diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index 1361980565d..50ec976afce 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -91,7 +91,7 @@ jobs:
       - run: git diff --exit-code
 
   tests-unix:
-    name: tests / ${{ matrix.python }} / ${{ matrix.os }}
+    name: tests / ${{ matrix.python.key || matrix.python }} / ${{ matrix.os }}
     runs-on: ${{ matrix.os }}-latest
 
     needs: [packaging, determine-changes]
@@ -109,12 +109,14 @@ jobs:
           - "3.9"
           - "3.10"
           - "3.11"
+          - key: "3.12"
+            full: "3.12-dev"
 
     steps:
       - uses: actions/checkout@v3
       - uses: actions/setup-python@v4
         with:
-          python-version: ${{ matrix.python }}
+          python-version: ${{ matrix.python.full || matrix.python }}
 
       - name: Install Ubuntu dependencies
         if: matrix.os == 'Ubuntu'
@@ -129,12 +131,12 @@ jobs:
       # Main check
       - name: Run unit tests
         run: >-
-          nox -s test-${{ matrix.python }} --
+          nox -s test-${{ matrix.python.key || matrix.python }} --
           -m unit
           --verbose --numprocesses auto --showlocals
       - name: Run integration tests
         run: >-
-          nox -s test-${{ matrix.python }} --
+          nox -s test-${{ matrix.python.key || matrix.python }} --
           -m integration
           --verbose --numprocesses auto --showlocals
           --durations=5
diff --git a/docs/html/installation.md b/docs/html/installation.md
index 036a91397a5..c61fceaed2b 100644
--- a/docs/html/installation.md
+++ b/docs/html/installation.md
@@ -103,7 +103,7 @@ $ pip install --upgrade pip
 The current version of pip works on:
 
 - Windows, Linux and MacOS.
-- CPython 3.7, 3.8, 3.9, 3.10 and latest PyPy3.
+- CPython 3.7, 3.8, 3.9, 3.10, 3.11, 3.12, and latest PyPy3.
 
 pip is tested to work on the latest patch version of the Python interpreter,
 for each of the minor versions listed above. Previous patch versions are
diff --git a/noxfile.py b/noxfile.py
index ee03447d359..041d9039974 100644
--- a/noxfile.py
+++ b/noxfile.py
@@ -67,7 +67,7 @@ def should_update_common_wheels() -> bool:
 # -----------------------------------------------------------------------------
 # Development Commands
 # -----------------------------------------------------------------------------
-@nox.session(python=["3.7", "3.8", "3.9", "3.10", "3.11", "pypy3"])
+@nox.session(python=["3.7", "3.8", "3.9", "3.10", "3.11", "3.12", "pypy3"])
 def test(session: nox.Session) -> None:
     # Get the common wheels.
     if should_update_common_wheels():
@@ -89,6 +89,7 @@ def test(session: nox.Session) -> None:
         shutil.rmtree(sdist_dir, ignore_errors=True)
 
     # fmt: off
+    session.install("setuptools")
     session.run(
         "python", "setup.py", "sdist", "--formats=zip", "--dist-dir", sdist_dir,
         silent=True,
@@ -351,6 +352,7 @@ def build_dists(session: nox.Session) -> List[str]:
         )
 
     session.log("# Build distributions")
+    session.install("setuptools", "wheel")
     session.run("python", "setup.py", "sdist", "bdist_wheel", silent=True)
     produced_dists = glob.glob("dist/*")
 
diff --git a/tests/conftest.py b/tests/conftest.py
index 57dd7e68a2b..a183cadf2e9 100644
--- a/tests/conftest.py
+++ b/tests/conftest.py
@@ -49,7 +49,7 @@
 if TYPE_CHECKING:
     from typing import Protocol
 
-    from wsgi import WSGIApplication
+    from _typeshed.wsgi import WSGIApplication
 else:
     # TODO: Protocol was introduced in Python 3.8. Remove this branch when
     # dropping support for Python 3.7.
@@ -645,7 +645,12 @@ def pip(self, *args: Union[str, Path]) -> InMemoryPipResult:
         try:
             returncode = pip_entry_point([os.fspath(a) for a in args])
         except SystemExit as e:
-            returncode = e.code or 0
+            if isinstance(e.code, int):
+                returncode = e.code
+            elif e.code:
+                returncode = 1
+            else:
+                returncode = 0
         finally:
             sys.stdout = orig_stdout
         return InMemoryPipResult(returncode, stdout.getvalue())
diff --git a/tests/functional/test_build_env.py b/tests/functional/test_build_env.py
index 22a71cd3200..20cd181be07 100644
--- a/tests/functional/test_build_env.py
+++ b/tests/functional/test_build_env.py
@@ -1,4 +1,5 @@
 import os
+import sys
 from textwrap import dedent
 from typing import Optional
 
@@ -203,6 +204,31 @@ def test_build_env_overlay_prefix_has_priority(script: PipTestEnvironment) -> No
     assert result.stdout.strip() == "2.0", str(result)
 
 
+if sys.version_info < (3, 12):
+    BUILD_ENV_ERROR_DEBUG_CODE = r"""
+            from distutils.sysconfig import get_python_lib
+            print(
+                f'imported `pkg` from `{pkg.__file__}`',
+                file=sys.stderr)
+            print('system sites:\n  ' + '\n  '.join(sorted({
+                            get_python_lib(plat_specific=0),
+                            get_python_lib(plat_specific=1),
+                    })), file=sys.stderr)
+    """
+else:
+    BUILD_ENV_ERROR_DEBUG_CODE = r"""
+            from sysconfig import get_paths
+            paths = get_paths()
+            print(
+                f'imported `pkg` from `{pkg.__file__}`',
+                file=sys.stderr)
+            print('system sites:\n  ' + '\n  '.join(sorted({
+                            paths['platlib'],
+                            paths['purelib'],
+                    })), file=sys.stderr)
+    """
+
+
 @pytest.mark.usefixtures("enable_user_site")
 def test_build_env_isolation(script: PipTestEnvironment) -> None:
     # Create dummy `pkg` wheel.
@@ -231,8 +257,7 @@ def test_build_env_isolation(script: PipTestEnvironment) -> None:
     run_with_build_env(
         script,
         "",
-        r"""
-        from distutils.sysconfig import get_python_lib
+        f"""
         import sys
 
         try:
@@ -240,17 +265,9 @@ def test_build_env_isolation(script: PipTestEnvironment) -> None:
         except ImportError:
             pass
         else:
-            print(
-                f'imported `pkg` from `{pkg.__file__}`',
-                file=sys.stderr)
-            print('system sites:\n  ' + '\n  '.join(sorted({
-                          get_python_lib(plat_specific=0),
-                          get_python_lib(plat_specific=1),
-                    })), file=sys.stderr)
-            print('sys.path:\n  ' + '\n  '.join(sys.path), file=sys.stderr)
+            {BUILD_ENV_ERROR_DEBUG_CODE}
+            print('sys.path:\\n  ' + '\\n  '.join(sys.path), file=sys.stderr)
             sys.exit(1)
-        """
-        f"""
         # second check: direct check of exclusion of system site packages
         import os
 
diff --git a/tests/functional/test_install.py b/tests/functional/test_install.py
index 8559d93684b..eabddfe58fa 100644
--- a/tests/functional/test_install.py
+++ b/tests/functional/test_install.py
@@ -848,14 +848,18 @@ def test_editable_install__local_dir_no_setup_py(
     )
 
 
+@pytest.mark.skipif(
+    sys.version_info >= (3, 12),
+    reason="Setuptools<64 does not support Python 3.12+",
+)
 @pytest.mark.network
-def test_editable_install__local_dir_no_setup_py_with_pyproject(
+def test_editable_install_legacy__local_dir_no_setup_py_with_pyproject(
     script: PipTestEnvironment,
 ) -> None:
     """
-    Test installing in editable mode from a local directory with no setup.py
-    but that does have pyproject.toml with a build backend that does not support
-    the build_editable hook.
+    Test installing in legacy editable mode from a local directory with no
+    setup.py but that does have pyproject.toml with a build backend that does
+    not support the build_editable hook.
     """
     local_dir = script.scratch_path.joinpath("temp")
     local_dir.mkdir()
@@ -1383,8 +1387,14 @@ def test_install_editable_with_prefix_setup_py(script: PipTestEnvironment) -> No
     _test_install_editable_with_prefix(script, {"setup.py": setup_py})
 
 
+@pytest.mark.skipif(
+    sys.version_info >= (3, 12),
+    reason="Setuptools<64 does not support Python 3.12+",
+)
 @pytest.mark.network
-def test_install_editable_with_prefix_setup_cfg(script: PipTestEnvironment) -> None:
+def test_install_editable_legacy_with_prefix_setup_cfg(
+    script: PipTestEnvironment,
+) -> None:
     setup_cfg = """[metadata]
 name = pkga
 version = 0.1
diff --git a/tests/functional/test_uninstall.py b/tests/functional/test_uninstall.py
index 87e7157497c..be7fe4c3341 100644
--- a/tests/functional/test_uninstall.py
+++ b/tests/functional/test_uninstall.py
@@ -37,6 +37,10 @@ def test_basic_uninstall(script: PipTestEnvironment) -> None:
     assert_all_changes(result, result2, [script.venv / "build", "cache"])
 
 
+@pytest.mark.skipif(
+    sys.version_info >= (3, 12),
+    reason="distutils is no longer available in Python 3.12+",
+)
 def test_basic_uninstall_distutils(script: PipTestEnvironment) -> None:
     """
     Test basic install and uninstall.
@@ -68,6 +72,10 @@ def test_basic_uninstall_distutils(script: PipTestEnvironment) -> None:
     ) in result.stderr
 
 
+@pytest.mark.skipif(
+    sys.version_info >= (3, 12),
+    reason="Setuptools<64 does not support Python 3.12+",
+)
 @pytest.mark.network
 def test_basic_uninstall_with_scripts(script: PipTestEnvironment) -> None:
     """
@@ -101,6 +109,10 @@ def test_uninstall_invalid_parameter(
     assert expected_message in result.stderr
 
 
+@pytest.mark.skipif(
+    sys.version_info >= (3, 12),
+    reason="Setuptools<64 does not support Python 3.12+",
+)
 @pytest.mark.network
 def test_uninstall_easy_install_after_import(script: PipTestEnvironment) -> None:
     """
@@ -126,6 +138,10 @@ def test_uninstall_easy_install_after_import(script: PipTestEnvironment) -> None
     )
 
 
+@pytest.mark.skipif(
+    sys.version_info >= (3, 12),
+    reason="Setuptools<64 does not support Python 3.12+",
+)
 @pytest.mark.network
 def test_uninstall_trailing_newline(script: PipTestEnvironment) -> None:
     """
@@ -337,6 +353,10 @@ def test_uninstall_console_scripts_uppercase_name(script: PipTestEnvironment) ->
     assert not script_name.exists()
 
 
+@pytest.mark.skipif(
+    sys.version_info >= (3, 12),
+    reason="Setuptools<64 does not support Python 3.12+",
+)
 @pytest.mark.network
 def test_uninstall_easy_installed_console_scripts(script: PipTestEnvironment) -> None:
     """
diff --git a/tests/lib/venv.py b/tests/lib/venv.py
index e65a3291230..12aa739db23 100644
--- a/tests/lib/venv.py
+++ b/tests/lib/venv.py
@@ -124,7 +124,7 @@ def _create(self, clear: bool = False) -> None:
                 )
             elif self._venv_type == "venv":
                 builder = _venv.EnvBuilder()
-                context = builder.ensure_directories(self.location)
+                context = builder.ensure_directories(os.fspath(self.location))
                 builder.create_configuration(context)
                 builder.setup_python(context)
                 self.site.mkdir(parents=True, exist_ok=True)