diff --git a/src/ndv/viewer/_viewer.py b/src/ndv/viewer/_viewer.py
index 470fb8e7..1124c1be 100644
--- a/src/ndv/viewer/_viewer.py
+++ b/src/ndv/viewer/_viewer.py
@@ -421,6 +421,11 @@ def set_current_index(self, index: Indices | None = None) -> None:
     def _toggle_3d(self) -> None:
         self.set_ndim(3 if self._ndims == 2 else 2)
 
+        # Disable ROIs in 3D (for now)
+        self._add_roi_btn.setEnabled(self._ndims == 2)
+        if self._roi is not None:
+            self._roi.visible = self._ndims == 2
+
     def _update_slider_ranges(self) -> None:
         """Set the maximum values of the sliders.
 
@@ -625,4 +630,4 @@ def new_key_press(event: QMouseEvent) -> None:
             # Proceed with normal mouse release
             return old_method(event)
 
-        return new_key_press
\ No newline at end of file
+        return new_key_press