diff --git a/src/pipx/util.py b/src/pipx/util.py
index b2c340818f..e10dac9433 100644
--- a/src/pipx/util.py
+++ b/src/pipx/util.py
@@ -171,6 +171,13 @@ def run_subprocess(
     logger.info(f"running {log_cmd_str}")
     # windows cannot take Path objects, only strings
     cmd_str_list = [str(c) for c in cmd]
+    # Make sure to call the binary using its real path. This matters especially
+    # on Windows when using the packaged app (Microsoft Store) version of
+    # Python, which uses path redirection for sandboxing. If the path to the
+    # executable is redirected, the executable can get confused as to which
+    # directory it's being run from, leading to problems.
+    # See https://github.com/pypa/pipx/issues/1164
+    cmd_str_list[0] = os.path.realpath(cmd_str_list[0])
     completed_process = subprocess.run(
         cmd_str_list,
         env=env,