH:Alcoholism) + + + + + + + pubmed:21482353 + + p(HGNC:CHRNA3, var("?")) positiveCorrelation path(MESH:"Cocaine-Related Disorders") + + + + + + + pubmed:21482353 + + p(HGNC:CHRNA3, var("?")) positiveCorrelation path(MESH:"Opioid-Related Disorders") + + + + + + + pubmed:21482353 + + p(HGNC:CHRNA3, var("?")) positiveCorrelation path(MESH:"Lung Neoplasms") + + + + + + + pubmed:21482353 + + p(HGNC:CHRNA3, var("?")) positiveCorrelation bp(GO:cognition) + + + + + + + pubmed:21482353 + + p(HGNC:CHRNB4, var("?")) positiveCorrelation path(MESH:"Tobacco Use Disorder") + + + + + + + pubmed:21482353 + + p(HGNC:CHRNB4, var("?")) positiveCorrelation path(MESH:Alcoholism) + + + + + + + pubmed:21482353 + + p(HGNC:CHRNB4, var("?")) positiveCorrelation path(MESH:"Cocaine-Related Disorders") + + + + + + + pubmed:21482353 + + p(HGNC:CHRNB4, var("?")) positiveCorrelation path(MESH:"Opioid-Related Disorders") + + + + + + + pubmed:21482353 + + p(HGNC:CHRNB4, var("?")) positiveCorrelation path(MESH:"Lung Neoplasms") + + + + + + + pubmed:21482353 + + p(HGNC:CHRNB4, var("?")) positiveCorrelation bp(GO:cognition) + + + + + + + pubmed:18986241 + + path(MESH:"Behavioral Symptoms") association path(MESH:"Alzheimer Disease") + + + + + + + pubmed:18986241 + + path(CONSO:aMCI) association path(MESH:"Memory Disorders") + + + + + + + pubmed:18986241 + + path(CONSO:aMCI) association path(MESH:Dementia) + + + + + + + pubmed:18986241 + + path(CONSO:aMCI) association path(MESH:"Alzheimer Disease") + + + + + + + pubmed:18986241 + + path(CONSO:mdMCI) association path(MESH:"Cognitive Dysfunction") + + + + + + + pubmed:18986241 + + path(MESH:"Prodromal Symptoms") association path(MESH:"Cognitive Dysfunction") + + + + + + + pubmed:18986241 + + path(MESH:"Cholinergic Neurons") directlyIncreases bp(GO:innervation) + + + + + + + pubmed:18986241 + + path(MESH:"Cholinergic Neurons") association path(MESH:Memory) + + + + + + + pubmed:18986241 + + path(MESH:"Cholinergic Neurons") association path(MESH:Attention) + + + + + + + pubmed:18986241 + + path(MESH:"Cholinergic Neurons") association a(MESH:"Neurofibrillary Tangles") + + + + + + + pubmed:18986241 + + path(MESH:"Cholinergic Neurons") association path(MESH:"Alzheimer Disease") + + + + + + + pubmed:18986241 + + path(MESH:"Cholinergic Neurons") association a(MESH:Neuropeptides) + + + + + + + pubmed:18986241 + + path(MESH:"Cholinergic Neurons") association a(MESH:"GABAergic Neurons") + + + + + + + pubmed:18986241 + + path(MESH:"Cholinergic Neurons") association p(RGD:Gal) + + + + + + + pubmed:18986241 + + path(MESH:"Cholinergic Neurons") association path(MESH:"Memory, Short-Term") + + + + + + + pubmed:18986241 + + path(MESH:"Cholinergic Neurons") association path(MESH:Dementia) + + + + + + + pubmed:18986241 + + bp(GO:innervation) association p(HGNC:NGF) + + + + + + + pubmed:18986241 + + a(MESH:Neuropeptides) association path(MESH:"Cholinergic Neurons") + + + + + + + pubmed:18986241 + + p(RGD:Gal) association path(MESH:"Cholinergic Neurons") + + + + + + + pubmed:18986241 + + a(MESH:"Frontal Lobe") positiveCorrelation path(MESH:"Psychomotor Performance") + + + + + + + pubmed:28669544 + + a(MESH:"Frontal Lobe") negativeCorrelation path(OMIT:0026893) + + + + + + + pubmed:18986241 + + p(HGNC:BCHE, var("p.Ala539Thr")) decreases p(HGNC:BCHE) + + + + + + + pubmed:18986241 + + p(HGNC:BCHE, var("p.Ala539Thr")) association path(MESH:"Cognitive Dysfunction") + + + + + + + pubmed:18986241 + + complex(p(HGNC:NGF), p(HGNC:NTRK1)) increases bp(GO:"nerve growth factor signaling pathway") + + + + + + + pubmed:18986241 + + complex(p(HGNC:NGF), p(HGNC:NTRK1)) increases bp(GO:"neuron projection development") + + + + + + + pubmed:18986241 + + bp(GO:"nerve growth factor signaling pathway") increases bp(GO:"response to nerve growth factor") + + + + + + + pubmed:18986241 + + bp(GO:"regulation of neuron death") association p(HGNC:NGFR) + + + + + + + + + pubmed:18986241 + + a(MESH:"pro-nerve growth factor, human") positiveCorrelation path(MESH:"Cognition Disorders") + + + + + + + pubmed:18986241 + + a(MESH:"pro-nerve growth factor, human") biomarkerFor path(MESH:"Alzheimer Disease") + + + + + + + + + + + pubmed:18986241 + + complex(a(MESH:"pro-nerve growth factor, human"), p(HGNC:NTRK1)) increases bp(GO:"neuron projection development") + + + + + + + pubmed:18986241 + + complex(a(MESH:"pro-nerve growth factor, human"), p(HGNC:NGFR)) increases bp(GO:"apoptotic process") + + + + + + + pubmed:18986241 + + composite(a(MESH:"pro-nerve growth factor, human"), complex(p(HGNC:NGFR), p(HGNC:SORT1))) increases bp(GO:"apoptotic process") + + + + + + + + + + + pubmed:18986241 + + p(HGNC:SORT1) association path(MESH:"Alzheimer Disease") + + + + + + + pubmed:18986241 + + act(p(HGNC:MMP9)) positiveCorrelation path(MESH:"Cognition Disorders") + + + + + + + pubmed:27594586 + + p(HGNC:MMP9) increases p(HGNC:HTT, frag("?")) + + + + + + + pubmed:27594586 + + act(p(HGNC:MMP9)) association path(MESH:"Neurodevelopmental Disorders") + + + + + + + pubmed:27594586 + + act(p(HGNC:MMP9)) increases bp(GO:"neuron death") + + + + + + + pubmed:27594586 + + p(HGNC:MMP9) increases bp(GO:"neuron death") + + + + + + + pubmed:27594586 + + act(p(HGNC:MMP9)) positiveCorrelation p(FPLX:ERK, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:27594586 + + tloc(p(HGNC:MMP9), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) positiveCorrelation p(FPLX:ERK, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:26195256 + + p(HGNC:MMP9) increases deg(a(CHEBI:amyloid-beta, loc(GO:"extracellular region"))) + + + + + + + pubmed:29626319 + + act(p(HGNC:MMP9)) increases deg(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:29626319 + + p(HGNC:MMP9) increases deg(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:18986241 + + g(HGNC:NTRK1) association path(MESH:Cognition) + + + + + + + pubmed:18986241 + + g(HGNC:NTRK2) association path(MESH:Cognition) + + + + + + + pubmed:27013968 + + g(HGNC:NTRK2) increases p(HGNC:NTRK2) + + + + + + + pubmed:18986241 + + g(HGNC:NTRK3) association path(MESH:Cognition) + + + + + + + pubmed:18986241 + + act(p(HGNC:MAPKAPK2)) increases p(HGNC:ELK1, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:18986241 + + act(p(HGNC:MAPKAPK2)) increases p(HGNC:CREB1, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + + + pubmed:18986241 + + p(HGNC:IRS1) association bp(GO:"phosphatidylinositol 3-kinase signaling") + + + + + + + pubmed:18986241 + + p(HGNC:IRS1) association bp(GO:"protein kinase B signaling") + + + + + + + + + + + + + + + pubmed:18986241 + + p(HGNC:GAB1) association bp(GO:"phosphatidylinositol 3-kinase signaling") + + + + + + + pubmed:18986241 + + p(HGNC:GAB1) association bp(GO:"protein kinase B signaling") + + + + + + + pubmed:18986241 + + act(p(HGNC:PLCG1)) association bp(MESH:"Oxidative Stress") + + + + + + + + + + + pubmed:18467332 + + p(HGNC:PLCG1) isA complex(p(HGNC:MAPT), p(HGNC:PLCG1)) + + + + + + + pubmed:18986241 + + complex(a(MESH:"gambogic amide"), p(HGNC:NTRK1)) directlyIncreases p(HGNC:NTRK1, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + + + pubmed:18986241 + + a(MESH:"gambogic amide") decreases path(CONSO:Excitotoxicity) + + + + + + + pubmed:18986241 + + a(MESH:"gambogic amide") increases bp(GO:"neuron projection development") + + + + + + + pubmed:18986241 + + p(HGNC:NTRK1, pmod(go:0006468 ! "protein phosphorylation")) increases bp(GO:"protein kinase B signaling") + + + + + + + pubmed:18986241 + + p(HGNC:NTRK1, pmod(go:0006468 ! "protein phosphorylation")) increases bp(GO:"MAPK cascade") + + + + + + + pubmed:18986241 + + path(MESH:Amyloidosis) association p(HGNC:CHRM1) + + + + + + + pubmed:26751493 + + r(HGNC:SYP) negativeCorrelation a(GO:"neurofibrillary tangle") + + + + + + + pubmed:18986241 + + p(HGNCGENEFAMILY:Synaptotagmins) association bp(GO:"synaptic vesicle fusion to presynaptic active zone membrane") + + + + + + + pubmed:18986241 + + p(HGNCGENEFAMILY:Synaptotagmins) association bp(GO:"neurotransmitter secretion") + + + + + + + pubmed:18986241 + + bp(GO:"synaptic vesicle fusion to presynaptic active zone membrane") association p(HGNCGENEFAMILY:Synaptotagmins) + + + + + + + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform B (381 aa)") increases a(CONSO:"Tau oligomers") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform B (381 aa)") positiveCorrelation p(CONSO:"phosphatase-activating domain") + + + + + + + pubmed:17493042 + + p(CONSO:"Tau isoform B (381 aa)") partOf a(MESH:Brain) + + + + + + + pubmed:23407988 + + p(CONSO:"Tau isoform B (381 aa)") isA p(CONSO:"3R tau") + + + + + + + + + + + + + + + pubmed:28148553 + + p(CONSO:"Tau isoform C (410 aa)") directlyIncreases p(CONSO:"3R tau") + + + + + + + pubmed:23407988 + + p(CONSO:"Tau isoform C (410 aa)") isA p(CONSO:"3R tau") + + + + + + + pubmed:28148553 + + p(CONSO:"Tau isoform C (410 aa)") causesNoChange p(HGNC:EIF2AK3) + + + + + + + pubmed:28148553 + + p(CONSO:"Tau isoform C (410 aa)") causesNoChange p(HGNC:EIF2AK3, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:28148553 + + p(CONSO:"Tau isoform C (410 aa)") causesNoChange p(HGNC:EIF2A) + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform C (410 aa)") association p(CONSO:"phosphatase-activating domain") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform C (410 aa)") positiveCorrelation p(CONSO:"phosphatase-activating domain") + + + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform C (410 aa)") increases a(CONSO:"Tau oligomers") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform C (410 aa)") increases a(CONSO:"Tau oligomers") + + + + + + + pubmed:17493042 + + p(CONSO:"Tau isoform C (410 aa)") partOf a(MESH:Brain) + + + + + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform D (383 aa)") association p(CONSO:"phosphatase-activating domain") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform D (383 aa)") positiveCorrelation p(CONSO:"phosphatase-activating domain") + + + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform D (383 aa)") increases a(CONSO:"Tau oligomers") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform D (383 aa)") increases a(CONSO:"Tau oligomers") + + + + + + + + + + + + + + + + + + + + + + + pubmed:17493042 + + p(CONSO:"Tau isoform D (383 aa)") partOf a(MESH:Brain) + + + + + + + pubmed:23407988 + + p(CONSO:"Tau isoform D (383 aa)") isA p(CONSO:"4R tau") + + + + + + + + + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform E (412 aa)") increases a(CONSO:"Tau oligomers") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform E (412 aa)") positiveCorrelation p(CONSO:"phosphatase-activating domain") + + + + + + + + + + + pubmed:17493042 + + p(CONSO:"Tau isoform E (412 aa)") partOf a(MESH:Brain) + + + + + + + pubmed:23407988 + + p(CONSO:"Tau isoform E (412 aa)") isA p(CONSO:"4R tau") + + + + + + + + + + + + + + + + + + + + + + + pubmed:28148553 + + p(CONSO:"Tau isoform F (441 aa)") directlyIncreases p(CONSO:"4R tau") + + + + + + + pubmed:23407988 + + p(CONSO:"Tau isoform F (441 aa)") isA p(CONSO:"4R tau") + + + + + + + pubmed:28148553 + + p(CONSO:"Tau isoform F (441 aa)") causesNoChange p(HGNC:EIF2AK3) + + + + + + + pubmed:28148553 + + p(CONSO:"Tau isoform F (441 aa)") causesNoChange p(HGNC:EIF2AK3, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:28148553 + + p(CONSO:"Tau isoform F (441 aa)") decreases p(HGNC:EIF2A) + + + + + + + pubmed:28148553 + + p(CONSO:"Tau isoform F (441 aa)") increases p(CONSO:"Tau epitope, CP13") + + + + + + + pubmed:28148553 + + p(CONSO:"Tau isoform F (441 aa)") increases p(CONSO:"Tau epitope, AD2") + + + + + + + pubmed:28148553 + + p(CONSO:"Tau isoform F (441 aa)") increases a(CONSO:"Tau antibody, HT7") + + + + + + + pubmed:28148553 + + p(CONSO:"Tau isoform F (441 aa)") causesNoChange a(CONSO:"Tau antibody, MC1") + + + + + + + + + + + pubmed:30606258 + + p(CONSO:"Tau isoform F (441 aa)") increases bp(GO:"microtubule bundle formation") + + + + + + + + + pubmed:30606258 + + p(CONSO:"Tau isoform F (441 aa)") increases composite(a(GO:"microtubule bundle"), p(CONSO:"Tau isoform F (441 aa)")) + + + + + + + + + pubmed:30606258 + + p(CONSO:"Tau isoform F (441 aa)") directlyIncreases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation", Lys, 40)) + + + + + + + pubmed:30606258 + + p(CONSO:"Tau isoform F (441 aa)") increases bp(GO:"microtubule cytoskeleton organization") + + + + + + + + + + + + + + + pubmed:30606258 + + p(CONSO:"Tau isoform F (441 aa)") increases p(HGNC:AKT1) + + + + + + + pubmed:30606258 + + p(CONSO:"Tau isoform F (441 aa)") increases act(p(HGNC:AKT1)) + + + + + + + pubmed:30606258 + + p(CONSO:"Tau isoform F (441 aa)") increases act(p(HGNC:AKT1)) + + + + + + + pubmed:30606258 + + p(CONSO:"Tau isoform F (441 aa)") increases p(HGNC:AKT1, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:30606258 + + p(CONSO:"Tau isoform F (441 aa)") decreases p(HGNC:GSK3B) + + + + + + + + + pubmed:30606258 + + p(CONSO:"Tau isoform F (441 aa)") decreases p(HGNC:ATF6, frag("?")) + + + + + + + pubmed:30606258 + + p(CONSO:"Tau isoform F (441 aa)") decreases bp(GO:"ATF6-mediated unfolded protein response") + + + + + + + pubmed:30606258 + + p(CONSO:"Tau isoform F (441 aa)") causesNoChange p(HGNC:ERN1, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:30606258 + + p(CONSO:"Tau isoform F (441 aa)") causesNoChange bp(GO:"IRE1-mediated unfolded protein response") + + + + + + + pubmed:30606258 + + p(CONSO:"Tau isoform F (441 aa)") causesNoChange p(HGNCGENEFAMILY:"CCAAT/enhancer binding proteins") + + + + + + + + + + + + + + + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform F (441 aa)") positiveCorrelation path(MESH:"Protein Aggregation, Pathological") + + + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform F (441 aa)") increases a(CONSO:"Tau oligomers") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform F (441 aa)") positiveCorrelation p(CONSO:"phosphatase-activating domain") + + + + + + + + + + + + + pubmed:29191965 + + p(CONSO:"Tau isoform F (441 aa)") decreases bp(GO:"anterograde axonal transport of mitochondrion") + + + + + + + pubmed:29191965 + + p(CONSO:"Tau isoform F (441 aa)") decreases bp(GO:"retrograde axonal transport of mitochondrion") + + + + + + + pubmed:29686391 + + tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) positiveCorrelation p(CONSO:"Tau isoform F (441 aa)") + + + + + + + pubmed:29686391 + + p(CONSO:"Tau isoform F (441 aa)") positiveCorrelation tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:29686391 + + p(CONSO:"Tau isoform F (441 aa)") increases tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + + + + + pubmed:29686391 + + tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) negativeCorrelation a(CHEBI:heparin) + + + + + + + pubmed:29686391 + + tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) positiveCorrelation a(CONSO:"6-O-sulfated heparin") + + + + + + + + + + + pubmed:25374103 + + p(CONSO:"Tau isoform F (441 aa)") causesNoChange bp(GO:"cell death") + + + + + + + pubmed:25374103 + + p(CONSO:"Tau isoform F (441 aa)") increases act(p(HGNC:CASP3)) + + + + + + + + + pubmed:25374103 + + p(CONSO:"Tau isoform F (441 aa)") decreases bp(GO:"mitochondrion transport along microtubule") + + + + + + + pubmed:25374103 + + p(CONSO:"Tau isoform F (441 aa)") decreases bp(GO:"mitochondrion transport along microtubule") + + + + + + + pubmed:17493042 + + p(CONSO:"Tau isoform F (441 aa)") partOf a(MESH:Brain) + + + + + + + + + + + + + + + + + + + + + + + + + pubmed:30145931 + + r(HGNC:MAPT, loc(MESH:Dendrites)) increases p(HGNC:MAPT, loc(MESH:Dendrites)) + + + + + + + + + pubmed:18986241 + + act(p(HGNC:GAL)) association path(MESH:Cognition) + + + + + + + pubmed:18986241 + + act(p(HGNC:GAL)) association bp(MESH:"Neuronal Plasticity") + + + + + + + pubmed:18986241 + + act(p(HGNC:GAL)) increases bp(GO:innervation) + + + + + + + pubmed:18986241 + + act(p(HGNC:GAL)) regulates act(a(MESH:"Cholinergic Neurons")) + + + + + + + pubmed:18986241 + + act(p(HGNC:GAL)) decreases a(CHEBI:amyloid-beta) + + + + + + + pubmed:18986241 + + act(p(HGNC:GAL)) increases r(HGNC:CHAT) + + + + + + + pubmed:18986241 + + act(p(HGNC:GAL)) causesNoChange p(CONSO:"Tau MN423") + + + + + + + pubmed:18986241 + + act(p(HGNC:GAL)) increases r(HGNC:PPP1CA) + + + + + + + pubmed:18986241 + + act(p(HGNC:GAL)) increases r(HGNC:PPP1CC) + + + + + + + pubmed:18986241 + + p(CONSO:"Tau C3") biomarkerFor act(a(MESH:"Cholinergic Neurons")) + + + + + + + pubmed:24027553 + + p(CONSO:"Tau C3") increases bp(GO:"apoptotic process") + + + + + + + pubmed:24027553 + + p(CONSO:"Tau C3") increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:24027553 + + p(CONSO:"Tau C3") increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:24027553 + + p(CONSO:"Tau C3") negativeCorrelation bp(GO:cognition) + + + + + + + pubmed:24027553 + + p(CONSO:"Tau C3") association path(MESH:"Neurofibrillary Tangles") + + + + + + + + + + + pubmed:25374103 + + p(CONSO:"Tau C3") causesNoChange bp(GO:"cell death") + + + + + + + pubmed:25374103 + + p(CONSO:"Tau C3") increases act(p(HGNC:CASP3)) + + + + + + + pubmed:25374103 + + p(CONSO:"Tau C3") decreases bp(GO:"mitochondrion transport along microtubule") + + + + + + + pubmed:25374103 + + p(CONSO:"Tau C3") decreases bp(GO:"mitochondrion transport along microtubule") + + + + + + + pubmed:18986241 + + p(RGD:Ngf) increases r(RGD:Gal) + + + + + + + pubmed:18986241 + + p(RGD:Ngf) decreases path(MESH:"Cognitive Dysfunction") + + + + + + + pubmed:18986241 + + bp(GO:"amyloid-beta metabolic process") association a(MESH:"Cholinesterase Inhibitors") + + + + + + + pubmed:29758300 + + bp(GO:"amyloid-beta metabolic process") association a(CHEBI:sphingolipid) + + + + + + + pubmed:18986241 + + path(MESH:Anorexia) association a(MESH:"Cholinesterase Inhibitors") + + + + + + + pubmed:18986241 + + bp(GO:"sympathetic nervous system development") association p(HGNC:NGF) + + + + + + + pubmed:18986241 + + path(MESH:Cachexia) association p(HGNC:NGF) + + + + + + + pubmed:14556719 + + path(MESH:Cachexia) increases bp(GO:"protein catabolic process") + + + + + + + pubmed:18986241 + + path(MESH:Hyperalgesia) association p(HGNC:NGF) + + + + + + + pubmed:18986241 + + g(HGNC:NGF) directlyIncreases p(HGNC:NGF) + + + + + + + pubmed:18986241 + + a(MESH:latrepirdine) decreases act(p(HGNC:BCHE)) + + + + + + + pubmed:18986241 + + a(MESH:latrepirdine) decreases act(p(HGNC:ACHE)) + + + + + + + pubmed:18986241 + + a(MESH:latrepirdine) decreases bp(GO:"NMDA selective glutamate receptor signaling pathway") + + + + + + + pubmed:18986241 + + a(MESH:latrepirdine) decreases bp(GO:"regulation of mitochondrial membrane permeability") + + + + + + + pubmed:18986241 + + a(MESH:latrepirdine) increases bp(MESH:Neuroprotection) + + + + + + + pubmed:11230871 + + a(MESH:"Neurotransmitter Agents") association p(FPLX:CHRN) + + + + + + + pubmed:11230871 + + path(MESH:"Tourette Syndrome") association p(FPLX:CHRN) + + + + + + + + + + + pubmed:28901280 + + a(CHEBI:cytisine) increases p(MESH:"Receptors, Nicotinic") + + + + + + + pubmed:11230871 + + complex(CONSO:"alpha-4-containing nAChR") negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:11230871 + + complex(CONSO:"alpha-7-containing nAChR") negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:11230871 + + complex(CONSO:"alpha-7-containing nAChR") negativeCorrelation path(MESH:Schizophrenia) + + + + + + + pubmed:11230871 + + complex(CONSO:"alpha-7-containing nAChR") regulates act(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:11230871 + + a(PUBCHEM:5662) association bp(GO:"synaptic transmission, cholinergic") + + + + + + + pubmed:11230871 + + a(PUBCHEM:132228) increases p(FPLX:CHRN) + + + + + + + pubmed:11230871 + + a(CHEBI:Ondansetron) decreases p(FPLX:CHRN) + + + + + + + pubmed:11230871 + + a(PUBCHEM:119380) increases path(MESH:"Verbal Learning") + + + + + + + pubmed:11230871 + + a(PUBCHEM:119380) increases bp(GO:memory) + + + + + + + pubmed:28132910 + + a(CONSO:B-973) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + + + + + + + pubmed:28132910 + + a(CONSO:B-973) negativeCorrelation act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + + + + + + + pubmed:28132910 + + a(CONSO:B-973) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + + + + + + + pubmed:28132910 + + a(CONSO:B-973) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + + + + + + + pubmed:28132910 + + a(CONSO:B-973) increases act(a(CHEBI:acetylcholine)) + + + + + + + pubmed:28132910 + + a(CONSO:B-973) increases act(p(HGNC:CHRNA7)) + + + + + + + pubmed:28132910 + + a(CONSO:B-973) increases complex(a(GO:membrane), a(PUBCHEM:16068384)) + + + + + + + pubmed:28132910 + + a(CONSO:B-973) increases complex(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"), a(PUBCHEM:16068384)) + + + + + + + pubmed:28132910 + + a(CONSO:B-973) increases complex(a(PUBCHEM:16068384), p(MGI:Chrna7)) + + + + + + + + + + + + + + + pubmed:28132910 + + a(PUBCHEM:5288811) decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + + + + + + + pubmed:28391535 + + a(PUBCHEM:5288811) decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + + + + + + + pubmed:28391535 + + a(PUBCHEM:5288811) decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + + + + + + + pubmed:28391535 + + a(PUBCHEM:5288811) causesNoChange act(a(CHEBI:nicotine)) + + + + + + + pubmed:28391535 + + a(PUBCHEM:5288811) causesNoChange act(a(CHEBI:nicotine)) + + + + + + + pubmed:17640819 + + composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu")), p(MGI:Psen1, var("p.Met146Leu"))) increases a(CHEBI:amyloid-beta) + + + + + + + + + + + pubmed:25881725 + + a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") decreases act(p(MGI:App, frag("25_35"))) + + + + + + + pubmed:25881725 + + a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") decreases act(p(MGI:App, frag("25_35"))) + + + + + + + pubmed:25881725 + + a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases bp(GO:learning) + + + + + + + pubmed:25881725 + + a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases bp(GO:learning) + + + + + + + pubmed:25881725 + + a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases path(MESH:"Spatial Memory") + + + + + + + pubmed:25881725 + + a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases path(MESH:"Spatial Memory") + + + + + + + pubmed:25881725 + + a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") causesNoChange r(MGI:Chrna7) + + + + + + + pubmed:25881725 + + a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases p(MGI:Chrna7) + + + + + + + pubmed:25881725 + + a(MESH:"N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide") increases p(MGI:Chrna7) + + + + + + + pubmed:19721446 + + a(MESH:"Peripheral Nervous System") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + + + + + + + pubmed:19721446 + + a(MESH:"Central Nervous System") association p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") + + + + + + + pubmed:30988501 + + act(a(MESH:"Central Nervous System")) association bp(GO:"cytokine secretion") + + + + + + + pubmed:19721446 + + bp(GO:"regulation of cation channel activity") association a(CHEBI:acetylcholine) + + + + + + + pubmed:19721446 + + p(HGNC:CHRNA7, frag("231_255")) association act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) + + + + + + + pubmed:19721446 + + p(HGNC:CHRNA7, frag("231_255")) association act(a(PUBCHEM:11964458)) + + + + + + + pubmed:19721446 + + act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) association p(HGNC:CHRNA7, frag("231_255")) + + + + + + + pubmed:19721446 + + act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) association p(HGNC:CHRNA7, frag("262_280")) + + + + + + + pubmed:19721446 + + act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) association p(HGNC:CHRNA7, frag("470_490")) + + + + + + + pubmed:19721446 + + p(HGNC:CHRNA7, frag("262_280")) association act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) + + + + + + + pubmed:19721446 + + p(HGNC:CHRNA7, frag("262_280")) association act(a(PUBCHEM:11964458)) + + + + + + + pubmed:19721446 + + p(HGNC:CHRNA7, frag("470_490")) association act(a(MESH:"1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea")) + + + + + + + pubmed:19721446 + + p(HGNC:CHRNA7, frag("470_490")) association act(a(PUBCHEM:11964458)) + + + + + + + pubmed:19721446 + + act(a(PUBCHEM:11964458)) association p(HGNC:CHRNA7, frag("231_255")) + + + + + + + pubmed:19721446 + + act(a(PUBCHEM:11964458)) association p(HGNC:CHRNA7, frag("262_280")) + + + + + + + pubmed:19721446 + + act(a(PUBCHEM:11964458)) association p(HGNC:CHRNA7, frag("470_490")) + + + + + + + pubmed:19721446 + + p(HGNC:CHRNA4, frag("331_600")) association p(HGNC:YWHAH) + + + + + + + pubmed:19721446 + + p(HGNC:CHRNA4, frag("331_600")) association p(HGNC:VSNL1) + + + + + + + pubmed:19721446 + + p(HGNC:YWHAH) association p(HGNC:CHRNA4, frag("331_600")) + + + + + + + pubmed:19721446 + + p(HGNCGENEFAMILY:Tubulins) association p(HGNC:CHRNB2) + + + + + + + + + pubmed:19721446 + + p(HGNCGENEFAMILY:"Clathrin subunits") association p(HGNC:CHRNB2) + + + + + + + + + pubmed:19721446 + + a(MESH:"AR-R 17779") increases bp(GO:learning) + + + + + + + pubmed:19721446 + + a(MESH:"AR-R 17779") increases bp(GO:memory) + + + + + + + pubmed:19721446 + + a(MESH:"AR-R 17779") decreases act(a(CHEBI:scopolamine)) + + + + + + + pubmed:19721446 + + a(DRUGBANK:Facinicline) increases bp(GO:cognition) + + + + + + + pubmed:19721446 + + a(DRUGBANK:Facinicline) increases bp(GO:memory) + + + + + + + pubmed:19721446 + + a(DRUGBANK:Facinicline) increases path(MESH:"Memory, Episodic") + + + + + + + pubmed:19721446 + + a(MESH:"alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid") increases path(CONSO:neurotoxicity) + + + + + + + pubmed:19721446 + + a(MESH:"Entorhinal Cortex") association bp(GO:memory) + + + + + + + pubmed:19721446 + + path(MESH:"Attention Deficit Disorder with Hyperactivity") association a(MESH:"3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole") + + + + + + + pubmed:19721446 + + path(MESH:"Attention Deficit Disorder with Hyperactivity") association a(MESH:pozanicline) + + + + + + + pubmed:19721446 + + a(MESH:pozanicline) association path(MESH:"Attention Deficit Disorder with Hyperactivity") + + + + + + + pubmed:19721446 + + a(MESH:Dihydro-beta-Erythroidine) decreases act(a(CHEBI:nicotine)) + + + + + + + pubmed:28391535 + + a(MESH:Dihydro-beta-Erythroidine) decreases act(a(CHEBI:nicotine)) + + + + + + + pubmed:28391535 + + a(MESH:Dihydro-beta-Erythroidine) decreases act(a(CHEBI:nicotine)) + + + + + + + pubmed:19721446 + + a(MESH:Dihydro-beta-Erythroidine) decreases act(p(CONSO:"alpha-4 beta-2 nAChR")) + + + + + + + pubmed:28901280 + + a(MESH:Dihydro-beta-Erythroidine) increases p(MESH:"Receptors, Nicotinic") + + + + + + + + + pubmed:28391535 + + a(MESH:Dihydro-beta-Erythroidine) increases complex(a(MESH:"nicotinic receptor alpha4beta2"), a(MESH:Dihydro-beta-Erythroidine)) + + + + + + + pubmed:28391535 + + a(MESH:Dihydro-beta-Erythroidine) decreases act(a(MESH:"Receptors, Nicotinic")) + + + + + + + pubmed:28391535 + + a(MESH:Dihydro-beta-Erythroidine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + + + + + + + + + pubmed:28391535 + + a(MESH:Dihydro-beta-Erythroidine) increases complex(a(MESH:Dihydro-beta-Erythroidine), p(HGNC:CHRNB2)) + + + + + + + pubmed:28391535 + + a(MESH:Dihydro-beta-Erythroidine) decreases act(a(MESH:"nicotinic receptor alpha3beta2")) + + + + + + + pubmed:28391535 + + a(MESH:Dihydro-beta-Erythroidine) decreases act(a(MESH:"nicotinic receptor alpha4beta2")) + + + + + + + pubmed:28391535 + + a(MESH:Dihydro-beta-Erythroidine) decreases act(a(MESH:"nicotinic receptor alpha3beta4")) + + + + + + + pubmed:28391535 + + a(MESH:Dihydro-beta-Erythroidine) decreases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + + + + + + + pubmed:19721446 + + a(CHEBI:varenicline) increases path(MESH:"Smoking Cessation") + + + + + + + pubmed:28391535 + + a(CHEBI:varenicline) association path(MESH:"Smoking Cessation") + + + + + + + pubmed:19721446 + + a(CHEBI:varenicline) increases act(p(CONSO:"alpha-4 beta-2 nAChR")) + + + + + + + pubmed:19721446 + + a(CHEBI:varenicline) increases act(p(HGNC:CHRNA7)) + + + + + + + pubmed:28391535 + + a(CHEBI:varenicline) increases act(a(MESH:"nicotinic receptor alpha4beta2")) + + + + + + + pubmed:28391535 + + a(CHEBI:varenicline) increases act(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) + + + + + + + pubmed:19721446 + + complex(p(HGNC:CHRNA4), p(HGNC:CHRNA6), p(HGNC:CHRNB2), p(HGNC:CHRNB3)) association a(MESH:"Dopaminergic Neurons") + + + + + + + pubmed:19721446 + + complex(p(HGNC:CHRNA6), p(HGNC:CHRNB2), p(HGNC:CHRNB3)) association a(MESH:"Dopaminergic Neurons") + + + + + + + pubmed:19721446 + + complex(p(HGNC:CHRNA6), p(HGNC:CHRNB2)) association a(MESH:"Dopaminergic Neurons") + + + + + + + pubmed:19721446 + + g(HGNC:CHRNA5) association path(MESH:"Lung Neoplasms") + + + + + + + pubmed:19721446 + + g(HGNC:CHRNA3) association path(MESH:"Lung Neoplasms") + + + + + + + pubmed:19721446 + + g(HGNC:CHRNB4) association path(MESH:"Lung Neoplasms") + + + + + + + pubmed:19721446 + + a(CHEBI:sertraline) decreases a(CHEBI:monoamine) + + + + + + + pubmed:19721446 + + a(CHEBI:sertraline) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + + + + + + + pubmed:19721446 + + a(CHEBI:paroxetine) decreases a(CHEBI:monoamine) + + + + + + + pubmed:19721446 + + a(CHEBI:paroxetine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + + + + + + + pubmed:19721446 + + a(CHEBI:nefazodone) decreases a(CHEBI:monoamine) + + + + + + + pubmed:19721446 + + a(CHEBI:nefazodone) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + + + + + + + pubmed:19721446 + + a(CHEBI:nisoxetine) decreases a(CHEBI:monoamine) + + + + + + + pubmed:19721446 + + a(CHEBI:nisoxetine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + + + + + + + pubmed:19721446 + + a(CHEBI:nomifensine) decreases a(CHEBI:monoamine) + + + + + + + pubmed:19721446 + + a(CHEBI:nomifensine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + + + + + + + pubmed:19721446 + + a(CHEBI:vanoxerine) decreases a(CHEBI:monoamine) + + + + + + + pubmed:19721446 + + a(CHEBI:vanoxerine) decreases act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) + + + + + + + pubmed:19721446 + + a(MESH:"5-(2-azetidinylmethoxy)-2-chloropyridine") increases act(p(CONSO:"alpha-4 beta-2 nAChR")) + + + + + + + pubmed:19721446 + + a(MESH:"5-(2-azetidinylmethoxy)-2-chloropyridine") association path(MESH:Vomiting) + + + + + + + pubmed:19721446 + + a(MESH:"5-(2-azetidinylmethoxy)-2-chloropyridine") association path(MESH:Nausea) + + + + + + + pubmed:19721446 + + a(MESH:"5-(2-azetidinylmethoxy)-2-chloropyridine") increases act(complex(p(HGNC:CHRNA3), p(HGNC:CHRNB4))) + + + + + + + pubmed:19721446 + + a(MESH:"3-(5,6-dichloropyridin-3-yl)-3,6-diazabicyclo(3.2.0)heptane") increases act(p(CONSO:"alpha-4 beta-2 nAChR")) + + + + + + + pubmed:19721446 + + complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) association a(MESH:Conotoxins) + + + + + + + pubmed:19721446 + + complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) increases act(a(MESH:Lymphocytes)) + + + + + + + pubmed:28901280 + + complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) increases p(MESH:"Receptors, Nicotinic") + + + + + + + pubmed:28901280 + + path(MESH:Pain) association p(MESH:"Receptors, Nicotinic") + + + + + + + pubmed:22040696 + + p(FPLX:Cyclophilin) increases p(HGNC:CHRNA7) + + + + + + + pubmed:22040696 + + p(HGNC:CANX) increases p(FPLX:CHRN) + + + + + + + pubmed:22040696 + + composite(p(HGNC:HTR3A), p(HGNC:RIC3)) decreases tloc(p(HGNC:HTR3A), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) + + + + + + + + + + + pubmed:22040696 + + p(UNIPROT:P34371) increases act(p(FPLX:CHRN)) + + + + + + + pubmed:22040696 + + p(FPLX:CHRN, pmod(go:0006468 ! "protein phosphorylation", Tyr)) decreases act(p(FPLX:CHRN)) + + + + + + + pubmed:22040696 + + complex(p(FPLX:CHRN), p(FPLX:SRC)) increases bp(GO:"catecholamine secretion") + + + + + + + pubmed:22040696 + + complex(p(FPLX:CHRN), p(HGNC:FYN)) increases bp(GO:"catecholamine secretion") + + + + + + + pubmed:22040696 + + complex(p(HGNC:CHRNA7), p(HGNC:FYN)) increases act(p(FPLX:PI3K)) + + + + + + + pubmed:22040696 + + complex(p(HGNC:CHRNA7), p(HGNC:JAK2)) increases act(p(FPLX:PI3K)) + + + + + + + pubmed:21787755 + + bp(GO:"maintenance of synapse structure") association p(CONSO:"alpha-7-containing nAChR") + + + + + + + pubmed:22040696 + + act(a(MESH:"SNARE Proteins")) increases tloc(p(HGNC:CHRNA7), fromLoc(GO:"cell surface"), toLoc(GO:endosome)) + + + + + + + pubmed:22040696 + + act(a(MESH:"SNARE Proteins")) causesNoChange tloc(p(HGNC:CHRNA7), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) + + + + + + + pubmed:22040696 + + p(HGNC:CHRNA7, var("p.Leu335Ala")) decreases tloc(p(HGNC:CHRNA7), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) + + + + + + + pubmed:22040696 + + p(HGNC:CHRNA7, var("p.Leu336Ala")) decreases tloc(p(HGNC:CHRNA7), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) + + + + + + + pubmed:22040696 + + p(HGNC:CHRNA7, var("p.Leu343Ala")) decreases tloc(p(HGNC:CHRNA7), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) + + + + + + + pubmed:22040696 + + r(HGNC:RIC3) positiveCorrelation path(MESH:Schizophrenia) + + + + + + + pubmed:22040696 + + r(HGNC:RIC3) positiveCorrelation path(MESH:"Bipolar Disorder") + + + + + + + pubmed:22040696 + + path(MESH:"Bipolar Disorder") positiveCorrelation r(HGNC:RIC3) + + + + + + + pubmed:22040696 + + path(MESH:"Bipolar Disorder") negativeCorrelation act(p(HGNC:RIC3), ma(go:0044183 ! "protein binding involved in protein folding")) + + + + + + + pubmed:30740335 + + path(MESH:"Bipolar Disorder") association p(DBSNP:rs2269577) + + + + + + + pubmed:22040696 + + bp(GO:"response to ischemia") increases path(MESH:"Renal Insufficiency") + + + + + + + pubmed:18174175 + + complex(a(CHEBI:epibatidine), p(CONSO:"alpha-3 beta-2 nAChR")) increases act(p(CONSO:"alpha-3 beta-2 nAChR")) + + + + + + + pubmed:26837465 + + composite(p(GO:"neurofibrillary tangle"), p(HGNC:ESR1)) association composite(p(GO:"neurofibrillary tangle"), p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) + + + + + + + pubmed:26837465 + + composite(p(GO:"neurofibrillary tangle"), p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) association composite(p(GO:"neurofibrillary tangle"), p(HGNC:ESR1)) + + + + + + + pubmed:21787755 + + bp(GO:"neuron projection maintenance") association p(CONSO:"alpha-7-containing nAChR") + + + + + + + pubmed:21787755 + + composite(a(CHEBI:nicotine), p(CONSO:"alpha-4-containing nAChR")) increases complex(a(CHEBI:nicotine), p(CONSO:"alpha-4-containing nAChR")) + + + + + + + pubmed:21787755 + + composite(p(HGNC:CHRNA4), p(HGNC:CHRNB4)) increases p(CONSO:"alpha-4 beta-4 nAChR") + + + + + + + + + + + pubmed:21787755 + + composite(a(CHEBI:nicotine), p(CONSO:"alpha-4 beta-4 nAChR")) increases complex(a(CHEBI:nicotine), p(CONSO:"alpha-4 beta-4 nAChR")) + + + + + + + pubmed:21787755 + + composite(r(HGNC:CHRNA4), r(HGNC:CHRNB4)) association path(MESH:"Tobacco Use Disorder") + + + + + + + + + pubmed:21787755 + + path(MESH:Pleasure) association p(CONSO:"alpha-6-containing nAChR") + + + + + + + pubmed:21787755 + + a(MESH:"neuronal bungarotoxin") decreases act(p(CONSO:"alpha-3 beta-2 nAChR")) + + + + + + + pubmed:21787755 + + a(MESH:"neuronal bungarotoxin") decreases act(p(CONSO:"alpha-6-containing nAChR")) + + + + + + + pubmed:21787755 + + p(CONSO:kappa-Bungarotoxin) decreases act(p(CONSO:"alpha-3 beta-2 nAChR")) + + + + + + + pubmed:21787755 + + p(CONSO:kappa-Bungarotoxin) decreases act(p(CONSO:"alpha-6-containing nAChR")) + + + + + + + pubmed:21787755 + + a(MESH:"alpha-conotoxin PnIA") decreases act(p(CONSO:"alpha-3 beta-2 nAChR")) + + + + + + + pubmed:21787755 + + a(MESH:"alpha-conotoxin PnIA") decreases act(p(CONSO:"alpha-6-containing nAChR")) + + + + + + + pubmed:21787755 + + bp(MESH:"Drug Interactions") association r(HGNC:CHRNA6) + + + + + + + pubmed:21787755 + + bp(MESH:"Drug Interactions") association p(HGNC:CHRNA6) + + + + + + + pubmed:28901280 + + composite(a(MESH:Acetylcholine), p(MESH:"Receptors, Nicotinic")) increases complex(a(MESH:Acetylcholine), p(MESH:"Receptors, Nicotinic")) + + + + + + + pubmed:28901280 + + complex(a(MESH:Acetylcholine), p(MESH:"Receptors, Nicotinic")) increases act(a(MESH:"Peripheral Nervous System")) + + + + + + + pubmed:28901280 + + complex(a(MESH:Acetylcholine), p(MESH:"Receptors, Nicotinic")) increases tloc(a(MESH:Sodium), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:28901280 + + complex(a(MESH:Acetylcholine), p(MESH:"Receptors, Nicotinic")) increases tloc(a(CHEBI:"calcium cation"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:28901280 + + complex(a(MESH:Acetylcholine), p(MESH:"Receptors, Nicotinic")) increases tloc(a(CHEBI:"potassium(1+)"), fromLoc(GO:intracellular), toLoc(GO:"extracellular region")) + + + + + + + pubmed:28901280 + + composite(a(MESH:Nicotine), p(MESH:"Receptors, Nicotinic")) increases complex(a(MESH:Nicotine), p(MESH:"Receptors, Nicotinic")) + + + + + + + + + + + pubmed:28901280 + + a(MESH:Nicotine) increases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) + + + + + + + pubmed:28901280 + + a(MESH:Nicotine) increases complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2)) + + + + + + + pubmed:28901280 + + a(MESH:Nicotine) decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) + + + + + + + pubmed:28901280 + + a(MESH:Nicotine) decreases bp(GO:"neuron death") + + + + + + + pubmed:28901280 + + a(MESH:Nicotine) increases p(MESH:"Receptors, Nicotinic") + + + + + + + pubmed:28901280 + + a(MESH:Nicotine) increases bp(GO:"nodal receptor complex assembly") + + + + + + + pubmed:28901280 + + a(MESH:Nicotine) increases act(p(MESH:"Proteasome Endopeptidase Complex")) + + + + + + + pubmed:28901280 + + a(MESH:Nicotine) increases a(MESH:Glutamates) + + + + + + + pubmed:28901280 + + a(MESH:Nicotine) increases a(MESH:Glutamates) + + + + + + + pubmed:28901280 + + a(MESH:Nicotine) increases p(MESH:"Receptors, GABA") + + + + + + + pubmed:28901280 + + a(MESH:Nicotine) decreases p(MESH:"Receptors, GABA") + + + + + + + pubmed:28901280 + + a(MESH:Nicotine) increases bp(GO:"action potential initiation") + + + + + + + pubmed:28901280 + + a(MESH:Nicotine) increases a(MESH:Dopamine, loc(MESH:"Nucleus Accumbens")) + + + + + + + pubmed:28901280 + + a(MESH:Nicotine) increases a(MESH:Dopamine, loc(MESH:"Nucleus Accumbens")) + + + + + + + pubmed:28901280 + + a(MESH:Nicotine) increases act(p(HGNC:CHRNA7)) + + + + + + + pubmed:28901280 + + a(MESH:Nicotine) decreases act(p(HGNC:CHRNA7)) + + + + + + + pubmed:28901280 + + a(MESH:Nicotine) increases act(p(MESH:"Receptors, N-Methyl-D-Aspartate")) + + + + + + + pubmed:28901280 + + a(MESH:Nicotine) increases bp(MESH:"Long-Term Potentiation") + + + + + + + pubmed:28901280 + + act(a(MESH:Nicotine)) association g(DBSNP:rs16969968) + + + + + + + pubmed:28901280 + + a(MESH:Nicotine) increases p(MGI:Chrna5) + + + + + + + pubmed:28901280 + + a(MESH:Nicotine) increases p(MGI:Chrna2) + + + + + + + pubmed:28901280 + + a(MESH:Nicotine) increases path(MESH:Neoplasms) + + + + + + + pubmed:28901280 + + a(MESH:Nicotine) causesNoChange act(complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9))) + + + + + + + pubmed:28901280 + + a(MESH:Nicotine) causesNoChange act(p(HGNC:CHRNA9)) + + + + + + + pubmed:28901280 + + complex(a(MESH:Nicotine), p(MESH:"Receptors, Nicotinic"), loc(MESH:Brain)) decreases path(MESH:Anxiety) + + + + + + + pubmed:28901280 + + complex(a(MESH:"Receptors, Muscarinic"), a(MESH:Acetylcholine)) increases act(a(MESH:"Central Nervous System")) + + + + + + + + + pubmed:28901280 + + bp(GO:"cell-cell signaling") association a(MESH:Acetylcholine) + + + + + + + pubmed:19933700 + + bp(GO:"cell-cell signaling") association p(HGNC:PPP2R1A) + + + + + + + pubmed:26751493 + + bp(GO:"cell-cell signaling") association complex(p(CONSO:"projection domain"), p(HGNC:LCK)) + + + + + + + pubmed:26751493 + + bp(GO:"cell-cell signaling") association complex(p(CONSO:"projection domain"), p(HGNC:FGR)) + + + + + + + pubmed:26751493 + + bp(GO:"cell-cell signaling") association complex(p(CONSO:"projection domain"), p(HGNC:SRC)) + + + + + + + pubmed:26751493 + + bp(GO:"cell-cell signaling") association complex(p(CONSO:"projection domain"), p(HGNC:GRB2)) + + + + + + + pubmed:26751493 + + bp(GO:"cell-cell signaling") association complex(p(CONSO:"projection domain"), p(FPLX:PLC)) + + + + + + + pubmed:26751493 + + bp(GO:"cell-cell signaling") association complex(a(CHEBI:phosphatidylinositol), p(CONSO:"projection domain")) + + + + + + + pubmed:26751493 + + bp(GO:"cell-cell signaling") association complex(a(CHEBI:"phosphatidylinositol bisphosphate"), p(CONSO:"projection domain")) + + + + + + + pubmed:26751493 + + bp(GO:"cell-cell signaling") association complex(p(CONSO:"projection domain"), p(HGNC:PIN1)) + + + + + + + pubmed:28901280 + + bp(GO:"cell proliferation") association a(MESH:Acetylcholine) + + + + + + + pubmed:28901280 + + bp(GO:"cell proliferation") association p(MESH:"Receptors, Nicotinic") + + + + + + + pubmed:28901280 + + bp(GO:"secretion by cell") association a(MESH:Acetylcholine) + + + + + + + pubmed:28901280 + + bp(MESH:"Autocrine Communication") association a(MESH:Acetylcholine) + + + + + + + pubmed:28901280 + + bp(MESH:"Paracrine Communication") association a(MESH:Acetylcholine) + + + + + + + pubmed:28901280 + + a(MESH:Erythrocytes) increases a(MESH:Acetylcholine) + + + + + + + pubmed:28901280 + + a(MESH:Erythrocytes) increases a(MESH:"Choline O-Acetyltransferase") + + + + + + + pubmed:29626319 + + a(MESH:Erythrocytes) increases deg(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:29626319 + + a(MESH:Erythrocytes) increases deg(a(CHEBI:amyloid-beta)) + + + + + + + + + pubmed:28901280 + + a(MESH:"Epithelial Cells") increases a(MESH:Acetylcholine) + + + + + + + pubmed:28901280 + + a(MESH:"Epithelial Cells") increases a(MESH:"Choline O-Acetyltransferase") + + + + + + + pubmed:28901280 + + a(MESH:Placenta) increases a(MESH:Acetylcholine) + + + + + + + pubmed:28901280 + + a(MESH:Placenta) increases a(MESH:"Choline O-Acetyltransferase") + + + + + + + pubmed:28901280 + + path(MESH:Learning) association p(MESH:"Receptors, Nicotinic") + + + + + + + pubmed:28901280 + + path(MESH:"Motor Activity") association p(MESH:"Receptors, Nicotinic") + + + + + + + pubmed:28391535 + + path(MESH:"Motor Activity") negativeCorrelation a(CHEBI:nicotine) + + + + + + + pubmed:28901280 + + bp(MESH:Analgesia) association p(MESH:"Receptors, Nicotinic") + + + + + + + pubmed:28901280 + + composite(p(HGNC:CHRNA7), p(HGNC:CHRNB2)) increases complex(p(HGNC:CHRNA7), p(HGNC:CHRNB2)) + + + + + + + pubmed:28901280 + + composite(p(HGNC:CHRNA7), p(HGNC:CHRNB3)) increases complex(p(HGNC:CHRNA7), p(HGNC:CHRNB3)) + + + + + + + pubmed:28901280 + + composite(p(HGNC:CHRNA7), p(HGNC:CHRNB4)) increases complex(p(HGNC:CHRNA7), p(HGNC:CHRNB4)) + + + + + + + pubmed:28901280 + + composite(p(HGNC:CHRNA5), p(HGNC:CHRNA7)) increases complex(p(HGNC:CHRNA5), p(HGNC:CHRNA7)) + + + + + + + pubmed:28901280 + + r(HGNC:CHRFAM7A) association a(MESH:Lymphocytes) + + + + + + + pubmed:28901280 + + a(MESH:Carbachol) increases p(MESH:"Receptors, Nicotinic") + + + + + + + pubmed:28901280 + + a(MESH:Varenicline) increases p(MESH:"Receptors, Nicotinic") + + + + + + + pubmed:28901280 + + a(MESH:Mecamylamine) increases p(MESH:"Receptors, Nicotinic") + + + + + + + pubmed:28901280 + + a(MESH:Glutamates) increases bp(MESH:"Long-Term Potentiation") + + + + + + + pubmed:28901280 + + a(MESH:Glutamates) increases bp(GO:"action potential initiation") + + + + + + + pubmed:28901280 + + bp(UBERON:0002138) positiveCorrelation p(MESH:"Receptors, Nicotinic") + + + + + + + pubmed:28901280 + + bp(UBERON:0002138) positiveCorrelation p(HGNC:CHRNA3) + + + + + + + pubmed:28901280 + + bp(UBERON:0002138) positiveCorrelation p(HGNC:CHRNB4) + + + + + + + pubmed:28901280 + + bp(UBERON:0002138) positiveCorrelation p(HGNC:CHRNA5) + + + + + + + pubmed:28901280 + + p(MGI:Chrna5) regulates act(a(MESH:Nicotine)) + + + + + + + pubmed:28901280 + + p(MGI:Chrnb4) decreases act(a(MESH:Nicotine)) + + + + + + + pubmed:28901280 + + p(INTERPRO:"Ly6/PLAUR domain-containing protein 6-like") regulates p(MESH:"Receptors, Nicotinic") + + + + + + + pubmed:28901280 + + composite(p(HGNC:CHRNA4), p(HGNC:CHRNA5), p(HGNC:CHRNB2)) increases complex(p(HGNC:CHRNA4), p(HGNC:CHRNA5), p(HGNC:CHRNB2)) + + + + + + + pubmed:28901280 + + composite(p(HGNC:CHRNA3), p(HGNC:CHRNA5), p(HGNC:CHRNB4)) increases complex(p(HGNC:CHRNA3), p(HGNC:CHRNA5), p(HGNC:CHRNB4)) + + + + + + + pubmed:28901280 + + g(DBSNP:rs1051730) association path(MESH:"Lung Neoplasms") + + + + + + + pubmed:28901280 + + g(DBSNP:rs1051730) association path(MESH:"Tobacco Use Disorder") + + + + + + + pubmed:28901280 + + bp(GO:"JAK-STAT cascade") increases a(CHEBI:"calcium cation", loc(GO:intracellular)) + + + + + + + pubmed:28901280 + + a(MESH:Epithelium) regulates a(MESH:Acetylcholine) + + + + + + + pubmed:28901280 + + act(a(MESH:Epithelium)) association p(MGI:Chrna7) + + + + + + + pubmed:28901280 + + a(MESH:Choline) increases act(p(HGNC:CHRNA9)) + + + + + + + pubmed:28901280 + + a(MESH:Phosphorylcholine) causesNoChange complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) + + + + + + + pubmed:28901280 + + a(MESH:Phosphorylcholine) causesNoChange p(HGNC:CHRNA9) + + + + + + + pubmed:28901280 + + a(MESH:"Ganglia, Spinal") increases complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) + + + + + + + pubmed:28901280 + + a(MESH:"Ganglia, Spinal") increases p(HGNC:CHRNA9) + + + + + + + pubmed:28901280 + + path(MESH:"Breast Neoplasms") increases p(HGNC:CHRNA9) + + + + + + + pubmed:28901280 + + path(MESH:"Breast Neoplasms") increases p(HGNC:CHRNA9) + + + + + + + pubmed:28901280 + + path(MESH:"Breast Neoplasms") increases complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) + + + + + + + pubmed:28901280 + + path(MESH:"Breast Neoplasms") increases p(HGNC:CHRNA5) + + + + + + + pubmed:28901280 + + path(MESH:"Breast Neoplasms") increases p(HGNC:CHRNA10) + + + + + + + pubmed:23516100 + + p(MESH:Proteins, frag("?")) increases p(MESH:Proteins) + + + + + + + pubmed:23516100 + + p(MESH:Proteins, frag("?")) negativeCorrelation act(complex(GO:organelle)) + + + + + + + pubmed:23516100 + + p(MESH:Proteins, frag("?")) association path(MESH:"Oxidative Stress") + + + + + + + pubmed:23516100 + + p(MESH:Proteins, frag("?")) association bp(GO:"cell death") + + + + + + + pubmed:23516100 + + act(complex(GO:organelle)) negativeCorrelation p(MESH:Proteins, frag("?")) + + + + + + + pubmed:23516100 + + p(HGNC:MAPT, frag("?")) positiveCorrelation path(DOID:"neurodegenerative disease") + + + + + + + pubmed:23516100 + + p(HGNC:MAPT, frag("?")) positiveCorrelation path(DOID:tauopathy) + + + + + + + pubmed:23516100 + + p(HGNC:MAPT, frag("?")) increases path(MESH:Virulence) + + + + + + + pubmed:23516100 + + p(HGNC:MAPT, frag("?")) positiveCorrelation path(DOID:"Alzheimer's disease") + + + + + + + pubmed:23516100 + + p(HGNC:MAPT, frag("?")) increases p(GO:"neurofibrillary tangle") + + + + + + + pubmed:23516100 + + p(HGNC:MAPT, frag("?")) decreases act(p(MESH:Caspases)) + + + + + + + pubmed:23516100 + + p(HGNC:MAPT, frag("?")) increases complex(MESH:"Neurofibrillary Tangles") + + + + + + + pubmed:23516100 + + p(HGNC:MAPT, frag("?")) increases path(MESH:"Plaque, Amyloid") + + + + + + + pubmed:23516100 + + p(HGNC:MAPT, frag("?")) increases p(CONSO:"Tau aggregates") + + + + + + + pubmed:29758300 + + p(HGNC:MAPT, frag("?")) increases path(MESH:"Alzheimer Disease") + + + + + + + pubmed:29758300 + + p(HGNC:MAPT, frag("?")) association complex(GO:"proteasome complex") + + + + + + + pubmed:29758300 + + p(HGNC:MAPT, frag("?")) association bp(GO:autophagy) + + + + + + + pubmed:30116051 + + p(HGNC:MAPT, frag("?")) decreases bp(GO:"chaperone-mediated autophagy") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, frag("?")) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, frag("?")) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, frag("?")) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, frag("?")) increases path(CONSO:Neurodegeneration) + + + + + + + pubmed:29626319 + + p(HGNC:MAPT, frag("?")) increases path(CONSO:neurotoxicity) + + + + + + + + + pubmed:23516100 + + a(CONSO:MN423) increases complex(a(CONSO:MN423), p(HGNC:MAPT, frag("1_391"))) + + + + + + + pubmed:4255369 + + a(CONSO:MN423) increases a(CONSO:"Tau oligomers") + + + + + + + + + pubmed:23516100 + + p(HGNC:MAPT, frag("1_391")) increases p(CONSO:"Tau fibrils") + + + + + + + pubmed:23516100 + + p(HGNC:MAPT, frag("1_391")) increases p(CONSO:"Tau aggregates") + + + + + + + pubmed:23516100 + + p(HGNC:MAPT, frag("1_421")) positiveCorrelation path(DOID:"neurodegenerative disease") + + + + + + + pubmed:23516100 + + p(HGNC:MAPT, frag("1_421")) negativeCorrelation bp(GO:cognition) + + + + + + + + + + + + + pubmed:28420982 + + p(HGNC:MAPT, frag("1_421")) decreases bp(GO:"mitochondrion organization") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, frag("1_421")) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, frag("1_421")) increases a(GO:"neurofibrillary tangle") + + + + + + + pubmed:23516100 + + p(HGNC:MAPT, frag("?"), pmod(go:0006468 ! "protein phosphorylation")) decreases complex(a(MESH:Microtubules), p(HGNC:MAPT)) + + + + + + + pubmed:23516100 + + p(HGNC:MAPT, frag("?"), pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation bp(GO:"anterograde axonal transport") + + + + + + + pubmed:23516100 + + p(HGNC:MAPT, frag("?"), pmod(go:0006468 ! "protein phosphorylation")) increases bp(GO:"cell death") + + + + + + + pubmed:23516100 + + p(HGNC:ATXN3, frag("1_?")) increases path(MESH:Virulence) + + + + + + + pubmed:23516100 + + p(HGNC:ATXN3, frag("1_?")) positiveCorrelation bp(GO:"neuron death") + + + + + + + + + + + + + + + + + + + + + + + pubmed:14556719 + + p(HGNC:ATXN3) increases complex(p(HGNC:ATXN3), p(HGNC:RAD23A)) + + + + + + + + + + + pubmed:23516100 + + p(HGNC:APP, frag("1_?")) decreases act(a(CHEBI:"cytochrome c")) + + + + + + + pubmed:23516100 + + p(HGNC:APP, frag("1_?")) increases a(CHEBI:"hydrogen peroxide") + + + + + + + pubmed:23516100 + + p(HGNC:APP, frag("1_?")) positiveCorrelation path(CONSO:"mitochondrial dysfunction") + + + + + + + pubmed:23516100 + + p(HGNC:APP, frag("1_?")) increases path(MESH:"Neurotoxicity Syndromes") + + + + + + + pubmed:23516100 + + p(HGNC:APP, frag("1_?")) decreases p(HGNC:APP, frag("?_*")) + + + + + + + pubmed:23516100 + + p(HGNC:APP, frag("1_?")) decreases act(p(MESH:"Molecular Motor Proteins")) + + + + + + + pubmed:23516100 + + p(HGNC:APP, frag("1_?")) decreases act(p(MESH:"Transcription Factors")) + + + + + + + + + pubmed:23516100 + + p(HGNC:SNCA, frag("1_119")) decreases a(CHEBI:dopamine) + + + + + + + pubmed:23516100 + + p(HGNC:SNCA, frag("1_119")) causesNoChange a(MESH:"Dopaminergic Neurons") + + + + + + + pubmed:23516100 + + p(HGNC:SNCA, frag("1_120")) decreases a(CHEBI:dopamine) + + + + + + + pubmed:23516100 + + p(HGNC:SNCA, frag("1_120")) increases path(MESH:"Oxidative Stress") + + + + + + + pubmed:23516100 + + p(HGNC:SNCA, frag("1_120")) increases p(CONSO:"alpha-synuclein aggregates") + + + + + + + pubmed:23516100 + + p(HGNC:SNCA, frag("1_?")) increases p(CONSO:"alpha-synuclein fibrils") + + + + + + + pubmed:23516100 + + p(HGNC:SNCA, frag("1_?")) increases p(CONSO:"alpha-synuclein aggregates") + + + + + + + pubmed:23516100 + + p(HGNC:SNCA, frag("1_?")) increases p(CONSO:"alpha-synuclein aggregates") + + + + + + + + + pubmed:12714745 + + p(CONSO:"alpha-synuclein fibrils") positiveCorrelation g(DBSNP:rs104893877) + + + + + + + pubmed:23516100 + + p(HGNC:HTT, frag("?"), loc(GO:nucleus)) increases bp(GO:"cell death") + + + + + + + pubmed:23516100 + + p(HGNC:HTT, frag("?")) increases bp(GO:"cell death") + + + + + + + pubmed:23516100 + + p(HGNC:HTT, frag("?")) increases tloc(p(HGNC:HTT, frag("?")), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) + + + + + + + pubmed:23516100 + + p(HGNC:HTT, frag("?")) positiveCorrelation path(DOID:"Huntington's disease") + + + + + + + pubmed:23516100 + + p(HGNC:HTT, frag("?")) increases path(MESH:"Neurotoxicity Syndromes") + + + + + + + pubmed:23516100 + + path(DOID:"Lewy body dementia") increases p(HGNC:SNCA, frag("10_122")) + + + + + + + + + pubmed:23516100 + + act(p(HGNC:CASP7)) increases complex(p(HGNC:CASP7), p(HGNC:MAPT, frag("1_421"))) + + + + + + + pubmed:23516100 + + p(HGNC:CASP7) increases p(HGNC:MAPT, frag("?")) + + + + + + + pubmed:23516100 + + p(HGNC:CASP7) increases p(HGNC:MAPT, frag("421_*"), var("?")) + + + + + + + pubmed:23516100 + + act(p(HGNC:CASP7)) increases p(HGNC:ATXN7, frag("?")) + + + + + + + + + pubmed:23516100 + + tloc(p(HGNC:CASP7), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) increases act(p(HGNC:CASP7, loc(GO:nucleus))) + + + + + + + pubmed:23516100 + + act(p(HGNC:CASP7)) increases p(HGNC:TARDBP, frag("?")) + + + + + + + + + pubmed:23516100 + + act(p(HGNC:CASP6)) increases p(HGNC:HTT, frag("1_586")) + + + + + + + pubmed:23516100 + + p(HGNC:CASP6) increases p(HGNC:HTT, frag("1_586")) + + + + + + + pubmed:23516100 + + p(HGNC:CASP6) increases p(HGNC:MAPT, frag("1_13")) + + + + + + + pubmed:23516100 + + p(HGNC:CASP6) increases p(HGNC:MAPT, frag("1_402")) + + + + + + + pubmed:23516100 + + p(HGNC:CASP6) increases p(HGNC:MAPT, frag("?")) + + + + + + + + + pubmed:24027553 + + act(p(HGNC:CASP6)) increases p(HGNC:MAPT, frag("?_*")) + + + + + + + pubmed:24027553 + + act(p(HGNC:CASP6)) increases p(HGNC:MAPT, frag("?_*")) + + + + + + + pubmed:24027553 + + act(p(HGNC:CASP6)) increases p(HGNC:MAPT, frag("1_?")) + + + + + + + pubmed:24027553 + + act(p(HGNC:CASP6)) increases p(HGNC:MAPT, frag("1_?")) + + + + + + + pubmed:24027553 + + act(p(HGNC:CASP6)) increases bp(GO:"apoptotic process") + + + + + + + pubmed:24027553 + + act(p(HGNC:CASP6)) increases p(HGNC:MAPT, var("p.Asp421*")) + + + + + + + pubmed:24027553 + + act(p(HGNC:CASP6)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:23516100 + + p(HGNC:HTT, frag("1_586")) increases tloc(p(HGNC:HTT, frag("1_586")), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) + + + + + + + pubmed:23516100 + + tloc(p(HGNC:HTT, frag("1_586")), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) increases a(MESH:"Toxic Actions") + + + + + + + pubmed:23516100 + + path(MESH:"TDP-43 Proteinopathies") increases tloc(p(HGNC:TARDBP), fromLoc(GO:nucleus), toLoc(GO:cytoplasm)) + + + + + + + pubmed:30837838 + + path(MESH:"TDP-43 Proteinopathies") increases tloc(p(HGNC:TARDBP), fromLoc(GO:nucleus), toLoc(GO:cytoplasm)) + + + + + + + pubmed:18305152 + + path(MESH:"TDP-43 Proteinopathies") association p(CONSO:"TDP-43 aggregates", loc(GO:cytoplasm)) + + + + + + + pubmed:18305152 + + path(MESH:"TDP-43 Proteinopathies") isA path(DOID:"frontotemporal dementia") + + + + + + + pubmed:28669544 + + path(MESH:"TDP-43 Proteinopathies") increases path(EFO:"neurodegenerative disease") + + + + + + + pubmed:28669544 + + path(MESH:"TDP-43 Proteinopathies") increases deg(p(HGNC:APP)) + + + + + + + pubmed:28669544 + + path(MESH:"TDP-43 Proteinopathies") decreases path(DOID:"Alzheimer's disease") + + + + + + + pubmed:28669544 + + path(MESH:"TDP-43 Proteinopathies") directlyIncreases p(HGNC:CD68) + + + + + + + pubmed:30837838 + + path(MESH:"TDP-43 Proteinopathies") decreases p(HGNC:TARDBP, pmod(CONSO:hyperphosphorylation), loc(GO:"inclusion body")) + + + + + + + pubmed:30837838 + + path(MESH:"TDP-43 Proteinopathies") decreases p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination"), loc(GO:"inclusion body")) + + + + + + + pubmed:30837838 + + path(MESH:"TDP-43 Proteinopathies") decreases complex(CONSO:"TDP-43 aggregates") + + + + + + + pubmed:30837838 + + path(MESH:"TDP-43 Proteinopathies") decreases p(HGNC:TARDBP, frag("274_414")) + + + + + + + pubmed:23516100 + + p(HGNC:TARDBP, frag("?_*")) increases tloc(p(HGNC:TARDBP), fromLoc(GO:nucleus), toLoc(GO:cytoplasm)) + + + + + + + pubmed:23516100 + + p(HGNC:TARDBP, frag("?_*")) increases p(CONSO:"TDP-43 aggregates") + + + + + + + pubmed:18305152 + + p(CONSO:"TDP-43 aggregates", loc(GO:cytoplasm)) association path(DOID:"frontotemporal dementia") + + + + + + + pubmed:18305152 + + p(CONSO:"TDP-43 aggregates", loc(GO:cytoplasm)) association path(MESH:"TDP-43 Proteinopathies") + + + + + + + pubmed:23384725 + + p(CONSO:"TDP-43 aggregates") association p(HGNC:TARDBP, frag("101_191"), pmod(GO:"protein oxidation", Cys, 173)) + + + + + + + pubmed:23384725 + + p(CONSO:"TDP-43 aggregates") association p(HGNC:TARDBP, frag("101_191"), pmod(GO:"protein oxidation", Cys, 175)) + + + + + + + pubmed:30837838 + + p(CONSO:"TDP-43 aggregates", loc(GO:"inclusion body")) decreases act(p(HGNC:TARDBP)) + + + + + + + pubmed:30837838 + + p(CONSO:"TDP-43 aggregates") increases p(HGNC:TARDBP, loc(GO:"inclusion body")) + + + + + + + pubmed:30837838 + + p(CONSO:"TDP-43 aggregates", loc(GO:"inclusion body")) increases a(MESH:"Toxic Actions") + + + + + + + pubmed:30837838 + + act(p(CONSO:"TDP-43 aggregates"), ma(GO:"protease binding")) increases p(HGNC:TARDBP, frag("104_*")) + + + + + + + + + + + pubmed:30837838 + + p(CONSO:"TDP-43 aggregates") decreases p(CONSO:"amyloid-beta aggregates") + + + + + + + + + pubmed:23516100 + + p(MESH:"Peptide Hydrolases") increases p(HGNC:MAPT, frag("128_*")) + + + + + + + pubmed:23516100 + + p(MESH:"Peptide Hydrolases") increases p(HGNC:TARDBP, frag("208_*")) + + + + + + + pubmed:23516100 + + p(MESH:"Peptide Hydrolases") increases p(HGNC:TARDBP, frag("1_219")) + + + + + + + pubmed:23516100 + + p(MESH:"Peptide Hydrolases") increases p(HGNC:TARDBP, frag("1_247")) + + + + + + + pubmed:23516100 + + p(HGNC:MAPT, pmod(CONSO:deamidation)) increases p(HGNC:MAPT, frag("1_255")) + + + + + + + pubmed:23516100 + + p(HGNC:MAPT, pmod(CONSO:deamidation)) increases p(HGNC:MAPT, frag("266_*")) + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, pmod(CONSO:deamidation)) association a(CONSO:"paired helical filaments") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, pmod(CONSO:deamidation)) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:30106381 + + bp(GO:"nervous system development") association p(HGNC:ADNP) + + + + + + + pubmed:23516100 + + bp(CONSO:"Glutamate excitotoxicity") negativeCorrelation bp(GO:"calcium ion homeostasis") + + + + + + + pubmed:23516100 + + bp(CONSO:"Glutamate excitotoxicity") decreases act(p(HGNCGENEFAMILY:Calpains)) + + + + + + + + + pubmed:23516100 + + act(p(HGNC:CAPN1)) increases complex(p(GO:"neurofibrillary tangle"), p(HGNC:CAPN1)) + + + + + + + + + pubmed:23516100 + + act(p(HGNC:CAPN1)) increases complex(p(HGNC:CAPN1), p(MESH:"Neuropil Threads")) + + + + + + + pubmed:23516100 + + p(HGNC:CAPN1) increases p(HGNC:SNCA, frag("?"), var("p.Ala53Thr")) + + + + + + + pubmed:23516100 + + p(HGNC:CAPN1) increases p(HGNC:SNCA, frag("?"), var("p.Ala30Pro")) + + + + + + + pubmed:23516100 + + p(HGNC:CAPN1) increases p(CONSO:"alpha-synuclein aggregates", frag("?")) + + + + + + + pubmed:30116051 + + p(HGNC:CAPN1) decreases bp(GO:autophagy) + + + + + + + pubmed:30116051 + + p(HGNC:CAPN1) decreases deg(p(HGNC:HTT, var("?"))) + + + + + + + + + pubmed:30837838 + + p(HGNC:CAPN1) increases p(HGNC:TARDBP, frag("?"), var("p.Ala315Thr")) + + + + + + + pubmed:30837838 + + p(HGNC:CAPN1) increases p(HGNC:TARDBP, frag("?"), var("p.Met337Val")) + + + + + + + + + + + + + pubmed:23516100 + + act(p(HGNC:CAPN2)) increases complex(p(GO:"neurofibrillary tangle"), p(HGNC:CAPN2)) + + + + + + + + + pubmed:23516100 + + act(p(HGNC:CAPN2)) increases complex(p(HGNC:CAPN2), p(MESH:"Neuropil Threads")) + + + + + + + pubmed:30116051 + + p(HGNC:CAPN2) decreases bp(GO:autophagy) + + + + + + + pubmed:30116051 + + p(HGNC:CAPN2) decreases deg(p(HGNC:HTT, var("?"))) + + + + + + + + + pubmed:24027553 + + p(HGNC:CAPN2) association path(MESH:"Neurofibrillary Tangles") + + + + + + + pubmed:23516100 + + p(HGNC:MAPT, frag("1_?")) decreases complex(a(MESH:Microtubules), p(HGNC:MAPT)) + + + + + + + pubmed:24027553 + + p(HGNC:MAPT, frag("1_?")) association path(MESH:"Neurofibrillary Tangles") + + + + + + + + + pubmed:23516100 + + a(CONSO:Alz50) increases composite(a(CONSO:Alz50), p(HGNC:MAPT, frag("83_120"))) + + + + + + + + + pubmed:23516100 + + p(MESH:"Serine Proteases") increases a(CHEBI:"amyloid-beta polypeptide 40") + + + + + + + pubmed:23516100 + + p(HGNC:SNCA, frag("?")) increases p(CONSO:"alpha-synuclein aggregates") + + + + + + + pubmed:30985105 + + p(HGNC:SNCA, frag("?")) increases a(CONSO:"alpha-synuclein aggregates") + + + + + + + pubmed:23516100 + + p(HGNC:HTT, frag("?_*")) increases bp(GO:"neuron death") + + + + + + + pubmed:23516100 + + path(DOID:"Machado-Joseph disease") increases p(HGNC:ATXN3, frag("?"), loc(GO:"nuclear inclusion body")) + + + + + + + pubmed:23516100 + + path(DOID:"Machado-Joseph disease") association p(HGNC:ATXN3, frag("190_*")) + + + + + + + pubmed:14556719 + + p(HGNC:ATXN3, frag("?")) decreases act(complex(GO:"proteasome complex")) + + + + + + + pubmed:14556719 + + p(HGNC:ATXN3, frag("?")) increases act(p(HGNC:CASP12)) + + + + + + + + + pubmed:23516100 + + p(HGNC:ATXN3, frag("1_260")) increases p(CONSO:"protein aggregates") + + + + + + + pubmed:23516100 + + p(HGNC:ATXN3, frag("214_*")) increases path(DOID:"neurodegenerative disease") + + + + + + + pubmed:23516100 + + p(HGNC:ATXN3, frag("190_*")) association path(DOID:"Machado-Joseph disease") + + + + + + + pubmed:24027553 + + p(HGNC:MAPT, frag("?_*")) association path(MESH:"Neurofibrillary Tangles") + + + + + + + pubmed:18305152 + + act(p(MESH:"Transcription Factors")) increases bp(GO:"cell division") + + + + + + + pubmed:18305152 + + act(p(MESH:"Transcription Factors")) increases bp(GO:"cell cycle G1/S phase transition") + + + + + + + pubmed:23516100 + + p(HGNC:ATXN7, frag("?")) positiveCorrelation path(DOID:"spinocerebellar ataxia type 7") + + + + + + + + + + + pubmed:23516100 + + complex(p(HGNC:ATXN7), p(HGNC:CASP7)) increases tloc(p(HGNC:CASP7), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) + + + + + + + pubmed:23516100 + + path(DOID:"spinocerebellar ataxia type 7") positiveCorrelation p(HGNC:ATXN7, frag("?")) + + + + + + + pubmed:23516100 + + a(GO:lysosome) negativeCorrelation path(DOID:"Alzheimer's disease") + + + + + + + pubmed:23516100 + + a(GO:lysosome) decreases p(HGNC:CTSD) + + + + + + + pubmed:18930136 + + a(GO:lysosome) negativeCorrelation p(HGNC:CTSD) + + + + + + + pubmed:29758300 + + a(GO:lysosome) increases bp(GO:"lysosomal protein catabolic process") + + + + + + + pubmed:22908190 + + a(GO:lysosome) increases deg(p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination"))) + + + + + + + pubmed:22908190 + + a(GO:lysosome) increases deg(p(HGNC:MAPT)) + + + + + + + + + pubmed:22908190 + + a(GO:lysosome) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:22908190 + + act(a(GO:lysosome)) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:22908190 + + a(GO:lysosome) increases a(GO:organelle) + + + + + + + + + pubmed:18930136 + + act(a(GO:lysosome)) decreases path(CONSO:Neurodegeneration) + + + + + + + pubmed:18930136 + + act(a(GO:lysosome)) increases a(GO:autophagosome) + + + + + + + pubmed:18930136 + + act(a(GO:lysosome)) increases a(GO:lysosome) + + + + + + + pubmed:18930136 + + act(a(GO:lysosome)) negativeCorrelation path(MESH:"Neuronal Ceroid-Lipofuscinoses") + + + + + + + pubmed:29024336 + + a(GO:lysosome) increases deg(p(CONSO:CONSO00053)) + + + + + + + + + + + + + + + + + pubmed:29590627 + + a(GO:lysosome) association p(HGNC:MAPT, var("p.Pro301Ser")) + + + + + + + pubmed:29590627 + + a(GO:lysosome) increases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + + + + + + + pubmed:29590627 + + a(GO:lysosome) association a(CONSO:"Tau aggregates") + + + + + + + pubmed:29590627 + + a(GO:lysosome) increases tloc(a(CONSO:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + + + + + + + pubmed:23229893 + + a(GO:lysosome) association p(HGNC:SUMO1) + + + + + + + + + pubmed:26702100 + + a(GO:lysosome) association p(HGNC:LAMP1) + + + + + + + pubmed:26702100 + + a(GO:lysosome) association p(HGNC:LAMP1) + + + + + + + pubmed:26702100 + + a(GO:lysosome) association p(HGNC:CD63) + + + + + + + + + pubmed:26702100 + + a(GO:lysosome) association p(HGNCGENEFAMILY:Cathepsins) + + + + + + + pubmed:26702100 + + a(GO:lysosome) association a(MESH:"Vacuolar Proton-Translocating ATPases") + + + + + + + pubmed:24561250 + + a(GO:lysosome) decreases act(complex(GO:"NLRP3 inflammasome complex")) + + + + + + + pubmed:23516100 + + p(HGNC:APP, var("p.Lys595Asn")) increases act(p(HGNC:CTSD)) + + + + + + + pubmed:23516100 + + p(HGNC:APP, var("p.Lys595Asn")) increases p(HGNC:APP, frag("?")) + + + + + + + pubmed:23516100 + + p(HGNC:APP, var("p.Met596Leu")) increases act(p(HGNC:CTSD)) + + + + + + + pubmed:23516100 + + p(HGNC:APP, var("p.Met596Leu")) increases p(HGNC:APP, frag("?")) + + + + + + + pubmed:23516100 + + a(PUBCHEM:10476) increases p(HGNC:MAPT, frag("?")) + + + + + + + pubmed:23516100 + + p(MESH:Proteins, pmod(CONSO:deamidation)) increases p(CONSO:"amyloid-beta fibrils") + + + + + + + pubmed:23516100 + + p(HGNC:TARDBP, pmod(CONSO:deamidation)) negativeCorrelation act(p(HGNC:TARDBP)) + + + + + + + pubmed:4255369 + + p(CONSO:DC8E8) decreases p(HGNC:MAPT, frag("?"), pmod(CONSO:"Tau oligomers")) + + + + + + + pubmed:4255369 + + p(CONSO:DC8E8) decreases a(CONSO:"Tau oligomers") + + + + + + + pubmed:4255369 + + p(CONSO:DC8E8) directlyDecreases a(CONSO:"Tau oligomers") + + + + + + + pubmed:4255369 + + p(CONSO:DC8E8) decreases complex(a(HGNC:MAPT), a(HGNC:MAPT)) + + + + + + + pubmed:4255369 + + p(CONSO:DC8E8) decreases complex(a(HGNC:MAPT), a(HGNC:MAPT), a(HGNC:MAPT)) + + + + + + + pubmed:4255369 + + p(CONSO:DC8E8) decreases p(CONSO:"4R tau", pmod(CONSO:"Tau oligomers"), var("p.151_391del")) + + + + + + + pubmed:4255369 + + p(CONSO:DC8E8) decreases a(CONSO:"Tau fibrils") + + + + + + + pubmed:4255369 + + p(CONSO:DC8E8) causesNoChange p(HGNC:MAPT) + + + + + + + + + pubmed:4255369 + + p(CONSO:DC8E8) directlyIncreases complex(p(CONSO:"4R tau", var("p.151_391del")), p(CONSO:DC8E8)) + + + + + + + + + pubmed:4255369 + + p(CONSO:DC8E8) directlyIncreases complex(p(CONSO:"4R tau", var("p.297_391del")), p(CONSO:DC8E8)) + + + + + + + + + pubmed:4255369 + + p(CONSO:DC8E8) directlyIncreases complex(p(CONSO:"4R tau", var("p.1_357del")), p(CONSO:DC8E8)) + + + + + + + + + pubmed:4255369 + + p(CONSO:DC8E8) directlyIncreases complex(p(CONSO:"4R tau", var("p.221_441del")), p(CONSO:DC8E8)) + + + + + + + + + pubmed:4255369 + + p(CONSO:DC8E8) increases complex(p(CONSO:"Tau isoform F (441 aa)"), p(CONSO:DC8E8)) + + + + + + + + + pubmed:4255369 + + p(CONSO:DC8E8) increases complex(p(CONSO:"Tau isoform C (410 aa)"), p(CONSO:DC8E8)) + + + + + + + + + pubmed:4255369 + + p(CONSO:DC8E8) decreases complex(p(CONSO:"Tau isoform F (441 aa)", var("p.222_427del")), p(CONSO:DC8E8)) + + + + + + + + + pubmed:4255369 + + p(CONSO:DC8E8) decreases complex(p(CONSO:"Tau isoform F (441 aa)", var("p.257_400del")), p(CONSO:DC8E8)) + + + + + + + pubmed:4255369 + + a(CONSO:"Tau oligomers") increases a(CONSO:"Tau fibrils") + + + + + + + pubmed:4255369 + + a(CONSO:"Tau oligomers") positiveCorrelation bp(GO:aging) + + + + + + + pubmed:4255369 + + a(CONSO:"Tau oligomers") increases path(MESH:"Motor Disorders") + + + + + + + pubmed:27574109 + + a(CONSO:"Tau oligomers") association a(CONSO:pretangles) + + + + + + + pubmed:27574109 + + a(CONSO:"Tau oligomers") association a(CONSO:"Braak_Stage I") + + + + + + + pubmed:27574109 + + a(CONSO:"Tau oligomers") association a(CONSO:"Braak_Stage II") + + + + + + + pubmed:27574109 + + a(CONSO:"Tau oligomers") association a(MESH:"Neurofibrillary Tangles") + + + + + + + pubmed:27574109 + + a(CONSO:"Tau oligomers") association path(CONSO:"Corticobasal Degeneration") + + + + + + + pubmed:27574109 + + a(CONSO:"Tau oligomers") positiveCorrelation path(CONSO:"Corticobasal Degeneration") + + + + + + + pubmed:27574109 + + a(CONSO:"Tau oligomers") positiveCorrelation path(CONSO:"Corticobasal Degeneration") + + + + + + + pubmed:27574109 + + a(CONSO:"Tau oligomers") association a(GO:"Pick body") + + + + + + + pubmed:27574109 + + a(CONSO:"Tau oligomers") positiveCorrelation path(MESH:Tauopathies) + + + + + + + pubmed:29686391 + + a(CONSO:"Tau oligomers") positiveCorrelation path(MESH:Tauopathies) + + + + + + + pubmed:28420982 + + a(CONSO:"Tau oligomers") increases path(MESH:Tauopathies) + + + + + + + pubmed:28420982 + + a(CONSO:"Tau oligomers") increases path(MESH:Tauopathies) + + + + + + + pubmed:27574109 + + a(CONSO:"Tau oligomers") positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:27574109 + + a(CONSO:"Tau oligomers") positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:25887395 + + a(CONSO:"Tau oligomers") positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:28420982 + + a(CONSO:"Tau oligomers") positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:26631930 + + a(CONSO:"Tau oligomers") positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:27574109 + + a(CONSO:"Tau oligomers") positiveCorrelation path(MESH:"Pick Disease of the Brain") + + + + + + + pubmed:27574109 + + a(CONSO:"Tau oligomers") positiveCorrelation path(MESH:"Pick Disease of the Brain") + + + + + + + pubmed:28528849 + + a(CONSO:"Tau oligomers") decreases bp(GO:"long-term synaptic potentiation") + + + + + + + pubmed:28528849 + + a(CONSO:"Tau oligomers") decreases bp(GO:memory) + + + + + + + pubmed:28420982 + + a(CONSO:"Tau oligomers") decreases bp(GO:memory) + + + + + + + pubmed:29191965 + + a(CONSO:"Tau oligomers") decreases a(MESH:Neurons) + + + + + + + pubmed:29686391 + + a(CONSO:"Tau oligomers") positiveCorrelation path(CONSO:neurotoxicity) + + + + + + + pubmed:22817713 + + a(CONSO:"Tau oligomers") increases path(CONSO:neurotoxicity) + + + + + + + pubmed:22817713 + + a(CONSO:"Tau oligomers") increases path(CONSO:neurotoxicity) + + + + + + + pubmed:26671985 + + act(a(CONSO:"Tau oligomers")) increases path(CONSO:neurotoxicity) + + + + + + + pubmed:26671985 + + a(CONSO:"Tau oligomers") positiveCorrelation path(CONSO:neurotoxicity) + + + + + + + pubmed:29686391 + + tloc(a(CONSO:"Tau oligomers"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) positiveCorrelation a(CONSO:"Tau oligomers") + + + + + + + pubmed:29686391 + + a(CONSO:"Tau oligomers") positiveCorrelation tloc(a(CONSO:"Tau oligomers"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:30985105 + + a(CONSO:"Tau oligomers") increases a(GO:"neurofibrillary tangle") + + + + + + + pubmed:28420982 + + a(CONSO:"Tau oligomers") increases path(MESH:Disease) + + + + + + + pubmed:28420982 + + a(CONSO:"Tau oligomers") increases bp(HP:Neurodegeneration) + + + + + + + pubmed:28420982 + + a(CONSO:"Tau oligomers") increases bp(HP:Neurodegeneration) + + + + + + + pubmed:22817713 + + a(CONSO:"Tau oligomers") increases bp(HP:Neurodegeneration) + + + + + + + pubmed:28420982 + + a(CONSO:"Tau oligomers") increases path(MESH:"Brain Injuries, Traumatic") + + + + + + + pubmed:28420982 + + a(CONSO:"Tau oligomers") decreases a(GO:synapse) + + + + + + + pubmed:28420982 + + a(CONSO:"Tau oligomers") increases a(CONSO:"granular tau oligomers") + + + + + + + pubmed:28420982 + + a(CONSO:"Tau oligomers") positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") + + + + + + + pubmed:26631930 + + a(CONSO:"Tau oligomers") positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") + + + + + + + pubmed:28420982 + + a(CONSO:"Tau oligomers") decreases bp(GO:cognition) + + + + + + + pubmed:28420982 + + a(CONSO:"Tau oligomers") decreases bp(GO:"mitochondrion organization") + + + + + + + pubmed:28420982 + + a(CONSO:"Tau oligomers") decreases bp(GO:"maintenance of synapse structure") + + + + + + + pubmed:28420982 + + a(CONSO:"Tau oligomers") increases tloc(p(HGNC:MAPT), fromLoc(GO:"neuron part"), toLoc(GO:"neuron part")) + + + + + + + pubmed:28420982 + + a(CONSO:"Tau oligomers") increases a(CONSO:"Tau annular protofibrils") + + + + + + + pubmed:28420982 + + a(CONSO:"Tau oligomers") decreases bp(MESH:"Cell Survival") + + + + + + + pubmed:28420982 + + a(CONSO:"Tau oligomers") association p(HGNC:PRNP) + + + + + + + pubmed:28420982 + + a(CONSO:"Tau oligomers") decreases act(a(GO:microtubule)) + + + + + + + pubmed:28420982 + + a(CONSO:"Tau oligomers") decreases a(MESH:"Electron Transport Complex I") + + + + + + + pubmed:28420982 + + a(CONSO:"Tau oligomers") decreases act(a(MESH:"Electron Transport Complex I")) + + + + + + + pubmed:28420982 + + a(CONSO:"Tau oligomers") decreases bp(GO:"ATP synthesis coupled proton transport") + + + + + + + pubmed:28420982 + + a(CONSO:"Tau oligomers") increases act(p(HGNC:CASP9)) + + + + + + + pubmed:28420982 + + a(CONSO:"Tau oligomers") increases tloc(p(HGNC:CYCS), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:27373205 + + a(CONSO:"Tau oligomers") association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) + + + + + + + pubmed:22817713 + + a(CONSO:"Tau oligomers") association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) + + + + + + + pubmed:26631930 + + a(CONSO:"Tau oligomers") increases path(CONSO:Neurodegeneration) + + + + + + + pubmed:26631930 + + a(CONSO:"Tau oligomers") decreases a(MESH:"Dendritic Spines") + + + + + + + + + pubmed:22817713 + + a(CONSO:"Tau oligomers") increases a(CONSO:"Tau aggregates") + + + + + + + + + pubmed:26751493 + + a(CONSO:"Tau oligomers") increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:22817713 + + a(CONSO:"Tau oligomers") association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) + + + + + + + pubmed:22817713 + + a(CONSO:"Tau oligomers") association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) + + + + + + + pubmed:29238289 + + a(CONSO:"Tau oligomers") decreases path(MESH:Memory) + + + + + + + pubmed:29238289 + + a(CONSO:"Tau oligomers") decreases bp(MESH:"Long-Term Potentiation") + + + + + + + pubmed:26671985 + + act(a(CONSO:"Tau oligomers")) decreases act(complex(GO:axon)) + + + + + + + pubmed:26671985 + + a(CONSO:"Tau oligomers") biomarkerFor path(MESH:"Chronic Traumatic Encephalopathy") + + + + + + + pubmed:27716675 + + a(CONSO:"Tau oligomers") positiveCorrelation path(CONSO:neuroinflammation) + + + + + + + pubmed:27716675 + + a(CONSO:"Tau oligomers") increases path(CONSO:"Pathological Tau Spreading") + + + + + + + pubmed:27716675 + + a(CONSO:"Tau oligomers") increases path(HP:Neurodegeneration) + + + + + + + pubmed:4255369 + + a(CONSO:DC11) increases a(CONSO:"Tau oligomers") + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + pubmed:25478017 + + a(CONSO:AADvac1) directlyIncreases complex(a(CONSO:AADvac1), p(CONSO:"Tau isoform F (441 aa)", frag("?"))) + + + + + + + + + pubmed:25478017 + + a(CONSO:AADvac1) directlyIncreases complex(a(CONSO:AADvac1), p(CONSO:"4R tau", var("p.151_391del"))) + + + + + + + + + pubmed:25478017 + + a(CONSO:AADvac1) directlyIncreases complex(a(CONSO:AADvac1), p(CONSO:"Tau isoform F (441 aa)")) + + + + + + + + + pubmed:25478017 + + a(CONSO:AADvac1) directlyDecreases p(HGNC:MAPT, frag("?"), pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:25478017 + + a(CONSO:AADvac1) directlyDecreases p(CONSO:"Tau oligomers") + + + + + + + pubmed:25478017 + + a(CONSO:AADvac1) decreases p(CONSO:"Tau oligomers") + + + + + + + pubmed:25478017 + + a(CONSO:AADvac1) directlyDecreases p(HGNC:MAPT) + + + + + + + pubmed:25478017 + + a(CONSO:AADvac1) directlyDecreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 217)) + + + + + + + pubmed:25478017 + + a(CONSO:AADvac1) directlyDecreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) + + + + + + + pubmed:25478017 + + a(CONSO:AADvac1) directlyDecreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) + + + + + + + pubmed:25478017 + + a(CONSO:AADvac1) directlyDecreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) + + + + + + + pubmed:25478017 + + a(CONSO:AADvac1) directlyDecreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 181)) + + + + + + + pubmed:25478017 + + a(CONSO:AADvac1) decreases path(MESH:Tauopathies) + + + + + + + pubmed:25478017 + + a(CONSO:AADvac1) decreases complex(p(HGNC:MAPT), p(HGNC:MAPT)) + + + + + + + pubmed:25478017 + + a(CONSO:AADvac1) decreases complex(p(HGNC:MAPT), p(HGNC:MAPT), p(HGNC:MAPT)) + + + + + + + pubmed:25478017 + + a(CONSO:AADvac1) decreases a(CONSO:"paired helical filaments") + + + + + + + pubmed:25478017 + + a(CONSO:AADvac1) negativeCorrelation path(HP:"Sensorimotor neuropathy") + + + + + + + pubmed:25478017 + + a(CONSO:AADvac1) causesNoChange path(MESH:"Erythrocyte Count") + + + + + + + pubmed:25478017 + + a(CONSO:AADvac1) causesNoChange complex(GO:"hemoglobin complex") + + + + + + + pubmed:25478017 + + a(CONSO:AADvac1) causesNoChange path(MESH:"Erythrocyte Indices") + + + + + + + pubmed:25478017 + + a(CONSO:AADvac1) causesNoChange path(MESH:"Reticulocyte Count") + + + + + + + pubmed:25478017 + + a(CONSO:AADvac1) causesNoChange path(MESH:"Platelet Count") + + + + + + + pubmed:25478017 + + a(CONSO:AADvac1) causesNoChange path(MESH:"Leukocyte Count") + + + + + + + + + pubmed:25478017 + + p(CONSO:"Tau isoform F (441 aa)", frag("?")) increases p(MESH:"Immunoglobulin G") + + + + + + + pubmed:25478017 + + complex(a(CONSO:AADvac1), a(CONSO:DC8E8)) increases complex(GO:"immunoglobulin complex") + + + + + + + + + + + pubmed:25478017 + + complex(GO:"immunoglobulin complex") positiveCorrelation complex(complex(GO:"immunoglobulin complex"), p(CONSO:"4R tau", var("p.151_391del"))) + + + + + + + + + pubmed:30988501 + + complex(GO:"immunoglobulin complex") decreases path(DOID:"multiple sclerosis") + + + + + + + pubmed:25478017 + + complex(complex(GO:"immunoglobulin complex"), p(CONSO:"4R tau", var("p.151_391del"))) positiveCorrelation complex(GO:"immunoglobulin complex") + + + + + + + pubmed:25478017 + + bp(GO:"T-helper 2 cell activation") increases complex(a(MESH:"Immunoglobulin G"), p(CONSO:"4R tau", var("p.151_391del"))) + + + + + + + + + pubmed:17078951 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 217)) positiveCorrelation p(FPLX:PKA) + + + + + + + pubmed:22072628 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 217)) partOf p(CONSO:"proline-rich region 2", pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:24653673 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) decreases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:MAPT)) + + + + + + + pubmed:24653673 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:17403556 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:22253473 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:24653673 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) decreases act(complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A))) + + + + + + + pubmed:24653673 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) decreases act(complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A))) + + + + + + + pubmed:10391244 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) association p(HGNC:PIN1, frag("5_39")) + + + + + + + + + pubmed:10391244 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) negativeCorrelation act(p(HGNC:MAPT), ma(GO:"microtubule binding")) + + + + + + + pubmed:21367866 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) positiveCorrelation p(HGNC:CDC37) + + + + + + + pubmed:17078951 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) positiveCorrelation p(FPLX:PKA) + + + + + + + pubmed:23948915 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) negativeCorrelation bp(GO:"apoptotic process") + + + + + + + pubmed:22833681 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) equivalentTo p(CONSO:"Tau epitope, AT180") + + + + + + + + + pubmed:22926167 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:22926167 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) increases a(GO:"neurofibrillary tangle") + + + + + + + pubmed:22299660 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:29191965 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:23088643 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:28784767 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) partOf p(CONSO:"Tau epitope, AT8") + + + + + + + pubmed:23088643 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) partOf p(CONSO:"Tau epitope, AT8") + + + + + + + pubmed:25331948 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) partOf p(CONSO:"Tau epitope, AT8") + + + + + + + pubmed:22833681 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) partOf p(CONSO:"Tau epitope, AT8") + + + + + + + pubmed:22817713 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) association a(CONSO:"Tau aggregates") + + + + + + + pubmed:22817713 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) association a(CONSO:"Tau oligomers") + + + + + + + pubmed:22486774 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) partOf a(CONSO:"Tau oligomers") + + + + + + + pubmed:14612456 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) isA p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:20071522 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) isA p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:20071522 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) association complex(p(HGNC:FKBP5), p(HGNC:MAPT)) + + + + + + + pubmed:20071522 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) positiveCorrelation p(HGNC:FKBP5) + + + + + + + pubmed:21367866 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) positiveCorrelation p(HGNC:CDC37) + + + + + + + pubmed:17078951 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) positiveCorrelation p(FPLX:PKA) + + + + + + + pubmed:28784767 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) increases p(CONSO:"Tau aggregates") + + + + + + + pubmed:25331948 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) equivalentTo p(CONSO:"Tau epitope, CP13") + + + + + + + pubmed:19459590 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) decreases complex(a(MESH:Microtubules), p(HGNC:MAPT)) + + + + + + + pubmed:22833681 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) increases complex(p(HGNC:FYN), p(HGNC:MAPT)) + + + + + + + pubmed:22833681 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) positiveCorrelation p(HGNC:MAPT, pmod(CONSO:O-GlcNAcylation)) + + + + + + + pubmed:24406748 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Ser")) + + + + + + + pubmed:23294633 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) + + + + + + + pubmed:22002427 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) positiveCorrelation p(HGNC:MAPT, var("p.Glu391*")) + + + + + + + pubmed:22253473 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) partOf a(GO:"neurofibrillary tangle") + + + + + + + pubmed:21734277 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) positiveCorrelation p(CONSO:"phosphatase-activating domain") + + + + + + + pubmed:28784767 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) partOf p(CONSO:"Tau epitope, AT8") + + + + + + + pubmed:25331948 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) partOf p(CONSO:"Tau epitope, AT8") + + + + + + + pubmed:22833681 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) partOf p(CONSO:"Tau epitope, AT8") + + + + + + + pubmed:24760868 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) increases p(HGNC:MAPT, loc(MESH:"Dendritic Spines")) + + + + + + + pubmed:29191965 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:22817713 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) association a(CONSO:"Tau aggregates") + + + + + + + pubmed:22817713 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) association a(CONSO:"Tau oligomers") + + + + + + + pubmed:22486774 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) partOf a(CONSO:"Tau oligomers") + + + + + + + pubmed:14612456 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) isA p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:17078951 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) positiveCorrelation p(FPLX:PKA) + + + + + + + pubmed:28784767 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) increases p(CONSO:"Tau aggregates") + + + + + + + pubmed:19459590 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) decreases complex(a(MESH:Microtubules), p(HGNC:MAPT)) + + + + + + + pubmed:22833681 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) increases complex(p(HGNC:FYN), p(HGNC:MAPT)) + + + + + + + pubmed:22833681 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) positiveCorrelation p(HGNC:MAPT, pmod(CONSO:O-GlcNAcylation)) + + + + + + + pubmed:24406748 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Ser")) + + + + + + + pubmed:23294633 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) + + + + + + + pubmed:22253473 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) partOf a(GO:"neurofibrillary tangle") + + + + + + + pubmed:21734277 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) positiveCorrelation p(CONSO:"phosphatase-activating domain") + + + + + + + pubmed:28420982 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 181)) association a(MESH:Exosomes) + + + + + + + pubmed:28420982 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 181)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:28420982 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 181)) positiveCorrelation path(MESH:"Frontotemporal Dementia") + + + + + + + pubmed:17078951 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 181)) positiveCorrelation p(FPLX:PKA) + + + + + + + pubmed:11943212 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 181)) partOf p(CONSO:"Tau epitope, AT270") + + + + + + + pubmed:25478017 + + complex(p(HGNC:MAPT), p(HGNC:MAPT)) increases path(MESH:Tauopathies) + + + + + + + pubmed:25887395 + + complex(p(HGNC:MAPT), p(HGNC:MAPT)) causesNoChange tloc(a(CONSO:"Tau fibrils"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + + + + + + + pubmed:25887395 + + complex(p(HGNC:MAPT), p(HGNC:MAPT)) causesNoChange a(CONSO:"Tau aggregates") + + + + + + + pubmed:22817713 + + complex(p(HGNC:MAPT), p(HGNC:MAPT)) increases a(CONSO:"Tau oligomers") + + + + + + + pubmed:25478017 + + complex(p(HGNC:MAPT), p(HGNC:MAPT), p(HGNC:MAPT)) increases path(MESH:Tauopathies) + + + + + + + pubmed:25887395 + + complex(p(HGNC:MAPT), p(HGNC:MAPT), p(HGNC:MAPT)) increases tloc(a(CONSO:"Tau fibrils"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + + + + + + + pubmed:25887395 + + complex(p(HGNC:MAPT), p(HGNC:MAPT), p(HGNC:MAPT)) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:29988016 + + complex(p(HGNC:MAPT), p(HGNC:MAPT), p(HGNC:MAPT)) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:22299660 + + a(CONSO:"paired helical filaments") negativeCorrelation act(p(FPLX:PPP2)) + + + + + + + pubmed:14556719 + + a(CONSO:"paired helical filaments") decreases act(complex(GO:"proteasome complex")) + + + + + + + pubmed:22908190 + + a(CONSO:"paired helical filaments") negativeCorrelation act(complex(GO:"proteasome complex")) + + + + + + + pubmed:22908190 + + a(CONSO:"paired helical filaments") association a(GO:"neurofibrillary tangle") + + + + + + + pubmed:22908190 + + a(CONSO:"paired helical filaments") association a(CONSO:"dystrophic neurite") + + + + + + + pubmed:22908190 + + a(CONSO:"paired helical filaments") association p(HGNC:MAPT) + + + + + + + pubmed:22908190 + + a(CONSO:"paired helical filaments") association p(HGNC:MAPT) + + + + + + + pubmed:22908190 + + a(CONSO:"paired helical filaments") association a(MESH:Ubiquitin) + + + + + + + pubmed:22908190 + + a(CONSO:"paired helical filaments") association p(CONSO:"Tau isoform F (441 aa)", pmod(go:0016567 ! "protein ubiquitination", Lys, 254)) + + + + + + + pubmed:22908190 + + a(CONSO:"paired helical filaments") association p(CONSO:"Tau isoform F (441 aa)", pmod(go:0016567 ! "protein ubiquitination", Lys, 257)) + + + + + + + pubmed:22908190 + + a(CONSO:"paired helical filaments") association p(CONSO:"Tau isoform F (441 aa)", pmod(go:0016567 ! "protein ubiquitination", Lys, 311)) + + + + + + + pubmed:22908190 + + a(CONSO:"paired helical filaments") association p(CONSO:"Tau isoform F (441 aa)", pmod(go:0016567 ! "protein ubiquitination", Lys, 317)) + + + + + + + pubmed:22908190 + + a(CONSO:"paired helical filaments") association p(CONSO:"Tau isoform F (441 aa)", pmod(go:0070936 ! "protein K48-linked ubiquitination")) + + + + + + + pubmed:22908190 + + a(CONSO:"paired helical filaments") association p(CONSO:"Tau isoform F (441 aa)", pmod(go:0070936 ! "protein K48-linked ubiquitination")) + + + + + + + pubmed:22908190 + + a(CONSO:"paired helical filaments") association p(CONSO:"Tau isoform F (441 aa)", pmod(go:0000209 ! "protein polyubiquitination", Lys, 6)) + + + + + + + pubmed:22908190 + + a(CONSO:"paired helical filaments") association p(CONSO:"Tau isoform F (441 aa)", pmod(go:0000209 ! "protein polyubiquitination", Lys, 11)) + + + + + + + + + pubmed:26631930 + + a(CONSO:"paired helical filaments") association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) + + + + + + + pubmed:26631930 + + a(CONSO:"paired helical filaments") association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 394)) + + + + + + + pubmed:26631930 + + a(CONSO:"paired helical filaments") association p(HGNC:MAPT, pmod(CONSO:glycation)) + + + + + + + pubmed:26631930 + + a(CONSO:"paired helical filaments") association p(HGNC:MAPT, pmod(CONSO:deamidation)) + + + + + + + pubmed:26631930 + + a(CONSO:"paired helical filaments") association p(HGNC:MAPT, pmod(GO:"protein peptidyl-prolyl isomerization")) + + + + + + + pubmed:17050703 + + a(CONSO:"paired helical filaments") association p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) + + + + + + + pubmed:16566606 + + a(CONSO:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) + + + + + + + pubmed:16566606 + + a(CONSO:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 18)) + + + + + + + pubmed:16566606 + + a(CONSO:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 197)) + + + + + + + pubmed:16566606 + + a(CONSO:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 394)) + + + + + + + pubmed:16566606 + + a(CONSO:"paired helical filaments") positiveCorrelation a(CONSO:"3-3 dityrosine cross-linking") + + + + + + + pubmed:26501932 + + a(CONSO:"paired helical filaments") partOf a(CONSO:pretangles) + + + + + + + pubmed:7667312 + + a(CONSO:"paired helical filaments") positiveCorrelation a(CONSO:"Thioflavin S") + + + + + + + pubmed:7667312 + + a(CONSO:"paired helical filaments") partOf complex(GO:"neurofibrillary tangle") + + + + + + + pubmed:8391280 + + a(CONSO:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination", Lys, 254)) + + + + + + + pubmed:8391280 + + a(CONSO:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination", Lys, 257)) + + + + + + + pubmed:8391280 + + a(CONSO:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination", Lys, 311)) + + + + + + + + + pubmed:25478017 + + a(CONSO:"Tau antibody, HT7") increases complex(a(CONSO:"Tau antibody, HT7"), a(CONSO:"Tau fibrils")) + + + + + + + pubmed:28408124 + + a(CONSO:"Tau antibody, HT7") decreases p(MGI:Mapt, loc(GO:cell)) + + + + + + + pubmed:28408124 + + a(CONSO:"Tau antibody, HT7") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:28408124 + + a(CONSO:"Tau antibody, HT7") decreases p(HGNC:MAPT, loc(GO:cell)) + + + + + + + pubmed:28408124 + + a(CONSO:"Tau antibody, HT7") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + + + pubmed:25478017 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 214)) increases complex(a(CONSO:"Tau fibrils"), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 214))) + + + + + + + pubmed:25478017 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 214)) decreases a(CONSO:"Tau fibrils") + + + + + + + pubmed:26751493 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 214)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:8226987 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 214)) decreases complex(a(MESH:Microtubules), p(HGNC:MAPT)) + + + + + + + pubmed:25478017 + + path(HP:"Sensorimotor neuropathy") negativeCorrelation a(CONSO:AADvac1) + + + + + + + pubmed:30106381 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases a(GO:"dendritic spine") + + + + + + + pubmed:30106381 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases a(GO:"dendritic spine") + + + + + + + pubmed:30106381 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases a(GO:"dendritic spine") + + + + + + + pubmed:30106381 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases a(GO:"dendritic spine") + + + + + + + pubmed:30664622 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases a(GO:"dendritic spine") + + + + + + + pubmed:30106381 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:DLG4) + + + + + + + pubmed:30106381 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:DLG4) + + + + + + + pubmed:30106381 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases a(GO:"excitatory synapse") + + + + + + + pubmed:30106381 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases a(GO:"excitatory synapse") + + + + + + + + + pubmed:30106381 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) regulates complex(p(HGNC:ADNP), p(HGNC:DLG4)) + + + + + + + pubmed:30106381 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) regulates complex(p(HGNC:ADNP), p(HGNC:AKT1)) + + + + + + + pubmed:30106381 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases p(HGNC:FPR3) + + + + + + + pubmed:30106381 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:TUBB1) + + + + + + + pubmed:30106381 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) regulates act(p(HGNC:LIPA)) + + + + + + + pubmed:30106381 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases p(HGNC:HIST1H3B) + + + + + + + pubmed:30106381 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) regulates p(HGNC:HIST1H3B) + + + + + + + pubmed:30106381 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:ABCF3) + + + + + + + pubmed:30106381 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:BMP4) + + + + + + + pubmed:30106381 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:CDH17) + + + + + + + pubmed:30106381 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:KDM5D) + + + + + + + pubmed:30106381 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:KLF1) + + + + + + + pubmed:30106381 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:PER1) + + + + + + + pubmed:30106381 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:AKT1) + + + + + + + pubmed:30106381 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:AIF1) + + + + + + + pubmed:30106381 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases path(MESH:"Psychomotor Performance") + + + + + + + pubmed:30106381 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases path(MESH:"Psychomotor Performance") + + + + + + + pubmed:30106381 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Vestibular Diseases") + + + + + + + pubmed:30106381 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) negativeCorrelation bp(MESH:"Body Height") + + + + + + + pubmed:30106381 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) negativeCorrelation path(MESH:"Weight Gain") + + + + + + + pubmed:30106381 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases path(MESH:"Motor Activity") + + + + + + + pubmed:30106381 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange path(MESH:"Motor Activity") + + + + + + + pubmed:30106381 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases bp(MESH:"Hand Strength") + + + + + + + pubmed:30106381 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange bp(MESH:"Hand Strength") + + + + + + + pubmed:30106381 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Autistic Disorder") + + + + + + + pubmed:30106381 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases path(MESH:Smell) + + + + + + + pubmed:30106381 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange path(MESH:Smell) + + + + + + + pubmed:30106381 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases bp(GO:"social behavior") + + + + + + + pubmed:30664622 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases bp(GO:"social behavior") + + + + + + + pubmed:30664622 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases bp(GO:"social behavior") + + + + + + + pubmed:30664622 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases bp(GO:memory) + + + + + + + + + pubmed:30664622 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Motor Skills Disorders") + + + + + + + pubmed:30664622 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Brain Injuries") + + + + + + + pubmed:30664622 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases a(MESH:"Nerve Fibers, Myelinated") + + + + + + + pubmed:30664622 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange p(HGNC:SLC17A7) + + + + + + + pubmed:30664622 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases p(HGNC:SLC17A7) + + + + + + + pubmed:30664622 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases p(HGNC:SLC17A7) + + + + + + + pubmed:30664622 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases r(HGNC:SLC17A7) + + + + + + + pubmed:30008470 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases r(HGNC:ADNP) + + + + + + + pubmed:30008470 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Alcohol Drinking") + + + + + + + pubmed:30008470 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange path(MESH:"Alcohol Drinking") + + + + + + + pubmed:30008470 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Alcohol Drinking") + + + + + + + pubmed:30008470 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Alcohol Drinking") + + + + + + + pubmed:30008470 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases path(MESH:"Alcohol Drinking") + + + + + + + pubmed:30008470 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange tloc(a(CHEBI:saccharin), fromLoc(GO:"extracellular space"), toLoc(GO:intracellular)) + + + + + + + pubmed:30008470 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange tloc(a(CHEBI:quinine), fromLoc(GO:"extracellular space"), toLoc(GO:intracellular)) + + + + + + + pubmed:30008470 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:TFAP2B) + + + + + + + pubmed:30008470 + + p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases p(HGNC:TFAP2B) + + + + + + + pubmed:30106381 + + composite(a(PUBCHEM:9832404), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) decreases a(GO:"dendritic spine") + + + + + + + pubmed:30106381 + + composite(a(PUBCHEM:9832404), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) decreases path(MESH:"Recognition (Psychology)") + + + + + + + pubmed:30664622 + + composite(a(PUBCHEM:9832404), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) increases path(MESH:Smell) + + + + + + + pubmed:30664622 + + composite(a(PUBCHEM:9832404), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) decreases path(MESH:Smell) + + + + + + + pubmed:30008470 + + composite(a(PUBCHEM:9832404), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) decreases path(MESH:"Alcohol Drinking") + + + + + + + pubmed:30106381 + + bp(GO:"AMPA glutamate receptor clustering") association p(HGNC:ADNP) + + + + + + + pubmed:30106381 + + bp(GO:"social behavior") association p(HGNC:ADNP) + + + + + + + pubmed:30106381 + + bp(GO:"vocalization behavior") association p(HGNC:ADNP) + + + + + + + pubmed:30106381 + + p(HGNC:AKT1, var("?")) increases path(MESH:"Proteus Syndrome") + + + + + + + pubmed:30106381 + + g(HGNC:IQCJ-SCHIP1) increases bp(GO:"calcium-mediated signaling") + + + + + + + pubmed:30106381 + + g(HGNC:IQCJ-SCHIP1) increases bp(GO:"action potential") + + + + + + + pubmed:30106381 + + g(HGNC:IQCJ-SCHIP1) increases bp(MESH:"Neuronal Outgrowth") + + + + + + + pubmed:30106381 + + g(HGNC:IQCJ-SCHIP1) association p(HGNC:ADNP) + + + + + + + pubmed:30106381 + + g(HGNC:IQCJ-SCHIP1) association a(PUBCHEM:9832404) + + + + + + + pubmed:30106381 + + p(HGNC:LIPA) increases bp(GO:"lipid metabolic process") + + + + + + + pubmed:22142809 + + p(HGNC:LIPA) negativeCorrelation p(CONSO:RAC1b) + + + + + + + pubmed:22142809 + + p(HGNC:LIPA) association bp(GO:"regulation of cell cycle") + + + + + + + pubmed:30106381 + + g(HGNC:LIPA) association a(PUBCHEM:9832404) + + + + + + + pubmed:30106381 + + p(HGNC:NLGN2) association a(PUBCHEM:9832404) + + + + + + + pubmed:30106381 + + p(HGNC:NLGN2) association p(HGNC:ADNP) + + + + + + + pubmed:30106381 + + p(HGNC:NLGN2) increases bp(GO:"synapse organization") + + + + + + + pubmed:30106381 + + p(HGNC:PAX6) association a(PUBCHEM:9832404) + + + + + + + pubmed:30106381 + + p(HGNC:PAX6) regulates bp(GO:"glutamatergic neuron differentiation") + + + + + + + pubmed:30106381 + + p(HGNC:WFS1) association path(CONSO:Neurodegeneration) + + + + + + + pubmed:30106381 + + p(HGNC:WFS1) regulates bp(GO:"cellular calcium ion homeostasis") + + + + + + + pubmed:30106381 + + p(HGNC:WFS1) association p(HGNC:ADNP) + + + + + + + pubmed:30106381 + + path(MESH:Intelligence) association p(HGNC:ADNP) + + + + + + + pubmed:30106381 + + p(HGNC:AIF1) association bp(GO:"microglial cell activation") + + + + + + + pubmed:26010758 + + p(HGNC:AIF1) positiveCorrelation bp(GO:"microglial cell activation") + + + + + + + pubmed:30106381 + + bp(MESH:"Body Height") negativeCorrelation p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) + + + + + + + pubmed:30106381 + + path(MESH:"Weight Gain") negativeCorrelation p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) + + + + + + + pubmed:30664622 + + path(MESH:Smell) regulates bp(GO:"social behavior") + + + + + + + pubmed:30664622 + + a(CHEBI:chlorobutanol) increases tloc(a(PUBCHEM:9832404), fromLoc(GO:"extracellular region"), toLoc(MESH:Brain)) + + + + + + + pubmed:30664622 + + a(CHEBI:chlorobutanol) increases tloc(a(PUBCHEM:9832404), fromLoc(GO:"extracellular region"), toLoc(MESH:"Cell Body")) + + + + + + + pubmed:30664622 + + a(CHEBI:chlorobutanol) increases tloc(a(PUBCHEM:9832404), fromLoc(GO:"extracellular region"), toLoc(MESH:Brain)) + + + + + + + pubmed:30664622 + + a(CHEBI:chlorobutanol) causesNoChange a(MESH:"Blood-Brain Barrier") + + + + + + + + + pubmed:30664622 + + a(CHEBI:chlorobutanol) increases bp(GO:"social behavior") + + + + + + + pubmed:30664622 + + a(CHEBI:chlorobutanol) causesNoChange path(MESH:Smell) + + + + + + + pubmed:30664622 + + a(CHEBI:chlorobutanol) decreases path(MESH:Smell) + + + + + + + + + pubmed:30664622 + + a(CHEBI:"Evans blue") causesNoChange tloc(a(PUBCHEM:9832404), fromLoc(GO:"extracellular region"), toLoc(MESH:Brain)) + + + + + + + pubmed:30664622 + + a(CHEBI:"Evans blue") increases tloc(a(PUBCHEM:9832404), fromLoc(GO:"extracellular region"), toLoc(GO:"cell periphery")) + + + + + + + pubmed:30664622 + + a(CHEBI:"Evans blue") causesNoChange tloc(a(PUBCHEM:9832404), fromLoc(GO:"extracellular region"), toLoc(MESH:Brain)) + + + + + + + pubmed:30664622 + + composite(a(CHEBI:chlorobutanol), a(PUBCHEM:9832404)) increases bp(GO:memory) + + + + + + + pubmed:30664622 + + composite(a(CHEBI:chlorobutanol), a(PUBCHEM:9832404)) increases bp(GO:"social behavior") + + + + + + + pubmed:30664622 + + composite(a(CHEBI:chlorobutanol), a(PUBCHEM:9832404)) increases a(MESH:"Nerve Fibers, Myelinated") + + + + + + + pubmed:30664622 + + composite(a(PUBCHEM:59557), a(PUBCHEM:9832404)) decreases bp(GO:"social behavior") + + + + + + + + + pubmed:30664622 + + composite(a(CHEBI:chlorobutanol), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) decreases path(MESH:Smell) + + + + + + + pubmed:30664622 + + composite(a(CHEBI:chlorobutanol), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) increases path(MESH:Smell) + + + + + + + pubmed:30664622 + + p(HGNC:SLC17A7) regulates bp(GO:"glutamate homeostasis") + + + + + + + pubmed:30664622 + + p(HGNC:SLC17A7) increases bp(GO:"L-glutamate import") + + + + + + + pubmed:30664622 + + p(HGNC:SLC17A7) association a(GO:"asymmetric, glutamatergic, excitatory synapse") + + + + + + + + + pubmed:30664622 + + a(GO:"asymmetric, glutamatergic, excitatory synapse") association p(HGNC:SLC17A7) + + + + + + + pubmed:29724491 + + p(HGNC:ADNP, frag("1_719")) decreases bp(GO:"walking behavior") + + + + + + + pubmed:29724491 + + p(HGNC:ADNP, var("?")) increases path(MESH:"Muscle Hypotonia") + + + + + + + pubmed:29724491 + + p(HGNC:ADNP, var("?")) increases path(MESH:"Muscle Hypertonia") + + + + + + + pubmed:29724491 + + p(HGNC:ADNP, var("?")) increases path(MESH:"Language Development Disorders") + + + + + + + pubmed:29724491 + + p(HGNC:ADNP, var("?")) increases path(MESH:Seizures) + + + + + + + pubmed:29724491 + + p(HGNC:ADNP, var("?")) increases path(MESH:Epilepsy) + + + + + + + pubmed:29724491 + + p(HGNC:ADNP, var("?")) increases path(MESH:"Autistic Disorder") + + + + + + + pubmed:29724491 + + p(HGNC:ADNP, var("?")) decreases path(MESH:"Autism Spectrum Disorder") + + + + + + + pubmed:29724491 + + p(HGNC:ADNP, var("?")) decreases bp(GO:"sensory processing") + + + + + + + pubmed:29724491 + + p(HGNC:ADNP, var("?")) increases path(MESH:"Compulsive Behavior") + + + + + + + pubmed:29724491 + + p(HGNC:ADNP, var("?")) association path(MESH:"Mood Disorders") + + + + + + + pubmed:29724491 + + p(HGNC:ADNP, var("?")) increases path(MESH:Anxiety) + + + + + + + pubmed:29724491 + + p(HGNC:ADNP, var("?")) association path(MESH:Morale) + + + + + + + pubmed:29724491 + + p(HGNC:ADNP, var("?")) association path(MESH:"Self-Injurious Behavior") + + + + + + + pubmed:29724491 + + p(HGNC:ADNP, var("?")) association path(MESH:Aggression) + + + + + + + pubmed:29724491 + + p(HGNC:ADNP, var("?")) increases path(MESH:"Attention Deficit Disorder with Hyperactivity") + + + + + + + pubmed:29724491 + + p(HGNC:ADNP, var("?")) decreases bp(GO:sleep) + + + + + + + pubmed:29724491 + + p(HGNC:ADNP, var("?")) increases path(MESH:"Malformations of Cortical Development") + + + + + + + pubmed:29724491 + + p(HGNC:ADNP, var("?")) decreases path(MESH:"Vision, Ocular") + + + + + + + pubmed:29724491 + + p(HGNC:ADNP, var("?")) increases path(MESH:Hyperopia) + + + + + + + pubmed:29724491 + + p(HGNC:ADNP, var("?")) increases path(MESH:Strabismus) + + + + + + + pubmed:29724491 + + p(HGNC:ADNP, var("?")) increases path(MESH:Myopia) + + + + + + + pubmed:29724491 + + p(HGNC:ADNP, var("?")) increases path(MESH:Astigmatism) + + + + + + + pubmed:29724491 + + path(MESH:Morale) association p(HGNC:ADNP, var("?")) + + + + + + + pubmed:29724491 + + path(MESH:"Self-Injurious Behavior") association p(HGNC:ADNP, var("?")) + + + + + + + pubmed:29724491 + + path(MESH:Aggression) association p(HGNC:ADNP, var("?")) + + + + + + + pubmed:30008470 + + path(MESH:"Alcohol Drinking") increases r(HGNC:ADNP) + + + + + + + pubmed:30008470 + + path(MESH:"Alcohol Drinking") increases r(HGNC:ADNP) + + + + + + + pubmed:30008470 + + path(MESH:"Alcohol Drinking") increases p(HGNC:ADNP) + + + + + + + pubmed:30008470 + + path(MESH:"Alcohol Drinking") causesNoChange p(HGNC:ADNP) + + + + + + + pubmed:30008470 + + path(MESH:"Alcohol Drinking") causesNoChange p(HGNC:ADNP) + + + + + + + pubmed:30008470 + + path(MESH:"Alcohol Drinking") decreases p(HGNC:ADNP) + + + + + + + pubmed:30008470 + + path(MESH:"Alcohol Drinking") causesNoChange p(HGNC:ADNP) + + + + + + + pubmed:30008470 + + path(MESH:"Alcohol Drinking") negativeCorrelation g(HGNC:ADNP) + + + + + + + pubmed:30008470 + + path(MESH:"Alcohol Drinking") decreases p(HGNC:TFAP2B) + + + + + + + pubmed:30008470 + + g(HGNC:ADNP) negativeCorrelation path(MESH:"Alcohol Drinking") + + + + + + + pubmed:22807490 + + path(MESH:"Hashimoto Disease") association path(MESH:Smoking) + + + + + + + pubmed:22807490 + + p(HGNC:TPO) negativeCorrelation path(MESH:Smoking) + + + + + + + pubmed:22807490 + + path(MESH:"Thyroiditis, Autoimmune") increases p(HGNC:IL1R2) + + + + + + + pubmed:22807490 + + path(MESH:"Thyroiditis, Autoimmune") increases p(HGNC:IL18) + + + + + + + pubmed:21958873 + + a(PUBCHEM:71311633) causesNoChange a(CHEBI:amyloid-beta) + + + + + + + pubmed:21958873 + + a(PUBCHEM:71311633) increases act(a(MESH:"Receptors, Nicotinic")) + + + + + + + pubmed:21958873 + + a(PUBCHEM:56972222) causesNoChange a(CHEBI:amyloid-beta) + + + + + + + pubmed:21958873 + + a(PUBCHEM:56972222) increases act(a(MESH:"Receptors, Nicotinic")) + + + + + + + pubmed:21958873 + + a(PUBCHEM:11957537) causesNoChange a(CHEBI:amyloid-beta) + + + + + + + pubmed:21958873 + + a(PUBCHEM:11957537) decreases act(a(MESH:"Receptors, Nicotinic")) + + + + + + + pubmed:30988501 + + p(HGNC:CRP) negativeCorrelation path(DOID:schizophrenia) + + + + + + + pubmed:30988501 + + p(HGNC:CRP) negativeCorrelation path(DOID:"mental depression") + + + + + + + pubmed:30988501 + + p(HGNC:CRP) negativeCorrelation path(DOID:"post-traumatic stress disorder") + + + + + + + pubmed:23178521 + + a(CHEBI:stattic) decreases p(HGNC:STAT3, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:23178521 + + a(CHEBI:stattic) decreases p(HGNC:STAT3, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:23178521 + + a(CHEBI:stattic) decreases complex(p(HGNC:STAT3), p(HGNC:STAT3)) + + + + + + + pubmed:23178521 + + a(CHEBI:stattic) decreases p(HGNC:RELA, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:23178521 + + composite(a(CHEBI:Anatabine), a(MESH:Blood)) decreases p(HGNC:IL1B) + + + + + + + + + + + pubmed:23178521 + + composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide), a(MESH:Blood)) decreases p(HGNC:IL1B) + + + + + + + pubmed:23383175 + + p(MGI:Il1b) positiveCorrelation path(MESH:Encephalomyelitis) + + + + + + + pubmed:23383175 + + p(MGI:Il6) positiveCorrelation path(MESH:Encephalomyelitis) + + + + + + + pubmed:23383175 + + p(MGI:Tnf) positiveCorrelation path(MESH:Encephalomyelitis) + + + + + + + pubmed:23178521 + + composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Il1b) + + + + + + + pubmed:23178521 + + composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Il1b) + + + + + + + pubmed:23178521 + + composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Tnf) + + + + + + + pubmed:23178521 + + composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Tnf) + + + + + + + pubmed:23178521 + + composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Tnf) + + + + + + + pubmed:23178521 + + composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Il6) + + + + + + + pubmed:23178521 + + composite(a(CHEBI:Anatabine), a(CHEBI:lipopolysaccharide)) decreases p(MGI:Il6) + + + + + + + pubmed:23383175 + + p(MGI:Stat3, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation path(MESH:Encephalomyelitis) + + + + + + + pubmed:23383175 + + p(MGI:Stat3, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation path(MESH:Encephalomyelitis) + + + + + + + pubmed:23383175 + + p(MGI:Stat3, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation path(MESH:Encephalomyelitis) + + + + + + + pubmed:23383175 + + p(MGI:Stat3, pmod(go:0006468 ! "protein phosphorylation")) association path(MESH:"Neurologic Manifestations") + + + + + + + pubmed:23383175 + + p(MGI:Stat3, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation p(MGI:Rela, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + + + pubmed:23383175 + + p(MGI:Stat3) regulates bp(GO:"cytokine production") + + + + + + + pubmed:23383175 + + path(MESH:Encephalomyelitis) negativeCorrelation a(CHEBI:Anatabine) + + + + + + + pubmed:23383175 + + path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Il1b) + + + + + + + pubmed:23383175 + + path(MESH:Encephalomyelitis) increases p(MGI:Il1b) + + + + + + + pubmed:23383175 + + path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Ifng) + + + + + + + pubmed:23383175 + + path(MESH:Encephalomyelitis) increases p(MGI:Ifng) + + + + + + + pubmed:23383175 + + path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Tnf) + + + + + + + pubmed:23383175 + + path(MESH:Encephalomyelitis) increases p(MGI:Tnf) + + + + + + + pubmed:23383175 + + path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Il6) + + + + + + + pubmed:23383175 + + path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Il17a) + + + + + + + pubmed:23383175 + + path(MESH:Encephalomyelitis) increases p(MGI:Stat3, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:23383175 + + path(MESH:Encephalomyelitis) increases p(MGI:Stat3, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:23383175 + + path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Stat3, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:23383175 + + path(MESH:Encephalomyelitis) increases p(MGI:Stat3, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:23383175 + + path(MESH:Encephalomyelitis) increases p(MGI:Stat3, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:23383175 + + path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Stat3, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:23383175 + + path(MESH:Encephalomyelitis) positiveCorrelation p(MGI:Stat3, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:23383175 + + path(MESH:Encephalomyelitis) increases p(MGI:Rela, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:23383175 + + path(MESH:Encephalomyelitis) increases bp(CONSO:Astrogliosis) + + + + + + + pubmed:23383175 + + path(MESH:Encephalomyelitis) increases bp(CONSO:Astrogliosis) + + + + + + + pubmed:23383175 + + path(MESH:Encephalomyelitis) increases bp(CONSO:Microgliosis) + + + + + + + pubmed:23383175 + + path(MESH:Encephalomyelitis) increases tloc(a(MESH:Leukocytes), fromLoc(GO:"extracellular region"), toLoc(MESH:"Spinal Cord")) + + + + + + + pubmed:23383175 + + path(MESH:Encephalomyelitis) increases a(MESH:Microglia) + + + + + + + pubmed:23383175 + + path(MESH:Encephalomyelitis) decreases a(GO:"myelin sheath") + + + + + + + pubmed:23383175 + + p(MGI:Ifng) positiveCorrelation path(MESH:Encephalomyelitis) + + + + + + + pubmed:23383175 + + p(MGI:Il17a) positiveCorrelation path(MESH:Encephalomyelitis) + + + + + + + pubmed:23383175 + + p(MGI:Rela, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation p(MGI:Stat3, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + + + pubmed:23383175 + + p(MGI:Rela) regulates bp(GO:"cytokine production") + + + + + + + pubmed:23383175 + + bp(CONSO:Astrogliosis) negativeCorrelation a(GO:"myelin sheath") + + + + + + + pubmed:23383175 + + bp(CONSO:Microgliosis) negativeCorrelation a(GO:"myelin sheath") + + + + + + + pubmed:12428809 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396), pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) association path(MESH:"Alzheimer Disease") + + + + + + + pubmed:21882945 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396), pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + doi:"10.4172/2168-975X.1000126" + + p(FPLX:AKT, pmod(go:0006468 ! "protein phosphorylation", Ser, 473)) increases act(p(FPLX:AKT)) + + + + + + + pubmed:23454242 + + p(FPLX:AKT, pmod(go:0006468 ! "protein phosphorylation", Ser, 473)) increases act(p(FPLX:AKT)) + + + + + + + pubmed:29121589 + + p(FPLX:AKT, pmod(go:0006468 ! "protein phosphorylation", Ser, 473)) increases act(p(FPLX:AKT)) + + + + + + + pubmed:29121589 + + p(FPLX:AKT, pmod(go:0006468 ! "protein phosphorylation", Ser, 473)) positiveCorrelation a(CHEBI:"dimethyl fumarate") + + + + + + + pubmed:28391535 + + tloc(a(CHEBI:adrenaline), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) increases tloc(a(CHEBI:glucose), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:28391535 + + tloc(a(CHEBI:adrenaline), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) increases path(MESH:"Blood Pressure") + + + + + + + pubmed:28391535 + + tloc(a(CHEBI:adrenaline), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) increases bp(GO:"cellular respiration") + + + + + + + pubmed:28391535 + + tloc(a(CHEBI:adrenaline), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) increases bp(MESH:"Heart Rate") + + + + + + + pubmed:28391535 + + complex(p(GO:"I-kappaB/NF-kappaB complex")) association a(CHEBI:nicotine) + + + + + + + + + + + + + + + pubmed:28391535 + + a(CHEBI:"(S)-nicotine") increases a(MESH:"Toxic Actions") + + + + + + + pubmed:28391535 + + a(CHEBI:"(S)-nicotine") increases path(MESH:Death) + + + + + + + pubmed:28391535 + + a(CHEBI:"(R)-nicotine") increases a(MESH:"Toxic Actions") + + + + + + + pubmed:28391535 + + a(CHEBI:"(R)-nicotine") increases path(MESH:Death) + + + + + + + pubmed:28391535 + + a(MESH:Tobacco) isA a(CHEBI:nornicotine) + + + + + + + + + pubmed:28391535 + + a(MESH:Liver) increases bp(GO:"nicotine metabolic process") + + + + + + + pubmed:29626319 + + a(MESH:Liver) increases deg(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:29626319 + + a(MESH:Liver) decreases a(CHEBI:amyloid-beta) + + + + + + + pubmed:29626319 + + a(MESH:Liver) decreases a(CHEBI:amyloid-beta) + + + + + + + pubmed:29626319 + + a(MESH:Liver) decreases a(CHEBI:"amyloid-beta polypeptide 40") + + + + + + + pubmed:29626319 + + a(MESH:Liver) causesNoChange a(CHEBI:"amyloid-beta polypeptide 42") + + + + + + + pubmed:28391535 + + bp(GO:"nicotine metabolic process") increases a(CHEBI:"(-)-cotinine") + + + + + + + pubmed:28391535 + + bp(GO:"nicotine metabolic process") increases a(CHEBI:nornicotine) + + + + + + + pubmed:28391535 + + a(MESH:Lung) increases bp(GO:"nicotine metabolic process") + + + + + + + pubmed:28391535 + + a(CHEBI:lactam) association a(CHEBI:"(-)-cotinine") + + + + + + + + + pubmed:26195256 + + path(MESH:Hypertension) increases path(MESH:"Alzheimer Disease") + + + + + + + pubmed:28391535 + + a(PUBCHEM:4032) decreases path(MESH:"Behavior, Addictive") + + + + + + + pubmed:28391535 + + a(PUBCHEM:4032) decreases path(MESH:Smoking) + + + + + + + pubmed:28391535 + + a(CHEBI:Hexamethonium) increases tloc(a(CHEBI:Hexamethonium), fromLoc(GO:"extracellular region"), toLoc(MESH:"Central Nervous System")) + + + + + + + pubmed:28391535 + + a(CHEBI:Hexamethonium) negativeCorrelation act(a(CHEBI:nicotine)) + + + + + + + + + pubmed:28391535 + + a(CHEBI:"(-)-lobeline") increases complex(a(CHEBI:"(-)-lobeline"), a(MESH:"nicotinic receptor alpha4beta2")) + + + + + + + pubmed:28391535 + + a(CHEBI:"(-)-lobeline") decreases act(a(CHEBI:nicotine)) + + + + + + + pubmed:28391535 + + a(CHEBI:"(-)-lobeline") decreases act(a(PUBCHEM:9306)) + + + + + + + pubmed:19165623 + + complex(a(CHEBI:"nicotinic acid"), a(CHEBI:1-methylpyrrolinium)) increases a(CHEBI:nicotine) + + + + + + + + + + + pubmed:19165623 + + a(CHEBI:arginine) increases a(CHEBI:1-methylpyrrolinium) + + + + + + + pubmed:19165623 + + a(CHEBI:ornithine) increases a(CHEBI:1-methylpyrrolinium) + + + + + + + pubmed:19165623 + + a(UNIPROT:Q9SEH4) increases a(CHEBI:nicotine) + + + + + + + pubmed:19165623 + + a(UNIPROT:Q9SEH4) increases a(CHEBI:nicotine) + + + + + + + pubmed:19165623 + + a(UNIPROT:Q9SEH4) increases rxn(reactants(a(CHEBI:arginine), a(CHEBI:ornithine)), products(a(CHEBI:1-methylpyrrolinium))) + + + + + + + pubmed:19165623 + + a(UNIPROT:Q9SEH4) decreases a(CHEBI:Anatabine) + + + + + + + + + + + + + pubmed:19165623 + + p(HGNC:QPRT) increases rxn(reactants(a(CHEBI:"quinolinic acid")), products(a(CHEBI:"nicotinic acid"))) + + + + + + + pubmed:19165623 + + p(HGNC:QPRT) regulates rxn(reactants(a(CHEBI:"nicotinic acid")), products(a(CHEBI:Anatabine))) + + + + + + + pubmed:19165623 + + p(HGNC:QPRT) increases a(CHEBI:Anatabine) + + + + + + + pubmed:19165623 + + p(HGNC:QPRT) increases a(CHEBI:nicotine) + + + + + + + + + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases act(p(HGNC:NFE2L2)) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases act(p(HGNC:NFE2L2)) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases act(p(HGNC:NFE2L2)) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:SIRT1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:SLC7A11) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:AKR1B10) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:PTGR1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:HMOX1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:HMOX1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:HMOX1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:AIFM2) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:OSGIN1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:GPX3) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:SQSTM1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:HSPB8) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:TNFSF9) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:CTNNB1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:DHFR) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:DHFR) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:EDN1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:ITGB3) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:MKI67) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:MMP11) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:MMP14) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:MMP2) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:PDE7A) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:PDE7B) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:PLAU) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:PTGS1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:PTGS1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:SCARB1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:TUBB3) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:TUBB3) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:TUBB3) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:NR3C1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:NR3C1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:PPARA) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:PPARA) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:EGR1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:PTGS2) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:PTGS2) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:SOAT1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:ACLY) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:ACLY) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:ANTXR1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:C20orf27) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:CCNA2) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:CHAF1A) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:EFCAB11) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:FEN1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:GINS2) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:MCM10) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:MCM4) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:RNASEH2A) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:SLIT2) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:SPC25) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:TFRC) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:TK1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:TMEM97) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:TRIP13) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:TUBB) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:TUBB) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:TYMS) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:UBA1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:UNG) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:UNG) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:VRK1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:ABCD3) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:GLRX2) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:GLRX2) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:MICB) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:NQO1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:NQO1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:NQO1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases p(HGNC:TYMS) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:AGRN) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:ANP32A) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:BAX) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:BCHE) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:BGN) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:BRCA1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:CADPS2) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:CAPN1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:CCNB1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:CDK1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:CDK2) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:CDKN2A) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:CXCR4) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:EIF4EBP1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:FOLH1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:HOMER1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:HRH1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:IGF2) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:IGFBP2) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:LDLR) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:MAOA) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:NEFH) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:NPDC1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:NRGN) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:PREP) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:PROS1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:SELENBP1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:TAGLN) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:TGFB1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:VKORC1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:CANX) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:GCNT2) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:IDE) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:MMP1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:NFE2L2) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:SLC6A6) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:SYVN1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:TSHZ1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:TXN) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:ATAD2) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:BECN1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:DHCR24) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:FGF2) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:HTRA1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:PRKCE) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:PRKDC) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) decreases g(HGNC:SCD) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:ATP1A1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:CTSD) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:GLRX) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:GLRX) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:IL6R) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:NPTX1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:PHF1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:PRKCD) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:RANBP9) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:SOD1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:135316034) increases g(HGNC:SOD1) + + + + + + + pubmed:22020111 + + a(PUBCHEM:400769) increases act(p(HGNC:NFE2L2)) + + + + + + + pubmed:22020111 + + a(PUBCHEM:400769) increases act(p(HGNC:NFE2L2)) + + + + + + + pubmed:22020111 + + a(PUBCHEM:400769) increases act(p(HGNC:NFE2L2)) + + + + + + + pubmed:22020111 + + a(PUBCHEM:400769) increases act(p(HGNC:NFE2L2)) + + + + + + + pubmed:22020111 + + a(PUBCHEM:400769) increases bp(GO:"glomerular filtration") + + + + + + + pubmed:22020111 + + a(PUBCHEM:400769) negativeCorrelation path(MESH:"Multiple Sclerosis, Relapsing-Remitting") + + + + + + + pubmed:22020111 + + p(HGNC:SLC7A11) regulates bp(GO:"glutamate homeostasis") + + + + + + + pubmed:22020111 + + p(HGNC:SLC7A11) increases tloc(a(CHEBI:cystine), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + + + pubmed:30837838 + + a(CHEBI:glutathione) decreases deg(p(HGNC:TARDBP)) + + + + + + + pubmed:30837838 + + a(CHEBI:glutathione) decreases p(HGNC:TARDBP, frag("?"), loc(GO:"cortical granule")) + + + + + + + pubmed:30837838 + + a(CHEBI:glutathione) decreases p(CONSO:"TDP-43 aggregates") + + + + + + + pubmed:30837838 + + a(CHEBI:glutathione) decreases a(CHEBI:"reactive oxygen species") + + + + + + + pubmed:30837838 + + a(CHEBI:glutathione) decreases path(MESH:"Cell Death") + + + + + + + pubmed:22020111 + + p(HGNC:AKR1B10) increases bp(GO:detoxification) + + + + + + + pubmed:22020111 + + p(HGNC:AKR1B10) decreases a(PUBCHEM:5283344) + + + + + + + pubmed:22020111 + + p(HGNC:PTGR1) decreases act(a(MESH:Prostaglandins)) + + + + + + + pubmed:22020111 + + p(HGNC:PTGR1) decreases act(a(MESH:Eicosanoids)) + + + + + + + pubmed:22020111 + + g(HGNC:HMOX1) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:22020111 + + p(HGNC:AIFM2) increases path(MESH:Apoptosis) + + + + + + + pubmed:22020111 + + p(HGNC:AIFM2) negativeCorrelation path(MESH:Neoplasms) + + + + + + + pubmed:28669544 + + path(MESH:Apoptosis) increases a(NCIT:C120869) + + + + + + + pubmed:22020111 + + p(HGNC:OSGIN1) decreases path(MESH:Neoplasms) + + + + + + + pubmed:22020111 + + p(HGNC:GPX3) negativeCorrelation path(MESH:Neoplasms) + + + + + + + + + pubmed:22020111 + + p(HGNC:HSPB8) increases complex(p(HGNC:BAG3), p(HGNC:HSPB8)) + + + + + + + pubmed:27491084 + + p(HGNC:HSPB8) association a(CONSO:"amyloid-beta aggregates") + + + + + + + pubmed:24563850 + + p(HGNC:HSPB8) increases bp(GO:"chaperone-mediated autophagy") + + + + + + + pubmed:24563850 + + p(HGNC:HSPB8) association p(HGNC:EIF2A) + + + + + + + pubmed:22020111 + + complex(p(HGNC:BAG3), p(HGNC:HSPB8)) positiveCorrelation bp(GO:autophagy) + + + + + + + pubmed:22020111 + + complex(p(HGNC:BAG3), p(HGNC:HSPB8)) increases deg(a(CONSO:"protein aggregates")) + + + + + + + + + pubmed:25036637 + + p(HGNC:BAG3) increases complex(p(HGNC:BAG3), p(HGNC:HSPB8)) + + + + + + + + + pubmed:23746257 + + p(HGNC:BAG3) increases bp(GO:macroautophagy) + + + + + + + + + pubmed:25036637 + + p(HGNC:BAG3) increases complex(p(HGNC:BAG3), p(HGNC:HSPB1)) + + + + + + + pubmed:25036637 + + p(HGNC:BAG3) directlyIncreases complex(p(HGNC:BAG3), p(HGNC:HSPB1)) + + + + + + + + + pubmed:25036637 + + p(HGNC:BAG3) increases complex(p(HGNC:BAG3), p(HGNC:HSF1)) + + + + + + + + + + + pubmed:25036637 + + p(HGNC:BAG3) directlyIncreases complex(p(HGNC:BAG3), p(HGNC:DCP1B)) + + + + + + + + + pubmed:29626319 + + p(HGNC:BAG3) increases deg(p(HGNC:MAPT)) + + + + + + + pubmed:22020111 + + p(HGNC:TNFSF9) increases act(a(MESH:"Dendritic Cells")) + + + + + + + pubmed:22020111 + + p(HGNC:TNFSF9) increases bp(GO:"T cell activation") + + + + + + + pubmed:22020111 + + path(MESH:Atherosclerosis) increases g(HGNC:CTNNB1) + + + + + + + pubmed:22020111 + + path(MESH:Atherosclerosis) increases g(HGNC:DHFR) + + + + + + + pubmed:22020111 + + path(MESH:Atherosclerosis) increases g(HGNC:EDN1) + + + + + + + pubmed:22020111 + + path(MESH:Atherosclerosis) increases g(HGNC:ITGB3) + + + + + + + pubmed:22020111 + + path(MESH:Atherosclerosis) increases g(HGNC:MKI67) + + + + + + + pubmed:22020111 + + path(MESH:Atherosclerosis) increases g(HGNC:MMP11) + + + + + + + pubmed:22020111 + + path(MESH:Atherosclerosis) increases g(HGNC:MMP14) + + + + + + + pubmed:22020111 + + path(MESH:Atherosclerosis) increases g(HGNC:MMP2) + + + + + + + pubmed:22020111 + + path(MESH:Atherosclerosis) increases g(HGNC:PDE7A) + + + + + + + pubmed:22020111 + + path(MESH:Atherosclerosis) increases g(HGNC:PDE7B) + + + + + + + pubmed:22020111 + + path(MESH:Atherosclerosis) increases g(HGNC:PLAU) + + + + + + + pubmed:22020111 + + path(MESH:Atherosclerosis) increases g(HGNC:PTGS1) + + + + + + + pubmed:22020111 + + path(MESH:Atherosclerosis) increases g(HGNC:SCARB1) + + + + + + + pubmed:22020111 + + path(MESH:Atherosclerosis) increases g(HGNC:TUBB3) + + + + + + + pubmed:22020111 + + path(MESH:Atherosclerosis) decreases g(HGNC:NR3C1) + + + + + + + pubmed:22020111 + + path(MESH:Atherosclerosis) decreases g(HGNC:PPARA) + + + + + + + pubmed:22020111 + + path(MESH:Atherosclerosis) increases g(HGNC:EGR1) + + + + + + + pubmed:22020111 + + path(MESH:Atherosclerosis) increases g(HGNC:PTGS2) + + + + + + + pubmed:22020111 + + path(MESH:Atherosclerosis) increases g(HGNC:SOAT1) + + + + + + + pubmed:22020111 + + path(MESH:"Colorectal Neoplasms") increases g(HGNC:ACLY) + + + + + + + pubmed:22020111 + + path(MESH:"Colorectal Neoplasms") increases g(HGNC:ANTXR1) + + + + + + + pubmed:22020111 + + path(MESH:"Colorectal Neoplasms") increases g(HGNC:C20orf27) + + + + + + + pubmed:22020111 + + path(MESH:"Colorectal Neoplasms") increases g(HGNC:CCNA2) + + + + + + + pubmed:22020111 + + path(MESH:"Colorectal Neoplasms") increases g(HGNC:CHAF1A) + + + + + + + pubmed:22020111 + + path(MESH:"Colorectal Neoplasms") increases g(HGNC:DHFR) + + + + + + + pubmed:22020111 + + path(MESH:"Colorectal Neoplasms") increases g(HGNC:EFCAB11) + + + + + + + pubmed:22020111 + + path(MESH:"Colorectal Neoplasms") increases g(HGNC:FEN1) + + + + + + + pubmed:22020111 + + path(MESH:"Colorectal Neoplasms") increases g(HGNC:GINS2) + + + + + + + pubmed:22020111 + + path(MESH:"Colorectal Neoplasms") increases g(HGNC:MCM10) + + + + + + + pubmed:22020111 + + path(MESH:"Colorectal Neoplasms") increases g(HGNC:MCM4) + + + + + + + pubmed:22020111 + + path(MESH:"Colorectal Neoplasms") increases g(HGNC:RNASEH2A) + + + + + + + pubmed:22020111 + + path(MESH:"Colorectal Neoplasms") increases g(HGNC:SLIT2) + + + + + + + pubmed:22020111 + + path(MESH:"Colorectal Neoplasms") increases g(HGNC:SPC25) + + + + + + + pubmed:22020111 + + path(MESH:"Colorectal Neoplasms") increases g(HGNC:TFRC) + + + + + + + pubmed:22020111 + + path(MESH:"Colorectal Neoplasms") increases g(HGNC:TK1) + + + + + + + pubmed:22020111 + + path(MESH:"Colorectal Neoplasms") increases g(HGNC:TMEM97) + + + + + + + pubmed:22020111 + + path(MESH:"Colorectal Neoplasms") increases g(HGNC:TRIP13) + + + + + + + pubmed:22020111 + + path(MESH:"Colorectal Neoplasms") increases g(HGNC:TUBB) + + + + + + + pubmed:22020111 + + path(MESH:"Colorectal Neoplasms") increases g(HGNC:TUBB3) + + + + + + + pubmed:22020111 + + path(MESH:"Colorectal Neoplasms") increases g(HGNC:TYMS) + + + + + + + pubmed:22020111 + + path(MESH:"Colorectal Neoplasms") increases g(HGNC:UBA1) + + + + + + + pubmed:22020111 + + path(MESH:"Colorectal Neoplasms") increases g(HGNC:UNG) + + + + + + + pubmed:22020111 + + path(MESH:"Colorectal Neoplasms") increases g(HGNC:VRK1) + + + + + + + pubmed:22020111 + + path(MESH:"Colorectal Neoplasms") decreases g(HGNC:ABCD3) + + + + + + + pubmed:22020111 + + path(MESH:"Colorectal Neoplasms") increases g(HGNC:GLRX2) + + + + + + + pubmed:22020111 + + path(MESH:"Colorectal Neoplasms") positiveCorrelation g(HGNC:GLRX2) + + + + + + + pubmed:22020111 + + path(MESH:"Colorectal Neoplasms") increases g(HGNC:MICB) + + + + + + + pubmed:22020111 + + path(MESH:"Colorectal Neoplasms") increases g(HGNC:NQO1) + + + + + + + pubmed:22020111 + + path(MESH:"Colorectal Neoplasms") positiveCorrelation g(HGNC:NQO1) + + + + + + + pubmed:22020111 + + path(MESH:"Colorectal Neoplasms") positiveCorrelation bp(MESH:"Oxidative Stress") + + + + + + + pubmed:22020111 + + g(HGNC:GLRX2) positiveCorrelation path(MESH:"Colorectal Neoplasms") + + + + + + + pubmed:22020111 + + g(HGNC:NQO1) positiveCorrelation path(MESH:"Colorectal Neoplasms") + + + + + + + pubmed:22020111 + + g(HGNC:NQO1) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:22020111 + + g(HGNC:GLRX) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:22020111 + + g(HGNC:SOD1) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:27181519 + + g(HGNC:SOD1) association path(DOID:"amyotrophic lateral sclerosis") + + + + + + + pubmed:22020111 + + path(MESH:"Kidney Diseases") negativeCorrelation act(p(HGNC:NFE2L2)) + + + + + + + pubmed:30740335 + + path(MESH:"Kidney Diseases") association path(MESH:"Endoplasmic Reticulum Stress") + + + + + + + pubmed:30688256 + + a(MESH:"Autophagy-Related Proteins", loc(GO:"phagophore assembly site")) increases a(GO:phagophore) + + + + + + + pubmed:21722302 + + a(GO:phagophore) increases a(MESH:Autophagosomes) + + + + + + + pubmed:18930136 + + a(GO:phagophore) increases a(GO:autophagosome) + + + + + + + + + pubmed:30688256 + + p(MGI:Atg5) decreases path(HP:Neurodegeneration) + + + + + + + pubmed:25784053 + + p(MGI:Atg5) decreases path(HP:Neurodegeneration) + + + + + + + pubmed:30688256 + + p(MGI:Atg7) decreases path(HP:Neurodegeneration) + + + + + + + pubmed:25784053 + + p(MGI:Atg7) decreases path(HP:Neurodegeneration) + + + + + + + pubmed:24027553 + + p(MGI:Atg7) decreases path(CONSO:Neurodegeneration) + + + + + + + pubmed:24027553 + + p(MGI:Atg7) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:24027553 + + p(MGI:Atg7) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 214), pmod(go:0006468 ! "protein phosphorylation", Thr, 212)) + + + + + + + pubmed:24027553 + + p(MGI:Atg7) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) + + + + + + + pubmed:24027553 + + p(MGI:Atg7) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) + + + + + + + pubmed:30688256 + + p(HGNC:BNIP3L) positiveCorrelation bp(GO:"erythrocyte maturation") + + + + + + + + + + + pubmed:30688256 + + bp(GO:"erythrocyte maturation") positiveCorrelation p(HGNC:BNIP3L) + + + + + + + pubmed:30688256 + + complex(p(HGNC:BNIP3L), p(HGNC:GABARAPL2)) increases a(GO:phagophore) + + + + + + + + + + + + + + + pubmed:18930136 + + p(HGNC:GABARAPL2) increases complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:GABARAPL2)) + + + + + + + pubmed:30688256 + + complex(p(HGNC:BNIP3L), p(HGNC:MAP1LC3B)) increases a(GO:phagophore) + + + + + + + + + + + pubmed:18930136 + + p(HGNC:MAP1LC3B) increases complex(a(GO:autophagosome), p(HGNC:MAP1LC3B)) + + + + + + + + + pubmed:18930136 + + p(HGNC:MAP1LC3B) increases complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:MAP1LC3B)) + + + + + + + + + pubmed:27260836 + + p(HGNC:MAP1LC3B) negativeCorrelation p(HGNC:PICALM) + + + + + + + pubmed:30688256 + + path(HBP:"mitochondrial dysfunction") increases bp(GO:"cell death") + + + + + + + pubmed:30688256 + + path(HBP:"mitochondrial dysfunction") increases bp(GO:"calcium-mediated signaling") + + + + + + + pubmed:30688256 + + path(HBP:"mitochondrial dysfunction") increases a(CHEBI:"reactive oxygen species") + + + + + + + pubmed:30688256 + + path(HBP:"mitochondrial dysfunction") increases path(MESH:Apoptosis) + + + + + + + pubmed:30688256 + + complex(p(HGNC:PMPCA), p(HGNC:PMPCB)) directlyIncreases deg(p(HGNC:PINK1)) + + + + + + + + + + + pubmed:30688256 + + p(HGNCGENEFAMILY:"Miro like atypical Rho GTPases") increases bp(GO:"axonal transport of mitochondrion") + + + + + + + pubmed:30688256 + + p(HGNCGENEFAMILY:"Miro like atypical Rho GTPases") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) + + + + + + + pubmed:30688256 + + p(HGNCGENEFAMILY:"Miro like atypical Rho GTPases") decreases act(p(HGNC:MARK1)) + + + + + + + pubmed:30688256 + + p(HGNCGENEFAMILY:"Miro like atypical Rho GTPases") decreases path(HP:Neurodegeneration) + + + + + + + pubmed:30688256 + + act(p(HGNCGENEFAMILY:"Miro like atypical Rho GTPases")) negativeCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:30688256 + + p(HGNC:PINK1, var("?")) increases path(MESH:"Parkinson Disease") + + + + + + + pubmed:30116051 + + p(HGNC:PINK1, var("?")) association path(MESH:"Parkinson Disease") + + + + + + + pubmed:30688256 + + p(HGNC:PINK1, var("?")) decreases bp(GO:mitophagy) + + + + + + + pubmed:30116051 + + p(HGNC:PINK1, var("?")) decreases bp(GO:mitophagy) + + + + + + + pubmed:30688256 + + p(HGNC:PINK1, var("?")) increases path(HBP:"mitochondrial dysfunction") + + + + + + + pubmed:21722302 + + p(HGNC:PINK1, var("?")) increases path(DOID:"autosomal recessive Parkinson's disease 14") + + + + + + + pubmed:21722302 + + p(HGNC:PINK1, var("?")) association bp(MESH:"Protein Stability") + + + + + + + pubmed:30688256 + + p(HGNC:DNM1L, var("?")) increases path(HP:Neurodegeneration) + + + + + + + pubmed:30688256 + + p(HGNC:CCND1) decreases a(HBP:"amyloid-beta aggregates", loc(MESH:"Extracellular Space")) + + + + + + + pubmed:30688256 + + p(HGNC:CCND1) decreases path(HP:Neurodegeneration) + + + + + + + pubmed:30688256 + + a(CHEBI:FAD) association bp(GO:autophagy) + + + + + + + pubmed:30688256 + + complex(p(HGNC:LRRK2), p(HGNC:RHOT1)) increases deg(p(HGNC:RHOT1)) + + + + + + + + + pubmed:30688256 + + p(HGNC:RHOT1) negativeCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:30688256 + + deg(p(HGNC:RHOT1)) decreases bp(GO:"axonal transport of mitochondrion") + + + + + + + pubmed:30688256 + + p(HGNC:RHOT1) decreases path(HP:Neurodegeneration) + + + + + + + pubmed:30688256 + + a(HBP:"alpha-synuclein aggregates") increases a(CHEBI:"reactive oxygen species") + + + + + + + pubmed:30688256 + + a(HBP:"huntingtin aggregates") increases bp(GO:autophagy) + + + + + + + pubmed:30688256 + + a(HBP:"huntingtin aggregates") increases p(HGNC:ATG7, var("?")) + + + + + + + pubmed:30688256 + + p(HGNC:ATG7, var("?")) increases path(MESH:"Huntington Disease") + + + + + + + + + pubmed:29758300 + + p(HGNC:ATG7) increases bp(GO:macroautophagy) + + + + + + + + + + + pubmed:18930136 + + p(HGNC:ATG7) decreases path(CONSO:Neurodegeneration) + + + + + + + + + + + pubmed:30688256 + + a(PUBCHEM:124886) negativeCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:30688256 + + a(PUBCHEM:124886) increases act(a(MESH:Neurons)) + + + + + + + pubmed:30688256 + + a(PUBCHEM:124886) decreases path(MESH:"Mitochondrial Diseases") + + + + + + + pubmed:30688256 + + bp(GO:"cell redox homeostasis") decreases path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:30740335 + + bp(GO:"cell redox homeostasis") decreases path(MESH:"Protein Unfolding") + + + + + + + pubmed:31413141 + + p(HGNC:TREM2, frag("?")) positiveCorrelation bp(GO:aging) + + + + + + + pubmed:31413141 + + p(HGNC:TREM2, frag("?")) positiveCorrelation p(HGNC:MAPT) + + + + + + + pubmed:31413141 + + p(HGNC:TREM2, frag("?")) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:31413141 + + p(HGNC:TREM2, frag("?")) causesNoChange a(CHEBI:"amyloid-beta polypeptide 42") + + + + + + + pubmed:31413141 + + p(HGNC:TREM2, frag("?")) positiveCorrelation r(DBSNP:rs1582763) + + + + + + + pubmed:31413141 + + p(HGNC:TREM2, frag("?")) association r(DBSNP:rs1582763) + + + + + + + pubmed:31413141 + + p(HGNC:TREM2, frag("?")) association r(DBSNP:rs6591561) + + + + + + + pubmed:31413141 + + p(HGNC:TREM2, var("p.Lys211Pro")) decreases p(HGNC:TREM2, frag("?")) + + + + + + + pubmed:31413141 + + p(HGNC:TREM2, var("p.Asp87Asn")) decreases p(HGNC:TREM2, frag("?")) + + + + + + + pubmed:31413141 + + r(DBSNP:rs1582763) positiveCorrelation p(HGNC:TREM2, frag("?")) + + + + + + + pubmed:31413141 + + r(DBSNP:rs1582763) association p(HGNC:TREM2, frag("?")) + + + + + + + pubmed:31413141 + + r(DBSNP:rs1582763) decreases p(HGNC:MS4A6A) + + + + + + + pubmed:31413141 + + r(DBSNP:rs1582763) decreases p(HGNC:MS4A4A) + + + + + + + pubmed:31413141 + + r(DBSNP:rs1582763) increases p(HGNC:MS4A2) + + + + + + + pubmed:31413141 + + r(DBSNP:rs6591561) association p(HGNC:TREM2, frag("?")) + + + + + + + pubmed:31413141 + + r(DBSNP:rs769449) association p(HGNC:APOE) + + + + + + + pubmed:31413141 + + r(DBSNP:rs769449) causesNoChange p(HGNC:TREM2, frag("?")) + + + + + + + + + pubmed:31413141 + + p(HGNC:MS4A4A, loc(GO:"plasma membrane")) association bp(GO:"protein transport") + + + + + + + pubmed:31413141 + + p(HGNC:MS4A4A, loc(GO:cytoplasm)) association bp(GO:"protein transport") + + + + + + + pubmed:31413141 + + r(HGNC:MS4A6A) positiveCorrelation r(HGNC:TREM2) + + + + + + + pubmed:31413141 + + r(HGNC:TREM2) positiveCorrelation r(HGNC:MS4A6A) + + + + + + + pubmed:31413141 + + r(HGNC:TREM2) positiveCorrelation r(HGNC:MS4A4A) + + + + + + + pubmed:31413141 + + r(HGNC:TREM2) positiveCorrelation r(HGNC:MS4A7) + + + + + + + pubmed:31413141 + + r(HGNC:MS4A4A) positiveCorrelation r(HGNC:TREM2) + + + + + + + pubmed:31413141 + + r(HGNC:MS4A7) positiveCorrelation r(HGNC:TREM2) + + + + + + + pubmed:31413141 + + complex(complex(GO:"immunoglobulin complex"), p(HGNC:MS4A4A)) decreases p(HGNC:TREM2, frag("?"), loc(MESH:Macrophages)) + + + + + + + pubmed:23454242 + + bp(GO:phosphorylation) regulates bp(GO:"cell division") + + + + + + + pubmed:23454242 + + bp(GO:phosphorylation) regulates bp(GO:"cell growth") + + + + + + + pubmed:23454242 + + bp(GO:phosphorylation) regulates bp(GO:"cell development") + + + + + + + pubmed:23454242 + + bp(GO:phosphorylation) increases bp(GO:"negative regulation of apoptotic process") + + + + + + + pubmed:23454242 + + bp(GO:phosphorylation) regulates bp(GO:"cell population proliferation") + + + + + + + pubmed:23454242 + + bp(GO:phosphorylation) regulates bp(GO:"apoptotic process") + + + + + + + pubmed:21882945 + + bp(GO:phosphorylation) regulates a(CONSO:"Hsp27 oligomers") + + + + + + + pubmed:25784053 + + bp(GO:"cell division") association p(FPLX:"CCT_complex") + + + + + + + pubmed:18305152 + + bp(GO:"cell division") increases bp(GO:"cell cycle G1/S phase transition") + + + + + + + pubmed:23454242 + + p(FPLX:PPP2) regulates bp(GO:"glycolytic process") + + + + + + + pubmed:23454242 + + p(FPLX:PPP2) regulates bp(GO:"lipid metabolic process") + + + + + + + pubmed:23454242 + + p(FPLX:PPP2) regulates bp(GO:"catecholamine biosynthetic process") + + + + + + + pubmed:23454242 + + p(FPLX:PPP2) regulates bp(GO:"cell cycle") + + + + + + + pubmed:23454242 + + p(FPLX:PPP2) regulates bp(GO:"DNA replication") + + + + + + + pubmed:23454242 + + p(FPLX:PPP2) regulates bp(GO:"transcription, DNA-templated") + + + + + + + pubmed:23454242 + + p(FPLX:PPP2) regulates bp(GO:translation) + + + + + + + pubmed:23454242 + + p(FPLX:PPP2) regulates bp(GO:"signal transduction") + + + + + + + pubmed:23454242 + + p(FPLX:PPP2) regulates bp(GO:"cell population proliferation") + + + + + + + pubmed:23454242 + + p(FPLX:PPP2) regulates bp(GO:"cell population proliferation") + + + + + + + pubmed:23454242 + + p(FPLX:PPP2) regulates bp(GO:"cytoskeleton organization") + + + + + + + pubmed:23454242 + + p(FPLX:PPP2) increases bp(GO:"cytoskeleton organization") + + + + + + + pubmed:23454242 + + p(FPLX:PPP2) regulates bp(GO:"cell motility") + + + + + + + pubmed:23454242 + + p(FPLX:PPP2) regulates bp(GO:"apoptotic process") + + + + + + + pubmed:23454242 + + p(FPLX:PPP2) regulates bp(GO:"apoptotic process") + + + + + + + pubmed:23454242 + + p(FPLX:PPP2) association path(MESH:"Cell Transformation, Neoplastic") + + + + + + + pubmed:23454242 + + p(FPLX:PPP2) association path(MESH:Neoplasms) + + + + + + + pubmed:23454242 + + p(FPLX:PPP2) decreases path(MESH:Neoplasms) + + + + + + + pubmed:23454242 + + act(p(FPLX:PPP2)) negativeCorrelation path(MESH:Neoplasms) + + + + + + + pubmed:22299660 + + p(FPLX:PPP2) association path(MESH:Neoplasms) + + + + + + + + + pubmed:23454242 + + p(FPLX:PPP2) decreases p(HGNC:VIM, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:23454242 + + act(p(FPLX:PPP2)) decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:22299660 + + act(p(FPLX:PPP2)) negativeCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) + + + + + + + + + pubmed:23454242 + + act(p(FPLX:PPP2)) association p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) + + + + + + + + + pubmed:23454242 + + act(p(FPLX:PPP2)) association p(FPLX:PPP2, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + + + + + pubmed:23454242 + + p(FPLX:PPP2) regulates p(FPLX:AKT, pmod(go:0006468 ! "protein phosphorylation", Thr, 308)) + + + + + + + pubmed:23454242 + + p(FPLX:PPP2) association bp(GO:"Wnt signaling pathway") + + + + + + + pubmed:23454242 + + p(FPLX:PPP2) decreases p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:23454242 + + p(FPLX:PPP2) increases deg(p(HGNC:CTNNB1)) + + + + + + + pubmed:23454242 + + p(FPLX:PPP2) decreases p(HGNC:BAD, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:23454242 + + p(FPLX:PPP2) decreases p(HGNC:BCL2, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + + + pubmed:12428809 + + p(FPLX:PPP2) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:22299660 + + p(FPLX:PPP2) association a(MESH:Cytosol) + + + + + + + pubmed:22299660 + + p(FPLX:PPP2) association a(MESH:"Cell Nucleus") + + + + + + + pubmed:22299660 + + p(FPLX:PPP2) association a(MESH:Mitochondria) + + + + + + + pubmed:22299660 + + p(FPLX:PPP2) association a(MESH:Cytoskeleton) + + + + + + + pubmed:22299660 + + p(FPLX:PPP2) association a(MESH:"Cell Membrane") + + + + + + + pubmed:22299660 + + p(FPLX:PPP2) association path(MESH:"Frontotemporal Dementia") + + + + + + + pubmed:22299660 + + act(p(FPLX:PPP2)) negativeCorrelation a(CONSO:"paired helical filaments") + + + + + + + pubmed:22299660 + + act(p(FPLX:PPP2)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) + + + + + + + pubmed:22299660 + + act(p(FPLX:PPP2)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 42)) + + + + + + + pubmed:22299660 + + act(p(FPLX:PPP2)) decreases act(p(HGNC:CDK5)) + + + + + + + pubmed:22299660 + + act(p(FPLX:PPP2)) decreases act(p(HGNC:TPK1)) + + + + + + + pubmed:22299660 + + act(p(FPLX:PPP2)) decreases act(p(HGNC:GSK3B)) + + + + + + + pubmed:22299660 + + act(p(FPLX:PPP2)) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:22299660 + + act(p(FPLX:PPP2)) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:22299660 + + p(FPLX:PPP2) negativeCorrelation path(MESH:"Down Syndrome") + + + + + + + + + pubmed:23943618 + + act(p(FPLX:PPP2)) positiveCorrelation complex(p(FPLX:PPP2), p(HGNC:MAPT)) + + + + + + + pubmed:27068745 + + act(p(FPLX:PPP2), ma(go:0016791 ! "phosphatase activity")) positiveCorrelation p(HGNC:UNC5B) + + + + + + + pubmed:27068745 + + act(p(FPLX:PPP2), ma(go:0016791 ! "phosphatase activity")) decreases act(p(HGNC:DAPK1, pmod(go:0006468 ! "protein phosphorylation"))) + + + + + + + pubmed:23454242 + + path(MESH:"Cell Transformation, Neoplastic") association p(FPLX:PPP2) + + + + + + + + + pubmed:22299660 + + p(FPLX:PPP2C) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + + + + + + + + + + + + + + + + + + + + + pubmed:23454242 + + p(HGNC:PPP2CB) association a(MESH:Cytosol) + + + + + + + pubmed:23454242 + + p(HGNC:PPP2CB) association a(MESH:"Cell Nucleus") + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + pubmed:24653673 + + p(HGNC:PPP2CB) association act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + pubmed:24653673 + + p(HGNC:PPP2CB) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:24653673 + + deg(p(HGNC:PPP2CB)) positiveCorrelation p(HGNC:IGBP1, frag("?")) + + + + + + + pubmed:24653673 + + p(HGNC:PPP2CB) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + + + + + + + pubmed:23454242 + + a(MESH:"Cell Membrane") association p(HGNC:PPP2CA) + + + + + + + pubmed:22299660 + + a(MESH:"Cell Membrane") association p(FPLX:PPP2) + + + + + + + + + + + pubmed:23454242 + + a(MESH:Cytosol) association p(HGNC:PPP2CB) + + + + + + + pubmed:23454242 + + a(MESH:Cytosol) association p(HGNC:PPP2R2A) + + + + + + + pubmed:23454242 + + a(MESH:Cytosol) association p(HGNC:PPP2R2B) + + + + + + + pubmed:23454242 + + a(MESH:Cytosol) association p(HGNC:PPP2R5A) + + + + + + + pubmed:23454242 + + a(MESH:Cytosol) association p(HGNC:PPP2R5B) + + + + + + + pubmed:23454242 + + a(MESH:Cytosol) association p(HGNC:PPP2R5E) + + + + + + + pubmed:23454242 + + a(MESH:Cytosol) association p(HGNC:PPP2R5D) + + + + + + + pubmed:22299660 + + a(MESH:Cytosol) association p(FPLX:PPP2) + + + + + + + pubmed:23454242 + + a(MESH:"Cell Nucleus") association p(HGNC:PPP2CB) + + + + + + + pubmed:23454242 + + a(MESH:"Cell Nucleus") association p(HGNC:PPP2R5C) + + + + + + + pubmed:23454242 + + a(MESH:"Cell Nucleus") association p(HGNC:PPP2R5D) + + + + + + + pubmed:22299660 + + a(MESH:"Cell Nucleus") association p(FPLX:PPP2) + + + + + + + + + + + + + + + + + + + + + + + pubmed:19277525 + + p(HGNC:PPP2R1A) association p(INTERPRO:"HEAT repeat") + + + + + + + + + + + pubmed:19277525 + + p(HGNC:PPP2R1A) association p(HGNC:PPP2CA) + + + + + + + pubmed:19277525 + + act(p(HGNC:PPP2R1A)) increases act(p(HGNC:PPP2CA)) + + + + + + + + + + + pubmed:19277525 + + act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) + + + + + + + + + pubmed:19277525 + + act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + + + + + + + + + pubmed:19277525 + + act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A)) + + + + + + + + + pubmed:19277525 + + act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(HGNC:PPP2R3B)) + + + + + + + + + pubmed:19277525 + + act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(HGNC:PPP2R3A)) + + + + + + + + + pubmed:19277525 + + act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(HGNC:STRN3)) + + + + + + + + + pubmed:19277525 + + act(p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2R1A), p(HGNC:STRN)) + + + + + + + + + + + + + + + + + + + + + + + pubmed:19933700 + + p(HGNC:PPP2R1A) association bp(GO:"cell-cell signaling") + + + + + + + pubmed:19933700 + + p(HGNC:PPP2R1A) association path(MESH:Metabolism) + + + + + + + + + + + + + pubmed:23454242 + + p(HGNC:PPP2R2A) association a(MESH:Cytosol) + + + + + + + pubmed:23454242 + + p(HGNC:PPP2R2A) increases bp(GO:cytokinesis) + + + + + + + pubmed:23454242 + + p(HGNC:PPP2R2A) association bp(GO:"cytoskeleton organization") + + + + + + + + + + + pubmed:24653673 + + p(HGNC:PPP2R2A) increases act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + pubmed:24653673 + + p(HGNC:PPP2R2A) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + + + + + + + + + pubmed:24653673 + + p(HGNC:PPP2R2A) increases complex(a(GO:"protein phosphatase type 2A complex"), a(GO:microtubule)) + + + + + + + pubmed:24653673 + + p(HGNC:PPP2R2A) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:22299660 + + p(HGNC:PPP2R2A) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:22299660 + + p(HGNC:PPP2R2A) association a(MESH:Brain) + + + + + + + + + + + pubmed:23454242 + + p(HGNC:PPP2R2C) association a(MESH:Cytoskeleton) + + + + + + + pubmed:23454242 + + p(HGNC:PPP2R2C) increases bp(GO:cytokinesis) + + + + + + + pubmed:23454242 + + p(HGNC:PPP2R2C) association bp(GO:"cytoskeleton organization") + + + + + + + + + + + + + pubmed:19277525 + + p(HGNC:PPP2R3A) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R3A)) + + + + + + + pubmed:19277525 + + p(HGNC:PPP2R3A) directlyIncreases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R3A)) + + + + + + + pubmed:19277525 + + p(HGNC:PPP2R3A) association complex(a(PUBCHEM:5460341), p(INTERPRO:"EF-hand domain")) + + + + + + + + + + + + + pubmed:19277525 + + p(HGNC:PPP2R3B) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R3B)) + + + + + + + pubmed:19277525 + + p(HGNC:PPP2R3B) directlyIncreases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R3B)) + + + + + + + + + + + pubmed:19277525 + + p(HGNC:PTPA) increases act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + pubmed:24653673 + + p(HGNC:PTPA) increases act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + pubmed:19277525 + + p(HGNC:PTPA) decreases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) + + + + + + + pubmed:19277525 + + p(HGNC:PTPA) increases p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation", Leu, 309)) + + + + + + + + + + + pubmed:24653673 + + p(HGNC:PTPA) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:24653673 + + p(HGNC:PTPA) decreases p(FPLX:PPP2, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) + + + + + + + + + pubmed:23454242 + + p(HGNC:PPP2R5A) association a(MESH:Cytosol) + + + + + + + + + + + pubmed:23454242 + + p(HGNC:PPP2R5C) association a(MESH:"Cell Nucleus") + + + + + + + + + pubmed:23454242 + + p(HGNC:PPP2R5D) association a(MESH:Cytosol) + + + + + + + pubmed:23454242 + + p(HGNC:PPP2R5D) association a(MESH:"Cell Nucleus") + + + + + + + + + pubmed:24653673 + + p(HGNC:PPP2R5D) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + + + pubmed:23454242 + + p(HGNC:PPP2R5E) association a(MESH:Cytosol) + + + + + + + pubmed:23454242 + + composite(a(CHEBI:"magnesium(2+)"), a(CHEBI:ATP)) increases act(p(HGNC:PPP2R3A)) + + + + + + + pubmed:24027553 + + composite(a(CHEBI:"magnesium(2+)"), a(CHEBI:ATP)) increases act(p(HGNCGENEFAMILY:Proteasome)) + + + + + + + pubmed:23454242 + + complex(p(FPLX:PPP2), p(HGNC:SGO1)) decreases p(FPLX:Cohesin, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + + + + + pubmed:23454242 + + p(FPLX:Cohesin, pmod(go:0006468 ! "protein phosphorylation")) increases bp(GO:"spindle disassembly") + + + + + + + + + pubmed:23454242 + + p(HGNC:SET) decreases act(p(FPLX:PPP2)) + + + + + + + pubmed:23454242 + + p(HGNC:SET) decreases act(p(FPLX:PPP2)) + + + + + + + pubmed:22299660 + + p(HGNC:SET) decreases act(p(FPLX:PPP2)) + + + + + + + pubmed:24653673 + + p(HGNC:SET) decreases act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + pubmed:24653673 + + p(HGNC:SET) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + pubmed:24653673 + + p(HGNC:SET) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + + + pubmed:24653673 + + p(HGNC:SET) increases complex(p(HGNC:PPP2CA), p(HGNC:SET)) + + + + + + + + + pubmed:24653673 + + p(HGNC:SET) increases complex(p(HGNC:PPP2CB), p(HGNC:SET)) + + + + + + + pubmed:24653673 + + p(HGNC:SET) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:22299660 + + p(HGNC:SET) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + + + pubmed:23454242 + + a(PUBCHEM:5311365) decreases act(p(FPLX:PPP2)) + + + + + + + pubmed:24653673 + + a(PUBCHEM:5311365) decreases act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + + + pubmed:24653673 + + a(PUBCHEM:5311365) increases complex(a(PUBCHEM:5311365), p(HGNC:PPP2CA)) + + + + + + + + + pubmed:24653673 + + a(PUBCHEM:5311365) increases complex(a(PUBCHEM:5311365), p(HGNC:PPP2CB)) + + + + + + + pubmed:23454242 + + a(CHEBI:microcystin) decreases act(p(FPLX:PPP2)) + + + + + + + pubmed:23454242 + + a(CHEBI:cantharidin) decreases act(p(FPLX:PPP2)) + + + + + + + pubmed:23454242 + + a(PUBCHEM:4162) decreases act(p(FPLX:PPP2)) + + + + + + + pubmed:23454242 + + a(PUBCHEM:6913994) decreases act(p(FPLX:PPP2)) + + + + + + + pubmed:24653673 + + a(PUBCHEM:6913994) decreases act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + + + pubmed:24653673 + + a(PUBCHEM:6913994) increases complex(a(PUBCHEM:6913994), p(HGNC:PPP2CA)) + + + + + + + + + pubmed:24653673 + + a(PUBCHEM:6913994) increases complex(a(PUBCHEM:6913994), p(HGNC:PPP2CB)) + + + + + + + pubmed:23454242 + + a(CHEBI:Tautomycin) decreases act(p(FPLX:PPP2)) + + + + + + + pubmed:23454242 + + a(PUBCHEM:71361092) increases path(MESH:Neoplasms) + + + + + + + pubmed:23454242 + + a(PUBCHEM:71361092) decreases act(p(FPLX:PPP2)) + + + + + + + + + pubmed:23454242 + + p(HGNC:CIP2A) increases composite(p(HGNC:CIP2A), p(HGNC:MYC)) + + + + + + + pubmed:23454242 + + p(HGNC:CIP2A) decreases act(p(FPLX:PPP2C)) + + + + + + + pubmed:23454242 + + composite(p(HGNC:CIP2A), p(HGNC:MYC)) decreases deg(p(HGNC:MYC)) + + + + + + + pubmed:23454242 + + a(CHEBI:bortezomib) decreases p(HGNC:CIP2A) + + + + + + + pubmed:23454242 + + a(CHEBI:bortezomib) decreases r(HGNC:CIP2A) + + + + + + + pubmed:23454242 + + a(CHEBI:bortezomib) increases act(p(FPLX:PPP2C)) + + + + + + + pubmed:23454242 + + p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) association act(p(FPLX:PPP2)) + + + + + + + pubmed:19277525 + + p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) regulates bp(GO:"cell cycle") + + + + + + + pubmed:24653673 + + p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) positiveCorrelation complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) + + + + + + + pubmed:24653673 + + p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) association complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) + + + + + + + pubmed:24653673 + + p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) positiveCorrelation complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) + + + + + + + pubmed:24653673 + + p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) association complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) + + + + + + + pubmed:24653673 + + p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:24653673 + + p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:24653673 + + p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:24653673 + + p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) association bp(GO:"one-carbon metabolic process") + + + + + + + pubmed:24653673 + + p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) negativeCorrelation a(CHEBI:homocysteine) + + + + + + + pubmed:24653673 + + p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) negativeCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:24653673 + + p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) negativeCorrelation p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:24653673 + + p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) regulates bp(CONSO:"APP processing") + + + + + + + pubmed:24653673 + + p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) regulates bp(MESH:"Neuronal Outgrowth") + + + + + + + pubmed:24653673 + + p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) regulates p(HGNC:MAPT) + + + + + + + pubmed:23454242 + + p(FPLX:PPP2, pmod(go:0006468 ! "protein phosphorylation")) association act(p(FPLX:PPP2)) + + + + + + + pubmed:23454242 + + p(FPLX:PPP2, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) decreases act(p(FPLX:PPP2)) + + + + + + + pubmed:23454242 + + p(FPLX:PPP2, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) decreases complex(p(HGNC:PPP2R2A), p(HGNC:PPP2R5B)) + + + + + + + pubmed:24653673 + + p(FPLX:PPP2, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + pubmed:24653673 + + p(FPLX:PPP2, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + pubmed:23454242 + + p(HGNC:LCMT1) increases p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation", Leu, 309)) + + + + + + + pubmed:19277525 + + p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation", Leu, 309)) + + + + + + + pubmed:19277525 + + p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation", Leu, 309)) + + + + + + + pubmed:24653673 + + p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation", Leu, 309)) + + + + + + + pubmed:24653673 + + p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation", Leu, 309)) + + + + + + + pubmed:24653673 + + p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation", Leu, 309)) + + + + + + + pubmed:24653673 + + p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation", Leu, 309)) + + + + + + + pubmed:23943618 + + p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation", Leu, 309)) + + + + + + + pubmed:29281045 + + p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation", Leu, 309)) + + + + + + + pubmed:19277525 + + act(p(HGNC:LCMT1)) negativeCorrelation act(p(HGNC:PPME1)) + + + + + + + pubmed:19277525 + + p(HGNC:LCMT1) causesNoChange act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + pubmed:24653673 + + p(HGNC:LCMT1) increases p(HGNC:PPP2CB, pmod(go:0006479 ! "protein methylation", Leu, 309)) + + + + + + + pubmed:24653673 + + p(HGNC:LCMT1) increases p(HGNC:PPP2CB, pmod(go:0006479 ! "protein methylation", Leu, 309)) + + + + + + + pubmed:24653673 + + p(HGNC:LCMT1) increases p(HGNC:PPP2CB, pmod(go:0006479 ! "protein methylation", Leu, 309)) + + + + + + + pubmed:24653673 + + p(HGNC:LCMT1) increases p(HGNC:PPP2CB, pmod(go:0006479 ! "protein methylation", Leu, 309)) + + + + + + + + + + + pubmed:24653673 + + p(HGNC:LCMT1) regulates complex(a(GO:"protein phosphatase type 2A complex"), a(MESH:"Membrane Microdomains")) + + + + + + + pubmed:24653673 + + p(HGNC:LCMT1) increases p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) + + + + + + + pubmed:23454242 + + p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation", Leu, 309)) increases act(p(FPLX:PPP2)) + + + + + + + pubmed:23454242 + + p(FPLX:AKT, pmod(go:0006468 ! "protein phosphorylation", Thr, 308)) increases act(p(FPLX:AKT)) + + + + + + + pubmed:23454242 + + p(HGNC:CTNNB1, pmod(go:0006468 ! "protein phosphorylation")) increases bp(GO:"Wnt signaling pathway") + + + + + + + pubmed:23454242 + + p(HGNC:BAD, pmod(go:0006468 ! "protein phosphorylation")) decreases bp(GO:"apoptotic process") + + + + + + + pubmed:23454242 + + p(HGNC:BCL2, pmod(go:0006468 ! "protein phosphorylation")) decreases bp(GO:"apoptotic process") + + + + + + + pubmed:21722302 + + p(HGNC:BCL2, pmod(go:0006468 ! "protein phosphorylation")) decreases composite(a(MESH:Beclin-1), p(HGNC:BCL2)) + + + + + + + pubmed:23528736 + + p(HGNC:BCL2, pmod(go:0006468 ! "protein phosphorylation")) increases bp(GO:autophagy) + + + + + + + pubmed:19277525 + + complex(GO:"protein phosphatase type 2A complex") regulates bp(GO:"cell cycle") + + + + + + + pubmed:19277525 + + complex(GO:"protein phosphatase type 2A complex") regulates bp(GO:"cell population proliferation") + + + + + + + pubmed:19277525 + + complex(GO:"protein phosphatase type 2A complex") regulates bp(GO:"cell death") + + + + + + + pubmed:19277525 + + complex(GO:"protein phosphatase type 2A complex") regulates act(a(GO:cytoskeleton)) + + + + + + + pubmed:19277525 + + complex(GO:"protein phosphatase type 2A complex") regulates bp(GO:"cell motility") + + + + + + + pubmed:19277525 + + complex(GO:"protein phosphatase type 2A complex") regulates bp(GO:"signal transduction") + + + + + + + pubmed:19277525 + + complex(GO:"protein phosphatase type 2A complex") increases bp(GO:"protein dephosphorylation") + + + + + + + pubmed:19277525 + + complex(GO:"protein phosphatase type 2A complex") decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:19277525 + + act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation composite(p(HGNC:PPME1), p(HGNC:PPP2CA), p(HGNC:PPP2R1A)) + + + + + + + pubmed:24653673 + + complex(GO:"protein phosphatase type 2A complex") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:24653673 + + act(complex(GO:"protein phosphatase type 2A complex")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:24653673 + + act(complex(GO:"protein phosphatase type 2A complex")) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:24653673 + + complex(GO:"protein phosphatase type 2A complex") increases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:GSK3B)) + + + + + + + pubmed:24653673 + + complex(GO:"protein phosphatase type 2A complex") increases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:CDK5)) + + + + + + + pubmed:24653673 + + complex(GO:"protein phosphatase type 2A complex") increases complex(a(GO:"protein phosphatase type 2A complex"), a(MESH:"Receptors, N-Methyl-D-Aspartate")) + + + + + + + pubmed:24653673 + + complex(GO:"protein phosphatase type 2A complex") increases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:GRM5)) + + + + + + + pubmed:24653673 + + act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation p(HGNC:PPME1) + + + + + + + pubmed:24653673 + + act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:24653673 + + complex(GO:"protein phosphatase type 2A complex") positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:24653673 + + act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:24653673 + + act(complex(GO:"protein phosphatase type 2A complex")) association p(HGNC:PPP2CA) + + + + + + + pubmed:24653673 + + act(complex(GO:"protein phosphatase type 2A complex")) association p(HGNC:PPP2CB) + + + + + + + pubmed:24653673 + + act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation p(HGNC:ANP32A) + + + + + + + pubmed:24653673 + + act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation p(HGNC:SET) + + + + + + + pubmed:24653673 + + act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation p(HGNC:SET) + + + + + + + pubmed:24653673 + + act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation p(HGNC:SET, frag("?")) + + + + + + + pubmed:24653673 + + act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation p(FPLX:PPP2, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) + + + + + + + pubmed:24653673 + + act(complex(GO:"protein phosphatase type 2A complex")) decreases bp(GO:"neuron death") + + + + + + + pubmed:24653673 + + act(complex(GO:"protein phosphatase type 2A complex")) increases act(p(HGNC:GSK3B)) + + + + + + + pubmed:24653673 + + act(complex(GO:"protein phosphatase type 2A complex")) increases act(p(HGNC:CDK5)) + + + + + + + pubmed:24653673 + + act(complex(GO:"protein phosphatase type 2A complex")) increases act(p(FPLX:ERK)) + + + + + + + pubmed:24653673 + + act(complex(GO:"protein phosphatase type 2A complex")) increases act(p(FPLX:JNK)) + + + + + + + + + pubmed:10464280 + + act(complex(GO:"protein phosphatase type 2A complex")) increases complex(complex(GO:"protein phosphatase type 2A complex"), p(CONSO:"microtubule-binding region")) + + + + + + + pubmed:10464280 + + act(complex(GO:"protein phosphatase type 2A complex")) increases rxn(reactants(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT))) + + + + + + + + + pubmed:19277525 + + p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + + + + + + + pubmed:19277525 + + p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") directlyIncreases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + + + + + + + pubmed:19277525 + + p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + + + + + + + pubmed:19277525 + + p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") association p(INTERPRO:"WD40 repeat") + + + + + + + pubmed:19277525 + + p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases bp(GO:"protein dephosphorylation") + + + + + + + + + pubmed:19277525 + + p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases complex(p(HGNC:PPP2CA), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + + + + + + + + + pubmed:19277525 + + p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") increases complex(p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + + + + + + + pubmed:19277525 + + p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) + + + + + + + + + pubmed:19277525 + + complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + + + pubmed:19277525 + + p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) + + + + + + + pubmed:19277525 + + p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") directlyIncreases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) + + + + + + + + + pubmed:19277525 + + p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") association p(INTERPRO:"HEAT repeat") + + + + + + + + + pubmed:19277525 + + p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") regulates complex(p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) + + + + + + + + + pubmed:19277525 + + p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") causesNoChange complex(p(HGNC:PPP2CA), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) + + + + + + + pubmed:19277525 + + p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") increases complex(p(HGNC:PPP2CA), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) + + + + + + + pubmed:24653673 + + p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") increases tloc(complex(GO:"protein phosphatase type 2A complex"), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) + + + + + + + pubmed:24653673 + + p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") increases tloc(complex(GO:"protein phosphatase type 2A complex"), fromLoc(GO:cytoplasm), toLoc(GO:centrosome)) + + + + + + + pubmed:19277525 + + complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:SGO1), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) + + + + + + + pubmed:19277525 + + complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + + + pubmed:19277525 + + p(HGNC:STRN3) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:STRN3)) + + + + + + + + + + + pubmed:19277525 + + p(HGNC:STRN) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:STRN)) + + + + + + + + + pubmed:19277525 + + p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation", Leu, 309)) decreases complex(p(HGNC:IGBP1), p(HGNC:PPP2CA)) + + + + + + + pubmed:19277525 + + p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation", Leu, 309)) increases act(p(HGNC:PPP2CA)) + + + + + + + pubmed:24653673 + + p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation", Leu, 309)) increases complex(GO:"protein phosphatase type 2A complex") + + + + + + + pubmed:24653673 + + p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation", Leu, 309)) increases act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + pubmed:24653673 + + p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation", Leu, 309)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2CB), p(HGNC:PPP2R2A)) + + + + + + + pubmed:23943618 + + p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation", Leu, 309)) increases act(p(FPLX:PPP2)) + + + + + + + pubmed:19277525 + + complex(p(HGNC:IGBP1), p(HGNC:PPP2CA)) decreases bp(GO:"cell death") + + + + + + + pubmed:24653673 + + complex(p(HGNC:IGBP1), p(HGNC:PPP2CA)) regulates complex(GO:"protein phosphatase type 2A complex") + + + + + + + + + + + + + pubmed:19277525 + + p(HGNC:PPME1) decreases p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation", Leu, 309)) + + + + + + + pubmed:19277525 + + p(HGNC:PPME1) decreases p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation", Leu, 309)) + + + + + + + pubmed:19277525 + + p(HGNC:PPME1) decreases p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation", Leu, 309)) + + + + + + + pubmed:24653673 + + act(p(HGNC:PPME1)) decreases p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation", Leu, 309)) + + + + + + + pubmed:29281045 + + p(HGNC:PPME1) decreases p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation", Leu, 309)) + + + + + + + pubmed:19277525 + + act(p(HGNC:PPME1)) negativeCorrelation act(p(HGNC:LCMT1)) + + + + + + + + + pubmed:19277525 + + p(HGNC:PPME1) increases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) + + + + + + + pubmed:19277525 + + p(HGNC:PPME1) directlyIncreases complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) + + + + + + + pubmed:19277525 + + p(HGNC:PPME1) decreases act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + pubmed:24653673 + + p(HGNC:PPME1) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + + + + + pubmed:24653673 + + p(HGNC:PPME1) increases complex(p(HGNC:PPME1), p(HGNC:PPP2CA)) + + + + + + + + + pubmed:24653673 + + p(HGNC:PPME1) increases complex(p(HGNC:PPME1), p(HGNC:PPP2CB)) + + + + + + + pubmed:22299660 + + p(HGNC:PPME1) decreases p(FPLX:PPP2C, pmod(go:0006479 ! "protein methylation")) + + + + + + + pubmed:19277525 + + p(INTERPRO:"HEAT repeat") association p(HGNC:PPP2R1A) + + + + + + + + + + + + + + + pubmed:19277525 + + p(INTERPRO:"HEAT repeat") association p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56") + + + + + + + pubmed:30027901 + + p(INTERPRO:"HEAT repeat") regulates a(MESH:"Nucleocytoplasmic Transport Proteins") + + + + + + + pubmed:30027901 + + p(INTERPRO:"HEAT repeat") regulates a(GO:"cytoplasmic microtubule") + + + + + + + pubmed:30027901 + + p(INTERPRO:"HEAT repeat") regulates bp(GO:"chromosome segregation") + + + + + + + + + pubmed:19277525 + + p(UNIPROT:P03081) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(UNIPROT:P03081)) + + + + + + + pubmed:19277525 + + p(UNIPROT:P03081) causesNoChange complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) + + + + + + + pubmed:19277525 + + p(UNIPROT:P03081) causesNoChange complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R3B)) + + + + + + + pubmed:19277525 + + p(UNIPROT:P03081) causesNoChange complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R3A)) + + + + + + + pubmed:19277525 + + p(UNIPROT:P03081) causesNoChange complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:STRN3)) + + + + + + + pubmed:19277525 + + p(UNIPROT:P03081) causesNoChange complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:STRN)) + + + + + + + pubmed:19277525 + + complex(p(HGNC:PPP2CA), p(INTERPRO:"HEAT repeat")) association p(HGNC:PPP2CA) + + + + + + + pubmed:19277525 + + complex(p(HGNC:PPP2CA), p(INTERPRO:"HEAT repeat")) association complex(p(HGNC:PPP2R1A), p(INTERPRO:"HEAT repeat")) + + + + + + + pubmed:19277525 + + complex(p(HGNC:PPP2R1A), p(INTERPRO:"HEAT repeat")) association complex(p(HGNC:PPP2CA), p(INTERPRO:"HEAT repeat")) + + + + + + + pubmed:19277525 + + p(INTERPRO:"HEAT repeat", var("p.Arg418Trp")) decreases complex(p(HGNC:PPP2CA), p(INTERPRO:"HEAT repeat")) + + + + + + + pubmed:19277525 + + p(INTERPRO:"HEAT repeat", var("p.Val545Ala")) decreases complex(p(HGNC:PPP2CA), p(INTERPRO:"HEAT repeat")) + + + + + + + pubmed:19277525 + + a(CHEBI:microcystin-LR) decreases act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + pubmed:19277525 + + a(CHEBI:microcystin-LR) increases path(MESH:Neoplasms) + + + + + + + pubmed:19277525 + + a(CHEBI:microcystin-LR) decreases act(p(HGNC:PPME1)) + + + + + + + pubmed:29228318 + + a(CHEBI:microcystin-LR) decreases p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation")) + + + + + + + pubmed:19277525 + + complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:SGO1), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) increases bp(GO:"cell cycle") + + + + + + + pubmed:19277525 + + p(INTERPRO:"WD40 repeat") association p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55") + + + + + + + pubmed:19277525 + + complex(a(PUBCHEM:5460341), p(INTERPRO:"EF-hand domain")) association p(HGNC:PPP2R3A) + + + + + + + + + + + pubmed:19277525 + + complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:19277525 + + complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + + + + + + + pubmed:19277525 + + p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation")) increases complex(GO:"protein phosphatase type 2A complex") + + + + + + + pubmed:24653673 + + p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation")) increases act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + pubmed:19277525 + + p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation")) causesNoChange complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + + + + + + + pubmed:19277525 + + p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation")) causesNoChange complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) + + + + + + + + + pubmed:29228318 + + p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation")) decreases act(p(HGNC:PPP2CA)) + + + + + + + pubmed:29228318 + + p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation")) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2CB)) + + + + + + + pubmed:19277525 + + p(HGNC:PPP2CA, var("?")) causesNoChange complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + + + + + + + pubmed:19277525 + + p(HGNC:PPP2CA, var("?")) causesNoChange complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) + + + + + + + pubmed:19277525 + + p(HGNC:PPP2CA, var("p.Arg295_Leu309del")) causesNoChange complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + + + + + + + pubmed:19277525 + + p(HGNC:PPP2CA, var("p.Arg295_Leu309del")) causesNoChange complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A, regulatory B subunit, B56")) + + + + + + + pubmed:19277525 + + complex(p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation")), p(HGNC:PPP2R1A)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(INTERPRO:"Protein phosphatase 2A regulatory subunit PR55")) + + + + + + + pubmed:19277525 + + complex(p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation")), p(HGNC:PPP2R1A)) increases complex(GO:"protein phosphatase type 2A complex") + + + + + + + pubmed:19277525 + + complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) decreases act(p(HGNC:PPP2CA)) + + + + + + + pubmed:19277525 + + complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) decreases act(p(HGNC:PPP2CA)) + + + + + + + pubmed:19277525 + + complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) increases act(p(HGNC:PPME1)) + + + + + + + pubmed:19277525 + + complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) increases act(p(HGNC:PPME1)) + + + + + + + pubmed:19277525 + + complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) increases act(p(HGNC:PPME1)) + + + + + + + pubmed:19277525 + + complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) decreases p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation", Leu, 309)) + + + + + + + pubmed:19277525 + + complex(a(GO:"protein phosphatase type 2A complex"), p(HGNC:PPME1)) decreases p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation", Leu, 309)) + + + + + + + + + + + + + + + + + + + + + + + pubmed:19277525 + + composite(p(HGNC:PPME1), p(HGNC:PPP2CA), p(HGNC:PPP2R1A)) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + pubmed:24653673 + + p(HGNC:PPP2CB, pmod(go:0006479 ! "protein methylation", Leu, 309)) increases complex(GO:"protein phosphatase type 2A complex") + + + + + + + pubmed:24653673 + + p(HGNC:PPP2CB, pmod(go:0006479 ! "protein methylation", Leu, 309)) increases act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + pubmed:24653673 + + p(HGNC:PPP2CB, pmod(go:0006479 ! "protein methylation", Leu, 309)) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2CB), p(HGNC:PPP2R2A)) + + + + + + + pubmed:24653673 + + a(CHEBI:S-adenosyl-L-methionine) increases act(p(HGNC:LCMT1)) + + + + + + + pubmed:24653673 + + a(CHEBI:S-adenosyl-L-homocysteine) decreases act(p(HGNC:LCMT1)) + + + + + + + pubmed:24653673 + + complex(p(HGNC:PPME1), p(HGNC:PPP2CA)) decreases p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation")) + + + + + + + pubmed:24653673 + + complex(p(HGNC:PPME1), p(HGNC:PPP2CA)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + pubmed:24653673 + + complex(p(HGNC:PPME1), p(HGNC:PPP2CA)) regulates complex(GO:"protein phosphatase type 2A complex") + + + + + + + pubmed:24653673 + + complex(p(HGNC:PPME1), p(HGNC:PPP2CB)) decreases p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation")) + + + + + + + pubmed:24653673 + + complex(p(HGNC:PPME1), p(HGNC:PPP2CB)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + pubmed:24653673 + + complex(p(HGNC:PPME1), p(HGNC:PPP2CB)) regulates complex(GO:"protein phosphatase type 2A complex") + + + + + + + pubmed:24653673 + + p(HGNC:PPP2CB, pmod(go:0006479 ! "protein methylation")) increases act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + pubmed:24653673 + + p(HGNC:PPP2CA, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + pubmed:24653673 + + p(HGNC:PPP2CA, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + pubmed:24653673 + + p(HGNC:PPP2CA, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:24653673 + + p(HGNC:PPP2CB, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + pubmed:24653673 + + p(HGNC:PPP2CB, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + pubmed:24653673 + + p(HGNC:PPP2CB, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:24653673 + + p(HGNC:PPP2CA, pmod(go:0016567 ! "protein ubiquitination")) increases deg(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + pubmed:24653673 + + p(HGNC:PPP2CA, pmod(CONSO:nitration, Tyr)) increases act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + pubmed:24653673 + + p(HGNC:PPP2R5A, pmod(go:0006468 ! "protein phosphorylation", Ser)) regulates act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + pubmed:24653673 + + p(HGNC:PPP2R5D, pmod(go:0006468 ! "protein phosphorylation", Ser)) regulates act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + pubmed:24653673 + + p(HGNC:PPP2R1A, pmod(go:0006468 ! "protein phosphorylation", Ser), pmod(go:0006468 ! "protein phosphorylation", Thr)) decreases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A)) + + + + + + + pubmed:24653673 + + p(HGNC:PPP2R1A, pmod(go:0006468 ! "protein phosphorylation", Ser), pmod(go:0006468 ! "protein phosphorylation", Thr)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + pubmed:24653673 + + p(HGNC:PPP2R1B, pmod(go:0006468 ! "protein phosphorylation", Ser), pmod(go:0006468 ! "protein phosphorylation", Thr)) decreases complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A)) + + + + + + + pubmed:24653673 + + p(HGNC:PPP2R1B, pmod(go:0006468 ! "protein phosphorylation", Ser), pmod(go:0006468 ! "protein phosphorylation", Thr)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + pubmed:24653673 + + complex(a(CHEBI:"okadaic acid"), p(HGNC:PPP2CA)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + pubmed:24653673 + + complex(a(CHEBI:"okadaic acid"), p(HGNC:PPP2CB)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + pubmed:24653673 + + complex(a(PUBCHEM:5311365), p(HGNC:PPP2CA)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + pubmed:24653673 + + complex(a(PUBCHEM:5311365), p(HGNC:PPP2CB)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + pubmed:24653673 + + complex(a(PUBCHEM:6913994), p(HGNC:PPP2CA)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + pubmed:24653673 + + complex(a(PUBCHEM:6913994), p(HGNC:PPP2CB)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + pubmed:24653673 + + complex(p(HGNC:PPP2CA), p(HGNC:SET)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + pubmed:24653673 + + complex(p(HGNC:PPP2CB), p(HGNC:SET)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + pubmed:24653673 + + p(HGNC:ANP32A) decreases act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + pubmed:24653673 + + p(HGNC:ANP32A) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + + + pubmed:24653673 + + p(HGNC:ANP32A) increases complex(p(HGNC:ANP32A), p(HGNC:PPP2CA)) + + + + + + + + + pubmed:24653673 + + p(HGNC:ANP32A) increases complex(p(HGNC:ANP32A), p(HGNC:PPP2CB)) + + + + + + + pubmed:24653673 + + p(HGNC:ANP32A) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:22299660 + + p(HGNC:ANP32A) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:22299660 + + p(HGNC:ANP32A) decreases act(p(FPLX:PPP2)) + + + + + + + pubmed:24653673 + + complex(p(HGNC:ANP32A), p(HGNC:PPP2CA)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + pubmed:24653673 + + complex(p(HGNC:ANP32A), p(HGNC:PPP2CB)) decreases act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + pubmed:24653673 + + a(CHEBI:"metal cation") increases act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + pubmed:24653673 + + a(CHEBI:polyamine) increases act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + pubmed:21882945 + + a(CHEBI:polyamine) decreases act(p(INTERPRO:"Heat shock protein 70 family")) + + + + + + + pubmed:24653673 + + complex(p(HGNC:LCMT1), p(HGNC:PPP2CA)) regulates complex(GO:"protein phosphatase type 2A complex") + + + + + + + pubmed:24653673 + + complex(p(HGNC:LCMT1), p(HGNC:PPP2CB)) regulates complex(GO:"protein phosphatase type 2A complex") + + + + + + + pubmed:24653673 + + complex(p(HGNC:IGBP1), p(HGNC:PPP2CB)) regulates complex(GO:"protein phosphatase type 2A complex") + + + + + + + pubmed:24653673 + + complex(p(HGNC:PPP2CA), p(HGNC:PTPA)) regulates complex(GO:"protein phosphatase type 2A complex") + + + + + + + pubmed:24653673 + + complex(p(HGNC:PPP2CB), p(HGNC:PTPA)) regulates complex(GO:"protein phosphatase type 2A complex") + + + + + + + pubmed:24653673 + + complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) increases complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) + + + + + + + pubmed:24653673 + + complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) increases complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) + + + + + + + pubmed:24653673 + + complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) increases complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) + + + + + + + pubmed:24653673 + + complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) positiveCorrelation p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) + + + + + + + pubmed:24653673 + + complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) association p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) + + + + + + + pubmed:24653673 + + complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) regulates p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) + + + + + + + pubmed:24653673 + + complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) negativeCorrelation path(MESH:Tauopathies) + + + + + + + pubmed:24653673 + + complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:24653673 + + complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:24653673 + + complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) increases complex(a(GO:microtubule), p(HGNC:MAPT)) + + + + + + + pubmed:24653673 + + complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) regulates a(GO:microtubule) + + + + + + + pubmed:24653673 + + complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) regulates bp(MESH:"Neuronal Outgrowth") + + + + + + + pubmed:24653673 + + complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:24653673 + + complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:24653673 + + complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) regulates p(HGNC:MAPT) + + + + + + + pubmed:24653673 + + complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:24653673 + + complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:24653673 + + complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:24653673 + + complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) increases complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) + + + + + + + pubmed:24653673 + + complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) increases complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) + + + + + + + pubmed:24653673 + + complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) increases complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) + + + + + + + pubmed:24653673 + + complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) positiveCorrelation p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) + + + + + + + pubmed:24653673 + + complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) association p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) + + + + + + + pubmed:24653673 + + complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) regulates p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) + + + + + + + pubmed:24653673 + + complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) negativeCorrelation path(MESH:Tauopathies) + + + + + + + pubmed:24653673 + + complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:24653673 + + complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:24653673 + + complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) increases complex(a(GO:microtubule), p(HGNC:MAPT)) + + + + + + + pubmed:24653673 + + complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) regulates a(GO:microtubule) + + + + + + + pubmed:24653673 + + complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) regulates bp(MESH:"Neuronal Outgrowth") + + + + + + + pubmed:24653673 + + complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:24653673 + + complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:24653673 + + complex(p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) regulates p(HGNC:MAPT) + + + + + + + pubmed:24653673 + + complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:24653673 + + complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:24653673 + + complex(p(HGNC:MAPT), p(HGNC:PPP2CB), p(HGNC:PPP2R1A), p(HGNC:PPP2R2A)) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + + + pubmed:24653673 + + g(HGNC:PPP2CA) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:24653673 + + r(HGNC:PPP2CA) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:22299660 + + r(HGNC:PPP2CA) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:24653673 + + g(HGNC:PPP2CB) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:24653673 + + r(HGNC:PPP2CB) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:22299660 + + r(HGNC:PPP2CB) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:24653673 + + r(HGNC:PPP2R2C) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:24653673 + + r(HGNC:PPP2R5E) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:24653673 + + p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation", Tyr, 307)) association a(GO:"neurofibrillary tangle") + + + + + + + pubmed:24653673 + + p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation", Tyr, 307)) association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:24653673 + + p(HGNC:SET, frag("?")) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:24653673 + + p(HGNC:SET, frag("?")) increases path(MESH:"Alzheimer Disease") + + + + + + + pubmed:24653673 + + p(HGNC:SET, frag("?")) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) + + + + + + + pubmed:24653673 + + p(HGNC:IGBP1, frag("?")) regulates complex(GO:"protein phosphatase type 2A complex") + + + + + + + pubmed:24653673 + + p(HGNC:IGBP1, frag("?")) positiveCorrelation deg(p(HGNC:PPP2CA)) + + + + + + + pubmed:24653673 + + p(HGNC:IGBP1, frag("?")) positiveCorrelation deg(p(HGNC:PPP2CB)) + + + + + + + pubmed:24653673 + + p(HGNC:PPP2CA, var("p.Leu309Ala")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:24653673 + + p(HGNC:PPP2CB, var("p.Leu309Ala")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:24653673 + + a(GO:"neurofilament cytoskeleton") negativeCorrelation act(p(HGNC:GSK3B)) + + + + + + + pubmed:24653673 + + a(GO:"neurofilament cytoskeleton") negativeCorrelation act(p(HGNC:CDK5)) + + + + + + + pubmed:24653673 + + a(GO:"neurofilament cytoskeleton") negativeCorrelation act(p(FPLX:ERK)) + + + + + + + pubmed:21722302 + + a(GO:"neurofilament cytoskeleton") association path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:24653673 + + bp(GO:"negative regulation of synaptic plasticity") positiveCorrelation act(p(HGNC:GSK3B)) + + + + + + + pubmed:24653673 + + bp(GO:"negative regulation of synaptic plasticity") positiveCorrelation act(p(HGNC:CDK5)) + + + + + + + pubmed:24653673 + + bp(GO:"negative regulation of synaptic plasticity") positiveCorrelation act(p(FPLX:ERK)) + + + + + + + pubmed:30985105 + + complex(a(GO:microtubule), p(HGNC:MAPT)) increases act(p(HGNC:MAPT)) + + + + + + + pubmed:26631930 + + complex(a(GO:microtubule), p(HGNC:MAPT)) increases bp(GO:"microtubule bundle formation") + + + + + + + pubmed:26631930 + + complex(a(GO:microtubule), p(HGNC:MAPT)) increases bp(GO:"actin cytoskeleton reorganization") + + + + + + + pubmed:26631930 + + complex(a(GO:microtubule), p(HGNC:MAPT)) negativeCorrelation a(CONSO:"Tau aggregates") + + + + + + + pubmed:26631930 + + complex(a(GO:microtubule), p(HGNC:MAPT)) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:24653673 + + bp(GO:"one-carbon metabolic process") association p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) + + + + + + + pubmed:24653673 + + bp(GO:"one-carbon metabolic process") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:24653673 + + bp(GO:"one-carbon metabolic process") decreases bp(CONSO:amyloidogenesis) + + + + + + + pubmed:24653673 + + bp(GO:"one-carbon metabolic process") decreases p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation", Thr, 668)) + + + + + + + pubmed:24653673 + + bp(GO:"one-carbon metabolic process") increases bp(GO:cognition) + + + + + + + pubmed:24653673 + + bp(GO:"one-carbon metabolic process") decreases act(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:24653673 + + a(CHEBI:folates) decreases p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) + + + + + + + pubmed:24653673 + + a(CHEBI:folates) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:24653673 + + a(CHEBI:folates) increases p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:24653673 + + path(MESH:"Vitamin B Deficiency") decreases p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) + + + + + + + pubmed:24653673 + + path(MESH:"Vitamin B Deficiency") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:24653673 + + path(MESH:"Vitamin B Deficiency") increases p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + + + pubmed:12428809 + + p(HGNC:MAPK9) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:12428809 + + p(FPLX:CK2) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:12428809 + + p(FPLX:PPP1) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:21734277 + + act(p(FPLX:PPP1)) decreases bp(GO:"axonal transport") + + + + + + + + + pubmed:21489990 + + act(p(FPLX:PPP1)) decreases p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) + + + + + + + pubmed:12428809 + + p(FPLX:PPP3) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:30988501 + + path(MESH:"Wallerian Degeneration") increases deg(a(MESH:Neurons)) + + + + + + + pubmed:12428809 + + a(MESH:"Intermediate Filaments") positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:12428809 + + a(MESH:"Intermediate Filaments") negativeCorrelation a(MESH:Axons) + + + + + + + pubmed:12428809 + + a(CONSO:"straight filaments") association path(MESH:"Alzheimer Disease") + + + + + + + pubmed:12428809 + + p(HGNC:APPL) increases bp(GO:"anterograde axonal transport") + + + + + + + pubmed:22299660 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 198)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:23088643 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 198)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:22299660 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:26458742 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:23088643 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:20071522 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) isA p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:20071522 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) association complex(p(HGNC:FKBP5), p(HGNC:MAPT)) + + + + + + + pubmed:20071522 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) positiveCorrelation p(HGNC:FKBP5) + + + + + + + pubmed:21367866 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) positiveCorrelation p(HGNC:CDC37) + + + + + + + pubmed:17078951 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) positiveCorrelation p(FPLX:PKA) + + + + + + + pubmed:23088643 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) partOf p(CONSO:"Tau epitope, AT8") + + + + + + + pubmed:25331948 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) partOf p(CONSO:"Tau epitope, AT8") + + + + + + + pubmed:22833681 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) partOf p(CONSO:"Tau epitope, AT8") + + + + + + + pubmed:19459590 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) decreases complex(a(MESH:Microtubules), p(HGNC:MAPT)) + + + + + + + pubmed:22833681 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) increases complex(p(HGNC:FYN), p(HGNC:MAPT)) + + + + + + + pubmed:21734277 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) positiveCorrelation p(CONSO:"phosphatase-activating domain") + + + + + + + pubmed:22299660 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:29191965 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:26751493 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:27373205 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:23088643 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:26751493 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) partOf p(CONSO:"Tau aggregates") + + + + + + + pubmed:27373205 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) association a(CONSO:"Tau oligomers") + + + + + + + pubmed:22817713 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) association a(CONSO:"Tau oligomers") + + + + + + + pubmed:27373205 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) association a(CONSO:"Tau antibody, TNT1") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) decreases p(HGNC:MAPT, frag("1_421")) + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) decreases p(HGNC:MAPT, frag("421_*")) + + + + + + + pubmed:26671985 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) biomarkerFor path(MESH:"Chronic Traumatic Encephalopathy") + + + + + + + pubmed:26671985 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) increases path(MESH:"Cognitive Dysfunction") + + + + + + + pubmed:17078951 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) positiveCorrelation p(FPLX:PKA) + + + + + + + pubmed:23088643 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) partOf a(GO:"neurofibrillary tangle") + + + + + + + pubmed:23088643 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) association a(GO:"neurofibrillary tangle") + + + + + + + pubmed:23088643 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) partOf a(MESH:"Neuropil Threads") + + + + + + + pubmed:23088643 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) partOf path(MESH:"Plaque, Amyloid") + + + + + + + pubmed:23088643 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) association a(CONSO:pretangles) + + + + + + + pubmed:11943212 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) partOf p(CONSO:"Tau epitope, AP422") + + + + + + + pubmed:23294633 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) + + + + + + + pubmed:27373205 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) positiveCorrelation p(CONSO:"phosphatase-activating domain") + + + + + + + pubmed:27373205 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) positiveCorrelation p(CONSO:"Tau dimers") + + + + + + + pubmed:27373205 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) decreases bp(GO:"anterograde axonal transport") + + + + + + + pubmed:22299660 + + p(FPLX:PPP2C, pmod(go:0006479 ! "protein methylation")) increases complex(p(FPLX:"PPP2R_A"), p(FPLX:"PPP2R_B"), p(FPLX:PPP2C)) + + + + + + + pubmed:22299660 + + p(HGNC:ICMT) increases p(FPLX:PPP2C, pmod(go:0006479 ! "protein methylation")) + + + + + + + pubmed:22299660 + + p(HGNC:ICMT) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:22299660 + + p(FPLX:PPP2C, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) decreases act(p(FPLX:PPP2)) + + + + + + + pubmed:22299660 + + p(FPLX:PPP2C, pmod(go:0006468 ! "protein phosphorylation", Tyr, 307)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:22299660 + + p(FPLX:PPP2C, pmod(go:0006479 ! "protein methylation", Leu, 309)) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:22299660 + + p(FPLX:PPP2C, pmod(go:0006479 ! "protein methylation", Leu, 309)) decreases complex(p(FPLX:"PPP2R_A"), p(FPLX:"PPP2R_B"), p(FPLX:PPP2C)) + + + + + + + pubmed:22299660 + + p(FPLX:PPP2C, pmod(go:0006468 ! "protein phosphorylation")) association a(MESH:"Neurofibrillary Tangles") + + + + + + + pubmed:28083634 + + p(HGNC:OTUB1) decreases p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) + + + + + + + + + pubmed:28083634 + + p(HGNC:OTUB1) increases complex(p(HGNC:MAPT), p(HGNC:OTUB1)) + + + + + + + pubmed:28083634 + + p(HGNC:OTUB1) increases complex(p(HGNC:MAPT), p(HGNC:OTUB1)) + + + + + + + pubmed:28083634 + + p(HGNC:OTUB1) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:28083634 + + p(HGNC:OTUB1) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:28083634 + + p(HGNC:OTUB1) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:28083634 + + p(HGNC:OTUB1) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:28083634 + + p(HGNC:OTUB1) negativeCorrelation a(CONSO:"Tau aggregates") + + + + + + + pubmed:28083634 + + p(HGNC:OTUB1) regulates p(HGNC:MAPT) + + + + + + + pubmed:28083634 + + p(HGNC:OTUB1) increases p(HGNC:MAPT) + + + + + + + pubmed:28083634 + + p(HGNC:OTUB1) decreases deg(p(HGNC:MAPT)) + + + + + + + pubmed:28083634 + + p(HGNC:OTUB1) regulates deg(p(HGNC:MAPT)) + + + + + + + pubmed:28083634 + + p(HGNC:OTUB1) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) + + + + + + + pubmed:28083634 + + p(HGNC:OTUB1) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) + + + + + + + pubmed:28083634 + + p(HGNC:OTUB1) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) + + + + + + + pubmed:28083634 + + p(HGNC:OTUB1) increases a(CONSO:"Tau oligomers") + + + + + + + pubmed:28083634 + + p(HGNC:OTUB1) increases a(CONSO:"Tau oligomers") + + + + + + + pubmed:28083634 + + p(HGNC:OTUB1) decreases p(HGNC:MAPT, pmod(go:0070936 ! "protein K48-linked ubiquitination")) + + + + + + + pubmed:28083634 + + p(HGNC:OTUB1) causesNoChange p(HGNC:MAPT, pmod(go:0070534 ! "protein K63-linked ubiquitination")) + + + + + + + + + + + pubmed:28083634 + + complex(p(HGNC:MAPT), p(HGNC:OTUB1)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:28083634 + + complex(p(HGNC:MAPT), p(HGNC:OTUB1)) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:28083634 + + p(HGNC:USP5) decreases p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) + + + + + + + + + pubmed:28083634 + + p(HGNC:USP5) increases complex(p(HGNC:MAPT), p(HGNC:USP5)) + + + + + + + pubmed:28083634 + + p(HGNC:USP5) causesNoChange a(CONSO:"Tau aggregates") + + + + + + + pubmed:28083634 + + p(HGNC:USP9X) decreases p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) + + + + + + + + + pubmed:28083634 + + p(HGNC:USP9X) increases complex(p(HGNC:MAPT), p(HGNC:USP9X)) + + + + + + + pubmed:28083634 + + p(HGNC:USP9X) causesNoChange a(CONSO:"Tau aggregates") + + + + + + + pubmed:28083634 + + p(HGNC:OTUB1, var("p.Cys91Ala")) causesNoChange p(HGNC:MAPT, pmod(go:0070936 ! "protein K48-linked ubiquitination")) + + + + + + + pubmed:28083634 + + p(HGNC:OTUB1, var("p.Cys91Ala")) causesNoChange deg(p(HGNC:MAPT)) + + + + + + + pubmed:28083634 + + p(HGNC:OTUB1, var("p.Cys91Ala")) causesNoChange p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) + + + + + + + pubmed:28083634 + + p(HGNC:OTUB1, frag("?")) decreases p(HGNC:MAPT, pmod(go:0070936 ! "protein K48-linked ubiquitination")) + + + + + + + pubmed:28083634 + + p(HGNC:OTUB1, frag("?")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) + + + + + + + pubmed:28083634 + + p(MGI:Otub1) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) + + + + + + + pubmed:28083634 + + p(MGI:Otub1) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) + + + + + + + pubmed:28083634 + + p(MGI:Otub1) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) + + + + + + + pubmed:28083634 + + p(MGI:Otub1) increases p(MGI:Mapt) + + + + + + + pubmed:28083634 + + p(MGI:Otub1) increases a(CONSO:"Tau oligomers") + + + + + + + pubmed:28083634 + + p(MGI:Otub1) increases a(CONSO:"Tau oligomers") + + + + + + + pubmed:28083634 + + p(MGI:Otub1) increases a(CONSO:"Tau oligomers") + + + + + + + + + + + pubmed:28083634 + + p(MGI:Otub1, var("p.Cys91Ala")) causesNoChange p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) + + + + + + + pubmed:28083634 + + p(MGI:Otub1, var("p.Cys91Ala")) causesNoChange a(CONSO:"Tau oligomers") + + + + + + + pubmed:28083634 + + p(MGI:Otub1, frag("?")) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) + + + + + + + pubmed:30362565 + + path(MESH:Autophagy) association path(MESH:"Huntington Disease") + + + + + + + pubmed:30837838 + + path(MESH:Autophagy) association p(HGNC:MAP1LC3A, loc(GO:"inclusion body")) + + + + + + + pubmed:30837838 + + path(MESH:Autophagy) association p(HGNC:SQSTM1, loc(GO:"inclusion body")) + + + + + + + pubmed:30837838 + + path(MESH:Autophagy) association deg(p(HGNC:TARDBP)) + + + + + + + pubmed:30837838 + + path(MESH:Autophagy) decreases p(HGNC:TARDBP) + + + + + + + pubmed:30837838 + + path(MESH:Autophagy) increases path(MESH:"Cytotoxicity, Immunologic") + + + + + + + pubmed:30837838 + + path(MESH:Autophagy) increases deg(p(CONSO:"TDP-43 aggregates")) + + + + + + + pubmed:28148553 + + bp(GO:"metabolic process") association a(CHEBI:"3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide") + + + + + + + pubmed:30362565 + + p(HGNCGENEFAMILY:"Pyruvate dehydrogenase complex") increases path(MESH:"Carbohydrate Metabolism") + + + + + + + pubmed:20556492 + + p(HGNCGENEFAMILY:"Pyruvate dehydrogenase complex") negativeCorrelation path(HP:"Caudate atrophy") + + + + + + + pubmed:30362565 + + path(MESH:"Carbohydrate Metabolism") decreases path(MESH:"Lipid Metabolism") + + + + + + + pubmed:30362565 + + path(MESH:"Lipid Metabolism") increases path(CONSO:"mitochondrial dysfunction") + + + + + + + pubmed:30362565 + + path(MESH:"Lipid Metabolism") increases a(CHEBI:radical) + + + + + + + pubmed:30362565 + + path(MESH:"Lipid Metabolism") decreases path(MESH:"Carbohydrate Metabolism") + + + + + + + pubmed:30362565 + + a(CHEBI:meldonium) isA a(MESH:"Cardiotonic Agents") + + + + + + + pubmed:30362565 + + a(CHEBI:meldonium) increases a(CHEBI:"adenosine triphosphate") + + + + + + + pubmed:30362565 + + a(CHEBI:meldonium) regulates path(MESH:"Energy Metabolism") + + + + + + + pubmed:30362565 + + a(CHEBI:meldonium) regulates path(MESH:"Energy Metabolism") + + + + + + + pubmed:30362565 + + a(CHEBI:meldonium) decreases a(DRUGBANK:L-Carnitine, loc(GO:intracellular)) + + + + + + + pubmed:30362565 + + a(CHEBI:meldonium) decreases a(CHEBI:"hydroxy-fatty acyl-L-carnitine") + + + + + + + pubmed:30362565 + + a(CHEBI:meldonium) decreases path(MESH:"Lipid Metabolism") + + + + + + + pubmed:30362565 + + a(CHEBI:meldonium) increases path(MESH:"Lipid Metabolism") + + + + + + + pubmed:30362565 + + a(CHEBI:meldonium) decreases path(MESH:Inflammation) + + + + + + + pubmed:30362565 + + a(CHEBI:meldonium) decreases path(MESH:Apoptosis) + + + + + + + pubmed:30362565 + + a(CHEBI:meldonium) increases path(MESH:"Recognition (Psychology)") + + + + + + + pubmed:30362565 + + a(CHEBI:meldonium) increases path(MESH:"Spatial Learning") + + + + + + + pubmed:30362565 + + a(CHEBI:meldonium) decreases p(HGNC:APP) + + + + + + + pubmed:30362565 + + a(CHEBI:meldonium) increases path(MESH:"Cell Survival") + + + + + + + pubmed:30362565 + + a(CHEBI:meldonium) decreases p(CONSO:"huntingtin aggregates") + + + + + + + pubmed:30362565 + + a(CHEBI:meldonium) increases r(HGNC:PPARGC1A) + + + + + + + pubmed:30362565 + + a(CHEBI:meldonium) increases r(HGNC:PPARGC1A) + + + + + + + pubmed:30362565 + + a(CHEBI:meldonium) increases path(MESH:"Cell Enlargement") + + + + + + + pubmed:30362565 + + a(CHEBI:meldonium) increases path(MESH:Longevity) + + + + + + + pubmed:30362565 + + a(CHEBI:meldonium) decreases path(MESH:"Motor Skills Disorders") + + + + + + + pubmed:30362565 + + a(CHEBI:meldonium) decreases path(MESH:Ataxia) + + + + + + + + + pubmed:30362565 + + a(MESH:"4'-azidothymidine") increases path(MESH:"Neurotoxicity Syndromes") + + + + + + + pubmed:30362565 + + p(HGNC:HTT, var("Glu")) increases path(MESH:"Cytotoxicity, Immunologic") + + + + + + + pubmed:30362565 + + p(HGNC:HTT, var("Glu")) decreases r(HGNC:PPARGC1A) + + + + + + + pubmed:30362565 + + p(HGNC:HTT, var("Glu")) decreases r(HGNC:PPARGC1A) + + + + + + + pubmed:30362565 + + p(HGNC:HTT, var("Glu")) decreases p(HGNC:PPARGC1A) + + + + + + + + + pubmed:30362565 + + p(HGNC:HTT, var("Glu")) increases a(CHEBI:"reactive oxygen species") + + + + + + + pubmed:30362565 + + composite(a(CHEBI:meldonium), p(HGNC:HTT, var("Glu"))) increases r(HGNC:PPARGC1A) + + + + + + + pubmed:30362565 + + composite(a(CHEBI:meldonium), p(HGNC:HTT, var("Glu"))) decreases a(CHEBI:"reactive oxygen species") + + + + + + + pubmed:30012004 + + bp(GO:"dopamine metabolic process") negativeCorrelation path(MESH:"Huntington Disease") + + + + + + + pubmed:30012004 + + bp(GO:"D-glutamate metabolic process") negativeCorrelation path(MESH:"Huntington Disease") + + + + + + + pubmed:30012004 + + bp(GO:"cannabinoid biosynthetic process") negativeCorrelation path(MESH:"Huntington Disease") + + + + + + + pubmed:30012004 + + bp(GO:"adenosine catabolic process") negativeCorrelation path(MESH:"Huntington Disease") + + + + + + + pubmed:30012004 + + bp(GO:"psychomotor behavior") negativeCorrelation path(MESH:"Huntington Disease") + + + + + + + pubmed:30012004 + + bp(GO:"visual learning") negativeCorrelation path(MESH:"Huntington Disease") + + + + + + + pubmed:22179319 + + path(MESH:Metabolism) association p(HGNC:SIRT1) + + + + + + + pubmed:19933700 + + path(MESH:Metabolism) association p(HGNC:PPP2R1A) + + + + + + + pubmed:22179319 + + p(NCBIGENE:34708) causesNoChange p(HGNC:HTT, pmod(CONSO:"CAG repeats")) + + + + + + + pubmed:22179319 + + p(NCBIGENE:34708) causesNoChange bp(MESH:Neuroprotection) + + + + + + + pubmed:27574109 + + path(MESH:"Pick Disease of the Brain") positiveCorrelation p(CONSO:"3R tau") + + + + + + + pubmed:26655600 + + path(MESH:"Pick Disease of the Brain") positiveCorrelation p(CONSO:"3R tau", loc(GO:"Pick body")) + + + + + + + pubmed:27574109 + + path(MESH:"Pick Disease of the Brain") positiveCorrelation p(CONSO:"4R tau") + + + + + + + pubmed:27574109 + + path(MESH:"Pick Disease of the Brain") positiveCorrelation p(HGNC:MAPT) + + + + + + + pubmed:27574109 + + path(MESH:"Pick Disease of the Brain") positiveCorrelation p(HGNC:MAPT) + + + + + + + pubmed:27574109 + + path(MESH:"Pick Disease of the Brain") positiveCorrelation p(CONSO:"phosphatase-activating domain") + + + + + + + pubmed:27574109 + + path(MESH:"Pick Disease of the Brain") positiveCorrelation a(CONSO:"Tau oligomers") + + + + + + + pubmed:27574109 + + path(MESH:"Pick Disease of the Brain") positiveCorrelation a(CONSO:"Tau oligomers") + + + + + + + pubmed:27574109 + + path(MESH:"Pick Disease of the Brain") positiveCorrelation composite(p(CONSO:"phosphatase-activating domain"), p(HGNC:MAPT)) + + + + + + + pubmed:29311797 + + path(MESH:"Pick Disease of the Brain") isA path(MESH:Tauopathies) + + + + + + + pubmed:27260836 + + path(MESH:"Pick Disease of the Brain") positiveCorrelation complex(GO:"Pick body") + + + + + + + pubmed:22057784 + + path(MESH:"Pick Disease of the Brain") positiveCorrelation p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 18)) + + + + + + + pubmed:22057784 + + path(MESH:"Pick Disease of the Brain") positiveCorrelation p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) + + + + + + + pubmed:22057784 + + path(MESH:"Pick Disease of the Brain") positiveCorrelation p(HGNC:MAPT, pmod(go:0017014 ! "protein nitrosylation", Tyr, 29)) + + + + + + + pubmed:30837838 + + path(MESH:"Pick Disease of the Brain") association p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation"), loc(GO:"inclusion body")) + + + + + + + pubmed:30837838 + + path(MESH:"Pick Disease of the Brain") association p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination"), loc(GO:"inclusion body")) + + + + + + + pubmed:22179319 + + path(MESH:Eating) association p(HGNC:HTT, pmod(CONSO:"CAG repeats")) + + + + + + + pubmed:22179319 + + p(HGNC:PPP1R1B) decreases bp(GO:"striatal medium spiny neuron differentiation") + + + + + + + pubmed:22179319 + + p(HGNC:PPP1R1B) association p(HGNC:BDNF) + + + + + + + pubmed:23393546 + + p(HGNC:PPP1R1B) association bp(GO:"dopamine receptor signaling pathway") + + + + + + + pubmed:23393546 + + p(HGNC:PPP1R1B) association bp(GO:"serotonin receptor signaling pathway") + + + + + + + pubmed:23393546 + + p(HGNC:PPP1R1B) prognosticBiomarkerFor path(DOID:"Huntington's disease") + + + + + + + pubmed:22179319 + + path(MESH:"Caloric Restriction") increases p(HGNC:BDNF) + + + + + + + pubmed:27013968 + + act(p(HGNC:NTRK2, pmod(go:0006468 ! "protein phosphorylation"))) regulates a(CHEBI:dopamine) + + + + + + + pubmed:27013968 + + act(p(HGNC:NTRK2, pmod(go:0006468 ! "protein phosphorylation"))) regulates a(CHEBI:"2',3'-cyclic AMP") + + + + + + + pubmed:22179319 + + p(HGNC:SIRT1, pmod(go:0006473 ! "protein acetylation")) association p(HGNC:HTT, pmod(CONSO:"CAG repeats")) + + + + + + + pubmed:20556492 + + bp(GO:"regulation of succinate dehydrogenase activity") negativeCorrelation path(DOID:"Huntington's disease") + + + + + + + pubmed:20556492 + + bp(GO:"tricarboxylic acid cycle") negativeCorrelation path(DOID:"Huntington's disease") + + + + + + + pubmed:20556492 + + path(HP:"Caudate atrophy") decreases act(p(HGNC:ACO2)) + + + + + + + pubmed:20556492 + + path(HP:"Caudate atrophy") negativeCorrelation p(HGNCGENEFAMILY:"Pyruvate dehydrogenase complex") + + + + + + + pubmed:21722302 + + bp(GO:"negative regulation of mitochondrial membrane potential") increases bp(GO:"release of cytochrome c from mitochondria") + + + + + + + pubmed:20556492 + + path(DOID:neuroblastoma) increases p(HGNC:HTT, pmod(CONSO:"CAG repeats"), loc(GO:"mitochondrial outer membrane")) + + + + + + + pubmed:21722302 + + complex(GO:"mitochondrial permeability transition pore complex") directlyIncreases bp(GO:"regulation of mitochondrial membrane potential") + + + + + + + pubmed:21722302 + + complex(GO:"mitochondrial permeability transition pore complex") increases bp(GO:"release of cytochrome c from mitochondria") + + + + + + + pubmed:21722302 + + complex(GO:"mitochondrial permeability transition pore complex") increases p(MESH:Caspases) + + + + + + + pubmed:20556492 + + a(CHEBI:"cyclosporin A") decreases complex(GO:"mitochondrial permeability transition pore complex") + + + + + + + pubmed:20556492 + + a(CHEBI:"cyclosporin A") decreases complex(GO:"mitochondrial permeability transition pore complex") + + + + + + + pubmed:20556492 + + a(CHEBI:"cyclosporin A") increases bp(GO:"calcium import into the mitochondrion") + + + + + + + pubmed:20556492 + + a(CHEBI:"cyclosporin A") decreases act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) + + + + + + + pubmed:20556492 + + a(CHEBI:"cyclosporin A") decreases bp(GO:"calcium ion import") + + + + + + + pubmed:20556492 + + a(CHEBI:"cyclosporin A") regulates bp(GO:"regulation of membrane potential") + + + + + + + pubmed:20556492 + + a(CHEBI:ADP) increases bp(GO:"regulation of membrane potential") + + + + + + + pubmed:20556492 + + complex(p(HGNC:HTT, pmod(CONSO:"CAG repeats")), p(HGNC:ITPR1, frag("?"))) increases act(p(HGNC:ITPR1)) + + + + + + + + + pubmed:20556492 + + a(CHEBI:"bongkrekic acid") decreases complex(GO:"mitochondrial permeability transition pore complex") + + + + + + + pubmed:20556492 + + a(CHEBI:"bongkrekic acid") decreases act(p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) + + + + + + + pubmed:20556492 + + a(CHEBI:"bongkrekic acid") decreases bp(GO:"calcium ion import") + + + + + + + pubmed:20556492 + + a(CHEBI:"bongkrekic acid") regulates bp(GO:"regulation of membrane potential") + + + + + + + pubmed:20556492 + + complex(p(HGNC:HTT, pmod(CONSO:"CAG repeats")), p(HGNCGENEFAMILY:"Calcium voltage-gated channel alpha1 subunits")) increases bp(GO:"regulation of voltage-gated calcium channel activity") + + + + + + + + + pubmed:20556492 + + complex(p(HGNC:HTT, pmod(CONSO:"CAG repeats")), p(HGNCGENEFAMILY:"Calcium voltage-gated channel auxiliary alpha2delta subunits")) increases bp(GO:"regulation of voltage-gated calcium channel activity") + + + + + + + + + pubmed:20556492 + + p(FB:htt, pmod(CONSO:"CAG repeats")) increases path(HP:Neurodegeneration) + + + + + + + + + pubmed:20556492 + + p(FB:Ca-alpha1D) decreases path(HP:Neurodegeneration) + + + + + + + pubmed:20556492 + + complex(p(HGNC:CREBBP), p(HGNC:HTT, pmod(CONSO:"CAG repeats")), p(HGNC:TAF4)) negativeCorrelation act(p(HGNC:CREBBP), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) + + + + + + + pubmed:20556492 + + complex(p(HGNC:CREBBP), p(HGNC:HTT, pmod(CONSO:"CAG repeats")), p(HGNC:TAF4)) increases path(MESH:"Cytotoxicity, Immunologic") + + + + + + + pubmed:20556492 + + complex(p(HGNC:CREBBP), p(HGNC:HTT, pmod(CONSO:"CAG repeats")), p(HGNC:TAF4)) increases p(HGNC:HTT, pmod(CONSO:"CAG repeats")) + + + + + + + + + + + pubmed:28173111 + + bp(MESH:"Mitochondrial Dynamics") negativeCorrelation r(MGI:Dnm1l) + + + + + + + pubmed:28420982 + + bp(GO:"mitochondrion organization") decreases bp(HP:Neurodegeneration) + + + + + + + pubmed:20556492 + + complex(p(HGNC:NRF1), p(HGNC:PPARG), p(HGNC:PPARGC1A)) regulates bp(GO:"cellular respiration") + + + + + + + pubmed:27299292 + + bp(GO:"lipid biosynthetic process") negativeCorrelation p(HGNC:TFEB) + + + + + + + pubmed:20556492 + + complex(p(HGNC:CREBBP), p(HGNC:TAF4)) regulates r(HGNC:PPARGC1A) + + + + + + + pubmed:20556492 + + a(CHEBI:thiazolidinediones) decreases path(DOID:"Alzheimer's disease") + + + + + + + pubmed:20556492 + + a(CHEBI:thiazolidinediones) decreases path(DOID:"Parkinson's disease") + + + + + + + pubmed:20556492 + + a(CHEBI:thiazolidinediones) decreases path(DOID:"amyotrophic lateral sclerosis") + + + + + + + pubmed:20556492 + + a(CHEBI:thiazolidinediones) decreases path(EFO:stroke) + + + + + + + pubmed:20556492 + + a(CHEBI:thiazolidinediones) decreases path(DOID:"multiple sclerosis") + + + + + + + pubmed:29687724 + + path(MESH:Dystonia) association path(MESH:"Huntington Disease") + + + + + + + pubmed:29687724 + + path(MESH:Dystonia) association path(MESH:"Neural Pathways") + + + + + + + pubmed:29687724 + + path(MESH:Dystonia) association a(CHEBI:dopamine) + + + + + + + pubmed:29687724 + + path(MESH:"Neural Pathways") association path(MESH:Chorea) + + + + + + + pubmed:29687724 + + path(MESH:"Neural Pathways") association path(MESH:Dystonia) + + + + + + + pubmed:29687724 + + path(MESH:"Neural Pathways") association path(MESH:"Huntington Disease") + + + + + + + pubmed:29687724 + + a(CHEBI:risperidone) decreases a(CHEBI:dopamine) + + + + + + + pubmed:29687724 + + a(CHEBI:risperidone) decreases path(MESH:Chorea) + + + + + + + pubmed:29687724 + + a(CHEBI:risperidone) decreases path(MESH:Dystonia) + + + + + + + pubmed:29687724 + + a(CHEBI:risperidone) decreases path(MESH:"Stereotypic Movement Disorder") + + + + + + + + + + + pubmed:29687724 + + a(CHEBI:olanzapine) decreases a(CHEBI:dopamine) + + + + + + + pubmed:29687724 + + a(CHEBI:olanzapine) decreases path(MESH:Chorea) + + + + + + + pubmed:29687724 + + a(CHEBI:olanzapine) decreases path(MESH:Dystonia) + + + + + + + pubmed:29687724 + + a(PUBCHEM:73437646) isA a(PUBCHEM:6018) + + + + + + + pubmed:29687724 + + a(PUBCHEM:73437646) decreases path(MESH:Chorea) + + + + + + + pubmed:29687724 + + path(MESH:"Schizophrenia, Disorganized") association path(MESH:"Huntington Disease") + + + + + + + pubmed:29687724 + + path(MESH:"Schizophrenia, Disorganized") decreases path(MESH:Movement) + + + + + + + pubmed:29687724 + + a(CHEBI:valproate) decreases path(MESH:"Irritable Mood") + + + + + + + pubmed:29687724 + + a(CHEBI:valproate) decreases path(MESH:Aggression) + + + + + + + pubmed:29687724 + + a(CHEBI:carbamazepine) decreases path(MESH:"Irritable Mood") + + + + + + + pubmed:29687724 + + a(CHEBI:carbamazepine) decreases path(MESH:Aggression) + + + + + + + pubmed:29687724 + + a(MESH:"Serotonin Uptake Inhibitors") decreases path(MESH:"Irritable Mood") + + + + + + + pubmed:29687724 + + a(MESH:"Serotonin Uptake Inhibitors") decreases path(MESH:Aggression) + + + + + + + pubmed:29687724 + + a(MESH:"Serotonin Uptake Inhibitors") decreases path(MESH:"Obsessive-Compulsive Disorder") + + + + + + + pubmed:29687724 + + a(MESH:"Serotonin Uptake Inhibitors") decreases path(HP:Rigidity) + + + + + + + pubmed:30988501 + + a(MESH:"Serotonin Uptake Inhibitors") decreases p(HGNC:IL6) + + + + + + + pubmed:30988501 + + a(MESH:"Serotonin Uptake Inhibitors") decreases p(HGNC:IL1B) + + + + + + + pubmed:29687724 + + a(CHEBI:clomipramine) decreases path(MESH:"Obsessive-Compulsive Disorder") + + + + + + + pubmed:29687724 + + a(CHEBI:clomipramine) decreases path(HP:Rigidity) + + + + + + + pubmed:26195256 + + path(MESH:Thinking) decreases path(MESH:"Alzheimer Disease") + + + + + + + pubmed:29687724 + + a(PUBCHEM:33032) increases bp(GO:cognition) + + + + + + + pubmed:29687724 + + a(PUBCHEM:33032) increases bp(GO:"motor behavior") + + + + + + + pubmed:29687724 + + a(CHEBI:amantadine) decreases a(PUBCHEM:33032) + + + + + + + pubmed:29687724 + + a(CHEBI:amantadine) association path(MESH:"Huntington Disease") + + + + + + + pubmed:29687724 + + a(CHEBI:amantadine) decreases p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits") + + + + + + + pubmed:29687724 + + a(PUBCHEM:9795739) decreases a(CHEBI:dopamine) + + + + + + + pubmed:29687724 + + a(PUBCHEM:9795739) association path(MESH:"Huntington Disease") + + + + + + + pubmed:29687724 + + a(PUBCHEM:9795739) causesNoChange bp(GO:"motor behavior") + + + + + + + pubmed:27013968 + + p(HGNC:HTT, pmod(HBP:"CAG repeats")) increases path(MESH:"Huntington Disease") + + + + + + + pubmed:27013968 + + p(HGNC:HTT, pmod(HBP:"CAG repeats")) association path(MESH:"Huntington Disease") + + + + + + + pubmed:27013968 + + p(HGNC:HTT, pmod(HBP:"CAG repeats")) negativeCorrelation bp(GO:"synaptic transmission, dopaminergic") + + + + + + + pubmed:27013968 + + p(HGNC:HTT, pmod(HBP:"CAG repeats")) negativeCorrelation bp(GO:"synaptic transmission, glutamatergic") + + + + + + + pubmed:27013968 + + p(HGNC:HTT, pmod(HBP:"CAG repeats")) negativeCorrelation bp(GO:"mRNA transcription") + + + + + + + pubmed:27013968 + + p(HGNC:HTT, pmod(HBP:"CAG repeats")) negativeCorrelation p(HGNC:PDE10A) + + + + + + + pubmed:27013968 + + p(HGNC:HTT, pmod(HBP:"CAG repeats")) negativeCorrelation p(HGNC:PTPN5) + + + + + + + pubmed:27013968 + + p(HGNC:HTT, pmod(HBP:"CAG repeats")) negativeCorrelation p(HGNC:RASD2) + + + + + + + pubmed:27013968 + + p(HGNC:HTT, pmod(HBP:"CAG repeats")) negativeCorrelation act(p(HGNC:BDNF), ma(GO:"brain-derived neurotrophic factor binding")) + + + + + + + pubmed:27013968 + + p(HGNC:HTT, pmod(HBP:"CAG repeats")) decreases p(HGNC:BDNF) + + + + + + + pubmed:27013968 + + p(HGNC:HTT, pmod(HBP:"CAG repeats")) negativeCorrelation act(p(HGNC:NTRK2), ma(GO:"neurotrophin TRKB receptor binding")) + + + + + + + pubmed:27013968 + + p(HGNC:HTT, pmod(HBP:"CAG repeats")) decreases r(HGNC:BDNF) + + + + + + + pubmed:27013968 + + p(HGNC:HTT, pmod(HBP:"CAG repeats")) decreases bp(GO:"ERK1 and ERK2 cascade") + + + + + + + + + pubmed:27013968 + + a(MESH:"Basal Ganglia") increases act(a(GO:"glutamatergic synapse", loc(MESH:Thalamus))) + + + + + + + pubmed:27013968 + + a(MESH:"Basal Ganglia") increases act(a(GO:"dopaminergic synapse")) + + + + + + + pubmed:27013968 + + act(a(GO:"dopaminergic synapse")) increases bp(GO:"locomotory behavior") + + + + + + + pubmed:14556719 + + a(GO:"dopaminergic synapse") association a(MESH:"Lewy Bodies") + + + + + + + pubmed:27013968 + + p(HGNC:PDE10A) negativeCorrelation p(HGNC:HTT, pmod(HBP:"CAG repeats")) + + + + + + + pubmed:27013968 + + p(HGNC:RASD2) negativeCorrelation p(HGNC:HTT, pmod(HBP:"CAG repeats")) + + + + + + + pubmed:27013968 + + complex(p(HGNC:BDNF), p(HGNC:NTRK2)) increases bp(MESH:"Cell Survival") + + + + + + + pubmed:27013968 + + complex(p(HGNC:BDNF), p(HGNC:NTRK2)) decreases path(MESH:"Huntington Disease") + + + + + + + pubmed:27013968 + + complex(p(HGNC:BDNF), p(HGNC:NTRK2)) increases p(HGNC:NTRK2, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:27013968 + + complex(p(HGNC:BDNF), p(HGNC:NTRK2)) increases p(PFAM:DARPP-32) + + + + + + + pubmed:23393546 + + complex(p(HGNC:BDNF), p(HGNC:NTRK2)) increases bp(GO:"ERK1 and ERK2 cascade") + + + + + + + pubmed:27013968 + + g(HGNC:BDNF) increases p(HGNC:BDNF) + + + + + + + pubmed:27013968 + + a(CHEBI:"2',3'-cyclic AMP") regulates p(PFAM:DARPP-32) + + + + + + + pubmed:27013968 + + p(PFAM:DARPP-32) increases bp(GO:"cellular process") + + + + + + + pubmed:27013968 + + composite(p(HGNC:BDNF), p(HGNC:HTT, pmod(HBP:"CAG repeats"))) increases bp(GO:"maintenance of cell number") + + + + + + + pubmed:27013968 + + composite(p(HGNC:BDNF), p(HGNC:HTT, pmod(HBP:"CAG repeats"))) decreases bp(MESH:"Cell Survival") + + + + + + + pubmed:27013968 + + composite(p(HGNC:BDNF), p(HGNC:HTT, pmod(HBP:"CAG repeats"))) increases bp(MESH:Apoptosis) + + + + + + + pubmed:27013968 + + composite(p(HGNC:BDNF), p(HGNC:HTT, pmod(HBP:"CAG repeats"))) decreases p(PFAM:DARPP-32) + + + + + + + pubmed:27013968 + + composite(p(HGNC:BDNF), p(HGNC:HTT, pmod(HBP:"CAG repeats"))) decreases p(HGNC:NTRK2, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:27013968 + + composite(p(HGNC:BDNF), p(HGNC:HTT, pmod(HBP:"CAG repeats"))) increases p(HGNC:MAPK1, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:27013968 + + composite(p(HGNC:BDNF), p(HGNC:HTT, pmod(HBP:"CAG repeats"))) increases p(HGNC:MAPK3, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:21722302 + + path(HP:Dyskinesia) prognosticBiomarkerFor path(MESH:"Parkinson Disease") + + + + + + + pubmed:30027901 + + path(HP:"Cognitive impairment") decreases bp(GO:"motor learning") + + + + + + + pubmed:30027901 + + path(HP:"Cognitive impairment") increases path(HP:"Neurological speech impairment") + + + + + + + pubmed:30027901 + + path(HP:"Cognitive impairment") increases path(MESH:"Perceptual Disorders") + + + + + + + pubmed:30027901 + + path(HP:"Abnormal putamen morphology") increases bp(GO:"neuron death") + + + + + + + pubmed:30027901 + + complex(p(HGNC:HTT, pmod(CONSO:"CAG repeats")), p(MESH:Proteins)) decreases act(p(MESH:Proteins)) + + + + + + + pubmed:30027901 + + path(MESH:"Westphal disease") association path(MESH:"Huntington Disease") + + + + + + + pubmed:30027901 + + path(MESH:"Westphal disease") increases path(HP:Hypokinesia) + + + + + + + pubmed:30027901 + + path(MESH:"Westphal disease") decreases path(MESH:"Motor Activity") + + + + + + + pubmed:30027901 + + bp(GO:"intracellular transport") association act(p(HGNC:HTT)) + + + + + + + pubmed:30027901 + + bp(GO:"intracellular transport") association p(HGNC:HTT) + + + + + + + pubmed:25784053 + + bp(GO:"intracellular transport") association p(FPLX:"CCT_complex") + + + + + + + pubmed:21722302 + + bp(CONSO:"protein aggregation") increases bp(MESH:"Cell Death") + + + + + + + pubmed:21722302 + + bp(CONSO:"protein aggregation") association path(MESH:"Neurodegenerative Diseases") + + + + + + + pubmed:21722302 + + bp(CONSO:"protein aggregation") association path(MESH:"Alzheimer Disease") + + + + + + + pubmed:21722302 + + bp(CONSO:"protein aggregation") association path(MESH:"Parkinson Disease") + + + + + + + pubmed:21722302 + + bp(CONSO:"protein aggregation") association path(MESH:"Amyloidosis, Cerebral, with Spongiform Encephalopathy") + + + + + + + pubmed:21722302 + + bp(CONSO:"protein aggregation") association path(MESH:"Brain Injuries, Traumatic") + + + + + + + pubmed:21722302 + + bp(CONSO:"protein aggregation") association path(MESH:"Brain Ischemia") + + + + + + + pubmed:21722302 + + bp(CONSO:"protein aggregation") increases a(MESH:"Prion Proteins") + + + + + + + pubmed:21722302 + + bp(CONSO:"protein aggregation") increases a(CONSO:"amyloid-beta aggregates") + + + + + + + pubmed:30027901 + + path(HP:"Abnormality of the cerebral subcortex") decreases bp(GO:"learning or memory") + + + + + + + + + + + + + + + + + + + + + pubmed:30027901 + + p(HGNC:GAD1) increases a(CHEBI:"gamma-aminobutyric acid") + + + + + + + pubmed:23393546 + + p(HGNC:GAD1) association path(DOID:"Huntington's disease") + + + + + + + pubmed:23393546 + + p(HGNC:GAD1) association path(DOID:"Huntington's disease") + + + + + + + pubmed:30027901 + + path(HP:"Cerebellar atrophy") decreases a(CONSO:"Purkinje cell layer of cerebellar cortex") + + + + + + + pubmed:29221819 + + a(CONSO:"Purkinje cell layer of cerebellar cortex") negativeCorrelation p(MGI:Dyrk1a) + + + + + + + pubmed:30027901 + + p(HGNC:TH) increases a(CHEBI:dopamine) + + + + + + + pubmed:29191965 + + p(HGNC:TH) regulates a(CHEBI:dopamine) + + + + + + + + + pubmed:29191965 + + p(HGNC:TH) regulates a(CHEBI:serotonin) + + + + + + + pubmed:29191965 + + p(HGNC:TH) regulates act(p(HGNC:DDC)) + + + + + + + + + pubmed:30027901 + + a(MESH:"Hydroxyindoleacetic Acid") association a(CHEBI:serotonin) + + + + + + + pubmed:30027901 + + p(HGNC:CTH) increases a(CHEBI:L-cysteine) + + + + + + + pubmed:30027901 + + a(CHEBI:L-cysteine) increases bp(MESH:Neuroprotection) + + + + + + + + + + + pubmed:22908190 + + p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination")) increases deg(p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination"))) + + + + + + + + + pubmed:22908190 + + p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination")) increases complex(a(GO:"proteasome regulatory particle"), p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination"))) + + + + + + + + + + + pubmed:27181519 + + p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination")) negativeCorrelation bp(GO:"stress granule assembly") + + + + + + + pubmed:27181519 + + p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination"), loc(GO:"proteasome complex")) increases deg(p(MESH:Proteins)) + + + + + + + pubmed:30027901 + + p(HGNC:HTT, frag("1_17"), pmod(CONSO:"CAG repeats")) increases tloc(p(HGNC:HTT, pmod(CONSO:"CAG repeats")), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) + + + + + + + pubmed:30027901 + + p(HGNC:HTT, frag("1_17"), pmod(CONSO:"CAG repeats")) regulates a(CONSO:"huntingtin aggregates") + + + + + + + pubmed:30027901 + + p(HGNC:HTT, frag("1_17"), pmod(CONSO:"CAG repeats"), pmod(go:0006468 ! "protein phosphorylation")) regulates a(CONSO:"huntingtin aggregates") + + + + + + + pubmed:30027901 + + bp(GO:"nuclear pore complex assembly") increases bp(GO:"nucleocytoplasmic transport") + + + + + + + + + + + pubmed:30027901 + + act(p(HGNC:ZDHHC17)) regulates bp(GO:"intracellular transport") + + + + + + + + + pubmed:30027901 + + p(HGNC:HTT, pmod(CONSO:"CAG repeats"), pmod(go:0018345 ! "protein palmitoylation", Cys, 214)) decreases act(p(HGNC:ZDHHC17)) + + + + + + + pubmed:30027901 + + p(HGNC:ZDHHC17, pmod(go:0018345 ! "protein palmitoylation")) increases act(p(HGNC:ZDHHC17)) + + + + + + + pubmed:30740335 + + a(MESH:"Protein Aggregates") increases path(HBP:proteotoxicity) + + + + + + + pubmed:27299292 + + path(MESH:"Protein Aggregation, Pathological") negativeCorrelation bp(GO:"autophagosome assembly") + + + + + + + pubmed:27299292 + + path(MESH:"Protein Aggregation, Pathological") negativeCorrelation act(p(HGNC:TFEB)) + + + + + + + pubmed:27299292 + + path(MESH:"Protein Aggregation, Pathological") decreases p(HGNC:TPP1) + + + + + + + pubmed:27299292 + + path(MESH:"Protein Aggregation, Pathological") negativeCorrelation bp(GO:autophagy) + + + + + + + pubmed:25784053 + + path(MESH:"Protein Aggregation, Pathological") association bp(CONSO:Proteostasis) + + + + + + + pubmed:25784053 + + path(MESH:"Protein Aggregation, Pathological") association path(MESH:"Neurodegenerative Diseases") + + + + + + + pubmed:25784053 + + path(MESH:"Protein Aggregation, Pathological") negativeCorrelation p(HGNC:HSPA1A) + + + + + + + pubmed:25784053 + + path(MESH:"Protein Aggregation, Pathological") negativeCorrelation p(HGNC:HSPA1B) + + + + + + + pubmed:25784053 + + path(MESH:"Protein Aggregation, Pathological") negativeCorrelation p(HGNC:DNAJB1) + + + + + + + pubmed:24706768 + + path(MESH:"Protein Aggregation, Pathological") decreases act(p(HGNC:HSPA8)) + + + + + + + pubmed:24706768 + + path(MESH:"Protein Aggregation, Pathological") decreases bp(GO:"clathrin-dependent endocytosis") + + + + + + + pubmed:27574109 + + path(MESH:"Protein Aggregation, Pathological") positiveCorrelation p(CONSO:"3R tau") + + + + + + + pubmed:27574109 + + path(MESH:"Protein Aggregation, Pathological") positiveCorrelation p(CONSO:"3R tau") + + + + + + + pubmed:27574109 + + path(MESH:"Protein Aggregation, Pathological") positiveCorrelation p(CONSO:"4R tau") + + + + + + + pubmed:27574109 + + path(MESH:"Protein Aggregation, Pathological") positiveCorrelation p(CONSO:"4R tau") + + + + + + + pubmed:27574109 + + path(MESH:"Protein Aggregation, Pathological") positiveCorrelation p(CONSO:"Tau isoform F (441 aa)") + + + + + + + pubmed:28669544 + + path(MESH:"Protein Aggregation, Pathological") association path(DOID:"neurodegenerative disease") + + + + + + + pubmed:30837838 + + path(MESH:"Protein Aggregation, Pathological") association complex(p(HGNC:TARDBP, frag("1_102")), p(HGNC:TARDBP, frag("1_102"))) + + + + + + + pubmed:30027901 + + r(HGNC:HTT) increases complex(p(HGNC:HTT), p(HGNC:OPTN)) + + + + + + + pubmed:30027901 + + complex(p(HGNC:HTT), p(HGNC:OPTN)) increases bp(GO:"regulation of autophagosome assembly") + + + + + + + + + pubmed:30116051 + + p(HGNC:OPTN) association path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:30837838 + + p(HGNC:OPTN) association path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + + + pubmed:27181519 + + p(HGNC:OPTN) association path(DOID:"amyotrophic lateral sclerosis") + + + + + + + + + + + pubmed:27181519 + + p(HGNC:OPTN) increases bp(GO:autophagy) + + + + + + + pubmed:27181519 + + p(HGNC:OPTN) increases deg(p(HGNC:HTT, var("?"))) + + + + + + + + + + + + + + + + + + + + + + + + + + + pubmed:30027901 + + a(MESH:Autophagosomes) association p(HGNC:HTT) + + + + + + + pubmed:24027553 + + a(MESH:Autophagosomes) positiveCorrelation a(CONSO:"Tau aggregates") + + + + + + + pubmed:24027553 + + a(MESH:Autophagosomes) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:30027901 + + composite(a(MESH:Autophagosomes), a(MESH:Lysosomes)) increases bp(GO:autophagy) + + + + + + + pubmed:21722302 + + composite(a(MESH:Autophagosomes), a(MESH:Lysosomes)) increases deg(a(MESH:Autophagosomes)) + + + + + + + + + pubmed:30027901 + + a(MESH:Lysosomes) association p(HGNC:HTT) + + + + + + + + + pubmed:26968346 + + act(a(MESH:Lysosomes)) decreases tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) + + + + + + + pubmed:26968346 + + a(MESH:Lysosomes) decreases tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) + + + + + + + pubmed:26968346 + + a(MESH:Lysosomes) increases p(HGNCGENEFAMILY:"MTOR complex 1") + + + + + + + pubmed:30108137 + + act(a(MESH:Lysosomes)) increases bp(GO:"ATP export") + + + + + + + pubmed:27299292 + + act(a(MESH:Lysosomes)) negativeCorrelation path(CONSO:"protein aggregation") + + + + + + + pubmed:27299292 + + act(a(MESH:Lysosomes)) increases path(DOID:"pancreatic ductal adenocarcinoma") + + + + + + + pubmed:27299292 + + act(a(MESH:Lysosomes)) increases deg(p(HGNC:APP, var("?"))) + + + + + + + pubmed:25784053 + + a(MESH:Lysosomes) increases bp(MESH:Proteolysis) + + + + + + + pubmed:25784053 + + a(MESH:Lysosomes) decreases path(MESH:"Protein Aggregation, Pathological") + + + + + + + pubmed:24027553 + + a(MESH:Lysosomes) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + + + pubmed:29238289 + + act(a(MESH:Lysosomes)) decreases tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:30027901 + + composite(a(MESH:"Cytoplasmic Vesicles"), p(HGNC:BDNF)) association p(HGNC:HTT) + + + + + + + + + + + pubmed:30027901 + + composite(a(CHEBI:"gamma-aminobutyric acid"), a(MESH:"Cytoplasmic Vesicles")) association p(HGNC:HTT) + + + + + + + pubmed:30027901 + + p(MGI:Pcm1) increases tloc(p(MGI:Pcm1), fromLoc(GO:"Golgi apparatus"), toLoc(GO:"plasma membrane")) + + + + + + + pubmed:30027901 + + p(MGI:Pcm1) increases a(GO:cilium) + + + + + + + + + + + pubmed:29311797 + + bp(GO:"regulation of cell cycle") association p(HGNC:HSP90AA1) + + + + + + + pubmed:22142809 + + bp(GO:"regulation of cell cycle") association p(HGNC:CAV2) + + + + + + + pubmed:22142809 + + bp(GO:"regulation of cell cycle") association p(HGNC:GNB4) + + + + + + + pubmed:22142809 + + bp(GO:"regulation of cell cycle") association p(HGNC:LIPA) + + + + + + + pubmed:30027901 + + bp(GO:"chaperone-mediated protein folding") regulates p(MESH:Proteins, pmod(CONSO:misfolded)) + + + + + + + pubmed:30027901 + + bp(GO:"lysosomal microautophagy") increases deg(p(MESH:Proteins, pmod(CONSO:misfolded))) + + + + + + + pubmed:30562574 + + bp(GO:"lysosomal microautophagy") increases tloc(a(MESH:"Cytoplasmic Vesicles"), fromLoc(GO:cytoplasm), toLoc(GO:lysosome)) + + + + + + + pubmed:22908190 + + bp(GO:"lysosomal microautophagy") increases tloc(a(GO:cytoplasm), fromLoc(GO:intracellular), toLoc(GO:lysosome)) + + + + + + + pubmed:22908190 + + bp(GO:"lysosomal microautophagy") increases tloc(a(GO:cytoplasm), fromLoc(GO:intracellular), toLoc(GO:"multivesicular body")) + + + + + + + pubmed:18930136 + + bp(GO:"lysosomal microautophagy") increases tloc(a(GO:cytoplasm), fromLoc(GO:intracellular), toLoc(GO:lysosome)) + + + + + + + pubmed:29626319 + + bp(GO:"lysosomal microautophagy") increases bp(GO:"cellular protein catabolic process") + + + + + + + pubmed:29626319 + + bp(GO:"lysosomal microautophagy") increases deg(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:29626319 + + bp(GO:"lysosomal microautophagy") increases deg(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:29626319 + + bp(GO:"lysosomal microautophagy") increases deg(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:29626319 + + bp(GO:"lysosomal microautophagy") decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:29626319 + + bp(GO:"lysosomal microautophagy") increases p(HGNC:MAPT, frag("?")) + + + + + + + pubmed:27491084 + + bp(CONSO:Proteostasis) association p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") + + + + + + + pubmed:27491084 + + bp(CONSO:Proteostasis) association p(HGNC:HSPD1) + + + + + + + pubmed:27491084 + + bp(CONSO:Proteostasis) association p(FPLX:HSPA) + + + + + + + pubmed:27491084 + + bp(CONSO:Proteostasis) association p(HGNC:TPR) + + + + + + + pubmed:27491084 + + bp(CONSO:Proteostasis) association p(FPLX:HSPB) + + + + + + + pubmed:27491084 + + bp(CONSO:Proteostasis) association p(FPLX:HSP90) + + + + + + + pubmed:29311797 + + bp(CONSO:Proteostasis) association p(FPLX:HSP90) + + + + + + + pubmed:27491084 + + bp(CONSO:Proteostasis) association p(HGNCGENEFAMILY:"AAA ATPases") + + + + + + + pubmed:23746257 + + bp(CONSO:Proteostasis) association bp(GO:"inflammatory response") + + + + + + + pubmed:23746257 + + bp(CONSO:Proteostasis) association bp(GO:"response to oxidative stress") + + + + + + + pubmed:23746257 + + bp(CONSO:Proteostasis) association bp(GO:"behavioral response to starvation") + + + + + + + pubmed:23746257 + + bp(CONSO:Proteostasis) negativeCorrelation bp(GO:"cell death") + + + + + + + pubmed:25784053 + + bp(CONSO:Proteostasis) association bp(MESH:"Protein Biosynthesis") + + + + + + + pubmed:25784053 + + bp(CONSO:Proteostasis) association bp(GO:"protein folding") + + + + + + + pubmed:25784053 + + bp(CONSO:Proteostasis) association path(MESH:"Protein Aggregation, Pathological") + + + + + + + pubmed:25784053 + + bp(CONSO:Proteostasis) association bp(MESH:Proteolysis) + + + + + + + pubmed:25784053 + + bp(CONSO:Proteostasis) decreases bp(MESH:Aging) + + + + + + + pubmed:21882945 + + bp(CONSO:Proteostasis) regulates p(HGNC:MAPT) + + + + + + + pubmed:21882945 + + bp(CONSO:Proteostasis) regulates a(MESH:Proteins) + + + + + + + pubmed:27181519 + + bp(CONSO:Proteostasis) negativeCorrelation path(DOID:"amyotrophic lateral sclerosis") + + + + + + + pubmed:30027901 + + path(HP:Parkinsonism) increases path(HP:"Abnormal saccadic eye movements") + + + + + + + pubmed:30027901 + + path(HP:Parkinsonism) increases path(DOID:"cerebellar ataxia") + + + + + + + pubmed:30027901 + + bp(GO:"cellular response to drug") decreases path(MESH:Chorea) + + + + + + + pubmed:30027901 + + bp(GO:"cellular response to drug") decreases a(CHEBI:dopamine) + + + + + + + pubmed:30027901 + + bp(GO:"cellular response to drug") decreases p(HGNCGENEFAMILY:"Dopamine receptors") + + + + + + + pubmed:30027901 + + a(CHEBI:reserpine) decreases path(MESH:"Huntington Disease") + + + + + + + pubmed:30027901 + + a(CHEBI:tetrabenazine) decreases path(MESH:"Huntington Disease") + + + + + + + pubmed:30027901 + + a(CHEBI:tetrabenazine) decreases path(MESH:"Huntington Disease") + + + + + + + pubmed:30027901 + + a(CHEBI:tetrabenazine) decreases p(HGNC:SLC18A2) + + + + + + + pubmed:30027901 + + a(CHEBI:tetrabenazine) decreases a(CHEBI:dopamine) + + + + + + + pubmed:30027901 + + a(CHEBI:tetrabenazine) decreases a(CHEBI:serotonin) + + + + + + + pubmed:30027901 + + a(CHEBI:tetrabenazine) decreases a(DRUGBANK:Norepinephrine) + + + + + + + pubmed:30027901 + + a(CHEBI:tetrabenazine) decreases path(HP:Hyperkinesis) + + + + + + + pubmed:30027901 + + a(CHEBI:tetrabenazine) decreases path(HP:Hyperkinesis) + + + + + + + pubmed:30027901 + + a(CHEBI:tetrabenazine) decreases path(MESH:Chorea) + + + + + + + pubmed:30027901 + + a(CHEBI:tetrabenazine) decreases path(MESH:Chorea) + + + + + + + pubmed:30027901 + + a(CHEBI:phenothiazines) decreases path(MESH:"Huntington Disease") + + + + + + + pubmed:21882945 + + a(CHEBI:phenothiazines) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:30027901 + + a(MESH:Butyrophenones) decreases path(MESH:"Huntington Disease") + + + + + + + pubmed:30027901 + + composite(a(CHEBI:"lithium carbonate"), a(CHEBI:haloperidol)) causesNoChange path(MESH:Chorea) + + + + + + + pubmed:30027901 + + composite(a(CHEBI:"lithium carbonate"), a(CHEBI:haloperidol)) decreases path(HP:Irritability) + + + + + + + pubmed:30027901 + + composite(a(CHEBI:"lithium carbonate"), a(CHEBI:haloperidol)) decreases path(MESH:Anger) + + + + + + + pubmed:30027901 + + composite(a(CHEBI:"lithium carbonate"), a(CHEBI:haloperidol)) decreases path(MESH:Depression) + + + + + + + + + pubmed:30027901 + + a(CHEBI:"lithium carbonate") causesNoChange path(MESH:Chorea) + + + + + + + pubmed:30027901 + + a(MESH:Placebos) causesNoChange path(MESH:Chorea) + + + + + + + pubmed:30027901 + + a(PUBCHEM:5467) causesNoChange path(MESH:"Motor Disorders") + + + + + + + pubmed:30027901 + + a(CHEBI:muscimol) increases complex(GO:"GABA receptor complex") + + + + + + + pubmed:30027901 + + a(CHEBI:muscimol) causesNoChange path(MESH:"Motor Disorders") + + + + + + + pubmed:30027901 + + a(CHEBI:muscimol) causesNoChange path(HP:"Cognitive impairment") + + + + + + + pubmed:30027901 + + a(CHEBI:muscimol) decreases path(MESH:Chorea) + + + + + + + pubmed:30027901 + + a(CHEBI:muscimol) decreases path(HP:Hyperkinesis) + + + + + + + pubmed:30027901 + + a(CHEBI:muscimol) increases path(DOID:dystonia) + + + + + + + pubmed:30027901 + + a(DRUGBANK:Pridopidine) decreases p(HGNC:DRD2) + + + + + + + pubmed:30027901 + + p(HGNC:COQ10A) association act(complex(GO:"mitochondrial respiratory chain complex I")) + + + + + + + pubmed:30027901 + + p(HGNC:COQ10A) decreases path(MESH:"Huntington Disease") + + + + + + + pubmed:30027901 + + p(HGNC:COQ10A) causesNoChange path(MESH:"Huntington Disease") + + + + + + + pubmed:30027901 + + act(complex(GO:"mitochondrial respiratory chain complex I")) association p(HGNC:COQ10A) + + + + + + + pubmed:26631930 + + act(complex(GO:"mitochondrial respiratory chain complex I")) decreases p(HGNC:SRSF2) + + + + + + + pubmed:30027901 + + a(DRUGBANK:Remacemide) decreases a(CHEBI:"N-methyl-D-aspartic acid") + + + + + + + pubmed:30027901 + + a(DRUGBANK:Remacemide) causesNoChange path(MESH:"Huntington Disease") + + + + + + + pubmed:30027901 + + a(DRUGBANK:Remacemide) increases path(HP:Nausea) + + + + + + + pubmed:30027901 + + a(DRUGBANK:Remacemide) increases path(HP:Vomiting) + + + + + + + pubmed:30027901 + + a(DRUGBANK:Remacemide) increases path(MESH:Dizziness) + + + + + + + pubmed:30027901 + + a(CHEBI:creatine) decreases bp(MESH:"Oxidative Stress") + + + + + + + pubmed:30027901 + + a(CHEBI:creatine) decreases path(HP:Neurodegeneration) + + + + + + + pubmed:30027901 + + a(CHEBI:creatine) causesNoChange bp(MESH:"Muscle Strength") + + + + + + + pubmed:30027901 + + a(CHEBI:creatine) causesNoChange bp(GO:cognition) + + + + + + + pubmed:30027901 + + tloc(a(CHEBI:"D-glutamate residue"), fromLoc(GO:cytoplasm), toLoc(GO:"extracellular space")) association path(MESH:"Huntington Disease") + + + + + + + pubmed:30027901 + + p(HGNCGENEFAMILY:Interleukins) biomarkerFor bp(MESH:Neuroprotection) + + + + + + + pubmed:30027901 + + a(CHEBI:"8-hydroxy-2'-deoxyguanosine") biomarkerFor bp(MESH:Neuroprotection) + + + + + + + pubmed:23393546 + + p(HGNC:NF2) positiveCorrelation bp(GO:"ERK1 and ERK2 cascade") + + + + + + + pubmed:23393546 + + a(CHEBI:pizotifen) increases bp(MESH:"Cell Survival") + + + + + + + pubmed:23393546 + + a(CHEBI:pizotifen) causesNoChange bp(MESH:"Cell Survival") + + + + + + + pubmed:23393546 + + a(CHEBI:pizotifen) increases bp(GO:"MAPK cascade") + + + + + + + pubmed:23393546 + + a(CHEBI:pizotifen) increases bp(GO:"MAPK cascade") + + + + + + + pubmed:23393546 + + a(CHEBI:pizotifen) increases bp(GO:"motor behavior") + + + + + + + pubmed:23393546 + + a(CHEBI:pizotifen) increases bp(GO:"motor behavior") + + + + + + + pubmed:23393546 + + a(CHEBI:pizotifen) increases bp(GO:"motor behavior") + + + + + + + pubmed:23393546 + + a(CHEBI:pizotifen) increases bp(GO:"motor behavior") + + + + + + + pubmed:23393546 + + a(CHEBI:pizotifen) decreases path(CONSO:Neurodegeneration) + + + + + + + pubmed:23393546 + + a(CHEBI:pizotifen) decreases path(MESH:"Striatal Degeneration, Autosomal Dominant") + + + + + + + pubmed:23393546 + + a(CHEBI:pizotifen) increases a(CHEBI:"adenosine triphosphate") + + + + + + + pubmed:23393546 + + a(CHEBI:pizotifen) causesNoChange a(CHEBI:"adenosine triphosphate") + + + + + + + pubmed:23393546 + + a(CHEBI:pizotifen) decreases p(HGNC:CASP3) + + + + + + + pubmed:23393546 + + a(CHEBI:pizotifen) decreases p(HGNC:CASP7) + + + + + + + pubmed:23393546 + + a(CHEBI:pizotifen) increases p(HGNC:MAPK3, pmod(go:0006468 ! "protein phosphorylation", Thr, 202)) + + + + + + + pubmed:23393546 + + a(CHEBI:pizotifen) decreases p(HGNC:MAPK3, pmod(go:0006468 ! "protein phosphorylation", Thr, 202)) + + + + + + + pubmed:23393546 + + a(CHEBI:pizotifen) decreases p(HGNC:MAPK3, pmod(go:0006468 ! "protein phosphorylation", Thr, 202)) + + + + + + + pubmed:23393546 + + a(CHEBI:pizotifen) increases p(HGNC:MAPK1, pmod(go:0006468 ! "protein phosphorylation", Tyr, 204)) + + + + + + + pubmed:23393546 + + a(CHEBI:pizotifen) increases p(HGNC:MAPK1, pmod(go:0006468 ! "protein phosphorylation", Tyr, 204)) + + + + + + + pubmed:23393546 + + a(CHEBI:pizotifen) increases p(HGNC:MAPK3, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:23393546 + + a(CHEBI:pizotifen) increases p(HGNC:MAPK3, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:23393546 + + a(CHEBI:pizotifen) increases p(HGNC:MAPK3, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:23393546 + + a(CHEBI:pizotifen) increases p(HGNC:MAPK1, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:23393546 + + a(CHEBI:pizotifen) increases p(HGNC:MAPK1, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:23393546 + + a(CHEBI:pizotifen) increases p(HGNC:MAPK1, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + + + pubmed:23393546 + + a(CHEBI:pizotifen) decreases a(CHEBI:serotonin) + + + + + + + pubmed:23393546 + + a(CHEBI:pizotifen) decreases path(DOID:migraine) + + + + + + + pubmed:23393546 + + a(CHEBI:pizotifen) increases p(HGNC:HTR1A) + + + + + + + pubmed:23393546 + + a(CHEBI:pizotifen) increases p(HGNC:PPP1R1B) + + + + + + + pubmed:23393546 + + a(CHEBI:pizotifen) increases p(HGNC:PPP1R1B) + + + + + + + pubmed:23393546 + + a(CHEBI:pizotifen) increases p(HGNC:PPP1R1B) + + + + + + + pubmed:23393546 + + a(CHEBI:pizotifen) increases p(HGNC:GRM2) + + + + + + + pubmed:23393546 + + a(CHEBI:pizotifen) increases p(HGNC:GRM3) + + + + + + + pubmed:23393546 + + a(CHEBI:pizotifen) causesNoChange p(HGNC:DRD2) + + + + + + + pubmed:23393546 + + a(CHEBI:pizotifen) causesNoChange p(HGNC:GAD2) + + + + + + + pubmed:23393546 + + a(CHEBI:pizotifen) causesNoChange p(HGNC:GAD1) + + + + + + + pubmed:23393546 + + a(CHEBI:pizotifen) causesNoChange p(HGNC:HTR1B) + + + + + + + pubmed:23393546 + + a(CHEBI:pizotifen) decreases bp(GO:"negative regulation of cell volume") + + + + + + + pubmed:23393546 + + a(CHEBI:pizotifen) decreases bp(GO:"negative regulation of cell volume") + + + + + + + pubmed:23393546 + + a(CHEBI:pizotifen) isA a(CHEBI:"neuroprotective agent") + + + + + + + pubmed:23393546 + + a(CHEBI:pizotifen) causesNoChange p(HGNC:HTT) + + + + + + + pubmed:23393546 + + a(CHEBI:pizotifen) decreases path(MESH:Neuropathology) + + + + + + + pubmed:23393546 + + a(CHEBI:cyproheptadine) increases a(CHEBI:"adenosine triphosphate") + + + + + + + pubmed:23393546 + + a(CHEBI:cyproheptadine) causesNoChange a(CHEBI:"adenosine triphosphate") + + + + + + + pubmed:23393546 + + a(CHEBI:cyproheptadine) decreases p(HGNC:CASP3) + + + + + + + pubmed:23393546 + + a(CHEBI:cyproheptadine) decreases p(HGNC:CASP7) + + + + + + + pubmed:23393546 + + a(CHEBI:cyproheptadine) causesNoChange bp(MESH:"Cell Survival") + + + + + + + pubmed:23393546 + + a(CHEBI:cyproheptadine) increases p(HGNC:MAPK3, pmod(go:0006468 ! "protein phosphorylation", Thr, 202)) + + + + + + + pubmed:23393546 + + a(CHEBI:cyproheptadine) increases p(HGNC:MAPK1, pmod(go:0006468 ! "protein phosphorylation", Tyr, 204)) + + + + + + + pubmed:23393546 + + a(CHEBI:loxapine) increases a(CHEBI:"adenosine triphosphate") + + + + + + + pubmed:23393546 + + a(CHEBI:loxapine) causesNoChange a(CHEBI:"adenosine triphosphate") + + + + + + + pubmed:23393546 + + a(CHEBI:loxapine) decreases p(HGNC:CASP3) + + + + + + + pubmed:23393546 + + a(CHEBI:loxapine) causesNoChange bp(MESH:"Cell Survival") + + + + + + + pubmed:23393546 + + a(CHEBI:loxapine) increases p(HGNC:MAPK3, pmod(go:0006468 ! "protein phosphorylation", Thr, 202)) + + + + + + + pubmed:23393546 + + a(CHEBI:loxapine) increases p(HGNC:MAPK1, pmod(go:0006468 ! "protein phosphorylation", Tyr, 204)) + + + + + + + pubmed:23393546 + + p(HGNC:MAPK3, pmod(go:0006468 ! "protein phosphorylation", Thr, 202)) increases bp(GO:"MAPK cascade") + + + + + + + pubmed:23393546 + + p(HGNC:MAPK1, pmod(go:0006468 ! "protein phosphorylation", Tyr, 204)) increases bp(GO:"MAPK cascade") + + + + + + + pubmed:23393546 + + a(CHEBI:"dimethyl sulfoxide") increases p(HGNC:MAPK3, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:23393546 + + a(CHEBI:"dimethyl sulfoxide") increases p(HGNC:MAPK1, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:23393546 + + composite(a(CHEBI:pizotifen), p(HGNC:MAPK1, pmod(go:0006468 ! "protein phosphorylation")), p(HGNC:MAPK3, pmod(go:0006468 ! "protein phosphorylation"))) increases bp(MESH:"Cell Survival") + + + + + + + + + pubmed:23393546 + + a(MESH:"desmethyl-WAY 100635") decreases act(a(CHEBI:pizotifen)) + + + + + + + pubmed:23393546 + + a(MESH:"desmethyl-WAY 100635") decreases act(p(HGNC:MAPK3)) + + + + + + + pubmed:23393546 + + a(MESH:"desmethyl-WAY 100635") decreases act(p(HGNC:MAPK1)) + + + + + + + pubmed:23393546 + + a(MESH:"desmethyl-WAY 100635") increases complex(a(CHEBI:serotonin), p(HGNC:HTR1A)) + + + + + + + pubmed:23393546 + + complex(a(CHEBI:serotonin), p(HGNC:HTR1A)) decreases act(p(HGNC:MAPK3)) + + + + + + + pubmed:23393546 + + complex(a(CHEBI:serotonin), p(HGNC:HTR1A)) decreases act(p(HGNC:MAPK1)) + + + + + + + pubmed:23393546 + + a(DRUGBANK:Robalzotan) decreases p(HGNC:HTR1A) + + + + + + + pubmed:23393546 + + complex(a(CHEBI:risperidone), p(HGNCGENEFAMILY:"5-hydroxytryptamine receptors, G protein-coupled")) increases act(a(CHEBI:risperidone), ma(GO:"serotonin receptor activity")) + + + + + + + + + + + + + + + + + pubmed:23393546 + + complex(a(CHEBI:metergoline), p(HGNCGENEFAMILY:"5-hydroxytryptamine receptors, G protein-coupled")) increases act(a(CHEBI:metergoline), ma(GO:"serotonin receptor activity")) + + + + + + + + + pubmed:23393546 + + complex(a(CHEBI:ketanserin), p(HGNCGENEFAMILY:"5-hydroxytryptamine receptors, G protein-coupled")) increases act(a(CHEBI:ketanserin), ma(GO:"serotonin receptor activity")) + + + + + + + pubmed:23393546 + + complex(a(CHEBI:spiperone), p(HGNCGENEFAMILY:"5-hydroxytryptamine receptors, G protein-coupled")) increases act(a(CHEBI:spiperone), ma(GO:"serotonin receptor activity")) + + + + + + + + + pubmed:23393546 + + complex(a(CHEBI:promethazine), p(HGNCGENEFAMILY:"5-hydroxytryptamine receptors, G protein-coupled")) increases act(a(CHEBI:promethazine), ma(GO:"serotonin receptor activity")) + + + + + + + + + pubmed:23393546 + + a(CHEBI:promethazine) increases bp(MESH:"Cell Survival") + + + + + + + pubmed:23393546 + + a(CHEBI:promethazine) decreases p(HGNC:HRH1) + + + + + + + pubmed:23393546 + + a(CHEBI:promethazine) decreases path(DOID:"Huntington's disease") + + + + + + + pubmed:23393546 + + a(CHEBI:cetirizine) decreases p(HGNC:HRH1) + + + + + + + pubmed:23393546 + + a(CHEBI:cetirizine) causesNoChange bp(MESH:"Cell Survival") + + + + + + + pubmed:23393546 + + a(CHEBI:diphenhydramine) decreases p(HGNC:HRH1) + + + + + + + pubmed:23393546 + + a(CHEBI:diphenhydramine) causesNoChange bp(MESH:"Cell Survival") + + + + + + + pubmed:23393546 + + a(CHEBI:ketotifen) decreases p(HGNC:HRH1) + + + + + + + pubmed:23393546 + + a(CHEBI:ketotifen) causesNoChange bp(MESH:"Cell Survival") + + + + + + + pubmed:23393546 + + a(CHEBI:desloratadine) decreases p(HGNC:HRH1) + + + + + + + pubmed:23393546 + + a(CHEBI:desloratadine) causesNoChange bp(MESH:"Cell Survival") + + + + + + + pubmed:23393546 + + a(CHEBI:levochlorpheniramine) decreases p(HGNC:HRH1) + + + + + + + pubmed:23393546 + + a(CHEBI:levochlorpheniramine) causesNoChange bp(MESH:"Cell Survival") + + + + + + + pubmed:23393546 + + bp(GO:"dopamine receptor signaling pathway") association p(HGNC:PPP1R1B) + + + + + + + pubmed:23393546 + + bp(GO:"serotonin receptor signaling pathway") association p(HGNC:PPP1R1B) + + + + + + + pubmed:23393546 + + p(HGNC:GAD2) association path(DOID:"Huntington's disease") + + + + + + + pubmed:23393546 + + p(HGNC:GAD2) association path(DOID:"Huntington's disease") + + + + + + + pubmed:23393546 + + p(HGNC:GRIA3) association path(DOID:"Huntington's disease") + + + + + + + pubmed:23393546 + + p(HGNC:HTR1B) association path(DOID:"Huntington's disease") + + + + + + + pubmed:23393546 + + p(HGNC:HTR1B) association path(DOID:"Huntington's disease") + + + + + + + pubmed:19933700 + + p(HGNC:KPNB1) association bp(GO:"nuclear transport") + + + + + + + + + pubmed:19933700 + + bp(GO:"nuclear transport") association p(HGNC:KPNB1) + + + + + + + pubmed:19933700 + + a(CHEBI:Trypsin) increases complex(p(HGNC:HTT, frag("1254_*")), p(HGNC:HTT, frag("1_1184"))) + + + + + + + + + + + pubmed:19933700 + + p(HGNCGENEFAMILY:"Polycomb repressive complex 2") regulates r(HGNC:HOXB1) + + + + + + + pubmed:19933700 + + p(HGNCGENEFAMILY:"Polycomb repressive complex 2") regulates r(HGNC:HOXB2) + + + + + + + pubmed:19933700 + + p(HGNCGENEFAMILY:"Polycomb repressive complex 2") regulates r(HGNC:HOXB9) + + + + + + + + + pubmed:19933700 + + path(MESH:"Cell Differentiation") increases r(NCBIGENE:2350) + + + + + + + pubmed:19933700 + + r(NCBIGENE:2350) increases path(MESH:"X Chromosome Inactivation") + + + + + + + pubmed:19933700 + + p(CONSO:"Histone H3", pmod(mod:00430 ! "trimethylated residue", Lys, 27)) association p(HGNC:HTT) + + + + + + + + + + + + + + + + + + + + + pubmed:19933700 + + p(HGNCGENEFAMILY:"Polycomb repressive complex 2", var("?")) increases p(CONSO:"Histone H3", pmod(mod:00430 ! "trimethylated residue", Lys, 27)) + + + + + + + + + pubmed:21861815 + + p(MESH:"Hypoxia-Inducible Factor 1") positiveCorrelation a(PUBCHEM:6918822) + + + + + + + pubmed:21861815 + + act(p(MESH:"Hypoxia-Inducible Factor 1")) increases bp(GO:"cellular response to oxygen-glucose deprivation") + + + + + + + pubmed:21861815 + + act(p(MESH:"Hypoxia-Inducible Factor 1")) increases bp(GO:"cellular response to oxidative stress") + + + + + + + pubmed:21861815 + + act(p(MESH:"Hypoxia-Inducible Factor 1")) increases bp(NCIT:C16559) + + + + + + + pubmed:21861815 + + act(p(MESH:"Hypoxia-Inducible Factor 1")) increases bp(GO:angiogenesis) + + + + + + + pubmed:21861815 + + act(p(MESH:"Hypoxia-Inducible Factor 1")) decreases a(CHEBI:amyloid-beta) + + + + + + + pubmed:21861815 + + act(p(MESH:"Hypoxia-Inducible Factor 1")) decreases path(DOID:"Alzheimer's disease") + + + + + + + pubmed:21861815 + + act(p(MESH:"Hypoxia-Inducible Factor 1")) negativeCorrelation path(DOID:"Parkinson's disease") + + + + + + + pubmed:21861815 + + p(MESH:"Hypoxia-Inducible Factor 1") decreases path(DOID:"Parkinson's disease") + + + + + + + pubmed:21861815 + + p(MESH:"Hypoxia-Inducible Factor 1") increases a(CHEBI:dopamine) + + + + + + + pubmed:21861815 + + p(MESH:"Hypoxia-Inducible Factor 1") increases tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:21861815 + + p(MESH:"Hypoxia-Inducible Factor 1") increases a(CHEBI:ATP) + + + + + + + pubmed:21861815 + + p(MESH:"Hypoxia-Inducible Factor 1") increases a(CHEBI:NADPH) + + + + + + + pubmed:21861815 + + p(MESH:"Hypoxia-Inducible Factor 1") increases bp(NCIT:C16407) + + + + + + + pubmed:21861815 + + act(p(MESH:"Hypoxia-Inducible Factor 1")) decreases act(p(HGNC:HTT, pmod(CONSO:"CAG repeats"))) + + + + + + + pubmed:21861815 + + p(MESH:"Hypoxia-Inducible Factor 1") increases bp(GO:"cell redox homeostasis") + + + + + + + pubmed:21861815 + + p(MESH:"Hypoxia-Inducible Factor 1") increases p(HGNC:ENO1) + + + + + + + pubmed:21861815 + + p(MESH:"Hypoxia-Inducible Factor 1") increases p(HGNC:VEGFA) + + + + + + + pubmed:21861815 + + p(MESH:"Hypoxia-Inducible Factor 1") increases p(HGNC:BDNF) + + + + + + + + + + + pubmed:21861815 + + p(HGNCGENEFAMILY:"Basic helix-loop-helix proteins") increases p(MESH:"Hypoxia-Inducible Factor 1") + + + + + + + pubmed:21861815 + + p(PFAM:PAS) increases p(MESH:"Hypoxia-Inducible Factor 1") + + + + + + + pubmed:21861815 + + bp(GO:"response to hypoxia") increases tloc(p(HGNC:HIF1A), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) + + + + + + + pubmed:21861815 + + bp(GO:"response to hypoxia") increases act(p(HGNC:RWDD3)) + + + + + + + pubmed:21861815 + + bp(GO:"response to hypoxia") increases act(p(HGNC:VEGFA)) + + + + + + + pubmed:21861815 + + bp(GO:"response to hypoxia") increases bp(GO:"cell death") + + + + + + + pubmed:21861815 + + complex(p(HGNC:ARNT), p(HGNC:HIF1A), loc(GO:nucleus)) increases act(p(MESH:"Hypoxia-Inducible Factor 1")) + + + + + + + pubmed:21861815 + + complex(p(MESH:"Hypoxia-Inducible Factor 1"), p(NCIT:C13718)) increases p(HGNC:CREBBP) + + + + + + + pubmed:21861815 + + complex(p(MESH:"Hypoxia-Inducible Factor 1"), p(NCIT:C13718)) increases p(HGNC:EP300) + + + + + + + + + pubmed:21861815 + + p(NCIT:C13718) increases p(HGNC:VEGFA) + + + + + + + pubmed:21861815 + + p(NCIT:C13718) decreases path(DOID:neuropathy) + + + + + + + pubmed:21861815 + + act(p(NCIT:C13718)) negativeCorrelation path(DOID:"amyotrophic lateral sclerosis") + + + + + + + + + pubmed:21861815 + + p(NCIT:C13718) regulates r(HGNC:TH) + + + + + + + pubmed:21861815 + + p(HGNC:EGLN2) increases p(HGNC:HIF1A, pmod(go:0018126 ! "protein hydroxylation", Pro, 402)) + + + + + + + pubmed:21861815 + + p(HGNC:EGLN2) increases p(HGNC:HIF1A, pmod(go:0018126 ! "protein hydroxylation", Pro, 546)) + + + + + + + pubmed:21861815 + + p(HGNC:HIF1A, pmod(go:0018126 ! "protein hydroxylation", Pro, 402)) increases complex(p(HGNC:HIF1A), p(HGNC:VHL)) + + + + + + + pubmed:21861815 + + p(HGNC:EGLN1) increases p(HGNC:HIF1A, pmod(go:0018126 ! "protein hydroxylation", Pro, 402)) + + + + + + + pubmed:21861815 + + p(HGNC:EGLN1) increases p(HGNC:HIF1A, pmod(go:0018126 ! "protein hydroxylation", Pro, 546)) + + + + + + + pubmed:25036637 + + p(HGNC:EGLN1) association p(HGNC:FKBP5) + + + + + + + pubmed:25036637 + + p(HGNC:EGLN1) association p(INTERPRO:"Zinc finger, MYND-type") + + + + + + + + + pubmed:21861815 + + p(HGNC:EGLN3) increases p(HGNC:HIF1A, pmod(go:0018126 ! "protein hydroxylation", Pro, 402)) + + + + + + + pubmed:21861815 + + p(HGNC:EGLN3) increases p(HGNC:HIF1A, pmod(go:0018126 ! "protein hydroxylation", Pro, 546)) + + + + + + + pubmed:21861815 + + composite(a(CHEBI:"2-oxoglutarate(1-)"), a(CHEBI:"iron(2+)"), a(CHEBI:dioxygen)) increases act(p(HGNC:EGLN2)) + + + + + + + pubmed:21861815 + + composite(a(CHEBI:"2-oxoglutarate(1-)"), a(CHEBI:"iron(2+)"), a(CHEBI:dioxygen)) increases act(p(HGNC:EGLN1)) + + + + + + + pubmed:21861815 + + composite(a(CHEBI:"2-oxoglutarate(1-)"), a(CHEBI:"iron(2+)"), a(CHEBI:dioxygen)) increases act(p(HGNC:EGLN3)) + + + + + + + + + pubmed:21861815 + + complex(p(HGNC:HIF1A), p(HGNC:VHL)) increases p(HGNC:HIF1A, pmod(go:0016567 ! "protein ubiquitination")) + + + + + + + pubmed:21861815 + + complex(p(HGNC:HIF1A), p(HGNC:VHL)) increases deg(p(HGNC:HIF1A)) + + + + + + + + + + + + + + + + + pubmed:21861815 + + p(HGNC:HIF1A, pmod(go:0016567 ! "protein ubiquitination")) increases composite(p(HGNC:HIF1A, pmod(go:0016567 ! "protein ubiquitination")), p(NCIT:C13970)) + + + + + + + pubmed:21861815 + + composite(p(HGNC:HIF1A, pmod(go:0016567 ! "protein ubiquitination")), p(NCIT:C13970)) increases deg(p(HGNC:HIF1A)) + + + + + + + + + pubmed:21861815 + + a(CHEBI:"iron chelator") decreases p(HGNC:EGLN2) + + + + + + + pubmed:21861815 + + a(CHEBI:"iron chelator") decreases p(HGNC:EGLN1) + + + + + + + pubmed:21861815 + + a(CHEBI:"iron chelator") decreases p(HGNC:EGLN3) + + + + + + + pubmed:21861815 + + a(CHEBI:"iron chelator") increases r(HGNC:HIF1A) + + + + + + + + + pubmed:21861815 + + composite(a(CHEBI:dioxygen), p(HGNC:HIF1AN)) increases p(HGNC:HIF1A, pmod(go:0018126 ! "protein hydroxylation", Asn, 803)) + + + + + + + + + pubmed:21861815 + + p(HGNC:HIF1A, pmod(go:0018126 ! "protein hydroxylation", Asn, 803)) decreases complex(p(HGNC:CREBBP), p(HGNC:HIF1A)) + + + + + + + pubmed:21861815 + + p(HGNC:HIF1A, pmod(go:0018126 ! "protein hydroxylation", Asn, 803)) decreases complex(p(HGNC:EP300), p(HGNC:HIF1A)) + + + + + + + pubmed:21861815 + + p(HGNC:HIF1A, pmod(go:0018126 ! "protein hydroxylation", Asn, 803)) decreases act(p(HGNC:CREBBP), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) + + + + + + + pubmed:21861815 + + p(HGNC:HIF1A, pmod(go:0018126 ! "protein hydroxylation", Asn, 803)) decreases act(p(HGNC:EP300), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) + + + + + + + pubmed:21861815 + + p(HGNC:NAA10) increases p(HGNC:HIF1A, pmod(go:0006473 ! "protein acetylation", Lys, 532)) + + + + + + + pubmed:21861815 + + p(HGNC:NAA10) increases complex(p(HGNC:HIF1A), p(HGNC:VHL)) + + + + + + + pubmed:21861815 + + p(HGNC:NAA10) increases deg(p(HGNC:HIF1A)) + + + + + + + pubmed:21861815 + + p(HGNC:HIF1A, pmod(go:0006473 ! "protein acetylation", Lys, 532)) increases complex(p(HGNC:HIF1A), p(HGNC:VHL)) + + + + + + + pubmed:21861815 + + p(HGNC:HIF1A, var("p.Lys532?")) increases p(HGNC:HIF1A) + + + + + + + pubmed:21861815 + + p(HGNC:HIF1A, pmod(go:0006468 ! "protein phosphorylation", Thr, 796)) increases complex(p(HGNC:ARNT), p(HGNC:HIF1A)) + + + + + + + pubmed:21861815 + + p(HGNC:HIF1A, pmod(go:0006468 ! "protein phosphorylation", Thr, 796)) increases complex(p(HGNC:CREBBP), p(HGNC:HIF1A)) + + + + + + + pubmed:21861815 + + p(HGNC:HIF1A, pmod(go:0006468 ! "protein phosphorylation", Thr, 796)) increases complex(p(HGNC:EP300), p(HGNC:HIF1A)) + + + + + + + pubmed:21861815 + + p(HGNC:HIF1A, pmod(go:0006468 ! "protein phosphorylation", Thr, 796)) decreases act(p(HGNC:HIF1AN)) + + + + + + + pubmed:21861815 + + p(HGNC:HIF1A, pmod(go:0006468 ! "protein phosphorylation", Thr, 796)) decreases p(HGNC:HIF1A, pmod(go:0018126 ! "protein hydroxylation", Asn, 803)) + + + + + + + pubmed:21861815 + + p(HGNC:HIF1A, pmod(go:0006468 ! "protein phosphorylation", Thr, 796)) increases act(p(HGNC:HIF1A), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) + + + + + + + pubmed:21861815 + + p(HGNC:HIF1A, pmod(go:0006468 ! "protein phosphorylation", Thr, 796)) increases tloc(p(HGNC:HIF1A), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) + + + + + + + pubmed:21861815 + + act(p(HGNC:HIF1A, pmod(go:0006468 ! "protein phosphorylation")), ma(GO:"proteasome binding")) increases deg(p(HGNC:HIF1A)) + + + + + + + pubmed:21861815 + + a(CHEBI:hydroxyl) decreases p(HGNC:HIF1A) + + + + + + + pubmed:21861815 + + p(HGNC:HIF1A, pmod(NCIT:C16944)) increases complex(a(NCIT:C13737), p(HGNC:HIF1A)) + + + + + + + pubmed:21861815 + + complex(a(NCIT:C13737), p(HGNC:HIF1A)) increases deg(p(HGNC:HIF1A)) + + + + + + + + + pubmed:21861815 + + p(HGNC:HIF1A, pmod(go:0017014 ! "protein nitrosylation")) increases p(HGNC:HIF1A) + + + + + + + pubmed:21861815 + + p(HGNC:HIF1A, pmod(go:0017014 ! "protein nitrosylation", Cys, 800)) increases complex(p(HGNC:CREBBP), p(HGNC:HIF1A)) + + + + + + + pubmed:21861815 + + p(HGNC:HIF1A, pmod(go:0017014 ! "protein nitrosylation", Cys, 800)) increases complex(p(HGNC:EP300), p(HGNC:HIF1A)) + + + + + + + pubmed:21861815 + + p(HGNC:HIF1A, pmod(go:0017014 ! "protein nitrosylation", Cys, 800)) increases act(p(HGNC:HIF1A)) + + + + + + + pubmed:21861815 + + p(HGNC:HIF1A, pmod(go:0016925 ! "protein sumoylation")) regulates r(HGNC:HIF1A) + + + + + + + pubmed:21861815 + + p(HGNC:HIF1A, pmod(go:0016925 ! "protein sumoylation")) regulates act(p(HGNC:HIF1A), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) + + + + + + + pubmed:21861815 + + p(HGNC:HIF1A, pmod(go:0016925 ! "protein sumoylation")) increases p(HGNC:HIF1A) + + + + + + + pubmed:21861815 + + act(p(HGNC:RWDD3)) increases act(p(HGNC:UBE2I)) + + + + + + + pubmed:21861815 + + p(HGNC:UBE2I) increases p(HGNC:HIF1A, pmod(go:0016925 ! "protein sumoylation")) + + + + + + + pubmed:19323834 + + p(HGNC:UBE2I) directlyDecreases r(HGNC:NOS2) + + + + + + + pubmed:18675254 + + p(HGNC:UBE2I) association complex(GO:"endoplasmic reticulum") + + + + + + + pubmed:21861815 + + p(HGNCGENEFAMILY:"SUMO specific peptidases") decreases p(HGNC:HIF1A, pmod(go:0016925 ! "protein sumoylation")) + + + + + + + pubmed:21861815 + + p(HGNCGENEFAMILY:"SUMO specific peptidases") regulates p(HGNC:HIF1A) + + + + + + + pubmed:21861815 + + path(DOID:hypoglycemia) negativeCorrelation bp(GO:"energy homeostasis") + + + + + + + pubmed:21861815 + + path(DOID:hypoglycemia) increases bp(GO:"neuron death") + + + + + + + pubmed:21861815 + + path(EFO:hypoxemia) negativeCorrelation p(HGNC:VEGFA) + + + + + + + pubmed:21861815 + + composite(p(HGNC:SOD1, var("Gly93Ala")), p(NCIT:C13718)) decreases bp(GO:"neuron death") + + + + + + + pubmed:21861815 + + composite(p(HGNC:SOD1, var("Gly93Ala")), p(NCIT:C13718)) decreases path(MESH:"Motor Disorders") + + + + + + + + + pubmed:21861815 + + p(HGNC:SOD1, var("Gly93Ala")) increases p(HGNC:EPO) + + + + + + + + + + + pubmed:21861815 + + complex(p(HGNC:NRP1), p(HGNC:VEGFA)) decreases bp(GO:"cell death") + + + + + + + + + pubmed:21861815 + + p(HGNC:NRP1) association bp(GO:"axon guidance") + + + + + + + pubmed:21861815 + + composite(p(HGNC:EPO), p(HGNC:SOD1, var("Gly93Ala"))) decreases path(DOID:"amyotrophic lateral sclerosis") + + + + + + + pubmed:21861815 + + composite(p(HGNC:EPO), p(HGNC:SOD1, var("Gly93Ala"))) decreases bp(GO:"neuron death") + + + + + + + pubmed:21861815 + + composite(p(HGNC:EPO), p(HGNC:SOD1, var("Gly93Ala"))) decreases bp(GO:"inflammatory response") + + + + + + + pubmed:21861815 + + a(PUBCHEM:6918822) positiveCorrelation p(MESH:"Hypoxia-Inducible Factor 1") + + + + + + + pubmed:21861815 + + a(PUBCHEM:6918822) decreases bp(GO:"neuron death in response to oxidative stress") + + + + + + + + + pubmed:21861815 + + a(PUBCHEM:6918822) increases r(HGNC:HIF1A) + + + + + + + pubmed:21861815 + + a(PUBCHEM:6918822) increases r(HGNC:EPO) + + + + + + + pubmed:21861815 + + a(PUBCHEM:6918822) increases r(HGNC:VEGFA) + + + + + + + pubmed:21861815 + + a(PUBCHEM:6918822) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:21861815 + + a(PUBCHEM:6918822) decreases path(MESH:"Amyloid Neuropathies") + + + + + + + + + pubmed:21861815 + + a(PUBCHEM:6918822) increases p(HGNC:ENO1) + + + + + + + pubmed:21861815 + + a(PUBCHEM:6918822) increases p(HGNC:VEGFA) + + + + + + + pubmed:21861815 + + a(PUBCHEM:6918822) increases p(HGNC:BDNF) + + + + + + + pubmed:21861815 + + composite(a(PUBCHEM:6918822), p(HGNC:SOD1, var("Gly93Ala"))) decreases path(DOID:"amyotrophic lateral sclerosis") + + + + + + + pubmed:21861815 + + a(PUBCHEM:2973) increases p(MESH:"Hypoxia-Inducible Factor 1") + + + + + + + pubmed:21861815 + + a(PUBCHEM:2973) increases act(p(MESH:"Hypoxia-Inducible Factor 1")) + + + + + + + pubmed:21861815 + + a(PUBCHEM:2973) decreases bp(GO:cognition) + + + + + + + pubmed:21861815 + + a(PUBCHEM:2973) decreases path(DOID:"Alzheimer's disease") + + + + + + + pubmed:21861815 + + a(PUBCHEM:2973) increases r(HGNC:TH) + + + + + + + pubmed:21861815 + + a(PUBCHEM:2973) decreases path(MESH:"Neurotoxicity Syndromes") + + + + + + + pubmed:21861815 + + a(PUBCHEM:2973) decreases path(DOID:"neurodegenerative disease") + + + + + + + pubmed:21861815 + + a(PUBCHEM:2973) negativeCorrelation path(NCIT:C27988) + + + + + + + pubmed:21861815 + + a(PUBCHEM:2973) decreases path(NCIT:C27988) + + + + + + + + + pubmed:30562574 + + bp(GO:"cellular response to oxidative stress") increases bp(GO:"chaperone-mediated autophagy") + + + + + + + pubmed:21861815 + + p(HGNC:SLC2A3) regulates bp(GO:"glucose import") + + + + + + + pubmed:21861815 + + a(CHEBI:"1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine") decreases p(HGNC:HIF1A) + + + + + + + pubmed:21861815 + + a(CHEBI:"1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine") increases bp(GO:"cell death") + + + + + + + pubmed:21861815 + + a(CHEBI:"1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine") increases path(MESH:"Neurotoxicity Syndromes") + + + + + + + pubmed:21861815 + + a(PUBCHEM:137275695) increases act(p(MESH:"Hypoxia-Inducible Factor 1")) + + + + + + + pubmed:21861815 + + a(PUBCHEM:137275695) increases a(CHEBI:dopamine, loc(GO:"extracellular region")) + + + + + + + pubmed:21861815 + + a(CHEBI:"cobalt dichloride") increases tloc(a(CHEBI:dopamine), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:21861815 + + a(CHEBI:"cobalt dichloride") increases p(MESH:"Hypoxia-Inducible Factor 1") + + + + + + + pubmed:21861815 + + a(CHEBI:"cobalt dichloride") negativeCorrelation path(NCIT:C27988) + + + + + + + pubmed:21861815 + + a(CHEBI:"cobalt dichloride") increases path(MESH:Cytoprotection) + + + + + + + pubmed:21861815 + + a(CHEBI:"3,4-dihydroxybenzoate") increases p(HGNC:HIF1A) + + + + + + + pubmed:21861815 + + a(CHEBI:"3,4-dihydroxybenzoate") increases g(HGNC:SLC40A1) + + + + + + + pubmed:21861815 + + a(CHEBI:"3,4-dihydroxybenzoate") increases g(HGNC:HMOX1) + + + + + + + pubmed:21861815 + + a(CHEBI:"3,4-dihydroxybenzoate") increases g(HGNC:SOD1) + + + + + + + pubmed:21861815 + + a(CHEBI:5-chloro-7-iodoquinolin-8-ol) increases p(HGNC:HIF1A) + + + + + + + pubmed:21861815 + + a(CHEBI:5-chloro-7-iodoquinolin-8-ol) decreases bp(GO:"cell death") + + + + + + + pubmed:21861815 + + a(CHEBI:5-chloro-7-iodoquinolin-8-ol) decreases a(CONSO:"huntingtin aggregates") + + + + + + + pubmed:21861815 + + a(CHEBI:5-chloro-7-iodoquinolin-8-ol) decreases path(HP:"Behavioral abnormality") + + + + + + + pubmed:21861815 + + a(CHEBI:5-chloro-7-iodoquinolin-8-ol) increases path(EFO:"physical activity") + + + + + + + pubmed:30116051 + + a(CHEBI:5-chloro-7-iodoquinolin-8-ol) increases bp(GO:macroautophagy) + + + + + + + pubmed:30116051 + + a(CHEBI:5-chloro-7-iodoquinolin-8-ol) decreases a(CHEBI:"amyloid-beta polypeptide 42") + + + + + + + pubmed:30116051 + + a(CHEBI:5-chloro-7-iodoquinolin-8-ol) decreases a(CONSO:"amyloid-beta aggregates") + + + + + + + pubmed:21861815 + + a(CHEBI:oxidopamine) increases path(DOID:"neurodegenerative disease") + + + + + + + pubmed:21722302 + + a(CHEBI:oxidopamine) increases path(MESH:"Parkinson Disease") + + + + + + + pubmed:21861815 + + path(NCIT:C27988) negativeCorrelation a(CHEBI:"cobalt dichloride") + + + + + + + pubmed:21861815 + + path(NCIT:C27988) negativeCorrelation a(CHEBI:L-mimosine) + + + + + + + pubmed:21861815 + + path(NCIT:C27988) negativeCorrelation a(PUBCHEM:2973) + + + + + + + pubmed:21861815 + + a(CHEBI:L-mimosine) negativeCorrelation path(NCIT:C27988) + + + + + + + pubmed:21861815 + + a(CHEBI:"3-nitropropanoic acid") increases path(NCIT:C27988) + + + + + + + pubmed:21861815 + + p(MESH:"Prolyl Hydroxylases") increases deg(p(HGNC:HIF1A)) + + + + + + + pubmed:21861815 + + p(MESH:"Prolyl Hydroxylases") increases path(DOID:"neurodegenerative disease") + + + + + + + pubmed:21861815 + + p(HGNC:ASPH) decreases act(p(HGNC:HIF1A)) + + + + + + + pubmed:21861815 + + p(HGNC:ASPH) increases path(DOID:"neurodegenerative disease") + + + + + + + pubmed:21861815 + + composite(a(CHEBI:"iron chelator"), a(CHEBI:"iron(2+)")) decreases a(CHEBI:hydroxyl) + + + + + + + pubmed:21861815 + + composite(a(CHEBI:"iron(2+)"), a(PUBCHEM:2973)) increases act(p(MESH:"Hypoxia-Inducible Factor 1")) + + + + + + + pubmed:21861815 + + composite(a(PUBCHEM:3052776), a(PUBCHEM:6918822)) decreases path(DOID:"Parkinson's disease") + + + + + + + + + + + pubmed:21861815 + + composite(a(PUBCHEM:3052776), a(PUBCHEM:6918819)) decreases path(DOID:"Parkinson's disease") + + + + + + + + + pubmed:21861815 + + a(PUBCHEM:6918819) increases p(HGNC:ENO1) + + + + + + + pubmed:21861815 + + a(PUBCHEM:6918819) increases p(HGNC:VEGFA) + + + + + + + pubmed:21861815 + + a(PUBCHEM:6918819) increases p(HGNC:BDNF) + + + + + + + pubmed:28148553 + + p(HGNC:EIF2AK3, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation a(CHEBI:thapsigargin) + + + + + + + pubmed:21722302 + + p(HGNC:EIF2AK3, pmod(go:0006468 ! "protein phosphorylation")) increases bp(CONSO:"protein aggregation") + + + + + + + pubmed:30740335 + + p(HGNC:EIF2AK3, pmod(go:0006468 ! "protein phosphorylation")) increases p(HGNC:ATF4) + + + + + + + + + pubmed:28148553 + + p(HGNC:EIF2AK3) association p(HGNC:NFE2L2) + + + + + + + pubmed:28148553 + + p(HGNC:EIF2AK3) decreases p(CONSO:"4R tau") + + + + + + + pubmed:28148553 + + p(HGNC:EIF2AK3) decreases composite(a(PUBCHEM:3108148), p(CONSO:"4R tau")) + + + + + + + + + pubmed:21722302 + + act(p(HGNC:EIF2AK3)) association bp(MESH:"Unfolded Protein Response") + + + + + + + pubmed:21722302 + + p(HGNC:EIF2AK3) increases p(HGNC:EIF2A, pmod(go:0006468 ! "protein phosphorylation", Ser, 51)) + + + + + + + pubmed:21722302 + + p(HGNC:EIF2AK3) decreases complex(p(HGNC:KEAP1), p(HGNC:NFE2L2)) + + + + + + + pubmed:21722302 + + p(HGNC:EIF2AK3) increases p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation"), loc(MESH:"Cell Nucleus")) + + + + + + + pubmed:21722302 + + p(HGNC:EIF2AK3) regulates bp(GO:autophagy) + + + + + + + pubmed:21722302 + + p(HGNC:EIF2AK3) increases bp(GO:autophagy) + + + + + + + pubmed:21722302 + + p(HGNC:EIF2AK3) increases p(HGNC:ATG12) + + + + + + + pubmed:21722302 + + p(HGNC:EIF2AK3) increases p(HGNC:DDIT3) + + + + + + + pubmed:21722302 + + p(HGNC:EIF2AK3) increases p(HGNC:ATF4) + + + + + + + pubmed:21722302 + + p(HGNC:EIF2AK3) association p(PFAM:Presenilin) + + + + + + + pubmed:30606258 + + act(p(HGNC:EIF2AK3)) increases bp(GO:"PERK-mediated unfolded protein response") + + + + + + + pubmed:30606258 + + act(p(HGNC:EIF2AK3)) increases p(HGNC:EIF2S1, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:30740335 + + p(HGNC:EIF2AK3) increases p(HGNC:EIF2S1, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:30740335 + + act(p(HGNC:EIF2AK3)) increases p(HGNC:EIF2S1, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:30740335 + + p(HGNC:EIF2AK3) increases p(HGNC:EIF2S1, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:30740335 + + p(HGNC:EIF2AK3) increases p(HGNC:EIF2S1, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:25784053 + + act(p(HGNC:EIF2AK3)) increases p(HGNC:EIF2S1, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:30740335 + + p(HGNC:EIF2AK3) regulates path(MESH:"Unfolded Protein Response") + + + + + + + pubmed:30740335 + + p(HGNC:EIF2AK3) decreases bp(GO:"synaptic signaling") + + + + + + + pubmed:30740335 + + p(HGNC:EIF2AK3) association bp(GO:"negative regulation of dopamine receptor signaling pathway") + + + + + + + pubmed:27299292 + + p(HGNC:EIF2AK3) association bp(GO:"response to endoplasmic reticulum stress") + + + + + + + pubmed:27299292 + + p(HGNC:EIF2AK3) association act(p(HGNC:TFEB)) + + + + + + + pubmed:27299292 + + p(HGNC:EIF2AK3) association p(HGNC:PPP3CA) + + + + + + + + + + + pubmed:21722302 + + p(HGNC:EIF2A) increases p(HGNC:NUPR1) + + + + + + + pubmed:21722302 + + p(HGNC:EIF2A) increases p(HGNC:ATF4) + + + + + + + pubmed:21722302 + + p(HGNC:EIF2A) increases p(HGNC:DDIT3) + + + + + + + pubmed:21722302 + + p(HGNC:EIF2A) increases p(HGNC:TRIB3) + + + + + + + pubmed:24563850 + + p(HGNC:EIF2A) association p(HGNC:HSPB8) + + + + + + + pubmed:28148553 + + p(HGNC:EIF2A, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation a(CHEBI:thapsigargin) + + + + + + + pubmed:21722302 + + p(HGNC:EIF2A, pmod(go:0006468 ! "protein phosphorylation")) increases bp(CONSO:"protein aggregation") + + + + + + + + + pubmed:27181519 + + p(HGNC:EIF2A, pmod(go:0006468 ! "protein phosphorylation")) increases complex(GO:"cytoplasmic stress granule") + + + + + + + pubmed:27181519 + + p(HGNC:EIF2A, pmod(go:0006468 ! "protein phosphorylation")) decreases bp(GO:translation) + + + + + + + pubmed:28148553 + + bp(MESH:"Unfolded Protein Response") association p(HGNC:MAPT) + + + + + + + pubmed:21722302 + + bp(MESH:"Unfolded Protein Response") decreases bp(GO:translation) + + + + + + + pubmed:21722302 + + bp(MESH:"Unfolded Protein Response") decreases bp(GO:"mRNA transcription") + + + + + + + pubmed:21722302 + + bp(MESH:"Unfolded Protein Response") increases p(MESH:"Molecular Chaperones") + + + + + + + pubmed:21722302 + + bp(MESH:"Unfolded Protein Response") increases deg(p(MESH:Proteins, pmod(CONSO:misfolded))) + + + + + + + pubmed:21722302 + + bp(MESH:"Unfolded Protein Response") association act(p(HGNC:ERN1)) + + + + + + + pubmed:21722302 + + bp(MESH:"Unfolded Protein Response") association act(p(HGNC:EIF2AK3)) + + + + + + + pubmed:21722302 + + bp(MESH:"Unfolded Protein Response") association act(p(HGNC:ATF6)) + + + + + + + pubmed:21722302 + + bp(MESH:"Unfolded Protein Response") increases act(p(HGNC:ATF6)) + + + + + + + pubmed:21722302 + + bp(MESH:"Unfolded Protein Response") increases act(p(HGNC:ATF4)) + + + + + + + pubmed:21722302 + + bp(MESH:"Unfolded Protein Response") increases act(p(HGNC:ATF3)) + + + + + + + pubmed:21722302 + + bp(MESH:"Unfolded Protein Response") increases act(p(HGNC:NFE2L2)) + + + + + + + pubmed:21722302 + + bp(MESH:"Unfolded Protein Response") increases act(p(HGNC:XBP1)) + + + + + + + pubmed:21722302 + + bp(MESH:"Unfolded Protein Response") increases bp(GO:"apoptotic signaling pathway") + + + + + + + pubmed:21722302 + + bp(MESH:"Unfolded Protein Response") increases p(HGNC:DDIT3) + + + + + + + pubmed:21722302 + + bp(MESH:"Unfolded Protein Response") increases p(HGNC:DDIT3) + + + + + + + pubmed:21722302 + + bp(MESH:"Unfolded Protein Response") increases bp(GO:autophagy) + + + + + + + pubmed:21722302 + + bp(MESH:"Unfolded Protein Response") increases bp(GO:autophagy) + + + + + + + pubmed:21722302 + + bp(MESH:"Unfolded Protein Response") increases p(HGNC:HSPA5) + + + + + + + pubmed:21722302 + + bp(MESH:"Unfolded Protein Response") increases p(HGNC:EIF2A, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:21722302 + + bp(MESH:"Unfolded Protein Response") increases bp(MESH:Apoptosis) + + + + + + + pubmed:21722302 + + bp(MESH:"Unfolded Protein Response") increases bp(MESH:Apoptosis) + + + + + + + pubmed:21722302 + + bp(MESH:"Unfolded Protein Response") increases bp(MESH:Apoptosis) + + + + + + + pubmed:21722302 + + bp(MESH:"Unfolded Protein Response") increases bp(GO:mitophagy) + + + + + + + pubmed:21722302 + + bp(MESH:"Unfolded Protein Response") association p(HGNC:VAPB) + + + + + + + pubmed:21722302 + + bp(MESH:"Unfolded Protein Response") association path(MESH:"Neurodegenerative Diseases") + + + + + + + pubmed:30740335 + + bp(MESH:"Unfolded Protein Response") increases deg(p(MESH:"Mutant Proteins")) + + + + + + + pubmed:28148553 + + a(PUBCHEM:354398) association path(DOID:tauopathy) + + + + + + + pubmed:28148553 + + a(PUBCHEM:354398) increases p(HGNC:MAPT) + + + + + + + pubmed:28148553 + + a(PUBCHEM:354398) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:28148553 + + a(PUBCHEM:354398) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation), loc(GO:"somatodendritic compartment")) + + + + + + + pubmed:28148553 + + a(PUBCHEM:354398) increases bp(GO:"cell death") + + + + + + + pubmed:28148553 + + a(PUBCHEM:354398) increases act(p(HGNCGENEFAMILY:"Mitochondrial complex I assembly complex")) + + + + + + + pubmed:28148553 + + a(PUBCHEM:354398) increases p(HGNC:EIF2AK3, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:28148553 + + a(PUBCHEM:354398) decreases p(HGNC:EIF2AK3) + + + + + + + pubmed:28148553 + + a(PUBCHEM:354398) decreases p(HGNC:EIF2A) + + + + + + + + + + + pubmed:28148553 + + a(PUBCHEM:354398) decreases a(CHEBI:"3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide") + + + + + + + pubmed:28148553 + + a(PUBCHEM:354398) decreases a(CHEBI:ATP) + + + + + + + + + pubmed:28148553 + + a(PUBCHEM:354398) increases a(CONSO:"Tau antibody, MC1") + + + + + + + pubmed:28148553 + + a(PUBCHEM:354398) increases p(CONSO:"Tau epitope, CP13") + + + + + + + pubmed:28148553 + + a(PUBCHEM:354398) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) + + + + + + + pubmed:28148553 + + a(PUBCHEM:354398) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) + + + + + + + pubmed:28148553 + + a(PUBCHEM:354398) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + + + + + + + pubmed:28148553 + + a(PUBCHEM:354398) increases p(CONSO:"Tau epitope, AD2") + + + + + + + pubmed:28148553 + + a(PUBCHEM:354398) causesNoChange a(CONSO:"Tau antibody, HT7") + + + + + + + pubmed:28148553 + + a(PUBCHEM:354398) increases p(CONSO:"4R tau") + + + + + + + pubmed:28148553 + + a(PUBCHEM:354398) causesNoChange p(CONSO:"3R tau") + + + + + + + pubmed:28148553 + + a(PUBCHEM:354398) increases r(HGNC:SRSF2) + + + + + + + pubmed:28148553 + + a(PUBCHEM:354398) decreases p(HGNC:NEFM, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:28148553 + + a(PUBCHEM:354398) increases path(DOID:"axonal neuropathy") + + + + + + + pubmed:26631930 + + a(PUBCHEM:354398) decreases act(complex(GO:"mitochondrial respiratory chain complex I")) + + + + + + + pubmed:28148553 + + act(p(HGNCGENEFAMILY:"Mitochondrial complex I assembly complex")) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation), loc(GO:"somatodendritic compartment")) + + + + + + + pubmed:28148553 + + p(UNIPROT:"X5DSL3 (X5DSL3_ANAMA)") causesNoChange p(HGNC:EIF2AK3) + + + + + + + pubmed:28148553 + + p(UNIPROT:"X5DSL3 (X5DSL3_ANAMA)") causesNoChange p(HGNC:EIF2AK3, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:28148553 + + p(UNIPROT:"X5DSL3 (X5DSL3_ANAMA)") causesNoChange p(HGNC:EIF2A) + + + + + + + pubmed:28148553 + + a(PUBCHEM:3108148) increases p(HGNC:EIF2AK3) + + + + + + + + + + + + + + + + + pubmed:28148553 + + a(PUBCHEM:3108148) decreases composite(a(PUBCHEM:354398), p(CONSO:"4R tau")) + + + + + + + pubmed:28148553 + + a(PUBCHEM:3108148) increases bp(GO:"chromatin organization") + + + + + + + pubmed:28148553 + + a(PUBCHEM:3108148) decreases path(MESH:"Neuronal Plasticity") + + + + + + + pubmed:28148553 + + a(PUBCHEM:3108148) increases r(HGNC:HMOX1) + + + + + + + + + pubmed:28148553 + + a(PUBCHEM:3108148) increases composite(a(PUBCHEM:3108148), p(HGNC:NFE2L2)) + + + + + + + pubmed:28148553 + + a(PUBCHEM:3108148) decreases a(CONSO:"Tau antibody, MC1") + + + + + + + pubmed:28148553 + + a(PUBCHEM:3108148) decreases p(CONSO:"Tau epitope, CP13") + + + + + + + pubmed:28148553 + + a(PUBCHEM:3108148) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) + + + + + + + pubmed:28148553 + + a(PUBCHEM:3108148) decreases p(CONSO:"Tau epitope, AD2") + + + + + + + pubmed:28148553 + + a(PUBCHEM:3108148) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) + + + + + + + pubmed:28148553 + + a(PUBCHEM:3108148) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + + + + + + + pubmed:28148553 + + a(PUBCHEM:3108148) causesNoChange a(CONSO:"Tau antibody, HT7") + + + + + + + pubmed:28148553 + + a(PUBCHEM:3108148) decreases p(CONSO:"4R tau") + + + + + + + pubmed:28148553 + + a(PUBCHEM:3108148) directlyDecreases r(HGNC:SRSF2) + + + + + + + + + pubmed:28148553 + + a(PUBCHEM:3108148) increases p(HGNC:NEFM, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:28148553 + + a(PUBCHEM:3108148) decreases path(DOID:"axonal neuropathy") + + + + + + + + + + + pubmed:28148553 + + composite(a(PUBCHEM:3108148), a(PUBCHEM:354398)) increases p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:28148553 + + composite(a(PUBCHEM:3108148), a(PUBCHEM:354398)) causesNoChange p(HGNC:EIF2A, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:28148553 + + composite(a(PUBCHEM:3108148), a(PUBCHEM:354398)) increases a(CHEBI:"3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide") + + + + + + + pubmed:28148553 + + composite(a(PUBCHEM:3108148), a(PUBCHEM:354398)) increases a(CHEBI:ATP) + + + + + + + pubmed:28148553 + + composite(a(PUBCHEM:3108148), a(PUBCHEM:354398)) increases bp(GO:"metabolic process") + + + + + + + pubmed:28148553 + + a(PUBCHEM:53469448) decreases p(HGNC:EIF2AK3) + + + + + + + + + + + + + + + pubmed:28148553 + + composite(a(PUBCHEM:354398), a(PUBCHEM:53469448)) decreases p(HGNC:EIF2A, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:28148553 + + composite(a(PUBCHEM:354398), a(PUBCHEM:53469448)) causesNoChange a(CHEBI:"3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide") + + + + + + + pubmed:28148553 + + composite(a(PUBCHEM:354398), a(PUBCHEM:53469448)) increases a(CHEBI:ATP) + + + + + + + pubmed:28148553 + + composite(a(PUBCHEM:3108148), p(CONSO:"4R tau")) increases p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:28148553 + + composite(a(PUBCHEM:3108148), p(CONSO:"4R tau")) causesNoChange p(HGNC:EIF2A, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:28148553 + + composite(a(PUBCHEM:53469448), p(CONSO:"4R tau")) decreases p(HGNC:EIF2A, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:28148553 + + composite(a(PUBCHEM:53469448), p(CONSO:"4R tau")) causesNoChange p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:28148553 + + composite(a(PUBCHEM:3108148), p(CONSO:"3R tau")) causesNoChange p(HGNC:EIF2A, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:28148553 + + composite(a(PUBCHEM:3108148), p(CONSO:"3R tau")) causesNoChange p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:28148553 + + composite(a(PUBCHEM:53469448), p(CONSO:"3R tau")) causesNoChange p(HGNC:EIF2A, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:28148553 + + composite(a(PUBCHEM:53469448), p(CONSO:"3R tau")) causesNoChange p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:28148553 + + a(CHEBI:"3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide") association bp(GO:"metabolic process") + + + + + + + + + pubmed:28148553 + + composite(a(CHEBI:"3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide"), a(PUBCHEM:3108148)) decreases path(CONSO:"4R tauopathy") + + + + + + + pubmed:28148553 + + composite(a(CHEBI:ATP), a(PUBCHEM:3108148)) decreases path(CONSO:"4R tauopathy") + + + + + + + pubmed:28148553 + + composite(a(CHEBI:ATP), a(PUBCHEM:53469448)) decreases path(CONSO:"4R tauopathy") + + + + + + + pubmed:28148553 + + composite(a(PUBCHEM:354398), p(CONSO:"4R tau")) negativeCorrelation bp(GO:"chromatin organization") + + + + + + + pubmed:28148553 + + composite(a(PUBCHEM:354398), p(CONSO:"4R tau")) increases path(MESH:"Neuronal Plasticity") + + + + + + + pubmed:28148553 + + bp(GO:"chromatin organization") negativeCorrelation composite(a(PUBCHEM:354398), p(CONSO:"4R tau")) + + + + + + + pubmed:28148553 + + a(PUBCHEM:71772353) increases p(HGNC:NFE2L2) + + + + + + + pubmed:28148553 + + a(PUBCHEM:71772353) decreases path(CONSO:"4R tauopathy") + + + + + + + pubmed:25331948 + + p(CONSO:"Tau epitope, CP13") equivalentTo p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) + + + + + + + pubmed:28148553 + + composite(a(PUBCHEM:3108148), p(CONSO:"Tau isoform F (441 aa)")) decreases p(CONSO:"Tau epitope, CP13") + + + + + + + pubmed:28148553 + + composite(a(PUBCHEM:3108148), p(CONSO:"Tau isoform F (441 aa)")) causesNoChange p(CONSO:"Tau epitope, AD2") + + + + + + + pubmed:28148553 + + composite(a(PUBCHEM:3108148), p(CONSO:"Tau isoform F (441 aa)")) causesNoChange a(CONSO:"Tau antibody, HT7") + + + + + + + pubmed:28148553 + + p(HGNC:NEFM, pmod(go:0006468 ! "protein phosphorylation")) regulates act(a(MESH:Axons)) + + + + + + + pubmed:28148553 + + p(HGNC:NEFM, pmod(go:0006468 ! "protein phosphorylation")) decreases path(DOID:"axonal neuropathy") + + + + + + + + + pubmed:28148553 + + path(MESH:"Protein Conformation") negativeCorrelation p(HGNC:MAPT, var("p.Pro301Ser")) + + + + + + + pubmed:23384725 + + path(MESH:"Protein Conformation") negativeCorrelation p(HGNC:TARDBP, frag("101_191"), pmod(GO:"protein oxidation", Cys, 173)) + + + + + + + pubmed:23384725 + + path(MESH:"Protein Conformation") association p(HGNC:TARDBP, frag("101_191"), pmod(GO:"protein oxidation", Cys, 175)) + + + + + + + pubmed:28148553 + + bp(GO:"dendritic spine maintenance") negativeCorrelation p(HGNC:MAPT, var("p.Pro301Ser")) + + + + + + + pubmed:28148553 + + path(MESH:Locomotion) negativeCorrelation p(HGNC:MAPT, var("p.Pro301Ser")) + + + + + + + pubmed:28148553 + + a(FMA:83664) negativeCorrelation p(HGNC:MAPT, var("p.Pro301Ser")) + + + + + + + pubmed:28148553 + + composite(a(PUBCHEM:3108148), p(HGNC:MAPT, var("p.Pro301Ser"))) increases p(HGNC:EIF2AK3, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:28148553 + + composite(a(PUBCHEM:3108148), p(HGNC:MAPT, var("p.Pro301Ser"))) increases p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:28148553 + + composite(a(PUBCHEM:3108148), p(HGNC:MAPT, var("p.Pro301Ser"))) decreases a(CONSO:"Tau antibody, HT7") + + + + + + + pubmed:28148553 + + composite(a(PUBCHEM:3108148), p(HGNC:MAPT, var("p.Pro301Ser"))) decreases a(CONSO:"Tau antibody, MC1") + + + + + + + pubmed:28148553 + + composite(a(PUBCHEM:3108148), p(HGNC:MAPT, var("p.Pro301Ser"))) decreases p(CONSO:"Tau epitope, CP13") + + + + + + + pubmed:28148553 + + composite(a(PUBCHEM:3108148), p(HGNC:MAPT, var("p.Pro301Ser"))) decreases p(CONSO:"Tau epitope, AT180") + + + + + + + pubmed:28148553 + + composite(a(PUBCHEM:3108148), p(HGNC:MAPT, var("p.Pro301Ser"))) increases bp(GO:"learning or memory") + + + + + + + pubmed:28148553 + + composite(a(PUBCHEM:3108148), p(HGNC:MAPT, var("p.Pro301Ser"))) increases bp(GO:"dendritic spine maintenance") + + + + + + + pubmed:28148553 + + composite(a(PUBCHEM:3108148), p(HGNC:MAPT, var("p.Pro301Ser"))) increases a(OMIT:0023601) + + + + + + + pubmed:28148553 + + composite(a(PUBCHEM:3108148), p(HGNC:MAPT, var("p.Pro301Ser"))) positiveCorrelation a(MESH:"Spinal Cord Ventral Horn") + + + + + + + pubmed:22833681 + + p(CONSO:"Tau epitope, AT180") equivalentTo p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) + + + + + + + pubmed:28148553 + + composite(a(PUBCHEM:5234), p(HGNC:MAPT)) increases bp(GO:"learning or memory") + + + + + + + pubmed:28148553 + + composite(a(PUBCHEM:5234), p(HGNC:MAPT)) increases a(OMIT:0023601) + + + + + + + + + + + pubmed:28148553 + + composite(a(PUBCHEM:3108148), p(HGNC:MAPT)) causesNoChange bp(GO:"dendritic spine maintenance") + + + + + + + pubmed:28148553 + + composite(a(PUBCHEM:5234), p(HGNC:MAPT, var("p.Pro301Ser"))) decreases a(OMIT:0023601) + + + + + + + pubmed:28148553 + + a(MESH:"Spinal Cord Ventral Horn") negativeCorrelation p(HGNC:MAPT, var("p.Pro301Ser")) + + + + + + + pubmed:28148553 + + a(MESH:"Spinal Cord Ventral Horn") positiveCorrelation composite(a(PUBCHEM:3108148), p(HGNC:MAPT, var("p.Pro301Ser"))) + + + + + + + pubmed:21722302 + + path(MESH:"Prion Diseases") association path(CONSO:Neurodegeneration) + + + + + + + pubmed:30740335 + + path(MESH:"Prion Diseases") increases p(HGNC:EIF2AK3) + + + + + + + pubmed:30740335 + + path(MESH:"Prion Diseases") increases path(MESH:"Unfolded Protein Response") + + + + + + + pubmed:14556719 + + path(MESH:"Prion Diseases") increases path(MESH:"Motor Disorders") + + + + + + + pubmed:14556719 + + path(MESH:"Prion Diseases") increases path(MESH:Dementia) + + + + + + + pubmed:14556719 + + path(MESH:"Prion Diseases") increases path(MESH:Death) + + + + + + + pubmed:14556719 + + path(MESH:"Prion Diseases") increases bp(GO:"neuron death") + + + + + + + pubmed:14556719 + + path(MESH:"Prion Diseases") increases path(MESH:Gliosis) + + + + + + + pubmed:14556719 + + path(MESH:"Prion Diseases") increases a(CONSO:"amyloid-beta aggregates") + + + + + + + pubmed:14556719 + + path(MESH:"Prion Diseases") negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + + + + + + + pubmed:14556719 + + path(MESH:"Prion Diseases") negativeCorrelation bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + + + + + + + pubmed:29980653 + + path(MESH:"Prion Diseases") isA path(MESH:"Neurodegenerative Diseases") + + + + + + + pubmed:29980653 + + path(MESH:"Prion Diseases") positiveCorrelation p(HGNC:PRNP, var("?")) + + + + + + + pubmed:21722302 + + bp(MESH:"Endoplasmic Reticulum Stress") increases path(CONSO:Neurodegeneration) + + + + + + + pubmed:21722302 + + bp(MESH:"Endoplasmic Reticulum Stress") association p(MESH:Proteins, pmod(CONSO:misfolded)) + + + + + + + pubmed:21722302 + + bp(MESH:"Endoplasmic Reticulum Stress") increases bp(MESH:"Unfolded Protein Response") + + + + + + + pubmed:21722302 + + bp(MESH:"Endoplasmic Reticulum Stress") increases p(HGNC:ERN1) + + + + + + + pubmed:21722302 + + bp(MESH:"Endoplasmic Reticulum Stress") increases p(HGNC:EIF2AK3) + + + + + + + pubmed:25784053 + + bp(MESH:"Endoplasmic Reticulum Stress") increases p(HGNC:EIF2AK3) + + + + + + + pubmed:21722302 + + bp(MESH:"Endoplasmic Reticulum Stress") increases p(HGNC:ATF6) + + + + + + + pubmed:21722302 + + bp(MESH:"Endoplasmic Reticulum Stress") increases tloc(p(HGNC:ATF6), fromLoc(GO:"endoplasmic reticulum membrane"), toLoc(GO:"Golgi apparatus")) + + + + + + + pubmed:25784053 + + bp(MESH:"Endoplasmic Reticulum Stress") increases tloc(p(HGNC:ATF6), fromLoc(MESH:"Endoplasmic Reticulum"), toLoc(MESH:"Golgi Apparatus")) + + + + + + + pubmed:21722302 + + bp(MESH:"Endoplasmic Reticulum Stress") increases p(HGNC:ERN1, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:21722302 + + bp(MESH:"Endoplasmic Reticulum Stress") decreases complex(p(HGNC:ATF6), p(HGNC:HSPA5)) + + + + + + + pubmed:21722302 + + bp(MESH:"Endoplasmic Reticulum Stress") increases p(HGNC:CASP4) + + + + + + + pubmed:21722302 + + bp(MESH:"Endoplasmic Reticulum Stress") increases p(HGNC:CASP2) + + + + + + + pubmed:21722302 + + bp(MESH:"Endoplasmic Reticulum Stress") association p(HGNC:BCL2) + + + + + + + pubmed:21722302 + + bp(MESH:"Endoplasmic Reticulum Stress") decreases p(HGNC:BCL2) + + + + + + + pubmed:21722302 + + bp(MESH:"Endoplasmic Reticulum Stress") increases complex(GO:"BIM-BCL-2 complex") + + + + + + + pubmed:21722302 + + bp(MESH:"Endoplasmic Reticulum Stress") increases complex(GO:"PUMA-BCL-2 complex") + + + + + + + pubmed:21722302 + + bp(MESH:"Endoplasmic Reticulum Stress") increases complex(GO:"NOXA-BCL-2 complex") + + + + + + + pubmed:21722302 + + bp(MESH:"Endoplasmic Reticulum Stress") increases p(HGNC:DDIT3) + + + + + + + pubmed:21722302 + + bp(MESH:"Endoplasmic Reticulum Stress") increases act(p(HGNC:PRKAA1)) + + + + + + + pubmed:21722302 + + bp(MESH:"Endoplasmic Reticulum Stress") increases tloc(a(CHEBI:"calcium cation"), fromLoc(GO:"endoplasmic reticulum"), toLoc(GO:cytoplasm)) + + + + + + + pubmed:21722302 + + bp(MESH:"Endoplasmic Reticulum Stress") increases bp(GO:autophagy) + + + + + + + pubmed:21722302 + + bp(MESH:"Endoplasmic Reticulum Stress") association path(MESH:"Neurodegenerative Diseases") + + + + + + + pubmed:21722302 + + bp(MESH:"Endoplasmic Reticulum Stress") decreases r(HGNC:HSPA5) + + + + + + + pubmed:21722302 + + bp(MESH:"Endoplasmic Reticulum Stress") increases p(HGNC:ATF4) + + + + + + + pubmed:21722302 + + p(MESH:"Molecular Chaperones") increases bp(GO:"protein folding") + + + + + + + pubmed:21722302 + + p(MESH:"Molecular Chaperones") increases bp(GO:"protein folding") + + + + + + + + + pubmed:25784053 + + bp(GO:"protein folding") association bp(CONSO:Proteostasis) + + + + + + + pubmed:29311797 + + bp(GO:"protein folding") association a(MESH:"Molecular Chaperones") + + + + + + + + + pubmed:21722302 + + act(p(HGNC:ERN1)) association bp(MESH:"Unfolded Protein Response") + + + + + + + + + pubmed:25784053 + + act(p(HGNC:ERN1), ma(go:0016301 ! "kinase activity")) increases p(HGNC:ERN1, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + + + + + pubmed:21722302 + + p(HGNC:ERN1) regulates bp(GO:autophagy) + + + + + + + pubmed:21722302 + + p(HGNC:ERN1) increases bp(GO:"JNK cascade") + + + + + + + pubmed:21722302 + + p(HGNC:ERN1) association p(PFAM:Presenilin) + + + + + + + pubmed:21722302 + + p(HGNC:ERN1) regulates p(HGNC:XBP1) + + + + + + + pubmed:25784053 + + act(p(HGNC:ERN1), ma(GO:"ribonuclease activity")) increases p(HGNC:XBP1) + + + + + + + pubmed:21722302 + + p(HGNC:ERN1) association p(HGNC:VAPB) + + + + + + + pubmed:30606258 + + act(p(HGNC:ERN1)) increases bp(GO:"IRE1-mediated unfolded protein response") + + + + + + + pubmed:30740335 + + p(HGNC:ERN1) regulates path(MESH:"Unfolded Protein Response") + + + + + + + pubmed:30740335 + + p(HGNC:ERN1) increases p(HGNC:XBP1, frag("?")) + + + + + + + pubmed:30740335 + + p(HGNC:ERN1) increases p(HGNC:XBP1, frag("?")) + + + + + + + + + pubmed:30740335 + + p(HGNC:ERN1) increases deg(p(HGNC:HTT, pmod(HBP:misfolded))) + + + + + + + + + pubmed:21722302 + + act(p(HGNC:ATF6)) association bp(MESH:"Unfolded Protein Response") + + + + + + + pubmed:21722302 + + p(HGNC:ATF6) increases a(MESH:"Molecular Chaperones") + + + + + + + pubmed:21722302 + + p(HGNC:ATF6) increases a(MESH:"Molecular Chaperones") + + + + + + + pubmed:21722302 + + p(HGNC:ATF6) increases bp(GO:"ERAD pathway") + + + + + + + pubmed:30740335 + + p(HGNC:ATF6) association bp(GO:"ERAD pathway") + + + + + + + pubmed:21722302 + + p(HGNC:ATF6) association p(HGNC:VAPB) + + + + + + + + + pubmed:21722302 + + act(p(HGNC:ATF6)) increases r(HGNC:XBP1) + + + + + + + pubmed:30740335 + + p(HGNC:ATF6) increases r(HGNC:XBP1) + + + + + + + + + + + pubmed:30740335 + + p(HGNC:ATF6) regulates path(MESH:"Unfolded Protein Response") + + + + + + + pubmed:30740335 + + act(p(HGNC:ATF6)) increases tloc(p(HGNC:ATF6), fromLoc(GO:"endoplasmic reticulum"), toLoc(GO:"Golgi apparatus")) + + + + + + + pubmed:30740335 + + p(HGNC:ATF6) increases p(HGNC:XBP1) + + + + + + + pubmed:30740335 + + p(HGNC:ATF6) increases p(HGNC:HSPA5) + + + + + + + pubmed:30740335 + + p(HGNC:ATF6) increases path(MESH:Organogenesis) + + + + + + + pubmed:30740335 + + p(HGNC:ATF6) increases bp(GO:"mitochondrial unfolded protein response") + + + + + + + pubmed:25784053 + + p(HGNC:ATF6) negativeCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:25784053 + + p(HGNC:ATF6) negativeCorrelation path(MESH:"Huntington Disease") + + + + + + + pubmed:21722302 + + complex(p(HGNC:ERN1), p(HGNC:HSPA5)) decreases act(p(HGNC:ERN1)) + + + + + + + pubmed:21722302 + + complex(p(HGNC:EIF2AK3), p(HGNC:HSPA5)) decreases act(p(HGNC:EIF2AK3)) + + + + + + + pubmed:21722302 + + complex(p(HGNC:ATF6), p(HGNC:HSPA5)) decreases act(p(HGNC:ATF6)) + + + + + + + pubmed:21722302 + + p(HGNC:ERN1, pmod(go:0006468 ! "protein phosphorylation")) increases act(p(HGNC:ERN1), ma(MESH:Ribonucleases)) + + + + + + + pubmed:30606258 + + p(HGNC:ERN1, pmod(go:0006468 ! "protein phosphorylation")) increases act(p(HGNC:ERN1)) + + + + + + + pubmed:25784053 + + p(HGNC:ERN1, pmod(go:0006468 ! "protein phosphorylation")) increases act(p(HGNC:ERN1), ma(GO:"ribonuclease activity")) + + + + + + + pubmed:30740335 + + act(p(HGNC:ERN1, pmod(go:0006468 ! "protein phosphorylation"))) increases bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") + + + + + + + pubmed:21722302 + + complex(p(HGNC:ERN1), p(HGNC:TRAF2)) increases p(HGNC:MAP3K5) + + + + + + + + + pubmed:21722302 + + p(HGNC:BAK1) increases act(p(HGNC:ERN1), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:21722302 + + p(HGNC:BAK1) increases act(p(HGNC:ERN1), ma(MESH:Endoribonucleases)) + + + + + + + pubmed:21722302 + + p(HGNC:BAK1) association bp(MESH:Apoptosis) + + + + + + + pubmed:21722302 + + p(HGNC:BAK1) increases bp(GO:"mitochondrial outer membrane permeabilization") + + + + + + + pubmed:21722302 + + p(HGNC:BAK1) increases complex(GO:"mitochondrial permeability transition pore complex") + + + + + + + pubmed:21722302 + + p(HGNC:DAB2IP) increases act(p(HGNC:ERN1)) + + + + + + + pubmed:21722302 + + composite(p(HGNC:ERN1), p(MESH:"HSP72 Heat-Shock Proteins")) increases p(HGNC:XBP1) + + + + + + + + + pubmed:21722302 + + p(HGNC:XBP1) decreases bp(MESH:Apoptosis) + + + + + + + pubmed:21722302 + + p(HGNC:XBP1) increases a(MESH:"Molecular Chaperones") + + + + + + + pubmed:21722302 + + p(HGNC:XBP1) decreases bp(GO:autophagy) + + + + + + + pubmed:30740335 + + p(HGNC:XBP1) decreases bp(GO:autophagy) + + + + + + + pubmed:21722302 + + p(HGNC:XBP1) increases p(HGNC:SOD1, pmod(MESH:"Mutant Proteins")) + + + + + + + pubmed:21722302 + + p(HGNC:XBP1) regulates g(FPLX:"Gamma_secretase") + + + + + + + pubmed:21722302 + + p(HGNC:XBP1) regulates p(HGNC:APP) + + + + + + + pubmed:21722302 + + p(HGNC:XBP1) association path(MESH:"Alzheimer Disease") + + + + + + + pubmed:21722302 + + p(HGNC:XBP1) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:21722302 + + p(HGNC:XBP1) association a(CHEBI:amyloid-beta) + + + + + + + pubmed:21722302 + + p(HGNC:XBP1) association p(HGNC:VAPB) + + + + + + + + + pubmed:30740335 + + p(HGNC:XBP1) increases bp(GO:"positive regulation of protein folding") + + + + + + + pubmed:30740335 + + p(HGNC:XBP1) increases deg(p(MESH:"Mutant Proteins")) + + + + + + + pubmed:30740335 + + p(HGNC:XBP1) increases path(MESH:"Cell Survival") + + + + + + + + + pubmed:30740335 + + p(HGNC:XBP1) decreases p(HGNC:FOXO1) + + + + + + + pubmed:30740335 + + p(HGNC:XBP1) decreases p(HGNC:FOXO1) + + + + + + + pubmed:30740335 + + p(HGNC:XBP1) decreases path(MESH:Autophagy) + + + + + + + pubmed:30740335 + + p(HGNC:XBP1) increases deg(p(HGNC:SOD1, pmod(HBP:misfolded))) + + + + + + + pubmed:30740335 + + p(HGNC:XBP1) association bp(GO:"learning or memory") + + + + + + + pubmed:30740335 + + act(p(HGNC:XBP1)) association p(HGNC:BDNF) + + + + + + + pubmed:30740335 + + p(HGNC:XBP1) increases p(HGNC:HTT, pmod(HBP:misfolded)) + + + + + + + pubmed:30740335 + + p(HGNC:XBP1) increases a(MESH:"Protein Aggregates") + + + + + + + pubmed:30740335 + + p(HGNC:XBP1) increases bp(GO:"neuron death") + + + + + + + pubmed:25784053 + + act(p(HGNC:XBP1), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases bp(GO:"response to misfolded protein") + + + + + + + pubmed:21722302 + + p(HGNC:EIF2A, pmod(go:0006468 ! "protein phosphorylation", Ser, 51)) decreases bp(GO:translation) + + + + + + + pubmed:21722302 + + p(HGNC:EIF2A, pmod(go:0006468 ! "protein phosphorylation", Ser, 51)) increases bp(GO:"cap-independent translational initiation") + + + + + + + pubmed:21722302 + + p(HGNC:EIF2A, pmod(go:0006468 ! "protein phosphorylation", Ser, 51)) increases p(HGNC:ATF4) + + + + + + + pubmed:21722302 + + bp(GO:"cap-independent translational initiation") increases p(HGNC:ATF4) + + + + + + + pubmed:21722302 + + p(HGNC:ATF4) increases a(MESH:"Molecular Chaperones") + + + + + + + pubmed:21722302 + + p(HGNC:ATF4) increases p(HGNC:MAP1LC3B) + + + + + + + pubmed:21722302 + + p(HGNC:ATF4) increases p(HGNC:ATG5) + + + + + + + pubmed:21722302 + + p(HGNC:ATF4) increases bp(GO:autophagy) + + + + + + + pubmed:21722302 + + p(HGNC:ATF4) increases p(HGNC:PRKN) + + + + + + + pubmed:30740335 + + p(HGNC:ATF4) increases act(p(HGNC:DDIT3)) + + + + + + + pubmed:25784053 + + p(HGNC:ATF4) increases p(HGNC:DDIT3) + + + + + + + pubmed:27299292 + + p(HGNC:ATF4) association p(HGNC:TFEB) + + + + + + + pubmed:27299292 + + p(HGNC:ATF4) association p(HGNC:TFE3) + + + + + + + pubmed:21722302 + + a(MESH:"Molecular Chaperones") association bp(GO:"ERAD pathway") + + + + + + + pubmed:27491084 + + a(MESH:"Molecular Chaperones") decreases path(CONSO:proteotoxicity) + + + + + + + + + + + pubmed:23746257 + + a(MESH:"Molecular Chaperones") decreases a(MESH:"Protein Aggregates") + + + + + + + pubmed:25784053 + + a(MESH:"Molecular Chaperones") increases bp(CONSO:Proteostasis) + + + + + + + pubmed:25784053 + + a(MESH:"Molecular Chaperones") decreases path(MESH:"Protein Aggregation, Pathological") + + + + + + + + + pubmed:21882945 + + a(MESH:"Molecular Chaperones") association bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") + + + + + + + pubmed:29311797 + + a(MESH:"Molecular Chaperones") association bp(GO:"protein folding") + + + + + + + pubmed:29311797 + + a(MESH:"Molecular Chaperones") association bp(MESH:Proteolysis) + + + + + + + pubmed:29311797 + + a(MESH:"Molecular Chaperones") association deg(p(MESH:Proteins, pmod(CONSO:misfolded))) + + + + + + + pubmed:27181519 + + a(MESH:"Molecular Chaperones") regulates bp(GO:"stress granule disassembly") + + + + + + + pubmed:21722302 + + bp(GO:"ERAD pathway") association a(MESH:"Molecular Chaperones") + + + + + + + pubmed:21722302 + + bp(GO:"ERAD pathway") increases deg(p(MESH:Proteins, pmod(CONSO:misfolded))) + + + + + + + pubmed:21722302 + + bp(GO:"ERAD pathway") increases deg(p(MESH:Proteins, pmod(CONSO:misfolded))) + + + + + + + pubmed:21722302 + + bp(GO:"ERAD pathway") association path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:21722302 + + bp(GO:"ERAD pathway") decreases bp(MESH:"Endoplasmic Reticulum Stress") + + + + + + + pubmed:21722302 + + bp(GO:"ERAD pathway") decreases p(HGNC:DERL1) + + + + + + + pubmed:21722302 + + bp(GO:"ERAD pathway") negativeCorrelation complex(p(HGNC:DERL1), p(HGNC:SOD1, var("?"))) + + + + + + + pubmed:30740335 + + bp(GO:"ERAD pathway") association p(HGNC:ATF6) + + + + + + + pubmed:14556719 + + bp(GO:"ERAD pathway") regulates deg(p(HGNC:CFTR)) + + + + + + + pubmed:14556719 + + bp(GO:"ERAD pathway") increases deg(p(HGNC:PRNP, pmod(CONSO:misfolding))) + + + + + + + pubmed:24457024 + + bp(GO:"ERAD pathway") association complex(p(HGNC:BAG6), p(MESH:Proteins, pmod(CONSO:misfolding))) + + + + + + + pubmed:21722302 + + p(HGNC:CREB3L1) increases bp(MESH:"Bone Development") + + + + + + + pubmed:21722302 + + p(HGNC:CREB3L2) regulates p(HGNC:SEC23A) + + + + + + + pubmed:21722302 + + p(HGNC:SEC23A) increases tloc(a(MESH:Proteins), fromLoc(GO:"endoplasmic reticulum"), toLoc(GO:"Golgi apparatus")) + + + + + + + + + + + + + + + + + pubmed:22908190 + + tloc(a(MESH:Proteins), fromLoc(GO:cytosol), toLoc(GO:"lysosomal lumen")) increases deg(a(MESH:Proteins)) + + + + + + + pubmed:18930136 + + tloc(a(MESH:Proteins), fromLoc(GO:intracellular), toLoc(GO:lysosome)) increases deg(a(MESH:Proteins)) + + + + + + + pubmed:22908190 + + a(MESH:Proteins) positiveCorrelation act(p(HGNC:RAB5A)) + + + + + + + pubmed:22908190 + + a(MESH:Proteins) positiveCorrelation bp(GO:endocytosis) + + + + + + + + + pubmed:24457024 + + tloc(a(MESH:Proteins), fromLoc(GO:cytosol), toLoc(CONSO:"20 S Proteasome")) increases act(p(HGNC:PSMD14)) + + + + + + + + + + + + + + + + + pubmed:27181519 + + a(MESH:Proteins, loc(GO:phagophore)) increases a(GO:autophagosome) + + + + + + + pubmed:21722302 + + p(HGNC:ATF3) increases a(MESH:"Molecular Chaperones") + + + + + + + pubmed:21722302 + + bp(GO:"apoptotic signaling pathway") decreases complex(GO:"mitochondrial permeability transition pore complex") + + + + + + + pubmed:21722302 + + composite(p(HGNC:APAF1), p(HGNC:CASP9), p(HGNC:CYC1)) increases a(MESH:Apoptosomes) + + + + + + + + + + + + + pubmed:21722302 + + p(HGNC:CASP9) increases p(HGNC:CASP3) + + + + + + + pubmed:21722302 + + p(HGNC:CASP9) increases p(HGNC:CASP7) + + + + + + + pubmed:21722302 + + p(HGNC:CASP9) increases p(HGNC:CASP6) + + + + + + + + + + + + + pubmed:21722302 + + composite(p(HGNC:CASP3), p(HGNC:CASP6), p(HGNC:CASP7)) increases bp(MESH:Apoptosis) + + + + + + + pubmed:21722302 + + p(HGNC:CASP2) increases bp(MESH:Apoptosis) + + + + + + + pubmed:21722302 + + complex(GO:"PUMA-BCL-2 complex") increases bp(MESH:Apoptosis) + + + + + + + pubmed:21722302 + + p(HGNC:DDIT3) increases bp(MESH:"DNA Damage") + + + + + + + pubmed:21722302 + + p(HGNC:DDIT3) association complex(GO:"CHOP-C/EBP complex") + + + + + + + pubmed:21722302 + + p(HGNC:DDIT3) increases bp(MESH:"Cell Death") + + + + + + + pubmed:21722302 + + p(HGNC:DDIT3) decreases p(HGNC:BCL2) + + + + + + + pubmed:30740335 + + p(HGNC:DDIT3) decreases act(p(HGNC:BCL2)) + + + + + + + pubmed:21722302 + + p(HGNC:DDIT3) increases a(MESH:"Reactive Oxygen Species") + + + + + + + pubmed:21722302 + + p(HGNC:DDIT3) increases p(MGI:Casp4) + + + + + + + pubmed:21722302 + + p(HGNC:DDIT3) increases complex(GO:"BIM-BCL-2 complex") + + + + + + + pubmed:21722302 + + p(HGNC:DDIT3) decreases r(HGNC:BCL2) + + + + + + + pubmed:21722302 + + p(HGNC:DDIT3) increases p(HGNC:MAP1LC3B) + + + + + + + pubmed:21722302 + + p(HGNC:DDIT3) increases p(HGNC:ATG5) + + + + + + + pubmed:21722302 + + p(HGNC:DDIT3) increases bp(GO:autophagy) + + + + + + + pubmed:21722302 + + p(HGNC:DDIT3) decreases g(HGNC:PRKN) + + + + + + + pubmed:21722302 + + p(HGNC:DDIT3) biomarkerFor bp(MESH:"Endoplasmic Reticulum Stress") + + + + + + + pubmed:30740335 + + p(HGNC:DDIT3) increases path(MESH:Apoptosis) + + + + + + + pubmed:25784053 + + p(HGNC:DDIT3) increases bp(GO:"apoptotic process") + + + + + + + pubmed:23702978 + + p(HGNC:DDIT3) regulates a(CHEBI:"calcium(2+)") + + + + + + + pubmed:23702978 + + p(HGNC:DDIT3) increases act(complex(GO:"NLRP3 inflammasome complex")) + + + + + + + pubmed:30126037 + + bp(MESH:"DNA Damage") association bp(GO:"cellular senescence") + + + + + + + pubmed:21722302 + + complex(GO:"CHOP-C/EBP complex") association p(HGNC:DDIT3) + + + + + + + pubmed:21722302 + + complex(GO:"CHOP-C/EBP complex") increases bp(MESH:"Cell Death") + + + + + + + pubmed:21722302 + + p(MGI:Casp4) increases p(HGNC:CASP1) + + + + + + + pubmed:21722302 + + p(MGI:Casp4) increases p(HGNC:CASP3) + + + + + + + pubmed:21722302 + + p(MESH:Oxidoreductases) increases tloc(p(MESH:Proteins, pmod(CONSO:misfolded)), fromLoc(GO:"endoplasmic reticulum"), toLoc(GO:cytoplasm)) + + + + + + + pubmed:21722302 + + p(HGNCGENEFAMILY:Proteasome) decreases deg(p(MESH:Proteins, pmod(CONSO:misfolded))) + + + + + + + pubmed:21722302 + + p(HGNCGENEFAMILY:Proteasome) increases deg(p(MESH:Proteins, pmod(CONSO:misfolded))) + + + + + + + + + pubmed:24027553 + + act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination"))) + + + + + + + pubmed:24027553 + + p(HGNCGENEFAMILY:Proteasome) increases deg(p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination"))) + + + + + + + pubmed:24027553 + + act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(HGNC:MAPT)) + + + + + + + pubmed:24027553 + + p(HGNCGENEFAMILY:Proteasome) increases deg(p(HGNC:MAPT)) + + + + + + + pubmed:24027553 + + act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(HGNC:MAPT)) + + + + + + + pubmed:24027553 + + act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(RGD:Mapt)) + + + + + + + pubmed:24027553 + + act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 396), pmod(go:0006468 ! "protein phosphorylation", Ser, 404))) + + + + + + + pubmed:24027553 + + act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) + + + + + + + pubmed:24027553 + + act(p(HGNCGENEFAMILY:Proteasome)) causesNoChange deg(a(CONSO:"Tau aggregates")) + + + + + + + pubmed:24027553 + + act(p(HGNCGENEFAMILY:Proteasome)) causesNoChange deg(a(CONSO:"Tau oligomers")) + + + + + + + pubmed:21722302 + + complex(GO:"Atg1/ULK1 kinase complex") increases bp(GO:autophagy) + + + + + + + pubmed:21722302 + + complex(GO:"Atg1/ULK1 kinase complex") increases a(GO:phagophore) + + + + + + + + + pubmed:30606258 + + p(HGNCGENEFAMILY:"MTOR complex 1") increases p(HGNC:RPS6KB1, pmod(go:0006468 ! "protein phosphorylation", Thr, 398)) + + + + + + + pubmed:30606258 + + p(HGNCGENEFAMILY:"MTOR complex 1") negativeCorrelation act(p(HGNC:INS)) + + + + + + + pubmed:30606258 + + p(HGNCGENEFAMILY:"MTOR complex 1") increases p(HGNC:IRS1, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + + + + + pubmed:30606258 + + p(HGNCGENEFAMILY:"MTOR complex 1") increases p(HGNC:IRS1, pmod(go:0006468 ! "protein phosphorylation", Ser, 636)) + + + + + + + pubmed:30606258 + + p(HGNCGENEFAMILY:"MTOR complex 1") increases p(HGNC:IRS1, pmod(go:0006468 ! "protein phosphorylation", Ser, 639)) + + + + + + + pubmed:30606258 + + p(HGNCGENEFAMILY:"MTOR complex 1") increases p(HGNC:IRS1, pmod(go:0006468 ! "protein phosphorylation", Ser, 1101)) + + + + + + + + + pubmed:27209302 + + act(p(HGNCGENEFAMILY:"MTOR complex 1")) increases tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) + + + + + + + pubmed:30108137 + + p(HGNCGENEFAMILY:"MTOR complex 1") increases p(HGNC:TFEB, loc(GO:cytoplasm)) + + + + + + + pubmed:27299292 + + act(p(HGNCGENEFAMILY:"MTOR complex 1"), ma(go:0016301 ! "kinase activity")) increases p(HGNC:TFEB, loc(GO:cytosol)) + + + + + + + pubmed:27299292 + + p(HGNCGENEFAMILY:"MTOR complex 1") decreases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) + + + + + + + pubmed:27299292 + + p(HGNCGENEFAMILY:"MTOR complex 1") decreases act(p(HGNC:TFEB)) + + + + + + + pubmed:26702100 + + p(HGNCGENEFAMILY:"MTOR complex 1") regulates p(HGNC:TFEB) + + + + + + + pubmed:26702100 + + p(HGNCGENEFAMILY:"MTOR complex 1") increases p(HGNC:TFEB, loc(GO:nucleus)) + + + + + + + pubmed:26968346 + + act(p(HGNCGENEFAMILY:"MTOR complex 1"), ma(go:0016301 ! "kinase activity")) increases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation", Ser, 142)) + + + + + + + pubmed:27299292 + + p(HGNCGENEFAMILY:"MTOR complex 1") increases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation", Ser, 142)) + + + + + + + pubmed:26968346 + + act(p(HGNCGENEFAMILY:"MTOR complex 1"), ma(go:0016301 ! "kinase activity")) increases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation", Ser, 211)) + + + + + + + pubmed:27299292 + + p(HGNCGENEFAMILY:"MTOR complex 1") increases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation", Ser, 211)) + + + + + + + pubmed:26702100 + + p(HGNCGENEFAMILY:"MTOR complex 1") increases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation", Ser, 211)) + + + + + + + pubmed:26968346 + + tloc(p(HGNCGENEFAMILY:"MTOR complex 1"), fromLoc(GO:cytoplasm), toLoc(GO:"lysosomal membrane")) increases act(p(HGNCGENEFAMILY:"MTOR complex 1")) + + + + + + + pubmed:27299292 + + p(HGNCGENEFAMILY:"MTOR complex 1", loc(GO:"plasma membrane")) causesNoChange act(p(HGNCGENEFAMILY:"MTOR complex 1")) + + + + + + + + + pubmed:30108137 + + p(HGNCGENEFAMILY:"MTOR complex 1") increases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:27299292 + + act(p(HGNCGENEFAMILY:"MTOR complex 1"), ma(go:0016301 ! "kinase activity")) increases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:26702100 + + p(HGNCGENEFAMILY:"MTOR complex 1") increases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:27299292 + + act(p(HGNCGENEFAMILY:"MTOR complex 1"), ma(go:0016301 ! "kinase activity")) association bp(GO:"biosynthetic process") + + + + + + + pubmed:27299292 + + act(p(HGNCGENEFAMILY:"MTOR complex 1"), ma(go:0016301 ! "kinase activity")) association bp(GO:"catabolic process") + + + + + + + pubmed:27299292 + + p(HGNCGENEFAMILY:"MTOR complex 1") positiveCorrelation p(HGNC:TSC2) + + + + + + + pubmed:27299292 + + act(p(HGNCGENEFAMILY:"MTOR complex 1")) regulates act(a(MESH:Lysosomes)) + + + + + + + pubmed:27299292 + + act(p(HGNCGENEFAMILY:"MTOR complex 1")) association complex(GO:"Ragulator complex") + + + + + + + pubmed:27299292 + + act(p(HGNCGENEFAMILY:"MTOR complex 1")) increases p(HGNC:MITF, loc(GO:cytoplasm)) + + + + + + + pubmed:27299292 + + act(p(HGNCGENEFAMILY:"MTOR complex 1")) increases p(HGNC:TFE3, loc(GO:cytoplasm)) + + + + + + + pubmed:27299292 + + act(p(HGNCGENEFAMILY:"MTOR complex 1")) positiveCorrelation p(HGNC:FLCN) + + + + + + + pubmed:27299292 + + tloc(p(HGNCGENEFAMILY:"MTOR complex 1"), fromLoc(GO:cytoplasm), toLoc(GO:"lysosomal membrane")) association p(HGNC:FLCN) + + + + + + + pubmed:27299292 + + act(p(HGNCGENEFAMILY:"MTOR complex 1")) association p(HGNC:FLCN) + + + + + + + pubmed:27299292 + + act(p(HGNCGENEFAMILY:"MTOR complex 1")) decreases p(HGNC:AR, pmod(CONSO:"CAG repeats")) + + + + + + + pubmed:27299292 + + act(p(HGNCGENEFAMILY:"MTOR complex 1")) negativeCorrelation path(DOID:"spinal muscular atrophy") + + + + + + + pubmed:27299292 + + p(HGNCGENEFAMILY:"MTOR complex 1") association p(HGNC:SESN2) + + + + + + + + + pubmed:27299292 + + p(HGNCGENEFAMILY:"MTOR complex 1") negativeCorrelation complex(p(HGNC:IPO8), p(HGNC:TFE3)) + + + + + + + pubmed:27299292 + + p(HGNCGENEFAMILY:"MTOR complex 1") negativeCorrelation complex(p(HGNC:IPO8), p(HGNC:TFEB)) + + + + + + + pubmed:27299292 + + p(HGNCGENEFAMILY:"MTOR complex 1") negativeCorrelation complex(p(HGNC:IPO8), p(HGNC:MITF)) + + + + + + + pubmed:26702100 + + act(p(HGNCGENEFAMILY:"MTOR complex 1")) negativeCorrelation p(HGNC:RPS6KB1, pmod(go:0006468 ! "protein phosphorylation", Thr, 389)) + + + + + + + pubmed:26702100 + + act(p(HGNCGENEFAMILY:"MTOR complex 1")) association p(HGNC:RPS6KB1) + + + + + + + + + + + pubmed:26702100 + + p(HGNCGENEFAMILY:"MTOR complex 1") association act(p(HGNC:TARDBP)) + + + + + + + + + pubmed:21722302 + + p(HGNCGENEFAMILY:"TSC complex") regulates p(HGNC:MTOR) + + + + + + + pubmed:21722302 + + path(MESH:Starvation) increases act(p(HGNC:PRKAA1)) + + + + + + + pubmed:26968346 + + path(MESH:Starvation) decreases p(HGNCGENEFAMILY:"MTOR complex 1") + + + + + + + pubmed:26968346 + + path(MESH:Starvation) increases tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) + + + + + + + pubmed:29758300 + + path(MESH:Starvation) increases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) + + + + + + + pubmed:26968346 + + path(MESH:Starvation) increases composite(a(CHEBI:"calcium(2+)"), p(HGNC:MCOLN1)) + + + + + + + pubmed:30562574 + + path(MESH:Starvation) increases bp(GO:"chaperone-mediated autophagy") + + + + + + + pubmed:29758300 + + path(MESH:Starvation) increases rxn(reactants(a(CHEBI:lipid)), products(a(CHEBI:"fatty acid"), a(CHEBI:ATP))) + + + + + + + pubmed:29758300 + + path(MESH:Starvation) increases complex(p(HGNC:TFEB), p(INTERPRO:"cAMP response element binding (CREB) protein")) + + + + + + + pubmed:18930136 + + path(MESH:Starvation) increases tloc(p(HGNC:WDFY3), fromLoc(GO:nucleus), toLoc(GO:cytoplasm)) + + + + + + + pubmed:29238289 + + path(MESH:Starvation) increases tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:26702100 + + path(MESH:Starvation) decreases p(HGNC:MTOR) + + + + + + + pubmed:26702100 + + path(MESH:Starvation) decreases p(HGNC:RPS6KB1, pmod(go:0006468 ! "protein phosphorylation", Thr, 389)) + + + + + + + pubmed:26702100 + + path(MESH:Starvation) increases a(GO:autophagosome) + + + + + + + pubmed:26702100 + + path(MESH:Starvation) decreases a(GO:autolysosome) + + + + + + + pubmed:21722302 + + bp(MESH:"Heat-Shock Response") increases act(p(HGNC:PRKAA1)) + + + + + + + pubmed:14556719 + + bp(MESH:"Heat-Shock Response") increases bp(GO:"response to unfolded protein") + + + + + + + pubmed:23746257 + + bp(MESH:"Heat-Shock Response") increases a(MESH:"Heat-Shock Proteins") + + + + + + + pubmed:23746257 + + bp(MESH:"Heat-Shock Response") association p(FPLX:HSP90) + + + + + + + pubmed:23746257 + + bp(MESH:"Heat-Shock Response") regulates bp(CONSO:Proteostasis) + + + + + + + pubmed:29807032 + + bp(MESH:"Heat-Shock Response") association act(p(NCBIGENE:140621)) + + + + + + + pubmed:29807032 + + bp(MESH:"Heat-Shock Response") increases act(p(NCBIGENE:140621)) + + + + + + + pubmed:29807032 + + bp(MESH:"Heat-Shock Response") increases p(NCBIGENE:492507) + + + + + + + pubmed:29807032 + + bp(MESH:"Heat-Shock Response") increases r(MESH:"corticotropin releasing factor-binding protein") + + + + + + + pubmed:29807032 + + bp(MESH:"Heat-Shock Response") decreases a(MESH:"Embryonic Structures") + + + + + + + pubmed:29807032 + + bp(MESH:"Heat-Shock Response") decreases a(MESH:"Embryonic Structures") + + + + + + + pubmed:29807032 + + bp(MESH:"Heat-Shock Response") decreases a(MESH:"Embryonic Structures") + + + + + + + pubmed:21722302 + + a(CHEBI:tunicamycin) increases bp(GO:autophagy) + + + + + + + pubmed:30740335 + + a(CHEBI:tunicamycin) increases path(MESH:"Endoplasmic Reticulum Stress") + + + + + + + pubmed:21722302 + + a(MESH:"Proteasome Inhibitors") increases bp(GO:autophagy) + + + + + + + + + pubmed:21722302 + + p(HGNC:SOD1, pmod(MESH:"Mutant Proteins")) increases bp(CONSO:"protein aggregation") + + + + + + + pubmed:21722302 + + p(HGNC:HTT, pmod(MESH:polyglutamine)) increases p(HGNC:EIF2AK3) + + + + + + + + + + + + + + + + + pubmed:21722302 + + composite(p(HGNC:ATG12), p(HGNC:HTT, pmod(MESH:polyglutamine))) increases bp(GO:autophagy) + + + + + + + pubmed:27299292 + + p(HGNC:ATG5) association composite(p(HGNC:MITF), p(HGNC:TFE3), p(HGNC:TFEB)) + + + + + + + + + + + + + + + pubmed:18930136 + + p(HGNC:ATG5) decreases path(CONSO:Neurodegeneration) + + + + + + + pubmed:26702100 + + p(HGNC:ATG5) association bp(GO:autophagy) + + + + + + + pubmed:21722302 + + p(HGNC:NUPR1) increases bp(GO:autophagy) + + + + + + + pubmed:21722302 + + p(HGNC:TRIB3) increases bp(GO:autophagy) + + + + + + + pubmed:21722302 + + path(MESH:"Amyloidosis, Cerebral, with Spongiform Encephalopathy") association bp(CONSO:"protein aggregation") + + + + + + + pubmed:21722302 + + path(MESH:"Brain Ischemia") association bp(CONSO:"protein aggregation") + + + + + + + pubmed:21722302 + + path(HP:"Senile plaques") association path(MESH:"Alzheimer Disease") + + + + + + + pubmed:21722302 + + path(HP:"Senile plaques") increases a(CONSO:"amyloid-beta aggregates") + + + + + + + pubmed:21722302 + + path(HP:"Senile plaques") increases a(MESH:"Neurofibrillary Tangles") + + + + + + + pubmed:21722302 + + path(HP:"Senile plaques") increases a(MESH:"Neurofibrillary Tangles") + + + + + + + pubmed:21722302 + + path(HP:"Senile plaques") association path(MESH:"Neurodegenerative Diseases") + + + + + + + pubmed:21722302 + + path(MESH:Neurites) association path(MESH:"Alzheimer Disease") + + + + + + + + + + + pubmed:21722302 + + p(PFAM:Presenilin) isA complex(GO:"ER membrane protein complex") + + + + + + + pubmed:21722302 + + p(PFAM:Presenilin) association p(HGNC:ERN1) + + + + + + + pubmed:21722302 + + p(PFAM:Presenilin) association p(HGNC:EIF2AK3) + + + + + + + pubmed:21722302 + + p(PFAM:Presenilin) decreases p(HGNC:EIF2AK3, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:21722302 + + p(PFAM:Presenilin) decreases p(HGNC:EIF2A, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:21722302 + + p(PFAM:Presenilin, var("?")) association path(MESH:"Alzheimer Disease") + + + + + + + pubmed:21722302 + + p(PFAM:Presenilin, var("?")) decreases path(MESH:"Age of Onset") + + + + + + + pubmed:21722302 + + p(HGNC:UBQLN1) negativeCorrelation complex(FPLX:"Gamma_secretase") + + + + + + + pubmed:21722302 + + p(HGNC:UBQLN1) regulates p(HGNC:APP) + + + + + + + pubmed:21722302 + + p(HGNC:UBQLN1) regulates a(CHEBI:amyloid-beta) + + + + + + + pubmed:22908190 + + p(HGNC:UBQLN1) association path(MESH:"Alzheimer Disease") + + + + + + + + + pubmed:22908190 + + p(HGNC:UBQLN1) increases complex(a(GO:"proteasome complex"), p(HGNC:UBQLN1)) + + + + + + + + + pubmed:22908190 + + p(HGNC:UBQLN1) increases complex(p(HGNC:UBQLN1), p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination"))) + + + + + + + pubmed:22908190 + + p(HGNC:UBQLN1) regulates deg(p(HGNC:PSEN1)) + + + + + + + + + pubmed:21722302 + + path(HP:"Postural instability") prognosticBiomarkerFor path(MESH:"Parkinson Disease") + + + + + + + pubmed:21722302 + + path(HP:"Resting tremor") prognosticBiomarkerFor path(MESH:"Parkinson Disease") + + + + + + + pubmed:21722302 + + path(DOID:"olfactory nerve disease") prognosticBiomarkerFor path(MESH:"Parkinson Disease") + + + + + + + pubmed:21722302 + + path(CONSO:"Gastrointestinal dysfunctions") prognosticBiomarkerFor path(MESH:"Parkinson Disease") + + + + + + + pubmed:21722302 + + a(GO:"Lewy neurite") biomarkerFor path(MESH:"Parkinson Disease") + + + + + + + pubmed:21722302 + + path(DOID:"autosomal dominant Parkinson's disease 1") association g(HGNC:SNCA) + + + + + + + pubmed:21722302 + + path(DOID:"autosomal dominant Parkinson's disease 1") association g(HGNC:UCHL1) + + + + + + + pubmed:21722302 + + path(DOID:"autosomal dominant Parkinson's disease 1") association g(HGNC:LRRK2) + + + + + + + pubmed:21722302 + + path(DOID:"autosomal dominant Parkinson's disease 1") association p(HGNC:UCHL1, var("?")) + + + + + + + pubmed:21722302 + + g(HGNC:SNCA) association path(DOID:"autosomal dominant Parkinson's disease 1") + + + + + + + + + pubmed:21722302 + + g(HGNC:UCHL1) association path(DOID:"autosomal dominant Parkinson's disease 1") + + + + + + + pubmed:21722302 + + g(HGNC:LRRK2) association path(DOID:"autosomal dominant Parkinson's disease 1") + + + + + + + pubmed:21722302 + + path(DOID:"autosomal recessive Parkinson's disease 14") association g(HGNC:PRKN) + + + + + + + pubmed:21722302 + + path(DOID:"autosomal recessive Parkinson's disease 14") association g(HGNC:PINK1) + + + + + + + pubmed:21722302 + + path(DOID:"autosomal recessive Parkinson's disease 14") association g(HGNC:PARK7) + + + + + + + pubmed:21722302 + + path(DOID:"autosomal recessive Parkinson's disease 14") association g(HGNC:ATP13A2) + + + + + + + pubmed:21722302 + + path(DOID:"autosomal recessive Parkinson's disease 14") association g(HGNC:PRKN, var("?")) + + + + + + + pubmed:21722302 + + g(HGNC:PRKN) association path(DOID:"autosomal recessive Parkinson's disease 14") + + + + + + + + + pubmed:21722302 + + g(HGNC:PINK1) association path(DOID:"autosomal recessive Parkinson's disease 14") + + + + + + + + + pubmed:21722302 + + g(HGNC:PARK7) association path(DOID:"autosomal recessive Parkinson's disease 14") + + + + + + + + + pubmed:21722302 + + g(HGNC:ATP13A2) association path(DOID:"autosomal recessive Parkinson's disease 14") + + + + + + + pubmed:21722302 + + p(HGNC:SNCA, pmod(go:0017014 ! "protein nitrosylation")) increases p(HGNC:SNCA, pmod(CONSO:misfolded)) + + + + + + + pubmed:21722302 + + p(HGNC:SNCA, var("p.Ala53Thr")) increases bp(MESH:"Unfolded Protein Response") + + + + + + + + + + + pubmed:14556719 + + p(HGNC:SNCA, var("p.Ala53Thr")) association path(MESH:"Parkinson Disease") + + + + + + + pubmed:28803412 + + p(HGNC:SNCA, var("p.Ala53Thr")) increases path(MESH:"Parkinson Disease") + + + + + + + pubmed:14556719 + + p(HGNC:SNCA, var("p.Ala53Thr")) increases a(CONSO:"alpha-synuclein fibrils") + + + + + + + pubmed:21722302 + + composite(p(HGNC:EIF2A, pmod(go:0006468 ! "protein phosphorylation")), p(HGNC:SNCA, var("p.Ala53Thr"))) increases bp(MESH:"Cell Death") + + + + + + + pubmed:27299292 + + bp(GO:"protein catabolic process") increases deg(p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) + + + + + + + pubmed:27299292 + + bp(GO:"protein catabolic process") increases deg(p(HGNC:MAPT, pmod(CONSO:misfolded))) + + + + + + + pubmed:14556719 + + bp(GO:"protein catabolic process") increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + + + + + + + pubmed:23746257 + + bp(GO:"protein catabolic process") association act(p(FPLX:HSPA)) + + + + + + + pubmed:21722302 + + p(HGNC:UCHL1, var("?")) association path(DOID:"autosomal dominant Parkinson's disease 1") + + + + + + + pubmed:21722302 + + p(HGNC:UCHL1, var("?")) decreases bp(GO:"chaperone-mediated autophagy") + + + + + + + pubmed:14556719 + + p(HGNC:UCHL1, var("?")) association path(MESH:"Parkinson Disease") + + + + + + + pubmed:14556719 + + p(HGNC:UCHL1, var("?")) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + + + + + + + pubmed:23528736 + + p(HGNC:UCHL1, var("?")) association path(MESH:"Neurodegenerative Diseases") + + + + + + + pubmed:23528736 + + p(HGNC:UCHL1, var("?")) association path(MESH:"Alzheimer Disease") + + + + + + + pubmed:21722302 + + bp(GO:"chaperone-mediated autophagy") association p(HGNC:UCHL1) + + + + + + + pubmed:21722302 + + bp(GO:"chaperone-mediated autophagy") increases deg(a(CONSO:"alpha-synuclein aggregates")) + + + + + + + pubmed:26968346 + + bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:HTT)) + + + + + + + pubmed:30116051 + + bp(GO:"chaperone-mediated autophagy") causesNoChange deg(p(HGNC:HTT)) + + + + + + + pubmed:26968346 + + bp(GO:"chaperone-mediated autophagy") negativeCorrelation p(HGNC:SNCA, var("?")) + + + + + + + pubmed:29758300 + + bp(GO:"chaperone-mediated autophagy") association p(HGNC:SNCA, var("?")) + + + + + + + pubmed:26968346 + + bp(GO:"chaperone-mediated autophagy") decreases p(CONSO:"alpha-synuclein aggregates") + + + + + + + pubmed:27299292 + + bp(GO:"chaperone-mediated autophagy") positiveCorrelation deg(p(HGNC:TFEB)) + + + + + + + pubmed:27299292 + + bp(GO:"chaperone-mediated autophagy") decreases bp(GO:macroautophagy) + + + + + + + pubmed:30562574 + + bp(GO:"chaperone-mediated autophagy") negativeCorrelation bp(GO:macroautophagy) + + + + + + + pubmed:30562574 + + bp(GO:"chaperone-mediated autophagy") increases deg(a(MESH:Proteins, loc(GO:lysosome))) + + + + + + + pubmed:22908190 + + bp(GO:"chaperone-mediated autophagy") increases tloc(a(MESH:Proteins), fromLoc(GO:cytosol), toLoc(GO:"lysosomal lumen")) + + + + + + + pubmed:18930136 + + bp(GO:"chaperone-mediated autophagy") increases tloc(a(MESH:Proteins), fromLoc(GO:cytoplasm), toLoc(GO:"lysosomal lumen")) + + + + + + + pubmed:30562574 + + bp(GO:"chaperone-mediated autophagy") association path(MESH:"Neurodegenerative Diseases") + + + + + + + pubmed:29311797 + + bp(GO:"chaperone-mediated autophagy") negativeCorrelation path(MESH:"Neurodegenerative Diseases") + + + + + + + pubmed:30562574 + + bp(GO:"chaperone-mediated autophagy") association path(DOID:"Parkinson's disease") + + + + + + + pubmed:30562574 + + bp(GO:"chaperone-mediated autophagy") association bp(GO:aging) + + + + + + + pubmed:30562574 + + bp(GO:"chaperone-mediated autophagy") isA bp(GO:"cellular protein catabolic process") + + + + + + + pubmed:29758300 + + bp(GO:"chaperone-mediated autophagy") decreases a(CONSO:"protein aggregates") + + + + + + + pubmed:29758300 + + bp(GO:"chaperone-mediated autophagy") causesNoChange deg(a(CONSO:"protein aggregates")) + + + + + + + pubmed:29758300 + + bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:MAPT)) + + + + + + + pubmed:22908190 + + bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:MAPT)) + + + + + + + pubmed:30116051 + + bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:MAPT)) + + + + + + + pubmed:30116051 + + bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:MAPT)) + + + + + + + pubmed:29758300 + + bp(GO:"chaperone-mediated autophagy") association p(HGNC:SNCA) + + + + + + + pubmed:29758300 + + bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:SNCA)) + + + + + + + pubmed:18930136 + + bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:SNCA)) + + + + + + + pubmed:18930136 + + bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:SNCA)) + + + + + + + pubmed:18930136 + + bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:SNCA)) + + + + + + + pubmed:30116051 + + bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:SNCA)) + + + + + + + pubmed:30116051 + + bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:SNCA)) + + + + + + + pubmed:18930136 + + bp(GO:"chaperone-mediated autophagy") association p(HGNC:HSPA8) + + + + + + + pubmed:24563850 + + bp(GO:"chaperone-mediated autophagy") decreases path(MESH:"Protein Aggregation, Pathological") + + + + + + + pubmed:30116051 + + bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:TARDBP)) + + + + + + + pubmed:30116051 + + bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:APP)) + + + + + + + pubmed:30116051 + + bp(GO:"chaperone-mediated autophagy") causesNoChange deg(a(CHEBI:"amyloid-beta polypeptide 42")) + + + + + + + pubmed:30116051 + + bp(GO:"chaperone-mediated autophagy") causesNoChange deg(p(HGNC:HTT, var("?"))) + + + + + + + pubmed:30116051 + + bp(GO:"chaperone-mediated autophagy") causesNoChange deg(p(HGNC:HTT, frag("?"))) + + + + + + + pubmed:30116051 + + bp(GO:"chaperone-mediated autophagy") increases act(p(HGNC:MEF2D)) + + + + + + + pubmed:29024336 + + bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt)) + + + + + + + pubmed:29024336 + + bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt)) + + + + + + + pubmed:29024336 + + bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt)) + + + + + + + pubmed:29024336 + + bp(GO:"chaperone-mediated autophagy") increases deg(p(CONSO:CONSO00053)) + + + + + + + pubmed:29024336 + + bp(GO:"chaperone-mediated autophagy") increases deg(p(CONSO:CONSO00053)) + + + + + + + pubmed:29024336 + + bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt, var("p.Ala152Thr"))) + + + + + + + pubmed:29024336 + + bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt, var("p.Ala152Thr"))) + + + + + + + pubmed:29024336 + + bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt, var("p.Ala152Thr"))) + + + + + + + pubmed:29024336 + + bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt, var("p.Pro301Leu"))) + + + + + + + pubmed:29024336 + + bp(GO:"chaperone-mediated autophagy") causesNoChange deg(p(MGI:Mapt, var("p.Pro301Leu"))) + + + + + + + pubmed:29024336 + + bp(GO:"chaperone-mediated autophagy") decreases path(MESH:"Proteostasis Deficiencies") + + + + + + + pubmed:25374103 + + bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:MAPT, pmod(CONSO:misfolded))) + + + + + + + pubmed:29311797 + + bp(GO:"chaperone-mediated autophagy") association p(FPLX:HSP90) + + + + + + + pubmed:29311797 + + bp(GO:"chaperone-mediated autophagy") association p(HGNC:STIP1) + + + + + + + pubmed:21722302 + + g(HGNC:PRKN, var("?")) association path(DOID:"autosomal recessive Parkinson's disease 14") + + + + + + + pubmed:21722302 + + g(HGNC:PRKN, var("?")) decreases bp(MESH:"Protein Stability") + + + + + + + pubmed:21722302 + + bp(GO:"negative regulation of ubiquitin protein ligase activity") increases p(MESH:Proteins, pmod(CONSO:misfolded)) + + + + + + + pubmed:21722302 + + p(HGNCGENEFAMILY:"Voltage dependent anion channels", pmod(go:0016567 ! "protein ubiquitination")) increases bp(MESH:"Mitochondrial Degradation") + + + + + + + + + pubmed:21722302 + + bp(GO:"parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization") association path(MESH:"Parkinson Disease") + + + + + + + pubmed:21722302 + + bp(MESH:"Protein Stability") association p(HGNC:PINK1, var("?")) + + + + + + + pubmed:21722302 + + p(HGNC:PARK7, var("?")) association path(MESH:"Parkinson Disease") + + + + + + + pubmed:21722302 + + p(HGNC:PARK7, var("?")) increases bp(MESH:"Oxidative Stress") + + + + + + + pubmed:21722302 + + p(HGNC:PARK7, var("?")) increases bp(MESH:"Endoplasmic Reticulum Stress") + + + + + + + pubmed:24563850 + + bp(GO:"detection of redox state") association a(CHEBI:radical) + + + + + + + pubmed:21722302 + + a(MESH:Paraquat) isA a(CHEBI:herbicide) + + + + + + + pubmed:21722302 + + a(MESH:Paraquat) association path(MESH:"Parkinson Disease") + + + + + + + pubmed:21722302 + + a(MESH:Paraquat) increases p(HGNC:HSPA5) + + + + + + + pubmed:21722302 + + a(MESH:Paraquat) increases p(HGNC:DDIT3) + + + + + + + pubmed:21722302 + + a(MESH:Paraquat) increases act(p(HGNC:ERN1)) + + + + + + + pubmed:21722302 + + a(MESH:Paraquat) increases act(p(HGNC:MAP3K5)) + + + + + + + pubmed:21722302 + + a(MESH:Paraquat) increases bp(GO:"JNK cascade") + + + + + + + pubmed:21722302 + + a(MESH:Paraquat) increases bp(MESH:Apoptosis) + + + + + + + pubmed:21722302 + + g(HGNC:PINK1, var("?")) decreases bp(MESH:"Protein Stability") + + + + + + + pubmed:21722302 + + g(HGNC:PARK7, var("?")) decreases bp(MESH:"Protein Stability") + + + + + + + pubmed:14556719 + + g(HGNC:PARK7, var("?")) association path(MESH:"Parkinsonian Disorders") + + + + + + + pubmed:21722302 + + g(HGNC:SNCA, var("?")) decreases bp(MESH:"Protein Stability") + + + + + + + pubmed:21722302 + + a(MESH:1-Methyl-4-phenylpyridinium) increases path(MESH:"Parkinson Disease") + + + + + + + pubmed:21722302 + + a(MESH:1-Methyl-4-phenylpyridinium) directlyIncreases bp(MESH:"Endoplasmic Reticulum Stress") + + + + + + + pubmed:30562574 + + act(a(MESH:1-Methyl-4-phenylpyridinium)) increases bp(GO:"cell death") + + + + + + + pubmed:21722302 + + a(MESH:Hydroxydopamines) directlyIncreases bp(MESH:"Endoplasmic Reticulum Stress") + + + + + + + pubmed:25036637 + + bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") association p(HGNC:LTN1) + + + + + + + pubmed:21882945 + + bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") association a(MESH:"Molecular Chaperones") + + + + + + + pubmed:21882945 + + bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") association p(HGNC:MAPT, var("?")) + + + + + + + pubmed:27181519 + + bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") association a(CHEBI:"all-trans-retinoic acid") + + + + + + + pubmed:21722302 + + a(CONSO:"Motor Neurons") association path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:21722302 + + bp(GO:"motor neuron apoptotic process") association bp(GO:"axonal transport") + + + + + + + pubmed:27181519 + + bp(GO:"motor neuron apoptotic process") positiveCorrelation path(DOID:"amyotrophic lateral sclerosis") + + + + + + + pubmed:27181519 + + bp(GO:"motor neuron apoptotic process") positiveCorrelation bp(GO:"muscle atrophy") + + + + + + + pubmed:21722302 + + a(GO:"Bunina body") association path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:14556719 + + a(GO:"Bunina body") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) + + + + + + + pubmed:14556719 + + a(GO:"Bunina body") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) + + + + + + + pubmed:21722302 + + a(CHEBI:ubiquitin) association path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:21722302 + + p(HGNCGENEFAMILY:"Protein disulfide isomerases") association path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:24563850 + + p(HGNCGENEFAMILY:"Protein disulfide isomerases") decreases bp(GO:"protein oxidation") + + + + + + + pubmed:24563850 + + p(HGNCGENEFAMILY:"Protein disulfide isomerases") decreases bp(CONSO:misfolding) + + + + + + + pubmed:24563850 + + p(HGNCGENEFAMILY:"Protein disulfide isomerases") decreases a(MESH:"Protein Aggregates") + + + + + + + pubmed:21722302 + + p(HGNC:DERL1) increases p(HGNC:MAP3K5) + + + + + + + + + pubmed:21722302 + + complex(p(HGNC:DERL1), p(HGNC:SOD1, var("?"))) negativeCorrelation bp(GO:"ERAD pathway") + + + + + + + pubmed:21722302 + + p(HGNC:VAPB, var("?")) association path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:21722302 + + p(HGNC:VAPB, var("?")) decreases bp(MESH:"Unfolded Protein Response") + + + + + + + pubmed:21722302 + + p(HGNC:VAPB, var("?")) increases bp(CONSO:"protein aggregation") + + + + + + + + + pubmed:21722302 + + p(HGNC:VAPB) association bp(MESH:"Unfolded Protein Response") + + + + + + + pubmed:21722302 + + p(HGNC:VAPB) association p(HGNC:XBP1) + + + + + + + pubmed:21722302 + + p(HGNC:VAPB) association p(HGNC:ERN1) + + + + + + + pubmed:21722302 + + p(HGNC:VAPB) association p(HGNC:ATF6) + + + + + + + + + + + + + pubmed:21722302 + + p(HGNC:VAPB, pmod(go:0016567 ! "protein ubiquitination"), var("p.Pro56Ser")) decreases p(HGNC:XBP1) + + + + + + + pubmed:21722302 + + p(HGNC:VAPB, pmod(go:0016567 ! "protein ubiquitination"), var("p.Pro56Ser")) decreases p(HGNC:ERN1) + + + + + + + pubmed:21722302 + + p(HGNC:VAPB, pmod(go:0016567 ! "protein ubiquitination"), var("p.Pro56Ser")) decreases p(HGNC:ATF6) + + + + + + + + + pubmed:21722302 + + complex(p(HGNC:ATF6), p(HGNC:VAPB)) decreases act(p(HGNC:ATF6)) + + + + + + + pubmed:21722302 + + complex(p(HGNC:ATF6), p(HGNC:VAPB, pmod(go:0016567 ! "protein ubiquitination"), var("p.Pro56Ser"))) decreases act(p(HGNC:ATF6)) + + + + + + + pubmed:21722302 + + p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination")) biomarkerFor path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:22908190 + + p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination")) positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:22908190 + + p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination")) positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination")) association path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:21722302 + + p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination")) biomarkerFor path(MESH:"Frontotemporal Lobar Degeneration") + + + + + + + pubmed:22908190 + + p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination")) positiveCorrelation path(MESH:"Frontotemporal Lobar Degeneration") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination")) association path(MESH:"Frontotemporal Lobar Degeneration") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination"), loc(GO:"inclusion body")) association path(MESH:"Lewy Body Disease") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination"), loc(GO:"inclusion body")) association path(MESH:"Supranuclear Palsy, Progressive") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination"), loc(GO:"inclusion body")) association path(MESH:"Pick Disease of the Brain") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination"), loc(GO:"inclusion body")) association path(MESH:Sclerosis) + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination"), loc(GO:"inclusion body")) association path(MESH:"Alzheimer Disease") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination"), loc(GO:"inclusion body")) association path(MESH:"Huntington Disease") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination"), loc(GO:"inclusion body")) association path(MESH:"Parkinson Disease") + + + + + + + pubmed:21722302 + + path(DOID:"variant Creutzfeldt-Jakob disease") isA path(DOID:"prion disease") + + + + + + + pubmed:21722302 + + path(DOID:"variant Creutzfeldt-Jakob disease") isA path(DOID:"neurodegenerative disease") + + + + + + + pubmed:21722302 + + path(DOID:"variant Creutzfeldt-Jakob disease") increases path(MESH:"Spongiform Encephalopathy with Neuropsychiatric Features") + + + + + + + pubmed:21722302 + + path(DOID:"variant Creutzfeldt-Jakob disease") increases bp(CONSO:"protein aggregation") + + + + + + + pubmed:27181519 + + path(DOID:"prion disease") association p(MESH:Proteins, pmod(CONSO:misfolded)) + + + + + + + pubmed:27181519 + + path(DOID:"prion disease") increases p(MESH:Proteins, pmod(CONSO:misfolded)) + + + + + + + pubmed:21722302 + + p(HGNC:PRNP, frag("106_126")) increases bp(MESH:Apoptosis) + + + + + + + pubmed:21722302 + + bp(GO:"neuron development") association p(HGNC:PRNP) + + + + + + + pubmed:18494933 + + bp(GO:"neuron development") negativeCorrelation act(p(HGNC:GSK3B)) + + + + + + + pubmed:16973293 + + bp(GO:"neuron development") positiveCorrelation p(CONSO:"MARK4 isoform 2 (688 aa)") + + + + + + + pubmed:30837838 + + bp(GO:"neuron development") association p(HGNC:TARDBP) + + + + + + + pubmed:30606258 + + p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) negativeCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:30606258 + + p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) negativeCorrelation act(p(HGNC:GSK3B)) + + + + + + + pubmed:30606258 + + p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) increases p(HGNC:GSK3B) + + + + + + + pubmed:30606258 + + p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) increases path(DOID:"cognitive disorder") + + + + + + + pubmed:30606258 + + p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) increases path(MESH:"Motor Disorders") + + + + + + + pubmed:30606258 + + p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) negativeCorrelation p(MESH:Proteins, loc(GO:"synaptic membrane")) + + + + + + + + + pubmed:30606258 + + p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) decreases composite(p(CONSO:"Tau isoform F (441 aa)", frag("187_441")), p(INTERPRO:"Alpha tubulin")) + + + + + + + pubmed:30606258 + + p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) increases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation", Lys, 40)) + + + + + + + pubmed:30606258 + + p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) decreases bp(GO:"cytoskeleton organization") + + + + + + + pubmed:30606258 + + p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) decreases bp(GO:"microtubule bundle formation") + + + + + + + pubmed:30606258 + + act(p(CONSO:"Tau isoform F (441 aa)", frag("187_441")), ma(GO:"microtubule binding")) negativeCorrelation p(CONSO:"Tau isoform F (441 aa)", frag("187_441"), pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + + + pubmed:30606258 + + p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) decreases act(p(HGNC:AKT1)) + + + + + + + pubmed:30606258 + + p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) decreases act(p(HGNC:AKT1)) + + + + + + + pubmed:30606258 + + p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) negativeCorrelation act(p(HGNC:INS)) + + + + + + + pubmed:30606258 + + p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) increases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + + + pubmed:30606258 + + p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) increases act(p(HGNCGENEFAMILY:"MTOR complex 1")) + + + + + + + pubmed:30606258 + + p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) increases act(p(HGNC:RPS6KB1)) + + + + + + + pubmed:30606258 + + p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) increases p(HGNC:IRS1, pmod(go:0006468 ! "protein phosphorylation", Ser, 636)) + + + + + + + pubmed:30606258 + + p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) increases p(HGNC:IRS1, pmod(go:0006468 ! "protein phosphorylation", Ser, 639)) + + + + + + + pubmed:30606258 + + p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) increases p(HGNC:EIF2AK3, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:30606258 + + p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) increases act(p(HGNC:EIF2AK3)) + + + + + + + pubmed:30606258 + + p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) increases bp(GO:"PERK-mediated unfolded protein response") + + + + + + + pubmed:30606258 + + p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) increases p(HGNC:ATF6, frag("?")) + + + + + + + pubmed:30606258 + + p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) increases bp(GO:"ATF6-mediated unfolded protein response") + + + + + + + pubmed:30606258 + + p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) causesNoChange p(HGNC:ERN1, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:30606258 + + p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) causesNoChange bp(GO:"IRE1-mediated unfolded protein response") + + + + + + + pubmed:30606258 + + p(CONSO:"Tau isoform F (441 aa)", frag("187_441")) increases p(HGNCGENEFAMILY:"CCAAT/enhancer binding proteins") + + + + + + + + + + + pubmed:30606258 + + complex(a(MESH:Microtubules), p(CONSO:"Tau isoform F (441 aa)")) increases bp(GO:"microtubule cytoskeleton organization") + + + + + + + pubmed:30606258 + + p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation", Lys, 40)) causesNoChange act(p(CONSO:"Tau isoform F (441 aa)", frag("187_441")), ma(GO:"microtubule binding")) + + + + + + + pubmed:30606258 + + p(NCIT:C17421) increases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation", Lys, 40)) + + + + + + + pubmed:30606258 + + p(NCIT:C17421) decreases p(HGNC:ATF6, frag("?")) + + + + + + + pubmed:30606258 + + p(NCIT:C17421) causesNoChange p(HGNC:ERN1, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:30606258 + + p(NCIT:C17421) causesNoChange bp(GO:"IRE1-mediated unfolded protein response") + + + + + + + pubmed:30606258 + + p(HGNC:ATAT1) increases p(INTERPRO:"Alpha tubulin", pmod(go:0006473 ! "protein acetylation", Lys, 40)) + + + + + + + + + pubmed:30606258 + + composite(p(CONSO:"Tau isoform F (441 aa)"), p(HGNC:ATAT1)) increases bp(GO:"microtubule bundle formation") + + + + + + + pubmed:30606258 + + p(CONSO:"Tau isoform F (441 aa)", frag("187_441"), pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation act(p(CONSO:"Tau isoform F (441 aa)", frag("187_441")), ma(GO:"microtubule binding")) + + + + + + + pubmed:30606258 + + a(CHEBI:"lithium chloride") decreases p(HGNC:GSK3A) + + + + + + + pubmed:30606258 + + a(CHEBI:"lithium chloride") decreases p(CONSO:"Tau isoform F (441 aa)", frag("187_441"), pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) + + + + + + + pubmed:30606258 + + a(CHEBI:"lithium chloride") decreases p(CONSO:"Tau isoform F (441 aa)", frag("187_441"), pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + + + + + + + pubmed:30606258 + + a(CHEBI:"lithium chloride") causesNoChange complex(a(MESH:Microtubules), p(CONSO:"Tau isoform F (441 aa)", frag("187_441"))) + + + + + + + pubmed:30606258 + + a(CHEBI:"lithium chloride") causesNoChange bp(GO:"microtubule polymerization or depolymerization") + + + + + + + pubmed:30606258 + + bp(GO:"regulation of insulin receptor signaling pathway") association act(p(HGNC:AKT1)) + + + + + + + pubmed:30606258 + + bp(GO:"regulation of insulin receptor signaling pathway") association p(HGNC:GSK3B) + + + + + + + pubmed:30606258 + + p(HGNC:RPS6KB1, pmod(go:0006468 ! "protein phosphorylation", Thr, 398)) increases act(p(HGNC:RPS6KB1)) + + + + + + + + + pubmed:30606258 + + act(p(HGNC:RPS6KB1)) negativeCorrelation act(p(HGNC:INS)) + + + + + + + pubmed:30606258 + + act(p(HGNC:RPS6KB1)) increases p(HGNC:IRS1, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:30606258 + + act(p(HGNC:RPS6KB1)) increases p(HGNC:IRS1, pmod(go:0006468 ! "protein phosphorylation", Ser, 636)) + + + + + + + pubmed:30606258 + + act(p(HGNC:RPS6KB1)) increases p(HGNC:IRS1, pmod(go:0006468 ! "protein phosphorylation", Ser, 639)) + + + + + + + pubmed:30606258 + + act(p(HGNC:RPS6KB1)) increases p(HGNC:IRS1, pmod(go:0006468 ! "protein phosphorylation", Ser, 1101)) + + + + + + + pubmed:30606258 + + act(p(HGNC:RPS6KB1)) increases p(HGNC:IRS1, pmod(go:0006468 ! "protein phosphorylation", Ser, 1101)) + + + + + + + pubmed:17493042 + + p(HGNC:RPS6KB1) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser)) + + + + + + + + + pubmed:26702100 + + p(HGNC:RPS6KB1) association act(p(HGNCGENEFAMILY:"MTOR complex 1")) + + + + + + + + + pubmed:30606258 + + p(HGNC:IRS1, pmod(go:0006468 ! "protein phosphorylation")) decreases act(p(HGNC:INS)) + + + + + + + pubmed:30606258 + + composite(p(CONSO:"Tau isoform F (441 aa)", frag("187_441")), p(HGNCGENEFAMILY:"MTOR complex 1")) increases p(HGNC:RPS6KB1, pmod(go:0006468 ! "protein phosphorylation", Thr, 398)) + + + + + + + pubmed:30606258 + + composite(p(CONSO:"Tau isoform F (441 aa)"), p(HGNCGENEFAMILY:"MTOR complex 1")) causesNoChange p(HGNC:RPS6KB1, pmod(go:0006468 ! "protein phosphorylation", Thr, 398)) + + + + + + + pubmed:30740335 + + p(HGNC:EIF2S1, pmod(go:0006468 ! "protein phosphorylation")) decreases path(MESH:"Protein Biosynthesis") + + + + + + + pubmed:30740335 + + p(HGNC:EIF2S1, pmod(go:0006468 ! "protein phosphorylation")) decreases path(MESH:"Protein Biosynthesis") + + + + + + + pubmed:30740335 + + p(HGNC:EIF2S1, pmod(go:0006468 ! "protein phosphorylation")) decreases bp(GO:"protein secretion") + + + + + + + pubmed:30740335 + + p(HGNC:EIF2S1, pmod(go:0006468 ! "protein phosphorylation")) increases path(MESH:"Memory Disorders") + + + + + + + pubmed:30740335 + + p(HGNC:EIF2S1, pmod(go:0006468 ! "protein phosphorylation")) increases path(MESH:"Nerve Degeneration") + + + + + + + pubmed:30740335 + + p(HGNC:EIF2S1, pmod(go:0006468 ! "protein phosphorylation")) association path(MESH:"Long-Term Potentiation") + + + + + + + pubmed:25784053 + + p(HGNC:EIF2S1, pmod(go:0006468 ! "protein phosphorylation")) increases act(p(HGNC:EIF2S1), ma(GO:"translation regulator activity")) + + + + + + + pubmed:23702978 + + p(HGNC:EIF2S1, pmod(go:0006468 ! "protein phosphorylation")) decreases bp(GO:translation) + + + + + + + + + pubmed:30740335 + + p(HGNC:EIF2S1) isA a(MESH:"Neuroprotective Agents") + + + + + + + pubmed:25784053 + + act(p(HGNC:EIF2S1), ma(GO:"translation regulator activity")) increases p(HGNC:ATF4) + + + + + + + pubmed:30606258 + + p(HGNC:ATF6, frag("?")) increases bp(GO:"ATF6-mediated unfolded protein response") + + + + + + + pubmed:30606258 + + composite(a(CHEBI:thapsigargin), p(CONSO:"Tau isoform F (441 aa)", frag("187_441"))) increases act(p(HGNC:EIF2AK3)) + + + + + + + pubmed:30606258 + + composite(a(CHEBI:thapsigargin), p(CONSO:"Tau isoform F (441 aa)", frag("187_441"))) increases act(p(HGNC:ERN1)) + + + + + + + pubmed:30606258 + + composite(a(CHEBI:thapsigargin), p(CONSO:"Tau isoform F (441 aa)", frag("187_441"))) increases path(EFO:"Endoplasmic Reticulum Stress") + + + + + + + pubmed:30740335 + + path(MESH:"Unfolded Protein Response") association path(MESH:"Cell Survival") + + + + + + + pubmed:30740335 + + path(MESH:"Unfolded Protein Response") association bp(GO:"protein stabilization") + + + + + + + pubmed:30740335 + + path(MESH:"Unfolded Protein Response") increases path(MESH:Homeostasis) + + + + + + + pubmed:30740335 + + path(MESH:"Unfolded Protein Response") increases path(MESH:"Organelle Biogenesis") + + + + + + + pubmed:30740335 + + path(MESH:"Unfolded Protein Response") increases bp(GO:"ERAD pathway") + + + + + + + pubmed:30740335 + + path(MESH:"Unfolded Protein Response") increases bp(GO:autophagy) + + + + + + + pubmed:30740335 + + path(MESH:"Unfolded Protein Response") association p(HGNC:HSPA5) + + + + + + + pubmed:30740335 + + path(MESH:"Unfolded Protein Response") increases act(p(HGNC:EIF2AK3)) + + + + + + + pubmed:30740335 + + bp(GO:"protein stabilization") association path(MESH:"Unfolded Protein Response") + + + + + + + pubmed:30740335 + + composite(a(MESH:"Endoplasmic Reticulum"), a(MESH:Mitochondria)) regulates bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") + + + + + + + pubmed:30740335 + + p(MESH:"Mutant Proteins") increases bp(GO:"ubiquitin-dependent protein catabolic process") + + + + + + + pubmed:30740335 + + p(MESH:"Mutant Proteins") increases bp(GO:"lysosomal protein catabolic process") + + + + + + + pubmed:14556719 + + bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"cell cycle") + + + + + + + pubmed:14556719 + + bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"cell division") + + + + + + + pubmed:14556719 + + bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"cell differentiation") + + + + + + + pubmed:14556719 + + bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(MESH:"Cell Proliferation") + + + + + + + pubmed:14556719 + + bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"cellular response to stress") + + + + + + + pubmed:14556719 + + bp(GO:"ubiquitin-dependent protein catabolic process") regulates a(MESH:"Receptors, Cell Surface") + + + + + + + pubmed:14556719 + + bp(GO:"ubiquitin-dependent protein catabolic process") regulates a(MESH:"Ion Channels") + + + + + + + pubmed:14556719 + + bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(MESH:"Secretory Pathway") + + + + + + + pubmed:14556719 + + bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"DNA repair") + + + + + + + pubmed:14556719 + + bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"gene silencing") + + + + + + + pubmed:14556719 + + bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"long-term memory") + + + + + + + pubmed:14556719 + + bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"circadian rhythm") + + + + + + + pubmed:14556719 + + bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"immune response") + + + + + + + pubmed:14556719 + + bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"inflammatory response") + + + + + + + pubmed:14556719 + + bp(GO:"ubiquitin-dependent protein catabolic process") regulates bp(GO:"organelle organization") + + + + + + + pubmed:30740335 + + bp(GO:"endoplasmic reticulum unfolded protein response") decreases path(HBP:proteotoxicity) + + + + + + + pubmed:30740335 + + p(MESH:Proteins, pmod(HBP:misfolded)) increases path(HBP:proteotoxicity) + + + + + + + pubmed:30740335 + + p(MESH:Proteins, pmod(HBP:misfolded), loc(GO:"endoplasmic reticulum")) decreases complex(p(HGNC:HSPA5)) + + + + + + + pubmed:30740335 + + bp(GO:"mitochondrial unfolded protein response") decreases path(HBP:proteotoxicity) + + + + + + + pubmed:30740335 + + path(MESH:"Protein Modification, Translational") increases path(MESH:"Protein Unfolding") + + + + + + + pubmed:30740335 + + bp(GO:"negative regulation of calcium ion transport") increases path(MESH:"Protein Unfolding") + + + + + + + pubmed:30740335 + + path(MESH:"Endoplasmic Reticulum Stress") association path(MESH:"Nervous System Diseases") + + + + + + + pubmed:30740335 + + path(MESH:"Endoplasmic Reticulum Stress") association path(MESH:"Diabetes Mellitus") + + + + + + + pubmed:30740335 + + path(MESH:"Endoplasmic Reticulum Stress") association path(MESH:Neoplasms) + + + + + + + pubmed:30740335 + + path(MESH:"Endoplasmic Reticulum Stress") association path(MESH:"Heart Diseases") + + + + + + + pubmed:30740335 + + path(MESH:"Endoplasmic Reticulum Stress") association path(MESH:"Lung Diseases") + + + + + + + pubmed:30740335 + + path(MESH:"Endoplasmic Reticulum Stress") association path(MESH:"Kidney Diseases") + + + + + + + pubmed:30740335 + + path(MESH:"Endoplasmic Reticulum Stress") association p(HGNC:UCHL1) + + + + + + + pubmed:30740335 + + path(MESH:"Nervous System Diseases") association path(MESH:"Endoplasmic Reticulum Stress") + + + + + + + pubmed:30740335 + + path(MESH:"Heart Diseases") association path(MESH:"Endoplasmic Reticulum Stress") + + + + + + + pubmed:30740335 + + path(MESH:"Lung Diseases") association path(MESH:"Endoplasmic Reticulum Stress") + + + + + + + pubmed:30740335 + + p(HGNC:XBP1, frag("?")) regulates path(MESH:"Unfolded Protein Response") + + + + + + + pubmed:30740335 + + p(HGNC:XBP1, frag("?")) regulates bp(GO:"ERAD pathway") + + + + + + + pubmed:30837838 + + path(MESH:"Protein Biosynthesis") association p(HGNC:TARDBP) + + + + + + + pubmed:23746257 + + bp(GO:"protein secretion") association p(FPLX:HSP90) + + + + + + + pubmed:30740335 + + p(HGNC:PPP1R15A) decreases p(HGNC:EIF2S1, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:30740335 + + p(HGNC:PPP1R15A) increases path(MESH:"Protein Biosynthesis") + + + + + + + pubmed:30740335 + + p(HGNC:PPP1R15A) decreases bp(GO:"synaptic signaling") + + + + + + + pubmed:26142647 + + p(HGNC:PPP1R15A) regulates act(p(HGNC:PPP1CA)) + + + + + + + pubmed:30740335 + + composite(p(HGNC:ERN1), p(HGNC:XBP1)) increases bp(GO:"JNK cascade") + + + + + + + pubmed:30740335 + + p(HBP:"amyloid-beta aggregates") increases path(MESH:"Endoplasmic Reticulum Stress") + + + + + + + pubmed:30740335 + + p(HGNC:FOXO1) increases path(MESH:Autophagy) + + + + + + + pubmed:30116051 + + p(HGNC:FOXO1) increases bp(GO:macroautophagy) + + + + + + + pubmed:30740335 + + a(CHEBI:salubrinal) decreases p(HGNC:PPP1R15A) + + + + + + + + + pubmed:28803412 + + a(CHEBI:salubrinal) decreases bp(MESH:"Endoplasmic Reticulum Stress") + + + + + + + pubmed:28803412 + + a(CHEBI:salubrinal) decreases a(CONSO:CONSO00093) + + + + + + + pubmed:30740335 + + composite(a(CHEBI:salubrinal), p(HGNC:SNCA, pmod(HBP:misfolded))) increases p(HGNC:EIF2S1) + + + + + + + + + pubmed:30740335 + + bp(GO:"negative regulation of dopamine receptor signaling pathway") association p(HGNC:EIF2AK3) + + + + + + + pubmed:30740335 + + path(MESH:"Long-Term Potentiation") association p(HGNC:EIF2S1, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:30740335 + + p(NCBIGENE:74018, frag("?")) increases path(MESH:"Endoplasmic Reticulum Stress") + + + + + + + + + pubmed:30740335 + + a(CHEBI:Guanabenz) increases p(HGNC:EIF2S1, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:23746257 + + a(CHEBI:Guanabenz) decreases act(p(FPLX:ADRA2)) + + + + + + + pubmed:23746257 + + a(CHEBI:Guanabenz) decreases act(p(FPLX:EIF2B)) + + + + + + + pubmed:23746257 + + a(CHEBI:Guanabenz) increases p(FPLX:EIF2B, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:30740335 + + a(PUBCHEM:9561611) decreases p(HGNC:EIF2AK3) + + + + + + + pubmed:30740335 + + a(PUBCHEM:9561611) association a(MESH:"Neuroprotective Agents") + + + + + + + pubmed:30740335 + + a(PUBCHEM:9561611) increases path(MESH:"Behavior and Behavior Mechanisms") + + + + + + + pubmed:30740335 + + p(HGNC:USP14) increases deg(p(HGNC:HTT, pmod(HBP:misfolded))) + + + + + + + pubmed:30740335 + + p(HGNC:USP14) increases p(HGNC:ERN1) + + + + + + + + + pubmed:25784053 + + p(HGNC:USP14) decreases deg(p(HGNC:MAPT)) + + + + + + + pubmed:25784053 + + p(HGNC:USP14) decreases deg(p(HGNC:TARDBP)) + + + + + + + pubmed:25784053 + + p(HGNC:USP14) decreases act(p(FPLX:Proteasome)) + + + + + + + + + pubmed:26041011 + + act(p(HGNC:USP14)) decreases act(complex(GO:"proteasome complex")) + + + + + + + pubmed:30740335 + + p(HGNC:SIGMAR1) association bp(GO:"cellular response to stress") + + + + + + + pubmed:30740335 + + p(HGNC:SIGMAR1) regulates bp(GO:"calcium-mediated signaling") + + + + + + + pubmed:30740335 + + p(HGNC:SIGMAR1) regulates path(MESH:"Energy Metabolism") + + + + + + + pubmed:30740335 + + p(HGNC:SIGMAR1) regulates bp(GO:"cell redox homeostasis") + + + + + + + pubmed:30740335 + + p(HGNC:SIGMAR1) regulates path(MESH:"Unfolded Protein Response") + + + + + + + pubmed:30740335 + + p(HGNC:SIGMAR1) regulates bp(GO:"cytokine-mediated signaling pathway") + + + + + + + pubmed:30740335 + + p(DBSNP:rs2269577) association path(MESH:"Bipolar Disorder") + + + + + + + pubmed:27209302 + + a(CHEBI:chloroquine) decreases act(a(MESH:Lysosomes)) + + + + + + + pubmed:27209302 + + a(CHEBI:chloroquine) decreases deg(p(CONSO:"amyloid-beta fibrils")) + + + + + + + pubmed:25784053 + + a(CHEBI:chloroquine) decreases bp(GO:autophagy) + + + + + + + pubmed:25784053 + + a(CHEBI:chloroquine) increases a(CHEBI:N-retinylidene-N-retinylethanolamine) + + + + + + + pubmed:25784053 + + a(CHEBI:chloroquine) increases p(HGNC:MAP1LC3A) + + + + + + + pubmed:25784053 + + a(CHEBI:chloroquine) increases p(HGNC:SQSTM1) + + + + + + + pubmed:24027553 + + a(CHEBI:chloroquine) increases p(HGNC:MAPT) + + + + + + + pubmed:24027553 + + a(CHEBI:chloroquine) decreases deg(p(HGNC:MAPT)) + + + + + + + pubmed:27209302 + + a(CHEBI:leupeptin) decreases act(a(MESH:Lysosomes)) + + + + + + + pubmed:27209302 + + a(CHEBI:leupeptin) decreases deg(p(CONSO:"amyloid-beta fibrils")) + + + + + + + + + pubmed:23528736 + + a(CHEBI:leupeptin) decreases act(p(FPLX:Proteasome)) + + + + + + + pubmed:23528736 + + a(CHEBI:leupeptin) decreases deg(p(HGNC:MAPT)) + + + + + + + pubmed:27209302 + + a(CHEBI:phosphoramidon) decreases p(HGNC:MME) + + + + + + + pubmed:27209302 + + a(CHEBI:phosphoramidon) association deg(p(CONSO:"amyloid-beta fibrils")) + + + + + + + pubmed:27209302 + + p(HGNC:TFEB) increases deg(p(CONSO:"amyloid-beta oligomers")) + + + + + + + pubmed:27209302 + + p(HGNC:TFEB) increases bp(MESH:"Organelle Biogenesis") + + + + + + + pubmed:27209302 + + p(HGNC:TFEB) increases bp(GO:"microglial cell activation") + + + + + + + pubmed:27209302 + + tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) increases act(p(HGNC:TFEB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) + + + + + + + pubmed:26968346 + + p(HGNC:TFEB, loc(GO:cytoplasm)) decreases act(p(HGNC:TFEB)) + + + + + + + pubmed:26968346 + + tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) increases act(p(HGNC:TFEB)) + + + + + + + pubmed:30108137 + + act(p(HGNC:TFEB)) negativeCorrelation p(HGNC:TFEB, loc(GO:cytoplasm)) + + + + + + + pubmed:30108137 + + p(HGNC:TFEB, loc(GO:cytoplasm)) negativeCorrelation act(p(HGNC:TFEB)) + + + + + + + pubmed:30108137 + + p(HGNC:TFEB) increases tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) + + + + + + + pubmed:30108137 + + p(HGNC:TFEB, loc(GO:nucleus)) increases act(p(HGNC:TFEB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) + + + + + + + pubmed:26702100 + + act(p(HGNC:TFEB), ma(MESH:"Transcription, Genetic")) association p(HGNC:TFEB, loc(GO:nucleus)) + + + + + + + pubmed:26702100 + + p(HGNC:TFEB, loc(GO:nucleus)) association act(p(HGNC:TFEB), ma(MESH:"Transcription, Genetic")) + + + + + + + + + + + + + + + + + pubmed:27209302 + + p(HGNC:TFEB) increases a(MESH:Lysosomes) + + + + + + + pubmed:26968346 + + p(HGNC:TFEB) increases a(MESH:Lysosomes) + + + + + + + pubmed:26968346 + + p(HGNC:TFEB) increases tloc(a(MESH:Lysosomes), fromLoc(GO:"extracellular space"), toLoc(GO:cell)) + + + + + + + pubmed:26968346 + + p(HGNC:TFEB) increases tloc(a(MESH:Lysosomes), fromLoc(GO:cell), toLoc(GO:"extracellular space")) + + + + + + + pubmed:26968346 + + p(HGNC:TFEB) increases a(MESH:Lysosomes) + + + + + + + pubmed:26968346 + + tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) increases a(MESH:Lysosomes) + + + + + + + pubmed:30108137 + + p(HGNC:TFEB) increases a(MESH:Lysosomes) + + + + + + + pubmed:30108137 + + p(HGNC:TFEB) regulates act(a(MESH:Lysosomes)) + + + + + + + pubmed:30108137 + + p(HGNC:TFEB) increases a(MESH:Lysosomes) + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) increases a(MESH:Lysosomes) + + + + + + + pubmed:27299292 + + act(p(HGNC:TFEB)) increases act(a(MESH:Lysosomes)) + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) increases a(MESH:Lysosomes) + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) increases a(MESH:Lysosomes) + + + + + + + pubmed:30108137 + + act(p(HGNC:TFEB, loc(GO:nucleus))) decreases act(a(MESH:Lysosomes)) + + + + + + + pubmed:27209302 + + p(HGNC:TFEB) increases bp(GO:"lysosomal protein catabolic process") + + + + + + + pubmed:26968346 + + p(HGNC:TFEB) increases bp(GO:"lysosomal protein catabolic process") + + + + + + + + + pubmed:27209302 + + act(p(HGNC:TFEB)) increases complex(g(HGNC:CLCN7), p(HGNC:TFEB)) + + + + + + + pubmed:26968346 + + p(HGNC:TFEB) positiveCorrelation path(DOID:"renal carcinoma") + + + + + + + pubmed:26968346 + + p(HGNC:TFEB) regulates bp(GO:autophagy) + + + + + + + pubmed:26968346 + + p(HGNC:TFEB) increases bp(GO:autophagy) + + + + + + + pubmed:27299292 + + act(p(HGNC:TFEB)) positiveCorrelation bp(GO:autophagy) + + + + + + + pubmed:27299292 + + act(p(HGNC:TFEB)) increases bp(GO:autophagy) + + + + + + + pubmed:27299292 + + act(p(HGNC:TFEB)) increases bp(GO:autophagy) + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) positiveCorrelation bp(GO:autophagy) + + + + + + + pubmed:27299292 + + act(p(HGNC:TFEB)) increases bp(GO:autophagy) + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) increases bp(GO:autophagy) + + + + + + + pubmed:29758300 + + p(HGNC:TFEB) regulates bp(GO:autophagy) + + + + + + + pubmed:29758300 + + p(HGNC:TFEB) increases bp(GO:autophagy) + + + + + + + pubmed:29626319 + + p(HGNC:TFEB) increases bp(GO:autophagy) + + + + + + + pubmed:26702100 + + p(HGNC:TFEB) regulates bp(GO:autophagy) + + + + + + + pubmed:26702100 + + act(p(HGNC:TFEB), ma(MESH:"Transcription, Genetic")) regulates bp(GO:autophagy) + + + + + + + pubmed:26968346 + + p(HGNC:TFEB) regulates bp(GO:"membrane assembly") + + + + + + + pubmed:26968346 + + p(HGNC:TFEB) positiveCorrelation bp(GO:"autophagosome organization") + + + + + + + pubmed:26968346 + + p(HGNC:TFEB) positiveCorrelation bp(GO:"autophagosome-lysosome fusion") + + + + + + + pubmed:27299292 + + act(p(HGNC:TFEB)) increases bp(GO:"autophagosome-lysosome fusion") + + + + + + + pubmed:26968346 + + p(HGNC:TFEB) increases act(p(HGNC:MCOLN1)) + + + + + + + pubmed:27299292 + + act(p(HGNC:TFEB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases act(p(HGNC:MCOLN1, loc(MESH:Lysosomes))) + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) increases p(HGNC:MCOLN1) + + + + + + + pubmed:26968346 + + p(HGNC:TFEB) regulates bp(GO:"apoptotic cell clearance") + + + + + + + pubmed:26968346 + + p(HGNC:TFEB) regulates bp(MESH:Metabolism) + + + + + + + pubmed:26968346 + + p(HGNC:TFEB) increases bp(GO:"mRNA transcription") + + + + + + + + + + + + + + + + + + + pubmed:26968346 + + p(HGNC:TFEB) decreases p(CONSO:"huntingtin aggregates") + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) decreases p(CONSO:"huntingtin aggregates") + + + + + + + pubmed:26968346 + + p(HGNC:TFEB) increases p(HGNC:PPARGC1A) + + + + + + + pubmed:27299292 + + act(p(HGNC:TFEB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases p(HGNC:PPARGC1A) + + + + + + + pubmed:26968346 + + p(HGNC:TFEB) decreases act(p(HGNC:SNCA, var("?"))) + + + + + + + pubmed:26968346 + + tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) decreases act(p(HGNC:SNCA, var("?"))) + + + + + + + + + pubmed:26968346 + + tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) decreases bp(GO:"cell death") + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) decreases bp(GO:"cell death") + + + + + + + pubmed:26968346 + + p(HGNC:TFEB) association bp(GO:mitophagy) + + + + + + + pubmed:27299292 + + act(p(HGNC:TFEB)) increases bp(GO:mitophagy) + + + + + + + + + pubmed:26968346 + + p(HGNC:TFEB) decreases act(p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) + + + + + + + pubmed:30108137 + + p(HGNC:TFEB) causesNoChange p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:27299292 + + act(p(HGNC:TFEB)) increases deg(p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) + + + + + + + pubmed:26968346 + + p(HGNC:TFEB) decreases path(DOID:"neurodegenerative disease") + + + + + + + pubmed:27299292 + + act(p(HGNC:TFEB)) negativeCorrelation path(DOID:"neurodegenerative disease") + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) negativeCorrelation path(DOID:"neurodegenerative disease") + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) decreases path(DOID:"neurodegenerative disease") + + + + + + + pubmed:26968346 + + p(HGNC:TFEB) positiveCorrelation bp(GO:behavior) + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) positiveCorrelation bp(GO:behavior) + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) positiveCorrelation bp(GO:behavior) + + + + + + + pubmed:26968346 + + p(HGNC:TFEB) increases p(HGNC:PTEN) + + + + + + + pubmed:27299292 + + act(p(HGNC:TFEB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases p(HGNC:PTEN) + + + + + + + pubmed:29758300 + + p(HGNC:TFEB) increases act(p(HGNC:PTEN)) + + + + + + + pubmed:26968346 + + p(HGNC:TFEB) decreases path(MESH:"Plaque, Amyloid") + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) decreases path(MESH:"Plaque, Amyloid") + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) negativeCorrelation path(MESH:"Plaque, Amyloid") + + + + + + + pubmed:30116051 + + p(HGNC:TFEB) decreases path(MESH:"Plaque, Amyloid") + + + + + + + pubmed:29626319 + + p(HGNC:TFEB) decreases path(MESH:"Plaque, Amyloid") + + + + + + + pubmed:26968346 + + p(HGNC:TFEB) increases act(p(MESH:Lysosomes)) + + + + + + + pubmed:26968346 + + p(HGNC:TFEB, loc(GO:nucleus)) increases deg(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) increases tloc(a(CHEBI:amyloid-beta), fromLoc(GO:cytoplasm), toLoc(MESH:Astrocytes)) + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) decreases a(CHEBI:amyloid-beta) + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) decreases a(CHEBI:amyloid-beta) + + + + + + + pubmed:29626319 + + p(HGNC:TFEB) decreases a(CHEBI:amyloid-beta) + + + + + + + pubmed:29626319 + + p(HGNC:TFEB) increases deg(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:29626319 + + p(HGNC:TFEB) regulates deg(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:26968346 + + p(HGNC:TFEB, loc(GO:nucleus)) increases p(MESH:Enzymes) + + + + + + + pubmed:30108137 + + act(p(HGNC:TFEB)) association path(MESH:"Stress, Physiological") + + + + + + + pubmed:30108137 + + act(p(HGNC:TFEB)) association p(CONSO:"protein aggregates") + + + + + + + pubmed:30108137 + + p(HGNC:TFEB, loc(GO:nucleus)) association path(DOID:"lysosomal storage disease") + + + + + + + pubmed:30108137 + + p(HGNC:TFEB) increases p(HGNC:LAMP1) + + + + + + + pubmed:30108137 + + p(HGNC:TFEB) increases p(HGNC:LAMP1) + + + + + + + pubmed:30108137 + + p(HGNC:TFEB) increases p(HGNC:LAMP1) + + + + + + + pubmed:30108137 + + p(HGNC:TFEB) increases p(HGNC:CTSD) + + + + + + + pubmed:30108137 + + p(HGNC:TFEB) increases p(HGNC:CTSD) + + + + + + + pubmed:30108137 + + p(HGNC:TFEB) increases act(p(HGNC:CTSD), ma(GO:"peptidase activity")) + + + + + + + pubmed:30108137 + + p(HGNC:TFEB) increases p(HGNC:CTSB) + + + + + + + pubmed:30108137 + + p(HGNC:TFEB) increases complex(GO:"late endosome") + + + + + + + pubmed:30108137 + + p(HGNC:TFEB) increases bp(GO:phagocytosis) + + + + + + + + + + + + + pubmed:30108137 + + p(HGNC:TFEB) increases r(HGNC:LAMP1) + + + + + + + pubmed:30108137 + + p(HGNC:TFEB) positiveCorrelation bp(GO:"lysosomal lumen acidification") + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) regulates bp(GO:"lysosomal lumen acidification") + + + + + + + pubmed:30108137 + + p(HGNC:TFEB) increases p(CONSO:"Tau fibrils", loc(MESH:Lysosomes)) + + + + + + + pubmed:30108137 + + p(HGNC:TFEB) increases p(CONSO:"Tau fibrils", loc(MESH:Lysosomes)) + + + + + + + pubmed:30108137 + + p(HGNC:TFEB) increases deg(p(CONSO:"Tau fibrils")) + + + + + + + pubmed:30108137 + + p(HGNC:TFEB) decreases p(CONSO:"Tau fibrils") + + + + + + + pubmed:30108137 + + p(HGNC:TFEB, loc(MESH:Astrocytes)) causesNoChange bp(GO:"excitatory postsynaptic potential") + + + + + + + pubmed:30108137 + + p(HGNC:TFEB, loc(MESH:Astrocytes)) causesNoChange bp(GO:"astrocyte activation") + + + + + + + pubmed:30108137 + + p(HGNC:TFEB, loc(MESH:Astrocytes)) causesNoChange act(a(MESH:Neurons)) + + + + + + + pubmed:30108137 + + p(HGNC:TFEB) causesNoChange p(HGNC:MAPT) + + + + + + + pubmed:30108137 + + p(HGNC:TFEB) decreases p(HGNC:MAPT) + + + + + + + pubmed:30108137 + + p(HGNC:TFEB) causesNoChange p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:30108137 + + p(HGNC:TFEB) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:30108137 + + p(HGNC:TFEB) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:30108137 + + p(HGNC:TFEB, loc(MESH:Astrocytes)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:30108137 + + p(HGNC:TFEB) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:29758300 + + p(HGNC:TFEB) increases deg(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) + + + + + + + pubmed:29626319 + + p(HGNC:TFEB) regulates deg(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) + + + + + + + pubmed:30108137 + + p(HGNC:TFEB) causesNoChange bp(GO:"reactive gliosis") + + + + + + + pubmed:30108137 + + p(HGNC:TFEB) decreases bp(GO:"reactive gliosis") + + + + + + + pubmed:30108137 + + p(HGNC:TFEB) causesNoChange bp(GO:"reactive gliosis") + + + + + + + pubmed:30108137 + + p(HGNC:TFEB) increases complex(GO:"hippocampal mossy fiber to CA3 synapse") + + + + + + + pubmed:30108137 + + p(HGNC:TFEB) decreases path(DOID:tauopathy) + + + + + + + pubmed:30108137 + + p(HGNC:TFEB) decreases complex(GO:"neurofibrillary tangle") + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) decreases complex(GO:"neurofibrillary tangle") + + + + + + + pubmed:30108137 + + p(HGNC:TFEB) decreases path(CONSO:"Pathological Tau Spreading") + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) regulates deg(a(CHEBI:hemoglobin)) + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) regulates deg(a(CHEBI:chitin)) + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) regulates bp(GO:exocytosis) + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) regulates bp(GO:endocytosis) + + + + + + + pubmed:27299292 + + act(p(HGNC:TFEB)) increases bp(GO:"autophagosome assembly") + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) increases bp(GO:"autophagosome assembly") + + + + + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) positiveCorrelation bp(GO:"lipid catabolic process") + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) positiveCorrelation bp(GO:"lipid oxidation") + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) negativeCorrelation bp(GO:"lipid biosynthetic process") + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) positiveCorrelation bp(GO:"protein transport") + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) positiveCorrelation bp(GO:"protein maturation") + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) regulates bp(MESH:Proteostasis) + + + + + + + + + + + + + + + + + + + pubmed:27299292 + + deg(p(HGNC:TFEB)) positiveCorrelation bp(GO:"chaperone-mediated autophagy") + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) association bp(GO:macroautophagy) + + + + + + + pubmed:30116051 + + p(HGNC:TFEB) increases bp(GO:macroautophagy) + + + + + + + pubmed:30116051 + + tloc(p(HGNC:TFEB), fromLoc(MESH:Cytoplasm), toLoc(MESH:"Cell Nucleus")) increases bp(GO:macroautophagy) + + + + + + + pubmed:27299292 + + act(p(HGNC:TFEB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases p(HGNC:FLCN) + + + + + + + pubmed:27299292 + + act(p(HGNC:TFEB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases p(HGNC:FNIP1) + + + + + + + pubmed:27299292 + + act(p(HGNC:TFEB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases p(HGNC:FNIP2) + + + + + + + pubmed:27299292 + + act(p(HGNC:TFEB)) association p(HGNC:EIF2AK3) + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) association p(HGNC:ATF4) + + + + + + + + + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) decreases p(CONSO:"alpha-synuclein oligomers") + + + + + + + pubmed:27299292 + + p(HGNC:TFEB, loc(GO:nucleus)) increases bp(MESH:Neuroprotection) + + + + + + + pubmed:27299292 + + act(p(HGNC:TFEB)) directlyIncreases bp(GO:"catabolic process") + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) increases bp(GO:"calcium ion regulated lysosome exocytosis") + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) increases bp(GO:"calcium ion regulated lysosome exocytosis") + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) increases bp(GO:"glycosaminoglycan catabolic process") + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) decreases bp(GO:"inflammatory response") + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) decreases bp(GO:"programmed cell death") + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) negativeCorrelation bp(GO:"programmed cell death") + + + + + + + pubmed:27299292 + + act(p(HGNC:TFEB)) negativeCorrelation path(MESH:"Protein Aggregation, Pathological") + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) decreases path(DOID:"Huntington's disease") + + + + + + + pubmed:27299292 + + act(p(HGNC:TFEB)) increases p(HGNC:NFYA) + + + + + + + pubmed:27299292 + + act(p(HGNC:TFEB)) increases bp(GO:"nuclear protein quality control by the ubiquitin-proteasome system") + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) decreases path(CONSO:"mitochondrial dysfunction") + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) positiveCorrelation bp(GO:"neuron-neuron synaptic transmission") + + + + + + + pubmed:27299292 + + act(p(HGNC:TFEB)) increases deg(p(HGNC:MAPT, pmod(CONSO:misfolded))) + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) increases deg(p(HGNC:APP, var("?"))) + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) decreases p(HGNC:GSK3B) + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) negativeCorrelation path(DOID:neuropathy) + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) increases deg(p(HGNC:SERPINA1, var("?"))) + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) negativeCorrelation path(MESH:Fibrosis) + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) decreases p(HGNC:SERPINA1, pmod(CONSO:misfolded)) + + + + + + + pubmed:27299292 + + p(HGNC:TFEB) decreases p(HGNC:SERPINA1, pmod(CONSO:"protein aggregates")) + + + + + + + pubmed:29758300 + + p(HGNC:TFEB) regulates a(GO:lysosome) + + + + + + + pubmed:29626319 + + p(HGNC:TFEB) increases act(a(GO:lysosome)) + + + + + + + pubmed:29626319 + + p(HGNC:TFEB) increases act(a(GO:lysosome)) + + + + + + + pubmed:26702100 + + act(p(HGNC:TFEB), ma(MESH:"Transcription, Genetic")) regulates a(GO:lysosome) + + + + + + + pubmed:26702100 + + p(HGNC:TFEB) increases a(GO:lysosome) + + + + + + + pubmed:29758300 + + p(HGNC:TFEB) association path(MESH:"Alzheimer Disease") + + + + + + + + + + + pubmed:28803412 + + p(HGNC:TFEB) decreases a(CONSO:CONSO00093) + + + + + + + pubmed:30108137 + + act(p(HGNC:TFEB, loc(GO:nucleus))) increases a(CONSO:"protein aggregates") + + + + + + + pubmed:29626319 + + p(HGNC:TFEB) regulates deg(a(MESH:"Neurofibrillary Tangles")) + + + + + + + pubmed:28669544 + + p(HGNC:TFEB) regulates path(MESH:"Organelle Biogenesis") + + + + + + + pubmed:30837838 + + p(HGNC:TFEB) regulates path(MESH:Autophagy) + + + + + + + pubmed:30837838 + + p(HGNC:TFEB) association p(HGNC:TARDBP) + + + + + + + pubmed:26702100 + + p(HGNC:TFEB) association path(MESH:"Neurodegenerative Diseases") + + + + + + + + + + + + + + + pubmed:26702100 + + p(HGNC:TFEB, loc(GO:lysosome)) association p(HGNC:RRAGA) + + + + + + + pubmed:26702100 + + p(HGNC:TFEB) increases p(HGNC:MAP1LC3B) + + + + + + + pubmed:26702100 + + p(HGNC:TFEB) increases a(GO:autophagosome) + + + + + + + pubmed:27209302 + + r(HGNC:TFEB) increases bp(GO:"microglial cell activation") + + + + + + + + + pubmed:26968346 + + r(HGNC:TFEB) increases deg(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:26968346 + + r(HGNC:TFEB) increases p(MESH:Enzymes) + + + + + + + pubmed:30108137 + + r(HGNC:TFEB) association path(DOID:dementia) + + + + + + + pubmed:30108137 + + r(HGNC:TFEB) negativeCorrelation bp(GO:cognition) + + + + + + + pubmed:30108137 + + r(HGNC:TFEB) decreases bp(GO:cognition) + + + + + + + pubmed:30108137 + + r(HGNC:TFEB) positiveCorrelation a(CONSO:"Braak_Stage VI") + + + + + + + pubmed:30108137 + + r(HGNC:TFEB) increases p(HGNC:TFEB) + + + + + + + pubmed:27299292 + + r(HGNC:TFEB) increases p(HGNC:TFEB) + + + + + + + + + + + + + + + pubmed:30108137 + + r(HGNC:TFEB) positiveCorrelation path(MESH:"Cognitive Dysfunction") + + + + + + + pubmed:30108137 + + r(HGNC:TFEB) increases path(MESH:Dementia) + + + + + + + pubmed:27209302 + + p(HGNCGENEFAMILY:"MTOR complex 1", pmod(go:0006468 ! "protein phosphorylation")) decreases act(p(HGNCGENEFAMILY:"MTOR complex 1")) + + + + + + + pubmed:27209302 + + p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation")) decreases bp(GO:"microglial cell activation") + + + + + + + pubmed:27209302 + + p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation")) decreases bp(GO:"microglial cell activation") + + + + + + + pubmed:27209302 + + p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation")) decreases act(p(HGNC:TFEB)) + + + + + + + pubmed:27209302 + + p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation")) increases p(CONSO:"amyloid-beta aggregates") + + + + + + + pubmed:27209302 + + p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation")) increases path(MESH:"Plaque, Amyloid") + + + + + + + pubmed:27209302 + + p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation")) decreases a(MESH:Lysosomes) + + + + + + + pubmed:27209302 + + p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation")) decreases act(a(MESH:Lysosomes)) + + + + + + + pubmed:27209302 + + p(HGNC:HDAC4) decreases p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation")) + + + + + + + pubmed:27209302 + + p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation", Lys, 116)) regulates act(p(HGNC:TFEB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) + + + + + + + pubmed:27209302 + + p(HGNC:TFEB, var("p.Lys116Arg")) increases deg(p(CONSO:"amyloid-beta fibrils")) + + + + + + + pubmed:27209302 + + p(HGNC:TFEB, var("p.Lys116Arg")) causesNoChange deg(p(CONSO:"amyloid-beta fibrils")) + + + + + + + pubmed:27209302 + + p(HGNC:TFEB, var("p.Lys116Arg")) increases a(MESH:Lysosomes) + + + + + + + pubmed:27209302 + + p(HGNC:TFEB, var("p.Lys116Arg")) causesNoChange a(MESH:Lysosomes) + + + + + + + pubmed:27209302 + + p(HGNC:TFEB, var("p.Lys116Arg")) causesNoChange act(a(MESH:Lysosomes)) + + + + + + + pubmed:27209302 + + p(HGNC:TFEB, var("p.Lys116Arg")) increases act(p(HGNC:TFEB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) + + + + + + + pubmed:27209302 + + p(HGNC:TFEB, var("p.Lys116Arg")) increases act(p(HGNC:TFEB)) + + + + + + + pubmed:27209302 + + p(HGNC:TFEB, var("p.Lys116Arg")) increases deg(p(CONSO:"amyloid-beta aggregates")) + + + + + + + pubmed:27209302 + + composite(p(HGNC:SIRT1), p(HGNC:TFEB)) increases complex(p(HGNC:SIRT1), p(HGNC:TFEB)) + + + + + + + pubmed:27209302 + + p(HGNC:SIRT1, var("?")) increases p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation")) + + + + + + + pubmed:27209302 + + p(HGNC:SIRT1, var("?")) decreases act(p(HGNC:SIRT1)) + + + + + + + pubmed:27209302 + + p(HGNC:SIRT1, var("?")) decreases act(p(HGNC:SIRT1)) + + + + + + + pubmed:27209302 + + p(HGNC:SIRT1, var("?")) increases a(MESH:Lysosomes) + + + + + + + pubmed:27209302 + + p(HGNC:SIRT6) causesNoChange p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation")) + + + + + + + pubmed:27209302 + + p(HGNC:SIRT6) decreases p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation")) + + + + + + + + + + + pubmed:27209302 + + p(HGNC:SIRT7) causesNoChange p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation")) + + + + + + + pubmed:27209302 + + p(HGNC:SIRT7) decreases p(HGNC:TFEB, pmod(go:0006473 ! "protein acetylation")) + + + + + + + pubmed:27209302 + + composite(a(CHEBI:nicotinamide), a(MESH:Lysosomes)) decreases a(MESH:Lysosomes) + + + + + + + pubmed:27209302 + + complex(g(HGNC:CLCN7), p(HGNC:TFEB)) increases p(HGNC:CLCN7) + + + + + + + + + pubmed:26968346 + + path(DOID:"renal carcinoma") positiveCorrelation p(HGNC:TFEB) + + + + + + + pubmed:27299292 + + path(DOID:"renal carcinoma") positiveCorrelation path(DOID:"Birt-Hogg-Dube syndrome") + + + + + + + pubmed:26968346 + + bp(GO:"autophagosome organization") positiveCorrelation p(HGNC:TFEB) + + + + + + + pubmed:26968346 + + act(p(HGNC:MCOLN1)) increases tloc(a(MESH:Lysosomes), fromLoc(GO:cell), toLoc(GO:"extracellular space")) + + + + + + + pubmed:26968346 + + p(HGNC:MCOLN1) decreases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:26968346 + + p(HGNC:MCOLN1) increases complex(GO:"calcineurin complex") + + + + + + + + + pubmed:27299292 + + act(p(HGNC:MCOLN1, loc(MESH:Lysosomes))) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:30116051 + + act(p(HGNC:MCOLN1)) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:Lysosomes), toLoc(MESH:Cytoplasm)) + + + + + + + pubmed:27299292 + + p(HGNC:MCOLN1) increases bp(GO:"calcium ion import") + + + + + + + pubmed:30116051 + + act(p(HGNC:MCOLN1)) increases bp(GO:"lysosomal lumen acidification") + + + + + + + pubmed:30116051 + + act(p(HGNC:MCOLN1)) decreases a(CHEBI:amyloid-beta) + + + + + + + pubmed:26968346 + + bp(GO:"response to starvation") increases tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) + + + + + + + pubmed:26968346 + + bp(GO:"response to nutrient") increases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation", Ser, 142)) + + + + + + + pubmed:26968346 + + bp(GO:"response to nutrient") increases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation", Ser, 211)) + + + + + + + pubmed:26968346 + + bp(GO:"response to nutrient") increases tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) + + + + + + + pubmed:22908190 + + bp(GO:"response to nutrient") regulates p(HGNC:MTOR) + + + + + + + pubmed:27299292 + + p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation", Ser, 142)) decreases act(p(HGNC:TFEB)) + + + + + + + pubmed:27299292 + + p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation", Ser, 142)) increases p(HGNC:TFEB, loc(GO:cytoplasm)) + + + + + + + pubmed:27299292 + + p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation", Ser, 142)) decreases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) + + + + + + + pubmed:27299292 + + p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation", Ser, 211)) decreases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) + + + + + + + pubmed:27299292 + + p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation", Ser, 211)) increases composite(p(HGNC:TFEB), p(HGNC:YWHAQ)) + + + + + + + pubmed:26968346 + + p(HGNC:TFEB, var("p.Ser142Ala")) increases tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) + + + + + + + pubmed:26968346 + + p(HGNC:TFEB, var("p.Ser211Ala")) increases tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) + + + + + + + pubmed:26702100 + + p(HGNC:TFEB, var("p.Ser211Ala")) decreases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:26702100 + + p(HGNC:TFEB, var("p.Ser211Ala")) decreases complex(p(HGNC:TFEB), p(HGNCGENEFAMILY:"14-3-3 phospho-serine/phospho-threonine binding proteins")) + + + + + + + pubmed:26968346 + + complex(p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation")), p(HGNCGENEFAMILY:"14-3-3 phospho-serine/phospho-threonine binding proteins")) increases p(HGNCGENEFAMILY:"14-3-3 phospho-serine/phospho-threonine binding proteins", loc(GO:cytoplasm)) + + + + + + + + + pubmed:30108137 + + p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation")) increases p(HGNC:TFEB, loc(GO:cytoplasm)) + + + + + + + pubmed:27299292 + + p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation")) increases p(HGNC:TFEB, loc(GO:cytosol)) + + + + + + + pubmed:29758300 + + p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation")) decreases act(p(HGNC:TFEB)) + + + + + + + pubmed:26702100 + + p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation")) increases complex(p(HGNC:TFEB), p(HGNCGENEFAMILY:"14-3-3 phospho-serine/phospho-threonine binding proteins")) + + + + + + + + + + + pubmed:26968346 + + composite(a(MESH:"Amino Acids"), p(MESH:"Vacuolar Proton-Translocating ATPases")) regulates act(complex(GO:"Ragulator complex"), ma(GO:"GTPase activity")) + + + + + + + + + + + pubmed:26968346 + + act(complex(GO:"Ragulator complex"), ma(GO:"GTPase activity")) increases tloc(p(HGNCGENEFAMILY:"MTOR complex 1"), fromLoc(GO:cytoplasm), toLoc(GO:"lysosomal membrane")) + + + + + + + pubmed:27299292 + + complex(GO:"Ragulator complex") increases tloc(p(HGNCGENEFAMILY:"MTOR complex 1"), fromLoc(GO:cytoplasm), toLoc(GO:"plasma membrane")) + + + + + + + pubmed:27299292 + + complex(GO:"Ragulator complex") increases tloc(p(HGNCGENEFAMILY:"MTOR complex 1"), fromLoc(GO:cytoplasm), toLoc(GO:"plasma membrane")) + + + + + + + pubmed:27299292 + + complex(GO:"Ragulator complex") association act(p(HGNCGENEFAMILY:"MTOR complex 1")) + + + + + + + pubmed:27299292 + + act(complex(GO:"Ragulator complex")) increases p(HGNC:TFEB, loc(GO:cytoplasm)) + + + + + + + + + pubmed:26702100 + + complex(GO:"Ragulator complex") regulates act(p(HGNC:MTOR)) + + + + + + + pubmed:26968346 + + complex(p(HGNC:TFEB), p(HGNCGENEFAMILY:"MTOR complex 1"), loc(GO:"lysosomal membrane")) increases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:26968346 + + complex(p(HGNC:TFEB), p(HGNCGENEFAMILY:"MTOR complex 1"), loc(GO:"lysosomal membrane")) increases p(HGNC:TFEB, loc(GO:cytoplasm)) + + + + + + + pubmed:26968346 + + a(CHEBI:"torin 1") decreases p(HGNCGENEFAMILY:"MTOR complex 1") + + + + + + + pubmed:30108137 + + a(CHEBI:"torin 1") decreases p(HGNCGENEFAMILY:"MTOR complex 1") + + + + + + + pubmed:26968346 + + a(CHEBI:"torin 1") increases p(HGNC:TFEB, loc(GO:nucleus)) + + + + + + + pubmed:30108137 + + a(CHEBI:"torin 1") increases p(HGNC:TFEB, loc(GO:nucleus)) + + + + + + + pubmed:26702100 + + a(CHEBI:"torin 1") increases p(HGNC:TFEB, loc(GO:lysosome)) + + + + + + + pubmed:26702100 + + a(CHEBI:"torin 1") increases p(HGNC:TFEB, loc(GO:nucleus)) + + + + + + + pubmed:30108137 + + a(CHEBI:"torin 1") increases composite(p(HGNC:LAMP1), p(HGNC:TFEB)) + + + + + + + + + pubmed:30108137 + + a(CHEBI:"torin 1") decreases act(p(FPLX:mTORC1)) + + + + + + + + + pubmed:26702100 + + a(CHEBI:"torin 1") isA a(CHEBI:"mTOR inhibitor") + + + + + + + pubmed:26968346 + + complex(a(MESH:"Transcription Factors"), r(HGNC:TFEB)) increases p(HGNC:TFEB) + + + + + + + + + pubmed:26968346 + + composite(a(CHEBI:"calcium(2+)"), p(HGNC:MCOLN1)) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(GO:lysosome), toLoc(GO:cytoplasm)) + + + + + + + pubmed:26968346 + + complex(p(HGNC:HTT), p(HGNC:SQSTM1)) increases bp(GO:"selective autophagy") + + + + + + + pubmed:26968346 + + bp(GO:"selective autophagy") increases deg(p(HGNC:HTT)) + + + + + + + pubmed:26968346 + + bp(GO:"selective autophagy") association p(HGNC:HTT) + + + + + + + pubmed:26968346 + + composite(p(HGNC:HTT), p(HGNC:ULK1)) increases bp(GO:autophagy) + + + + + + + pubmed:26968346 + + bp(GO:"protein phosphorylation") regulates bp(GO:"chaperone-mediated autophagy") + + + + + + + pubmed:30985105 + + bp(GO:"protein phosphorylation") association p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) + + + + + + + pubmed:30985105 + + bp(GO:"protein phosphorylation") association p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) + + + + + + + pubmed:26968346 + + p(HGNC:HSPA8) increases deg(p(HGNC:HTT)) + + + + + + + pubmed:25437566 + + p(HGNC:HSPA8) decreases a(CHEBI:"amyloid-beta polypeptide 42") + + + + + + + pubmed:25437566 + + p(HGNC:HSPA8) increases bp(GO:"protein folding") + + + + + + + pubmed:25437566 + + p(HGNC:HSPA8) increases a(CONSO:"huntingtin aggregates") + + + + + + + pubmed:29758300 + + p(HGNC:HSPA8) increases deg(p(HGNC:MAPT)) + + + + + + + pubmed:21882945 + + act(p(HGNC:HSPA8), ma(GO:"ATPase activity")) decreases deg(p(HGNC:MAPT)) + + + + + + + pubmed:21882945 + + act(p(HGNC:HSPA8)) increases p(HGNC:MAPT) + + + + + + + + + + + pubmed:18930136 + + p(HGNC:HSPA8) association bp(GO:"chaperone-mediated autophagy") + + + + + + + + + pubmed:18930136 + + p(HGNC:HSPA8) increases complex(a(MESH:Proteins), p(HGNC:HSPA8)) + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + pubmed:24706768 + + p(HGNC:HSPA8) increases bp(GO:"clathrin-dependent endocytosis") + + + + + + + pubmed:24706768 + + p(HGNC:HSPA8) increases bp(GO:"clathrin-dependent endocytosis") + + + + + + + pubmed:24706768 + + p(HGNC:HSPA8) increases bp(GO:"clathrin coat disassembly") + + + + + + + + + + + + + pubmed:21882945 + + p(HGNC:HSPA8) regulates complex(a(GO:microtubule), p(HGNC:MAPT)) + + + + + + + + + + + pubmed:18500754 + + p(HGNC:HSPA8) association p(CONSO:"microtubule-binding region") + + + + + + + pubmed:18500754 + + act(p(HGNC:HSPA8)) negativeCorrelation act(complex(GO:microtubule)) + + + + + + + + + + + pubmed:17954934 + + p(HGNC:HSPA8) isA complex(p(HGNC:BAG1), p(HGNC:HSPA8), p(HGNC:MAPT)) + + + + + + + pubmed:26968346 + + p(HGNC:LAMP2) increases deg(p(HGNC:HTT)) + + + + + + + pubmed:30562574 + + p(HGNC:LAMP2, loc(GO:"lysosomal membrane")) increases tloc(a(MESH:Proteins), fromLoc(GO:cytoplasm), toLoc(GO:lysosome)) + + + + + + + pubmed:18930136 + + p(HGNC:LAMP2) increases tloc(a(MESH:Proteins), fromLoc(GO:intracellular), toLoc(GO:lysosome)) + + + + + + + pubmed:30562574 + + p(HGNC:LAMP2) regulates bp(GO:"chaperone-mediated autophagy") + + + + + + + pubmed:30562574 + + p(HGNC:LAMP2, loc(GO:cytoplasm)) decreases bp(GO:"chaperone-mediated autophagy") + + + + + + + pubmed:30562574 + + p(HGNC:LAMP2, loc(GO:"lysosomal membrane")) increases bp(GO:"chaperone-mediated autophagy") + + + + + + + pubmed:30562574 + + p(HGNC:LAMP2) increases bp(GO:"chaperone-mediated autophagy") + + + + + + + pubmed:30116051 + + p(HGNC:LAMP2) increases bp(GO:"chaperone-mediated autophagy") + + + + + + + pubmed:30562574 + + p(HGNC:LAMP2) negativeCorrelation bp(GO:aging) + + + + + + + pubmed:30562574 + + p(HGNC:LAMP2) regulates a(MESH:Proteome) + + + + + + + pubmed:30562574 + + p(HGNC:LAMP2) increases bp(GO:"lysosomal protein catabolic process") + + + + + + + pubmed:30562574 + + p(HGNC:LAMP2) causesNoChange bp(GO:macroautophagy) + + + + + + + pubmed:30562574 + + p(HGNC:LAMP2) causesNoChange p(HGNC:MAP1LC3A, pmod(GO:"protein lipidation")) + + + + + + + pubmed:30562574 + + p(HGNC:LAMP2) causesNoChange p(HGNC:SQSTM1) + + + + + + + pubmed:30562574 + + p(HGNC:LAMP2) causesNoChange path(MESH:"Cytotoxicity, Immunologic") + + + + + + + pubmed:30562574 + + p(HGNC:LAMP2) causesNoChange bp(GO:"cell death") + + + + + + + pubmed:30562574 + + p(HGNC:LAMP2) causesNoChange p(HGNC:TUBB3) + + + + + + + pubmed:30562574 + + p(HGNC:LAMP2) causesNoChange p(HGNC:TUBB3) + + + + + + + pubmed:30562574 + + p(HGNC:LAMP2) causesNoChange p(HGNC:MAP2) + + + + + + + pubmed:30562574 + + p(HGNC:LAMP2) increases p(HGNC:MAP2) + + + + + + + pubmed:30562574 + + p(HGNC:LAMP2) decreases p(HGNC:GAPDH) + + + + + + + pubmed:30562574 + + p(HGNC:LAMP2) decreases p(HGNC:PHB) + + + + + + + pubmed:30562574 + + deg(p(HGNC:LAMP2)) causesNoChange r(HGNC:PARK7) + + + + + + + pubmed:30562574 + + deg(p(HGNC:LAMP2)) increases deg(p(HGNC:PARK7)) + + + + + + + pubmed:30562574 + + p(HGNC:LAMP2) increases p(HGNC:PARK7) + + + + + + + + + pubmed:30562574 + + deg(p(HGNC:LAMP2)) causesNoChange r(HGNC:DPYSL2) + + + + + + + pubmed:30562574 + + deg(p(HGNC:LAMP2)) increases deg(p(HGNC:DPYSL2)) + + + + + + + pubmed:30562574 + + p(HGNC:LAMP2) increases p(HGNC:DPYSL2) + + + + + + + pubmed:30562574 + + p(HGNC:LAMP2) increases p(HGNC:DPYSL2) + + + + + + + pubmed:30562574 + + p(HGNC:LAMP2) increases p(HGNC:DPYSL2) + + + + + + + pubmed:30562574 + + act(p(HGNC:LAMP2)) regulates a(GO:dendrite) + + + + + + + pubmed:30562574 + + act(p(HGNC:LAMP2)) causesNoChange bp(GO:"neuron projection development") + + + + + + + + + + + + + + + pubmed:30116051 + + p(HGNC:LAMP2) increases deg(p(HGNC:SNCA)) + + + + + + + pubmed:26968346 + + a(CHEBI:Temsirolimus) positiveCorrelation bp(GO:autophagy) + + + + + + + pubmed:29626319 + + a(CHEBI:Temsirolimus) increases bp(GO:autophagy) + + + + + + + pubmed:26968346 + + a(CHEBI:Temsirolimus) increases deg(p(HGNC:HTT, pmod(CONSO:"CAG repeats"))) + + + + + + + pubmed:27299292 + + a(CHEBI:Temsirolimus) increases a(CHEBI:sirolimus) + + + + + + + pubmed:27299292 + + a(CHEBI:Temsirolimus) decreases act(p(HGNCGENEFAMILY:"MTOR complex 1")) + + + + + + + pubmed:27299292 + + a(CHEBI:Temsirolimus) increases tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) + + + + + + + pubmed:27299292 + + a(CHEBI:Temsirolimus) increases bp(MESH:Neuroprotection) + + + + + + + pubmed:29758300 + + a(CHEBI:Temsirolimus) increases bp(GO:macroautophagy) + + + + + + + pubmed:30116051 + + a(CHEBI:Temsirolimus) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:29626319 + + a(CHEBI:Temsirolimus) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:30116051 + + a(CHEBI:Temsirolimus) decreases a(CONSO:"huntingtin aggregates") + + + + + + + pubmed:30116051 + + a(CHEBI:Temsirolimus) increases bp(GO:"motor behavior") + + + + + + + pubmed:30116051 + + a(CHEBI:Temsirolimus) decreases a(CONSO:"alpha-synuclein aggregates") + + + + + + + pubmed:30116051 + + a(CHEBI:Temsirolimus) decreases bp(HP:Neurodegeneration) + + + + + + + pubmed:30116051 + + a(CHEBI:Temsirolimus) decreases p(HGNC:ATXN3, var("?")) + + + + + + + pubmed:29626319 + + a(CHEBI:Temsirolimus) decreases a(CHEBI:amyloid-beta) + + + + + + + pubmed:26968346 + + bp(GO:"nervous system process") positiveCorrelation p(HGNC:PPARGC1A) + + + + + + + pubmed:26968346 + + bp(GO:"regulation of ER to Golgi vesicle-mediated transport") negativeCorrelation p(CONSO:"alpha-synuclein aggregates") + + + + + + + pubmed:26968346 + + bp(GO:"regulation of ER to Golgi vesicle-mediated transport") positiveCorrelation bp(GO:autophagy) + + + + + + + pubmed:26968346 + + bp(GO:"regulation of ER to Golgi vesicle-mediated transport") association p(HGNC:RAB1A) + + + + + + + pubmed:26968346 + + p(HGNC:RAB1A) association bp(GO:"regulation of ER to Golgi vesicle-mediated transport") + + + + + + + pubmed:26968346 + + p(HGNC:RAB1A) regulates bp(GO:macroautophagy) + + + + + + + pubmed:26968346 + + p(HGNC:RAB1A) decreases p(CONSO:"alpha-synuclein aggregates") + + + + + + + pubmed:26968346 + + p(HGNC:RAB1A) positiveCorrelation bp(GO:autophagy) + + + + + + + pubmed:27181519 + + p(HGNC:RAB1A) increases bp(GO:autophagy) + + + + + + + pubmed:25784053 + + p(HGNC:RAB1A) increases bp(GO:"autophagosome assembly") + + + + + + + pubmed:29238289 + + p(HGNC:RAB1A) association tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:27181519 + + p(HGNC:RAB1A) increases deg(p(HGNC:FUS, pmod(CONSO:"protein aggregation"))) + + + + + + + pubmed:27181519 + + p(HGNC:RAB1A) association g(HGNC:C9orf72) + + + + + + + pubmed:27299292 + + bp(GO:macroautophagy) association p(HGNC:TFEB) + + + + + + + pubmed:30562574 + + bp(GO:macroautophagy) increases tloc(a(MESH:"Cytoplasmic Vesicles"), fromLoc(GO:cytoplasm), toLoc(GO:lysosome)) + + + + + + + pubmed:30562574 + + bp(GO:macroautophagy) negativeCorrelation bp(GO:"chaperone-mediated autophagy") + + + + + + + pubmed:29758300 + + bp(GO:macroautophagy) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:29758300 + + bp(GO:macroautophagy) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:29758300 + + bp(GO:macroautophagy) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:29758300 + + bp(GO:macroautophagy) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:25784053 + + bp(GO:macroautophagy) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:29758300 + + bp(GO:macroautophagy) increases deg(a(CONSO:"protein aggregates")) + + + + + + + pubmed:29758300 + + bp(GO:macroautophagy) increases deg(a(CONSO:"protein aggregates")) + + + + + + + pubmed:27181519 + + bp(GO:macroautophagy) increases deg(a(CONSO:"protein aggregates")) + + + + + + + pubmed:29758300 + + bp(GO:macroautophagy) regulates bp(GO:"amyloid-beta metabolic process") + + + + + + + pubmed:29758300 + + bp(GO:macroautophagy) negativeCorrelation a(CHEBI:amyloid-beta) + + + + + + + pubmed:29758300 + + bp(GO:macroautophagy) increases deg(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:29758300 + + bp(GO:macroautophagy) regulates a(CHEBI:amyloid-beta) + + + + + + + pubmed:29758300 + + bp(GO:macroautophagy) increases tloc(a(CHEBI:amyloid-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:29758300 + + bp(GO:macroautophagy) increases tloc(a(CHEBI:amyloid-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:29758300 + + bp(GO:macroautophagy) association p(HGNC:BECN1) + + + + + + + pubmed:29758300 + + bp(GO:macroautophagy) increases path(MESH:"Plaque, Amyloid") + + + + + + + pubmed:29758300 + + bp(GO:macroautophagy) increases deg(a(CONSO:"Tau aggregates")) + + + + + + + pubmed:29758300 + + bp(GO:macroautophagy) increases deg(a(CHEBI:triglyceride)) + + + + + + + pubmed:29758300 + + bp(GO:macroautophagy) negativeCorrelation path(MESH:"Parkinson Disease") + + + + + + + pubmed:29758300 + + bp(GO:macroautophagy) negativeCorrelation path(MESH:"Niemann-Pick Disease, Type C") + + + + + + + pubmed:29758300 + + bp(GO:macroautophagy) negativeCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:29758300 + + bp(GO:macroautophagy) negativeCorrelation path(MESH:"Bulbo-Spinal Atrophy, X-Linked") + + + + + + + pubmed:29758300 + + bp(GO:macroautophagy) negativeCorrelation path(MESH:"Spastic Paraplegia, Hereditary") + + + + + + + pubmed:22908190 + + bp(GO:macroautophagy) increases a(GO:autophagosome) + + + + + + + pubmed:22908190 + + bp(GO:macroautophagy) increases deg(p(HGNC:MAPT, frag("?"))) + + + + + + + pubmed:18930136 + + bp(GO:macroautophagy) increases bp(GO:"autophagosome-lysosome fusion") + + + + + + + pubmed:18930136 + + bp(GO:macroautophagy) increases deg(p(HGNC:SNCA)) + + + + + + + pubmed:30116051 + + bp(GO:macroautophagy) increases deg(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) + + + + + + + pubmed:29024336 + + bp(GO:macroautophagy) increases deg(p(MGI:Mapt)) + + + + + + + pubmed:29024336 + + bp(GO:macroautophagy) decreases deg(p(MGI:Mapt)) + + + + + + + pubmed:29024336 + + bp(GO:macroautophagy) increases deg(p(MGI:Mapt, var("p.Ala152Thr"))) + + + + + + + pubmed:29024336 + + bp(GO:macroautophagy) decreases deg(p(MGI:Mapt, var("p.Pro301Leu"))) + + + + + + + pubmed:29024336 + + bp(GO:macroautophagy) causesNoChange deg(p(MGI:Mapt, var("p.Pro301Leu"))) + + + + + + + pubmed:29024336 + + bp(GO:macroautophagy) increases deg(a(MESH:Proteins)) + + + + + + + pubmed:26751493 + + bp(GO:macroautophagy) decreases p(HGNC:MAPT) + + + + + + + pubmed:27181519 + + bp(GO:macroautophagy) isA bp(GO:"selective autophagy") + + + + + + + pubmed:27181519 + + bp(GO:macroautophagy) increases bp(GO:"ribonucleoprotein complex disassembly") + + + + + + + pubmed:27181519 + + bp(GO:macroautophagy) increases deg(complex(GO:"cytoplasmic stress granule")) + + + + + + + pubmed:26968346 + + p(HGNC:MEF2D) increases bp(GO:"neuron cellular homeostasis") + + + + + + + pubmed:26968346 + + p(MESH:Glucosylceramidase, var("?")) association path(DOID:"Gaucher's disease") + + + + + + + + + pubmed:26968346 + + p(MESH:Glucosylceramidase) decreases p(CONSO:"alpha-synuclein aggregates") + + + + + + + pubmed:26968346 + + p(MESH:Glucosylceramidase) decreases a(MESH:"Toxic Actions") + + + + + + + pubmed:26968346 + + act(p(MESH:Glucosylceramidase)) decreases act(p(HGNC:SNCA, var("?"))) + + + + + + + pubmed:26968346 + + act(p(MESH:Glucosylceramidase)) positiveCorrelation bp(GO:behavior) + + + + + + + pubmed:26968346 + + path(DOID:"Gaucher's disease") association p(MESH:Glucosylceramidase, var("?")) + + + + + + + pubmed:27299292 + + path(DOID:"Gaucher's disease") positiveCorrelation p(HGNC:GBA, var("p.Leu444Pro")) + + + + + + + pubmed:26968346 + + bp(GO:"regulation of glucosylceramidase activity") negativeCorrelation p(HGNC:SNCA) + + + + + + + pubmed:26968346 + + composite(p(HGNC:SNCA), p(HGNC:TFEB), loc(GO:"Lewy body")) increases p(HGNC:TFEB, loc(GO:cytoplasm)) + + + + + + + pubmed:26968346 + + composite(p(HGNC:SNCA), p(HGNC:TFEB), loc(GO:"Lewy body")) decreases act(p(HGNC:TFEB)) + + + + + + + pubmed:26968346 + + a(CHEBI:trehalose) increases act(p(HGNC:TFEB)) + + + + + + + pubmed:26968346 + + a(CHEBI:trehalose) increases tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) + + + + + + + pubmed:26968346 + + a(CHEBI:trehalose) decreases bp(GO:"cell death") + + + + + + + pubmed:26968346 + + a(CHEBI:trehalose) decreases p(CONSO:PrPSc) + + + + + + + pubmed:26968346 + + a(PUBCHEM:90479739) increases act(p(HGNC:TFEB)) + + + + + + + pubmed:27299292 + + a(PUBCHEM:90479739) increases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) + + + + + + + pubmed:27299292 + + a(PUBCHEM:90479739) increases act(p(HGNC:TFEB)) + + + + + + + pubmed:26968346 + + a(PUBCHEM:90479739) increases deg(p(CONSO:"alpha-synuclein aggregates")) + + + + + + + pubmed:27299292 + + a(PUBCHEM:90479739) decreases path(DOID:"Niemann-Pick disease type C1") + + + + + + + pubmed:27299292 + + a(PUBCHEM:90479739) decreases path(DOID:"Niemann-Pick disease type C2") + + + + + + + pubmed:26968346 + + a(PUBCHEM:277318041) increases act(p(HGNC:PINK1), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:26968346 + + p(HGNC:PRKN, var("p.Gln311?")) increases path(CONSO:"mitochondrial dysfunction") + + + + + + + pubmed:26968346 + + composite(p(HGNC:PPARGC1A), p(HGNC:TFEB)) increases bp(GO:mitophagy) + + + + + + + pubmed:26968346 + + composite(p(HGNC:PPARGC1A), p(HGNC:TFEB)) increases a(MESH:Mitochondria) + + + + + + + pubmed:26968346 + + p(HGNC:ZNF746) decreases composite(p(HGNC:PPARGC1A), p(HGNC:TFEB)) + + + + + + + pubmed:26968346 + + bp(GO:"proton-transporting V-type ATPase complex assembly") negativeCorrelation p(HGNC:PSEN1, var("?")) + + + + + + + pubmed:30108137 + + bp(GO:"lysosomal lumen acidification") positiveCorrelation p(HGNC:TFEB) + + + + + + + pubmed:26968346 + + bp(GO:"endomembrane system organization") positiveCorrelation p(HGNC:PSEN1) + + + + + + + pubmed:26968346 + + bp(GO:"endomembrane system organization") positiveCorrelation p(HGNC:PSEN2) + + + + + + + pubmed:26968346 + + p(HGNC:PTEN) decreases p(HGNC:AKT1) + + + + + + + pubmed:26968346 + + p(HGNC:PTEN) decreases p(HGNC:MTOR) + + + + + + + pubmed:27299292 + + act(p(HGNC:PTEN)) increases deg(p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) + + + + + + + pubmed:27299292 + + act(p(HGNC:PTEN)) increases deg(p(HGNC:MAPT, pmod(CONSO:misfolded))) + + + + + + + pubmed:27299292 + + act(p(HGNC:PTEN)) increases bp(GO:autophagy) + + + + + + + pubmed:27299292 + + act(p(HGNC:PTEN)) increases bp(GO:"protein catabolic process") + + + + + + + pubmed:29758300 + + p(HGNC:PTEN) increases bp(GO:macroautophagy) + + + + + + + + + pubmed:26968346 + + act(p(MESH:Lysosomes)) increases deg(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:26195256 + + act(p(MESH:Lysosomes)) increases deg(p(HGNC:MAPT)) + + + + + + + pubmed:26968346 + + m(MIRBASE:hsa-mir-128-1) decreases p(HGNC:TFEB) + + + + + + + pubmed:26968346 + + m(MIRBASE:hsa-mir-128-1) decreases p(HGNC:TFEB, loc(GO:nucleus)) + + + + + + + pubmed:27299292 + + m(MIRBASE:hsa-mir-128-1) decreases p(HGNC:TFEB) + + + + + + + pubmed:27299292 + + m(MIRBASE:hsa-mir-128-1) decreases p(HGNC:TFEB) + + + + + + + pubmed:27299292 + + m(MIRBASE:hsa-mir-128-1) decreases p(HGNC:TFEB) + + + + + + + pubmed:26968346 + + m(MIRBASE:hsa-mir-128-1) decreases r(HGNC:TFEB) + + + + + + + + + pubmed:27299292 + + act(m(MIRBASE:hsa-mir-128-1), ma(GO:"mRNA 3'-UTR binding")) increases complex(m(MIRBASE:hsa-mir-128-1), r(HGNC:TFEB)) + + + + + + + pubmed:27299292 + + m(MIRBASE:hsa-mir-128-1) decreases deg(a(CHEBI:"amyloid-beta polypeptide 42")) + + + + + + + pubmed:27299292 + + m(MIRBASE:hsa-mir-128-1) positiveCorrelation path(DOID:"Parkinson's disease") + + + + + + + pubmed:26968346 + + m(MIRBASE:hsa-mir-128-2) decreases p(HGNC:TFEB) + + + + + + + pubmed:26968346 + + m(MIRBASE:hsa-mir-128-2) decreases p(HGNC:TFEB, loc(GO:nucleus)) + + + + + + + pubmed:27299292 + + m(MIRBASE:hsa-mir-128-2) decreases p(HGNC:TFEB) + + + + + + + pubmed:26968346 + + m(MIRBASE:hsa-mir-128-2) decreases r(HGNC:TFEB) + + + + + + + + + pubmed:27299292 + + act(m(MIRBASE:hsa-mir-128-2), ma(GO:"mRNA 3'-UTR binding")) increases complex(m(MIRBASE:hsa-mir-128-2), r(HGNC:TFEB)) + + + + + + + pubmed:26968346 + + path(MESH:"Late Onset Disorders") increases m(MIRBASE:hsa-mir-128-1) + + + + + + + pubmed:26968346 + + path(MESH:"Late Onset Disorders") increases m(MIRBASE:hsa-mir-128-2) + + + + + + + pubmed:26968346 + + path(MESH:"Late Onset Disorders") decreases deg(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:26968346 + + path(MESH:"Late Onset Disorders") decreases p(MESH:Enzymes) + + + + + + + pubmed:26968346 + + p(HGNC:PSEN1, var("p.Ala246Glu")) increases bp(GO:"lysosomal lumen pH elevation") + + + + + + + pubmed:26968346 + + p(HGNC:PSEN1, var("p.Ala246Glu")) decreases act(p(HGNC:CTSD)) + + + + + + + pubmed:29758300 + + p(HGNC:PSEN1, var("p.Ala246Glu")) decreases bp(GO:autophagy) + + + + + + + pubmed:29758300 + + p(HGNC:PSEN1, var("p.Ala246Glu")) decreases bp(GO:mitophagy) + + + + + + + pubmed:29758300 + + p(HGNC:PSEN1, var("p.Ala246Glu")) decreases act(a(GO:lysosome)) + + + + + + + pubmed:26968346 + + bp(GO:"lysosomal lumen pH elevation") increases p(HGNC:TFEB) + + + + + + + pubmed:22692785 + + p(CONSO:PrPSc) negativeCorrelation p(HGNC:MARK4) + + + + + + + pubmed:26968346 + + a(CHEBI:quinacrine) decreases path(DOID:malaria) + + + + + + + pubmed:26968346 + + a(CHEBI:quinacrine) increases bp(GO:"autophagosome-lysosome fusion") + + + + + + + pubmed:26968346 + + a(CHEBI:quinacrine) decreases path(DOID:"prion disease") + + + + + + + pubmed:30108137 + + path(DOID:"lysosomal storage disease") association p(HGNC:TFEB, loc(GO:nucleus)) + + + + + + + pubmed:27299292 + + path(DOID:"lysosomal storage disease") increases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) + + + + + + + pubmed:27299292 + + path(DOID:"lysosomal storage disease") increases p(HGNC:TFEB, loc(GO:nucleus)) + + + + + + + pubmed:30108137 + + a(CONSO:"Braak_Stage VI") positiveCorrelation r(HGNC:TFEB) + + + + + + + + + + + pubmed:26702100 + + p(HGNC:LAMP1) association a(GO:lysosome) + + + + + + + pubmed:26702100 + + p(HGNC:LAMP1) association a(GO:lysosome) + + + + + + + pubmed:30108137 + + composite(a(MESH:Astrocytes), p(HGNC:TFEB)) increases p(CONSO:"Tau fibrils", loc(MESH:Astrocytes)) + + + + + + + pubmed:30108137 + + composite(a(MESH:Astrocytes), p(HGNC:TFEB)) increases composite(a(PUBCHEM:102513886), p(MESH:"Serum Albumin, Bovine")) + + + + + + + pubmed:30108137 + + composite(a(CHEBI:"torin 1"), a(MESH:Astrocytes), p(HGNC:TFEB)) increases p(CONSO:"Tau fibrils", loc(MESH:Astrocytes)) + + + + + + + pubmed:30108137 + + composite(a(PUBCHEM:102513886), p(MESH:"Serum Albumin, Bovine")) increases deg(a(PUBCHEM:102513886)) + + + + + + + pubmed:30108137 + + composite(a(PUBCHEM:102513886), p(MESH:"Serum Albumin, Bovine")) increases deg(p(MESH:"Serum Albumin, Bovine")) + + + + + + + + + + + pubmed:30108137 + + a(CHEBI:heparin) decreases p(CONSO:"Tau fibrils", loc(MESH:Lysosomes)) + + + + + + + pubmed:29590627 + + a(CHEBI:heparin) causesNoChange tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + + + + + + + pubmed:29590627 + + a(CHEBI:heparin) causesNoChange tloc(a(CONSO:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + + + + + + + pubmed:25887395 + + a(CHEBI:heparin) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:29988016 + + a(CHEBI:heparin) negativeCorrelation a(CONSO:"Tau aggregates") + + + + + + + pubmed:30108137 + + a(CHEBI:heparin) decreases tloc(a(CONSO:"Tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:25887395 + + a(CHEBI:heparin) decreases complex(a(CONSO:"Tau fibrils"), p(HGNCGENEFAMILY:Syndecans)) + + + + + + + pubmed:29988016 + + a(CHEBI:heparin) increases act(p(HGNC:MAPT, var("?"))) + + + + + + + + + pubmed:29686391 + + a(CHEBI:heparin) negativeCorrelation tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:29686391 + + a(CHEBI:heparin) decreases tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:26751493 + + a(CHEBI:heparin) association p(CONSO:"Tau aggregates") + + + + + + + pubmed:27601475 + + a(CHEBI:heparin) increases p(CONSO:"Tau aggregates") + + + + + + + + + pubmed:26751493 + + a(CHEBI:heparin) partOf complex(a(CHEBI:heparin), p(CONSO:"Tau aggregates")) + + + + + + + pubmed:30108137 + + bp(GO:macropinocytosis) increases tloc(p(CONSO:"Tau fibrils"), fromLoc(GO:cytoplasm), toLoc(MESH:Lysosomes)) + + + + + + + pubmed:29590627 + + bp(GO:macropinocytosis) negativeCorrelation a(CHEBI:"cytochalasin D") + + + + + + + pubmed:29590627 + + bp(GO:macropinocytosis) positiveCorrelation bp(GO:"actin filament polymerization") + + + + + + + pubmed:30108137 + + bp(GO:macropinocytosis) increases act(a(MESH:Astrocytes)) + + + + + + + pubmed:30108137 + + bp(GO:macropinocytosis) increases tloc(a(CONSO:"Tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:26751493 + + bp(GO:macropinocytosis) positiveCorrelation complex(a(CHEBI:heparin), p(CONSO:"Tau aggregates")) + + + + + + + pubmed:26751493 + + bp(GO:macropinocytosis) association complex(a(CHEBI:heparin), p(CONSO:"Tau aggregates")) + + + + + + + pubmed:26751493 + + bp(GO:macropinocytosis) isA tloc(a(CONSO:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) + + + + + + + pubmed:30108137 + + complex(MESH:Dependovirus) increases p(HGNC:TFEB, loc(MESH:Astrocytes)) + + + + + + + pubmed:30108137 + + complex(MESH:Dependovirus) increases act(p(HGNC:TFEB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) + + + + + + + pubmed:30108137 + + complex(MESH:Dependovirus) increases p(HGNC:TFEB, loc(MESH:Astrocytes)) + + + + + + + pubmed:30108137 + + complex(MESH:Dependovirus) increases r(HGNC:TFEB) + + + + + + + pubmed:30108137 + + path(CONSO:"Pathological Tau Spreading") association tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:30108137 + + bp(GO:"ATP export") association bp(GO:"neuron-neuron synaptic transmission") + + + + + + + pubmed:30108137 + + bp(GO:"reactive gliosis") increases p(HGNC:AIF1) + + + + + + + pubmed:30108137 + + bp(GO:"reactive gliosis") increases p(HGNC:GFAP) + + + + + + + pubmed:27299292 + + p(MESH:"AMP-Activated Protein Kinases") association p(HGNC:PPARGC1A) + + + + + + + pubmed:27299292 + + complex(MESH:"Mechanistic Target of Rapamycin Complex 1") association p(HGNC:PPARGC1A) + + + + + + + pubmed:27299292 + + complex(MESH:"Mechanistic Target of Rapamycin Complex 2") association p(HGNC:PPARGC1A) + + + + + + + pubmed:27299292 + + bp(GO:"cellular response to starvation") increases act(p(HGNC:TFEB)) + + + + + + + pubmed:27299292 + + bp(GO:"cellular response to starvation") increases act(p(HGNC:TFEB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) + + + + + + + pubmed:27299292 + + bp(GO:"cellular response to starvation") decreases p(HGNC:TFEB, loc(GO:cytoplasm)) + + + + + + + pubmed:27299292 + + bp(GO:"cellular response to starvation") increases act(p(HGNC:TFEB)) + + + + + + + pubmed:27299292 + + bp(GO:"cellular response to starvation") increases act(p(HGNC:TFEB)) + + + + + + + pubmed:27299292 + + bp(GO:"cellular response to starvation") increases p(HGNC:CREBBP) + + + + + + + pubmed:27299292 + + bp(GO:"cellular response to starvation") decreases act(p(HGNC:MAPK1), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:27299292 + + bp(GO:"cellular response to starvation") decreases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation", Ser, 142)) + + + + + + + pubmed:27299292 + + bp(GO:"cellular response to starvation") increases act(a(MESH:Lysosomes)) + + + + + + + pubmed:27299292 + + bp(GO:"cellular response to starvation") decreases p(HGNCGENEFAMILY:"MTOR complex 1") + + + + + + + pubmed:27299292 + + bp(GO:"cellular response to starvation") increases tloc(p(HGNC:MITF), fromLoc(MESH:Lysosomes), toLoc(GO:nucleus)) + + + + + + + pubmed:27299292 + + bp(GO:"cellular response to starvation") increases tloc(p(HGNC:TFE3), fromLoc(MESH:Lysosomes), toLoc(GO:nucleus)) + + + + + + + pubmed:27299292 + + composite(p(HGNC:MITF), p(HGNC:TFE3), p(HGNC:TFEB)) regulates bp(GO:mitophagy) + + + + + + + pubmed:27299292 + + composite(p(HGNC:MITF), p(HGNC:TFE3), p(HGNC:TFEB)) association p(HGNC:PINK1) + + + + + + + pubmed:27299292 + + composite(p(HGNC:MITF), p(HGNC:TFE3), p(HGNC:TFEB)) association p(HGNC:PRKN) + + + + + + + pubmed:27299292 + + composite(p(HGNC:MITF), p(HGNC:TFE3), p(HGNC:TFEB)) association p(HGNC:ATG9A) + + + + + + + pubmed:27299292 + + composite(p(HGNC:MITF), p(HGNC:TFE3), p(HGNC:TFEB)) association p(HGNC:ATG5) + + + + + + + + + + + + + pubmed:27299292 + + act(p(HGNC:MITF)) increases a(GO:endolysosome) + + + + + + + + + + + + + + + pubmed:27299292 + + act(p(HGNC:TFE3), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) regulates a(MESH:Lysosomes) + + + + + + + pubmed:27299292 + + act(p(HGNC:TFE3), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) regulates bp(GO:autophagy) + + + + + + + pubmed:27299292 + + act(p(HGNC:TFE3), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases p(HGNC:FLCN) + + + + + + + pubmed:27299292 + + act(p(HGNC:TFE3), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases p(HGNC:FNIP1) + + + + + + + pubmed:27299292 + + act(p(HGNC:TFE3), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases p(HGNC:FNIP2) + + + + + + + pubmed:27299292 + + act(p(HGNC:TFE3), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) decreases bp(GO:"cellular response to starvation") + + + + + + + pubmed:27299292 + + p(HGNC:TFE3) regulates bp(GO:"cellular response to stress") + + + + + + + pubmed:27299292 + + p(HGNC:TFE3) regulates p(HGNC:PPARGC1A) + + + + + + + pubmed:27299292 + + p(HGNC:TFE3) association p(HGNC:ATF4) + + + + + + + + + pubmed:27299292 + + p(HGNC:TFE3) increases bp(GO:"calcium ion regulated lysosome exocytosis") + + + + + + + pubmed:27299292 + + act(p(HGNC:TFE3)) directlyIncreases bp(GO:"catabolic process") + + + + + + + pubmed:27299292 + + p(HGNC:ATG9A) association composite(p(HGNC:MITF), p(HGNC:TFE3), p(HGNC:TFEB)) + + + + + + + + + pubmed:27299292 + + composite(p(HGNC:ATG5), p(HGNC:ATG9A), p(HGNC:MITF), p(HGNC:PINK1), p(HGNC:PRKN), p(HGNC:TFE3), p(HGNC:TFEB)) positiveCorrelation bp(GO:mitophagy) + + + + + + + pubmed:27299292 + + p(HGNC:ZKSCAN3) decreases bp(GO:autophagy) + + + + + + + pubmed:27299292 + + p(HGNC:ZKSCAN3) decreases act(p(HGNC:TFEB)) + + + + + + + pubmed:30116051 + + p(HGNC:ZKSCAN3) decreases bp(GO:macroautophagy) + + + + + + + pubmed:27299292 + + bp(GO:"lipid catabolic process") positiveCorrelation p(HGNC:TFEB) + + + + + + + pubmed:27299292 + + bp(MESH:"Diet, High-Fat") regulates bp(GO:"lipid catabolic process") + + + + + + + pubmed:27299292 + + p(HGNC:GBA, var("p.Leu444Pro")) positiveCorrelation path(DOID:"Gaucher's disease") + + + + + + + pubmed:27299292 + + p(HGNC:GBA, var("p.Leu444Pro")) negativeCorrelation bp(GO:"protein transport") + + + + + + + pubmed:27299292 + + p(HGNC:GBA, var("p.Leu444Pro")) negativeCorrelation bp(GO:"protein maturation") + + + + + + + + + + + pubmed:27299292 + + bp(GO:"protein maturation") negativeCorrelation p(HGNC:GBA, var("p.Leu444Pro")) + + + + + + + pubmed:27299292 + + bp(GO:"protein maturation") positiveCorrelation p(HGNC:TFEB) + + + + + + + pubmed:27299292 + + complex(m(MIRBASE:hsa-mir-128-1), r(HGNC:TFEB)) decreases p(HGNC:TFEB) + + + + + + + pubmed:27299292 + + complex(m(MIRBASE:hsa-mir-128-2), r(HGNC:TFEB)) decreases p(HGNC:TFEB) + + + + + + + pubmed:27299292 + + a(CHEBI:sucrose) increases bp(MESH:"Stress, Physiological") + + + + + + + pubmed:27299292 + + a(CHEBI:"arsenic(3+)") increases bp(MESH:"Stress, Physiological") + + + + + + + pubmed:27299292 + + a(CHEBI:"arsenic(3+)") increases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) + + + + + + + pubmed:27299292 + + bp(GO:"response to transition metal nanoparticle") increases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) + + + + + + + pubmed:27299292 + + bp(GO:"cellular response to ethanol") increases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) + + + + + + + pubmed:27299292 + + bp(GO:"response to doxorubicin") increases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) + + + + + + + pubmed:27299292 + + bp(GO:"response to doxorubicin") positiveCorrelation bp(GO:"cellular senescence") + + + + + + + pubmed:27299292 + + bp(GO:"cellular senescence") positiveCorrelation bp(GO:"response to doxorubicin") + + + + + + + pubmed:30126037 + + bp(GO:"cellular senescence") association bp(GO:"cell cycle") + + + + + + + pubmed:30126037 + + bp(GO:"cellular senescence") increases bp(MESH:"Cell Survival") + + + + + + + pubmed:30126037 + + bp(GO:"cellular senescence") increases bp(MESH:"Cell Survival") + + + + + + + pubmed:30126037 + + bp(GO:"cellular senescence") association bp(MESH:"Cell Survival") + + + + + + + pubmed:30126037 + + bp(GO:"cellular senescence") increases bp(GO:"tissue remodeling") + + + + + + + pubmed:30126037 + + bp(GO:"cellular senescence") increases bp(GO:"tissue remodeling") + + + + + + + pubmed:30126037 + + bp(GO:"cellular senescence") decreases bp(GO:"metabolic process") + + + + + + + pubmed:30126037 + + bp(GO:"cellular senescence") decreases bp(GO:"metabolic process") + + + + + + + pubmed:30126037 + + bp(GO:"cellular senescence") association p(MGI:Cdkn2a) + + + + + + + pubmed:30126037 + + bp(GO:"cellular senescence") increases a(GO:"neurofibrillary tangle") + + + + + + + pubmed:30126037 + + bp(GO:"cellular senescence") association a(GO:"neurofibrillary tangle") + + + + + + + pubmed:30126037 + + bp(GO:"cellular senescence") increases bp(GO:"neuron death") + + + + + + + pubmed:30126037 + + bp(GO:"cellular senescence") increases path(MESH:"Hypertrophy, Right Ventricular") + + + + + + + pubmed:30126037 + + bp(GO:"cellular senescence") increases path(MESH:"Hypertrophy, Left Ventricular") + + + + + + + pubmed:30126037 + + bp(GO:"cellular senescence") increases bp(HP:Neurodegeneration) + + + + + + + pubmed:30126037 + + bp(GO:"cellular senescence") association path(MESH:Tauopathies) + + + + + + + pubmed:30126037 + + bp(GO:"cellular senescence") increases bp(GO:"cell cycle arrest") + + + + + + + pubmed:30126037 + + bp(GO:"cellular senescence") decreases tloc(a(MESH:Immunotoxins), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:30126037 + + bp(GO:"cellular senescence") increases bp(MESH:"DNA Damage") + + + + + + + pubmed:30126037 + + bp(GO:"cellular senescence") association bp(MESH:"DNA Damage") + + + + + + + pubmed:30126037 + + bp(GO:"cellular senescence") increases p(MGI:Cdkn1a) + + + + + + + pubmed:30126037 + + bp(GO:"cellular senescence") increases p(HGNC:CDKN2A) + + + + + + + pubmed:30126037 + + bp(GO:"cellular senescence") association bp(GO:"inflammatory response") + + + + + + + pubmed:30126037 + + bp(GO:"cellular senescence") increases path(CONSO:CONSO00037) + + + + + + + pubmed:29221819 + + bp(GO:"cellular senescence") positiveCorrelation p(MGI:Dyrk1a) + + + + + + + pubmed:27299292 + + complex(p(HGNC:PPARGC1A), r(HGNC:TFEB)) regulates p(HGNC:TFEB) + + + + + + + pubmed:27299292 + + complex(p(HGNC:PPARGC1A), r(HGNC:TFEB)) regulates act(p(HGNC:TFEB)) + + + + + + + pubmed:27299292 + + complex(p(HGNC:PPARGC1A), r(HGNC:TFEB)) regulates bp(GO:mitophagy) + + + + + + + pubmed:27299292 + + complex(p(HGNC:PPARGC1A), p(HGNC:RXRA), r(HGNC:TFEB)) regulates act(p(HGNC:TFEB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) + + + + + + + + + pubmed:27299292 + + a(CHEBI:gemfibrozil) increases act(p(HGNC:PPARGC1A)) + + + + + + + pubmed:27299292 + + bp(GO:"cellular response to nutrient") increases p(HGNC:NR1H4) + + + + + + + pubmed:27299292 + + bp(GO:"cellular response to nutrient") increases complex(p(HGNC:MITF), p(HGNC:YWHAQ)) + + + + + + + pubmed:27299292 + + bp(GO:"cellular response to nutrient") increases complex(p(HGNC:TFE3), p(HGNC:YWHAQ)) + + + + + + + pubmed:27299292 + + bp(GO:"cellular response to nutrient") increases act(p(HGNC:TFE3), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) + + + + + + + pubmed:27299292 + + p(HGNC:NR1H4) increases p(HGNC:TFEB) + + + + + + + pubmed:27299292 + + p(HGNC:NR1H4) regulates act(p(HGNC:TFEB), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) + + + + + + + pubmed:27299292 + + bp(GO:"biosynthetic process") association act(p(HGNCGENEFAMILY:"MTOR complex 1"), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:27299292 + + bp(GO:"catabolic process") association act(p(HGNCGENEFAMILY:"MTOR complex 1"), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:27299292 + + p(HGNC:TSC2) positiveCorrelation p(HGNCGENEFAMILY:"MTOR complex 1") + + + + + + + pubmed:27299292 + + p(HGNC:TSC2) increases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:27299292 + + p(HGNC:TSC2) decreases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) + + + + + + + + + pubmed:27299292 + + composite(a(CHEBI:sirolimus), p(HGNC:TFEB, frag("?_*"))) increases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) + + + + + + + + + pubmed:27299292 + + composite(p(HGNC:TFEB), p(HGNC:YWHAQ)) increases p(HGNC:TFEB, loc(GO:cytosol)) + + + + + + + pubmed:27299292 + + composite(p(HGNC:TFEB), p(HGNC:YWHAQ)) decreases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) + + + + + + + pubmed:27299292 + + composite(p(HGNC:TFEB), p(HGNC:YWHAQ)) decreases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) + + + + + + + + + + + + + pubmed:27299292 + + p(HGNC:TFEB, frag("241_252")) isA a(MESH:"Nuclear Localization Signals") + + + + + + + + + pubmed:27299292 + + bp(GO:"response to nutrient levels") causesNoChange act(complex(GO:"Ragulator complex")) + + + + + + + pubmed:27299292 + + p(HGNC:TFEB, frag("1_30")) increases p(HGNC:TFEB, loc(MESH:Lysosomes)) + + + + + + + pubmed:27299292 + + bp(GO:"amino acid activation") increases composite(complex(GO:"Ragulator complex"), p(HGNC:TFEB)) + + + + + + + pubmed:27299292 + + composite(complex(GO:"Ragulator complex"), p(HGNC:TFEB)) increases p(HGNC:TFEB, loc(MESH:Lysosomes)) + + + + + + + pubmed:27299292 + + a(PUBCHEM:17755052) decreases act(p(HGNC:PIK3CA)) + + + + + + + pubmed:27299292 + + a(PUBCHEM:17755052) increases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) + + + + + + + pubmed:27299292 + + p(HGNC:TNFSF11) increases act(p(HGNC:PRKCB)) + + + + + + + pubmed:27299292 + + p(HGNC:TNFSF11) regulates bp(GO:"osteoclast differentiation") + + + + + + + pubmed:27299292 + + act(p(HGNC:PRKCB)) increases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation", Ser)) + + + + + + + pubmed:27299292 + + p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation", Ser)) increases act(p(HGNC:TFEB)) + + + + + + + pubmed:27299292 + + bp(GO:"response to chloroquine") increases bp(MESH:"Stress, Physiological") + + + + + + + pubmed:27299292 + + bp(GO:"response to chloroquine") increases tloc(p(HGNC:MITF), fromLoc(MESH:Lysosomes), toLoc(GO:nucleus)) + + + + + + + pubmed:27299292 + + bp(GO:"response to chloroquine") increases tloc(p(HGNC:TFE3), fromLoc(MESH:Lysosomes), toLoc(GO:nucleus)) + + + + + + + pubmed:27299292 + + p(HGNC:FLCN) positiveCorrelation act(p(HGNCGENEFAMILY:"MTOR complex 1")) + + + + + + + pubmed:27299292 + + p(HGNC:FLCN) association tloc(p(HGNCGENEFAMILY:"MTOR complex 1"), fromLoc(GO:cytoplasm), toLoc(GO:"lysosomal membrane")) + + + + + + + pubmed:27299292 + + p(HGNC:FLCN) association act(p(HGNCGENEFAMILY:"MTOR complex 1")) + + + + + + + pubmed:27299292 + + p(HGNC:FLCN) negativeCorrelation path(DOID:"Birt-Hogg-Dube syndrome") + + + + + + + + + + + + + + + pubmed:27299292 + + complex(p(HGNC:SNCA), p(HGNC:TFEB)) increases p(HGNC:TFEB, loc(GO:cytoplasm)) + + + + + + + pubmed:27299292 + + complex(p(HGNC:SNCA), p(HGNC:TFEB)) decreases tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) + + + + + + + pubmed:27299292 + + p(HGNC:AR, pmod(CONSO:"CAG repeats")) positiveCorrelation bp(GO:autophagy) + + + + + + + pubmed:27299292 + + p(HGNC:AR, pmod(CONSO:"CAG repeats")) negativeCorrelation bp(GO:autophagy) + + + + + + + pubmed:27299292 + + p(HGNC:AR, pmod(CONSO:"CAG repeats")) negativeCorrelation bp(GO:autophagy) + + + + + + + pubmed:27299292 + + p(HGNC:AR, pmod(CONSO:"CAG repeats")) increases p(HGNC:NFYA) + + + + + + + pubmed:27299292 + + p(HGNC:AR, pmod(CONSO:"CAG repeats")) decreases act(a(MESH:Lysosomes)) + + + + + + + pubmed:27299292 + + p(HGNC:AR, pmod(CONSO:"CAG repeats")) decreases act(p(HGNC:TFEB)) + + + + + + + + + pubmed:27299292 + + p(HGNC:AR) increases r(HGNC:TFEB) + + + + + + + + + + + + + pubmed:30640040 + + p(HGNC:AR) association a(PUBCHEM:5833) + + + + + + + pubmed:27299292 + + path(DOID:"spinal muscular atrophy") negativeCorrelation act(p(HGNCGENEFAMILY:"MTOR complex 1")) + + + + + + + pubmed:27299292 + + path(DOID:"spinal muscular atrophy") negativeCorrelation bp(GO:autophagy) + + + + + + + pubmed:27299292 + + path(DOID:"spinal muscular atrophy") positiveCorrelation path(CONSO:"mitochondrial dysfunction") + + + + + + + pubmed:27299292 + + p(HGNC:NFYA) decreases p(HGNC:TFEB) + + + + + + + + + pubmed:27299292 + + p(HGNC:NFYA) increases bp(GO:"nuclear protein quality control by the ubiquitin-proteasome system") + + + + + + + pubmed:27299292 + + composite(p(HGNC:NFYA), p(HGNC:TFEB)) decreases act(a(MESH:Lysosomes)) + + + + + + + pubmed:27299292 + + composite(p(HGNC:NFYA), p(HGNC:TFEB)) decreases bp(GO:autophagy) + + + + + + + pubmed:27299292 + + composite(p(HGNC:NFYA), p(HGNC:TFEB)) increases p(HGNC:AR, pmod(CONSO:"CAG repeats")) + + + + + + + pubmed:27299292 + + p(HGNC:SESN2) association p(HGNCGENEFAMILY:"MTOR complex 1") + + + + + + + pubmed:30116051 + + p(HGNC:SESN2) increases act(p(FPLX:AMPK)) + + + + + + + pubmed:30116051 + + p(HGNC:SESN2) increases bp(GO:macroautophagy) + + + + + + + pubmed:30116051 + + p(HGNC:SESN2) increases bp(GO:macroautophagy) + + + + + + + pubmed:30116051 + + p(HGNC:SESN2) increases act(p(FPLX:mTORC1)) + + + + + + + pubmed:27299292 + + path(CONSO:"protein aggregation") negativeCorrelation act(a(MESH:Lysosomes)) + + + + + + + pubmed:27299292 + + path(CONSO:"protein aggregation") decreases p(HGNC:TFEB) + + + + + + + pubmed:27299292 + + path(CONSO:"protein aggregation") decreases act(p(HGNC:TFEB)) + + + + + + + pubmed:27299292 + + path(DOID:"Birt-Hogg-Dube syndrome") negativeCorrelation p(HGNC:FLCN) + + + + + + + pubmed:27299292 + + path(DOID:"Birt-Hogg-Dube syndrome") positiveCorrelation path(DOID:"hair follicle neoplasm") + + + + + + + pubmed:27299292 + + path(DOID:"Birt-Hogg-Dube syndrome") increases path(MESH:Cysts) + + + + + + + pubmed:27299292 + + path(DOID:"Birt-Hogg-Dube syndrome") positiveCorrelation path(DOID:"renal carcinoma") + + + + + + + pubmed:27299292 + + path(DOID:"hair follicle neoplasm") positiveCorrelation path(DOID:"Birt-Hogg-Dube syndrome") + + + + + + + pubmed:27299292 + + composite(p(HGNC:FLCN), p(HGNCGENEFAMILY:"MTOR complex 1")) increases p(HGNC:TFEB) + + + + + + + pubmed:27299292 + + composite(p(HGNC:FLCN), p(HGNCGENEFAMILY:"MTOR complex 1")) increases act(p(HGNC:TFEB)) + + + + + + + pubmed:27299292 + + composite(p(HGNC:FLCN), p(HGNCGENEFAMILY:"MTOR complex 1")) increases a(MESH:Lysosomes) + + + + + + + pubmed:27299292 + + path(DOID:"pancreatic ductal adenocarcinoma") increases p(HGNC:IPO8) + + + + + + + + + + + + + pubmed:27299292 + + complex(p(HGNC:IPO8), p(HGNC:TFE3)) negativeCorrelation p(HGNCGENEFAMILY:"MTOR complex 1") + + + + + + + pubmed:27299292 + + complex(p(HGNC:IPO8), p(HGNC:TFE3)) increases tloc(p(HGNC:TFE3), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) + + + + + + + pubmed:27299292 + + complex(p(HGNC:IPO8), p(HGNC:TFEB)) negativeCorrelation p(HGNCGENEFAMILY:"MTOR complex 1") + + + + + + + pubmed:27299292 + + complex(p(HGNC:IPO8), p(HGNC:TFEB)) increases tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) + + + + + + + pubmed:27299292 + + complex(p(HGNC:IPO8), p(HGNC:MITF)) negativeCorrelation p(HGNCGENEFAMILY:"MTOR complex 1") + + + + + + + pubmed:27299292 + + complex(p(HGNC:IPO8), p(HGNC:MITF)) increases tloc(p(HGNC:MITF), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) + + + + + + + pubmed:27299292 + + complex(p(INTERPRO:"MiT/TFE transcription factors, C-terminal"), p(INTERPRO:"MiT/TFE transcription factors, N-terminal")) increases act(a(MESH:Lysosomes)) + + + + + + + pubmed:27299292 + + complex(p(INTERPRO:"MiT/TFE transcription factors, C-terminal"), p(INTERPRO:"MiT/TFE transcription factors, N-terminal")) increases bp(GO:autophagy) + + + + + + + + + + + pubmed:27299292 + + a(CHEBI:"angiotensin II") increases complex(GO:"Fused-Smurf ubiquitin ligase complex") + + + + + + + pubmed:27299292 + + complex(GO:"Fused-Smurf ubiquitin ligase complex") increases p(HGNC:TRIM63) + + + + + + + + + + + + + pubmed:27299292 + + p(HGNC:TRIM63) directlyIncreases act(p(HGNC:TFEB)) + + + + + + + pubmed:27299292 + + a(CHEBI:glycogen, loc(MESH:Muscles)) increases path(DOID:"glycogen storage disease II") + + + + + + + pubmed:27299292 + + a(CHEBI:paeoniflorin) increases tloc(p(HGNC:TFEB), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) + + + + + + + pubmed:27299292 + + a(CHEBI:paeoniflorin) increases act(p(HGNC:TFEB)) + + + + + + + pubmed:27299292 + + bp(GO:"nuclear protein quality control by the ubiquitin-proteasome system") increases deg(p(HGNC:AR, pmod(CONSO:"CAG repeats"))) + + + + + + + pubmed:27299292 + + bp(GO:"nuclear protein quality control by the ubiquitin-proteasome system") decreases path(DOID:"spinal muscular atrophy") + + + + + + + + + + + + + pubmed:27299292 + + p(HGNC:SERPINA1, pmod(CONSO:misfolded)) increases p(HGNC:SERPINA1, pmod(CONSO:"protein aggregates")) + + + + + + + pubmed:25437566 + + act(p(FPLX:HSPA)) association a(CHEBI:ATP) + + + + + + + pubmed:27491084 + + p(FPLX:HSPA) association bp(CONSO:Proteostasis) + + + + + + + pubmed:27491084 + + p(FPLX:HSPA) decreases p(CONSO:"huntingtin aggregates") + + + + + + + pubmed:27491084 + + p(FPLX:HSPA) decreases path(MESH:"Protein Aggregation, Pathological") + + + + + + + pubmed:24563850 + + p(FPLX:HSPA) decreases path(MESH:"Protein Aggregation, Pathological") + + + + + + + pubmed:27491084 + + p(FPLX:HSPA) increases bp(GO:"'de novo' protein folding") + + + + + + + pubmed:23746257 + + act(p(FPLX:HSPA)) association bp(GO:"'de novo' protein folding") + + + + + + + pubmed:23746257 + + act(p(FPLX:HSPA)) association bp(GO:"'de novo' protein folding") + + + + + + + pubmed:24563850 + + p(FPLX:HSPA) increases bp(GO:"'de novo' protein folding") + + + + + + + pubmed:27491084 + + p(FPLX:HSPA) decreases bp(CONSO:misfolding) + + + + + + + pubmed:27491084 + + p(FPLX:HSPA) association bp(CONSO:misfolding) + + + + + + + pubmed:24563850 + + p(FPLX:HSPA) decreases bp(CONSO:misfolding) + + + + + + + pubmed:27491084 + + p(FPLX:HSPA) decreases a(MESH:"Protein Aggregates") + + + + + + + pubmed:27491084 + + p(FPLX:HSPA) decreases a(MESH:"Protein Aggregates") + + + + + + + pubmed:27491084 + + p(FPLX:HSPA) decreases path(CONSO:proteotoxicity) + + + + + + + pubmed:27491084 + + p(FPLX:HSPA) decreases path(CONSO:proteotoxicity) + + + + + + + pubmed:27491084 + + p(FPLX:HSPA) decreases a(CONSO:"alpha-synuclein aggregates") + + + + + + + pubmed:23746257 + + p(FPLX:HSPA) decreases a(CONSO:"alpha-synuclein aggregates") + + + + + + + pubmed:14556719 + + p(FPLX:HSPA) increases complex(p(HGNC:ATXN3, frag("?")), p(HGNC:PRKN)) + + + + + + + pubmed:14556719 + + p(FPLX:HSPA) decreases a(CONSO:"protein aggregates") + + + + + + + pubmed:14556719 + + p(FPLX:HSPA) decreases bp(GO:"cell death") + + + + + + + pubmed:23746257 + + act(p(FPLX:HSPA)) association bp(GO:"protein refolding") + + + + + + + pubmed:23746257 + + act(p(FPLX:HSPA)) association bp(GO:"protein refolding") + + + + + + + + + pubmed:23746257 + + act(p(FPLX:HSPA)) association bp(GO:"intracellular protein transmembrane transport") + + + + + + + pubmed:23746257 + + act(p(FPLX:HSPA)) association bp(GO:"protein catabolic process") + + + + + + + + + + + pubmed:23746257 + + p(FPLX:HSPA) decreases a(CONSO:"huntingtin aggregates") + + + + + + + + + pubmed:25784053 + + p(FPLX:HSPA) isA a(MESH:"Molecular Chaperones") + + + + + + + pubmed:25784053 + + p(FPLX:HSPA) regulates bp(GO:"protein folding") + + + + + + + pubmed:24563850 + + p(FPLX:HSPA) increases bp(GO:"protein folding") + + + + + + + pubmed:25784053 + + p(FPLX:HSPA) regulates bp(MESH:Proteolysis) + + + + + + + + + pubmed:25784053 + + p(FPLX:HSPA) positiveCorrelation path(MESH:"Huntington Disease") + + + + + + + pubmed:29626319 + + p(FPLX:HSPA) increases deg(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:25437566 + + act(p(HGNC:HSPD1)) association a(CHEBI:ATP) + + + + + + + pubmed:27491084 + + p(HGNC:HSPD1) association bp(CONSO:Proteostasis) + + + + + + + pubmed:25784053 + + p(HGNC:HSPD1) increases bp(CONSO:Proteostasis) + + + + + + + pubmed:23746257 + + p(HGNC:HSPD1) decreases a(MESH:"Protein Aggregates") + + + + + + + + + + + pubmed:25784053 + + p(HGNC:HSPD1) isA a(MESH:"Molecular Chaperones") + + + + + + + pubmed:25784053 + + p(HGNC:HSPD1) association bp(MESH:"Energy Metabolism") + + + + + + + pubmed:25437566 + + act(p(HGNCGENEFAMILY:"AAA ATPases")) association a(CHEBI:ATP) + + + + + + + pubmed:27491084 + + p(HGNCGENEFAMILY:"AAA ATPases") association bp(CONSO:Proteostasis) + + + + + + + pubmed:27491084 + + p(HGNC:TPR) association bp(CONSO:Proteostasis) + + + + + + + pubmed:27491084 + + p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") association bp(CONSO:Proteostasis) + + + + + + + pubmed:27491084 + + p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") increases act(p(FPLX:HSPA), ma(GO:"ATPase activity")) + + + + + + + pubmed:23746257 + + p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") regulates act(p(FPLX:HSPA)) + + + + + + + + + pubmed:23746257 + + p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") decreases a(CONSO:"huntingtin aggregates") + + + + + + + pubmed:23746257 + + p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") decreases a(CONSO:"alpha-synuclein aggregates") + + + + + + + pubmed:25784053 + + p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins") isA a(MESH:"Molecular Chaperones") + + + + + + + pubmed:27491084 + + p(FPLX:HSPB) association bp(CONSO:Proteostasis) + + + + + + + pubmed:27491084 + + p(FPLX:HSPB) association bp(CONSO:misfolding) + + + + + + + pubmed:23746257 + + act(p(FPLX:HSPB)) decreases a(MESH:"Protein Aggregates") + + + + + + + pubmed:25784053 + + p(FPLX:HSPB) isA a(MESH:"Molecular Chaperones") + + + + + + + pubmed:30837838 + + p(HGNC:DNAJB2) increases complex(p(CONSO:"TDP-43 aggregates"), p(HGNCGENEFAMILY:"Heat shock 70kDa proteins")) + + + + + + + pubmed:25437566 + + p(FPLX:"CCT_complex") decreases a(CHEBI:"amyloid-beta polypeptide 42") + + + + + + + pubmed:25437566 + + p(FPLX:"CCT_complex") increases a(CONSO:"huntingtin aggregates") + + + + + + + pubmed:23746257 + + p(FPLX:"CCT_complex") decreases a(CONSO:"huntingtin aggregates") + + + + + + + + + + + pubmed:25784053 + + p(FPLX:"CCT_complex") association a(MESH:"Cellular Structures") + + + + + + + pubmed:25784053 + + p(FPLX:"CCT_complex") association bp(GO:"cell division") + + + + + + + pubmed:25784053 + + p(FPLX:"CCT_complex") association bp(GO:"intracellular transport") + + + + + + + pubmed:25784053 + + p(FPLX:"CCT_complex") decreases act(p(HGNC:HSF1)) + + + + + + + pubmed:25437566 + + p(HGNC:DNAJA1) decreases a(CHEBI:"amyloid-beta polypeptide 42") + + + + + + + pubmed:25437566 + + p(HGNC:DNAJA1) increases bp(GO:"protein folding") + + + + + + + pubmed:25437566 + + p(HGNC:DNAJA1) increases a(CONSO:"huntingtin aggregates") + + + + + + + pubmed:25437566 + + p(HGNC:CDC37) decreases a(CHEBI:"amyloid-beta polypeptide 42") + + + + + + + pubmed:23746257 + + p(HGNC:CDC37) decreases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) + + + + + + + pubmed:21882945 + + p(HGNC:CDC37) regulates act(p(FPLX:HSP90), ma(GO:"ATPase activity")) + + + + + + + pubmed:21367866 + + p(HGNC:CDC37) positiveCorrelation act(p(FPLX:HSP90)) + + + + + + + + + pubmed:25036637 + + p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(INTERPRO:"Heat shock protein Hsp90 family")) + + + + + + + + + pubmed:25036637 + + p(HGNC:CDC37) directlyIncreases complex(p(HGNC:AHSA1), p(HGNC:CDC37)) + + + + + + + + + pubmed:25036637 + + p(HGNC:CDC37) directlyIncreases complex(p(HGNC:AURKB), p(HGNC:CDC37)) + + + + + + + + + pubmed:25036637 + + p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:CDK11A)) + + + + + + + + + pubmed:25036637 + + p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:CDK1)) + + + + + + + + + pubmed:25036637 + + p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:IKBKG)) + + + + + + + + + pubmed:25036637 + + p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:CDK4)) + + + + + + + + + pubmed:25036637 + + p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:FER)) + + + + + + + + + pubmed:25036637 + + p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:IKBKB)) + + + + + + + + + pubmed:25036637 + + p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:CHUK)) + + + + + + + + + pubmed:25036637 + + p(HGNC:CDC37) directlyIncreases complex(p(HGNC:CDC37), p(HGNC:RAF1)) + + + + + + + + + pubmed:25036637 + + p(HGNC:CDC37) directlyIncreases complex(p(HGNC:ABL2), p(HGNC:CDC37)) + + + + + + + + + pubmed:25036637 + + p(HGNC:CDC37) directlyIncreases complex(p(HGNC:ARAF), p(HGNC:CDC37)) + + + + + + + pubmed:25036637 + + p(HGNC:CDC37) association p(HGNC:FKBP5) + + + + + + + + + pubmed:25036637 + + p(HGNC:CDC37) directlyIncreases complex(a(MESH:"Protein Kinases"), p(HGNC:CDC37)) + + + + + + + pubmed:21882945 + + p(HGNC:CDC37) increases complex(a(MESH:"Protein Kinases"), p(FPLX:HSP90)) + + + + + + + + + pubmed:21367866 + + p(HGNC:CDC37) isA complex(p(FPLX:HSP90), p(HGNC:CDC37)) + + + + + + + pubmed:29311797 + + p(HGNC:CDC37) increases p(HGNC:MAPT) + + + + + + + pubmed:21367866 + + p(HGNC:CDC37) decreases deg(p(HGNC:MAPT)) + + + + + + + pubmed:21367866 + + p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) + + + + + + + pubmed:21367866 + + p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) + + + + + + + pubmed:21367866 + + p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) + + + + + + + pubmed:21367866 + + p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) + + + + + + + pubmed:21367866 + + p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + + + + + + + pubmed:21367866 + + p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) + + + + + + + pubmed:21367866 + + p(HGNC:CDC37) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) + + + + + + + pubmed:21367866 + + p(HGNC:CDC37) negativeCorrelation act(p(HGNC:CDK5), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:21367866 + + p(HGNC:CDC37) negativeCorrelation act(p(HGNC:AKT1), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:21367866 + + p(HGNC:CDC37) causesNoChange p(HGNC:GSK3B) + + + + + + + pubmed:21367866 + + p(HGNC:CDC37) causesNoChange p(HGNC:MARK2) + + + + + + + pubmed:25437566 + + p(HGNC:STIP1) decreases a(CHEBI:"amyloid-beta polypeptide 42") + + + + + + + pubmed:23746257 + + p(HGNC:STIP1) decreases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) + + + + + + + + + pubmed:25036637 + + p(HGNC:STIP1) increases complex(p(HGNC:STIP1), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) + + + + + + + + + + + pubmed:29311797 + + p(HGNC:STIP1) decreases p(HGNC:MAPT) + + + + + + + + + pubmed:29311797 + + p(HGNC:STIP1) association bp(GO:"chaperone-mediated autophagy") + + + + + + + pubmed:25437566 + + p(HGNC:TTC1) increases bp(GO:"protein folding") + + + + + + + pubmed:25437566 + + p(HGNC:CCT5) causesNoChange a(CONSO:"huntingtin aggregates") + + + + + + + pubmed:25437566 + + p(HGNC:DNAJA4) increases a(CONSO:"huntingtin aggregates") + + + + + + + pubmed:25437566 + + p(HGNC:HSPA14) increases a(CONSO:"huntingtin aggregates") + + + + + + + pubmed:25437566 + + p(HGNC:CDC23) increases a(CONSO:"huntingtin aggregates") + + + + + + + pubmed:25437566 + + p(HGNC:CDC27) increases a(CONSO:"huntingtin aggregates") + + + + + + + + + + + + + + + + + + + + + pubmed:25036637 + + p(HGNC:HSP90AB1) directlyIncreases complex(a(MESH:"Protein Kinases"), p(HGNC:HSP90AB1)) + + + + + + + + + pubmed:29311797 + + p(HGNC:HSP90AB1) association bp(GO:"embryo development") + + + + + + + pubmed:29311797 + + p(HGNC:HSP90AB1) association bp(GO:"cell maturation") + + + + + + + pubmed:29311797 + + p(HGNC:HSP90AB1) association bp(GO:"cytoskeleton organization") + + + + + + + pubmed:29311797 + + p(HGNC:HSP90AB1) association bp(GO:"signal transduction") + + + + + + + pubmed:29311797 + + p(HGNC:HSP90AB1) association bp(GO:"adaptation of signaling pathway") + + + + + + + pubmed:27491084 + + p(HGNC:HSPA1L) decreases path(HP:Neurodegeneration) + + + + + + + pubmed:27491084 + + p(HGNC:HSPA1L) decreases path(HP:Neurodegeneration) + + + + + + + pubmed:27491084 + + p(HGNC:ATXN3, var("?")) association path(HP:Neurodegeneration) + + + + + + + pubmed:23528736 + + p(HGNC:ATXN3, var("?")) association path(MESH:"Neurodegenerative Diseases") + + + + + + + pubmed:27491084 + + p(HGNC:AR, var("?")) association path(HP:Neurodegeneration) + + + + + + + + + pubmed:27491084 + + p(UNIPROT:P15705) decreases path(CONSO:proteotoxicity) + + + + + + + pubmed:27491084 + + p(UNIPROT:P32589) regulates act(p(FPLX:HSPA)) + + + + + + + pubmed:27491084 + + p(UNIPROT:P32589) decreases path(CONSO:proteotoxicity) + + + + + + + pubmed:27491084 + + p(UNIPROT:P32589) decreases path(MESH:"Protein Aggregation, Pathological") + + + + + + + pubmed:27491084 + + p(HGNC:HSPB7) decreases path(CONSO:proteotoxicity) + + + + + + + pubmed:27491084 + + p(HGNC:HSPB7) decreases a(MESH:"Protein Aggregates") + + + + + + + pubmed:27491084 + + p(UNIPROT:Q9XXG5) decreases path(CONSO:proteotoxicity) + + + + + + + pubmed:27491084 + + p(UNIPROT:Q9XXG5) decreases a(MESH:"Protein Aggregates") + + + + + + + pubmed:27491084 + + p(UNIPROT:P12612) decreases path(CONSO:proteotoxicity) + + + + + + + pubmed:27491084 + + p(UNIPROT:P12612) decreases a(MESH:"Protein Aggregates") + + + + + + + pubmed:27491084 + + p(UNIPROT:P02829) decreases path(CONSO:proteotoxicity) + + + + + + + pubmed:27491084 + + p(UNIPROT:P02829) decreases a(MESH:"Protein Aggregates") + + + + + + + pubmed:23746257 + + bp(GO:"'de novo' protein folding") association act(p(HGNCGENEFAMILY:Chaperonins)) + + + + + + + pubmed:23746257 + + bp(GO:"'de novo' protein folding") association act(p(FPLX:HSPA)) + + + + + + + pubmed:23746257 + + bp(GO:"'de novo' protein folding") association act(p(FPLX:HSPA)) + + + + + + + pubmed:23746257 + + bp(GO:"'de novo' protein folding") association act(p(FPLX:HSP90)) + + + + + + + pubmed:27491084 + + bp(CONSO:misfolding) association p(FPLX:HSPA) + + + + + + + pubmed:27491084 + + bp(CONSO:misfolding) association p(FPLX:HSPB) + + + + + + + pubmed:24563850 + + bp(CONSO:misfolding) increases path(MESH:"Protein Aggregation, Pathological") + + + + + + + pubmed:27491084 + + p(HGNC:CRYAB) association a(CONSO:"amyloid-beta aggregates") + + + + + + + pubmed:27491084 + + p(HGNC:HSPB6) association a(CONSO:"amyloid-beta aggregates") + + + + + + + pubmed:27491084 + + a(PUBCHEM:40009526) decreases complex(a(CHEBI:ATP), p(HGNC:HSPA1A)) + + + + + + + pubmed:27491084 + + a(PUBCHEM:40009526) decreases complex(a(CHEBI:ATP), p(HGNC:HSPA1B)) + + + + + + + + + pubmed:25784053 + + p(HGNC:HSPA1A) negativeCorrelation path(MESH:"Protein Aggregation, Pathological") + + + + + + + + + pubmed:22817713 + + p(HGNC:HSPA1A) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:22817713 + + p(HGNC:HSPA1A) increases deg(a(CONSO:"Tau aggregates")) + + + + + + + + + + + pubmed:25784053 + + p(HGNC:HSPA1B) negativeCorrelation path(MESH:"Protein Aggregation, Pathological") + + + + + + + pubmed:30562574 + + composite(a(MESH:"Molecular Chaperones"), a(MESH:Proteins)) increases tloc(a(MESH:Proteins), fromLoc(GO:cytoplasm), toLoc(GO:lysosome)) + + + + + + + pubmed:30562574 + + composite(a(MESH:"Molecular Chaperones"), a(MESH:Proteins)) increases path(MESH:"Protein Unfolding") + + + + + + + pubmed:30562574 + + a(MESH:Proteome) regulates bp(GO:"chaperone-mediated autophagy") + + + + + + + + + pubmed:30562574 + + complex(p(HGNC:LAMP2), p(HGNC:PARK7)) decreases bp(GO:"cell death") + + + + + + + pubmed:30562574 + + complex(p(HGNC:LAMP2), p(HGNC:PARK7)) decreases act(a(MESH:1-Methyl-4-phenylpyridinium)) + + + + + + + + + pubmed:22908190 + + a(CONSO:"dystrophic neurite") association a(CONSO:"paired helical filaments") + + + + + + + pubmed:22908190 + + a(CONSO:"dystrophic neurite") association a(MESH:Ubiquitin) + + + + + + + pubmed:22908190 + + a(CONSO:"dystrophic neurite") association a(GO:autophagosome) + + + + + + + pubmed:22908190 + + a(CONSO:"dystrophic neurite") positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:23531502 + + a(CONSO:"dystrophic neurite") association act(a(CHEBI:acrolein)) + + + + + + + pubmed:28877763 + + a(CONSO:"dystrophic neurite") association path(MESH:"Plaque, Amyloid") + + + + + + + pubmed:24401760 + + a(CONSO:"dystrophic neurite") association path(MESH:"Plaque, Amyloid") + + + + + + + pubmed:24401760 + + a(CONSO:"dystrophic neurite") positiveCorrelation p(HGNC:ITPKB) + + + + + + + pubmed:29758300 + + a(GO:autolysosome) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:18930136 + + a(GO:autolysosome) positiveCorrelation path(MESH:"Huntington Disease") + + + + + + + pubmed:18930136 + + a(GO:autolysosome) decreases path(CONSO:Neurodegeneration) + + + + + + + pubmed:29758300 + + p(HGNCGENEFAMILY:Cathepsins) increases bp(GO:"lysosomal protein catabolic process") + + + + + + + pubmed:22908190 + + p(HGNCGENEFAMILY:Cathepsins) increases bp(GO:"lysosomal protein catabolic process") + + + + + + + pubmed:26702100 + + p(HGNCGENEFAMILY:Cathepsins) association a(GO:lysosome) + + + + + + + pubmed:29758300 + + p(HGNC:BECN1, frag("?")) association a(GO:"neurofibrillary tangle") + + + + + + + pubmed:30116051 + + p(HGNC:BECN1, frag("?")) decreases act(p(HGNC:BECN1)) + + + + + + + pubmed:29758300 + + bp(GO:"regulation of lysosomal lumen pH") association p(HGNC:PSEN1) + + + + + + + pubmed:26702100 + + a(MESH:"Vacuolar Proton-Translocating ATPases") association a(GO:lysosome) + + + + + + + pubmed:29758300 + + a(GO:organelle) increases bp(GO:"neuron cellular homeostasis") + + + + + + + pubmed:29758300 + + a(GO:organelle) increases a(MESH:Neurons) + + + + + + + pubmed:14556719 + + p(MESH:Proteins, pmod(CONSO:misfolding)) increases bp(GO:"response to unfolded protein") + + + + + + + pubmed:24457024 + + p(MESH:Proteins, pmod(CONSO:misfolding)) increases bp(CONSO:"protein aggregation") + + + + + + + + + + + pubmed:18930136 + + p(MESH:Proteins, pmod(CONSO:misfolding)) positiveCorrelation path(MESH:"Neurodegenerative Diseases") + + + + + + + pubmed:18930136 + + p(MESH:Proteins, pmod(CONSO:misfolding)) increases p(HGNC:SQSTM1) + + + + + + + pubmed:18930136 + + p(MESH:Proteins, pmod(CONSO:misfolding)) increases r(HGNC:SQSTM1) + + + + + + + pubmed:29758300 + + p(MESH:"Amyloid beta-Peptides", pmod(CONSO:misfolding)) increases path(MESH:"Alzheimer Disease") + + + + + + + pubmed:29758300 + + act(complex(GO:"TOR complex")) positiveCorrelation a(CHEBI:amyloid-beta) + + + + + + + pubmed:29626319 + + complex(GO:"TOR complex") increases bp(GO:"lysosomal microautophagy") + + + + + + + pubmed:29758300 + + path(MESH:"Niemann-Pick Diseases") association p(HGNC:MAPT) + + + + + + + pubmed:22908190 + + path(MESH:"Niemann-Pick Diseases") positiveCorrelation p(CONSO:"UBB+1") + + + + + + + pubmed:26751493 + + path(MESH:"Niemann-Pick Diseases") positiveCorrelation p(CONSO:"3R tau") + + + + + + + pubmed:26631930 + + path(MESH:"Niemann-Pick Diseases") positiveCorrelation p(CONSO:"3R tau") + + + + + + + pubmed:26751493 + + path(MESH:"Niemann-Pick Diseases") positiveCorrelation p(HGNC:PSEN1, var("p.Gly183Val")) + + + + + + + pubmed:26631930 + + path(MESH:"Niemann-Pick Diseases") isA path(MESH:Tauopathies) + + + + + + + pubmed:26631930 + + path(MESH:"Niemann-Pick Diseases") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) + + + + + + + pubmed:29758300 + + p(FPLX:MAPK) regulates p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:29191965 + + p(FPLX:MAPK) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:8702879 + + act(p(FPLX:MAPK)) increases p(HGNC:SYN1, pmod(go:0006468 ! "protein phosphorylation", Ser, 62)) + + + + + + + pubmed:8702879 + + act(p(FPLX:MAPK)) increases p(HGNC:SYN1, pmod(go:0006468 ! "protein phosphorylation", Ser, 67)) + + + + + + + pubmed:8702879 + + act(p(FPLX:MAPK)) increases p(HGNC:SYN1, pmod(go:0006468 ! "protein phosphorylation", Ser, 551)) + + + + + + + pubmed:29758300 + + composite(p(HGNC:HSPA8), p(HGNC:LAMP2)) increases tloc(p(HGNC:MAPT), fromLoc(GO:cytosol), toLoc(GO:lysosome)) + + + + + + + pubmed:29758300 + + p(HGNC:NBR1) association p(HGNC:MAPT) + + + + + + + pubmed:27181519 + + p(HGNC:NBR1) regulates bp(GO:macroautophagy) + + + + + + + pubmed:29758300 + + p(HGNC:SNCA, pmod(CONSO:misfolding)) increases a(CONSO:"alpha-synuclein oligomers") + + + + + + + pubmed:29758300 + + a(CONSO:"alpha-synuclein oligomers") increases path(CONSO:neuroinflammation) + + + + + + + pubmed:29758300 + + a(CONSO:"alpha-synuclein oligomers") increases bp(GO:"cell death") + + + + + + + pubmed:30985105 + + a(CONSO:"alpha-synuclein oligomers") negativeCorrelation a(CONSO:"alpha-synuclein aggregates") + + + + + + + pubmed:29758300 + + complex(p(HGNC:LAMP2), p(HGNC:SNCA, var("p.Ala53Thr"))) decreases bp(GO:"lysosomal protein catabolic process") + + + + + + + pubmed:29758300 + + complex(p(HGNC:LAMP2), p(HGNC:SNCA, var("p.Ala30Pro"))) decreases bp(GO:"lysosomal protein catabolic process") + + + + + + + + + pubmed:14556719 + + p(HGNC:SNCA, var("p.Ala30Pro")) association path(MESH:"Parkinson Disease") + + + + + + + pubmed:28803412 + + p(HGNC:SNCA, var("p.Ala30Pro")) increases path(MESH:"Parkinson Disease") + + + + + + + pubmed:14556719 + + p(HGNC:SNCA, var("p.Ala30Pro")) increases a(CONSO:"alpha-synuclein fibrils") + + + + + + + pubmed:28803412 + + p(HGNC:SNCA, var("p.Ala30Pro")) increases path(MESH:"Lewy Body Disease") + + + + + + + pubmed:29758300 + + p(HGNC:TARDBP, pmod(CONSO:misfolding)) positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:29758300 + + p(HGNC:TARDBP, pmod(CONSO:misfolding)) positiveCorrelation path(MESH:"Frontotemporal Dementia") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation")) association p(HGNC:GSK3A) + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation")) increases p(CONSO:"TDP-43 aggregates") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation"), loc(GO:"inclusion body")) association path(MESH:"Lewy Body Disease") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation"), loc(GO:"inclusion body")) association path(MESH:"Supranuclear Palsy, Progressive") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation"), loc(GO:"inclusion body")) association path(MESH:"Pick Disease of the Brain") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation"), loc(GO:"inclusion body")) association path(MESH:Sclerosis) + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation"), loc(GO:"inclusion body")) association path(MESH:"Alzheimer Disease") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation"), loc(GO:"inclusion body")) association path(MESH:"Huntington Disease") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation"), loc(GO:"inclusion body")) association path(MESH:"Parkinson Disease") + + + + + + + pubmed:29758300 + + a(CHEBI:lipid) regulates bp(GO:"energy homeostasis") + + + + + + + pubmed:29758300 + + a(CHEBI:lipid) regulates bp(GO:"intracellular signal transduction") + + + + + + + pubmed:29758300 + + a(CHEBI:lipid) regulates bp(GO:macroautophagy) + + + + + + + pubmed:29758300 + + a(CHEBI:lipid) regulates bp(GO:"amyloid-beta metabolic process") + + + + + + + + + pubmed:29758300 + + a(CHEBI:lipid) negativeCorrelation bp(GO:autophagy) + + + + + + + pubmed:22908190 + + a(CHEBI:lipid) positiveCorrelation act(p(HGNC:RAB5A)) + + + + + + + pubmed:22908190 + + a(CHEBI:lipid) positiveCorrelation bp(GO:endocytosis) + + + + + + + + + + + + + pubmed:24561250 + + a(CHEBI:"fatty acid") increases act(complex(GO:"inflammasome complex")) + + + + + + + pubmed:29758300 + + a(CHEBI:sphingolipid) association path(MESH:"Alzheimer Disease") + + + + + + + pubmed:29758300 + + a(CHEBI:sphingolipid) regulates act(complex(GO:"gamma-secretase complex")) + + + + + + + pubmed:29758300 + + a(CHEBI:sphingolipid) association bp(GO:"amyloid-beta metabolic process") + + + + + + + + + + + pubmed:29758300 + + rxn(reactants(a(MESH:Sphingomyelins)), products(a(CHEBI:ceramide))) increases a(CHEBI:amyloid-beta) + + + + + + + pubmed:29758300 + + complex(a(CHEBI:lipid), p(HGNC:MAPT)) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:29758300 + + complex(a(MESH:"Lipid Bilayers"), p(HGNC:MAPT)) association a(CONSO:"Tau aggregates") + + + + + + + + + pubmed:29758300 + + p(FPLX:AMPK) increases p(HGNC:ULK1, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:23528736 + + p(FPLX:AMPK) increases p(HGNC:ULK1, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + + + pubmed:30116051 + + p(FPLX:AMPK) increases bp(GO:macroautophagy) + + + + + + + pubmed:30116051 + + act(p(FPLX:AMPK)) increases bp(GO:macroautophagy) + + + + + + + pubmed:30116051 + + act(p(FPLX:AMPK)) increases bp(GO:macroautophagy) + + + + + + + pubmed:30116051 + + p(FPLX:AMPK) decreases bp(GO:mitophagy) + + + + + + + pubmed:30116051 + + p(FPLX:AMPK) increases p(HGNC:ULK1, pmod(go:0006468 ! "protein phosphorylation", Ser, 317)) + + + + + + + pubmed:30116051 + + p(FPLX:AMPK) increases p(HGNC:ULK1, pmod(go:0006468 ! "protein phosphorylation", Ser, 777)) + + + + + + + pubmed:30116051 + + p(FPLX:AMPK) increases p(FPLX:mTORC1, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:30116051 + + p(FPLX:AMPK) increases a(CHEBI:"NAD(+)") + + + + + + + pubmed:30116051 + + act(p(FPLX:AMPK)) increases bp(GO:autophagy) + + + + + + + pubmed:23528736 + + p(FPLX:AMPK) increases bp(GO:autophagy) + + + + + + + + + pubmed:30116051 + + act(p(FPLX:AMPK)) increases act(p(HGNC:SIRT1)) + + + + + + + + + pubmed:23528736 + + p(FPLX:AMPK) decreases act(p(FPLX:mTORC1)) + + + + + + + pubmed:22419736 + + act(p(FPLX:AMPK)) association p(MESH:"Acetyl-CoA Carboxylase") + + + + + + + pubmed:22419736 + + act(p(FPLX:AMPK)) negativeCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:22419736 + + p(FPLX:AMPK) negativeCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:22419736 + + act(p(FPLX:AMPK)) increases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) + + + + + + + pubmed:22419736 + + act(p(FPLX:AMPK)) increases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) + + + + + + + pubmed:22419736 + + act(p(FPLX:AMPK)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) + + + + + + + pubmed:22419736 + + act(p(FPLX:AMPK)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) + + + + + + + pubmed:22419736 + + act(p(FPLX:AMPK)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + + + + + + + pubmed:22419736 + + act(p(FPLX:AMPK)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + + + + + + + pubmed:22419736 + + p(FPLX:AMPK) negativeCorrelation act(p(HGNC:GSK3B)) + + + + + + + pubmed:24869773 + + p(FPLX:AMPK) regulates complex(a(GO:microtubule), p(HGNC:MAPT)) + + + + + + + pubmed:29758300 + + composite(p(FPLX:AMPK), p(HGNC:TSC2)) decreases act(p(HGNC:MTOR)) + + + + + + + pubmed:29758300 + + p(FPLX:mTORC1) increases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:29758300 + + p(FPLX:mTORC1) decreases act(p(HGNC:TFEB)) + + + + + + + pubmed:30116051 + + p(FPLX:mTORC1) decreases tloc(p(HGNC:TFEB), fromLoc(MESH:Cytoplasm), toLoc(MESH:"Cell Nucleus")) + + + + + + + pubmed:30116051 + + act(p(FPLX:mTORC1)) increases act(p(HGNC:TFEB)) + + + + + + + pubmed:30116051 + + p(FPLX:mTORC1) increases bp(GO:macroautophagy) + + + + + + + pubmed:30116051 + + p(FPLX:mTORC1) decreases bp(GO:macroautophagy) + + + + + + + pubmed:30116051 + + p(FPLX:mTORC1) decreases bp(GO:macroautophagy) + + + + + + + pubmed:30116051 + + p(FPLX:mTORC1) increases bp(GO:macroautophagy) + + + + + + + pubmed:30116051 + + p(FPLX:mTORC1) decreases bp(GO:mitophagy) + + + + + + + + + pubmed:30116051 + + p(FPLX:mTORC1) increases p(HGNC:ULK1, pmod(go:0006468 ! "protein phosphorylation", Ser, 757)) + + + + + + + pubmed:30116051 + + act(p(FPLX:mTORC1)) increases act(p(HGNC:NFE2L2)) + + + + + + + pubmed:30116051 + + p(FPLX:mTORC1) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + + + + + + + pubmed:30116051 + + p(FPLX:mTORC1) decreases bp(GO:"proteasome assembly") + + + + + + + pubmed:23528736 + + p(FPLX:mTORC1) decreases bp(GO:autophagy) + + + + + + + pubmed:23528736 + + act(p(FPLX:mTORC1), ma(go:0016301 ! "kinase activity")) increases p(HGNC:ULK1, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:23528736 + + act(p(FPLX:mTORC1)) increases p(HGNC:MAPT) + + + + + + + pubmed:30108137 + + act(p(FPLX:mTORC1)) increases p(MGI:Tfeb, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:29758300 + + complex(p(HGNC:TFEB), p(INTERPRO:"cAMP response element binding (CREB) protein")) increases bp(GO:macroautophagy) + + + + + + + pubmed:29758300 + + complex(p(HGNC:TFEB), p(INTERPRO:"cAMP response element binding (CREB) protein")) increases a(GO:lysosome) + + + + + + + + + pubmed:29758300 + + composite(p(HGNC:PTEN), p(HGNC:TFEB)) increases bp(GO:macroautophagy) + + + + + + + pubmed:29758300 + + p(HGNC:PICALM, var("?")) association path(MESH:"Alzheimer Disease") + + + + + + + pubmed:26195256 + + p(HGNC:PICALM, var("?")) association path(MESH:"Alzheimer Disease") + + + + + + + pubmed:29758300 + + p(HGNC:TREM2, var("?")) increases path(MESH:"Alzheimer Disease") + + + + + + + pubmed:26195256 + + p(HGNC:TREM2, var("?")) association path(MESH:"Alzheimer Disease") + + + + + + + pubmed:29758300 + + p(HGNC:VPS35) regulates act(p(HGNC:TREM2)) + + + + + + + + + + + pubmed:29758300 + + p(HGNC:VPS35) directlyIncreases complex(p(HGNC:SORL1), p(HGNC:VPS35)) + + + + + + + pubmed:29758300 + + p(HGNC:VPS35, var("?")) decreases bp(GO:macroautophagy) + + + + + + + pubmed:29758300 + + p(HGNC:VPS35, var("?")) decreases act(a(GO:mitochondrion)) + + + + + + + pubmed:29758300 + + p(HGNC:VPS35, var("?")) association path(MESH:"Alzheimer Disease") + + + + + + + pubmed:29758300 + + p(HGNC:VPS35, var("?")) association path(MESH:"Parkinson Disease") + + + + + + + pubmed:29758300 + + a(GO:mitochondrion) regulates bp(GO:"energy homeostasis") + + + + + + + pubmed:23528736 + + act(a(GO:mitochondrion)) increases a(CHEBI:"reactive oxygen species") + + + + + + + pubmed:25987199 + + act(a(GO:mitochondrion)) positiveCorrelation act(p(MGI:Ppargc1a)) + + + + + + + + + pubmed:29758300 + + p(HGNC:PSEN1, var("p.Met146Leu")) decreases bp(GO:autophagy) + + + + + + + pubmed:29758300 + + p(HGNC:MAPT, var("p.Ala152Thr")) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:29758300 + + p(HGNC:MAPT, var("p.Ala152Thr")) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + + + + + + + pubmed:29758300 + + p(HGNC:MAPT, var("p.Ala152Thr")) increases bp(GO:macroautophagy) + + + + + + + + + pubmed:27594586 + + p(HGNC:MAPT, var("p.Ala152Thr")) increases p(HGNC:MAP2) + + + + + + + pubmed:27594586 + + p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange a(GO:"symmetric, GABA-ergic, inhibitory synapse") + + + + + + + pubmed:27594586 + + p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange p(HGNC:SLC17A7) + + + + + + + pubmed:27594586 + + p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange p(HGNC:MAPT) + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, var("p.Ala152Thr")) decreases act(p(HGNC:MAPT)) + + + + + + + pubmed:27594586 + + p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange p(HGNC:DLGAP4) + + + + + + + pubmed:27594586 + + p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange bp(MESH:"Membrane Potentials") + + + + + + + pubmed:27594586 + + p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange bp(GO:"neuron differentiation") + + + + + + + pubmed:27594586 + + p(HGNC:MAPT, var("p.Ala152Thr")) increases act(p(HGNC:MMP9)) + + + + + + + pubmed:27594586 + + p(HGNC:MAPT, var("p.Ala152Thr")) increases tloc(p(HGNC:MMP9), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:27594586 + + p(HGNC:MAPT, var("p.Ala152Thr")) increases tloc(p(HGNC:MMP9), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:27594586 + + p(HGNC:MAPT, var("p.Ala152Thr")) increases act(p(HGNC:MMP9)) + + + + + + + pubmed:27594586 + + p(HGNC:MAPT, var("p.Ala152Thr")) increases tloc(p(HGNC:MMP9), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:27594586 + + p(HGNC:MAPT, var("p.Ala152Thr")) increases tloc(p(HGNC:MMP2), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:27594586 + + p(HGNC:MAPT, var("p.Ala152Thr")) increases act(p(HGNC:MMP2)) + + + + + + + pubmed:27594586 + + p(HGNC:MAPT, var("p.Ala152Thr")) increases tloc(p(HGNC:MMP2), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:27594586 + + p(HGNC:MAPT, var("p.Ala152Thr")) increases r(HGNC:MMP9) + + + + + + + pubmed:27594586 + + p(HGNC:MAPT, var("p.Ala152Thr")) increases r(HGNC:MMP9) + + + + + + + pubmed:27594586 + + p(HGNC:MAPT, var("p.Ala152Thr")) increases r(HGNC:MMP2) + + + + + + + pubmed:27594586 + + p(HGNC:MAPT, var("p.Ala152Thr")) increases r(HGNC:MMP2) + + + + + + + pubmed:27594586 + + p(HGNC:MAPT, var("p.Ala152Thr")) increases bp(GO:"neuron death") + + + + + + + + + + + pubmed:27594586 + + p(HGNC:MAPT, var("p.Ala152Thr")) increases p(FPLX:ERK, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:27594586 + + p(HGNC:MAPT, var("p.Ala152Thr")) increases p(CONSO:CONSO00045) + + + + + + + pubmed:27594586 + + p(HGNC:MAPT, var("p.Ala152Thr")) decreases p(CONSO:CONSO00044) + + + + + + + pubmed:29024336 + + p(HGNC:MAPT, var("p.Ala152Thr")) decreases deg(p(MGI:Mapt)) + + + + + + + pubmed:29191965 + + p(HGNC:MAPT, var("p.Ala152Thr")) association path(MESH:"Supranuclear Palsy, Progressive") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, var("p.Ala152Thr")) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, var("p.Ala152Thr")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, var("p.Ala152Thr")) decreases bp(GO:"microtubule polymerization") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, var("p.Ala152Thr")) increases a(CONSO:"Tau oligomers") + + + + + + + pubmed:29758300 + + composite(a(CHEBI:sirolimus), p(HGNC:MAPT, var("p.Ala152Thr"))) increases bp(GO:"cell death") + + + + + + + pubmed:27594586 + + composite(a(CHEBI:sirolimus), p(HGNC:MAPT, var("p.Ala152Thr"))) increases bp(GO:"neuron death") + + + + + + + pubmed:29758300 + + path(MESH:"Niemann-Pick Disease, Type C") negativeCorrelation bp(GO:macroautophagy) + + + + + + + pubmed:29758300 + + path(MESH:"Spastic Paraplegia, Hereditary") negativeCorrelation bp(GO:macroautophagy) + + + + + + + pubmed:29758300 + + a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:macroautophagy) + + + + + + + pubmed:30116051 + + a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:macroautophagy) + + + + + + + pubmed:18930136 + + a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:autophagy) + + + + + + + pubmed:30145931 + + a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:autophagy) + + + + + + + pubmed:23528736 + + a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:autophagy) + + + + + + + pubmed:29626319 + + a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:autophagy) + + + + + + + pubmed:29626319 + + a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:autophagy) + + + + + + + pubmed:27181519 + + a(CHEBI:"alpha,alpha-trehalose") association bp(GO:autophagy) + + + + + + + pubmed:18930136 + + a(CHEBI:"alpha,alpha-trehalose") decreases path(CONSO:Neurodegeneration) + + + + + + + pubmed:30145931 + + a(CHEBI:"alpha,alpha-trehalose") decreases p(HGNC:MAPT) + + + + + + + pubmed:30145931 + + a(CHEBI:"alpha,alpha-trehalose") decreases p(HGNC:MAPT, loc(MESH:Dendrites)) + + + + + + + pubmed:29626319 + + a(CHEBI:"alpha,alpha-trehalose") decreases p(HGNC:MAPT) + + + + + + + pubmed:30145931 + + a(CHEBI:"alpha,alpha-trehalose") decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:30116051 + + a(CHEBI:"alpha,alpha-trehalose") decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:23528736 + + a(CHEBI:"alpha,alpha-trehalose") decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:30116051 + + a(CHEBI:"alpha,alpha-trehalose") decreases act(p(HGNC:SLC2A9)) + + + + + + + pubmed:30116051 + + a(CHEBI:"alpha,alpha-trehalose") increases act(p(FPLX:AMPK)) + + + + + + + pubmed:30116051 + + a(CHEBI:"alpha,alpha-trehalose") decreases bp(HP:Neurodegeneration) + + + + + + + pubmed:30116051 + + a(CHEBI:"alpha,alpha-trehalose") decreases a(CONSO:"alpha-synuclein aggregates") + + + + + + + pubmed:30116051 + + a(CHEBI:"alpha,alpha-trehalose") decreases a(CONSO:"huntingtin aggregates") + + + + + + + pubmed:30116051 + + a(CHEBI:"alpha,alpha-trehalose") decreases a(CONSO:"amyloid-beta aggregates") + + + + + + + pubmed:30116051 + + a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:"motor behavior") + + + + + + + pubmed:30116051 + + a(CHEBI:"alpha,alpha-trehalose") increases bp(GO:cognition) + + + + + + + pubmed:23528736 + + a(CHEBI:"alpha,alpha-trehalose") decreases bp(GO:"neuron apoptotic process") + + + + + + + pubmed:29626319 + + a(CHEBI:"alpha,alpha-trehalose") decreases a(CHEBI:amyloid-beta) + + + + + + + pubmed:29626319 + + a(CHEBI:"alpha,alpha-trehalose") increases p(HGNC:BAG3) + + + + + + + pubmed:29758300 + + a(CHEBI:epothilone) decreases path(MESH:Tauopathies) + + + + + + + pubmed:29758300 + + a(CHEBI:epothilone) increases bp(GO:cognition) + + + + + + + pubmed:14556719 + + composite(a(CHEBI:ATP), p(HGNC:UBA1)) increases act(a(MESH:Ubiquitin)) + + + + + + + pubmed:22908190 + + composite(a(CHEBI:ATP), p(HGNC:UBA1)) increases act(a(MESH:Ubiquitin)) + + + + + + + + + + + pubmed:14556719 + + act(p(HGNC:UBA1)) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + + + pubmed:18930136 + + p(HGNC:UBA1) increases bp(GO:autophagy) + + + + + + + pubmed:18930136 + + p(HGNC:UBA1) increases bp(GO:"protein ubiquitination") + + + + + + + pubmed:29626319 + + p(HGNC:UBA1) increases deg(a(MESH:Proteins)) + + + + + + + + + pubmed:14556719 + + act(a(MESH:Ubiquitin)) increases complex(a(MESH:Ubiquitin), p(HGNC:UBA1)) + + + + + + + + + + + + + pubmed:22908190 + + act(a(MESH:Ubiquitin)) increases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) + + + + + + + + + + + + + + + + + + + pubmed:22908190 + + a(MESH:Ubiquitin) association a(CONSO:"paired helical filaments") + + + + + + + pubmed:22908190 + + a(MESH:Ubiquitin) association a(GO:"neurofibrillary tangle") + + + + + + + pubmed:22908190 + + a(MESH:Ubiquitin) association a(CONSO:"dystrophic neurite") + + + + + + + pubmed:22908190 + + a(MESH:Ubiquitin) association path(CONSO:"granulovacuolar degeneration") + + + + + + + pubmed:22908190 + + a(MESH:Ubiquitin) association path(CONSO:"granulovacuolar degeneration") + + + + + + + pubmed:22908190 + + a(MESH:Ubiquitin) association a(MESH:"Neuropil Threads") + + + + + + + pubmed:22908190 + + a(MESH:Ubiquitin) association a(GO:"Lewy body") + + + + + + + pubmed:22908190 + + a(MESH:Ubiquitin) association a(GO:"Lewy body") + + + + + + + pubmed:22908190 + + a(MESH:Ubiquitin) association a(GO:"Pick body") + + + + + + + + + pubmed:22908190 + + a(MESH:Ubiquitin) increases tloc(a(MESH:Proteins), fromLoc(GO:cytoplasm), toLoc(GO:"multivesicular body")) + + + + + + + pubmed:24457024 + + a(MESH:Ubiquitin) regulates bp(GO:signaling) + + + + + + + pubmed:24457024 + + a(MESH:Ubiquitin) regulates bp(GO:endocytosis) + + + + + + + pubmed:24457024 + + a(MESH:Ubiquitin) regulates bp(GO:macroautophagy) + + + + + + + pubmed:24457024 + + a(MESH:Ubiquitin) regulates bp(GO:"DNA repair") + + + + + + + pubmed:24457024 + + act(a(MESH:Ubiquitin)) regulates bp(GO:"cellular homeostasis") + + + + + + + + + + + + + + + + + + + pubmed:24457024 + + complex(a(MESH:Ubiquitin), p(HGNC:UBA1)) increases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) + + + + + + + pubmed:24457024 + + complex(a(MESH:Ubiquitin), p(HGNC:UBA1)) increases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) + + + + + + + pubmed:14556719 + + p(HGNC:UBA2) decreases complex(a(MESH:Ubiquitin), p(HGNC:UBA1)) + + + + + + + pubmed:14556719 + + p(HGNC:UBA2) increases complex(a(MESH:Ubiquitin), p(HGNC:UBA3)) + + + + + + + pubmed:14556719 + + p(HGNC:UBA2) increases complex(a(MESH:Ubiquitin), p(INTERPRO:"HECT domain")) + + + + + + + + + + + pubmed:14556719 + + act(p(HGNC:UBA2)) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:14556719 + + p(HGNC:UBA2) increases p(HGNC:HTT, pmod(go:0016567 ! "protein ubiquitination")) + + + + + + + + + + + pubmed:24457024 + + p(HGNC:UBA2) increases bp(GO:"protein ubiquitination") + + + + + + + + + pubmed:24457024 + + complex(a(MESH:Ubiquitin), p(HGNC:UBA3)) increases act(p(HGNC:UBA2)) + + + + + + + + + + + pubmed:14556719 + + p(HGNC:UBA3) increases bp(GO:"protein ubiquitination") + + + + + + + pubmed:14556719 + + p(HGNC:UBA3) increases bp(GO:"protein ubiquitination") + + + + + + + pubmed:24457024 + + p(HGNC:UBA3) increases bp(GO:"protein ubiquitination") + + + + + + + pubmed:24457024 + + p(HGNC:UBA3) increases bp(GO:"protein ubiquitination") + + + + + + + pubmed:24457024 + + p(HGNC:UBA3) increases bp(GO:"protein ubiquitination") + + + + + + + pubmed:14556719 + + p(HGNC:UBA3) association bp(GO:proteolysis) + + + + + + + + + pubmed:22908190 + + p(HGNC:UBA3) increases complex(a(MESH:Proteins), a(MESH:Ubiquitin), p(HGNC:UBA2), p(HGNC:UBA3)) + + + + + + + pubmed:24457024 + + p(HGNC:UBA3) increases act(p(HGNC:UBA2)) + + + + + + + pubmed:24457024 + + p(HGNC:UBA3) regulates complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) + + + + + + + pubmed:24457024 + + p(HGNC:UBA3) regulates bp(GO:"protein polyubiquitination") + + + + + + + + + + + pubmed:24457024 + + p(INTERPRO:"HECT domain") increases complex(a(MESH:Ubiquitin), p(HGNC:UBA3)) + + + + + + + pubmed:14556719 + + p(INTERPRO:"E3 ubiquitin ligase RBR family") decreases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) + + + + + + + pubmed:14556719 + + p(INTERPRO:"E3 ubiquitin ligase RBR family") increases complex(a(MESH:Proteins), a(MESH:Ubiquitin), p(HGNC:UBA3)) + + + + + + + pubmed:24457024 + + p(INTERPRO:"E3 ubiquitin ligase RBR family") increases complex(a(MESH:Ubiquitin), p(HGNC:UBA3)) + + + + + + + pubmed:24457024 + + complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) increases act(p(HGNC:UBA2)) + + + + + + + pubmed:14556719 + + bp(GO:"protein K48-linked ubiquitination") increases act(complex(GO:"proteasome complex")) + + + + + + + pubmed:14556719 + + bp(GO:"protein K63-linked ubiquitination") increases act(complex(GO:"proteasome complex")) + + + + + + + pubmed:22908190 + + bp(GO:"protein K63-linked ubiquitination") association a(GO:"neurofibrillary tangle") + + + + + + + pubmed:18930136 + + bp(GO:"protein K63-linked ubiquitination") increases act(p(HGNC:SQSTM1)) + + + + + + + pubmed:18930136 + + bp(GO:"protein K63-linked ubiquitination") increases act(p(HGNC:HDAC6)) + + + + + + + pubmed:18930136 + + bp(GO:"protein K63-linked ubiquitination") increases bp(GO:autophagy) + + + + + + + pubmed:14556719 + + p(HGNC:MOCS3) increases bp(GO:"protein polyubiquitination") + + + + + + + + + + + + + pubmed:22908190 + + p(CONSO:"20 S Proteasome") increases deg(p(HGNC:MAPT)) + + + + + + + + + pubmed:22908190 + + p(CONSO:"20 S Proteasome") increases complex(a(CONSO:"Tau aggregates"), p(CONSO:"20 S Proteasome")) + + + + + + + pubmed:16816118 + + act(p(CONSO:"20 S Proteasome")) increases deg(p(RGD:Mapt, pmod(CONSO:hyperphosphorylation))) + + + + + + + pubmed:16816118 + + act(p(CONSO:"20 S Proteasome")) increases deg(p(RGD:Mapt)) + + + + + + + + + pubmed:14556719 + + complex(GO:"proteasome regulatory particle") increases bp(GO:"protein unfolding") + + + + + + + + + + + pubmed:14556719 + + p(HGNC:PSMD4) increases complex(a(MESH:Ubiquitin), p(HGNC:PSMD4)) + + + + + + + pubmed:14556719 + + p(HGNC:PSMD4) association p(HGNC:PRKN) + + + + + + + pubmed:24457024 + + p(HGNC:PSMD4) increases complex(a(GO:"proteasome complex"), p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination"))) + + + + + + + + + + + pubmed:25036637 + + p(HGNC:PSMD4) directlyIncreases complex(p(HGNC:PSMD4), p(HGNC:USP14)) + + + + + + + + + pubmed:25036637 + + p(HGNC:PSMD4) directlyIncreases complex(p(HGNC:PSMC1), p(HGNC:PSMD4)) + + + + + + + + + pubmed:25036637 + + p(HGNC:PSMD4) directlyIncreases complex(p(HGNC:PSMD2), p(HGNC:PSMD4)) + + + + + + + + + pubmed:25036637 + + p(HGNC:PSMD4) directlyIncreases complex(p(HGNC:PRPS2), p(HGNC:PSMD4)) + + + + + + + + + pubmed:25036637 + + p(HGNC:PSMD4) directlyIncreases complex(p(HGNC:PSMA5), p(HGNC:PSMD4)) + + + + + + + + + + + + + pubmed:14556719 + + p(HGNC:PSMC3) increases complex(a(MESH:Ubiquitin), p(HGNC:PSMC3)) + + + + + + + pubmed:14556719 + + deg(complex(a(MESH:Proteins), a(MESH:Ubiquitin))) increases a(CHEBI:peptide) + + + + + + + pubmed:14556719 + + deg(complex(a(MESH:Proteins), a(MESH:Ubiquitin))) increases a(MESH:Ubiquitin) + + + + + + + pubmed:14556719 + + complex(a(MESH:"Molecular Chaperones"), a(MESH:Proteins)) increases bp(GO:"protein stabilization") + + + + + + + pubmed:27181519 + + bp(GO:"DNA repair") association p(HGNC:FUS) + + + + + + + pubmed:25036637 + + bp(GO:"gene silencing") association p(HGNC:DCP1A) + + + + + + + pubmed:25036637 + + bp(GO:"gene silencing") association p(HGNC:EDC3) + + + + + + + pubmed:25036637 + + bp(GO:"gene silencing") association p(HGNC:DDX6) + + + + + + + pubmed:14556719 + + path(MESH:Sepsis) increases bp(GO:"protein catabolic process") + + + + + + + pubmed:14556719 + + path(MESH:Acidosis) increases bp(GO:"protein catabolic process") + + + + + + + pubmed:14556719 + + a(MESH:Denervation) increases bp(GO:"protein catabolic process") + + + + + + + pubmed:14556719 + + p(HGNC:NEDD8) increases complex(a(GO:"SCF ubiquitin ligase complex"), p(HGNC:UBA2)) + + + + + + + + + pubmed:14556719 + + p(HGNC:SUMO1) increases p(HGNC:NFKBIA, pmod(go:0016925 ! "protein sumoylation")) + + + + + + + pubmed:27716675 + + p(HGNC:SUMO1) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:23229893 + + p(HGNC:SUMO1) association a(GO:lysosome) + + + + + + + + + pubmed:19323834 + + p(HGNC:SUMO1) partOf complex(p(FPLX:CEBP), p(HGNC:SUMO1)) + + + + + + + pubmed:18675254 + + p(HGNC:SUMO1) increases p(HGNC:APP, pmod(go:0016925 ! "protein sumoylation", Lys, 587)) + + + + + + + pubmed:18675254 + + p(HGNC:SUMO1) increases p(HGNC:APP, pmod(go:0016925 ! "protein sumoylation", Lys, 595)) + + + + + + + pubmed:16464864 + + p(HGNC:SUMO1) increases p(HGNC:MAPT, pmod(go:0016925 ! "protein sumoylation", Lys, 340)) + + + + + + + pubmed:16464864 + + p(HGNC:SUMO1) increases p(HGNC:SNCA, pmod(go:0016925 ! "protein sumoylation")) + + + + + + + pubmed:14556719 + + p(HGNC:NFKBIA, pmod(go:0016925 ! "protein sumoylation")) decreases bp(GO:"protein ubiquitination") + + + + + + + pubmed:14556719 + + p(UNIPROT:P32628) increases tloc(p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination")), fromLoc(GO:cytosol), toLoc(GO:"proteasome complex")) + + + + + + + pubmed:14556719 + + p(UNIPROT:P48510) increases tloc(p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination")), fromLoc(GO:cytosol), toLoc(GO:"proteasome complex")) + + + + + + + pubmed:14556719 + + complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation a(MESH:"Neurofibrillary Tangles") + + + + + + + pubmed:14556719 + + complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation a(GO:"Bunina body") + + + + + + + pubmed:14556719 + + complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation path(MESH:"Huntington Disease") + + + + + + + pubmed:14556719 + + complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation path(MESH:"Spinocerebellar Ataxias") + + + + + + + pubmed:14556719 + + complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation path(MESH:"Bulbo-Spinal Atrophy, X-Linked") + + + + + + + pubmed:14556719 + + complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) positiveCorrelation a(MESH:"Lewy Bodies") + + + + + + + + + + + pubmed:14556719 + + a(MESH:"Inclusion Bodies") negativeCorrelation path(MESH:"Parkinsonian Disorders") + + + + + + + pubmed:14556719 + + a(MESH:"Inclusion Bodies") association p(HGNC:SNCA) + + + + + + + pubmed:14556719 + + a(MESH:"Inclusion Bodies") association p(HGNC:CREBBP) + + + + + + + + + pubmed:30837838 + + a(MESH:"Inclusion Bodies") association p(HGNC:TARDBP, frag("274_414")) + + + + + + + pubmed:14556719 + + complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation a(MESH:"Neurofibrillary Tangles") + + + + + + + pubmed:14556719 + + complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation a(GO:"Bunina body") + + + + + + + pubmed:14556719 + + complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation path(MESH:"Huntington Disease") + + + + + + + pubmed:14556719 + + complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation path(MESH:"Spinocerebellar Ataxias") + + + + + + + pubmed:14556719 + + complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation path(MESH:"Bulbo-Spinal Atrophy, X-Linked") + + + + + + + pubmed:14556719 + + complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) positiveCorrelation a(MESH:"Lewy Bodies") + + + + + + + + + + + + + + + + + + + + + + + pubmed:14556719 + + path(MESH:"Spinocerebellar Ataxias") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) + + + + + + + pubmed:14556719 + + path(MESH:"Spinocerebellar Ataxias") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) + + + + + + + pubmed:14556719 + + a(MESH:"Lewy Bodies") positiveCorrelation complex(a(MESH:"Inclusion Bodies"), a(MESH:Ubiquitin)) + + + + + + + pubmed:14556719 + + a(MESH:"Lewy Bodies") positiveCorrelation complex(a(GO:"proteasome complex"), a(MESH:"Inclusion Bodies")) + + + + + + + pubmed:14556719 + + a(MESH:"Lewy Bodies") association a(GO:"dopaminergic synapse") + + + + + + + pubmed:14556719 + + a(MESH:"Lewy Bodies") negativeCorrelation path(MESH:"Parkinsonian Disorders") + + + + + + + pubmed:14556719 + + a(MESH:"Lewy Bodies") negativeCorrelation path(MESH:"Parkinsonian Disorders") + + + + + + + pubmed:14556719 + + a(MESH:"Lewy Bodies") association a(CONSO:"alpha-synuclein aggregates") + + + + + + + pubmed:14556719 + + a(MESH:"Lewy Bodies") association path(MESH:"Parkinson Disease") + + + + + + + pubmed:14556719 + + path(MESH:"Parkinsonian Disorders") negativeCorrelation a(MESH:"Lewy Bodies") + + + + + + + pubmed:14556719 + + path(MESH:"Parkinsonian Disorders") negativeCorrelation a(MESH:"Lewy Bodies") + + + + + + + pubmed:14556719 + + path(MESH:"Parkinsonian Disorders") positiveCorrelation p(HGNC:GPR37) + + + + + + + pubmed:14556719 + + path(MESH:"Parkinsonian Disorders") association p(HGNC:SNCA, var("?")) + + + + + + + pubmed:14556719 + + path(MESH:"Parkinsonian Disorders") negativeCorrelation a(MESH:"Inclusion Bodies") + + + + + + + pubmed:14556719 + + path(MESH:"Parkinsonian Disorders") association p(HGNC:PRKN, var("p.Lys161Asn")) + + + + + + + pubmed:14556719 + + path(MESH:"Parkinsonian Disorders") positiveCorrelation a(CONSO:"alpha-synuclein aggregates") + + + + + + + pubmed:14556719 + + path(MESH:"Parkinsonian Disorders") increases path(CONSO:Neurodegeneration) + + + + + + + pubmed:14556719 + + path(MESH:"Parkinsonian Disorders") association g(HGNC:PARK7, var("?")) + + + + + + + pubmed:14556719 + + path(MESH:"Parkinsonian Disorders") association p(HGNC:PARK7, var("p.Leu166Pro")) + + + + + + + pubmed:30126037 + + path(MESH:"Parkinsonian Disorders") association path(MESH:"Supranuclear Palsy, Progressive") + + + + + + + pubmed:14556719 + + p(HGNC:PRKN, var("p.Arg42?")) decreases complex(a(GO:"proteasome complex"), p(HGNC:PRKN)) + + + + + + + pubmed:14556719 + + p(HGNC:PRKN, var("p.Arg42?")) increases path(MESH:"Parkinsonian Disorders") + + + + + + + pubmed:14556719 + + complex(a(GO:"proteasome complex"), p(HGNC:PRKN)) decreases path(MESH:"Parkinsonian Disorders") + + + + + + + + + pubmed:14556719 + + p(INTERPRO:"IBR domain", var("?")) decreases act(p(HGNC:PRKN)) + + + + + + + + + pubmed:14556719 + + complex(p(HGNC:PRKN), p(HGNC:STUB1)) increases act(p(HGNC:PRKN)) + + + + + + + pubmed:14556719 + + complex(p(HGNC:SEPT5), p(HGNC:STX1A)) decreases bp(GO:exocytosis) + + + + + + + + + pubmed:29191965 + + a(GO:"synaptic vesicle") association complex(p(HGNC:KLC3), p(HGNC:MAPT)) + + + + + + + + + pubmed:14556719 + + p(HGNC:GPR37) association p(HGNC:PRKN) + + + + + + + + + pubmed:14556719 + + p(HGNC:GPR37) increases p(HGNC:GPR37, pmod(CONSO:misfolding)) + + + + + + + pubmed:14556719 + + p(HGNC:GPR37) positiveCorrelation bp(GO:"cell death") + + + + + + + pubmed:14556719 + + p(HGNC:GPR37) positiveCorrelation path(MESH:"Parkinsonian Disorders") + + + + + + + pubmed:14556719 + + bp(GO:"response to unfolded protein") increases bp(GO:"cell death") + + + + + + + pubmed:14556719 + + bp(GO:"response to unfolded protein") increases bp(GO:"response to endoplasmic reticulum stress") + + + + + + + pubmed:14556719 + + bp(GO:"response to unfolded protein") increases a(MESH:"Molecular Chaperones") + + + + + + + pubmed:14556719 + + bp(GO:"response to unfolded protein") positiveCorrelation bp(MESH:"Osmolar Concentration") + + + + + + + pubmed:23746257 + + bp(GO:"response to unfolded protein") regulates bp(CONSO:Proteostasis) + + + + + + + pubmed:14556719 + + p(MESH:Proteins, var("?")) increases bp(GO:"response to unfolded protein") + + + + + + + pubmed:14556719 + + composite(p(HGNC:PRKN), p(HGNC:UBE2G1), p(HGNC:UBE2J1)) increases deg(p(HGNC:GPR37)) + + + + + + + + + + + pubmed:14556719 + + a(CHEBI:"alkylating agent") increases bp(GO:"response to unfolded protein") + + + + + + + pubmed:14556719 + + bp(MESH:"Ultraviolet Rays") increases bp(GO:"response to unfolded protein") + + + + + + + pubmed:14556719 + + p(HGNC:SNCA, pmod(go:0006493 ! "protein O-linked glycosylation")) association p(HGNC:PRKN) + + + + + + + + + pubmed:14556719 + + p(HGNC:SNCAIP) association p(HGNC:SNCA) + + + + + + + + + pubmed:14556719 + + composite(p(HGNC:SNCA), p(HGNC:SNCAIP)) increases a(MESH:"Inclusion Bodies") + + + + + + + + + pubmed:14556719 + + p(HGNC:CCNE1) association p(HGNC:PRKN) + + + + + + + pubmed:14556719 + + p(HGNC:CCNE1) positiveCorrelation bp(GO:"neuron apoptotic process") + + + + + + + pubmed:14556719 + + composite(a(PUBCHEM:164810), p(HGNC:PRKN)) decreases p(HGNC:CCNE1) + + + + + + + + + pubmed:14556719 + + p(HGNC:AIMP2) increases bp(GO:"cell death") + + + + + + + + + pubmed:14556719 + + p(HGNC:PRKN, var("p.Lys161Asn")) association path(MESH:"Parkinsonian Disorders") + + + + + + + pubmed:14556719 + + p(HGNC:PRKN, var("p.Lys161Asn")) increases p(HGNC:AIMP2, pmod(go:0016567 ! "protein ubiquitination")) + + + + + + + pubmed:14556719 + + p(HGNC:SYT11, pmod(go:0016567 ! "protein ubiquitination")) association bp(GO:"synaptic vesicle transport") + + + + + + + pubmed:14556719 + + p(HGNC:SYT11, pmod(go:0016567 ! "protein ubiquitination")) association tloc(a(CHEBI:neurotransmitter), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + + + pubmed:14556719 + + a(GO:"actin filament") association p(HGNC:PRKN) + + + + + + + + + + + pubmed:14556719 + + p(HGNC:UBE3A) increases complex(a(CONSO:"protein aggregates"), a(MESH:Neurons)) + + + + + + + pubmed:14556719 + + act(p(HGNC:UBE3A)) decreases bp(GO:"cell death") + + + + + + + pubmed:22908190 + + p(HGNC:UBE3A) increases deg(p(HGNC:ARC)) + + + + + + + pubmed:14556719 + + p(HGNC:UCHL1, var("p.Ile93Met")) association path(MESH:"Parkinson Disease") + + + + + + + pubmed:14556719 + + complex(p(HGNC:UCHL1), p(HGNC:UCHL1)) increases bp(GO:"protein K63-linked ubiquitination") + + + + + + + pubmed:22908190 + + p(HGNC:SNCA, pmod(go:0016567 ! "protein ubiquitination")) positiveCorrelation p(HGNC:SNCA) + + + + + + + pubmed:22908190 + + p(HGNC:SNCA, pmod(go:0016567 ! "protein ubiquitination")) positiveCorrelation path(MESH:"Parkinson Disease") + + + + + + + pubmed:22908190 + + p(HGNC:SNCA, pmod(go:0016567 ! "protein ubiquitination")) positiveCorrelation path(MESH:Dementia) + + + + + + + pubmed:14556719 + + p(HGNC:UCHL3) decreases path(MESH:"Deglutition Disorders") + + + + + + + pubmed:14556719 + + p(HGNC:UCHL3) positiveCorrelation a(MESH:"Solitary Nucleus") + + + + + + + pubmed:14556719 + + p(HGNC:UCHL3) positiveCorrelation a(MESH:"Area Postrema") + + + + + + + pubmed:14556719 + + a(MESH:"Solitary Nucleus") positiveCorrelation p(HGNC:UCHL1) + + + + + + + pubmed:14556719 + + a(MESH:"Solitary Nucleus") positiveCorrelation p(HGNC:UCHL3) + + + + + + + pubmed:14556719 + + a(MESH:"Area Postrema") positiveCorrelation p(HGNC:UCHL1) + + + + + + + pubmed:14556719 + + a(MESH:"Area Postrema") positiveCorrelation p(HGNC:UCHL3) + + + + + + + pubmed:14556719 + + bp(CONSO:"Alpha-synuclein Oligomerization") positiveCorrelation p(HGNC:SNCA) + + + + + + + pubmed:14556719 + + bp(CONSO:"Alpha-synuclein Oligomerization") increases a(CONSO:"alpha-synuclein fibrils") + + + + + + + pubmed:14556719 + + a(CONSO:"alpha-synuclein fibrils") increases a(CONSO:"alpha-synuclein aggregates") + + + + + + + pubmed:14556719 + + p(HGNC:SNCA, pmod(go:0006486 ! "protein glycosylation")) association p(HGNC:PRKN) + + + + + + + pubmed:14556719 + + complex(a(CONSO:"alpha-synuclein aggregates"), p(HGNC:PSMC4)) decreases act(complex(GO:"proteasome complex")) + + + + + + + + + + + + + pubmed:14556719 + + complex(p(HGNC:PSMC4), p(HGNC:SNCA)) decreases act(complex(GO:"proteasome complex")) + + + + + + + pubmed:14556719 + + p(HGNC:PARK7, pmod(go:0016925 ! "protein sumoylation")) regulates act(p(HGNC:PARK7)) + + + + + + + pubmed:14556719 + + complex(p(HGNC:PARK7), p(HGNC:PIAS2)) increases p(HGNC:PARK7, pmod(go:0016925 ! "protein sumoylation")) + + + + + + + + + pubmed:14556719 + + p(HGNC:PARK7, var("p.Leu166Pro")) association path(MESH:"Parkinsonian Disorders") + + + + + + + pubmed:14556719 + + p(HGNC:PARK7, var("p.Leu166Pro")) increases deg(p(HGNC:PARK7)) + + + + + + + pubmed:14556719 + + p(HGNC:PARK7, var("p.Leu166Pro")) increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + + + + + + + pubmed:14556719 + + p(HGNC:CFTR, var("p.Phe508del")) increases deg(p(HGNC:CFTR)) + + + + + + + pubmed:14556719 + + p(HGNC:CFTR, var("p.Phe508del")) increases path(MESH:"Cystic Fibrosis") + + + + + + + + + pubmed:14556719 + + deg(p(HGNC:CFTR)) increases path(MESH:"Cystic Fibrosis") + + + + + + + + + pubmed:30837838 + + p(HGNC:CFTR) association act(p(HGNC:TARDBP), ma(MESH:"RNA Splicing")) + + + + + + + pubmed:29311797 + + path(MESH:"Cystic Fibrosis") association p(HGNC:STUB1) + + + + + + + pubmed:29311797 + + path(MESH:"Cystic Fibrosis") association p(HGNC:AHSA1) + + + + + + + pubmed:14556719 + + p(HGNC:SEC61A1) increases tloc(p(MESH:Proteins, pmod(CONSO:misfolding)), fromLoc(GO:"endoplasmic reticulum lumen"), toLoc(GO:cytosol)) + + + + + + + + + + + + + + + + + pubmed:14556719 + + g(HGNC:MAPT, var("?")) increases path(MESH:"Pick Disease of the Brain") + + + + + + + + + pubmed:14556719 + + composite(a(CHEBI:amyloid-beta), p(HGNC:MAPT, var("?"))) increases path(MESH:"Alzheimer Disease") + + + + + + + pubmed:14556719 + + a(CHEBI:lactacystin) decreases act(complex(GO:"proteasome complex")) + + + + + + + pubmed:14556719 + + a(CHEBI:lactacystin) increases bp(GO:"cell death") + + + + + + + + + pubmed:22908190 + + a(CHEBI:lactacystin) decreases bp(GO:"long-term memory") + + + + + + + + + pubmed:30145931 + + a(CHEBI:lactacystin) decreases act(p(FPLX:Proteasome)) + + + + + + + pubmed:23528736 + + a(CHEBI:lactacystin) decreases act(p(FPLX:Proteasome)) + + + + + + + pubmed:24027553 + + a(CHEBI:lactacystin) decreases deg(p(HGNC:MAPT)) + + + + + + + pubmed:24027553 + + a(CHEBI:lactacystin) increases p(HGNC:MAPT) + + + + + + + pubmed:23528736 + + a(CHEBI:lactacystin) decreases deg(p(HGNC:MAPT)) + + + + + + + pubmed:24027553 + + a(CHEBI:lactacystin) decreases act(p(CONSO:"20 S Proteasome")) + + + + + + + pubmed:24027553 + + a(CHEBI:lactacystin) increases p(HGNC:MAPT, var("p.Pro301Leu")) + + + + + + + pubmed:24027553 + + a(CHEBI:lactacystin) decreases act(p(HGNCGENEFAMILY:Proteasome)) + + + + + + + pubmed:14556719 + + a(MESH:Prions) increases path(MESH:"Prion Diseases") + + + + + + + pubmed:14556719 + + a(MESH:Prions) increases path(MESH:"Encephalopathy, Bovine Spongiform") + + + + + + + + + pubmed:30837838 + + a(CHEBI:"copper(2+)") causesNoChange a(MESH:"Inclusion Bodies") + + + + + + + pubmed:30837838 + + a(CHEBI:"copper(2+)") causesNoChange path(MESH:"Protein Aggregation, Pathological") + + + + + + + pubmed:14556719 + + complex(p(HGNC:HSPA5), p(HGNC:PRNP)) increases bp(GO:"protein folding") + + + + + + + pubmed:14556719 + + p(HGNC:SOD1, pmod(CONSO:misfolding)) increases a(CONSO:"protein aggregates") + + + + + + + pubmed:14556719 + + p(HGNC:RNF19A) decreases bp(GO:"cell death") + + + + + + + pubmed:14556719 + + p(HGNC:RNF19A) increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + + + + + + + pubmed:14556719 + + p(HGNC:RNF19A) increases deg(p(HGNC:SOD1, var("?"))) + + + + + + + pubmed:14556719 + + p(HGNC:UBL5) positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:14556719 + + composite(a(CHEBI:lactacystin), p(HGNC:SOD1, var("?"))) increases bp(GO:"cell death") + + + + + + + pubmed:14556719 + + p(HGNC:CDC34, var("?")) decreases a(MESH:"Inclusion Bodies") + + + + + + + pubmed:14556719 + + p(HGNC:CDC34, var("?")) increases bp(GO:"cell death") + + + + + + + + + + + pubmed:24457024 + + p(HGNC:CDC34) increases complex(a(MESH:Ubiquitin), p(HGNC:CDC34)) + + + + + + + + + pubmed:14556719 + + p(HGNC:RAD23A) increases tloc(p(HGNC:ATXN3, pmod(go:0016567 ! "protein ubiquitination")), fromLoc(GO:cytosol), toLoc(GO:"proteasome complex")) + + + + + + + pubmed:14556719 + + composite(a(CHEBI:cystamine), p(HGNC:ATN1)) decreases a(CONSO:"protein aggregates") + + + + + + + pubmed:14556719 + + composite(a(CHEBI:cystamine), p(HGNC:ATN1)) decreases bp(GO:"cell death") + + + + + + + + + + + + + pubmed:14556719 + + composite(a(CHEBI:cystamine), p(HGNC:AR, var("?"))) decreases a(CONSO:"protein aggregates") + + + + + + + pubmed:14556719 + + composite(a(CHEBI:cystamine), p(HGNC:AR, var("?"))) decreases bp(GO:"cell death") + + + + + + + pubmed:14556719 + + a(CHEBI:"Congo Red") decreases a(CONSO:"huntingtin aggregates") + + + + + + + pubmed:14556719 + + a(CHEBI:"Congo Red") increases act(complex(GO:"proteasome complex")) + + + + + + + pubmed:22908190 + + p(FPLX:Caspase) increases deg(p(HGNC:MAPT)) + + + + + + + pubmed:29626319 + + p(FPLX:Caspase) increases deg(p(HGNC:MAPT)) + + + + + + + pubmed:25374103 + + p(FPLX:Caspase) increases path(MESH:Tauopathies) + + + + + + + pubmed:26631930 + + p(FPLX:Caspase) increases p(HGNC:MAPT, frag("26_230")) + + + + + + + pubmed:22908190 + + composite(a(MESH:Ubiquitin), p(HGNC:SQSTM1)) increases act(p(HGNC:VCP)) + + + + + + + pubmed:22908190 + + path(CONSO:"granulovacuolar degeneration") association a(MESH:Ubiquitin) + + + + + + + pubmed:22908190 + + path(CONSO:"granulovacuolar degeneration") association a(MESH:Ubiquitin) + + + + + + + pubmed:11943212 + + path(CONSO:"granulovacuolar degeneration") association complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)), p(HGNC:MARK4, pmod(go:0006468 ! "protein phosphorylation"))) + + + + + + + pubmed:11943212 + + path(CONSO:"granulovacuolar degeneration") positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:22908190 + + a(MESH:"Neuropil Threads") association a(MESH:Ubiquitin) + + + + + + + pubmed:26195256 + + a(MESH:"Neuropil Threads") association p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:22817713 + + a(MESH:"Neuropil Threads") association path(MESH:"Alzheimer Disease") + + + + + + + pubmed:23088643 + + a(MESH:"Neuropil Threads") association p(CONSO:"Tau epitope, AT8") + + + + + + + pubmed:22908190 + + bp(GO:"histone H2B ubiquitination") association bp(MESH:"Transcription, Genetic") + + + + + + + pubmed:22908190 + + bp(MESH:"Transcription, Genetic") association bp(GO:"histone H2B ubiquitination") + + + + + + + pubmed:22908190 + + p(CONSO:"Tau isoform F (441 aa)", pmod(go:0016567 ! "protein ubiquitination", Lys, 254)) association a(CONSO:"paired helical filaments") + + + + + + + pubmed:22908190 + + p(CONSO:"Tau isoform F (441 aa)", pmod(go:0016567 ! "protein ubiquitination", Lys, 257)) association a(CONSO:"paired helical filaments") + + + + + + + pubmed:22908190 + + p(CONSO:"Tau isoform F (441 aa)", pmod(go:0016567 ! "protein ubiquitination", Lys, 311)) association a(CONSO:"paired helical filaments") + + + + + + + pubmed:22908190 + + p(CONSO:"Tau isoform F (441 aa)", pmod(go:0016567 ! "protein ubiquitination", Lys, 317)) association a(CONSO:"paired helical filaments") + + + + + + + pubmed:22908190 + + p(CONSO:"Tau isoform F (441 aa)", pmod(go:0070936 ! "protein K48-linked ubiquitination")) association a(CONSO:"paired helical filaments") + + + + + + + pubmed:22908190 + + p(CONSO:"Tau isoform F (441 aa)", pmod(go:0070936 ! "protein K48-linked ubiquitination")) association a(CONSO:"paired helical filaments") + + + + + + + pubmed:22908190 + + p(CONSO:"Tau isoform F (441 aa)", pmod(go:0000209 ! "protein polyubiquitination", Lys, 6)) association a(CONSO:"paired helical filaments") + + + + + + + pubmed:22908190 + + p(CONSO:"Tau isoform F (441 aa)", pmod(go:0000209 ! "protein polyubiquitination", Lys, 11)) association a(CONSO:"paired helical filaments") + + + + + + + pubmed:22908190 + + a(GO:"Pick body") association p(HGNC:MAPT) + + + + + + + pubmed:27574109 + + a(GO:"Pick body") association p(HGNC:MAPT) + + + + + + + pubmed:22908190 + + a(GO:"Pick body") association a(MESH:Ubiquitin) + + + + + + + pubmed:27574109 + + a(GO:"Pick body") association a(CONSO:"Tau oligomers") + + + + + + + pubmed:27574109 + + a(GO:"Pick body") association p(CONSO:"phosphatase-activating domain") + + + + + + + pubmed:22908190 + + complex(a(MESH:Proteins), a(MESH:Ubiquitin), p(HGNC:UBA2), p(HGNC:UBA3)) increases p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination")) + + + + + + + pubmed:24457024 + + complex(a(MESH:Proteins), a(MESH:Ubiquitin), p(HGNC:UBA2), p(HGNC:UBA3)) increases bp(GO:"protein ubiquitination") + + + + + + + pubmed:22908190 + + p(HGNC:UBE4A) increases bp(GO:"protein polyubiquitination") + + + + + + + pubmed:22908190 + + complex(a(GO:"proteasome regulatory particle"), p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination"))) increases tloc(a(MESH:Proteins), fromLoc(GO:"proteasome regulatory particle"), toLoc(CONSO:"20 S Proteasome")) + + + + + + + + + + + + + pubmed:22908190 + + complex(a(GO:"proteasome regulatory particle"), p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) negativeCorrelation act(complex(GO:"proteasome complex")) + + + + + + + pubmed:22908190 + + complex(a(CONSO:"paired helical filaments"), a(GO:"proteasome regulatory particle")) decreases act(complex(GO:"proteasome complex")) + + + + + + + pubmed:22908190 + + p(CONSO:"Tau aggregates", pmod(CONSO:hyperphosphorylation)) increases p(CONSO:"Tau aggregates", pmod(CONSO:hyperphosphorylation), pmod(go:0016567 ! "protein ubiquitination")) + + + + + + + pubmed:22908190 + + p(CONSO:"UBB+1") positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:23528736 + + p(CONSO:"UBB+1") positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:22908190 + + p(CONSO:"UBB+1") positiveCorrelation path(MESH:"Niemann-Pick Diseases") + + + + + + + pubmed:22908190 + + p(CONSO:"UBB+1") positiveCorrelation path(MESH:"Huntington Disease") + + + + + + + + + pubmed:22908190 + + p(CONSO:"UBB+1") decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + + + + + + + pubmed:22908190 + + p(CONSO:"UBB+1") decreases bp(GO:memory) + + + + + + + pubmed:23528736 + + p(CONSO:"UBB+1") association a(MESH:"Neurofibrillary Tangles") + + + + + + + + + pubmed:22908190 + + p(CONSO:"UBB+1", pmod(go:0000209 ! "protein polyubiquitination")) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + + + + + + + pubmed:22908190 + + p(CONSO:"UBB+1", pmod(go:0000209 ! "protein polyubiquitination")) decreases deg(p(CONSO:"UBB+1", pmod(go:0000209 ! "protein polyubiquitination"))) + + + + + + + pubmed:22908190 + + p(CONSO:"UBB+1", pmod(go:0000209 ! "protein polyubiquitination")) increases path(CONSO:neurotoxicity) + + + + + + + pubmed:22908190 + + p(HGNC:UCHL1, pmod(GO:"protein oxidation")) negativeCorrelation a(GO:"neurofibrillary tangle") + + + + + + + pubmed:22908190 + + p(HGNC:UBQLN1, var("?")) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:22908190 + + deg(p(FPLX:PKA, pmod(go:0016567 ! "protein ubiquitination"))) increases act(p(FPLX:PKA)) + + + + + + + pubmed:22908190 + + a(CONSO:"AβOs") decreases act(a(GO:synapse)) + + + + + + + pubmed:22908190 + + a(CONSO:"AβOs") decreases bp(GO:"long-term synaptic potentiation") + + + + + + + pubmed:22908190 + + a(CONSO:"AβOs") decreases bp(GO:learning) + + + + + + + pubmed:22908190 + + a(CONSO:"AβOs") decreases bp(GO:memory) + + + + + + + pubmed:22908190 + + a(CONSO:"AβOs") increases bp(GO:"long-term synaptic depression") + + + + + + + pubmed:22908190 + + a(CONSO:"AβOs") decreases bp(GO:"L-glutamate import") + + + + + + + pubmed:22908190 + + a(CONSO:"AβOs") increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:22908190 + + a(CONSO:"AβOs") increases deg(a(MESH:Neurites)) + + + + + + + pubmed:22908190 + + a(CONSO:"AβOs") decreases act(complex(GO:"proteasome complex")) + + + + + + + pubmed:28528849 + + a(CONSO:"AβOs") decreases a(MESH:"Dendritic Spines") + + + + + + + pubmed:22908190 + + complex(p(HGNC:HSPA8), p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)), p(HGNC:STUB1)) increases deg(p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) + + + + + + + pubmed:22908190 + + complex(GO:"clathrin complex") increases bp(GO:"plasma membrane invagination") + + + + + + + pubmed:22908190 + + a(GO:caveola) increases bp(GO:"plasma membrane invagination") + + + + + + + pubmed:22908190 + + bp(GO:"bulk synaptic vesicle endocytosis") increases bp(GO:"plasma membrane invagination") + + + + + + + pubmed:29590627 + + bp(GO:"bulk synaptic vesicle endocytosis") negativeCorrelation a(CHEBI:"cytochalasin D") + + + + + + + pubmed:29590627 + + bp(GO:"bulk synaptic vesicle endocytosis") positiveCorrelation bp(GO:"actin filament polymerization") + + + + + + + pubmed:22908190 + + p(HGNC:RAB7A) increases a(GO:endosome) + + + + + + + pubmed:22908190 + + p(HGNC:RAB7A) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:22908190 + + p(HGNC:RAB7A) increases complex(a(GO:"early endosome"), a(GO:"late endosome")) + + + + + + + pubmed:22908190 + + p(HGNC:RAB7A) association bp(GO:"regulation of endosome size") + + + + + + + pubmed:18930136 + + p(HGNC:RAB7A) increases bp(GO:"autophagosome-lysosome fusion") + + + + + + + + + pubmed:29238289 + + p(HGNC:RAB7A) association tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:27181519 + + p(HGNC:RAB7A) association g(HGNC:C9orf72) + + + + + + + + + pubmed:22908190 + + act(a(GO:endosome)) increases bp(GO:"nerve growth factor signaling pathway") + + + + + + + pubmed:22908190 + + act(a(GO:endosome)) decreases path(CONSO:Neurodegeneration) + + + + + + + + + pubmed:22908190 + + complex(GO:"ESCRT complex") regulates tloc(a(MESH:Proteins), fromLoc(GO:cytoplasm), toLoc(GO:"multivesicular body")) + + + + + + + pubmed:22908190 + + p(HGNC:M6PR) increases tloc(a(MESH:Cathepsins), fromLoc(GO:"trans-Golgi network"), toLoc(GO:"multivesicular body")) + + + + + + + pubmed:22908190 + + a(MESH:Cathepsins) regulates deg(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:22908190 + + tloc(a(MESH:Cathepsins), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) increases bp(GO:"apoptotic process") + + + + + + + pubmed:22908190 + + p(HGNC:IGF2R) increases tloc(a(MESH:Cathepsins), fromLoc(GO:"trans-Golgi network"), toLoc(GO:"multivesicular body")) + + + + + + + pubmed:22908190 + + complex(a(GO:"late endosome"), a(GO:autophagosome), a(GO:lysosome)) increases deg(a(MESH:Proteins)) + + + + + + + + + + + + + pubmed:29024336 + + a(GO:"late endosome") increases deg(p(MGI:Mapt)) + + + + + + + pubmed:29024336 + + a(GO:"late endosome") decreases deg(p(MGI:Mapt, var("p.Pro301Leu"))) + + + + + + + pubmed:29024336 + + a(GO:"late endosome") decreases deg(p(MGI:Mapt, var("p.Ala152Thr"))) + + + + + + + pubmed:29590627 + + a(GO:"late endosome") association p(HGNC:MAPT, var("p.Pro301Ser")) + + + + + + + pubmed:29590627 + + a(GO:"late endosome") association a(CONSO:"Tau aggregates") + + + + + + + pubmed:22908190 + + complex(a(GO:"early endosome"), a(GO:autophagosome)) increases a(GO:amphisome) + + + + + + + + + + + pubmed:29590627 + + a(GO:"early endosome") association p(HGNC:MAPT, var("p.Pro301Ser")) + + + + + + + pubmed:29590627 + + a(GO:"early endosome") association a(CONSO:"Tau aggregates") + + + + + + + + + pubmed:18930136 + + a(GO:amphisome) increases complex(a(GO:amphisome), a(GO:lysosome)) + + + + + + + pubmed:22908190 + + complex(a(GO:"late endosome"), a(GO:autophagosome)) increases a(GO:amphisome) + + + + + + + pubmed:22908190 + + complex(a(GO:"multivesicular body"), a(GO:autophagosome)) increases a(GO:amphisome) + + + + + + + + + + + pubmed:22908190 + + bp(GO:"regulation of endosome size") association path(MESH:"Neurodegenerative Diseases") + + + + + + + pubmed:22908190 + + bp(GO:"regulation of endosome size") association a(CONSO:"Braak_Stage II") + + + + + + + pubmed:22908190 + + bp(GO:"regulation of endosome size") negativeCorrelation path(MESH:"Down Syndrome") + + + + + + + pubmed:22908190 + + bp(GO:"regulation of endosome size") association p(HGNC:RAB7A) + + + + + + + pubmed:22908190 + + bp(GO:"regulation of endosome size") association p(HGNC:RAB5A) + + + + + + + pubmed:22908190 + + bp(GO:"regulation of endosome size") association p(HGNC:RAB4A) + + + + + + + pubmed:22908190 + + a(CONSO:"Braak_Stage II") association bp(GO:"regulation of endosome size") + + + + + + + pubmed:27574109 + + a(CONSO:"Braak_Stage II") association a(CONSO:"Tau oligomers") + + + + + + + pubmed:27574109 + + a(CONSO:"Braak_Stage II") association p(CONSO:"phosphatase-activating domain") + + + + + + + pubmed:27574109 + + a(CONSO:"Braak_Stage II") association p(HGNC:MAPT) + + + + + + + pubmed:28176663 + + a(CONSO:"Braak_Stage II") positiveCorrelation act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:22908190 + + p(HGNC:RAB5A) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:22908190 + + p(HGNC:RAB5A) increases complex(a(GO:"early endosome"), a(GO:"late endosome")) + + + + + + + pubmed:22908190 + + p(HGNC:RAB5A) association bp(GO:"regulation of endosome size") + + + + + + + pubmed:22908190 + + act(p(HGNC:RAB5A)) positiveCorrelation a(MESH:Proteins) + + + + + + + pubmed:22908190 + + act(p(HGNC:RAB5A)) positiveCorrelation a(CHEBI:lipid) + + + + + + + pubmed:22908190 + + act(p(HGNC:RAB5A)) negativeCorrelation bp(GO:"lysosomal protein catabolic process") + + + + + + + pubmed:22908190 + + act(p(HGNC:RAB5A)) positiveCorrelation bp(GO:"neuron death") + + + + + + + pubmed:22908190 + + act(p(HGNC:RAB5A)) increases bp(GO:endocytosis) + + + + + + + pubmed:22908190 + + act(p(HGNC:RAB5A)) increases bp(GO:endocytosis) + + + + + + + pubmed:22908190 + + act(p(HGNC:RAB5A)) decreases bp(GO:endocytosis) + + + + + + + pubmed:22908190 + + act(p(HGNC:RAB5A)) increases a(CHEBI:amyloid-beta) + + + + + + + pubmed:22908190 + + act(p(HGNC:RAB5A)) negativeCorrelation bp(GO:"long-term synaptic potentiation") + + + + + + + pubmed:22908190 + + act(p(HGNC:RAB5A)) negativeCorrelation bp(GO:"long-term synaptic depression") + + + + + + + pubmed:30116051 + + act(p(HGNC:RAB5A)) decreases bp(HP:Neurodegeneration) + + + + + + + pubmed:27607061 + + act(p(HGNC:RAB5A)) negativeCorrelation tloc(p(HGNC:GRIK2), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) + + + + + + + pubmed:27607061 + + act(p(HGNC:RAB5A)) partOf bp(GO:"clathrin-dependent endocytosis") + + + + + + + pubmed:27181519 + + p(HGNC:RAB5A) association g(HGNC:C9orf72) + + + + + + + pubmed:22908190 + + p(HGNC:RAB4A) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:22908190 + + p(HGNC:RAB4A) increases complex(a(GO:"early endosome"), a(GO:"late endosome")) + + + + + + + pubmed:22908190 + + p(HGNC:RAB4A) association bp(GO:"regulation of endosome size") + + + + + + + pubmed:22908190 + + bp(GO:"pH reduction") increases bp(GO:"lysosomal protein catabolic process") + + + + + + + pubmed:22908190 + + p(HGNC:ATP6V0A1, pmod(go:0006487 ! "protein N-linked glycosylation")) increases bp(GO:"pH reduction") + + + + + + + + + + + pubmed:22908190 + + complex(a(GO:endosome), p(HGNC:APP, var("?")), p(HGNC:NAE1, var("?"))) increases act(p(HGNC:RAB5A)) + + + + + + + + + pubmed:22908190 + + a(CHEBI:"low-density lipoprotein cholesterol") positiveCorrelation p(CONSO:"APP C-terminally truncated carboxyl-terminal fragments") + + + + + + + pubmed:22908190 + + a(CHEBI:"low-density lipoprotein cholesterol") positiveCorrelation p(CONSO:"APP C-terminally truncated carboxyl-terminal fragments") + + + + + + + pubmed:22908190 + + a(CHEBI:"low-density lipoprotein cholesterol") positiveCorrelation tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:cytosol), toLoc(GO:lysosome)) + + + + + + + pubmed:22908190 + + bp(GO:"response to acidic pH") increases a(CONSO:"amyloid-beta oligomers") + + + + + + + pubmed:22908190 + + p(HGNC:RIN1) increases act(p(HGNC:RAB5A)) + + + + + + + pubmed:22908190 + + p(HGNC:RIN1) decreases bp(GO:"long-term synaptic potentiation") + + + + + + + pubmed:22908190 + + p(HGNC:RIN1) decreases bp(GO:"fear response") + + + + + + + pubmed:22908190 + + p(HGNC:RIN1) decreases bp(GO:memory) + + + + + + + pubmed:22908190 + + p(HGNC:RIN1) decreases a(MESH:"Receptors, AMPA") + + + + + + + pubmed:22908190 + + tloc(a(MESH:Hydrolases), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) increases path(MESH:Necrosis) + + + + + + + pubmed:22908190 + + p(HGNC:CST3) decreases act(a(GO:synapse)) + + + + + + + pubmed:24563850 + + a(MESH:"Heat-Shock Proteins") regulates bp(GO:"response to oxidative stress") + + + + + + + pubmed:21882945 + + a(MESH:"Heat-Shock Proteins") increases bp(GO:"proteasomal protein catabolic process") + + + + + + + pubmed:21882945 + + a(MESH:"Heat-Shock Proteins") increases bp(GO:autophagy) + + + + + + + pubmed:23746257 + + act(p(HGNCGENEFAMILY:Chaperonins)) association bp(GO:"'de novo' protein folding") + + + + + + + pubmed:23746257 + + act(p(HGNCGENEFAMILY:Chaperonins)) association bp(GO:"protein refolding") + + + + + + + pubmed:23746257 + + bp(GO:"protein refolding") association act(p(HGNCGENEFAMILY:Chaperonins)) + + + + + + + pubmed:23746257 + + bp(GO:"protein refolding") association act(p(FPLX:HSPA)) + + + + + + + pubmed:23746257 + + bp(GO:"protein refolding") association act(p(FPLX:HSPA)) + + + + + + + pubmed:23746257 + + bp(GO:"protein refolding") association act(p(FPLX:HSP90)) + + + + + + + pubmed:23746257 + + complex(p(FPLX:"CCT_complex"), p(FPLX:HSPA)) increases bp(GO:"'de novo' protein folding") + + + + + + + pubmed:23746257 + + bp(GO:"steroid hormone mediated signaling pathway") association p(FPLX:HSP90) + + + + + + + pubmed:23746257 + + bp(GO:"intracellular protein transmembrane transport") association act(p(FPLX:HSPA)) + + + + + + + pubmed:23746257 + + p(FPLX:RAPGEF) regulates act(p(FPLX:HSPA)) + + + + + + + pubmed:23746257 + + composite(p(FPLX:HSPA), p(HGNC:HSPH1), p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins")) decreases a(MESH:"Protein Aggregates") + + + + + + + + + + + pubmed:21882945 + + p(HGNC:HSPH1) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:23746257 + + complex(p(HGNC:HSPD1), p(HGNC:HSPE1)) increases bp(GO:"protein refolding") + + + + + + + + + pubmed:23746257 + + complex(a(CHEBI:ATP), p(HGNC:HSPD1)) increases complex(p(HGNC:HSPD1), p(HGNC:HSPE1)) + + + + + + + pubmed:23746257 + + a(PUBCHEM:5288382) decreases complex(a(CHEBI:ATP), p(FPLX:HSP90)) + + + + + + + pubmed:23746257 + + complex(a(CHEBI:ATP), p(FPLX:HSP90)) regulates act(p(FPLX:HSP90)) + + + + + + + pubmed:29311797 + + complex(a(CHEBI:ATP), p(FPLX:HSP90)) increases bp(MESH:Proteolysis) + + + + + + + pubmed:29311797 + + complex(a(CHEBI:ATP), p(FPLX:HSP90)) increases bp(GO:"protein folding") + + + + + + + pubmed:29311797 + + complex(a(CHEBI:ATP), p(FPLX:HSP90)) decreases path(MESH:"Protein Aggregation, Pathological") + + + + + + + pubmed:29311797 + + complex(a(CHEBI:ATP), p(FPLX:HSP90)) increases bp(GO:"protein modification process") + + + + + + + pubmed:23746257 + + a(PUBCHEM:6323491) decreases complex(a(CHEBI:ATP), p(FPLX:HSP90)) + + + + + + + pubmed:23746257 + + bp(GO:"ATP metabolic process") increases act(p(FPLX:HSP90)) + + + + + + + pubmed:25784053 + + bp(GO:"ATP metabolic process") increases act(p(FPLX:HSP90)) + + + + + + + pubmed:29311797 + + bp(GO:"ATP metabolic process") increases act(p(FPLX:HSP90)) + + + + + + + pubmed:25784053 + + bp(GO:"ATP metabolic process") increases act(p(FPLX:HSPA)) + + + + + + + pubmed:23746257 + + p(HGNC:AHSA1) increases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) + + + + + + + pubmed:21882945 + + p(HGNC:AHSA1) regulates act(p(FPLX:HSP90), ma(GO:"ATPase activity")) + + + + + + + pubmed:29311797 + + p(HGNC:AHSA1) increases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) + + + + + + + + + pubmed:21882945 + + p(HGNC:AHSA1) increases rxn(reactants(a(CHEBI:ATP)), products(a(CHEBI:"phosphate(3-)"), a(CHEBI:ADP))) + + + + + + + pubmed:21882945 + + p(HGNC:AHSA1) increases complex(a(CHEBI:polypeptide), p(HGNC:STUB1)) + + + + + + + pubmed:29311797 + + p(HGNC:AHSA1) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:29311797 + + p(HGNC:AHSA1) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:29311797 + + p(HGNC:AHSA1) association path(MESH:"Cystic Fibrosis") + + + + + + + + + pubmed:23746257 + + bp(GO:"behavioral response to starvation") association bp(CONSO:Proteostasis) + + + + + + + pubmed:23746257 + + composite(p(FPLX:HSP90), p(FPLX:HSPA), p(HGNC:BAG1), p(HGNC:BAG3), p(HGNC:STUB1)) increases bp(GO:"protein ubiquitination") + + + + + + + + + pubmed:23746257 + + p(HGNC:BAG1) increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + + + + + + + + + pubmed:25036637 + + p(HGNC:BAG1) increases complex(p(HGNC:BAG1), p(HGNC:LTN1)) + + + + + + + + + + + pubmed:25036637 + + p(HGNC:BAG1) directlyIncreases complex(p(HGNC:BAG1), p(HGNC:PSMA5)) + + + + + + + + + pubmed:25036637 + + p(HGNC:BAG1) directlyIncreases complex(p(HGNC:BAG1), p(HGNC:PSMC4)) + + + + + + + + + pubmed:25036637 + + p(HGNC:BAG1) directlyIncreases complex(p(HGNC:BAG1), p(HGNC:PSMD2)) + + + + + + + pubmed:21882945 + + p(HGNC:BAG1) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + + + pubmed:21882945 + + p(HGNC:BAG1) directlyIncreases complex(p(HGNC:BAG1), p(HGNC:MAPT)) + + + + + + + + + pubmed:21882945 + + p(HGNC:BAG1) decreases deg(p(HGNC:MAPT)) + + + + + + + pubmed:17954934 + + p(HGNC:BAG1) increases p(HGNC:MAPT) + + + + + + + pubmed:17954934 + + p(HGNC:BAG1) decreases deg(p(HGNC:MAPT)) + + + + + + + pubmed:17954934 + + p(HGNC:BAG1) positiveCorrelation p(HGNC:MAPT) + + + + + + + pubmed:17954934 + + p(HGNC:BAG1) decreases deg(p(HGNC:MAPT)) + + + + + + + + + pubmed:17954934 + + p(HGNC:BAG1) isA complex(p(HGNC:BAG1), p(HGNC:HSPA8), p(HGNC:MAPT)) + + + + + + + pubmed:17954934 + + p(HGNC:BAG1) association act(a(MESH:Neurons)) + + + + + + + pubmed:17954934 + + p(HGNC:BAG1) negativeCorrelation act(complex(GO:"proteasome complex")) + + + + + + + pubmed:17954934 + + p(HGNC:BAG1) negativeCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:17954934 + + p(HGNC:BAG1) causesNoChange p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) + + + + + + + + + pubmed:23746257 + + p(FPLX:EIF2B, pmod(go:0006468 ! "protein phosphorylation")) decreases act(p(FPLX:EIF2B)) + + + + + + + pubmed:23746257 + + a(CHEBI:geldanamycin) increases act(p(HGNC:HSF1)) + + + + + + + pubmed:25784053 + + a(CHEBI:geldanamycin) decreases act(p(FPLX:HSP90)) + + + + + + + pubmed:30116051 + + a(CHEBI:geldanamycin) decreases act(p(FPLX:HSP90)) + + + + + + + pubmed:21882945 + + a(CHEBI:geldanamycin) decreases act(p(FPLX:HSP90)) + + + + + + + pubmed:21882945 + + a(CHEBI:geldanamycin) decreases act(p(FPLX:HSP90)) + + + + + + + pubmed:30116051 + + a(CHEBI:geldanamycin) decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:30116051 + + a(CHEBI:geldanamycin) decreases a(CONSO:"alpha-synuclein oligomers") + + + + + + + pubmed:24027553 + + a(CHEBI:geldanamycin) increases act(p(HGNCGENEFAMILY:Proteasome)) + + + + + + + pubmed:21882945 + + a(CHEBI:geldanamycin) decreases complex(p(FPLX:HSP90), p(HGNC:PTGES3)) + + + + + + + pubmed:23746257 + + composite(p(FPLX:"CCT_complex"), p(FPLX:HSPA)) decreases a(MESH:"Protein Aggregates") + + + + + + + pubmed:23746257 + + composite(p(FPLX:"CCT_complex"), p(FPLX:HSPA)) decreases a(CONSO:"huntingtin aggregates") + + + + + + + pubmed:24457024 + + complex(a(CHEBI:ATP), p(HGNC:UBA1)) increases act(a(MESH:Ubiquitin)) + + + + + + + pubmed:24457024 + + complex(a(CHEBI:ATP), p(HGNC:UBA1)) increases act(a(MESH:Ubiquitin)) + + + + + + + + + pubmed:24457024 + + p(HGNC:UBE2K) increases complex(a(MESH:Ubiquitin), p(HGNC:UBE2K)) + + + + + + + + + pubmed:24457024 + + p(HGNC:UBE2S) increases complex(a(MESH:Ubiquitin), p(HGNC:UBE2S)) + + + + + + + pubmed:24457024 + + path(MESH:"RING Finger Domains") increases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) + + + + + + + pubmed:24457024 + + p(INTERPRO:"U box domain") increases complex(a(MESH:Ubiquitin), p(HGNC:UBA2)) + + + + + + + + + pubmed:24457024 + + complex(a(MESH:Ubiquitin), p(MESH:Proteins, pmod(CONSO:misfolding))) increases deg(p(MESH:Proteins, pmod(CONSO:misfolding))) + + + + + + + + + pubmed:24457024 + + p(HGNC:BAG6) increases complex(p(HGNC:BAG6), p(MESH:Proteins, pmod(CONSO:misfolding))) + + + + + + + + + + + pubmed:24457024 + + complex(p(HGNC:BAG6), p(MESH:Proteins, pmod(CONSO:misfolding))) association bp(GO:"ERAD pathway") + + + + + + + pubmed:24457024 + + complex(p(HGNC:BAG6), p(HGNC:UBA3)) increases deg(p(MESH:Proteins, pmod(CONSO:misfolding))) + + + + + + + pubmed:24457024 + + complex(p(HGNC:BAG6), p(HGNC:UBA3)) increases bp(GO:"protein ubiquitination") + + + + + + + pubmed:24457024 + + complex(p(HGNC:BAG6), p(HGNC:UBA3)) decreases bp(CONSO:"protein aggregation") + + + + + + + pubmed:24457024 + + complex(a(GO:"proteasome complex"), p(HGNC:BAG6)) increases deg(p(MESH:Proteins, pmod(CONSO:misfolding))) + + + + + + + pubmed:24457024 + + complex(a(GO:"proteasome complex"), p(HGNC:BAG6)) decreases bp(CONSO:"protein aggregation") + + + + + + + pubmed:24457024 + + complex(a(GO:"proteasome complex"), p(HGNC:BAG6)) increases bp(GO:"protein ubiquitination") + + + + + + + pubmed:24457024 + + a(MESH:"Deubiquitinating Enzymes") decreases complex(a(MESH:Proteins), a(MESH:Ubiquitin)) + + + + + + + pubmed:24457024 + + a(MESH:"Deubiquitinating Enzymes") increases p(MESH:Ubiquitin, frag("?")) + + + + + + + + + pubmed:26091809 + + p(MESH:Ubiquitin, loc(GO:"inclusion body")) increases p(HGNC:TARDBP) + + + + + + + pubmed:24457024 + + complex(a(GO:"proteasome complex"), p(HGNC:UCHL5)) increases bp(GO:"protein catabolic process") + + + + + + + + + pubmed:24457024 + + complex(a(GO:"proteasome complex"), p(HGNC:USP14)) increases bp(GO:"protein catabolic process") + + + + + + + pubmed:24457024 + + complex(a(GO:"proteasome complex"), p(HGNC:USP14)) decreases bp(GO:"protein catabolic process") + + + + + + + pubmed:24457024 + + act(p(HGNC:USP6)) decreases path(MESH:Aneuploidy) + + + + + + + pubmed:24457024 + + p(HGNC:ADRM1) increases complex(a(GO:"proteasome complex"), p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination"))) + + + + + + + + + + + pubmed:25036637 + + p(HGNC:ADRM1) directlyIncreases complex(p(HGNC:ADRM1), p(HGNC:PSMA5)) + + + + + + + + + pubmed:25036637 + + p(HGNC:ADRM1) directlyIncreases complex(p(HGNC:ADRM1), p(HGNC:PSMC1)) + + + + + + + + + pubmed:25036637 + + p(HGNC:ADRM1) directlyIncreases complex(p(HGNC:ADRM1), p(HGNC:PSMD1)) + + + + + + + + + pubmed:25036637 + + p(HGNC:ADRM1) directlyIncreases complex(p(HGNC:ADRM1), p(HGNC:PSMD4)) + + + + + + + pubmed:24457024 + + p(HGNC:PSMD14) decreases complex(a(MESH:Proteins), a(MESH:Ubiquitin)) + + + + + + + pubmed:24457024 + + p(HGNC:PSMD14) decreases complex(a(MESH:Proteins), a(MESH:Ubiquitin)) + + + + + + + pubmed:24457024 + + act(p(HGNC:PSMD14)) increases tloc(a(MESH:Proteins), fromLoc(GO:cytosol), toLoc(CONSO:"20 S Proteasome")) + + + + + + + pubmed:24457024 + + complex(a(GO:"proteasome complex"), a(MESH:Proteins)) increases tloc(a(MESH:Proteins), fromLoc(GO:cytosol), toLoc(CONSO:"20 S Proteasome")) + + + + + + + pubmed:25784053 + + bp(MESH:"Protein Biosynthesis") association bp(CONSO:Proteostasis) + + + + + + + pubmed:25784053 + + bp(MESH:Proteolysis) association bp(CONSO:Proteostasis) + + + + + + + pubmed:29311797 + + bp(MESH:Proteolysis) association a(MESH:"Molecular Chaperones") + + + + + + + pubmed:25784053 + + bp(MESH:"Growth and Development") regulates bp(CONSO:Proteostasis) + + + + + + + pubmed:25784053 + + complex(p(FPLX:HSPA), p(HGNC:DNAJB1), p(HGNC:HSPH1)) decreases path(MESH:"Protein Aggregation, Pathological") + + + + + + + + + pubmed:25784053 + + p(HGNC:DNAJB1) negativeCorrelation path(MESH:"Protein Aggregation, Pathological") + + + + + + + + + pubmed:25036637 + + p(HGNC:DNAJB1) increases complex(p(HGNC:DNAJB1), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) + + + + + + + pubmed:25784053 + + a(MESH:"Cellular Structures") association p(FPLX:"CCT_complex") + + + + + + + pubmed:25784053 + + bp(GO:"response to misfolded protein") increases act(p(HGNC:HSF1)) + + + + + + + pubmed:25784053 + + bp(GO:"response to misfolded protein") increases act(p(HGNC:ERN1), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:25784053 + + p(HGNC:HSF1, pmod(go:0006473 ! "protein acetylation")) decreases act(p(HGNC:HSF1)) + + + + + + + pubmed:25784053 + + complex(a(MESH:"Molecular Chaperones"), p(HGNC:HSF1)) decreases act(p(HGNC:HSF1)) + + + + + + + pubmed:25784053 + + p(HGNC:PRSS1) decreases p(HGNC:ATF6) + + + + + + + pubmed:25784053 + + p(HGNC:PRSS1) increases p(CONSO:"N-terminal fragment of ATF6") + + + + + + + pubmed:25784053 + + p(HGNC:PRSS2) decreases p(HGNC:ATF6) + + + + + + + pubmed:25784053 + + p(HGNC:PRSS2) increases p(CONSO:"N-terminal fragment of ATF6") + + + + + + + pubmed:25784053 + + tloc(p(CONSO:"N-terminal fragment of ATF6"), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus")) increases act(p(CONSO:"N-terminal fragment of ATF6"), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) + + + + + + + pubmed:25784053 + + act(p(CONSO:"N-terminal fragment of ATF6"), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) increases bp(GO:"response to misfolded protein") + + + + + + + pubmed:25784053 + + p(HGNC:ATXN1, var("?")) causesNoChange p(FPLX:HSPA) + + + + + + + + + pubmed:25784053 + + p(HGNC:SOD1, var("p.Gly576Arg")) decreases a(CHEBI:N-retinylidene-N-retinylethanolamine) + + + + + + + pubmed:25784053 + + p(HGNC:SOD1, var("p.Gly576Arg")) decreases p(HGNC:MAP1LC3A) + + + + + + + pubmed:25784053 + + p(HGNC:SOD1, var("p.Gly576Arg")) decreases p(HGNC:SQSTM1) + + + + + + + pubmed:25784053 + + p(HGNC:SOD1, var("p.Gly576Arg")) increases bp(GO:autophagy) + + + + + + + pubmed:25784053 + + a(CHEBI:radicicol) decreases act(p(FPLX:HSP90)) + + + + + + + pubmed:21882945 + + a(CHEBI:radicicol) directlyDecreases act(p(FPLX:HSP90)) + + + + + + + + + pubmed:21882945 + + a(CHEBI:radicicol) directlyIncreases complex(a(CHEBI:radicicol), p(INTERPRO:"Heat shock protein Hsp90, N-terminal")) + + + + + + + pubmed:21882945 + + a(CHEBI:radicicol) decreases path(MESH:Neoplasms) + + + + + + + pubmed:25784053 + + a(CHEBI:tanespimycin) decreases act(p(FPLX:HSP90)) + + + + + + + pubmed:30116051 + + a(CHEBI:tanespimycin) decreases act(p(FPLX:HSP90)) + + + + + + + pubmed:21882945 + + a(CHEBI:tanespimycin) decreases act(p(FPLX:HSP90)) + + + + + + + pubmed:29311797 + + a(CHEBI:tanespimycin) decreases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) + + + + + + + pubmed:21367866 + + a(CHEBI:tanespimycin) decreases act(p(FPLX:HSP90)) + + + + + + + pubmed:30116051 + + a(CHEBI:tanespimycin) decreases a(CHEBI:amyloid-beta) + + + + + + + pubmed:30116051 + + a(CHEBI:tanespimycin) increases bp(GO:memory) + + + + + + + pubmed:30116051 + + a(CHEBI:tanespimycin) decreases p(HGNC:MAPT) + + + + + + + pubmed:30116051 + + a(CHEBI:tanespimycin) decreases a(CONSO:"alpha-synuclein oligomers") + + + + + + + pubmed:21882945 + + a(CHEBI:tanespimycin) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) + + + + + + + pubmed:21882945 + + a(CHEBI:tanespimycin) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396), pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + + + + + + + pubmed:29311797 + + a(CHEBI:tanespimycin) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:25784053 + + a(PUBCHEM:377503130) increases act(p(HGNC:HSF1)) + + + + + + + pubmed:25784053 + + a(PUBCHEM:377503130) decreases act(p(FPLX:"CCT_complex")) + + + + + + + pubmed:25784053 + + a(PUBCHEM:10521421) decreases act(p(FPLX:AKT)) + + + + + + + pubmed:25784053 + + a(PUBCHEM:10521421) increases bp(GO:autophagy) + + + + + + + pubmed:25784053 + + a(CHEBI:fluphenazine) increases bp(GO:autophagy) + + + + + + + pubmed:25784053 + + a(CHEBI:fluphenazine) decreases p(HGNC:TARDBP) + + + + + + + pubmed:25784053 + + a(CHEBI:methotrimeprazine) increases bp(GO:autophagy) + + + + + + + pubmed:25784053 + + a(CHEBI:methotrimeprazine) decreases p(HGNC:TARDBP) + + + + + + + pubmed:25784053 + + a(PUBCHEM:799645) increases bp(GO:autophagy) + + + + + + + pubmed:25784053 + + a(PUBCHEM:799645) decreases p(HGNC:SNCA, var("p.Ala53Thr")) + + + + + + + + + pubmed:25784053 + + a(PUBCHEM:799645) decreases a(CONSO:"huntingtin aggregates") + + + + + + + pubmed:25784053 + + a(PUBCHEM:877863) increases bp(GO:autophagy) + + + + + + + pubmed:25784053 + + a(PUBCHEM:877863) decreases p(HGNC:SNCA, var("p.Ala53Thr")) + + + + + + + + + pubmed:25784053 + + a(PUBCHEM:877863) decreases a(CONSO:"huntingtin aggregates") + + + + + + + pubmed:25784053 + + a(PUBCHEM:1560402) increases bp(GO:autophagy) + + + + + + + pubmed:25784053 + + a(PUBCHEM:1560402) decreases p(HGNC:SNCA, var("p.Ala53Thr")) + + + + + + + + + pubmed:25784053 + + a(PUBCHEM:1560402) decreases a(CONSO:"huntingtin aggregates") + + + + + + + pubmed:25784053 + + composite(a(CHEBI:sirolimus), a(PUBCHEM:799645)) decreases p(HGNC:SNCA, var("p.Ala53Thr")) + + + + + + + pubmed:25784053 + + composite(a(CHEBI:sirolimus), a(PUBCHEM:877863)) decreases p(HGNC:SNCA, var("p.Ala53Thr")) + + + + + + + pubmed:25784053 + + composite(a(CHEBI:sirolimus), a(PUBCHEM:1560402)) decreases p(HGNC:SNCA, var("p.Ala53Thr")) + + + + + + + pubmed:25784053 + + a(PUBCHEM:675434) decreases p(HGNC:MAPT) + + + + + + + pubmed:23528736 + + a(PUBCHEM:675434) increases deg(p(HGNC:MAPT)) + + + + + + + pubmed:25784053 + + a(PUBCHEM:675434) decreases p(HGNC:TARDBP) + + + + + + + pubmed:25784053 + + a(PUBCHEM:675434) decreases p(HGNC:ATXN3) + + + + + + + pubmed:25784053 + + a(PUBCHEM:675434) decreases act(p(HGNC:USP14)) + + + + + + + pubmed:23528736 + + a(PUBCHEM:675434) decreases act(p(HGNC:USP14)) + + + + + + + pubmed:25784053 + + a(PUBCHEM:675434) causesNoChange p(FPLX:Proteasome) + + + + + + + pubmed:23528736 + + a(PUBCHEM:675434) increases act(p(FPLX:Proteasome)) + + + + + + + + + + + pubmed:18930136 + + deg(a(CHEBI:oligopeptide)) increases a(CHEBI:"amino acid") + + + + + + + pubmed:26702100 + + a(CHEBI:"amino acid") regulates act(p(HGNCGENEFAMILY:"MTOR complex 1")) + + + + + + + pubmed:26702100 + + a(CHEBI:"amino acid") increases p(HGNC:MTOR) + + + + + + + pubmed:26702100 + + a(CHEBI:"amino acid") increases p(HGNC:MTOR) + + + + + + + pubmed:26702100 + + a(CHEBI:"amino acid") increases p(HGNC:RPS6KB1, pmod(go:0006468 ! "protein phosphorylation", Thr, 389)) + + + + + + + pubmed:26702100 + + a(CHEBI:"amino acid") increases act(p(HGNC:RRAGA)) + + + + + + + pubmed:18930136 + + bp(GO:"antigen processing and presentation") association bp(GO:autophagy) + + + + + + + pubmed:18930136 + + bp(GO:"autophagy of nucleus") isA bp(GO:macroautophagy) + + + + + + + pubmed:18930136 + + bp(GO:pexophagy) isA bp(GO:macroautophagy) + + + + + + + pubmed:18930136 + + bp(GO:reticulophagy) isA bp(GO:macroautophagy) + + + + + + + pubmed:18930136 + + bp(GO:xenophagy) isA bp(GO:macroautophagy) + + + + + + + pubmed:18930136 + + bp(GO:ribophagy) isA bp(GO:macroautophagy) + + + + + + + pubmed:18930136 + + bp(GO:aggrephagy) isA bp(GO:macroautophagy) + + + + + + + pubmed:18930136 + + complex(a(MESH:Proteins), p(HGNC:HSPA8)) increases bp(GO:"chaperone-mediated autophagy") + + + + + + + pubmed:18930136 + + complex(a(MESH:Proteins), p(HGNC:HSPA8)) increases complex(a(MESH:Proteins), p(HGNC:HSPA8), p(HGNC:LAMP2)) + + + + + + + pubmed:18930136 + + composite(p(HGNC:ATG10), p(HGNC:ATG7)) increases complex(p(HGNC:ATG12), p(HGNC:ATG5)) + + + + + + + pubmed:18930136 + + composite(p(HGNC:ATG10), p(HGNC:ATG7)) increases a(GO:phagophore) + + + + + + + + + pubmed:18930136 + + complex(p(HGNC:ATG12), p(HGNC:ATG5)) increases complex(p(HGNC:ATG12), p(HGNC:ATG16L1), p(HGNC:ATG5)) + + + + + + + pubmed:18930136 + + complex(p(HGNC:ATG12), p(HGNC:ATG5)) increases p(HGNC:GABARAPL2, pmod(GO:"protein lipidation")) + + + + + + + pubmed:18930136 + + complex(p(HGNC:ATG12), p(HGNC:ATG16L1), p(HGNC:ATG5)) increases a(GO:phagophore) + + + + + + + + + pubmed:18930136 + + p(HGNC:ATG4A) increases p(HGNC:GABARAPL2, frag("?")) + + + + + + + + + pubmed:18930136 + + p(HGNC:ATG4A) increases complex(p(HGNC:ATG4A), p(HGNC:ATG7)) + + + + + + + + + pubmed:18930136 + + composite(p(HGNC:ATG12), p(HGNC:ATG3), p(HGNC:ATG5)) increases complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:GABARAPL2, frag("?"))) + + + + + + + + + + + + + + + + + pubmed:18930136 + + complex(a(GO:"multivesicular body"), a(GO:autophagosome), a(GO:endosome)) increases a(GO:amphisome) + + + + + + + pubmed:18930136 + + complex(a(GO:amphisome), a(GO:lysosome)) increases a(GO:autolysosome) + + + + + + + + + pubmed:18930136 + + p(HGNC:GABARAP) increases complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:GABARAP)) + + + + + + + pubmed:18930136 + + complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:MAP1LC3B)) increases complex(a(CHEBI:phosphatidylethanolamine), a(GO:phagophore), p(HGNC:MAP1LC3B)) + + + + + + + pubmed:18930136 + + complex(a(CHEBI:phosphatidylethanolamine), p(HGNC:MAP1LC3B)) association a(GO:autophagosome) + + + + + + + pubmed:18930136 + + path(MESH:"Creutzfeldt-Jakob Syndrome") positiveCorrelation a(GO:autophagosome) + + + + + + + pubmed:18930136 + + path(MESH:"Neuronal Ceroid-Lipofuscinoses") negativeCorrelation act(a(GO:lysosome)) + + + + + + + pubmed:18930136 + + p(HGNC:CLN3, var("?")) increases path(MESH:"Neuronal Ceroid-Lipofuscinoses") + + + + + + + + + pubmed:18930136 + + p(HGNC:ATP13A2, var("?")) increases bp(GO:"proteasomal protein catabolic process") + + + + + + + pubmed:18930136 + + p(HGNC:ATP13A2, var("?")) increases path(CONSO:Neurodegeneration) + + + + + + + + + pubmed:18930136 + + p(HGNC:RAB7A, var("?")) decreases bp(GO:"autophagosome-lysosome fusion") + + + + + + + pubmed:18930136 + + p(HGNC:DCTN1, var("?")) positiveCorrelation a(GO:autophagosome) + + + + + + + + + + + pubmed:8391280 + + p(HGNC:DCTN1) isA complex(p(HGNC:DCTN1), p(HGNC:MAPT)) + + + + + + + + + pubmed:8391280 + + p(HGNC:DCTN1) association p(INTERPRO:"MAP2/Tau projection") + + + + + + + pubmed:8391280 + + p(HGNC:DCTN1) isA p(INTERPRO:"Dynein associated protein") + + + + + + + pubmed:26702100 + + p(HGNC:DCTN1) increases bp(GO:"autophagosome-lysosome fusion") + + + + + + + pubmed:26702100 + + p(HGNC:DCTN1) increases bp(GO:"autophagosome-lysosome fusion") + + + + + + + pubmed:18930136 + + bp(GO:"protein monoubiquitination") increases bp(GO:endocytosis) + + + + + + + pubmed:18930136 + + a(GO:aggresome) negativeCorrelation bp(GO:"cell death") + + + + + + + pubmed:18930136 + + composite(a(CHEBI:lactacystin), a(CHEBI:sirolimus)) decreases bp(GO:"apoptotic process") + + + + + + + pubmed:18930136 + + composite(a(CHEBI:lactacystin), a(CHEBI:sirolimus)) decreases p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination")) + + + + + + + pubmed:18930136 + + p(HGNC:WDFY3) regulates bp(GO:autophagy) + + + + + + + pubmed:18930136 + + p(HGNC:WDFY3) regulates bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + + + + + + + pubmed:18930136 + + p(HGNC:WDFY3) regulates a(GO:aggresome) + + + + + + + pubmed:18930136 + + tloc(p(HGNC:WDFY3), fromLoc(GO:nucleus), toLoc(GO:cytoplasm)) increases bp(GO:"protein ubiquitination") + + + + + + + pubmed:18930136 + + p(HGNC:WDFY3) increases bp(GO:"ubiquitin-dependent protein catabolic process") + + + + + + + pubmed:18930136 + + bp(GO:"Hsp90 deacetylation") increases act(p(HGNC:HSF1)) + + + + + + + pubmed:18930136 + + a(MESH:"Huntingtin Protein") association p(HGNC:SQSTM1) + + + + + + + pubmed:24563850 + + act(p(HGNC:XDH)) increases a(CHEBI:radical) + + + + + + + pubmed:24563850 + + act(p(HGNC:XDH)) increases a(CHEBI:"reactive oxygen species") + + + + + + + pubmed:24563850 + + act(p(HGNCGENEFAMILY:"Cytochrome P450 family 1")) increases a(CHEBI:radical) + + + + + + + pubmed:24563850 + + act(p(HGNCGENEFAMILY:"Cytochrome P450 family 1")) increases a(CHEBI:"reactive oxygen species") + + + + + + + pubmed:24563850 + + act(a(MESH:Peroxisomes)) increases a(CHEBI:radical) + + + + + + + pubmed:24563850 + + bp(GO:"response to radiation") increases a(CHEBI:radical) + + + + + + + pubmed:24563850 + + a(MESH:"Air Pollution") increases a(CHEBI:radical) + + + + + + + pubmed:24563850 + + bp(MESH:"Host-Pathogen Interactions") association a(CHEBI:radical) + + + + + + + pubmed:24563850 + + bp(CONSO:"non-enzymatic protein modification") positiveCorrelation bp(GO:aging) + + + + + + + pubmed:24563850 + + bp(CONSO:"non-enzymatic protein modification") increases bp(CONSO:misfolding) + + + + + + + pubmed:24563850 + + p(HGNCGENEFAMILY:"Small heat shock proteins") decreases path(MESH:"Protein Aggregation, Pathological") + + + + + + + pubmed:24563850 + + bp(GO:"post-translational protein modification") regulates p(HGNCGENEFAMILY:"Small heat shock proteins") + + + + + + + pubmed:24563850 + + bp(GO:"cellular response to heat") increases p(HGNC:HSPA1A, loc(MESH:"Extracellular Space")) + + + + + + + + + + + + + pubmed:24563850 + + p(HGNC:CAT) increases rxn(reactants(a(CHEBI:"hydrogen peroxide")), products(a(CHEBI:dioxygen), a(CHEBI:water))) + + + + + + + + + + + + + pubmed:29626319 + + tloc(a(CHEBI:water), fromLoc(GO:"extracellular region"), toLoc(MESH:"Cerebrospinal Fluid")) decreases a(CHEBI:amyloid-beta) + + + + + + + pubmed:24563850 + + p(HGNC:GPX1) increases rxn(reactants(a(CHEBI:"hydrogen peroxide")), products(a(CHEBI:water))) + + + + + + + + + + + pubmed:24563850 + + complex(p(HGNC:MAF), p(HGNC:NFE2L2)) increases p(HGNC:NQO1) + + + + + + + pubmed:24563850 + + complex(p(HGNC:MAF), p(HGNC:NFE2L2)) increases p(HGNC:HMOX1) + + + + + + + pubmed:24563850 + + complex(p(HGNC:MAF), p(HGNC:NFE2L2)) increases p(HGNC:GCLC) + + + + + + + pubmed:24563850 + + complex(p(HGNC:MAF), p(HGNC:NFE2L2)) increases p(FPLX:GST) + + + + + + + + + pubmed:24563850 + + bp(GO:"protein oxidation") association bp(GO:aging) + + + + + + + pubmed:24563850 + + bp(GO:"protein oxidation") association path(MESH:"Cardiovascular Diseases") + + + + + + + pubmed:24563850 + + bp(GO:"protein oxidation") association bp(HP:Neurodegeneration) + + + + + + + pubmed:24563850 + + bp(GO:"protein oxidation") association path(MESH:Neoplasms) + + + + + + + pubmed:29024336 + + bp(GO:"protein oxidation") increases tloc(p(MGI:Mapt), fromLoc(MESH:"Extracellular Space"), toLoc(GO:"multivesicular body")) + + + + + + + pubmed:24563850 + + path(MESH:"Cardiovascular Diseases") association bp(GO:"protein oxidation") + + + + + + + pubmed:26195256 + + path(MESH:"Cardiovascular Diseases") increases path(MESH:"Alzheimer Disease") + + + + + + + pubmed:19732809 + + path(MESH:"Cardiovascular Diseases") negativeCorrelation p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) + + + + + + + pubmed:24563850 + + bp(MESH:"Protein Carbonylation") increases a(MESH:"Protein Aggregates") + + + + + + + pubmed:24563850 + + act(p(FPLX:PRDX)) decreases a(MESH:"Protein Aggregates") + + + + + + + + + + + + + + + + + + + + + + + + + + + pubmed:25036637 + + p(INTERPRO:"Heat shock protein 70 family") directlyIncreases complex(p(HGNC:BAG2), p(HGNC:HSPA8), p(HGNC:RPN1), p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) + + + + + + + + + pubmed:25036637 + + p(INTERPRO:"Heat shock protein 70 family") directlyIncreases complex(p(HGNC:HSF1), p(HGNC:TP53), p(INTERPRO:"Heat shock protein 70 family")) + + + + + + + + + + + pubmed:21882945 + + p(INTERPRO:"Heat shock protein 70 family") increases bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") + + + + + + + pubmed:21882945 + + p(INTERPRO:"Heat shock protein 70 family") increases bp(GO:"proteasomal protein catabolic process") + + + + + + + pubmed:21882945 + + p(INTERPRO:"Heat shock protein 70 family") increases bp(GO:autophagy) + + + + + + + pubmed:21882945 + + p(INTERPRO:"Heat shock protein 70 family") increases act(p(HGNC:STUB1)) + + + + + + + pubmed:21882945 + + p(INTERPRO:"Heat shock protein 70 family") increases bp(GO:"protein catabolic process") + + + + + + + pubmed:21882945 + + p(INTERPRO:"Heat shock protein 70 family") increases complex(a(GO:microtubule), p(HGNC:MAPT)) + + + + + + + pubmed:21882945 + + act(p(INTERPRO:"Heat shock protein 70 family"), ma(GO:"ATPase activity")) decreases deg(p(HGNC:MAPT)) + + + + + + + pubmed:21882945 + + act(p(INTERPRO:"Heat shock protein 70 family")) increases p(HGNC:MAPT) + + + + + + + pubmed:21882945 + + act(p(INTERPRO:"Heat shock protein 70 family")) increases p(HGNC:MAPT) + + + + + + + + + + + + + + + + + + + + + pubmed:18500754 + + p(INTERPRO:"Heat shock protein 70 family") association complex(GO:microtubule) + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + pubmed:25036637 + + p(INTERPRO:"Heat shock protein Hsp90 family") association p(INTERPRO:"NudC family") + + + + + + + + + + + + + pubmed:25036637 + + p(HGNC:DNAJC7) increases complex(p(HGNC:DNAJC7), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) + + + + + + + + + pubmed:25036637 + + p(HGNC:DNAJB6) increases complex(p(HGNC:DNAJB6), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) + + + + + + + pubmed:30837838 + + p(HGNC:DNAJB6) decreases p(MESH:"Heat-Shock Proteins") + + + + + + + + + pubmed:25036637 + + p(HGNC:HSPBP1) increases complex(p(HGNC:HSPBP1), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) + + + + + + + + + pubmed:25036637 + + p(HGNC:EDRF1) increases complex(p(HGNC:EDRF1), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) + + + + + + + + + pubmed:25036637 + + p(HGNC:RNF41) increases complex(p(HGNC:RNF41), p(INTERPRO:"Heat shock protein 70 family"), p(INTERPRO:"Heat shock protein Hsp90 family")) + + + + + + + + + pubmed:25036637 + + p(HGNC:CDC37L1) directlyIncreases complex(p(HGNC:CDC37L1), p(INTERPRO:"Heat shock protein Hsp90 family")) + + + + + + + + + pubmed:25036637 + + p(HGNC:CDC37L1) directlyIncreases complex(p(HGNC:CDC37L1), p(HGNC:STIP1)) + + + + + + + + + + + pubmed:25036637 + + p(INTERPRO:"Cdc37, N-terminal domain") increases act(p(HGNC:CDC37)) + + + + + + + + + + + pubmed:25036637 + + complex(p(HGNC:CDC37L1), p(INTERPRO:"Cdc37, N-terminal domain")) regulates complex(p(HGNC:ARAF), p(HGNC:CDC37L1), p(INTERPRO:"Cdc37, N-terminal domain")) + + + + + + + + + + + + + pubmed:25036637 + + p(INTERPRO:"Tetratricopeptide repeat") increases complex(a(MESH:"Tacrolimus Binding Proteins"), p(INTERPRO:"Heat shock protein Hsp90 family")) + + + + + + + + + + + pubmed:25036637 + + p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:AURKB), p(HGNC:FKBP5)) + + + + + + + + + pubmed:25036637 + + p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:CDK11A), p(HGNC:FKBP5)) + + + + + + + + + pubmed:25036637 + + p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:CDK1), p(HGNC:FKBP5)) + + + + + + + + + pubmed:25036637 + + p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:FKBP5), p(HGNC:IKBKG)) + + + + + + + + + pubmed:25036637 + + p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:CDK4), p(HGNC:FKBP5)) + + + + + + + + + pubmed:25036637 + + p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:FER), p(HGNC:FKBP5)) + + + + + + + + + pubmed:25036637 + + p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:FKBP5), p(HGNC:IKBKB)) + + + + + + + + + pubmed:25036637 + + p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:CHUK), p(HGNC:FKBP5)) + + + + + + + + + pubmed:25036637 + + p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:FKBP5), p(HGNC:RAF1)) + + + + + + + + + pubmed:25036637 + + p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:ABL2), p(HGNC:FKBP5)) + + + + + + + + + pubmed:25036637 + + p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:ARAF), p(HGNC:FKBP5)) + + + + + + + pubmed:25036637 + + p(HGNC:FKBP5) association p(HGNC:CDC37) + + + + + + + + + pubmed:25036637 + + p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:AGO1), p(HGNC:FKBP5)) + + + + + + + + + pubmed:25036637 + + p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:AGO2), p(HGNC:FKBP5)) + + + + + + + pubmed:25036637 + + p(HGNC:FKBP5) association p(HGNC:EGLN1) + + + + + + + pubmed:25036637 + + p(HGNC:FKBP5) association p(HGNC:PDCD2) + + + + + + + pubmed:25036637 + + p(HGNC:FKBP5) association p(HGNC:ANKMY2) + + + + + + + + + pubmed:25036637 + + p(HGNC:FKBP5) increases complex(p(HGNC:FKBP5), p(HGNC:MCM4)) + + + + + + + + + pubmed:25036637 + + p(HGNC:FKBP5) increases complex(p(HGNC:FKBP5), p(HGNC:MCMBP)) + + + + + + + pubmed:25036637 + + p(HGNC:FKBP5) regulates bp(GO:"cellular response to DNA damage stimulus") + + + + + + + + + + + pubmed:21882945 + + p(HGNC:FKBP5) regulates complex(a(GO:microtubule), p(HGNC:MAPT)) + + + + + + + pubmed:21882945 + + p(HGNC:FKBP5) increases complex(p(FPLX:HSP90), p(HGNC:MAPT)) + + + + + + + pubmed:20071522 + + p(HGNC:FKBP5) positiveCorrelation complex(p(FPLX:HSP90), p(HGNC:MAPT)) + + + + + + + + + pubmed:21882945 + + p(HGNC:FKBP5) directlyIncreases complex(p(HGNC:FKBP5), p(HGNC:MAPT)) + + + + + + + pubmed:20071522 + + p(HGNC:FKBP5) isA complex(p(HGNC:FKBP5), p(HGNC:MAPT)) + + + + + + + pubmed:21882945 + + p(HGNC:FKBP5) positiveCorrelation bp(GO:aging) + + + + + + + pubmed:21882945 + + p(HGNC:FKBP5) increases p(HGNC:MAPT) + + + + + + + pubmed:20071522 + + p(HGNC:FKBP5) increases p(HGNC:MAPT) + + + + + + + pubmed:21882945 + + p(HGNC:FKBP5) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + + + pubmed:29311797 + + p(HGNC:FKBP5) isA a(MESH:Immunophilins) + + + + + + + pubmed:20071522 + + p(HGNC:FKBP5) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) + + + + + + + pubmed:20071522 + + p(HGNC:FKBP5) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) + + + + + + + pubmed:20071522 + + p(HGNC:FKBP5) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) + + + + + + + pubmed:20071522 + + p(HGNC:FKBP5) negativeCorrelation complex(p(HGNC:AHSA1), p(HGNC:MAPT)) + + + + + + + pubmed:20071522 + + p(HGNC:FKBP5) decreases complex(p(HGNC:MAPT), p(HGNC:PTGES3)) + + + + + + + pubmed:20071522 + + p(HGNC:FKBP5) increases bp(GO:"microtubule polymerization") + + + + + + + + + + + + + + + + + + + + + pubmed:10391244 + + act(p(HGNC:CDK1), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) + + + + + + + pubmed:10391244 + + p(HGNC:CDK1) positiveCorrelation complex(GO:"neurofibrillary tangle") + + + + + + + + + + + + + + + pubmed:29686391 + + p(HGNC:CDK4) decreases tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + + + + + + + + + + + + + + + + + pubmed:26631930 + + p(HGNC:ABL2) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 394)) + + + + + + + + + + + pubmed:25036637 + + p(HGNC:AGO1) directlyIncreases complex(p(HGNC:AGO1), p(INTERPRO:"Heat shock protein Hsp90 family")) + + + + + + + pubmed:25036637 + + p(HGNC:AGO1) directlyIncreases complex(p(HGNC:AGO2), p(INTERPRO:"Heat shock protein Hsp90 family")) + + + + + + + pubmed:25036637 + + p(HGNC:AGO1) positiveCorrelation bp(GO:"ribonucleoprotein complex biogenesis") + + + + + + + + + + + pubmed:25036637 + + p(HGNC:AGO2) positiveCorrelation bp(GO:"ribonucleoprotein complex biogenesis") + + + + + + + pubmed:25036637 + + bp(GO:"ribonucleoprotein complex biogenesis") positiveCorrelation p(HGNC:AGO1) + + + + + + + pubmed:25036637 + + bp(GO:"ribonucleoprotein complex biogenesis") positiveCorrelation p(HGNC:AGO2) + + + + + + + pubmed:25036637 + + p(INTERPRO:"Zinc finger, MYND-type") association p(HGNC:EGLN1) + + + + + + + pubmed:25036637 + + p(INTERPRO:"Zinc finger, MYND-type") increases complex(p(HGNC:EGLN1), p(INTERPRO:"Heat shock protein Hsp90 family")) + + + + + + + pubmed:25036637 + + p(INTERPRO:"Zinc finger, MYND-type") association p(HGNC:PDCD2) + + + + + + + pubmed:25036637 + + p(INTERPRO:"Zinc finger, MYND-type") increases complex(p(HGNC:PDCD2), p(INTERPRO:"Heat shock protein Hsp90 family")) + + + + + + + pubmed:25036637 + + p(INTERPRO:"Zinc finger, MYND-type") association p(HGNC:ANKMY2) + + + + + + + pubmed:25036637 + + p(INTERPRO:"Zinc finger, MYND-type") increases complex(p(HGNC:ANKMY2), p(INTERPRO:"Heat shock protein Hsp90 family")) + + + + + + + pubmed:25036637 + + p(HGNC:PDCD2) association p(HGNC:FKBP5) + + + + + + + pubmed:25036637 + + p(HGNC:PDCD2) association p(INTERPRO:"Zinc finger, MYND-type") + + + + + + + + + pubmed:25036637 + + p(HGNC:ANKMY2) association p(HGNC:FKBP5) + + + + + + + pubmed:25036637 + + p(HGNC:ANKMY2) association p(INTERPRO:"Zinc finger, MYND-type") + + + + + + + + + + + + + pubmed:25036637 + + p(HGNC:MCM4) increases bp(GO:"DNA replication initiation") + + + + + + + pubmed:25036637 + + p(HGNC:MCM4) increases bp(GO:"replication fork progression beyond termination site") + + + + + + + + + + + pubmed:25036637 + + p(HGNC:MCMBP) increases complex(p(HGNC:FKBP5), p(HGNC:MCMBP)) + + + + + + + + + pubmed:25036637 + + p(HGNC:MCMBP) increases bp(GO:"DNA replication initiation") + + + + + + + pubmed:25036637 + + p(HGNC:MCMBP) increases bp(GO:"replication fork progression beyond termination site") + + + + + + + + + pubmed:25036637 + + p(HGNC:MCMBP) increases complex(p(HGNC:MCM2), p(HGNC:MCMBP)) + + + + + + + + + pubmed:25036637 + + p(HGNC:MCMBP) increases complex(p(HGNC:MCM3), p(HGNC:MCMBP)) + + + + + + + + + pubmed:25036637 + + p(HGNC:MCMBP) increases complex(p(HGNC:MCM4), p(HGNC:MCMBP)) + + + + + + + + + pubmed:25036637 + + p(HGNC:MCMBP) increases complex(p(HGNC:MCM5), p(HGNC:MCMBP)) + + + + + + + + + pubmed:25036637 + + p(HGNC:MCMBP) increases complex(p(HGNC:MCM6), p(HGNC:MCMBP)) + + + + + + + + + pubmed:25036637 + + p(HGNC:MCMBP) increases complex(p(HGNC:MCM7), p(HGNC:MCMBP)) + + + + + + + + + pubmed:25036637 + + p(HGNC:MCMBP) increases complex(p(HGNC:MCM9), p(HGNC:MCMBP)) + + + + + + + + + pubmed:25036637 + + p(HGNC:MCMBP) increases complex(p(HGNC:MCM8), p(HGNC:MCMBP)) + + + + + + + + + pubmed:25036637 + + p(HGNC:MCMBP) increases complex(p(HGNC:KEAP1), p(HGNC:MCMBP)) + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + pubmed:23702978 + + bp(GO:"cellular response to DNA damage stimulus") increases complex(GO:ripoptosome) + + + + + + + + + pubmed:25036637 + + p(HGNC:FKBP8) increases complex(p(HGNC:FKBP8), p(HGNC:PDCL)) + + + + + + + pubmed:25036637 + + p(HGNC:FKBP8) association bp(GO:"G protein-coupled receptor signaling pathway") + + + + + + + pubmed:29311797 + + p(HGNC:FKBP8) isA a(MESH:Immunophilins) + + + + + + + + + + + pubmed:25036637 + + p(HGNC:PDCL) association p(INTERPRO:"G-protein, gamma subunit") + + + + + + + pubmed:25036637 + + p(HGNC:PDCL) isA a(MESH:"Molecular Chaperones") + + + + + + + pubmed:25036637 + + bp(GO:"G protein-coupled receptor signaling pathway") association p(HGNC:FKBP8) + + + + + + + pubmed:25036637 + + p(INTERPRO:"G-protein, gamma subunit") association p(HGNC:PDCL) + + + + + + + + + pubmed:25036637 + + p(HGNC:FKBP6) increases complex(p(HGNC:FKBP6), p(HGNC:OSBP)) + + + + + + + pubmed:29311797 + + p(HGNC:FKBP6) isA a(MESH:Immunophilins) + + + + + + + + + + + pubmed:25036637 + + a(CONSO:OSW-1) decreases complex(p(HGNC:FKBP6), p(HGNC:OSBP)) + + + + + + + pubmed:25036637 + + p(INTERPRO:"BAG domain") regulates act(p(INTERPRO:"Heat shock protein 70 family")) + + + + + + + + + pubmed:25036637 + + p(HGNC:LTN1) association bp(GO:"protein quality control for misfolded or incompletely synthesized proteins") + + + + + + + + + pubmed:25036637 + + p(HGNC:BAG5) increases complex(p(HGNC:BAG5), p(HGNC:MAD1L1)) + + + + + + + + + pubmed:25036637 + + p(HGNC:BAG5) increases complex(p(HGNC:BAG5), p(HGNC:MAD2L1)) + + + + + + + + + + + + + + + + + pubmed:25036637 + + p(HGNC:BAG4) increases complex(p(HGNC:BAG4), p(HGNC:DCP1A)) + + + + + + + + + pubmed:25036637 + + p(HGNC:BAG4) increases complex(p(HGNC:BAG4), p(HGNC:EDC3)) + + + + + + + + + pubmed:25036637 + + p(HGNC:BAG4) increases complex(p(HGNC:BAG4), p(HGNC:DDX6)) + + + + + + + pubmed:25036637 + + p(HGNC:BAG4) negativeCorrelation complex(GO:P-body) + + + + + + + + + + + + + pubmed:25036637 + + p(HGNC:BAG4) directlyIncreases complex(p(HGNC:BAG4), p(HGNC:HSPB1)) + + + + + + + + + pubmed:25036637 + + p(HGNC:BAG4) directlyIncreases complex(p(HGNC:BAG4), p(HGNC:DCP1B)) + + + + + + + + + pubmed:25036637 + + p(HGNC:DCP1A) isA complex(GO:P-body) + + + + + + + pubmed:25036637 + + p(HGNC:DCP1A) association bp(GO:"cellular protein catabolic process") + + + + + + + pubmed:25036637 + + p(HGNC:DCP1A) association bp(GO:"gene silencing") + + + + + + + pubmed:25036637 + + p(HGNC:DCP1A) decreases bp(GO:"7-methylguanosine mRNA capping") + + + + + + + pubmed:25036637 + + p(HGNC:DCP1A) decreases bp(GO:"mRNA stabilization") + + + + + + + pubmed:25036637 + + p(HGNC:DCP1A) increases bp(GO:"translational termination") + + + + + + + + + pubmed:25036637 + + p(HGNC:EDC3) isA complex(GO:P-body) + + + + + + + pubmed:25036637 + + p(HGNC:EDC3) association bp(GO:"cellular protein catabolic process") + + + + + + + pubmed:25036637 + + p(HGNC:EDC3) association bp(GO:"gene silencing") + + + + + + + pubmed:25036637 + + p(HGNC:EDC3) decreases bp(GO:"7-methylguanosine mRNA capping") + + + + + + + pubmed:25036637 + + p(HGNC:EDC3) decreases bp(GO:"mRNA stabilization") + + + + + + + pubmed:25036637 + + p(HGNC:EDC3) increases bp(GO:"translational termination") + + + + + + + + + pubmed:25036637 + + p(HGNC:DDX6) isA complex(GO:P-body) + + + + + + + pubmed:25036637 + + p(HGNC:DDX6) association bp(GO:"cellular protein catabolic process") + + + + + + + pubmed:25036637 + + p(HGNC:DDX6) association bp(GO:"gene silencing") + + + + + + + pubmed:25036637 + + p(HGNC:DDX6) decreases bp(GO:"7-methylguanosine mRNA capping") + + + + + + + pubmed:25036637 + + p(HGNC:DDX6) decreases bp(GO:"mRNA stabilization") + + + + + + + pubmed:25036637 + + p(HGNC:DDX6) increases bp(GO:"translational termination") + + + + + + + pubmed:25036637 + + complex(GO:P-body) negativeCorrelation p(HGNC:BAG4) + + + + + + + pubmed:25036637 + + complex(GO:P-body) association p(HGNC:BAG4, var("p.Asp424Ala")) + + + + + + + pubmed:25036637 + + complex(GO:P-body) negativeCorrelation p(HGNC:BAG4, var("p.Asp424Ala")) + + + + + + + pubmed:27181519 + + complex(GO:P-body) isA complex(GO:"ribonucleoprotein granule") + + + + + + + pubmed:27181519 + + complex(GO:P-body) regulates a(MESH:"RNA, Messenger") + + + + + + + pubmed:27181519 + + complex(GO:P-body) association bp(GO:"RNA catabolic process") + + + + + + + pubmed:27181519 + + complex(GO:P-body) regulates a(MESH:RNA) + + + + + + + + + pubmed:25036637 + + p(HGNC:BAG4, var("p.Asp424Ala")) decreases complex(p(HGNC:BAG4, var("p.Asp424Ala")), p(INTERPRO:"Heat shock protein 70 family")) + + + + + + + pubmed:25036637 + + p(HGNC:BAG4, var("p.Asp424Ala")) association complex(GO:P-body) + + + + + + + pubmed:25036637 + + p(HGNC:BAG4, var("p.Asp424Ala")) negativeCorrelation complex(GO:P-body) + + + + + + + pubmed:25036637 + + a(PUBCHEM:23624255) decreases act(p(INTERPRO:"Heat shock protein Hsp90 family")) + + + + + + + pubmed:25036637 + + a(PUBCHEM:23624255) decreases complex(p(HGNC:HSP90AB1), p(HGNC:RPAP3)) + + + + + + + pubmed:25036637 + + a(PUBCHEM:23624255) decreases complex(p(HGNC:HSP90AB1), p(HGNC:SUGT1)) + + + + + + + pubmed:25036637 + + a(PUBCHEM:23624255) decreases complex(p(HGNC:HSP90AB1), p(HGNC:SUGT1)) + + + + + + + pubmed:25036637 + + a(PUBCHEM:23624255) decreases complex(p(HGNC:FKBP4), p(HGNC:HSP90AB1)) + + + + + + + pubmed:25036637 + + a(PUBCHEM:23624255) decreases complex(p(HGNC:FKBP4), p(HGNC:HSP90AB1)) + + + + + + + pubmed:25036637 + + a(PUBCHEM:23624255) increases complex(p(HGNC:BAG3), p(HGNC:HSPA8)) + + + + + + + pubmed:25036637 + + a(PUBCHEM:23624255) increases complex(p(HGNC:BAG1), p(HGNC:HSPA8)) + + + + + + + pubmed:25036637 + + a(PUBCHEM:23624255) increases complex(p(HGNC:BAG4), p(HGNC:HSPA8)) + + + + + + + pubmed:25036637 + + a(PUBCHEM:23624255) increases complex(p(HGNC:BAG5), p(HGNC:HSPA8)) + + + + + + + pubmed:25036637 + + a(PUBCHEM:23624255) increases complex(p(HGNC:BAG2), p(HGNC:HSPA8)) + + + + + + + pubmed:25036637 + + a(PUBCHEM:23624255) decreases complex(p(HGNC:FKBP5), p(HGNC:HSP90AB1)) + + + + + + + pubmed:25036637 + + a(PUBCHEM:23624255) decreases complex(p(HGNC:HSPA8), p(HGNC:SUGT1)) + + + + + + + pubmed:25036637 + + a(PUBCHEM:23624255) decreases complex(p(HGNC:FKBP4), p(HGNC:HSPA8)) + + + + + + + pubmed:25036637 + + a(PUBCHEM:23624255) decreases complex(p(HGNC:FKBP5), p(HGNC:HSPA8)) + + + + + + + pubmed:25036637 + + a(PUBCHEM:23624255) increases complex(p(HGNC:HSP90AB1), p(HGNC:SIRT6)) + + + + + + + pubmed:25036637 + + a(PUBCHEM:23624255) increases complex(p(HGNC:AR), p(HGNC:HSP90AB1)) + + + + + + + pubmed:25036637 + + a(PUBCHEM:23624255) increases complex(p(HGNC:HSPA8), p(HGNC:SIRT6)) + + + + + + + pubmed:25036637 + + a(PUBCHEM:23624255) increases complex(p(HGNC:AR), p(HGNC:HSPA8)) + + + + + + + + + + + + + pubmed:25036637 + + p(HGNC:RPAP3) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5), p(HGNC:RPAP3)) + + + + + + + + + + + + + pubmed:25036637 + + p(HGNC:RPAP3) directlyIncreases complex(p(HGNC:RPAP3), p(HGNC:RPAP3)) + + + + + + + + + pubmed:25036637 + + p(HGNC:RPAP3) directlyIncreases complex(p(FPLX:HSP90), p(HGNC:RPAP3)) + + + + + + + + + + + + + pubmed:25036637 + + p(HGNC:SUGT1) directlyIncreases complex(p(HGNC:SUGT1), p(INTERPRO:"Leucine-rich repeat domain superfamily")) + + + + + + + + + pubmed:25036637 + + p(HGNC:SUGT1) directlyIncreases complex(p(HGNC:SUGT1), p(INTERPRO:"Leucine-rich repeat")) + + + + + + + + + + + + + pubmed:29311797 + + p(HGNC:FKBP4) isA a(MESH:Immunophilins) + + + + + + + + + + + pubmed:26631930 + + p(HGNC:FKBP4) increases a(CONSO:"Tau aggregates") + + + + + + + + + + + pubmed:26903089 + + act(p(HGNC:FKBP4)) association p(CONSO:"VQIVYK motif") + + + + + + + + + + + + + + + pubmed:21882945 + + p(HGNC:BAG2) directlyIncreases complex(p(HGNC:BAG2), p(HGNC:MAPT), p(INTERPRO:"Heat shock protein 70 family")) + + + + + + + pubmed:21882945 + + p(HGNC:BAG2) association deg(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) + + + + + + + pubmed:21882945 + + p(HGNC:BAG2) decreases act(p(HGNC:STUB1)) + + + + + + + pubmed:21882945 + + p(HGNC:BAG2) decreases bp(GO:"protein ubiquitination") + + + + + + + pubmed:21882945 + + p(HGNC:BAG2) decreases complex(p(HGNC:STUB1), p(HGNC:UBA2)) + + + + + + + + + + + + + + + + + pubmed:25036637 + + p(HGNC:PSMC1) directlyIncreases complex(p(HGNC:PSMC1), p(HGNC:PSMC2)) + + + + + + + + + pubmed:25036637 + + p(HGNC:PSMC1) directlyIncreases complex(p(HGNC:PSMC1), p(HGNC:PSMD2)) + + + + + + + + + + + pubmed:25036637 + + p(HGNC:PFDN2) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5)) + + + + + + + pubmed:25036637 + + p(HGNC:PFDN2) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5)) + + + + + + + + + + + + + + + + + + + + + + + pubmed:25036637 + + p(HGNC:PFDN2) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN2)) + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + pubmed:25036637 + + p(INTERPRO:"BAG domain superfamily") directlyIncreases complex(p(HGNC:HSPA6), p(INTERPRO:"BAG domain superfamily")) + + + + + + + + + pubmed:25036637 + + p(INTERPRO:"BAG domain superfamily") directlyIncreases complex(p(HGNC:HSPA8), p(INTERPRO:"BAG domain superfamily")) + + + + + + + + + + + pubmed:25036637 + + p(HGNC:UNC45A) directlyIncreases complex(p(HGNC:HSP90AB1), p(HGNC:UNC45A)) + + + + + + + + + + + + + + + + + + + pubmed:25036637 + + p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:BAG1), p(HGNC:PSMD2)) + + + + + + + + + pubmed:25036637 + + p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:BAG2), p(HGNC:PSMD2)) + + + + + + + + + pubmed:25036637 + + p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:BAG3), p(HGNC:PSMD2)) + + + + + + + + + pubmed:25036637 + + p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:BAG5), p(HGNC:PSMD2)) + + + + + + + + + pubmed:25036637 + + p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:PSMD2), p(HGNC:STUB1)) + + + + + + + + + + + + + pubmed:25036637 + + p(HGNC:PSMD2) directlyIncreases complex(p(HGNC:PSMD2), p(INTERPRO:"Heat shock protein 70 family")) + + + + + + + + + + + + + pubmed:21882945 + + complex(p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) increases deg(p(HGNC:MAPT)) + + + + + + + + + + + pubmed:25036637 + + p(HGNC:VBP1) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5), p(HGNC:VBP1)) + + + + + + + + + pubmed:25036637 + + p(HGNC:VBP1) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:VBP1)) + + + + + + + + + pubmed:25036637 + + p(HGNC:VBP1) directlyIncreases complex(p(HGNC:PFDN5), p(HGNC:VBP1)) + + + + + + + + + + + pubmed:25036637 + + p(HGNC:UXT) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5), p(HGNC:UXT)) + + + + + + + + + pubmed:25036637 + + p(HGNC:UXT) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:UXT)) + + + + + + + + + pubmed:25036637 + + p(HGNC:UXT) directlyIncreases complex(p(HGNC:PFDN5), p(HGNC:UXT)) + + + + + + + + + + + pubmed:25036637 + + p(HGNC:PDRG1) directlyIncreases complex(p(HGNC:PDRG1), p(HGNC:PFDN2), p(HGNC:PFDN5)) + + + + + + + + + pubmed:25036637 + + p(HGNC:PDRG1) directlyIncreases complex(p(HGNC:PDRG1), p(HGNC:PFDN2)) + + + + + + + + + pubmed:25036637 + + p(HGNC:PDRG1) directlyIncreases complex(p(HGNC:PDRG1), p(HGNC:PFDN5)) + + + + + + + + + + + pubmed:25036637 + + p(HGNC:POLR3A) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5), p(HGNC:POLR3A)) + + + + + + + + + pubmed:25036637 + + p(HGNC:POLR3A) directlyIncreases complex(p(HGNC:POLR3A), p(HGNC:RPAP3)) + + + + + + + + + pubmed:25036637 + + p(HGNC:POLR3A) directlyIncreases complex(p(FPLX:HSP90), p(HGNC:POLR3A)) + + + + + + + + + + + pubmed:25036637 + + p(HGNC:URI1) directlyIncreases complex(p(HGNC:PFDN2), p(HGNC:PFDN5), p(HGNC:URI1)) + + + + + + + + + pubmed:25036637 + + p(HGNC:URI1) directlyIncreases complex(p(HGNC:RPAP3), p(HGNC:URI1)) + + + + + + + + + pubmed:25036637 + + p(HGNC:URI1) directlyIncreases complex(p(FPLX:HSP90), p(HGNC:URI1)) + + + + + + + + + pubmed:25036637 + + p(INTERPRO:"Leucine-rich repeat domain superfamily") directlyIncreases complex(p(HGNC:SUGT1), p(INTERPRO:"Leucine-rich repeat domain superfamily")) + + + + + + + + + pubmed:25036637 + + a(MESH:"Argonaute Proteins") directlyIncreases complex(a(MESH:"Argonaute Proteins"), p(HGNC:PPP5C)) + + + + + + + + + pubmed:25036637 + + a(MESH:"Argonaute Proteins") directlyIncreases complex(a(MESH:"Argonaute Proteins"), p(HGNC:PTGES3)) + + + + + + + + + pubmed:21882945 + + p(HGNC:PTGES3) increases complex(a(MESH:"Protein Kinases"), p(FPLX:HSP90)) + + + + + + + + + pubmed:29311797 + + p(HGNC:PTGES3) decreases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) + + + + + + + pubmed:29311797 + + p(HGNC:PTGES3) decreases path(MESH:"Protein Aggregation, Pathological") + + + + + + + pubmed:29311797 + + p(HGNC:PTGES3) increases p(HGNC:MAPT) + + + + + + + pubmed:29311797 + + p(HGNC:PTGES3) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:29311797 + + p(HGNC:PTGES3) decreases bp(GO:"cell death in response to oxidative stress") + + + + + + + + + pubmed:25036637 + + p(INTERPRO:"NudC family") association p(INTERPRO:"Heat shock protein Hsp90 family") + + + + + + + + + pubmed:25036637 + + p(HGNC:NUDC) directlyIncreases complex(p(HGNC:NUDC), p(INTERPRO:"WD40-repeat-containing domain superfamily")) + + + + + + + + + pubmed:25036637 + + p(HGNC:NUDC) directlyIncreases complex(p(HGNC:NUDC), p(INTERPRO:"WD40-repeat-containing domain")) + + + + + + + pubmed:25036637 + + p(HGNC:NUDC) directlyIncreases complex(p(HGNC:NUDC), p(INTERPRO:"WD40-repeat-containing domain")) + + + + + + + + + + + pubmed:25036637 + + p(HGNC:NUDCD3) directlyIncreases complex(p(HGNC:KLHL13), p(HGNC:NUDCD3)) + + + + + + + + + pubmed:25036637 + + p(HGNC:NUDCD3) directlyIncreases complex(p(HGNC:KLHL1), p(HGNC:NUDCD3)) + + + + + + + + + pubmed:25036637 + + p(HGNC:NUDCD3) directlyIncreases complex(p(HGNC:ENC1), p(HGNC:NUDCD3)) + + + + + + + + + pubmed:25036637 + + p(HGNC:NUDCD3) directlyIncreases complex(p(HGNC:NUDCD3), p(INTERPRO:"Kelch-type beta propeller")) + + + + + + + pubmed:25036637 + + p(HGNC:NUDCD3) directlyIncreases complex(p(HGNC:NUDCD3), p(INTERPRO:"Kelch-type beta propeller")) + + + + + + + + + + + + + + + pubmed:25036637 + + p(HGNC:NUDCD2) directlyIncreases complex(p(HGNC:FBXO24), p(HGNC:NUDCD2)) + + + + + + + + + pubmed:25036637 + + p(HGNC:NUDCD2) directlyIncreases complex(p(HGNC:NUDCD2), p(HGNC:SNX31)) + + + + + + + + + pubmed:25036637 + + p(HGNC:NUDCD2) directlyIncreases complex(p(HGNC:NUDCD2), p(INTERPRO:"Regulator of chromosome condensation, RCC1")) + + + + + + + pubmed:25036637 + + p(HGNC:NUDCD2) directlyIncreases complex(p(HGNC:NUDCD2), p(INTERPRO:"Regulator of chromosome condensation, RCC1")) + + + + + + + + + pubmed:25036637 + + p(HGNC:FBXO24) isA p(INTERPRO:"Regulator of chromosome condensation, RCC1") + + + + + + + + + + + + + + + pubmed:25036637 + + p(HGNC:CFAP100) directlyIncreases complex(p(HGNC:ARAF), p(HGNC:CDC37)) + + + + + + + + + + + pubmed:25036637 + + p(HGNC:NUDCD1) directlyIncreases complex(p(HGNC:NUDCD1), p(INTERPRO:"DEAD/DEAH box helicase domain")) + + + + + + + + + pubmed:25036637 + + p(HGNC:NUDCD1) directlyIncreases complex(a(GO:"COPI-coated vesicle"), p(HGNC:NUDCD1)) + + + + + + + + + + + pubmed:25036637 + + a(GO:"COPI-coated vesicle") regulates bp(GO:"retrograde transport, vesicle recycling within Golgi") + + + + + + + pubmed:24706768 + + a(CONSO:"polyQ aggregates") decreases act(p(HGNC:DNAJB1)) + + + + + + + pubmed:24706768 + + a(CONSO:"polyQ aggregates") decreases bp(GO:endocytosis) + + + + + + + pubmed:24706768 + + a(CONSO:"Q82 aggregates") decreases bp(GO:"clathrin-dependent endocytosis") + + + + + + + pubmed:24706768 + + p(HGNC:SOD1, var("p.Ala4Val")) decreases bp(GO:"clathrin-dependent endocytosis") + + + + + + + pubmed:24706768 + + complex(a(CONSO:"protein aggregates"), p(HGNC:HSPA8)) decreases bp(GO:"clathrin-dependent endocytosis") + + + + + + + pubmed:28803412 + + p(HGNC:SNCA, var("p.Glu46Lys")) increases path(MESH:"Parkinson Disease") + + + + + + + pubmed:28803412 + + p(HGNC:SNCA, var("p.His50Gln")) increases path(MESH:"Parkinson Disease") + + + + + + + pubmed:28803412 + + p(HGNC:SNCA, var("p.Gly51Asp")) increases path(MESH:"Parkinson Disease") + + + + + + + pubmed:28803412 + + p(HGNC:SNCA, var("p.Ala53Glu")) increases path(MESH:"Parkinson Disease") + + + + + + + pubmed:28803412 + + a(CONSO:CONSO00016) increases path(MESH:"Parkinson Disease") + + + + + + + pubmed:27075649 + + a(CONSO:CONSO00016) positiveCorrelation path(MESH:"Parkinson Disease") + + + + + + + pubmed:27075649 + + a(CONSO:CONSO00016) positiveCorrelation path(MESH:"Multiple System Atrophy") + + + + + + + pubmed:27075649 + + a(CONSO:CONSO00016) positiveCorrelation path(MESH:"Lewy Body Disease") + + + + + + + pubmed:28803412 + + a(CONSO:CONSO00093) increases path(MESH:"Parkinson Disease") + + + + + + + pubmed:28803412 + + a(CONSO:CONSO00093) biomarkerFor path(MESH:"Parkinson Disease") + + + + + + + pubmed:28803412 + + a(CONSO:CONSO00093) positiveCorrelation path(MESH:"Parkinson Disease") + + + + + + + pubmed:28803412 + + a(CONSO:CONSO00093) increases a(CONSO:CONSO00092) + + + + + + + pubmed:27075649 + + a(CONSO:CONSO00093) negativeCorrelation a(CONSO:CONSO00092) + + + + + + + pubmed:28803412 + + a(CONSO:CONSO00093) increases bp(GO:"apoptotic process") + + + + + + + pubmed:28803412 + + a(CONSO:CONSO00093) increases bp(GO:"apoptotic process") + + + + + + + pubmed:27075649 + + a(CONSO:CONSO00093) increases bp(GO:"apoptotic process") + + + + + + + pubmed:28803412 + + a(CONSO:CONSO00093) decreases a(MESH:Mitochondria) + + + + + + + pubmed:28803412 + + a(CONSO:CONSO00093) increases path(CONSO:CONSO00037) + + + + + + + pubmed:28803412 + + a(CONSO:CONSO00093) increases bp(MESH:"Endoplasmic Reticulum Stress") + + + + + + + pubmed:28803412 + + a(CONSO:CONSO00093) decreases act(complex(GO:"proteasome complex")) + + + + + + + pubmed:28803412 + + a(CONSO:CONSO00093) increases bp(GO:"microglial cell activation") + + + + + + + pubmed:28803412 + + a(CONSO:CONSO00093) increases bp(GO:"inflammatory response") + + + + + + + pubmed:28803412 + + a(CONSO:CONSO00093) increases act(p(HGNC:TLR2)) + + + + + + + pubmed:28803412 + + a(CONSO:CONSO00093) increases a(CHEBI:"reactive oxygen species") + + + + + + + pubmed:28803412 + + a(CONSO:CONSO00093) decreases a(MESH:"Cell Membrane") + + + + + + + pubmed:28803412 + + a(CONSO:CONSO00093) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(GO:"extracellular space"), toLoc(GO:"intracellular part")) + + + + + + + pubmed:27075649 + + a(CONSO:CONSO00093) increases a(CHEBI:"calcium(2+)") + + + + + + + + + pubmed:28803412 + + a(CONSO:CONSO00093) decreases bp(GO:"synaptic vesicle transport") + + + + + + + pubmed:28803412 + + a(CONSO:CONSO00093) decreases bp(GO:"axonal transport") + + + + + + + pubmed:28803412 + + a(CONSO:CONSO00093) decreases complex(a(GO:microtubule), a(MESH:Kinesin)) + + + + + + + pubmed:28803412 + + a(CONSO:CONSO00093) decreases a(MESH:"Golgi Apparatus") + + + + + + + pubmed:28803412 + + a(CONSO:CONSO00092) causesNoChange bp(GO:"apoptotic process") + + + + + + + pubmed:27075649 + + a(CONSO:CONSO00092) increases bp(GO:"apoptotic process") + + + + + + + pubmed:28803412 + + a(CONSO:CONSO00092) increases bp(GO:"inflammatory response") + + + + + + + pubmed:28803412 + + a(CONSO:CONSO00092) increases bp(GO:"microglial cell activation") + + + + + + + pubmed:27075649 + + a(CONSO:CONSO00092) increases a(CHEBI:"calcium(2+)") + + + + + + + pubmed:27075649 + + a(CONSO:CONSO00092) negativeCorrelation a(CONSO:CONSO00093) + + + + + + + pubmed:27075649 + + a(CONSO:CONSO00092) increases a(CONSO:CONSO00016) + + + + + + + pubmed:28803412 + + complex(a(CONSO:CONSO00093), p(HGNC:VAMP1)) decreases bp(GO:"SNARE complex assembly") + + + + + + + + + + + pubmed:26631930 + + act(a(MESH:Kinesin)) association p(HGNC:MAPT) + + + + + + + pubmed:28803412 + + p(HGNC:USP19) increases tloc(p(HGNC:SNCA), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:28803412 + + a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases a(CONSO:CONSO00016) + + + + + + + pubmed:28803412 + + a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases a(CONSO:CONSO00018) + + + + + + + pubmed:28803412 + + a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases a(CONSO:CONSO00017) + + + + + + + pubmed:29626319 + + a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:29626319 + + a(CHEBI:"(-)-epigallocatechin 3-gallate") increases r(HGNC:CALCOCO2) + + + + + + + pubmed:29626319 + + a(CHEBI:"(-)-epigallocatechin 3-gallate") increases r(HGNC:SQSTM1) + + + + + + + pubmed:28775333 + + a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases p(MGI:Dyrk1a) + + + + + + + pubmed:28775333 + + a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases p(CONSO:"3R tau") + + + + + + + pubmed:28775333 + + a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases path(MESH:Anxiety) + + + + + + + pubmed:28775333 + + a(CHEBI:"(-)-epigallocatechin 3-gallate") positiveCorrelation bp(GO:memory) + + + + + + + pubmed:28803412 + + p(CONSO:CONSO00094) decreases a(CONSO:CONSO00016) + + + + + + + pubmed:28803412 + + p(CONSO:CONSO00094) decreases bp(GO:"apoptotic process") + + + + + + + pubmed:27075649 + + path(MESH:"Multiple System Atrophy") positiveCorrelation a(CONSO:CONSO00016) + + + + + + + pubmed:27075649 + + a(CONSO:CONSO00095) increases bp(GO:"neuron death") + + + + + + + pubmed:27075649 + + a(CONSO:CONSO00095) decreases bp(GO:"ion homeostasis") + + + + + + + pubmed:27075649 + + a(CONSO:CONSO00095) increases a(CONSO:CONSO00016) + + + + + + + pubmed:27075649 + + a(CHEBI:glutaraldehyde) increases a(CONSO:CONSO00093) + + + + + + + pubmed:29807032 + + act(p(NCBIGENE:140621)) association bp(MESH:"Heat-Shock Response") + + + + + + + pubmed:29807032 + + p(NCBIGENE:492507) decreases act(p(NCBIGENE:140621)) + + + + + + + pubmed:29807032 + + path(MESH:"Stress Disorders, Traumatic") increases r(MESH:"corticotropin releasing factor-binding protein") + + + + + + + pubmed:23211705 + + p(MGI:Crh) decreases tloc(a(MESH:Estradiol), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:23211705 + + p(MGI:Crh) regulates p(HGNC:CGB3) + + + + + + + pubmed:23211705 + + p(MGI:Crh) decreases p(HGNC:CGB3) + + + + + + + pubmed:23211705 + + p(MGI:Crh) causesNoChange a(MESH:Progesterone) + + + + + + + pubmed:23211705 + + p(MGI:Crh) decreases a(MESH:Progesterone) + + + + + + + pubmed:23211705 + + p(MGI:Crh) decreases a(MESH:Progesterone) + + + + + + + + + pubmed:25125464 + + p(MGI:Crh) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) + + + + + + + pubmed:25125464 + + p(MGI:Crh) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 204)) + + + + + + + pubmed:25125464 + + p(MGI:Crh) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) + + + + + + + pubmed:25125464 + + p(MGI:Crh) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + + + + + + + pubmed:25125464 + + p(MGI:Crh) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) + + + + + + + pubmed:25125464 + + p(MGI:Crh) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) + + + + + + + pubmed:23211705 + + composite(a(MESH:antalarmin), p(MGI:Crh)) decreases tloc(p(HGNC:CGB3), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:8940412 + + act(p(RGD:Crh)) regulates a(MESH:"Adrenocorticotropic Hormone") + + + + + + + pubmed:8940412 + + act(p(RGD:Crh)) increases tloc(a(MESH:Glucocorticoids), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:8940412 + + act(p(RGD:Crh)) positiveCorrelation bp(GO:"inflammatory response") + + + + + + + pubmed:8940412 + + act(p(RGD:Crh)) directlyIncreases act(p(RGD:Crhr1)) + + + + + + + pubmed:8940412 + + a(CHEBI:antalarmin) directlyDecreases act(p(RGD:Crh)) + + + + + + + pubmed:8940412 + + a(CHEBI:antalarmin) decreases tloc(p(RGD:Crh), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:8940412 + + a(CHEBI:antalarmin) directlyDecreases act(p(RGD:Crhr1)) + + + + + + + pubmed:8940412 + + a(CHEBI:antalarmin) negativeCorrelation bp(GO:"inflammatory response") + + + + + + + pubmed:8940412 + + act(p(RGD:Crhr2)) decreases act(p(RGD:Crhr1)) + + + + + + + pubmed:30145931 + + a(CHEBI:"bafilomycin A1") decreases bp(GO:autophagy) + + + + + + + pubmed:26702100 + + a(CHEBI:"bafilomycin A1") increases p(HGNC:MAP1LC3B) + + + + + + + pubmed:26702100 + + a(CHEBI:"bafilomycin A1") increases a(GO:autophagosome) + + + + + + + pubmed:30145931 + + a(CHEBI:epoxomicin) decreases act(p(FPLX:Proteasome)) + + + + + + + pubmed:23528736 + + a(CHEBI:epoxomicin) decreases act(p(FPLX:Proteasome)) + + + + + + + + + pubmed:30145931 + + a(CHEBI:epoxomicin) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262), pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) + + + + + + + pubmed:30145931 + + a(CHEBI:epoxomicin) causesNoChange p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) + + + + + + + pubmed:24027553 + + a(CHEBI:epoxomicin) increases act(p(HGNC:CASP3)) + + + + + + + pubmed:24027553 + + a(CHEBI:epoxomicin) decreases deg(p(HGNC:MAPT)) + + + + + + + pubmed:24027553 + + a(CHEBI:epoxomicin) increases p(HGNC:MAPT) + + + + + + + pubmed:23528736 + + a(CHEBI:epoxomicin) decreases deg(p(HGNC:MAPT)) + + + + + + + pubmed:30145931 + + composite(a(CHEBI:epoxomicin), p(HGNC:MAPT)) increases bp(GO:"protein ubiquitination") + + + + + + + pubmed:30145931 + + composite(a(CHEBI:epoxomicin), p(HGNC:MAPT)) decreases a(MESH:"Dendritic Spines") + + + + + + + pubmed:30145931 + + a(CHEBI:rolipram) increases act(p(FPLX:Proteasome)) + + + + + + + pubmed:30145931 + + a(CHEBI:rolipram) decreases p(HGNC:MAPT, loc(MESH:Dendrites)) + + + + + + + pubmed:29626319 + + a(CHEBI:rolipram) increases deg(p(HGNC:MAPT)) + + + + + + + pubmed:29626319 + + a(CHEBI:rolipram) increases a(CHEBI:"3',5'-cyclic AMP") + + + + + + + pubmed:26692334 + + a(CHEBI:rolipram) increases a(CHEBI:"3',5'-cyclic AMP") + + + + + + + pubmed:26692334 + + a(CHEBI:rolipram) directlyDecreases act(p(FPLX:PDE4)) + + + + + + + pubmed:26692334 + + a(CHEBI:rolipram) increases act(p(FPLX:PKA)) + + + + + + + pubmed:26692334 + + a(CHEBI:rolipram) increases act(complex(GO:"proteasome complex")) + + + + + + + pubmed:26692334 + + a(CHEBI:rolipram) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:26692334 + + a(CHEBI:rolipram) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 214)) + + + + + + + pubmed:30145931 + + composite(a(CHEBI:wortmannin), p(HGNC:MAPT)) decreases a(MESH:"Dendritic Spines") + + + + + + + pubmed:30145931 + + a(CHEBI:cycloheximide) decreases bp(GO:translation) + + + + + + + pubmed:30145931 + + a(CHEBI:cycloheximide) decreases p(HGNC:MAPT, loc(MESH:Dendrites)) + + + + + + + pubmed:23702978 + + a(CHEBI:cycloheximide) increases bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") + + + + + + + pubmed:30145931 + + a(CHEBI:"(-)-anisomycin") decreases bp(GO:translation) + + + + + + + pubmed:30145931 + + a(CHEBI:"(-)-anisomycin") decreases p(HGNC:MAPT, loc(MESH:Dendrites)) + + + + + + + pubmed:22072628 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 235)) partOf p(CONSO:"proline-rich region 2", pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:26996941 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 235)) association act(p(HGNC:PIN1)) + + + + + + + + + + + + + + + + + + + + + + + + + + + + + pubmed:8282104 + + p(CONSO:CONSO00172) directlyIncreases p(CONSO:CONSO00053, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + + + pubmed:8282104 + + complex(p(CONSO:CONSO00172), p(HGNC:CDK5)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:8282104 + + a(CONSO:CONSO00006) association p(HGNC:CDK5) + + + + + + + pubmed:8282104 + + a(CONSO:CONSO00006) association p(HGNC:PRKACA) + + + + + + + pubmed:8282104 + + a(CONSO:CONSO00006) association p(FPLX:ERK) + + + + + + + pubmed:8282104 + + a(CONSO:CONSO00006) association p(FPLX:GSK3) + + + + + + + + + + + pubmed:27594586 + + g(DBSNP:rs63751011) increases p(HGNC:MAP2) + + + + + + + pubmed:27594586 + + g(DBSNP:rs63751011) causesNoChange a(GO:"symmetric, GABA-ergic, inhibitory synapse") + + + + + + + pubmed:27594586 + + g(DBSNP:rs63751011) causesNoChange p(HGNC:SLC17A7) + + + + + + + pubmed:27594586 + + g(DBSNP:rs63751011) causesNoChange p(HGNC:MAPT) + + + + + + + pubmed:27594586 + + g(DBSNP:rs63751011) causesNoChange p(HGNC:DLGAP4) + + + + + + + pubmed:27594586 + + g(DBSNP:rs63751011) causesNoChange bp(MESH:"Membrane Potentials") + + + + + + + pubmed:27594586 + + g(DBSNP:rs63751011) causesNoChange bp(GO:"neuron differentiation") + + + + + + + pubmed:27594586 + + g(DBSNP:rs63751011) increases act(p(HGNC:MMP9)) + + + + + + + pubmed:27594586 + + g(DBSNP:rs63751011) increases tloc(p(HGNC:MMP9), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:27594586 + + g(DBSNP:rs63751011) increases r(HGNC:MMP9) + + + + + + + pubmed:27594586 + + g(DBSNP:rs63751011) increases r(HGNC:MMP9) + + + + + + + pubmed:27594586 + + g(DBSNP:rs63751011) increases r(HGNC:MMP2) + + + + + + + pubmed:27594586 + + g(DBSNP:rs63751011) increases r(HGNC:MMP2) + + + + + + + pubmed:27594586 + + g(DBSNP:rs63751011) increases bp(GO:"neuron death") + + + + + + + pubmed:27594586 + + g(DBSNP:rs63751011) increases p(CONSO:CONSO00045) + + + + + + + pubmed:27594586 + + g(DBSNP:rs63751011) decreases p(CONSO:CONSO00044) + + + + + + + pubmed:27594586 + + path(MESH:"Neurodevelopmental Disorders") association act(p(HGNC:MMP9)) + + + + + + + pubmed:27594586 + + a(CHEBI:staurosporine) increases bp(GO:"apoptotic process") + + + + + + + + + pubmed:8726973 + + a(CHEBI:staurosporine) decreases act(p(HGNC:CDK5)) + + + + + + + pubmed:23666762 + + a(CHEBI:staurosporine) decreases complex(p(HGNC:MAPT), p(HGNC:MARK1)) + + + + + + + pubmed:23666762 + + a(CHEBI:staurosporine) decreases complex(p(HGNC:MAPT), p(HGNC:MARK2)) + + + + + + + pubmed:23001711 + + a(CHEBI:staurosporine) decreases complex(p(HGNC:MAPT), p(HGNC:MARK2)) + + + + + + + pubmed:23666762 + + a(CHEBI:staurosporine) decreases complex(p(HGNC:MAPT), p(HGNC:MARK3)) + + + + + + + pubmed:23666762 + + a(CHEBI:staurosporine) decreases complex(p(HGNC:MAPT), p(HGNC:MARK4)) + + + + + + + pubmed:23001711 + + a(CHEBI:staurosporine) decreases act(p(HGNC:MARK2), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:23001711 + + a(CHEBI:staurosporine) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) + + + + + + + pubmed:27594586 + + a(CHEBI:rotenone) increases path(CONSO:CONSO00037) + + + + + + + + + pubmed:27594586 + + composite(a(CHEBI:rotenone), p(HGNC:MAPT, var("p.Ala152Thr"))) causesNoChange bp(GO:"neuron death") + + + + + + + pubmed:27594586 + + composite(a(CHEBI:staurosporine), p(HGNC:MAPT, var("p.Ala152Thr"))) causesNoChange bp(GO:"neuron death") + + + + + + + pubmed:27594586 + + a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") decreases p(FPLX:ERK, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:27594586 + + a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") decreases tloc(p(HGNC:MMP9), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:27594586 + + a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") decreases act(p(HGNC:MMP9)) + + + + + + + pubmed:27594586 + + a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") causesNoChange act(p(HGNC:MMP2)) + + + + + + + pubmed:27594586 + + a(CHEBI:"2-(2-amino-3-methoxyphenyl)chromen-4-one") causesNoChange p(HGNC:MMP2) + + + + + + + + + + + pubmed:27594586 + + p(CONSO:CONSO00045, var("p.Ala152Thr")) increases tloc(p(HGNC:MMP9), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:27594586 + + p(CONSO:CONSO00045, var("p.Ala152Thr")) increases act(p(HGNC:MMP9)) + + + + + + + pubmed:27594586 + + p(CONSO:CONSO00045, var("p.Ala152Thr")) increases tloc(p(HGNC:MMP9), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:27594586 + + p(CONSO:CONSO00045, var("p.Ala152Thr")) increases act(p(HGNC:MMP9)) + + + + + + + pubmed:27594586 + + p(CONSO:CONSO00045, var("p.Ala152Thr")) increases r(HGNC:MMP9) + + + + + + + pubmed:27594586 + + p(CONSO:CONSO00045, var("p.Ala152Thr")) increases p(FPLX:ERK, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:27594586 + + p(CONSO:CONSO00045, var("p.Ala152Thr")) increases bp(GO:"ERK1 and ERK2 cascade") + + + + + + + pubmed:27594586 + + p(CONSO:CONSO00045, var("p.Ala152Thr")) increases tloc(p(HGNC:MMP2), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:27594586 + + p(CONSO:CONSO00045, var("p.Ala152Thr")) increases act(p(HGNC:MMP2)) + + + + + + + pubmed:27594586 + + p(CONSO:CONSO00044, var("p.Ala152Thr")) causesNoChange tloc(p(HGNC:MMP9), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:27594586 + + p(CONSO:CONSO00044, var("p.Ala152Thr")) causesNoChange act(p(HGNC:MMP9)) + + + + + + + pubmed:27594586 + + p(CONSO:CONSO00044, var("p.Ala152Thr")) causesNoChange p(FPLX:ERK, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:30116051 + + composite(a(CHEBI:"NAD(+)"), p(HGNC:SIRT1)) increases bp(GO:macroautophagy) + + + + + + + pubmed:30116051 + + p(HGNC:ULK1, pmod(go:0006468 ! "protein phosphorylation", Ser, 317)) increases act(p(HGNC:ULK1)) + + + + + + + pubmed:30116051 + + p(HGNC:ULK1, pmod(go:0006468 ! "protein phosphorylation", Ser, 777)) increases act(p(HGNC:ULK1)) + + + + + + + pubmed:30116051 + + p(FPLX:mTORC1, pmod(go:0006468 ! "protein phosphorylation")) decreases act(p(FPLX:mTORC1)) + + + + + + + pubmed:30116051 + + p(HGNC:ULK1, pmod(go:0006468 ! "protein phosphorylation", Ser, 757)) decreases act(p(HGNC:ULK1)) + + + + + + + pubmed:30116051 + + p(HGNC:AMBRA1, pmod(go:0006468 ! "protein phosphorylation")) increases act(p(HGNC:AMBRA1)) + + + + + + + + + pubmed:30116051 + + act(p(HGNC:AMBRA1)) increases bp(GO:"autophagosome assembly") + + + + + + + pubmed:30116051 + + p(HGNC:LGMN) increases p(HGNC:MAPT, frag("?")) + + + + + + + pubmed:30116051 + + act(complex(GO:"lysosomal proton-transporting V-type ATPase complex")) negativeCorrelation g(HGNC:PSEN1, var("?")) + + + + + + + pubmed:30116051 + + p(HGNC:GBA, var("?")) increases path(MESH:"Gaucher Disease") + + + + + + + pubmed:30116051 + + p(HGNC:GBA, var("?")) decreases bp(GO:macroautophagy) + + + + + + + pubmed:30116051 + + p(HGNC:GBA, var("?")) increases p(HGNC:SNCA) + + + + + + + pubmed:30116051 + + p(HGNC:GBA, var("?")) increases path(MESH:"Parkinson Disease") + + + + + + + pubmed:30116051 + + p(HGNC:C9orf72) association path(MESH:"Frontotemporal Dementia") + + + + + + + + + pubmed:30837838 + + p(HGNC:C9orf72) association path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:30116051 + + p(HGNC:CHMP2B) association path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:30116051 + + p(HGNC:TBK1) association path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:30837838 + + p(HGNC:TBK1) association path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + + + pubmed:27181519 + + p(HGNC:TBK1) association path(MESH:"Liver Diseases") + + + + + + + pubmed:27181519 + + p(HGNC:TBK1) association path(CONSO:Neurodegeneration) + + + + + + + pubmed:27181519 + + p(HGNC:TBK1) association path(DOID:"amyotrophic lateral sclerosis") + + + + + + + pubmed:27181519 + + p(HGNC:TBK1) increases path(DOID:"amyotrophic lateral sclerosis") + + + + + + + pubmed:27181519 + + p(HGNC:TBK1) increases p(HGNC:OPTN, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + + + pubmed:30116051 + + p(HGNC:OPTN, var("?")) decreases bp(GO:"cargo loading into vesicle") + + + + + + + pubmed:27181519 + + p(HGNC:OPTN, var("?")) association path(DOID:"amyotrophic lateral sclerosis") + + + + + + + pubmed:30116051 + + p(HGNC:TBK1, var("?")) decreases bp(GO:"cargo loading into vesicle") + + + + + + + pubmed:30116051 + + p(HGNC:C9orf72, var("?")) decreases bp(GO:autophagy) + + + + + + + pubmed:30116051 + + a(CHEBI:clonidine) increases bp(GO:autophagy) + + + + + + + pubmed:30116051 + + a(CHEBI:clonidine) increases deg(p(HGNC:HTT)) + + + + + + + pubmed:30116051 + + a(CHEBI:Rilmenidine) increases bp(GO:autophagy) + + + + + + + pubmed:30116051 + + a(CHEBI:Rilmenidine) increases deg(p(HGNC:HTT)) + + + + + + + pubmed:30116051 + + p(HGNC:CAST) decreases act(p(HGNC:CAPN1)) + + + + + + + pubmed:30116051 + + p(HGNC:CAST) decreases act(p(HGNC:CAPN2)) + + + + + + + pubmed:30116051 + + p(HGNC:CAST) increases bp(GO:autophagy) + + + + + + + pubmed:30116051 + + p(HGNC:CAST) increases deg(p(HGNC:HTT, var("?"))) + + + + + + + pubmed:30116051 + + p(HGNC:CAST) increases deg(p(HGNC:MAPT)) + + + + + + + pubmed:30116051 + + p(HGNC:CAST) increases deg(p(HGNC:SNCA)) + + + + + + + pubmed:30116051 + + p(HGNC:CAST) increases deg(p(HGNC:SOD1)) + + + + + + + pubmed:30116051 + + a(CHEBI:Calpeptin) decreases act(p(HGNC:CAPN1)) + + + + + + + pubmed:30116051 + + a(CHEBI:Calpeptin) decreases act(p(HGNC:CAPN2)) + + + + + + + pubmed:30116051 + + a(CHEBI:Calpeptin) increases bp(GO:autophagy) + + + + + + + pubmed:30116051 + + a(CHEBI:Calpeptin) increases deg(p(HGNC:HTT, var("?"))) + + + + + + + pubmed:30116051 + + a(CHEBI:"AICA ribonucleotide") increases act(p(FPLX:AMPK)) + + + + + + + pubmed:22419736 + + a(CHEBI:"AICA ribonucleotide") increases act(p(FPLX:AMPK)) + + + + + + + pubmed:22419736 + + a(CHEBI:"AICA ribonucleotide") increases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) + + + + + + + pubmed:22419736 + + a(CHEBI:"AICA ribonucleotide") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) + + + + + + + pubmed:22419736 + + a(CHEBI:"AICA ribonucleotide") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + + + + + + + pubmed:30116051 + + a(PUBCHEM:54708532) increases act(p(FPLX:AMPK)) + + + + + + + pubmed:30116051 + + a(PUBCHEM:54708532) increases deg(p(HGNC:HTT, var("?"))) + + + + + + + pubmed:30116051 + + a(PUBCHEM:54708532) increases bp(GO:macroautophagy) + + + + + + + pubmed:30116051 + + a(CHEBI:"selenium(2+)") negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:30116051 + + a(CHEBI:selenomethionine) increases bp(GO:autophagy) + + + + + + + pubmed:30116051 + + a(CHEBI:selenomethionine) increases act(p(FPLX:AMPK)) + + + + + + + pubmed:30116051 + + a(CHEBI:selenomethionine) increases bp(GO:"autophagosome assembly") + + + + + + + pubmed:30116051 + + a(CHEBI:selenomethionine) increases bp(GO:"lysosomal microautophagy") + + + + + + + pubmed:30116051 + + composite(a(CHEBI:"calcium(2+)"), p(HGNC:CAMKK2)) increases p(FPLX:AMPK, pmod(go:0006468 ! "protein phosphorylation", Thr, 172)) + + + + + + + pubmed:22419736 + + p(FPLX:AMPK, pmod(go:0006468 ! "protein phosphorylation", Thr, 172)) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:22419736 + + p(FPLX:AMPK, pmod(go:0006468 ! "protein phosphorylation", Thr, 172)) negativeCorrelation p(HGNC:AK1) + + + + + + + pubmed:30116051 + + a(CHEBI:calcitriol) increases act(p(FPLX:AMPK)) + + + + + + + pubmed:30116051 + + a(CHEBI:calcitriol) increases bp(GO:macroautophagy) + + + + + + + pubmed:29626319 + + act(a(CHEBI:calcitriol)) increases tloc(a(CHEBI:"amyloid-beta polypeptide 40"), fromLoc(MESH:Brain), toLoc(MESH:Blood)) + + + + + + + pubmed:29626319 + + a(CHEBI:calcitriol) decreases p(HGNC:AGER) + + + + + + + pubmed:29626319 + + a(CHEBI:calcitriol) increases p(HGNC:LRP1) + + + + + + + pubmed:30116051 + + complex(a(CHEBI:sirolimus), p(HGNC:FKBP1A)) decreases act(p(FPLX:mTORC1)) + + + + + + + + + pubmed:23832849 + + p(HGNC:FKBP1A) association a(GO:"neurofibrillary tangle") + + + + + + + pubmed:23832849 + + p(HGNC:FKBP1A) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:23832849 + + p(HGNC:FKBP1A) decreases a(CONSO:"Tau oligomers") + + + + + + + pubmed:30116051 + + a(CHEBI:fisetin) increases bp(GO:macroautophagy) + + + + + + + pubmed:30116051 + + a(CHEBI:fisetin) increases act(p(FPLX:mTORC1)) + + + + + + + pubmed:30116051 + + a(CHEBI:fisetin) decreases a(CHEBI:amyloid-beta) + + + + + + + pubmed:30116051 + + a(CHEBI:nilotinib) decreases act(p(HGNC:ABL1)) + + + + + + + pubmed:30116051 + + a(CHEBI:nilotinib) increases bp(GO:macroautophagy) + + + + + + + pubmed:30116051 + + a(CHEBI:nilotinib) decreases bp(HP:Neurodegeneration) + + + + + + + pubmed:30116051 + + a(CHEBI:cilostazol) decreases a(CHEBI:"amyloid-beta polypeptide 42") + + + + + + + pubmed:30116051 + + a(CHEBI:cilostazol) increases bp(GO:macroautophagy) + + + + + + + pubmed:30116051 + + a(CHEBI:cilostazol) increases act(p(HGNC:BECN1)) + + + + + + + pubmed:30116051 + + a(CHEBI:cilostazol) increases act(p(HGNC:ATG5)) + + + + + + + pubmed:30116051 + + a(CHEBI:cilostazol) increases act(p(HGNC:MAP1LC3A)) + + + + + + + pubmed:30116051 + + a(CHEBI:cilostazol) decreases act(p(FPLX:mTORC1)) + + + + + + + pubmed:30116051 + + a(CHEBI:cilostazol) increases p(HGNC:CTSB) + + + + + + + pubmed:30116051 + + a(CHEBI:cilostazol) increases act(p(HGNC:SIRT1)) + + + + + + + pubmed:30116051 + + a(CHEBI:cilostazol) increases p(FPLX:AMPK, pmod(go:0006468 ! "protein phosphorylation", Tyr, 172)) + + + + + + + + + pubmed:30116051 + + composite(a(CHEBI:cilostazol), a(MESH:"amyloid beta-protein (25-35)")) increases bp(GO:cognition) + + + + + + + pubmed:30116051 + + composite(a(CHEBI:cilostazol), a(MESH:"amyloid beta-protein (25-35)")) decreases a(CHEBI:"amyloid-beta polypeptide 42") + + + + + + + pubmed:30116051 + + composite(a(CHEBI:cilostazol), a(MESH:"amyloid beta-protein (25-35)")) decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) + + + + + + + + + pubmed:30116051 + + a(CHEBI:Isorhynchophylline) increases act(p(HGNC:BECN1)) + + + + + + + pubmed:30116051 + + a(CHEBI:Isorhynchophylline) increases deg(p(HGNC:SNCA)) + + + + + + + pubmed:30116051 + + a(CHEBI:Isorhynchophylline) increases bp(GO:macroautophagy) + + + + + + + pubmed:30116051 + + complex(p(HGNC:BCL2), p(HGNC:BECN1)) decreases bp(GO:macroautophagy) + + + + + + + pubmed:30116051 + + a(PUBCHEM:16240819) decreases act(p(HGNC:MTMR14)) + + + + + + + pubmed:30116051 + + a(PUBCHEM:16240819) increases bp(GO:macroautophagy) + + + + + + + pubmed:30116051 + + a(PUBCHEM:16240819) decreases bp(HP:Neurodegeneration) + + + + + + + pubmed:30116051 + + p(HGNC:MTMR14) decreases act(p(FPLX:PI3K)) + + + + + + + pubmed:30116051 + + a(CHEBI:"epothilone A") increases a(GO:microtubule) + + + + + + + pubmed:30116051 + + a(PUBCHEM:129688311) increases bp(GO:"lysosomal lumen acidification") + + + + + + + pubmed:30116051 + + a(PUBCHEM:129688311) decreases p(HGNC:SNCA) + + + + + + + pubmed:30116051 + + a(PUBCHEM:129688311) decreases a(CHEBI:amyloid-beta) + + + + + + + pubmed:30116051 + + a(CHEBI:"poly(lactic acid) polymer") increases bp(GO:"lysosomal lumen acidification") + + + + + + + pubmed:30116051 + + a(CHEBI:"poly(D,L-lactic acid-co-glycolic acid)") increases bp(GO:"lysosomal lumen acidification") + + + + + + + pubmed:30116051 + + a(PUBCHEM:2880983) increases act(p(HGNC:MCOLN1)) + + + + + + + pubmed:30116051 + + a(CHEBI:chlorohydroquinone) decreases bp(GO:macroautophagy) + + + + + + + pubmed:30116051 + + a(CHEBI:ambroxol) increases p(HGNC:GBA) + + + + + + + pubmed:30116051 + + a(CHEBI:ambroxol) increases bp(GO:macroautophagy) + + + + + + + pubmed:30116051 + + a(CHEBI:ambroxol) increases deg(p(HGNC:SNCA)) + + + + + + + pubmed:30116051 + + a(CHEBI:ambroxol) decreases p(HGNC:SNCA) + + + + + + + pubmed:30116051 + + a(CHEBI:ambroxol) decreases bp(GO:"response to endoplasmic reticulum stress") + + + + + + + pubmed:30116051 + + a(PUBCHEM:9568077) increases act(p(HGNC:HSF1), ma(go:0001071 ! "nucleic acid binding transcription factor activity")) + + + + + + + pubmed:30837838 + + a(PUBCHEM:9568077) increases act(p(HGNC:HSF1)) + + + + + + + pubmed:30837838 + + a(PUBCHEM:9568077) decreases p(CONSO:"TDP-43 aggregates") + + + + + + + pubmed:30116051 + + a(PUBCHEM:46216556) decreases act(p(FPLX:HSP90)) + + + + + + + pubmed:30116051 + + a(PUBCHEM:46216556) decreases a(CONSO:"huntingtin aggregates") + + + + + + + pubmed:30116051 + + a(PUBCHEM:46216556) increases path(MESH:"Motor Activity") + + + + + + + pubmed:30116051 + + a(PUBCHEM:3086599) increases act(complex(GO:"proteasome complex")) + + + + + + + pubmed:30116051 + + a(PUBCHEM:3086599) increases act(p(FPLX:PKA), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:30116051 + + p(HGNC:PSMC5, pmod(go:0006468 ! "protein phosphorylation", Ser, 120)) increases act(complex(GO:"proteasome complex")) + + + + + + + + + pubmed:30116051 + + complex(p(HGNC:BIRC2), p(HGNC:SOD1)) increases deg(p(HGNC:SOD1)) + + + + + + + + + pubmed:23702978 + + p(HGNC:BIRC2) decreases complex(GO:ripoptosome) + + + + + + + pubmed:30116051 + + p(HGNC:PLG) increases deg(a(CHEBI:"amyloid-beta polypeptide 42")) + + + + + + + pubmed:30116051 + + p(HGNC:PLG) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:30116051 + + p(HGNC:PLG) increases deg(p(HGNC:SNCA)) + + + + + + + pubmed:26195256 + + p(HGNC:PLG) increases deg(a(CHEBI:amyloid-beta, loc(GO:"extracellular region"))) + + + + + + + pubmed:30116051 + + p(HGNC:KLK6) increases p(HGNC:SNCA, frag("?")) + + + + + + + pubmed:30116051 + + a(CHEBI:"(-)-epigallocatechin") increases p(HGNC:IDE) + + + + + + + pubmed:30116051 + + a(CHEBI:"(-)-epigallocatechin") increases tloc(p(HGNC:IDE), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:30116051 + + a(CHEBI:"(-)-epigallocatechin") increases act(p(HGNC:IDE)) + + + + + + + pubmed:30116051 + + a(CHEBI:"(-)-epigallocatechin") increases p(HGNC:MME) + + + + + + + pubmed:30116051 + + a(CHEBI:"(-)-epigallocatechin") increases tloc(p(HGNC:MME), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:30116051 + + a(CHEBI:"(-)-epigallocatechin") increases act(p(HGNC:MME)) + + + + + + + pubmed:30116051 + + a(CHEBI:somatostatin) increases p(HGNC:IDE) + + + + + + + pubmed:30116051 + + a(CHEBI:somatostatin) increases tloc(p(HGNC:IDE), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:30116051 + + a(CHEBI:somatostatin) increases act(p(HGNC:IDE)) + + + + + + + pubmed:29626319 + + a(CHEBI:somatostatin) increases p(HGNC:IDE) + + + + + + + pubmed:30116051 + + a(CHEBI:somatostatin) increases p(HGNC:MME) + + + + + + + pubmed:30116051 + + a(CHEBI:somatostatin) increases tloc(p(HGNC:MME), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:30116051 + + a(CHEBI:somatostatin) increases act(p(HGNC:MME)) + + + + + + + pubmed:29626319 + + a(CHEBI:somatostatin) increases deg(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:30116051 + + a(CHEBI:rifampicin) increases deg(a(CHEBI:"amyloid-beta polypeptide 42")) + + + + + + + pubmed:30116051 + + a(CHEBI:rifampicin) increases act(p(HGNC:LRP1)) + + + + + + + pubmed:30116051 + + a(CHEBI:rifampicin) increases act(p(FPLX:"GPIb_IX_V")) + + + + + + + pubmed:23484434 + + a(CHEBI:6872) decreases a(CONSO:CONSO00006) + + + + + + + pubmed:23484434 + + a(CHEBI:8028) causesNoChange a(CONSO:CONSO00006) + + + + + + + pubmed:23484434 + + a(CHEBI:44932) causesNoChange a(CONSO:CONSO00006) + + + + + + + pubmed:23484434 + + a(CHEBI:3647) causesNoChange a(CONSO:CONSO00006) + + + + + + + pubmed:23484434 + + a(CHEBI:87637) decreases a(CONSO:CONSO00006) + + + + + + + pubmed:23484434 + + a(CHEBI:22580) decreases a(CONSO:CONSO00006) + + + + + + + pubmed:23484434 + + a(CHEBI:1457) decreases a(CONSO:CONSO00018) + + + + + + + pubmed:23484434 + + a(CHEBI:10642) decreases a(CONSO:CONSO00018) + + + + + + + pubmed:23484434 + + a(CHEBI:4806) decreases a(CONSO:CONSO00018) + + + + + + + pubmed:23484434 + + a(CHEBI:4806) decreases a(CONSO:CONSO00006) + + + + + + + pubmed:23484434 + + a(CHEBI:74460) decreases a(CONSO:CONSO00018) + + + + + + + pubmed:23484434 + + a(CONSO:CONSO00021) decreases a(CONSO:CONSO00018) + + + + + + + pubmed:23484434 + + a(CONSO:CONSO00019) decreases a(CONSO:CONSO00018) + + + + + + + pubmed:23484434 + + a(CHEBI:90) causesNoChange a(CONSO:CONSO00006) + + + + + + + pubmed:23484434 + + a(CHEBI:18152) decreases a(CONSO:CONSO00006) + + + + + + + pubmed:23484434 + + a(CHEBI:3441) decreases a(CONSO:CONSO00018) + + + + + + + pubmed:23484434 + + a(CHEBI:3441) decreases a(CONSO:CONSO00006) + + + + + + + pubmed:23484434 + + a(CHEBI:6710) decreases a(CONSO:CONSO00006) + + + + + + + pubmed:23484434 + + a(CHEBI:6710) decreases a(CONSO:CONSO00018) + + + + + + + + + pubmed:23484434 + + a(CHEBI:76034) increases complex(a(CHEBI:76034), a(GO:"GO:0097418")) + + + + + + + pubmed:23484434 + + a(CHEBI:76034) decreases a(CONSO:CONSO00006) + + + + + + + + + pubmed:23484434 + + a(CHEBI:112284) decreases a(CONSO:CONSO00006) + + + + + + + pubmed:23484434 + + a(CONSO:CONSO00020) decreases a(CONSO:CONSO00006) + + + + + + + pubmed:29024336 + + path(MESH:"Proteostasis Deficiencies") decreases deg(p(MGI:Mapt, var("p.Pro301Leu"))) + + + + + + + pubmed:29024336 + + bp(GO:"late endosomal microautophagy") increases deg(p(MGI:Mapt)) + + + + + + + pubmed:29024336 + + bp(GO:"late endosomal microautophagy") increases deg(p(MGI:Mapt)) + + + + + + + pubmed:29024336 + + bp(GO:"late endosomal microautophagy") increases deg(p(CONSO:CONSO00053)) + + + + + + + pubmed:29024336 + + p(MGI:Mapt, var("p.Pro301Leu")) decreases deg(p(MGI:Mapt)) + + + + + + + pubmed:29024336 + + p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Mapt) + + + + + + + pubmed:29024336 + + p(MGI:Mapt, var("p.Pro301Leu")) decreases deg(p(MGI:Mapt)) + + + + + + + pubmed:29024336 + + p(MGI:Mapt, var("p.Pro301Leu")) decreases deg(p(MGI:Mapt)) + + + + + + + pubmed:29024336 + + p(MGI:Mapt, var("p.Pro301Leu")) decreases deg(p(MGI:Mapt)) + + + + + + + pubmed:29024336 + + p(MGI:Mapt, var("p.Pro301Leu")) increases a(CONSO:CONSO00006) + + + + + + + pubmed:29024336 + + p(MGI:Mapt, var("p.Pro301Leu")) increases a(CONSO:CONSO00100) + + + + + + + pubmed:29024336 + + p(MGI:Mapt, var("p.Pro301Leu")) decreases complex(a(GO:lysosome), p(MGI:Mapt)) + + + + + + + pubmed:29024336 + + p(MGI:Mapt, var("p.Pro301Leu")) decreases complex(a(GO:lysosome), p(MGI:Mapt)) + + + + + + + + + pubmed:29024336 + + p(MGI:Mapt, var("p.Pro301Leu")) decreases bp(GO:"late endosomal microautophagy") + + + + + + + pubmed:29024336 + + p(MGI:Mapt, var("p.Pro301Leu")) decreases deg(p(MGI:Mapt, var("p.Pro301Leu"))) + + + + + + + pubmed:29024336 + + p(MGI:Mapt, var("p.Pro301Leu")) increases deg(a(MESH:Proteins)) + + + + + + + pubmed:29024336 + + p(MGI:Mapt, var("p.Pro301Leu")) increases deg(a(MESH:Proteins)) + + + + + + + pubmed:29024336 + + p(MGI:Mapt, var("p.Pro301Leu")) increases bp(GO:"chaperone-mediated autophagy") + + + + + + + + + + + pubmed:29024336 + + p(MGI:Mapt, var("p.Pro301Leu")) increases a(GO:autophagosome) + + + + + + + pubmed:29024336 + + p(MGI:Mapt, var("p.Pro301Leu")) increases a(GO:autolysosome) + + + + + + + pubmed:29024336 + + p(MGI:Mapt, var("p.Pro301Leu")) increases bp(GO:macroautophagy) + + + + + + + pubmed:29024336 + + p(MGI:Mapt, var("p.Pro301Leu")) increases bp(GO:macroautophagy) + + + + + + + pubmed:24027553 + + p(MGI:Mapt, var("p.Pro301Leu")) increases path(CONSO:Neurodegeneration) + + + + + + + pubmed:24027553 + + p(MGI:Mapt, var("p.Pro301Leu")) positiveCorrelation p(HGNC:NPEPPS) + + + + + + + pubmed:30126037 + + p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:H2afx) + + + + + + + pubmed:30126037 + + p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Cdkn1a) + + + + + + + pubmed:30126037 + + p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Cdkn2a) + + + + + + + pubmed:30126037 + + p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Il1b) + + + + + + + pubmed:30126037 + + p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Cxcl1) + + + + + + + pubmed:30126037 + + p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Tnf) + + + + + + + pubmed:30126037 + + p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Tlr4) + + + + + + + pubmed:30126037 + + p(MGI:Mapt, var("p.Pro301Leu")) increases bp(GO:"NIK/NF-kappaB signaling") + + + + + + + pubmed:30126037 + + p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Rela) + + + + + + + pubmed:30126037 + + p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Glb1) + + + + + + + pubmed:30126037 + + p(MGI:Mapt, var("p.Pro301Leu")) increases path(MESH:Tauopathies) + + + + + + + pubmed:30126037 + + p(MGI:Mapt, var("p.Pro301Leu")) increases a(GO:"neurofibrillary tangle") + + + + + + + pubmed:30126037 + + p(MGI:Mapt, var("p.Pro301Leu")) increases bp(GO:"cellular senescence") + + + + + + + pubmed:30126037 + + p(MGI:Mapt, var("p.Pro301Leu")) association bp(MESH:"Cerebrovascular Circulation") + + + + + + + pubmed:30126037 + + p(MGI:Mapt, var("p.Pro301Leu")) increases bp(MESH:"Cerebrovascular Circulation") + + + + + + + pubmed:29121589 + + p(MGI:Mapt, var("p.Pro301Leu")) increases path(CONSO:Astrogliosis) + + + + + + + pubmed:29121589 + + p(MGI:Mapt, var("p.Pro301Leu")) increases path(CONSO:Microgliosis) + + + + + + + pubmed:29024336 + + p(MGI:Mapt, var("p.Ala152Thr")) decreases deg(p(MGI:Mapt)) + + + + + + + pubmed:29024336 + + p(MGI:Mapt, var("p.Ala152Thr")) increases p(MGI:Mapt) + + + + + + + pubmed:29024336 + + p(MGI:Mapt, var("p.Ala152Thr")) decreases deg(p(MGI:Mapt)) + + + + + + + pubmed:29024336 + + p(MGI:Mapt, var("p.Ala152Thr")) decreases deg(p(MGI:Mapt)) + + + + + + + pubmed:29024336 + + p(MGI:Mapt, var("p.Ala152Thr")) increases a(CONSO:CONSO00009) + + + + + + + + + pubmed:29024336 + + p(MGI:Mapt, var("p.Ala152Thr")) decreases bp(GO:"late endosomal microautophagy") + + + + + + + pubmed:29024336 + + p(MGI:Mapt, var("p.Ala152Thr")) decreases bp(GO:"late endosomal microautophagy") + + + + + + + pubmed:29024336 + + p(MGI:Mapt, var("p.Ala152Thr")) decreases deg(p(MGI:Mapt, var("p.Ala152Thr"))) + + + + + + + pubmed:29024336 + + p(MGI:Mapt, var("p.Ala152Thr")) increases deg(a(MESH:Proteins)) + + + + + + + pubmed:29024336 + + p(MGI:Mapt, var("p.Ala152Thr")) increases deg(a(MESH:Proteins)) + + + + + + + pubmed:29024336 + + p(MGI:Mapt, var("p.Ala152Thr")) increases deg(a(MESH:Proteins)) + + + + + + + pubmed:29024336 + + p(MGI:Mapt, var("p.Ala152Thr")) increases bp(GO:"chaperone-mediated autophagy") + + + + + + + + + + + pubmed:29024336 + + p(MGI:Mapt, var("p.Ala152Thr")) increases a(GO:autophagosome) + + + + + + + pubmed:29024336 + + p(MGI:Mapt, var("p.Ala152Thr")) increases a(GO:autolysosome) + + + + + + + pubmed:29024336 + + p(MGI:Mapt, var("p.Ala152Thr")) increases bp(GO:macroautophagy) + + + + + + + pubmed:29024336 + + p(MGI:Mapt, var("p.Ala152Thr")) increases bp(GO:macroautophagy) + + + + + + + pubmed:29024336 + + complex(a(GO:lysosome), p(MGI:Mapt, var("p.Pro301Leu"))) increases tloc(p(MGI:Mapt, var("p.Pro301Leu")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) + + + + + + + pubmed:29024336 + + complex(a(GO:lysosome), p(MGI:Snca, var("?"))) decreases tloc(p(MGI:Snca, var("?")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) + + + + + + + + + + + pubmed:29024336 + + complex(a(GO:lysosome), p(MGI:Lrrk2, var("?"))) decreases tloc(p(MGI:Lrrk2, var("?")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) + + + + + + + + + + + pubmed:29024336 + + a(CHEBI:paraquat) increases bp(GO:"response to oxidative stress") + + + + + + + + + + + + + pubmed:28019679 + + a(CHEBI:paraquat) increases act(complex(GO:"NLRP3 inflammasome complex")) + + + + + + + pubmed:28019679 + + a(CHEBI:paraquat) increases p(HGNC:CASP1) + + + + + + + pubmed:28019679 + + a(CHEBI:paraquat) increases p(HGNC:IL1B) + + + + + + + pubmed:29024336 + + composite(a(CHEBI:thapsigargin), p(CONSO:CONSO00053)) increases bp(GO:"chaperone-mediated autophagy") + + + + + + + pubmed:29024336 + + composite(a(CHEBI:paraquat), p(CONSO:CONSO00053)) increases bp(GO:"chaperone-mediated autophagy") + + + + + + + pubmed:29024336 + + composite(a(CHEBI:paraquat), p(MGI:Mapt, var("p.Pro301Leu"))) decreases bp(GO:"chaperone-mediated autophagy") + + + + + + + pubmed:29024336 + + composite(a(CHEBI:thapsigargin), p(MGI:Mapt, var("p.Pro301Leu"))) decreases bp(GO:"chaperone-mediated autophagy") + + + + + + + pubmed:29024336 + + composite(a(CHEBI:thapsigargin), p(MGI:Mapt, var("p.Ala152Thr"))) causesNoChange bp(GO:"chaperone-mediated autophagy") + + + + + + + pubmed:29024336 + + composite(a(CHEBI:paraquat), p(MGI:Mapt, var("p.Ala152Thr"))) causesNoChange bp(GO:"chaperone-mediated autophagy") + + + + + + + pubmed:29024336 + + composite(a(CHEBI:"ammonium chloride"), a(CHEBI:leupeptin)) decreases bp(GO:"late endosomal microautophagy") + + + + + + + + + pubmed:29024336 + + p(CONSO:CONSO00057) increases tloc(p(MGI:Mapt), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) + + + + + + + pubmed:29024336 + + p(CONSO:CONSO00057) increases bp(GO:"chaperone-mediated autophagy") + + + + + + + pubmed:29024336 + + p(CONSO:CONSO00055) increases tloc(p(MGI:Mapt), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) + + + + + + + pubmed:29024336 + + p(CONSO:CONSO00055) decreases deg(p(MGI:Mapt)) + + + + + + + pubmed:29024336 + + p(CONSO:CONSO00055) decreases bp(GO:"late endosomal microautophagy") + + + + + + + pubmed:29024336 + + p(CONSO:CONSO00054) decreases tloc(p(MGI:Mapt), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) + + + + + + + pubmed:29024336 + + p(CONSO:CONSO00053, var("p.Lys280del")) increases a(CONSO:CONSO00006) + + + + + + + pubmed:29024336 + + p(CONSO:CONSO00053, var("p.Lys280del")) decreases deg(p(HGNC:MAPT)) + + + + + + + pubmed:29024336 + + p(CONSO:CONSO00053, var("p.Lys280del")) decreases tloc(p(CONSO:CONSO00053, var("p.Lys280del")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) + + + + + + + pubmed:29024336 + + p(CONSO:CONSO00053, var("p.Lys280delinsProPro")) increases tloc(p(CONSO:CONSO00053, var("p.Lys280del")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) + + + + + + + pubmed:29024336 + + p(CONSO:CONSO00053, var("p.Lys280delinsProPro")) decreases a(CONSO:CONSO00006) + + + + + + + pubmed:29024336 + + p(CONSO:CONSO00053, var("p.Lys280delinsProPro")) decreases tloc(p(CONSO:CONSO00053, var("p.Lys280Pro")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) + + + + + + + pubmed:29024336 + + p(CONSO:CONSO00053, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) decreases tloc(p(CONSO:CONSO00053, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) + + + + + + + pubmed:29024336 + + p(CONSO:CONSO00053, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) decreases deg(p(CONSO:CONSO00053, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205))) + + + + + + + pubmed:29024336 + + p(CONSO:CONSO00053, pmod(go:0006468 ! "protein phosphorylation", Ser, 214), pmod(go:0006468 ! "protein phosphorylation", Thr, 212)) decreases tloc(p(CONSO:CONSO00053, pmod(go:0006468 ! "protein phosphorylation", Ser, 214), pmod(go:0006468 ! "protein phosphorylation", Thr, 212)), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) + + + + + + + pubmed:29024336 + + p(CONSO:CONSO00053, pmod(go:0006468 ! "protein phosphorylation", Ser, 214), pmod(go:0006468 ! "protein phosphorylation", Thr, 212)) decreases deg(p(CONSO:CONSO00053, pmod(go:0006468 ! "protein phosphorylation", Ser, 214), pmod(go:0006468 ! "protein phosphorylation", Thr, 212))) + + + + + + + pubmed:29024336 + + p(CONSO:CONSO00053, pmod(go:0006468 ! "protein phosphorylation", Ser, 396), pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) decreases tloc(p(CONSO:CONSO00053, pmod(go:0006468 ! "protein phosphorylation", Ser, 396), pmod(go:0006468 ! "protein phosphorylation", Ser, 404)), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) + + + + + + + pubmed:29024336 + + p(CONSO:CONSO00053, pmod(go:0006468 ! "protein phosphorylation", Ser, 396), pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) decreases deg(p(CONSO:CONSO00053, pmod(go:0006468 ! "protein phosphorylation", Ser, 396), pmod(go:0006468 ! "protein phosphorylation", Ser, 404))) + + + + + + + pubmed:29024336 + + p(CONSO:CONSO00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu")) decreases tloc(p(CONSO:CONSO00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) + + + + + + + pubmed:29024336 + + p(CONSO:CONSO00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu")) decreases deg(p(CONSO:CONSO00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu"))) + + + + + + + pubmed:29024336 + + p(CONSO:CONSO00053, var("p.Ser262Ala"), var("p.Ser293Ala"), var("p.Ser324Ala"), var("p.Ser356Ala")) increases tloc(p(CONSO:CONSO00053, var("p.Ser262Ala"), var("p.Ser293Ala"), var("p.Ser324Ala"), var("p.Ser356Ala")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome)) + + + + + + + pubmed:29215007 + + p(CONSO:CONSO00166) increases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) + + + + + + + pubmed:29215007 + + complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) positiveCorrelation p(CONSO:CONSO00169) + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + pubmed:29215007 + + composite(complex(GO:"filamentous actin"), p(HGNC:CFL1)) decreases complex(GO:"filamentous actin") + + + + + + + + + + + pubmed:24760868 + + complex(GO:"filamentous actin") association p(HGNC:MAPT) + + + + + + + pubmed:24760868 + + complex(GO:"filamentous actin") increases p(HGNC:MAPT) + + + + + + + pubmed:24760868 + + complex(GO:"filamentous actin") increases p(HGNC:MAPT, loc(GO:synapse)) + + + + + + + pubmed:19118186 + + complex(GO:"filamentous actin") negativeCorrelation complex(p(MGI:Cdk5), p(MGI:Cdk5r1)) + + + + + + + + + + + + + + + pubmed:29215007 + + p(CONSO:CONSO00169) positiveCorrelation complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) + + + + + + + pubmed:29215007 + + p(CONSO:CONSO00169) positiveCorrelation complex(a(GO:"filamentous actin"), p(HGNC:CFL1)) + + + + + + + pubmed:29215007 + + p(CONSO:CONSO00169) positiveCorrelation complex(a(MESH:Actins), p(HGNC:CFL1)) + + + + + + + + + pubmed:29215007 + + complex(a(GO:"filamentous actin"), p(HGNC:CFL1)) positiveCorrelation p(CONSO:CONSO00169) + + + + + + + pubmed:29215007 + + complex(a(MESH:Actins), p(HGNC:CFL1)) positiveCorrelation p(CONSO:CONSO00169) + + + + + + + pubmed:29215007 + + a(MESH:Endopeptidases) increases p(HGNC:MAPT, var("?")) + + + + + + + + + pubmed:29215007 + + p(HGNC:MAPT, frag("244_372")) increases bp(GO:"actin filament bundle assembly") + + + + + + + pubmed:29215007 + + p(HGNC:MAPT, frag("254_290")) increases bp(GO:"actin filament bundle assembly") + + + + + + + pubmed:29215007 + + p(HGNC:MAPT, frag("254_290")) increases bp(GO:"actin filament bundle assembly") + + + + + + + + + + + pubmed:29215007 + + p(HGNC:MAPT, frag("254_290")) increases complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_290"))) + + + + + + + pubmed:29215007 + + p(HGNC:MAPT, frag("260_268")) increases bp(MESH:"Protein Structure, Secondary") + + + + + + + + + pubmed:29215007 + + p(HGNC:MAPT, frag("277_283")) increases bp(MESH:"Protein Structure, Secondary") + + + + + + + pubmed:29215007 + + p(HGNC:MAPT, frag("277_283")) increases bp(MESH:"Protein Conformation, alpha-Helical") + + + + + + + + + pubmed:29215007 + + p(HGNC:MAPT, frag("261_268")) increases bp(MESH:"Protein Conformation, alpha-Helical") + + + + + + + + + pubmed:22072628 + + bp(MESH:"Protein Conformation, alpha-Helical") positiveCorrelation p(CONSO:"proline-rich region 2", pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:22072628 + + bp(MESH:"Protein Conformation, alpha-Helical") association p(HGNC:MAPT, frag("235_324")) + + + + + + + pubmed:29215007 + + p(HGNC:MAPT, frag("277_280")) increases p(CONSO:CONSO00170) + + + + + + + + + pubmed:29215007 + + p(HGNC:MAPT, frag("261_265")) increases p(CONSO:CONSO00170) + + + + + + + + + pubmed:29215007 + + complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("261_268"))) increases bp(MESH:"Protein Conformation, alpha-Helical") + + + + + + + pubmed:29215007 + + complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("277_280"))) increases p(CONSO:CONSO00170) + + + + + + + pubmed:29215007 + + complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("261_265"))) increases p(CONSO:CONSO00170) + + + + + + + pubmed:29215007 + + complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("277_283"))) increases bp(MESH:"Protein Conformation, alpha-Helical") + + + + + + + pubmed:29215007 + + p(HGNC:MAPT, var("p.Leu256Glu")) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_290"))) + + + + + + + pubmed:29215007 + + p(HGNC:MAPT, var("p.Leu256Glu")) decreases bp(GO:"actin filament bundle assembly") + + + + + + + pubmed:29215007 + + complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_290"))) increases bp(MESH:"Protein Conformation, alpha-Helical") + + + + + + + + + pubmed:29215007 + + p(HGNC:MAPT, frag("292_319")) increases bp(GO:"actin filament bundle assembly") + + + + + + + pubmed:29215007 + + p(HGNC:MAPT, frag("315_318")) increases p(CONSO:CONSO00170) + + + + + + + pubmed:29215007 + + complex(a(GO:"filamentous actin"), p(HGNC:MAPT, frag("254_268"))) increases bp(MESH:"Protein Conformation, alpha-Helical") + + + + + + + + + pubmed:29215007 + + p(HGNC:MAPT, frag("254_268")) decreases bp(GO:"actin filament bundle assembly") + + + + + + + + + pubmed:29215007 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 293)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) + + + + + + + pubmed:29215007 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 293)) decreases bp(GO:"actin filament bundle assembly") + + + + + + + pubmed:17493042 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 293)) decreases complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Tubulins)) + + + + + + + pubmed:17493042 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 293)) decreases p(CONSO:"Tau aggregates") + + + + + + + pubmed:17493042 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 293)) decreases bp(GO:"neurofibrillary tangle assembly") + + + + + + + pubmed:24251416 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 293)) partOf p(CONSO:"tubulin-binding repeat 2") + + + + + + + pubmed:29215007 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 305)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) + + + + + + + pubmed:29215007 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 305)) decreases bp(GO:"actin filament bundle assembly") + + + + + + + pubmed:24251416 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 305)) partOf p(CONSO:"tubulin-binding repeat 2") + + + + + + + pubmed:29215007 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 416)) decreases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) + + + + + + + pubmed:29215007 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 416)) decreases bp(GO:"actin filament bundle assembly") + + + + + + + + + pubmed:24027553 + + p(HGNC:MAPT, pmod(CONSO:nitration)) association path(MESH:"Neurofibrillary Tangles") + + + + + + + pubmed:24027553 + + act(a(CHEBI:Thrombin)) increases deg(p(HGNC:MAPT)) + + + + + + + pubmed:24027553 + + act(a(CHEBI:Thrombin)) increases deg(p(HGNC:MAPT)) + + + + + + + pubmed:24027553 + + a(CHEBI:Thrombin) increases bp(GO:coagulation) + + + + + + + pubmed:24027553 + + a(CHEBI:Thrombin) increases path(CONSO:"neurite retraction") + + + + + + + pubmed:24027553 + + a(CHEBI:Thrombin) increases bp(GO:"apoptotic process") + + + + + + + pubmed:24027553 + + a(CHEBI:Thrombin) increases bp(GO:"apoptotic process") + + + + + + + pubmed:24027553 + + a(CHEBI:Thrombin) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:24027553 + + a(CHEBI:Thrombin, loc(MESH:Neurons)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:24027553 + + a(CHEBI:Thrombin, loc(MESH:Astrocytes)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:24027553 + + a(CHEBI:Thrombin) association path(MESH:"Neurofibrillary Tangles") + + + + + + + pubmed:24027553 + + act(a(CHEBI:Thrombin)) increases p(HGNC:MAPT, frag("1_?")) + + + + + + + pubmed:24027553 + + act(a(CHEBI:Thrombin)) causesNoChange p(HGNC:MAPT, frag("561_685")) + + + + + + + pubmed:24027553 + + act(a(CHEBI:Thrombin)) increases deg(p(HGNC:MAPT, frag("561_685"))) + + + + + + + pubmed:24027553 + + act(a(CHEBI:Thrombin)) increases act(p(HGNCGENEFAMILY:Caspases)) + + + + + + + pubmed:24027553 + + act(p(HGNC:HTRA1)) increases deg(p(HGNC:MAPT)) + + + + + + + pubmed:24027553 + + act(p(HGNC:HTRA1)) increases deg(p(HGNC:MAPT)) + + + + + + + pubmed:29626319 + + p(HGNC:HTRA1) increases deg(p(HGNC:MAPT)) + + + + + + + pubmed:24027553 + + p(HGNC:HTRA1) association bp(CONSO:"APP processing") + + + + + + + pubmed:24027553 + + p(HGNC:HTRA1) association path(MESH:"Alzheimer Disease") + + + + + + + pubmed:24027553 + + act(p(HGNC:HTRA1)) increases deg(p(HGNCGENEFAMILY:Tubulins)) + + + + + + + pubmed:24027553 + + act(p(HGNC:HTRA1)) regulates act(a(MESH:Microtubules)) + + + + + + + pubmed:24027553 + + act(p(HGNC:HTRA1)) increases deg(a(CONSO:"Tau fibrils")) + + + + + + + pubmed:24027553 + + act(p(HGNC:HTRA1)) increases deg(a(CONSO:"Tau aggregates")) + + + + + + + + + + + + + + + pubmed:24027553 + + p(HGNC:NPEPPS) increases act(p(HGNCGENEFAMILY:Aminopeptidases)) + + + + + + + pubmed:24027553 + + p(HGNC:NPEPPS) association path(MESH:Tauopathies) + + + + + + + pubmed:24027553 + + p(HGNC:NPEPPS) decreases path(MESH:Tauopathies) + + + + + + + pubmed:24027553 + + p(HGNC:NPEPPS) positiveCorrelation p(MGI:Mapt, var("p.Pro301Leu")) + + + + + + + pubmed:24027553 + + p(HGNC:NPEPPS) decreases p(MGI:Mapt, var("p.Pro301Leu")) + + + + + + + pubmed:24027553 + + p(HGNC:NPEPPS) positiveCorrelation path(MESH:"Frontotemporal Dementia") + + + + + + + pubmed:24027553 + + p(HGNC:NPEPPS) decreases p(HGNC:MAPT) + + + + + + + pubmed:24027553 + + p(HGNC:NPEPPS) regulates deg(p(HGNC:MAPT)) + + + + + + + pubmed:24027553 + + p(HGNC:NPEPPS) increases deg(p(HGNC:MAPT)) + + + + + + + pubmed:24027553 + + p(HGNC:NPEPPS) decreases path(MESH:Paralysis) + + + + + + + pubmed:24027553 + + p(HGNC:NPEPPS) decreases path(MESH:Gliosis) + + + + + + + pubmed:24027553 + + p(HGNC:NPEPPS) increases p(HGNC:MAPT, frag("1_?")) + + + + + + + pubmed:24027553 + + p(HGNC:NPEPPS) increases p(HGNC:MAPT, frag("?_*")) + + + + + + + pubmed:24027553 + + p(HGNC:NPEPPS) increases bp(GO:autophagy) + + + + + + + pubmed:24027553 + + p(HGNC:NPEPPS) increases bp(GO:"autophagosome assembly") + + + + + + + pubmed:24027553 + + p(HGNC:PIN1) association path(MESH:"Alzheimer Disease") + + + + + + + pubmed:23157676 + + act(p(HGNC:PIN1)) decreases path(MESH:"Alzheimer Disease") + + + + + + + pubmed:24027553 + + p(HGNC:PIN1) decreases deg(p(HGNC:MAPT, var("p.Pro301Leu"))) + + + + + + + pubmed:26751493 + + p(HGNC:PIN1) association p(CONSO:"projection domain") + + + + + + + + + + + + + pubmed:25899010 + + p(HGNC:PIN1) decreases path(CONSO:Excitotoxicity) + + + + + + + pubmed:25899010 + + p(HGNC:PIN1) decreases path(CONSO:Neurodegeneration) + + + + + + + + + + + pubmed:24964035 + + p(HGNC:PIN1) regulates deg(p(HGNC:SMAD2)) + + + + + + + pubmed:24964035 + + p(HGNC:PIN1) increases complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")), p(HGNC:SMAD2)) + + + + + + + pubmed:23157676 + + act(p(HGNC:PIN1)) decreases p(CONSO:"cis p-tau") + + + + + + + pubmed:26996941 + + act(p(HGNC:PIN1)) association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 235)) + + + + + + + + + + + + + + + + + pubmed:19401603 + + p(HGNC:PIN1) increases act(p(HGNC:PPP2CA)) + + + + + + + pubmed:24027553 + + deg(p(HGNC:MAPT, frag("561_685"))) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:24027553 + + p(HGNC:MAPT, frag("561_685")) positiveCorrelation a(CONSO:"Tau aggregates") + + + + + + + pubmed:24027553 + + p(CONSO:"cis p-tau") decreases deg(p(CONSO:"cis p-tau")) + + + + + + + pubmed:24027553 + + p(CONSO:"cis p-tau") decreases act(p(HGNC:PIN1)) + + + + + + + pubmed:23157676 + + p(CONSO:"cis p-tau") positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:23157676 + + p(CONSO:"cis p-tau") increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:24027553 + + p(HGNC:MAPT, frag("?", "17kD")) increases path(CONSO:"neurite retraction") + + + + + + + pubmed:24027553 + + p(HGNC:MAPT, frag("?", "17kD")) causesNoChange path(CONSO:neurotoxicity) + + + + + + + pubmed:24027553 + + a(CHEBI:"calpain inhibitor") decreases p(HGNC:MAPT, frag("?", "17kD")) + + + + + + + pubmed:24027553 + + a(CHEBI:"calpain inhibitor") decreases p(HGNC:MAPT, frag("?", "35kD")) + + + + + + + pubmed:24027553 + + a(CHEBI:"calpain inhibitor") decreases p(HGNC:MAPT, frag("?", "24kD")) + + + + + + + pubmed:24027553 + + a(CHEBI:"calpain inhibitor") decreases act(p(HGNCGENEFAMILY:Calpains)) + + + + + + + pubmed:24027553 + + p(HGNC:MAPT, var("p.Asp421*")) isA p(CONSO:"Tau C3") + + + + + + + pubmed:25974414 + + p(HGNC:MAPT, var("p.Asp421*")) partOf a(GO:"neurofibrillary tangle") + + + + + + + pubmed:25974414 + + p(HGNC:MAPT, var("p.Asp421*")) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:26671985 + + p(HGNC:MAPT, var("p.Asp421*")) biomarkerFor path(MESH:"Chronic Traumatic Encephalopathy") + + + + + + + pubmed:26671985 + + p(HGNC:MAPT, var("p.Asp421*")) association path(CONSO:neurotoxicity) + + + + + + + pubmed:24027553 + + p(HGNC:MAPT, var("p.Asp421Glu")) decreases bp(GO:"apoptotic process") + + + + + + + pubmed:24027553 + + composite(a(MESH:"Amyloid beta-Peptides"), p(HGNC:CASP3)) increases p(CONSO:"Tau C3") + + + + + + + pubmed:24027553 + + a(MESH:"9-deoxy-delta-9-prostaglandin D2") increases act(p(HGNCGENEFAMILY:Caspases)) + + + + + + + pubmed:24027553 + + act(a(MESH:"Proteasome Endopeptidase Complex")) increases deg(p(HGNC:MAPT)) + + + + + + + pubmed:24027553 + + a(CHEBI:N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal) increases p(HGNC:MAPT) + + + + + + + pubmed:24027553 + + a(CHEBI:N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal) decreases act(a(CHEBI:"Hsp90 inhibitor")) + + + + + + + pubmed:30837838 + + a(CHEBI:N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal) increases path(MESH:"Stress, Physiological") + + + + + + + pubmed:24027553 + + act(a(CHEBI:"Hsp90 inhibitor")) decreases p(HGNC:MAPT) + + + + + + + pubmed:21882945 + + a(CHEBI:"Hsp90 inhibitor") increases deg(p(HGNC:MAPT)) + + + + + + + pubmed:21882945 + + a(CHEBI:"Hsp90 inhibitor") increases complex(a(MESH:Proteins), p(FPLX:HSP90)) + + + + + + + pubmed:24027553 + + bp(GO:"vacuolar acidification") increases bp(GO:proteolysis) + + + + + + + pubmed:24027553 + + bp(GO:"vacuolar acidification") increases bp(GO:autophagy) + + + + + + + pubmed:24027553 + + bp(GO:"vacuolar acidification") decreases a(MESH:Autophagosomes) + + + + + + + pubmed:24027553 + + composite(p(HGNC:CTSD), p(HGNC:MAPT)) decreases p(HGNC:MAPT) + + + + + + + pubmed:24027553 + + composite(p(HGNC:CTSD), p(HGNC:MAPT)) increases p(HGNC:MAPT, frag("?")) + + + + + + + pubmed:24027553 + + a(MESH:3-methyladenine) decreases bp(GO:"autophagosome assembly") + + + + + + + pubmed:24027553 + + a(MESH:3-methyladenine) increases p(HGNC:MAPT) + + + + + + + pubmed:24027553 + + bp(MESH:Autophagy) increases deg(p(HGNC:MAPT)) + + + + + + + pubmed:24027553 + + bp(MESH:Autophagy) causesNoChange p(HGNC:MAPT) + + + + + + + pubmed:24027553 + + bp(MESH:Autophagy) increases deg(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) + + + + + + + pubmed:24027553 + + bp(MESH:Autophagy) increases deg(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) + + + + + + + pubmed:24027553 + + bp(MESH:Autophagy) decreases p(HGNC:MAPT, var("p.Pro301Leu")) + + + + + + + pubmed:24027553 + + bp(MESH:Autophagy) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:24027553 + + bp(MESH:Autophagy) increases deg(a(CONSO:"Tau aggregates")) + + + + + + + pubmed:24027553 + + bp(MESH:Autophagy) increases deg(a(CONSO:"Tau aggregates")) + + + + + + + pubmed:24027553 + + bp(MESH:Autophagy) increases deg(a(CONSO:"Tau aggregates")) + + + + + + + pubmed:24027553 + + bp(MESH:Autophagy) decreases p(MGI:Mapt, var("p.Pro301Ser")) + + + + + + + pubmed:24027553 + + bp(MESH:Autophagy) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 212), var("p.Pro301Ser")) + + + + + + + pubmed:24027553 + + bp(MESH:Autophagy) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 214), var("p.Pro301Ser")) + + + + + + + pubmed:24027553 + + bp(MESH:Autophagy) negativeCorrelation bp(GO:"neuron death") + + + + + + + pubmed:24027553 + + bp(MESH:Autophagy) increases deg(p(CONSO:"Tau C3")) + + + + + + + pubmed:24027553 + + bp(MESH:Autophagy) decreases p(CONSO:"Tau C3") + + + + + + + pubmed:24027553 + + bp(MESH:Autophagy) decreases p(CONSO:"Tau epitope, AT8") + + + + + + + pubmed:24027553 + + bp(MESH:Autophagy) decreases p(CONSO:"Tau epitope, PHF1") + + + + + + + pubmed:24027553 + + bp(MESH:Autophagy) decreases p(CONSO:"Tau epitope, 12E8") + + + + + + + pubmed:24027553 + + bp(MESH:Autophagy) increases deg(a(CONSO:"Tau oligomers")) + + + + + + + pubmed:24027553 + + a(MESH:Trehalose) increases bp(MESH:Autophagy) + + + + + + + pubmed:24027553 + + a(MESH:Trehalose) increases bp(MESH:Autophagy) + + + + + + + pubmed:24027553 + + a(MESH:Trehalose) increases bp(MESH:Autophagy) + + + + + + + pubmed:24027553 + + a(MESH:Trehalose) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:24027553 + + a(MESH:Trehalose) decreases p(HGNC:MAPT) + + + + + + + pubmed:24027553 + + composite(a(MESH:Ubiquitin), p(HGNC:MAPT)) increases p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) + + + + + + + + + + + + + + + + + + + + + + + pubmed:16176937 + + p(RGD:Mapt) isA complex(p(RGD:Klc1), p(RGD:Mapt)) + + + + + + + + + pubmed:16176937 + + p(RGD:Mapt) isA complex(p(RGD:Klc2), p(RGD:Mapt)) + + + + + + + pubmed:20133804 + + act(p(RGD:Mapt)) increases bp(GO:"microtubule polymerization") + + + + + + + pubmed:20133804 + + act(p(RGD:Mapt)) increases bp(GO:"neuron projection development") + + + + + + + + + + + + + + + + + + + + + + + + + + + + + pubmed:22156579 + + p(CONSO:"Tau epitope, PHF1") positiveCorrelation p(CONSO:"Tau epitope, 12E8") + + + + + + + pubmed:22156579 + + p(CONSO:"Tau epitope, PHF1") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) + + + + + + + pubmed:22156579 + + p(CONSO:"Tau epitope, PHF1") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + + + + + + + pubmed:24033439 + + p(CONSO:"Tau epitope, PHF1") biomarkerFor path(MESH:"Alzheimer Disease") + + + + + + + pubmed:24033439 + + p(CONSO:"Tau epitope, PHF1") increases p(CONSO:"Tau aggregates") + + + + + + + + + pubmed:27574109 + + bp(GO:"positive regulation of protein oligomerization") positiveCorrelation p(CONSO:"4R tau") + + + + + + + pubmed:27574109 + + bp(GO:"positive regulation of protein oligomerization") positiveCorrelation p(CONSO:"3R tau") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform Fetal-tau (352 aa)") association p(CONSO:"phosphatase-activating domain") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform Fetal-tau (352 aa)") positiveCorrelation p(CONSO:"phosphatase-activating domain") + + + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform Fetal-tau (352 aa)") increases a(CONSO:"Tau oligomers") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform Fetal-tau (352 aa)") increases a(CONSO:"Tau oligomers") + + + + + + + pubmed:29191965 + + p(CONSO:"Tau isoform Fetal-tau (352 aa)") decreases bp(GO:locomotion) + + + + + + + + + pubmed:17493042 + + p(CONSO:"Tau isoform Fetal-tau (352 aa)") partOf a(MESH:Brain) + + + + + + + pubmed:27574109 + + p(CONSO:"phosphatase-activating domain") association p(CONSO:"Tau isoform Fetal-tau (352 aa)") + + + + + + + pubmed:27574109 + + p(CONSO:"phosphatase-activating domain") positiveCorrelation p(CONSO:"Tau isoform Fetal-tau (352 aa)") + + + + + + + pubmed:27574109 + + p(CONSO:"phosphatase-activating domain") association p(CONSO:"Tau isoform D (383 aa)") + + + + + + + pubmed:27574109 + + p(CONSO:"phosphatase-activating domain") positiveCorrelation p(CONSO:"Tau isoform D (383 aa)") + + + + + + + pubmed:27574109 + + p(CONSO:"phosphatase-activating domain") association p(CONSO:"Tau isoform C (410 aa)") + + + + + + + pubmed:27574109 + + p(CONSO:"phosphatase-activating domain") positiveCorrelation p(CONSO:"Tau isoform C (410 aa)") + + + + + + + pubmed:27574109 + + p(CONSO:"phosphatase-activating domain") positiveCorrelation p(CONSO:"Tau isoform D (383 aa)", pmod(CONSO:"protein aggregation")) + + + + + + + pubmed:27574109 + + p(CONSO:"phosphatase-activating domain") positiveCorrelation p(CONSO:"Tau isoform D (383 aa)", pmod(CONSO:"protein aggregation")) + + + + + + + pubmed:27574109 + + p(CONSO:"phosphatase-activating domain") positiveCorrelation p(CONSO:"Tau isoform C (410 aa)", pmod(CONSO:"protein aggregation")) + + + + + + + pubmed:27574109 + + p(CONSO:"phosphatase-activating domain") positiveCorrelation p(CONSO:"Tau isoform C (410 aa)", pmod(CONSO:"protein aggregation")) + + + + + + + pubmed:27574109 + + p(CONSO:"phosphatase-activating domain") positiveCorrelation p(CONSO:"Tau isoform Fetal-tau (352 aa)", pmod(CONSO:"protein aggregation")) + + + + + + + pubmed:27574109 + + p(CONSO:"phosphatase-activating domain") positiveCorrelation p(CONSO:"Tau isoform Fetal-tau (352 aa)", pmod(CONSO:"protein aggregation")) + + + + + + + pubmed:27574109 + + p(CONSO:"phosphatase-activating domain") positiveCorrelation p(CONSO:"Tau isoform B (381 aa)", pmod(CONSO:"protein aggregation")) + + + + + + + pubmed:27574109 + + p(CONSO:"phosphatase-activating domain") positiveCorrelation p(CONSO:"Tau isoform B (381 aa)", pmod(CONSO:"protein aggregation")) + + + + + + + pubmed:27574109 + + p(CONSO:"phosphatase-activating domain") positiveCorrelation p(CONSO:"Tau isoform F (441 aa)", pmod(CONSO:"protein aggregation")) + + + + + + + pubmed:27574109 + + p(CONSO:"phosphatase-activating domain") positiveCorrelation p(CONSO:"Tau isoform F (441 aa)", pmod(CONSO:"protein aggregation")) + + + + + + + pubmed:27574109 + + p(CONSO:"phosphatase-activating domain") positiveCorrelation p(CONSO:"Tau isoform E (412 aa)", pmod(CONSO:"protein aggregation")) + + + + + + + pubmed:27574109 + + p(CONSO:"phosphatase-activating domain") positiveCorrelation p(CONSO:"Tau isoform B (381 aa)") + + + + + + + pubmed:27574109 + + p(CONSO:"phosphatase-activating domain") positiveCorrelation p(CONSO:"Tau isoform F (441 aa)") + + + + + + + pubmed:27574109 + + p(CONSO:"phosphatase-activating domain") positiveCorrelation p(CONSO:"Tau isoform E (412 aa)") + + + + + + + pubmed:27574109 + + p(CONSO:"phosphatase-activating domain") association a(CONSO:pretangles) + + + + + + + pubmed:27574109 + + p(CONSO:"phosphatase-activating domain") association a(CONSO:"Braak_Stage I") + + + + + + + pubmed:27574109 + + p(CONSO:"phosphatase-activating domain") association a(CONSO:"Braak_Stage II") + + + + + + + pubmed:27574109 + + p(CONSO:"phosphatase-activating domain") association a(MESH:"Neurofibrillary Tangles") + + + + + + + pubmed:27574109 + + p(CONSO:"phosphatase-activating domain") association path(CONSO:"Corticobasal Degeneration") + + + + + + + pubmed:27574109 + + p(CONSO:"phosphatase-activating domain") positiveCorrelation path(CONSO:"Corticobasal Degeneration") + + + + + + + pubmed:27574109 + + p(CONSO:"phosphatase-activating domain") association a(GO:"Pick body") + + + + + + + pubmed:27574109 + + p(CONSO:"phosphatase-activating domain") positiveCorrelation path(MESH:Tauopathies) + + + + + + + pubmed:27574109 + + p(CONSO:"phosphatase-activating domain") positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:27574109 + + p(CONSO:"phosphatase-activating domain") positiveCorrelation path(MESH:"Pick Disease of the Brain") + + + + + + + + + pubmed:21734277 + + p(CONSO:"phosphatase-activating domain") increases act(p(CONSO:"Tau 6D")) + + + + + + + pubmed:21734277 + + p(CONSO:"phosphatase-activating domain") decreases bp(GO:"anterograde axonal protein transport") + + + + + + + pubmed:21734277 + + p(CONSO:"phosphatase-activating domain") decreases bp(GO:"anterograde axonal protein transport") + + + + + + + pubmed:21734277 + + p(CONSO:"phosphatase-activating domain") decreases bp(GO:"anterograde axonal protein transport") + + + + + + + pubmed:21734277 + + p(CONSO:"phosphatase-activating domain") causesNoChange bp(GO:"retrograde axonal protein transport") + + + + + + + + + pubmed:21734277 + + p(CONSO:"phosphatase-activating domain") decreases p(HGNC:JUN, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:21734277 + + p(CONSO:"phosphatase-activating domain") increases act(p(MESH:"Phosphoprotein Phosphatases")) + + + + + + + pubmed:21734277 + + p(CONSO:"phosphatase-activating domain") increases act(p(MESH:"Glycogen Synthase Kinase 3")) + + + + + + + pubmed:21734277 + + p(CONSO:"phosphatase-activating domain") increases act(p(MESH:"Glycogen Synthase Kinase 3")) + + + + + + + pubmed:21734277 + + p(CONSO:"phosphatase-activating domain") increases act(p(MESH:"Glycogen Synthase Kinase 3")) + + + + + + + pubmed:21734277 + + p(CONSO:"phosphatase-activating domain") increases act(p(MESH:"Protein Phosphatase 1")) + + + + + + + pubmed:21734277 + + p(CONSO:"phosphatase-activating domain") increases act(p(MESH:"Protein Phosphatase 1")) + + + + + + + pubmed:21734277 + + p(CONSO:"phosphatase-activating domain") association a(CONSO:"Tau antibody, TNT1") + + + + + + + pubmed:26671985 + + p(CONSO:"phosphatase-activating domain") equivalentTo p(HGNC:MAPT, frag("2_18")) + + + + + + + pubmed:26671985 + + p(CONSO:"phosphatase-activating domain") negativeCorrelation act(complex(GO:axon)) + + + + + + + pubmed:26671985 + + p(CONSO:"phosphatase-activating domain") biomarkerFor path(MESH:"Chronic Traumatic Encephalopathy") + + + + + + + pubmed:26671985 + + p(CONSO:"phosphatase-activating domain") decreases bp(GO:"axonal transport") + + + + + + + pubmed:21734277 + + p(CONSO:"phosphatase-activating domain") negativeCorrelation bp(GO:"axonal transport") + + + + + + + pubmed:27260838 + + p(CONSO:"phosphatase-activating domain") association p(CONSO:"Tau antibody, TNT1") + + + + + + + pubmed:27260838 + + p(CONSO:"phosphatase-activating domain") association p(CONSO:"Tau antibody, TNT2") + + + + + + + pubmed:27574109 + + p(CONSO:"phosphatase-activating domain") positiveCorrelation p(CONSO:"4R tau") + + + + + + + pubmed:27373205 + + p(CONSO:"phosphatase-activating domain") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) + + + + + + + pubmed:21734277 + + p(CONSO:"phosphatase-activating domain") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) + + + + + + + pubmed:21734277 + + p(CONSO:"phosphatase-activating domain") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) + + + + + + + pubmed:21734277 + + p(CONSO:"phosphatase-activating domain") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) + + + + + + + pubmed:21734277 + + p(CONSO:"phosphatase-activating domain") increases act(p(FPLX:PPP1)) + + + + + + + pubmed:21734277 + + p(CONSO:"phosphatase-activating domain") increases act(p(HGNC:GSK3B)) + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform D (383 aa)", pmod(CONSO:"protein aggregation")) positiveCorrelation p(CONSO:"phosphatase-activating domain") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform D (383 aa)", pmod(CONSO:"protein aggregation")) positiveCorrelation p(CONSO:"phosphatase-activating domain") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform D (383 aa)", pmod(CONSO:"protein aggregation")) increases a(CONSO:"Tau oligomers") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform D (383 aa)", pmod(CONSO:"protein aggregation")) increases a(CONSO:"Tau oligomers") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform D (383 aa)", pmod(CONSO:"protein aggregation")) increases a(CONSO:"Tau oligomers") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform D (383 aa)", pmod(CONSO:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform D (383 aa)", pmod(CONSO:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform D (383 aa)", pmod(CONSO:"protein aggregation")) causesNoChange bp(GO:"retrograde axonal transport") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform C (410 aa)", pmod(CONSO:"protein aggregation")) positiveCorrelation p(CONSO:"phosphatase-activating domain") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform C (410 aa)", pmod(CONSO:"protein aggregation")) positiveCorrelation p(CONSO:"phosphatase-activating domain") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform C (410 aa)", pmod(CONSO:"protein aggregation")) increases a(CONSO:"Tau oligomers") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform C (410 aa)", pmod(CONSO:"protein aggregation")) increases a(CONSO:"Tau oligomers") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform C (410 aa)", pmod(CONSO:"protein aggregation")) increases a(CONSO:"Tau oligomers") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform C (410 aa)", pmod(CONSO:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform C (410 aa)", pmod(CONSO:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform C (410 aa)", pmod(CONSO:"protein aggregation")) decreases bp(GO:"retrograde axonal transport") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform Fetal-tau (352 aa)", pmod(CONSO:"protein aggregation")) positiveCorrelation p(CONSO:"phosphatase-activating domain") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform Fetal-tau (352 aa)", pmod(CONSO:"protein aggregation")) positiveCorrelation p(CONSO:"phosphatase-activating domain") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform Fetal-tau (352 aa)", pmod(CONSO:"protein aggregation")) increases a(CONSO:"Tau oligomers") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform Fetal-tau (352 aa)", pmod(CONSO:"protein aggregation")) increases a(CONSO:"Tau oligomers") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform Fetal-tau (352 aa)", pmod(CONSO:"protein aggregation")) increases a(CONSO:"Tau oligomers") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform Fetal-tau (352 aa)", pmod(CONSO:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform Fetal-tau (352 aa)", pmod(CONSO:"protein aggregation")) causesNoChange bp(GO:"retrograde axonal transport") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform B (381 aa)", pmod(CONSO:"protein aggregation")) positiveCorrelation p(CONSO:"phosphatase-activating domain") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform B (381 aa)", pmod(CONSO:"protein aggregation")) positiveCorrelation p(CONSO:"phosphatase-activating domain") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform B (381 aa)", pmod(CONSO:"protein aggregation")) increases a(CONSO:"Tau oligomers") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform B (381 aa)", pmod(CONSO:"protein aggregation")) increases a(CONSO:"Tau oligomers") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform B (381 aa)", pmod(CONSO:"protein aggregation")) increases a(CONSO:"Tau oligomers") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform B (381 aa)", pmod(CONSO:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform B (381 aa)", pmod(CONSO:"protein aggregation")) causesNoChange bp(GO:"retrograde axonal transport") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform F (441 aa)", pmod(CONSO:"protein aggregation")) positiveCorrelation p(CONSO:"phosphatase-activating domain") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform F (441 aa)", pmod(CONSO:"protein aggregation")) positiveCorrelation p(CONSO:"phosphatase-activating domain") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform F (441 aa)", pmod(CONSO:"protein aggregation")) increases a(CONSO:"Tau oligomers") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform F (441 aa)", pmod(CONSO:"protein aggregation")) increases a(CONSO:"Tau oligomers") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform F (441 aa)", pmod(CONSO:"protein aggregation")) increases a(CONSO:"Tau oligomers") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform F (441 aa)", pmod(CONSO:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform F (441 aa)", pmod(CONSO:"protein aggregation")) causesNoChange bp(GO:"retrograde axonal transport") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform E (412 aa)", pmod(CONSO:"protein aggregation")) positiveCorrelation p(CONSO:"phosphatase-activating domain") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform E (412 aa)", pmod(CONSO:"protein aggregation")) increases a(CONSO:"Tau oligomers") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform E (412 aa)", pmod(CONSO:"protein aggregation")) increases a(CONSO:"Tau oligomers") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform E (412 aa)", pmod(CONSO:"protein aggregation")) increases a(CONSO:"Tau oligomers") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform E (412 aa)", pmod(CONSO:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform E (412 aa)", pmod(CONSO:"protein aggregation")) decreases bp(GO:"anterograde axonal transport") + + + + + + + pubmed:27574109 + + p(CONSO:"Tau isoform E (412 aa)", pmod(CONSO:"protein aggregation")) causesNoChange bp(GO:"retrograde axonal transport") + + + + + + + pubmed:27574109 + + a(CONSO:"Braak_Stage I") association a(CONSO:"Tau oligomers") + + + + + + + pubmed:27574109 + + a(CONSO:"Braak_Stage I") association p(CONSO:"phosphatase-activating domain") + + + + + + + pubmed:27574109 + + a(CONSO:"Braak_Stage I") association p(HGNC:MAPT) + + + + + + + pubmed:28176663 + + a(CONSO:"Braak_Stage I") positiveCorrelation act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:27574109 + + composite(p(CONSO:"phosphatase-activating domain"), p(HGNC:MAPT)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:27574109 + + composite(p(CONSO:"phosphatase-activating domain"), p(HGNC:MAPT)) positiveCorrelation path(MESH:"Pick Disease of the Brain") + + + + + + + pubmed:27574109 + + composite(p(CONSO:"phosphatase-activating domain"), p(HGNC:MAPT)) positiveCorrelation path(CONSO:"Corticobasal Degeneration") + + + + + + + pubmed:17403556 + + a(CONSO:"amyloid-beta derived diffusible ligands") decreases bp(MESH:"Cell Survival") + + + + + + + pubmed:17403556 + + a(CONSO:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:17403556 + + a(CONSO:"amyloid-beta derived diffusible ligands") increases p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:17403556 + + a(CONSO:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) + + + + + + + pubmed:17403556 + + a(CONSO:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) + + + + + + + pubmed:17403556 + + a(CONSO:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) + + + + + + + pubmed:17403556 + + a(CONSO:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) + + + + + + + + + pubmed:17403556 + + a(CONSO:"amyloid-beta derived diffusible ligands") increases complex(a(CONSO:"amyloid-beta derived diffusible ligands"), a(GO:synapse)) + + + + + + + pubmed:17403556 + + a(CONSO:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + + + + + + + pubmed:17403556 + + a(CONSO:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + + + + + + + pubmed:17403556 + + a(CONSO:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + + + + + + + pubmed:17403556 + + a(CONSO:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:17403556 + + a(CONSO:"amyloid-beta derived diffusible ligands") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 181)) + + + + + + + + + + + pubmed:26195256 + + deg(a(CONSO:"amyloid-beta derived diffusible ligands")) decreases a(CONSO:"amyloid-beta derived diffusible ligands") + + + + + + + pubmed:26195256 + + tloc(a(CONSO:"amyloid-beta derived diffusible ligands"), fromLoc(GO:"extracellular region"), toLoc(MESH:"Intracellular Space")) decreases a(CONSO:"amyloid-beta derived diffusible ligands") + + + + + + + pubmed:26195256 + + tloc(a(CONSO:"amyloid-beta derived diffusible ligands"), fromLoc(MESH:Brain), toLoc(MESH:Blood)) decreases a(CONSO:"amyloid-beta derived diffusible ligands") + + + + + + + pubmed:26195256 + + tloc(a(CONSO:"amyloid-beta derived diffusible ligands"), fromLoc(MESH:Blood), toLoc(MESH:"Cerebrospinal Fluid")) decreases a(CONSO:"amyloid-beta derived diffusible ligands") + + + + + + + pubmed:26195256 + + tloc(a(CONSO:"amyloid-beta derived diffusible ligands"), fromLoc(MESH:Brain), toLoc(MESH:"Extracellular Fluid")) decreases a(CONSO:"amyloid-beta derived diffusible ligands") + + + + + + + pubmed:26195256 + + tloc(a(CONSO:"amyloid-beta derived diffusible ligands"), fromLoc(MESH:"Cerebrospinal Fluid"), toLoc(MESH:"Cardiovascular System")) decreases a(CONSO:"amyloid-beta derived diffusible ligands") + + + + + + + pubmed:26195256 + + tloc(a(CONSO:"amyloid-beta derived diffusible ligands"), fromLoc(MESH:"Cerebrospinal Fluid"), toLoc(MESH:"Lymphatic System")) decreases a(CONSO:"amyloid-beta derived diffusible ligands") + + + + + + + pubmed:18096814 + + a(CONSO:"amyloid-beta derived diffusible ligands") increases tloc(p(MGI:Fyn), fromLoc(GO:cytoplasm), toLoc(GO:"membrane raft")) + + + + + + + pubmed:18096814 + + a(CONSO:"amyloid-beta derived diffusible ligands") increases tloc(p(MGI:Mapt), fromLoc(GO:cytoplasm), toLoc(GO:"membrane raft")) + + + + + + + pubmed:30985105 + + p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation p(RGD:Mapt, pmod(CONSO:O-GlcNAcylation)) + + + + + + + pubmed:20133804 + + p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation p(RGD:Fkbp4) + + + + + + + + + pubmed:29421605 + + p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation bp(GO:aging) + + + + + + + pubmed:17403556 + + a(CONSO:"amyloid-beta antibody, NU1") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + + + + + + + pubmed:17403556 + + a(CONSO:"amyloid-beta antibody, NU1") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) + + + + + + + pubmed:17403556 + + a(CONSO:"amyloid-beta antibody, NU1") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) + + + + + + + pubmed:17403556 + + a(CONSO:"amyloid-beta antibody, NU1") decreases complex(a(CONSO:"amyloid-beta derived diffusible ligands"), a(MESH:Neurons)) + + + + + + + pubmed:17403556 + + a(CONSO:"amyloid-beta antibody, NU1") decreases complex(a(CONSO:"amyloid-beta derived diffusible ligands"), a(MESH:Neurons)) + + + + + + + pubmed:17403556 + + a(CONSO:"amyloid-beta antibody, NU1") decreases complex(a(CONSO:"amyloid-beta derived diffusible ligands"), a(GO:synapse)) + + + + + + + pubmed:17403556 + + a(MESH:"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) + + + + + + + pubmed:17403556 + + a(MESH:"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine") decreases bp(GO:"signal transduction") + + + + + + + pubmed:17403556 + + a(MESH:"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine") decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:17403556 + + a(CHEBI:LY294002) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) + + + + + + + pubmed:17403556 + + a(CHEBI:LY294002) decreases bp(GO:"signal transduction") + + + + + + + pubmed:17403556 + + a(CHEBI:LY294002) decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:17403556 + + complex(a(CONSO:"amyloid-beta derived diffusible ligands"), p(HGNC:MAPT)) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:27671637 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) association a(GO:"somatodendritic compartment") + + + + + + + pubmed:27671637 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) causesNoChange a(GO:"neurofibrillary tangle") + + + + + + + pubmed:27671637 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) causesNoChange a(GO:"dendritic spine") + + + + + + + pubmed:27671637 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) causesNoChange a(CHEBI:ATP) + + + + + + + pubmed:27671637 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) causesNoChange act(a(GO:presynapse)) + + + + + + + + + pubmed:27671637 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) decreases a(GO:mitochondrion) + + + + + + + pubmed:29202785 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Hippocampus) + + + + + + + pubmed:29202785 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Hippocampus) + + + + + + + pubmed:29202785 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Hippocampus) + + + + + + + pubmed:29202785 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) + + + + + + + pubmed:29202785 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) + + + + + + + pubmed:29202785 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) + + + + + + + pubmed:29202785 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) + + + + + + + pubmed:29202785 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) + + + + + + + pubmed:29202785 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) + + + + + + + pubmed:29202785 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:Neurons) + + + + + + + pubmed:29202785 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases bp(GO:neurogenesis) + + + + + + + pubmed:29202785 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) negativeCorrelation act(a(MESH:Microglia)) + + + + + + + pubmed:29202785 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) decreases act(a(MESH:Microglia)) + + + + + + + pubmed:29202785 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) causesNoChange act(a(MESH:Microglia)) + + + + + + + pubmed:29202785 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) causesNoChange path(MESH:Inflammation) + + + + + + + pubmed:29202785 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases p(MGI:Mapt) + + + + + + + pubmed:29202785 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases p(MGI:Mapt) + + + + + + + pubmed:29202785 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases tloc(p(MGI:Mapt), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) + + + + + + + pubmed:29202785 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases p(MGI:Mapt) + + + + + + + pubmed:29202785 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases a(MESH:"Stem Cells") + + + + + + + pubmed:29202785 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases bp(GO:"neuron differentiation") + + + + + + + pubmed:29202785 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) decreases p(MGI:Wnt5a) + + + + + + + pubmed:29202785 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases p(MGI:Wnt3) + + + + + + + pubmed:29202785 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases p(MGI:Wnt3) + + + + + + + pubmed:27671637 + + a(GO:"somatodendritic compartment") association p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) + + + + + + + pubmed:27671637 + + a(GO:"somatodendritic compartment") association p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) + + + + + + + pubmed:27671637 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) association a(GO:"somatodendritic compartment") + + + + + + + pubmed:27671637 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) association a(HP:"Argyrophilic inclusion bodies") + + + + + + + pubmed:27671637 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation a(HP:"Argyrophilic inclusion bodies") + + + + + + + pubmed:27671637 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation a(MESH:Axons) + + + + + + + pubmed:27671637 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del"), loc(MESH:Dendrites)) decreases a(GO:"dendritic spine") + + + + + + + pubmed:27671637 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(GO:"dendritic spine") + + + + + + + pubmed:27671637 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del"), loc(MESH:Dendrites)) decreases act(a(GO:dendrite)) + + + + + + + pubmed:27671637 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation a(GO:"neurofibrillary tangle") + + + + + + + pubmed:27671637 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases bp(GO:"mitochondrial transport") + + + + + + + pubmed:27671637 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(GO:mitochondrion) + + + + + + + pubmed:27671637 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(GO:mitochondrion) + + + + + + + pubmed:27671637 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(GO:mitochondrion) + + + + + + + pubmed:27671637 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(CHEBI:ATP) + + + + + + + pubmed:27671637 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(CHEBI:ATP) + + + + + + + pubmed:27671637 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation act(a(MESH:Neurons)) + + + + + + + pubmed:29202785 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(MESH:Neurons) + + + + + + + pubmed:29202785 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(MESH:Neurons) + + + + + + + pubmed:29202785 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(MESH:Neurons) + + + + + + + pubmed:28528849 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(MESH:Neurons) + + + + + + + pubmed:27671637 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation p(MGI:Fos) + + + + + + + pubmed:27671637 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation bp(GO:"astrocyte activation") + + + + + + + pubmed:27671637 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation p(MGI:Gfap) + + + + + + + pubmed:27671637 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation bp(GO:"response to oxidative stress") + + + + + + + pubmed:27671637 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) negativeCorrelation p(MGI:Hmox1) + + + + + + + pubmed:27671637 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases act(a(GO:presynapse)) + + + + + + + + + pubmed:27671637 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases bp(GO:"spontaneous synaptic transmission") + + + + + + + pubmed:29202785 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:29202785 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(GO:synapse) + + + + + + + pubmed:28528849 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(GO:synapse) + + + + + + + pubmed:29202785 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) increases path(CONSO:Neurodegeneration) + + + + + + + pubmed:29202785 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation act(a(MESH:Microglia)) + + + + + + + pubmed:29202785 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) increases a(MESH:Microglia) + + + + + + + pubmed:29202785 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) increases act(a(MESH:Microglia)) + + + + + + + pubmed:29202785 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) increases path(MESH:Inflammation) + + + + + + + pubmed:29202785 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) increases path(MESH:Hypertrophy) + + + + + + + pubmed:29202785 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) increases tloc(p(MGI:Mapt), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) + + + + + + + pubmed:29202785 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) causesNoChange p(MGI:Mapt) + + + + + + + pubmed:29202785 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) causesNoChange p(MGI:Mapt) + + + + + + + pubmed:29202785 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) increases tloc(p(MGI:Mapt), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) + + + + + + + pubmed:29202785 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) causesNoChange a(MESH:"Stem Cells") + + + + + + + pubmed:29202785 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) increases bp(GO:"neuron differentiation") + + + + + + + pubmed:29202785 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases a(MESH:Hippocampus) + + + + + + + pubmed:28528849 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) decreases bp(GO:memory) + + + + + + + pubmed:28528849 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) increases a(CONSO:"Tau fibrils") + + + + + + + pubmed:28528849 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) increases a(CONSO:"Tau oligomers") + + + + + + + pubmed:28528849 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) increases p(CONSO:"Tau oligomers", var("p.Lys280del")) + + + + + + + pubmed:28528849 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) causesNoChange a(CHEBI:"reactive oxygen species") + + + + + + + pubmed:28528849 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) causesNoChange a(CHEBI:"calcium(2+)", loc(GO:intracellular)) + + + + + + + pubmed:27671637 + + a(HP:"Argyrophilic inclusion bodies") association p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) + + + + + + + pubmed:27671637 + + a(HP:"Argyrophilic inclusion bodies") positiveCorrelation p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) + + + + + + + pubmed:27671637 + + a(HP:"Argyrophilic inclusion bodies") causesNoChange p(MGI:Syp) + + + + + + + + + pubmed:27671637 + + p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 262), pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) decreases complex(a(GO:microtubule), p(MGI:Mapt)) + + + + + + + pubmed:27671637 + + complex(a(HP:"Argyrophilic inclusion bodies"), p(MGI:Mapt)) decreases deg(p(MGI:Mapt)) + + + + + + + pubmed:27671637 + + p(MGI:Fos) negativeCorrelation p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) + + + + + + + pubmed:27671637 + + p(MGI:Fos) biomarkerFor act(a(MESH:Neurons)) + + + + + + + pubmed:27671637 + + p(MGI:Gfap) negativeCorrelation p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) + + + + + + + pubmed:27671637 + + p(MGI:Gfap) biomarkerFor bp(GO:"astrocyte activation") + + + + + + + pubmed:27671637 + + p(MGI:Hmox1) negativeCorrelation p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) + + + + + + + pubmed:27671637 + + p(MGI:Hmox1) biomarkerFor bp(GO:"response to oxidative stress") + + + + + + + pubmed:27671637 + + a(CHEBI:adenosine) increases act(p(MGI:Adora1)) + + + + + + + pubmed:27671637 + + a(CHEBI:adenosine) decreases act(a(MESH:Neurons)) + + + + + + + pubmed:27671637 + + a(CHEBI:adenosine) decreases p(MGI:Fos) + + + + + + + pubmed:27671637 + + a(CHEBI:adenosine) decreases act(a(GO:presynapse)) + + + + + + + pubmed:27671637 + + a(CHEBI:adenosine) decreases bp(GO:"long-term synaptic potentiation") + + + + + + + pubmed:21882945 + + a(CHEBI:adenosine) decreases act(p(INTERPRO:"Heat shock protein 70 family")) + + + + + + + pubmed:27671637 + + act(p(MGI:Adora1)) decreases act(a(MESH:Neurons)) + + + + + + + pubmed:27671637 + + act(p(MGI:Adora1)) decreases act(a(GO:presynapse)) + + + + + + + pubmed:27671637 + + act(p(MGI:Adora1)) decreases bp(GO:"long-term synaptic potentiation") + + + + + + + pubmed:27671637 + + a(PUBCHEM:64627) decreases act(p(MGI:Adora1)) + + + + + + + pubmed:27671637 + + a(PUBCHEM:64627) increases act(a(MESH:Neurons)) + + + + + + + pubmed:27671637 + + a(PUBCHEM:64627) increases r(MGI:Fos) + + + + + + + pubmed:27671637 + + a(PUBCHEM:64627) increases act(a(GO:presynapse)) + + + + + + + pubmed:27671637 + + a(PUBCHEM:64627) causesNoChange a(GO:"dendritic spine") + + + + + + + + + + + pubmed:27671637 + + a(PUBCHEM:64627) decreases a(GO:mitochondrion) + + + + + + + pubmed:27671637 + + a(MESH:"BSc 3094") increases act(a(GO:presynapse)) + + + + + + + pubmed:27671637 + + composite(a(PUBCHEM:64627), p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del"))) decreases a(GO:"dendritic spine") + + + + + + + pubmed:27671637 + + composite(a(PUBCHEM:64627), p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del"))) causesNoChange a(GO:"dendritic spine") + + + + + + + pubmed:27671637 + + composite(a(PUBCHEM:64627), p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del"))) causesNoChange a(GO:"dendritic spine") + + + + + + + pubmed:27671637 + + composite(a(PUBCHEM:64627), p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del"))) causesNoChange act(a(GO:presynapse)) + + + + + + + pubmed:27671637 + + composite(a(PUBCHEM:64627), p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del"))) causesNoChange act(a(MESH:Neurons)) + + + + + + + pubmed:27671637 + + composite(a(PUBCHEM:64627), p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del"))) causesNoChange p(MGI:Fos) + + + + + + + pubmed:27671637 + + composite(a(PUBCHEM:64627), p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del"))) causesNoChange path(MESH:"Spatial Memory") + + + + + + + pubmed:27671637 + + composite(a(PUBCHEM:64627), p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases bp(GO:"long-term memory") + + + + + + + pubmed:27671637 + + composite(a(PUBCHEM:64627), p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del"))) causesNoChange bp(GO:"associative learning") + + + + + + + pubmed:27671637 + + composite(a(PUBCHEM:64627), p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases bp(GO:"excitatory postsynaptic potential") + + + + + + + pubmed:27671637 + + composite(a(PUBCHEM:64627), p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del"))) increases bp(GO:"spontaneous synaptic transmission") + + + + + + + pubmed:27671637 + + composite(a(PUBCHEM:64627), p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del"))) causesNoChange a(GO:"dendritic spine") + + + + + + + pubmed:28784767 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 208)) partOf p(CONSO:"Tau epitope, AT8") + + + + + + + pubmed:22833681 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 208)) partOf p(CONSO:"Tau epitope, AT8") + + + + + + + pubmed:28784767 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 208)) decreases a(CONSO:"Tau Protein Secondary Structure, Turn") + + + + + + + pubmed:26751493 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 208)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:22833681 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 208)) increases complex(p(HGNC:FYN), p(HGNC:MAPT)) + + + + + + + pubmed:28784767 + + p(HGNC:MAPT, var("p.Gly207Val")) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:28784767 + + p(HGNC:MAPT, var("p.Gly207Val")) decreases a(CONSO:"Tau Protein Secondary Structure, Turn") + + + + + + + pubmed:28784767 + + p(HGNC:MAPT, var("p.Gly207Val")) increases p(CONSO:"Tau aggregates") + + + + + + + pubmed:28784767 + + a(CONSO:"Tau Protein Secondary Structure, Turn") decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:28784767 + + a(CONSO:"Tau Protein Secondary Structure, Turn") decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:28784767 + + a(CONSO:"Tau Protein Secondary Structure, Turn") decreases p(CONSO:"Tau aggregates") + + + + + + + pubmed:28784767 + + a(CONSO:"Tau Protein Secondary Structure, Turn") decreases p(CONSO:"Tau aggregates") + + + + + + + pubmed:28784767 + + act(p(FPLX:CSNK1), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 208)) + + + + + + + pubmed:25673844 + + p(FPLX:CSNK1) isA p(CONSO:"CK1 superfamily") + + + + + + + pubmed:25673844 + + p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(go:0006468 ! "protein phosphorylation", Ser, 42)) + + + + + + + pubmed:25673844 + + p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(go:0006468 ! "protein phosphorylation", Ser, 45)) + + + + + + + pubmed:25673844 + + p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(go:0006468 ! "protein phosphorylation", Ser, 47)) + + + + + + + pubmed:25673844 + + p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(go:0006468 ! "protein phosphorylation", Ser, 80)) + + + + + + + pubmed:25673844 + + p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(go:0006468 ! "protein phosphorylation", Ser, 81)) + + + + + + + pubmed:25673844 + + p(FPLX:CSNK1) increases p(HGNC:SV2A, pmod(go:0006468 ! "protein phosphorylation", Thr, 84)) + + + + + + + pubmed:28784767 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205), pmod(go:0006468 ! "protein phosphorylation", Thr, 208)) equivalentTo p(CONSO:"Tau epitope, AT8") + + + + + + + pubmed:29590627 + + a(CHEBI:dextran) increases tloc(a(CHEBI:dextran)) + + + + + + + pubmed:28420982 + + a(CHEBI:dextran) association a(CONSO:"Tau aggregates") + + + + + + + pubmed:29590627 + + a(CHEBI:dynasore) decreases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + + + + + + + pubmed:29590627 + + a(CHEBI:dynasore) decreases tloc(a(CONSO:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + + + + + + + pubmed:29590627 + + a(CHEBI:dynasore) decreases tloc(a(CONSO:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + + + + + + + + + pubmed:29686391 + + a(CHEBI:dynasore) decreases act(p(HGNC:DNM2)) + + + + + + + pubmed:29686391 + + a(CHEBI:dynasore) decreases tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:29590627 + + a(CHEBI:"cytochalasin D") decreases bp(GO:"actin filament polymerization") + + + + + + + pubmed:29590627 + + a(CHEBI:"cytochalasin D") negativeCorrelation bp(GO:"bulk synaptic vesicle endocytosis") + + + + + + + pubmed:29590627 + + a(CHEBI:"cytochalasin D") negativeCorrelation bp(GO:macropinocytosis) + + + + + + + pubmed:29590627 + + a(CHEBI:"cytochalasin D") decreases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + + + + + + + pubmed:29590627 + + a(CHEBI:"cytochalasin D") causesNoChange tloc(a(CONSO:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + + + + + + + pubmed:29590627 + + a(CHEBI:"cytochalasin D") causesNoChange tloc(a(CONSO:"Tau aggregates"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + + + + + + + + + pubmed:29590627 + + bp(GO:"actin filament polymerization") positiveCorrelation bp(GO:"bulk synaptic vesicle endocytosis") + + + + + + + pubmed:29590627 + + bp(GO:"actin filament polymerization") positiveCorrelation bp(GO:macropinocytosis) + + + + + + + pubmed:29590627 + + bp(GO:"actin filament polymerization") increases tloc(a(CONSO:"Tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + + + + + + + pubmed:24760868 + + bp(GO:"actin filament polymerization") increases complex(GO:"filamentous actin") + + + + + + + pubmed:27041503 + + bp(GO:"actin filament polymerization") increases bp(MESH:"Long-Term Potentiation") + + + + + + + pubmed:29590627 + + composite(a(CHEBI:dynasore), p(HGNC:MAPT, var("p.Pro301Ser"))) causesNoChange tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + + + + + + + pubmed:29590627 + + composite(a(CHEBI:"cytochalasin D"), p(HGNC:MAPT, var("p.Pro301Ser"))) decreases tloc(p(HGNC:MAPT, var("p.Pro301Ser")), fromLoc(GO:"extracellular region"), toLoc(MESH:Neurons)) + + + + + + + pubmed:22611162 + + p(HGNC:MAPT, var("p.Lys280del")) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:22611162 + + p(HGNC:MAPT, var("p.Lys280del")) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, var("p.Lys280del")) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, var("p.Lys280del")) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, var("p.Lys280del")) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:22611162 + + p(HGNC:MAPT, var("p.Lys280del")) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:22611162 + + p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:locomotion) + + + + + + + pubmed:22611162 + + p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:"dorsal spinal cord development") + + + + + + + pubmed:22611162 + + p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:"dorsal spinal cord development") + + + + + + + pubmed:22611162 + + p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:"ventral spinal cord development") + + + + + + + pubmed:22611162 + + p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:"ventral spinal cord development") + + + + + + + pubmed:22611162 + + p(HGNC:MAPT, var("p.Lys280del")) increases path(CONSO:neurotoxicity) + + + + + + + pubmed:22611162 + + p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:"nervous system development") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, var("p.Lys280del")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, var("p.Lys280del")) decreases p(CONSO:"4R tau") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, var("p.Lys280del")) increases p(CONSO:"3R tau") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:memory) + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, var("p.Lys280del")) increases tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"somatodendritic compartment")) + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, var("p.Lys280del")) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, var("p.Lys280del")) increases a(GO:"neurofibrillary tangle") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, var("p.Lys280del")) decreases bp(GO:cognition) + + + + + + + pubmed:11606569 + + p(HGNC:MAPT, var("p.Lys280del")) equivalentTo g(DBSNP:rs63750688) + + + + + + + pubmed:11606569 + + p(HGNC:MAPT, var("p.Lys280del")) positiveCorrelation p(CONSO:"VQIINK motif") + + + + + + + pubmed:11606569 + + p(HGNC:MAPT, var("p.Lys280del")) positiveCorrelation p(CONSO:"VQIVYK motif") + + + + + + + pubmed:22611162 + + p(HGNC:MAPT, var("p.Ile277Pro")) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:22611162 + + p(HGNC:MAPT, var("p.Ile308Pro")) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:22611162 + + p(HGNC:MAPT, var("p.Val277Met")) association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) + + + + + + + pubmed:22611162 + + p(HGNC:MAPT, var("p.Val277Met")) association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + + + + + + + pubmed:22611162 + + p(HGNC:MAPT, var("p.Val277Met")) increases path(CONSO:neurotoxicity) + + + + + + + pubmed:22611162 + + p(HGNC:MAPT, var("p.Val277Met")) decreases bp(GO:"nervous system development") + + + + + + + pubmed:22611162 + + a(PUBCHEM:25096749) increases bp(GO:locomotion) + + + + + + + pubmed:22611162 + + a(PUBCHEM:25096749) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:22611162 + + a(CONSO:bb14) increases bp(GO:locomotion) + + + + + + + pubmed:22611162 + + a(CONSO:cmp16) decreases a(CONSO:"Tau fibrils") + + + + + + + pubmed:22611162 + + a(CONSO:cmp16) increases bp(GO:locomotion) + + + + + + + pubmed:22611162 + + a(CONSO:cmp16) decreases path(HP:Neurodegeneration) + + + + + + + pubmed:24760868 + + p(MESH:Actins) positiveCorrelation bp(GO:"long-term synaptic potentiation") + + + + + + + pubmed:24760868 + + p(MESH:Actins) positiveCorrelation bp(GO:"long-term synaptic potentiation") + + + + + + + pubmed:17187063 + + complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) increases complex(GO:"filamentous actin") + + + + + + + pubmed:17187063 + + complex(complex(GO:"filamentous actin"), p(HGNC:MAPT)) positiveCorrelation path(CONSO:Neurodegeneration) + + + + + + + + + pubmed:24760868 + + a(MESH:jasplakinolide) increases bp(GO:"actin filament polymerization") + + + + + + + pubmed:24760868 + + a(MESH:jasplakinolide) increases bp(GO:"actin filament polymerization") + + + + + + + pubmed:24760868 + + a(MESH:jasplakinolide) increases p(HGNC:MAPT) + + + + + + + pubmed:24760868 + + a(MESH:jasplakinolide) increases p(HGNC:GRIA1) + + + + + + + pubmed:24760868 + + a(MESH:jasplakinolide) decreases p(HGNC:FYN) + + + + + + + pubmed:24760868 + + a(CHEBI:"latrunculin A") increases bp(GO:"actin filament depolymerization") + + + + + + + pubmed:24760868 + + a(CHEBI:"latrunculin A") increases bp(GO:"actin filament depolymerization") + + + + + + + pubmed:24760868 + + a(CHEBI:"latrunculin A") decreases p(HGNC:MAPT) + + + + + + + pubmed:29202785 + + a(CHEBI:doxycycline) decreases p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) + + + + + + + pubmed:29202785 + + a(CHEBI:doxycycline) decreases p(CONSO:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) + + + + + + + pubmed:29202785 + + a(CHEBI:doxycycline) decreases p(MGI:Wnt5a) + + + + + + + pubmed:29202785 + + a(CHEBI:doxycycline) decreases p(MGI:Wnt3) + + + + + + + pubmed:21734277 + + p(CONSO:"Tau 6D") decreases bp(GO:"anterograde axonal protein transport") + + + + + + + pubmed:21734277 + + p(CONSO:"Tau 6D") decreases bp(GO:"anterograde axonal protein transport") + + + + + + + pubmed:21734277 + + act(p(CONSO:"Tau 6D")) decreases bp(GO:"anterograde axonal protein transport") + + + + + + + pubmed:21734277 + + p(CONSO:"Tau 6D") causesNoChange bp(GO:"retrograde axonal protein transport") + + + + + + + pubmed:21734277 + + p(CONSO:"Tau 6D") increases act(p(MESH:"Protein Phosphatase 1")) + + + + + + + pubmed:21734277 + + p(CONSO:"Tau 6D") increases act(p(MESH:"Glycogen Synthase Kinase 3")) + + + + + + + pubmed:21734277 + + p(CONSO:"Tau 6P") decreases bp(GO:"anterograde axonal protein transport") + + + + + + + pubmed:21734277 + + p(CONSO:"Tau 6P") causesNoChange bp(GO:"retrograde axonal protein transport") + + + + + + + pubmed:21734277 + + act(p(MESH:"Protein Phosphatase 1")) decreases bp(GO:"anterograde axonal protein transport") + + + + + + + pubmed:21734277 + + act(p(MESH:"Protein Phosphatase 1")) decreases bp(GO:"anterograde axonal protein transport") + + + + + + + pubmed:21734277 + + act(p(MESH:"Glycogen Synthase Kinase 3")) decreases bp(GO:"anterograde axonal protein transport") + + + + + + + pubmed:21734277 + + act(p(MESH:"Glycogen Synthase Kinase 3")) decreases bp(GO:"anterograde axonal protein transport") + + + + + + + pubmed:21734277 + + act(p(MESH:"Glycogen Synthase Kinase 3")) decreases bp(GO:"anterograde axonal protein transport") + + + + + + + pubmed:21734277 + + composite(p(CONSO:"phosphatase-activating domain"), p(HGNC:PPP1R2)) increases bp(GO:"anterograde axonal protein transport") + + + + + + + + + + + pubmed:21734277 + + p(CONSO:"Tau epitope, AT8", pmod(go:0006468 ! "protein phosphorylation")) association p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:21734277 + + p(CONSO:"Tau epitope, AT8", pmod(go:0006468 ! "protein phosphorylation")) association path(MESH:Tauopathies) + + + + + + + pubmed:21734277 + + p(HGNC:MAPT, var("p.Gly144_Ser273del")) decreases bp(GO:"anterograde axonal protein transport") + + + + + + + pubmed:21734277 + + p(HGNC:MAPT, var("p.Gly144_Ser273del")) causesNoChange bp(GO:"retrograde axonal protein transport") + + + + + + + pubmed:21734277 + + a(CONSO:"Tau antibody, TNT1") association p(CONSO:"phosphatase-activating domain") + + + + + + + pubmed:27373205 + + a(CONSO:"Tau antibody, TNT1") association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) + + + + + + + pubmed:28528849 + + p(CONSO:"Tau oligomers", var("p.Lys280del")) increases p(CONSO:"Tau fibrils", var("p.Lys280del")) + + + + + + + pubmed:28528849 + + p(CONSO:"Tau oligomers", var("p.Lys280del")) increases bp(GO:"cell death") + + + + + + + pubmed:28528849 + + p(CONSO:"Tau oligomers", var("p.Lys280del")) causesNoChange bp(GO:"cell death") + + + + + + + pubmed:28528849 + + p(CONSO:"Tau oligomers", var("p.Lys280del")) increases bp(GO:"apoptotic process") + + + + + + + pubmed:28528849 + + p(CONSO:"Tau oligomers", var("p.Lys280del")) increases bp(GO:"negative regulation of mitochondrial membrane potential") + + + + + + + pubmed:28528849 + + p(CONSO:"Tau oligomers", var("p.Lys280del")) increases act(p(HGNC:CASP3)) + + + + + + + pubmed:28528849 + + p(CONSO:"Tau oligomers", var("p.Lys280del")) increases act(p(HGNC:CASP7)) + + + + + + + pubmed:28528849 + + p(CONSO:"Tau oligomers", var("p.Lys280del")) increases tloc(p(HGNC:CYCS), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:28528849 + + p(CONSO:"Tau oligomers", var("p.Lys280del")) causesNoChange a(GO:membrane) + + + + + + + pubmed:28528849 + + p(CONSO:"Tau oligomers", var("p.Lys280del")) decreases a(MESH:"Dendritic Spines") + + + + + + + pubmed:28528849 + + p(CONSO:"Tau oligomers", var("p.Lys280del")) decreases a(MESH:"Dendritic Spines") + + + + + + + pubmed:28528849 + + p(CONSO:"Tau oligomers", var("p.Lys280del")) decreases a(MESH:"Dendritic Spines") + + + + + + + pubmed:28528849 + + p(CONSO:"Tau oligomers", var("p.Lys280del")) decreases a(MESH:"Dendritic Spines") + + + + + + + pubmed:28528849 + + p(CONSO:"Tau oligomers", var("p.Lys280del")) decreases a(GO:postsynapse) + + + + + + + pubmed:28528849 + + p(CONSO:"Tau oligomers", var("p.Lys280del")) decreases p(HGNC:GRIA1) + + + + + + + pubmed:28528849 + + p(CONSO:"Tau oligomers", var("p.Lys280del")) decreases p(HGNC:DBN1) + + + + + + + pubmed:28528849 + + p(CONSO:"Tau oligomers", var("p.Lys280del")) decreases p(HGNC:SYP) + + + + + + + pubmed:28528849 + + p(CONSO:"Tau oligomers", var("p.Lys280del")) increases a(CHEBI:"reactive oxygen species") + + + + + + + pubmed:28528849 + + p(CONSO:"Tau oligomers", var("p.Lys280del")) increases a(CHEBI:"reactive oxygen species") + + + + + + + pubmed:28528849 + + p(CONSO:"Tau oligomers", var("p.Lys280del")) increases p(HGNC:NOX1) + + + + + + + pubmed:28528849 + + p(CONSO:"Tau oligomers", var("p.Lys280del")) increases act(complex(GO:"NADPH oxidase complex")) + + + + + + + pubmed:28528849 + + p(CONSO:"Tau oligomers", var("p.Lys280del")) causesNoChange p(HGNC:CYBB) + + + + + + + pubmed:28528849 + + p(CONSO:"Tau oligomers", var("p.Lys280del")) increases a(CHEBI:"calcium(2+)", loc(GO:intracellular)) + + + + + + + pubmed:28528849 + + p(CONSO:"Tau oligomers", var("p.Lys280del")) causesNoChange p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) + + + + + + + pubmed:28528849 + + p(CONSO:"Tau oligomers", var("p.Lys280del")) causesNoChange p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) + + + + + + + pubmed:28528849 + + p(CONSO:"Tau oligomers", var("p.Lys280del")) causesNoChange p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) + + + + + + + pubmed:28528849 + + p(CONSO:"Tau oligomers", var("p.Lys280del")) causesNoChange tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(GO:"cell body")) + + + + + + + pubmed:28528849 + + p(CONSO:"Tau oligomers", var("p.Lys280del")) causesNoChange tloc(p(HGNC:MAPT), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) + + + + + + + pubmed:28528849 + + p(CONSO:"Tau oligomers", var("p.Lys280del")) decreases a(GO:synapse) + + + + + + + + + pubmed:23702978 + + tloc(p(HGNC:CYCS), fromLoc(MESH:Mitochondria), toLoc(MESH:Cytosol)) increases complex(p(HGNC:APAF1), p(HGNC:CYCS)) + + + + + + + pubmed:23702978 + + tloc(p(HGNC:CYCS), fromLoc(MESH:Mitochondria), toLoc(MESH:Cytosol)) increases act(complex(GO:apoptosome)) + + + + + + + pubmed:28528849 + + p(HGNC:DBN1) increases bp(GO:"synapse assembly") + + + + + + + pubmed:28528849 + + act(complex(GO:"NADPH oxidase complex")) increases a(CHEBI:"reactive oxygen species") + + + + + + + pubmed:23528736 + + p(HGNC:UBB) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + + + pubmed:23528736 + + p(HGNC:UBC) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:23528736 + + p(HGNC:UBA52) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:23528736 + + p(HGNC:RPS27A) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:23528736 + + p(CONSO:"UBB+1", pmod(go:0016567 ! "protein ubiquitination")) decreases bp(GO:"protein deubiquitination") + + + + + + + pubmed:23528736 + + p(CONSO:"UBB+1", pmod(go:0016567 ! "protein ubiquitination")) decreases act(p(FPLX:Proteasome)) + + + + + + + pubmed:23528736 + + p(CONSO:"UBB+1", pmod(go:0016567 ! "protein ubiquitination")) regulates path(HP:Neurodegeneration) + + + + + + + pubmed:23528736 + + p(CONSO:"UBB+1", pmod(go:0016567 ! "protein ubiquitination")) increases bp(MESH:"Stress, Physiological") + + + + + + + pubmed:23528736 + + p(CONSO:"UBB+1", pmod(go:0016567 ! "protein ubiquitination")) increases act(p(HGNC:TP53)) + + + + + + + pubmed:23528736 + + p(HGNCGENEFAMILY:"Ubiquitin like modifier activating enzymes") negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:23528736 + + p(HGNCGENEFAMILY:"Ubiquitin conjugating enzymes E2") negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:23528736 + + p(HGNC:RNF182) association path(MESH:"Neurodegenerative Diseases") + + + + + + + pubmed:23528736 + + p(HGNC:RNF182) association path(MESH:"Alzheimer Disease") + + + + + + + pubmed:23528736 + + complex(p(HGNC:HSPA8), p(HGNC:STUB1), p(HGNC:UBE2D2)) increases deg(p(HGNC:MAPT)) + + + + + + + + + pubmed:14612456 + + p(HGNC:UBE2D2) positiveCorrelation p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) + + + + + + + + + pubmed:14612456 + + p(HGNC:UBE2D2) isA complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")), p(HGNC:STUB1), p(HGNC:UBE2D2)) + + + + + + + + + pubmed:23528736 + + p(HGNC:BCL2L11, pmod(go:0006468 ! "protein phosphorylation")) increases bp(GO:autophagy) + + + + + + + pubmed:23528736 + + path(HP:"Neurofibrillary tangles") decreases act(p(FPLX:Proteasome)) + + + + + + + pubmed:23528736 + + p(HGNC:DCTN4) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:30108137 + + act(p(MGI:Tfeb)) association path(MESH:Tauopathies) + + + + + + + pubmed:30108137 + + p(MGI:Tfeb) decreases path(MESH:Tauopathies) + + + + + + + pubmed:30108137 + + p(MGI:Tfeb) increases p(MGI:Lamp1) + + + + + + + pubmed:30108137 + + p(MGI:Tfeb) increases p(MGI:Ctsa) + + + + + + + pubmed:30108137 + + p(MGI:Tfeb) increases p(MGI:Ctsb) + + + + + + + pubmed:30108137 + + p(MGI:Tfeb) regulates act(a(MESH:Lysosomes)) + + + + + + + pubmed:30108137 + + p(MGI:Tfeb) increases act(a(MESH:Phagocytes)) + + + + + + + pubmed:30108137 + + p(MGI:Tfeb) increases tloc(a(CONSO:"Tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:30108137 + + p(MGI:Tfeb) increases tloc(a(CONSO:"Tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:30108137 + + p(MGI:Tfeb) increases tloc(a(CONSO:"Tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:30108137 + + p(MGI:Tfeb) increases a(CONSO:"Tau fibrils", loc(GO:lysosome)) + + + + + + + + + pubmed:30108137 + + p(MGI:Tfeb) increases p(MGI:Tfeb, loc(GO:nucleus)) + + + + + + + pubmed:30108137 + + p(MGI:Tfeb, loc(GO:nucleus)) increases act(p(MGI:Tfeb)) + + + + + + + + + pubmed:30108137 + + p(MGI:Tfeb) increases bp(MESH:Phagocytosis) + + + + + + + pubmed:30108137 + + p(MGI:Tfeb) increases r(MGI:Lamp1) + + + + + + + pubmed:30108137 + + p(MGI:Tfeb) increases bp(MESH:Proteolysis) + + + + + + + pubmed:30108137 + + p(MGI:Tfeb) causesNoChange p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 396), pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + + + + + + + pubmed:30108137 + + p(MGI:Tfeb) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 396), pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + + + + + + + pubmed:30108137 + + p(MGI:Tfeb) causesNoChange p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) + + + + + + + pubmed:30108137 + + p(MGI:Tfeb) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) + + + + + + + pubmed:30108137 + + p(MGI:Tfeb) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) + + + + + + + pubmed:30108137 + + p(MGI:Tfeb) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 199), pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Ser, 208)) + + + + + + + pubmed:30108137 + + p(MGI:Tfeb) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) + + + + + + + pubmed:30108137 + + p(MGI:Tfeb) causesNoChange p(MGI:Mapt) + + + + + + + pubmed:30108137 + + p(MGI:Tfeb) decreases p(MGI:Mapt) + + + + + + + pubmed:30108137 + + p(MGI:Tfeb) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:30108137 + + p(MGI:Tfeb) decreases path(MESH:Gliosis) + + + + + + + pubmed:30108137 + + p(MGI:Tfeb) decreases a(GO:"neurofibrillary tangle") + + + + + + + pubmed:30108137 + + composite(a(CHEBI:"torin 1"), p(MGI:Tfeb)) increases tloc(a(CONSO:"Tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:28877763 + + p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) association p(HGNC:SYK, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:29221819 + + p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) positiveCorrelation p(MGI:Dyrk1a) + + + + + + + pubmed:25331948 + + p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) positiveCorrelation p(MGI:Syk) + + + + + + + pubmed:25887395 + + p(HGNC:MAPT, frag("243_375")) increases a(CONSO:"Tau fibrils") + + + + + + + + + pubmed:25887395 + + complex(a(CONSO:"Tau fibrils"), p(HGNCGENEFAMILY:Syndecans)) increases tloc(a(CONSO:"Tau fibrils"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + + + + + + + pubmed:25887395 + + complex(a(CONSO:"Tau fibrils"), p(HGNCGENEFAMILY:Syndecans)) increases a(CONSO:"Tau aggregates") + + + + + + + + + + + pubmed:29980653 + + p(HGNCGENEFAMILY:Syndecans) increases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:29980653 + + p(HGNCGENEFAMILY:Syndecans) increases tloc(p(HGNC:SNCA), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + + + pubmed:29980653 + + p(HGNCGENEFAMILY:Syndecans) association a(MESH:Glycosaminoglycans) + + + + + + + pubmed:29980653 + + p(HGNCGENEFAMILY:Syndecans) increases tloc(a(CONSO:"alpha-synuclein fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:25887395 + + a(CHEBI:"sodium chlorate") decreases complex(a(CONSO:"Tau fibrils"), p(HGNCGENEFAMILY:Syndecans)) + + + + + + + pubmed:25887395 + + a(CHEBI:"sodium chlorate") decreases p(HGNCGENEFAMILY:Syndecans, pmod(go:0006477 ! "protein sulfation")) + + + + + + + pubmed:25887395 + + a(CHEBI:"sodium chlorate") decreases a(CONSO:"Tau aggregates") + + + + + + + + + pubmed:29980653 + + p(HGNCGENEFAMILY:Syndecans, pmod(go:0006477 ! "protein sulfation")) increases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:25887395 + + complex(p(HGNC:MAPT, frag("243_375")), p(HGNC:MAPT, frag("243_375")), p(HGNC:MAPT, frag("243_375"))) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:25887395 + + complex(p(HGNC:MAPT, frag("243_375")), p(HGNC:MAPT, frag("243_375")), p(HGNC:MAPT, frag("243_375"))) increases tloc(a(CONSO:"Tau fibrils"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) + + + + + + + + + pubmed:29988016 + + p(HGNC:MAPT, var("p.Cys299Ala"), var("p.Cys322Ala")) decreases complex(p(HGNC:MAPT, var("p.Cys299Ala"), var("p.Cys322Ala")), p(HGNC:MAPT, var("p.Cys299Ala"), var("p.Cys322Ala"))) + + + + + + + pubmed:29988016 + + a(PUBCHEM:100984821) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:21882945 + + a(PUBCHEM:134222899) positiveCorrelation bp(GO:cognition) + + + + + + + pubmed:21882945 + + a(CHEBI:rhodanine) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:26751493 + + a(CHEBI:rhodanine) decreases p(CONSO:"Tau aggregates") + + + + + + + pubmed:21882945 + + a(CONSO:Phenylthiazolyl-hydrazide) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:29191965 + + a(CONSO:Phenylthiazolyl-hydrazide) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:29191965 + + a(CONSO:Phenylthiazolyl-hydrazide) increases bp(GO:locomotion) + + + + + + + pubmed:21882945 + + a(PUBCHEM:53789478) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:21882945 + + a(CHEBI:anthraquinone) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:21882945 + + a(CHEBI:benzothiazoles) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:21882945 + + p(INTERPRO:"Chaperone J-domain superfamily") increases act(p(INTERPRO:"Heat shock protein 70 family")) + + + + + + + pubmed:21882945 + + p(INTERPRO:"Chaperone J-domain superfamily") increases rxn(reactants(a(CHEBI:ATP)), products(a(CHEBI:"phosphate(3-)"), a(CHEBI:ADP))) + + + + + + + + + pubmed:21882945 + + a(MESH:"Guanine Nucleotide Exchange Factors") increases act(p(INTERPRO:"Heat shock protein 70 family")) + + + + + + + pubmed:21882945 + + a(MESH:"Guanine Nucleotide Exchange Factors") increases a(CHEBI:ADP) + + + + + + + + + + + + + pubmed:21882945 + + a(PUBCHEM:25195348) decreases act(a(MESH:"Adenosine Triphosphatases")) + + + + + + + pubmed:21882945 + + a(PUBCHEM:1056) decreases act(p(INTERPRO:"Heat shock protein 70 family")) + + + + + + + pubmed:21882945 + + a(PUBCHEM:1056) regulates complex(p(INTERPRO:"Chaperone J-domain superfamily"), p(INTERPRO:"Heat shock protein 70 family")) + + + + + + + pubmed:21882945 + + a(PUBCHEM:6444403) decreases act(p(INTERPRO:"Heat shock protein 70 family")) + + + + + + + pubmed:21882945 + + complex(p(FPLX:HSP90), p(FPLX:HSP90)) increases act(p(FPLX:HSP90)) + + + + + + + pubmed:21882945 + + p(INTERPRO:"Tetratricopeptide repeat-containing domain") regulates act(p(FPLX:HSP90), ma(GO:"ATPase activity")) + + + + + + + pubmed:21882945 + + a(PUBCHEM:6505803) directlyIncreases complex(a(PUBCHEM:9549213), p(INTERPRO:"Heat shock protein Hsp90, N-terminal")) + + + + + + + pubmed:21882945 + + a(PUBCHEM:6505803) directlyDecreases act(p(FPLX:HSP90)) + + + + + + + pubmed:21882945 + + a(PUBCHEM:6505803) decreases path(MESH:Neoplasms) + + + + + + + + + pubmed:21882945 + + a(PUBCHEM:9549213) directlyIncreases complex(a(PUBCHEM:9549213), p(INTERPRO:"Heat shock protein Hsp90, N-terminal")) + + + + + + + pubmed:21882945 + + a(PUBCHEM:9549213) directlyDecreases act(p(FPLX:HSP90)) + + + + + + + pubmed:21882945 + + a(PUBCHEM:9549213) decreases path(MESH:Neoplasms) + + + + + + + + + + + + + pubmed:21882945 + + a(CHEBI:novobiocin) directlyIncreases complex(a(CHEBI:novobiocin), p(INTERPRO:"HSP90, C-terminal domain")) + + + + + + + pubmed:21882945 + + a(CHEBI:novobiocin) directlyDecreases act(p(FPLX:HSP90)) + + + + + + + pubmed:21882945 + + a(CHEBI:novobiocin) decreases path(MESH:Neoplasms) + + + + + + + + + + + + + pubmed:21882945 + + a(PUBCHEM:501026) directlyIncreases complex(a(PUBCHEM:501026), p(INTERPRO:"HSP90, C-terminal domain")) + + + + + + + pubmed:21882945 + + a(PUBCHEM:501026) directlyDecreases act(p(FPLX:HSP90)) + + + + + + + pubmed:21882945 + + a(PUBCHEM:501026) decreases path(MESH:Neoplasms) + + + + + + + pubmed:21882945 + + a(CHEBI:celastrol) association act(p(FPLX:HSP90)) + + + + + + + pubmed:29311797 + + a(CHEBI:celastrol) decreases act(p(FPLX:HSP90)) + + + + + + + pubmed:29311797 + + a(CHEBI:celastrol) decreases act(p(HGNC:CDC37)) + + + + + + + pubmed:29311797 + + a(CHEBI:celastrol) decreases p(HGNC:MAPT) + + + + + + + + + pubmed:21882945 + + complex(p(FPLX:HSP90), p(HGNC:STUB1)) association p(HGNC:AKT1) + + + + + + + pubmed:25374103 + + complex(p(FPLX:HSP90), p(HGNC:STUB1)) increases complex(p(FPLX:HSP90), p(HGNC:STUB1), p(MESH:Proteins, pmod(CONSO:misfolded))) + + + + + + + pubmed:21882945 + + complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) increases deg(p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) + + + + + + + pubmed:21882945 + + complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) increases deg(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) + + + + + + + pubmed:14963027 + + complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) increases rxn(reactants(p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT))) + + + + + + + pubmed:14963027 + + complex(p(HGNC:HSPB1), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) increases deg(p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) + + + + + + + pubmed:21882945 + + complex(p(HGNC:BAG1), p(INTERPRO:"Heat shock protein 70 family")) increases p(HGNC:MAPT) + + + + + + + pubmed:20071522 + + complex(p(FPLX:HSP90), p(HGNC:MAPT)) positiveCorrelation p(HGNC:FKBP5) + + + + + + + pubmed:20071522 + + complex(p(HGNC:FKBP5), p(HGNC:MAPT)) association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) + + + + + + + pubmed:20071522 + + complex(p(HGNC:FKBP5), p(HGNC:MAPT)) association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) + + + + + + + pubmed:20071522 + + complex(p(HGNC:FKBP5), p(HGNC:MAPT)) association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) + + + + + + + pubmed:21882945 + + complex(p(FPLX:HSP90), p(HGNC:FKBP5)) increases complex(a(MESH:"Protein Phosphatase 2"), p(HGNC:MAPT)) + + + + + + + pubmed:21882945 + + complex(p(FPLX:HSP90), p(HGNC:FKBP5)) increases deg(p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) + + + + + + + pubmed:21882945 + + complex(p(FPLX:HSP90), p(HGNC:FKBP5)) causesNoChange p(HGNC:MAPT) + + + + + + + pubmed:29311797 + + complex(p(FPLX:HSP90), p(HGNC:FKBP5)) increases a(CONSO:"Tau oligomers") + + + + + + + pubmed:21882945 + + complex(a(MESH:"Protein Phosphatase 2"), p(HGNC:MAPT)) increases complex(a(GO:microtubule), p(HGNC:MAPT)) + + + + + + + + + pubmed:21882945 + + complex(a(MESH:Proteins), p(INTERPRO:"Heat shock protein 70 family")) positiveCorrelation complex(a(MESH:Proteins), p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) + + + + + + + pubmed:21882945 + + complex(a(MESH:Proteins), p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) positiveCorrelation complex(a(MESH:Proteins), p(INTERPRO:"Heat shock protein 70 family")) + + + + + + + pubmed:21882945 + + complex(a(MESH:Proteins), p(HGNC:STUB1), p(INTERPRO:"Heat shock protein 70 family")) increases bp(GO:"protein polyubiquitination") + + + + + + + pubmed:21882945 + + complex(a(MESH:Proteins), p(FPLX:HSP90)) increases deg(a(MESH:Proteins)) + + + + + + + pubmed:21882945 + + complex(p(HGNC:VHL), p(INTERPRO:"Heat shock protein 70 family")) increases deg(p(HGNC:VHL)) + + + + + + + pubmed:21882945 + + complex(p(FPLX:HSP90), p(HGNC:VHL)) increases deg(p(HGNC:VHL)) + + + + + + + pubmed:21882945 + + complex(p(HGNC:STIP1), p(HGNC:VHL)) increases deg(p(HGNC:VHL)) + + + + + + + pubmed:30126037 + + p(MGI:Cdkn2a) association bp(GO:"cellular senescence") + + + + + + + pubmed:30126037 + + p(MGI:Cdkn2a) positiveCorrelation path(HP:"Cerebral atrophy") + + + + + + + pubmed:30126037 + + p(MGI:Cdkn2a) positiveCorrelation a(GO:"neurofibrillary tangle") + + + + + + + pubmed:30126037 + + p(MGI:Cdkn2a) positiveCorrelation path(HP:"Brain atrophy") + + + + + + + pubmed:30126037 + + path(HP:"Cerebral atrophy") positiveCorrelation p(MGI:Cdkn2a) + + + + + + + pubmed:30126037 + + path(MESH:"Hypertrophy, Right Ventricular") association a(GO:"neurofibrillary tangle") + + + + + + + pubmed:30126037 + + path(MESH:"Hypertrophy, Left Ventricular") association a(GO:"neurofibrillary tangle") + + + + + + + pubmed:30126037 + + p(MGI:H2afx) biomarkerFor bp(MESH:"DNA Breaks, Double-Stranded") + + + + + + + pubmed:30126037 + + p(MGI:H2afx) biomarkerFor bp(GO:"cellular senescence") + + + + + + + pubmed:30126037 + + p(MGI:Glb1) positiveCorrelation a(HP:brain) + + + + + + + pubmed:30126037 + + a(HP:brain) positiveCorrelation p(MGI:Glb1) + + + + + + + pubmed:30126037 + + path(HP:"Brain atrophy") positiveCorrelation p(MGI:Cdkn2a) + + + + + + + pubmed:30126037 + + path(HP:"Brain atrophy") association a(GO:"neurofibrillary tangle") + + + + + + + pubmed:30126037 + + composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases a(GO:"neurofibrillary tangle") + + + + + + + pubmed:30126037 + + composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases a(GO:"neurofibrillary tangle") + + + + + + + pubmed:30126037 + + composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases a(GO:"neurofibrillary tangle") + + + + + + + pubmed:30126037 + + composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases bp(GO:"cellular senescence") + + + + + + + pubmed:30126037 + + composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases bp(GO:"cellular senescence") + + + + + + + pubmed:30126037 + + composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases path(HP:"Brain atrophy") + + + + + + + pubmed:30126037 + + composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases path(HP:"cardiac ventricle") + + + + + + + pubmed:30126037 + + composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases path(HP:"Hyperintensity of cerebral white matter on MRI") + + + + + + + pubmed:30126037 + + composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) decreases bp(MESH:"Cerebrovascular Circulation") + + + + + + + pubmed:30126037 + + composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) increases p(MGI:Syp) + + + + + + + pubmed:30126037 + + composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) increases p(MGI:Rbfox3) + + + + + + + pubmed:30126037 + + composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) increases p(MGI:Dlg4) + + + + + + + pubmed:30126037 + + composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) increases p(MGI:Aif1) + + + + + + + pubmed:30126037 + + composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) increases bp(MESH:Neuroprotection) + + + + + + + + + + + pubmed:30126037 + + path(MESH:"Cerebral Small Vessel Diseases") increases path(HP:"Hyperintensity of cerebral white matter on MRI") + + + + + + + pubmed:30126037 + + path(MESH:"Cerebral Small Vessel Diseases") increases path(MESH:Ischemia) + + + + + + + pubmed:30126037 + + path(MESH:"Cerebral Small Vessel Diseases") increases path(MESH:"Cognitive Dysfunction") + + + + + + + pubmed:30126037 + + path(MESH:"Cerebral Small Vessel Diseases") increases path(MESH:Dementia) + + + + + + + pubmed:28173111 + + p(MGI:Dlg4) negativeCorrelation p(MGI:Dnm1l) + + + + + + + pubmed:28173111 + + p(MGI:Dlg4) association act(complex(GO:"neuron to neuron synapse")) + + + + + + + pubmed:28408124 + + a(CONSO:"Tau antibody, Tau-13") decreases p(MGI:Mapt, loc(GO:cell)) + + + + + + + pubmed:28408124 + + a(CONSO:"Tau antibody, Tau-13") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + + + pubmed:28408124 + + a(CONSO:"Tau antibody, Tau-13") decreases p(HGNC:MAPT, loc(GO:cell)) + + + + + + + pubmed:28408124 + + a(CONSO:"Tau antibody, Tau-13") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:28408124 + + a(CONSO:"Tau antibody, 6C5") decreases p(MGI:Mapt, loc(GO:cell)) + + + + + + + pubmed:28408124 + + a(CONSO:"Tau antibody, 6C5") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:28408124 + + a(CONSO:"Tau antibody, 6C5") decreases p(HGNC:MAPT, loc(GO:cell)) + + + + + + + pubmed:28408124 + + a(CONSO:"Tau antibody, 6C5") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:28408124 + + a(CONSO:"Tau antibody, 6C5") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:28408124 + + a(CONSO:"Tau antibody, 6C5") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:28408124 + + a(CONSO:"Tau antibody, 6C5") decreases a(GO:"neurofibrillary tangle") + + + + + + + pubmed:28408124 + + a(CONSO:"Tau antibody, 6C5") decreases path(MESH:"Plaque, Amyloid") + + + + + + + pubmed:28408124 + + a(CONSO:"Tau antibody, 40E8") decreases p(MGI:Mapt, loc(GO:cell)) + + + + + + + pubmed:28408124 + + a(CONSO:"Tau antibody, 40E8") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:28408124 + + a(CONSO:"Tau antibody, 40E8") decreases p(HGNC:MAPT, loc(GO:cell)) + + + + + + + pubmed:28408124 + + a(CONSO:"Tau antibody, 40E8") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:28408124 + + a(CONSO:"Tau antibody, 40E8") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:28408124 + + a(CONSO:"Tau antibody, 40E8") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:28408124 + + a(CONSO:"Tau antibody, 40E8") decreases a(GO:"neurofibrillary tangle") + + + + + + + pubmed:28408124 + + a(CONSO:"Tau antibody, 40E8") decreases path(MESH:"Plaque, Amyloid") + + + + + + + pubmed:28408124 + + a(CONSO:"Tau antibody, 40E8") decreases a(MESH:"Neuropil Threads") + + + + + + + pubmed:28408124 + + a(CONSO:"Tau antibody, pS396") decreases p(MGI:Mapt, loc(GO:cell)) + + + + + + + pubmed:28408124 + + a(CONSO:"Tau antibody, pS396") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + + + pubmed:28408124 + + a(CONSO:"Tau antibody, pS396") decreases p(HGNC:MAPT, loc(GO:cell)) + + + + + + + pubmed:28408124 + + a(CONSO:"Tau antibody, pS396") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:28408124 + + a(CONSO:"Tau antibody, pS396") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:28408124 + + a(CONSO:"Tau antibody, 4E4") decreases p(MGI:Mapt, loc(GO:cell)) + + + + + + + pubmed:28408124 + + a(CONSO:"Tau antibody, 4E4") decreases tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:28408124 + + a(CONSO:"Tau antibody, 4E4") decreases p(HGNC:MAPT, loc(GO:cell)) + + + + + + + pubmed:28408124 + + a(CONSO:"Tau antibody, 4E4") decreases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:28408124 + + a(CONSO:"Tau antibody, Tau46") decreases p(MGI:Mapt, loc(GO:cell)) + + + + + + + pubmed:28408124 + + a(CONSO:"Tau antibody, Tau46") causesNoChange tloc(p(MGI:Mapt), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:28408124 + + a(CONSO:"Tau antibody, Tau46") decreases p(HGNC:MAPT, loc(GO:cell)) + + + + + + + pubmed:28408124 + + a(CONSO:"Tau antibody, Tau46") causesNoChange tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + + + + + pubmed:25995053 + + p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) decreases a(GO:"dendritic spine") + + + + + + + + + pubmed:28877763 + + p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) positiveCorrelation p(MGI:Syk) + + + + + + + pubmed:25331948 + + p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) positiveCorrelation p(MGI:Syk) + + + + + + + pubmed:25331948 + + a(CHEBI:Nilvadipine) decreases a(CHEBI:amyloid-beta) + + + + + + + pubmed:25331948 + + a(CHEBI:Nilvadipine) decreases a(CHEBI:amyloid-beta) + + + + + + + pubmed:25331948 + + a(CHEBI:Nilvadipine) decreases a(CHEBI:amyloid-beta) + + + + + + + pubmed:25331948 + + a(CHEBI:Nilvadipine) decreases a(CHEBI:amyloid-beta) + + + + + + + pubmed:25331948 + + a(CHEBI:Nilvadipine) increases deg(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:25331948 + + a(CHEBI:Nilvadipine) increases tloc(a(CHEBI:amyloid-beta), fromLoc(MESH:Brain), toLoc(MESH:Blood)) + + + + + + + pubmed:25331948 + + a(CHEBI:Nilvadipine) decreases act(p(HGNC:APP)) + + + + + + + pubmed:25331948 + + a(CHEBI:Nilvadipine) decreases tloc(p(CONSO:sAPP-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:25331948 + + a(CHEBI:Nilvadipine) decreases tloc(p(CONSO:sAPP-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:25331948 + + a(CHEBI:Nilvadipine) decreases r(HGNC:BACE1) + + + + + + + pubmed:25331948 + + a(CHEBI:Nilvadipine) decreases r(HGNC:BACE1) + + + + + + + pubmed:25331948 + + a(CHEBI:Nilvadipine) decreases r(HGNC:BACE1) + + + + + + + pubmed:25331948 + + a(CHEBI:Nilvadipine) decreases p(HGNC:BACE1) + + + + + + + pubmed:25331948 + + a(CHEBI:Nilvadipine) decreases p(HGNC:BACE1) + + + + + + + pubmed:25331948 + + a(CHEBI:Nilvadipine) decreases a(CHEBI:"amyloid-beta polypeptide 42") + + + + + + + pubmed:25331948 + + a(CHEBI:Nilvadipine) increases tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(MESH:Brain), toLoc(MESH:Plasma)) + + + + + + + pubmed:25331948 + + a(CHEBI:Nilvadipine) increases bp(GO:"amyloid-beta clearance by transcytosis") + + + + + + + pubmed:25331948 + + a(CHEBI:Nilvadipine) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) + + + + + + + pubmed:25331948 + + a(CHEBI:Nilvadipine) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) + + + + + + + pubmed:25331948 + + a(CHEBI:Nilvadipine) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) + + + + + + + pubmed:25331948 + + a(CHEBI:Nilvadipine) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) + + + + + + + pubmed:25331948 + + a(CHEBI:Nilvadipine) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + + + + + + + + + + + pubmed:25331948 + + a(CHEBI:Nilvadipine) decreases p(HGNC:RAF1, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:25331948 + + a(CHEBI:Nilvadipine) decreases act(p(HGNC:SYK)) + + + + + + + + + pubmed:25331948 + + a(CHEBI:Nilvadipine) increases complex(a(CHEBI:Nilvadipine), p(HGNC:SYK)) + + + + + + + pubmed:25331948 + + a(CHEBI:Nilvadipine) increases complex(a(CHEBI:Nilvadipine), p(HGNC:SYK)) + + + + + + + pubmed:25331948 + + a(CHEBI:Nilvadipine) decreases act(complex(GO:"NF-kappaB complex")) + + + + + + + pubmed:25331948 + + a(CHEBI:Nilvadipine) directlyDecreases complex(GO:"L-type voltage-gated calcium channel complex") + + + + + + + pubmed:25331948 + + a(CHEBI:Nilvadipine) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) + + + + + + + pubmed:25331948 + + a(CHEBI:Nilvadipine) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) + + + + + + + pubmed:25331948 + + a(CHEBI:Nilvadipine) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) + + + + + + + pubmed:25331948 + + a(CHEBI:Nilvadipine) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) + + + + + + + pubmed:25331948 + + a(CHEBI:Nilvadipine) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + + + + + + + pubmed:28877763 + + p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) positiveCorrelation p(MGI:Syk) + + + + + + + pubmed:25331948 + + p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) positiveCorrelation p(MGI:Syk) + + + + + + + pubmed:25331948 + + composite(a(CHEBI:Nilvadipine), p(HGNC:TNF)) decreases act(complex(GO:"NF-kappaB complex")) + + + + + + + pubmed:25331948 + + composite(a(CHEBI:"phorbol 13-acetate 12-myristate"), a(CHEBI:Nilvadipine)) decreases act(complex(GO:"NF-kappaB complex")) + + + + + + + + + pubmed:25331948 + + a(CHEBI:"phorbol 13-acetate 12-myristate") increases act(p(FPLX:PKC)) + + + + + + + pubmed:25331948 + + a(CHEBI:"phorbol 13-acetate 12-myristate") increases act(complex(GO:"NF-kappaB complex")) + + + + + + + pubmed:25331948 + + a(CHEBI:"phorbol 13-acetate 12-myristate") increases p(HGNC:RAF1, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:25331948 + + a(CHEBI:"phorbol 13-acetate 12-myristate") increases p(HGNC:RAF1, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:25331948 + + a(CHEBI:"phorbol 13-acetate 12-myristate") increases act(p(HGNC:SYK)) + + + + + + + pubmed:25331948 + + a(CHEBI:"phorbol 13-acetate 12-myristate") increases act(p(HGNC:BTK)) + + + + + + + pubmed:25331948 + + composite(p(FPLX:RHO), p(HGNC:ROCK1)) increases act(p(HGNC:TNF)) + + + + + + + pubmed:25331948 + + composite(p(FPLX:RHO), p(HGNC:ROCK1)) increases act(complex(GO:"NF-kappaB complex")) + + + + + + + + + + + pubmed:25331948 + + act(p(HGNC:SYK)) regulates act(complex(GO:"NF-kappaB complex")) + + + + + + + pubmed:25331948 + + p(HGNC:SYK) increases act(complex(GO:"NF-kappaB complex")) + + + + + + + pubmed:25331948 + + p(HGNC:SYK) regulates act(complex(GO:"NF-kappaB complex")) + + + + + + + + + pubmed:25331948 + + p(HGNC:SYK) increases a(CHEBI:amyloid-beta) + + + + + + + pubmed:25331948 + + act(p(HGNC:SYK)) increases a(CHEBI:amyloid-beta) + + + + + + + pubmed:25331948 + + act(p(HGNC:SYK)) decreases tloc(a(CHEBI:amyloid-beta), fromLoc(GO:intracellular), toLoc(MESH:Plasma)) + + + + + + + pubmed:25331948 + + act(p(HGNC:SYK)) increases tloc(p(CONSO:sAPP-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:28877763 + + p(HGNC:SYK) regulates p(CONSO:sAPP-beta) + + + + + + + pubmed:25331948 + + act(p(HGNC:SYK)) increases r(HGNC:BACE1) + + + + + + + pubmed:25331948 + + act(p(HGNC:SYK)) increases p(HGNC:BACE1) + + + + + + + pubmed:28877763 + + p(HGNC:SYK) regulates p(HGNC:BACE1) + + + + + + + pubmed:25331948 + + act(p(HGNC:SYK)) increases p(HGNC:RAF1, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:25331948 + + p(HGNC:SYK) regulates p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) + + + + + + + pubmed:28877763 + + act(p(HGNC:SYK), ma(go:0016301 ! "kinase activity")) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) + + + + + + + pubmed:28877763 + + act(p(HGNC:SYK)) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) + + + + + + + pubmed:28877763 + + p(HGNC:SYK) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) + + + + + + + pubmed:28877763 + + act(p(HGNC:SYK)) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) + + + + + + + pubmed:26631930 + + p(HGNC:SYK) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) + + + + + + + pubmed:25331948 + + act(p(HGNC:SYK)) increases act(p(HGNC:GSK3B)) + + + + + + + pubmed:28877763 + + p(HGNC:SYK) increases act(p(HGNC:GSK3B)) + + + + + + + pubmed:25331948 + + act(p(HGNC:SYK)) increases act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:25331948 + + p(HGNC:SYK) decreases act(p(FPLX:PKA)) + + + + + + + pubmed:25331948 + + p(HGNC:SYK) decreases act(p(FPLX:PKA)) + + + + + + + pubmed:25331948 + + p(HGNC:SYK) increases p(FPLX:PKA, pmod(go:0006468 ! "protein phosphorylation", Tyr, 330)) + + + + + + + pubmed:29191965 + + p(HGNC:SYK) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr)) + + + + + + + + + pubmed:28877763 + + act(p(HGNC:SYK)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396), pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + + + + + + + pubmed:28877763 + + p(HGNC:SYK) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396), pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + + + + + + + pubmed:28877763 + + act(p(HGNC:SYK)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) + + + + + + + pubmed:28877763 + + act(p(HGNC:SYK)) increases p(HGNC:MAPT, pmod(CONSO:misfolded)) + + + + + + + pubmed:28877763 + + act(p(HGNC:SYK)) positiveCorrelation p(HGNC:MAPT, pmod(CONSO:misfolded)) + + + + + + + pubmed:28877763 + + p(HGNC:SYK) increases p(HGNC:MAPT) + + + + + + + pubmed:28877763 + + p(HGNC:SYK) regulates deg(p(HGNC:MAPT)) + + + + + + + pubmed:28877763 + + p(HGNC:SYK) causesNoChange r(HGNC:MAPT) + + + + + + + pubmed:28877763 + + act(p(HGNC:SYK)) positiveCorrelation a(CONSO:"amyloid-beta aggregates") + + + + + + + pubmed:28877763 + + p(HGNC:SYK) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:28877763 + + p(HGNC:SYK) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:26501932 + + p(HGNC:SYK) partOf a(CONSO:pretangles) + + + + + + + pubmed:26501932 + + p(HGNC:SYK) partOf a(CONSO:"GVD bodies") + + + + + + + pubmed:25331948 + + act(p(HGNC:SYK)) decreases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) + + + + + + + pubmed:23702978 + + act(p(HGNC:SYK)) increases complex(p(HGNC:CASP8), p(HGNC:MALT1)) + + + + + + + pubmed:10887109 + + act(p(HGNC:SYK), ma(go:0016301 ! "kinase activity")) causesNoChange p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + + + pubmed:25331948 + + act(p(HGNC:BTK)) regulates act(complex(GO:"NF-kappaB complex")) + + + + + + + pubmed:25331948 + + a(PUBCHEM:71656932) decreases act(p(HGNC:BTK)) + + + + + + + pubmed:25331948 + + a(PUBCHEM:71656932) causesNoChange a(CHEBI:amyloid-beta) + + + + + + + pubmed:25331948 + + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases act(p(HGNC:SYK)) + + + + + + + pubmed:25331948 + + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases act(p(HGNC:SYK)) + + + + + + + pubmed:25331948 + + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases act(complex(GO:"NF-kappaB complex")) + + + + + + + pubmed:25331948 + + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases a(CHEBI:amyloid-beta) + + + + + + + pubmed:25331948 + + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") increases tloc(a(CHEBI:amyloid-beta), fromLoc(GO:intracellular), toLoc(MESH:Plasma)) + + + + + + + pubmed:25331948 + + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases tloc(p(CONSO:sAPP-beta), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:25331948 + + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases r(HGNC:BACE1) + + + + + + + pubmed:25331948 + + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(HGNC:BACE1) + + + + + + + pubmed:25331948 + + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(MGI:App, frag("1_38")) + + + + + + + pubmed:25331948 + + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases a(CHEBI:"amyloid-beta polypeptide 42") + + + + + + + pubmed:25331948 + + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") increases tloc(a(CHEBI:"amyloid-beta polypeptide 42"), fromLoc(GO:intracellular), toLoc(MESH:Plasma)) + + + + + + + pubmed:25331948 + + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases a(CHEBI:"amyloid-beta polypeptide 40") + + + + + + + pubmed:25331948 + + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) + + + + + + + pubmed:25331948 + + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) + + + + + + + pubmed:25331948 + + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + + + + + + + pubmed:25331948 + + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) + + + + + + + pubmed:25331948 + + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") causesNoChange p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Tyr, 231)) + + + + + + + pubmed:25331948 + + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") increases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) + + + + + + + pubmed:25331948 + + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") increases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) + + + + + + + pubmed:25331948 + + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) + + + + + + + pubmed:25331948 + + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + + + + + + + pubmed:25331948 + + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) + + + + + + + pubmed:25331948 + + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") causesNoChange p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 231)) + + + + + + + pubmed:25331948 + + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") decreases p(FPLX:AKT, pmod(go:0006468 ! "protein phosphorylation", Ser, 473)) + + + + + + + pubmed:25331948 + + a(CHEBI:"2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide") increases p(HGNC:CREB1, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:28877763 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) positiveCorrelation p(HGNC:SYK, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:28877763 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) positiveCorrelation p(HGNC:SYK, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:28877763 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) increases act(p(HGNC:SYK)) + + + + + + + pubmed:28877763 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) positiveCorrelation act(p(HGNC:SYK)) + + + + + + + pubmed:26751493 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) association a(CONSO:"paired helical filaments") + + + + + + + pubmed:16566606 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) positiveCorrelation a(GO:microtubule) + + + + + + + pubmed:28877763 + + p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) positiveCorrelation p(MGI:Syk) + + + + + + + pubmed:25331948 + + p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) positiveCorrelation p(MGI:Syk) + + + + + + + pubmed:25331948 + + p(FPLX:PKA, pmod(go:0006468 ! "protein phosphorylation", Tyr, 330)) decreases act(p(FPLX:PKA)) + + + + + + + pubmed:22419736 + + p(HGNC:AK1) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:22419736 + + p(HGNC:AK1) increases act(a(CHEBI:"amyloid-beta polypeptide 42")) + + + + + + + pubmed:22419736 + + p(HGNC:AK1) increases p(CONSO:"Tau aggregates") + + + + + + + pubmed:22419736 + + p(HGNC:AK1) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:22419736 + + p(HGNC:AK1) negativeCorrelation p(FPLX:AMPK, pmod(go:0006468 ! "protein phosphorylation", Thr, 172)) + + + + + + + + + pubmed:22419736 + + p(HGNC:AK1) decreases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) + + + + + + + pubmed:22419736 + + p(HGNC:AK1) regulates act(p(HGNC:GSK3B)) + + + + + + + pubmed:22419736 + + p(HGNC:AK1) regulates act(p(HGNC:GSK3B)) + + + + + + + pubmed:22419736 + + p(HGNC:AK1) regulates act(p(FPLX:AMPK)) + + + + + + + + + pubmed:22419736 + + p(HGNC:AK1) increases act(p(HGNC:MAPT)) + + + + + + + pubmed:22419736 + + p(HGNC:AK1) increases path(MESH:"Retinal Degeneration") + + + + + + + pubmed:22419736 + + p(HGNC:AK1) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:22419736 + + p(MGI:App, var("c.27269938A>C"), var("c.27269939G>T")) positiveCorrelation p(MGI:Ak1) + + + + + + + pubmed:22419736 + + p(MGI:Ak1) positiveCorrelation p(MGI:App, var("c.27269938A>C"), var("c.27269939G>T")) + + + + + + + pubmed:22419736 + + p(MGI:Ak1) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) + + + + + + + pubmed:22419736 + + p(MGI:Ak1) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) + + + + + + + pubmed:22419736 + + p(MGI:Ak1) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + + + + + + + pubmed:22419736 + + p(MGI:Ak1) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 231)) + + + + + + + pubmed:22419736 + + p(MGI:Ak1) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 235)) + + + + + + + + + pubmed:22419736 + + p(MESH:"Acetyl-CoA Carboxylase") association act(p(FPLX:AMPK)) + + + + + + + pubmed:22419736 + + p(HGNC:AK1, var("p.Arg132Ala")) causesNoChange p(FPLX:AMPK, pmod(go:0006468 ! "protein phosphorylation", Thr, 172)) + + + + + + + pubmed:22419736 + + p(HGNC:AK1, var("p.Arg132Ala")) causesNoChange p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) + + + + + + + pubmed:22419736 + + a(CHEBI:dorsomorphin) decreases act(p(FPLX:AMPK)) + + + + + + + pubmed:22419736 + + a(CHEBI:dorsomorphin) decreases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) + + + + + + + pubmed:22419736 + + a(CHEBI:dorsomorphin) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) + + + + + + + pubmed:22419736 + + a(CHEBI:dorsomorphin) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + + + + + + + pubmed:22419736 + + composite(p(HGNC:AK1), p(HGNC:MAPT)) increases path(MESH:"Retinal Degeneration") + + + + + + + pubmed:22419736 + + path(MESH:"Retinal Degeneration") association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:30640040 + + act(p(FPLX:TGFB)) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:30640040 + + a(PUBCHEM:9804992) decreases act(p(FPLX:HDAC)) + + + + + + + pubmed:30640040 + + a(PUBCHEM:9804992) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:30640040 + + a(PUBCHEM:9865515) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:30640040 + + a(PUBCHEM:9865515) association p(FPLX:HDAC) + + + + + + + pubmed:30640040 + + a(PUBCHEM:24756910) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:30640040 + + a(PUBCHEM:24756910) association p(FPLX:"HDAC_I") + + + + + + + pubmed:30640040 + + a(PUBCHEM:24756910) association p(FPLX:"HDAC_II") + + + + + + + pubmed:30640040 + + a(PUBCHEM:24756910) association p(HGNC:EGFR) + + + + + + + pubmed:30640040 + + a(PUBCHEM:24756910) association p(HGNC:ERBB2) + + + + + + + pubmed:30640040 + + a(PUBCHEM:448537) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:30640040 + + a(PUBCHEM:448537) association p(FPLX:ESR) + + + + + + + pubmed:30640040 + + a(PUBCHEM:5318517) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:30640040 + + a(PUBCHEM:5318517) association p(FPLX:NFkappaB) + + + + + + + pubmed:30640040 + + a(PUBCHEM:5318517) association p(FPLX:Actin) + + + + + + + pubmed:30640040 + + a(PUBCHEM:71295844) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:30640040 + + a(PUBCHEM:71295844) association p(HGNC:GSK3A) + + + + + + + pubmed:30640040 + + a(PUBCHEM:71295844) association p(HGNC:GSK3B) + + + + + + + pubmed:30640040 + + a(PUBCHEM:42640) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:30640040 + + a(PUBCHEM:42640) association p(HGNC:MDM4) + + + + + + + pubmed:30640040 + + a(PUBCHEM:2746) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:30640040 + + a(PUBCHEM:2746) association p(FPLX:"HDAC_I") + + + + + + + pubmed:30640040 + + a(PUBCHEM:71729974) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:30640040 + + a(PUBCHEM:71729974) association p(HGNCGENEFAMILY:"Lysine demethylases") + + + + + + + pubmed:30640040 + + a(PUBCHEM:11154925) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:30640040 + + a(PUBCHEM:11154925) association p(HGNC:KDR) + + + + + + + pubmed:30640040 + + a(PUBCHEM:4521392) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:30640040 + + a(PUBCHEM:4521392) association p(HGNC:TGFBR1) + + + + + + + pubmed:30640040 + + a(PUBCHEM:11234052) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:30640040 + + a(PUBCHEM:11234052) association p(HGNC:KDR) + + + + + + + pubmed:30640040 + + a(PUBCHEM:46209426) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:30640040 + + a(PUBCHEM:46209426) association p(FPLX:ROCK) + + + + + + + pubmed:30640040 + + a(PUBCHEM:6321424) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:30640040 + + a(PUBCHEM:6321424) increases act(p(HGNCGENEFAMILY:"Chloride channel accessory")) + + + + + + + pubmed:30640040 + + a(PUBCHEM:11570805) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:30640040 + + a(PUBCHEM:11570805) association p(HGNC:MAPK14) + + + + + + + pubmed:30640040 + + a(PUBCHEM:156422) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:30640040 + + a(PUBCHEM:156422) association p(HGNC:MAPK14) + + + + + + + pubmed:30640040 + + a(PUBCHEM:9880) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:30640040 + + a(PUBCHEM:9880) decreases act(p(HGNC:AR)) + + + + + + + pubmed:30640040 + + a(PUBCHEM:3033825) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:30640040 + + a(PUBCHEM:3033825) association p(HGNC:TNC) + + + + + + + pubmed:30640040 + + a(PUBCHEM:5311272) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:30640040 + + a(PUBCHEM:5311272) decreases act(p(FPLX:"Gamma_secretase")) + + + + + + + pubmed:30640040 + + a(PUBCHEM:49806720) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:30640040 + + a(PUBCHEM:49806720) decreases act(p(HGNC:ALK)) + + + + + + + pubmed:30640040 + + a(PUBCHEM:9839311) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:30640040 + + a(PUBCHEM:9839311) association p(HGNC:SELE) + + + + + + + pubmed:30640040 + + a(PUBCHEM:9839311) association p(HGNC:ICAM1) + + + + + + + pubmed:30640040 + + a(PUBCHEM:447966) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:30640040 + + a(PUBCHEM:447966) association p(HGNC:TGFBR1) + + + + + + + pubmed:30640040 + + a(PUBCHEM:11655119) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:30640040 + + a(PUBCHEM:11655119) association p(HGNC:TGFBR1) + + + + + + + pubmed:30640040 + + a(PUBCHEM:11655119) association p(HGNC:TGFBR2) + + + + + + + pubmed:30640040 + + a(PUBCHEM:10435235) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:30640040 + + a(PUBCHEM:10435235) decreases act(p(FPLX:"Gamma_secretase")) + + + + + + + pubmed:30640040 + + a(PUBCHEM:5833) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:30640040 + + a(PUBCHEM:5833) association p(HGNC:AR) + + + + + + + pubmed:30640040 + + a(PUBCHEM:10341154) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:30640040 + + a(PUBCHEM:10341154) association p(HGNC:MAPK14) + + + + + + + pubmed:30640040 + + a(PUBCHEM:4878) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:30640040 + + a(PUBCHEM:4878) association p(HGNC:LCK) + + + + + + + pubmed:30640040 + + a(PUBCHEM:4878) association p(HGNC:FYN) + + + + + + + pubmed:30640040 + + p(FPLX:"HDAC_I") association a(PUBCHEM:24756910) + + + + + + + pubmed:30640040 + + p(FPLX:"HDAC_I") association a(PUBCHEM:2746) + + + + + + + pubmed:30640040 + + p(FPLX:"HDAC_II") association a(PUBCHEM:24756910) + + + + + + + pubmed:30640040 + + p(HGNC:ERBB2) association a(PUBCHEM:24756910) + + + + + + + pubmed:30640040 + + p(FPLX:ESR) association a(PUBCHEM:448537) + + + + + + + pubmed:30640040 + + p(FPLX:Actin) association a(PUBCHEM:5318517) + + + + + + + + + pubmed:30640040 + + p(HGNC:MDM4) association a(PUBCHEM:42640) + + + + + + + pubmed:30640040 + + p(HGNCGENEFAMILY:"Lysine demethylases") association a(PUBCHEM:71729974) + + + + + + + pubmed:30640040 + + p(HGNC:TGFBR1) association a(PUBCHEM:4521392) + + + + + + + pubmed:30640040 + + p(HGNC:TGFBR1) association a(PUBCHEM:447966) + + + + + + + pubmed:30640040 + + p(HGNC:TGFBR1) association a(PUBCHEM:11655119) + + + + + + + pubmed:30640040 + + p(FPLX:ROCK) association a(PUBCHEM:46209426) + + + + + + + pubmed:30640040 + + p(HGNC:TNC) association a(PUBCHEM:3033825) + + + + + + + pubmed:30640040 + + p(HGNC:TGFBR2) association a(PUBCHEM:11655119) + + + + + + + pubmed:29191965 + + composite(a(MESH:"Amyloid beta-Peptides"), a(PUBCHEM:160718443)) decreases path(MESH:Paralysis) + + + + + + + + + + + + + pubmed:29191965 + + bp(GO:"cellular response to mechanical stimulus") decreases a(GO:"microtubule cytoskeleton") + + + + + + + pubmed:29191965 + + composite(p(HGNC:MAPT), p(HGNC:SPTB)) increases a(GO:"microtubule cytoskeleton") + + + + + + + + + pubmed:29191965 + + composite(p(HGNC:KLC3), p(HGNC:MAPT)) increases complex(p(HGNC:KLC3), p(HGNC:MAPT)) + + + + + + + + + + + pubmed:29191965 + + complex(p(HGNC:KLC3), p(HGNC:MAPT)) association a(GO:"synaptic vesicle") + + + + + + + pubmed:29191965 + + p(CONSO:"Tau isoform E (412 aa)", var("p.Pro301Leu")) decreases bp(GO:locomotion) + + + + + + + pubmed:29191965 + + p(CONSO:"Tau isoform E (412 aa)", var("p.Pro301Leu")) decreases a(MESH:Survival) + + + + + + + pubmed:29191965 + + p(CONSO:"Tau isoform E (412 aa)", var("p.Pro301Leu")) increases path(CONSO:Neurodegeneration) + + + + + + + pubmed:29191965 + + p(CONSO:"Tau isoform E (412 aa)", var("p.Pro301Leu")) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:29191965 + + p(CONSO:"Tau isoform E (412 aa)", var("p.Val337Met")) decreases bp(GO:locomotion) + + + + + + + pubmed:29191965 + + p(CONSO:"Tau isoform E (412 aa)", var("p.Val337Met")) decreases a(MESH:Survival) + + + + + + + pubmed:29191965 + + p(CONSO:"Tau isoform E (412 aa)", var("p.Val337Met")) increases path(CONSO:Neurodegeneration) + + + + + + + + + + + + + + + + + + + + + + + pubmed:29191965 + + p(CONSO:"Tau isoform D (383 aa)", var("p.Pro301Leu")) decreases act(a(MESH:Neurons)) + + + + + + + pubmed:29191965 + + p(CONSO:"Tau isoform D (383 aa)", var("p.Pro301Leu")) decreases act(a(MESH:Neurons)) + + + + + + + pubmed:29191965 + + p(CONSO:"Tau isoform D (383 aa)", var("p.Pro301Leu")) decreases a(GO:microtubule) + + + + + + + pubmed:29191965 + + p(CONSO:"Tau isoform D (383 aa)", var("p.Pro301Leu")) increases bp(GO:"neuron death") + + + + + + + pubmed:26458742 + + p(CONSO:"Tau isoform D (383 aa)", var("p.Pro301Leu")) positiveCorrelation p(CONSO:"Tau isoform D (383 aa)", pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) + + + + + + + pubmed:26458742 + + p(CONSO:"Tau isoform D (383 aa)", var("p.Pro301Leu")) positiveCorrelation p(CONSO:"Tau isoform D (383 aa)", pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) + + + + + + + pubmed:26458742 + + p(CONSO:"Tau isoform D (383 aa)", var("p.Pro301Leu")) positiveCorrelation p(CONSO:"Tau isoform D (383 aa)", pmod(go:0006468 ! "protein phosphorylation", Ser, 400)) + + + + + + + pubmed:26458742 + + p(CONSO:"Tau isoform D (383 aa)", var("p.Pro301Leu")) positiveCorrelation p(CONSO:"Tau isoform D (383 aa)", pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + + + + + + + pubmed:26458742 + + p(CONSO:"Tau isoform D (383 aa)", var("p.Pro301Leu")) positiveCorrelation p(CONSO:"Tau isoform D (383 aa)", pmod(go:0006468 ! "protein phosphorylation", Ser, 409)) + + + + + + + pubmed:26458742 + + p(CONSO:"Tau isoform D (383 aa)", var("p.Pro301Leu")) positiveCorrelation p(CONSO:"Tau isoform D (383 aa)", pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) + + + + + + + pubmed:26458742 + + p(CONSO:"Tau isoform D (383 aa)", var("p.Pro301Leu")) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:29191965 + + p(CONSO:"Tau isoform D (383 aa)", var("p.Arg406Trp")) decreases act(a(MESH:Neurons)) + + + + + + + pubmed:29191965 + + p(CONSO:"Tau isoform D (383 aa)", var("p.Arg406Trp")) decreases act(a(MESH:Neurons)) + + + + + + + pubmed:29191965 + + p(CONSO:"Tau isoform D (383 aa)", var("p.Arg406Trp")) decreases a(GO:microtubule) + + + + + + + pubmed:29191965 + + p(CONSO:"Tau isoform D (383 aa)", var("p.Arg406Trp")) increases bp(GO:"neuron death") + + + + + + + + + pubmed:29191965 + + p(CONSO:"Tau isoform Fetal-tau (352 aa)", pmod(CONSO:hyperphosphorylation)) decreases bp(GO:locomotion) + + + + + + + pubmed:29191965 + + p(CONSO:"Tau isoform Fetal-tau (352 aa)", pmod(CONSO:hyperphosphorylation)) decreases a(MESH:"Motor Neurons") + + + + + + + pubmed:29191965 + + composite(p(CONSO:"4R tau", var("p.Lys280del")), p(CONSO:"Tau isoform E (412 aa)", var("p.Val337Met"))) increases path(MESH:Paralysis) + + + + + + + pubmed:29191965 + + composite(p(CONSO:"4R tau", var("p.Lys280del")), p(CONSO:"Tau isoform E (412 aa)", var("p.Val337Met"))) decreases a(MESH:"GABAergic Neurons") + + + + + + + pubmed:29191965 + + composite(p(CONSO:"4R tau", var("p.Lys280del")), p(CONSO:"Tau isoform E (412 aa)", var("p.Val337Met"))) decreases a(MESH:"Cholinergic Neurons") + + + + + + + pubmed:29191965 + + composite(p(CONSO:"4R tau", var("p.Lys280del")), p(CONSO:"Tau isoform E (412 aa)", var("p.Val337Met"))) decreases a(GO:synapse) + + + + + + + pubmed:29191965 + + composite(p(CONSO:"4R tau", var("p.Lys280del")), p(CONSO:"Tau isoform E (412 aa)", var("p.Val337Met"))) decreases bp(GO:"axonal transport of mitochondrion") + + + + + + + + + + + pubmed:25374103 + + p(CONSO:"4R tau", var("p.Lys280del")) causesNoChange bp(GO:"cell death") + + + + + + + pubmed:25374103 + + p(CONSO:"4R tau", var("p.Lys280del")) decreases bp(GO:"mitochondrion transport along microtubule") + + + + + + + pubmed:25374103 + + p(CONSO:"4R tau", var("p.Lys280del")) decreases bp(GO:"mitochondrion transport along microtubule") + + + + + + + pubmed:29191965 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Ala152Thr")) increases path(MESH:Paralysis) + + + + + + + pubmed:29191965 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Ala152Thr")) decreases act(a(MESH:Neurons)) + + + + + + + pubmed:29191965 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Ala152Thr")) association bp(GO:"cell aging") + + + + + + + pubmed:29191965 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Ala152Thr")) decreases bp(MESH:Longevity) + + + + + + + pubmed:29191965 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Ala152Thr")) decreases bp(GO:"anterograde axonal transport of mitochondrion") + + + + + + + pubmed:29191965 + + bp(GO:"cell aging") association p(CONSO:"Tau isoform F (441 aa)", var("p.Ala152Thr")) + + + + + + + pubmed:29191965 + + complex(a(GO:"synaptic vesicle"), p(HGNC:MAPT)) decreases bp(MESH:"Synaptic Transmission") + + + + + + + pubmed:29191965 + + complex(a(GO:"synaptic vesicle"), p(HGNC:MAPT)) decreases act(a(GO:"synaptic vesicle")) + + + + + + + pubmed:29191965 + + composite(p(CONSO:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:CHRNA7)) decreases bp(GO:locomotion) + + + + + + + pubmed:29191965 + + composite(p(CONSO:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:BAIAP3)) decreases bp(GO:locomotion) + + + + + + + + + pubmed:29191965 + + p(HGNC:BAIAP3) regulates bp(GO:"retrograde trans-synaptic signaling") + + + + + + + pubmed:30985105 + + bp(GO:"musculoskeletal movement") association bp(GO:"dopamine secretion") + + + + + + + pubmed:29191965 + + a(GO:"cell body") association p(HGNC:MAPT) + + + + + + + pubmed:29191965 + + p(HGNC:PPP3CB) directlyDecreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:26631930 + + p(HGNC:PPP3CB) directlyDecreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:29191965 + + p(HGNC:PPP1R8) directlyDecreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:26631930 + + p(HGNC:PPP1R8) directlyDecreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:29191965 + + composite(p(CONSO:"Tau isoform D (383 aa)", var("p.Arg406Trp")), p(HGNC:CDK5)) decreases a(MESH:Neurons) + + + + + + + pubmed:29191965 + + a(PUBCHEM:6475963) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:29191965 + + a(PUBCHEM:6475963) increases bp(GO:locomotion) + + + + + + + pubmed:29191965 + + a(PUBCHEM:66766582) decreases path(CONSO:Neurodegeneration) + + + + + + + pubmed:29191965 + + a(CHEBI:azaperone) increases bp(GO:locomotion) + + + + + + + pubmed:29191965 + + a(CHEBI:azaperone) decreases p(HGNC:MAPT) + + + + + + + pubmed:29191965 + + a(CHEBI:azaperone) decreases path(CONSO:Neurodegeneration) + + + + + + + pubmed:29191965 + + a(CHEBI:ethosuximide) increases bp(MESH:Longevity) + + + + + + + pubmed:29191965 + + a(CHEBI:ethosuximide) increases bp(GO:locomotion) + + + + + + + pubmed:29191965 + + a(CHEBI:ethosuximide) association bp(GO:"insulin receptor signaling pathway") + + + + + + + pubmed:29191965 + + p(HGNC:WNT2) association path(MESH:Tauopathies) + + + + + + + pubmed:29191965 + + p(HGNC:TTBK2) association path(MESH:Tauopathies) + + + + + + + pubmed:17620722 + + p(HGNC:TTBK2) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 208)) + + + + + + + pubmed:17620722 + + p(HGNC:TTBK2) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 210)) + + + + + + + + + + + + + pubmed:25673844 + + p(HGNC:TTBK2) isA p(CONSO:"CK1 superfamily") + + + + + + + pubmed:25673844 + + p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(go:0006468 ! "protein phosphorylation", Ser, 42)) + + + + + + + pubmed:25673844 + + p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(go:0006468 ! "protein phosphorylation", Ser, 45)) + + + + + + + pubmed:25673844 + + p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(go:0006468 ! "protein phosphorylation", Ser, 47)) + + + + + + + pubmed:25673844 + + p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(go:0006468 ! "protein phosphorylation", Ser, 80)) + + + + + + + pubmed:25673844 + + p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(go:0006468 ! "protein phosphorylation", Ser, 81)) + + + + + + + pubmed:25673844 + + p(HGNC:TTBK2) increases p(HGNC:SV2A, pmod(go:0006468 ! "protein phosphorylation", Thr, 84)) + + + + + + + pubmed:25473830 + + p(HGNC:TTBK2) directlyIncreases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:25473830 + + p(HGNC:TTBK2) increases tloc(p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation")), fromLoc(GO:nucleus), toLoc(GO:cytoplasm)) + + + + + + + pubmed:27607061 + + p(HGNC:TTBK2) decreases tloc(p(HGNC:GRIK2), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) + + + + + + + + + + + pubmed:23942339 + + p(HGNC:TTBK2) increases act(p(HGNC:SLC6A12)) + + + + + + + pubmed:22814243 + + p(HGNC:TTBK2) increases act(p(HGNC:SLC5A1)) + + + + + + + pubmed:25297623 + + p(HGNC:TTBK2) association p(HGNC:CEP164) + + + + + + + pubmed:25297623 + + p(HGNC:TTBK2) association p(HGNC:MAPRE1) + + + + + + + + + pubmed:25297623 + + act(p(HGNC:TTBK2)) increases deg(p(HGNC:CCP110)) + + + + + + + pubmed:25297623 + + act(p(HGNC:TTBK2)) increases p(HGNC:CEP164, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:25297623 + + act(p(HGNC:TTBK2)) increases p(HGNC:CEP97, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:25297623 + + act(p(HGNC:TTBK2)) increases bp(GO:"cytosolic ciliogenesis") + + + + + + + pubmed:29191965 + + p(HGNC:TAOK1) association path(MESH:Tauopathies) + + + + + + + pubmed:25974414 + + act(p(HGNC:TAOK1), ma(go:0016301 ! "kinase activity")) directlyIncreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:29191965 + + p(HGNC:CTSE) association path(MESH:Tauopathies) + + + + + + + + + pubmed:29191965 + + p(HGNC:DNMBP) increases complex(p(HGNC:DNMBP), p(HGNC:ENAH)) + + + + + + + + + + + pubmed:29191965 + + composite(p(CONSO:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:DNMBP)) increases path(MESH:Tauopathies) + + + + + + + pubmed:29191965 + + p(HGNC:ZC3H14) decreases bp(GO:locomotion) + + + + + + + pubmed:29191965 + + p(HGNC:ZC3H14) increases path(CONSO:Neurodegeneration) + + + + + + + pubmed:29191965 + + p(HGNC:ZC3H14) increases p(HGNC:MAPT) + + + + + + + pubmed:29191965 + + p(HGNC:ZC3H14) increases path(MESH:Tauopathies) + + + + + + + pubmed:29191965 + + p(HGNC:ZC3H14) regulates bp(GO:"aggresome assembly") + + + + + + + pubmed:29191965 + + bp(GO:"aggresome assembly") association path(MESH:"Neurodegenerative Diseases") + + + + + + + pubmed:29191965 + + bp(GO:"aggresome assembly") decreases p(MESH:Proteins, pmod(CONSO:misfolding)) + + + + + + + pubmed:29191965 + + p(HGNC:DDC) increases a(CHEBI:dopamine) + + + + + + + pubmed:29191965 + + p(HGNC:DDC) increases a(CHEBI:serotonin) + + + + + + + + + pubmed:29191965 + + composite(p(CONSO:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:DDC)) decreases bp(GO:locomotion) + + + + + + + pubmed:29191965 + + composite(p(CONSO:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:DDC)) increases p(HGNC:MAPT) + + + + + + + pubmed:29191965 + + composite(p(CONSO:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:DDC)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:29191965 + + composite(p(CONSO:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:DDC)) increases path(CONSO:Neurodegeneration) + + + + + + + pubmed:29191965 + + composite(p(CONSO:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:TH)) causesNoChange path(MESH:Tauopathies) + + + + + + + pubmed:29191965 + + p(HGNC:GCH1) regulates a(CHEBI:dopamine) + + + + + + + pubmed:29191965 + + p(HGNC:GCH1) regulates a(CHEBI:serotonin) + + + + + + + pubmed:29191965 + + p(HGNC:GCH1) regulates act(p(HGNC:DDC)) + + + + + + + + + pubmed:29191965 + + composite(p(CONSO:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:GCH1)) causesNoChange path(MESH:Tauopathies) + + + + + + + pubmed:29191965 + + p(HGNC:TPH1) regulates a(CHEBI:dopamine) + + + + + + + pubmed:29191965 + + p(HGNC:TPH1) regulates a(CHEBI:serotonin) + + + + + + + pubmed:29191965 + + p(HGNC:TPH1) regulates act(p(HGNC:DDC)) + + + + + + + + + pubmed:29191965 + + composite(p(CONSO:"Tau isoform E (412 aa)", var("p.Val337Met")), p(HGNC:TPH1)) causesNoChange path(MESH:Tauopathies) + + + + + + + pubmed:29686391 + + tloc(a(CONSO:"sonicated tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) positiveCorrelation a(CONSO:"sonicated tau fibrils") + + + + + + + pubmed:29686391 + + a(CONSO:"sonicated tau fibrils") positiveCorrelation tloc(a(CONSO:"sonicated tau fibrils"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:29686391 + + g(HGNC:TP53) increases bp(GO:"mitotic G1 phase") + + + + + + + pubmed:29686391 + + g(HGNC:TP53) decreases bp(GO:"cell proliferation") + + + + + + + pubmed:29686391 + + bp(GO:"mitotic G1 phase") positiveCorrelation bp(GO:endocytosis) + + + + + + + pubmed:29686391 + + bp(GO:"mitotic G1 phase") regulates tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:29686391 + + p(HGNC:CDK6) decreases tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:18305152 + + p(HGNC:CDK6) association act(p(HGNC:RB1)) + + + + + + + pubmed:18305152 + + p(HGNC:CDK6) regulates bp(GO:"cell cycle") + + + + + + + + + + + + + + + + + + + + + + + + + pubmed:18305152 + + act(p(HGNC:CDK6)) regulates bp(GO:"cell differentiation") + + + + + + + pubmed:18305152 + + p(HGNC:CDK6) association path(EFO:neoplasm) + + + + + + + pubmed:18305152 + + p(HGNC:CDK6) directlyIncreases p(HGNC:RB1, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:29686391 + + a(CHEBI:palbociclib) increases tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:29686391 + + a(CHEBI:palbociclib) decreases act(p(HGNC:CDK4)) + + + + + + + pubmed:29686391 + + a(CHEBI:palbociclib) decreases act(p(HGNC:CDK6)) + + + + + + + pubmed:29686391 + + p(HGNC:EXT2) association bp(GO:"heparan sulfate proteoglycan biosynthetic process") + + + + + + + pubmed:29686391 + + p(HGNC:EXT2) increases tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:29686391 + + p(HGNC:EXT2) increases tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:29686391 + + p(HGNC:EXT2) increases tloc(a(CONSO:"Tau oligomers"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:29686391 + + bp(GO:"heparan sulfate proteoglycan biosynthetic process") association p(HGNC:EXT2) + + + + + + + pubmed:29686391 + + bp(GO:"heparan sulfate proteoglycan biosynthetic process") association p(HGNC:HS6ST1) + + + + + + + pubmed:29686391 + + p(HGNC:HS6ST1) association bp(GO:"heparan sulfate proteoglycan biosynthetic process") + + + + + + + pubmed:29686391 + + p(HGNC:HS6ST1) increases tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:29686391 + + p(HGNC:HS6ST1) increases tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:29686391 + + p(HGNC:HS6ST1) increases tloc(a(CONSO:"Tau oligomers"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:29686391 + + p(HGNC:HS6ST1) increases a(CONSO:"6-O-sulfated heparin") + + + + + + + pubmed:29686391 + + p(HGNC:DNM2) increases tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:29686391 + + p(HGNC:DNM2) increases tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:29686391 + + p(HGNC:DNM2) increases tloc(a(CONSO:"Tau oligomers"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + + + pubmed:29686391 + + a(CONSO:"6-O-sulfated heparin") increases complex(a(CONSO:"6-O-sulfated heparin"), p(CONSO:"Tau isoform F (441 aa)")) + + + + + + + pubmed:29686391 + + a(CONSO:"6-O-sulfated heparin") decreases tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:29686391 + + a(CONSO:"6-O-sulfated heparin") positiveCorrelation tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:29686391 + + a(CONSO:"6-O-sulfated heparin") increases tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + + + pubmed:29980653 + + a(CONSO:"6-O-sulfated heparin") increases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:29686391 + + a(CONSO:"2-O-sulfated heparin") decreases tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:29686391 + + a(CONSO:"2-O-sulfated heparin") decreases tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:29686391 + + a(CHEBI:"chondroitin sulfate") decreases tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:29686391 + + a(CHEBI:"chondroitin sulfate") increases tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:29686391 + + a(MESH:"Heparitin Sulfate") decreases tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:29686391 + + p(HGNC:SULF1) decreases tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:29686391 + + p(HGNC:SULF1) decreases tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:29686391 + + p(HGNC:SULF1) decreases tloc(p(CONSO:"6-O-sulfated heparin"), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) + + + + + + + pubmed:29686391 + + p(HGNC:SULF2) decreases tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:29686391 + + p(HGNC:SULF2) decreases tloc(p(CONSO:"Tau isoform F (441 aa)"), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:29686391 + + p(HGNC:SULF2) decreases tloc(p(CONSO:"6-O-sulfated heparin"), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) + + + + + + + pubmed:30985105 + + p(HGNC:OGT) increases p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) + + + + + + + pubmed:30985105 + + p(HGNC:OGT) increases p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) + + + + + + + pubmed:30985105 + + act(p(HGNC:OGT)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:30985105 + + act(p(HGNC:OGT)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:30985105 + + act(p(HGNC:OGT)) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:30985105 + + act(p(HGNC:OGT)) increases p(HGNC:MAPT, pmod(CONSO:O-GlcNAcylation)) + + + + + + + pubmed:30985105 + + act(p(HGNC:OGT)) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:30985105 + + p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) association bp(GO:"cellular glucose homeostasis") + + + + + + + pubmed:30985105 + + p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) positiveCorrelation a(CHEBI:glucose) + + + + + + + pubmed:30985105 + + p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) negativeCorrelation act(p(HGNC:OGA)) + + + + + + + pubmed:30985105 + + p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) association bp(GO:"protein phosphorylation") + + + + + + + pubmed:30985105 + + p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) association bp(GO:"protein phosphorylation") + + + + + + + pubmed:30985105 + + p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) association bp(GO:"glucose metabolic process") + + + + + + + pubmed:30985105 + + p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) negativeCorrelation deg(a(GO:"neurofibrillary tangle")) + + + + + + + pubmed:19732809 + + p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) negativeCorrelation path(MESH:"Cardiovascular Diseases") + + + + + + + pubmed:19732809 + + p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:19732809 + + p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) negativeCorrelation path(MESH:"Diabetes Mellitus, Type 2") + + + + + + + pubmed:19732809 + + p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) association bp(MESH:"Hot Temperature") + + + + + + + pubmed:19732809 + + p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) decreases act(complex(GO:"proteasome complex")) + + + + + + + pubmed:30985105 + + p(HGNC:OGA) increases p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) + + + + + + + pubmed:30985105 + + act(p(HGNC:OGA)) negativeCorrelation p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) + + + + + + + pubmed:30985105 + + p(HGNC:OGA) association bp(GO:"brain development") + + + + + + + pubmed:30985105 + + act(p(HGNC:OGA)) decreases p(HGNC:MTOR, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:30985105 + + act(p(HGNC:OGA)) decreases p(FPLX:AKT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:30985105 + + act(p(HGNC:OGA)) decreases bp(GO:autophagy) + + + + + + + pubmed:30985105 + + act(p(HGNC:OGA)) decreases p(HGNC:HTT, var("?")) + + + + + + + pubmed:30985105 + + bp(GO:"cellular glucose homeostasis") association p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) + + + + + + + pubmed:30985105 + + a(PUBCHEM:9576811) decreases act(p(HGNC:OGA)) + + + + + + + pubmed:30985105 + + a(PUBCHEM:9576811) decreases act(p(HGNC:OGA)) + + + + + + + pubmed:30985105 + + a(PUBCHEM:9576811) decreases act(a(MESH:Hexosaminidases)) + + + + + + + pubmed:30985105 + + a(PUBCHEM:9576811) increases p(HGNC:APP, pmod(CONSO:O-GlcNAcylation)) + + + + + + + pubmed:30985105 + + a(PUBCHEM:9576811) increases p(HGNC:APP, pmod(CONSO:O-GlcNAcylation)) + + + + + + + pubmed:30985105 + + a(PUBCHEM:9576811) increases tloc(p(CONSO:sAPP-alpha), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:30985105 + + a(PUBCHEM:9576811) decreases tloc(a(CHEBI:"amyloid-beta polypeptide 40"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:30985105 + + a(PUBCHEM:9576811) increases tloc(p(HGNC:APP), fromLoc(GO:"trans-Golgi network"), toLoc(GO:"plasma membrane")) + + + + + + + pubmed:30985105 + + a(PUBCHEM:9576811) decreases tloc(p(HGNC:APP), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) + + + + + + + pubmed:30985105 + + a(PUBCHEM:9576811) increases bp(CONSO:"APP processing") + + + + + + + pubmed:30985105 + + a(PUBCHEM:135566354) increases tloc(a(PUBCHEM:135566354), fromLoc(MESH:Blood), toLoc(MESH:Brain)) + + + + + + + pubmed:30985105 + + a(PUBCHEM:135566354) decreases act(p(HGNC:OGA)) + + + + + + + pubmed:30985105 + + a(PUBCHEM:135566354) decreases act(p(HGNC:OGA)) + + + + + + + pubmed:30985105 + + a(PUBCHEM:135566354) increases p(HGNC:MTOR, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:30985105 + + a(PUBCHEM:135566354) increases p(FPLX:AKT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:30985105 + + a(PUBCHEM:135566354) increases p(HGNC:SNCA) + + + + + + + pubmed:30985105 + + a(PUBCHEM:135566354) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) + + + + + + + pubmed:30985105 + + a(PUBCHEM:135566354) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) + + + + + + + pubmed:30985105 + + a(PUBCHEM:135566354) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:30985105 + + a(PUBCHEM:135566354) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:30985105 + + a(PUBCHEM:135566354) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:30985105 + + a(PUBCHEM:135566354) decreases a(CONSO:"Tau aggregates", loc(MESH:Brain)) + + + + + + + pubmed:30985105 + + a(PUBCHEM:135566354) decreases p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) + + + + + + + pubmed:30985105 + + a(PUBCHEM:135566354) decreases p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) + + + + + + + pubmed:30985105 + + a(PUBCHEM:135566354) decreases p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) + + + + + + + pubmed:30985105 + + a(PUBCHEM:135566354) increases p(MGI:Mapt, pmod(CONSO:O-GlcNAcylation)) + + + + + + + pubmed:30985105 + + a(PUBCHEM:135566354) increases p(MGI:Mapt, pmod(CONSO:O-GlcNAcylation)) + + + + + + + pubmed:30985105 + + a(PUBCHEM:135566354) decreases bp(GO:"neuron death") + + + + + + + pubmed:30985105 + + a(PUBCHEM:135566354) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Ser, 205)) + + + + + + + pubmed:30985105 + + a(PUBCHEM:135566354) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 626)) + + + + + + + pubmed:30985105 + + a(PUBCHEM:135566354) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) + + + + + + + pubmed:30985105 + + a(PUBCHEM:135566354) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) + + + + + + + pubmed:30985105 + + a(PUBCHEM:135566354) causesNoChange p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 400)) + + + + + + + pubmed:30985105 + + a(PUBCHEM:135566354) decreases p(HGNC:MAPT, loc(MESH:"Cerebrospinal Fluid")) + + + + + + + pubmed:30985105 + + a(PUBCHEM:135566354) increases bp(GO:cognition) + + + + + + + pubmed:30985105 + + a(PUBCHEM:135566354) decreases a(CHEBI:amyloid-beta) + + + + + + + pubmed:30985105 + + a(PUBCHEM:135566354) decreases path(MESH:"Plaque, Amyloid") + + + + + + + pubmed:30985105 + + a(PUBCHEM:135566354) causesNoChange p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:30985105 + + deg(a(CONSO:"Dopaminergic cell groups")) positiveCorrelation path(MESH:"Parkinson Disease") + + + + + + + pubmed:30985105 + + deg(a(CONSO:"Dopaminergic cell groups")) negativeCorrelation bp(GO:"motor behavior") + + + + + + + pubmed:30985105 + + complex(p(HGNC:SNCA), p(HGNC:SNCA)) association path(MESH:"Parkinson Disease") + + + + + + + pubmed:30985105 + + complex(a(CHEBI:phospholipid), p(HGNC:SNCA)) increases bp(GO:"SNARE complex assembly") + + + + + + + + + pubmed:30985105 + + complex(p(HGNC:SNCA), p(HGNC:VAMP2)) increases bp(GO:"SNARE complex assembly") + + + + + + + + + + + pubmed:30985105 + + p(HGNC:SNCA, frag("?_*")) increases a(CONSO:"alpha-synuclein aggregates") + + + + + + + pubmed:30985105 + + p(CONSO:"alpha-synuclein fibrils", frag("?")) increases a(CONSO:"alpha-synuclein aggregates") + + + + + + + pubmed:30985105 + + p(HGNC:SNCA, pmod(CONSO:O-GlcNAcylation)) decreases a(CONSO:"alpha-synuclein aggregates") + + + + + + + pubmed:30985105 + + p(HGNC:SNCA, pmod(CONSO:O-GlcNAcylation)) increases a(CONSO:"alpha-synuclein oligomers") + + + + + + + pubmed:30985105 + + p(HGNC:SNCA, pmod(CONSO:O-GlcNAcylation, Thr, 72)) decreases complex(p(HGNC:SNCA), p(HGNC:SNCA)) + + + + + + + pubmed:30985105 + + p(HGNC:SNCA, pmod(CONSO:O-GlcNAcylation, Thr, 72)) decreases a(CONSO:"alpha-synuclein aggregates") + + + + + + + pubmed:30985105 + + p(HGNC:SNCA, pmod(CONSO:O-GlcNAcylation, Thr, 72)) increases a(CONSO:"alpha-synuclein fibrils") + + + + + + + pubmed:30985105 + + p(HGNC:SNCA, pmod(CONSO:O-GlcNAcylation, Ser, 87)) increases a(CONSO:"alpha-synuclein fibrils") + + + + + + + pubmed:30985105 + + p(HGNC:SNCA, pmod(CONSO:O-GlcNAcylation, Thr, 75)) increases a(CONSO:"alpha-synuclein aggregates") + + + + + + + pubmed:30985105 + + p(HGNC:SNCA, pmod(CONSO:O-GlcNAcylation, Thr, 81)) increases a(CONSO:"alpha-synuclein aggregates") + + + + + + + pubmed:30985105 + + p(HGNC:SNCA, pmod(CONSO:O-GlcNAcylation, Ser, 87), pmod(CONSO:O-GlcNAcylation, Thr, 72), pmod(CONSO:O-GlcNAcylation, Thr, 81)) causesNoChange a(CONSO:"alpha-synuclein aggregates") + + + + + + + pubmed:30985105 + + p(HGNC:SNCA, frag("68_77")) increases a(CONSO:"alpha-synuclein aggregates") + + + + + + + pubmed:30985105 + + p(HGNC:SNCA, frag("68_77"), pmod(CONSO:O-GlcNAcylation)) increases a(CONSO:"alpha-synuclein aggregates") + + + + + + + pubmed:30985105 + + p(HGNC:MTOR, pmod(go:0006468 ! "protein phosphorylation")) decreases bp(GO:autophagy) + + + + + + + pubmed:30985105 + + act(p(MGI:Oga)) decreases bp(GO:autophagy) + + + + + + + pubmed:30985105 + + act(p(RGD:Oga)) decreases bp(GO:autophagy) + + + + + + + pubmed:30985105 + + p(RGD:Mapt, pmod(CONSO:O-GlcNAcylation)) negativeCorrelation p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:30985105 + + p(MGI:Mapt, pmod(CONSO:O-GlcNAcylation)) negativeCorrelation p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:30985105 + + p(HGNC:MAPT, pmod(CONSO:O-GlcNAcylation)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:16630055 + + p(HGNC:MAPT, pmod(CONSO:O-GlcNAcylation)) negativeCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:30985105 + + p(HGNC:MAPT, pmod(CONSO:O-GlcNAcylation)) decreases a(CONSO:"Tau oligomers") + + + + + + + pubmed:30985105 + + p(HGNC:MAPT, pmod(CONSO:O-GlcNAcylation)) decreases a(CONSO:"Tau oligomers") + + + + + + + pubmed:22833681 + + p(HGNC:MAPT, pmod(CONSO:O-GlcNAcylation)) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) + + + + + + + pubmed:22833681 + + p(HGNC:MAPT, pmod(CONSO:O-GlcNAcylation)) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) + + + + + + + pubmed:22833681 + + p(HGNC:MAPT, pmod(CONSO:O-GlcNAcylation)) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) + + + + + + + pubmed:22833681 + + p(HGNC:MAPT, pmod(CONSO:O-GlcNAcylation)) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) + + + + + + + pubmed:22833681 + + p(HGNC:MAPT, pmod(CONSO:O-GlcNAcylation)) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) + + + + + + + pubmed:22833681 + + p(HGNC:MAPT, pmod(CONSO:O-GlcNAcylation)) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:19732809 + + p(HGNC:MAPT, pmod(CONSO:O-GlcNAcylation)) negativeCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:30985105 + + p(CONSO:"Tau isoform F (441 aa)", pmod(CONSO:O-GlcNAcylation)) decreases a(CONSO:"Tau oligomers") + + + + + + + pubmed:30985105 + + p(HGNC:MAPT, pmod(CONSO:O-GlcNAcylation, Ser, 400)) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:30985105 + + p(CONSO:"VQIVYK motif", pmod(CONSO:O-GlcNAcylation)) decreases complex(p(CONSO:"VQIVYK motif"), p(CONSO:"VQIVYK motif")) + + + + + + + pubmed:30985105 + + p(CONSO:"VQIVYK motif", pmod(CONSO:O-GlcNAcylation)) decreases a(CONSO:"Tau fibrils") + + + + + + + + + + + pubmed:26631930 + + p(CONSO:"VQIVYK motif") increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:26631930 + + p(CONSO:"VQIVYK motif") increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:26631930 + + p(CONSO:"VQIVYK motif") increases a(CONSO:"Tau fibrils") + + + + + + + pubmed:17493042 + + p(CONSO:"VQIVYK motif") partOf p(CONSO:"tubulin-binding repeat 3") + + + + + + + pubmed:17493042 + + p(CONSO:"VQIVYK motif") increases p(CONSO:"paired helical filaments") + + + + + + + pubmed:17493042 + + p(CONSO:"VQIVYK motif") increases bp(GO:"neurofibrillary tangle assembly") + + + + + + + pubmed:19363271 + + p(CONSO:"VQIVYK motif") association p(FPLX:HSP90) + + + + + + + pubmed:19363271 + + p(CONSO:"VQIVYK motif") isA p(CONSO:"tubulin-binding repeat 4") + + + + + + + pubmed:19363271 + + p(CONSO:"VQIVYK motif") increases complex(p(FPLX:HSP90), p(HGNC:MAPT)) + + + + + + + pubmed:28002468 + + p(CONSO:"VQIVYK motif") equivalentTo p(HGNC:MAP2, frag("332_339")) + + + + + + + pubmed:11606569 + + p(CONSO:"VQIVYK motif") positiveCorrelation p(HGNC:MAPT, var("p.Lys280del")) + + + + + + + pubmed:11606569 + + p(CONSO:"VQIVYK motif") positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) + + + + + + + pubmed:11606569 + + p(CONSO:"VQIVYK motif") increases p(CONSO:"Tau aggregates") + + + + + + + pubmed:26903089 + + p(CONSO:"VQIVYK motif") association act(p(HGNC:FKBP4)) + + + + + + + pubmed:30985105 + + p(HGNC:APP, pmod(CONSO:O-GlcNAcylation)) negativeCorrelation a(CHEBI:amyloid-beta) + + + + + + + pubmed:30985105 + + p(HGNC:APP, pmod(CONSO:O-GlcNAcylation)) increases p(HGNC:APP, pmod(CONSO:O-GlcNAcylation), loc(GO:"plasma membrane")) + + + + + + + pubmed:30985105 + + p(HGNC:APP, pmod(CONSO:O-GlcNAcylation), loc(GO:"plasma membrane")) increases bp(CONSO:"APP processing") + + + + + + + pubmed:30985105 + + a(MESH:"1,2-dideoxy-2'-propylglucopyranoso(2,1-d)-delta 2'-thiazoline") decreases act(p(HGNC:OGA)) + + + + + + + pubmed:30985105 + + a(MESH:"1,2-dideoxy-2'-propylglucopyranoso(2,1-d)-delta 2'-thiazoline") decreases a(CHEBI:amyloid-beta) + + + + + + + pubmed:30985105 + + a(MESH:"1,2-dideoxy-2'-propylglucopyranoso(2,1-d)-delta 2'-thiazoline") decreases path(MESH:Gliosis) + + + + + + + pubmed:30985105 + + a(MESH:"1,2-dideoxy-2'-propylglucopyranoso(2,1-d)-delta 2'-thiazoline") increases p(MGI:Sod1, pmod(CONSO:O-GlcNAcylation)) + + + + + + + pubmed:30985105 + + a(CHEBI:"prostaglandin J2") regulates path(MESH:Inflammation) + + + + + + + pubmed:30985105 + + a(CHEBI:"prostaglandin J2") increases p(HGNC:APP, frag("?")) + + + + + + + pubmed:30985105 + + a(CHEBI:"prostaglandin J2") increases p(HGNC:APP, pmod(CONSO:O-GlcNAcylation)) + + + + + + + pubmed:30985105 + + bp(GO:"vesicle transport along microtubule") association p(HGNC:HTT) + + + + + + + pubmed:30985105 + + p(HGNC:HTT, pmod(CONSO:O-GlcNAcylation)) increases a(CONSO:"huntingtin aggregates") + + + + + + + pubmed:30985105 + + p(HGNC:HTT, pmod(CONSO:O-GlcNAcylation)) decreases deg(a(CONSO:"huntingtin aggregates")) + + + + + + + pubmed:30985105 + + p(HGNC:HTT, pmod(CONSO:O-GlcNAcylation)) decreases act(a(GO:autophagosome)) + + + + + + + pubmed:30985105 + + p(HGNC:HTT, pmod(CONSO:O-GlcNAcylation)) decreases bp(GO:autophagy) + + + + + + + pubmed:30985105 + + p(MGI:Sod1, var("?")) decreases p(MGI:Sod1, pmod(CONSO:O-GlcNAcylation)) + + + + + + + + + + + pubmed:25374103 + + p(MGI:Stub1) decreases act(p(MGI:Casp3)) + + + + + + + pubmed:25374103 + + p(MGI:Stub1) decreases p(CONSO:"Tau C3") + + + + + + + pubmed:29311797 + + p(MGI:Stub1) increases deg(p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation"))) + + + + + + + pubmed:29311797 + + p(MGI:Stub1) increases deg(p(MGI:Mapt, pmod(CONSO:misfolded))) + + + + + + + pubmed:25374103 + + composite(p(CONSO:"Tau C3"), p(HGNC:STUB1)) increases complex(p(CONSO:"Tau C3"), p(HGNC:STUB1)) + + + + + + + pubmed:25374103 + + composite(p(CONSO:"Tau C3"), p(HGNC:STUB1)) increases complex(p(CONSO:"Tau C3"), p(HGNC:STUB1)) + + + + + + + pubmed:25374103 + + composite(p(CONSO:"Tau C3"), p(HGNC:STUB1)) decreases p(CONSO:"Tau C3") + + + + + + + pubmed:25374103 + + composite(p(CONSO:"Tau C3"), p(HGNC:STUB1)) causesNoChange a(MESH:"HSP70 Heat-Shock Proteins") + + + + + + + pubmed:25374103 + + composite(p(CONSO:"Tau C3"), p(HGNC:STUB1)) decreases p(HGNC:CASP3, frag("?")) + + + + + + + pubmed:25374103 + + composite(p(CONSO:"Tau C3"), p(HGNC:STUB1)) increases bp(GO:"mitochondrion transport along microtubule") + + + + + + + pubmed:25374103 + + composite(p(CONSO:"Tau C3"), p(HGNC:STUB1)) increases bp(GO:"mitochondrion transport along microtubule") + + + + + + + pubmed:25374103 + + composite(p(CONSO:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) decreases p(CONSO:"Tau isoform F (441 aa)") + + + + + + + pubmed:25374103 + + composite(p(CONSO:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) decreases p(HGNC:CASP3, frag("?")) + + + + + + + pubmed:25374103 + + composite(p(CONSO:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) increases complex(p(CONSO:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) + + + + + + + pubmed:25374103 + + composite(p(CONSO:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) decreases p(CONSO:"Tau C3") + + + + + + + pubmed:25374103 + + composite(p(CONSO:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) increases bp(GO:"mitochondrion transport along microtubule") + + + + + + + pubmed:25374103 + + composite(p(CONSO:"Tau isoform F (441 aa)"), p(HGNC:STUB1)) increases bp(GO:"mitochondrion transport along microtubule") + + + + + + + pubmed:25374103 + + composite(p(CONSO:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) decreases p(CONSO:"4R tau", var("p.Lys280del")) + + + + + + + pubmed:25374103 + + composite(p(CONSO:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) decreases p(CONSO:"4R tau", var("p.Lys280del")) + + + + + + + pubmed:25374103 + + composite(p(CONSO:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) negativeCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) + + + + + + + pubmed:25374103 + + composite(p(CONSO:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) causesNoChange a(MESH:"HSP70 Heat-Shock Proteins") + + + + + + + pubmed:25374103 + + composite(p(CONSO:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) increases bp(GO:"mitochondrion transport along microtubule") + + + + + + + pubmed:25374103 + + composite(p(CONSO:"4R tau", var("p.Lys280del")), p(HGNC:STUB1)) increases bp(GO:"mitochondrion transport along microtubule") + + + + + + + pubmed:25374103 + + composite(p(FPLX:HSP90), p(HGNC:STUB1)) increases complex(p(FPLX:HSP90), p(HGNC:STUB1)) + + + + + + + pubmed:25374103 + + composite(a(MESH:"HSP70 Heat-Shock Proteins"), p(HGNC:STUB1)) increases complex(a(MESH:"HSP70 Heat-Shock Proteins"), p(HGNC:STUB1)) + + + + + + + pubmed:25374103 + + complex(a(MESH:"HSP70 Heat-Shock Proteins"), p(HGNC:STUB1)) increases complex(a(MESH:"HSP70 Heat-Shock Proteins"), p(HGNC:STUB1), p(MESH:Proteins, pmod(CONSO:misfolded))) + + + + + + + pubmed:25374103 + + composite(p(CONSO:"4R tau"), p(HGNC:STUB1)) increases a(MESH:"HSP70 Heat-Shock Proteins") + + + + + + + pubmed:25374103 + + p(PFAM:"CHIP_TPR_N") increases complex(a(MESH:"HSP70 Heat-Shock Proteins"), p(FPLX:HSP90), p(HGNC:STUB1)) + + + + + + + pubmed:25374103 + + complex(p(HGNC:STUB1), p(INTERPRO:"U box domain")) increases p(CONSO:"Tau isoform F (441 aa)") + + + + + + + pubmed:25374103 + + complex(p(HGNC:STUB1), p(INTERPRO:"U box domain")) increases p(CONSO:"4R tau", var("p.Lys280del")) + + + + + + + pubmed:28877763 + + act(p(MGI:Syk)) positiveCorrelation bp(GO:"microglial cell activation") + + + + + + + + + pubmed:28877763 + + act(p(MGI:Syk)) positiveCorrelation a(CONSO:"amyloid-beta aggregates") + + + + + + + pubmed:28877763 + + act(p(MGI:Syk)) positiveCorrelation a(MESH:Neurites) + + + + + + + + + + + pubmed:28877763 + + p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) + + + + + + + pubmed:25331948 + + p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) + + + + + + + pubmed:28877763 + + p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) + + + + + + + pubmed:25331948 + + p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) + + + + + + + pubmed:28877763 + + p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + + + + + + + pubmed:25331948 + + p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + + + + + + + pubmed:28877763 + + p(MGI:Syk) positiveCorrelation p(MGI:Mapt) + + + + + + + pubmed:25331948 + + p(MGI:Syk) increases a(CHEBI:amyloid-beta) + + + + + + + pubmed:25331948 + + p(MGI:Syk) decreases deg(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:25331948 + + p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) + + + + + + + pubmed:28877763 + + p(MGI:Syk, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation bp(GO:"microglial cell activation") + + + + + + + pubmed:28877763 + + p(MGI:Syk, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation a(CONSO:"amyloid-beta aggregates") + + + + + + + pubmed:28877763 + + p(MGI:Syk, pmod(go:0006468 ! "protein phosphorylation")) partOf a(CONSO:"dystrophic neurite") + + + + + + + pubmed:28877763 + + p(MGI:Syk, pmod(go:0006468 ! "protein phosphorylation")) increases act(p(MGI:Syk)) + + + + + + + pubmed:28877763 + + p(MGI:Syk, pmod(go:0006468 ! "protein phosphorylation", Tyr, 525)) association a(CONSO:"Tau aggregates") + + + + + + + pubmed:28877763 + + p(MGI:Syk, pmod(go:0006468 ! "protein phosphorylation", Tyr, 526)) association a(CONSO:"Tau aggregates") + + + + + + + pubmed:28877763 + + p(HGNC:SYK, pmod(go:0006468 ! "protein phosphorylation")) association a(CONSO:"Tau aggregates") + + + + + + + pubmed:28877763 + + p(HGNC:SYK, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation a(CONSO:"Tau aggregates") + + + + + + + pubmed:28877763 + + p(HGNC:SYK, pmod(go:0006468 ! "protein phosphorylation")) association p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) + + + + + + + pubmed:28877763 + + p(HGNC:SYK, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) + + + + + + + pubmed:28877763 + + p(HGNC:SYK, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) + + + + + + + pubmed:28877763 + + p(HGNC:SYK, pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation path(MESH:"Plaque, Amyloid") + + + + + + + pubmed:28420982 + + a(CONSO:"granular tau oligomers") increases a(CONSO:"Tau fibrils") + + + + + + + pubmed:28420982 + + a(MESH:Exosomes) association tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:29238289 + + act(a(MESH:Exosomes)) association p(HGNC:MAPT) + + + + + + + pubmed:28420982 + + a(MESH:Exosomes) association path(MESH:"Plaque, Amyloid") + + + + + + + pubmed:28420982 + + a(MESH:Exosomes) association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 181)) + + + + + + + pubmed:28420982 + + a(GO:microvesicle) association tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:28420982 + + a(GO:microvesicle) regulates tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:28420982 + + complex(a(GO:vesicle), a(MESH:"Cell Membrane")) increases tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + + + pubmed:28420982 + + complex(p(HGNC:CHRM1), p(HGNC:MAPT)) increases path(MESH:Tauopathies) + + + + + + + pubmed:28420982 + + complex(p(HGNC:CHRM3), p(HGNC:MAPT)) increases path(MESH:Tauopathies) + + + + + + + pubmed:28420982 + + complex(a(CONSO:"Tau aggregates"), a(MESH:"Heparan Sulfate Proteoglycans")) increases tloc(a(CONSO:"Tau aggregates"), fromLoc(GO:"extracellular space"), toLoc(GO:"intracellular part")) + + + + + + + pubmed:28420982 + + complex(a(CONSO:"Tau aggregates"), a(MESH:"Heparan Sulfate Proteoglycans")) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:28420982 + + complex(a(CONSO:"Tau aggregates"), a(MESH:"Heparan Sulfate Proteoglycans")) increases complex(a(CONSO:"Tau aggregates"), a(GO:"cell surface")) + + + + + + + pubmed:28420982 + + complex(a(CONSO:"Tau aggregates"), a(MESH:"Heparan Sulfate Proteoglycans")) increases bp(GO:macropinocytosis) + + + + + + + + + pubmed:28420982 + + a(MESH:"Heparan Sulfate Proteoglycans") association bp(GO:"neurofibrillary tangle assembly") + + + + + + + pubmed:28420982 + + a(MESH:"Heparan Sulfate Proteoglycans") association a(CONSO:"dense core plaques") + + + + + + + pubmed:28420982 + + a(MESH:"Heparan Sulfate Proteoglycans") association path(MESH:"Cerebral Amyloid Angiopathy, Familial") + + + + + + + pubmed:28420982 + + a(MESH:"Heparan Sulfate Proteoglycans") increases a(CONSO:"Tau fibrils") + + + + + + + pubmed:28420982 + + a(MESH:"Heparan Sulfate Proteoglycans") increases a(CONSO:"amyloid-beta fibrils") + + + + + + + pubmed:28420982 + + a(MESH:"Heparan Sulfate Proteoglycans") increases complex(a(CONSO:"Tau aggregates"), a(GO:"cell surface")) + + + + + + + pubmed:28420982 + + a(MESH:"Heparan Sulfate Proteoglycans") increases tloc(p(HGNC:MAPT), fromLoc(GO:"extracellular space"), toLoc(GO:"intracellular part")) + + + + + + + pubmed:28420982 + + a(CONSO:"dense core plaques") association a(MESH:"Heparan Sulfate Proteoglycans") + + + + + + + + + pubmed:28420982 + + a(CONSO:"Tau annular protofibrils") association path(MESH:Tauopathies) + + + + + + + pubmed:28420982 + + complex(p(HGNC:DNM1L), p(HGNC:MAPT)) increases bp(HP:Neurodegeneration) + + + + + + + pubmed:28420982 + + p(HGNC:MAPT, frag("421_?")) decreases bp(GO:"mitochondrion organization") + + + + + + + pubmed:28420982 + + complex(p(HGNC:APAF1), p(HGNC:CYCS)) increases act(p(HGNC:CASP9)) + + + + + + + pubmed:23702978 + + complex(p(HGNC:APAF1), p(HGNC:CYCS)) increases bp(GO:"apoptosome assembly") + + + + + + + pubmed:29311797 + + path(MESH:"Chronic Traumatic Encephalopathy") isA path(MESH:Tauopathies) + + + + + + + pubmed:29276758 + + path(MESH:"Chronic Traumatic Encephalopathy") positiveCorrelation p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280)) + + + + + + + pubmed:29311797 + + p(HGNC:HSP90AA1) association bp(GO:growth) + + + + + + + pubmed:29311797 + + p(HGNC:HSP90AA1) association bp(GO:"regulation of cell cycle") + + + + + + + pubmed:29311797 + + p(HGNC:HSP90AA1) association bp(MESH:Cytoprotection) + + + + + + + pubmed:29311797 + + p(HGNC:HSP90AA1) association path(MESH:"Neoplasm Metastasis") + + + + + + + pubmed:29311797 + + bp(GO:growth) association p(HGNC:HSP90AA1) + + + + + + + pubmed:29311797 + + bp(MESH:Cytoprotection) association p(HGNC:HSP90AA1) + + + + + + + pubmed:29311797 + + path(MESH:"Neoplasm Metastasis") association p(HGNC:HSP90AA1) + + + + + + + pubmed:29311797 + + bp(GO:"cell maturation") association p(HGNC:HSP90AB1) + + + + + + + pubmed:29311797 + + bp(GO:"adaptation of signaling pathway") association p(HGNC:HSP90AB1) + + + + + + + pubmed:29311797 + + p(HGNC:PPID) isA a(MESH:Immunophilins) + + + + + + + + + pubmed:29311797 + + p(HGNC:PPID) decreases a(CONSO:"Tau fibrils") + + + + + + + pubmed:29311797 + + p(HGNC:PPID) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:29311797 + + p(HGNC:PPID) increases bp(GO:memory) + + + + + + + pubmed:29311797 + + p(HGNC:PPID) decreases bp(GO:"neuron apoptotic process") + + + + + + + pubmed:29311797 + + p(HGNC:FKBPL) isA a(MESH:Immunophilins) + + + + + + + + + pubmed:29311797 + + complex(p(FPLX:HSP90), p(HGNC:AIP)) regulates bp(GO:"glucocorticoid receptor signaling pathway") + + + + + + + + + pubmed:29311797 + + complex(p(HGNC:FKBP4), p(HGNC:MAPT)) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:29311797 + + bp(GO:"glucocorticoid receptor signaling pathway") association a(CONSO:"Tau aggregates") + + + + + + + pubmed:29311797 + + p(HGNC:TOMM34) decreases path(MESH:Tauopathies) + + + + + + + pubmed:29311797 + + complex(p(FPLX:HSP90), p(HGNC:CDC37)) increases p(HGNC:GSK3B) + + + + + + + pubmed:29311797 + + complex(p(FPLX:HSP90), p(HGNC:CDC37)) increases p(HGNC:MAPK13) + + + + + + + pubmed:21367866 + + complex(p(FPLX:HSP90), p(HGNC:CDC37)) positiveCorrelation act(p(HGNC:AKT1), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:21367866 + + complex(p(FPLX:HSP90), p(HGNC:CDC37)) negativeCorrelation deg(p(HGNC:MAPT)) + + + + + + + pubmed:29311797 + + act(p(HGNC:MAPK13), ma(go:0016301 ! "kinase activity")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:11943212 + + p(HGNC:MAPK13) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 181)) + + + + + + + pubmed:11943212 + + p(HGNC:MAPK13) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 396)) + + + + + + + pubmed:11943212 + + p(HGNC:MAPK13) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + + + + + + + pubmed:11943212 + + p(HGNC:MAPK13) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) + + + + + + + pubmed:29311797 + + p(MGI:Ahsa1) increases a(CONSO:"Tau oligomers") + + + + + + + pubmed:29311797 + + p(MGI:Ahsa1) increases bp(GO:"neuron apoptotic process") + + + + + + + + + pubmed:29311797 + + p(HGNC:S100A1) increases p(HGNC:MAPT) + + + + + + + pubmed:29311797 + + p(HGNC:S100A1) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:29311797 + + complex(p(FPLX:HSP90), p(HGNC:FNIP1)) decreases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) + + + + + + + pubmed:29311797 + + complex(p(FPLX:HSP90), p(HGNC:FNIP1), p(HGNC:FNIP2)) increases p(HGNC:FLCN) + + + + + + + pubmed:29311797 + + p(FPLX:HSP90, pmod(go:0006468 ! "protein phosphorylation")) decreases act(p(FPLX:HSP90)) + + + + + + + pubmed:29311797 + + p(FPLX:HSP90, pmod(go:0006473 ! "protein acetylation")) decreases complex(a(CHEBI:ATP), p(FPLX:HSP90)) + + + + + + + pubmed:29311797 + + p(FPLX:HSP90, pmod(go:0017014 ! "protein nitrosylation")) decreases act(p(FPLX:HSP90)) + + + + + + + pubmed:29311797 + + p(FPLX:HSP90, pmod(go:0016567 ! "protein ubiquitination")) decreases act(p(FPLX:HSP90)) + + + + + + + pubmed:29311797 + + p(FPLX:HSP90, pmod(GO:"protein oxidation")) decreases act(p(FPLX:HSP90)) + + + + + + + pubmed:29311797 + + a(CONSO:EC102) increases deg(p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) + + + + + + + pubmed:29311797 + + a(PUBCHEM:14719853) decreases act(p(FPLX:HSP90), ma(GO:"ATPase activity")) + + + + + + + pubmed:29311797 + + a(PUBCHEM:14719853) decreases p(MGI:Mapt) + + + + + + + pubmed:29311797 + + a(CHEBI:"withaferin A") decreases act(p(FPLX:HSP90)) + + + + + + + pubmed:29311797 + + a(CHEBI:"withaferin A") decreases act(p(HGNC:CDC37)) + + + + + + + pubmed:29311797 + + a(CHEBI:"withaferin A") decreases p(HGNC:MAPT) + + + + + + + pubmed:27181519 + + a(CHEBI:"withaferin A") association bp(GO:autophagy) + + + + + + + pubmed:29311797 + + a(PUBCHEM:162859) decreases complex(p(FPLX:HSP90), p(HGNC:CDC37)) + + + + + + + pubmed:29311797 + + a(PUBCHEM:162859) causesNoChange act(p(FPLX:HSP90), ma(GO:"ATPase activity")) + + + + + + + pubmed:29311797 + + a(PUBCHEM:4456430) decreases path(MESH:"Alzheimer Disease") + + + + + + + pubmed:29311797 + + a(CONSO:KU-177) decreases act(p(HGNC:AHSA1)) + + + + + + + pubmed:29311797 + + a(CONSO:KU-177) decreases p(HGNC:MAPT, var("p.Pro301Leu")) + + + + + + + pubmed:26751493 + + r(MGI:Mapt) partOf a(CL:0000127) + + + + + + + pubmed:26751493 + + r(MGI:Mapt) partOf a(CL:0000128) + + + + + + + pubmed:26751493 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 68)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:26751493 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 69)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:26751493 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 71)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:26751493 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 113)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:26751493 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 123)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:26751493 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 153)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:26751493 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 175)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:26751493 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 184)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:26751493 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 185)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:26751493 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 191)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:26751493 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 197)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:23088643 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 197)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:16566606 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 197)) positiveCorrelation a(GO:microtubule) + + + + + + + pubmed:26751493 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 210)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:26751493 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 237)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:26751493 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 238)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:26751493 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 258)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:26751493 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 289)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:26751493 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 394)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 394)) association a(CONSO:"paired helical filaments") + + + + + + + pubmed:16566606 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 394)) negativeCorrelation act(p(HGNC:MAPT)) + + + + + + + pubmed:16566606 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 394)) positiveCorrelation a(GO:microtubule) + + + + + + + pubmed:26751493 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 403)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:26751493 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 409)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:26751493 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 435)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:26751493 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 427)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:26751493 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 433)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:26751493 + + p(CONSO:"microtubule-binding region") association p(HGNC:HDAC6) + + + + + + + pubmed:26751493 + + p(CONSO:"microtubule-binding region") association p(HGNC:HDAC6) + + + + + + + pubmed:26751493 + + p(CONSO:"microtubule-binding region") partOf p(HGNC:MAPT) + + + + + + + pubmed:17493042 + + p(CONSO:"microtubule-binding region") partOf p(HGNC:MAPT) + + + + + + + pubmed:17493042 + + p(CONSO:"microtubule-binding region") increases act(p(HGNC:MAPT), ma(GO:"microtubule binding")) + + + + + + + pubmed:10464280 + + p(CONSO:"microtubule-binding region") isA p(HGNC:MAPT) + + + + + + + pubmed:10537045 + + p(CONSO:"microtubule-binding region") partOf p(HGNC:MAPT) + + + + + + + pubmed:26751493 + + p(CONSO:"microtubule-binding region") partOf p(HGNC:MAPT) + + + + + + + pubmed:17493042 + + p(CONSO:"microtubule-binding region") equivalentTo p(HGNC:MAPT, frag("199_370")) + + + + + + + pubmed:21757739 + + p(CONSO:"microtubule-binding region") partOf p(CONSO:"assembly domain") + + + + + + + pubmed:21757739 + + p(CONSO:"microtubule-binding region") equivalentTo p(HGNC:MAPT, frag("244_369")) + + + + + + + pubmed:1918161 + + p(CONSO:"microtubule-binding region") equivalentTo p(HGNC:MAPT, frag("237_367")) + + + + + + + + + pubmed:10464280 + + p(CONSO:"microtubule-binding region") positiveCorrelation act(complex(GO:microtubule)) + + + + + + + pubmed:18500754 + + p(CONSO:"microtubule-binding region") association p(HGNC:HSPA8) + + + + + + + pubmed:18500754 + + p(CONSO:"microtubule-binding region") association p(INTERPRO:"Heat shock protein 70kD, C-terminal domain superfamily") + + + + + + + pubmed:8391280 + + p(CONSO:"microtubule-binding region") association p(FPLX:Ubiquitin) + + + + + + + pubmed:10537045 + + p(CONSO:"microtubule-binding region") association act(p(HGNC:TGM2)) + + + + + + + pubmed:26751493 + + p(CONSO:"tubulin-binding repeat 1") association g(CONSO:"APOE e3") + + + + + + + pubmed:26751493 + + p(CONSO:"tubulin-binding repeat 1") association g(CONSO:"APOE e3") + + + + + + + pubmed:26751493 + + p(CONSO:"tubulin-binding repeat 1") partOf p(CONSO:"microtubule-binding region") + + + + + + + pubmed:17493042 + + p(CONSO:"tubulin-binding repeat 1") partOf p(CONSO:"microtubule-binding region") + + + + + + + pubmed:26751493 + + p(CONSO:"tubulin-binding repeat 1") partOf p(CONSO:"microtubule-binding region") + + + + + + + pubmed:17493042 + + p(CONSO:"tubulin-binding repeat 1") isA p(INTERPRO:"Microtubule associated protein, tubulin-binding repeat") + + + + + + + pubmed:17493042 + + p(CONSO:"tubulin-binding repeat 1") equivalentTo p(CONSO:"Tau isoform F (441 aa)", frag("244_274")) + + + + + + + pubmed:23407988 + + p(CONSO:"tubulin-binding repeat 1") partOf p(CONSO:"4R tau") + + + + + + + pubmed:23407988 + + p(CONSO:"tubulin-binding repeat 1") partOf p(CONSO:"3R tau") + + + + + + + pubmed:26751493 + + g(CONSO:"APOE e3") association p(CONSO:"tubulin-binding repeat 1") + + + + + + + pubmed:26751493 + + g(CONSO:"APOE e3") association p(CONSO:"tubulin-binding repeat 1") + + + + + + + pubmed:26751493 + + p(CONSO:"projection domain") association p(HGNC:LCK) + + + + + + + pubmed:26751493 + + p(CONSO:"projection domain") association p(HGNC:FGR) + + + + + + + pubmed:26751493 + + p(CONSO:"projection domain") association p(HGNC:SRC) + + + + + + + pubmed:26751493 + + p(CONSO:"projection domain") association p(HGNC:GRB2) + + + + + + + pubmed:26751493 + + p(CONSO:"projection domain") association p(FPLX:PLC) + + + + + + + pubmed:26751493 + + p(CONSO:"projection domain") association a(CHEBI:phosphatidylinositol) + + + + + + + pubmed:26751493 + + p(CONSO:"projection domain") association a(CHEBI:"phosphatidylinositol bisphosphate") + + + + + + + pubmed:26751493 + + p(CONSO:"projection domain") association p(HGNC:PIN1) + + + + + + + pubmed:26751493 + + p(CONSO:"projection domain") partOf p(HGNC:MAPT) + + + + + + + pubmed:17493042 + + p(CONSO:"projection domain") partOf p(HGNC:MAPT) + + + + + + + pubmed:26751493 + + p(CONSO:"projection domain") association p(HGNC:FYN) + + + + + + + pubmed:26751493 + + p(CONSO:"projection domain") association p(HGNC:DLG4) + + + + + + + pubmed:26751493 + + p(CONSO:"projection domain") association a(MESH:"Receptors, N-Methyl-D-Aspartate") + + + + + + + pubmed:17493042 + + p(CONSO:"projection domain") equivalentTo p(INTERPRO:"MAP2/Tau projection") + + + + + + + pubmed:17493042 + + p(CONSO:"projection domain") equivalentTo p(HGNC:MAPT, frag("1_198")) + + + + + + + + + + + + + + + + + + + + + + + pubmed:26751493 + + p(CONSO:"projection domain") association p(MESH:"Receptors, N-Methyl-D-Aspartate") + + + + + + + pubmed:26751493 + + p(HGNC:FGR) association p(CONSO:"projection domain") + + + + + + + + + pubmed:26751493 + + p(HGNC:GRB2) association p(CONSO:"projection domain") + + + + + + + + + + + + + pubmed:26751493 + + a(CHEBI:"phosphatidylinositol bisphosphate") association p(CONSO:"projection domain") + + + + + + + + + pubmed:26751493 + + path(CONSO:"Argyrophilic Grain Disease") positiveCorrelation p(CONSO:"4R tau") + + + + + + + pubmed:26751493 + + p(HGNC:MAPT, var("p.Val337Met")) positiveCorrelation path(MESH:"Frontotemporal Dementia") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, var("p.Val337Met")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, var("p.Val337Met")) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:26751493 + + p(HGNC:MAPT, var("p.Gly272Val")) positiveCorrelation path(MESH:"Frontotemporal Dementia") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, var("p.Gly272Val")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, var("p.Gly272Val")) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, var("p.Gly272Val")) decreases p(CONSO:"4R tau") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, var("p.Gly272Val")) increases p(CONSO:"3R tau") + + + + + + + pubmed:26751493 + + p(HGNC:MAPT, var("p.Arg406Trp")) positiveCorrelation path(MESH:"Frontotemporal Dementia") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, var("p.Arg406Trp")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, var("p.Arg406Trp")) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:26751493 + + p(HGNC:PSEN1, var("p.Gly183Val")) positiveCorrelation path(MESH:"Frontotemporal Dementia") + + + + + + + pubmed:26751493 + + p(HGNC:PSEN1, var("p.Gly183Val")) positiveCorrelation path(MESH:"Niemann-Pick Diseases") + + + + + + + pubmed:26751493 + + p(HGNC:PSEN1, var("p.Gly183Val")) causesNoChange a(CHEBI:amyloid-beta) + + + + + + + pubmed:26751493 + + g(DBSNP:rs2471738) association path(MESH:"Parkinson Disease") + + + + + + + pubmed:26751493 + + g(DBSNP:rs242557) association path(MESH:"Parkinson Disease") + + + + + + + pubmed:26751493 + + p(HGNC:MAPT, var("p.Glu391*")) association p(CONSO:"paired helical filaments") + + + + + + + pubmed:25974414 + + p(HGNC:MAPT, var("p.Glu391*")) partOf a(GO:"neurofibrillary tangle") + + + + + + + pubmed:25974414 + + p(HGNC:MAPT, var("p.Glu391*")) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:25974414 + + p(HGNC:MAPT, var("p.Glu391*")) isA p(HGNC:MAPT) + + + + + + + pubmed:22002427 + + p(HGNC:MAPT, var("p.Glu391*")) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) + + + + + + + pubmed:22002427 + + p(HGNC:MAPT, var("p.Glu391*")) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 205)) + + + + + + + pubmed:26751493 + + p(HGNC:SNAP25) negativeCorrelation a(GO:"neurofibrillary tangle") + + + + + + + + + pubmed:26751493 + + p(PFAM:Syntaxin) negativeCorrelation a(GO:"neurofibrillary tangle") + + + + + + + pubmed:26751493 + + complex(a(CHEBI:heparin), p(CONSO:"Tau aggregates")) positiveCorrelation bp(GO:macropinocytosis) + + + + + + + pubmed:26751493 + + complex(a(CHEBI:heparin), p(CONSO:"Tau aggregates")) association bp(GO:macropinocytosis) + + + + + + + pubmed:26751493 + + bp(GO:"cell-cell signaling via exosome") isA tloc(a(CONSO:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) + + + + + + + pubmed:26751493 + + a(CL:0000129) increases tloc(a(CONSO:"Tau aggregates"), fromLoc(MESH:Neurons), toLoc(MESH:Neurons)) + + + + + + + pubmed:26751493 + + a(CHEBI:"trans-5-O-caffeoyl-D-quinic acid") decreases act(p(HGNC:PPME1)) + + + + + + + pubmed:26751493 + + a(CHEBI:"trans-5-O-caffeoyl-D-quinic acid") increases bp(GO:cognition) + + + + + + + pubmed:26751493 + + a(CHEBI:"trans-5-O-caffeoyl-D-quinic acid") increases bp(GO:"motor behavior") + + + + + + + pubmed:26751493 + + a(CHEBI:"trans-5-O-caffeoyl-D-quinic acid") decreases act(p(MGI:Ppme1)) + + + + + + + pubmed:26751493 + + p(CONSO:"Tau antibody, RG7345") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) + + + + + + + pubmed:26751493 + + a(CHEBI:"azure A") increases bp(GO:"protein catabolic process") + + + + + + + pubmed:26751493 + + a(CHEBI:"azure A") association bp(GO:"response to oxidative stress") + + + + + + + pubmed:26751493 + + a(CHEBI:"azure A") decreases act(p(HGNC:CASP1)) + + + + + + + pubmed:26751493 + + a(CHEBI:"azure A") decreases act(p(HGNC:CASP3)) + + + + + + + pubmed:26751493 + + a(CHEBI:"azure B") increases bp(GO:"protein catabolic process") + + + + + + + pubmed:26751493 + + a(CHEBI:"azure B") association bp(GO:"response to oxidative stress") + + + + + + + pubmed:26751493 + + a(CHEBI:"azure B") decreases act(p(HGNC:CASP1)) + + + + + + + pubmed:26751493 + + a(CHEBI:"azure B") decreases act(p(HGNC:CASP3)) + + + + + + + pubmed:26751493 + + a(CONSO:thiohydantoin) decreases p(CONSO:"Tau aggregates") + + + + + + + pubmed:26751493 + + a(CONSO:oxazolidinedione) decreases p(CONSO:"Tau aggregates") + + + + + + + pubmed:26751493 + + a(CONSO:thioxooxazolidine) decreases p(CONSO:"Tau aggregates") + + + + + + + pubmed:26751493 + + a(CHEBI:thiostrepton) decreases p(CONSO:"Tau aggregates") + + + + + + + pubmed:26751493 + + a(CONSO:sudoxicam) decreases p(CONSO:"Tau aggregates") + + + + + + + pubmed:26751493 + + a(CHEBI:isoniazide) decreases p(CONSO:"Tau aggregates") + + + + + + + pubmed:26751493 + + a(CHEBI:Iproniazid) decreases p(CONSO:"Tau aggregates") + + + + + + + pubmed:26751493 + + a(CHEBI:iproclozide) decreases p(CONSO:"Tau aggregates") + + + + + + + pubmed:26751493 + + a(CONSO:isocarboxazide) decreases p(CONSO:"Tau aggregates") + + + + + + + pubmed:26751493 + + a(CHEBI:myricetin) decreases p(CONSO:"Tau aggregates") + + + + + + + pubmed:26751493 + + a(CHEBI:emodin) decreases p(CONSO:"Tau aggregates") + + + + + + + pubmed:26751493 + + a(CHEBI:daunorubicin) decreases p(CONSO:"Tau aggregates") + + + + + + + pubmed:26751493 + + a(CHEBI:quinalizarin) decreases p(CONSO:"Tau aggregates") + + + + + + + pubmed:26458742 + + p(CONSO:"Tau isoform D (383 aa)", pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) positiveCorrelation p(CONSO:"Tau isoform D (383 aa)", var("p.Pro301Leu")) + + + + + + + pubmed:26458742 + + p(CONSO:"Tau isoform D (383 aa)", pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) positiveCorrelation p(CONSO:"Tau isoform D (383 aa)", var("p.Pro301Leu")) + + + + + + + pubmed:26458742 + + p(CONSO:"Tau isoform D (383 aa)", pmod(go:0006468 ! "protein phosphorylation", Ser, 400)) positiveCorrelation p(CONSO:"Tau isoform D (383 aa)", var("p.Pro301Leu")) + + + + + + + pubmed:26458742 + + p(CONSO:"Tau isoform D (383 aa)", pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) positiveCorrelation p(CONSO:"Tau isoform D (383 aa)", var("p.Pro301Leu")) + + + + + + + pubmed:26458742 + + p(CONSO:"Tau isoform D (383 aa)", pmod(go:0006468 ! "protein phosphorylation", Ser, 409)) positiveCorrelation p(CONSO:"Tau isoform D (383 aa)", var("p.Pro301Leu")) + + + + + + + pubmed:26458742 + + p(CONSO:"Tau isoform D (383 aa)", pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) positiveCorrelation p(CONSO:"Tau isoform D (383 aa)", var("p.Pro301Leu")) + + + + + + + pubmed:26195256 + + p(HGNC:CLU, var("?")) association path(MESH:"Alzheimer Disease") + + + + + + + pubmed:26195256 + + path(MESH:"Craniocerebral Trauma") increases path(MESH:"Alzheimer Disease") + + + + + + + pubmed:26195256 + + bp(MESH:Exercise) decreases path(MESH:"Alzheimer Disease") + + + + + + + pubmed:26195256 + + a(MESH:"Cerebral Ventricles") positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:26195256 + + path(MESH:"Cerebral Amyloid Angiopathy") association a(CONSO:"amyloid-beta aggregates") + + + + + + + pubmed:26195256 + + p(MESH:Endopeptidases) increases bp(GO:"protein catabolic process") + + + + + + + pubmed:26195256 + + p(MESH:Endopeptidases) increases deg(a(CHEBI:amyloid-beta, loc(GO:intracellular))) + + + + + + + pubmed:26195256 + + act(complex(a(MESH:Endosomes), a(MESH:Lysosomes))) increases bp(GO:"protein catabolic process") + + + + + + + + + + + + + + + pubmed:26195256 + + act(p(MESH:Cathepsins)) increases deg(a(CHEBI:amyloid-beta, loc(GO:intracellular))) + + + + + + + pubmed:26195256 + + p(HGNC:MMP3) increases deg(a(CHEBI:amyloid-beta, loc(GO:"extracellular region"))) + + + + + + + pubmed:29626319 + + act(p(HGNC:MMP3)) increases deg(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:26195256 + + p(HGNC:FOLH1) increases deg(a(CHEBI:amyloid-beta, loc(GO:"extracellular region"))) + + + + + + + pubmed:26195256 + + p(HGNC:ECE1) increases deg(a(CHEBI:amyloid-beta, loc(GO:"extracellular region"))) + + + + + + + pubmed:29626319 + + p(HGNC:ECE1) increases deg(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:26195256 + + p(HGNC:ECE2) increases deg(a(CHEBI:amyloid-beta, loc(GO:"extracellular region"))) + + + + + + + pubmed:26195256 + + p(HGNC:PLAT) increases deg(a(CHEBI:amyloid-beta, loc(GO:"extracellular region"))) + + + + + + + pubmed:26195256 + + p(HGNC:ACE) increases deg(a(CHEBI:amyloid-beta, loc(GO:"extracellular region"))) + + + + + + + pubmed:29626319 + + p(HGNC:ACE) increases deg(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:29626319 + + p(HGNC:ACE) increases deg(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:29626319 + + p(HGNC:ACE) increases rxn(reactants(a(CHEBI:"Angiotensin I")), products(a(CHEBI:"angiotensin II"))) + + + + + + + pubmed:29626319 + + p(HGNC:ACE) regulates a(MESH:"Body Fluids") + + + + + + + pubmed:29626319 + + p(HGNC:ACE) regulates bp(MESH:"Blood Pressure") + + + + + + + pubmed:29626319 + + p(HGNC:ACE) regulates bp(GO:"sodium ion transmembrane transport") + + + + + + + pubmed:29626319 + + act(p(HGNC:ACE)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:26195256 + + a(MESH:"Muscle, Smooth, Vascular") increases deg(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:26195256 + + p(MESH:Neprilysin) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:26195256 + + p(HGNC:LRP2) decreases a(CHEBI:amyloid-beta) + + + + + + + pubmed:26195256 + + p(MESH:"ATP-Binding Cassette Transporters") increases tloc(a(CHEBI:amyloid-beta), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:Brain)) + + + + + + + pubmed:26195256 + + act(p(HGNC:PPIA)) decreases bp(GO:"establishment of blood-brain barrier") + + + + + + + pubmed:26195256 + + path(MESH:Sleep) increases act(a(MESH:"Blood-Brain Barrier")) + + + + + + + pubmed:26195256 + + path(MESH:Sleep) decreases a(CHEBI:amyloid-beta) + + + + + + + pubmed:29626319 + + path(MESH:Sleep) decreases a(CHEBI:amyloid-beta) + + + + + + + pubmed:26195256 + + path(MESH:Sleep) increases p(HGNC:LRP1) + + + + + + + pubmed:26195256 + + a(MESH:"Cerebrospinal Fluid") negativeCorrelation path(MESH:Aging) + + + + + + + pubmed:26195256 + + a(MESH:"Cerebrospinal Fluid") negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:26195256 + + act(p(HGNC:AQP1)) negativeCorrelation path(MESH:Aging) + + + + + + + pubmed:26195256 + + act(p(HGNC:AQP1)) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:26195256 + + act(p(HGNC:AQP1)) increases a(MESH:"Cerebrospinal Fluid") + + + + + + + pubmed:26195256 + + act(p(HGNC:AQP1)) increases tloc(a(CHEBI:water), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:29626319 + + p(HGNC:AQP1) increases act(a(MESH:"Choroid Plexus")) + + + + + + + pubmed:29626319 + + p(HGNC:AQP1) decreases a(CHEBI:amyloid-beta) + + + + + + + pubmed:26195256 + + path(MESH:"Calcification, Physiologic") decreases a(MESH:"Cerebrospinal Fluid") + + + + + + + pubmed:26195256 + + act(p(MESH:Calpain)) increases deg(p(HGNC:MAPT)) + + + + + + + pubmed:27373205 + + p(HGNC:MAPT, var("p.Ser422Glu")) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:27373205 + + p(HGNC:MAPT, var("p.Ser422Glu")) increases a(CONSO:"Tau oligomers") + + + + + + + + + pubmed:27373205 + + p(HGNC:MAPT, var("p.Ser422Glu")) decreases bp(GO:"anterograde axonal protein transport") + + + + + + + pubmed:27373205 + + p(HGNC:MAPT, var("p.Ser422Glu")) causesNoChange bp(GO:"retrograde axonal protein transport") + + + + + + + pubmed:27373205 + + composite(a(CONSO:"Tau aggregates"), p(HGNC:MAPT, var("p.Ser422Glu"))) increases a(CONSO:"Tau oligomers") + + + + + + + pubmed:27373205 + + composite(a(CONSO:"Tau aggregates"), p(HGNC:MAPT, var("p.Ser422Glu"))) increases a(CONSO:"Tau dimers") + + + + + + + pubmed:27373205 + + composite(a(CONSO:"Tau aggregates"), p(HGNC:MAPT, var("p.Ser422Glu"))) decreases bp(GO:"anterograde axonal protein transport") + + + + + + + pubmed:27373205 + + composite(a(CONSO:"Tau aggregates"), p(HGNC:MAPT, var("p.Ser422Glu"))) decreases bp(GO:"retrograde axonal protein transport") + + + + + + + pubmed:27373205 + + composite(a(CONSO:"Tau aggregates"), p(HGNC:MAPT)) increases a(CONSO:"Tau oligomers") + + + + + + + pubmed:27373205 + + composite(a(CONSO:"Tau aggregates"), p(HGNC:MAPT)) increases a(CONSO:"Tau dimers") + + + + + + + pubmed:26631930 + + m(HGNC:MIR132) negativeCorrelation path(MESH:"Supranuclear Palsy, Progressive") + + + + + + + pubmed:26631930 + + m(HGNC:MIR132) decreases p(CONSO:"4R tau") + + + + + + + pubmed:26631930 + + complex(r(HGNC:MAPT), r(HGNC:MIR219A1)) decreases p(HGNC:MAPT) + + + + + + + + + pubmed:26631930 + + complex(GO:"ribonucleoprotein granule") increases p(HGNC:MAPT) + + + + + + + pubmed:27181519 + + complex(GO:"ribonucleoprotein granule") association bp(GO:"RNA processing") + + + + + + + pubmed:27181519 + + complex(GO:"ribonucleoprotein granule") regulates a(MESH:"RNA, Messenger") + + + + + + + pubmed:26631930 + + p(HGNC:HM13) increases complex(GO:"ribonucleoprotein granule") + + + + + + + pubmed:26631930 + + a(PUBCHEM:39484) decreases act(complex(GO:"mitochondrial respiratory chain complex I")) + + + + + + + pubmed:26631930 + + p(HGNC:SRSF2) increases p(CONSO:"4R tau") + + + + + + + pubmed:29226865 + + act(p(HGNC:SRSF2)) increases p(CONSO:"4R tau") + + + + + + + pubmed:26631930 + + p(HGNC:SRSF2) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") + + + + + + + + + pubmed:29226865 + + act(p(HGNC:SRSF2)) positiveCorrelation p(HGNC:SRSF2, pmod(go:0006473 ! "protein acetylation", Lys, 52)) + + + + + + + pubmed:26631930 + + complex(a(MESH:RNA), p(HGNC:MAPT)) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:26631930 + + complex(a(MESH:RNA), p(HGNC:MAPT)) increases path(CONSO:Neurodegeneration) + + + + + + + + + pubmed:24561250 + + a(MESH:RNA) increases act(complex(GO:"inflammasome complex")) + + + + + + + pubmed:26631930 + + complex(a(GO:microtubule), p(CONSO:"4R tau")) increases bp(GO:"microtubule polymerization") + + + + + + + pubmed:26631930 + + complex(a(GO:microtubule), p(CONSO:"3R tau")) increases bp(GO:"microtubule polymerization") + + + + + + + pubmed:26631930 + + p(HGNC:PPM1A) directlyDecreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 214), pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + + + + + + + + + pubmed:29238289 + + rxn(reactants(p(HGNC:MAPT)), products(p(HGNC:MAPT, frag("1_421")), p(HGNC:MAPT, frag("421_*")))) increases tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + + + + + pubmed:26631930 + + complex(p(HGNC:MAPK8IP1), p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) decreases complex(GO:"kinesin complex") + + + + + + + pubmed:26631930 + + complex(p(HGNC:MAPK8IP1), p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation))) decreases complex(GO:"kinesin complex") + + + + + + + pubmed:26631930 + + complex(GO:"kinesin complex") regulates bp(GO:"axonal transport") + + + + + + + pubmed:19491104 + + act(complex(GO:"kinesin complex")) positiveCorrelation act(p(HGNC:MAPK8IP1)) + + + + + + + pubmed:19491104 + + act(complex(GO:"kinesin complex")) positiveCorrelation act(p(HGNC:KLC1)) + + + + + + + pubmed:19491104 + + act(complex(GO:"kinesin complex")) positiveCorrelation bp(GO:"vesicle-mediated transport") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 163)) decreases deg(p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 163))) + + + + + + + pubmed:26192747 + + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 163)) isA p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 369)) decreases deg(p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 369))) + + + + + + + pubmed:26192747 + + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 369)) isA p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) + + + + + + + pubmed:26192747 + + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 369)) partOf p(CONSO:"microtubule-binding region") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, pmod(go:0006487 ! "protein N-linked glycosylation")) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, pmod(go:0006487 ! "protein N-linked glycosylation")) increases a(CONSO:"paired helical filaments") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, pmod(go:0006487 ! "protein N-linked glycosylation")) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, pmod(go:0006487 ! "protein N-linked glycosylation")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, pmod(go:0006493 ! "protein O-linked glycosylation")) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, pmod(go:0006493 ! "protein O-linked glycosylation")) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, pmod(go:0006493 ! "protein O-linked glycosylation")) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, pmod(go:0006493 ! "protein O-linked glycosylation")) decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, pmod(CONSO:glycation)) association a(CONSO:"paired helical filaments") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, pmod(CONSO:glycation)) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, pmod(CONSO:glycation)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + + + + + + + pubmed:19517062 + + p(HGNC:MAPT, pmod(CONSO:glycation)) increases a(CHEBI:"advanced glycation end-product") + + + + + + + pubmed:19517062 + + p(HGNC:MAPT, pmod(CONSO:glycation)) partOf p(CONSO:"Tau aggregates") + + + + + + + pubmed:19517062 + + p(HGNC:MAPT, pmod(CONSO:glycation)) increases a(CONSO:"Tau oligomers") + + + + + + + + + pubmed:19517062 + + p(HGNC:MAPT, pmod(CONSO:glycation)) increases complex(a(CHEBI:"advanced glycation end-product"), p(HGNC:MAPT, pmod(CONSO:glycation))) + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, pmod(GO:"protein peptidyl-prolyl isomerization")) association a(CONSO:"paired helical filaments") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, pmod(GO:"protein peptidyl-prolyl isomerization")) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 18)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 18)) positiveCorrelation path(MESH:Tauopathies) + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 18)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 18)) regulates a(CONSO:"Tau aggregates") + + + + + + + pubmed:16566606 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 18)) decreases bp(GO:"tubulin complex assembly") + + + + + + + pubmed:16566606 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 18)) association p(HGNC:MAPT, pmod(CONSO:misfolded)) + + + + + + + pubmed:22057784 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 18)) positiveCorrelation path(MESH:"Pick Disease of the Brain") + + + + + + + pubmed:18562203 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 18)) association act(a(MESH:Astrocytes)) + + + + + + + pubmed:18562203 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 18)) positiveCorrelation path(MESH:"Plaque, Amyloid") + + + + + + + pubmed:17050703 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 18)) isA p(HGNC:MAPT, pmod(CONSO:nitration)) + + + + + + + pubmed:16566606 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 18)) decreases bp(GO:"microtubule polymerization") + + + + + + + pubmed:16566606 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 18)) positiveCorrelation a(CONSO:"paired helical filaments") + + + + + + + pubmed:16566606 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 18)) negativeCorrelation act(p(HGNC:MAPT)) + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:17050703 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) positiveCorrelation path(MESH:Tauopathies) + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) regulates a(CONSO:"Tau aggregates") + + + + + + + pubmed:16566606 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) decreases bp(GO:"tubulin complex assembly") + + + + + + + pubmed:16566606 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) association p(HGNC:MAPT, pmod(CONSO:misfolded)) + + + + + + + pubmed:22057784 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) positiveCorrelation path(MESH:"Pick Disease of the Brain") + + + + + + + pubmed:17050703 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) association a(CONSO:"paired helical filaments") + + + + + + + pubmed:16566606 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) positiveCorrelation a(CONSO:"paired helical filaments") + + + + + + + pubmed:17050703 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) positiveCorrelation bp(GO:"neurofibrillary tangle assembly") + + + + + + + pubmed:17050703 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) partOf a(GO:"neurofibrillary tangle") + + + + + + + pubmed:17050703 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) partOf path(MESH:"Plaque, Amyloid") + + + + + + + pubmed:17050703 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) partOf a(MESH:"Neuropil Threads") + + + + + + + pubmed:17050703 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) association path(CONSO:"Corticobasal Degeneration") + + + + + + + pubmed:17050703 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) association path(MESH:"Supranuclear Palsy, Progressive") + + + + + + + pubmed:17050703 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) isA p(HGNC:MAPT, pmod(CONSO:nitration)) + + + + + + + pubmed:16566606 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) decreases bp(GO:"microtubule polymerization") + + + + + + + pubmed:16566606 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 29)) negativeCorrelation act(p(HGNC:MAPT)) + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 394)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 394)) positiveCorrelation path(MESH:Tauopathies) + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 394)) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 394)) regulates a(CONSO:"Tau aggregates") + + + + + + + pubmed:16566606 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 394)) decreases bp(GO:"tubulin complex assembly") + + + + + + + pubmed:16566606 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 394)) association p(HGNC:MAPT, pmod(CONSO:misfolded)) + + + + + + + pubmed:16566606 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 394)) decreases bp(GO:"microtubule polymerization") + + + + + + + pubmed:16566606 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 394)) positiveCorrelation a(CONSO:"paired helical filaments") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys)) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:24869773 + + p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys)) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation")) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, frag("26_230")) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, frag("124_441")) directlyIncreases complex(a(GO:microtubule), p(HGNC:MAPT, frag("124_441"))) + + + + + + + pubmed:26631930 + + complex(p(HGNC:DCTN1), p(HGNC:MAPT)) increases complex(a(GO:microtubule), p(HGNC:DCTN1)) + + + + + + + pubmed:8391280 + + complex(p(HGNC:DCTN1), p(HGNC:MAPT)) isA p(INTERPRO:"Dynein associated protein") + + + + + + + pubmed:8391280 + + complex(p(HGNC:DCTN1), p(HGNC:MAPT)) negativeCorrelation g(DBSNP:rs63750424) + + + + + + + pubmed:26631930 + + complex(a(GO:microtubule), p(HGNC:DCTN1)) increases complex(a(GO:microtubule), a(MESH:Dyneins)) + + + + + + + pubmed:26631930 + + complex(p(HGNC:APP), p(HGNC:SLC40A1)) increases tloc(a(CHEBI:"iron(0)"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + + + pubmed:26631930 + + complex(a(MESH:Actins), p(HGNC:MAPT)) increases a(GO:"actin filament bundle") + + + + + + + pubmed:26631930 + + complex(a(MESH:Actins), p(HGNC:MAPT)) regulates a(GO:"actin cytoskeleton") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, var("p.Asn279Lys")) decreases complex(a(GO:microtubule), p(HGNC:MAPT)) + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, var("p.Asn279Lys")) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, var("p.Arg5His")) decreases complex(p(HGNC:DCTN1), p(HGNC:MAPT)) + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, var("p.Arg5His")) decreases bp(GO:"axonal transport") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, var("p.Arg5His")) decreases act(p(HGNC:MAPT)) + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, var("p.Arg5Leu")) decreases complex(p(HGNC:DCTN1), p(HGNC:MAPT)) + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, var("p.Arg5Leu")) decreases bp(GO:"axonal transport") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, var("p.Leu266Val")) decreases p(CONSO:"4R tau") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, var("p.Leu266Val")) increases p(CONSO:"3R tau") + + + + + + + pubmed:26631930 + + p(CONSO:"VQIINK motif") increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:26631930 + + p(CONSO:"VQIINK motif") increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:17493042 + + p(CONSO:"VQIINK motif") partOf p(CONSO:"tubulin-binding repeat 2") + + + + + + + pubmed:17493042 + + p(CONSO:"VQIINK motif") increases p(CONSO:"paired helical filaments") + + + + + + + pubmed:17493042 + + p(CONSO:"VQIINK motif") increases bp(GO:"neurofibrillary tangle assembly") + + + + + + + pubmed:28002468 + + p(CONSO:"VQIINK motif") equivalentTo p(HGNC:MAP4, frag("992_999")) + + + + + + + pubmed:28002468 + + p(CONSO:"VQIINK motif") equivalentTo p(HGNC:MAP4, frag("1023_1030")) + + + + + + + pubmed:11606569 + + p(CONSO:"VQIINK motif") positiveCorrelation p(HGNC:MAPT, var("p.Lys280del")) + + + + + + + pubmed:11606569 + + p(CONSO:"VQIINK motif") positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) + + + + + + + pubmed:11606569 + + p(CONSO:"VQIINK motif") increases p(CONSO:"Tau aggregates") + + + + + + + pubmed:26631930 + + a(CHEBI:"polyanionic polymer") increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:26631930 + + a(CHEBI:"polyanionic polymer") increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:26631930 + + p(HGNC:YWHAZ) increases a(CONSO:"Tau aggregates") + + + + + + + + + pubmed:12551948 + + p(HGNC:YWHAZ) isA complex(p(HGNC:GSK3B), p(HGNC:MAPT), p(HGNC:YWHAZ)) + + + + + + + pubmed:12551948 + + p(HGNC:YWHAZ) association p(HGNC:MAPT) + + + + + + + pubmed:12551948 + + p(HGNC:YWHAZ) association p(HGNC:GSK3B) + + + + + + + pubmed:12551948 + + p(HGNC:YWHAZ) increases act(p(HGNC:GSK3B)) + + + + + + + pubmed:22941973 + + act(p(HGNC:YWHAZ)) increases p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) + + + + + + + pubmed:22941973 + + act(p(HGNC:YWHAZ)) decreases complex(a(MESH:Microtubules), p(RGD:Mapt)) + + + + + + + pubmed:22941973 + + act(p(HGNC:YWHAZ)) decreases bp(GO:"microtubule polymerization") + + + + + + + pubmed:22941973 + + act(p(HGNC:YWHAZ)) increases deg(p(RGD:Syp)) + + + + + + + pubmed:22941973 + + act(p(HGNC:YWHAZ)) increases act(p(FPLX:Proteasome)) + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, frag("151_391")) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, frag("1_368")) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, frag("1_368")) increases path(CONSO:Neurodegeneration) + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, frag("1_368")) decreases bp(GO:"microtubule polymerization") + + + + + + + pubmed:26631930 + + p(HGNC:F2) increases p(HGNC:MAPT, frag("258_360")) + + + + + + + pubmed:26631930 + + p(HGNC:MAPT, frag("258_360")) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:26631930 + + p(HGNC:CTSL) increases p(HGNC:MAPT, frag("258_360")) + + + + + + + pubmed:26631930 + + bp(GO:"iron ion transport") association p(HGNC:MAPT) + + + + + + + pubmed:26631930 + + bp(GO:"DNA protection") association p(HGNC:MAPT) + + + + + + + pubmed:26631930 + + tloc(p(HGNC:TTLL6), fromLoc(GO:axon), toLoc(MESH:"Dendritic Spines")) increases act(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:26631930 + + p(HGNC:SPAST) increases bp(GO:"microtubule severing") + + + + + + + pubmed:26631930 + + p(HGNC:GRIN2B, pmod(go:0006468 ! "protein phosphorylation")) increases complex(p(HGNC:DLG4), p(HGNC:GRIN2B)) + + + + + + + pubmed:26631930 + + complex(p(HGNC:DLG4), p(HGNC:GRIN2B)) increases act(a(GO:"glutamatergic synapse")) + + + + + + + pubmed:26631930 + + complex(p(HGNC:DLG4), p(HGNC:GRIN2B)) increases act(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:22817713 + + complex(a(CONSO:"Tau oligomers"), p(HGNC:HSPA1A)) decreases bp(GO:"anterograde axonal protein transport") + + + + + + + pubmed:22817713 + + complex(a(CONSO:"Tau oligomers"), p(HGNC:HSPA1A)) increases bp(GO:"anterograde axonal protein transport") + + + + + + + pubmed:22817713 + + bp(GO:"regulation of microtubule cytoskeleton organization") association p(HGNC:MAPT) + + + + + + + pubmed:22817713 + + a(CHEBI:"arachidonic acid") increases a(CONSO:"Tau oligomers") + + + + + + + pubmed:22817713 + + a(CHEBI:"arachidonic acid") increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:22817713 + + p(HGNC:PPP1CA) decreases bp(GO:"anterograde axonal protein transport") + + + + + + + pubmed:29334120 + + p(HGNC:PPP1CA) directlyDecreases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation", Ser, 397)) + + + + + + + pubmed:29334120 + + p(HGNC:PPP1CA) directlyDecreases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation", Ser, 403)) + + + + + + + pubmed:29334120 + + p(HGNC:PPP1CA) directlyDecreases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + + + + + + + pubmed:29334120 + + p(HGNC:PPP1CA) directlyDecreases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation", Ser, 409)) + + + + + + + pubmed:29334120 + + p(HGNC:PPP1CA) directlyDecreases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation", Ser, 410)) + + + + + + + pubmed:26142647 + + act(p(HGNC:PPP1CA)) directlyDecreases p(HGNC:EIF2S1, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:25001178 + + p(HGNC:PPP1CA) directlyDecreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:25001178 + + p(HGNC:PPP1CA) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:22817713 + + p(HGNC:MAPT, frag("2_18")) decreases bp(GO:"anterograde axonal protein transport") + + + + + + + + + pubmed:26671985 + + p(HGNC:MAPT, frag("2_18")) equivalentTo p(CONSO:"phosphatase-activating domain") + + + + + + + pubmed:26671985 + + p(HGNC:MAPT, frag("2_18")) partOf p(HGNC:MAPT, frag("1_151")) + + + + + + + pubmed:22817713 + + composite(p(HGNC:HSPA1A), p(HGNC:MAPT, frag("2_18"))) decreases bp(GO:"anterograde axonal protein transport") + + + + + + + pubmed:29626319 + + p(FPLX:UBE2) increases deg(a(MESH:Proteins)) + + + + + + + pubmed:29626319 + + p(HGNC:PSMD7) increases deg(a(MESH:Proteins)) + + + + + + + pubmed:29626319 + + a(MESH:"Ubiquitin-Protein Ligases") increases deg(a(MESH:Proteins)) + + + + + + + pubmed:29626319 + + a(MESH:"Tight Junctions") decreases tloc(a(MESH:Proteins), fromLoc(MESH:Brain), toLoc(MESH:Blood)) + + + + + + + pubmed:29626319 + + a(HP:"glymphatic system") decreases a(CHEBI:amyloid-beta) + + + + + + + pubmed:29626319 + + a(HP:"glymphatic system") decreases p(HGNC:MAPT) + + + + + + + pubmed:29626319 + + p(HGNC:UBB, var("?")) decreases act(p(HGNC:PSMD7)) + + + + + + + pubmed:29626319 + + p(HGNC:UBB, var("?")) decreases deg(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:29626319 + + p(FPLX:MMP) increases deg(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:29626319 + + p(HGNC:SERPINF2) increases deg(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:29626319 + + p(HGNC:SERPINF2) increases deg(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:29626319 + + p(HGNC:SERPINF2) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:29626319 + + act(p(HGNC:SERPINF2)) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + + + + + pubmed:29626319 + + a(MESH:"Receptors, Scavenger") increases deg(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:29626319 + + p(HGNC:CMKLR1) increases deg(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:29626319 + + p(FPLX:TLR) increases deg(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:23702978 + + act(p(FPLX:TLR)) increases p(HGNC:NLRP3) + + + + + + + pubmed:23702978 + + act(p(FPLX:TLR)) increases p(HGNC:IL1B) + + + + + + + pubmed:29626319 + + p(HGNC:FPR2) increases deg(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:29626319 + + a(HP:"blood-cerebrospinal fluid barrier") decreases a(CHEBI:amyloid-beta) + + + + + + + pubmed:29626319 + + complex(a(CHEBI:amyloid-beta), p(HGNC:TTR)) increases deg(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:29626319 + + a(MESH:"Lymph Nodes") decreases a(CHEBI:amyloid-beta) + + + + + + + pubmed:29626319 + + complex(a(MESH:Erythrocytes), p(HGNC:CR1)) increases deg(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:29626319 + + composite(a(CHEBI:amyloid-beta), a(MESH:"Serum Albumin")) decreases a(CHEBI:amyloid-beta) + + + + + + + + + pubmed:29626319 + + a(MESH:Aminopeptidases) increases deg(p(HGNC:MAPT)) + + + + + + + pubmed:29626319 + + a(MESH:Thrombin) increases deg(p(HGNC:MAPT)) + + + + + + + pubmed:29626319 + + a(MESH:tenuigenin) decreases a(CHEBI:"amyloid-beta polypeptide 40") + + + + + + + pubmed:29626319 + + a(MESH:tenuigenin) increases p(HGNC:PSMD7) + + + + + + + pubmed:29626319 + + bp(GO:"cAMP-mediated signaling") increases p(HGNC:PSMD7) + + + + + + + pubmed:29626319 + + a(CHEBI:wogonin) increases bp(GO:autophagy) + + + + + + + pubmed:29626319 + + a(CHEBI:wogonin) decreases a(CHEBI:amyloid-beta) + + + + + + + pubmed:29626319 + + a(CHEBI:wogonin) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:29626319 + + p(HGNC:NPAS4) increases bp(GO:autophagy) + + + + + + + pubmed:29626319 + + p(HGNC:NPAS4) increases deg(p(HGNC:MAPT)) + + + + + + + pubmed:29626319 + + p(HGNC:NPAS4) increases deg(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) + + + + + + + pubmed:29626319 + + a(CHEBI:statin) increases tloc(p(HGNC:IDE), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:29626319 + + a(CHEBI:statin) increases deg(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:29626319 + + a(CHEBI:"omega-3 fatty acid") increases deg(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:29626319 + + a(CHEBI:"all-cis-5,8,11,14,17-icosapentaenoic acid") increases act(p(HGNC:IDE)) + + + + + + + pubmed:29626319 + + a(CHEBI:"docosahexaenoic acid") increases act(p(HGNC:IDE)) + + + + + + + pubmed:29626319 + + a(CHEBI:"docosahexaenoic acid") increases deg(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:29626319 + + a(CHEBI:"docosahexaenoic acid") increases act(a(MESH:Erythrocytes)) + + + + + + + pubmed:29626319 + + a(CHEBI:atorvastatin) increases deg(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:29626319 + + a(CHEBI:atorvastatin) increases bp(GO:"ERK1 and ERK2 cascade") + + + + + + + pubmed:29626319 + + a(CHEBI:atorvastatin) increases tloc(p(HGNC:MME), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:29626319 + + a(CHEBI:nobiletin) increases act(p(HGNC:MME)) + + + + + + + pubmed:29626319 + + a(CHEBI:nobiletin) increases deg(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:29626319 + + a(CHEBI:"ginsenoside Rg1") increases act(p(HGNC:MME)) + + + + + + + pubmed:29626319 + + a(CHEBI:"ginsenoside Rg1") decreases path(MESH:Tauopathies) + + + + + + + pubmed:29626319 + + a(MESH:"Granulocyte Colony-Stimulating Factor") increases act(p(HGNC:MME)) + + + + + + + pubmed:29626319 + + a(MESH:"Granulocyte Colony-Stimulating Factor") decreases path(MESH:Tauopathies) + + + + + + + pubmed:29626319 + + p(HGNC:ANXA1) increases deg(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:29626319 + + p(HGNC:ANXA1) increases act(p(HGNC:MME)) + + + + + + + pubmed:29626319 + + complex(a(MESH:"Chemokine CX3CL1"), p(HGNC:CX3CR1)) increases deg(a(CHEBI:amyloid-beta)) + + + + + + + + + pubmed:29626319 + + p(HGNC:CD36) increases deg(a(CHEBI:amyloid-beta)) + + + + + + + + + pubmed:29626319 + + a(CHEBI:"disodium cromoglycate") decreases a(CHEBI:amyloid-beta) + + + + + + + pubmed:29626319 + + a(CHEBI:oleocanthal) decreases a(CHEBI:amyloid-beta) + + + + + + + pubmed:29626319 + + a(CHEBI:oleocanthal) increases p(HGNC:LRP1) + + + + + + + pubmed:29626319 + + a(CHEBI:oleocanthal) increases p(HGNC:ABCB1) + + + + + + + pubmed:29238289 + + complex(p(HGNC:MAPT), p(MESH:"Receptors, Muscarinic")) increases a(MESH:Calcium) + + + + + + + pubmed:29238289 + + complex(p(HGNC:MAPT), p(MESH:"Receptors, Muscarinic")) increases bp(GO:"apoptotic process") + + + + + + + + + pubmed:29238289 + + complex(p(HGNC:HSPA8), p(INTERPRO:"Chaperone DnaJ")) regulates tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + + + pubmed:29238289 + + p(HGNC:SNAP23) increases tloc(p(HGNC:MAPT), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:29238289 + + p(HGNC:SNAP23) isA p(MESH:"SNARE Proteins") + + + + + + + pubmed:29238289 + + p(MESH:"SNARE Proteins") increases bp(GO:exocytosis) + + + + + + + pubmed:29238289 + + p(MESH:"rab GTP-Binding Proteins") regulates act(a(MESH:"Transport Vesicles")) + + + + + + + pubmed:29238289 + + p(MESH:"rab GTP-Binding Proteins") regulates bp(MESH:"Membrane Fusion") + + + + + + + pubmed:29980653 + + p(HGNC:PRNP, var("?")) positiveCorrelation path(MESH:"Prion Diseases") + + + + + + + pubmed:29980653 + + complex(a(CONSO:"protein aggregates"), p(HGNCGENEFAMILY:Syndecans)) increases path(CONSO:Neurodegeneration) + + + + + + + pubmed:29980653 + + a(MESH:Glycosaminoglycans) association p(HGNCGENEFAMILY:Syndecans) + + + + + + + + + pubmed:29980653 + + complex(a(CONSO:"Tau aggregates"), a(MESH:Glycosaminoglycans)) increases a(CONSO:"Tau fibrils") + + + + + + + pubmed:29980653 + + complex(a(CONSO:"6-O-sulfated heparin"), a(CONSO:"Tau aggregates")) increases a(CONSO:"Tau fibrils") + + + + + + + pubmed:29980653 + + complex(a(CONSO:"Tau aggregates"), p(HGNCGENEFAMILY:Syndecans, pmod(go:0006477 ! "protein sulfation"))) increases a(CONSO:"Tau fibrils") + + + + + + + pubmed:17493042 + + p(CONSO:"tubulin-binding repeat 2") partOf p(CONSO:"microtubule-binding region") + + + + + + + pubmed:17493042 + + p(CONSO:"tubulin-binding repeat 2") isA p(INTERPRO:"Microtubule associated protein, tubulin-binding repeat") + + + + + + + pubmed:17493042 + + p(CONSO:"tubulin-binding repeat 2") equivalentTo p(CONSO:"Tau isoform F (441 aa)", frag("275_305")) + + + + + + + pubmed:23407988 + + p(CONSO:"tubulin-binding repeat 2") partOf p(CONSO:"4R tau") + + + + + + + pubmed:23407988 + + p(CONSO:"tubulin-binding repeat 2") partOf p(CONSO:"3R tau") + + + + + + + pubmed:2123288 + + p(CONSO:"tubulin-binding repeat 2") association p(FPLX:CALM) + + + + + + + pubmed:17493042 + + p(CONSO:"tubulin-binding repeat 3") partOf p(CONSO:"microtubule-binding region") + + + + + + + pubmed:17493042 + + p(CONSO:"tubulin-binding repeat 3") isA p(INTERPRO:"Microtubule associated protein, tubulin-binding repeat") + + + + + + + pubmed:17493042 + + p(CONSO:"tubulin-binding repeat 3") equivalentTo p(CONSO:"Tau isoform F (441 aa)", frag("306_336")) + + + + + + + pubmed:23407988 + + p(CONSO:"tubulin-binding repeat 3") partOf p(CONSO:"4R tau") + + + + + + + pubmed:23407988 + + p(CONSO:"tubulin-binding repeat 3") partOf p(CONSO:"3R tau") + + + + + + + pubmed:17493042 + + p(CONSO:"tubulin-binding repeat 4") partOf p(CONSO:"microtubule-binding region") + + + + + + + pubmed:17493042 + + p(CONSO:"tubulin-binding repeat 4") isA p(INTERPRO:"Microtubule associated protein, tubulin-binding repeat") + + + + + + + pubmed:17493042 + + p(CONSO:"tubulin-binding repeat 4") equivalentTo p(CONSO:"Tau isoform F (441 aa)", frag("337_368")) + + + + + + + pubmed:17493042 + + p(CONSO:"tubulin-binding repeat 4") directlyIncreases act(p(HGNC:MAPT), ma(GO:"microtubule binding")) + + + + + + + pubmed:23407988 + + p(CONSO:"tubulin-binding repeat 4") partOf p(CONSO:"4R tau") + + + + + + + + + pubmed:17493042 + + p(INTERPRO:"MAP2/Tau projection") equivalentTo p(CONSO:"projection domain") + + + + + + + pubmed:8391280 + + p(INTERPRO:"MAP2/Tau projection") association p(HGNC:DCTN1) + + + + + + + pubmed:12551948 + + p(INTERPRO:"MAP2/Tau projection") decreases bp(GO:"neuron projection development") + + + + + + + pubmed:12551948 + + p(INTERPRO:"MAP2/Tau projection") isA p(HGNC:MAPT, loc(GO:"plasma membrane")) + + + + + + + pubmed:17493042 + + p(CONSO:"Tau isoform F (441 aa)", frag("244_274")) equivalentTo p(CONSO:"tubulin-binding repeat 1") + + + + + + + pubmed:17493042 + + p(CONSO:"Tau isoform F (441 aa)", frag("275_305")) equivalentTo p(CONSO:"tubulin-binding repeat 2") + + + + + + + pubmed:17493042 + + p(CONSO:"Tau isoform F (441 aa)", frag("306_336")) equivalentTo p(CONSO:"tubulin-binding repeat 3") + + + + + + + pubmed:17493042 + + p(CONSO:"Tau isoform F (441 aa)", frag("337_368")) equivalentTo p(CONSO:"tubulin-binding repeat 4") + + + + + + + pubmed:17493042 + + p(HGNC:MAPT, frag("199_370")) equivalentTo p(CONSO:"microtubule-binding region") + + + + + + + pubmed:17493042 + + p(HGNC:MAPT, frag("1_198")) equivalentTo p(CONSO:"projection domain") + + + + + + + pubmed:17493042 + + p(INTERPRO:"Microtubule associated protein, tubulin-binding repeat", pmod(go:0006468 ! "protein phosphorylation")) decreases act(p(HGNC:MAPT), ma(GO:"microtubule binding")) + + + + + + + pubmed:17493042 + + p(FPLX:PRKG) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 214)) + + + + + + + pubmed:17493042 + + bp(MESH:Mitosis) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 214)) + + + + + + + pubmed:21757739 + + p(CONSO:"assembly domain") equivalentTo p(HGNC:MAPT, frag("199_441")) + + + + + + + pubmed:21757739 + + p(HGNC:MAPT, frag("199_441")) equivalentTo p(CONSO:"assembly domain") + + + + + + + pubmed:21757739 + + p(HGNC:MAPT, frag("244_369")) equivalentTo p(CONSO:"microtubule-binding region") + + + + + + + pubmed:21757739 + + p(HGNC:MAPT, frag("370_441")) partOf p(CONSO:"assembly domain") + + + + + + + pubmed:21757739 + + p(CONSO:"proline-rich region 2") equivalentTo p(HGNC:MAPT, frag("199_244")) + + + + + + + pubmed:21757739 + + p(CONSO:"proline-rich region 2") partOf p(CONSO:"assembly domain") + + + + + + + pubmed:21757739 + + p(CONSO:"proline-rich region 2") partOf p(CONSO:"proline-rich domain") + + + + + + + + + pubmed:21757739 + + p(HGNC:MAPT, frag("199_244")) equivalentTo p(CONSO:"proline-rich region 2") + + + + + + + pubmed:21757739 + + p(CONSO:"proline-rich domain") equivalentTo p(INTERPRO:"PSP, proline-rich") + + + + + + + pubmed:22033876 + + p(CONSO:"proline-rich domain") regulates complex(p(FPLX:Actin), p(HGNC:MAPT)) + + + + + + + pubmed:22033876 + + p(CONSO:"proline-rich domain") regulates complex(p(HGNC:MAPT), p(INTERPRO:"SH3 domain")) + + + + + + + pubmed:22033876 + + p(CONSO:"proline-rich domain") regulates complex(p(HGNC:MAPT), p(HGNCGENEFAMILY:"Src family tyrosine kinases")) + + + + + + + pubmed:22033876 + + p(CONSO:"proline-rich domain") regulates complex(p(HGNC:MAPT), p(HGNC:PLCG1)) + + + + + + + pubmed:21757739 + + p(INTERPRO:"PSP, proline-rich") equivalentTo p(CONSO:"proline-rich domain") + + + + + + + pubmed:21757739 + + p(CONSO:"proline-rich region 1") equivalentTo p(HGNC:MAPT, frag("152_198")) + + + + + + + pubmed:21757739 + + p(CONSO:"proline-rich region 1") partOf p(CONSO:"proline-rich domain") + + + + + + + pubmed:21757739 + + p(CONSO:"proline-rich region 1") partOf p(CONSO:"projection domain") + + + + + + + pubmed:21757739 + + p(HGNC:MAPT, frag("152_198")) equivalentTo p(CONSO:"proline-rich region 1") + + + + + + + pubmed:21757739 + + p(HGNC:MAPT, frag("1_151")) partOf p(CONSO:"projection domain") + + + + + + + pubmed:27260836 + + complex(p(CONSO:"AP-2 complex"), p(HGNCGENEFAMILY:"Clathrin subunits")) positiveCorrelation bp(GO:"clathrin-dependent endocytosis") + + + + + + + + + pubmed:27260836 + + p(HGNC:AP2M1) partOf p(CONSO:"AP-2 complex") + + + + + + + pubmed:27260836 + + p(HGNC:AP2B1) partOf p(CONSO:"AP-2 complex") + + + + + + + pubmed:27260836 + + p(HGNC:AP2A1) partOf p(CONSO:"AP-2 complex") + + + + + + + pubmed:27260836 + + p(HGNC:AP2A2) partOf p(CONSO:"AP-2 complex") + + + + + + + pubmed:27260836 + + p(HGNC:AP2S1) partOf p(CONSO:"AP-2 complex") + + + + + + + pubmed:27260836 + + complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")), p(HGNC:PICALM)) partOf complex(GO:"neurofibrillary tangle") + + + + + + + pubmed:27260836 + + complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")), p(HGNC:PICALM)) partOf complex(GO:"neurofibrillary tangle") + + + + + + + pubmed:27260836 + + complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")), p(HGNC:PICALM)) partOf complex(GO:"Pick body") + + + + + + + pubmed:27260836 + + complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")), p(HGNC:PICALM)) partOf complex(GO:"Cajal body") + + + + + + + pubmed:27260836 + + complex(GO:"Pick body") positiveCorrelation path(MESH:"Pick Disease of the Brain") + + + + + + + pubmed:24368848 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Pro301Leu")) increases path(MESH:"Frontotemporal Dementia") + + + + + + + pubmed:23407988 + + a(CONSO:"ghost tangles") decreases complex(GO:"dendritic tree") + + + + + + + pubmed:23407988 + + a(CONSO:"Brodmann (1909) area 36") positiveCorrelation p(CONSO:"4R tau") + + + + + + + pubmed:23407988 + + a(CONSO:"CA1 field of hippocampus") positiveCorrelation p(CONSO:"4R tau") + + + + + + + pubmed:23407988 + + a(CONSO:"CA2 field of hippocampus") positiveCorrelation p(CONSO:"4R tau") + + + + + + + pubmed:23407988 + + a(CONSO:"CA3 field of hippocampus") positiveCorrelation p(CONSO:"4R tau") + + + + + + + pubmed:23407988 + + a(CONSO:"CA4 field of hippocampus") positiveCorrelation p(CONSO:"4R tau") + + + + + + + pubmed:23407988 + + act(complex(GO:dendrite)) positiveCorrelation complex(GO:"dendritic tree") + + + + + + + pubmed:22253473 + + a(MESH:Neuropil) positiveCorrelation p(CONSO:"Tau epitope, AT8") + + + + + + + + + pubmed:23407988 + + complex(GO:"dendritic tree") positiveCorrelation act(complex(GO:dendrite)) + + + + + + + pubmed:22142809 + + p(CONSO:RAC1b) association p(HGNC:NGFR) + + + + + + + pubmed:22142809 + + p(CONSO:RAC1b) isA p(HGNC:RAC1) + + + + + + + pubmed:22142809 + + p(CONSO:RAC1b) negativeCorrelation p(HGNC:CAV2) + + + + + + + pubmed:22142809 + + p(CONSO:RAC1b) negativeCorrelation p(HGNC:GNB4) + + + + + + + pubmed:22142809 + + p(CONSO:RAC1b) negativeCorrelation p(HGNC:LIPA) + + + + + + + pubmed:22142809 + + p(CONSO:RAC1b) positiveCorrelation a(CONSO:"cerebral cortex") + + + + + + + pubmed:27087442 + + act(p(CONSO:RAC1b)) decreases bp(GO:"neuron death") + + + + + + + pubmed:22142809 + + p(HGNC:CAV2) negativeCorrelation p(CONSO:RAC1b) + + + + + + + pubmed:22142809 + + p(HGNC:CAV2) association bp(GO:"regulation of cell cycle") + + + + + + + pubmed:22142809 + + p(HGNC:CAV2) association bp(GO:"lipid metabolic process") + + + + + + + pubmed:22142809 + + p(HGNC:GNB4) negativeCorrelation p(CONSO:RAC1b) + + + + + + + pubmed:22142809 + + p(HGNC:GNB4) association bp(GO:"regulation of cell cycle") + + + + + + + pubmed:22142809 + + a(CONSO:"cerebral cortex") positiveCorrelation p(CONSO:RAC1b) + + + + + + + pubmed:1918161 + + p(HGNC:MAPT, frag("237_367")) directlyIncreases act(p(HGNC:MAPT), ma(GO:"microtubule binding")) + + + + + + + pubmed:1918161 + + p(HGNC:MAPT, frag("237_367")) equivalentTo p(CONSO:"microtubule-binding region") + + + + + + + pubmed:1918161 + + complex(GO:axon) positiveCorrelation p(HGNC:MAPT) + + + + + + + pubmed:26671985 + + act(complex(GO:axon)) negativeCorrelation p(CONSO:"phosphatase-activating domain") + + + + + + + pubmed:26671985 + + act(complex(GO:axon)) negativeCorrelation path(CONSO:neurotoxicity) + + + + + + + pubmed:1918161 + + complex(GO:"neuron projection") positiveCorrelation p(HGNC:MAPT) + + + + + + + pubmed:17187063 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Val337Met")) increases path(CONSO:Neurodegeneration) + + + + + + + pubmed:6543144 + + complex(GO:neurofilament) association p(HGNC:MAPT) + + + + + + + + + pubmed:6543144 + + complex(complex(GO:neurofilament), p(HGNC:MAPT)) association complex(GO:microtubule) + + + + + + + pubmed:11812770 + + complex(p(HGNC:GSK3B), p(HGNC:MAPT)) positiveCorrelation p(HGNC:GSK3B) + + + + + + + pubmed:11812770 + + complex(p(HGNC:GSK3B), p(HGNC:MAPT)) positiveCorrelation p(HGNC:MAPT) + + + + + + + + + + + + + pubmed:18680553 + + p(RGD:Mapt, frag("223_226")) association p(HGNC:FYN) + + + + + + + pubmed:18467332 + + p(HGNC:SRC, frag("84_145")) association p(HGNC:MAPT) + + + + + + + pubmed:18467332 + + p(HGNC:SRC, frag("84_145")) equivalentTo p(INTERPRO:"SH3 domain") + + + + + + + pubmed:18467332 + + p(INTERPRO:"SH3 domain") equivalentTo p(HGNC:SRC, frag("84_145")) + + + + + + + pubmed:18467332 + + p(INTERPRO:"SH3 domain") equivalentTo p(HGNC:PLCG1, frag("790_851")) + + + + + + + + + pubmed:18467332 + + p(HGNC:PLCG1, frag("790_851")) association p(HGNC:MAPT) + + + + + + + pubmed:18467332 + + p(HGNC:PLCG1, frag("790_851")) equivalentTo p(INTERPRO:"SH3 domain") + + + + + + + pubmed:18467332 + + p(HGNC:GRB2, frag("1_57")) association p(HGNC:MAPT) + + + + + + + pubmed:18467332 + + p(HGNC:GRB2, frag("1_57")) isA complex(p(HGNC:GRB2), p(HGNC:MAPT)) + + + + + + + pubmed:18467332 + + p(HGNC:GRB2, frag("1_57")) equivalentTo p(INTERPRO:"GRB2, N-terminal SH3 domain") + + + + + + + pubmed:18467332 + + complex(p(HGNC:GRB2), p(HGNC:MAPT)) association p(HGNC:MAPT) + + + + + + + pubmed:18467332 + + p(INTERPRO:"GRB2, N-terminal SH3 domain") equivalentTo p(HGNC:GRB2, frag("1_57")) + + + + + + + pubmed:18467332 + + p(HGNC:PIK3R1, frag("3_79")) association p(HGNC:MAPT) + + + + + + + pubmed:18467332 + + p(HGNC:PIK3R1, frag("3_79")) equivalentTo p(INTERPRO:"Phosphatidylinositol 3-kinase regulatory subunit alpha, SH3 domain") + + + + + + + pubmed:18467332 + + p(INTERPRO:"Phosphatidylinositol 3-kinase regulatory subunit alpha, SH3 domain") equivalentTo p(HGNC:PIK3R1, frag("3_79")) + + + + + + + pubmed:19491104 + + p(MGI:Mapk8ip1) association p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:19491104 + + act(p(MGI:Mapk8ip1)) negativeCorrelation p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) + + + + + + + + + pubmed:19491104 + + act(p(MGI:Klc1)) negativeCorrelation p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) + + + + + + + + + pubmed:19491104 + + complex(p(MGI:Klc1), p(MGI:Mapk8ip1)) negativeCorrelation p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) + + + + + + + + + pubmed:10464280 + + rxn(reactants(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))), products(a(CHEBI:"phosphate(3-)"), p(HGNC:MAPT))) negativeCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + + + + + pubmed:18500754 + + complex(p(HGNC:MAPT), p(INTERPRO:"Heat shock protein 70 family")) decreases complex(a(MESH:Microtubules), p(HGNC:MAPT)) + + + + + + + pubmed:18500754 + + p(INTERPRO:"Heat shock protein 70kD, C-terminal domain superfamily") association p(CONSO:"microtubule-binding region") + + + + + + + pubmed:19363271 + + a(CHEBI:juglone) increases bp(GO:"neurofibrillary tangle assembly") + + + + + + + + + + + + + pubmed:14612456 + + complex(p(HGNC:HSPA8), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")), p(HGNC:STUB1), p(HGNC:UBE2D2)) directlyIncreases p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) + + + + + + + pubmed:8391280 + + p(FPLX:Ubiquitin) association p(CONSO:"microtubule-binding region") + + + + + + + pubmed:8391280 + + p(FPLX:Ubiquitin) directlyIncreases p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) + + + + + + + + + pubmed:8391280 + + act(p(INTERPRO:"Dynein associated protein")) positiveCorrelation complex(a(MESH:Microtubules), p(INTERPRO:"Dynein associated protein")) + + + + + + + pubmed:8391280 + + complex(a(MESH:Microtubules), p(INTERPRO:"Dynein associated protein")) positiveCorrelation act(p(INTERPRO:"Dynein associated protein")) + + + + + + + pubmed:8391280 + + g(DBSNP:rs63750424) positiveCorrelation path(MESH:"Frontotemporal Dementia") + + + + + + + pubmed:8391280 + + g(DBSNP:rs63750424) negativeCorrelation complex(p(HGNC:DCTN1), p(HGNC:MAPT)) + + + + + + + + + pubmed:16176937 + + p(RGD:Klc1) isA complex(p(RGD:Klc1), p(RGD:Mapt)) + + + + + + + pubmed:16176937 + + p(RGD:Klc1) isA p(INTERPRO:"Kinesin motor domain") + + + + + + + + + pubmed:16176937 + + p(RGD:Klc2) isA complex(p(RGD:Klc2), p(RGD:Mapt)) + + + + + + + pubmed:16176937 + + p(RGD:Klc2) isA p(INTERPRO:"Kinesin motor domain") + + + + + + + + + pubmed:16176937 + + p(INTERPRO:"Kinesin motor domain") association p(RGD:Snca) + + + + + + + + + pubmed:16176937 + + p(RGD:Snca) isA complex(p(FPLX:"Cytoplasmic_dynein"), p(RGD:Snca)) + + + + + + + pubmed:16176937 + + p(RGD:Snca) association p(INTERPRO:"Kinesin motor domain") + + + + + + + + + pubmed:16176937 + + p(RGD:Snca) decreases complex(p(RGD:Klc2), p(RGD:Snca)) + + + + + + + + + pubmed:16176937 + + p(FPLX:"Cytoplasmic_dynein") isA complex(p(FPLX:"Cytoplasmic_dynein"), p(RGD:Snca)) + + + + + + + pubmed:10391244 + + p(HGNC:PIN1, frag("5_39")) association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) + + + + + + + + + pubmed:10391244 + + act(p(HGNC:PIN1, frag("5_39"))) positiveCorrelation complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)), p(HGNC:PIN1, frag("5_39"))) + + + + + + + pubmed:10391244 + + complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)), p(HGNC:PIN1, frag("5_39"))) positiveCorrelation act(p(HGNC:PIN1, frag("5_39"))) + + + + + + + pubmed:10391244 + + complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)), p(HGNC:PIN1, frag("5_39"))) association complex(GO:"neurofibrillary tangle") + + + + + + + pubmed:10391244 + + complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)), p(HGNC:PIN1, frag("5_39"))) increases act(p(HGNC:MAPT), ma(GO:"microtubule binding")) + + + + + + + pubmed:10391244 + + p(HGNC:PIN1, var("p.Tyr23Ala")) decreases act(p(HGNC:PIN1, frag("5_39"))) + + + + + + + pubmed:10391244 + + p(HGNC:PIN1, var("p.Tyr23Ala")) decreases complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)), p(HGNC:PIN1, frag("5_39"))) + + + + + + + pubmed:20133804 + + p(RGD:Fkbp4) positiveCorrelation p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + + + pubmed:20133804 + + p(RGD:Fkbp4) isA complex(p(RGD:Fkbp4), p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation"))) + + + + + + + pubmed:20133804 + + p(RGD:Fkbp4) decreases act(p(RGD:Mapt)) + + + + + + + pubmed:20133804 + + p(RGD:Fkbp4) negativeCorrelation bp(GO:"neuron projection development") + + + + + + + pubmed:20133804 + + p(HGNC:FKBP4, frag("270_386")) association p(FPLX:HSP90) + + + + + + + pubmed:20133804 + + p(HGNC:FKBP4, frag("270_386")) isA p(HGNC:FKBP4) + + + + + + + pubmed:20133804 + + p(HGNC:FKBP4, frag("270_386")) isA complex(p(FPLX:HSP90), p(HGNC:FKBP4)) + + + + + + + pubmed:20071522 + + complex(p(HGNC:AHSA1), p(HGNC:MAPT)) negativeCorrelation p(HGNC:FKBP5) + + + + + + + pubmed:20071522 + + p(HGNC:FKBP5, var("p.Phe130Ala")) increases bp(GO:"microtubule polymerization") + + + + + + + pubmed:20071522 + + p(HGNC:FKBP4, var("p.Phe130Ala")) increases bp(GO:"microtubule polymerization") + + + + + + + pubmed:2123288 + + p(FPLX:CALM) association p(CONSO:"tubulin-binding repeat 2") + + + + + + + + + pubmed:2123288 + + act(p(FPLX:CALM)) increases complex(a(CHEBI:"calcium(2+)"), p(FPLX:CALM)) + + + + + + + pubmed:2123288 + + act(p(FPLX:CALM)) decreases bp(GO:"microtubule polymerization") + + + + + + + + + + + + + pubmed:2123288 + + complex(a(CHEBI:"calcium(2+)"), p(FPLX:CALM)) isA complex(a(CHEBI:"calcium(2+)"), p(FPLX:CALM), p(HGNC:MAPT)) + + + + + + + pubmed:2123288 + + complex(p(FPLX:CALM), p(HGNC:MAPT)) isA complex(a(CHEBI:"calcium(2+)"), p(FPLX:CALM), p(HGNC:MAPT)) + + + + + + + pubmed:2123288 + + complex(a(CHEBI:"calcium(2+)"), p(FPLX:CALM), p(HGNC:MAPT)) negativeCorrelation act(p(HGNC:MAPT)) + + + + + + + pubmed:2833519 + + p(HGNC:S100B) association p(HGNC:MAPT) + + + + + + + + + pubmed:2833519 + + p(HGNC:S100B) isA complex(p(HGNC:MAPT), p(HGNC:S100B)) + + + + + + + pubmed:2833519 + + act(p(HGNC:S100B)) decreases act(p(FPLX:"CAMK2_family")) + + + + + + + pubmed:18494933 + + p(HGNC:S100B) increases act(p(HGNC:AGER)) + + + + + + + pubmed:18494933 + + p(HGNC:S100B) increases act(p(FPLX:JNK)) + + + + + + + pubmed:18494933 + + p(HGNC:S100B) increases act(p(FPLX:JNK)) + + + + + + + pubmed:18494933 + + p(HGNC:S100B) increases p(GO:"neurofibrillary tangle") + + + + + + + pubmed:18494933 + + p(HGNC:S100B) positiveCorrelation bp(GO:"inflammatory response") + + + + + + + + + pubmed:18494933 + + p(HGNC:S100B) decreases bp(GO:"Wnt signaling pathway") + + + + + + + pubmed:18494933 + + p(HGNC:S100B) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:2833519 + + complex(p(HGNC:MAPT), p(HGNC:S100B)) decreases act(p(FPLX:"CAMK2_family")) + + + + + + + pubmed:18494933 + + p(MESH:"beta Catenin") regulates bp(GO:"Wnt signaling pathway") + + + + + + + pubmed:18494933 + + p(MESH:"beta Catenin") decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:12714745 + + g(DBSNP:rs104893877) positiveCorrelation p(CONSO:"alpha-synuclein fibrils") + + + + + + + pubmed:12714745 + + g(DBSNP:rs104893877) positiveCorrelation complex(GO:"neurofibrillary tangle") + + + + + + + pubmed:12714745 + + g(DBSNP:rs104893877) positiveCorrelation complex(GO:"Lewy body") + + + + + + + pubmed:12714745 + + complex(GO:"Lewy body") positiveCorrelation g(DBSNP:rs104893877) + + + + + + + pubmed:12714745 + + composite(p(HGNC:MAPT), p(HGNC:SNCA)) increases p(CONSO:"alpha-synuclein fibrils") + + + + + + + pubmed:12714745 + + composite(p(HGNC:MAPT), p(HGNC:SNCA)) increases p(CONSO:"Tau fibrils") + + + + + + + pubmed:21339331 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Arg406Tyr")) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) + + + + + + + pubmed:21339331 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Arg406Tyr")) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 212)) + + + + + + + pubmed:21339331 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Arg406Tyr")) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) + + + + + + + pubmed:21339331 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Arg406Tyr")) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + + + + + + + pubmed:21339331 + + p(CONSO:"Tau isoform F (441 aa)", var("p.Arg406Tyr")) decreases complex(p(HGNC:ANXA2), p(HGNC:MAPT)) + + + + + + + pubmed:21339331 + + p(HGNC:ANXA2) association p(HGNC:MAPT) + + + + + + + + + pubmed:21339331 + + p(HGNC:ANXA2) isA complex(p(HGNC:ANXA2), p(HGNC:MAPT)) + + + + + + + pubmed:18096814 + + a(CHEBI:"2-bromohexadecanoic acid") decreases p(MGI:Fyn, pmod(go:0018345 ! "protein palmitoylation")) + + + + + + + pubmed:18096814 + + a(CHEBI:"2-bromohexadecanoic acid") negativeCorrelation p(MGI:Mapt, loc(GO:"membrane raft")) + + + + + + + pubmed:18096814 + + a(CHEBI:"2-bromohexadecanoic acid") negativeCorrelation p(MGI:Fyn, loc(GO:"membrane raft")) + + + + + + + pubmed:18096814 + + p(MGI:Fyn, pmod(go:0018345 ! "protein palmitoylation")) increases tloc(p(MGI:Fyn), fromLoc(GO:cytoplasm), toLoc(GO:"membrane raft")) + + + + + + + pubmed:21131359 + + bp(MESH:"Hot Temperature") increases complex(a(CHEBI:"double-stranded DNA"), p(HGNC:MAPT)) + + + + + + + pubmed:21131359 + + bp(MESH:"Hot Temperature") increases tloc(p(HGNC:MAPT), fromLoc(GO:cytoplasm), toLoc(GO:nucleus)) + + + + + + + pubmed:21131359 + + bp(MESH:"Hot Temperature") negativeCorrelation p(HGNC:MAPT) + + + + + + + pubmed:21131359 + + bp(MESH:"Hot Temperature") decreases a(CHEBI:"double-stranded DNA") + + + + + + + pubmed:8226987 + + bp(MESH:"Hot Temperature") increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:19732809 + + bp(MESH:"Hot Temperature") association p(MESH:Proteins, pmod(CONSO:O-GlcNAcylation)) + + + + + + + + + pubmed:21131359 + + a(CHEBI:"double-stranded DNA") isA complex(a(CHEBI:"double-stranded DNA"), p(HGNC:MAPT)) + + + + + + + pubmed:21131359 + + a(CHEBI:"double-stranded DNA") association p(HGNC:MAPT) + + + + + + + pubmed:8985176 + + a(CHEBI:"transfer RNA") increases bp(GO:"neurofibrillary tangle assembly") + + + + + + + pubmed:28173111 + + r(MGI:Dnm1l) positiveCorrelation path(CONSO:"mitochondrial dysfunction") + + + + + + + pubmed:28173111 + + r(MGI:Dnm1l) negativeCorrelation act(complex(GO:mitochondrion)) + + + + + + + pubmed:28173111 + + r(MGI:Dnm1l) negativeCorrelation complex(GO:mitochondrion) + + + + + + + pubmed:28173111 + + r(MGI:Dnm1l) positiveCorrelation p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:28173111 + + r(MGI:Dnm1l) negativeCorrelation bp(MESH:"Mitochondrial Dynamics") + + + + + + + pubmed:28173111 + + r(MGI:Dnm1l) negativeCorrelation act(complex(GO:"neuron to neuron synapse")) + + + + + + + pubmed:28173111 + + r(MGI:Dnm1l) negativeCorrelation r(MGI:Syp) + + + + + + + pubmed:28173111 + + r(MGI:Dnm1l) negativeCorrelation r(MGI:Dlg4) + + + + + + + pubmed:28173111 + + r(MGI:Dnm1l) negativeCorrelation r(MGI:Syn1) + + + + + + + pubmed:28173111 + + r(MGI:Dnm1l) negativeCorrelation r(MGI:Vamp1) + + + + + + + pubmed:28173111 + + r(MGI:Dnm1l) negativeCorrelation r(HGNCGENEFAMILY:"Vesicle associated membrane proteins") + + + + + + + pubmed:28173111 + + r(MGI:Dnm1l) negativeCorrelation r(MGI:Synpo) + + + + + + + pubmed:28173111 + + r(MGI:Dnm1l) negativeCorrelation r(MGI:Nrgn) + + + + + + + pubmed:28173111 + + r(MGI:Dnm1l) negativeCorrelation r(MGI:Gap43) + + + + + + + pubmed:28173111 + + r(MGI:Dnm1l) positiveCorrelation r(MGI:Fis1) + + + + + + + pubmed:28173111 + + r(MGI:Dnm1l) positiveCorrelation r(MGI:Ppid) + + + + + + + pubmed:28173111 + + r(MGI:Dnm1l) negativeCorrelation r(MGI:Mfn1) + + + + + + + pubmed:28173111 + + r(MGI:Dnm1l) negativeCorrelation r(MGI:Mfn2) + + + + + + + pubmed:28173111 + + r(MGI:Dnm1l) negativeCorrelation r(MGI:Opa1) + + + + + + + pubmed:28173111 + + r(MGI:Dnm1l) negativeCorrelation r(MGI:Nrf1) + + + + + + + pubmed:28173111 + + r(MGI:Dnm1l) negativeCorrelation r(MGI:Nfe2l2) + + + + + + + pubmed:28173111 + + r(MGI:Dnm1l) negativeCorrelation r(MGI:Ppargc1a) + + + + + + + pubmed:28173111 + + r(MGI:Dnm1l) negativeCorrelation r(MGI:Tfam) + + + + + + + pubmed:28173111 + + act(complex(GO:mitochondrion)) negativeCorrelation r(MGI:Dnm1l) + + + + + + + pubmed:28173111 + + complex(GO:mitochondrion) negativeCorrelation r(MGI:Dnm1l) + + + + + + + pubmed:28173111 + + complex(GO:mitochondrion) association p(MGI:Nrf1) + + + + + + + pubmed:28173111 + + complex(GO:mitochondrion) association p(MGI:Nfe2l2) + + + + + + + pubmed:28173111 + + complex(GO:mitochondrion) association p(MGI:Ppargc1a) + + + + + + + pubmed:28173111 + + complex(GO:mitochondrion) association p(MGI:Tfam) + + + + + + + pubmed:28173111 + + act(complex(GO:"neuron to neuron synapse")) negativeCorrelation r(MGI:Dnm1l) + + + + + + + pubmed:28173111 + + act(complex(GO:"neuron to neuron synapse")) association p(MGI:Syp) + + + + + + + pubmed:28173111 + + act(complex(GO:"neuron to neuron synapse")) association p(MGI:Dlg4) + + + + + + + pubmed:28173111 + + act(complex(GO:"neuron to neuron synapse")) association p(MGI:Syn1) + + + + + + + pubmed:28173111 + + act(complex(GO:"neuron to neuron synapse")) association p(MGI:Vamp1) + + + + + + + pubmed:28173111 + + act(complex(GO:"neuron to neuron synapse")) association p(HGNCGENEFAMILY:"Vesicle associated membrane proteins") + + + + + + + pubmed:28173111 + + act(complex(GO:"neuron to neuron synapse")) association p(MGI:Synpo) + + + + + + + pubmed:28173111 + + act(complex(GO:"neuron to neuron synapse")) association p(MGI:Nrgn) + + + + + + + pubmed:28173111 + + act(complex(GO:"neuron to neuron synapse")) association p(MGI:Gap43) + + + + + + + pubmed:28173111 + + r(MGI:Syp) negativeCorrelation r(MGI:Dnm1l) + + + + + + + pubmed:28173111 + + p(MGI:Dnm1l) negativeCorrelation p(MGI:Syp) + + + + + + + pubmed:28173111 + + p(MGI:Dnm1l) negativeCorrelation p(MGI:Dlg4) + + + + + + + pubmed:28173111 + + p(MGI:Dnm1l) negativeCorrelation p(MGI:Syn1) + + + + + + + pubmed:28173111 + + p(MGI:Dnm1l) negativeCorrelation p(MGI:Vamp1) + + + + + + + pubmed:28173111 + + p(MGI:Dnm1l) negativeCorrelation p(HGNCGENEFAMILY:"Vesicle associated membrane proteins") + + + + + + + pubmed:28173111 + + p(MGI:Dnm1l) negativeCorrelation p(MGI:Synpo) + + + + + + + pubmed:28173111 + + p(MGI:Dnm1l) negativeCorrelation p(MGI:Nrgn) + + + + + + + pubmed:28173111 + + p(MGI:Dnm1l) negativeCorrelation p(MGI:Gap43) + + + + + + + pubmed:28173111 + + p(MGI:Dnm1l) positiveCorrelation p(MGI:Fis1) + + + + + + + pubmed:28173111 + + p(MGI:Dnm1l) association bp(GO:"mitochondrial fission") + + + + + + + pubmed:28173111 + + p(MGI:Dnm1l) positiveCorrelation p(MGI:Ppid) + + + + + + + pubmed:28173111 + + p(MGI:Dnm1l) negativeCorrelation p(MGI:Mfn1) + + + + + + + pubmed:28173111 + + p(MGI:Dnm1l) negativeCorrelation p(MGI:Mfn2) + + + + + + + pubmed:28173111 + + p(MGI:Dnm1l) negativeCorrelation p(MGI:Opa1) + + + + + + + pubmed:28173111 + + p(MGI:Dnm1l) negativeCorrelation p(MGI:Nrf1) + + + + + + + pubmed:28173111 + + p(MGI:Dnm1l) negativeCorrelation p(MGI:Nfe2l2) + + + + + + + pubmed:28173111 + + p(MGI:Dnm1l) negativeCorrelation p(MGI:Ppargc1a) + + + + + + + pubmed:28173111 + + p(MGI:Dnm1l) negativeCorrelation p(MGI:Tfam) + + + + + + + pubmed:28173111 + + r(MGI:Dlg4) negativeCorrelation r(MGI:Dnm1l) + + + + + + + pubmed:28173111 + + r(MGI:Syn1) negativeCorrelation r(MGI:Dnm1l) + + + + + + + pubmed:28173111 + + p(MGI:Syn1) negativeCorrelation p(MGI:Dnm1l) + + + + + + + pubmed:28173111 + + p(MGI:Syn1) association act(complex(GO:"neuron to neuron synapse")) + + + + + + + pubmed:28173111 + + r(MGI:Vamp1) negativeCorrelation r(MGI:Dnm1l) + + + + + + + pubmed:28173111 + + p(MGI:Vamp1) negativeCorrelation p(MGI:Dnm1l) + + + + + + + pubmed:28173111 + + p(MGI:Vamp1) association act(complex(GO:"neuron to neuron synapse")) + + + + + + + pubmed:28173111 + + r(HGNCGENEFAMILY:"Vesicle associated membrane proteins") negativeCorrelation r(MGI:Dnm1l) + + + + + + + pubmed:28173111 + + p(HGNCGENEFAMILY:"Vesicle associated membrane proteins") negativeCorrelation p(MGI:Dnm1l) + + + + + + + pubmed:28173111 + + p(HGNCGENEFAMILY:"Vesicle associated membrane proteins") association act(complex(GO:"neuron to neuron synapse")) + + + + + + + pubmed:28173111 + + r(MGI:Synpo) negativeCorrelation r(MGI:Dnm1l) + + + + + + + pubmed:28173111 + + p(MGI:Synpo) negativeCorrelation p(MGI:Dnm1l) + + + + + + + pubmed:28173111 + + p(MGI:Synpo) association act(complex(GO:"neuron to neuron synapse")) + + + + + + + pubmed:28173111 + + r(MGI:Nrgn) negativeCorrelation r(MGI:Dnm1l) + + + + + + + pubmed:28173111 + + p(MGI:Nrgn) negativeCorrelation p(MGI:Dnm1l) + + + + + + + pubmed:28173111 + + p(MGI:Nrgn) association act(complex(GO:"neuron to neuron synapse")) + + + + + + + pubmed:28173111 + + r(MGI:Gap43) negativeCorrelation r(MGI:Dnm1l) + + + + + + + pubmed:28173111 + + p(MGI:Gap43) negativeCorrelation p(MGI:Dnm1l) + + + + + + + pubmed:28173111 + + p(MGI:Gap43) association act(complex(GO:"neuron to neuron synapse")) + + + + + + + pubmed:28173111 + + r(MGI:Fis1) positiveCorrelation r(MGI:Dnm1l) + + + + + + + pubmed:28173111 + + p(MGI:Fis1) positiveCorrelation p(MGI:Dnm1l) + + + + + + + pubmed:28173111 + + p(MGI:Fis1) association bp(GO:"mitochondrial fission") + + + + + + + pubmed:28173111 + + r(MGI:Ppid) positiveCorrelation r(MGI:Dnm1l) + + + + + + + pubmed:28173111 + + p(MGI:Ppid) positiveCorrelation p(MGI:Dnm1l) + + + + + + + pubmed:28173111 + + p(MGI:Ppid) association complex(GO:"mitochondrial matrix") + + + + + + + pubmed:28173111 + + complex(GO:"mitochondrial matrix") association p(MGI:Ppid) + + + + + + + pubmed:28173111 + + r(MGI:Mfn1) negativeCorrelation r(MGI:Dnm1l) + + + + + + + pubmed:28173111 + + p(MGI:Mfn1) negativeCorrelation p(MGI:Dnm1l) + + + + + + + pubmed:28173111 + + p(MGI:Mfn1) association bp(GO:"mitochondrial fusion") + + + + + + + pubmed:28173111 + + r(MGI:Mfn2) negativeCorrelation r(MGI:Dnm1l) + + + + + + + pubmed:28173111 + + p(MGI:Mfn2) negativeCorrelation p(MGI:Dnm1l) + + + + + + + pubmed:28173111 + + p(MGI:Mfn2) association bp(GO:"mitochondrial fusion") + + + + + + + pubmed:28173111 + + r(MGI:Opa1) negativeCorrelation r(MGI:Dnm1l) + + + + + + + pubmed:28173111 + + p(MGI:Opa1) negativeCorrelation p(MGI:Dnm1l) + + + + + + + pubmed:28173111 + + p(MGI:Opa1) association bp(GO:"mitochondrial fusion") + + + + + + + pubmed:28173111 + + r(MGI:Nrf1) negativeCorrelation r(MGI:Dnm1l) + + + + + + + pubmed:28173111 + + p(MGI:Nrf1) negativeCorrelation p(MGI:Dnm1l) + + + + + + + pubmed:28173111 + + p(MGI:Nrf1) association complex(GO:mitochondrion) + + + + + + + pubmed:28173111 + + r(MGI:Nfe2l2) negativeCorrelation r(MGI:Dnm1l) + + + + + + + pubmed:28173111 + + p(MGI:Nfe2l2) negativeCorrelation p(MGI:Dnm1l) + + + + + + + pubmed:28173111 + + p(MGI:Nfe2l2) association complex(GO:mitochondrion) + + + + + + + pubmed:29121589 + + p(MGI:Nfe2l2) decreases bp(GO:"inflammatory response") + + + + + + + pubmed:28173111 + + r(MGI:Ppargc1a) negativeCorrelation r(MGI:Dnm1l) + + + + + + + pubmed:28173111 + + p(MGI:Ppargc1a) negativeCorrelation p(MGI:Dnm1l) + + + + + + + pubmed:28173111 + + p(MGI:Ppargc1a) association complex(GO:mitochondrion) + + + + + + + pubmed:25987199 + + act(p(MGI:Ppargc1a)) positiveCorrelation act(a(GO:mitochondrion)) + + + + + + + pubmed:28173111 + + r(MGI:Tfam) negativeCorrelation r(MGI:Dnm1l) + + + + + + + pubmed:28173111 + + p(MGI:Tfam) negativeCorrelation p(MGI:Dnm1l) + + + + + + + pubmed:28173111 + + p(MGI:Tfam) association complex(GO:mitochondrion) + + + + + + + pubmed:25974414 + + p(HGNC:MAPT, var("p.Asp13*")) partOf a(GO:"neurofibrillary tangle") + + + + + + + pubmed:25974414 + + p(HGNC:MAPT, var("p.Asp13*")) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:25974414 + + p(HGNC:MAPT, var("p.Asp13*")) isA p(HGNC:MAPT) + + + + + + + pubmed:25974414 + + p(HGNC:MAPT, var("p.Asp25*")) partOf a(GO:"neurofibrillary tangle") + + + + + + + pubmed:25974414 + + p(HGNC:MAPT, var("p.Asp25*")) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:25974414 + + p(HGNC:MAPT, var("p.Asp368*")) partOf a(GO:"neurofibrillary tangle") + + + + + + + pubmed:25974414 + + p(HGNC:MAPT, var("p.Asp368*")) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:25974414 + + p(HGNC:MAPT, var("p.Ala2*")) isA p(HGNC:MAPT) + + + + + + + pubmed:25974414 + + p(HGNC:MAPT, pmod(CONSO:polyamination, Gln, 6)) isA p(HGNC:MAPT) + + + + + + + pubmed:25974414 + + p(HGNC:MAPT, var("p.Ala103*")) isA p(HGNC:MAPT) + + + + + + + pubmed:25974414 + + p(HGNC:MAPT, var("p.Gln124*")) isA p(HGNC:MAPT) + + + + + + + pubmed:25974414 + + p(HGNC:MAPT, var("p.Gln124*")) increases p(FPLX:Tubulin, pmod(go:0006473 ! "protein acetylation")) + + + + + + + pubmed:25974414 + + p(HGNC:MAPT, var("p.Gln124*")) increases p(INTERPRO:"Alpha tubulin", pmod(CONSO:detyrosination)) + + + + + + + pubmed:25974414 + + p(HGNC:MAPT, var("p.Gln124*")) positiveCorrelation act(p(HGNC:VASH1)) + + + + + + + pubmed:25974414 + + p(HGNC:MAPT, var("p.Gln124*")) positiveCorrelation act(p(HGNC:VASH2)) + + + + + + + pubmed:25974414 + + p(HGNC:MAPT, var("p.Met127*")) isA p(HGNC:MAPT) + + + + + + + pubmed:25974414 + + p(HGNC:MAPT, var("p.Pro172*")) isA p(HGNC:MAPT) + + + + + + + pubmed:25974414 + + p(HGNC:MAPT, var("p.Lys174*")) isA p(HGNC:MAPT) + + + + + + + pubmed:25974414 + + p(HGNC:MAPT, var("p.Lys224*")) isA p(HGNC:MAPT) + + + + + + + pubmed:25974414 + + p(HGNC:MAPT, var("p.Ser238*")) isA p(HGNC:MAPT) + + + + + + + pubmed:25974414 + + p(HGNC:MAPT, var("p.Lys240*")) isA p(HGNC:MAPT) + + + + + + + pubmed:25974414 + + p(HGNC:MAPT, var("p.Lys259*")) isA p(HGNC:MAPT) + + + + + + + pubmed:25974414 + + p(HGNC:MAPT, var("p.Gly261*")) isA p(HGNC:MAPT) + + + + + + + pubmed:25974414 + + p(HGNC:MAPT, var("p.Lys280*")) isA p(HGNC:MAPT) + + + + + + + pubmed:25974414 + + p(HGNC:MAPT, var("p.Val306*")) isA p(HGNC:MAPT) + + + + + + + pubmed:25974414 + + p(HGNC:MAPT, var("p.Ile308*")) isA p(HGNC:MAPT) + + + + + + + pubmed:25974414 + + p(HGNC:MAPT, var("p.Val309*")) isA p(HGNC:MAPT) + + + + + + + pubmed:25974414 + + p(HGNC:MAPT, var("p.Lys311*")) isA p(HGNC:MAPT) + + + + + + + pubmed:25974414 + + p(HGNC:MAPT, var("p.Lys331*")) isA p(HGNC:MAPT) + + + + + + + pubmed:25974414 + + p(HGNC:MAPT, var("p.Lys395*")) isA p(HGNC:MAPT) + + + + + + + pubmed:25974414 + + p(HGNC:MAPT, var("p.Met11*")) isA p(HGNC:MAPT) + + + + + + + pubmed:25974414 + + p(HGNC:MAPT, var("p.Glu12*")) isA p(HGNC:MAPT) + + + + + + + + + pubmed:28002468 + + p(FPLX:Tubulin) decreases p(HGNC:MAP2, pmod(go:0006473 ! "protein acetylation")) + + + + + + + pubmed:25974414 + + act(p(HGNC:VASH1)) positiveCorrelation p(HGNC:MAPT, var("p.Gln124*")) + + + + + + + pubmed:25974414 + + act(p(HGNC:VASH1)) increases p(INTERPRO:"Alpha tubulin", pmod(CONSO:detyrosination)) + + + + + + + pubmed:25974414 + + act(p(HGNC:VASH2)) positiveCorrelation p(HGNC:MAPT, var("p.Gln124*")) + + + + + + + pubmed:25974414 + + act(p(HGNC:VASH2)) increases p(INTERPRO:"Alpha tubulin", pmod(CONSO:detyrosination)) + + + + + + + pubmed:25974414 + + act(p(HGNC:TAOK2), ma(go:0016301 ! "kinase activity")) directlyIncreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:16566606 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 197)) decreases bp(GO:"tubulin complex assembly") + + + + + + + pubmed:16566606 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 197)) association p(HGNC:MAPT, pmod(CONSO:misfolded)) + + + + + + + pubmed:22057784 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 197)) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") + + + + + + + pubmed:22057784 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 197)) positiveCorrelation path(CONSO:"Corticobasal Degeneration") + + + + + + + pubmed:22057784 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 197)) partOf a(MESH:"Neuropil Threads") + + + + + + + pubmed:17050703 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 197)) isA p(HGNC:MAPT, pmod(CONSO:nitration)) + + + + + + + pubmed:16566606 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 197)) decreases bp(GO:"microtubule polymerization") + + + + + + + pubmed:16566606 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 197)) positiveCorrelation a(CONSO:"paired helical filaments") + + + + + + + pubmed:16566606 + + p(HGNC:MAPT, pmod(CONSO:nitration, Tyr, 197)) negativeCorrelation act(p(HGNC:MAPT)) + + + + + + + pubmed:24869773 + + p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 311)) association path(MESH:"Alzheimer Disease") + + + + + + + pubmed:24869773 + + p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 311)) association p(CONSO:"Tau aggregates") + + + + + + + pubmed:24869773 + + p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 259)) regulates complex(a(GO:microtubule), p(HGNC:MAPT)) + + + + + + + pubmed:24869773 + + p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 259)) isA p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys)) + + + + + + + pubmed:24869773 + + p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 290)) regulates complex(a(GO:microtubule), p(HGNC:MAPT)) + + + + + + + pubmed:24869773 + + p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 290)) isA p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys)) + + + + + + + pubmed:22033876 + + p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 290)) partOf p(CONSO:"tubulin-binding repeat 2") + + + + + + + pubmed:24869773 + + p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 353)) regulates complex(a(GO:microtubule), p(HGNC:MAPT)) + + + + + + + pubmed:24869773 + + p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 353)) isA p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys)) + + + + + + + pubmed:24869773 + + p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 24)) association p(HGNC:MAPT) + + + + + + + pubmed:24869773 + + p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 24)) isA p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys)) + + + + + + + pubmed:24869773 + + p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 44)) association p(HGNC:MAPT) + + + + + + + pubmed:24869773 + + p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 44)) isA p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys)) + + + + + + + pubmed:24869773 + + p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 67)) association p(HGNC:MAPT) + + + + + + + pubmed:24869773 + + p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 67)) isA p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys)) + + + + + + + pubmed:24869773 + + p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 190)) association p(HGNC:MAPT) + + + + + + + pubmed:24869773 + + p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 190)) isA p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys)) + + + + + + + pubmed:22033876 + + p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 163)) partOf p(CONSO:"proline-rich domain") + + + + + + + pubmed:22033876 + + p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 174)) partOf p(CONSO:"proline-rich domain") + + + + + + + pubmed:22033876 + + p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 180)) partOf p(CONSO:"proline-rich domain") + + + + + + + + + pubmed:10887109 + + p(HGNCGENEFAMILY:"Src family tyrosine kinases") increases p(HGNC:PECAM1, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:22033876 + + p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 254)) partOf p(CONSO:"tubulin-binding repeat 1") + + + + + + + pubmed:22033876 + + p(HGNC:MAPT, pmod(go:0006479 ! "protein methylation", Lys, 267)) partOf p(CONSO:"tubulin-binding repeat 1") + + + + + + + pubmed:23943618 + + complex(p(FPLX:PPP2), p(HGNC:MAPT)) positiveCorrelation act(p(FPLX:PPP2)) + + + + + + + pubmed:23943618 + + complex(p(FPLX:PPP2), p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:22764226 + + act(a(CHEBI:L-dopa)) decreases p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation")) + + + + + + + pubmed:22764226 + + act(a(CHEBI:L-dopa)) decreases p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation")) + + + + + + + pubmed:22764226 + + act(a(CHEBI:L-dopa)) decreases p(HGNC:PPP2CA, pmod(go:0006479 ! "protein methylation")) + + + + + + + pubmed:22764226 + + act(a(CHEBI:L-dopa)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) + + + + + + + pubmed:22764226 + + act(a(CHEBI:L-dopa)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + + + + + + + pubmed:22764226 + + act(a(CHEBI:L-dopa)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:22764226 + + act(a(CHEBI:L-dopa)) increases a(CHEBI:homocysteine) + + + + + + + pubmed:22764226 + + act(a(CHEBI:L-dopa)) decreases p(MGI:Ppp2ca, pmod(go:0006479 ! "protein methylation")) + + + + + + + pubmed:22764226 + + p(MGI:Ppp2ca, pmod(go:0006479 ! "protein methylation")) negativeCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) + + + + + + + pubmed:22764226 + + p(MGI:Ppp2ca, pmod(go:0006479 ! "protein methylation")) negativeCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + + + + + + + + + pubmed:25143394 + + p(MGI:Ppp2ca) negativeCorrelation p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:25681682 + + bp(MESH:"Body Mass Index") negativeCorrelation p(HGNC:AGER) + + + + + + + pubmed:24183963 + + composite(a(CHEBI:glucose), a(PUBCHEM:16132389)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) + + + + + + + pubmed:24183963 + + composite(a(CHEBI:glucose), a(PUBCHEM:16132389)) decreases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) + + + + + + + + + pubmed:24183963 + + p(HGNC:GLP1R) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) + + + + + + + pubmed:24183963 + + p(HGNC:GLP1R) increases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) + + + + + + + pubmed:25987199 + + p(HGNC:GLP1R) decreases bp(MESH:"Oxidative Stress") + + + + + + + pubmed:25987199 + + p(HGNC:GLP1R) increases act(a(GO:mitochondrion)) + + + + + + + pubmed:25987199 + + p(HGNC:GLP1R) decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:24183963 + + a(CHEBI:exendin-4) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) + + + + + + + pubmed:24183963 + + a(CHEBI:exendin-4) increases p(HGNC:GSK3B, pmod(go:0006468 ! "protein phosphorylation", Ser, 9)) + + + + + + + pubmed:23531502 + + complex(a(CHEBI:cinnamaldehydes), p(HGNC:MAPT)) decreases a(CONSO:"Tau aggregates") + + + + + + + + + + + pubmed:23531502 + + a(CHEBI:cinnamaldehydes) decreases act(a(CHEBI:"hydrogen peroxide")) + + + + + + + pubmed:23531502 + + a(CHEBI:cinnamaldehydes) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:23531502 + + complex(a(CHEBI:"(-)-epicatechin"), p(HGNC:MAPT)) decreases a(CONSO:"Tau aggregates") + + + + + + + + + pubmed:23531502 + + a(CHEBI:"(-)-epicatechin") decreases act(a(CHEBI:"hydrogen peroxide")) + + + + + + + pubmed:23531502 + + a(CHEBI:"(-)-epicatechin") decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:23531502 + + a(CHEBI:"(-)-epicatechin") decreases a(CHEBI:acrolein) + + + + + + + pubmed:23531502 + + composite(a(CHEBI:cinnamaldehydes), p(HGNC:MAPT)) causesNoChange bp(GO:"microtubule polymerization") + + + + + + + pubmed:23531502 + + act(a(CHEBI:acrolein)) association a(GO:"neurofibrillary tangle") + + + + + + + pubmed:17082178 + + a(CHEBI:acrolein) increases a(GO:"neurofibrillary tangle") + + + + + + + pubmed:23531502 + + act(a(CHEBI:acrolein)) association path(MESH:"Plaque, Amyloid") + + + + + + + pubmed:23531502 + + act(a(CHEBI:acrolein)) association a(CONSO:"dystrophic neurite") + + + + + + + pubmed:23531502 + + act(a(CHEBI:acrolein)) increases bp(GO:"neuron death") + + + + + + + pubmed:23531502 + + act(a(CHEBI:acrolein)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:23531502 + + act(a(CHEBI:acrolein)) increases act(p(HGNC:GSK3B)) + + + + + + + pubmed:23531502 + + act(a(CHEBI:acrolein)) increases act(p(HGNC:MAPK14)) + + + + + + + pubmed:23531502 + + act(a(CHEBI:acrolein)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:17082178 + + a(CHEBI:acrolein) increases complex(p(HGNC:MAPT), p(HGNC:MAPT)) + + + + + + + pubmed:17082178 + + a(CHEBI:acrolein) increases a(CONSO:"Tau oligomers") + + + + + + + pubmed:26655600 + + p(CONSO:"Tau isoform F (441 aa)", pmod(CONSO:glycation)) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:26655600 + + p(CONSO:"Tau isoform F (441 aa)", pmod(CONSO:glycation)) negativeCorrelation p(CONSO:"Tau isoform F (441 aa)", pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:26655600 + + p(CONSO:"Tau isoform C (410 aa)", pmod(CONSO:glycation)) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:26655600 + + p(CONSO:"Tau isoform B (381 aa)", pmod(CONSO:glycation)) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:26655600 + + p(CONSO:"Tau isoform B (381 aa)", pmod(CONSO:glycation)) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:26655600 + + p(CONSO:"Tau isoform F (441 aa)", pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation p(CONSO:"Tau isoform F (441 aa)", pmod(CONSO:glycation)) + + + + + + + pubmed:26655600 + + p(CONSO:"Tau isoform D (383 aa)", pmod(CONSO:glycation)) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:26655600 + + p(CONSO:"Tau isoform D (383 aa)", pmod(go:0006468 ! "protein phosphorylation")) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:26655600 + + p(CONSO:"Tau isoform E (412 aa)", pmod(CONSO:glycation)) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:26655600 + + p(CONSO:"Tau isoform E (412 aa)", pmod(go:0006468 ! "protein phosphorylation")) decreases a(CONSO:"Tau aggregates") + + + + + + + pubmed:26655600 + + p(CONSO:"Tau isoform B (381 aa)", pmod(go:0006468 ! "protein phosphorylation")) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:26304819 + + a(CHEBI:glyceraldehyde) increases r(HGNC:GAPDH) + + + + + + + pubmed:26304819 + + a(CHEBI:glyceraldehyde) increases bp(GO:"apoptotic process") + + + + + + + pubmed:26304819 + + a(CHEBI:glyceraldehyde) increases a(CONSO:GA-AGE) + + + + + + + pubmed:26304819 + + a(CHEBI:glyceraldehyde) decreases a(CHEBI:"amyloid-beta polypeptide 42") + + + + + + + pubmed:26304819 + + a(CHEBI:glyceraldehyde) increases p(HGNC:MAPT) + + + + + + + pubmed:26304819 + + a(CHEBI:glyceraldehyde) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 181)) + + + + + + + pubmed:26304819 + + a(CHEBI:glyceraldehyde) increases p(HGNC:VEGFA) + + + + + + + pubmed:26304819 + + a(CHEBI:glyceraldehyde) increases p(HGNC:TGFB1) + + + + + + + pubmed:26304819 + + r(HGNC:GAPDH) association bp(GO:"apoptotic process") + + + + + + + pubmed:26304819 + + a(CONSO:GA-AGE) isA a(CHEBI:"advanced glycation end-product") + + + + + + + pubmed:26095350 + + a(CHEBI:D-ribose) increases a(CHEBI:"advanced glycation end-product") + + + + + + + pubmed:26095350 + + a(CHEBI:D-ribose) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 214)) + + + + + + + pubmed:26095350 + + a(CHEBI:D-ribose) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) + + + + + + + pubmed:26095350 + + a(CHEBI:D-ribose) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 214), pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) + + + + + + + pubmed:26095350 + + a(CHEBI:D-ribose) increases p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:26095350 + + a(CHEBI:D-ribose) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 214)) + + + + + + + pubmed:28176663 + + a(CHEBI:D-ribose) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 214)) + + + + + + + pubmed:26095350 + + a(CHEBI:D-ribose) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) + + + + + + + pubmed:28176663 + + a(CHEBI:D-ribose) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) + + + + + + + pubmed:26095350 + + a(CHEBI:D-ribose) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 181)) + + + + + + + pubmed:28176663 + + a(CHEBI:D-ribose) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 181)) + + + + + + + pubmed:26095350 + + a(CHEBI:D-ribose) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:26095350 + + a(CHEBI:D-ribose) increases p(MGI:Camk2b, pmod(go:0006468 ! "protein phosphorylation", Thr, 286), pmod(go:0006468 ! "protein phosphorylation", Thr, 287)) + + + + + + + pubmed:26095350 + + a(CHEBI:D-ribose) decreases p(MGI:Camk2b, pmod(go:0006468 ! "protein phosphorylation", Thr, 305), pmod(go:0006468 ! "protein phosphorylation", Thr, 306)) + + + + + + + pubmed:19517062 + + a(CHEBI:D-ribose) increases p(HGNC:MAPT, pmod(CONSO:glycation)) + + + + + + + pubmed:28176663 + + a(CHEBI:D-ribose) increases a(CONSO:"advanced glycation end product") + + + + + + + pubmed:26095350 + + p(MGI:Camk2b, pmod(go:0006468 ! "protein phosphorylation", Thr, 286), pmod(go:0006468 ! "protein phosphorylation", Thr, 287)) increases act(p(MGI:Camk2b)) + + + + + + + + + + + pubmed:26095350 + + p(MGI:Camk2b, pmod(go:0006468 ! "protein phosphorylation", Thr, 305), pmod(go:0006468 ! "protein phosphorylation", Thr, 306)) decreases act(p(MGI:Camk2b)) + + + + + + + pubmed:22798221 + + a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + + + + + + + pubmed:22798221 + + a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 198)) + + + + + + + pubmed:22798221 + + a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) + + + + + + + pubmed:22798221 + + a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) + + + + + + + pubmed:22798221 + + a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) + + + + + + + pubmed:22798221 + + a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) + + + + + + + pubmed:22798221 + + a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) + + + + + + + pubmed:22798221 + + a(CHEBI:methylglyoxal) increases a(CHEBI:"advanced glycation end-product") + + + + + + + pubmed:22798221 + + a(CHEBI:methylglyoxal) increases p(HGNC:AGER) + + + + + + + pubmed:22798221 + + a(CHEBI:methylglyoxal) increases act(p(MGI:Gsk3b), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:22798221 + + a(CHEBI:methylglyoxal) increases act(p(MGI:Mapk14), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:19251756 + + a(CHEBI:methylglyoxal) negativeCorrelation act(p(INTERPRO:"Triosephosphate isomerase")) + + + + + + + pubmed:17082178 + + a(CHEBI:methylglyoxal) increases a(GO:"neurofibrillary tangle") + + + + + + + pubmed:17082178 + + a(CHEBI:methylglyoxal) increases complex(p(HGNC:MAPT), p(HGNC:MAPT)) + + + + + + + pubmed:17082178 + + a(CHEBI:methylglyoxal) increases a(CONSO:"Tau oligomers") + + + + + + + pubmed:22798221 + + act(p(MGI:Mapk14), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + + + + + + + pubmed:22798221 + + act(p(MGI:Mapk14), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 198)) + + + + + + + pubmed:22798221 + + act(p(MGI:Mapk14), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) + + + + + + + pubmed:22798221 + + act(p(MGI:Mapk14), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) + + + + + + + pubmed:22798221 + + act(p(MGI:Mapk14), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) + + + + + + + pubmed:22798221 + + act(p(MGI:Mapk14), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) + + + + + + + pubmed:22798221 + + act(p(MGI:Mapk14), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) + + + + + + + pubmed:22798221 + + act(p(MGI:Mapk14), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:19251756 + + act(p(INTERPRO:"Triosephosphate isomerase")) increases rxn(reactants(a(CHEBI:"D-glyceraldehyde 3-phosphate"), a(CHEBI:"dihydroxyacetone phosphate")), products(a(CHEBI:ATP))) + + + + + + + pubmed:19251756 + + p(INTERPRO:"Triosephosphate isomerase") partOf bp(GO:"canonical glycolysis") + + + + + + + pubmed:19251756 + + act(p(INTERPRO:"Triosephosphate isomerase")) negativeCorrelation path(CONSO:Neurodegeneration) + + + + + + + + + + + pubmed:19251756 + + act(p(INTERPRO:"Triosephosphate isomerase")) negativeCorrelation a(CHEBI:methylglyoxal) + + + + + + + + + + + + + + + pubmed:19251756 + + bp(GO:"canonical glycolysis") negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:19251756 + + bp(GO:"response to nitrosative stress") increases p(INTERPRO:"Triosephosphate isomerase", pmod(go:0017014 ! "protein nitrosylation", Tyr, 164)) + + + + + + + pubmed:19251756 + + bp(GO:"response to nitrosative stress") increases p(INTERPRO:"Triosephosphate isomerase", pmod(go:0017014 ! "protein nitrosylation", Tyr, 208)) + + + + + + + pubmed:21210655 + + bp(GO:"response to nitrosative stress") increases p(HGNC:MAPT, pmod(CONSO:formylation, Lys)) + + + + + + + pubmed:19251756 + + p(INTERPRO:"Triosephosphate isomerase", pmod(go:0017014 ! "protein nitrosylation", Tyr, 164)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:19251756 + + p(INTERPRO:"Triosephosphate isomerase", pmod(go:0017014 ! "protein nitrosylation", Tyr, 164)) decreases act(p(INTERPRO:"Triosephosphate isomerase")) + + + + + + + pubmed:19251756 + + p(INTERPRO:"Triosephosphate isomerase", pmod(go:0017014 ! "protein nitrosylation", Tyr, 164)) decreases act(p(INTERPRO:"Triosephosphate isomerase")) + + + + + + + pubmed:19251756 + + p(INTERPRO:"Triosephosphate isomerase", pmod(go:0017014 ! "protein nitrosylation", Tyr, 164)) increases a(CHEBI:methylglyoxal) + + + + + + + pubmed:19251756 + + p(INTERPRO:"Triosephosphate isomerase", pmod(go:0017014 ! "protein nitrosylation", Tyr, 208)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:19251756 + + p(INTERPRO:"Triosephosphate isomerase", pmod(go:0017014 ! "protein nitrosylation", Tyr, 208)) decreases act(p(INTERPRO:"Triosephosphate isomerase")) + + + + + + + pubmed:19251756 + + p(INTERPRO:"Triosephosphate isomerase", pmod(go:0017014 ! "protein nitrosylation", Tyr, 208)) decreases act(p(INTERPRO:"Triosephosphate isomerase")) + + + + + + + pubmed:19251756 + + p(INTERPRO:"Triosephosphate isomerase", pmod(go:0017014 ! "protein nitrosylation", Tyr, 208)) increases a(CHEBI:methylglyoxal) + + + + + + + pubmed:19251756 + + p(INTERPRO:"Triosephosphate isomerase", pmod(go:0017014 ! "protein nitrosylation")) association p(HGNC:MAPT) + + + + + + + + + pubmed:19251756 + + p(INTERPRO:"Triosephosphate isomerase", pmod(go:0017014 ! "protein nitrosylation")) partOf complex(p(HGNC:MAPT), p(INTERPRO:"Triosephosphate isomerase", pmod(go:0017014 ! "protein nitrosylation"))) + + + + + + + pubmed:19251756 + + complex(p(HGNC:MAPT), p(INTERPRO:"Triosephosphate isomerase", pmod(go:0017014 ! "protein nitrosylation"))) positiveCorrelation a(CHEBI:amyloid-beta) + + + + + + + pubmed:19251756 + + complex(p(HGNC:MAPT), p(INTERPRO:"Triosephosphate isomerase", pmod(go:0017014 ! "protein nitrosylation"))) partOf a(GO:"neurofibrillary tangle") + + + + + + + pubmed:18494933 + + complex(p(HGNC:AGER), p(HGNC:S100B)) increases p(FPLX:JNK, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:17082178 + + a(CHEBI:glyoxal) increases complex(p(HGNC:MAPT), p(HGNC:MAPT)) + + + + + + + pubmed:17082178 + + a(CHEBI:glyoxal) increases a(CONSO:"Tau oligomers") + + + + + + + pubmed:17082178 + + a(CHEBI:glyoxal) causesNoChange a(GO:"neurofibrillary tangle") + + + + + + + pubmed:17082178 + + a(CHEBI:malonaldehyde) increases complex(p(HGNC:MAPT), p(HGNC:MAPT)) + + + + + + + pubmed:17082178 + + a(CHEBI:malonaldehyde) increases a(CONSO:"Tau oligomers") + + + + + + + pubmed:17082178 + + a(CHEBI:malonaldehyde) causesNoChange a(GO:"neurofibrillary tangle") + + + + + + + pubmed:16630055 + + path(MESH:Fasting) decreases p(MGI:Mapt, pmod(CONSO:O-GlcNAcylation)) + + + + + + + pubmed:16630055 + + path(MESH:Fasting) increases p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:12578227 + + p(HGNC:TGM1) positiveCorrelation a(GO:"neurofibrillary tangle") + + + + + + + pubmed:12578227 + + p(HGNC:TGM1) isA p(ECCODE:2.3.2.13) + + + + + + + pubmed:12578227 + + p(CONSO:"TGM2 Isoform 3 (349 aa)") isA r(HGNC:TGM2) + + + + + + + pubmed:12578227 + + p(HGNC:TGM2) positiveCorrelation a(GO:"neurofibrillary tangle") + + + + + + + pubmed:12578227 + + p(HGNC:TGM2) isA p(ECCODE:2.3.2.13) + + + + + + + pubmed:10537045 + + p(HGNC:TGM2) positiveCorrelation p(HGNC:MAPT) + + + + + + + + + pubmed:10537045 + + p(HGNC:TGM2) partOf complex(p(HGNC:MAPT), p(HGNC:TGM2)) + + + + + + + pubmed:10537045 + + act(p(HGNC:TGM2)) association p(CONSO:"microtubule-binding region") + + + + + + + pubmed:11089576 + + act(p(ECCODE:2.3.2.13)) positiveCorrelation path(MESH:"Supranuclear Palsy, Progressive") + + + + + + + pubmed:11089576 + + act(p(ECCODE:2.3.2.13)) positiveCorrelation a(GO:"neurofibrillary tangle") + + + + + + + pubmed:11738469 + + act(p(ECCODE:2.3.2.13)) positiveCorrelation a(GO:"neurofibrillary tangle") + + + + + + + pubmed:8985134 + + act(p(ECCODE:2.3.2.13)) positiveCorrelation a(GO:"neurofibrillary tangle") + + + + + + + pubmed:11738469 + + act(p(ECCODE:2.3.2.13)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:8985134 + + act(p(ECCODE:2.3.2.13)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:9099822 + + act(p(HGNCGENEFAMILY:Transglutaminases)) positiveCorrelation a(GO:"neurofibrillary tangle") + + + + + + + pubmed:10537045 + + complex(p(HGNC:MAPT), p(HGNC:TGM2)) positiveCorrelation a(CHEBI:"calcium(2+)") + + + + + + + pubmed:10537045 + + a(CONSO:maitotoxin) increases a(CHEBI:"calcium(2+)") + + + + + + + pubmed:10537045 + + a(CONSO:maitotoxin) increases act(p(HGNC:TGM2)) + + + + + + + pubmed:22057784 + + p(HGNC:MAPT, pmod(go:0017014 ! "protein nitrosylation", Tyr, 29)) positiveCorrelation path(MESH:"Pick Disease of the Brain") + + + + + + + pubmed:17768677 + + p(RGD:Mapt, pmod(CONSO:nitration, Tyr, 507)) partOf a(MESH:Brain) + + + + + + + pubmed:16816118 + + a(CHEBI:linsidomine) increases a(CHEBI:peroxynitrite) + + + + + + + pubmed:16816118 + + a(CHEBI:linsidomine) decreases act(p(CONSO:"20 S Proteasome")) + + + + + + + pubmed:16816118 + + p(RGD:Mapt, pmod(CONSO:hyperphosphorylation)) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:16816118 + + p(RGD:Mapt, pmod(CONSO:nitration)) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:16816118 + + a(CHEBI:"uric acid") decreases p(RGD:Mapt, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:16816118 + + a(CHEBI:"uric acid") decreases p(RGD:Mapt, pmod(CONSO:nitration)) + + + + + + + pubmed:16816118 + + a(CHEBI:"uric acid") decreases act(a(CHEBI:peroxynitrite)) + + + + + + + pubmed:16566606 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 29)) positiveCorrelation a(GO:microtubule) + + + + + + + pubmed:16566606 + + a(CONSO:"3-3 dityrosine cross-linking") positiveCorrelation a(CONSO:"paired helical filaments") + + + + + + + pubmed:27796283 + + bp(GO:"dendritic spine development") positiveCorrelation a(MESH:"Dendritic Spines") + + + + + + + pubmed:27796283 + + p(HGNC:TIAM1, pmod(go:0006468 ! "protein phosphorylation")) increases act(p(HGNC:RAC1)) + + + + + + + pubmed:27796283 + + p(CONSO:"Kalirin 7", pmod(go:0006468 ! "protein phosphorylation", Thr, 95)) increases act(p(CONSO:"Kalirin 7")) + + + + + + + + + pubmed:27796283 + + act(p(CONSO:"Kalirin 7")) increases act(p(HGNC:RAC1)) + + + + + + + pubmed:27796283 + + p(HGNC:CAMK1) increases p(HGNC:ARHGEF7, pmod(go:0006468 ! "protein phosphorylation", Ser, 516)) + + + + + + + pubmed:27796283 + + p(HGNC:ARHGEF7, pmod(go:0006468 ! "protein phosphorylation", Ser, 516)) increases act(p(HGNC:ARHGEF7)) + + + + + + + + + pubmed:27796283 + + act(p(HGNC:ARHGEF7)) increases act(p(HGNC:RAC1)) + + + + + + + pubmed:27796283 + + complex(GO:"AMPA glutamate receptor complex") decreases act(p(HGNC:ARHGEF2)) + + + + + + + pubmed:27796283 + + complex(GO:"AMPA glutamate receptor complex") association act(p(HGNC:ARHGEF2)) + + + + + + + pubmed:27796283 + + complex(GO:"AMPA glutamate receptor complex") regulates act(p(HGNC:RHOA)) + + + + + + + pubmed:27796283 + + act(p(HGNC:ARHGEF2)) association act(p(HGNC:RHOA)) + + + + + + + pubmed:27796283 + + act(p(HGNC:ARHGEF2)) association complex(GO:"AMPA glutamate receptor complex") + + + + + + + pubmed:27796283 + + act(p(HGNC:ARHGEF2)) regulates a(MESH:"Dendritic Spines") + + + + + + + pubmed:27796283 + + act(p(HGNC:ARHGEF2)) regulates a(MESH:"Dendritic Spines") + + + + + + + + + pubmed:27796283 + + act(p(HGNC:CAMKV)) decreases complex(p(HGNC:ARHGEF2), p(HGNC:RHOA)) + + + + + + + pubmed:27796283 + + act(p(HGNC:CAMKV)) decreases act(p(HGNC:RHOA)) + + + + + + + pubmed:27796283 + + p(HGNC:CAMKV) positiveCorrelation a(MESH:"Dendritic Spines") + + + + + + + pubmed:27796283 + + act(p(HGNC:CAMKV)) regulates a(MESH:"Dendritic Spines") + + + + + + + + + pubmed:27796283 + + p(HGNC:CAMKV) regulates bp(GO:"neuron-neuron synaptic transmission") + + + + + + + pubmed:27796283 + + p(HGNC:CAMKV) association bp(MESH:"Long-Term Potentiation") + + + + + + + pubmed:27796283 + + complex(p(HGNC:ARHGEF2), p(HGNC:RHOA)) positiveCorrelation act(p(HGNC:RHOA)) + + + + + + + pubmed:27796283 + + p(HGNC:CAMKV, pmod(go:0006468 ! "protein phosphorylation", Thr, 345)) decreases act(p(HGNC:CAMKV)) + + + + + + + pubmed:29121589 + + complex(p(HGNC:CUL3), p(HGNC:KEAP1), p(HGNC:NFE2L2)) regulates p(HGNC:NFE2L2, pmod(go:0016567 ! "protein ubiquitination")) + + + + + + + pubmed:29121589 + + complex(p(HGNC:CUL3), p(HGNC:KEAP1), p(HGNC:NFE2L2)) regulates deg(p(HGNC:NFE2L2)) + + + + + + + pubmed:29121589 + + complex(p(HGNC:BTRC), p(HGNC:CUL1), p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation"))) increases p(HGNC:NFE2L2, pmod(go:0016567 ! "protein ubiquitination")) + + + + + + + pubmed:29121589 + + complex(p(HGNC:BTRC), p(HGNC:CUL1), p(HGNC:NFE2L2, pmod(go:0006468 ! "protein phosphorylation"))) increases deg(p(HGNC:NFE2L2)) + + + + + + + + + pubmed:26400044 + + p(MGI:Dpysl2, pmod(go:0006468 ! "protein phosphorylation")) partOf complex(p(CONSO:"Tau aggregates"), p(MGI:Dpysl2, pmod(go:0006468 ! "protein phosphorylation")), p(MGI:Wasf1, pmod(go:0006468 ! "protein phosphorylation"))) + + + + + + + + + pubmed:26400044 + + p(MGI:Dpysl2, pmod(go:0006468 ! "protein phosphorylation")) partOf complex(p(MGI:Dpysl2, pmod(go:0006468 ! "protein phosphorylation")), p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)), p(MGI:Wasf1, pmod(go:0006468 ! "protein phosphorylation"))) + + + + + + + + + + + pubmed:24401760 + + path(CONSO:Astrogliosis) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:29121589 + + r(MGI:Il1b) biomarkerFor bp(GO:"inflammatory response") + + + + + + + pubmed:29121589 + + r(MGI:Nos2) biomarkerFor bp(GO:"inflammatory response") + + + + + + + pubmed:27807169 + + p(RGD:Cdk5r2) directlyIncreases act(p(RGD:Cdk5)) + + + + + + + pubmed:27807169 + + p(RGD:Cdk5r2) positiveCorrelation a(GO:"dendritic spine") + + + + + + + pubmed:27807169 + + p(RGD:Cdk5r2) positiveCorrelation a(GO:axon) + + + + + + + pubmed:27807169 + + p(RGD:Cdk5r2) positiveCorrelation bp(GO:"synapse assembly") + + + + + + + + + + + pubmed:7514173 + + a(CHEBI:"glycerol 2-phosphate") decreases act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:7514173 + + a(CHEBI:"diethyl pyrocarbonate") decreases act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:7514173 + + a(CHEBI:"pyridoxal 5'-phosphate") decreases act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:7514173 + + a(CHEBI:Phenylglyoxal) decreases act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:7514173 + + a(CHEBI:"poly(lysine) polymer") decreases act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:7514173 + + a(CHEBI:"sodium chloride") decreases act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:7514173 + + a(CHEBI:"sodium fluoride") decreases act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:7514173 + + a(CHEBI:"manganese(II) chloride") decreases act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:7514173 + + a(CHEBI:"calcium dichloride") decreases act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:9089387 + + act(p(FPLX:PDH, pmod(go:0006468 ! "protein phosphorylation"))) negativeCorrelation p(FPLX:PDH, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:9089387 + + p(FPLX:PDH, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation act(p(FPLX:PDH, pmod(go:0006468 ! "protein phosphorylation"))) + + + + + + + pubmed:9089387 + + p(FPLX:PDH, pmod(go:0006468 ! "protein phosphorylation")) decreases rxn(reactants(a(CHEBI:pyruvate)), products(a(CHEBI:acetyl-CoA))) + + + + + + + + + pubmed:9089387 + + p(FPLX:PDH) partOf bp(GO:"canonical glycolysis") + + + + + + + + + + + + + pubmed:22102280 + + a(CONSO:tideglusib) decreases act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:22102280 + + a(CHEBI:hypothemycin) decreases act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:22102280 + + a(CHEBI:alsterpaullone) decreases act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:10998059 + + a(CHEBI:alsterpaullone) decreases act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:10998059 + + a(CHEBI:alsterpaullone) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:10998059 + + a(CHEBI:alsterpaullone) decreases act(p(MGI:Cdk5), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:10998059 + + a(CHEBI:alsterpaullone) decreases act(p(MGI:Cdk5r1)) + + + + + + + pubmed:10998059 + + a(CHEBI:alsterpaullone) decreases p(MGI:Ppp1r1b, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:11013232 + + a(CONSO:indirubin) decreases act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:10998059 + + act(p(MGI:Cdk5), ma(go:0016301 ! "kinase activity")) increases p(MGI:Ppp1r1b, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + + + pubmed:24808823 + + p(MGI:Cdk5) negativeCorrelation path(MESH:"Spatial Learning") + + + + + + + pubmed:24808823 + + act(p(MGI:Cdk5)) positiveCorrelation p(MGI:Ttbk1) + + + + + + + pubmed:27087442 + + p(MGI:Cdk5) decreases p(MGI:Cdk5r1) + + + + + + + pubmed:27087442 + + p(MGI:Cdk5) decreases act(p(CONSO:RAC1b)) + + + + + + + pubmed:27087442 + + p(MGI:Cdk5) decreases path(MESH:Cognition) + + + + + + + pubmed:27087442 + + p(MGI:Cdk5) increases bp(GO:"neuron death") + + + + + + + pubmed:14642273 + + act(p(MGI:Cdk5), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 175)) + + + + + + + pubmed:14642273 + + act(p(MGI:Cdk5), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 176)) + + + + + + + pubmed:14642273 + + act(p(MGI:Cdk5), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 178)) + + + + + + + pubmed:14642273 + + act(p(MGI:Cdk5), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 195)) + + + + + + + pubmed:14642273 + + act(p(MGI:Cdk5), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 198)) + + + + + + + pubmed:14642273 + + act(p(MGI:Cdk5), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) + + + + + + + pubmed:14642273 + + act(p(MGI:Cdk5), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) + + + + + + + pubmed:14642273 + + act(p(MGI:Cdk5), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) + + + + + + + pubmed:14642273 + + act(p(MGI:Cdk5), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 217)) + + + + + + + pubmed:14642273 + + act(p(MGI:Cdk5), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 220)) + + + + + + + pubmed:14642273 + + act(p(MGI:Cdk5), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 235)) + + + + + + + pubmed:14642273 + + act(p(MGI:Cdk5), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 239)) + + + + + + + pubmed:14642273 + + act(p(MGI:Cdk5), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) + + + + + + + pubmed:14642273 + + act(p(MGI:Cdk5), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 400)) + + + + + + + pubmed:14642273 + + act(p(MGI:Cdk5), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 403)) + + + + + + + + + pubmed:8702879 + + p(HGNC:SYN1, pmod(go:0006468 ! "protein phosphorylation", Ser, 551)) negativeCorrelation act(p(HGNC:SYN1)) + + + + + + + + + pubmed:8702879 + + act(p(HGNC:SYN1)) negativeCorrelation p(HGNC:SYN1, pmod(go:0006468 ! "protein phosphorylation", Ser, 551)) + + + + + + + + + + + pubmed:8702879 + + act(p(HGNC:SYN1)) negativeCorrelation p(HGNC:SYN1, pmod(go:0006468 ! "protein phosphorylation", Ser, 62)) + + + + + + + + + pubmed:8702879 + + act(p(HGNC:SYN1)) negativeCorrelation p(HGNC:SYN1, pmod(go:0006468 ! "protein phosphorylation", Ser, 67)) + + + + + + + pubmed:8702879 + + act(p(HGNC:SYN1)) increases bp(GO:"actin filament bundle assembly") + + + + + + + + + pubmed:8702879 + + p(HGNC:SYN1, pmod(go:0006468 ! "protein phosphorylation", Ser, 62)) negativeCorrelation act(p(HGNC:SYN1)) + + + + + + + pubmed:8702879 + + p(HGNC:SYN1, pmod(go:0006468 ! "protein phosphorylation", Ser, 67)) negativeCorrelation act(p(HGNC:SYN1)) + + + + + + + + + pubmed:26400044 + + p(MGI:Wasf1, pmod(go:0006468 ! "protein phosphorylation")) partOf complex(p(CONSO:"Tau aggregates"), p(MGI:Dpysl2, pmod(go:0006468 ! "protein phosphorylation")), p(MGI:Wasf1, pmod(go:0006468 ! "protein phosphorylation"))) + + + + + + + + + pubmed:26400044 + + p(MGI:Wasf1, pmod(go:0006468 ! "protein phosphorylation")) partOf complex(p(MGI:Dpysl2, pmod(go:0006468 ! "protein phosphorylation")), p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)), p(MGI:Wasf1, pmod(go:0006468 ! "protein phosphorylation"))) + + + + + + + + + + + pubmed:26400044 + + complex(p(MGI:Dpysl2, pmod(go:0006468 ! "protein phosphorylation")), p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation")), p(MGI:Wasf1, pmod(go:0006468 ! "protein phosphorylation"))) association path(MESH:"Plaque, Amyloid") + + + + + + + pubmed:8726973 + + a(CONSO:isopentanyladenine) decreases act(p(HGNC:CDK5)) + + + + + + + pubmed:8726973 + + a(CONSO:olomoucine) decreases act(p(HGNC:CDK5)) + + + + + + + pubmed:18239272 + + p(HGNC:CSNK1D) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:25673844 + + p(HGNC:CSNK1D) isA p(FPLX:CSNK1) + + + + + + + pubmed:23088643 + + p(HGNC:TTBK1) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 198)) + + + + + + + pubmed:23088643 + + p(HGNC:TTBK1) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) + + + + + + + pubmed:23088643 + + p(HGNC:TTBK1) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) + + + + + + + pubmed:23088643 + + p(HGNC:TTBK1) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 197)) + + + + + + + pubmed:23687953 + + act(p(HGNC:TTBK1), ma(go:0016301 ! "kinase activity")) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Tyr, 197)) + + + + + + + pubmed:23088643 + + p(HGNC:TTBK1) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) + + + + + + + pubmed:23088643 + + p(HGNC:TTBK1) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) + + + + + + + pubmed:23088643 + + p(HGNC:TTBK1) association a(CONSO:pretangles) + + + + + + + pubmed:23088643 + + p(HGNC:TTBK1) association a(CONSO:"Tau fibrils") + + + + + + + pubmed:20096481 + + p(HGNC:TTBK1) increases act(p(HGNC:CDK5)) + + + + + + + pubmed:20096481 + + p(HGNC:TTBK1) increases act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:25673844 + + p(HGNC:TTBK1) isA p(CONSO:"CK1 superfamily") + + + + + + + pubmed:25673844 + + p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(go:0006468 ! "protein phosphorylation", Ser, 42)) + + + + + + + pubmed:25673844 + + p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(go:0006468 ! "protein phosphorylation", Ser, 45)) + + + + + + + pubmed:25673844 + + p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(go:0006468 ! "protein phosphorylation", Ser, 47)) + + + + + + + pubmed:25673844 + + p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(go:0006468 ! "protein phosphorylation", Ser, 80)) + + + + + + + pubmed:25673844 + + p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(go:0006468 ! "protein phosphorylation", Ser, 81)) + + + + + + + pubmed:25673844 + + p(HGNC:TTBK1) increases p(HGNC:SV2A, pmod(go:0006468 ! "protein phosphorylation", Thr, 84)) + + + + + + + pubmed:25473830 + + p(HGNC:TTBK1) directlyIncreases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:25473830 + + p(HGNC:TTBK1) increases tloc(p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation")), fromLoc(GO:nucleus), toLoc(GO:cytoplasm)) + + + + + + + pubmed:20096481 + + g(DBSNP:rs2651206) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:21548880 + + g(DBSNP:rs2651206) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:20096481 + + g(DBSNP:rs2651206) association g(HGNC:TTBK1) + + + + + + + pubmed:21548880 + + g(DBSNP:rs2651206) isA g(HGNC:TTBK1) + + + + + + + pubmed:20096481 + + g(DBSNP:rs10807287) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:20096481 + + g(DBSNP:rs10807287) association g(HGNC:TTBK1) + + + + + + + pubmed:20096481 + + g(DBSNP:rs7764257) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:20096481 + + g(DBSNP:rs7764257) association g(HGNC:TTBK1) + + + + + + + pubmed:20096481 + + g(HGNC:TTBK1) association g(DBSNP:rs2651206) + + + + + + + pubmed:20096481 + + g(HGNC:TTBK1) association g(DBSNP:rs10807287) + + + + + + + pubmed:20096481 + + g(HGNC:TTBK1) association g(DBSNP:rs7764257) + + + + + + + pubmed:2820993 + + act(p(FPLX:CSNK2)) increases act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:21548880 + + p(HGNC:TTBK2, var("p.Tyr448*")) positiveCorrelation path(CONSO:"Spinocerebellar Ataxia 11") + + + + + + + pubmed:21548880 + + p(HGNC:TTBK2, var("p.Tyr448*")) increases p(HGNC:TTBK2) + + + + + + + pubmed:21548880 + + p(HGNC:TTBK2, var("p.Tyr448*")) decreases act(p(HGNC:TTBK2), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:21548880 + + path(CONSO:"Spinocerebellar Ataxia 11") positiveCorrelation p(HGNC:TTBK2, var("p.Tyr448*")) + + + + + + + pubmed:21548880 + + path(CONSO:"Spinocerebellar Ataxia 11") positiveCorrelation p(HGNC:TTBK2, var("p.Asp449*")) + + + + + + + pubmed:21548880 + + path(CONSO:"Spinocerebellar Ataxia 11") positiveCorrelation p(HGNC:TTBK2, var("p.Glu450*")) + + + + + + + pubmed:21548880 + + p(HGNC:TTBK2, var("p.Asp449*")) positiveCorrelation path(CONSO:"Spinocerebellar Ataxia 11") + + + + + + + pubmed:21548880 + + p(HGNC:TTBK2, var("p.Asp449*")) increases p(HGNC:TTBK2) + + + + + + + pubmed:21548880 + + p(HGNC:TTBK2, var("p.Asp449*")) decreases act(p(HGNC:TTBK2), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:21548880 + + p(HGNC:TTBK2, var("p.Glu450*")) positiveCorrelation path(CONSO:"Spinocerebellar Ataxia 11") + + + + + + + pubmed:21548880 + + p(HGNC:TTBK2, var("p.Glu450*")) increases p(HGNC:TTBK2) + + + + + + + pubmed:21548880 + + p(HGNC:TTBK2, var("p.Glu450*")) decreases act(p(HGNC:TTBK2), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:19118186 + + p(MGI:Ttbk1) increases p(MGI:Cdk5r1) + + + + + + + pubmed:19118186 + + p(MGI:Ttbk1) positiveCorrelation act(p(ECCODE:3.4.22.52)) + + + + + + + pubmed:19118186 + + p(MGI:Ttbk1) negativeCorrelation p(MGI:Grin2b) + + + + + + + pubmed:19118186 + + p(MGI:Ttbk1) negativeCorrelation p(MGI:Grin2d) + + + + + + + pubmed:19118186 + + p(MGI:Ttbk1) negativeCorrelation p(MGI:Capn1) + + + + + + + pubmed:24808823 + + p(MGI:Ttbk1) negativeCorrelation path(MESH:"Spatial Learning") + + + + + + + pubmed:24808823 + + p(MGI:Ttbk1) increases a(CONSO:pretangles) + + + + + + + pubmed:24808823 + + p(MGI:Ttbk1) increases deg(a(MESH:"Motor Neurons")) + + + + + + + pubmed:24808823 + + p(MGI:Ttbk1) increases bp(GO:"neuroinflammatory response") + + + + + + + pubmed:24808823 + + p(MGI:Ttbk1) positiveCorrelation act(p(MGI:Cdk5)) + + + + + + + pubmed:19118186 + + act(p(ECCODE:3.4.22.52)) positiveCorrelation p(MGI:Ttbk1) + + + + + + + pubmed:19118186 + + p(MGI:Grin2b) negativeCorrelation p(MGI:Ttbk1) + + + + + + + pubmed:24808823 + + tloc(p(MGI:Grin2b), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) positiveCorrelation path(MESH:"Spatial Learning") + + + + + + + + + pubmed:19118186 + + p(MGI:Grin2d) negativeCorrelation p(MGI:Ttbk1) + + + + + + + pubmed:19118186 + + complex(p(MGI:Cdk5), p(MGI:Cdk5r1)) negativeCorrelation complex(a(GO:"filamentous actin"), p(MGI:Cdk5r1)) + + + + + + + pubmed:19118186 + + complex(p(MGI:Cdk5), p(MGI:Cdk5r1)) negativeCorrelation complex(GO:"filamentous actin") + + + + + + + pubmed:19118186 + + complex(a(GO:"filamentous actin"), p(MGI:Cdk5r1)) negativeCorrelation complex(p(MGI:Cdk5), p(MGI:Cdk5r1)) + + + + + + + pubmed:25673844 + + p(HGNC:VRK1) isA p(CONSO:"CK1 superfamily") + + + + + + + pubmed:25673844 + + p(HGNC:VRK2) isA p(CONSO:"CK1 superfamily") + + + + + + + pubmed:25673844 + + p(HGNC:VRK3) isA p(CONSO:"CK1 superfamily") + + + + + + + pubmed:25673844 + + p(HGNC:CSNK1A1L) isA p(FPLX:CSNK1) + + + + + + + pubmed:25673844 + + p(HGNC:CSNK1E) isA p(FPLX:CSNK1) + + + + + + + pubmed:25673844 + + p(HGNC:CSNK1G1) isA p(FPLX:CSNK1) + + + + + + + pubmed:25673844 + + p(HGNC:CSNK1G2) isA p(FPLX:CSNK1) + + + + + + + pubmed:25673844 + + p(HGNC:CSNK1G3) isA p(FPLX:CSNK1) + + + + + + + + + + + + + + + + + + + + + + + pubmed:25673844 + + p(HGNC:SV2A, pmod(go:0006468 ! "protein phosphorylation", Thr, 84)) increases complex(p(HGNC:SV2A), p(HGNC:SYT1)) + + + + + + + + + + + pubmed:27607061 + + act(p(HGNC:GRIK2)) positiveCorrelation tloc(p(HGNC:GRIK2), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) + + + + + + + pubmed:27607061 + + tloc(p(HGNC:GRIK2), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) positiveCorrelation act(p(HGNC:GRIK2)) + + + + + + + pubmed:27607061 + + tloc(p(HGNC:GRIK2), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) negativeCorrelation act(p(HGNC:RAB5A)) + + + + + + + pubmed:27607061 + + tloc(p(HGNC:GRIK2), fromLoc(go:0005622 ! intracellular), toLoc(go:0009986 ! "cell surface")) negativeCorrelation path(CONSO:Excitotoxicity) + + + + + + + pubmed:26323690 + + complex(p(HGNC:MAPRE1), p(HGNC:TTBK2)) increases p(HGNC:KIF2A, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:26323690 + + p(HGNC:KIF2A, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation bp(GO:"microtubule depolymerization") + + + + + + + + + pubmed:26323690 + + complex(p(HGNC:MAPRE3), p(HGNC:TTBK2)) increases p(HGNC:KIF2A, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + + + pubmed:22814243 + + act(p(HGNC:SLC5A1)) positiveCorrelation bp(GO:"glucose transmembrane transport") + + + + + + + pubmed:22814243 + + bp(GO:"glucose transmembrane transport") positiveCorrelation act(p(HGNC:SLC5A1)) + + + + + + + pubmed:25297623 + + p(HGNC:CEP164) association p(HGNC:TTBK2) + + + + + + + pubmed:25297623 + + p(HGNC:CEP164) increases p(HGNC:TTBK2, loc(GO:centriole)) + + + + + + + + + pubmed:25297623 + + p(HGNC:CEP164) partOf complex(p(HGNC:CEP164), p(HGNC:TTBK2)) + + + + + + + + + + + pubmed:25297623 + + p(HGNC:CEP164) partOf complex(p(HGNC:CEP164), p(HGNC:DVL3)) + + + + + + + pubmed:25297623 + + complex(p(HGNC:CEP164), p(HGNC:TTBK2)) increases act(p(HGNC:TTBK2)) + + + + + + + pubmed:25297623 + + p(HGNC:CEP164, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation complex(p(HGNC:CEP164), p(HGNC:DVL3)) + + + + + + + + + pubmed:25297623 + + complex(p(HGNC:CEP164), p(HGNC:DVL3)) negativeCorrelation p(HGNC:CEP164, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + + + pubmed:25297623 + + p(HGNC:DVL3) partOf complex(p(HGNC:CEP164), p(HGNC:DVL3)) + + + + + + + pubmed:25297623 + + p(HGNC:DVL3) regulates bp(GO:"cytosolic ciliogenesis") + + + + + + + pubmed:11943212 + + p(HGNC:MAPK11) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 181)) + + + + + + + pubmed:11943212 + + p(HGNC:MAPK11) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) + + + + + + + pubmed:11943212 + + p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 181)) + + + + + + + pubmed:11943212 + + p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) + + + + + + + pubmed:11943212 + + p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) + + + + + + + pubmed:11943212 + + p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 396)) + + + + + + + pubmed:11943212 + + p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + + + + + + + pubmed:11943212 + + p(HGNC:MAPK12) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) + + + + + + + pubmed:11943212 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 396)) partOf p(CONSO:"Tau epitope, AD2") + + + + + + + pubmed:26751493 + + complex(p(CONSO:"projection domain"), p(HGNC:LCK)) association bp(GO:"cell-cell signaling") + + + + + + + pubmed:26751493 + + complex(p(CONSO:"projection domain"), p(HGNC:FGR)) association bp(GO:"cell-cell signaling") + + + + + + + pubmed:26751493 + + complex(p(CONSO:"projection domain"), p(HGNC:SRC)) association bp(GO:"cell-cell signaling") + + + + + + + pubmed:26751493 + + complex(p(CONSO:"projection domain"), p(HGNC:GRB2)) association bp(GO:"cell-cell signaling") + + + + + + + pubmed:26751493 + + complex(p(CONSO:"projection domain"), p(FPLX:PLC)) association bp(GO:"cell-cell signaling") + + + + + + + pubmed:26751493 + + complex(a(CHEBI:phosphatidylinositol), p(CONSO:"projection domain")) association bp(GO:"cell-cell signaling") + + + + + + + pubmed:26751493 + + complex(a(CHEBI:"phosphatidylinositol bisphosphate"), p(CONSO:"projection domain")) association bp(GO:"cell-cell signaling") + + + + + + + pubmed:26751493 + + complex(p(CONSO:"projection domain"), p(HGNC:PIN1)) association bp(GO:"cell-cell signaling") + + + + + + + pubmed:26751493 + + p(INTERPRO:"Syntaxin, N-terminal domain") negativeCorrelation a(GO:"neurofibrillary tangle") + + + + + + + pubmed:11943212 + + p(HGNC:MARK4, pmod(go:0006468 ! "protein phosphorylation")) association p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) + + + + + + + + + + + pubmed:22692785 + + p(HGNC:MARK4) negativeCorrelation p(CONSO:PrPSc) + + + + + + + pubmed:22156579 + + p(HGNC:MARK4) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) + + + + + + + pubmed:23666762 + + p(HGNC:MARK4) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) + + + + + + + pubmed:27708431 + + p(HGNC:MARK4) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) + + + + + + + pubmed:22156579 + + p(HGNC:MARK4) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 356)) + + + + + + + + + pubmed:23666762 + + p(HGNC:MARK4) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:22156579 + + p(HGNC:MARK4) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:22156579 + + p(HGNC:MARK4) negativeCorrelation act(p(RGD:Dlg4)) + + + + + + + pubmed:22156579 + + p(HGNC:MARK4) negativeCorrelation p(RGD:Gria1) + + + + + + + pubmed:22156579 + + p(HGNC:MARK4) negativeCorrelation a(GO:"dendritic spine") + + + + + + + pubmed:22156579 + + p(HGNC:MARK4) negativeCorrelation a(GO:synapse) + + + + + + + pubmed:11943212 + + complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)), p(HGNC:MARK4, pmod(go:0006468 ! "protein phosphorylation"))) association path(CONSO:"granulovacuolar degeneration") + + + + + + + pubmed:22692785 + + p(CONSO:PrP106-126) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) + + + + + + + pubmed:16973293 + + p(CONSO:"MARK4 isoform 2 (688 aa)") positiveCorrelation bp(GO:"neuron development") + + + + + + + pubmed:16973293 + + p(CONSO:"MARK4 isoform 2 (688 aa)") isA p(HGNC:MARK4) + + + + + + + + + + + pubmed:23666762 + + complex(p(HGNC:MAPT), p(HGNC:MARK1)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) + + + + + + + pubmed:23666762 + + complex(p(HGNC:MAPT), p(HGNC:MARK2)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) + + + + + + + pubmed:23666762 + + complex(p(HGNC:MAPT), p(HGNC:MARK3)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) + + + + + + + + + pubmed:23666762 + + complex(p(HGNC:MAPT), p(HGNC:MARK4)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) + + + + + + + pubmed:23666762 + + complex(p(HGNC:MAPT), p(HGNC:MARK4)) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:23666762 + + p(CONSO:"CagA peptide") decreases act(p(HGNC:MARK4), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:23666762 + + p(CONSO:"CagA peptide") decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) + + + + + + + pubmed:27798139 + + act(p(MGI:Dapk1)) increases a(GO:synapse) + + + + + + + pubmed:27798139 + + act(p(MGI:Dapk1)) decreases path(MESH:"Spatial Learning") + + + + + + + pubmed:27798139 + + act(p(MGI:Dapk1)) decreases bp(GO:memory) + + + + + + + + + pubmed:25995053 + + act(p(MGI:Dapk1), ma(go:0016301 ! "kinase activity")) directlyIncreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) + + + + + + + pubmed:27094130 + + p(HGNC:DAPK1) increases tloc(p(HGNC:APP, frag("672_713")), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:27094130 + + act(p(HGNC:DAPK1), ma(go:0016301 ! "kinase activity")) positiveCorrelation tloc(p(HGNC:APP, frag("672_713")), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:27094130 + + act(p(HGNC:DAPK1), ma(go:0016301 ! "kinase activity")) increases p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation", Thr, 668)) + + + + + + + pubmed:27094130 + + act(p(HGNC:DAPK1), ma(go:0016301 ! "kinase activity")) increases p(HGNC:APP, pmod(go:0006468 ! "protein phosphorylation", Thr, 668)) + + + + + + + + + + + + + + + + + pubmed:27068745 + + act(p(HGNC:DAPK1)) increases bp(GO:"neuron apoptotic process") + + + + + + + + + pubmed:27795443 + + act(p(HGNC:DAPK1)) negativeCorrelation act(p(HGNC:JUND)) + + + + + + + pubmed:27795443 + + act(p(HGNC:DAPK1)) increases bp(GO:"apoptotic process") + + + + + + + pubmed:24853415 + + p(HGNC:DAPK1) increases p(HGNC:PIN1, pmod(go:0006468 ! "protein phosphorylation", Ser, 71)) + + + + + + + pubmed:24853415 + + p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) + + + + + + + pubmed:23948915 + + p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) + + + + + + + pubmed:21311567 + + act(p(HGNC:DAPK1), ma(go:0016301 ! "kinase activity")) directlyIncreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) + + + + + + + pubmed:24853415 + + p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) + + + + + + + pubmed:23948915 + + p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) + + + + + + + pubmed:24853415 + + p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) + + + + + + + pubmed:23948915 + + p(HGNC:DAPK1) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) + + + + + + + pubmed:24853415 + + p(HGNC:DAPK1) positiveCorrelation p(HGNC:MAPT) + + + + + + + pubmed:21311567 + + p(HGNC:DAPK1) directlyIncreases act(p(HGNC:MARK1)) + + + + + + + pubmed:21311567 + + p(HGNC:DAPK1) directlyIncreases act(p(HGNC:MARK2)) + + + + + + + pubmed:21311567 + + p(HGNC:DAPK1) decreases bp(GO:"microtubule polymerization") + + + + + + + + + pubmed:27094130 + + p(HGNC:DAPK1, frag("637_1423")) partOf p(HGNC:DAPK1) + + + + + + + + + pubmed:27094130 + + p(HGNC:DAPK1, frag("848_1423")) partOf p(HGNC:DAPK1) + + + + + + + + + pubmed:27094130 + + p(HGNC:DAPK1, frag("1271_1423")) equivalentTo p(INTERPRO:"Death domain") + + + + + + + pubmed:27094130 + + p(INTERPRO:"Death domain") equivalentTo p(HGNC:DAPK1, frag("1271_1423")) + + + + + + + pubmed:27094130 + + p(INTERPRO:"Death domain") partOf p(HGNC:DAPK1) + + + + + + + pubmed:27068745 + + p(HGNC:UNC5B) increases act(p(HGNC:DAPK1)) + + + + + + + pubmed:27068745 + + p(HGNC:UNC5B) positiveCorrelation act(p(FPLX:PPP2), ma(go:0016791 ! "phosphatase activity")) + + + + + + + pubmed:27068745 + + act(p(HGNC:DAPK1, pmod(go:0006468 ! "protein phosphorylation"))) decreases act(p(HGNC:DAPK1)) + + + + + + + pubmed:27068745 + + p(HGNC:UNC5C) positiveCorrelation bp(GO:"neuron apoptotic process") + + + + + + + + + pubmed:27068745 + + p(HGNC:UNC5C, var("p.Thr835Met")) increases bp(GO:"neuron apoptotic process") + + + + + + + pubmed:27068745 + + p(HGNC:UNC5C, var("p.Thr835Met")) positiveCorrelation act(p(HGNC:PRKD1)) + + + + + + + pubmed:27068745 + + p(HGNC:CALML5) decreases bp(GO:"neuron apoptotic process") + + + + + + + pubmed:27068745 + + act(p(HGNC:PRKD1)) positiveCorrelation p(HGNC:UNC5C, var("p.Thr835Met")) + + + + + + + pubmed:27068745 + + act(p(HGNC:PRKD1)) positiveCorrelation act(p(HGNC:MAP3K5)) + + + + + + + pubmed:27068745 + + p(ECCODE:1.6.3.1) positiveCorrelation act(p(FPLX:JNK)) + + + + + + + pubmed:27795443 + + act(p(HGNC:JUND)) decreases bp(GO:"apoptotic process") + + + + + + + pubmed:27795443 + + act(p(HGNC:JUND)) negativeCorrelation act(p(HGNC:DAPK1)) + + + + + + + pubmed:27795443 + + act(p(HGNC:CSK), ma(go:0016301 ! "kinase activity")) increases p(HGNC:DAPK1, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:27795443 + + act(p(HGNC:CSK), ma(go:0016301 ! "kinase activity")) decreases act(p(HGNC:DAPK1)) + + + + + + + pubmed:27133022 + + p(CONSO:"DAPK, basic loop (BL) motif") partOf p(HGNC:DAPK2) + + + + + + + pubmed:27133022 + + p(CONSO:"DAPK, basic loop (BL) motif") positiveCorrelation act(p(HGNC:DAPK2)) + + + + + + + pubmed:27133022 + + p(CONSO:"DAPK, basic loop (BL) motif") positiveCorrelation complex(p(FPLX:CALM), p(HGNC:DAPK2)) + + + + + + + pubmed:27133022 + + p(CONSO:"DAPK, basic loop (BL) motif") positiveCorrelation complex(a(CHEBI:"calcium(2+)"), p(HGNC:DAPK2)) + + + + + + + pubmed:27133022 + + act(p(HGNC:DAPK2)) positiveCorrelation p(CONSO:"DAPK, basic loop (BL) motif") + + + + + + + + + + + pubmed:27133022 + + complex(p(FPLX:CALM), p(HGNC:DAPK2)) positiveCorrelation p(CONSO:"DAPK, basic loop (BL) motif") + + + + + + + pubmed:27133022 + + complex(a(CHEBI:"calcium(2+)"), p(HGNC:DAPK2)) positiveCorrelation p(CONSO:"DAPK, basic loop (BL) motif") + + + + + + + pubmed:25995053 + + complex(p(MGI:Dapk1), p(MGI:Mapt)) decreases a(GO:"dendritic spine") + + + + + + + pubmed:25995053 + + complex(p(MGI:Dapk1), p(MGI:Mapt)) increases bp(GO:"neuron apoptotic process") + + + + + + + pubmed:24853415 + + p(HGNC:PIN1, pmod(go:0006468 ! "protein phosphorylation", Ser, 71)) decreases act(p(HGNC:PIN1)) + + + + + + + pubmed:22926167 + + p(HGNC:PIN1, pmod(go:0006468 ! "protein phosphorylation", Ser, 71)) decreases p(HGNC:PIN1) + + + + + + + pubmed:24853415 + + p(HGNC:PIN1, pmod(go:0006468 ! "protein phosphorylation", Ser, 71)) positiveCorrelation p(HGNC:MAPT) + + + + + + + pubmed:28137862 + + p(MGI:Dcaf1) association p(MGI:Dyrk1a) + + + + + + + + + pubmed:28137862 + + p(MGI:Dcaf1) partOf complex(p(MGI:Dcaf1), p(MGI:Dyrk1a)) + + + + + + + pubmed:28137862 + + p(MGI:Dcaf1) association p(MGI:Hap1) + + + + + + + pubmed:28137862 + + p(MGI:Dyrk1a) association p(MGI:Dcaf1) + + + + + + + + + pubmed:28137862 + + p(MGI:Dyrk1a) partOf complex(p(MGI:Dcaf1), p(MGI:Dyrk1a)) + + + + + + + pubmed:28137862 + + p(MGI:Dyrk1a) negativeCorrelation p(MGI:Hap1) + + + + + + + pubmed:29221819 + + p(MGI:Dyrk1a) negativeCorrelation a(CONSO:"granular layer of cerebellar cortex") + + + + + + + pubmed:29221819 + + p(MGI:Dyrk1a) negativeCorrelation a(CONSO:"molecular layer of cerebellar cortex") + + + + + + + pubmed:29221819 + + p(MGI:Dyrk1a) negativeCorrelation a(CONSO:"Purkinje cell layer of cerebellar cortex") + + + + + + + pubmed:29221819 + + p(MGI:Dyrk1a) negativeCorrelation bp(GO:"dendrite arborization") + + + + + + + pubmed:29221819 + + p(MGI:Dyrk1a) positiveCorrelation bp(GO:"cellular senescence") + + + + + + + pubmed:29221819 + + p(MGI:Dyrk1a) positiveCorrelation path(HP:Neurodegeneration) + + + + + + + pubmed:29221819 + + p(MGI:Dyrk1a) positiveCorrelation p(MGI:App) + + + + + + + pubmed:29221819 + + p(MGI:Dyrk1a) positiveCorrelation a(CHEBI:amyloid-beta) + + + + + + + pubmed:29221819 + + p(MGI:Dyrk1a) positiveCorrelation p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) + + + + + + + pubmed:29221819 + + p(MGI:Dyrk1a) positiveCorrelation p(MGI:Mapt) + + + + + + + pubmed:28540658 + + p(MGI:Dyrk1a) decreases a(CHEBI:serotonin) + + + + + + + pubmed:28540658 + + p(MGI:Dyrk1a) decreases a(CHEBI:dopamine) + + + + + + + pubmed:28540658 + + p(MGI:Dyrk1a) decreases a(CHEBI:adrenaline) + + + + + + + pubmed:28775333 + + p(MGI:Dyrk1a) positiveCorrelation p(CONSO:"3R tau") + + + + + + + pubmed:28775333 + + p(MGI:Dyrk1a) negativeCorrelation p(CONSO:"4R tau") + + + + + + + pubmed:28775333 + + p(MGI:Dyrk1a) positiveCorrelation path(MESH:Anxiety) + + + + + + + pubmed:28775333 + + p(MGI:Dyrk1a) negativeCorrelation bp(GO:memory) + + + + + + + pubmed:28137862 + + complex(p(MGI:Dcaf1), p(MGI:Dyrk1a)) negativeCorrelation p(MGI:Hap1) + + + + + + + pubmed:28137862 + + p(MGI:Hap1) association p(MGI:Dcaf1) + + + + + + + pubmed:28137862 + + p(MGI:Hap1) negativeCorrelation p(MGI:Dyrk1a) + + + + + + + pubmed:28137862 + + p(MGI:Hap1) negativeCorrelation complex(p(MGI:Dcaf1), p(MGI:Dyrk1a)) + + + + + + + pubmed:29221819 + + a(CONSO:"granular layer of cerebellar cortex") negativeCorrelation p(MGI:Dyrk1a) + + + + + + + pubmed:29221819 + + a(CONSO:"molecular layer of cerebellar cortex") negativeCorrelation p(MGI:Dyrk1a) + + + + + + + pubmed:29221819 + + bp(GO:"dendrite arborization") negativeCorrelation p(MGI:Dyrk1a) + + + + + + + pubmed:28884684 + + a(CONSO:ID-8) decreases act(p(HGNC:DYRK1B), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:28884684 + + a(CONSO:ID-8) decreases act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:28884684 + + a(CONSO:ID-8) decreases act(p(HGNC:DYRK1A), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:28884684 + + a(CONSO:ID-8) decreases bp(GO:"neuron differentiation") + + + + + + + pubmed:28250274 + + a(CHEBI:harmine) decreases p(HGNC:DYRK1A) + + + + + + + pubmed:28250274 + + a(CHEBI:harmine) increases p(HGNC:MME) + + + + + + + + + pubmed:29077046 + + a(CHEBI:harmine) increases complex(a(CHEBI:harmine), g(HGNC:DYRK1A)) + + + + + + + pubmed:28775333 + + p(MGI:Mef2d) increases r(MGI:Dyrk1a) + + + + + + + pubmed:28775333 + + p(MGI:Mef2d) increases act(p(MGI:Dyrk1a), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:28632203 + + composite(a(CHEBI:homocysteine), p(HGNC:BDNF), p(HGNC:DYRK1A)) biomarkerFor path(MESH:"Alzheimer Disease") + + + + + + + pubmed:28167836 + + p(HGNC:DYRK1A, var("p.Arg205del")) decreases act(p(HGNC:DYRK1A)) + + + + + + + pubmed:28167836 + + p(HGNC:DYRK1A, var("p.Glu239del")) decreases act(p(HGNC:DYRK1A)) + + + + + + + + + pubmed:18070606 + + p(RGD:Syk) increases p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation", Tyr, 18)) + + + + + + + pubmed:26501932 + + a(CHEBI:"1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate") partOf a(GO:"synaptic vesicle") + + + + + + + pubmed:26501932 + + a(CHEBI:"1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate") partOf a(CONSO:"GVD bodies") + + + + + + + pubmed:26501932 + + a(CHEBI:"1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate") partOf a(CONSO:pretangles) + + + + + + + pubmed:25331948 + + a(PUBCHEM:10200390) directlyDecreases act(p(HGNC:SYK)) + + + + + + + pubmed:28176663 + + a(CONSO:"Braak_Stage V") negativeCorrelation act(p(HGNC:GSK3B), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:28176663 + + a(CONSO:"advanced glycation end product") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 181)) + + + + + + + pubmed:28176663 + + a(CONSO:"advanced glycation end product") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 214)) + + + + + + + pubmed:28176663 + + a(CONSO:"advanced glycation end product") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) + + + + + + + pubmed:25987199 + + act(a(CONSO:"advanced glycation end product")) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:26118667 + + p(HGNC:CDK5R1, frag("99_307")) equivalentTo p(CONSO:"CDK5R1 p25") + + + + + + + pubmed:26118667 + + path(CONSO:"Chronic cerebral hypoperfusion") increases p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) + + + + + + + pubmed:26118667 + + path(CONSO:"Chronic cerebral hypoperfusion") increases p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) + + + + + + + pubmed:26118667 + + path(CONSO:"Chronic cerebral hypoperfusion") increases p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) + + + + + + + pubmed:26118667 + + path(CONSO:"Chronic cerebral hypoperfusion") increases p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) + + + + + + + pubmed:26118667 + + path(CONSO:"Chronic cerebral hypoperfusion") increases p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) + + + + + + + pubmed:26118667 + + path(CONSO:"Chronic cerebral hypoperfusion") increases p(CONSO:"CDK5R1 p25") + + + + + + + pubmed:26118667 + + path(CONSO:"Chronic cerebral hypoperfusion") increases p(FPLX:NFkappaB) + + + + + + + pubmed:26118667 + + m(MIRBASE:rno-mir-195) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) + + + + + + + pubmed:26118667 + + m(MIRBASE:rno-mir-195) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) + + + + + + + pubmed:26118667 + + m(MIRBASE:rno-mir-195) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) + + + + + + + pubmed:26118667 + + m(MIRBASE:rno-mir-195) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) + + + + + + + pubmed:26118667 + + m(MIRBASE:rno-mir-195) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) + + + + + + + pubmed:26118667 + + m(MIRBASE:rno-mir-195) decreases act(p(CONSO:"CDK5R1 p25")) + + + + + + + + + pubmed:26118667 + + m(MIRBASE:rno-mir-195) increases complex(g(RGD:Cdk5r1), m(MIRBASE:rno-mir-195)) + + + + + + + pubmed:26118667 + + m(MIRBASE:rno-mir-195) decreases p(RGD:App) + + + + + + + pubmed:26118667 + + m(MIRBASE:rno-mir-195) decreases p(RGD:Bace1) + + + + + + + pubmed:26118667 + + m(MIRBASE:rno-mir-195) decreases a(CHEBI:amyloid-beta) + + + + + + + pubmed:26118667 + + m(MIRBASE:rno-mir-195) decreases p(RGD:Cdk5r1) + + + + + + + pubmed:26118667 + + complex(g(RGD:Cdk5r1), m(MIRBASE:rno-mir-195)) decreases r(RGD:Cdk5r1) + + + + + + + + + pubmed:26118667 + + complex(g(MIRBASE:rno-mir-195), p(FPLX:NFkappaB)) decreases m(MIRBASE:rno-mir-195) + + + + + + + + + + + + + pubmed:26118667 + + rxn(reactants(p(RGD:Cdk5r1)), products(p(CONSO:"CDK5R1 p25"))) positiveCorrelation act(p(FPLX:CAPN)) + + + + + + + pubmed:25987199 + + act(p(MGI:Glp1r)) regulates act(p(MGI:Ppargc1a)) + + + + + + + pubmed:25987199 + + act(p(MGI:Glp1r)) decreases act(p(MGI:Gsk3b), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:25987199 + + act(p(MGI:Glp1r)) decreases p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:25125464 + + a(PUBCHEM:9821250) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) + + + + + + + pubmed:25125464 + + a(PUBCHEM:9821250) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Thr, 204)) + + + + + + + pubmed:25125464 + + a(PUBCHEM:9821250) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) + + + + + + + pubmed:25125464 + + a(PUBCHEM:9821250) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + + + + + + + pubmed:25125464 + + a(PUBCHEM:9821250) causesNoChange p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) + + + + + + + pubmed:25125464 + + a(PUBCHEM:9821250) causesNoChange p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) + + + + + + + pubmed:25125464 + + a(PUBCHEM:9821250) decreases p(FPLX:JNK, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + + + + + + + pubmed:25125464 + + a(GO:"neuron spine") positiveCorrelation p(MGI:Fyn) + + + + + + + pubmed:22833681 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 214)) partOf p(CONSO:"Tau epitope, AT100") + + + + + + + pubmed:23294633 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 214)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) + + + + + + + pubmed:22833681 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 212)) partOf p(CONSO:"Tau epitope, AT100") + + + + + + + pubmed:23294633 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 212)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) + + + + + + + pubmed:22833681 + + path(CONSO:"Long-Term Depression") positiveCorrelation act(a(MESH:"Receptors, N-Methyl-D-Aspartate")) + + + + + + + pubmed:22833681 + + a(CONSO:"Thiamet G") directlyDecreases act(p(ECCODE:3.2.1.169)) + + + + + + + pubmed:22833681 + + act(p(ECCODE:3.2.1.169)) increases p(HGNC:MAPT, pmod(CONSO:O-GlcNAcylation)) + + + + + + + pubmed:23294633 + + p(MGI:Gsk3b, pmod(go:0006468 ! "protein phosphorylation", Tyr, 279)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) + + + + + + + pubmed:23294633 + + p(MGI:Gsk3b, pmod(go:0006468 ! "protein phosphorylation", Tyr, 279)) increases act(p(MGI:Gsk3b), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:23294633 + + p(MGI:Gsk3b, pmod(go:0006468 ! "protein phosphorylation", Tyr, 216)) positiveCorrelation p(HGNC:MAPT, var("p.Pro301Leu")) + + + + + + + pubmed:23294633 + + p(MGI:Gsk3b, pmod(go:0006468 ! "protein phosphorylation", Tyr, 216)) increases act(p(MGI:Gsk3b), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:22002427 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 205)) positiveCorrelation p(HGNC:MAPT, var("p.Glu391*")) + + + + + + + pubmed:24251416 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 352)) partOf p(CONSO:"tubulin-binding repeat 4") + + + + + + + pubmed:22156579 + + act(p(RGD:Dlg4)) negativeCorrelation p(HGNC:MARK4) + + + + + + + pubmed:22156579 + + p(RGD:Gria1) negativeCorrelation p(HGNC:MARK4) + + + + + + + pubmed:23722080 + + a(CHEBI:"sodium azide") directlyDecreases a(GO:mitochondrion) + + + + + + + + + pubmed:23722080 + + a(CHEBI:"sodium azide") positiveCorrelation composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) + + + + + + + pubmed:23722080 + + composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) positiveCorrelation a(CHEBI:"sodium azide") + + + + + + + pubmed:23722080 + + composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) positiveCorrelation a(CHEBI:"hydrogen peroxide") + + + + + + + pubmed:23722080 + + composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) increases a(CHEBI:"glutamate(1-)") + + + + + + + pubmed:23722080 + + composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) increases p(RGD:Gsk3b, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:23722080 + + composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) increases p(RGD:Mapt, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:23722080 + + composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) increases p(RGD:Bace1) + + + + + + + pubmed:23722080 + + composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) increases p(CONSO:"CDK5R1 p25") + + + + + + + pubmed:23722080 + + composite(a(CHEBI:"hydrogen peroxide"), a(CHEBI:"sodium azide")) decreases bp(GO:"cellular metabolic process") + + + + + + + pubmed:29421605 + + p(RGD:Gsk3b, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation bp(GO:aging) + + + + + + + pubmed:23722080 + + composite(a(CHEBI:"L-ascorbic acid"), a(CHEBI:Trolox), a(CHEBI:glutathione)) decreases p(RGD:Mapt, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:23722080 + + composite(a(CHEBI:"L-ascorbic acid"), a(CHEBI:Trolox), a(CHEBI:glutathione)) increases bp(GO:"cellular metabolic process") + + + + + + + + + + + pubmed:22952452 + + p(HGNC:TRAK1) increases bp(GO:"axonal transport of mitochondrion") + + + + + + + pubmed:22952452 + + p(HGNC:TRAK1) decreases path(CONSO:Neurodegeneration) + + + + + + + pubmed:22952452 + + p(HGNC:TRAK1) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) + + + + + + + pubmed:22952452 + + p(HGNC:TRAK1) decreases act(p(HGNC:MARK1)) + + + + + + + pubmed:23001711 + + p(HGNC:CHEK2) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 262)) + + + + + + + pubmed:22072628 + + p(CONSO:"proline-rich region 2", pmod(go:0006468 ! "protein phosphorylation")) positiveCorrelation bp(MESH:"Protein Conformation, alpha-Helical") + + + + + + + pubmed:22072628 + + p(HGNC:MAPT, frag("235_324")) association bp(MESH:"Protein Conformation, alpha-Helical") + + + + + + + pubmed:8226987 + + p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 261)) decreases complex(a(MESH:Microtubules), p(HGNC:MAPT)) + + + + + + + pubmed:24401760 + + p(HGNC:ITPKB) positiveCorrelation path(MESH:"Plaque, Amyloid") + + + + + + + pubmed:24401760 + + p(HGNC:ITPKB) positiveCorrelation a(CONSO:"dystrophic neurite") + + + + + + + pubmed:24401760 + + p(MGI:Itpkb) increases bp(GO:"apoptotic process") + + + + + + + pubmed:24401760 + + p(MGI:Itpkb) increases act(p(MGI:Bace1)) + + + + + + + pubmed:24401760 + + p(MGI:Itpkb) increases act(p(MGI:Map2k1)) + + + + + + + pubmed:24401760 + + p(MGI:Itpkb) increases act(p(MGI:Map2k2)) + + + + + + + pubmed:24401760 + + p(MGI:Itpkb) increases path(CONSO:Astrogliosis) + + + + + + + pubmed:24401760 + + p(MGI:Itpkb) increases p(HGNC:APP, frag("672_711")) + + + + + + + pubmed:24401760 + + p(MGI:Itpkb) increases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:24401760 + + a(PUBCHEM:9549284) directlyDecreases p(MGI:Map2k1) + + + + + + + pubmed:24401760 + + a(PUBCHEM:9549284) directlyDecreases p(MGI:Map2k2) + + + + + + + pubmed:24401760 + + a(PUBCHEM:9549284) decreases a(CHEBI:amyloid-beta) + + + + + + + pubmed:23737518 + + a(PUBCHEM:54581340) directlyDecreases act(p(RGD:Cdk5)) + + + + + + + pubmed:23737518 + + a(PUBCHEM:54581340) decreases p(CONSO:"Tau epitope, PHF1") + + + + + + + pubmed:23737518 + + a(PUBCHEM:54581340) decreases act(p(CONSO:"CDK5R1 p25")) + + + + + + + pubmed:23737518 + + a(PUBCHEM:54581340) directlyDecreases act(p(RGD:Gsk3b)) + + + + + + + pubmed:23737518 + + a(PUBCHEM:54581340) isA a(CONSO:diaminothiazole) + + + + + + + pubmed:23737518 + + a(CONSO:diaminothiazole) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + + + + + + + pubmed:23737518 + + a(CONSO:diaminothiazole) increases bp(GO:memory) + + + + + + + pubmed:23737518 + + a(CONSO:LDN-193665) isA a(CONSO:diaminothiazole) + + + + + + + pubmed:23737518 + + a(CONSO:LDN-193665) directlyDecreases act(p(RGD:Cdk5)) + + + + + + + pubmed:23737518 + + a(CONSO:LDN-193665) directlyDecreases act(p(RGD:Gsk3b)) + + + + + + + pubmed:23737518 + + a(CONSO:LDN-213843) isA a(CONSO:diaminothiazole) + + + + + + + pubmed:23737518 + + a(CONSO:LDN-213843) directlyDecreases act(p(RGD:Cdk5)) + + + + + + + pubmed:23737518 + + a(CONSO:LDN-213843) directlyDecreases act(p(RGD:Gsk3b)) + + + + + + + pubmed:7667312 + + p(HGNC:MAPT, var("p.Cys291Ala")) decreases a(CONSO:"paired helical filaments") + + + + + + + pubmed:7667312 + + a(CONSO:"Thioflavin S") positiveCorrelation a(CONSO:"paired helical filaments") + + + + + + + pubmed:25672970 + + a(CONSO:C-30-27) directlyDecreases act(p(HGNC:KAT2B)) + + + + + + + pubmed:25672970 + + a(CONSO:C-30-27) decreases p(FPLX:NFkappaB, pmod(go:0006473 ! "protein acetylation", Lys, 122)) + + + + + + + pubmed:25672970 + + a(CONSO:C-30-27) decreases bp(GO:"neuroinflammatory response") + + + + + + + pubmed:25672970 + + a(CONSO:C-30-27) increases path(MESH:Cognition) + + + + + + + pubmed:25672970 + + a(CONSO:C-30-27) increases bp(GO:locomotion) + + + + + + + pubmed:25672970 + + a(CONSO:C-30-27) increases bp(GO:"synaptic transmission, cholinergic") + + + + + + + pubmed:27917100 + + a(CONSO:ST7612AA1) directlyDecreases act(p(FPLX:HDAC)) + + + + + + + pubmed:26890116 + + a(CONSO:"Biphenyl-4-yl-acrylohydroxamoc acids") directlyDecreases act(p(FPLX:HDAC)) + + + + + + + pubmed:18558669 + + a(CONSO:Trithiocarbonates) directlyDecreases act(p(HGNC:HDAC6)) + + + + + + + pubmed:29540553 + + p(MGI:Sirt3) decreases p(HGNC:MAPT) + + + + + + + pubmed:29540553 + + p(MGI:Sirt3) decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) + + + + + + + pubmed:29540553 + + p(MGI:Sirt3) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:27550730 + + a(PUBCHEM:136299192) directlyDecreases act(p(MGI:Pde5a)) + + + + + + + pubmed:27550730 + + a(PUBCHEM:136299192) directlyDecreases act(p(FPLX:HDAC)) + + + + + + + pubmed:27550730 + + a(PUBCHEM:136299192) increases bp(GO:"long-term synaptic potentiation") + + + + + + + pubmed:27550730 + + a(PUBCHEM:136299192) decreases a(CHEBI:amyloid-beta) + + + + + + + pubmed:27550730 + + a(PUBCHEM:136299192) decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:27550730 + + a(PUBCHEM:136299192) decreases act(p(MGI:Gsk3b), ma(go:0016301 ! "kinase activity")) + + + + + + + pubmed:27550730 + + act(p(HGNC:PDE5A)) negativeCorrelation act(p(FPLX:CREB)) + + + + + + + pubmed:29559585 + + p(MGI:Gapdh, pmod(go:0017014 ! "protein nitrosylation")) increases p(MGI:Ep300, pmod(go:0006473 ! "protein acetylation")) + + + + + + + pubmed:29559585 + + p(MGI:Gapdh, pmod(go:0017014 ! "protein nitrosylation")) increases act(p(MGI:Ep300)) + + + + + + + pubmed:29559585 + + p(MGI:Gapdh, pmod(go:0017014 ! "protein nitrosylation")) increases p(MGI:Sirt1, pmod(go:0017014 ! "protein nitrosylation")) + + + + + + + pubmed:29559585 + + p(MGI:Gapdh, pmod(go:0017014 ! "protein nitrosylation")) decreases act(p(MGI:Sirt1)) + + + + + + + + + pubmed:29559585 + + p(HGNC:GAPDH, pmod(go:0017014 ! "protein nitrosylation")) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:29559585 + + a(PUBCHEM:6419718) decreases p(MGI:Gapdh, pmod(go:0017014 ! "protein nitrosylation")) + + + + + + + pubmed:29559585 + + a(PUBCHEM:6419718) decreases p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 280)) + + + + + + + pubmed:29559585 + + a(PUBCHEM:6419718) increases bp(GO:memory) + + + + + + + pubmed:29559585 + + a(PUBCHEM:6419718) increases bp(GO:locomotion) + + + + + + + pubmed:28855586 + + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 163), pmod(go:0006473 ! "protein acetylation", Lys, 280), pmod(go:0006473 ! "protein acetylation", Lys, 281), pmod(go:0006473 ! "protein acetylation", Lys, 369)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:28855586 + + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 163), pmod(go:0006473 ! "protein acetylation", Lys, 280), pmod(go:0006473 ! "protein acetylation", Lys, 281), pmod(go:0006473 ! "protein acetylation", Lys, 369)) decreases complex(a(MESH:Microtubules), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) + + + + + + + pubmed:28855586 + + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 163), pmod(go:0006473 ! "protein acetylation", Lys, 280), pmod(go:0006473 ! "protein acetylation", Lys, 281), pmod(go:0006473 ! "protein acetylation", Lys, 369)) negativeCorrelation act(a(CHEBI:amyloid-beta)) + + + + + + + pubmed:19401603 + + complex(a(MESH:Microtubules), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:28287136 + + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280), pmod(go:0006473 ! "protein acetylation", Lys, 281)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202), pmod(go:0006468 ! "protein phosphorylation", Thr, 205)) + + + + + + + pubmed:28287136 + + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280), pmod(go:0006473 ! "protein acetylation", Lys, 281)) decreases complex(a(MESH:Microtubules), p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"))) + + + + + + + pubmed:28287136 + + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 280), pmod(go:0006473 ! "protein acetylation", Lys, 281)) increases a(CONSO:"Tau aggregates") + + + + + + + pubmed:28002468 + + p(HGNC:MAP4, frag("992_999")) equivalentTo p(CONSO:"VQIINK motif") + + + + + + + + + + + pubmed:28002468 + + p(HGNC:MAP4, frag("1023_1030")) equivalentTo p(CONSO:"VQIINK motif") + + + + + + + pubmed:28002468 + + p(HGNC:MAP2, frag("332_339")) equivalentTo p(CONSO:"VQIVYK motif") + + + + + + + pubmed:28002468 + + bp(CONSO:"cystein-dependent auto-acetylation") increases p(HGNC:MAP2, pmod(go:0006473 ! "protein acetylation")) + + + + + + + pubmed:27041503 + + p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 281)) decreases bp(MESH:"Long-Term Potentiation") + + + + + + + pubmed:27041503 + + p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 281)) decreases p(MGI:Wwc1) + + + + + + + pubmed:27041503 + + p(MGI:Mapt, pmod(go:0006473 ! "protein acetylation", Lys, 281)) decreases bp(GO:"actin cytoskeleton reorganization") + + + + + + + pubmed:27041503 + + p(MGI:Wwc1) increases bp(MESH:"Long-Term Potentiation") + + + + + + + pubmed:26390242 + + a(CHEBI:salsalate) directlyDecreases act(p(HGNC:EP300)) + + + + + + + pubmed:26390242 + + a(CHEBI:salsalate) decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 174)) + + + + + + + pubmed:26390242 + + a(CHEBI:salsalate) decreases p(HGNC:MAPT) + + + + + + + pubmed:26390242 + + a(CHEBI:salsalate) increases bp(GO:memory) + + + + + + + pubmed:26390242 + + a(CHEBI:salsalate) decreases path(CONSO:Neurodegeneration) + + + + + + + pubmed:26390242 + + a(CHEBI:salicylate) directlyDecreases act(p(HGNC:EP300)) + + + + + + + pubmed:26390242 + + a(CHEBI:salicylate) decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 174)) + + + + + + + pubmed:26390242 + + a(CHEBI:salicylate) decreases p(HGNC:MAPT) + + + + + + + pubmed:26390242 + + a(CHEBI:salicylate) increases bp(GO:memory) + + + + + + + pubmed:26390242 + + a(CHEBI:salicylate) decreases path(CONSO:Neurodegeneration) + + + + + + + pubmed:26192747 + + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 225)) isA p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) + + + + + + + pubmed:26192747 + + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 317)) isA p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) + + + + + + + pubmed:26192747 + + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 317)) partOf p(CONSO:"microtubule-binding region") + + + + + + + pubmed:26192747 + + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 331)) isA p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) + + + + + + + pubmed:26192747 + + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 331)) partOf p(CONSO:"microtubule-binding region") + + + + + + + pubmed:26192747 + + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 343)) isA p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) + + + + + + + pubmed:26192747 + + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 343)) partOf p(CONSO:"microtubule-binding region") + + + + + + + pubmed:26192747 + + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 347)) isA p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) + + + + + + + pubmed:26192747 + + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 347)) partOf p(CONSO:"microtubule-binding region") + + + + + + + pubmed:26192747 + + p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation", Lys, 385)) isA p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) + + + + + + + pubmed:24686445 + + path(CONSO:"peripheral nervous system injury") increases act(p(FPLX:ERK)) + + + + + + + pubmed:20869593 + + a(CHEBI:C646) directlyDecreases act(p(HGNC:EP300)) + + + + + + + pubmed:20869593 + + a(CHEBI:C646) decreases p(HGNC:MAPT, pmod(go:0006473 ! "protein acetylation")) + + + + + + + pubmed:29226865 + + p(HGNC:SRSF2, pmod(go:0006473 ! "protein acetylation", Lys, 52)) positiveCorrelation act(p(HGNC:SRSF2)) + + + + + + + pubmed:28771976 + + a(PUBCHEM:56650312) directlyDecreases act(p(HGNC:HDAC3)) + + + + + + + pubmed:28771976 + + a(CONSO:RGFP966) association bp(GO:memory) + + + + + + + pubmed:29844403 + + p(INTERPRO:"Heat shock protein Hsp90 family", pmod(go:0006473 ! "protein acetylation")) decreases complex(p(HGNC:HDAC6), p(INTERPRO:"Heat shock protein Hsp90 family")) + + + + + + + pubmed:29844403 + + p(INTERPRO:"Heat shock protein Hsp90 family", pmod(go:0006473 ! "protein acetylation")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation"), pmod(go:0016567 ! "protein ubiquitination")) + + + + + + + pubmed:19732809 + + g(HGNC:OGA, var("?")) decreases act(complex(GO:"proteasome complex")) + + + + + + + pubmed:19732809 + + g(HGNC:OGA, var("?")) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + + + pubmed:26041011 + + a(CONSO:"USP14 Aptamer") decreases act(p(HGNC:USP14)) + + + + + + + pubmed:27325702 + + p(CONSO:"APP, ACR") association p(HGNC:STUB1) + + + + + + + pubmed:27325702 + + p(CONSO:"APP, ACR") association p(CONSO:"CRL4 complex") + + + + + + + pubmed:27325702 + + p(CONSO:"APP, ACR") increases p(HGNC:SCAMP1, pmod(go:0016567 ! "protein ubiquitination")) + + + + + + + pubmed:27325702 + + p(CONSO:"APP, ACR") increases p(HGNC:SV2A, pmod(go:0016567 ! "protein ubiquitination")) + + + + + + + pubmed:27325702 + + p(CONSO:"APP, ACR") increases p(HGNC:SV2B, pmod(go:0016567 ! "protein ubiquitination")) + + + + + + + pubmed:27325702 + + p(CONSO:"APP, ACR") increases p(HGNC:VAMP2, pmod(go:0016567 ! "protein ubiquitination")) + + + + + + + pubmed:27325702 + + p(CONSO:"APP, ACR") increases p(HGNC:ATP6V0A1, pmod(go:0016567 ! "protein ubiquitination")) + + + + + + + pubmed:27325702 + + p(CONSO:"APP, ACR") increases p(HGNC:SLC17A7, pmod(go:0016567 ! "protein ubiquitination")) + + + + + + + pubmed:27325702 + + p(CONSO:"APP, ACR") increases p(HGNC:SYT1, pmod(go:0016567 ! "protein ubiquitination")) + + + + + + + pubmed:27325702 + + p(CONSO:"APP, ACR") increases p(HGNC:SYT2, pmod(go:0016567 ! "protein ubiquitination")) + + + + + + + pubmed:27325702 + + p(CONSO:"APP, ACR") increases p(HGNC:RAB14, pmod(go:0016567 ! "protein ubiquitination")) + + + + + + + pubmed:27325702 + + p(CONSO:"APP, ACR") increases p(HGNC:SNAP25, pmod(go:0016567 ! "protein ubiquitination")) + + + + + + + pubmed:27325702 + + p(CONSO:"APP, ACR") increases p(HGNC:SYN2, pmod(go:0016567 ! "protein ubiquitination")) + + + + + + + pubmed:27325702 + + p(CONSO:"APP, ACR") increases p(HGNC:SYN1, pmod(go:0016567 ! "protein ubiquitination")) + + + + + + + pubmed:27325702 + + p(CONSO:"APP, ACR") increases p(HGNC:RAB3A, pmod(go:0016567 ! "protein ubiquitination")) + + + + + + + pubmed:27325702 + + p(CONSO:"APP, ACR") increases p(HGNC:APOE, pmod(go:0016567 ! "protein ubiquitination")) + + + + + + + pubmed:27325702 + + p(CONSO:"APP, ACR") increases p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) + + + + + + + pubmed:27325702 + + p(CONSO:"APP, ACR") regulates complex(GO:"ubiquitin ligase complex") + + + + + + + pubmed:27325702 + + p(CONSO:"CRL4 complex") association p(CONSO:"APP, ACR") + + + + + + + pubmed:27325702 + + p(CONSO:"CRL4 complex") equivalentTo complex(p(HGNC:CRBN), p(HGNC:CUL4A), p(HGNC:CUL4B), p(HGNC:DDB1)) + + + + + + + pubmed:27325702 + + p(CONSO:"CRL4 complex") isA complex(GO:"ubiquitin ligase complex") + + + + + + + pubmed:27325702 + + complex(p(HGNC:CRBN), p(HGNC:CUL4A), p(HGNC:CUL4B), p(HGNC:DDB1)) equivalentTo p(CONSO:"CRL4 complex") + + + + + + + + + + + + + + + + + + + + + + + + + + + pubmed:25378699 + + p(HGNC:MAPT, pmod(go:0016925 ! "protein sumoylation", Lys, 340)) positiveCorrelation p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:25378699 + + p(HGNC:MAPT, pmod(go:0016925 ! "protein sumoylation", Lys, 340)) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:25378699 + + p(HGNC:MAPT, pmod(go:0016925 ! "protein sumoylation", Lys, 340)) decreases p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination")) + + + + + + + pubmed:8391280 + + p(HGNC:MAPT, pmod(go:0016567 ! "protein ubiquitination", Lys, 257)) positiveCorrelation a(CONSO:"paired helical filaments") + + + + + + + pubmed:27260838 + + p(CONSO:"Tau antibody, TNT1") association p(CONSO:"phosphatase-activating domain") + + + + + + + pubmed:27260838 + + p(CONSO:"Tau antibody, TNT2") association p(CONSO:"phosphatase-activating domain") + + + + + + + pubmed:27601475 + + a(CONSO:8-nitro-cGMP) decreases a(CONSO:"Tau oligomers") + + + + + + + pubmed:27601475 + + a(CONSO:8-nitro-cGMP) positiveCorrelation a(CHEBI:"nitric oxide") + + + + + + + pubmed:27601475 + + act(p(ECCODE:1.14.13.39)) directlyIncreases a(CHEBI:"nitric oxide") + + + + + + + pubmed:27373205 + + p(CONSO:"Tau dimers") positiveCorrelation p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 422)) + + + + + + + pubmed:11606569 + + g(DBSNP:rs63750688) equivalentTo p(HGNC:MAPT, var("p.Lys280del")) + + + + + + + pubmed:19765634 + + g(DBSNP:rs761059) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:19765634 + + g(DBSNP:rs8052688) positiveCorrelation path(MESH:"Cognitive Dysfunction") + + + + + + + pubmed:19765634 + + g(DBSNP:rs8063) positiveCorrelation path(MESH:"Cognitive Dysfunction") + + + + + + + pubmed:21843595 + + p(MGI:Sumo3) negativeCorrelation bp(GO:learning) + + + + + + + pubmed:21843595 + + p(MGI:Sumo3) negativeCorrelation bp(GO:memory) + + + + + + + pubmed:19782030 + + act(p(RGD:Stat1)) increases r(RGD:Irf1) + + + + + + + pubmed:19782030 + + act(p(RGD:Stat1)) increases r(RGD:Tnf) + + + + + + + pubmed:19782030 + + act(p(RGD:Stat1)) increases r(RGD:Il6) + + + + + + + + + + + + + + + pubmed:19782030 + + p(RGD:Pias1) increases p(RGD:Nr1h2, pmod(go:0016925 ! "protein sumoylation")) + + + + + + + + + + + + + pubmed:19782030 + + p(RGD:Hdac4) increases p(RGD:Nr1h3, pmod(go:0016925 ! "protein sumoylation")) + + + + + + + + + + + pubmed:19782030 + + p(RGD:Nr1h2, pmod(go:0016925 ! "protein sumoylation")) increases act(p(RGD:Stat1)) + + + + + + + pubmed:19782030 + + p(RGD:Nr1h3, pmod(go:0016925 ! "protein sumoylation")) increases act(p(RGD:Stat1)) + + + + + + + pubmed:19323834 + + complex(p(FPLX:CEBP), p(HGNC:SUMO1)) directlyDecreases r(HGNC:NOS2) + + + + + + + + + pubmed:19323834 + + p(FPLX:CEBP) partOf complex(p(FPLX:CEBP), p(HGNC:SUMO1)) + + + + + + + pubmed:19323834 + + p(HGNC:SENP1) directlyDecreases r(HGNC:NOS2) + + + + + + + pubmed:18675254 + + p(HGNC:APP, pmod(go:0016925 ! "protein sumoylation", Lys, 587)) negativeCorrelation a(CHEBI:amyloid-beta) + + + + + + + pubmed:18675254 + + p(HGNC:APP, pmod(go:0016925 ! "protein sumoylation", Lys, 595)) negativeCorrelation a(CHEBI:amyloid-beta) + + + + + + + pubmed:18675254 + + complex(GO:"endoplasmic reticulum") association p(HGNC:UBE2I) + + + + + + + pubmed:16464864 + + a(CHEBI:colchicine) increases p(HGNC:MAPT, pmod(go:0016925 ! "protein sumoylation", Lys, 340)) + + + + + + + pubmed:12506199 + + p(HGNC:SUMO3, var("p.Lys11Arg")) increases p(HGNC:APP, pmod(go:0016925 ! "protein sumoylation")) + + + + + + + pubmed:12506199 + + p(HGNC:SUMO3, var("p.Lys11Arg")) increases a(CHEBI:amyloid-beta) + + + + + + + pubmed:12506199 + + p(HGNC:APP, pmod(go:0016925 ! "protein sumoylation")) increases a(CHEBI:amyloid-beta) + + + + + + + pubmed:12506199 + + p(HGNC:APP, pmod(CONSO:polysumoylation)) decreases a(CHEBI:amyloid-beta) + + + + + + + pubmed:29334120 + + p(HGNC:PPP1CC) directlyDecreases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation", Ser, 403)) + + + + + + + pubmed:29334120 + + p(HGNC:PPP1CC) directlyDecreases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + + + + + + + pubmed:29334120 + + p(HGNC:PPP1CC) directlyDecreases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation", Ser, 409)) + + + + + + + pubmed:29334120 + + p(HGNC:PPP1CC) directlyDecreases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation", Ser, 410)) + + + + + + + pubmed:29334120 + + p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation", Ser, 409)) increases act(p(HGNC:TARDBP)) + + + + + + + pubmed:29334120 + + p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation", Ser, 410)) increases act(p(HGNC:TARDBP)) + + + + + + + pubmed:29228318 + + complex(p(HGNC:PPP2CA), p(HGNC:PPP2CB)) decreases deg(p(HGNC:PPP2CB)) + + + + + + + pubmed:29228318 + + complex(p(HGNC:PPP2CA), p(HGNC:PPP2CB)) increases complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2CB)) + + + + + + + pubmed:29228318 + + complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2CB)) decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:29228318 + + complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2CB)) decreases a(CONSO:"paired helical filaments") + + + + + + + pubmed:29228318 + + complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2CB)) decreases a(MESH:Axons) + + + + + + + pubmed:29228318 + + complex(p(HGNC:MAPT), p(HGNC:PPP2CA), p(HGNC:PPP2CB)) decreases bp(GO:"cell death") + + + + + + + pubmed:29421605 + + p(RGD:Ptpn1) positiveCorrelation bp(GO:aging) + + + + + + + pubmed:29421605 + + p(RGD:Irs1, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation bp(GO:aging) + + + + + + + + + pubmed:29421605 + + p(RGD:Akt1, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation bp(GO:aging) + + + + + + + + + pubmed:29421605 + + p(RGD:Mtor, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation bp(GO:aging) + + + + + + + + + pubmed:29421605 + + p(RGD:Ntrk2, pmod(go:0006468 ! "protein phosphorylation")) negativeCorrelation bp(GO:aging) + + + + + + + pubmed:29062069 + + p(HGNC:MID1) decreases act(p(HGNC:PPP2CA)) + + + + + + + pubmed:29062069 + + p(HGNC:MID1) positiveCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:28422052 + + a(CHEBI:"folic acid") decreases p(MGI:Mapt, pmod(go:0006468 ! "protein phosphorylation", Ser, 396)) + + + + + + + pubmed:28422052 + + a(CHEBI:"folic acid") increases r(MGI:Dnmt1) + + + + + + + pubmed:28422052 + + a(CHEBI:"folic acid") increases p(FPLX:PPP2, pmod(go:0006479 ! "protein methylation")) + + + + + + + pubmed:25143394 + + p(MGI:Ppp1ca) negativeCorrelation p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:25143394 + + p(MGI:Ppp1cb) negativeCorrelation p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:23134599 + + a(CHEBI:"lead diacetate") decreases p(RGD:Ppp2ca) + + + + + + + pubmed:23134599 + + a(CHEBI:"lead diacetate") increases p(RGD:Ppp1ca) + + + + + + + pubmed:23134599 + + a(CHEBI:"lead diacetate") increases p(RGD:Ppp5c) + + + + + + + pubmed:23134599 + + a(CHEBI:"lead diacetate") increases p(MGI:Mapt, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:21489990 + + p(RGD:Egr1) increases act(p(RGD:Cdk5)) + + + + + + + pubmed:21489990 + + p(RGD:Egr1) increases p(FPLX:PPP1, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:21489990 + + p(FPLX:PPP1, pmod(go:0006468 ! "protein phosphorylation")) decreases act(p(FPLX:PPP1)) + + + + + + + pubmed:19623258 + + act(complex(GO:"NMDA selective glutamate receptor complex")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 199)) + + + + + + + pubmed:19623258 + + act(complex(GO:"NMDA selective glutamate receptor complex")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Ser, 202)) + + + + + + + pubmed:19623258 + + act(complex(GO:"NMDA selective glutamate receptor complex")) increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) + + + + + + + pubmed:25001178 + + p(HGNC:DUSP6) directlyDecreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:25001178 + + p(HGNC:DUSP6) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:25001178 + + p(HGNC:DUSP6) decreases p(FPLX:ERK) + + + + + + + pubmed:25001178 + + p(HGNC:BCL2L2) decreases p(HGNC:MAPT, pmod(CONSO:hyperphosphorylation)) + + + + + + + + + pubmed:24964035 + + p(FPLX:SMAD) decreases p(HGNC:PIN1) + + + + + + + pubmed:24964035 + + p(FPLX:SMAD) negativeCorrelation path(MESH:"Alzheimer Disease") + + + + + + + pubmed:22926167 + + p(HGNC:PIN1, pmod(go:0006468 ! "protein phosphorylation", Ser, 16)) decreases p(HGNC:PIN1) + + + + + + + pubmed:22926167 + + p(HGNC:PIN1, pmod(go:0006468 ! "protein phosphorylation", Ser, 16)) decreases p(HGNC:PIN1, loc(MESH:"Cell Nucleus")) + + + + + + + pubmed:22926167 + + p(HGNC:PIN1, pmod(go:0006468 ! "protein phosphorylation", Ser, 65)) decreases p(HGNC:PIN1) + + + + + + + pubmed:22926167 + + p(HGNC:PIN1, pmod(go:0006468 ! "protein phosphorylation", Ser, 65)) causesNoChange p(HGNC:PIN1, loc(MESH:"Cell Nucleus")) + + + + + + + pubmed:22926167 + + p(HGNC:PIN1, pmod(go:0006468 ! "protein phosphorylation", Ser, 65)) decreases p(HGNC:PIN1, pmod(go:0016567 ! "protein ubiquitination")) + + + + + + + pubmed:22926167 + + p(HGNC:PIN1, pmod(go:0006473 ! "protein acetylation", Lys, 46)) decreases p(HGNC:PIN1) + + + + + + + pubmed:22926167 + + complex(p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)), p(HGNC:PIN1)) decreases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation", Thr, 231)) + + + + + + + pubmed:22926167 + + p(HGNC:PIN1, pmod(go:0016567 ! "protein ubiquitination")) increases deg(p(HGNC:PIN1)) + + + + + + + + + pubmed:18305152 + + complex(GO:"exon-exon junction complex") increases bp(GO:"RNA splicing") + + + + + + + pubmed:27181519 + + bp(GO:"RNA splicing") association p(HGNC:FUS) + + + + + + + pubmed:27181519 + + bp(GO:"RNA splicing") association p(HGNC:TARDBP) + + + + + + + + + pubmed:18305152 + + path(OMIT:0026893) isA path(EFO:"neurodegenerative disease") + + + + + + + pubmed:23384725 + + path(OMIT:0026893) association p(HGNC:TARDBP) + + + + + + + pubmed:28669544 + + path(OMIT:0026893) increases p(HGNC:TARDBP, pmod(CONSO:"protein aggregation"), pmod(go:0016567 ! "protein ubiquitination"), loc(MESH:"Inclusion Bodies")) + + + + + + + pubmed:28669544 + + path(OMIT:0026893) negativeCorrelation a(MESH:"Frontal Lobe") + + + + + + + pubmed:28669544 + + path(EFO:"neurodegenerative disease") increases path(HP:"CNS demyelination") + + + + + + + pubmed:18305152 + + path(EFO:"amyotrophic lateral sclerosis") isA path(EFO:"neurodegenerative disease") + + + + + + + pubmed:18305152 + + act(p(HGNC:RB1)) association p(HGNC:CDK6) + + + + + + + pubmed:18305152 + + act(p(HGNC:RB1)) association p(HGNC:NAP1L1) + + + + + + + pubmed:18305152 + + p(HGNC:RB1) regulates p(HGNC:NAP1L1) + + + + + + + pubmed:18305152 + + act(p(HGNC:RB1)) association p(HGNC:CDK2) + + + + + + + pubmed:18305152 + + act(p(HGNC:RB1)) association p(HGNC:CKS1B) + + + + + + + pubmed:18305152 + + act(p(HGNC:RB1)) association p(HGNC:CCNG1) + + + + + + + pubmed:18305152 + + act(p(HGNC:RB1)) association p(HGNC:PLK1) + + + + + + + pubmed:18305152 + + act(p(HGNC:RB1)) association p(HGNC:CCNB1) + + + + + + + pubmed:18305152 + + act(p(HGNC:RB1)) association p(HGNC:EID1) + + + + + + + pubmed:18305152 + + act(p(HGNC:RB1)) association p(HGNC:TOP1) + + + + + + + pubmed:18305152 + + act(p(HGNC:RB1)) association p(HGNC:POLD4) + + + + + + + pubmed:18305152 + + act(p(HGNC:RB1)) association p(HGNC:RRM2) + + + + + + + pubmed:18305152 + + act(p(HGNC:RB1)) association p(HGNC:RBBP4) + + + + + + + pubmed:18305152 + + act(p(HGNC:RB1)) association p(HGNC:UBE2C) + + + + + + + pubmed:18305152 + + act(p(HGNC:RB1)) association p(HGNC:SKP2) + + + + + + + pubmed:18305152 + + act(p(HGNC:RB1)) association p(HGNC:HDAC1) + + + + + + + pubmed:18305152 + + act(p(HGNC:RB1)) association p(HGNC:E2F8) + + + + + + + pubmed:18305152 + + p(HGNC:RB1) regulates p(HGNC:E2F8) + + + + + + + pubmed:18305152 + + p(HGNC:RB1) regulates bp(GO:"cell cycle") + + + + + + + pubmed:18305152 + + p(HGNC:RB1) regulates bp(GO:"cell differentiation") + + + + + + + pubmed:18305152 + + p(HGNC:RB1) regulates bp(GO:"chromosome organization") + + + + + + + + + + + + + + + + + + + + + + + + + pubmed:18305152 + + p(HGNC:NAP1L1) association act(p(HGNC:RB1)) + + + + + + + pubmed:18305152 + + p(HGNC:CKS1B) association act(p(HGNC:RB1)) + + + + + + + pubmed:18305152 + + p(HGNC:CCNG1) association act(p(HGNC:RB1)) + + + + + + + pubmed:18305152 + + p(HGNC:PLK1) association act(p(HGNC:RB1)) + + + + + + + pubmed:18305152 + + p(HGNC:CCNB1) association act(p(HGNC:RB1)) + + + + + + + pubmed:18305152 + + p(HGNC:CCNB1) regulates bp(GO:"cell cycle") + + + + + + + pubmed:18305152 + + p(HGNC:EID1) association act(p(HGNC:RB1)) + + + + + + + + + + + pubmed:18305152 + + p(HGNC:TOP1) association act(p(HGNC:RB1)) + + + + + + + pubmed:18305152 + + p(HGNC:POLD4) association act(p(HGNC:RB1)) + + + + + + + pubmed:18305152 + + p(HGNC:POLD4) regulates bp(GO:"cell cycle") + + + + + + + pubmed:18305152 + + p(HGNC:RRM2) association act(p(HGNC:RB1)) + + + + + + + pubmed:18305152 + + p(HGNC:RBBP4) association act(p(HGNC:RB1)) + + + + + + + + + + + pubmed:18305152 + + p(HGNC:UBE2C) association act(p(HGNC:RB1)) + + + + + + + pubmed:18305152 + + p(HGNC:UBE2C) regulates bp(GO:"cell cycle") + + + + + + + pubmed:18305152 + + p(HGNC:SKP2) association act(p(HGNC:RB1)) + + + + + + + pubmed:18305152 + + p(HGNC:SKP2) regulates bp(GO:"cell cycle") + + + + + + + pubmed:18305152 + + p(HGNC:E2F8) association act(p(HGNC:RB1)) + + + + + + + pubmed:18305152 + + p(HGNCGENEFAMILY:"Cyclin dependent kinases") increases p(HGNC:RB1, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:18305152 + + p(HGNC:RB1, pmod(go:0006468 ! "protein phosphorylation")) decreases act(p(HGNC:RB1)) + + + + + + + pubmed:18305152 + + p(HGNC:RB1, pmod(go:0006468 ! "protein phosphorylation")) increases act(p(MESH:"Transcription Factors")) + + + + + + + pubmed:18305152 + + p(HGNC:RB1, pmod(go:0006468 ! "protein phosphorylation")) increases bp(GO:"cell cycle G1/S phase transition") + + + + + + + pubmed:18305152 + + bp(GO:"cell cycle G1/S phase transition") negativeCorrelation p(HGNC:TARDBP) + + + + + + + pubmed:18305152 + + composite(p(HGNC:HDAC1), p(HGNC:RB1)) increases complex(p(HGNC:HDAC1), p(HGNC:RB1)) + + + + + + + pubmed:18305152 + + composite(p(HGNC:RB1), p(HGNC:RBBP4)) increases complex(p(HGNC:RB1), p(HGNC:RBBP4)) + + + + + + + pubmed:18305152 + + composite(p(HGNC:EID1), p(HGNC:RB1)) increases complex(p(HGNC:EID1), p(HGNC:RB1)) + + + + + + + pubmed:18305152 + + composite(p(HGNC:CDK4), p(HGNC:CDK6)) increases bp(GO:"regulation of G0 to G1 transition") + + + + + + + pubmed:18305152 + + composite(p(HGNC:CDK6), p(HGNC:RB1)) increases complex(p(HGNC:CDK6), p(HGNC:RB1)) + + + + + + + pubmed:18305152 + + composite(p(HGNC:CDK6), p(HGNC:RBL2)) increases complex(p(HGNC:CDK6), p(HGNC:RBL2)) + + + + + + + + + + + + + pubmed:18305152 + + composite(p(HGNC:CDK6), p(NCBIGENE:3005)) increases complex(p(HGNC:CDK6), p(NCBIGENE:3005)) + + + + + + + + + + + pubmed:18305152 + + composite(p(HGNC:BCL2), p(HGNC:CDK6)) increases complex(p(HGNC:BCL2), p(HGNC:CDK6)) + + + + + + + pubmed:18305152 + + bp(GO:"G0 to G1 transition") positiveCorrelation p(HGNC:TARDBP) + + + + + + + pubmed:18305152 + + bp(GO:"cell cycle G2/M phase transition") negativeCorrelation p(HGNC:TARDBP) + + + + + + + pubmed:18305152 + + path(MESH:"Cell Nucleus Shape") negativeCorrelation p(HGNC:TARDBP) + + + + + + + pubmed:18305152 + + bp(GO:"meiotic DNA double-strand break formation") increases p(NCBIGENE:3014, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + + + pubmed:18305152 + + p(HGNC:PARP1, frag("?")) increases bp(GO:"induction of programmed cell death") + + + + + + + + + pubmed:18305152 + + path(NCIT:C17768) negativeCorrelation p(HGNC:TARDBP) + + + + + + + pubmed:18305152 + + path(NCIT:C91663) negativeCorrelation p(HGNC:TARDBP) + + + + + + + pubmed:18305152 + + path(NCIT:C91663) regulates path(NCIT:C17768) + + + + + + + pubmed:18305152 + + path(NCIT:C91663) regulates bp(GO:"programmed cell death") + + + + + + + pubmed:27181519 + + bp(GO:"RNA processing") association complex(GO:"ribonucleoprotein granule") + + + + + + + pubmed:23384725 + + bp(NCIT:C19375) association p(HGNC:TARDBP) + + + + + + + pubmed:23384725 + + composite(a(MESH:"Inclusion Bodies"), p(HGNC:TARDBP)) association path(DOID:"Alzheimer's disease") + + + + + + + pubmed:23384725 + + composite(a(MESH:"Inclusion Bodies"), p(HGNC:TARDBP)) association path(DOID:"Parkinson's disease") + + + + + + + pubmed:23384725 + + composite(a(MESH:"Inclusion Bodies"), p(HGNC:TARDBP)) association path(DOID:"Huntington's disease") + + + + + + + pubmed:23384725 + + p(HGNC:TARDBP, frag("1_105")) association p(CONSO:"TDP-43 oligomers") + + + + + + + pubmed:23384725 + + p(CONSO:"TDP-43 oligomers") association p(HGNC:TARDBP, frag("1_105")) + + + + + + + pubmed:23384725 + + act(p(HGNC:TARDBP, frag("101_191")), ma(GO:"nucleic acid binding")) association p(HGNC:TARDBP, frag("101_191")) + + + + + + + pubmed:23384725 + + p(HGNC:TARDBP, frag("101_191")) association act(p(HGNC:TARDBP, frag("101_191")), ma(GO:"nucleic acid binding")) + + + + + + + + + + + + + + + pubmed:23384725 + + act(p(HGNC:TARDBP, frag("101_191")), ma(GO:"nucleic acid binding")) negativeCorrelation p(HGNC:TARDBP, frag("101_191"), pmod(GO:"protein oxidation", Cys, 173)) + + + + + + + pubmed:23384725 + + act(p(HGNC:TARDBP, frag("101_191")), ma(GO:"nucleic acid binding")) negativeCorrelation p(HGNC:TARDBP, frag("101_191"), pmod(GO:"protein oxidation", Cys, 175)) + + + + + + + pubmed:23384725 + + act(p(HGNC:TARDBP, frag("192_265")), ma(GO:"nucleic acid binding")) association p(HGNC:TARDBP, frag("192_265")) + + + + + + + pubmed:23384725 + + p(HGNC:TARDBP, frag("192_265")) association act(p(HGNC:TARDBP, frag("192_265")), ma(GO:"nucleic acid binding")) + + + + + + + + + pubmed:23384725 + + p(HGNC:TARDBP, frag("266_414")) association bp(NCIT:C18469) + + + + + + + pubmed:23384725 + + bp(NCIT:C18469) association p(HGNC:TARDBP, frag("266_414")) + + + + + + + pubmed:23384725 + + p(HGNC:TARDBP, pmod(GO:"protein oxidation")) decreases bp(GO:"RNA splicing") + + + + + + + pubmed:23384725 + + composite(a(CHEBI:"1,4-dithiothreitol"), p(HGNC:TARDBP, frag("101_191"))) directlyDecreases p(CONSO:"TDP-43 aggregates") + + + + + + + + + pubmed:23384725 + + composite(a(CHEBI:"hydrogen peroxide"), p(HGNC:TARDBP, frag("101_191"))) decreases p(CONSO:"TDP-43 aggregates") + + + + + + + pubmed:23384725 + + a(MESH:Oxidants) causesNoChange p(CONSO:"TDP-43 aggregates") + + + + + + + pubmed:23384725 + + composite(p(HGNC:TARDBP, frag("101_191")), p(HGNC:TARDBP, frag("192_265"))) directlyIncreases p(CONSO:"TDP-43 aggregates") + + + + + + + pubmed:23384725 + + p(HGNC:TARDBP, frag("101_191"), pmod(GO:"protein oxidation", Cys, 173)) association p(CONSO:"TDP-43 aggregates") + + + + + + + pubmed:23384725 + + p(HGNC:TARDBP, frag("101_191"), pmod(GO:"protein oxidation", Cys, 173)) negativeCorrelation act(p(HGNC:TARDBP, frag("101_191")), ma(GO:"nucleic acid binding")) + + + + + + + pubmed:23384725 + + p(HGNC:TARDBP, frag("101_191"), pmod(GO:"protein oxidation", Cys, 173)) negativeCorrelation path(MESH:"Protein Conformation") + + + + + + + pubmed:23384725 + + p(HGNC:TARDBP, frag("101_191"), pmod(GO:"protein oxidation", Cys, 175)) association p(CONSO:"TDP-43 aggregates") + + + + + + + pubmed:23384725 + + p(HGNC:TARDBP, frag("101_191"), pmod(GO:"protein oxidation", Cys, 175)) negativeCorrelation act(p(HGNC:TARDBP, frag("101_191")), ma(GO:"nucleic acid binding")) + + + + + + + pubmed:23384725 + + p(HGNC:TARDBP, frag("101_191"), pmod(GO:"protein oxidation", Cys, 175)) association path(MESH:"Protein Conformation") + + + + + + + pubmed:23384725 + + composite(p(HGNC:TARDBP, frag("101_191")), p(HGNC:TARDBP, frag("101_191"))) increases p(CONSO:"TDP-43 aggregates") + + + + + + + pubmed:27181519 + + path(MESH:"Motor Neuron Disease") negativeCorrelation bp(GO:autophagy) + + + + + + + pubmed:27181519 + + path(MESH:"Motor Neuron Disease") negativeCorrelation act(p(HGNC:TARDBP)) + + + + + + + pubmed:30837838 + + path(MESH:"Motor Neuron Disease") association p(HGNC:TARDBP) + + + + + + + pubmed:27181519 + + bp(GO:"muscle atrophy") positiveCorrelation bp(GO:"motor neuron apoptotic process") + + + + + + + pubmed:27181519 + + bp(GO:"muscle atrophy") positiveCorrelation path(DOID:"amyotrophic lateral sclerosis") + + + + + + + pubmed:27181519 + + act(a(MESH:"Respiratory Muscles")) decreases path(MESH:Death) + + + + + + + + + pubmed:27181519 + + complex(GO:"cytoplasmic stress granule") isA complex(GO:"ribonucleoprotein granule") + + + + + + + pubmed:27181519 + + complex(GO:"cytoplasmic stress granule") regulates a(MESH:"RNA, Messenger") + + + + + + + pubmed:27181519 + + complex(GO:"cytoplasmic stress granule") negativeCorrelation bp(GO:translation) + + + + + + + pubmed:27181519 + + complex(GO:"cytoplasmic stress granule") negativeCorrelation act(complex(GO:"proteasome complex")) + + + + + + + pubmed:27181519 + + complex(GO:"cytoplasmic stress granule") decreases bp(MESH:"Unfolded Protein Response") + + + + + + + pubmed:27181519 + + complex(GO:"cytoplasmic stress granule", loc(MESH:"Motor Neurons")) positiveCorrelation path(DOID:"amyotrophic lateral sclerosis") + + + + + + + pubmed:27181519 + + complex(GO:"cytoplasmic stress granule") association p(HGNC:FUS, loc(GO:cytosol)) + + + + + + + pubmed:27181519 + + complex(GO:"cytoplasmic stress granule") association p(HGNC:TARDBP, loc(GO:cytosol)) + + + + + + + pubmed:30837838 + + complex(GO:"cytoplasmic stress granule") association p(HGNC:TARDBP) + + + + + + + pubmed:27181519 + + complex(GO:"cytoplasmic stress granule") association p(INTERPRO:"Prion/Doppel protein, beta-ribbon domain") + + + + + + + pubmed:27181519 + + complex(GO:"cytoplasmic stress granule") positiveCorrelation g(HGNC:C9orf72) + + + + + + + pubmed:27181519 + + complex(GO:"cytoplasmic stress granule", loc(GO:autophagosome)) increases bp(GO:"stress granule disassembly") + + + + + + + pubmed:27181519 + + complex(GO:"cytoplasmic stress granule") association p(HGNC:G3BP1) + + + + + + + pubmed:27181519 + + bp(GO:"RNA catabolic process") association complex(GO:P-body) + + + + + + + pubmed:27181519 + + a(MESH:Viruses) increases complex(GO:"cytoplasmic stress granule") + + + + + + + pubmed:24561250 + + a(MESH:Viruses) increases act(complex(GO:"inflammasome complex")) + + + + + + + pubmed:27181519 + + complex(a(GO:"cytoplasmic stress granule"), a(MESH:"RNA, Messenger")) decreases bp(GO:translation) + + + + + + + + + + + pubmed:27181519 + + p(HGNC:TIA1) increases bp(GO:"stress granule assembly") + + + + + + + pubmed:27181519 + + a(CHEBI:"autophagy inhibitor") decreases deg(complex(GO:"cytoplasmic stress granule")) + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, pmod(GO:"protein complex oligomerization")) increases act(p(HGNC:TARDBP), ma(GO:"RNA binding")) + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, pmod(GO:"protein complex oligomerization")) increases p(MESH:"RNA Splicing Factors") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, pmod(GO:"protein complex oligomerization")) increases path(MESH:"Cytotoxicity, Immunologic") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, pmod(GO:"protein complex oligomerization")) biomarkerFor path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:28669544 + + p(HGNC:TARDBP, pmod(CONSO:"protein aggregation"), loc(GO:cytosol)) directlyDecreases p(HGNC:TARDBP, loc(GO:nucleus)) + + + + + + + pubmed:28669544 + + p(HGNC:TARDBP, pmod(CONSO:"protein aggregation"), loc(GO:cytosol)) directlyIncreases act(p(HGNC:TARDBP)) + + + + + + + pubmed:28669544 + + p(HGNC:TARDBP, pmod(CONSO:"protein aggregation"), loc(GO:cytosol)) directlyIncreases bp(GO:"cell death") + + + + + + + pubmed:27181519 + + p(MESH:"Autophagy-Related Proteins") decreases path(MESH:"TDP-43 Proteinopathies") + + + + + + + pubmed:27181519 + + p(HGNC:FUS, pmod(go:0006479 ! "protein methylation")) increases p(HGNC:FUS, loc(GO:cytoplasm)) + + + + + + + pubmed:27181519 + + p(HGNC:FUS, pmod(go:0006468 ! "protein phosphorylation")) increases p(HGNC:FUS, loc(GO:cytoplasm)) + + + + + + + pubmed:27181519 + + p(INTERPRO:"Prion/Doppel protein, beta-ribbon domain") association complex(GO:"cytoplasmic stress granule") + + + + + + + pubmed:27181519 + + p(HGNC:MATR3) association path(DOID:"amyotrophic lateral sclerosis") + + + + + + + pubmed:30837838 + + p(HGNC:MATR3) association path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:27181519 + + p(HGNC:HNRNPA2B1) association path(DOID:"amyotrophic lateral sclerosis") + + + + + + + pubmed:27181519 + + p(HGNC:HNRNPA1) association path(DOID:"amyotrophic lateral sclerosis") + + + + + + + pubmed:27181519 + + g(HGNC:C9orf72, var("?")) association path(DOID:"amyotrophic lateral sclerosis") + + + + + + + + + pubmed:27181519 + + g(HGNC:C9orf72) association p(HGNC:RAB1A) + + + + + + + pubmed:27181519 + + g(HGNC:C9orf72) association p(HGNC:RAB1B) + + + + + + + pubmed:27181519 + + g(HGNC:C9orf72) association p(HGNC:RAB5A) + + + + + + + pubmed:27181519 + + g(HGNC:C9orf72) association p(HGNC:RAB7A) + + + + + + + pubmed:27181519 + + g(HGNC:C9orf72) association p(HGNC:RAB11A) + + + + + + + pubmed:27181519 + + g(HGNC:C9orf72) association p(HGNC:RAB11B) + + + + + + + pubmed:27181519 + + g(HGNC:C9orf72) increases act(a(GO:autophagosome)) + + + + + + + pubmed:27181519 + + g(HGNC:C9orf72) positiveCorrelation act(p(HGNC:NTRK2)) + + + + + + + pubmed:27181519 + + g(HGNC:C9orf72) positiveCorrelation act(p(HGNC:MAP1LC3A)) + + + + + + + pubmed:27181519 + + g(HGNC:C9orf72) positiveCorrelation complex(GO:"cytoplasmic stress granule") + + + + + + + pubmed:27181519 + + p(HGNC:RAB1B) association g(HGNC:C9orf72) + + + + + + + pubmed:27181519 + + p(HGNC:RAB11B) association g(HGNC:C9orf72) + + + + + + + pubmed:27181519 + + complex(p(HGNC:MAP1LC3A), p(HGNC:OPTN)) association bp(GO:autophagy) + + + + + + + pubmed:27181519 + + complex(p(HGNC:MAP1LC3A), p(HGNC:OPTN)) increases bp(GO:mitophagy) + + + + + + + pubmed:27181519 + + p(HGNC:OPTN, var("p.Glu478Gly")) association path(DOID:"amyotrophic lateral sclerosis") + + + + + + + + + pubmed:27181519 + + p(HGNC:OPTN, var("p.Glu478Gly")) increases complex(p(HGNC:OPTN), p(HGNC:OPTN, var("p.Glu478Gly"))) + + + + + + + pubmed:27181519 + + p(HGNC:OPTN, var("p.Glu478Gly")) decreases complex(a(MESH:Ubiquitin), p(HGNC:OPTN)) + + + + + + + pubmed:27181519 + + complex(p(HGNC:OPTN), p(HGNC:OPTN, var("p.Glu478Gly"))) decreases act(p(HGNC:OPTN)) + + + + + + + pubmed:27181519 + + complex(p(HGNC:OPTN), p(HGNC:OPTN, var("p.Glu478Gly"))) decreases complex(a(GO:autophagosome), p(HGNC:OPTN)) + + + + + + + pubmed:27181519 + + complex(p(HGNC:OPTN), p(HGNC:OPTN, var("p.Glu478Gly"))) decreases bp(GO:"autophagosome maturation") + + + + + + + pubmed:27181519 + + complex(p(HGNC:OPTN), p(HGNC:OPTN, var("p.Glu478Gly"))) decreases bp(GO:autophagy) + + + + + + + pubmed:27181519 + + complex(p(HGNC:OPTN), p(HGNC:OPTN, var("p.Glu478Gly"))) increases a(CONSO:"protein aggregates", loc(MESH:Cytosol)) + + + + + + + pubmed:27181519 + + p(HGNC:OPTN, pmod(go:0006468 ! "protein phosphorylation")) increases bp(GO:autophagy) + + + + + + + pubmed:27181519 + + complex(p(HGNC:OPTN), p(HGNC:TBK1)) association a(CONSO:"protein aggregates") + + + + + + + pubmed:27181519 + + p(HGNC:OPTN, pmod(go:0006468 ! "protein phosphorylation", Ser, 177)) regulates deg(a(CONSO:"protein aggregates")) + + + + + + + pubmed:27181519 + + p(HGNC:OPTN, pmod(go:0006468 ! "protein phosphorylation", Ser, 177)) regulates bp(GO:autophagy) + + + + + + + pubmed:27181519 + + path(DOID:"open-angle glaucoma") association p(HGNC:OPTN, var("p.Glu50Lys")) + + + + + + + pubmed:27181519 + + p(HGNC:OPTN, var("p.Glu50Lys")) association path(DOID:"open-angle glaucoma") + + + + + + + pubmed:27181519 + + p(HGNC:OPTN, var("p.Glu50Lys")) increases complex(p(HGNC:OPTN), p(HGNC:TBK1)) + + + + + + + pubmed:27181519 + + p(HGNC:UBQLN2, var("?")) association path(DOID:"amyotrophic lateral sclerosis") + + + + + + + pubmed:30837838 + + p(HGNC:UBQLN2, var("?")) association path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:30837838 + + p(HGNC:UBQLN2, var("?")) decreases path(MESH:Autophagy) + + + + + + + pubmed:30837838 + + p(HGNC:UBQLN2, var("?")) increases p(CONSO:"TDP-43 aggregates") + + + + + + + + + pubmed:27181519 + + p(HGNC:UBQLN2) increases p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination"), loc(GO:"proteasome complex")) + + + + + + + pubmed:27181519 + + p(HGNC:UBQLN2) increases deg(p(MESH:Proteins, pmod(go:0016567 ! "protein ubiquitination"))) + + + + + + + pubmed:27181519 + + p(HGNC:UBQLN2) increases bp(GO:"autophagosome assembly") + + + + + + + pubmed:30837838 + + p(HGNC:UBQLN2) association path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:27181519 + + complex(p(HGNC:HDAC6), p(HGNC:SQSTM1)) regulates act(p(HGNC:HDAC6), ma(GO:"protein deacetylation")) + + + + + + + pubmed:27181519 + + p(HGNC:SQSTM1, var("?")) association path(DOID:"amyotrophic lateral sclerosis") + + + + + + + pubmed:27181519 + + a(CHEBI:3-methyladenine) isA a(CHEBI:"autophagy inhibitor") + + + + + + + pubmed:27181519 + + a(CHEBI:3-methyladenine) decreases deg(p(HGNC:TARDBP)) + + + + + + + pubmed:30988501 + + bp(MESH:"Immunity, Innate") increases path(MESH:Pathology) + + + + + + + pubmed:30988501 + + bp(MESH:"Immunity, Innate") association path(MESH:Neuropsychiatry) + + + + + + + pubmed:28669544 + + a(MESH:Enzymes) increases deg(p(CONSO:"protein aggregates")) + + + + + + + pubmed:28669544 + + g(HGNC:TARDBP) increases p(HGNC:TARDBP) + + + + + + + pubmed:28669544 + + a(MESH:"Motor Cortex") negativeCorrelation path(DOID:"amyotrophic lateral sclerosis") + + + + + + + pubmed:28669544 + + composite(a(CHEBI:tamoxifen), a(MESH:Microglia)) directlyDecreases r(HGNC:TARDBP) + + + + + + + pubmed:28669544 + + composite(a(CHEBI:tamoxifen), a(MESH:Microglia)) causesNoChange r(HGNC:TARDBP, loc(MESH:"Cerebral Cortex")) + + + + + + + + + pubmed:28669544 + + composite(a(MESH:Microglia), p(HGNC:TARDBP)) increases path(MESH:"TDP-43 Proteinopathies") + + + + + + + pubmed:30837838 + + p(MESH:HIV-1) association p(HGNC:TARDBP) + + + + + + + pubmed:30837838 + + path(MESH:"Embryonic Development") association p(HGNC:TARDBP) + + + + + + + pubmed:30837838 + + path(MESH:"Muscular Atrophy, Spinal") association p(HGNC:TARDBP) + + + + + + + pubmed:30837838 + + p(HGNC:ATXN2) association path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:30837838 + + p(HGNC:PFN1) association path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:30837838 + + p(HGNC:UBQLN4) association path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:30837838 + + p(HGNC:NEK1) association path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:30837838 + + p(HGNC:CHCHD10) association path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:30837838 + + p(HGNC:CHCHD10) decreases p(CONSO:"TDP-43 aggregates", loc(GO:cytoplasm)) + + + + + + + pubmed:30837838 + + p(HGNC:CHCHD10) association a(MESH:Mitochondria) + + + + + + + pubmed:30837838 + + p(HGNC:SETX) association path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:30837838 + + p(HGNC:KIF5A) association path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + + + pubmed:30837838 + + complex(p(HGNC:TARDBP, frag("1_102")), p(HGNC:TARDBP, frag("1_102"))) increases path(MESH:"RNA Splicing") + + + + + + + pubmed:30837838 + + complex(p(HGNC:TARDBP, frag("1_102")), p(HGNC:TARDBP, frag("1_102"))) increases path(MESH:"RNA Splicing") + + + + + + + pubmed:30837838 + + complex(p(HGNC:TARDBP, frag("1_102")), p(HGNC:TARDBP, frag("1_102"))) association path(MESH:"Protein Aggregation, Pathological") + + + + + + + pubmed:30837838 + + complex(p(HGNC:TARDBP, frag("1_102")), p(HGNC:TARDBP, frag("1_102"))) increases path(MESH:Solubility) + + + + + + + pubmed:30837838 + + complex(p(HGNC:TARDBP, frag("1_102")), p(HGNC:TARDBP, frag("1_102"))) decreases a(MESH:"Inclusion Bodies") + + + + + + + pubmed:30837838 + + path(MESH:"RNA Splicing") association p(HGNC:TARDBP, var("p.Gln133Arg")) + + + + + + + pubmed:30837838 + + path(MESH:"RNA Splicing") association p(HGNC:TARDBP, var("p.Met337Val")) + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, frag("82_98"), var("?")) increases p(HGNC:TARDBP, frag("1_102"), loc(MESH:Cytoplasm)) + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, frag("82_98"), var("?")) increases p(CONSO:"TDP-43 aggregates") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, frag("82_98"), var("p.Ala90Val")) increases p(CONSO:"TDP-43 aggregates", loc(MESH:Cytoplasm)) + + + + + + + pubmed:30837838 + + bp(GO:"mRNA processing") association p(MESH:"RNA-Binding Proteins") + + + + + + + pubmed:30837838 + + path(MESH:"RNA Transport") association p(MESH:"RNA-Binding Proteins") + + + + + + + pubmed:30837838 + + path(MESH:"RNA Transport") association p(HGNC:TARDBP) + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, frag("104_176"), var("?")) negativeCorrelation bp(GO:"regulation of RNA binding") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, frag("104_176"), var("?")) causesNoChange path(MESH:"RNA Recognition Motif") + + + + + + + pubmed:30837838 + + bp(GO:"regulation of RNA binding") negativeCorrelation p(HGNC:TARDBP, frag("104_176"), var("?")) + + + + + + + pubmed:30837838 + + bp(GO:"regulation of RNA binding") negativeCorrelation p(HGNC:TARDBP, frag("192_262"), var("?")) + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, frag("192_262"), var("?")) negativeCorrelation bp(GO:"regulation of RNA binding") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, frag("192_262"), var("?")) causesNoChange path(MESH:"RNA Recognition Motif") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, frag("104_176"), var("p.Pro112His")) increases path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, frag("192_262"), var("p.Asp169Gly")) increases path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, frag("192_262")) increases complex(p(HGNC:TARDBP, frag("1_102")), p(HGNC:TARDBP, frag("1_102"))) + + + + + + + + + + + pubmed:30837838 + + composite(a(MESH:"DNA, Single-Stranded"), p(HGNC:TARDBP, frag("192_262"))) increases path(MESH:Solubility) + + + + + + + pubmed:30837838 + + composite(a(MESH:"DNA, Single-Stranded"), p(HGNC:TARDBP, frag("192_262"))) decreases p(CONSO:"TDP-43 aggregates") + + + + + + + + + pubmed:30837838 + + composite(a(MESH:"3' Untranslated Regions"), p(HGNC:TARDBP, frag("192_262"))) regulates path(MESH:Solubility) + + + + + + + pubmed:30837838 + + composite(a(MESH:"3' Untranslated Regions"), p(HGNC:TARDBP, frag("192_262"))) regulates path(MESH:Homeostasis) + + + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, frag("274_414")) association a(MESH:Cytotoxins) + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, frag("274_414")) association a(MESH:"Inclusion Bodies") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, frag("274_414")) increases path(MESH:"Protein Aggregation, Pathological") + + + + + + + + + pubmed:30837838 + + path(MESH:"Transcription, Genetic") association p(HGNC:TARDBP) + + + + + + + pubmed:30837838 + + bp(GO:"primary miRNA processing") association p(HGNC:TARDBP) + + + + + + + pubmed:30837838 + + p(MESH:"RNA, Long Noncoding") association p(HGNC:TARDBP) + + + + + + + pubmed:30837838 + + path(MESH:"Active Transport, Cell Nucleus") association p(HGNC:TARDBP) + + + + + + + pubmed:30837838 + + p(MESH:Neurons) negativeCorrelation p(HGNC:TARDBP) + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Gln133Arg")) association path(MESH:"RNA Splicing") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Met337Val")) association path(MESH:"RNA Splicing") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Met337Val")) causesNoChange path(MESH:"RNA Splicing") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Met337Val")) causesNoChange path(MESH:Translations) + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Met337Val")) increases path(MESH:"Protein Aggregation, Pathological") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Met337Val")) increases path(MESH:"Protein Aggregation, Pathological") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Met337Val")) increases path(MESH:"Cytotoxicity, Immunologic") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Met337Val")) negativeCorrelation bp(GO:"regulation of cytoplasmic transport") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Met337Val")) increases a(MESH:"Inclusion Bodies") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Met337Val")) increases path(MESH:"Protein Stability") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Met337Val")) increases path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Met337Val")) association path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Met337Val")) regulates bp(GO:"mRNA processing") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Met337Val")) negativeCorrelation bp(GO:translation) + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Met337Val")) increases p(CONSO:"TDP-43 aggregates") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Met337Val")) increases path(MESH:Viscosity) + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Met337Val")) decreases path(MESH:"Axonal Transport") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Met337Val")) decreases bp(GO:"mitochondrion localization") + + + + + + + pubmed:30837838 + + complex(p(HGNC:TARDBP), p(MESH:RNA)) increases p(MESH:Ribonucleoproteins) + + + + + + + + + pubmed:30837838 + + p(MESH:Ribonucleoproteins) increases path(MESH:"RNA Transport") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Ala315Thr")) causesNoChange path(MESH:"RNA Splicing") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Ala315Thr")) causesNoChange path(MESH:Translations) + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Ala315Thr")) increases p(MESH:Amyloid) + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Ala315Thr")) increases bp(GO:"neuron death") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Ala315Thr")) negativeCorrelation bp(GO:"regulation of cytoplasmic transport") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Ala315Thr")) increases path(MESH:"Protein Aggregation, Pathological") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Ala315Thr")) increases path(MESH:"Protein Aggregation, Pathological") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Ala315Thr")) increases path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Ala315Thr")) increases path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Ala315Thr")) regulates bp(GO:"mRNA processing") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Ala315Thr")) negativeCorrelation bp(GO:translation) + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Ala315Thr")) increases p(CONSO:"TDP-43 aggregates") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Ala315Thr")) increases a(CHEBI:"zinc ion") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Ala315Thr")) increases a(CHEBI:"manganese(2+)") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Ala315Thr")) increases a(CHEBI:"copper(2+)") + + + + + + + pubmed:30837838 + + complex(p(HGNC:RACK1), p(HGNC:TARDBP)) increases path(MESH:"Protein Biosynthesis") + + + + + + + pubmed:30837838 + + complex(p(HGNC:RACK1), p(HGNC:TARDBP)) decreases path(MESH:"Protein Biosynthesis") + + + + + + + + + pubmed:30837838 + + p(HGNC:RACK1) increases p(HGNC:TARDBP, loc(GO:"inclusion body")) + + + + + + + pubmed:30837838 + + a(CHEBI:"D-sorbitol-(13)C6") increases p(HGNC:TARDBP, var("p.Gly348Cys"), loc(GO:"cytoplasmic stress granule")) + + + + + + + pubmed:30837838 + + a(CHEBI:"D-sorbitol-(13)C6") increases bp(GO:"response to osmotic stress") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Gly348Cys")) increases path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Gly348Cys")) increases path(MESH:"Protein Aggregation, Pathological") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Gly348Cys")) regulates bp(GO:"mRNA processing") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Gly348Cys")) negativeCorrelation bp(GO:translation) + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Arg361Ser")) decreases complex(GO:"cytoplasmic stress granule") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Arg361Ser")) increases path(MESH:"Protein Aggregation, Pathological") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Arg361Ser")) increases path(MESH:"Cytotoxicity, Immunologic") + + + + + + + pubmed:30837838 + + complex(p(HGNC:DROSHA), p(HGNC:TARDBP), p(MESH:MicroRNAs)) increases bp(GO:"pre-miRNA processing") + + + + + + + + + pubmed:30837838 + + complex(p(HGNC:DICER1), p(HGNC:TARDBP)) increases bp(GO:"pre-miRNA processing") + + + + + + + pubmed:30837838 + + bp(GO:"regulation of cytoplasmic transport") negativeCorrelation p(HGNC:TARDBP, var("?")) + + + + + + + pubmed:30837838 + + bp(GO:"regulation of cytoplasmic transport") negativeCorrelation p(HGNC:TARDBP, var("p.Gly294Val")) + + + + + + + pubmed:30837838 + + bp(GO:"regulation of cytoplasmic transport") negativeCorrelation p(HGNC:TARDBP, var("p.Ala315Thr")) + + + + + + + pubmed:30837838 + + bp(GO:"regulation of cytoplasmic transport") negativeCorrelation p(HGNC:TARDBP, var("p.Met337Val")) + + + + + + + pubmed:30837838 + + bp(GO:"regulation of cytoplasmic transport") negativeCorrelation p(HGNC:TARDBP, var("Ala382Thr")) + + + + + + + pubmed:30837838 + + bp(GO:"regulation of cytoplasmic transport") negativeCorrelation p(HGNC:TARDBP, var("Gly376Asp")) + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Ala382Thr")) increases path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Ala382Thr")) increases path(MESH:"Protein Aggregation, Pathological") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Ala382Thr")) regulates bp(GO:"mRNA processing") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Ala382Thr")) negativeCorrelation bp(GO:translation) + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Gln331Lys")) increases path(MESH:"Protein Aggregation, Pathological") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Gln331Lys")) increases path(MESH:"Cytotoxicity, Immunologic") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Gln331Lys")) increases a(MESH:"Inclusion Bodies") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Gln331Lys")) increases path(MESH:"Protein Stability") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Gln331Lys")) association path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Gln331Lys")) increases p(CONSO:"TDP-43 aggregates") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Asp169Gly")) increases a(MESH:"Inclusion Bodies") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Asp169Gly")) increases path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Asp169Gly")) increases path(MESH:"Protein Aggregation, Pathological") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Asp169Gly")) regulates bp(GO:"mRNA processing") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Asp169Gly")) negativeCorrelation bp(GO:translation) + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Gly294Ala")) increases a(MESH:"Inclusion Bodies") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Gly294Val")) negativeCorrelation bp(GO:"regulation of cytoplasmic transport") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Gln343Arg")) increases path(MESH:"Protein Aggregation, Pathological") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Gln343Arg")) increases path(MESH:"Protein Aggregation, Pathological") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Gln343Arg")) increases path(MESH:"Protein Aggregation, Pathological") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Gln343Arg")) increases path(MESH:"Cytotoxicity, Immunologic") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Gln343Arg")) increases a(MESH:"Inclusion Bodies") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Gln343Arg")) increases path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Gln343Arg")) regulates bp(GO:"mRNA processing") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Gln343Arg")) negativeCorrelation bp(GO:translation) + + + + + + + pubmed:30837838 + + path(EFO:"familial amyotrophic lateral sclerosis") increases p(HGNC:TARDBP, var("p.Arg361Thr")) + + + + + + + pubmed:30837838 + + path(EFO:"familial amyotrophic lateral sclerosis") increases p(HGNC:TARDBP, var("p.Gly295Ser")) + + + + + + + pubmed:30837838 + + path(EFO:"familial amyotrophic lateral sclerosis") association p(HGNC:TARDBP, var("p.Gly295Ser"), loc(GO:mitochondrion)) + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Gly295Ser"), loc(GO:mitochondrion)) association path(EFO:"familial amyotrophic lateral sclerosis") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Gly295Ser"), loc(GO:mitochondrion)) increases bp(GO:"protein import into mitochondrial matrix") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Asn345Lys")) increases path(MESH:"Protein Aggregation, Pathological") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Asn345Lys")) increases path(MESH:"Cytotoxicity, Immunologic") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Asn390Asp")) increases path(MESH:"Protein Aggregation, Pathological") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Asn390Asp")) increases path(MESH:"Cytotoxicity, Immunologic") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Asn390Asp")) increases a(MESH:"Inclusion Bodies") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, frag("286_366"), var("?")) increases p(MESH:Amyloid) + + + + + + + pubmed:30837838 + + p(MESH:Amyloid) increases p(HGNC:TARDBP, frag("274_414"), pmod(go:0006468 ! "protein phosphorylation"), loc(GO:"inclusion body")) + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Ala315Glu"), loc(CONSO:"TDP-43 aggregates")) increases p(HGNC:APP, frag("1_40"), loc(CONSO:"amyloid-beta aggregates")) + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("Ala382Thr")) negativeCorrelation bp(GO:"regulation of cytoplasmic transport") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("Gly376Asp")) negativeCorrelation bp(GO:"regulation of cytoplasmic transport") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Gly298Ser")) increases path(MESH:"Protein Stability") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Gly298Ser")) increases path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Gly298Ser")) increases path(MESH:"Protein Aggregation, Pathological") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Gly298Ser")) regulates bp(GO:"mRNA processing") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Gly298Ser")) negativeCorrelation bp(GO:translation) + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Gly298Ser")) increases path(MESH:Viscosity) + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Gly298Ser")) decreases path(MESH:"Axonal Transport") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Asn352Ser")) increases path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Asn352Ser")) increases path(MESH:"Protein Aggregation, Pathological") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Asn352Ser")) regulates bp(GO:"mRNA processing") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Asn352Ser")) negativeCorrelation bp(GO:translation) + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Arg263Glu")) increases path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Arg263Glu")) increases path(MESH:"Protein Aggregation, Pathological") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Arg263Glu")) regulates bp(GO:"mRNA processing") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Arg263Glu")) negativeCorrelation bp(GO:translation) + + + + + + + pubmed:30837838 + + path(MESH:"Nuclear Localization Signals") regulates act(p(HGNC:TARDBP)) + + + + + + + pubmed:30837838 + + path(MESH:"Nuclear Export Signals") regulates act(p(HGNC:TARDBP)) + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, frag("82_98")) decreases p(CONSO:"TDP-43 aggregates", loc(GO:cytoplasm)) + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, frag("82_98")) increases p(HGNC:TARDBP) + + + + + + + + + pubmed:30837838 + + path(MESH:"Chromatin Assembly and Disassembly") association p(MESH:Histones) + + + + + + + pubmed:30837838 + + path(MESH:"Chromatin Assembly and Disassembly") positiveCorrelation p(HGNC:CHD1) + + + + + + + pubmed:30837838 + + path(MESH:"Chromatin Assembly and Disassembly") association path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, frag("239_250")) decreases p(CONSO:"TDP-43 aggregates", loc(GO:nucleus)) + + + + + + + pubmed:30837838 + + p(HGNC:CSNK2A2) increases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation", Ser, 379)) + + + + + + + pubmed:30837838 + + p(HGNC:CSNK2A2) increases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation", Ser, 403)) + + + + + + + pubmed:30837838 + + p(HGNC:CSNK2A2) increases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation", Ser, 404)) + + + + + + + pubmed:30837838 + + p(HGNC:CSNK2A2) increases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation", Ser, 409)) + + + + + + + pubmed:30837838 + + p(HGNC:CSNK2A2) increases p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation", Ser, 410)) + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination", Lys, 48)) increases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination", Lys, 63)) increases path(MESH:Autophagy) + + + + + + + pubmed:30837838 + + complex(p(HGNC:TARDBP), p(HGNC:UBE2E3)) increases p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination")) + + + + + + + pubmed:30837838 + + complex(p(HGNC:TARDBP), p(HGNC:UBE2E3)) increases p(CONSO:"TDP-43 aggregates") + + + + + + + + + pubmed:30837838 + + complex(p(HGNC:TARDBP), p(HGNC:USP8)) increases p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination")) + + + + + + + pubmed:30837838 + + complex(p(HGNC:TARDBP), p(HGNC:USP8)) increases p(CONSO:"TDP-43 aggregates") + + + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Lys293Asp")) increases p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination")) + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination", Lys, 48), var("?")) decreases p(CONSO:"TDP-43 aggregates") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination", Lys, 63), var("?")) decreases p(CONSO:"TDP-43 aggregates") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, pmod(go:0006473 ! "protein acetylation")) increases p(HGNC:TARDBP, pmod(CONSO:hyperphosphorylation)) + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, pmod(go:0006473 ! "protein acetylation")) negativeCorrelation act(p(HGNC:TARDBP), ma(GO:"regulation of RNA binding")) + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, pmod(go:0006473 ! "protein acetylation")) increases path(CONSO:"mitochondrial dysfunction") + + + + + + + pubmed:30837838 + + a(CHEBI:"arsenite ion") increases path(MESH:"Oxidative Stress") + + + + + + + pubmed:30837838 + + p(HGNC:TNKS) increases complex(a(CHEBI:"cyclic ADP-ribose"), p(HGNC:TARDBP, frag("82_98"))) + + + + + + + pubmed:30837838 + + complex(a(CHEBI:"cyclic ADP-ribose"), p(HGNC:TARDBP, frag("82_98"))) decreases p(CONSO:"TDP-43 aggregates") + + + + + + + + + + + pubmed:30837838 + + complex(a(CHEBI:"cyclic ADP-ribose"), p(HGNC:TARDBP)) increases complex(a(GO:"cytoplasmic stress granule"), p(HGNC:TARDBP)) + + + + + + + pubmed:30837838 + + a(CHEBI:cysteine) association path(MESH:Oxidation-Reduction) + + + + + + + pubmed:30837838 + + path(MESH:Oxidation-Reduction) association a(CHEBI:cysteine) + + + + + + + pubmed:30837838 + + path(MESH:Oxidation-Reduction) association path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:30837838 + + bp(GO:"peptidyl-cysteine oxidation") association path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:30837838 + + bp(GO:"peptidyl-cysteine oxidation") increases complex(p(HGNC:TARDBP), p(HGNC:TARDBP)) + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Gly358Cys")) increases path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Ser379Cys")) increases path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Gly295Cys")) increases path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Gly295Cys")) increases complex(p(HGNC:TARDBP, var("p.Gly295Cys")), p(HGNC:TARDBP, var("p.Gly295Cys"))) + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, frag("104_176")) association p(HGNC:TARDBP, pmod(MESH:"Protein Folding")) + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, pmod(MESH:"Protein Folding")) association p(HGNC:TARDBP, frag("104_176")) + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, frag("247_250")) increases p(CONSO:"TDP-43 aggregates") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, frag("247_250")) association p(HGNC:IAPP) + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, frag("312_316")) increases p(CONSO:"TDP-43 aggregates") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, frag("312_316")) association p(HGNC:IAPP) + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Gly335Asp")) increases path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Gly335Asp")) increases p(CONSO:"TDP-43 aggregates") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, frag("312_317"), var("p.Ala315Thr")) increases path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, frag("312_317"), var("p.Ala315Glu")) increases path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:30837838 + + bp(GO:"response to osmotic stress") increases p(HGNC:TARDBP, pmod(GO:"protein complex oligomerization")) + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Ala321Gly")) association path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("p.Ala321Gly")) increases p(CONSO:"TDP-43 aggregates") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, frag("1_102"), pmod(go:0006468 ! "protein phosphorylation", Ser, 48)) increases p(HGNC:TARDBP, frag("1_102"), pmod(MESH:Polymerization)) + + + + + + + pubmed:30837838 + + complex(p(HGNC:ATG7), p(HGNC:TARDBP)) regulates path(MESH:Autophagy) + + + + + + + pubmed:30837838 + + bp(GO:"vacuole fusion") association deg(p(HGNC:TARDBP)) + + + + + + + pubmed:30837838 + + bp(GO:"vacuole fusion") association path(MESH:"Cell Survival") + + + + + + + pubmed:30837838 + + path(MESH:"Endoplasmic Reticulum-Associated Degradation") association deg(p(HGNC:TARDBP)) + + + + + + + pubmed:30837838 + + path(MESH:"Endoplasmic Reticulum-Associated Degradation") association path(MESH:"Cell Survival") + + + + + + + pubmed:30837838 + + p(HGNCGENEFAMILY:ESCRT-0) decreases p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination"), loc(GO:"inclusion body")) + + + + + + + pubmed:30837838 + + bp(GO:"cytoplasm protein quality control by the ubiquitin-proteasome system") increases deg(p(HGNC:TARDBP)) + + + + + + + pubmed:30837838 + + path(MESH:Endocytosis) negativeCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:30837838 + + path(MESH:Endocytosis) decreases p(CONSO:"TDP-43 aggregates") + + + + + + + pubmed:30837838 + + path(MESH:Transportation) association bp(GO:"neuron fate commitment") + + + + + + + pubmed:30837838 + + path(MESH:Transportation) association path(MESH:"Nerve Degeneration") + + + + + + + pubmed:30837838 + + bp(GO:"neuron fate commitment") association path(MESH:Transportation) + + + + + + + pubmed:30837838 + + bp(GO:"neuron fate commitment") association path(MESH:"Mitochondrial Size") + + + + + + + pubmed:30837838 + + bp(GO:"neuron fate commitment") association a(CHEBI:"calcium(2+)") + + + + + + + pubmed:30837838 + + bp(GO:"neuron fate commitment") association path(MESH:"Cell Respiration") + + + + + + + pubmed:30837838 + + bp(GO:"neuron fate commitment") association bp(GO:"ATP biosynthetic process") + + + + + + + pubmed:30837838 + + path(MESH:"Mitochondrial Size") association bp(GO:"neuron fate commitment") + + + + + + + pubmed:30837838 + + path(MESH:"Mitochondrial Size") association path(MESH:"Nerve Degeneration") + + + + + + + pubmed:30837838 + + path(MESH:"Cell Respiration") association bp(GO:"neuron fate commitment") + + + + + + + pubmed:30837838 + + path(MESH:"Cell Respiration") association path(MESH:"Nerve Degeneration") + + + + + + + pubmed:30837838 + + a(CHEBI:"etacrynic acid") decreases a(CHEBI:glutathione) + + + + + + + pubmed:30837838 + + complex(a(CHEBI:4-hydroxynonenal), p(HGNC:TARDBP)) decreases deg(p(HGNC:TARDBP)) + + + + + + + pubmed:30837838 + + complex(a(CHEBI:4-hydroxynonenal), p(HGNC:TARDBP)) increases p(HGNC:TARDBP, loc(GO:cytoplasm)) + + + + + + + + + pubmed:30837838 + + p(HGNC:SOD1, pmod(MESH:"Protein Aggregates"), var("?")) increases p(CONSO:"TDP-43 aggregates") + + + + + + + pubmed:30837838 + + p(HGNC:SOD1, pmod(MESH:"Protein Aggregates"), var("?")) negativeCorrelation p(HGNC:TARDBP, loc(GO:cytoplasm)) + + + + + + + pubmed:30837838 + + complex(p(HGNC:SOD1, var("?")), p(HGNC:TARDBP, frag("274_414"))) increases a(MESH:"Toxic Actions") + + + + + + + pubmed:30837838 + + complex(p(HGNC:RMDN3), p(HGNC:VAPB)) decreases path(MESH:Autophagy) + + + + + + + + + pubmed:30837838 + + p(HGNC:SART3) decreases p(HGNC:DNM1L) + + + + + + + pubmed:30837838 + + p(HGNC:SART3) decreases p(HGNC:FIS1) + + + + + + + pubmed:30837838 + + bp(GO:"mitochondrion localization") increases path(MESH:"Cognitive Dysfunction") + + + + + + + pubmed:30837838 + + bp(GO:"mitochondrion localization") decreases path(MESH:"Recovery of Function") + + + + + + + pubmed:30837838 + + a(CHEBI:"zinc ion") increases a(MESH:"Inclusion Bodies") + + + + + + + pubmed:30837838 + + a(CHEBI:"zinc ion") increases path(MESH:"Protein Aggregation, Pathological") + + + + + + + pubmed:30837838 + + a(CHEBI:"lead atom") increases p(HGNC:TARDBP, loc(GO:"inclusion body")) + + + + + + + pubmed:30837838 + + a(CHEBI:"lead atom") decreases act(p(HGNC:TARDBP), ma(MESH:"RNA Splicing")) + + + + + + + pubmed:30837838 + + a(CHEBI:"mercury atom") increases p(HGNC:TARDBP, loc(GO:"inclusion body")) + + + + + + + pubmed:30837838 + + a(CHEBI:"tin atom") increases p(HGNC:TARDBP, loc(GO:"inclusion body")) + + + + + + + pubmed:30837838 + + a(PUBCHEM:6860) decreases act(p(HGNC:TARDBP), ma(MESH:"RNA Splicing")) + + + + + + + pubmed:30837838 + + p(MESH:"Heat-Shock Proteins") increases p(CONSO:"TDP-43 aggregates", loc(GO:nucleus)) + + + + + + + pubmed:30837838 + + p(HGNC:CHD1) increases p(MESH:"Heat-Shock Proteins") + + + + + + + pubmed:30837838 + + p(HGNC:CHD1) positiveCorrelation path(MESH:"Chromatin Assembly and Disassembly") + + + + + + + pubmed:30837838 + + p(HGNC:CHD2) decreases p(HGNC:TARDBP, loc(GO:cytoplasm)) + + + + + + + pubmed:30837838 + + p(HGNC:SS18) regulates path(MESH:"Cell Differentiation") + + + + + + + pubmed:30837838 + + p(HGNC:SS18) regulates bp(GO:"dendrite extension") + + + + + + + pubmed:30837838 + + p(HGNC:SS18) regulates path(MESH:"Synaptic Transmission") + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("Met337Val")) decreases p(CONSO:"Histone H3", pmod(go:0006468 ! "protein phosphorylation", Ser, 10), pmod(go:0006473 ! "protein acetylation", Lys, 14)) + + + + + + + pubmed:30837838 + + p(HGNC:TARDBP, var("Met337Val")) association path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:30837838 + + path(MESH:Sclerosis) association p(HGNC:TARDBP, pmod(go:0006468 ! "protein phosphorylation"), loc(GO:"inclusion body")) + + + + + + + pubmed:30837838 + + path(MESH:Sclerosis) association p(HGNC:TARDBP, pmod(go:0016567 ! "protein ubiquitination"), loc(GO:"inclusion body")) + + + + + + + pubmed:30837838 + + p(CHEBI:Riluzole) decreases p(HGNCGENEFAMILY:"Glutamate metabotropic receptors") + + + + + + + pubmed:30837838 + + p(CHEBI:Riluzole) regulates a(CHEBI:"D-glutamate(1-)") + + + + + + + pubmed:30837838 + + p(CHEBI:Riluzole) regulates bp(GO:"chemical synaptic transmission, postsynaptic") + + + + + + + pubmed:30837838 + + p(CHEBI:Riluzole) decreases p(MESH:"Voltage-Gated Sodium Channels") + + + + + + + pubmed:30837838 + + a(CHEBI:mexiletine) decreases p(MESH:"Voltage-Gated Sodium Channels") + + + + + + + pubmed:30837838 + + a(CHEBI:mexiletine) decreases path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:30837838 + + a(CHEBI:edaravone) isA a(MESH:Antioxidants) + + + + + + + pubmed:30837838 + + a(CHEBI:edaravone) decreases path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:30837838 + + a(CHEBI:edaravone) isA a(MESH:"Free Radical Scavengers") + + + + + + + pubmed:30837838 + + a(CHEBI:edaravone) decreases path(MESH:"Oxidative Stress") + + + + + + + pubmed:30837838 + + a(CHEBI:Riluzole) decreases path(MESH:"Amyotrophic Lateral Sclerosis") + + + + + + + pubmed:30837838 + + a(CHEBI:masitinib) decreases act(p(MESH:"Protein-Tyrosine Kinases")) + + + + + + + pubmed:30837838 + + a(CHEBI:masitinib) regulates path(MESH:"Cell Degranulation") + + + + + + + pubmed:30837838 + + a(CHEBI:masitinib) regulates path(MESH:"Cell Differentiation") + + + + + + + pubmed:30837838 + + a(CHEBI:masitinib) regulates path(MESH:"Cell Survival") + + + + + + + pubmed:30837838 + + a(CHEBI:masitinib) decreases path(MESH:"Neurogenic Inflammation") + + + + + + + pubmed:30837838 + + a(CHEBI:masitinib) decreases a(MESH:Cytokines) + + + + + + + pubmed:30837838 + + a(PUBCHEM:68476) negativeCorrelation act(p(HGNC:TARDBP), ma(GO:"nucleic acid binding")) + + + + + + + pubmed:30837838 + + a(PUBCHEM:68476) increases p(MESH:Caspases) + + + + + + + pubmed:30837838 + + a(PUBCHEM:9577280) decreases a(CHEBI:"copper(2+)") + + + + + + + pubmed:30837838 + + a(PUBCHEM:9577280) decreases complex(a(GO:"cytoplasmic stress granule"), p(HGNC:TARDBP)) + + + + + + + pubmed:30837838 + + a(PUBCHEM:9577280) decreases p(HGNC:TARDBP, frag("274_414"), pmod(MESH:"Protein Aggregates")) + + + + + + + pubmed:30837838 + + a(PUBCHEM:137275684) decreases a(CHEBI:"copper(2+)") + + + + + + + pubmed:30837838 + + a(PUBCHEM:137275684) decreases complex(a(GO:"cytoplasmic stress granule"), p(HGNC:TARDBP)) + + + + + + + pubmed:30837838 + + a(PUBCHEM:137275684) decreases p(HGNC:TARDBP, frag("274_414"), pmod(MESH:"Protein Aggregates")) + + + + + + + pubmed:30837838 + + complex(a(MESH:"Nuclear Localization Signals"), p(HGNC:KPNB1)) increases deg(p(CONSO:"TDP-43 aggregates")) + + + + + + + pubmed:30837838 + + complex(p(CONSO:"TDP-43 aggregates"), p(HGNCGENEFAMILY:"Heat shock 70kDa proteins")) increases deg(p(CONSO:"TDP-43 aggregates")) + + + + + + + pubmed:30837838 + + complex(p(CONSO:"TDP-43 aggregates"), p(HGNCGENEFAMILY:"Heat shock 70kDa proteins")) increases p(HGNC:TARDBP, pmod(MESH:"Protein Refolding")) + + + + + + + pubmed:26702100 + + p(HGNC:RPS6KB1, pmod(go:0006468 ! "protein phosphorylation", Thr, 389)) negativeCorrelation act(p(HGNCGENEFAMILY:"MTOR complex 1")) + + + + + + + pubmed:26702100 + + p(HGNC:RPTOR) regulates act(p(HGNC:MTOR)) + + + + + + + pubmed:26702100 + + p(HGNC:RPTOR) increases p(HGNC:MTOR, loc(GO:lysosome)) + + + + + + + pubmed:26702100 + + p(HGNC:RPTOR) increases p(HGNC:MTOR) + + + + + + + pubmed:26702100 + + p(HGNC:RPTOR) regulates p(HGNC:MTOR) + + + + + + + + + + + + + + + + + pubmed:26702100 + + p(HGNC:RPTOR) association p(HGNC:TARDBP) + + + + + + + pubmed:26702100 + + p(HGNC:RPTOR) increases tloc(p(HGNC:TFEB), fromLoc(GO:nucleus), toLoc(GO:cytoplasm)) + + + + + + + pubmed:26702100 + + p(HGNC:RRAGA) regulates act(p(HGNC:MTOR)) + + + + + + + pubmed:26702100 + + p(HGNC:RRAGA) increases p(HGNC:MTOR, loc(GO:lysosome)) + + + + + + + + + + + + + + + pubmed:26702100 + + p(HGNC:RRAGA) increases p(HGNC:TFEB, loc(GO:lysosome)) + + + + + + + pubmed:26702100 + + p(HGNC:RRAGA) association p(HGNC:TFEB, loc(GO:lysosome)) + + + + + + + + + + + pubmed:26702100 + + p(HGNC:LAMTOR1) increases p(HGNC:RRAGA, loc(GO:lysosome)) + + + + + + + pubmed:26702100 + + p(HGNC:LAMTOR1) increases p(HGNC:RRAGC, loc(GO:lysosome)) + + + + + + + + + + + pubmed:26702100 + + complex(a(GO:"Ragulator complex"), p(HGNC:RRAGA), p(HGNCGENEFAMILY:"MTOR complex 1")) increases complex(a(GO:lysosome), p(HGNC:RRAGA)) + + + + + + + + + pubmed:26702100 + + complex(a(GO:lysosome), p(HGNC:RRAGA)) increases a(CHEBI:"amino acid") + + + + + + + + + + + + + + + + + + + pubmed:26702100 + + p(HGNC:RRAGB) decreases p(HGNC:TFEB, loc(GO:nucleus)) + + + + + + + pubmed:26702100 + + p(HGNC:RRAGB) causesNoChange p(HGNC:TFEB, loc(GO:lysosome)) + + + + + + + pubmed:26702100 + + p(HGNC:RHEB) increases act(p(HGNC:MTOR)) + + + + + + + + + + + pubmed:26702100 + + p(HGNC:CD63) association a(GO:lysosome) + + + + + + + pubmed:26702100 + + p(HGNC:TFEB, var("p.Met1_Val30del")) decreases complex(a(GO:lysosome), p(HGNC:RRAGA), p(HGNC:TFEB)) + + + + + + + pubmed:26702100 + + p(HGNC:TFEB, var("p.Met1_Val30del")) decreases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation", Ser, 211)) + + + + + + + pubmed:26702100 + + p(HGNC:TFEB, var("p.Met1_Val30del")) increases p(HGNC:TFEB, loc(GO:nucleus)) + + + + + + + pubmed:26702100 + + complex(a(GO:lysosome), p(HGNC:RRAGA), p(HGNC:TFEB)) increases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation", Ser, 211)) + + + + + + + pubmed:26702100 + + p(HGNC:TFEB, var("p.Gln10Ala"), var("p.Lys11Ala")) decreases complex(a(GO:lysosome), p(HGNC:RRAGA), p(HGNC:TFEB)) + + + + + + + pubmed:26702100 + + p(HGNC:TFEB, var("p.Gln10Ala"), var("p.Lys11Ala")) decreases p(HGNC:TFEB, pmod(go:0006468 ! "protein phosphorylation", Ser, 211)) + + + + + + + pubmed:26702100 + + p(HGNC:TFEB, var("p.Gln10Ala"), var("p.Lys11Ala")) increases p(HGNC:TFEB, loc(GO:nucleus)) + + + + + + + pubmed:26702100 + + p(HGNC:ATG9B) association bp(GO:autophagy) + + + + + + + + + pubmed:28019679 + + bp(GO:"innate immune response") increases act(complex(GO:"NLRP3 inflammasome complex")) + + + + + + + pubmed:28019679 + + a(MESH:"Toll-Like Receptors") increases act(complex(GO:"NLRP3 inflammasome complex")) + + + + + + + pubmed:28019679 + + composite(a(CHEBI:amyloid-beta), p(HGNC:CTSB)) increases act(complex(GO:"NLRP3 inflammasome complex")) + + + + + + + pubmed:28019679 + + composite(a(CHEBI:amyloid-beta), p(HGNC:CD36)) increases act(complex(GO:"NLRP3 inflammasome complex")) + + + + + + + pubmed:28019679 + + complex(GO:"NLRP1 inflammasome complex") increases act(p(HGNC:CASP1)) + + + + + + + pubmed:23702978 + + complex(GO:"NLRP1 inflammasome complex") increases act(p(HGNC:CASP1)) + + + + + + + pubmed:28019679 + + act(complex(GO:"NLRP1 inflammasome complex")) increases act(p(HGNC:CASP6)) + + + + + + + pubmed:28019679 + + act(complex(GO:"NLRP1 inflammasome complex")) increases a(CHEBI:"amyloid-beta polypeptide 42") + + + + + + + pubmed:28019679 + + complex(GO:"NLRP1 inflammasome complex") increases bp(GO:pyroptosis) + + + + + + + pubmed:28019679 + + complex(GO:"NLRP1 inflammasome complex") increases path(CONSO:CONSO00027) + + + + + + + pubmed:23702978 + + complex(GO:"NLRP1 inflammasome complex") increases act(p(HGNC:CASP5)) + + + + + + + + + pubmed:24561250 + + complex(GO:"NLRP1 inflammasome complex") increases p(HGNC:IL1B) + + + + + + + pubmed:24561250 + + act(complex(GO:"NLRP1 inflammasome complex")) increases p(HGNC:IL1B) + + + + + + + pubmed:24561250 + + act(complex(GO:"NLRP1 inflammasome complex")) increases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:24561250 + + act(complex(GO:"NLRP1 inflammasome complex")) increases tloc(p(HGNC:IL18), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:23702978 + + complex(p(HGNC:CASP1), p(HGNC:CASP1)) increases act(p(HGNC:CASP1)) + + + + + + + pubmed:23702978 + + bp(GO:"cell activation") increases p(HGNC:IL18) + + + + + + + + + pubmed:23702978 + + p(HGNC:NLRP6) increases bp(GO:"negative regulation of innate immune response") + + + + + + + + + + + pubmed:23702978 + + p(HGNC:NLRP12) increases bp(GO:"dendritic cell migration") + + + + + + + pubmed:23702978 + + p(HGNC:NLRP12) increases bp(GO:"negative regulation of NIK/NF-kappaB signaling") + + + + + + + pubmed:23702978 + + complex(GO:"IPAF inflammasome complex") increases act(p(HGNC:CASP1)) + + + + + + + + + pubmed:24561250 + + complex(GO:"IPAF inflammasome complex") increases p(HGNC:IL1B) + + + + + + + pubmed:24561250 + + complex(GO:"IPAF inflammasome complex") increases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:24561250 + + act(complex(GO:"IPAF inflammasome complex")) increases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:24561250 + + complex(GO:"IPAF inflammasome complex") increases p(HGNC:IL1B) + + + + + + + pubmed:24561250 + + complex(GO:"IPAF inflammasome complex") association path(MESH:"Alzheimer Disease") + + + + + + + pubmed:23702978 + + composite(complex(GO:"NLRP1 inflammasome complex"), p(HGNC:PYCARD)) increases act(p(HGNC:CASP1)) + + + + + + + pubmed:23702978 + + composite(complex(GO:"IPAF inflammasome complex"), p(HGNC:PYCARD)) increases act(p(HGNC:CASP1)) + + + + + + + + + pubmed:23702978 + + act(p(HGNC:IFI16)) increases act(p(HGNC:TMEM173)) + + + + + + + + + pubmed:23702978 + + act(p(HGNC:DDX58)) increases act(p(HGNC:MAVS)) + + + + + + + pubmed:23702978 + + a(CHEBI:"RNA fragment") increases act(p(HGNC:DDX58)) + + + + + + + pubmed:27314526 + + a(CHEBI:"RNA fragment") increases act(complex(GO:"NLRP3 inflammasome complex")) + + + + + + + pubmed:23702978 + + act(p(HGNC:MAVS)) increases bp(GO:"response to type I interferon") + + + + + + + pubmed:23702978 + + a(CHEBI:"DNA polyanion") increases act(p(HGNC:IFI16)) + + + + + + + pubmed:23702978 + + act(p(HGNC:TMEM173)) increases bp(GO:"response to type I interferon") + + + + + + + pubmed:23702978 + + a(CHEBI:"muramyl dipeptide") increases act(p(HGNC:NLRP1)) + + + + + + + + + + + pubmed:23702978 + + complex(a(CHEBI:"muramyl dipeptide"), p(HGNC:NLRP1)) increases act(complex(GO:"inflammasome complex")) + + + + + + + pubmed:23702978 + + complex(p(HGNC:NLRP1), p(HGNC:NOD2)) increases act(complex(GO:"inflammasome complex")) + + + + + + + + + + + pubmed:23702978 + + act(p(HGNC:NAIP)) increases complex(GO:"IPAF inflammasome complex") + + + + + + + pubmed:24561250 + + p(HGNC:NAIP) increases act(complex(GO:"IPAF inflammasome complex")) + + + + + + + pubmed:23702978 + + p(HGNC:SCAF11) increases bp(GO:pyroptosis) + + + + + + + pubmed:23702978 + + act(p(HGNC:SCAF11)) increases bp(GO:pyroptosis) + + + + + + + + + pubmed:23702978 + + a(CHEBI:"LPS with O-antigen") increases bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") + + + + + + + pubmed:23702978 + + bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") regulates tloc(a(MESH:"Interferon Type I"), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:23702978 + + bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") increases p(HGNC:SCAF11) + + + + + + + pubmed:23702978 + + bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") increases act(p(HGNC:IFNAR1)) + + + + + + + pubmed:23702978 + + bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") increases act(p(HGNC:CASP8)) + + + + + + + pubmed:23702978 + + a(MESH:"Interferon Type I") decreases tloc(p(HGNC:IL1B), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:23702978 + + a(MESH:"Interferon Type I") decreases tloc(p(HGNC:IL18), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:23702978 + + p(HGNC:PRTN3) increases act(p(HGNC:IL1B)) + + + + + + + pubmed:23702978 + + act(p(HGNC:CLEC7A)) increases act(p(HGNC:SYK)) + + + + + + + pubmed:23702978 + + complex(p(HGNC:CASP8), p(HGNC:MALT1)) increases complex(p(HGNC:CASP8), p(HGNC:MALT1), p(HGNC:PYCARD)) + + + + + + + + + + + pubmed:23702978 + + complex(p(HGNC:CASP8), p(HGNC:MALT1), p(HGNC:PYCARD)) increases act(p(HGNC:IL1B)) + + + + + + + pubmed:23702978 + + complex(GO:ripoptosome) increases act(p(HGNC:CASP8)) + + + + + + + pubmed:23702978 + + complex(GO:ripoptosome) increases act(p(HGNC:RIPK3)) + + + + + + + + + + + pubmed:23702978 + + p(HGNC:XIAP) decreases complex(GO:ripoptosome) + + + + + + + + + pubmed:23702978 + + p(HGNC:BIRC3) decreases complex(GO:ripoptosome) + + + + + + + pubmed:23702978 + + act(p(HGNC:RIPK3)) increases act(p(HGNC:IL1B)) + + + + + + + pubmed:23702978 + + act(p(HGNC:RIPK3)) increases act(p(HGNC:CASP1)) + + + + + + + pubmed:23702978 + + act(p(HGNC:RIPK3)) increases act(p(HGNC:CASP8)) + + + + + + + pubmed:23702978 + + p(FPLX:TNFRSF) increases p(HGNC:NLRP3) + + + + + + + pubmed:23702978 + + p(HGNC:BRCC3) decreases p(HGNC:NLRP3, pmod(go:0016567 ! "protein ubiquitination")) + + + + + + + pubmed:23702978 + + p(FPLX:IFNB) increases p(HGNC:AIM2) + + + + + + + pubmed:23702978 + + act(p(HGNC:PRKCD), ma(go:0016301 ! "kinase activity")) increases p(HGNC:NLRC4, pmod(go:0006468 ! "protein phosphorylation", Ser)) + + + + + + + pubmed:23702978 + + g(HGNC:NLRP3, var("?")) positiveCorrelation path(MESH:"Cryopyrin-Associated Periodic Syndromes") + + + + + + + pubmed:23702978 + + path(MESH:"Cryopyrin-Associated Periodic Syndromes") positiveCorrelation g(HGNC:NLRP3, var("?")) + + + + + + + pubmed:23702978 + + bp(GO:"CD4-positive, alpha-beta T cell activation") decreases act(complex(GO:"NLRP1 inflammasome complex")) + + + + + + + pubmed:23702978 + + bp(GO:"CD4-positive, alpha-beta T cell activation") decreases act(complex(GO:"NLRP3 inflammasome complex")) + + + + + + + pubmed:23702978 + + p(HGNC:NLRP3, pmod(go:0017014 ! "protein nitrosylation")) decreases act(p(HGNC:NLRP3)) + + + + + + + pubmed:23702978 + + a(MESH:Interferons) increases p(HGNC:AIM2) + + + + + + + pubmed:23702978 + + a(MESH:Interferons) decreases p(HGNC:IL1B) + + + + + + + pubmed:23702978 + + a(MESH:Interferons) decreases act(complex(GO:"NLRP3 inflammasome complex")) + + + + + + + pubmed:23702978 + + m(HGNC:MIR223) decreases p(HGNC:NLRP3) + + + + + + + pubmed:23702978 + + act(complex(GO:apoptosome)) increases act(p(HGNC:CASP9)) + + + + + + + pubmed:23702978 + + p(HGNC:MAP3K7) association a(CHEBI:"calcium(2+)") + + + + + + + pubmed:23702978 + + p(HGNC:CASP9, pmod(go:0017014 ! "protein nitrosylation")) decreases act(p(HGNC:CASP9)) + + + + + + + pubmed:23702978 + + p(HGNC:CASP1, pmod(go:0017014 ! "protein nitrosylation")) decreases act(p(HGNC:CASP1)) + + + + + + + pubmed:23702978 + + complex(p(HGNC:CARD8), p(HGNC:CASP9)) decreases act(p(HGNC:CASP9)) + + + + + + + + + pubmed:23702978 + + complex(p(HGNC:CASP1), p(MGI:Casp12)) decreases act(p(HGNC:CASP1)) + + + + + + + + + pubmed:23702978 + + p(HGNC:CARD18) decreases act(p(HGNC:CASP1)) + + + + + + + pubmed:23702978 + + p(HGNC:CARD16) decreases act(p(HGNC:CASP1)) + + + + + + + pubmed:23702978 + + p(HGNC:CARD17) decreases p(HGNC:IL1B) + + + + + + + pubmed:23702978 + + p(HGNC:PYDC1) decreases complex(complex(GO:"inflammasome complex"), p(HGNC:PYCARD)) + + + + + + + pubmed:23702978 + + p(HGNC:PYDC2) decreases complex(complex(GO:"inflammasome complex"), p(HGNC:PYCARD)) + + + + + + + pubmed:23702978 + + p(MGI:Mefv) decreases tloc(p(MGI:Il1b), fromLoc(go:0005622 ! intracellular), toLoc(go:0005615 ! "extracellular space")) + + + + + + + pubmed:23702978 + + composite(p(FPLX:HSP90), p(HGNC:SUGT1)) increases act(p(HGNC:NLRP3)) + + + + + + + + + + + pubmed:24561250 + + composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) association p(HGNC:PYCARD) + + + + + + + pubmed:24561250 + + composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) association p(HGNC:PYCARD) + + + + + + + pubmed:24561250 + + composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) increases p(HGNC:IL1B) + + + + + + + pubmed:24561250 + + composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) increases p(HGNC:IL1B) + + + + + + + pubmed:24561250 + + composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) association p(HGNC:CASP1) + + + + + + + pubmed:24561250 + + composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) association p(HGNC:NLRP2) + + + + + + + pubmed:24561250 + + composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) increases p(HGNC:IL18) + + + + + + + + + pubmed:24561250 + + p(HGNC:NLRP2) association composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) + + + + + + + + + pubmed:24561250 + + p(INTERPRO:"Leucine-rich repeat-containing adjacent domain") partOf a(MESH:"NLR Proteins") + + + + + + + pubmed:24561250 + + p(INTERPRO:"NACHT-associated domain") partOf a(MESH:"NLR Proteins") + + + + + + + + + pubmed:24561250 + + p(INTERPRO:"DAPIN domain") partOf p(INTERPRO:"NACHT-associated domain") + + + + + + + pubmed:24561250 + + p(INTERPRO:"CARD domain") partOf p(INTERPRO:"NACHT-associated domain") + + + + + + + pubmed:24561250 + + p(INTERPRO:"BIR repeat") partOf p(INTERPRO:"NACHT-associated domain") + + + + + + + pubmed:24561250 + + a(MESH:"Pathogen-Associated Molecular Pattern Molecules") increases complex(GO:"inflammasome complex") + + + + + + + pubmed:24561250 + + a(MESH:"Pathogen-Associated Molecular Pattern Molecules") increases act(complex(GO:"inflammasome complex")) + + + + + + + pubmed:30988501 + + a(MESH:"Pathogen-Associated Molecular Pattern Molecules") decreases path(MESH:"Illness Behavior") + + + + + + + pubmed:24561250 + + complex(a(MESH:"NLR Proteins"), p(INTERPRO:"NACHT-associated domain")) increases complex(GO:"inflammasome complex") + + + + + + + pubmed:24561250 + + complex(p(HGNC:CASP1), p(HGNC:NLRP1), p(HGNC:PYCARD)) increases act(complex(GO:"NLRP1 inflammasome complex")) + + + + + + + pubmed:24561250 + + complex(p(HGNC:CASP1), p(HGNC:NLRP3), p(HGNC:PYCARD)) increases act(complex(GO:"NLRP3 inflammasome complex")) + + + + + + + pubmed:24561250 + + a(MESH:Bacteria) increases act(complex(GO:"inflammasome complex")) + + + + + + + pubmed:24561250 + + a(MESH:Fungi) increases act(complex(GO:"inflammasome complex")) + + + + + + + pubmed:24561250 + + a(CHEBI:"potassium aluminium sulfate") increases act(complex(GO:"inflammasome complex")) + + + + + + + pubmed:24561250 + + p(MGI:P2rx4) increases act(complex(GO:"NLRP1 inflammasome complex")) + + + + + + + pubmed:24561250 + + p(MGI:P2rx4) increases p(HGNC:IL1B) + + + + + + + pubmed:24561250 + + p(MGI:P2rx4) increases p(HGNC:IL1B) + + + + + + + pubmed:24561250 + + p(MGI:P2rx4) increases act(complex(GO:"inflammasome complex")) + + + + + + + pubmed:24561250 + + p(MGI:P2rx7) increases act(complex(GO:"NLRP1 inflammasome complex")) + + + + + + + pubmed:24561250 + + composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2), p(HGNC:P2RX7), p(HGNC:PANX1)) increases p(HGNC:IL1B) + + + + + + + + + pubmed:24561250 + + p(HGNC:PANX1) increases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) + + + + + + + pubmed:24561250 + + p(HGNC:PANX1) increases p(HGNC:IL1B) + + + + + + + pubmed:24561250 + + p(HGNC:PANX1) increases p(HGNC:IL18) + + + + + + + pubmed:24561250 + + a(CHEBI:hexadecanoate) increases complex(GO:"IPAF inflammasome complex") + + + + + + + pubmed:24561250 + + a(CHEBI:hexadecanoate) increases act(complex(GO:"IPAF inflammasome complex")) + + + + + + + + + + + pubmed:24561250 + + p(MGI:Nlrp3) increases p(MGI:Il1b) + + + + + + + pubmed:24561250 + + p(MGI:Nlrp3) increases bp(GO:"amyloid-beta formation") + + + + + + + pubmed:24561250 + + p(MGI:Nlrp3) increases a(MESH:Neuropathology) + + + + + + + pubmed:24561250 + + p(MGI:Nlrp3) decreases bp(GO:cognition) + + + + + + + pubmed:24561250 + + composite(a(CHEBI:hexadecanoate), p(HGNC:PYCARD)) increases p(HGNC:IL1B) + + + + + + + pubmed:24561250 + + composite(a(CHEBI:hexadecanoate), p(HGNC:NLRC4)) increases p(HGNC:IL1B) + + + + + + + pubmed:24561250 + + a(CHEBI:"saturated fatty acid") increases p(HGNC:IL1B) + + + + + + + pubmed:24561250 + + a(CHEBI:probenecid) decreases p(HGNC:PANX1) + + + + + + + pubmed:24561250 + + a(CHEBI:probenecid) decreases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) + + + + + + + pubmed:24561250 + + a(CHEBI:probenecid) decreases p(HGNC:IL1B) + + + + + + + pubmed:24561250 + + a(CHEBI:probenecid) decreases p(HGNC:IL18) + + + + + + + pubmed:24561250 + + a(CHEBI:probenecid) decreases act(complex(GO:"NLRP1 inflammasome complex")) + + + + + + + pubmed:24561250 + + a(CHEBI:probenecid) increases bp(GO:learning) + + + + + + + pubmed:24561250 + + a(PUBCHEM:6324599) decreases act(p(HGNC:P2RX7)) + + + + + + + pubmed:24561250 + + a(PUBCHEM:6324599) decreases composite(complex(GO:"inflammasome complex"), p(HGNC:NLRP2)) + + + + + + + pubmed:24561250 + + p(MGI:Casp1) increases bp(GO:"amyloid-beta formation") + + + + + + + pubmed:24561250 + + p(MGI:Casp1) increases a(MESH:Neuropathology) + + + + + + + pubmed:24561250 + + p(MGI:Casp1) decreases bp(GO:cognition) + + + + + + + pubmed:27314526 + + act(p(HGNC:PRSS3)) increases p(HGNC:IL18) + + + + + + + pubmed:27314526 + + act(p(FPLX:ELA)) increases p(HGNC:IL18) + + + + + + + pubmed:27314526 + + act(p(HGNC:CTSG)) increases p(HGNC:IL18) + + + + + + + pubmed:27314526 + + composite(complex(GO:"NLRP3 inflammasome complex"), p(HGNC:CASP1), p(HGNC:PYCARD)) increases act(p(HGNC:CASP1)) + + + + + + + pubmed:27314526 + + path(MESH:Periodontitis) decreases bp(GO:cognition) + + + + + + + pubmed:30988501 + + bp(GO:"neuron-glial cell signaling") increases bp(GO:cognition) + + + + + + + pubmed:30988501 + + bp(GO:"neuron-glial cell signaling") increases bp(GO:"social behavior") + + + + + + + pubmed:30988501 + + bp(GO:"neuron-glial cell signaling") increases bp(GO:learning) + + + + + + + pubmed:30988501 + + bp(GO:"immune system process") increases bp(GO:cognition) + + + + + + + pubmed:30988501 + + bp(GO:"immune system process") increases bp(GO:"social behavior") + + + + + + + pubmed:30988501 + + bp(GO:"immune system process") increases bp(GO:learning) + + + + + + + pubmed:30988501 + + p(HGNC:C1QBP) increases bp(GO:"complement-mediated synapse pruning") + + + + + + + pubmed:30988501 + + p(HGNC:C1QBP) increases deg(a(MESH:Neurons)) + + + + + + + pubmed:30988501 + + p(INTERPRO:"Chemokine receptor family") increases bp(GO:"central nervous system development") + + + + + + + pubmed:30988501 + + p(HGNC:ACKR3) increases bp(GO:"cell migration") + + + + + + + pubmed:30988501 + + a(MESH:"Extracellular Vesicles") increases bp(GO:"regulation of action potential firing rate") + + + + + + + pubmed:30988501 + + p(MESH:"Receptors, Antigen, T-Cell") increases bp(GO:neurogenesis) + + + + + + + pubmed:30988501 + + bp(MESH:Sleep) decreases a(MESH:"Waste Products") + + + + + + + pubmed:30988501 + + bp(MESH:Sleep) decreases path(CONSO:neurotoxicity) + + + + + + + pubmed:30988501 + + path(MESH:"Systemic Inflammatory Response Syndrome") increases path(MESH:"Illness Behavior") + + + + + + + pubmed:30988501 + + path(MESH:"Illness Behavior") increases path(MESH:"Mood Disorders") + + + + + + + pubmed:30988501 + + path(MESH:"Illness Behavior") increases path(MESH:"Social Behavior Disorders") + + + + + + + pubmed:30988501 + + path(MESH:"Illness Behavior") association bp(GO:cognition) + + + + + + + pubmed:30988501 + + path(MESH:"Illness Behavior") association bp(MESH:"Immunity, Cellular") + + + + + + + pubmed:30988501 + + path(MESH:"Social Behavior") association bp(MESH:"Immunity, Cellular") + + + + + + + pubmed:30988501 + + path(MESH:"Social Behavior Disorders") increases bp(MESH:Survival) + + + + + + + pubmed:30988501 + + p(MESH:"Receptors, Cytokine") increases act(a(MESH:Brain)) + + + + + + + pubmed:30988501 + + bp(GO:"monoamine transport") decreases path(CONSO:neurotoxicity) + + + + + + + pubmed:30988501 + + a(MESH:"Streptococcus pyogenes") increases path(MESH:Infection) + + + + + + + pubmed:30988501 + + a(MESH:"Streptococcus pyogenes") increases path(MESH:"Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections") + + + + + + + pubmed:30988501 + + a(MESH:"Streptococcus pyogenes") increases path(MESH:"Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections") + + + + + + + pubmed:30988501 + + a(MESH:"Streptococcus pyogenes") increases path(MESH:Chorea) + + + + + + + pubmed:30988501 + + path(MESH:"Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections") increases bp(MESH:"Molecular Mimicry") + + + + + + + pubmed:30988501 + + path(DOID:"rheumatic fever") association path(MESH:Chorea) + + + + + + + pubmed:30988501 + + path(MESH:"Streptococcal Infections") increases path(MESH:"Obsessive-Compulsive Disorder") + + + + + + + pubmed:30988501 + + path(MESH:"Streptococcal Infections") increases path(DOID:"tic disorder") + + + + + + + pubmed:30988501 + + path(MESH:"Streptococcal Infections") increases path(MESH:"Motor Disorders") + + + + + + + pubmed:30988501 + + path(MESH:"Cytomegalovirus Infections") increases path(HP:"Abnormal proportion of CD4+ effector memory cells") + + + + + + + pubmed:30988501 + + path(MESH:"Cytomegalovirus Infections") increases path(HP:"Reduced proportion of naive T cells") + + + + + + + pubmed:30988501 + + path(MESH:"Cytomegalovirus Infections") decreases bp(GO:cognition) + + + + + + + pubmed:30988501 + + path(MESH:"Cytomegalovirus Infections") decreases bp(GO:cognition) + + + + + + + pubmed:30988501 + + path(HP:"Helicobacter pylori infection") decreases bp(GO:cognition) + + + + + + + pubmed:30988501 + + a(MESH:"Herpesvirus 1, Human") decreases bp(GO:cognition) + + + + + + + pubmed:30988501 + + a(MESH:"Herpesvirus 1, Human") decreases bp(GO:cognition) + + + + + + + pubmed:30988501 + + a(MESH:"Herpesvirus 1, Human") positiveCorrelation path(DOID:"Alzheimer's disease") + + + + + + + pubmed:30988501 + + a(MESH:"Herpesvirus 1, Human") increases a(CHEBI:amyloid-beta, loc(GO:intracellular)) + + + + + + + pubmed:30988501 + + a(MESH:"Herpesvirus 1, Human") increases p(HGNC:MAPT, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:30988501 + + a(MESH:"Herpesvirus 1, Human") association path(MESH:"Plaque, Amyloid") + + + + + + + pubmed:30988501 + + a(MESH:"Herpesvirus 1, Human") decreases bp(GO:autophagy) + + + + + + + pubmed:30988501 + + a(MESH:"Herpesvirus 1, Human") decreases bp(MESH:"Antigen Presentation") + + + + + + + pubmed:30988501 + + a(MESH:"Herpesvirus 1, Human") increases p(HGNC:TLR4) + + + + + + + pubmed:30988501 + + a(MESH:"Herpesvirus 1, Human") increases p(HGNC:IFNA1) + + + + + + + pubmed:30988501 + + a(MESH:"Herpesvirus 1, Human") increases p(HGNC:IFNB1) + + + + + + + pubmed:30988501 + + a(MESH:"Herpesvirus 2, Human") decreases bp(GO:cognition) + + + + + + + pubmed:30988501 + + a(MESH:"Herpesvirus 2, Human") decreases bp(GO:cognition) + + + + + + + pubmed:30988501 + + path(MESH:Toxoplasmosis) decreases bp(GO:cognition) + + + + + + + pubmed:30988501 + + path(MESH:"HIV Infections") increases path(MESH:"Neurocognitive Disorders") + + + + + + + pubmed:30988501 + + path(MESH:"Antiretroviral Therapy, Highly Active") causesNoChange path(MESH:"Neurocognitive Disorders") + + + + + + + pubmed:30988501 + + bp(GO:pathogenesis) increases bp(GO:"regulation of gene expression, epigenetic") + + + + + + + pubmed:30988501 + + bp(GO:pathogenesis) positiveCorrelation path(DOID:"neurodegenerative disease") + + + + + + + pubmed:30988501 + + bp(GO:pathogenesis) increases path(DOID:"neurodegenerative disease") + + + + + + + pubmed:30988501 + + bp(GO:pathogenesis) decreases bp(GO:cognition) + + + + + + + pubmed:30988501 + + bp(MESH:"Antigen Presentation") increases path(HP:Autoimmunity) + + + + + + + pubmed:30988501 + + p(HGNC:IFNA1) biomarkerFor path(CONSO:neuroinflammation) + + + + + + + pubmed:30988501 + + p(HGNC:IFNA1) biomarkerFor path(CONSO:Neurodegeneration) + + + + + + + pubmed:30988501 + + bp(HP:"Autoimmune antibody positivity") increases path(HP:Autoimmunity) + + + + + + + pubmed:30988501 + + bp(HP:"Autoimmune antibody positivity") increases path(HP:"CNS demyelination") + + + + + + + pubmed:30988501 + + complex(GO:"MHC class II protein complex") increases path(HP:Autoimmunity) + + + + + + + pubmed:30988501 + + path(DOID:encephalomyelitis) isA path(DOID:"autoimmune disease of the nervous system") + + + + + + + pubmed:30988501 + + path(HP:"Recurrent upper respiratory tract infections") increases path(MESH:Recurrence) + + + + + + + pubmed:30988501 + + complex(a(MESH:Autoantibodies), a(MESH:Neuropil)) increases path(HP:Psychosis) + + + + + + + + + + + + + + + pubmed:30988501 + + complex(a(MESH:Autoantibodies), p(HGNCGENEFAMILY:"Gamma-aminobutyric acid type A receptor subunits")) increases path(DOID:encephalitis) + + + + + + + pubmed:30988501 + + complex(a(MESH:Autoantibodies), p(HGNCGENEFAMILY:"Glutamate ionotropic receptor AMPA type subunits")) decreases bp(GO:"regulation of synaptic plasticity") + + + + + + + pubmed:30988501 + + complex(a(MESH:Autoantibodies), p(HGNCGENEFAMILY:"Glutamate ionotropic receptor AMPA type subunits")) decreases bp(GO:"learning or memory") + + + + + + + pubmed:30988501 + + complex(a(MESH:Autoantibodies), p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) increases bp(GO:"microglial cell activation") + + + + + + + pubmed:30988501 + + complex(a(MESH:Autoantibodies), p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")) increases p(HGNC:C1QBP) + + + + + + + pubmed:30988501 + + path(DOID:"post-traumatic stress disorder") negativeCorrelation p(HGNC:IL6) + + + + + + + pubmed:30988501 + + path(DOID:"post-traumatic stress disorder") negativeCorrelation p(HGNC:IL2) + + + + + + + pubmed:30988501 + + path(DOID:"post-traumatic stress disorder") negativeCorrelation p(HGNC:IL1B) + + + + + + + pubmed:30988501 + + path(DOID:"post-traumatic stress disorder") negativeCorrelation p(HGNC:IL17A) + + + + + + + pubmed:30988501 + + path(DOID:"post-traumatic stress disorder") negativeCorrelation p(HGNC:CRP) + + + + + + + pubmed:30988501 + + path(MESH:Neuropsychiatry) association bp(MESH:"Immunity, Innate") + + + + + + + pubmed:30988501 + + path(MESH:"Hereditary Diffuse Leukoencephalopathy with Spheroids") negativeCorrelation bp(GO:"microglial cell activation") + + + + + + + pubmed:30988501 + + bp(MESH:"Gastrointestinal Microbiome") increases p(HGNC:IL17A) + + + + + + + pubmed:30988501 + + bp(MESH:"Immunity, Maternally-Acquired") positiveCorrelation path(DOID:"autism spectrum disorder") + + + + + + + pubmed:30988501 + + bp(MESH:"Immunity, Maternally-Acquired") negativeCorrelation bp(GO:"embryonic brain development") + + + + + + + pubmed:30988501 + + bp(GO:"embryonic brain development") negativeCorrelation bp(MESH:"Immunity, Maternally-Acquired") + + + + + + + pubmed:30988501 + + bp(GO:"embryonic brain development") association act(a(MESH:B-Lymphocytes)) + + + + + + + pubmed:30988501 + + bp(GO:"embryonic brain development") association bp(MESH:"Antibody Formation") + + + + + + + pubmed:30988501 + + complex(p(HGNC:CNTNAP2), p(MESH:"Immunoglobulin G")) increases path(MESH:"Neurodevelopmental Disorders") + + + + + + + pubmed:30988501 + + complex(p(HGNC:CNTNAP2), p(MESH:"Immunoglobulin G")) increases path(MESH:"Social Behavior Disorders") + + + + + + + + + pubmed:30988501 + + a(MESH:Steroids) decreases path(DOID:"multiple sclerosis") + + + + + + + pubmed:30988501 + + path(MESH:Plasmapheresis) decreases path(DOID:"multiple sclerosis") + + + + + + + pubmed:30988501 + + a(CHEBI:cyclophosphamide) decreases path(DOID:"multiple sclerosis") + + + + + + + pubmed:30988501 + + composite(a(CHEBI:minocycline), a(CHEBI:risperidone)) negativeCorrelation path(DOID:"autism spectrum disorder") + + + + + + + pubmed:30988501 + + path(MESH:"Psychosocial Deprivation") positiveCorrelation path(MESH:"Mental Disorders") + + + + + + + pubmed:30988501 + + path(MESH:"Psychosocial Deprivation") positiveCorrelation path(DOID:"multiple sclerosis") + + + + + + + pubmed:30988501 + + path(MESH:"Psychosocial Deprivation") increases bp(GO:"microglial cell activation") + + + + + + + pubmed:30988501 + + p(HGNC:CLDN5) decreases p(HGNC:IL6) + + + + + + + pubmed:30988501 + + a(MESH:"Synaptic Membranes") decreases path(MESH:Inflammation) + + + + + + + pubmed:10887109 + + path(MESH:"Growth and Development") increases p(HGNC:CD33, loc(MESH:"Myeloid Progenitor Cells")) + + + + + + + pubmed:10887109 + + path(MESH:"Growth and Development") regulates p(HGNC:CD33) + + + + + + + pubmed:10887109 + + complex(complex(GO:"receptor complex"), p(HGNC:CD22)) increases p(HGNC:CD22, pmod(go:0006468 ! "protein phosphorylation", Tyr)) + + + + + + + + + + + + + + + + + + + + + pubmed:10887109 + + p(HGNC:CD22, pmod(go:0006468 ! "protein phosphorylation", Tyr)) increases p(HGNC:PTPN6) + + + + + + + pubmed:10887109 + + p(HGNC:CD22, pmod(go:0006468 ! "protein phosphorylation", Tyr)) increases p(HGNC:PTPN11) + + + + + + + pubmed:10887109 + + p(HGNC:CD22, pmod(go:0006468 ! "protein phosphorylation", Tyr)) increases p(HGNC:INPP5D) + + + + + + + pubmed:10887109 + + complex(complex(GO:"receptor complex"), p(HGNC:FCGR2B)) increases p(HGNC:FCGR2B, pmod(go:0006468 ! "protein phosphorylation", Tyr)) + + + + + + + + + + + pubmed:10887109 + + p(HGNC:FCGR2B, pmod(go:0006468 ! "protein phosphorylation", Tyr)) increases p(HGNC:PTPN6) + + + + + + + pubmed:10887109 + + p(HGNC:FCGR2B, pmod(go:0006468 ! "protein phosphorylation", Tyr)) increases p(HGNC:PTPN11) + + + + + + + pubmed:10887109 + + p(HGNC:FCGR2B, pmod(go:0006468 ! "protein phosphorylation", Tyr)) increases p(HGNC:INPP5D) + + + + + + + pubmed:10887109 + + complex(complex(GO:"receptor complex"), p(HGNCGENEFAMILY:"Killer cell immunoglobulin like receptors")) increases p(HGNCGENEFAMILY:"Killer cell immunoglobulin like receptors", pmod(go:0006468 ! "protein phosphorylation", Tyr)) + + + + + + + + + + + + + + + pubmed:10887109 + + p(HGNCGENEFAMILY:"Killer cell immunoglobulin like receptors", pmod(go:0006468 ! "protein phosphorylation", Tyr)) increases p(HGNC:PTPN6) + + + + + + + pubmed:10887109 + + p(HGNCGENEFAMILY:"Killer cell immunoglobulin like receptors", pmod(go:0006468 ! "protein phosphorylation", Tyr)) increases p(HGNC:PTPN11) + + + + + + + pubmed:10887109 + + p(HGNCGENEFAMILY:"Killer cell immunoglobulin like receptors", pmod(go:0006468 ! "protein phosphorylation", Tyr)) increases p(HGNC:INPP5D) + + + + + + + pubmed:10887109 + + complex(complex(GO:"receptor complex"), p(HGNC:PILRB)) increases p(HGNC:PILRB, pmod(go:0006468 ! "protein phosphorylation", Tyr)) + + + + + + + + + + + pubmed:10887109 + + p(HGNC:PILRB, pmod(go:0006468 ! "protein phosphorylation", Tyr)) increases p(HGNC:PTPN6) + + + + + + + pubmed:10887109 + + p(HGNC:PILRB, pmod(go:0006468 ! "protein phosphorylation", Tyr)) increases p(HGNC:PTPN11) + + + + + + + pubmed:10887109 + + p(HGNC:PILRB, pmod(go:0006468 ! "protein phosphorylation", Tyr)) increases p(HGNC:INPP5D) + + + + + + + pubmed:10887109 + + complex(complex(GO:"receptor complex"), p(HGNC:CD33)) increases p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 340), pmod(go:0006468 ! "protein phosphorylation", Tyr, 358)) + + + + + + + pubmed:10887109 + + p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 340), pmod(go:0006468 ! "protein phosphorylation", Tyr, 358)) increases p(HGNC:PTPN6) + + + + + + + pubmed:10887109 + + p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 340), pmod(go:0006468 ! "protein phosphorylation", Tyr, 358)) increases p(HGNC:PTPN11) + + + + + + + pubmed:10887109 + + p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 340), pmod(go:0006468 ! "protein phosphorylation", Tyr, 358)) increases p(HGNC:INPP5D) + + + + + + + + + pubmed:10887109 + + p(HGNC:PTPN11) increases complex(p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation")), p(HGNC:PTPN11, pmod(go:0006468 ! "protein phosphorylation", Tyr))) + + + + + + + pubmed:10887109 + + p(HGNC:PTPN11) increases p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 340)) + + + + + + + pubmed:10887109 + + p(HGNC:PTPN11) increases p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 358)) + + + + + + + + + + + pubmed:10887109 + + p(HGNC:PTPN11) increases complex(p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation")), p(HGNC:PTPN11)) + + + + + + + + + + + + + + + + + pubmed:10887109 + + p(HGNC:INPP5D) decreases complex(p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation")), p(HGNC:INPP5D)) + + + + + + + pubmed:10887109 + + a(PUBCHEM:24978557) increases p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr)) + + + + + + + + + + + + + + + + + + + + + pubmed:10887109 + + act(p(HGNC:ZAP70), ma(go:0016301 ! "kinase activity")) causesNoChange p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + + + pubmed:10887109 + + act(p(HGNC:LCK, var("p.Lys273Arg")), ma(go:0016301 ! "kinase activity")) causesNoChange p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:10887109 + + act(p(HGNC:SYK, var("p.Lys395Arg")), ma(go:0016301 ! "kinase activity")) causesNoChange p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + pubmed:10887109 + + act(p(HGNC:ZAP70, var("p.Lys369Arg")), ma(go:0016301 ! "kinase activity")) causesNoChange p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation")) + + + + + + + + + + + pubmed:10887109 + + p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 340)) increases complex(p(HGNC:CD33), p(HGNC:PTPN6)) + + + + + + + pubmed:10887109 + + p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 340)) increases complex(p(HGNC:CD33), p(HGNC:PTPN11)) + + + + + + + pubmed:10887109 + + p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 340)) regulates bp(GO:"macrophage activation") + + + + + + + + + + + + + + + pubmed:10887109 + + p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 358)) increases complex(p(HGNC:CD33), p(HGNC:PTPN6)) + + + + + + + pubmed:10887109 + + p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 358)) increases complex(p(HGNC:CD33), p(HGNC:PTPN11)) + + + + + + + pubmed:10887109 + + p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 358)) regulates bp(GO:"macrophage activation") + + + + + + + + + + + + + + + + + pubmed:10887109 + + p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 358)) decreases complex(p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 358)), p(HGNC:PTPN6, var("p.Arg30Lys"))) + + + + + + + + + pubmed:10887109 + + p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 358)) decreases complex(p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 358)), p(HGNC:PTPN6, var("p.Arg139Lys"))) + + + + + + + pubmed:10887109 + + complex(p(HGNC:CD33), p(HGNC:PTPN6)) increases act(p(HGNC:PTPN6)) + + + + + + + pubmed:10887109 + + composite(p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 340)), p(HGNC:PTPN6)) increases complex(p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 340)), p(HGNC:PTPN6)) + + + + + + + pubmed:10887109 + + composite(p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 340)), p(HGNC:PTPN6)) increases complex(p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 340)), p(HGNC:PTPN6)) + + + + + + + pubmed:10887109 + + composite(p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 340)), p(HGNC:PTPN11)) increases complex(p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 340)), p(HGNC:PTPN11)) + + + + + + + pubmed:10887109 + + composite(p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 358)), p(HGNC:PTPN11)) increases complex(p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 358)), p(HGNC:PTPN11)) + + + + + + + pubmed:10887109 + + composite(p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 358)), p(HGNC:PTPN6)) causesNoChange complex(p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 358)), p(HGNC:PTPN6)) + + + + + + + pubmed:10887109 + + composite(p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 358)), p(HGNC:PTPN6)) decreases complex(p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 358)), p(HGNC:PTPN6)) + + + + + + + pubmed:10887109 + + p(HGNCGENEFAMILY:"Killer cell immunoglobulin like receptors", pmod(go:0006468 ! "protein phosphorylation", Tyr), var("p.Val?Ile")) causesNoChange act(p(HGNC:PTPN6), ma(GO:"phosphatase activity")) + + + + + + + pubmed:10887109 + + p(HGNCGENEFAMILY:"Killer cell immunoglobulin like receptors", pmod(go:0006468 ! "protein phosphorylation", Tyr), var("p.Val?Leu")) causesNoChange act(p(HGNC:PTPN6), ma(GO:"phosphatase activity")) + + + + + + + pubmed:10887109 + + p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 340), var("p.Leu343Val")) decreases act(p(HGNC:PTPN6), ma(GO:"phosphatase activity")) + + + + + + + pubmed:10887109 + + p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 358), var("p.Leu361Val")) decreases complex(p(HGNC:CD33), p(HGNC:PTPN6)) + + + + + + + pubmed:10887109 + + act(complex(p(HGNC:PTPN6), p(MESH:Phosphopeptides)), ma(GO:"SH2 domain binding")) increases act(p(HGNC:PTPN6), ma(GO:"phosphatase activity")) + + + + + + + pubmed:10887109 + + act(complex(p(HGNC:PTPN6), p(MESH:Phosphopeptides)), ma(GO:"SH2 domain binding")) increases p(HGNC:PTPN6) + + + + + + + + + pubmed:10887109 + + p(HGNC:PTPN6, var("p.Arg30Lys")) decreases complex(p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 340)), p(HGNC:PTPN6)) + + + + + + + + + pubmed:10887109 + + p(HGNC:PTPN6, var("p.Arg136Lys")) increases complex(p(HGNC:CD33, pmod(go:0006468 ! "protein phosphorylation", Tyr, 340)), p(HGNC:PTPN6)) + + + + + + + + + pubmed:10887109 + + complex(p(HGNC:CD33), p(HGNC:FCGR1A), p(HGNC:IFNG)) decreases a(CHEBI:"calcium(2+)") + + + + + + + + + + + pubmed:10887109 + + act(p(HGNC:FCGR1A)) association p(HGNC:CD33) + + + + + + + pubmed:10887109 + + p(HGNC:FCGR1A) increases bp(GO:"calcium ion import") + + + + + + + pubmed:10887109 + + complex(p(HGNC:FCGR1A), p(HGNC:IFNG)) increases a(CHEBI:"calcium(2+)") + + + + + + + pubmed:10887109 + + p(HGNC:PTPN6, var("p.Cys453Ser")) increases act(p(HGNC:CD33)) + + + + + + + pubmed:10887109 + + p(HGNC:PTPN6, var("p.Cys453Ser")) increases act(p(HGNC:FCGR1A)) + + + + + + + pubmed:10887109 + + p(HGNC:PTPN6, var("p.Cys453Ser")) increases bp(GO:"calcium ion import") + + + + + + +

Curation Quality

+
+
+
+ + + +

Namespaces

+
+

+ Namespace References + 21 +

+

+ This section lists all of the namespaces that are defined in the original BEL document. +

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +
KeywordURL
CHEBIhttps://raw.githubusercontent.com/pharmacome/conso/c328ad964c08967a0417a887510b97b965a62fa5/external/chebi-names.belns
CONSOhttps://raw.githubusercontent.com/pharmacome/conso/501ceccdc9a27d97edbdc48a89ebe8e1dd3626e9/export/conso-names.belns
DOIDhttps://raw.githubusercontent.com/pharmacome/terminology/c0c576e3d3ab9b25a3982251a4ee2fd7c49e1679/external/doid-names.belns
DRUGBANKhttps://raw.githubusercontent.com/pharmacome/terminology/c328ad964c08967a0417a887510b97b965a62fa5/external/drugbank-names.belns
ECCODEhttps://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/ec-code.belns
EFOhttps://raw.githubusercontent.com/pharmacome/conso/5d2c2ea6f7112421cc8089a3f021a75ab60bb373/external/efo-names.belns
FBhttps://raw.githubusercontent.com/pharmacome/terminology/c328ad964c08967a0417a887510b97b965a62fa5/external/fb-names.belns
FPLXhttps://raw.githubusercontent.com/sorgerlab/famplex/e8ae9926ff95266032cb74f77973c84939bffbeb/export/famplex.belns
GOhttps://raw.githubusercontent.com/pharmacome/conso/d9d270e11aac480542c412d4222983a5f042b8ae/external/go-names.belns
HBPhttps://raw.githubusercontent.com/pharmacome/terminology/c328ad964c08967a0417a887510b97b965a62fa5/export/hbp-names.belns
HGNChttps://raw.githubusercontent.com/pharmacome/conso/c328ad964c08967a0417a887510b97b965a62fa5/external/hgnc-names.belns
HGNCGENEFAMILYhttps://raw.githubusercontent.com/pharmacome/conso/c328ad964c08967a0417a887510b97b965a62fa5/external/hgnc.genefamily-names.belns
HPhttps://raw.githubusercontent.com/pharmacome/conso/d9d270e11aac480542c412d4222983a5f042b8ae/external/hp-names.belns
INTERPROhttps://raw.githubusercontent.com/pharmacome/terminology/c328ad964c08967a0417a887510b97b965a62fa5/external/interpro-names.belns
MESHhttps://raw.githubusercontent.com/pharmacome/conso/f02c6ad4a4791a8ed45448513b9de8c8f1b00c87/external/mesh-names.belns
MGIhttps://arty.scai.fraunhofer.de/artifactory/bel/namespace/mgi-mouse-genes/mgi-mouse-genes-20170725.belns
MIRBASEhttps://raw.githubusercontent.com/pharmacome/terminology/c328ad964c08967a0417a887510b97b965a62fa5/external/mirbase-names.belns
NCBIGENEhttps://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/entrez.belns
NIFThttps://raw.githubusercontent.com/neurommsig/neurommsig-terminology/c45db68bb47b28023ec134049429320da6a9d631/terminologies/neuroimaging-feature-terminology.belns
PFAMhttps://raw.githubusercontent.com/pharmacome/terminology/8ccfed235e418e4c8aa576f9a5ef0f838e794c7f/external/pfam-names.belns
RGDhttps://arty.scai.fraunhofer.de/artifactory/bel/namespace/rgd-rat-genes/rgd-rat-genes-20170725.belns
+ + + + + + + + +
+ +

Annotations

+
+

+ Annotation References + 12 +

+

+ This section lists all of the annotations that are defined in the original BEL document. +

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +
KeywordURL
Anatomyhttps://arty.scai.fraunhofer.de/artifactory/bel/annotation/anatomy/anatomy-20170511.belanno
Cellhttps://arty.scai.fraunhofer.de/artifactory/bel/annotation/cell/cell-20170511.belanno
CellLinehttps://arty.scai.fraunhofer.de/artifactory/bel/annotation/cell-line/cell-line-20170511.belanno
CellStructurehttps://arty.scai.fraunhofer.de/artifactory/bel/annotation/cell-structure/cell-structure-20170511.belanno
Confidencehttps://arty.scai.fraunhofer.de/artifactory/bel/annotation/confidence/confidence-1.0.0.belanno
Diseasehttps://arty.scai.fraunhofer.de/artifactory/bel/annotation/disease/disease-20170511.belanno
Genderhttps://arty.scai.fraunhofer.de/artifactory/bel/annotation/gender/gender-1.0.0.belanno
MeSHAnatomyhttps://arty.scai.fraunhofer.de/artifactory/bel/annotation/mesh-anatomy/mesh-anatomy-20170511.belanno
MeSHDiseasehttps://arty.scai.fraunhofer.de/artifactory/bel/annotation/mesh-diseases/mesh-diseases-20170511.belanno
Specieshttps://arty.scai.fraunhofer.de/artifactory/bel/annotation/species-taxonomy-id/species-taxonomy-id-20170511.belanno
Subgraphhttps://arty.scai.fraunhofer.de/artifactory/bel/annotation/neurommsig/neurommsig-1.0.3.belanno
TextLocationhttps://arty.scai.fraunhofer.de/artifactory/bel/annotation/text-location/text-location-1.0.1.belanno
+ + + + +

+ Locally Defined Annotations + 35 +

+

+ The source BEL document contained annotations defined as a list. Click each link to export + the list definition as a BELANNO file that can hosted externally to promote + re-usability and interoperability. After, you can replace the list definition in the source + BEL with a SET ANNOTATION X AS URL "Y" definition. +

+
    + +
  • + AssayType +
    • + +
  • + Braak_Stage +
    • + +
  • + Cell_Line +
    • + +
  • + Condition +
    • + +
  • + Disease_Progression +
    • + +
  • + Duration +
    • + +
  • + Enzyme_Acitvity +
    • + +
  • + ExpMethod +
    • + +
  • + Half_life +
    • + +
  • + HasQuantitativeInformation +
    • + +
  • + HBP_Disease +
    • + +
  • + IC50 +
    • + +
  • + Ki +
    • + +
  • + Km +
    • + +
  • + Km_ATP +
    • + +
  • + MeasurementRelation +
    • + +
  • + MeasurementType +
    • + +
  • + MeasurementUnits +
    • + +
  • + MeasurementValue +
    • + +
  • + Method +
    • + +
  • + MouseStrain +
    • + +
  • + PublicationType +
    • + +
  • + Published +
    • + +
  • + Research_Model +
    • + +
  • + Study_Group +
    • + +
  • + Substrate_Concentration +
    • + +
  • + Tau_Antibody +
    • + +
  • + Tau_Domain +
    • + +
  • + Tau_Epitope +
    • + +
  • + Tau_Motif +
    • + +
  • + Tau_State +
    • + +
  • + Tau_Structure +
    • + +
  • + TauIsoform +
    • + +
  • + TauIsoformGradient +
    • + +
  • + Vmax +
    • + +
+ + + +
+ +

Warnings

+
+ + + + + + + + +

All Errors + 55 +

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +
PathLineBELMessage
/Users/cthoyt/dev/conib/conib/ms/correale2017.bel303path(MESH:"Epstein-Barr Virus Infections") -- p(NCBIGENE:3783744, loc(MESH:"Plasma Cells")"3783744" is not in the NCBIGENE namespace
/Users/cthoyt/dev/conib/conib/receptors/nordberg2001.bel158bp(GO:aging) negativeCorrelation r(CONSO:"alpha-4-containing nAChR")RNA CONSO:"alpha-4-containing nAChR" should be encoded as one of: Complex
/Users/cthoyt/dev/conib/conib/receptors/nordberg2001.bel159bp(GO:aging) negativeCorrelation r(CONSO:"alpha-7-containing nAChR")RNA CONSO:"alpha-7-containing nAChR" should be encoded as one of: Complex
/Users/cthoyt/dev/conib/conib/receptors/zoli2018.bel218p(MESH:"Receptors, Nicotinic",loc(MESH:"GABAergic Neurons")) -- a(CONSO:neurotransmitters)"neurotransmitters" is not in the CONSO namespace
/Users/cthoyt/dev/conib/conib/receptors/zoli2018.bel219p(MESH:"Receptors, Nicotinic") reg sec(a(CONSO:neurotransmitters))"neurotransmitters" is not in the CONSO namespace
/Users/cthoyt/dev/conib/conib/immunotherapy/kontsekova2014.bel117p(CONSO:DC8E8) -- path(CONSO:"Braak_Stage I")Pathology CONSO:"Braak_Stage I" should be encoded as one of: miRNA, Gene, Complex, RNA, Abundance, Protein
/Users/cthoyt/dev/conib/conib/er-stress/doyle2011.bel551SET MeSHDisease = "Hypoxia""MeSHDisease" is not defined
/Users/cthoyt/dev/conib/conib/er-stress/doyle2011.bel568UNSET MeSHDisease"MeSHDisease" is not defined
/Users/cthoyt/dev/conib/conib/tau/dennissen2016.bel157p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) -- a(CONSO:"Tau epitope, 12E8")Abundance CONSO:"Tau epitope, 12E8" should be encoded as one of: Protein
/Users/cthoyt/dev/conib/conib/tau/dennissen2016.bel158p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del"),var("p.Ile277Pro"),var("p.Ile308Pro")) -- a(CONSO:"Tau epitope, 12E8")Abundance CONSO:"Tau epitope, 12E8" should be encoded as one of: Protein
/Users/cthoyt/dev/conib/conib/tau/dennissen2016.bel165p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) -- a(CONSO:"Tau epitope, PHF1")Abundance CONSO:"Tau epitope, PHF1" should be encoded as one of: Protein
/Users/cthoyt/dev/conib/conib/tau/dennissen2016.bel166p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del"),var("p.Ile277Pro"),var("p.Ile308Pro")) -- a(CONSO:"Tau epitope, PHF1")Abundance CONSO:"Tau epitope, PHF1" should be encoded as one of: Protein
/Users/cthoyt/dev/conib/conib/tau/dennissen2016.bel174p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) neg a(CONSO:"Tau epitope, AT180")Abundance CONSO:"Tau epitope, AT180" should be encoded as one of: Protein
/Users/cthoyt/dev/conib/conib/tau/dennissen2016.bel175p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del")) pos a(CONSO:"Tau epitope, AT8")Abundance CONSO:"Tau epitope, AT8" should be encoded as one of: Protein
/Users/cthoyt/dev/conib/conib/tau/dennissen2016.bel176p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del"),var("p.Ile277Pro"),var("p.Ile308Pro")) neg a(CONSO:"Tau epitope, AT180")Abundance CONSO:"Tau epitope, AT180" should be encoded as one of: Protein
/Users/cthoyt/dev/conib/conib/tau/dennissen2016.bel177p(CONSO:"Tau isoform F (441 aa)", var("p.Lys280del"),var("p.Ile277Pro"),var("p.Ile308Pro")) pos a(CONSO:"Tau epitope, AT8")Abundance CONSO:"Tau epitope, AT8" should be encoded as one of: Protein
/Users/cthoyt/dev/conib/conib/tau/tarasoffconway2015.bel94act(a(CONSO:"Glymphatic System")) -| a(CHEBI:"amyloid-beta",loc(GO:"extracellular region"))"Glymphatic System" is not in the CONSO namespace
/Users/cthoyt/dev/conib/conib/tau/tarasoffconway2015.bel103act(p(HGNC:AQP4)) -> act(a(CONSO:"Glymphatic System"))"Glymphatic System" is not in the CONSO namespace
/Users/cthoyt/dev/conib/conib/tau/tarasoffconway2015.bel104act(a(CONSO:"Glymphatic System")) -| a(CHEBI:"amyloid-beta",loc(GO:"extracellular region"))"Glymphatic System" is not in the CONSO namespace
/Users/cthoyt/dev/conib/conib/tau/tarasoffconway2015.bel230a(CONSO:"amyloid-beta polypeptide 38") isA a(CHEBI:"amyloid-beta")"amyloid-beta polypeptide 38" is not in the CONSO namespace
/Users/cthoyt/dev/conib/conib/tau/tarasoffconway2015.bel423bp(CONSO:"perivascular drainage pathways") -| a(CHEBI:"amyloid-beta")"perivascular drainage pathways" is not in the CONSO namespace
/Users/cthoyt/dev/conib/conib/tau/tarasoffconway2015.bel424path(MESH:"Alzheimer Disease") neg bp(CONSO:"perivascular drainage pathways")"perivascular drainage pathways" is not in the CONSO namespace
/Users/cthoyt/dev/conib/conib/tau/tarasoffconway2015.bel425path(MESH:"Cerebral Amyloid Angiopathy") neg bp(CONSO:"perivascular drainage pathways")"perivascular drainage pathways" is not in the CONSO namespace
/Users/cthoyt/dev/conib/conib/tau/tarasoffconway2015.bel431g(CONSO:"APOE e4") neg bp(CONSO:"perivascular drainage pathways")"perivascular drainage pathways" is not in the CONSO namespace
/Users/cthoyt/dev/conib/conib/tau/tarasoffconway2015.bel439path(CONSO:"high-fat prenatal maternal diet") -| deg(a(CHEBI:"amyloid-beta"))"high-fat prenatal maternal diet" is not in the CONSO namespace
/Users/cthoyt/dev/conib/conib/tau/tarasoffconway2015.bel448p(MGI:Aqp4) -> act(a(CONSO:"Glymphatic System"))"Glymphatic System" is not in the CONSO namespace
/Users/cthoyt/dev/conib/conib/tau/tarasoffconway2015.bel449act(a(CONSO:"Glymphatic System")) -| a(CHEBI:"amyloid-beta")"Glymphatic System" is not in the CONSO namespace
/Users/cthoyt/dev/conib/conib/tau/tarasoffconway2015.bel462path(MESH:Sleep) -> bp(CONSO:"glymphatic bulk flow")"glymphatic bulk flow" is not in the CONSO namespace
/Users/cthoyt/dev/conib/conib/tau/xin2018.bel106a(CONSO:"20 S Proteasome") -> bp(GO:"proteasomal ubiquitin-independent protein catabolic process")Abundance CONSO:"20 S Proteasome" should be encoded as one of: Protein
/Users/cthoyt/dev/conib/conib/tau/xin2018.bel134act(a(MESH:Microglia)) -> bp(CONSO:Neurodegeneration)BiologicalProcess CONSO:Neurodegeneration should be encoded as one of: Pathology
/Users/cthoyt/dev/conib/conib/tau/xin2018.bel241a(CHEBI:"amyloid-beta") -> bp(CONSO:"mitochondrial dysfunction")BiologicalProcess CONSO:"mitochondrial dysfunction" should be encoded as one of: Pathology
/Users/cthoyt/dev/conib/conib/tau/xin2018.bel274a(CONSO:"APOE e4") -| deg(a(CHEBI:"amyloid-beta"))Abundance CONSO:"APOE e4" should be encoded as one of: Gene
/Users/cthoyt/dev/conib/conib/tau/xin2018.bel593a(CONSO:"APOE e4") -| deg(a(CHEBI:"amyloid-beta"))Abundance CONSO:"APOE e4" should be encoded as one of: Gene
/Users/cthoyt/dev/conib/conib/tardbp/prasad2019.bel1876p(NCBIGENE:850633) -> deg(p(CONSO:"TDP-43 aggregates"))"850633" is not in the NCBIGENE namespace
/Users/cthoyt/dev/conib/conib/tardbp/prasad2019.bel1877p(NCBIGENE:850633) -> deg(p(HGNC:"FUS", pmod(MESH:"Protein Aggregates")))"850633" is not in the NCBIGENE namespace
/Users/cthoyt/dev/conib/conib/tardbp/prasad2019.bel1878p(NCBIGENE:850633) -> deg(a(CONSO:"alpha-synuclein aggregates"))"850633" is not in the NCBIGENE namespace
/Users/cthoyt/dev/conib/conib/tardbp/prasad2019.bel1885p(NCBIGENE:850633, var("p.Ala503Val")) -| p(CONSO:"TDP-43 aggregates")"850633" is not in the NCBIGENE namespace
/Users/cthoyt/dev/conib/conib/tardbp/prasad2019.bel1886p(NCBIGENE:850633, var("p.Ala503Val")) -| p(HGNC:"TARDBP", loc(GO:"nucleus"))"850633" is not in the NCBIGENE namespace
/Users/cthoyt/dev/conib/conib/tardbp/prasad2019.bel1887p(NCBIGENE:850633, var("p.Ala503Ser")) -| p(CONSO:"TDP-43 aggregates")"850633" is not in the NCBIGENE namespace
/Users/cthoyt/dev/conib/conib/tardbp/prasad2019.bel1888p(NCBIGENE:850633, var("p.Ala503Ser")) -| p(HGNC:"TARDBP", loc(GO:"nucleus"))"850633" is not in the NCBIGENE namespace
/Users/cthoyt/dev/conib/conib/tardbp/prasad2019.bel1889p(NCBIGENE:850633, var("p.Ala503Cys")) -| p(CONSO:"TDP-43 aggregates")"850633" is not in the NCBIGENE namespace
/Users/cthoyt/dev/conib/conib/tardbp/prasad2019.bel1890p(NCBIGENE:850633, var("p.Ala503Cys")) -| p(HGNC:"TARDBP", loc(GO:"nucleus"))"850633" is not in the NCBIGENE namespace
/Users/cthoyt/dev/conib/conib/tardbp/prasad2019.bel1891p(NCBIGENE:850633, var("p.Val426Leu")) -| p(CONSO:"TDP-43 aggregates")"850633" is not in the NCBIGENE namespace
/Users/cthoyt/dev/conib/conib/tardbp/prasad2019.bel1892p(NCBIGENE:850633, var("p.Val426Leu")) -| p(HGNC:"TARDBP", loc(GO:"nucleus"))"850633" is not in the NCBIGENE namespace
/Users/cthoyt/dev/conib/conib/tardbp/prasad2019.bel1894p(NCBIGENE:850633, var("p.Ala503Val")) -| p(HGNC:"TARDBP", var("p.Met337Val"))"850633" is not in the NCBIGENE namespace
/Users/cthoyt/dev/conib/conib/tardbp/prasad2019.bel1895p(NCBIGENE:850633, var("p.Ala503Ser")) -| p(HGNC:"TARDBP", var("p.Met337Val"))"850633" is not in the NCBIGENE namespace
/Users/cthoyt/dev/conib/conib/tardbp/prasad2019.bel1896p(NCBIGENE:850633, var("p.Ala503Cys")) -| p(HGNC:"TARDBP", var("p.Met337Val"))"850633" is not in the NCBIGENE namespace
/Users/cthoyt/dev/conib/conib/tardbp/prasad2019.bel1897p(NCBIGENE:850633, var("p.Val426Leu")) -| p(HGNC:"TARDBP", var("p.Met337Val"))"850633" is not in the NCBIGENE namespace
/Users/cthoyt/dev/conib/conib/tardbp/prasad2019.bel1908p(NCBIGENE:850633, var("p.Ala503Val")) -> deg(p(CONSO:"TDP-43 aggregates"))"850633" is not in the NCBIGENE namespace
/Users/cthoyt/dev/conib/conib/tardbp/prasad2019.bel1909p(NCBIGENE:850633, var("p.Ala503Ser")) -> deg(p(CONSO:"TDP-43 aggregates"))"850633" is not in the NCBIGENE namespace
/Users/cthoyt/dev/conib/conib/tardbp/prasad2019.bel1910p(NCBIGENE:850633, var("p.Ala503Val")) -> deg(p(HGNC:"FUS", pmod(MESH:"Protein Aggregates")))"850633" is not in the NCBIGENE namespace
/Users/cthoyt/dev/conib/conib/tardbp/prasad2019.bel1911p(NCBIGENE:850633, var("p.Ala503Ser")) -> deg(p(HGNC:"FUS", pmod(MESH:"Protein Aggregates")))"850633" is not in the NCBIGENE namespace
/Users/cthoyt/dev/conib/conib/tardbp/prasad2019.bel1912p(NCBIGENE:850633, var("p.Ala503Val")) -> deg(a(CONSO:"alpha-synuclein aggregates"))"850633" is not in the NCBIGENE namespace
/Users/cthoyt/dev/conib/conib/tardbp/prasad2019.bel1913p(NCBIGENE:850633, var("p.Ala503Ser")) -> deg(a(CONSO:"alpha-synuclein aggregates"))"850633" is not in the NCBIGENE namespace
/Users/cthoyt/dev/conib/conib/tardbp/prasad2019.bel1921p(NCBIGENE:855725) -| p(CONSO:"TDP-43 aggregates")"855725" is not in the NCBIGENE namespace
+ +
+ +

Biogrammar

+
-

- Unstable Triplets - 154 -

-

- Like unstable pairs, unstable triplets require additional context to understand their - mechanisms of regulation. -

-
-
Chaotic Triplets
-
A triplet of nodes that mutually increase each other, such as when A - increases B, B increases C, and C increases A. -
-
Dampened Triplets
-
A triplet of nodes that mutually decreases each other, such as when A - decreases B, B decreases C, and C decreases A. -
-
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
TypeNode ANode BNode C
Chaoticcomplex(p(HGNC:FYN), p(HGNC:MAPT))p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
Chaoticp(HGNC:APP, frag("672_713"))p(HGNC:BACE1)path(MESH:"Alzheimer Disease")
Chaotica(MESH:Microglia)complex(GO:"NF-kappaB complex")p(HGNC:TNF)
Chaotica(CHEBI:"amyloid-beta")p(FPLX:NFkappaB)p(HGNC:BACE1)
Chaotica(CHEBI:"amyloid-beta")complex(GO:"inflammasome complex")p(HGNC:IL1B)
Chaoticp(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B")p(MGI:"oncostatin M")path(MESH:Glioblastoma)
Chaotica(CHEBI:acetylcholine)bp(GO:"action potential initiation")p(HGNC:CHRNA7)
Chaotica(CHEBI:"amyloid-beta polypeptide 42")complex(GO:"NF-kappaB complex")p(HGNC:BACE1)
Chaoticbp(GO:"response to misfolded protein")p(HGNC:ERN1)p(HGNC:XBP1)
Chaotica(HBP:"Tau fibrils")p(MGI:Tfeb)p(MGI:Tfeb)
Chaoticcomplex(GO:"proteasome complex")p(FPLX:PKA)p(FPLX:PKA, pmod(Ub))
Chaotica(CHEBI:"amyloid-beta")complex(GO:"NF-kappaB complex")p(HGNC:BACE1)
Chaoticbp(GO:"apoptotic process")p(HGNC:SNCA)p(HGNCGENEFAMILY:Calpains)
Chaoticp(HGNC:AK1)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))path(MESH:"Alzheimer Disease")
Chaotica(CHEBI:"amyloid-beta")bp(GO:"MAPK cascade")p(HGNC:CHRNA7)
Chaotica(CHEBI:"amyloid-beta")p(FPLX:CAPN)p(HGNC:MAPT)
Chaoticp(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B")p(MGI:"interleukin 1 alpha")path(MESH:Glioblastoma)
Chaotica(CHEBI:"amyloid-beta")bp(GO:phagocytosis)complex(GO:"NLRP3 inflammasome complex")
Chaotica(CHEBI:"amyloid-beta")bp(GO:"JNK cascade")bp(GO:autophagy)
Chaoticbp(GO:"ERAD pathway")p(HGNC:ATF6)p(MESH:Proteins, pmod(HBP:misfolded))
Chaotica(CHEBI:"glutamate(1-)")a(GO:"excitatory synapse")complex(GO:"NF-kappaB complex")
Chaoticbp(GO:autophagy)p(HGNC:SQSTM1)p(MESH:Proteins, pmod(HBP:misfolding))
Chaotica(HBP:"Tau aggregates")p(HGNC:MAPT, pmod(Ph, Tyr))p(HGNC:SYK)
Chaoticbp(GO:autophagy)p(MESH:"PERK kinase")p(MESH:Proteins, pmod(HBP:misfolded))
Chaoticp(HGNC:GSK3B)p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ph, Ser, 404))
Chaoticp(FPLX:ERK)p(FPLX:NFkappaB)p(HGNC:TNF)
Chaotica(CHEBI:"amyloid-beta")complex(GO:"inflammasome complex")p(HGNC:IL18)
Chaotica(MESH:"Neurofibrillary Tangles")p(HGNC:MAPT)p(HGNC:MAPT)
Chaotica(HBP:"Tau aggregates")a(HBP:"Tau aggregates")p(HGNC:SYK)
Chaotica(MESH:"Neurofibrillary Tangles")p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))path(MESH:"Alzheimer Disease")
Chaotica(CHEBI:"amyloid-beta")complex(GO:"NF-kappaB complex")p(HGNC:IL6)
Chaotica(CHEBI:"amyloid-beta")complex(GO:"NF-kappaB complex")p(HGNC:IL1B)
Chaoticbp(GO:autophagy)p(HGNC:MAPT)p(HGNC:SQSTM1)
Chaoticp(MGI:"interleukin 1 alpha")p(MGI:"oncostatin M")p(MGI:"signal transducer and activator of transcription 3")
Chaoticbp(GO:"MAPK cascade")p(FPLX:NFkappaB)p(HGNC:TNF)
Chaotica(CHEBI:nicotine)p(HGNC:CHRNA7)p(HGNC:JAK2)
Chaotica(CHEBI:nicotine)p(HGNC:CHRNA7)p(HGNC:CHRNA7)
Chaotica(CHEBI:"amyloid-beta polypeptide 42")bp(GO:phagocytosis)p(HGNC:TREM2)
Chaotica(HBP:"Tau oligomers")p(HGNC:MAPT)path(MESH:"Brain Injuries, Traumatic")
Chaoticp(HGNC:MAPT)p(HGNC:MAPT)p(HGNC:SQSTM1)
Chaotica(CHEBI:"amyloid-beta")p(HGNC:APP)p(HGNC:DKK1)
Chaotica(CHEBI:"amyloid-beta")complex(GO:"NF-kappaB complex")complex(GO:"calcium- and calmodulin-dependent protein kinase complex")
Chaotica(CHEBI:acetylcholine)a(CHEBI:nicotine)p(HGNC:CHRNA7)
Chaotica(GO:"neurofibrillary tangle")p(HGNC:GSK3B)p(HGNC:MAPT, pmod(Ph))
Chaotica(CHEBI:"amyloid-beta")p(HGNC:FOLH1)path(MESH:"Alzheimer Disease")
Chaotica(CHEBI:"amyloid-beta")bp(GO:"MAPK cascade")p(HGNC:TNF)
Chaotica(CHEBI:"amyloid-beta")path(MESH:"Alzheimer Disease")r(HGNC:BACE1)
Chaoticp(HGNC:FKBP5)p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
Chaotica(CHEBI:"amyloid-beta")p(FPLX:JNK)p(HGNC:DKK1)
Chaotica(CHEBI:"calcium(2+)")a(MESH:"Receptors, Nicotinic")p(HGNC:CHRNA7)
Chaotica(CHEBI:acetylcholine)bp(GO:"membrane depolarization")p(FPLX:CHRN)
Chaotica(CHEBI:"calcium(2+)")a(CHEBI:acetylcholine)p(HGNC:CHRNA7)
Chaotica(MESH:Neurons)p(HGNC:MAPT)p(HGNC:MAPT)
Chaotica(CHEBI:nicotine)a(MESH:"SNARE Proteins")p(HGNC:CHRNA7)
Chaotica(CHEBI:"calcium(2+)")a(CHEBI:acetylcholine)a(MESH:"Receptors, Nicotinic")
Chaotica(CHEBI:"amyloid-beta")p(HGNC:MAPT)path(MESH:"Alzheimer Disease")
Chaotica(CHEBI:"amyloid-beta")a(CHEBI:acetylcholine)p(HGNC:CHRNA7)
Chaotica(CHEBI:"amyloid-beta")complex(GO:"NF-kappaB complex")p(HGNC:TNF)
Chaotica(CHEBI:"amyloid-beta")complex(GO:"NLRP3 inflammasome complex")p(HGNC:IL18)
Chaotica(CHEBI:"calcium(2+)")a(CHEBI:acetylcholine)p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
Chaotica(CHEBI:"amyloid-beta")p(HGNC:CHRNA7)path(MESH:"Alzheimer Disease")
Chaoticp(HGNC:GSK3B)p(HGNC:MAPT)p(HGNC:MAPT, pmod(Ph, Thr, 205))
Chaotica(HBP:"amyloid-beta aggregates")path(HBP:"mitochondrial dysfunction")path(MESH:"Alzheimer Disease")
Chaotica(CHEBI:"amyloid-beta")p(HGNC:APP)p(HGNC:IL1B)
Chaotica(CHEBI:"amyloid-beta")bp(MESH:"Oxidative Stress")p(HGNC:MAPT)
Chaotica(CHEBI:"amyloid-beta")a(HBP:HBP00038)complex(GO:"NLRP3 inflammasome complex")
Chaotica(CHEBI:"calcium(2+)")a(CHEBI:acetylcholine)p(FPLX:CHRN)
Chaotica(CHEBI:"amyloid-beta")p(FPLX:TLR)p(HGNC:IL1B)
Chaotica(CHEBI:"calcium(2+)")a(CHEBI:nicotine)p(HGNC:CHRNA7)
Chaotica(CHEBI:"reactive oxygen species")complex(GO:"NF-kappaB complex")p(FPLX:PKC)
Chaotica(CHEBI:nicotine)a(MESH:Neurons)p(MGI:Lynx1)
Chaotica(CHEBI:nicotine)a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")bp(GO:"ERK1 and ERK2 cascade")
Chaotica(HBP:"Tau aggregates")p(HGNC:MAPT, frag("?"))path(MESH:Tauopathies)
Chaotica(CHEBI:"amyloid-beta")p(HGNC:BACE1)p(HGNC:RELA)
Chaotica(MESH:Microglia)complex(GO:"NF-kappaB complex")p(HGNC:IL6)
Chaotica(CHEBI:"amyloid-beta")complex(GO:"NLRP1 inflammasome complex")p(HGNC:IL1B)
Chaotica(CHEBI:"amyloid-beta")p(FPLX:NFkappaB)p(HGNC:IL1B)
Chaotica(GO:"neurofibrillary tangle")p(HGNC:GSK3B)p(HGNC:MAPT, pmod(Ph, Thr, 231))
Chaotica(CHEBI:"amyloid-beta")p(HGNC:CASP1)p(HGNC:IL1B)
Chaotica(CHEBI:"calcium(2+)")a(CHEBI:dopamine)a(HBP:HBP00093)
Chaoticp(HGNC:AK1)p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
Chaotica(CHEBI:"amyloid-beta")p(HGNC:BACE1)p(HGNC:SYK)
Chaoticp(HGNC:FYN)p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
Chaotica(HBP:"Tau oligomers")p(HGNC:MAPT)p(HGNC:MAPT)
Chaotica(CHEBI:"amyloid-beta")complex(GO:"NLRP1 inflammasome complex")p(HGNC:IL18)
Chaoticp(HGNC:CDK2)p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
Chaotica(CHEBI:"amyloid-beta")p(HGNC:MAPT)p(HGNC:SYK)
Chaotica(CHEBI:"amyloid-beta")bp(GO:"response to oxidative stress")bp(GO:autophagy)
Chaotica(CHEBI:"amyloid-beta")p(HGNC:CASP1)p(HGNC:IL18)
Chaotica(CHEBI:"amyloid-beta")p(HGNC:APOE)path(MESH:"Alzheimer Disease")
Chaotica(CHEBI:"amyloid-beta")p(HGNC:APP)p(HGNC:WNT3A)
Chaotica(CHEBI:"amyloid-beta")bp(GO:"inflammatory response")p(HGNC:DKK1)
Chaotica(CHEBI:"amyloid-beta")p(HGNC:MAPT, pmod(Ph))path(MESH:"Alzheimer Disease")
Chaoticp(HGNC:GSK3B)p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Chaoticbp(GO:autophagy)bp(MESH:"Unfolded Protein Response")p(MESH:Proteins, pmod(HBP:misfolded))
Chaotica(CHEBI:"amyloid-beta")bp(GO:"Fas signaling pathway")complex(GO:"NF-kappaB complex")
Chaotica(CHEBI:"amyloid-beta")a(MESH:Astrocytes)path(MESH:"Plaque, Amyloid")
Chaotica(CHEBI:"amyloid-beta")a(CHEBI:"reactive oxygen species")complex(GO:"NF-kappaB complex")
Chaotica(MESH:Proteins)a(MESH:Proteins)p(HGNC:PSMD14)
Chaotica(CHEBI:"calcium(2+)")a(CHEBI:acetylcholine)a(CHEBI:choline)
Chaotica(CHEBI:"amyloid-beta")p(HGNC:BACE1)p(HGNC:TNF)
Chaotica(HBP:"Tau aggregates")p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))p(HGNC:SYK)
Chaotica(CHEBI:"amyloid-beta")a(MESH:Microglia)p(HGNC:MAPT)
Chaotica(CHEBI:"amyloid-beta")complex(GO:"NF-kappaB complex")p(HGNC:SYK)
Chaotica(CHEBI:"amyloid-beta")p(HGNC:MAPK14)p(HGNC:RELA)
Chaoticp(FPLX:NFkappaB)p(FPLX:NFkappaB)p(HGNC:TNF)
Chaotica(HBP:"Tau aggregates")p(HGNC:MAPT)p(HGNC:SYK)
Chaoticcomplex(a(GO:microtubule), p(HGNC:MAPT))p(HGNC:MAPT)p(HGNC:MAPT)
Chaotica(CHEBI:"amyloid-beta")p(HGNC:TARDBP)p(HGNC:TFEB)
Chaotica(GO:"neurofibrillary tangle")p(HGNC:GSK3B)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Chaotica(CHEBI:"amyloid-beta")bp(GO:"JNK cascade")complex(GO:"NF-kappaB complex")
Chaotica(CHEBI:"amyloid-beta")a(MESH:Microglia)p(HGNC:IL1B)
Chaotica(CHEBI:"amyloid-beta")a(HBP:HBP00038)bp(GO:phagocytosis)
Chaotica(CHEBI:nicotine)p(FPLX:PI3K)p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
Chaotica(CHEBI:acetylcholine)a(CHEBI:galanthamine)p(HGNC:CHRNA7)
Chaotica(CHEBI:"amyloid-beta")p(HGNC:MTOR)p(HGNC:TARDBP)
Chaoticcomplex(GO:"filamentous actin")p(HGNC:MAPT)p(HGNC:MAPT)
Chaotica(CHEBI:"amyloid-beta")bp(MESH:"Oxidative Stress")path(MESH:"Alzheimer Disease")
Chaotica(CHEBI:"amyloid-beta")a(MESH:Microglia)bp(GO:phagocytosis)
Chaotica(CHEBI:"amyloid-beta")bp(GO:autophagy)p(HGNC:MAPK8)
Chaotica(MESH:"Neurofibrillary Tangles")p(HGNC:MAPT)p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Chaotica(CHEBI:"calcium(2+)")p(HGNC:CHRNA7)p(HGNC:CHRNA7)
Chaotica(HBP:"Tau aggregates")a(HBP:"Tau aggregates")p(MGI:Mapt)
Chaotica(CHEBI:acetylcholine)bp(GO:"membrane depolarization")p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
Chaotica(CHEBI:"calcium(2+)")a(CHEBI:"calcium(2+)")p(HGNC:CHRNA7)
Chaoticp(FPLX:NFkappaB)p(FPLX:NFkappaB)p(HGNC:IL1B)
Chaotica(CHEBI:"amyloid-beta")bp(MESH:"Oxidative Stress")complex(GO:"NF-kappaB complex")
Chaotica(HBP:HBP00093)bp(GO:autophagy)bp(MESH:"Endoplasmic Reticulum Stress")
Chaotica(GO:"neurofibrillary tangle")p(HGNC:MAPT, pmod(Ph))p(HGNC:TNF)
Chaotica(CHEBI:"amyloid-beta")p(HGNC:CHRNA7)p(HGNC:CHRNA7)
Chaotica(CHEBI:"calcium(2+)")p(HGNC:MAPT)p(HGNCGENEFAMILY:Calpains)
Chaoticp(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B")p(MGI:"interleukin 1 alpha")p(MGI:"oncostatin M")
Chaotica(CHEBI:"amyloid-beta")a(CHEBI:"calcium(2+)")p(HGNC:CHRNA7)
Chaotica(CHEBI:"reactive oxygen species")bp(GO:"inflammatory response")complex(GO:"NF-kappaB complex")
Chaoticp(MGI:"interleukin 1 alpha")p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105")p(MGI:"oncostatin M")
Chaotica(CHEBI:"amyloid-beta")a(CHEBI:simvastatin)a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")
Chaoticp(HGNC:RNF19A)p(HGNC:SOD1, var("?"))path(MESH:"Amyotrophic Lateral Sclerosis")
Chaotica(CHEBI:"amyloid-beta")p(HGNC:IL1B)p(HGNC:NFKB1)
Chaotica(CHEBI:"amyloid-beta")complex(GO:"NLRP3 inflammasome complex")p(HGNC:IL1B)
Chaotica(CHEBI:"reactive oxygen species")bp(GO:"inflammatory response")p(FPLX:NFkappaB)
Chaotica(CHEBI:"amyloid-beta")p(HGNC:BACE1)path(MESH:"Alzheimer Disease")
Chaotica(CHEBI:"amyloid-beta")bp(GO:"innate immune response")complex(GO:"NLRP3 inflammasome complex")
Chaotica(CHEBI:"amyloid-beta")complex(GO:"NF-kappaB complex")complex(a(GO:"membrane attack complex"), p(HGNC:C5))
Chaoticbp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")p(HGNC:MAPT)p(HGNC:SQSTM1)
Chaotica(GO:autophagosome)a(MESH:Proteins)bp(GO:autophagy)
Dampeneda(CHEBI:methamphetamine)bp(GO:autophagy)p(HGNC:DRD1)
Dampeneda(HBP:"Tau aggregates")complex(a(GO:microtubule), p(HGNC:MAPT))p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
Dampeneda(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:CHRM1)
Dampeneda(CHEBI:"amyloid-beta")complex(GO:"NF-kappaB complex")p(HGNC:BCL2L1)
Dampeneda(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:CHRNA7)
Dampeneda(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")a(CHEBI:nicotine)
Dampenedp(HBP:"cis p-tau")p(HBP:"cis p-tau")p(HGNC:PIN1)
Dampeneda(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")complex(p(FPLX:"G_protein"), p(HGNC:CHRM1))
Dampeneda(CHEBI:"amyloid-beta")a(CHEBI:"amyloid-beta")p(HGNC:BCL2L1)
+ -

- Causal Pathologies - 396 -

-

- Pathologies are more dogmatically the result of molecular and physical processes, - and do not necessarily make sense as the subject of causal statements. -

- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
SourceRelationTarget
path(HBP:"Chronic cerebral hypoperfusion")increasesp(FPLX:NFkappaB)
path(HBP:"Chronic cerebral hypoperfusion")increasesp(HBP:"CDK5R1 p25")
path(HBP:"Chronic cerebral hypoperfusion")increasesp(RGD:Mapt, pmod(Ph, Ser, 202))
path(HBP:"Chronic cerebral hypoperfusion")increasesp(RGD:Mapt, pmod(Ph, Ser, 262))
path(HBP:"Chronic cerebral hypoperfusion")increasesp(RGD:Mapt, pmod(Ph, Ser, 422))
path(HBP:"Chronic cerebral hypoperfusion")increasesp(RGD:Mapt, pmod(Ph, Thr, 205))
path(HBP:"Chronic cerebral hypoperfusion")increasesp(RGD:Mapt, pmod(Ph, Thr, 231))
path(HBP:"high-fat prenatal maternal diet")decreasesa(CHEBI:"amyloid-beta")
path(HBP:"isolation rearing")increasesp(RGD:Drd2)
path(HBP:"isolation rearing")increasesp(RGD:Drd3)
path(HBP:"isolation rearing")decreasesr(RGD:Bdnf)
path(HBP:"isolation rearing")increasesr(RGD:Bdnf)
path(HBP:"isolation rearing")decreasesr(RGD:Ntrk2)
path(HBP:"isolation rearing")increasesr(RGD:Ntrk2)
path(HBP:"mitochondrial dysfunction")increasesa(CHEBI:"amyloid-beta")
path(HBP:"mitochondrial dysfunction")increasesa(CHEBI:"reactive oxygen species")
path(HBP:"mitochondrial dysfunction")decreasesa(CHEBI:ATP)
path(HBP:"mitochondrial dysfunction")increasescomplex(GO:"cytoplasmic stress granule")
path(HBP:"mitochondrial dysfunction")increasesp(HGNC:MAPT)
path(HBP:"peripheral nervous system injury")increasesp(FPLX:ERK)
path(HBP:Excitotoxicity)increasesa(CHEBI:"calcium(2+)")
path(HP:"Ischemic stroke")increasescomplex(GO:"NF-kappaB complex")
path(HP:"Neurofibrillary tangles")decreasesp(FPLX:Proteasome)
path(HP:"Senile plaques")increasesa(HBP:"amyloid-beta aggregates")
path(HP:"Senile plaques")increasesa(MESH:"Neurofibrillary Tangles")
path(HP:Seizures)increasescomplex(GO:"NF-kappaB complex")
path(MESH:"Alcohol Drinking")decreasesp(HGNC:ADNP)
path(MESH:"Alcohol Drinking")increasesp(HGNC:ADNP)
path(MESH:"Alcohol Drinking")decreasesp(HGNC:TFAP2B)
path(MESH:"Alcohol Drinking")increasesr(HGNC:ADNP)
path(MESH:"Alzheimer Disease")decreasesa(CHEBI:"amyloid-beta")
path(MESH:"Alzheimer Disease")increasesa(CHEBI:"amyloid-beta")
path(MESH:"Alzheimer Disease")increasesa(CHEBI:"iron(0)")
path(MESH:"Alzheimer Disease")increasesa(CHEBI:Thrombin)
path(MESH:"Alzheimer Disease")decreasesa(CHEBI:acetylcholine)
path(MESH:"Alzheimer Disease")decreasesa(CHEBI:water)
path(MESH:"Alzheimer Disease")increasesa(GO:autolysosome)
path(MESH:"Alzheimer Disease")increasesa(GO:autophagosome)
path(MESH:"Alzheimer Disease")increasesa(GO:lysosome)
path(MESH:"Alzheimer Disease")increasesa(HBP:"Tau oligomers")
path(MESH:"Alzheimer Disease")decreasesa(HBP:"alpha-4 beta-2 nAChR")
path(MESH:"Alzheimer Disease")increasesa(HBP:"amyloid-beta aggregates")
path(MESH:"Alzheimer Disease")increasesa(HBP:HBP00018)
path(MESH:"Alzheimer Disease")increasesa(MESH:"Basal Nucleus of Meynert")
path(MESH:"Alzheimer Disease")decreasesa(MESH:"Cholinergic Neurons")
path(MESH:"Alzheimer Disease")decreasesa(MESH:"Cholinesterase Inhibitors")
path(MESH:"Alzheimer Disease")increasesa(MESH:"Neurofibrillary Tangles")
path(MESH:"Alzheimer Disease")increasesa(MESH:Autophagosomes)
path(MESH:"Alzheimer Disease")decreasesa(MESH:Neurons)
path(MESH:"Alzheimer Disease")decreasescomplex(a(CHEBI:acetylcholine), p(FPLX:CHRM))
path(MESH:"Alzheimer Disease")decreasescomplex(a(CHEBI:acetylcholine), p(FPLX:CHRN))
path(MESH:"Alzheimer Disease")decreasescomplex(a(CHEBI:nicotine), p(FPLX:CHRM))
path(MESH:"Alzheimer Disease")decreasescomplex(a(CHEBI:nicotine), p(FPLX:CHRN))
path(MESH:"Alzheimer Disease")increasescomplex(a(GO:autophagosome), a(HBP:"dystrophic neurite"))
path(MESH:"Alzheimer Disease")decreasescomplex(a(GO:microtubule), p(HGNC:MAPT))
path(MESH:"Alzheimer Disease")decreasescomplex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))
path(MESH:"Alzheimer Disease")increasescomplex(p(HGNC:ESR1), p(HGNC:MAPT))
path(MESH:"Alzheimer Disease")increasescomplex(p(HGNC:FYN), p(HGNC:MAPT))
path(MESH:"Alzheimer Disease")increasescomplex(p(HGNC:MAPT), p(HGNCGENEFAMILY:Proteasome))
path(MESH:"Alzheimer Disease")decreasesg(HGNC:"MIR9-1")
path(MESH:"Alzheimer Disease")decreasesp(FPLX:CHRM)
path(MESH:"Alzheimer Disease")decreasesp(FPLX:CHRN)
path(MESH:"Alzheimer Disease")increasesp(FPLX:HSPB)
path(MESH:"Alzheimer Disease")decreasesp(FPLX:PPP2)
path(MESH:"Alzheimer Disease")decreasesp(FPLX:PPP2, pmod(Me))
path(MESH:"Alzheimer Disease")decreasesp(HBP:"alpha-4 beta-2 nAChR")
path(MESH:"Alzheimer Disease")increasesp(HBP:"phosphatase-activating domain")
path(MESH:"Alzheimer Disease")decreasesp(HGNC:ABCB1)
path(MESH:"Alzheimer Disease")increasesp(HGNC:ABL1)
path(MESH:"Alzheimer Disease")decreasesp(HGNC:ACHE)
path(MESH:"Alzheimer Disease")decreasesp(HGNC:ACLY)
path(MESH:"Alzheimer Disease")increasesp(HGNC:AGRN)
path(MESH:"Alzheimer Disease")increasesp(HGNC:AK1)
path(MESH:"Alzheimer Disease")increasesp(HGNC:ANP32A)
path(MESH:"Alzheimer Disease")decreasesp(HGNC:ATAD2)
path(MESH:"Alzheimer Disease")increasesp(HGNC:ATP1A1)
path(MESH:"Alzheimer Disease")increasesp(HGNC:BACE1)
path(MESH:"Alzheimer Disease")increasesp(HGNC:BAX)
path(MESH:"Alzheimer Disease")increasesp(HGNC:BCHE)
path(MESH:"Alzheimer Disease")decreasesp(HGNC:BECN1)
path(MESH:"Alzheimer Disease")increasesp(HGNC:BGN)
path(MESH:"Alzheimer Disease")increasesp(HGNC:BRCA1)
path(MESH:"Alzheimer Disease")increasesp(HGNC:CADPS2)
path(MESH:"Alzheimer Disease")decreasesp(HGNC:CANX)
path(MESH:"Alzheimer Disease")increasesp(HGNC:CAPN1)
path(MESH:"Alzheimer Disease")increasesp(HGNC:CAPN2)
path(MESH:"Alzheimer Disease")increasesp(HGNC:CCNB1)
path(MESH:"Alzheimer Disease")increasesp(HGNC:CDK1)
path(MESH:"Alzheimer Disease")increasesp(HGNC:CDK2)
path(MESH:"Alzheimer Disease")increasesp(HGNC:CDKN2A)
path(MESH:"Alzheimer Disease")decreasesp(HGNC:CHAT)
path(MESH:"Alzheimer Disease")decreasesp(HGNC:CHRNA3)
path(MESH:"Alzheimer Disease")decreasesp(HGNC:CHRNA4)
path(MESH:"Alzheimer Disease")decreasesp(HGNC:CHRNA7)
path(MESH:"Alzheimer Disease")increasesp(HGNC:CHRNA7)
path(MESH:"Alzheimer Disease")decreasesp(HGNC:CHRNB4)
path(MESH:"Alzheimer Disease")increasesp(HGNC:CRYAB)
path(MESH:"Alzheimer Disease")increasesp(HGNC:CTSD)
path(MESH:"Alzheimer Disease")increasesp(HGNC:CXCR4)
path(MESH:"Alzheimer Disease")decreasesp(HGNC:DHCR24)
path(MESH:"Alzheimer Disease")increasesp(HGNC:EIF4EBP1)
path(MESH:"Alzheimer Disease")decreasesp(HGNC:FGF2)
path(MESH:"Alzheimer Disease")decreasesp(HGNC:FKBP4)
path(MESH:"Alzheimer Disease")increasesp(HGNC:FKBP5)
path(MESH:"Alzheimer Disease")increasesp(HGNC:FOLH1)
path(MESH:"Alzheimer Disease")increasesp(HGNC:FYN)
path(MESH:"Alzheimer Disease")decreasesp(HGNC:GABRB3)
path(MESH:"Alzheimer Disease")decreasesp(HGNC:GCNT2)
path(MESH:"Alzheimer Disease")increasesp(HGNC:GLRX)
path(MESH:"Alzheimer Disease")increasesp(HGNC:HMOX1)
path(MESH:"Alzheimer Disease")increasesp(HGNC:HOMER1)
path(MESH:"Alzheimer Disease")increasesp(HGNC:HRH1)
path(MESH:"Alzheimer Disease")decreasesp(HGNC:HSP90AB1)
path(MESH:"Alzheimer Disease")decreasesp(HGNC:HSPA14)
path(MESH:"Alzheimer Disease")decreasesp(HGNC:HSPA8)
path(MESH:"Alzheimer Disease")increasesp(HGNC:HSPB1)
path(MESH:"Alzheimer Disease")decreasesp(HGNC:HTRA1)
path(MESH:"Alzheimer Disease")decreasesp(HGNC:IDE)
path(MESH:"Alzheimer Disease")increasesp(HGNC:IGF2)
path(MESH:"Alzheimer Disease")increasesp(HGNC:IGFBP2)
path(MESH:"Alzheimer Disease")increasesp(HGNC:IL6R)
path(MESH:"Alzheimer Disease")increasesp(HGNC:ITPKB)
path(MESH:"Alzheimer Disease")decreasesp(HGNC:LCMT1)
path(MESH:"Alzheimer Disease")increasesp(HGNC:LDLR)
path(MESH:"Alzheimer Disease")increasesp(HGNC:MAOA)
path(MESH:"Alzheimer Disease")increasesp(HGNC:MAPK1)
path(MESH:"Alzheimer Disease")increasesp(HGNC:MAPT)
path(MESH:"Alzheimer Disease")increasesp(HGNC:MAPT, frag("?"))
path(MESH:"Alzheimer Disease")decreasesp(HGNC:MAPT, pmod(Ac, Lys, 259))
path(MESH:"Alzheimer Disease")decreasesp(HGNC:MAPT, pmod(Ac, Lys, 290))
path(MESH:"Alzheimer Disease")decreasesp(HGNC:MAPT, pmod(Ac, Lys, 321))
path(MESH:"Alzheimer Disease")decreasesp(HGNC:MAPT, pmod(Ac, Lys, 353))
path(MESH:"Alzheimer Disease")decreasesp(HGNC:MAPT, pmod(HBP:misfolded))
path(MESH:"Alzheimer Disease")decreasesp(HGNC:MAPT, pmod(OGlyco))
path(MESH:"Alzheimer Disease")increasesp(HGNC:MAPT, pmod(Ph))
path(MESH:"Alzheimer Disease")regulatesp(HGNC:MAPT, pmod(Ph))
path(MESH:"Alzheimer Disease")increasesp(HGNC:MAPT, pmod(Ph, Thr, 231))
path(MESH:"Alzheimer Disease")decreasesp(HGNC:MME)
path(MESH:"Alzheimer Disease")decreasesp(HGNC:MMP1)
path(MESH:"Alzheimer Disease")increasesp(HGNC:NEFH)
path(MESH:"Alzheimer Disease")decreasesp(HGNC:NFE2L2)
path(MESH:"Alzheimer Disease")increasesp(HGNC:NPDC1)
path(MESH:"Alzheimer Disease")increasesp(HGNC:NPTX1)
path(MESH:"Alzheimer Disease")increasesp(HGNC:NQO1)
path(MESH:"Alzheimer Disease")decreasesp(HGNC:NR3C1)
path(MESH:"Alzheimer Disease")increasesp(HGNC:NRGN)
path(MESH:"Alzheimer Disease")decreasesp(HGNC:OGT)
path(MESH:"Alzheimer Disease")increasesp(HGNC:PHF1)
path(MESH:"Alzheimer Disease")decreasesp(HGNC:PPARA)
path(MESH:"Alzheimer Disease")decreasesp(HGNC:PPID)
path(MESH:"Alzheimer Disease")increasesp(HGNC:PPME1)
path(MESH:"Alzheimer Disease")decreasesp(HGNC:PPP5C)
path(MESH:"Alzheimer Disease")increasesp(HGNC:PREP)
path(MESH:"Alzheimer Disease")increasesp(HGNC:PRKCB)
path(MESH:"Alzheimer Disease")increasesp(HGNC:PRKCD)
path(MESH:"Alzheimer Disease")decreasesp(HGNC:PRKCE)
path(MESH:"Alzheimer Disease")decreasesp(HGNC:PRKDC)
path(MESH:"Alzheimer Disease")increasesp(HGNC:PROS1)
path(MESH:"Alzheimer Disease")increasesp(HGNC:PTGS1)
path(MESH:"Alzheimer Disease")increasesp(HGNC:PTGS2)
path(MESH:"Alzheimer Disease")increasesp(HGNC:RANBP9)
path(MESH:"Alzheimer Disease")decreasesp(HGNC:SCD)
path(MESH:"Alzheimer Disease")increasesp(HGNC:SELENBP1)
path(MESH:"Alzheimer Disease")increasesp(HGNC:SET)
path(MESH:"Alzheimer Disease")decreasesp(HGNC:SIRT1)
path(MESH:"Alzheimer Disease")decreasesp(HGNC:SLC6A6)
path(MESH:"Alzheimer Disease")increasesp(HGNC:SOD1)
path(MESH:"Alzheimer Disease")decreasesp(HGNC:SYVN1)
path(MESH:"Alzheimer Disease")increasesp(HGNC:TAGLN)
path(MESH:"Alzheimer Disease")decreasesp(HGNC:TCP1)
path(MESH:"Alzheimer Disease")increasesp(HGNC:TGFB1)
path(MESH:"Alzheimer Disease")decreasesp(HGNC:TSHZ1)
path(MESH:"Alzheimer Disease")decreasesp(HGNC:TUBB)
path(MESH:"Alzheimer Disease")increasesp(HGNC:TUBB3)
path(MESH:"Alzheimer Disease")decreasesp(HGNC:TXN)
path(MESH:"Alzheimer Disease")decreasesp(HGNC:UNG)
path(MESH:"Alzheimer Disease")increasesp(HGNC:VKORC1)
path(MESH:"Alzheimer Disease")decreasesp(HGNCGENEFAMILY:"Cholinergic receptors muscarinic")
path(MESH:"Alzheimer Disease")decreasesp(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
path(MESH:"Alzheimer Disease")increasesp(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
path(MESH:"Alzheimer Disease")decreasesp(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins")
path(MESH:"Alzheimer Disease")decreasesp(HGNCGENEFAMILY:"Glutamate ionotropic receptor AMPA type subunits")
path(MESH:"Alzheimer Disease")decreasesp(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits")
path(MESH:"Alzheimer Disease")increasesp(HGNCGENEFAMILY:Transglutaminases)
path(MESH:"Alzheimer Disease")increasesp(MESH:"Presenilin-1")
path(MESH:"Alzheimer Disease")increasesp(MGI:Il6)
path(MESH:"Alzheimer Disease")increasesp(MGI:Stat3, pmod(Ph))
path(MESH:"Alzheimer Disease")increasesp(MGI:Tnf)
path(MESH:"Alzheimer Disease")increasesr(HGNC:GSK3B)
path(MESH:"Amyotrophic Lateral Sclerosis")decreasesa(MESH:"Brain Stem")
path(MESH:"Amyotrophic Lateral Sclerosis")decreasesa(MESH:"Pyramidal Tracts")
path(MESH:"Amyotrophic Lateral Sclerosis")increasesp(HGNC:RNF19A)
path(MESH:"Brain Injuries, Traumatic")decreasesa(HP:"glymphatic system")
path(MESH:"Brain Injuries, Traumatic")increasescomplex(GO:"NF-kappaB complex")
path(MESH:"Brain Injuries, Traumatic")decreasesp(HGNC:AQP4)
path(MESH:"Brain Injuries, Traumatic")increasesp(HGNC:MAPT)
path(MESH:"Breast Neoplasms")increasesp(HGNC:CHRNA10)
path(MESH:"Breast Neoplasms")increasesp(HGNC:CHRNA5)
path(MESH:"Breast Neoplasms")increasesp(HGNC:CHRNA9)
path(MESH:"Calcification, Physiologic")decreasesa(MESH:"Cerebrospinal Fluid")
path(MESH:"Cerebral Infarction")increasescomplex(GO:"NF-kappaB complex")
path(MESH:"Colorectal Neoplasms")decreasesp(HGNC:ABCD3)
path(MESH:"Colorectal Neoplasms")increasesp(HGNC:ACLY)
path(MESH:"Colorectal Neoplasms")increasesp(HGNC:ANTXR1)
path(MESH:"Colorectal Neoplasms")increasesp(HGNC:C20orf27)
path(MESH:"Colorectal Neoplasms")increasesp(HGNC:CCNA2)
path(MESH:"Colorectal Neoplasms")increasesp(HGNC:CHAF1A)
path(MESH:"Colorectal Neoplasms")increasesp(HGNC:DHFR)
path(MESH:"Colorectal Neoplasms")increasesp(HGNC:EFCAB11)
path(MESH:"Colorectal Neoplasms")increasesp(HGNC:FEN1)
path(MESH:"Colorectal Neoplasms")increasesp(HGNC:GINS2)
path(MESH:"Colorectal Neoplasms")increasesp(HGNC:GLRX2)
path(MESH:"Colorectal Neoplasms")increasesp(HGNC:MCM10)
path(MESH:"Colorectal Neoplasms")increasesp(HGNC:MCM4)
path(MESH:"Colorectal Neoplasms")increasesp(HGNC:MICB)
path(MESH:"Colorectal Neoplasms")increasesp(HGNC:NQO1)
path(MESH:"Colorectal Neoplasms")increasesp(HGNC:RNASEH2A)
path(MESH:"Colorectal Neoplasms")increasesp(HGNC:SLIT2)
path(MESH:"Colorectal Neoplasms")increasesp(HGNC:SPC25)
path(MESH:"Colorectal Neoplasms")increasesp(HGNC:TFRC)
path(MESH:"Colorectal Neoplasms")increasesp(HGNC:TK1)
path(MESH:"Colorectal Neoplasms")increasesp(HGNC:TMEM97)
path(MESH:"Colorectal Neoplasms")increasesp(HGNC:TRIP13)
path(MESH:"Colorectal Neoplasms")increasesp(HGNC:TUBB)
path(MESH:"Colorectal Neoplasms")increasesp(HGNC:TUBB3)
path(MESH:"Colorectal Neoplasms")increasesp(HGNC:TYMS)
path(MESH:"Colorectal Neoplasms")increasesp(HGNC:UBA1)
path(MESH:"Colorectal Neoplasms")increasesp(HGNC:UNG)
path(MESH:"Colorectal Neoplasms")increasesp(HGNC:VRK1)
path(MESH:"Down Syndrome")increasesa(HBP:HBP00018)
path(MESH:"Frontotemporal Dementia")increasesp(HGNC:ABL1)
path(MESH:"Frontotemporal Dementia")increasesp(HGNC:CTSD)
path(MESH:"Frontotemporal Dementia")increasesp(HGNC:LAMP1)
path(MESH:"Frontotemporal Dementia")increasesp(HGNC:TFEB)
path(MESH:"Frontotemporal Dementia")increasesr(HGNC:LAMP1)
path(MESH:"Frontotemporal Dementia")increasesr(HGNC:TFEB)
path(MESH:"Huntington Disease")increasesg(HGNC:MIR1247)
path(MESH:"Huntington Disease")increasesg(HGNC:MIR196A1)
path(MESH:"Huntington Disease")increasesg(HGNC:MIR196B)
path(MESH:"Huntington Disease")increasesg(HGNC:MIR615)
path(MESH:"Huntington Disease")decreasesg(MGI:"Mir128-1")
path(MESH:"Huntington Disease")decreasesg(MGI:"Mir138-1")
path(MESH:"Huntington Disease")decreasesg(MGI:"Mir218-1")
path(MESH:"Huntington Disease")decreasesg(MGI:Mir132)
path(MESH:"Huntington Disease")decreasesg(MGI:Mir22)
path(MESH:"Huntington Disease")decreasesg(MGI:Mir222)
path(MESH:"Huntington Disease")decreasesg(MGI:Mir29c)
path(MESH:"Huntington Disease")increasesg(MIRBASE:"hsa-mir-10b")
path(MESH:"Huntington Disease")decreasesg(NCBIGENE:406915)
path(MESH:"Huntington Disease")decreasesg(NCBIGENE:723931)
path(MESH:"Huntington Disease")decreasesg(NCBIGENE:732489)
path(MESH:"Huntington Disease")increasesp(HGNC:CTSD)
path(MESH:"Huntington Disease")decreasesp(HGNC:HSP90AB1)
path(MESH:"Huntington Disease")decreasesp(HGNC:HSPA14)
path(MESH:"Huntington Disease")decreasesp(HGNC:HSPA8)
path(MESH:"Huntington Disease")decreasesp(HGNC:TCP1)
path(MESH:"Lung Neoplasms")increasesp(HGNC:CHRNA10)
path(MESH:"Lung Neoplasms")increasesp(HGNC:CHRNA5)
path(MESH:"Lung Neoplasms")increasesp(HGNC:CHRNA9)
path(MESH:"Parkinson Disease")increasesa(CHEBI:"iron(0)")
path(MESH:"Parkinson Disease")decreasesa(MESH:"Dopaminergic Neurons")
path(MESH:"Parkinson Disease")decreasesg(HGNC:MIR205)
path(MESH:"Parkinson Disease")decreasesg(HGNC:MIR34B)
path(MESH:"Parkinson Disease")decreasesg(HGNC:MIR34C)
path(MESH:"Parkinson Disease")increasesg(HGNC:MIR494)
path(MESH:"Parkinson Disease")decreasesp(HGNC:PARK7)
path(MESH:"Plaque, Amyloid")increasesa(MESH:Astrocytes)
path(MESH:"Prion Diseases")increasesa(HBP:"amyloid-beta aggregates")
path(MESH:"Prion Diseases")increasesp(MESH:Proteins, pmod(HBP:misfolded))
path(MESH:"Protein Aggregation, Pathological")decreasesp(HGNC:HSPA8)
path(MESH:"Proteostasis Deficiencies")decreasesp(MGI:Mapt, var("p.Pro301Leu"))
path(MESH:"RING Finger Domains")increasescomplex(a(MESH:Ubiquitin), p(HGNC:UBA2))
path(MESH:"Spinal Cord Injuries")increasesa(CHEBI:ATP)
path(MESH:"Spinal Cord Injuries")increasescomplex(GO:"NLRP1 inflammasome complex")
path(MESH:"Spinal Cord Injuries")increasesp(HGNC:IL18)
path(MESH:"Spinal Cord Injuries")increasesp(HGNC:IL1B)
path(MESH:"Stress Disorders, Traumatic")increasesr(MESH:"corticotropin releasing factor-binding protein")
path(MESH:"Supranuclear Palsy, Progressive")increasesa(GO:"neurofibrillary tangle")
path(MESH:"Supranuclear Palsy, Progressive")increasesa(HBP:HBP00045)
path(MESH:"Supranuclear Palsy, Progressive")decreasesp(FPLX:PPP2, pmod(Me))
path(MESH:"Supranuclear Palsy, Progressive")increasesp(HBP:"TGM2 Isoform 3 (349 aa)")
path(MESH:"Supranuclear Palsy, Progressive")decreasesp(HGNC:LCMT1)
path(MESH:"Supranuclear Palsy, Progressive")increasesp(HGNC:PPME1)
path(MESH:"Supranuclear Palsy, Progressive")increasesp(HGNC:TGM1)
path(MESH:"Supranuclear Palsy, Progressive")increasesr(HGNC:TGM1)
path(MESH:"Supranuclear Palsy, Progressive")increasesr(HGNC:TGM2)
path(MESH:"Thyroiditis, Autoimmune")increasesp(HGNC:IL1R2)
path(MESH:"Tobacco Use Disorder")increasesa(HBP:"alpha-4 beta-2 nAChR")
path(MESH:"Trauma, Nervous System")increasescomplex(GO:"inflammasome complex")
path(MESH:"Trauma, Nervous System")increasesr(HGNC:CHRNA3)
path(MESH:"Vitamin B Deficiency")decreasesp(FPLX:PPP2, pmod(Me))
path(MESH:"Vitamin B Deficiency")increasesp(HGNC:APP, pmod(Ph))
path(MESH:"Vitamin B Deficiency")increasesp(HGNC:MAPT, pmod(Ph))
path(MESH:Aging)increasesa(GO:"cytoplasmic vesicle")
path(MESH:Aging)decreasesp(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")
path(MESH:Aging)increasesp(MESH:"Membrane Transport Proteins")
path(MESH:Aging)decreasesp(MESH:"Mitogen-Activated Protein Kinases")
path(MESH:Aging)decreasesp(MGI:Chrna4)
path(MESH:Aging)increasesp(MGI:Hif1an)
path(MESH:Aging)increasesp(MGI:Nfkb1)
path(MESH:Atherosclerosis)increasesp(HGNC:CTNNB1)
path(MESH:Atherosclerosis)increasesp(HGNC:DHFR)
path(MESH:Atherosclerosis)increasesp(HGNC:EDN1)
path(MESH:Atherosclerosis)increasesp(HGNC:EGR1)
path(MESH:Atherosclerosis)increasesp(HGNC:ITGB3)
path(MESH:Atherosclerosis)increasesp(HGNC:MKI67)
path(MESH:Atherosclerosis)increasesp(HGNC:MMP11)
path(MESH:Atherosclerosis)increasesp(HGNC:MMP14)
path(MESH:Atherosclerosis)increasesp(HGNC:MMP2)
path(MESH:Atherosclerosis)decreasesp(HGNC:NR3C1)
path(MESH:Atherosclerosis)increasesp(HGNC:PDE7A)
path(MESH:Atherosclerosis)increasesp(HGNC:PDE7B)
path(MESH:Atherosclerosis)increasesp(HGNC:PLAU)
path(MESH:Atherosclerosis)decreasesp(HGNC:PPARA)
path(MESH:Atherosclerosis)increasesp(HGNC:PTGS1)
path(MESH:Atherosclerosis)increasesp(HGNC:PTGS2)
path(MESH:Atherosclerosis)increasesp(HGNC:SCARB1)
path(MESH:Atherosclerosis)increasesp(HGNC:SOAT1)
path(MESH:Atherosclerosis)increasesp(HGNC:TUBB3)
path(MESH:D000544)decreasesa(HBP:"3R tau")
path(MESH:D000544)decreasesa(MESH:D059329)
path(MESH:D000544)decreasescomplex(a(CHEBI:"magnesium(2+)"), p(HGNCGENEFAMILY:"Glutamate ionotropic receptor NMDA type subunits"))
path(MESH:D000544)increasesg(HGNC:NGFR)
path(MESH:D000544)decreasesg(HGNC:NTRK1)
path(MESH:D000544)decreasesg(HGNC:NTRK2)
path(MESH:D000544)decreasesg(HGNC:NTRK3)
path(MESH:D000544)decreasesp(HGNC:ACHE)
path(MESH:D000544)increasesp(HGNC:BCHE)
path(MESH:D000544)decreasesp(HGNC:CHAT)
path(MESH:D000544)increasesp(HGNC:MMP9)
path(MESH:D000544)increasesp(HGNC:NGF)
path(MESH:D000544)decreasesp(HGNC:NTRK1)
path(MESH:D000544)increasesr(HGNC:CHRNA7)
path(MESH:D000544)increasesr(HGNC:CTSD)
path(MESH:D000544)decreasesr(HGNC:PPP1CA)
path(MESH:D000544)decreasesr(HGNC:PPP1CC)
path(MESH:D000544)decreasesr(HGNC:SYP)
path(MESH:D003704)decreasesp(HGNC:ACHE)
path(MESH:D060825)decreasesa(HBP:"3R tau")
path(MESH:D060825)decreasesa(MESH:D013569)
path(MESH:D060825)increasesp(HGNC:CHAT)
path(MESH:D060825)increasesp(HGNC:MMP9)
path(MESH:Depression)increasesa(CHEBI:choline)
path(MESH:Encephalomyelitis)decreasesa(GO:"myelin sheath")
path(MESH:Encephalomyelitis)increasesa(MESH:Leukocytes)
path(MESH:Encephalomyelitis)increasesa(MESH:Microglia)
path(MESH:Encephalomyelitis)increasesp(MGI:Ifng)
path(MESH:Encephalomyelitis)increasesp(MGI:Il1b)
path(MESH:Encephalomyelitis)increasesp(MGI:Rela, pmod(Ph))
path(MESH:Encephalomyelitis)increasesp(MGI:Stat3, pmod(Ph))
path(MESH:Encephalomyelitis)increasesp(MGI:Tnf)
path(MESH:Fasting)decreasesp(MGI:Mapt, pmod(HBP:"O-GlcNAcylation"))
path(MESH:Fasting)increasesp(MGI:Mapt, pmod(HBP:hyperphosphorylation))
path(MESH:Fear)increasesa(CHEBI:dopamine)
path(MESH:Fibrosis)decreasesa(MESH:"Cerebrospinal Fluid")
path(MESH:Glioblastoma)increasesp(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B")
path(MESH:Glioblastoma)increasesp(MGI:"chitinase-like 1")
path(MESH:Hyperglycemia)increasesp(MESH:Proteins, pmod(HBP:"O-GlcNAcylation"))
path(MESH:Hypoxia)increasescomplex(GO:"NF-kappaB complex")
path(MESH:Hypoxia)increasesp(HGNC:PRKAA1)
path(MESH:Inflammation)decreasesa(CHEBI:"amyloid-beta")
path(MESH:Inflammation)increasesp(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
path(MESH:Inflammation)increasesp(HGNCGENEFAMILY:Caspases)
path(MESH:Neoplasms)increasesp(HGNCGENEFAMILY:"Small heat shock proteins")
path(MESH:Schizophrenia)increasesa(CHEBI:dopamine)
path(MESH:Schizophrenia)decreasesa(GO:dendrite)
path(MESH:Schizophrenia)increasesa(MESH:Hippocampus)
path(MESH:Schizophrenia)decreasesp(FPLX:AKT)
path(MESH:Schizophrenia)decreasesp(HGNC:ADNP)
path(MESH:Schizophrenia)decreasesp(HGNC:ADNP2)
path(MESH:Schizophrenia)decreasesp(HGNC:ATG3)
path(MESH:Schizophrenia)decreasesp(HGNC:BECN1)
path(MESH:Schizophrenia)decreasesp(HGNC:CHRNA7)
path(MESH:Schizophrenia)decreasesp(HGNC:MAP2)
path(MESH:Schizophrenia)increasesp(HGNC:MAPT)
path(MESH:Schizophrenia)decreasesp(HGNC:SLC6A3)
path(MESH:Schizophrenia)decreasesp(HGNC:ULK2)
path(MESH:Sleep)decreasesa(CHEBI:"amyloid-beta")
path(MESH:Sleep)increasesa(MESH:"Blood-Brain Barrier")
path(MESH:Sleep)increasesp(HGNC:LRP1)
path(MESH:Smoking)increasesa(MESH:"Blood Glucose")
path(MESH:Starvation)decreasesa(GO:autolysosome)
path(MESH:Starvation)increasesa(GO:autophagosome)
path(MESH:Starvation)increasescomplex(p(HGNC:TFEB), p(INTERPRO:"cAMP response element binding (CREB) protein"))
path(MESH:Starvation)increasesp(HGNC:MAPT)
path(MESH:Starvation)decreasesp(HGNC:MTOR)
path(MESH:Starvation)increasesp(HGNC:PRKAA1)
path(MESH:Starvation)decreasesp(HGNC:RPS6KB1, pmod(Ph, Thr, 389))
path(MESH:Starvation)increasesp(HGNC:TFEB)
path(MESH:Starvation)increasesp(HGNC:WDFY3)
path(MESH:Starvation)increasesrxn(reactants(a(CHEBI:lipid)), products(a(CHEBI:"fatty acid")))
path(MESH:Stroke)increasescomplex(GO:"inflammasome complex")
path(MESH:Tauopathies)increasesp(HGNC:MAPT, frag("?"))
path(MESH:Tauopathies)increasesp(MGI:Ctsd)
path(MESH:Tauopathies)increasesp(MGI:Lamp1)
path(MESH:Tauopathies)increasesp(MGI:Tfeb)
+ + +
@@ -182296,19 +264232,25 @@

+ - - - - - + + + + - - - + + + - - + + - +