diff --git a/src/Makevars.win b/src/Makevars.win
index 6ae03f8d..41d469a9 100644
--- a/src/Makevars.win
+++ b/src/Makevars.win
@@ -22,7 +22,7 @@ else
   OPENSSL_LIB_FLAGS = $(shell pkg-config --libs openssl)
 endif
 
-PKG_CPPFLAGS = $(ABSL_CFLAGS) $(OPENSSL_CFLAGS) -DSTRICT_R_HEADERS -DS2_USE_EXACTFLOAT -D_USE_MATH_DEFINES -DNDEBUG -DIS_LITTLE_ENDIAN -DOMIT_STRPTIME -I../src
+PKG_CPPFLAGS = $(ABSL_CFLAGS) $(OPENSSL_CFLAGS) -DSTRICT_R_HEADERS -DS2_USE_EXACTFLOAT -D_USE_MATH_DEFINES -DNDEBUG -DOMIT_STRPTIME -I../src
 PKG_LIBS = -Ls2 -ls2static $(ABSL_LIB_FLAGS) $(OPENSSL_LIB_FLAGS)
 
 CXX_STD = CXX17