diff --git a/.Rhistory b/.Rhistory
index 1b74564..e4d3662 100644
--- a/.Rhistory
+++ b/.Rhistory
@@ -1,512 +1,26 @@
-test = list('est'=df)
-View(test)
-install.packages('GOplot')
-install.packages("GOplot")
-df <- read.csv('kegg_serum.csv')
-View(df)
-# # Building the circ object
-circ <- circle_dat(EC$david, EC$genelist)
-## Not run:
-# # Load the included dataset
-data(EC)
-library('GOplot')
-## Not run:
-# # Load the included dataset
-data(EC)
-circ <- circle_dat(EC$david, EC$genelist)
-View(circ)
-df <- read.csv('kegg_serum.csv')
-GOCircle(df)
-summary(df)
-GOCircle(df)
-install_github('wencke/wencke.github.io')
-library(devt)
-library(devtools)
-install_github('wencke/wencke.github.io')
-library(devtools)
-install_github('wencke/wencke.github.io')
-devtools::install_github("wencke/wencke.github.io")
-install.packages('htmltools')
-install.packages("htmltools")
-library(htmltools)
-devtools::install_github("wencke/wencke.github.io")
-install.packages('GOplot')
-df <- read.csv('kegg_serum.csv')
-GOCircle(df)
-GOCircle(df)
-library(GOplot)
-df <- read.csv('kegg_serum.csv')
-GOCircle(df)
-detach("package:base", unload = TRUE)
-detach("package:GOplot", unload = TRUE)
-library(GOplot)
-devtools::install_github("wencke/wencke.github.io")
-df <- read.csv('kegg_serum.csv')
-GOCircle(df)
-df <- read.csv('kegg_serum.csv')
-View(df)
-GOCircle(df)
-install.packages('corrplot')
-library(corrplot)
-setwd("C:/Data/Analysis/DAGMAR_IIH/IIH_Serum")
-data = read.csv("corr_serum.csv")
-M = cor(data)
-mode(data)
-data = as.matrix(data)
-mode(data)
-df = read.delim(file = 'corr_serum.tsv')
-M = cor(df)
-df = read.delim(file = 'corr_serum.tsv', header=T)
-M = cor(df)
-mode(df)
-df = read.delim(file = 'corr_serum.tsv', header=TRUE, row.names = 1)
-M = cor(df)
-corrplot(M, method = 'color')
-# Objective
-- Enrichment of formerly sialylated N-linked (SAN-) glycopeptides using MagReSyn® Zr-IMAC HP
-setwd("C:/Data/Projects/PTMs/MISAME3/Feb_2024_MISAME/NMP")
-# download package from bioconductor
-if (!requireNamespace('BiocManager', quietly = TRUE))
-install.packages('BiocManager')
-BiocManager::install('EnhancedVolcano')
-# load the package
-library(EnhancedVolcano)
-df = read.delim(file = 'volcano.tsv', header=TRUE, row.names = 1)
-# download package from bioconductor
-if (!requireNamespace('BiocManager', quietly = TRUE))
-install.packages('BiocManager')
-BiocManager::install('EnhancedVolcano')
-# load the package
-library(EnhancedVolcano)
-df = read.delim(file = 'volcano.tsv', header=TRUE, row.names = 1)
-# download package from bioconductor
-if (!requireNamespace('BiocManager', quietly = TRUE))
-install.packages('BiocManager')
-BiocManager::install('EnhancedVolcano')
-# load the package
-library(EnhancedVolcano)
-df = read.delim(file = 'volcano.tsv', header=TRUE, row.names = 1)
-View(df)
-setwd("C:/Data/Projects/PTMs/MISAME3/Feb_2024_MISAME/NMP")
-df = read.delim(file = 'volcano.tsv', header=TRUE, row.names = 1)
-View(df)
-df = read.delim(file = 'volcano.tsv', header=TRUE, row.names = 1)
-View(df)
-EnhancedVolcano(df,
-lab = rownames(df),
-x = 'log2FoldChange',
-y = 'pvalue',
-selectLab = c('PGRP2_HUMAN','ECM_HUMAN','PSG7_HUMAN',
-'LG3BP_HUMAN','BTD_HUMAN','FBLN!_HUMAN'),
-xlab = bquote(~Log[2]~ 'fold change'),
-pCutoff = 0.1,
-FCcutoff = 0.1,
-pointSize = 4.0,
-labSize = 6.0,
-labCol = 'black',
-labFace = 'bold',
-boxedLabels = TRUE,
-colAlpha = 1,
-legendPosition = 'right',
-legendLabSize = 8,
-legendIconSize = 4.0,
-drawConnectors = TRUE,
-widthConnectors = 1.0,
-colConnectors = 'black',xlim=c(-2, 2), ylim = c(0,8))
-EnhancedVolcano(df,
-lab = rownames(df),
-x = 'log2FoldChange',
-y = 'pvalue',
-selectLab = c('PGRP2_HUMAN','ECM_HUMAN','PSG7_HUMAN',
-'LG3BP_HUMAN','BTD_HUMAN','FBLN!_HUMAN'),
-xlab = bquote(~Log[2]~ 'fold change'),
-pCutoff = 0.05,
-FCcutoff = 1,
-pointSize = 4.0,
-labSize = 6.0,
-labCol = 'black',
-labFace = 'bold',
-boxedLabels = TRUE,
-colAlpha = 1,
-legendPosition = 'right',
-legendLabSize = 8,
-legendIconSize = 4.0,
-drawConnectors = TRUE,
-widthConnectors = 1.0,
-colConnectors = 'black',xlim=c(-2, 2), ylim = c(0,8))
-EnhancedVolcano(df,
-lab = rownames(df),
-x = 'log2FoldChange',
-y = 'pvalue',
-selectLab = c('PGRP2_HUMAN','ECM_HUMAN','PSG7_HUMAN',
-'LG3BP_HUMAN','BTD_HUMAN','FBLN!_HUMAN'),
-xlab = bquote(~Log[2]~ 'fold change'),
-pCutoff = 0.05,
-FCcutoff = 1,
-pointSize = 4.0,
-labSize = 6.0,
-labCol = 'black',
-labFace = 'bold',
-boxedLabels = TRUE,
-colAlpha = 1,
-legendPosition = 'right',
-legendLabSize = 8,
-legendIconSize = 4.0,
-drawConnectors = TRUE,
-widthConnectors = 1.0,
-colConnectors = 'black',xlim=c(-2, 2), ylim = c(0,3))
-View(data)
-setwd("C:/Users/BhosaleS/Downloads")
-df = read.delim(file = 'corr.tsv', header=TRUE, row.names = 1)
-df = read.delim(file = 'corr.tsv', header=TRUE, row.names = 1)
-View(df)
-df = read.delim(file = 'corr.tsv', header=TRUE)
-View(df)
-View(df)
-df = read.delim(file = 'corr.tsv', header=TRUE, row.names = 1)
-View(df)
-sp <- ggscatter(df, x = "CACNA2D3", y = "ICP_cm_H2O",
-add = "reg.line",  # Add regressin line
-add.params = list(color = "blue", fill = "lightgray"), # Customize reg. line
-conf.int = TRUE # Add confidence interval
-)
-install.packages('ggscatter')
-library(ggscatter)
-install.packages("ggScatRidges")
-library(ggScatRidges)
-library(ggscatter)
-install.packages('ggscatter')
-install.packages("ggpubr")
-install.packages("ggpubr")
-library(ggscatter)
-library(ggscatter)
-library(ggpubr)
-library(ggscatter)
-library(ggscatter)
-install.packages("ggscatter")
-library(ggscatter)
-sp <- ggscatter(df, x = "CACNA2D3", y = "ICP_cm_H2O",
-add = "reg.line",  # Add regressin line
-add.params = list(color = "blue", fill = "lightgray"), # Customize reg. line
-conf.int = TRUE # Add confidence interval
-)
-# Add correlation coefficient
-sp + stat_cor(method = "pearson", label.x = 3, label.y = 30)
-sp <- ggscatter(df, x = "CACNA2D3", y = "ICP_cm_H2O",
-add = "reg.line",  # Add regressin line
-add.params = list(color = "blue", fill = "lightgray"), # Customize reg. line
-conf.int = TRUE, # Add confidence interval
-xlim=c(10, 13), # setting up the x and y-axis dimension
-)
-# Add correlation coefficient
-sp + stat_cor(method = "pearson", label.x = 3, label.y = 30)
-sp <- ggscatter(df, x = "CACNA2D3", y = "ICP_cm_H2O",
-add = "reg.line",  # Add regressin line
-add.params = list(color = "blue", fill = "lightgray"), # Customize reg. line
-conf.int = TRUE, # Add confidence interval
-xlim=c(10.5, 13), # setting up the x and y-axis dimension
-)
-# Add correlation coefficient
-sp + stat_cor(method = "pearson", label.x = 3, label.y = 30)
-sp + stat_cor(p.accuracy = 0.001, r.accuracy = 0.01)
-sp + stat_cor(aes(color = group), label.x = 3)
-sp <- ggscatter(df, x = "CACNA2D3", y = "ICP_cm_H2O",
-color = "group", palette = "jco",
-add = "reg.line", conf.int = TRUE)
-sp + stat_cor(aes(color = group), label.x = 3)
-sp <- ggscatter(df, x = "CACNA2D3", y = "ICP_cm_H2O",
-add = "reg.line",  # Add regressin line
-add.params = list(color = "blue", fill = "lightgray"), # Customize reg. line
-conf.int = TRUE, # Add confidence interval
-xlim=c(10.5, 13), # setting up the x and y-axis dimension
-)
-# Add correlation coefficient
-sp + stat_cor(method = "pearson", label.x = 3, label.y = 30)
-sp + stat_cor(p.accuracy = 0.001, r.accuracy = 0.01)
-sp <- ggscatter(df, x = "CACNA2D3", y = "ICP_cm_H2O",
-add = "reg.line",  # Add regressin line
-add.params = list(color = "blue", fill = "lightgray"), # Customize reg. line
-conf.int = TRUE, # Add confidence interval
-xlim=c(10.5, 13), # setting up the x and y-axis dimension
-group = rep(c('IIH', 'Con'), each = 15),
-)
-# Add correlation coefficient
-sp + stat_cor(method = "pearson", label.x = 3, label.y = 30)
-sp + stat_cor(p.accuracy = 0.001, r.accuracy = 0.01)
-sp + stat_cor(p.accuracy = 0.001, r.accuracy = 0.01) + geom_line(aes(col = group))
-sp + stat_cor(p.accuracy = 0.001, r.accuracy = 0.01) + geom_dotplot(aes(col = group))
-sp + stat_cor(p.accuracy = 0.001, r.accuracy = 0.01) + geom_point(aes(col = group))
-library(ggscatter)
-esquisser()
-library(esquisse)
-library(esquisse)
-esquisser()
-df = read.delim(file = 'corr.tsv', header=TRUE, row.names = 1)
-ggplot(df) +
-aes(x = CACNA2D3, y = ICP_cm_H2O, colour = group) +
-geom_point(shape = "circle", size = 1.5) +
-scale_color_hue(direction = 1) +
-theme_minimal()
-ggplot(df) +
-aes(x = CACNA2D3, y = ICP_cm_H2O, colour = group) +
-geom_point(shape = "circle", size = 3) +
-scale_color_hue(direction = 1) +
-theme_minimal()
-ggplot(df) +
-aes(x = CACNA2D3, y = ICP_cm_H2O, colour = group, add = "reg.line") +
-geom_point(shape = "circle", size = 3) +
-scale_color_hue(direction = 1) +
-theme_minimal()
-df = read.delim(file = 'corr_basp1.tsv', header=TRUE, row.names = 1)
-setwd("C:/Users/BhosaleS/Downloads")
-df = read.delim(file = 'corr_basp1.tsv', header=TRUE, row.names = 1)
-df = read.delim(file = 'corr_basp1.tsv', header=TRUE, row.names = 1)
-View(df)
-df = read.delim(file = 'corr_basp1.tsv', header=TRUE, row.names = 1)
-View(df)
-sp <- ggscatter(df, x = "BASP1", y = "ICP_cm_H2O",
-add = "reg.line",  # Add regressin line
-add.params = list(color = "blue", fill = "lightgray"), # Customize reg. line
-conf.int = TRUE, # Add confidence interval
-xlim=c(14, 17), # setting up the x and y-axis dimension
-group = rep(c('IIH', 'Con'), each = 15),
-)
-# Add correlation coefficient
-sp + stat_cor(method = "pearson", label.x = 3, label.y = 30)
-sp + stat_cor(p.accuracy = 0.001, r.accuracy = 0.01) + geom_point(aes(col = group))
-sp <- ggscatter(df, x = "BASP1", y = "ICP_cm_H2O",
-add = "reg.line",  # Add regressin line
-add.params = list(color = "blue", fill = "lightgray"), # Customize reg. line
-conf.int = TRUE, # Add confidence interval
-xlim=c(14, 17), # setting up the x and y-axis dimension
-group = rep(c('IIH', 'Con')(c('49','32'))),
-)
-# Add correlation coefficient
-sp + stat_cor(method = "pearson", label.x = 3, label.y = 30)
-sp + stat_cor(p.accuracy = 0.001, r.accuracy = 0.01) + geom_point(aes(col = group))
-sp <- ggscatter(df, x = "BASP1", y = "ICP_cm_H2O",
-add = "reg.line",  # Add regressin line
-add.params = list(color = "blue", fill = "lightgray"), # Customize reg. line
-conf.int = TRUE, # Add confidence interval
-xlim=c(14, 17), # setting up the x and y-axis dimension
-group = rep(c('IIH',49),('Con',32))
-# Add correlation coefficient
-sp + stat_cor(method = "pearson", label.x = 3, label.y = 30)
-sp + stat_cor(p.accuracy = 0.001, r.accuracy = 0.01) + geom_point(aes(col = group))
-sp <- ggscatter(df, x = "BASP1", y = "ICP_cm_H2O",
-add = "reg.line",  # Add regressin line
-add.params = list(color = "blue", fill = "lightgray"), # Customize reg. line
-conf.int = TRUE, # Add confidence interval
-xlim=c(14, 17), # setting up the x and y-axis dimension
-group = rep(c('IIH', 'Con'), each = 49),
-)
-# Add correlation coefficient
-sp + stat_cor(method = "pearson", label.x = 3, label.y = 30)
-sp + stat_cor(p.accuracy = 0.001, r.accuracy = 0.01) + geom_point(aes(col = group))
-df = read.delim(file = 'corr_basp1.tsv', header=TRUE, row.names = 1)
-View(df)
-group = c(rep("IIH",49), rep("Con",32))
-sp <- ggscatter(df, x = "BASP1", y = "ICP_cm_H2O",
-add = "reg.line",  # Add regressin line
-add.params = list(color = "blue", fill = "lightgray"), # Customize reg. line
-conf.int = TRUE, # Add confidence interval
-xlim=c(14, 17), # setting up the x and y-axis dimension
-group = group,
-)
-# Add correlation coefficient
-sp + stat_cor(method = "pearson", label.x = 3, label.y = 30)
-sp + stat_cor(p.accuracy = 0.001, r.accuracy = 0.01) + geom_point(aes(col = group))
-df = read.delim(file = 'corr_gmcl2.tsv', header=TRUE, row.names = 1)
-View(df)
-group = c(rep("IIH",49), rep("Con",32))
-sp <- ggscatter(df, x = "BASP1", y = "ICP_cm_H2O",
-add = "reg.line",  # Add regressin line
-add.params = list(color = "blue", fill = "lightgray"), # Customize reg. line
-conf.int = TRUE, # Add confidence interval
-xlim=c(14, 17), # setting up the x and y-axis dimension
-group = group,
-)
-# Add correlation coefficient
-sp + stat_cor(method = "pearson", label.x = 3, label.y = 30)
-sp <- ggscatter(df, x = "GMCL2", y = "ICP_cm_H2O",
-add = "reg.line",  # Add regressin line
-add.params = list(color = "blue", fill = "lightgray"), # Customize reg. line
-conf.int = TRUE, # Add confidence interval
-xlim=c(14, 17), # setting up the x and y-axis dimension
-group = group,
-)
-# Add correlation coefficient
-sp + stat_cor(method = "pearson", label.x = 3, label.y = 30)
-sp + stat_cor(p.accuracy = 0.001, r.accuracy = 0.01) + geom_point(aes(col = group))
-df = read.delim(file = 'corr_gmcl2.tsv', header=TRUE, row.names = 1)
-View(df)
-group = c(rep("IIH",49), rep("Con",32))
-sp <- ggscatter(df, x = "GMCL2", y = "ICP_cm_H2O",
-add = "reg.line",  # Add regressin line
-add.params = list(color = "blue", fill = "lightgray"), # Customize reg. line
-conf.int = TRUE, # Add confidence interval
-xlim=c(14, 17), # setting up the x and y-axis dimension
-group = group,
-)
-# Add correlation coefficient
-sp + stat_cor(method = "pearson", label.x = 3, label.y = 30)
-sp + stat_cor(p.accuracy = 0.001, r.accuracy = 0.01) + geom_point(aes(col = group))
-df = read.delim(file = 'corr_basp1.tsv', header=TRUE, row.names = 1)
-View(df)
-group = c(rep("IIH",49), rep("Con",32))
-sp <- ggscatter(df, x = "GMCL2", y = "ICP_cm_H2O",
-add = "reg.line",  # Add regressin line
-add.params = list(color = "blue", fill = "lightgray"), # Customize reg. line
-conf.int = TRUE, # Add confidence interval
-xlim=c(14, 17), # setting up the x and y-axis dimension
-group = group,
-)
-# Add correlation coefficient
-sp + stat_cor(method = "pearson", label.x = 3, label.y = 30)
-sp <- ggscatter(df, x = "BASP1", y = "ICP_cm_H2O",
-add = "reg.line",  # Add regressin line
-add.params = list(color = "blue", fill = "lightgray"), # Customize reg. line
-conf.int = TRUE, # Add confidence interval
-xlim=c(14, 17), # setting up the x and y-axis dimension
-group = group,
-)
-# Add correlation coefficient
-sp + stat_cor(method = "pearson", label.x = 3, label.y = 30)
-sp <- ggscatter(df, x = "BASP1", y = "ICP_cm_H2O",
-add = "reg.line",  # Add regressin line
-add.params = list(color = "blue", fill = "lightgray"), # Customize reg. line
-conf.int = TRUE, # Add confidence interval
-group = group,
-)
-# Add correlation coefficient
-sp + stat_cor(method = "pearson", label.x = 3, label.y = 30)
-df = read.delim(file = 'corr_basp1.tsv', header=TRUE, row.names = 1)
-View(df)
-group = c(rep("IIH",49), rep("Con",32))
-sp <- ggscatter(df, x = "BASP1", y = "ICP_cm_H2O",
-add = "reg.line",  # Add regressin line
-add.params = list(color = "blue", fill = "lightgray"), # Customize reg. line
-conf.int = TRUE, # Add confidence interval
-xlim=c(14, 17), # setting up the x and y-axis dimension
-group = group,
-)
-sp <- ggscatter(df, x = "BASP1", y = "ICP_cm_H2O",
-add = "reg.line",  # Add regressin line
-add.params = list(color = "blue", fill = "lightgray"), # Customize reg. line
-conf.int = TRUE, # Add confidence interval
-# setting up the x and y-axis dimension
-group = group,
-)
-# Add correlation coefficient
-sp + stat_cor(method = "pearson", label.x = 3, label.y = 30)
-sp + stat_cor(p.accuracy = 0.001, r.accuracy = 0.01) + geom_point(aes(col = group))
-# Add correlation coefficient
-sp + stat_cor(method = "spearman", label.x = 3, label.y = 30)
-sp + stat_cor(p.accuracy = 0.001, r.accuracy = 0.01) + geom_point(aes(col = group))
-df = read.delim(file = 'corr_basp1.tsv', header=TRUE, row.names = 1)
-View(df)
-group = c(rep("IIH",49), rep("Con",32))
-sp <- ggscatter(df, x = "BASP1", y = "ICP_cm_H2O",
-add = "reg.line",  # Add regressin line
-add.params = list(color = "blue", fill = "lightgray"), # Customize reg. line
-conf.int = TRUE, # Add confidence interval
-group = group,
-)
-# Add correlation coefficient
-sp + stat_cor(method = "pearson", label.x = 3, label.y = 30)
-sp + stat_cor(p.accuracy = 0.001, r.accuracy = 0.01) + geom_point(aes(col = group))
-sp + xlim=c(14, 17) # setting up the x and y-axis dimension
-sp <- ggscatter(df, x = "BASP1", y = "ICP_cm_H2O",
-add = "reg.line",  # Add regressin line
-add.params = list(color = "blue", fill = "lightgray"), # Customize reg. line
-conf.int = TRUE, # Add confidence interval
-group = group,
-)
-# Add correlation coefficient
-sp + stat_cor(method = "pearson", label.x = 3, label.y = 30)
-sp + stat_cor(p.accuracy = 0.001, r.accuracy = 0.01) + geom_point(aes(col = group))
-df = read.delim(file = 'corr_CACNA2D3.tsv', header=TRUE, row.names = 1)
-View(df)
-group = c(rep("IIH",49), rep("Con",32))
-sp <- ggscatter(df, x = "CACNA2D3", y = "ICP_cm_H2O",
-add = "reg.line",  # Add regressin line
-add.params = list(color = "blue", fill = "lightgray"), # Customize reg. line
-conf.int = TRUE, # Add confidence interval
-group = group,
-)
-# Add correlation coefficient
-sp + stat_cor(method = "pearson", label.x = 3, label.y = 30)
-sp + stat_cor(p.accuracy = 0.001, r.accuracy = 0.01) + geom_point(aes(col = group))
-df = read.delim(file = 'corr_islr.tsv', header=TRUE, row.names = 1)
-View(df)
-group = c(rep("IIH",49), rep("Con",32))
-sp <- ggscatter(df, x = "ISLR", y = "ICP_cm_H2O",
-add = "reg.line",  # Add regressin line
-add.params = list(color = "blue", fill = "lightgray"), # Customize reg. line
-conf.int = TRUE, # Add confidence interval
-group = group,
-)
-# Add correlation coefficient
-sp + stat_cor(method = "pearson", label.x = 3, label.y = 30)
-sp + stat_cor(p.accuracy = 0.001, r.accuracy = 0.01) + geom_point(aes(col = group))
-df = read.delim(file = 'corr_prg4.tsv', header=TRUE, row.names = 1)
-View(df)
-group = c(rep("IIH",49), rep("Con",32))
-sp <- ggscatter(df, x = "PRG4", y = "ICP_cm_H2O",
-add = "reg.line",  # Add regressin line
-add.params = list(color = "blue", fill = "lightgray"), # Customize reg. line
-conf.int = TRUE, # Add confidence interval
-group = group,
-)
-# Add correlation coefficient
-sp + stat_cor(method = "pearson", label.x = 3, label.y = 30)
-sp + stat_cor(p.accuracy = 0.001, r.accuracy = 0.01) + geom_point(aes(col = group))
-df = read.delim(file = 'corr_prg4.tsv', header=TRUE, row.names = 1)
-View(df)
-group = c(rep("IIH",49), rep("Con",32))
-sp <- ggscatter(df, x = "PRG4", y = "BMI",
-add = "reg.line",  # Add regressin line
-add.params = list(color = "blue", fill = "lightgray"), # Customize reg. line
-conf.int = TRUE, # Add confidence interval
-group = group,
-)
-# Add correlation coefficient
-sp + stat_cor(method = "pearson", label.x = 3, label.y = 30)
-sp + stat_cor(p.accuracy = 0.001, r.accuracy = 0.01) + geom_point(aes(col = group))
-df = read.delim(file = 'corr_mdh.tsv', header=TRUE, row.names = 1)
-View(df)
-group = c(rep("IIH",49), rep("Con",32))
-sp <- ggscatter(df, x = "MDH", y = "BMI",
-add = "reg.line",  # Add regressin line
-add.params = list(color = "blue", fill = "lightgray"), # Customize reg. line
-conf.int = TRUE, # Add confidence interval
-group = group,
-)
-# Add correlation coefficient
-sp + stat_cor(method = "pearson", label.x = 3, label.y = 30)
-sp + stat_cor(p.accuracy = 0.001, r.accuracy = 0.01) + geom_point(aes(col = group))
-sp <- ggscatter(df, x = "MDH1", y = "BMI",
-add = "reg.line",  # Add regressin line
-add.params = list(color = "blue", fill = "lightgray"), # Customize reg. line
-conf.int = TRUE, # Add confidence interval
-group = group,
-)
-# Add correlation coefficient
-sp + stat_cor(method = "pearson", label.x = 3, label.y = 30)
-sp <- ggscatter(df, x = "MDH1", y = "ICP_cm_H2O",
-add = "reg.line",  # Add regressin line
-add.params = list(color = "blue", fill = "lightgray"), # Customize reg. line
-conf.int = TRUE, # Add confidence interval
-group = group,
-)
-# Add correlation coefficient
-sp + stat_cor(method = "pearson", label.x = 3, label.y = 30)
-sp + stat_cor(p.accuracy = 0.001, r.accuracy = 0.01) + geom_point(aes(col = group))
-if(!requireNamespace("devtools", quietly = TRUE)){
-install.packages("devtools")
-}
-devtools::install_github("marseille-proteomique/DIAgui")
-library(DIAgui)
-library(DIAgui)
-runDIAgui()
-runDIAgui()
+install.packages('rmarkdown')
+library(rmarkdown)
+library(rmarkdown)
+render("path/to/file.Rmd")
+file.exists("~/.Rprofile")
+library(rmarkdown)
+library(rmarkdown)
+library(rmarkdown)
+install.packages('downlit')
+install.packages('xml2')
+library(downlit)
+library(xml2)
+library(rmarkdown)
+library(rmarkdown)
+install.packages('rmarkdown')
+install.packages("rmarkdown")
+library(rmarkdown)
+install.packages('rmarkdown')
+install.packages('downlit')
+install.packages('xml2')
+library(rmarkdown)
+library(downlit)
+library(xml2)
+setwd("C:/Users/BhosaleS/Documents/GitHub/santoshdbhosale.github.io")
+utils::packageVersion("rmarkdown")
+utils::packageVersion("rmarkdown")
diff --git a/.Rproj.user/224B9E6C/jobs/70B54F46-output.json b/.Rproj.user/224B9E6C/jobs/BB71370C-output.json
similarity index 66%
rename from .Rproj.user/224B9E6C/jobs/70B54F46-output.json
rename to .Rproj.user/224B9E6C/jobs/BB71370C-output.json
index 9a5840c..74c7812 100644
--- a/.Rproj.user/224B9E6C/jobs/70B54F46-output.json
+++ b/.Rproj.user/224B9E6C/jobs/BB71370C-output.json
@@ -1,4 +1,4 @@
-[2,"\n"]
+[1,"==> quarto preview --render all --no-watch-inputs --no-browse\n\n"]
 [1,"Rendering:\n"]
 [1,"\r[ 1/10] 404.qmd\n"]
 [1,"\r[ 2/10] about\\index.qmd\n"]
@@ -9,11 +9,14 @@
 [1,"\r[ 7/10] blog\\Serum-Proteomics-Atherosclerosis\\index.qmd\n"]
 [1,"\r[ 8/10] blog\\Serum-Proteomics-Pre-diabetic\\index.qmd\n"]
 [1,"\r[ 9/10] cv\\index.qmd\n"]
-[1,"Error in loadNamespace(name) : there is no package called 'rmarkdown'\r\nCalls: :: ... loadNamespace -> withRestarts -> withOneRestart -> doWithOneRestart\r\nExecution halted\r\n"]
-[1,"WARNING: Unable to perform code-link (code-link requires R packages rmarkdown, downlit, and xml2)\n\r[10/10] index.qmd\n"]
+[1,"failed to create process.\r\nWARNING: Unable to perform code-link (code-link requires R packages rmarkdown, downlit, and xml2)\n"]
+[1,"\r[10/10] index.qmd\n"]
 [1,"\n"]
 [1,"Watching files for changes\nBrowse at http://localhost:22222/\n"]
 [1,"GET: /\n"]
 [1,"  /img/logo.png (404: Not Found)\n"]
+[1,"GET: /cv/\n  /img/logo.png (404: Not Found)\n"]
+[1,"GET: /blog/\n"]
+[1,"  /img/logo.png (404: Not Found)\n"]
 [1,"GET: /\n"]
 [1,"  /img/logo.png (404: Not Found)\n"]
diff --git a/.Rproj.user/224B9E6C/pcs/source-pane.pper b/.Rproj.user/224B9E6C/pcs/source-pane.pper
index 965e284..be19143 100644
--- a/.Rproj.user/224B9E6C/pcs/source-pane.pper
+++ b/.Rproj.user/224B9E6C/pcs/source-pane.pper
@@ -1,4 +1,4 @@
 {
-    "activeTab": 1,
+    "activeTab": 0,
     "activeTabSourceWindow0": 0
 }
\ No newline at end of file
diff --git a/.Rproj.user/224B9E6C/pcs/windowlayoutstate.pper b/.Rproj.user/224B9E6C/pcs/windowlayoutstate.pper
index 327158e..4d843a5 100644
--- a/.Rproj.user/224B9E6C/pcs/windowlayoutstate.pper
+++ b/.Rproj.user/224B9E6C/pcs/windowlayoutstate.pper
@@ -1,14 +1,14 @@
 {
     "left": {
-        "splitterpos": 231,
+        "splitterpos": 344,
         "topwindowstate": "NORMAL",
-        "panelheight": 592,
-        "windowheight": 630
+        "panelheight": 951,
+        "windowheight": 989
     },
     "right": {
-        "splitterpos": 329,
-        "topwindowstate": "MINIMIZE",
-        "panelheight": 592,
-        "windowheight": 630
+        "splitterpos": 543,
+        "topwindowstate": "NORMAL",
+        "panelheight": 951,
+        "windowheight": 989
     }
 }
\ No newline at end of file
diff --git a/.Rproj.user/224B9E6C/pcs/workbench-pane.pper b/.Rproj.user/224B9E6C/pcs/workbench-pane.pper
index d612aa7..ab5e950 100644
--- a/.Rproj.user/224B9E6C/pcs/workbench-pane.pper
+++ b/.Rproj.user/224B9E6C/pcs/workbench-pane.pper
@@ -1,5 +1,5 @@
 {
     "TabSet1": 3,
-    "TabSet2": 4,
+    "TabSet2": 0,
     "TabZoom": {}
 }
\ No newline at end of file
diff --git a/.Rproj.user/224B9E6C/rmd-outputs b/.Rproj.user/224B9E6C/rmd-outputs
index 2fd2252..82490c6 100644
--- a/.Rproj.user/224B9E6C/rmd-outputs
+++ b/.Rproj.user/224B9E6C/rmd-outputs
@@ -1,7 +1,7 @@
 C:/Data/Documents/Personal/CV-first-repo-master/CV_ccmb.pdf
 C:/Data/Documents/Personal/CV-first-repo-master/CV_ccmb.pdf
 
-
+C:/Data/Documents/Personal/CV-first-repo-master/CV_edit1.pdf
 
 
 
diff --git a/.Rproj.user/224B9E6C/sources/prop/11366684 b/.Rproj.user/224B9E6C/sources/prop/11366684
index bb27690..8a86b43 100644
--- a/.Rproj.user/224B9E6C/sources/prop/11366684
+++ b/.Rproj.user/224B9E6C/sources/prop/11366684
@@ -1,4 +1,6 @@
 {
     "source_window_id": "",
-    "Source": "Source"
+    "Source": "Source",
+    "cursorPosition": "5,9",
+    "scrollLine": "0"
 }
\ No newline at end of file
diff --git a/.Rproj.user/224B9E6C/sources/prop/36D7AB51 b/.Rproj.user/224B9E6C/sources/prop/36D7AB51
new file mode 100644
index 0000000..883d450
--- /dev/null
+++ b/.Rproj.user/224B9E6C/sources/prop/36D7AB51
@@ -0,0 +1,6 @@
+{
+    "source_window_id": "",
+    "Source": "Source",
+    "cursorPosition": "15,6",
+    "scrollLine": "3"
+}
\ No newline at end of file
diff --git a/.Rproj.user/224B9E6C/sources/prop/3F79B444 b/.Rproj.user/224B9E6C/sources/prop/3F79B444
index 72f0f40..f1565c1 100644
--- a/.Rproj.user/224B9E6C/sources/prop/3F79B444
+++ b/.Rproj.user/224B9E6C/sources/prop/3F79B444
@@ -1,11 +1,11 @@
 {
     "source_window_id": "",
     "Source": "Source",
-    "cursorPosition": "25,0",
-    "scrollLine": "21",
+    "cursorPosition": "0,0",
+    "scrollLine": "15",
     "rmdVisualMode": "false",
     "rmdVisualWrapConfigured": "true",
     "docOutlineVisible": "1",
     "rmdVisualCollapsedChunks": "",
-    "rmdVisualModeLocation": "948:925.3333129882812"
+    "rmdVisualModeLocation": "2:587.3333129882812"
 }
\ No newline at end of file
diff --git a/.Rproj.user/224B9E6C/sources/prop/741BBE12 b/.Rproj.user/224B9E6C/sources/prop/741BBE12
new file mode 100644
index 0000000..bb27690
--- /dev/null
+++ b/.Rproj.user/224B9E6C/sources/prop/741BBE12
@@ -0,0 +1,4 @@
+{
+    "source_window_id": "",
+    "Source": "Source"
+}
\ No newline at end of file
diff --git a/.Rproj.user/224B9E6C/sources/prop/75320100 b/.Rproj.user/224B9E6C/sources/prop/75320100
new file mode 100644
index 0000000..0f1c1c1
--- /dev/null
+++ b/.Rproj.user/224B9E6C/sources/prop/75320100
@@ -0,0 +1,6 @@
+{
+    "source_window_id": "",
+    "Source": "Source",
+    "cursorPosition": "3,80",
+    "scrollLine": "0"
+}
\ No newline at end of file
diff --git a/.Rproj.user/224B9E6C/sources/prop/9ED00626 b/.Rproj.user/224B9E6C/sources/prop/9ED00626
new file mode 100644
index 0000000..c4706b1
--- /dev/null
+++ b/.Rproj.user/224B9E6C/sources/prop/9ED00626
@@ -0,0 +1,6 @@
+{
+    "source_window_id": "",
+    "Source": "Source",
+    "cursorPosition": "134,8",
+    "scrollLine": "0"
+}
\ No newline at end of file
diff --git a/.Rproj.user/224B9E6C/sources/prop/F9FA7054 b/.Rproj.user/224B9E6C/sources/prop/F9FA7054
index 13065b8..c230b58 100644
--- a/.Rproj.user/224B9E6C/sources/prop/F9FA7054
+++ b/.Rproj.user/224B9E6C/sources/prop/F9FA7054
@@ -1,11 +1,11 @@
 {
     "source_window_id": "",
     "Source": "Source",
-    "cursorPosition": "18,0",
-    "scrollLine": "17",
+    "cursorPosition": "16,311",
+    "scrollLine": "0",
     "rmdVisualMode": "false",
     "rmdVisualWrapConfigured": "true",
-    "docOutlineVisible": "1",
+    "docOutlineVisible": "0",
     "rmdVisualCollapsedChunks": "",
     "rmdVisualModeLocation": "82:0"
 }
\ No newline at end of file
diff --git a/.Rproj.user/224B9E6C/sources/prop/INDEX b/.Rproj.user/224B9E6C/sources/prop/INDEX
index a459088..7a0fd12 100644
--- a/.Rproj.user/224B9E6C/sources/prop/INDEX
+++ b/.Rproj.user/224B9E6C/sources/prop/INDEX
@@ -1,5 +1,6 @@
 C%3A%2FData%2FAnalysis%2FPREDI%2FFragPipe%2FMP%2FBatch1-2_results%2F20220818_limmaBatchCorrection.R="B3528A83"
 C%3A%2FData%2FAnalysis%2FPREDI%2FFragPipe%2FMP%2FBatch1-2_results%2Fbatchqc_report.Rmd="E657EBE5"
+C%3A%2FData%2FArticles%2FManuscript%2FAstral%2Fcv.R="9ED00626"
 C%3A%2FData%2FArticles%2FManuscript%2FEDIA%2F20231117_Heatmap%2FHeatmap.R="6281908E"
 C%3A%2FData%2FArticles%2FManuscript%2FEDIA%2FNewHeatmap%2FENRC_other.csv="C0E71FA9"
 C%3A%2FData%2FArticles%2FManuscript%2FEDIA%2FNewHeatmap%2FMinigut_R_script.R="64549641"
@@ -11,6 +12,7 @@ C%3A%2FData%2FArticles%2FManuscript%2FNOSecret%2FNewHeatmap%2FMinigut_R_script_a
 C%3A%2FData%2FDocuments%2FPersonal%2FCV-first-repo-master%2FCV.Rmd="703AEF0D"
 C%3A%2FData%2FDocuments%2FPersonal%2FCV-first-repo-master%2FCV1.Rmd="2ED4760C"
 C%3A%2FData%2FDocuments%2FPersonal%2FCV-first-repo-master%2FCV_ccmb.Rmd="959914B0"
+C%3A%2FData%2FDocuments%2FPersonal%2FCV-first-repo-master%2FCV_edit1.Rmd="741BBE12"
 C%3A%2FData%2FDocuments%2FPersonal%2FCV-first-repo-master%2FCV_with_Symb.Rmd="F9AC1C83"
 C%3A%2FData%2FDocuments%2FPersonal%2FCV-first-repo-master%2Fr%2Fdata_withPatent.r="13B7D63B"
 C%3A%2FData%2FDocuments%2FPersonal%2FRaj.Rmd="705F1BC2"
@@ -52,6 +54,8 @@ C%3A%2FUsers%2FBhosaleS%2FDownloads%2Ftest.qmd="78FF969D"
 ~%2FGitHub%2Fsantoshdbhosale.github.io%2Fblog%2FMass-Spectrometry-Based-Serum-Proteomics%2Findex.qmd="02BE7E08"
 ~%2FGitHub%2Fsantoshdbhosale.github.io%2Fblog%2FProteomics-data-analysis-%26-visualization%2Findex.qmd="C449BE20"
 ~%2FGitHub%2Fsantoshdbhosale.github.io%2Fblog%2FSerum-Proteomics-Atherosclerosis%2Findex.qmd="32BB9D5A"
+~%2FGitHub%2Fsantoshdbhosale.github.io%2Fblog%2FSerum-Proteomics-Pre-diabetic%2Ffooter.Rhtml="75320100"
+~%2FGitHub%2Fsantoshdbhosale.github.io%2Fblog%2FSerum-Proteomics-Pre-diabetic%2Ffooter.html="36D7AB51"
 ~%2FGitHub%2Fsantoshdbhosale.github.io%2Fblog%2FSerum-Proteomics-Pre-diabetic%2Findex.qmd="11366684"
 ~%2FGitHub%2Fsantoshdbhosale.github.io%2Fblog%2Findex.qmd="3F79B444"
 ~%2FGitHub%2Fsantoshdbhosale.github.io%2Fcv%2Findex.qmd="179D375C"
diff --git a/.Rproj.user/224B9E6C/sources/session-676a636/049A85A4 b/.Rproj.user/224B9E6C/sources/session-676a636/049A85A4
new file mode 100644
index 0000000..01cab18
--- /dev/null
+++ b/.Rproj.user/224B9E6C/sources/session-676a636/049A85A4
@@ -0,0 +1,31 @@
+{
+    "id": "049A85A4",
+    "path": "~/GitHub/santoshdbhosale.github.io/index.qmd",
+    "project_path": "index.qmd",
+    "type": "quarto_markdown",
+    "hash": "0",
+    "contents": "",
+    "dirty": false,
+    "created": 1712343345139.0,
+    "source_on_save": false,
+    "relative_order": 2,
+    "properties": {
+        "source_window_id": "",
+        "Source": "Source",
+        "cursorPosition": "16,311",
+        "scrollLine": "0",
+        "rmdVisualMode": "false",
+        "rmdVisualWrapConfigured": "true",
+        "docOutlineVisible": "0",
+        "rmdVisualCollapsedChunks": "",
+        "rmdVisualModeLocation": "82:0"
+    },
+    "folds": "",
+    "lastKnownWriteTime": 1712343898,
+    "encoding": "UTF-8",
+    "collab_server": "",
+    "source_window": "",
+    "last_content_update": 1712343898749,
+    "read_only": false,
+    "read_only_alternatives": []
+}
\ No newline at end of file
diff --git a/.Rproj.user/224B9E6C/sources/session-676a636/049A85A4-contents b/.Rproj.user/224B9E6C/sources/session-676a636/049A85A4-contents
new file mode 100644
index 0000000..29d1106
--- /dev/null
+++ b/.Rproj.user/224B9E6C/sources/session-676a636/049A85A4-contents
@@ -0,0 +1,22 @@
+---
+about:
+  template: jolla
+  id: about-block
+  image: "img/SDB1.jpg"
+---
+
+::: {#about-block}
+:::
+
+# Understanding the Complexity of Proteome!
+
+Hi, I'm Santosh D. Bhosale, pharmacist by training and currently working as an associate biomedical scientist at **[Cedars-Sinai Precision biomarker laboratories](https://www.cs-pbl.com/)**, Los Angeles, CA, USA.
+
+Using the versatility of mass spectrometry-based proteomics, I am exploring the properties of biologically important proteins.
+
+Precisely, I work on mass spectrometry-based proteomics technologies to address the questions related to biomedical research. These includes not only the qualitative and quantitative measurement of proteins, but also their post-translational modifications and interactions with other proteins. I use variety of computational methods to understand the complexity of proteins.
+
+![](img/Proteomics.png){}
+
+
+
diff --git a/.Rproj.user/224B9E6C/sources/session-b2b5d935/lock_file b/.Rproj.user/224B9E6C/sources/session-676a636/lock_file
similarity index 100%
rename from .Rproj.user/224B9E6C/sources/session-b2b5d935/lock_file
rename to .Rproj.user/224B9E6C/sources/session-676a636/lock_file
diff --git a/.Rproj.user/224B9E6C/sources/session-b2b5d935/249EDE74-contents b/.Rproj.user/224B9E6C/sources/session-b2b5d935/249EDE74-contents
deleted file mode 100644
index cf5ed42..0000000
--- a/.Rproj.user/224B9E6C/sources/session-b2b5d935/249EDE74-contents
+++ /dev/null
@@ -1,8 +0,0 @@
----
-title: "Untitled"
-editor: visual
----
-
-quarto install extension quarto-ext/fontawesome
-
-quarto install extension schochastics/academicons
diff --git a/.Rproj.user/224B9E6C/sources/session-b2b5d935/B823F555-contents b/.Rproj.user/224B9E6C/sources/session-b2b5d935/B823F555-contents
deleted file mode 100644
index 3136c44..0000000
--- a/.Rproj.user/224B9E6C/sources/session-b2b5d935/B823F555-contents
+++ /dev/null
@@ -1,4 +0,0 @@
-install.packages('rmarkdown')
-library(rmarkdown)
-packageVersion('rmarkdown')
-
diff --git a/.Rproj.user/224B9E6C/sources/session-b2b5d935/E4BC5B75 b/.Rproj.user/224B9E6C/sources/session-b2b5d935/E4BC5B75
deleted file mode 100644
index 9a30367..0000000
--- a/.Rproj.user/224B9E6C/sources/session-b2b5d935/E4BC5B75
+++ /dev/null
@@ -1,27 +0,0 @@
-{
-    "id": "E4BC5B75",
-    "path": null,
-    "project_path": null,
-    "type": "r_source",
-    "hash": "0",
-    "contents": "",
-    "dirty": true,
-    "created": 1709324989004.0,
-    "source_on_save": false,
-    "relative_order": 1,
-    "properties": {
-        "tempName": "Untitled1",
-        "source_window_id": "",
-        "Source": "Source",
-        "cursorPosition": "2,66",
-        "scrollLine": "0"
-    },
-    "folds": "",
-    "lastKnownWriteTime": 2322280117112693601,
-    "encoding": "",
-    "collab_server": "",
-    "source_window": "",
-    "last_content_update": 1709325009666,
-    "read_only": false,
-    "read_only_alternatives": []
-}
\ No newline at end of file
diff --git a/.Rproj.user/224B9E6C/sources/session-b2b5d935/E4BC5B75-contents b/.Rproj.user/224B9E6C/sources/session-b2b5d935/E4BC5B75-contents
deleted file mode 100644
index 69c3c29..0000000
--- a/.Rproj.user/224B9E6C/sources/session-b2b5d935/E4BC5B75-contents
+++ /dev/null
@@ -1,3 +0,0 @@
-- icon: files
-text: Google-scholar
-href: https://scholar.google.com/citations?user=sIxWbx0AAAAJ&hl=en
\ No newline at end of file
diff --git a/.Rproj.user/224B9E6C/sources/session-b2b5d935/FF8D8B80 b/.Rproj.user/224B9E6C/sources/session-b2b5d935/FF8D8B80
deleted file mode 100644
index 3ae9c32..0000000
--- a/.Rproj.user/224B9E6C/sources/session-b2b5d935/FF8D8B80
+++ /dev/null
@@ -1,26 +0,0 @@
-{
-    "id": "FF8D8B80",
-    "path": "~/GitHub/santoshdbhosale.github.io/_quarto.yml",
-    "project_path": "_quarto.yml",
-    "type": "yaml",
-    "hash": "353348354",
-    "contents": "",
-    "dirty": false,
-    "created": 1709324996242.0,
-    "source_on_save": false,
-    "relative_order": 2,
-    "properties": {
-        "source_window_id": "",
-        "Source": "Source",
-        "cursorPosition": "30,64",
-        "scrollLine": "27"
-    },
-    "folds": "",
-    "lastKnownWriteTime": 1709335671,
-    "encoding": "UTF-8",
-    "collab_server": "",
-    "source_window": "",
-    "last_content_update": 1709335671574,
-    "read_only": false,
-    "read_only_alternatives": []
-}
\ No newline at end of file
diff --git a/.Rproj.user/224B9E6C/sources/session-b2b5d935/FF8D8B80-contents b/.Rproj.user/224B9E6C/sources/session-b2b5d935/FF8D8B80-contents
deleted file mode 100644
index ad0d19b..0000000
--- a/.Rproj.user/224B9E6C/sources/session-b2b5d935/FF8D8B80-contents
+++ /dev/null
@@ -1,68 +0,0 @@
-# This file controls the settings for your Quarto template from www.marvinschmitt.com
-
-# website settings
-website:
-  title: "Santosh D. Bhosale"                                # Your name
-  description: "I am pharmacist by training and do mass spectrometry based proteomics"   # A brief slogan (optional)
-  image: img/sdb.png
-  
-  
-  
-  # start of the navigation bar at the top of the website
-  navbar:
-    pinned: true
-    logo: /img/logo.png
-    
-    # your sub-pages
-    left:
-      - text: "About"
-        href: about/index.qmd
-      - text: "CV"
-        href: cv/index.qmd
-      - text: "Blog"
-        href: blog/index.qmd
-    
-    # your social media handles
-    right:
-      - icon: linkedin
-        href: https://www.linkedin.com/in/santoshdbhosale/
-      - icon: github
-        href: https://github.com/santoshdbhosale
-      - text: "{{< iconify academicons google-scholar size=1.5em >}}"
-        href: https://scholar.google.com/citations?user=sIxWbx0AAAAJ&hl=en
-      - icon: envelope
-        aria-label: email
-        href: "mailto:santoshdbhosale@gmail.com"  
-  
-  
-
-# Don't touch unless you know what you are doing :) ------------
-  search: 
-    location: navbar
-    type: textbox
-  
-project:
-  type: website
-  output-dir: docs
-
-  preview: 
-    port: 22222
-    browser: true
-    watch-inputs: true
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+{"markdown":{"yaml":{"about":{"template":"jolla","id":"about-block"}},"containsRefs":false,"markdown":"\n\n::: {#about-block}\n:::\n\nI am currently employed as an associate biomedical scientist at Precision biomarker laboratories, Cedars-Sinai Medical Center, Los Angeles, CA, USA.\n\nDuring my postdoctoral fellowship, I worked in Prof. Martin R. Larsen's lab at the University of Southern Denmark on developing a pipeline for identifying post-translationally modified biomarkers in clinical samples.\n\nI pursued my PhD from University of Turku under the joint advisorship of Prof. Riitta Lahesmaa and Dr. Robert Moulder. During the course of studies, I worked on identifying and validating the serum protein biomarkers for type 1 diabetes and carotid atherosclerosis.\n\nBefore enrollment into the PhD study, I gained my first level of research experience with my master thesis in the area of proteomics and mass spectrometry at National Chemical Laboratory (NCL) under the joint supervision of Drs. Mahesh J. Kulkarni and B.Santhakumari, after which I continued as a teacher in college of pharmacy and then as a research assistant again at NCL.\n\n","srcMarkdownNoYaml":"\n\n::: {#about-block}\n:::\n\nI am currently employed as an associate biomedical scientist at Precision biomarker laboratories, Cedars-Sinai Medical Center, Los Angeles, CA, USA.\n\nDuring my postdoctoral fellowship, I worked in Prof. Martin R. Larsen's lab at the University of Southern Denmark on developing a pipeline for identifying post-translationally modified biomarkers in clinical samples.\n\nI pursued my PhD from University of Turku under the joint advisorship of Prof. Riitta Lahesmaa and Dr. Robert Moulder. During the course of studies, I worked on identifying and validating the serum protein biomarkers for type 1 diabetes and carotid atherosclerosis.\n\nBefore enrollment into the PhD study, I gained my first level of research experience with my master thesis in the area of proteomics and mass spectrometry at National Chemical Laboratory (NCL) under the joint supervision of Drs. Mahesh J. Kulkarni and B.Santhakumari, after which I continued as a teacher in college of pharmacy and then as a research assistant again at NCL.\n\n"},"formats":{"html":{"identifier":{"display-name":"HTML","target-format":"html","base-format":"html"},"execute":{"fig-width":7,"fig-height":5,"fig-format":"retina","fig-dpi":96,"df-print":"default","error":false,"eval":true,"cache":null,"freeze":true,"echo":true,"output":true,"warning":true,"include":true,"keep-md":false,"keep-ipynb":false,"ipynb":null,"enabled":null,"daemon":null,"daemon-restart":false,"debug":false,"ipynb-filters":[],"ipynb-shell-interactivity":null,"plotly-connected":true,"engine":"markdown"},"render":{"keep-tex":false,"keep-typ":false,"keep-source":false,"keep-hidden":false,"prefer-html":false,"output-divs":true,"output-ext":"html","fig-align":"default","fig-pos":null,"fig-env":null,"code-fold":"none","code-overflow":"scroll","code-link":true,"code-line-numbers":false,"code-tools":false,"tbl-colwidths":"auto","merge-includes":true,"inline-includes":false,"preserve-yaml":false,"latex-auto-mk":true,"latex-auto-install":true,"latex-clean":true,"latex-min-runs":1,"latex-max-runs":10,"latex-makeindex":"makeindex","latex-makeindex-opts":[],"latex-tlmgr-opts":[],"latex-input-paths":[],"latex-output-dir":null,"link-external-icon":false,"link-external-newwindow":false,"self-contained-math":false,"format-resources":[],"notebook-links":true},"pandoc":{"standalone":true,"wrap":"none","default-image-extension":"png","to":"html","toc":false,"reference-location":"margin","output-file":"index.html"},"language":{"toc-title-document":"Table 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diff --git a/.quarto/idx/blog/AP-MS-to-Study-FOSL-Related-Proteins-Interactome/index.qmd.json b/.quarto/idx/blog/AP-MS-to-Study-FOSL-Related-Proteins-Interactome/index.qmd.json
index 4f6ffc6..0a8d171 100644
--- a/.quarto/idx/blog/AP-MS-to-Study-FOSL-Related-Proteins-Interactome/index.qmd.json
+++ b/.quarto/idx/blog/AP-MS-to-Study-FOSL-Related-Proteins-Interactome/index.qmd.json
@@ -1 +1 @@
-{"title":"AP-MS to Study FOSL Related Proteins Interactome","markdown":{"yaml":{"title":"AP-MS to Study FOSL Related Proteins Interactome","date":"2021-09-16","categories":["publications","T cells"],"image":"fig/FOSL-interactors.png"},"containsRefs":false,"markdown":"\n\nProteins represent the key interacting biomolecules in the complex network within the cell and their interactions are crucial in orchestrating all aspects of life at the molecular level. \nMost biochemical functions are not carried out by a specific protein in isolation but by the multiple protein in associations refereed as a protein-protein interactions (PPIs).\n\nAffinity purification-based mass spectrometry (AP-MS) is a technique of choice in discovering PPIs. These experiments are usually carried out by coupling a bait protein to the protein A or immunoglobulin G (IgG) surfaces or an affinity matrix followed by purification of tagged protein from a cell lysate. \nAdditionally, suitable negative control replicates are mandatorily included to define the non-specific background. The composition of PPIs are then delineated by mass spectrometry analysis. \nThese types of studies are useful in understanding the complicated interplay of proteins inside the cells for generating new hypothesis or may be helpful in placing a specific interactor in a pathway to explain observed phenotypes.\n\n**[We used AP-MS method to study interactome of FOS related proteins (FOSL1 and FOSL2) in human Th17 cells](https://pubs.acs.org/doi/10.1021/acsomega.1c03681).** The fate of Th17 cells is regulated by various transcription factors such as BATF, IRF4 and STAT3. Furthermore, the members of the activator protein (AP-1) family including ATF, FOS and JUN also modulate the differentiation of Th17 cells. \nOf these AP-1 members, FOS related proteins regulates variety of processes such as cancer progression, embryonic development and immune cells signaling. In order to understand how FOS related proteins mediates signaling mechanism in Th17 cells, we performed their interactome analysis.\n\nThe analysis resulted in the identification of 163 and 67 proteins for FOSL1 and FOSL2 respectively. These interactors have passed certain criteria including **[mass spectrometry interaction statistics (MiST) algorithm scores](https://modbase.compbio.ucsf.edu/mist/)** with the matching IgG controls and they were mapped against in house common contaminant detected in related AP-MS experiments. \n\nFurthermore, we validated the interesting binding partners of FOSL1 and FOSL2 by western blotting and parallel reaction monitoring mass spectrometry. The shared interactors between FOSL1 and FOSL2 as depicted in below figure were mapped against the **[STRING database](https://string-db.org/)** to construct a network using **[Cytoscape](https://cytoscape.org/).** \n\n![](fig/FOSL-interactors.png){}\n\nThe gene ontology based molecular functional analysis were performed by **[ClueGO](https://apps.cytoscape.org/apps/cluego)** and **[CluePedia](https://apps.cytoscape.org/apps/cluepedia)** apps built in Cytoscape. \n","srcMarkdownNoYaml":"\n\nProteins represent the key interacting biomolecules in the complex network within the cell and their interactions are crucial in orchestrating all aspects of life at the molecular level. \nMost biochemical functions are not carried out by a specific protein in isolation but by the multiple protein in associations refereed as a protein-protein interactions (PPIs).\n\nAffinity purification-based mass spectrometry (AP-MS) is a technique of choice in discovering PPIs. These experiments are usually carried out by coupling a bait protein to the protein A or immunoglobulin G (IgG) surfaces or an affinity matrix followed by purification of tagged protein from a cell lysate. \nAdditionally, suitable negative control replicates are mandatorily included to define the non-specific background. The composition of PPIs are then delineated by mass spectrometry analysis. \nThese types of studies are useful in understanding the complicated interplay of proteins inside the cells for generating new hypothesis or may be helpful in placing a specific interactor in a pathway to explain observed phenotypes.\n\n**[We used AP-MS method to study interactome of FOS related proteins (FOSL1 and FOSL2) in human Th17 cells](https://pubs.acs.org/doi/10.1021/acsomega.1c03681).** The fate of Th17 cells is regulated by various transcription factors such as BATF, IRF4 and STAT3. Furthermore, the members of the activator protein (AP-1) family including ATF, FOS and JUN also modulate the differentiation of Th17 cells. \nOf these AP-1 members, FOS related proteins regulates variety of processes such as cancer progression, embryonic development and immune cells signaling. In order to understand how FOS related proteins mediates signaling mechanism in Th17 cells, we performed their interactome analysis.\n\nThe analysis resulted in the identification of 163 and 67 proteins for FOSL1 and FOSL2 respectively. These interactors have passed certain criteria including **[mass spectrometry interaction statistics (MiST) algorithm scores](https://modbase.compbio.ucsf.edu/mist/)** with the matching IgG controls and they were mapped against in house common contaminant detected in related AP-MS experiments. \n\nFurthermore, we validated the interesting binding partners of FOSL1 and FOSL2 by western blotting and parallel reaction monitoring mass spectrometry. The shared interactors between FOSL1 and FOSL2 as depicted in below figure were mapped against the **[STRING database](https://string-db.org/)** to construct a network using **[Cytoscape](https://cytoscape.org/).** \n\n![](fig/FOSL-interactors.png){}\n\nThe gene ontology based molecular functional analysis were performed by **[ClueGO](https://apps.cytoscape.org/apps/cluego)** and **[CluePedia](https://apps.cytoscape.org/apps/cluepedia)** apps built in Cytoscape. \n"},"formats":{"html":{"identifier":{"display-name":"HTML","target-format":"html","base-format":"html"},"execute":{"fig-width":7,"fig-height":5,"fig-format":"retina","fig-dpi":96,"df-print":"default","error":false,"eval":true,"cache":null,"freeze":true,"echo":true,"output":true,"warning":true,"include":true,"keep-md":false,"keep-ipynb":false,"ipynb":null,"enabled":null,"daemon":null,"daemon-restart":false,"debug":false,"ipynb-filters":[],"engine":"markdown"},"render":{"keep-tex":false,"keep-source":false,"keep-hidden":false,"prefer-html":false,"output-divs":true,"output-ext":"html","fig-align":"default","fig-pos":null,"fig-env":null,"code-fold":"none","code-overflow":"scroll","code-link":true,"code-line-numbers":false,"code-tools":false,"tbl-colwidths":"auto","merge-includes":true,"inline-includes":false,"preserve-yaml":false,"latex-auto-mk":true,"latex-auto-install":true,"latex-clean":true,"latex-max-runs":10,"latex-makeindex":"makeindex","latex-makeindex-opts":[],"latex-tlmgr-opts":[],"latex-input-paths":[],"latex-output-dir":null,"link-external-icon":false,"link-external-newwindow":false,"self-contained-math":false,"format-resources":[],"notebook-links":true,"format-links":true},"pandoc":{"standalone":true,"wrap":"none","default-image-extension":"png","to":"html","toc":false,"reference-location":"margin","output-file":"index.html"},"language":{"toc-title-document":"Table 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+{"title":"AP-MS to Study FOSL Related Proteins Interactome","markdown":{"yaml":{"title":"AP-MS to Study FOSL Related Proteins Interactome","date":"2021-09-16","categories":["publications","T cells"],"image":"fig/FOSL-interactors.png"},"containsRefs":false,"markdown":"\n\nProteins represent the key interacting biomolecules in the complex network within the cell and their interactions are crucial in orchestrating all aspects of life at the molecular level. \nMost biochemical functions are not carried out by a specific protein in isolation but by the multiple protein in associations refereed as a protein-protein interactions (PPIs).\n\nAffinity purification-based mass spectrometry (AP-MS) is a technique of choice in discovering PPIs. These experiments are usually carried out by coupling a bait protein to the protein A or immunoglobulin G (IgG) surfaces or an affinity matrix followed by purification of tagged protein from a cell lysate. \nAdditionally, suitable negative control replicates are mandatorily included to define the non-specific background. The composition of PPIs are then delineated by mass spectrometry analysis. \nThese types of studies are useful in understanding the complicated interplay of proteins inside the cells for generating new hypothesis or may be helpful in placing a specific interactor in a pathway to explain observed phenotypes.\n\n**[We used AP-MS method to study interactome of FOS related proteins (FOSL1 and FOSL2) in human Th17 cells](https://pubs.acs.org/doi/10.1021/acsomega.1c03681).** The fate of Th17 cells is regulated by various transcription factors such as BATF, IRF4 and STAT3. Furthermore, the members of the activator protein (AP-1) family including ATF, FOS and JUN also modulate the differentiation of Th17 cells. \nOf these AP-1 members, FOS related proteins regulates variety of processes such as cancer progression, embryonic development and immune cells signaling. In order to understand how FOS related proteins mediates signaling mechanism in Th17 cells, we performed their interactome analysis.\n\nThe analysis resulted in the identification of 163 and 67 proteins for FOSL1 and FOSL2 respectively. These interactors have passed certain criteria including **[mass spectrometry interaction statistics (MiST) algorithm scores](https://modbase.compbio.ucsf.edu/mist/)** with the matching IgG controls and they were mapped against in house common contaminant detected in related AP-MS experiments. \n\nFurthermore, we validated the interesting binding partners of FOSL1 and FOSL2 by western blotting and parallel reaction monitoring mass spectrometry. The shared interactors between FOSL1 and FOSL2 as depicted in below figure were mapped against the **[STRING database](https://string-db.org/)** to construct a network using **[Cytoscape](https://cytoscape.org/).** \n\n![](fig/FOSL-interactors.png){}\n\nThe gene ontology based molecular functional analysis were performed by **[ClueGO](https://apps.cytoscape.org/apps/cluego)** and **[CluePedia](https://apps.cytoscape.org/apps/cluepedia)** apps built in Cytoscape. \n","srcMarkdownNoYaml":"\n\nProteins represent the key interacting biomolecules in the complex network within the cell and their interactions are crucial in orchestrating all aspects of life at the molecular level. \nMost biochemical functions are not carried out by a specific protein in isolation but by the multiple protein in associations refereed as a protein-protein interactions (PPIs).\n\nAffinity purification-based mass spectrometry (AP-MS) is a technique of choice in discovering PPIs. These experiments are usually carried out by coupling a bait protein to the protein A or immunoglobulin G (IgG) surfaces or an affinity matrix followed by purification of tagged protein from a cell lysate. \nAdditionally, suitable negative control replicates are mandatorily included to define the non-specific background. The composition of PPIs are then delineated by mass spectrometry analysis. \nThese types of studies are useful in understanding the complicated interplay of proteins inside the cells for generating new hypothesis or may be helpful in placing a specific interactor in a pathway to explain observed phenotypes.\n\n**[We used AP-MS method to study interactome of FOS related proteins (FOSL1 and FOSL2) in human Th17 cells](https://pubs.acs.org/doi/10.1021/acsomega.1c03681).** The fate of Th17 cells is regulated by various transcription factors such as BATF, IRF4 and STAT3. Furthermore, the members of the activator protein (AP-1) family including ATF, FOS and JUN also modulate the differentiation of Th17 cells. \nOf these AP-1 members, FOS related proteins regulates variety of processes such as cancer progression, embryonic development and immune cells signaling. In order to understand how FOS related proteins mediates signaling mechanism in Th17 cells, we performed their interactome analysis.\n\nThe analysis resulted in the identification of 163 and 67 proteins for FOSL1 and FOSL2 respectively. These interactors have passed certain criteria including **[mass spectrometry interaction statistics (MiST) algorithm scores](https://modbase.compbio.ucsf.edu/mist/)** with the matching IgG controls and they were mapped against in house common contaminant detected in related AP-MS experiments. \n\nFurthermore, we validated the interesting binding partners of FOSL1 and FOSL2 by western blotting and parallel reaction monitoring mass spectrometry. The shared interactors between FOSL1 and FOSL2 as depicted in below figure were mapped against the **[STRING database](https://string-db.org/)** to construct a network using **[Cytoscape](https://cytoscape.org/).** \n\n![](fig/FOSL-interactors.png){}\n\nThe gene ontology based molecular functional analysis were performed by **[ClueGO](https://apps.cytoscape.org/apps/cluego)** and **[CluePedia](https://apps.cytoscape.org/apps/cluepedia)** apps built in Cytoscape. 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diff --git a/.quarto/idx/blog/Mass-Spectrometry-Based-Serum-Proteomics/index.qmd.json b/.quarto/idx/blog/Mass-Spectrometry-Based-Serum-Proteomics/index.qmd.json
index 0793f4a..7fd1d9a 100644
--- a/.quarto/idx/blog/Mass-Spectrometry-Based-Serum-Proteomics/index.qmd.json
+++ b/.quarto/idx/blog/Mass-Spectrometry-Based-Serum-Proteomics/index.qmd.json
@@ -1 +1 @@
-{"title":"Mass Spectrometry Based Serum Proteomics","markdown":{"yaml":{"title":"Mass Spectrometry Based Serum Proteomics","date":"2020-11-18","categories":["publications","book chapter"]},"containsRefs":false,"markdown":"\n\nI really like Methods in Molecular Biology book series. They publish step by step protocols with detailed information on materials and methods to carry out the experiment in a reproducible manner. In particular notes section provides useful tip and troubleshooting guide.\n\nWe published a protocol entitled **[Mass Spectrometry-Based Serum Proteomics for Biomarker Discovery and Validation](https://link.springer.com/protocol/10.1007/978-1-4939-7057-5_31).** \nIt presents a workflow detailing sample preparation with and without immunodepletion of high abundant serum/plasma proteins and, LC-MS/MS methodology for discovery and targeted measurements of candidate biomarkers. ","srcMarkdownNoYaml":"\n\nI really like Methods in Molecular Biology book series. They publish step by step protocols with detailed information on materials and methods to carry out the experiment in a reproducible manner. In particular notes section provides useful tip and troubleshooting guide.\n\nWe published a protocol entitled **[Mass Spectrometry-Based Serum Proteomics for Biomarker Discovery and Validation](https://link.springer.com/protocol/10.1007/978-1-4939-7057-5_31).** \nIt presents a workflow detailing sample preparation with and without immunodepletion of high abundant serum/plasma proteins and, LC-MS/MS methodology for discovery and targeted measurements of candidate biomarkers. "},"formats":{"html":{"identifier":{"display-name":"HTML","target-format":"html","base-format":"html"},"execute":{"fig-width":7,"fig-height":5,"fig-format":"retina","fig-dpi":96,"df-print":"default","error":false,"eval":true,"cache":null,"freeze":true,"echo":true,"output":true,"warning":true,"include":true,"keep-md":false,"keep-ipynb":false,"ipynb":null,"enabled":null,"daemon":null,"daemon-restart":false,"debug":false,"ipynb-filters":[],"engine":"markdown"},"render":{"keep-tex":false,"keep-source":false,"keep-hidden":false,"prefer-html":false,"output-divs":true,"output-ext":"html","fig-align":"default","fig-pos":null,"fig-env":null,"code-fold":"none","code-overflow":"scroll","code-link":true,"code-line-numbers":false,"code-tools":false,"tbl-colwidths":"auto","merge-includes":true,"inline-includes":false,"preserve-yaml":false,"latex-auto-mk":true,"latex-auto-install":true,"latex-clean":true,"latex-max-runs":10,"latex-makeindex":"makeindex","latex-makeindex-opts":[],"latex-tlmgr-opts":[],"latex-input-paths":[],"latex-output-dir":null,"link-external-icon":false,"link-external-newwindow":false,"self-contained-math":false,"format-resources":[],"notebook-links":true,"format-links":true},"pandoc":{"standalone":true,"wrap":"none","default-image-extension":"png","to":"html","toc":false,"reference-location":"margin","output-file":"index.html"},"language":{"toc-title-document":"Table 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\ No newline at end of file
+{"title":"Mass Spectrometry Based Serum Proteomics","markdown":{"yaml":{"title":"Mass Spectrometry Based Serum Proteomics","date":"2020-11-18","categories":["publications","book chapter"]},"containsRefs":false,"markdown":"\n\nI really like Methods in Molecular Biology book series. They publish step by step protocols with detailed information on materials and methods to carry out the experiment in a reproducible manner. In particular notes section provides useful tip and troubleshooting guide.\n\nWe published a protocol entitled **[Mass Spectrometry-Based Serum Proteomics for Biomarker Discovery and Validation](https://link.springer.com/protocol/10.1007/978-1-4939-7057-5_31).** \nIt presents a workflow detailing sample preparation with and without immunodepletion of high abundant serum/plasma proteins and, LC-MS/MS methodology for discovery and targeted measurements of candidate biomarkers. ","srcMarkdownNoYaml":"\n\nI really like Methods in Molecular Biology book series. They publish step by step protocols with detailed information on materials and methods to carry out the experiment in a reproducible manner. In particular notes section provides useful tip and troubleshooting guide.\n\nWe published a protocol entitled **[Mass Spectrometry-Based Serum Proteomics for Biomarker Discovery and Validation](https://link.springer.com/protocol/10.1007/978-1-4939-7057-5_31).** \nIt presents a workflow detailing sample preparation with and without immunodepletion of high abundant serum/plasma proteins and, LC-MS/MS methodology for discovery and targeted measurements of candidate biomarkers. "},"formats":{"html":{"identifier":{"display-name":"HTML","target-format":"html","base-format":"html"},"execute":{"fig-width":7,"fig-height":5,"fig-format":"retina","fig-dpi":96,"df-print":"default","error":false,"eval":true,"cache":null,"freeze":true,"echo":true,"output":true,"warning":true,"include":true,"keep-md":false,"keep-ipynb":false,"ipynb":null,"enabled":null,"daemon":null,"daemon-restart":false,"debug":false,"ipynb-filters":[],"ipynb-shell-interactivity":null,"plotly-connected":true,"engine":"markdown"},"render":{"keep-tex":false,"keep-typ":false,"keep-source":false,"keep-hidden":false,"prefer-html":false,"output-divs":true,"output-ext":"html","fig-align":"default","fig-pos":null,"fig-env":null,"code-fold":"none","code-overflow":"scroll","code-link":true,"code-line-numbers":false,"code-tools":false,"tbl-colwidths":"auto","merge-includes":true,"inline-includes":false,"preserve-yaml":false,"latex-auto-mk":true,"latex-auto-install":true,"latex-clean":true,"latex-min-runs":1,"latex-max-runs":10,"latex-makeindex":"makeindex","latex-makeindex-opts":[],"latex-tlmgr-opts":[],"latex-input-paths":[],"latex-output-dir":null,"link-external-icon":false,"link-external-newwindow":false,"self-contained-math":false,"format-resources":[],"notebook-links":true},"pandoc":{"standalone":true,"wrap":"none","default-image-extension":"png","to":"html","toc":false,"reference-location":"margin","output-file":"index.html"},"language":{"toc-title-document":"Table 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diff --git a/.quarto/idx/blog/Proteomics-data-analysis-&-visualization/index.qmd.json b/.quarto/idx/blog/Proteomics-data-analysis-&-visualization/index.qmd.json
index ccb32ca..5c45d0a 100644
--- a/.quarto/idx/blog/Proteomics-data-analysis-&-visualization/index.qmd.json
+++ b/.quarto/idx/blog/Proteomics-data-analysis-&-visualization/index.qmd.json
@@ -1 +1 @@
-{"title":"Proteomics data analysis and _visualization_ (no programming skills..its okay..but)","markdown":{"yaml":{"title":"Proteomics data analysis and _visualization_ (no programming skills..its okay..but)","date":"2023-10-10","categories":["data analysis"]},"containsRefs":false,"markdown":"\n\nMass spectrometry based proteomics is the coolest technique to identify and characterize the proteins (including their interaction, alternative splicing, post-transnational modifications and more). Introduction and details about the technology are beyond the scope of this blog post, however, readers are recommended to follow the [comprehensive overview of modern proteomics](https://jessegmeyerlab.github.io/proteomics-tutorial/).\n\nTypical shotgun proteomics experiment on representative number of samples results in generation of several gigabytes of mass spectrometry data files. The analysis of such data undergoes following steps.\n\n-   Quality control checks.\n-   Database search and quantitative analysis.\n-   Statistical analysis\n-   Functional annotation analysis\n\nIn this blog post, I will highlight the tools used to process the mass spectrometry data in the\n\n1.  **Quality control checks:** Depending on the mode of LC-MS/MS data acquisition (i.e. either DDA or DIA), there exist plethora of tools to measure QC metrics. However, for the DIA analysis, limited pipelines are available.\n\n    Often times to use the functionality of some tools, users needs to convert the proprietary MS files into generic file format such as mzmL\n\n    *DDA analysis*\n\n    -   [RawMeat](https://proteomicsresource.washington.edu/protocols06/): developed by Vast Scientific gives a quick overview of TIC (total ion chromatogram), charge state distribution, fill time, spray stability and target fill times. The tool is limited to use with Thermo instrument and it is no longer supported.\n    -   [RawBeans](https://bitbucket.org/incpm/prot-qc/downloads/): generates an interactive html report for\n    -   [QuiC ™](https://biognosys.com/software/quic/): Properitary software from Biognosys, supports most of data acquisition mode (SRM, PRM, DIA or DDA) but it requires addition of iRT peptides to the samples.\n","srcMarkdownNoYaml":"\n\nMass spectrometry based proteomics is the coolest technique to identify and characterize the proteins (including their interaction, alternative splicing, post-transnational modifications and more). Introduction and details about the technology are beyond the scope of this blog post, however, readers are recommended to follow the [comprehensive overview of modern proteomics](https://jessegmeyerlab.github.io/proteomics-tutorial/).\n\nTypical shotgun proteomics experiment on representative number of samples results in generation of several gigabytes of mass spectrometry data files. The analysis of such data undergoes following steps.\n\n-   Quality control checks.\n-   Database search and quantitative analysis.\n-   Statistical analysis\n-   Functional annotation analysis\n\nIn this blog post, I will highlight the tools used to process the mass spectrometry data in the\n\n1.  **Quality control checks:** Depending on the mode of LC-MS/MS data acquisition (i.e. either DDA or DIA), there exist plethora of tools to measure QC metrics. However, for the DIA analysis, limited pipelines are available.\n\n    Often times to use the functionality of some tools, users needs to convert the proprietary MS files into generic file format such as mzmL\n\n    *DDA analysis*\n\n    -   [RawMeat](https://proteomicsresource.washington.edu/protocols06/): developed by Vast Scientific gives a quick overview of TIC (total ion chromatogram), charge state distribution, fill time, spray stability and target fill times. The tool is limited to use with Thermo instrument and it is no longer supported.\n    -   [RawBeans](https://bitbucket.org/incpm/prot-qc/downloads/): generates an interactive html report for\n    -   [QuiC ™](https://biognosys.com/software/quic/): Properitary software from Biognosys, supports most of data acquisition mode (SRM, PRM, DIA or DDA) but it requires addition of iRT peptides to the samples.\n"},"formats":{"html":{"identifier":{"display-name":"HTML","target-format":"html","base-format":"html"},"execute":{"fig-width":7,"fig-height":5,"fig-format":"retina","fig-dpi":96,"df-print":"default","error":false,"eval":true,"cache":null,"freeze":true,"echo":true,"output":true,"warning":true,"include":true,"keep-md":false,"keep-ipynb":false,"ipynb":null,"enabled":null,"daemon":null,"daemon-restart":false,"debug":false,"ipynb-filters":[],"engine":"markdown"},"render":{"keep-tex":false,"keep-source":false,"keep-hidden":false,"prefer-html":false,"output-divs":true,"output-ext":"html","fig-align":"default","fig-pos":null,"fig-env":null,"code-fold":"none","code-overflow":"scroll","code-link":true,"code-line-numbers":false,"code-tools":false,"tbl-colwidths":"auto","merge-includes":true,"inline-includes":false,"preserve-yaml":false,"latex-auto-mk":true,"latex-auto-install":true,"latex-clean":true,"latex-max-runs":10,"latex-makeindex":"makeindex","latex-makeindex-opts":[],"latex-tlmgr-opts":[],"latex-input-paths":[],"latex-output-dir":null,"link-external-icon":false,"link-external-newwindow":false,"self-contained-math":false,"format-resources":[],"notebook-links":true,"format-links":true},"pandoc":{"standalone":true,"wrap":"none","default-image-extension":"png","to":"html","toc":false,"reference-location":"margin","output-file":"index.html"},"language":{"toc-title-document":"Table 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navigation","crossref-fig-title":"Figure","crossref-tbl-title":"Table","crossref-lst-title":"Listing","crossref-thm-title":"Theorem","crossref-lem-title":"Lemma","crossref-cor-title":"Corollary","crossref-prp-title":"Proposition","crossref-cnj-title":"Conjecture","crossref-def-title":"Definition","crossref-exm-title":"Example","crossref-exr-title":"Exercise","crossref-ch-prefix":"Chapter","crossref-apx-prefix":"Appendix","crossref-sec-prefix":"Section","crossref-eq-prefix":"Equation","crossref-lof-title":"List of Figures","crossref-lot-title":"List of Tables","crossref-lol-title":"List of Listings","environment-proof-title":"Proof","environment-remark-title":"Remark","environment-solution-title":"Solution","listing-page-order-by":"Order By","listing-page-order-by-default":"Default","listing-page-order-by-date-asc":"Oldest","listing-page-order-by-date-desc":"Newest","listing-page-order-by-number-desc":"High to Low","listing-page-order-by-number-asc":"Low to 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\ No newline at end of file
+{"title":"Proteomics data analysis and _visualization_ (no programming skills..its okay..but)","markdown":{"yaml":{"title":"Proteomics data analysis and _visualization_ (no programming skills..its okay..but)","date":"2023-10-10","categories":["data analysis"]},"containsRefs":false,"markdown":"\n\nMass spectrometry based proteomics is the coolest technique to identify and characterize the proteins (including their interaction, alternative splicing, post-transnational modifications and more). Introduction and details about the technology are beyond the scope of this blog post, however, readers are recommended to follow the [comprehensive overview of modern proteomics](https://jessegmeyerlab.github.io/proteomics-tutorial/).\n\nTypical shotgun proteomics experiment on representative number of samples results in generation of several gigabytes of mass spectrometry data files. The analysis of such data undergoes following steps.\n\n-   Quality control checks.\n-   Database search and quantitative analysis.\n-   Statistical analysis\n-   Functional annotation analysis\n\nIn this blog post, I will highlight the tools used to process the mass spectrometry data in the\n\n1.  **Quality control checks:** Depending on the mode of LC-MS/MS data acquisition (i.e. either DDA or DIA), there exist plethora of tools to measure QC metrics. However, for the DIA analysis, limited pipelines are available.\n\n    Often times to use the functionality of some tools, users needs to convert the proprietary MS files into generic file format such as mzmL\n\n    *DDA analysis*\n\n    -   [RawMeat](https://proteomicsresource.washington.edu/protocols06/): developed by Vast Scientific gives a quick overview of TIC (total ion chromatogram), charge state distribution, fill time, spray stability and target fill times. The tool is limited to use with Thermo instrument and it is no longer supported.\n    -   [RawBeans](https://bitbucket.org/incpm/prot-qc/downloads/): generates an interactive html report for\n    -   [QuiC ™](https://biognosys.com/software/quic/): Properitary software from Biognosys, supports most of data acquisition mode (SRM, PRM, DIA or DDA) but it requires addition of iRT peptides to the samples.\n","srcMarkdownNoYaml":"\n\nMass spectrometry based proteomics is the coolest technique to identify and characterize the proteins (including their interaction, alternative splicing, post-transnational modifications and more). Introduction and details about the technology are beyond the scope of this blog post, however, readers are recommended to follow the [comprehensive overview of modern proteomics](https://jessegmeyerlab.github.io/proteomics-tutorial/).\n\nTypical shotgun proteomics experiment on representative number of samples results in generation of several gigabytes of mass spectrometry data files. The analysis of such data undergoes following steps.\n\n-   Quality control checks.\n-   Database search and quantitative analysis.\n-   Statistical analysis\n-   Functional annotation analysis\n\nIn this blog post, I will highlight the tools used to process the mass spectrometry data in the\n\n1.  **Quality control checks:** Depending on the mode of LC-MS/MS data acquisition (i.e. either DDA or DIA), there exist plethora of tools to measure QC metrics. However, for the DIA analysis, limited pipelines are available.\n\n    Often times to use the functionality of some tools, users needs to convert the proprietary MS files into generic file format such as mzmL\n\n    *DDA analysis*\n\n    -   [RawMeat](https://proteomicsresource.washington.edu/protocols06/): developed by Vast Scientific gives a quick overview of TIC (total ion chromatogram), charge state distribution, fill time, spray stability and target fill times. The tool is limited to use with Thermo instrument and it is no longer supported.\n    -   [RawBeans](https://bitbucket.org/incpm/prot-qc/downloads/): generates an interactive html report for\n    -   [QuiC ™](https://biognosys.com/software/quic/): Properitary software from Biognosys, supports most of data acquisition mode (SRM, PRM, DIA or DDA) but it requires addition of iRT peptides to the samples.\n"},"formats":{"html":{"identifier":{"display-name":"HTML","target-format":"html","base-format":"html"},"execute":{"fig-width":7,"fig-height":5,"fig-format":"retina","fig-dpi":96,"df-print":"default","error":false,"eval":true,"cache":null,"freeze":true,"echo":true,"output":true,"warning":true,"include":true,"keep-md":false,"keep-ipynb":false,"ipynb":null,"enabled":null,"daemon":null,"daemon-restart":false,"debug":false,"ipynb-filters":[],"ipynb-shell-interactivity":null,"plotly-connected":true,"engine":"markdown"},"render":{"keep-tex":false,"keep-typ":false,"keep-source":false,"keep-hidden":false,"prefer-html":false,"output-divs":true,"output-ext":"html","fig-align":"default","fig-pos":null,"fig-env":null,"code-fold":"none","code-overflow":"scroll","code-link":true,"code-line-numbers":false,"code-tools":false,"tbl-colwidths":"auto","merge-includes":true,"inline-includes":false,"preserve-yaml":false,"latex-auto-mk":true,"latex-auto-install":true,"latex-clean":true,"latex-min-runs":1,"latex-max-runs":10,"latex-makeindex":"makeindex","latex-makeindex-opts":[],"latex-tlmgr-opts":[],"latex-input-paths":[],"latex-output-dir":null,"link-external-icon":false,"link-external-newwindow":false,"self-contained-math":false,"format-resources":[],"notebook-links":true},"pandoc":{"standalone":true,"wrap":"none","default-image-extension":"png","to":"html","toc":false,"reference-location":"margin","output-file":"index.html"},"language":{"toc-title-document":"Table 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citation:","title-block-author-single":"Author","title-block-author-plural":"Authors","title-block-affiliation-single":"Affiliation","title-block-affiliation-plural":"Affiliations","title-block-published":"Published","title-block-modified":"Modified","title-block-keywords":"Keywords","callout-tip-title":"Tip","callout-note-title":"Note","callout-warning-title":"Warning","callout-important-title":"Important","callout-caution-title":"Caution","code-summary":"Code","code-tools-menu-caption":"Code","code-tools-show-all-code":"Show All Code","code-tools-hide-all-code":"Hide All Code","code-tools-view-source":"View Source","code-tools-source-code":"Source Code","tools-share":"Share","tools-download":"Download","code-line":"Line","code-lines":"Lines","copy-button-tooltip":"Copy to Clipboard","copy-button-tooltip-success":"Copied!","repo-action-links-edit":"Edit this page","repo-action-links-source":"View source","repo-action-links-issue":"Report an issue","back-to-top":"Back to 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analysis"]},"extensions":{"book":{"multiFile":true}}}},"projectFormats":["html"]}
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diff --git a/.quarto/idx/blog/Serum-Proteomics-Atherosclerosis/index.qmd.json b/.quarto/idx/blog/Serum-Proteomics-Atherosclerosis/index.qmd.json
index c2f5933..63b460b 100644
--- a/.quarto/idx/blog/Serum-Proteomics-Atherosclerosis/index.qmd.json
+++ b/.quarto/idx/blog/Serum-Proteomics-Atherosclerosis/index.qmd.json
@@ -1 +1 @@
-{"title":"Serum Proteomics Atherosclerosis","markdown":{"yaml":{"title":"Serum Proteomics Atherosclerosis","date":"2020-11-11","categories":["publications","serum"],"image":"fig/roc-plot.png"},"containsRefs":false,"markdown":"\nAtherosclerotic cardiovascular diseases are the major causes of mortality and morbidity in developed world. Thickening of the carotid arterial wall (plaque formation) are indicative of active atherosclerotic process. \nMyocardial infarction and stroke are the clinical events associated with an acute rupture of a critically located atherosclerotic plaque. Currently, ultrasonic assessment of carotid artery intima media thickness is used as a pre-clinical marker of the disease process. \nNevertheless, atherosclerotic process may remain asymptomatic for several decades and whether thickening of intima-media layer of carotid artery and carotid plaque represents two different phenotypes or single traits of disease process is still unclear. \n\nTo gain insights into the pathophysiology of pre-clinical atherosclerosis and identify novel biomarkers, we conducted the **[serum proteomics measurements](https://www.nature.com/articles/s41598-018-27265-9#Sec1) on the unique sample set of participants recruited in [The Cardiovascular Risk in Young Finns Study](https://youngfinnsstudy.utu.fi/studydesign.html).** \nWe performed label free quantitative MS analysis of serum samples obtained from the subjects in whom early signs of plaques were discerned together with matched controls. The serum samples were immunodepleted to remove high abundant proteins prior to LC-MS/MS analysis.\n\nThe profiling results indicated differential abundances in a set of proteins. \nFurthermore, selected reaction monitoring mass spectrometry analysis were performed on undepleted serum samples to verify the observed differences. \nFinally, machine learning analysis identified a panel of three proteins **P23142-4 (Fibulin 1 proteoform C), P02649 (Apolipoprotein E) and P55290 (Cadherin-13)** which segregated the cases from controls with best discrimination (an area under receiver-operating characteristic curve (AUROC) value of 0.79.). \n\n![](fig/roc-plot.png){}\nMore details about the data analysis can be found **[here](https://github.com/santoshdbhosale/Carotid_Atherosclerosis_LFQ).**\n","srcMarkdownNoYaml":"\nAtherosclerotic cardiovascular diseases are the major causes of mortality and morbidity in developed world. Thickening of the carotid arterial wall (plaque formation) are indicative of active atherosclerotic process. \nMyocardial infarction and stroke are the clinical events associated with an acute rupture of a critically located atherosclerotic plaque. Currently, ultrasonic assessment of carotid artery intima media thickness is used as a pre-clinical marker of the disease process. \nNevertheless, atherosclerotic process may remain asymptomatic for several decades and whether thickening of intima-media layer of carotid artery and carotid plaque represents two different phenotypes or single traits of disease process is still unclear. \n\nTo gain insights into the pathophysiology of pre-clinical atherosclerosis and identify novel biomarkers, we conducted the **[serum proteomics measurements](https://www.nature.com/articles/s41598-018-27265-9#Sec1) on the unique sample set of participants recruited in [The Cardiovascular Risk in Young Finns Study](https://youngfinnsstudy.utu.fi/studydesign.html).** \nWe performed label free quantitative MS analysis of serum samples obtained from the subjects in whom early signs of plaques were discerned together with matched controls. The serum samples were immunodepleted to remove high abundant proteins prior to LC-MS/MS analysis.\n\nThe profiling results indicated differential abundances in a set of proteins. \nFurthermore, selected reaction monitoring mass spectrometry analysis were performed on undepleted serum samples to verify the observed differences. \nFinally, machine learning analysis identified a panel of three proteins **P23142-4 (Fibulin 1 proteoform C), P02649 (Apolipoprotein E) and P55290 (Cadherin-13)** which segregated the cases from controls with best discrimination (an area under receiver-operating characteristic curve (AUROC) value of 0.79.). \n\n![](fig/roc-plot.png){}\nMore details about the data analysis can be found **[here](https://github.com/santoshdbhosale/Carotid_Atherosclerosis_LFQ).**\n"},"formats":{"html":{"identifier":{"display-name":"HTML","target-format":"html","base-format":"html"},"execute":{"fig-width":7,"fig-height":5,"fig-format":"retina","fig-dpi":96,"df-print":"default","error":false,"eval":true,"cache":null,"freeze":true,"echo":true,"output":true,"warning":true,"include":true,"keep-md":false,"keep-ipynb":false,"ipynb":null,"enabled":null,"daemon":null,"daemon-restart":false,"debug":false,"ipynb-filters":[],"engine":"markdown"},"render":{"keep-tex":false,"keep-source":false,"keep-hidden":false,"prefer-html":false,"output-divs":true,"output-ext":"html","fig-align":"default","fig-pos":null,"fig-env":null,"code-fold":"none","code-overflow":"scroll","code-link":true,"code-line-numbers":false,"code-tools":false,"tbl-colwidths":"auto","merge-includes":true,"inline-includes":false,"preserve-yaml":false,"latex-auto-mk":true,"latex-auto-install":true,"latex-clean":true,"latex-max-runs":10,"latex-makeindex":"makeindex","latex-makeindex-opts":[],"latex-tlmgr-opts":[],"latex-input-paths":[],"latex-output-dir":null,"link-external-icon":false,"link-external-newwindow":false,"self-contained-math":false,"format-resources":[],"notebook-links":true,"format-links":true},"pandoc":{"standalone":true,"wrap":"none","default-image-extension":"png","to":"html","toc":false,"reference-location":"margin","output-file":"index.html"},"language":{"toc-title-document":"Table 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+{"title":"Serum Proteomics Atherosclerosis","markdown":{"yaml":{"title":"Serum Proteomics Atherosclerosis","date":"2020-11-11","categories":["publications","serum"],"image":"fig/roc-plot.png"},"containsRefs":false,"markdown":"\nAtherosclerotic cardiovascular diseases are the major causes of mortality and morbidity in developed world. Thickening of the carotid arterial wall (plaque formation) are indicative of active atherosclerotic process. \nMyocardial infarction and stroke are the clinical events associated with an acute rupture of a critically located atherosclerotic plaque. Currently, ultrasonic assessment of carotid artery intima media thickness is used as a pre-clinical marker of the disease process. \nNevertheless, atherosclerotic process may remain asymptomatic for several decades and whether thickening of intima-media layer of carotid artery and carotid plaque represents two different phenotypes or single traits of disease process is still unclear. \n\nTo gain insights into the pathophysiology of pre-clinical atherosclerosis and identify novel biomarkers, we conducted the **[serum proteomics measurements](https://www.nature.com/articles/s41598-018-27265-9#Sec1) on the unique sample set of participants recruited in [The Cardiovascular Risk in Young Finns Study](https://youngfinnsstudy.utu.fi/studydesign.html).** \nWe performed label free quantitative MS analysis of serum samples obtained from the subjects in whom early signs of plaques were discerned together with matched controls. The serum samples were immunodepleted to remove high abundant proteins prior to LC-MS/MS analysis.\n\nThe profiling results indicated differential abundances in a set of proteins. \nFurthermore, selected reaction monitoring mass spectrometry analysis were performed on undepleted serum samples to verify the observed differences. \nFinally, machine learning analysis identified a panel of three proteins **P23142-4 (Fibulin 1 proteoform C), P02649 (Apolipoprotein E) and P55290 (Cadherin-13)** which segregated the cases from controls with best discrimination (an area under receiver-operating characteristic curve (AUROC) value of 0.79.). \n\n![](fig/roc-plot.png){}\nMore details about the data analysis can be found **[here](https://github.com/santoshdbhosale/Carotid_Atherosclerosis_LFQ).**\n","srcMarkdownNoYaml":"\nAtherosclerotic cardiovascular diseases are the major causes of mortality and morbidity in developed world. Thickening of the carotid arterial wall (plaque formation) are indicative of active atherosclerotic process. \nMyocardial infarction and stroke are the clinical events associated with an acute rupture of a critically located atherosclerotic plaque. Currently, ultrasonic assessment of carotid artery intima media thickness is used as a pre-clinical marker of the disease process. \nNevertheless, atherosclerotic process may remain asymptomatic for several decades and whether thickening of intima-media layer of carotid artery and carotid plaque represents two different phenotypes or single traits of disease process is still unclear. \n\nTo gain insights into the pathophysiology of pre-clinical atherosclerosis and identify novel biomarkers, we conducted the **[serum proteomics measurements](https://www.nature.com/articles/s41598-018-27265-9#Sec1) on the unique sample set of participants recruited in [The Cardiovascular Risk in Young Finns Study](https://youngfinnsstudy.utu.fi/studydesign.html).** \nWe performed label free quantitative MS analysis of serum samples obtained from the subjects in whom early signs of plaques were discerned together with matched controls. The serum samples were immunodepleted to remove high abundant proteins prior to LC-MS/MS analysis.\n\nThe profiling results indicated differential abundances in a set of proteins. \nFurthermore, selected reaction monitoring mass spectrometry analysis were performed on undepleted serum samples to verify the observed differences. \nFinally, machine learning analysis identified a panel of three proteins **P23142-4 (Fibulin 1 proteoform C), P02649 (Apolipoprotein E) and P55290 (Cadherin-13)** which segregated the cases from controls with best discrimination (an area under receiver-operating characteristic curve (AUROC) value of 0.79.). \n\n![](fig/roc-plot.png){}\nMore details about the data analysis can be found **[here](https://github.com/santoshdbhosale/Carotid_Atherosclerosis_LFQ).**\n"},"formats":{"html":{"identifier":{"display-name":"HTML","target-format":"html","base-format":"html"},"execute":{"fig-width":7,"fig-height":5,"fig-format":"retina","fig-dpi":96,"df-print":"default","error":false,"eval":true,"cache":null,"freeze":true,"echo":true,"output":true,"warning":true,"include":true,"keep-md":false,"keep-ipynb":false,"ipynb":null,"enabled":null,"daemon":null,"daemon-restart":false,"debug":false,"ipynb-filters":[],"ipynb-shell-interactivity":null,"plotly-connected":true,"engine":"markdown"},"render":{"keep-tex":false,"keep-typ":false,"keep-source":false,"keep-hidden":false,"prefer-html":false,"output-divs":true,"output-ext":"html","fig-align":"default","fig-pos":null,"fig-env":null,"code-fold":"none","code-overflow":"scroll","code-link":true,"code-line-numbers":false,"code-tools":false,"tbl-colwidths":"auto","merge-includes":true,"inline-includes":false,"preserve-yaml":false,"latex-auto-mk":true,"latex-auto-install":true,"latex-clean":true,"latex-min-runs":1,"latex-max-runs":10,"latex-makeindex":"makeindex","latex-makeindex-opts":[],"latex-tlmgr-opts":[],"latex-input-paths":[],"latex-output-dir":null,"link-external-icon":false,"link-external-newwindow":false,"self-contained-math":false,"format-resources":[],"notebook-links":true},"pandoc":{"standalone":true,"wrap":"none","default-image-extension":"png","to":"html","toc":false,"reference-location":"margin","output-file":"index.html"},"language":{"toc-title-document":"Table 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citation:","title-block-author-single":"Author","title-block-author-plural":"Authors","title-block-affiliation-single":"Affiliation","title-block-affiliation-plural":"Affiliations","title-block-published":"Published","title-block-modified":"Modified","title-block-keywords":"Keywords","callout-tip-title":"Tip","callout-note-title":"Note","callout-warning-title":"Warning","callout-important-title":"Important","callout-caution-title":"Caution","code-summary":"Code","code-tools-menu-caption":"Code","code-tools-show-all-code":"Show All Code","code-tools-hide-all-code":"Hide All Code","code-tools-view-source":"View Source","code-tools-source-code":"Source Code","tools-share":"Share","tools-download":"Download","code-line":"Line","code-lines":"Lines","copy-button-tooltip":"Copy to Clipboard","copy-button-tooltip-success":"Copied!","repo-action-links-edit":"Edit this page","repo-action-links-source":"View source","repo-action-links-issue":"Report an issue","back-to-top":"Back to 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\ No newline at end of file
diff --git a/.quarto/idx/blog/Serum-Proteomics-Pre-diabetic/index.qmd.json b/.quarto/idx/blog/Serum-Proteomics-Pre-diabetic/index.qmd.json
index 1308a93..989b5ce 100644
--- a/.quarto/idx/blog/Serum-Proteomics-Pre-diabetic/index.qmd.json
+++ b/.quarto/idx/blog/Serum-Proteomics-Pre-diabetic/index.qmd.json
@@ -1 +1 @@
-{"title":"Serum Proteomics Pre diabetic","markdown":{"yaml":{"title":"Serum Proteomics Pre diabetic","date":"2020-10-27","categories":["publications","serum"]},"containsRefs":false,"markdown":"\n\nType-1 diabetes (T1D) is an autoimmune disease that is characterized by the destruction of the insulin producing β cells in the Islets of Langerhans of the pancreas. Currently the measurement of autoantibodies (Aabs) like islet-cell autoantibodies, protein tyrosine phosphatase, glutamic acid decarboxylase, insulin and zinc transporter Slc30A8 protein indicates the manifestation of β cells autoimmunity and increased disease risk. However, the destruction of β cells usually starts early in life and symptoms appears when 90% of the cells are destroyed. The time period of appearance of first Aabs to the onset of the clinical disease can vary from 1 month to over 10 years, moreover, not all Aab positive subjects develop T1D. Thus additional indicators of early disease process and progression are needed. To identify disease associated changes, a careful selection of study group is essential such as **The Finnish Type-1 Diabetes Prediction and Prevention project [DIPP](https://dipp.fi/?page_id=5239&lang=en)** has initiated in 1994. The DIPP cohort has collected blood serum samples at 3 to 6 months intervals from children with a genetically conferred T1D risk and tested for T1D associated autoantibodies. **These longitudinal series of samples cover all the stages of disease progression from birth to clinical T1D and matching samples from carefully matched healthy children.**\n\nWe utilized such unique samples from the DIPP cohort to identify early serum protein biomarkers associated with T1D using quantitative mass spectrometry based approach. The study involved LC-MS/MS analysis with both iTRAQ and label-free quantification strategy on the immunodepleted serum.\n\nPrevious serum proteomics biomarker studies of T1D have typically compared disease end points with control groups, i.e. the differences between patients with T1D and healthy controls. In contrast to the published reports, to our knowledge we have shown for the **[first time serum proteomics profile of pre-diabetic children](https://diabetes.diabetesjournals.org/content/64/6/2265)**, mapping the changes from early infancy, seroconversion and diagnosis. The main finding included lower and higher levels of APOC4 and AFAM in cases compared to controls respectively and, the combination of this two proteins classified T1D developing children from controls with 91% success rate with an area under the curve value of 0.85. Notably the levels of APOC4 were found to be lower even before seroconversion.\n","srcMarkdownNoYaml":"\n\nType-1 diabetes (T1D) is an autoimmune disease that is characterized by the destruction of the insulin producing β cells in the Islets of Langerhans of the pancreas. Currently the measurement of autoantibodies (Aabs) like islet-cell autoantibodies, protein tyrosine phosphatase, glutamic acid decarboxylase, insulin and zinc transporter Slc30A8 protein indicates the manifestation of β cells autoimmunity and increased disease risk. However, the destruction of β cells usually starts early in life and symptoms appears when 90% of the cells are destroyed. The time period of appearance of first Aabs to the onset of the clinical disease can vary from 1 month to over 10 years, moreover, not all Aab positive subjects develop T1D. Thus additional indicators of early disease process and progression are needed. To identify disease associated changes, a careful selection of study group is essential such as **The Finnish Type-1 Diabetes Prediction and Prevention project [DIPP](https://dipp.fi/?page_id=5239&lang=en)** has initiated in 1994. The DIPP cohort has collected blood serum samples at 3 to 6 months intervals from children with a genetically conferred T1D risk and tested for T1D associated autoantibodies. **These longitudinal series of samples cover all the stages of disease progression from birth to clinical T1D and matching samples from carefully matched healthy children.**\n\nWe utilized such unique samples from the DIPP cohort to identify early serum protein biomarkers associated with T1D using quantitative mass spectrometry based approach. The study involved LC-MS/MS analysis with both iTRAQ and label-free quantification strategy on the immunodepleted serum.\n\nPrevious serum proteomics biomarker studies of T1D have typically compared disease end points with control groups, i.e. the differences between patients with T1D and healthy controls. In contrast to the published reports, to our knowledge we have shown for the **[first time serum proteomics profile of pre-diabetic children](https://diabetes.diabetesjournals.org/content/64/6/2265)**, mapping the changes from early infancy, seroconversion and diagnosis. The main finding included lower and higher levels of APOC4 and AFAM in cases compared to controls respectively and, the combination of this two proteins classified T1D developing children from controls with 91% success rate with an area under the curve value of 0.85. Notably the levels of APOC4 were found to be lower even before seroconversion.\n"},"formats":{"html":{"identifier":{"display-name":"HTML","target-format":"html","base-format":"html"},"execute":{"fig-width":7,"fig-height":5,"fig-format":"retina","fig-dpi":96,"df-print":"default","error":false,"eval":true,"cache":null,"freeze":true,"echo":true,"output":true,"warning":true,"include":true,"keep-md":false,"keep-ipynb":false,"ipynb":null,"enabled":null,"daemon":null,"daemon-restart":false,"debug":false,"ipynb-filters":[],"engine":"markdown"},"render":{"keep-tex":false,"keep-source":false,"keep-hidden":false,"prefer-html":false,"output-divs":true,"output-ext":"html","fig-align":"default","fig-pos":null,"fig-env":null,"code-fold":"none","code-overflow":"scroll","code-link":true,"code-line-numbers":false,"code-tools":false,"tbl-colwidths":"auto","merge-includes":true,"inline-includes":false,"preserve-yaml":false,"latex-auto-mk":true,"latex-auto-install":true,"latex-clean":true,"latex-max-runs":10,"latex-makeindex":"makeindex","latex-makeindex-opts":[],"latex-tlmgr-opts":[],"latex-input-paths":[],"latex-output-dir":null,"link-external-icon":false,"link-external-newwindow":false,"self-contained-math":false,"format-resources":[],"notebook-links":true,"format-links":true},"pandoc":{"standalone":true,"wrap":"none","default-image-extension":"png","to":"html","toc":false,"reference-location":"margin","output-file":"index.html"},"language":{"toc-title-document":"Table 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\ No newline at end of file
+{"title":"Serum Proteomics Pre diabetic","markdown":{"yaml":{"title":"Serum Proteomics Pre diabetic","date":"2020-10-27","categories":["publications","serum"]},"containsRefs":false,"markdown":"\n\nType-1 diabetes (T1D) is an autoimmune disease that is characterized by the destruction of the insulin producing β cells in the Islets of Langerhans of the pancreas. Currently the measurement of autoantibodies (Aabs) like islet-cell autoantibodies, protein tyrosine phosphatase, glutamic acid decarboxylase, insulin and zinc transporter Slc30A8 protein indicates the manifestation of β cells autoimmunity and increased disease risk. However, the destruction of β cells usually starts early in life and symptoms appears when 90% of the cells are destroyed. The time period of appearance of first Aabs to the onset of the clinical disease can vary from 1 month to over 10 years, moreover, not all Aab positive subjects develop T1D. Thus additional indicators of early disease process and progression are needed. To identify disease associated changes, a careful selection of study group is essential such as **The Finnish Type-1 Diabetes Prediction and Prevention project [DIPP](https://dipp.fi/?page_id=5239&lang=en)** has initiated in 1994. The DIPP cohort has collected blood serum samples at 3 to 6 months intervals from children with a genetically conferred T1D risk and tested for T1D associated autoantibodies. **These longitudinal series of samples cover all the stages of disease progression from birth to clinical T1D and matching samples from carefully matched healthy children.**\n\nWe utilized such unique samples from the DIPP cohort to identify early serum protein biomarkers associated with T1D using quantitative mass spectrometry based approach. The study involved LC-MS/MS analysis with both iTRAQ and label-free quantification strategy on the immunodepleted serum.\n\nPrevious serum proteomics biomarker studies of T1D have typically compared disease end points with control groups, i.e. the differences between patients with T1D and healthy controls. In contrast to the published reports, to our knowledge we have shown for the **[first time serum proteomics profile of pre-diabetic children](https://diabetes.diabetesjournals.org/content/64/6/2265)**, mapping the changes from early infancy, seroconversion and diagnosis. The main finding included lower and higher levels of APOC4 and AFAM in cases compared to controls respectively and, the combination of this two proteins classified T1D developing children from controls with 91% success rate with an area under the curve value of 0.85. Notably the levels of APOC4 were found to be lower even before seroconversion.\n","srcMarkdownNoYaml":"\n\nType-1 diabetes (T1D) is an autoimmune disease that is characterized by the destruction of the insulin producing β cells in the Islets of Langerhans of the pancreas. Currently the measurement of autoantibodies (Aabs) like islet-cell autoantibodies, protein tyrosine phosphatase, glutamic acid decarboxylase, insulin and zinc transporter Slc30A8 protein indicates the manifestation of β cells autoimmunity and increased disease risk. However, the destruction of β cells usually starts early in life and symptoms appears when 90% of the cells are destroyed. The time period of appearance of first Aabs to the onset of the clinical disease can vary from 1 month to over 10 years, moreover, not all Aab positive subjects develop T1D. Thus additional indicators of early disease process and progression are needed. To identify disease associated changes, a careful selection of study group is essential such as **The Finnish Type-1 Diabetes Prediction and Prevention project [DIPP](https://dipp.fi/?page_id=5239&lang=en)** has initiated in 1994. The DIPP cohort has collected blood serum samples at 3 to 6 months intervals from children with a genetically conferred T1D risk and tested for T1D associated autoantibodies. **These longitudinal series of samples cover all the stages of disease progression from birth to clinical T1D and matching samples from carefully matched healthy children.**\n\nWe utilized such unique samples from the DIPP cohort to identify early serum protein biomarkers associated with T1D using quantitative mass spectrometry based approach. The study involved LC-MS/MS analysis with both iTRAQ and label-free quantification strategy on the immunodepleted serum.\n\nPrevious serum proteomics biomarker studies of T1D have typically compared disease end points with control groups, i.e. the differences between patients with T1D and healthy controls. In contrast to the published reports, to our knowledge we have shown for the **[first time serum proteomics profile of pre-diabetic children](https://diabetes.diabetesjournals.org/content/64/6/2265)**, mapping the changes from early infancy, seroconversion and diagnosis. The main finding included lower and higher levels of APOC4 and AFAM in cases compared to controls respectively and, the combination of this two proteins classified T1D developing children from controls with 91% success rate with an area under the curve value of 0.85. Notably the levels of APOC4 were found to be lower even before seroconversion.\n"},"formats":{"html":{"identifier":{"display-name":"HTML","target-format":"html","base-format":"html"},"execute":{"fig-width":7,"fig-height":5,"fig-format":"retina","fig-dpi":96,"df-print":"default","error":false,"eval":true,"cache":null,"freeze":true,"echo":true,"output":true,"warning":true,"include":true,"keep-md":false,"keep-ipynb":false,"ipynb":null,"enabled":null,"daemon":null,"daemon-restart":false,"debug":false,"ipynb-filters":[],"ipynb-shell-interactivity":null,"plotly-connected":true,"engine":"markdown"},"render":{"keep-tex":false,"keep-typ":false,"keep-source":false,"keep-hidden":false,"prefer-html":false,"output-divs":true,"output-ext":"html","fig-align":"default","fig-pos":null,"fig-env":null,"code-fold":"none","code-overflow":"scroll","code-link":true,"code-line-numbers":false,"code-tools":false,"tbl-colwidths":"auto","merge-includes":true,"inline-includes":false,"preserve-yaml":false,"latex-auto-mk":true,"latex-auto-install":true,"latex-clean":true,"latex-min-runs":1,"latex-max-runs":10,"latex-makeindex":"makeindex","latex-makeindex-opts":[],"latex-tlmgr-opts":[],"latex-input-paths":[],"latex-output-dir":null,"link-external-icon":false,"link-external-newwindow":false,"self-contained-math":false,"format-resources":[],"notebook-links":true},"pandoc":{"standalone":true,"wrap":"none","default-image-extension":"png","to":"html","toc":false,"reference-location":"margin","output-file":"index.html"},"language":{"toc-title-document":"Table 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\ No newline at end of file
diff --git a/.quarto/idx/blog/index.qmd.json b/.quarto/idx/blog/index.qmd.json
index d048d53..dcafea1 100644
--- a/.quarto/idx/blog/index.qmd.json
+++ b/.quarto/idx/blog/index.qmd.json
@@ -1 +1 @@
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diff --git a/.quarto/idx/cv/index.qmd.json b/.quarto/idx/cv/index.qmd.json
index 8003573..48232d8 100644
--- a/.quarto/idx/cv/index.qmd.json
+++ b/.quarto/idx/cv/index.qmd.json
@@ -1 +1 @@
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echo=FALSE}\n.embed-container {\n    position: relative;\n    padding-bottom: 129%;\n    height: 0;\n    overflow: hidden;\n    max-width: 100%;\n}\n.embed-container iframe,\n.embed-container object,\n.embed-container embed {\n    position: absolute;\n    top: 0;\n    left: 0;\n    width: 100%;\n    height: 100%;\n}\n```\n\n```{=html}\n<p class=\"text-center\">\n  <a class=\"btn btn-primary btn-lg cv-download\" href=\"`r rmarkdown::metadata$cv$pdf`\" target=\"_blank\">\n    <i class=\"fa-solid fa-file-arrow-down\"></i>&ensp;Download current CV\n  </a>\n</p>\n<div class=\"embed-container\">\n  <iframe src=\"`r rmarkdown::metadata$cv$pdf`\" style=\"border: 0.5px\"></iframe>\n</div>\n```\n\n\n"},"formats":{"html":{"identifier":{"display-name":"HTML","target-format":"html","base-format":"html"},"execute":{"fig-width":7,"fig-height":5,"fig-format":"retina","fig-dpi":96,"df-print":"default","error":false,"eval":true,"cache":null,"freeze":true,"echo":true,"output":true,"warning":true,"include":true,"keep-md":false,"keep-ipynb":false,"ipynb":null,"enabled":null,"daemon":null,"daemon-restart":false,"debug":false,"ipynb-filters":[],"engine":"knitr"},"render":{"keep-tex":false,"keep-source":false,"keep-hidden":false,"prefer-html":false,"output-divs":true,"output-ext":"html","fig-align":"default","fig-pos":null,"fig-env":null,"code-fold":"none","code-overflow":"scroll","code-link":true,"code-line-numbers":false,"code-tools":false,"tbl-colwidths":"auto","merge-includes":true,"inline-includes":false,"preserve-yaml":false,"latex-auto-mk":true,"latex-auto-install":true,"latex-clean":true,"latex-max-runs":10,"latex-makeindex":"makeindex","latex-makeindex-opts":[],"latex-tlmgr-opts":[],"latex-input-paths":[],"latex-output-dir":null,"link-external-icon":false,"link-external-newwindow":false,"self-contained-math":false,"format-resources":[],"notebook-links":true,"format-links":true},"pandoc":{"standalone":true,"wrap":"none","default-image-extension":"png","to":"html","toc":false,"reference-location":"margin","output-file":"index.html"},"language":{"toc-title-document":"Table 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\ No newline at end of file
+{"title":"Curriculum vitae","markdown":{"yaml":{"layout":"page","title":"Curriculum vitae","excerpt":"My current CV","execute":{"freeze":true},"engine":"knitr","resources":["cv.pdf"],"cv":{"pdf":"cv.pdf"}},"containsRefs":false,"markdown":"\n\n```{css echo=FALSE}\n.embed-container {\n    position: relative;\n    padding-bottom: 129%;\n    height: 0;\n    overflow: hidden;\n    max-width: 100%;\n}\n.embed-container iframe,\n.embed-container object,\n.embed-container embed {\n    position: absolute;\n    top: 0;\n    left: 0;\n    width: 100%;\n    height: 100%;\n}\n```\n\n```{=html}\n<p class=\"text-center\">\n  <a class=\"btn btn-primary btn-lg cv-download\" href=\"`r rmarkdown::metadata$cv$pdf`\" target=\"_blank\">\n    <i class=\"fa-solid fa-file-arrow-down\"></i>&ensp;Download current CV\n  </a>\n</p>\n<div class=\"embed-container\">\n  <iframe src=\"`r rmarkdown::metadata$cv$pdf`\" style=\"border: 0.5px\"></iframe>\n</div>\n```\n\n\n","srcMarkdownNoYaml":"\n\n```{css 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diff --git a/blog/index.qmd b/blog/index.qmd
index 99b0d52..040e23a 100644
--- a/blog/index.qmd
+++ b/blog/index.qmd
@@ -23,5 +23,4 @@ Welcome to my blog, here, you will find a collection of posts for some of the pr
 
 The snapshot of my research work is visualized in the following WordCloud using [Scholar Googler](https://shiny.rcg.sfu.ca/u/rdmorin/scholar_googler3/) shiny app. This app extracts information from research publications by using individual's Google Scholar ID.
 
-
 ![](/img/wordcloud.png){width="500"}
diff --git a/docs/404.html b/docs/404.html
index 9c5bf5a..7e88a5e 100644
--- a/docs/404.html
+++ b/docs/404.html
@@ -2,7 +2,7 @@
 <html xmlns="http://www.w3.org/1999/xhtml" lang="en" xml:lang="en"><head>
 
 <meta charset="utf-8">
-<meta name="generator" content="quarto-1.3.450">
+<meta name="generator" content="quarto-1.4.553">
 
 <meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
 
@@ -45,7 +45,12 @@
   "collapse-after": 3,
   "panel-placement": "end",
   "type": "textbox",
-  "limit": 20,
+  "limit": 50,
+  "keyboard-shortcut": [
+    "f",
+    "/",
+    "s"
+  ],
   "language": {
     "search-no-results-text": "No results",
     "search-matching-documents-text": "matching documents",
@@ -54,6 +59,7 @@
     "search-more-match-text": "more match in this document",
     "search-more-matches-text": "more matches in this document",
     "search-clear-button-title": "Clear",
+    "search-text-placeholder": "",
     "search-detached-cancel-button-title": "Cancel",
     "search-submit-button-title": "Submit",
     "search-label": "Search"
@@ -67,9 +73,9 @@
 
 <div id="quarto-search-results"></div>
   <header id="quarto-header" class="headroom fixed-top">
-    <nav class="navbar navbar-expand-lg navbar-dark ">
+    <nav class="navbar navbar-expand-lg " data-bs-theme="dark">
       <div class="navbar-container container-fluid">
-      <div class="navbar-brand-container">
+      <div class="navbar-brand-container mx-auto">
     <a href="/index.html" class="navbar-brand navbar-brand-logo">
     <img src="/img/logo.png" alt="" class="navbar-logo">
     </a>
@@ -84,42 +90,42 @@
           <div class="collapse navbar-collapse" id="navbarCollapse">
             <ul class="navbar-nav navbar-nav-scroll me-auto">
   <li class="nav-item">
-    <a class="nav-link" href="/about/index.html" rel="" target="">
- <span class="menu-text">About</span></a>
+    <a class="nav-link" href="/about/index.html"> 
+<span class="menu-text">About</span></a>
   </li>  
   <li class="nav-item">
-    <a class="nav-link" href="/cv/index.html" rel="" target="">
- <span class="menu-text">CV</span></a>
+    <a class="nav-link" href="/cv/index.html"> 
+<span class="menu-text">CV</span></a>
   </li>  
   <li class="nav-item">
-    <a class="nav-link" href="/blog/index.html" rel="" target="">
- <span class="menu-text">Blog</span></a>
+    <a class="nav-link" href="/blog/index.html"> 
+<span class="menu-text">Blog</span></a>
   </li>  
 </ul>
             <ul class="navbar-nav navbar-nav-scroll ms-auto">
   <li class="nav-item compact">
-    <a class="nav-link" href="https://www.linkedin.com/in/santoshdbhosale/" rel="" target=""><i class="bi bi-linkedin" role="img">
+    <a class="nav-link" href="https://www.linkedin.com/in/santoshdbhosale/"> <i class="bi bi-linkedin" role="img">
 </i> 
- <span class="menu-text"></span></a>
+<span class="menu-text"></span></a>
   </li>  
   <li class="nav-item compact">
-    <a class="nav-link" href="https://github.com/santoshdbhosale" rel="" target=""><i class="bi bi-github" role="img">
+    <a class="nav-link" href="https://github.com/santoshdbhosale"> <i class="bi bi-github" role="img">
 </i> 
- <span class="menu-text"></span></a>
+<span class="menu-text"></span></a>
   </li>  
   <li class="nav-item">
-    <a class="nav-link" href="https://scholar.google.com/citations?user=sIxWbx0AAAAJ&amp;hl=en" rel="" target="">
- <span class="menu-text"><iconify-icon inline="" icon="academicons:google-scholar" style="font-size: 1.5em;"></iconify-icon></span></a>
+    <a class="nav-link" href="https://scholar.google.com/citations?user=sIxWbx0AAAAJ&amp;hl=en"> 
+<span class="menu-text"><iconify-icon inline="" icon="academicons:google-scholar" style="font-size: 1.5em;"></iconify-icon></span></a>
   </li>  
   <li class="nav-item compact">
-    <a class="nav-link" href="mailto:santoshdbhosale@gmail.com" rel="" target=""><i class="bi bi-envelope" role="img" aria-label="email">
+    <a class="nav-link" href="mailto:santoshdbhosale@gmail.com"> <i class="bi bi-envelope" role="img" aria-label="email">
 </i> 
- <span class="menu-text"></span></a>
+<span class="menu-text"></span></a>
   </li>  
 </ul>
-            <div class="quarto-navbar-tools">
-</div>
           </div> <!-- /navcollapse -->
+          <div class="quarto-navbar-tools">
+</div>
       </div> <!-- /container-fluid -->
     </nav>
 </header>
@@ -146,8 +152,10 @@ <h1 class="title">404</h1>
   </div>
   
 
+
 </header>
 
+
 <p>Page not found, sorry! Try the search or navigate back to the base website.</p>
 
 
@@ -232,10 +240,27 @@ <h1 class="title">404</h1>
     // clear code selection
     e.clearSelection();
   });
-  function tippyHover(el, contentFn) {
+    var localhostRegex = new RegExp(/^(?:http|https):\/\/localhost\:?[0-9]*\//);
+    var mailtoRegex = new RegExp(/^mailto:/);
+      var filterRegex = new RegExp('/' + window.location.host + '/');
+    var isInternal = (href) => {
+        return filterRegex.test(href) || localhostRegex.test(href) || mailtoRegex.test(href);
+    }
+    // Inspect non-navigation links and adorn them if external
+ 	var links = window.document.querySelectorAll('a[href]:not(.nav-link):not(.navbar-brand):not(.toc-action):not(.sidebar-link):not(.sidebar-item-toggle):not(.pagination-link):not(.no-external):not([aria-hidden]):not(.dropdown-item):not(.quarto-navigation-tool)');
+    for (var i=0; i<links.length; i++) {
+      const link = links[i];
+      if (!isInternal(link.href)) {
+        // undo the damage that might have been done by quarto-nav.js in the case of
+        // links that we want to consider external
+        if (link.dataset.originalHref !== undefined) {
+          link.href = link.dataset.originalHref;
+        }
+      }
+    }
+  function tippyHover(el, contentFn, onTriggerFn, onUntriggerFn) {
     const config = {
       allowHTML: true,
-      content: contentFn,
       maxWidth: 500,
       delay: 100,
       arrow: false,
@@ -245,8 +270,17 @@ <h1 class="title">404</h1>
       interactive: true,
       interactiveBorder: 10,
       theme: 'quarto',
-      placement: 'bottom-start'
+      placement: 'bottom-start',
     };
+    if (contentFn) {
+      config.content = contentFn;
+    }
+    if (onTriggerFn) {
+      config.onTrigger = onTriggerFn;
+    }
+    if (onUntriggerFn) {
+      config.onUntrigger = onUntriggerFn;
+    }
     window.tippy(el, config); 
   }
   const noterefs = window.document.querySelectorAll('a[role="doc-noteref"]');
@@ -258,7 +292,130 @@ <h1 class="title">404</h1>
       try { href = new URL(href).hash; } catch {}
       const id = href.replace(/^#\/?/, "");
       const note = window.document.getElementById(id);
-      return note.innerHTML;
+      if (note) {
+        return note.innerHTML;
+      } else {
+        return "";
+      }
+    });
+  }
+  const xrefs = window.document.querySelectorAll('a.quarto-xref');
+  const processXRef = (id, note) => {
+    // Strip column container classes
+    const stripColumnClz = (el) => {
+      el.classList.remove("page-full", "page-columns");
+      if (el.children) {
+        for (const child of el.children) {
+          stripColumnClz(child);
+        }
+      }
+    }
+    stripColumnClz(note)
+    if (id === null || id.startsWith('sec-')) {
+      // Special case sections, only their first couple elements
+      const container = document.createElement("div");
+      if (note.children && note.children.length > 2) {
+        container.appendChild(note.children[0].cloneNode(true));
+        for (let i = 1; i < note.children.length; i++) {
+          const child = note.children[i];
+          if (child.tagName === "P" && child.innerText === "") {
+            continue;
+          } else {
+            container.appendChild(child.cloneNode(true));
+            break;
+          }
+        }
+        if (window.Quarto?.typesetMath) {
+          window.Quarto.typesetMath(container);
+        }
+        return container.innerHTML
+      } else {
+        if (window.Quarto?.typesetMath) {
+          window.Quarto.typesetMath(note);
+        }
+        return note.innerHTML;
+      }
+    } else {
+      // Remove any anchor links if they are present
+      const anchorLink = note.querySelector('a.anchorjs-link');
+      if (anchorLink) {
+        anchorLink.remove();
+      }
+      if (window.Quarto?.typesetMath) {
+        window.Quarto.typesetMath(note);
+      }
+      // TODO in 1.5, we should make sure this works without a callout special case
+      if (note.classList.contains("callout")) {
+        return note.outerHTML;
+      } else {
+        return note.innerHTML;
+      }
+    }
+  }
+  for (var i=0; i<xrefs.length; i++) {
+    const xref = xrefs[i];
+    tippyHover(xref, undefined, function(instance) {
+      instance.disable();
+      let url = xref.getAttribute('href');
+      let hash = undefined; 
+      if (url.startsWith('#')) {
+        hash = url;
+      } else {
+        try { hash = new URL(url).hash; } catch {}
+      }
+      if (hash) {
+        const id = hash.replace(/^#\/?/, "");
+        const note = window.document.getElementById(id);
+        if (note !== null) {
+          try {
+            const html = processXRef(id, note.cloneNode(true));
+            instance.setContent(html);
+          } finally {
+            instance.enable();
+            instance.show();
+          }
+        } else {
+          // See if we can fetch this
+          fetch(url.split('#')[0])
+          .then(res => res.text())
+          .then(html => {
+            const parser = new DOMParser();
+            const htmlDoc = parser.parseFromString(html, "text/html");
+            const note = htmlDoc.getElementById(id);
+            if (note !== null) {
+              const html = processXRef(id, note);
+              instance.setContent(html);
+            } 
+          }).finally(() => {
+            instance.enable();
+            instance.show();
+          });
+        }
+      } else {
+        // See if we can fetch a full url (with no hash to target)
+        // This is a special case and we should probably do some content thinning / targeting
+        fetch(url)
+        .then(res => res.text())
+        .then(html => {
+          const parser = new DOMParser();
+          const htmlDoc = parser.parseFromString(html, "text/html");
+          const note = htmlDoc.querySelector('main.content');
+          if (note !== null) {
+            // This should only happen for chapter cross references
+            // (since there is no id in the URL)
+            // remove the first header
+            if (note.children.length > 0 && note.children[0].tagName === "HEADER") {
+              note.children[0].remove();
+            }
+            const html = processXRef(null, note);
+            instance.setContent(html);
+          } 
+        }).finally(() => {
+          instance.enable();
+          instance.show();
+        });
+      }
+    }, function(instance) {
     });
   }
       let selectedAnnoteEl;
@@ -302,6 +459,7 @@ <h1 class="title">404</h1>
             }
             div.style.top = top - 2 + "px";
             div.style.height = height + 4 + "px";
+            div.style.left = 0;
             let gutterDiv = window.document.getElementById("code-annotation-line-highlight-gutter");
             if (gutterDiv === null) {
               gutterDiv = window.document.createElement("div");
@@ -327,6 +485,32 @@ <h1 class="title">404</h1>
         });
         selectedAnnoteEl = undefined;
       };
+        // Handle positioning of the toggle
+    window.addEventListener(
+      "resize",
+      throttle(() => {
+        elRect = undefined;
+        if (selectedAnnoteEl) {
+          selectCodeLines(selectedAnnoteEl);
+        }
+      }, 10)
+    );
+    function throttle(fn, ms) {
+    let throttle = false;
+    let timer;
+      return (...args) => {
+        if(!throttle) { // first call gets through
+            fn.apply(this, args);
+            throttle = true;
+        } else { // all the others get throttled
+            if(timer) clearTimeout(timer); // cancel #2
+            timer = setTimeout(() => {
+              fn.apply(this, args);
+              timer = throttle = false;
+            }, ms);
+        }
+      };
+    }
       // Attach click handler to the DT
       const annoteDls = window.document.querySelectorAll('dt[data-target-cell]');
       for (const annoteDlNode of annoteDls) {
@@ -390,4 +574,5 @@ <h1 class="title">404</h1>
 
 
 
+
 </body></html>
\ No newline at end of file
diff --git a/docs/about/index.html b/docs/about/index.html
index 3083d4c..b938407 100644
--- a/docs/about/index.html
+++ b/docs/about/index.html
@@ -2,12 +2,12 @@
 <html xmlns="http://www.w3.org/1999/xhtml" lang="en" xml:lang="en"><head>
 
 <meta charset="utf-8">
-<meta name="generator" content="quarto-1.3.450">
+<meta name="generator" content="quarto-1.4.553">
 
 <meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
 
 
-<title>Santosh D. Bhosale – index</title>
+<title>Santosh D. Bhosale</title>
 <style>
 code{white-space: pre-wrap;}
 span.smallcaps{font-variant: small-caps;}
@@ -44,7 +44,12 @@
   "collapse-after": 3,
   "panel-placement": "end",
   "type": "textbox",
-  "limit": 20,
+  "limit": 50,
+  "keyboard-shortcut": [
+    "f",
+    "/",
+    "s"
+  ],
   "language": {
     "search-no-results-text": "No results",
     "search-matching-documents-text": "matching documents",
@@ -53,6 +58,7 @@
     "search-more-match-text": "more match in this document",
     "search-more-matches-text": "more matches in this document",
     "search-clear-button-title": "Clear",
+    "search-text-placeholder": "",
     "search-detached-cancel-button-title": "Cancel",
     "search-submit-button-title": "Submit",
     "search-label": "Search"
@@ -66,9 +72,9 @@
 
 <div id="quarto-search-results"></div>
   <header id="quarto-header" class="headroom fixed-top">
-    <nav class="navbar navbar-expand-lg navbar-dark ">
+    <nav class="navbar navbar-expand-lg " data-bs-theme="dark">
       <div class="navbar-container container-fluid">
-      <div class="navbar-brand-container">
+      <div class="navbar-brand-container mx-auto">
     <a href="../index.html" class="navbar-brand navbar-brand-logo">
     <img src="../img/logo.png" alt="" class="navbar-logo">
     </a>
@@ -83,42 +89,42 @@
           <div class="collapse navbar-collapse" id="navbarCollapse">
             <ul class="navbar-nav navbar-nav-scroll me-auto">
   <li class="nav-item">
-    <a class="nav-link active" href="../about/index.html" rel="" target="" aria-current="page">
- <span class="menu-text">About</span></a>
+    <a class="nav-link active" href="../about/index.html" aria-current="page"> 
+<span class="menu-text">About</span></a>
   </li>  
   <li class="nav-item">
-    <a class="nav-link" href="../cv/index.html" rel="" target="">
- <span class="menu-text">CV</span></a>
+    <a class="nav-link" href="../cv/index.html"> 
+<span class="menu-text">CV</span></a>
   </li>  
   <li class="nav-item">
-    <a class="nav-link" href="../blog/index.html" rel="" target="">
- <span class="menu-text">Blog</span></a>
+    <a class="nav-link" href="../blog/index.html"> 
+<span class="menu-text">Blog</span></a>
   </li>  
 </ul>
             <ul class="navbar-nav navbar-nav-scroll ms-auto">
   <li class="nav-item compact">
-    <a class="nav-link" href="https://www.linkedin.com/in/santoshdbhosale/" rel="" target=""><i class="bi bi-linkedin" role="img">
+    <a class="nav-link" href="https://www.linkedin.com/in/santoshdbhosale/"> <i class="bi bi-linkedin" role="img">
 </i> 
- <span class="menu-text"></span></a>
+<span class="menu-text"></span></a>
   </li>  
   <li class="nav-item compact">
-    <a class="nav-link" href="https://github.com/santoshdbhosale" rel="" target=""><i class="bi bi-github" role="img">
+    <a class="nav-link" href="https://github.com/santoshdbhosale"> <i class="bi bi-github" role="img">
 </i> 
- <span class="menu-text"></span></a>
+<span class="menu-text"></span></a>
   </li>  
   <li class="nav-item">
-    <a class="nav-link" href="https://scholar.google.com/citations?user=sIxWbx0AAAAJ&amp;hl=en" rel="" target="">
- <span class="menu-text"><iconify-icon inline="" icon="academicons:google-scholar" style="font-size: 1.5em;"></iconify-icon></span></a>
+    <a class="nav-link" href="https://scholar.google.com/citations?user=sIxWbx0AAAAJ&amp;hl=en"> 
+<span class="menu-text"><iconify-icon inline="" icon="academicons:google-scholar" style="font-size: 1.5em;"></iconify-icon></span></a>
   </li>  
   <li class="nav-item compact">
-    <a class="nav-link" href="mailto:santoshdbhosale@gmail.com" rel="" target=""><i class="bi bi-envelope" role="img" aria-label="email">
+    <a class="nav-link" href="mailto:santoshdbhosale@gmail.com"> <i class="bi bi-envelope" role="img" aria-label="email">
 </i> 
- <span class="menu-text"></span></a>
+<span class="menu-text"></span></a>
   </li>  
 </ul>
-            <div class="quarto-navbar-tools">
-</div>
           </div> <!-- /navcollapse -->
+          <div class="quarto-navbar-tools">
+</div>
       </div> <!-- /container-fluid -->
     </nav>
 </header>
@@ -132,7 +138,8 @@
 
 
 
-<div class="quarto-about-jolla">
+
+<div class="quarto-about-jolla content">
  <div id="about-block">
 </div>  
 </div>
@@ -218,10 +225,27 @@
     // clear code selection
     e.clearSelection();
   });
-  function tippyHover(el, contentFn) {
+    var localhostRegex = new RegExp(/^(?:http|https):\/\/localhost\:?[0-9]*\//);
+    var mailtoRegex = new RegExp(/^mailto:/);
+      var filterRegex = new RegExp('/' + window.location.host + '/');
+    var isInternal = (href) => {
+        return filterRegex.test(href) || localhostRegex.test(href) || mailtoRegex.test(href);
+    }
+    // Inspect non-navigation links and adorn them if external
+ 	var links = window.document.querySelectorAll('a[href]:not(.nav-link):not(.navbar-brand):not(.toc-action):not(.sidebar-link):not(.sidebar-item-toggle):not(.pagination-link):not(.no-external):not([aria-hidden]):not(.dropdown-item):not(.quarto-navigation-tool)');
+    for (var i=0; i<links.length; i++) {
+      const link = links[i];
+      if (!isInternal(link.href)) {
+        // undo the damage that might have been done by quarto-nav.js in the case of
+        // links that we want to consider external
+        if (link.dataset.originalHref !== undefined) {
+          link.href = link.dataset.originalHref;
+        }
+      }
+    }
+  function tippyHover(el, contentFn, onTriggerFn, onUntriggerFn) {
     const config = {
       allowHTML: true,
-      content: contentFn,
       maxWidth: 500,
       delay: 100,
       arrow: false,
@@ -231,8 +255,17 @@
       interactive: true,
       interactiveBorder: 10,
       theme: 'quarto',
-      placement: 'bottom-start'
+      placement: 'bottom-start',
     };
+    if (contentFn) {
+      config.content = contentFn;
+    }
+    if (onTriggerFn) {
+      config.onTrigger = onTriggerFn;
+    }
+    if (onUntriggerFn) {
+      config.onUntrigger = onUntriggerFn;
+    }
     window.tippy(el, config); 
   }
   const noterefs = window.document.querySelectorAll('a[role="doc-noteref"]');
@@ -244,7 +277,130 @@
       try { href = new URL(href).hash; } catch {}
       const id = href.replace(/^#\/?/, "");
       const note = window.document.getElementById(id);
-      return note.innerHTML;
+      if (note) {
+        return note.innerHTML;
+      } else {
+        return "";
+      }
+    });
+  }
+  const xrefs = window.document.querySelectorAll('a.quarto-xref');
+  const processXRef = (id, note) => {
+    // Strip column container classes
+    const stripColumnClz = (el) => {
+      el.classList.remove("page-full", "page-columns");
+      if (el.children) {
+        for (const child of el.children) {
+          stripColumnClz(child);
+        }
+      }
+    }
+    stripColumnClz(note)
+    if (id === null || id.startsWith('sec-')) {
+      // Special case sections, only their first couple elements
+      const container = document.createElement("div");
+      if (note.children && note.children.length > 2) {
+        container.appendChild(note.children[0].cloneNode(true));
+        for (let i = 1; i < note.children.length; i++) {
+          const child = note.children[i];
+          if (child.tagName === "P" && child.innerText === "") {
+            continue;
+          } else {
+            container.appendChild(child.cloneNode(true));
+            break;
+          }
+        }
+        if (window.Quarto?.typesetMath) {
+          window.Quarto.typesetMath(container);
+        }
+        return container.innerHTML
+      } else {
+        if (window.Quarto?.typesetMath) {
+          window.Quarto.typesetMath(note);
+        }
+        return note.innerHTML;
+      }
+    } else {
+      // Remove any anchor links if they are present
+      const anchorLink = note.querySelector('a.anchorjs-link');
+      if (anchorLink) {
+        anchorLink.remove();
+      }
+      if (window.Quarto?.typesetMath) {
+        window.Quarto.typesetMath(note);
+      }
+      // TODO in 1.5, we should make sure this works without a callout special case
+      if (note.classList.contains("callout")) {
+        return note.outerHTML;
+      } else {
+        return note.innerHTML;
+      }
+    }
+  }
+  for (var i=0; i<xrefs.length; i++) {
+    const xref = xrefs[i];
+    tippyHover(xref, undefined, function(instance) {
+      instance.disable();
+      let url = xref.getAttribute('href');
+      let hash = undefined; 
+      if (url.startsWith('#')) {
+        hash = url;
+      } else {
+        try { hash = new URL(url).hash; } catch {}
+      }
+      if (hash) {
+        const id = hash.replace(/^#\/?/, "");
+        const note = window.document.getElementById(id);
+        if (note !== null) {
+          try {
+            const html = processXRef(id, note.cloneNode(true));
+            instance.setContent(html);
+          } finally {
+            instance.enable();
+            instance.show();
+          }
+        } else {
+          // See if we can fetch this
+          fetch(url.split('#')[0])
+          .then(res => res.text())
+          .then(html => {
+            const parser = new DOMParser();
+            const htmlDoc = parser.parseFromString(html, "text/html");
+            const note = htmlDoc.getElementById(id);
+            if (note !== null) {
+              const html = processXRef(id, note);
+              instance.setContent(html);
+            } 
+          }).finally(() => {
+            instance.enable();
+            instance.show();
+          });
+        }
+      } else {
+        // See if we can fetch a full url (with no hash to target)
+        // This is a special case and we should probably do some content thinning / targeting
+        fetch(url)
+        .then(res => res.text())
+        .then(html => {
+          const parser = new DOMParser();
+          const htmlDoc = parser.parseFromString(html, "text/html");
+          const note = htmlDoc.querySelector('main.content');
+          if (note !== null) {
+            // This should only happen for chapter cross references
+            // (since there is no id in the URL)
+            // remove the first header
+            if (note.children.length > 0 && note.children[0].tagName === "HEADER") {
+              note.children[0].remove();
+            }
+            const html = processXRef(null, note);
+            instance.setContent(html);
+          } 
+        }).finally(() => {
+          instance.enable();
+          instance.show();
+        });
+      }
+    }, function(instance) {
     });
   }
       let selectedAnnoteEl;
@@ -288,6 +444,7 @@
             }
             div.style.top = top - 2 + "px";
             div.style.height = height + 4 + "px";
+            div.style.left = 0;
             let gutterDiv = window.document.getElementById("code-annotation-line-highlight-gutter");
             if (gutterDiv === null) {
               gutterDiv = window.document.createElement("div");
@@ -313,6 +470,32 @@
         });
         selectedAnnoteEl = undefined;
       };
+        // Handle positioning of the toggle
+    window.addEventListener(
+      "resize",
+      throttle(() => {
+        elRect = undefined;
+        if (selectedAnnoteEl) {
+          selectCodeLines(selectedAnnoteEl);
+        }
+      }, 10)
+    );
+    function throttle(fn, ms) {
+    let throttle = false;
+    let timer;
+      return (...args) => {
+        if(!throttle) { // first call gets through
+            fn.apply(this, args);
+            throttle = true;
+        } else { // all the others get throttled
+            if(timer) clearTimeout(timer); // cancel #2
+            timer = setTimeout(() => {
+              fn.apply(this, args);
+              timer = throttle = false;
+            }, ms);
+        }
+      };
+    }
       // Attach click handler to the DT
       const annoteDls = window.document.querySelectorAll('dt[data-target-cell]');
       for (const annoteDlNode of annoteDls) {
@@ -376,4 +559,5 @@
 
 
 
+
 </body></html>
\ No newline at end of file
diff --git a/docs/blog/AP-MS-to-Study-FOSL-Related-Proteins-Interactome/index.html b/docs/blog/AP-MS-to-Study-FOSL-Related-Proteins-Interactome/index.html
index 1cae0d7..7acd285 100644
--- a/docs/blog/AP-MS-to-Study-FOSL-Related-Proteins-Interactome/index.html
+++ b/docs/blog/AP-MS-to-Study-FOSL-Related-Proteins-Interactome/index.html
@@ -2,7 +2,7 @@
 <html xmlns="http://www.w3.org/1999/xhtml" lang="en" xml:lang="en"><head>
 
 <meta charset="utf-8">
-<meta name="generator" content="quarto-1.3.450">
+<meta name="generator" content="quarto-1.4.553">
 
 <meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
 
@@ -46,7 +46,12 @@
   "collapse-after": 3,
   "panel-placement": "end",
   "type": "textbox",
-  "limit": 20,
+  "limit": 50,
+  "keyboard-shortcut": [
+    "f",
+    "/",
+    "s"
+  ],
   "language": {
     "search-no-results-text": "No results",
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     "search-more-match-text": "more match in this document",
     "search-more-matches-text": "more matches in this document",
     "search-clear-button-title": "Clear",
+    "search-text-placeholder": "",
     "search-detached-cancel-button-title": "Cancel",
     "search-submit-button-title": "Submit",
     "search-label": "Search"
@@ -68,9 +74,9 @@
 
 <div id="quarto-search-results"></div>
   <header id="quarto-header" class="headroom fixed-top">
-    <nav class="navbar navbar-expand-lg navbar-dark ">
+    <nav class="navbar navbar-expand-lg " data-bs-theme="dark">
       <div class="navbar-container container-fluid">
-      <div class="navbar-brand-container">
+      <div class="navbar-brand-container mx-auto">
     <a href="../../index.html" class="navbar-brand navbar-brand-logo">
     <img src="../../img/logo.png" alt="" class="navbar-logo">
     </a>
@@ -85,42 +91,42 @@
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             <ul class="navbar-nav navbar-nav-scroll me-auto">
   <li class="nav-item">
-    <a class="nav-link" href="../../about/index.html" rel="" target="">
- <span class="menu-text">About</span></a>
+    <a class="nav-link" href="../../about/index.html"> 
+<span class="menu-text">About</span></a>
   </li>  
   <li class="nav-item">
-    <a class="nav-link" href="../../cv/index.html" rel="" target="">
- <span class="menu-text">CV</span></a>
+    <a class="nav-link" href="../../cv/index.html"> 
+<span class="menu-text">CV</span></a>
   </li>  
   <li class="nav-item">
-    <a class="nav-link" href="../../blog/index.html" rel="" target="">
- <span class="menu-text">Blog</span></a>
+    <a class="nav-link" href="../../blog/index.html"> 
+<span class="menu-text">Blog</span></a>
   </li>  
 </ul>
             <ul class="navbar-nav navbar-nav-scroll ms-auto">
   <li class="nav-item compact">
-    <a class="nav-link" href="https://www.linkedin.com/in/santoshdbhosale/" rel="" target=""><i class="bi bi-linkedin" role="img">
+    <a class="nav-link" href="https://www.linkedin.com/in/santoshdbhosale/"> <i class="bi bi-linkedin" role="img">
 </i> 
- <span class="menu-text"></span></a>
+<span class="menu-text"></span></a>
   </li>  
   <li class="nav-item compact">
-    <a class="nav-link" href="https://github.com/santoshdbhosale" rel="" target=""><i class="bi bi-github" role="img">
+    <a class="nav-link" href="https://github.com/santoshdbhosale"> <i class="bi bi-github" role="img">
 </i> 
- <span class="menu-text"></span></a>
+<span class="menu-text"></span></a>
   </li>  
   <li class="nav-item">
-    <a class="nav-link" href="https://scholar.google.com/citations?user=sIxWbx0AAAAJ&amp;hl=en" rel="" target="">
- <span class="menu-text"><iconify-icon inline="" icon="academicons:google-scholar" style="font-size: 1.5em;"></iconify-icon></span></a>
+    <a class="nav-link" href="https://scholar.google.com/citations?user=sIxWbx0AAAAJ&amp;hl=en"> 
+<span class="menu-text"><iconify-icon inline="" icon="academicons:google-scholar" style="font-size: 1.5em;"></iconify-icon></span></a>
   </li>  
   <li class="nav-item compact">
-    <a class="nav-link" href="mailto:santoshdbhosale@gmail.com" rel="" target=""><i class="bi bi-envelope" role="img" aria-label="email">
+    <a class="nav-link" href="mailto:santoshdbhosale@gmail.com"> <i class="bi bi-envelope" role="img" aria-label="email">
 </i> 
- <span class="menu-text"></span></a>
+<span class="menu-text"></span></a>
   </li>  
 </ul>
-            <div class="quarto-navbar-tools">
-</div>
           </div> <!-- /navcollapse -->
+          <div class="quarto-navbar-tools">
+</div>
       </div> <!-- /container-fluid -->
     </nav>
 </header>
@@ -157,8 +163,10 @@ <h1 class="title">AP-MS to Study FOSL Related Proteins Interactome</h1>
   </div>
   
 
+
 </header>
 
+
 <p>Proteins represent the key interacting biomolecules in the complex network within the cell and their interactions are crucial in orchestrating all aspects of life at the molecular level. Most biochemical functions are not carried out by a specific protein in isolation but by the multiple protein in associations refereed as a protein-protein interactions (PPIs).</p>
 <p>Affinity purification-based mass spectrometry (AP-MS) is a technique of choice in discovering PPIs. These experiments are usually carried out by coupling a bait protein to the protein A or immunoglobulin G (IgG) surfaces or an affinity matrix followed by purification of tagged protein from a cell lysate. Additionally, suitable negative control replicates are mandatorily included to define the non-specific background. The composition of PPIs are then delineated by mass spectrometry analysis. These types of studies are useful in understanding the complicated interplay of proteins inside the cells for generating new hypothesis or may be helpful in placing a specific interactor in a pathway to explain observed phenotypes.</p>
 <p><strong><a href="https://pubs.acs.org/doi/10.1021/acsomega.1c03681">We used AP-MS method to study interactome of FOS related proteins (FOSL1 and FOSL2) in human Th17 cells</a>.</strong> The fate of Th17 cells is regulated by various transcription factors such as BATF, IRF4 and STAT3. Furthermore, the members of the activator protein (AP-1) family including ATF, FOS and JUN also modulate the differentiation of Th17 cells. Of these AP-1 members, FOS related proteins regulates variety of processes such as cancer progression, embryonic development and immune cells signaling. In order to understand how FOS related proteins mediates signaling mechanism in Th17 cells, we performed their interactome analysis.</p>
@@ -249,10 +257,27 @@ <h1 class="title">AP-MS to Study FOSL Related Proteins Interactome</h1>
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-  function tippyHover(el, contentFn) {
+    var localhostRegex = new RegExp(/^(?:http|https):\/\/localhost\:?[0-9]*\//);
+    var mailtoRegex = new RegExp(/^mailto:/);
+      var filterRegex = new RegExp('/' + window.location.host + '/');
+    var isInternal = (href) => {
+        return filterRegex.test(href) || localhostRegex.test(href) || mailtoRegex.test(href);
+    }
+    // Inspect non-navigation links and adorn them if external
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+    for (var i=0; i<links.length; i++) {
+      const link = links[i];
+      if (!isInternal(link.href)) {
+        // undo the damage that might have been done by quarto-nav.js in the case of
+        // links that we want to consider external
+        if (link.dataset.originalHref !== undefined) {
+          link.href = link.dataset.originalHref;
+        }
+      }
+    }
+  function tippyHover(el, contentFn, onTriggerFn, onUntriggerFn) {
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-      content: contentFn,
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@@ -262,8 +287,17 @@ <h1 class="title">AP-MS to Study FOSL Related Proteins Interactome</h1>
       interactive: true,
       interactiveBorder: 10,
       theme: 'quarto',
-      placement: 'bottom-start'
+      placement: 'bottom-start',
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+    if (contentFn) {
+      config.content = contentFn;
+    }
+    if (onTriggerFn) {
+      config.onTrigger = onTriggerFn;
+    }
+    if (onUntriggerFn) {
+      config.onUntrigger = onUntriggerFn;
+    }
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@@ -275,7 +309,130 @@ <h1 class="title">AP-MS to Study FOSL Related Proteins Interactome</h1>
       try { href = new URL(href).hash; } catch {}
       const id = href.replace(/^#\/?/, "");
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-      return note.innerHTML;
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+  const processXRef = (id, note) => {
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+        for (let i = 1; i < note.children.length; i++) {
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+          if (child.tagName === "P" && child.innerText === "") {
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+      } else {
+        if (window.Quarto?.typesetMath) {
+          window.Quarto.typesetMath(note);
+        }
+        return note.innerHTML;
+      }
+    } else {
+      // Remove any anchor links if they are present
+      const anchorLink = note.querySelector('a.anchorjs-link');
+      if (anchorLink) {
+        anchorLink.remove();
+      }
+      if (window.Quarto?.typesetMath) {
+        window.Quarto.typesetMath(note);
+      }
+      // TODO in 1.5, we should make sure this works without a callout special case
+      if (note.classList.contains("callout")) {
+        return note.outerHTML;
+      } else {
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+    const xref = xrefs[i];
+    tippyHover(xref, undefined, function(instance) {
+      instance.disable();
+      let url = xref.getAttribute('href');
+      let hash = undefined; 
+      if (url.startsWith('#')) {
+        hash = url;
+      } else {
+        try { hash = new URL(url).hash; } catch {}
+      }
+      if (hash) {
+        const id = hash.replace(/^#\/?/, "");
+        const note = window.document.getElementById(id);
+        if (note !== null) {
+          try {
+            const html = processXRef(id, note.cloneNode(true));
+            instance.setContent(html);
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+          fetch(url.split('#')[0])
+          .then(res => res.text())
+          .then(html => {
+            const parser = new DOMParser();
+            const htmlDoc = parser.parseFromString(html, "text/html");
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+            if (note !== null) {
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+              instance.setContent(html);
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+            instance.enable();
+            instance.show();
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+      } else {
+        // See if we can fetch a full url (with no hash to target)
+        // This is a special case and we should probably do some content thinning / targeting
+        fetch(url)
+        .then(res => res.text())
+        .then(html => {
+          const parser = new DOMParser();
+          const htmlDoc = parser.parseFromString(html, "text/html");
+          const note = htmlDoc.querySelector('main.content');
+          if (note !== null) {
+            // This should only happen for chapter cross references
+            // (since there is no id in the URL)
+            // remove the first header
+            if (note.children.length > 0 && note.children[0].tagName === "HEADER") {
+              note.children[0].remove();
+            }
+            const html = processXRef(null, note);
+            instance.setContent(html);
+          } 
+        }).finally(() => {
+          instance.enable();
+          instance.show();
+        });
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+    }, function(instance) {
     });
   }
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@@ -319,6 +476,7 @@ <h1 class="title">AP-MS to Study FOSL Related Proteins Interactome</h1>
             }
             div.style.top = top - 2 + "px";
             div.style.height = height + 4 + "px";
+            div.style.left = 0;
             let gutterDiv = window.document.getElementById("code-annotation-line-highlight-gutter");
             if (gutterDiv === null) {
               gutterDiv = window.document.createElement("div");
@@ -344,6 +502,32 @@ <h1 class="title">AP-MS to Study FOSL Related Proteins Interactome</h1>
         });
         selectedAnnoteEl = undefined;
       };
+        // Handle positioning of the toggle
+    window.addEventListener(
+      "resize",
+      throttle(() => {
+        elRect = undefined;
+        if (selectedAnnoteEl) {
+          selectCodeLines(selectedAnnoteEl);
+        }
+      }, 10)
+    );
+    function throttle(fn, ms) {
+    let throttle = false;
+    let timer;
+      return (...args) => {
+        if(!throttle) { // first call gets through
+            fn.apply(this, args);
+            throttle = true;
+        } else { // all the others get throttled
+            if(timer) clearTimeout(timer); // cancel #2
+            timer = setTimeout(() => {
+              fn.apply(this, args);
+              timer = throttle = false;
+            }, ms);
+        }
+      };
+    }
       // Attach click handler to the DT
       const annoteDls = window.document.querySelectorAll('dt[data-target-cell]');
       for (const annoteDlNode of annoteDls) {
@@ -407,4 +591,5 @@ <h1 class="title">AP-MS to Study FOSL Related Proteins Interactome</h1>
 
 
 
+
 </body></html>
\ No newline at end of file
diff --git a/docs/blog/Mass-Spectrometry-Based-Serum-Proteomics/index.html b/docs/blog/Mass-Spectrometry-Based-Serum-Proteomics/index.html
index 9eaac6d..f3e5c81 100644
--- a/docs/blog/Mass-Spectrometry-Based-Serum-Proteomics/index.html
+++ b/docs/blog/Mass-Spectrometry-Based-Serum-Proteomics/index.html
@@ -2,7 +2,7 @@
 <html xmlns="http://www.w3.org/1999/xhtml" lang="en" xml:lang="en"><head>
 
 <meta charset="utf-8">
-<meta name="generator" content="quarto-1.3.450">
+<meta name="generator" content="quarto-1.4.553">
 
 <meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
 
@@ -46,7 +46,12 @@
   "collapse-after": 3,
   "panel-placement": "end",
   "type": "textbox",
-  "limit": 20,
+  "limit": 50,
+  "keyboard-shortcut": [
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+    "/",
+    "s"
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     "search-no-results-text": "No results",
     "search-matching-documents-text": "matching documents",
@@ -55,6 +60,7 @@
     "search-more-match-text": "more match in this document",
     "search-more-matches-text": "more matches in this document",
     "search-clear-button-title": "Clear",
+    "search-text-placeholder": "",
     "search-detached-cancel-button-title": "Cancel",
     "search-submit-button-title": "Submit",
     "search-label": "Search"
@@ -68,9 +74,9 @@
 
 <div id="quarto-search-results"></div>
   <header id="quarto-header" class="headroom fixed-top">
-    <nav class="navbar navbar-expand-lg navbar-dark ">
+    <nav class="navbar navbar-expand-lg " data-bs-theme="dark">
       <div class="navbar-container container-fluid">
-      <div class="navbar-brand-container">
+      <div class="navbar-brand-container mx-auto">
     <a href="../../index.html" class="navbar-brand navbar-brand-logo">
     <img src="../../img/logo.png" alt="" class="navbar-logo">
     </a>
@@ -85,42 +91,42 @@
           <div class="collapse navbar-collapse" id="navbarCollapse">
             <ul class="navbar-nav navbar-nav-scroll me-auto">
   <li class="nav-item">
-    <a class="nav-link" href="../../about/index.html" rel="" target="">
- <span class="menu-text">About</span></a>
+    <a class="nav-link" href="../../about/index.html"> 
+<span class="menu-text">About</span></a>
   </li>  
   <li class="nav-item">
-    <a class="nav-link" href="../../cv/index.html" rel="" target="">
- <span class="menu-text">CV</span></a>
+    <a class="nav-link" href="../../cv/index.html"> 
+<span class="menu-text">CV</span></a>
   </li>  
   <li class="nav-item">
-    <a class="nav-link" href="../../blog/index.html" rel="" target="">
- <span class="menu-text">Blog</span></a>
+    <a class="nav-link" href="../../blog/index.html"> 
+<span class="menu-text">Blog</span></a>
   </li>  
 </ul>
             <ul class="navbar-nav navbar-nav-scroll ms-auto">
   <li class="nav-item compact">
-    <a class="nav-link" href="https://www.linkedin.com/in/santoshdbhosale/" rel="" target=""><i class="bi bi-linkedin" role="img">
+    <a class="nav-link" href="https://www.linkedin.com/in/santoshdbhosale/"> <i class="bi bi-linkedin" role="img">
 </i> 
- <span class="menu-text"></span></a>
+<span class="menu-text"></span></a>
   </li>  
   <li class="nav-item compact">
-    <a class="nav-link" href="https://github.com/santoshdbhosale" rel="" target=""><i class="bi bi-github" role="img">
+    <a class="nav-link" href="https://github.com/santoshdbhosale"> <i class="bi bi-github" role="img">
 </i> 
- <span class="menu-text"></span></a>
+<span class="menu-text"></span></a>
   </li>  
   <li class="nav-item">
-    <a class="nav-link" href="https://scholar.google.com/citations?user=sIxWbx0AAAAJ&amp;hl=en" rel="" target="">
- <span class="menu-text"><iconify-icon inline="" icon="academicons:google-scholar" style="font-size: 1.5em;"></iconify-icon></span></a>
+    <a class="nav-link" href="https://scholar.google.com/citations?user=sIxWbx0AAAAJ&amp;hl=en"> 
+<span class="menu-text"><iconify-icon inline="" icon="academicons:google-scholar" style="font-size: 1.5em;"></iconify-icon></span></a>
   </li>  
   <li class="nav-item compact">
-    <a class="nav-link" href="mailto:santoshdbhosale@gmail.com" rel="" target=""><i class="bi bi-envelope" role="img" aria-label="email">
+    <a class="nav-link" href="mailto:santoshdbhosale@gmail.com"> <i class="bi bi-envelope" role="img" aria-label="email">
 </i> 
- <span class="menu-text"></span></a>
+<span class="menu-text"></span></a>
   </li>  
 </ul>
-            <div class="quarto-navbar-tools">
-</div>
           </div> <!-- /navcollapse -->
+          <div class="quarto-navbar-tools">
+</div>
       </div> <!-- /container-fluid -->
     </nav>
 </header>
@@ -157,8 +163,10 @@ <h1 class="title">Mass Spectrometry Based Serum Proteomics</h1>
   </div>
   
 
+
 </header>
 
+
 <p>I really like Methods in Molecular Biology book series. They publish step by step protocols with detailed information on materials and methods to carry out the experiment in a reproducible manner. In particular notes section provides useful tip and troubleshooting guide.</p>
 <p>We published a protocol entitled <strong><a href="https://link.springer.com/protocol/10.1007/978-1-4939-7057-5_31">Mass Spectrometry-Based Serum Proteomics for Biomarker Discovery and Validation</a>.</strong> It presents a workflow detailing sample preparation with and without immunodepletion of high abundant serum/plasma proteins and, LC-MS/MS methodology for discovery and targeted measurements of candidate biomarkers.</p>
 
@@ -244,10 +252,27 @@ <h1 class="title">Mass Spectrometry Based Serum Proteomics</h1>
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     e.clearSelection();
   });
-  function tippyHover(el, contentFn) {
+    var localhostRegex = new RegExp(/^(?:http|https):\/\/localhost\:?[0-9]*\//);
+    var mailtoRegex = new RegExp(/^mailto:/);
+      var filterRegex = new RegExp('/' + window.location.host + '/');
+    var isInternal = (href) => {
+        return filterRegex.test(href) || localhostRegex.test(href) || mailtoRegex.test(href);
+    }
+    // Inspect non-navigation links and adorn them if external
+ 	var links = window.document.querySelectorAll('a[href]:not(.nav-link):not(.navbar-brand):not(.toc-action):not(.sidebar-link):not(.sidebar-item-toggle):not(.pagination-link):not(.no-external):not([aria-hidden]):not(.dropdown-item):not(.quarto-navigation-tool)');
+    for (var i=0; i<links.length; i++) {
+      const link = links[i];
+      if (!isInternal(link.href)) {
+        // undo the damage that might have been done by quarto-nav.js in the case of
+        // links that we want to consider external
+        if (link.dataset.originalHref !== undefined) {
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-      content: contentFn,
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@@ -257,8 +282,17 @@ <h1 class="title">Mass Spectrometry Based Serum Proteomics</h1>
       interactive: true,
       interactiveBorder: 10,
       theme: 'quarto',
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+      config.onTrigger = onTriggerFn;
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+    if (onUntriggerFn) {
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     window.tippy(el, config); 
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@@ -270,7 +304,130 @@ <h1 class="title">Mass Spectrometry Based Serum Proteomics</h1>
       try { href = new URL(href).hash; } catch {}
       const id = href.replace(/^#\/?/, "");
       const note = window.document.getElementById(id);
-      return note.innerHTML;
+      if (note) {
+        return note.innerHTML;
+      } else {
+        return "";
+      }
+    });
+  }
+  const xrefs = window.document.querySelectorAll('a.quarto-xref');
+  const processXRef = (id, note) => {
+    // Strip column container classes
+    const stripColumnClz = (el) => {
+      el.classList.remove("page-full", "page-columns");
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+    stripColumnClz(note)
+    if (id === null || id.startsWith('sec-')) {
+      // Special case sections, only their first couple elements
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+      if (note.children && note.children.length > 2) {
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+        for (let i = 1; i < note.children.length; i++) {
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+          if (child.tagName === "P" && child.innerText === "") {
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+        return container.innerHTML
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+        if (window.Quarto?.typesetMath) {
+          window.Quarto.typesetMath(note);
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+        return note.innerHTML;
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+    } else {
+      // Remove any anchor links if they are present
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+      if (anchorLink) {
+        anchorLink.remove();
+      }
+      if (window.Quarto?.typesetMath) {
+        window.Quarto.typesetMath(note);
+      }
+      // TODO in 1.5, we should make sure this works without a callout special case
+      if (note.classList.contains("callout")) {
+        return note.outerHTML;
+      } else {
+        return note.innerHTML;
+      }
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+    tippyHover(xref, undefined, function(instance) {
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+      let url = xref.getAttribute('href');
+      let hash = undefined; 
+      if (url.startsWith('#')) {
+        hash = url;
+      } else {
+        try { hash = new URL(url).hash; } catch {}
+      }
+      if (hash) {
+        const id = hash.replace(/^#\/?/, "");
+        const note = window.document.getElementById(id);
+        if (note !== null) {
+          try {
+            const html = processXRef(id, note.cloneNode(true));
+            instance.setContent(html);
+          } finally {
+            instance.enable();
+            instance.show();
+          }
+        } else {
+          // See if we can fetch this
+          fetch(url.split('#')[0])
+          .then(res => res.text())
+          .then(html => {
+            const parser = new DOMParser();
+            const htmlDoc = parser.parseFromString(html, "text/html");
+            const note = htmlDoc.getElementById(id);
+            if (note !== null) {
+              const html = processXRef(id, note);
+              instance.setContent(html);
+            } 
+          }).finally(() => {
+            instance.enable();
+            instance.show();
+          });
+        }
+      } else {
+        // See if we can fetch a full url (with no hash to target)
+        // This is a special case and we should probably do some content thinning / targeting
+        fetch(url)
+        .then(res => res.text())
+        .then(html => {
+          const parser = new DOMParser();
+          const htmlDoc = parser.parseFromString(html, "text/html");
+          const note = htmlDoc.querySelector('main.content');
+          if (note !== null) {
+            // This should only happen for chapter cross references
+            // (since there is no id in the URL)
+            // remove the first header
+            if (note.children.length > 0 && note.children[0].tagName === "HEADER") {
+              note.children[0].remove();
+            }
+            const html = processXRef(null, note);
+            instance.setContent(html);
+          } 
+        }).finally(() => {
+          instance.enable();
+          instance.show();
+        });
+      }
+    }, function(instance) {
     });
   }
       let selectedAnnoteEl;
@@ -314,6 +471,7 @@ <h1 class="title">Mass Spectrometry Based Serum Proteomics</h1>
             }
             div.style.top = top - 2 + "px";
             div.style.height = height + 4 + "px";
+            div.style.left = 0;
             let gutterDiv = window.document.getElementById("code-annotation-line-highlight-gutter");
             if (gutterDiv === null) {
               gutterDiv = window.document.createElement("div");
@@ -339,6 +497,32 @@ <h1 class="title">Mass Spectrometry Based Serum Proteomics</h1>
         });
         selectedAnnoteEl = undefined;
       };
+        // Handle positioning of the toggle
+    window.addEventListener(
+      "resize",
+      throttle(() => {
+        elRect = undefined;
+        if (selectedAnnoteEl) {
+          selectCodeLines(selectedAnnoteEl);
+        }
+      }, 10)
+    );
+    function throttle(fn, ms) {
+    let throttle = false;
+    let timer;
+      return (...args) => {
+        if(!throttle) { // first call gets through
+            fn.apply(this, args);
+            throttle = true;
+        } else { // all the others get throttled
+            if(timer) clearTimeout(timer); // cancel #2
+            timer = setTimeout(() => {
+              fn.apply(this, args);
+              timer = throttle = false;
+            }, ms);
+        }
+      };
+    }
       // Attach click handler to the DT
       const annoteDls = window.document.querySelectorAll('dt[data-target-cell]');
       for (const annoteDlNode of annoteDls) {
@@ -402,4 +586,5 @@ <h1 class="title">Mass Spectrometry Based Serum Proteomics</h1>
 
 
 
+
 </body></html>
\ No newline at end of file
diff --git a/docs/blog/Proteomics-data-analysis-&-visualization/index.html b/docs/blog/Proteomics-data-analysis-&-visualization/index.html
index 27a7fce..4592fd2 100644
--- a/docs/blog/Proteomics-data-analysis-&-visualization/index.html
+++ b/docs/blog/Proteomics-data-analysis-&-visualization/index.html
@@ -2,7 +2,7 @@
 <html xmlns="http://www.w3.org/1999/xhtml" lang="en" xml:lang="en"><head>
 
 <meta charset="utf-8">
-<meta name="generator" content="quarto-1.3.450">
+<meta name="generator" content="quarto-1.4.553">
 
 <meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
 
@@ -46,7 +46,12 @@
   "collapse-after": 3,
   "panel-placement": "end",
   "type": "textbox",
-  "limit": 20,
+  "limit": 50,
+  "keyboard-shortcut": [
+    "f",
+    "/",
+    "s"
+  ],
   "language": {
     "search-no-results-text": "No results",
     "search-matching-documents-text": "matching documents",
@@ -55,6 +60,7 @@
     "search-more-match-text": "more match in this document",
     "search-more-matches-text": "more matches in this document",
     "search-clear-button-title": "Clear",
+    "search-text-placeholder": "",
     "search-detached-cancel-button-title": "Cancel",
     "search-submit-button-title": "Submit",
     "search-label": "Search"
@@ -68,9 +74,9 @@
 
 <div id="quarto-search-results"></div>
   <header id="quarto-header" class="headroom fixed-top">
-    <nav class="navbar navbar-expand-lg navbar-dark ">
+    <nav class="navbar navbar-expand-lg " data-bs-theme="dark">
       <div class="navbar-container container-fluid">
-      <div class="navbar-brand-container">
+      <div class="navbar-brand-container mx-auto">
     <a href="../../index.html" class="navbar-brand navbar-brand-logo">
     <img src="../../img/logo.png" alt="" class="navbar-logo">
     </a>
@@ -85,42 +91,42 @@
           <div class="collapse navbar-collapse" id="navbarCollapse">
             <ul class="navbar-nav navbar-nav-scroll me-auto">
   <li class="nav-item">
-    <a class="nav-link" href="../../about/index.html" rel="" target="">
- <span class="menu-text">About</span></a>
+    <a class="nav-link" href="../../about/index.html"> 
+<span class="menu-text">About</span></a>
   </li>  
   <li class="nav-item">
-    <a class="nav-link" href="../../cv/index.html" rel="" target="">
- <span class="menu-text">CV</span></a>
+    <a class="nav-link" href="../../cv/index.html"> 
+<span class="menu-text">CV</span></a>
   </li>  
   <li class="nav-item">
-    <a class="nav-link" href="../../blog/index.html" rel="" target="">
- <span class="menu-text">Blog</span></a>
+    <a class="nav-link" href="../../blog/index.html"> 
+<span class="menu-text">Blog</span></a>
   </li>  
 </ul>
             <ul class="navbar-nav navbar-nav-scroll ms-auto">
   <li class="nav-item compact">
-    <a class="nav-link" href="https://www.linkedin.com/in/santoshdbhosale/" rel="" target=""><i class="bi bi-linkedin" role="img">
+    <a class="nav-link" href="https://www.linkedin.com/in/santoshdbhosale/"> <i class="bi bi-linkedin" role="img">
 </i> 
- <span class="menu-text"></span></a>
+<span class="menu-text"></span></a>
   </li>  
   <li class="nav-item compact">
-    <a class="nav-link" href="https://github.com/santoshdbhosale" rel="" target=""><i class="bi bi-github" role="img">
+    <a class="nav-link" href="https://github.com/santoshdbhosale"> <i class="bi bi-github" role="img">
 </i> 
- <span class="menu-text"></span></a>
+<span class="menu-text"></span></a>
   </li>  
   <li class="nav-item">
-    <a class="nav-link" href="https://scholar.google.com/citations?user=sIxWbx0AAAAJ&amp;hl=en" rel="" target="">
- <span class="menu-text"><iconify-icon inline="" icon="academicons:google-scholar" style="font-size: 1.5em;"></iconify-icon></span></a>
+    <a class="nav-link" href="https://scholar.google.com/citations?user=sIxWbx0AAAAJ&amp;hl=en"> 
+<span class="menu-text"><iconify-icon inline="" icon="academicons:google-scholar" style="font-size: 1.5em;"></iconify-icon></span></a>
   </li>  
   <li class="nav-item compact">
-    <a class="nav-link" href="mailto:santoshdbhosale@gmail.com" rel="" target=""><i class="bi bi-envelope" role="img" aria-label="email">
+    <a class="nav-link" href="mailto:santoshdbhosale@gmail.com"> <i class="bi bi-envelope" role="img" aria-label="email">
 </i> 
- <span class="menu-text"></span></a>
+<span class="menu-text"></span></a>
   </li>  
 </ul>
-            <div class="quarto-navbar-tools">
-</div>
           </div> <!-- /navcollapse -->
+          <div class="quarto-navbar-tools">
+</div>
       </div> <!-- /container-fluid -->
     </nav>
 </header>
@@ -156,8 +162,10 @@ <h1 class="title">Proteomics data analysis and <em>visualization</em> (no progra
   </div>
   
 
+
 </header>
 
+
 <p>Mass spectrometry based proteomics is the coolest technique to identify and characterize the proteins (including their interaction, alternative splicing, post-transnational modifications and more). Introduction and details about the technology are beyond the scope of this blog post, however, readers are recommended to follow the <a href="https://jessegmeyerlab.github.io/proteomics-tutorial/">comprehensive overview of modern proteomics</a>.</p>
 <p>Typical shotgun proteomics experiment on representative number of samples results in generation of several gigabytes of mass spectrometry data files. The analysis of such data undergoes following steps.</p>
 <ul>
@@ -260,10 +268,27 @@ <h1 class="title">Proteomics data analysis and <em>visualization</em> (no progra
     // clear code selection
     e.clearSelection();
   });
-  function tippyHover(el, contentFn) {
+    var localhostRegex = new RegExp(/^(?:http|https):\/\/localhost\:?[0-9]*\//);
+    var mailtoRegex = new RegExp(/^mailto:/);
+      var filterRegex = new RegExp('/' + window.location.host + '/');
+    var isInternal = (href) => {
+        return filterRegex.test(href) || localhostRegex.test(href) || mailtoRegex.test(href);
+    }
+    // Inspect non-navigation links and adorn them if external
+ 	var links = window.document.querySelectorAll('a[href]:not(.nav-link):not(.navbar-brand):not(.toc-action):not(.sidebar-link):not(.sidebar-item-toggle):not(.pagination-link):not(.no-external):not([aria-hidden]):not(.dropdown-item):not(.quarto-navigation-tool)');
+    for (var i=0; i<links.length; i++) {
+      const link = links[i];
+      if (!isInternal(link.href)) {
+        // undo the damage that might have been done by quarto-nav.js in the case of
+        // links that we want to consider external
+        if (link.dataset.originalHref !== undefined) {
+          link.href = link.dataset.originalHref;
+        }
+      }
+    }
+  function tippyHover(el, contentFn, onTriggerFn, onUntriggerFn) {
     const config = {
       allowHTML: true,
-      content: contentFn,
       maxWidth: 500,
       delay: 100,
       arrow: false,
@@ -273,8 +298,17 @@ <h1 class="title">Proteomics data analysis and <em>visualization</em> (no progra
       interactive: true,
       interactiveBorder: 10,
       theme: 'quarto',
-      placement: 'bottom-start'
+      placement: 'bottom-start',
     };
+    if (contentFn) {
+      config.content = contentFn;
+    }
+    if (onTriggerFn) {
+      config.onTrigger = onTriggerFn;
+    }
+    if (onUntriggerFn) {
+      config.onUntrigger = onUntriggerFn;
+    }
     window.tippy(el, config); 
   }
   const noterefs = window.document.querySelectorAll('a[role="doc-noteref"]');
@@ -286,7 +320,130 @@ <h1 class="title">Proteomics data analysis and <em>visualization</em> (no progra
       try { href = new URL(href).hash; } catch {}
       const id = href.replace(/^#\/?/, "");
       const note = window.document.getElementById(id);
-      return note.innerHTML;
+      if (note) {
+        return note.innerHTML;
+      } else {
+        return "";
+      }
+    });
+  }
+  const xrefs = window.document.querySelectorAll('a.quarto-xref');
+  const processXRef = (id, note) => {
+    // Strip column container classes
+    const stripColumnClz = (el) => {
+      el.classList.remove("page-full", "page-columns");
+      if (el.children) {
+        for (const child of el.children) {
+          stripColumnClz(child);
+        }
+      }
+    }
+    stripColumnClz(note)
+    if (id === null || id.startsWith('sec-')) {
+      // Special case sections, only their first couple elements
+      const container = document.createElement("div");
+      if (note.children && note.children.length > 2) {
+        container.appendChild(note.children[0].cloneNode(true));
+        for (let i = 1; i < note.children.length; i++) {
+          const child = note.children[i];
+          if (child.tagName === "P" && child.innerText === "") {
+            continue;
+          } else {
+            container.appendChild(child.cloneNode(true));
+            break;
+          }
+        }
+        if (window.Quarto?.typesetMath) {
+          window.Quarto.typesetMath(container);
+        }
+        return container.innerHTML
+      } else {
+        if (window.Quarto?.typesetMath) {
+          window.Quarto.typesetMath(note);
+        }
+        return note.innerHTML;
+      }
+    } else {
+      // Remove any anchor links if they are present
+      const anchorLink = note.querySelector('a.anchorjs-link');
+      if (anchorLink) {
+        anchorLink.remove();
+      }
+      if (window.Quarto?.typesetMath) {
+        window.Quarto.typesetMath(note);
+      }
+      // TODO in 1.5, we should make sure this works without a callout special case
+      if (note.classList.contains("callout")) {
+        return note.outerHTML;
+      } else {
+        return note.innerHTML;
+      }
+    }
+  }
+  for (var i=0; i<xrefs.length; i++) {
+    const xref = xrefs[i];
+    tippyHover(xref, undefined, function(instance) {
+      instance.disable();
+      let url = xref.getAttribute('href');
+      let hash = undefined; 
+      if (url.startsWith('#')) {
+        hash = url;
+      } else {
+        try { hash = new URL(url).hash; } catch {}
+      }
+      if (hash) {
+        const id = hash.replace(/^#\/?/, "");
+        const note = window.document.getElementById(id);
+        if (note !== null) {
+          try {
+            const html = processXRef(id, note.cloneNode(true));
+            instance.setContent(html);
+          } finally {
+            instance.enable();
+            instance.show();
+          }
+        } else {
+          // See if we can fetch this
+          fetch(url.split('#')[0])
+          .then(res => res.text())
+          .then(html => {
+            const parser = new DOMParser();
+            const htmlDoc = parser.parseFromString(html, "text/html");
+            const note = htmlDoc.getElementById(id);
+            if (note !== null) {
+              const html = processXRef(id, note);
+              instance.setContent(html);
+            } 
+          }).finally(() => {
+            instance.enable();
+            instance.show();
+          });
+        }
+      } else {
+        // See if we can fetch a full url (with no hash to target)
+        // This is a special case and we should probably do some content thinning / targeting
+        fetch(url)
+        .then(res => res.text())
+        .then(html => {
+          const parser = new DOMParser();
+          const htmlDoc = parser.parseFromString(html, "text/html");
+          const note = htmlDoc.querySelector('main.content');
+          if (note !== null) {
+            // This should only happen for chapter cross references
+            // (since there is no id in the URL)
+            // remove the first header
+            if (note.children.length > 0 && note.children[0].tagName === "HEADER") {
+              note.children[0].remove();
+            }
+            const html = processXRef(null, note);
+            instance.setContent(html);
+          } 
+        }).finally(() => {
+          instance.enable();
+          instance.show();
+        });
+      }
+    }, function(instance) {
     });
   }
       let selectedAnnoteEl;
@@ -330,6 +487,7 @@ <h1 class="title">Proteomics data analysis and <em>visualization</em> (no progra
             }
             div.style.top = top - 2 + "px";
             div.style.height = height + 4 + "px";
+            div.style.left = 0;
             let gutterDiv = window.document.getElementById("code-annotation-line-highlight-gutter");
             if (gutterDiv === null) {
               gutterDiv = window.document.createElement("div");
@@ -355,6 +513,32 @@ <h1 class="title">Proteomics data analysis and <em>visualization</em> (no progra
         });
         selectedAnnoteEl = undefined;
       };
+        // Handle positioning of the toggle
+    window.addEventListener(
+      "resize",
+      throttle(() => {
+        elRect = undefined;
+        if (selectedAnnoteEl) {
+          selectCodeLines(selectedAnnoteEl);
+        }
+      }, 10)
+    );
+    function throttle(fn, ms) {
+    let throttle = false;
+    let timer;
+      return (...args) => {
+        if(!throttle) { // first call gets through
+            fn.apply(this, args);
+            throttle = true;
+        } else { // all the others get throttled
+            if(timer) clearTimeout(timer); // cancel #2
+            timer = setTimeout(() => {
+              fn.apply(this, args);
+              timer = throttle = false;
+            }, ms);
+        }
+      };
+    }
       // Attach click handler to the DT
       const annoteDls = window.document.querySelectorAll('dt[data-target-cell]');
       for (const annoteDlNode of annoteDls) {
@@ -418,4 +602,5 @@ <h1 class="title">Proteomics data analysis and <em>visualization</em> (no progra
 
 
 
+
 </body></html>
\ No newline at end of file
diff --git a/docs/blog/Serum-Proteomics-Atherosclerosis/index.html b/docs/blog/Serum-Proteomics-Atherosclerosis/index.html
index cf74986..5b68450 100644
--- a/docs/blog/Serum-Proteomics-Atherosclerosis/index.html
+++ b/docs/blog/Serum-Proteomics-Atherosclerosis/index.html
@@ -2,7 +2,7 @@
 <html xmlns="http://www.w3.org/1999/xhtml" lang="en" xml:lang="en"><head>
 
 <meta charset="utf-8">
-<meta name="generator" content="quarto-1.3.450">
+<meta name="generator" content="quarto-1.4.553">
 
 <meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
 
@@ -46,7 +46,12 @@
   "collapse-after": 3,
   "panel-placement": "end",
   "type": "textbox",
-  "limit": 20,
+  "limit": 50,
+  "keyboard-shortcut": [
+    "f",
+    "/",
+    "s"
+  ],
   "language": {
     "search-no-results-text": "No results",
     "search-matching-documents-text": "matching documents",
@@ -55,6 +60,7 @@
     "search-more-match-text": "more match in this document",
     "search-more-matches-text": "more matches in this document",
     "search-clear-button-title": "Clear",
+    "search-text-placeholder": "",
     "search-detached-cancel-button-title": "Cancel",
     "search-submit-button-title": "Submit",
     "search-label": "Search"
@@ -68,9 +74,9 @@
 
 <div id="quarto-search-results"></div>
   <header id="quarto-header" class="headroom fixed-top">
-    <nav class="navbar navbar-expand-lg navbar-dark ">
+    <nav class="navbar navbar-expand-lg " data-bs-theme="dark">
       <div class="navbar-container container-fluid">
-      <div class="navbar-brand-container">
+      <div class="navbar-brand-container mx-auto">
     <a href="../../index.html" class="navbar-brand navbar-brand-logo">
     <img src="../../img/logo.png" alt="" class="navbar-logo">
     </a>
@@ -85,42 +91,42 @@
           <div class="collapse navbar-collapse" id="navbarCollapse">
             <ul class="navbar-nav navbar-nav-scroll me-auto">
   <li class="nav-item">
-    <a class="nav-link" href="../../about/index.html" rel="" target="">
- <span class="menu-text">About</span></a>
+    <a class="nav-link" href="../../about/index.html"> 
+<span class="menu-text">About</span></a>
   </li>  
   <li class="nav-item">
-    <a class="nav-link" href="../../cv/index.html" rel="" target="">
- <span class="menu-text">CV</span></a>
+    <a class="nav-link" href="../../cv/index.html"> 
+<span class="menu-text">CV</span></a>
   </li>  
   <li class="nav-item">
-    <a class="nav-link" href="../../blog/index.html" rel="" target="">
- <span class="menu-text">Blog</span></a>
+    <a class="nav-link" href="../../blog/index.html"> 
+<span class="menu-text">Blog</span></a>
   </li>  
 </ul>
             <ul class="navbar-nav navbar-nav-scroll ms-auto">
   <li class="nav-item compact">
-    <a class="nav-link" href="https://www.linkedin.com/in/santoshdbhosale/" rel="" target=""><i class="bi bi-linkedin" role="img">
+    <a class="nav-link" href="https://www.linkedin.com/in/santoshdbhosale/"> <i class="bi bi-linkedin" role="img">
 </i> 
- <span class="menu-text"></span></a>
+<span class="menu-text"></span></a>
   </li>  
   <li class="nav-item compact">
-    <a class="nav-link" href="https://github.com/santoshdbhosale" rel="" target=""><i class="bi bi-github" role="img">
+    <a class="nav-link" href="https://github.com/santoshdbhosale"> <i class="bi bi-github" role="img">
 </i> 
- <span class="menu-text"></span></a>
+<span class="menu-text"></span></a>
   </li>  
   <li class="nav-item">
-    <a class="nav-link" href="https://scholar.google.com/citations?user=sIxWbx0AAAAJ&amp;hl=en" rel="" target="">
- <span class="menu-text"><iconify-icon inline="" icon="academicons:google-scholar" style="font-size: 1.5em;"></iconify-icon></span></a>
+    <a class="nav-link" href="https://scholar.google.com/citations?user=sIxWbx0AAAAJ&amp;hl=en"> 
+<span class="menu-text"><iconify-icon inline="" icon="academicons:google-scholar" style="font-size: 1.5em;"></iconify-icon></span></a>
   </li>  
   <li class="nav-item compact">
-    <a class="nav-link" href="mailto:santoshdbhosale@gmail.com" rel="" target=""><i class="bi bi-envelope" role="img" aria-label="email">
+    <a class="nav-link" href="mailto:santoshdbhosale@gmail.com"> <i class="bi bi-envelope" role="img" aria-label="email">
 </i> 
- <span class="menu-text"></span></a>
+<span class="menu-text"></span></a>
   </li>  
 </ul>
-            <div class="quarto-navbar-tools">
-</div>
           </div> <!-- /navcollapse -->
+          <div class="quarto-navbar-tools">
+</div>
       </div> <!-- /container-fluid -->
     </nav>
 </header>
@@ -157,8 +163,10 @@ <h1 class="title">Serum Proteomics Atherosclerosis</h1>
   </div>
   
 
+
 </header>
 
+
 <p>Atherosclerotic cardiovascular diseases are the major causes of mortality and morbidity in developed world. Thickening of the carotid arterial wall (plaque formation) are indicative of active atherosclerotic process. Myocardial infarction and stroke are the clinical events associated with an acute rupture of a critically located atherosclerotic plaque. Currently, ultrasonic assessment of carotid artery intima media thickness is used as a pre-clinical marker of the disease process. Nevertheless, atherosclerotic process may remain asymptomatic for several decades and whether thickening of intima-media layer of carotid artery and carotid plaque represents two different phenotypes or single traits of disease process is still unclear.</p>
 <p>To gain insights into the pathophysiology of pre-clinical atherosclerosis and identify novel biomarkers, we conducted the <strong><a href="https://www.nature.com/articles/s41598-018-27265-9#Sec1">serum proteomics measurements</a> on the unique sample set of participants recruited in <a href="https://youngfinnsstudy.utu.fi/studydesign.html">The Cardiovascular Risk in Young Finns Study</a>.</strong> We performed label free quantitative MS analysis of serum samples obtained from the subjects in whom early signs of plaques were discerned together with matched controls. The serum samples were immunodepleted to remove high abundant proteins prior to LC-MS/MS analysis.</p>
 <p>The profiling results indicated differential abundances in a set of proteins. Furthermore, selected reaction monitoring mass spectrometry analysis were performed on undepleted serum samples to verify the observed differences. Finally, machine learning analysis identified a panel of three proteins <strong>P23142-4 (Fibulin 1 proteoform C), P02649 (Apolipoprotein E) and P55290 (Cadherin-13)</strong> which segregated the cases from controls with best discrimination (an area under receiver-operating characteristic curve (AUROC) value of 0.79.).</p>
@@ -246,10 +254,27 @@ <h1 class="title">Serum Proteomics Atherosclerosis</h1>
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@@ -341,6 +499,32 @@ <h1 class="title">Serum Proteomics Atherosclerosis</h1>
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@@ -404,4 +588,5 @@ <h1 class="title">Serum Proteomics Atherosclerosis</h1>
 
 
 
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-    <a class="nav-link" href="../../about/index.html" rel="" target="">
- <span class="menu-text">About</span></a>
+    <a class="nav-link" href="../../about/index.html"> 
+<span class="menu-text">About</span></a>
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-    <a class="nav-link" href="../../cv/index.html" rel="" target="">
- <span class="menu-text">CV</span></a>
+    <a class="nav-link" href="../../cv/index.html"> 
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-    <a class="nav-link" href="../../blog/index.html" rel="" target="">
- <span class="menu-text">Blog</span></a>
+    <a class="nav-link" href="../../blog/index.html"> 
+<span class="menu-text">Blog</span></a>
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-    <a class="nav-link" href="https://www.linkedin.com/in/santoshdbhosale/" rel="" target=""><i class="bi bi-linkedin" role="img">
+    <a class="nav-link" href="https://www.linkedin.com/in/santoshdbhosale/"> <i class="bi bi-linkedin" role="img">
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- <span class="menu-text"></span></a>
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+    <a class="nav-link" href="https://github.com/santoshdbhosale"> <i class="bi bi-github" role="img">
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+<span class="menu-text"></span></a>
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+    <a class="nav-link" href="https://scholar.google.com/citations?user=sIxWbx0AAAAJ&amp;hl=en"> 
+<span class="menu-text"><iconify-icon inline="" icon="academicons:google-scholar" style="font-size: 1.5em;"></iconify-icon></span></a>
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-    <a class="nav-link" href="mailto:santoshdbhosale@gmail.com" rel="" target=""><i class="bi bi-envelope" role="img" aria-label="email">
+    <a class="nav-link" href="mailto:santoshdbhosale@gmail.com"> <i class="bi bi-envelope" role="img" aria-label="email">
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- <span class="menu-text"></span></a>
+<span class="menu-text"></span></a>
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-            <div class="quarto-navbar-tools">
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+          <div class="quarto-navbar-tools">
+</div>
       </div> <!-- /container-fluid -->
     </nav>
 </header>
@@ -157,8 +163,10 @@ <h1 class="title">Serum Proteomics Pre diabetic</h1>
   </div>
   
 
+
 </header>
 
+
 <p>Type-1 diabetes (T1D) is an autoimmune disease that is characterized by the destruction of the insulin producing β cells in the Islets of Langerhans of the pancreas. Currently the measurement of autoantibodies (Aabs) like islet-cell autoantibodies, protein tyrosine phosphatase, glutamic acid decarboxylase, insulin and zinc transporter Slc30A8 protein indicates the manifestation of β cells autoimmunity and increased disease risk. However, the destruction of β cells usually starts early in life and symptoms appears when 90% of the cells are destroyed. The time period of appearance of first Aabs to the onset of the clinical disease can vary from 1 month to over 10 years, moreover, not all Aab positive subjects develop T1D. Thus additional indicators of early disease process and progression are needed. To identify disease associated changes, a careful selection of study group is essential such as <strong>The Finnish Type-1 Diabetes Prediction and Prevention project <a href="https://dipp.fi/?page_id=5239&amp;lang=en">DIPP</a></strong> has initiated in 1994. The DIPP cohort has collected blood serum samples at 3 to 6 months intervals from children with a genetically conferred T1D risk and tested for T1D associated autoantibodies. <strong>These longitudinal series of samples cover all the stages of disease progression from birth to clinical T1D and matching samples from carefully matched healthy children.</strong></p>
 <p>We utilized such unique samples from the DIPP cohort to identify early serum protein biomarkers associated with T1D using quantitative mass spectrometry based approach. The study involved LC-MS/MS analysis with both iTRAQ and label-free quantification strategy on the immunodepleted serum.</p>
 <p>Previous serum proteomics biomarker studies of T1D have typically compared disease end points with control groups, i.e.&nbsp;the differences between patients with T1D and healthy controls. In contrast to the published reports, to our knowledge we have shown for the <strong><a href="https://diabetes.diabetesjournals.org/content/64/6/2265">first time serum proteomics profile of pre-diabetic children</a></strong>, mapping the changes from early infancy, seroconversion and diagnosis. The main finding included lower and higher levels of APOC4 and AFAM in cases compared to controls respectively and, the combination of this two proteins classified T1D developing children from controls with 91% success rate with an area under the curve value of 0.85. Notably the levels of APOC4 were found to be lower even before seroconversion.</p>
@@ -245,10 +253,27 @@ <h1 class="title">Serum Proteomics Pre diabetic</h1>
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@@ -258,8 +283,17 @@ <h1 class="title">Serum Proteomics Pre diabetic</h1>
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@@ -340,6 +498,32 @@ <h1 class="title">Serum Proteomics Pre diabetic</h1>
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+              timer = throttle = false;
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       const annoteDls = window.document.querySelectorAll('dt[data-target-cell]');
       for (const annoteDlNode of annoteDls) {
@@ -403,4 +587,5 @@ <h1 class="title">Serum Proteomics Pre diabetic</h1>
 
 
 
+
 </body></html>
\ No newline at end of file
diff --git a/docs/blog/index.html b/docs/blog/index.html
index 22c5acb..cbca742 100644
--- a/docs/blog/index.html
+++ b/docs/blog/index.html
@@ -2,14 +2,14 @@
 <html xmlns="http://www.w3.org/1999/xhtml" lang="en" xml:lang="en"><head>
 
 <meta charset="utf-8">
-<meta name="generator" content="quarto-1.3.450">
+<meta name="generator" content="quarto-1.4.553">
 
 <meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
 
 <meta name="author" content="">
 <meta name="description" content="Welcome to my blog, Here, you will find a collection of posts for some of the previously published articles">
 
-<title>Santosh D. Bhosale – index</title>
+<title>Santosh D. Bhosale</title>
 <style>
 code{white-space: pre-wrap;}
 span.smallcaps{font-variant: small-caps;}
@@ -49,7 +49,12 @@
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   "panel-placement": "end",
   "type": "textbox",
-  "limit": 20,
+  "limit": 50,
+  "keyboard-shortcut": [
+    "f",
+    "/",
+    "s"
+  ],
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     "search-no-results-text": "No results",
     "search-matching-documents-text": "matching documents",
@@ -58,6 +63,7 @@
     "search-more-match-text": "more match in this document",
     "search-more-matches-text": "more matches in this document",
     "search-clear-button-title": "Clear",
+    "search-text-placeholder": "",
     "search-detached-cancel-button-title": "Cancel",
     "search-submit-button-title": "Submit",
     "search-label": "Search"
@@ -96,15 +102,42 @@
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   <script src="https://cdn.jsdelivr.net/npm/mathjax@3/es5/tex-chtml-full.js" type="text/javascript"></script>
 
+<script type="text/javascript">
+const typesetMath = (el) => {
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+    var macros = [];
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+window.Quarto = {
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+
 </head>
 
 <body class="nav-fixed">
 
 <div id="quarto-search-results"></div>
   <header id="quarto-header" class="headroom fixed-top">
-    <nav class="navbar navbar-expand-lg navbar-dark ">
+    <nav class="navbar navbar-expand-lg " data-bs-theme="dark">
       <div class="navbar-container container-fluid">
-      <div class="navbar-brand-container">
+      <div class="navbar-brand-container mx-auto">
     <a href="../index.html" class="navbar-brand navbar-brand-logo">
     <img src="../img/logo.png" alt="" class="navbar-logo">
     </a>
@@ -119,42 +152,42 @@
           <div class="collapse navbar-collapse" id="navbarCollapse">
             <ul class="navbar-nav navbar-nav-scroll me-auto">
   <li class="nav-item">
-    <a class="nav-link" href="../about/index.html" rel="" target="">
- <span class="menu-text">About</span></a>
+    <a class="nav-link" href="../about/index.html"> 
+<span class="menu-text">About</span></a>
   </li>  
   <li class="nav-item">
-    <a class="nav-link" href="../cv/index.html" rel="" target="">
- <span class="menu-text">CV</span></a>
+    <a class="nav-link" href="../cv/index.html"> 
+<span class="menu-text">CV</span></a>
   </li>  
   <li class="nav-item">
-    <a class="nav-link active" href="../blog/index.html" rel="" target="" aria-current="page">
- <span class="menu-text">Blog</span></a>
+    <a class="nav-link active" href="../blog/index.html" aria-current="page"> 
+<span class="menu-text">Blog</span></a>
   </li>  
 </ul>
             <ul class="navbar-nav navbar-nav-scroll ms-auto">
   <li class="nav-item compact">
-    <a class="nav-link" href="https://www.linkedin.com/in/santoshdbhosale/" rel="" target=""><i class="bi bi-linkedin" role="img">
+    <a class="nav-link" href="https://www.linkedin.com/in/santoshdbhosale/"> <i class="bi bi-linkedin" role="img">
 </i> 
- <span class="menu-text"></span></a>
+<span class="menu-text"></span></a>
   </li>  
   <li class="nav-item compact">
-    <a class="nav-link" href="https://github.com/santoshdbhosale" rel="" target=""><i class="bi bi-github" role="img">
+    <a class="nav-link" href="https://github.com/santoshdbhosale"> <i class="bi bi-github" role="img">
 </i> 
- <span class="menu-text"></span></a>
+<span class="menu-text"></span></a>
   </li>  
   <li class="nav-item">
-    <a class="nav-link" href="https://scholar.google.com/citations?user=sIxWbx0AAAAJ&amp;hl=en" rel="" target="">
- <span class="menu-text"><iconify-icon inline="" icon="academicons:google-scholar" style="font-size: 1.5em;"></iconify-icon></span></a>
+    <a class="nav-link" href="https://scholar.google.com/citations?user=sIxWbx0AAAAJ&amp;hl=en"> 
+<span class="menu-text"><iconify-icon inline="" icon="academicons:google-scholar" style="font-size: 1.5em;"></iconify-icon></span></a>
   </li>  
   <li class="nav-item compact">
-    <a class="nav-link" href="mailto:santoshdbhosale@gmail.com" rel="" target=""><i class="bi bi-envelope" role="img" aria-label="email">
+    <a class="nav-link" href="mailto:santoshdbhosale@gmail.com"> <i class="bi bi-envelope" role="img" aria-label="email">
 </i> 
- <span class="menu-text"></span></a>
+<span class="menu-text"></span></a>
   </li>  
 </ul>
-            <div class="quarto-navbar-tools">
-</div>
           </div> <!-- /navcollapse -->
+          <div class="quarto-navbar-tools">
+</div>
       </div> <!-- /container-fluid -->
     </nav>
 </header>
@@ -169,6 +202,7 @@ <h5 class="quarto-listing-category-title">Categories</h5><div class="quarto-list
 
 
 
+
 <p>Welcome to my blog, here, you will find a collection of posts for some of the previously published articles!</p>
 <p>The snapshot of my research work is visualized in the following WordCloud using <a href="https://shiny.rcg.sfu.ca/u/rdmorin/scholar_googler3/">Scholar Googler</a> shiny app. This app extracts information from research publications by using individual’s Google Scholar ID.</p>
 <p><img src="..\img/wordcloud.png" class="img-fluid" width="500"></p>
@@ -178,19 +212,19 @@ <h5 class="quarto-listing-category-title">Categories</h5><div class="quarto-list
 
 <div class="quarto-listing quarto-listing-container-default" id="listing-listing">
 <div class="list quarto-listing-default">
-<div class="quarto-post image-right" data-index="0" data-categories="publications,T cells" data-listing-date-sort="1631775600000" data-listing-file-modified-sort="1696626288242" data-listing-date-modified-sort="NaN" data-listing-reading-time-sort="2">
+<div class="quarto-post image-right" data-index="0" data-categories="publications,T cells" data-listing-date-sort="1631775600000" data-listing-file-modified-sort="1696626288242" data-listing-date-modified-sort="NaN" data-listing-reading-time-sort="2" data-listing-word-count-sort="365">
 <div class="thumbnail">
-<p><a href="../blog/AP-MS-to-Study-FOSL-Related-Proteins-Interactome/index.html"> <img src="../blog/AP-MS-to-Study-FOSL-Related-Proteins-Interactome/fig/FOSL-interactors.png" class="thumbnail-image"> </a></p>
+<p><a href="../blog/AP-MS-to-Study-FOSL-Related-Proteins-Interactome/index.html" class="no-external"></a></p><a href="../blog/AP-MS-to-Study-FOSL-Related-Proteins-Interactome/index.html" class="no-external">
+<p><img src="../blog/AP-MS-to-Study-FOSL-Related-Proteins-Interactome/fig/FOSL-interactors.png" class="thumbnail-image"></p>
+</a><p><a href="../blog/AP-MS-to-Study-FOSL-Related-Proteins-Interactome/index.html" class="no-external"></a></p>
 </div>
 <div class="body">
-<a href="../blog/AP-MS-to-Study-FOSL-Related-Proteins-Interactome/index.html">
 <h3 class="no-anchor listing-title">
-AP-MS to Study FOSL Related Proteins Interactome
+<a href="../blog/AP-MS-to-Study-FOSL-Related-Proteins-Interactome/index.html" class="no-external">AP-MS to Study FOSL Related Proteins Interactome</a>
 </h3>
 <div class="listing-subtitle">
-
+<a href="../blog/AP-MS-to-Study-FOSL-Related-Proteins-Interactome/index.html" class="no-external"></a>
 </div>
-</a>
 <div class="listing-categories">
 <div class="listing-category" onclick="window.quartoListingCategory('publications'); return false;">
 publications
@@ -199,33 +233,31 @@ <h3 class="no-anchor listing-title">
 T cells
 </div>
 </div>
-<a href="../blog/AP-MS-to-Study-FOSL-Related-Proteins-Interactome/index.html">
 <div class="listing-description">
-Proteins represent the key interacting biomolecules in the complex network within the cell and their interactions are crucial in orchestrating all aspects of life at the…
+<a href="../blog/AP-MS-to-Study-FOSL-Related-Proteins-Interactome/index.html" class="no-external">Proteins represent the key interacting biomolecules in the complex network within the cell and their interactions are crucial in orchestrating all aspects of life at the…</a>
 </div>
-</a>
 </div>
 <div class="metadata">
-<a href="../blog/AP-MS-to-Study-FOSL-Related-Proteins-Interactome/index.html">
+<a href="../blog/AP-MS-to-Study-FOSL-Related-Proteins-Interactome/index.html" class="no-external">
 <div class="listing-date">
 September 16, 2021
 </div>
 </a>
 </div>
 </div>
-<div class="quarto-post image-right" data-index="1" data-categories="publications,book chapter" data-listing-date-sort="1605686400000" data-listing-file-modified-sort="1696626288242" data-listing-date-modified-sort="NaN" data-listing-reading-time-sort="1">
+<div class="quarto-post image-right" data-index="1" data-categories="publications,book chapter" data-listing-date-sort="1605686400000" data-listing-file-modified-sort="1696626288242" data-listing-date-modified-sort="NaN" data-listing-reading-time-sort="1" data-listing-word-count-sort="82">
 <div class="thumbnail">
-<p><a href="../blog/Mass-Spectrometry-Based-Serum-Proteomics/index.html"> <div class="listing-item-img-placeholder card-img-top" >&nbsp;</div> </a></p>
+<p><a href="../blog/Mass-Spectrometry-Based-Serum-Proteomics/index.html" class="no-external"></a></p><a href="../blog/Mass-Spectrometry-Based-Serum-Proteomics/index.html" class="no-external">
+<div class="listing-item-img-placeholder card-img-top" >&nbsp;</div>
+</a><p><a href="../blog/Mass-Spectrometry-Based-Serum-Proteomics/index.html" class="no-external"></a></p>
 </div>
 <div class="body">
-<a href="../blog/Mass-Spectrometry-Based-Serum-Proteomics/index.html">
 <h3 class="no-anchor listing-title">
-Mass Spectrometry Based Serum Proteomics
+<a href="../blog/Mass-Spectrometry-Based-Serum-Proteomics/index.html" class="no-external">Mass Spectrometry Based Serum Proteomics</a>
 </h3>
 <div class="listing-subtitle">
-
+<a href="../blog/Mass-Spectrometry-Based-Serum-Proteomics/index.html" class="no-external"></a>
 </div>
-</a>
 <div class="listing-categories">
 <div class="listing-category" onclick="window.quartoListingCategory('publications'); return false;">
 publications
@@ -234,33 +266,31 @@ <h3 class="no-anchor listing-title">
 book chapter
 </div>
 </div>
-<a href="../blog/Mass-Spectrometry-Based-Serum-Proteomics/index.html">
 <div class="listing-description">
-I really like Methods in Molecular Biology book series. They publish step by step protocols…
+<a href="../blog/Mass-Spectrometry-Based-Serum-Proteomics/index.html" class="no-external">I really like Methods in Molecular Biology book series. They publish step by step protocols with detailed information on materials and methods to carry out the experiment in…</a>
 </div>
-</a>
 </div>
 <div class="metadata">
-<a href="../blog/Mass-Spectrometry-Based-Serum-Proteomics/index.html">
+<a href="../blog/Mass-Spectrometry-Based-Serum-Proteomics/index.html" class="no-external">
 <div class="listing-date">
 November 18, 2020
 </div>
 </a>
 </div>
 </div>
-<div class="quarto-post image-right" data-index="2" data-categories="publications,serum" data-listing-date-sort="1605081600000" data-listing-file-modified-sort="1696626288242" data-listing-date-modified-sort="NaN" data-listing-reading-time-sort="2">
+<div class="quarto-post image-right" data-index="2" data-categories="publications,serum" data-listing-date-sort="1605081600000" data-listing-file-modified-sort="1696626288242" data-listing-date-modified-sort="NaN" data-listing-reading-time-sort="2" data-listing-word-count-sort="253">
 <div class="thumbnail">
-<p><a href="../blog/Serum-Proteomics-Atherosclerosis/index.html"> <img src="../blog/Serum-Proteomics-Atherosclerosis/fig/roc-plot.png" class="thumbnail-image"> </a></p>
+<p><a href="../blog/Serum-Proteomics-Atherosclerosis/index.html" class="no-external"></a></p><a href="../blog/Serum-Proteomics-Atherosclerosis/index.html" class="no-external">
+<p><img src="../blog/Serum-Proteomics-Atherosclerosis/fig/roc-plot.png" class="thumbnail-image"></p>
+</a><p><a href="../blog/Serum-Proteomics-Atherosclerosis/index.html" class="no-external"></a></p>
 </div>
 <div class="body">
-<a href="../blog/Serum-Proteomics-Atherosclerosis/index.html">
 <h3 class="no-anchor listing-title">
-Serum Proteomics Atherosclerosis
+<a href="../blog/Serum-Proteomics-Atherosclerosis/index.html" class="no-external">Serum Proteomics Atherosclerosis</a>
 </h3>
 <div class="listing-subtitle">
-
+<a href="../blog/Serum-Proteomics-Atherosclerosis/index.html" class="no-external"></a>
 </div>
-</a>
 <div class="listing-categories">
 <div class="listing-category" onclick="window.quartoListingCategory('publications'); return false;">
 publications
@@ -269,33 +299,31 @@ <h3 class="no-anchor listing-title">
 serum
 </div>
 </div>
-<a href="../blog/Serum-Proteomics-Atherosclerosis/index.html">
 <div class="listing-description">
-Atherosclerotic cardiovascular diseases are the major causes of mortality and morbidity in developed world. Thickening of the carotid arterial wall (plaque formation) are…
+<a href="../blog/Serum-Proteomics-Atherosclerosis/index.html" class="no-external">Atherosclerotic cardiovascular diseases are the major causes of mortality and morbidity in developed world. Thickening of the carotid arterial wall (plaque formation) are…</a>
 </div>
-</a>
 </div>
 <div class="metadata">
-<a href="../blog/Serum-Proteomics-Atherosclerosis/index.html">
+<a href="../blog/Serum-Proteomics-Atherosclerosis/index.html" class="no-external">
 <div class="listing-date">
 November 11, 2020
 </div>
 </a>
 </div>
 </div>
-<div class="quarto-post image-right" data-index="3" data-categories="publications,serum" data-listing-date-sort="1603782000000" data-listing-file-modified-sort="1696626288242" data-listing-date-modified-sort="NaN" data-listing-reading-time-sort="2">
+<div class="quarto-post image-right" data-index="3" data-categories="publications,serum" data-listing-date-sort="1603782000000" data-listing-file-modified-sort="1711394366945" data-listing-date-modified-sort="NaN" data-listing-reading-time-sort="2" data-listing-word-count-sort="356">
 <div class="thumbnail">
-<p><a href="../blog/Serum-Proteomics-Pre-diabetic/index.html"> <div class="listing-item-img-placeholder card-img-top" >&nbsp;</div> </a></p>
+<p><a href="../blog/Serum-Proteomics-Pre-diabetic/index.html" class="no-external"></a></p><a href="../blog/Serum-Proteomics-Pre-diabetic/index.html" class="no-external">
+<div class="listing-item-img-placeholder card-img-top" >&nbsp;</div>
+</a><p><a href="../blog/Serum-Proteomics-Pre-diabetic/index.html" class="no-external"></a></p>
 </div>
 <div class="body">
-<a href="../blog/Serum-Proteomics-Pre-diabetic/index.html">
 <h3 class="no-anchor listing-title">
-Serum Proteomics Pre diabetic
+<a href="../blog/Serum-Proteomics-Pre-diabetic/index.html" class="no-external">Serum Proteomics Pre diabetic</a>
 </h3>
 <div class="listing-subtitle">
-
+<a href="../blog/Serum-Proteomics-Pre-diabetic/index.html" class="no-external"></a>
 </div>
-</a>
 <div class="listing-categories">
 <div class="listing-category" onclick="window.quartoListingCategory('publications'); return false;">
 publications
@@ -304,14 +332,12 @@ <h3 class="no-anchor listing-title">
 serum
 </div>
 </div>
-<a href="../blog/Serum-Proteomics-Pre-diabetic/index.html">
 <div class="listing-description">
-Type-1 diabetes (T1D) is an autoimmune disease that is characterized by the destruction of the insulin producing β cells in the Islets of Langerhans of the pancreas.…<strong></strong><strong></strong>
+<a href="../blog/Serum-Proteomics-Pre-diabetic/index.html" class="no-external">Type-1 diabetes (T1D) is an autoimmune disease that is characterized by the destruction of the insulin producing β cells in the Islets of Langerhans of the pancreas.…<strong></strong><strong></strong></a>
 </div>
-</a>
 </div>
 <div class="metadata">
-<a href="../blog/Serum-Proteomics-Pre-diabetic/index.html">
+<a href="../blog/Serum-Proteomics-Pre-diabetic/index.html" class="no-external">
 <div class="listing-date">
 October 27, 2020
 </div>
@@ -402,10 +428,27 @@ <h3 class="no-anchor listing-title">
     // clear code selection
     e.clearSelection();
   });
-  function tippyHover(el, contentFn) {
+    var localhostRegex = new RegExp(/^(?:http|https):\/\/localhost\:?[0-9]*\//);
+    var mailtoRegex = new RegExp(/^mailto:/);
+      var filterRegex = new RegExp('/' + window.location.host + '/');
+    var isInternal = (href) => {
+        return filterRegex.test(href) || localhostRegex.test(href) || mailtoRegex.test(href);
+    }
+    // Inspect non-navigation links and adorn them if external
+ 	var links = window.document.querySelectorAll('a[href]:not(.nav-link):not(.navbar-brand):not(.toc-action):not(.sidebar-link):not(.sidebar-item-toggle):not(.pagination-link):not(.no-external):not([aria-hidden]):not(.dropdown-item):not(.quarto-navigation-tool)');
+    for (var i=0; i<links.length; i++) {
+      const link = links[i];
+      if (!isInternal(link.href)) {
+        // undo the damage that might have been done by quarto-nav.js in the case of
+        // links that we want to consider external
+        if (link.dataset.originalHref !== undefined) {
+          link.href = link.dataset.originalHref;
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+    }
+  function tippyHover(el, contentFn, onTriggerFn, onUntriggerFn) {
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       maxWidth: 500,
       delay: 100,
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@@ -415,8 +458,17 @@ <h3 class="no-anchor listing-title">
       interactive: true,
       interactiveBorder: 10,
       theme: 'quarto',
-      placement: 'bottom-start'
+      placement: 'bottom-start',
     };
+    if (contentFn) {
+      config.content = contentFn;
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+    if (onTriggerFn) {
+      config.onTrigger = onTriggerFn;
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+    if (onUntriggerFn) {
+      config.onUntrigger = onUntriggerFn;
+    }
     window.tippy(el, config); 
   }
   const noterefs = window.document.querySelectorAll('a[role="doc-noteref"]');
@@ -428,7 +480,130 @@ <h3 class="no-anchor listing-title">
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       const id = href.replace(/^#\/?/, "");
       const note = window.document.getElementById(id);
-      return note.innerHTML;
+      if (note) {
+        return note.innerHTML;
+      } else {
+        return "";
+      }
+    });
+  }
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+  const processXRef = (id, note) => {
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+    const stripColumnClz = (el) => {
+      el.classList.remove("page-full", "page-columns");
+      if (el.children) {
+        for (const child of el.children) {
+          stripColumnClz(child);
+        }
+      }
+    }
+    stripColumnClz(note)
+    if (id === null || id.startsWith('sec-')) {
+      // Special case sections, only their first couple elements
+      const container = document.createElement("div");
+      if (note.children && note.children.length > 2) {
+        container.appendChild(note.children[0].cloneNode(true));
+        for (let i = 1; i < note.children.length; i++) {
+          const child = note.children[i];
+          if (child.tagName === "P" && child.innerText === "") {
+            continue;
+          } else {
+            container.appendChild(child.cloneNode(true));
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+        anchorLink.remove();
+      }
+      if (window.Quarto?.typesetMath) {
+        window.Quarto.typesetMath(note);
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+      // TODO in 1.5, we should make sure this works without a callout special case
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+        return note.outerHTML;
+      } else {
+        return note.innerHTML;
+      }
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+  for (var i=0; i<xrefs.length; i++) {
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+    tippyHover(xref, undefined, function(instance) {
+      instance.disable();
+      let url = xref.getAttribute('href');
+      let hash = undefined; 
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+      } else {
+        try { hash = new URL(url).hash; } catch {}
+      }
+      if (hash) {
+        const id = hash.replace(/^#\/?/, "");
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+            instance.setContent(html);
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+            instance.show();
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+          .then(res => res.text())
+          .then(html => {
+            const parser = new DOMParser();
+            const htmlDoc = parser.parseFromString(html, "text/html");
+            const note = htmlDoc.getElementById(id);
+            if (note !== null) {
+              const html = processXRef(id, note);
+              instance.setContent(html);
+            } 
+          }).finally(() => {
+            instance.enable();
+            instance.show();
+          });
+        }
+      } else {
+        // See if we can fetch a full url (with no hash to target)
+        // This is a special case and we should probably do some content thinning / targeting
+        fetch(url)
+        .then(res => res.text())
+        .then(html => {
+          const parser = new DOMParser();
+          const htmlDoc = parser.parseFromString(html, "text/html");
+          const note = htmlDoc.querySelector('main.content');
+          if (note !== null) {
+            // This should only happen for chapter cross references
+            // (since there is no id in the URL)
+            // remove the first header
+            if (note.children.length > 0 && note.children[0].tagName === "HEADER") {
+              note.children[0].remove();
+            }
+            const html = processXRef(null, note);
+            instance.setContent(html);
+          } 
+        }).finally(() => {
+          instance.enable();
+          instance.show();
+        });
+      }
+    }, function(instance) {
     });
   }
       let selectedAnnoteEl;
@@ -472,6 +647,7 @@ <h3 class="no-anchor listing-title">
             }
             div.style.top = top - 2 + "px";
             div.style.height = height + 4 + "px";
+            div.style.left = 0;
             let gutterDiv = window.document.getElementById("code-annotation-line-highlight-gutter");
             if (gutterDiv === null) {
               gutterDiv = window.document.createElement("div");
@@ -497,6 +673,32 @@ <h3 class="no-anchor listing-title">
         });
         selectedAnnoteEl = undefined;
       };
+        // Handle positioning of the toggle
+    window.addEventListener(
+      "resize",
+      throttle(() => {
+        elRect = undefined;
+        if (selectedAnnoteEl) {
+          selectCodeLines(selectedAnnoteEl);
+        }
+      }, 10)
+    );
+    function throttle(fn, ms) {
+    let throttle = false;
+    let timer;
+      return (...args) => {
+        if(!throttle) { // first call gets through
+            fn.apply(this, args);
+            throttle = true;
+        } else { // all the others get throttled
+            if(timer) clearTimeout(timer); // cancel #2
+            timer = setTimeout(() => {
+              fn.apply(this, args);
+              timer = throttle = false;
+            }, ms);
+        }
+      };
+    }
       // Attach click handler to the DT
       const annoteDls = window.document.querySelectorAll('dt[data-target-cell]');
       for (const annoteDlNode of annoteDls) {
@@ -560,4 +762,5 @@ <h3 class="no-anchor listing-title">
 
 
 
+
 </body></html>
\ No newline at end of file
diff --git a/docs/cv/index.html b/docs/cv/index.html
index 81cab34..80e9fd9 100644
--- a/docs/cv/index.html
+++ b/docs/cv/index.html
@@ -2,7 +2,7 @@
 <html xmlns="http://www.w3.org/1999/xhtml" lang="en" xml:lang="en"><head>
 
 <meta charset="utf-8">
-<meta name="generator" content="quarto-1.3.450">
+<meta name="generator" content="quarto-1.4.553">
 
 <meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
 
@@ -45,7 +45,12 @@
   "collapse-after": 3,
   "panel-placement": "end",
   "type": "textbox",
-  "limit": 20,
+  "limit": 50,
+  "keyboard-shortcut": [
+    "f",
+    "/",
+    "s"
+  ],
   "language": {
     "search-no-results-text": "No results",
     "search-matching-documents-text": "matching documents",
@@ -54,6 +59,7 @@
     "search-more-match-text": "more match in this document",
     "search-more-matches-text": "more matches in this document",
     "search-clear-button-title": "Clear",
+    "search-text-placeholder": "",
     "search-detached-cancel-button-title": "Cancel",
     "search-submit-button-title": "Submit",
     "search-label": "Search"
@@ -67,9 +73,9 @@
 
 <div id="quarto-search-results"></div>
   <header id="quarto-header" class="headroom fixed-top">
-    <nav class="navbar navbar-expand-lg navbar-dark ">
+    <nav class="navbar navbar-expand-lg " data-bs-theme="dark">
       <div class="navbar-container container-fluid">
-      <div class="navbar-brand-container">
+      <div class="navbar-brand-container mx-auto">
     <a href="../index.html" class="navbar-brand navbar-brand-logo">
     <img src="../img/logo.png" alt="" class="navbar-logo">
     </a>
@@ -84,42 +90,42 @@
           <div class="collapse navbar-collapse" id="navbarCollapse">
             <ul class="navbar-nav navbar-nav-scroll me-auto">
   <li class="nav-item">
-    <a class="nav-link" href="../about/index.html" rel="" target="">
- <span class="menu-text">About</span></a>
+    <a class="nav-link" href="../about/index.html"> 
+<span class="menu-text">About</span></a>
   </li>  
   <li class="nav-item">
-    <a class="nav-link active" href="../cv/index.html" rel="" target="" aria-current="page">
- <span class="menu-text">CV</span></a>
+    <a class="nav-link active" href="../cv/index.html" aria-current="page"> 
+<span class="menu-text">CV</span></a>
   </li>  
   <li class="nav-item">
-    <a class="nav-link" href="../blog/index.html" rel="" target="">
- <span class="menu-text">Blog</span></a>
+    <a class="nav-link" href="../blog/index.html"> 
+<span class="menu-text">Blog</span></a>
   </li>  
 </ul>
             <ul class="navbar-nav navbar-nav-scroll ms-auto">
   <li class="nav-item compact">
-    <a class="nav-link" href="https://www.linkedin.com/in/santoshdbhosale/" rel="" target=""><i class="bi bi-linkedin" role="img">
+    <a class="nav-link" href="https://www.linkedin.com/in/santoshdbhosale/"> <i class="bi bi-linkedin" role="img">
 </i> 
- <span class="menu-text"></span></a>
+<span class="menu-text"></span></a>
   </li>  
   <li class="nav-item compact">
-    <a class="nav-link" href="https://github.com/santoshdbhosale" rel="" target=""><i class="bi bi-github" role="img">
+    <a class="nav-link" href="https://github.com/santoshdbhosale"> <i class="bi bi-github" role="img">
 </i> 
- <span class="menu-text"></span></a>
+<span class="menu-text"></span></a>
   </li>  
   <li class="nav-item">
-    <a class="nav-link" href="https://scholar.google.com/citations?user=sIxWbx0AAAAJ&amp;hl=en" rel="" target="">
- <span class="menu-text"><iconify-icon inline="" icon="academicons:google-scholar" style="font-size: 1.5em;"></iconify-icon></span></a>
+    <a class="nav-link" href="https://scholar.google.com/citations?user=sIxWbx0AAAAJ&amp;hl=en"> 
+<span class="menu-text"><iconify-icon inline="" icon="academicons:google-scholar" style="font-size: 1.5em;"></iconify-icon></span></a>
   </li>  
   <li class="nav-item compact">
-    <a class="nav-link" href="mailto:santoshdbhosale@gmail.com" rel="" target=""><i class="bi bi-envelope" role="img" aria-label="email">
+    <a class="nav-link" href="mailto:santoshdbhosale@gmail.com"> <i class="bi bi-envelope" role="img" aria-label="email">
 </i> 
- <span class="menu-text"></span></a>
+<span class="menu-text"></span></a>
   </li>  
 </ul>
-            <div class="quarto-navbar-tools">
-</div>
           </div> <!-- /navcollapse -->
+          <div class="quarto-navbar-tools">
+</div>
       </div> <!-- /container-fluid -->
     </nav>
 </header>
@@ -146,8 +152,10 @@ <h1 class="title">Curriculum vitae</h1>
   </div>
   
 
+
 </header>
 
+
 <div class="cell">
 <style type="text/css">
 .embed-container {
@@ -262,10 +270,27 @@ <h1 class="title">Curriculum vitae</h1>
     // clear code selection
     e.clearSelection();
   });
-  function tippyHover(el, contentFn) {
+    var localhostRegex = new RegExp(/^(?:http|https):\/\/localhost\:?[0-9]*\//);
+    var mailtoRegex = new RegExp(/^mailto:/);
+      var filterRegex = new RegExp('/' + window.location.host + '/');
+    var isInternal = (href) => {
+        return filterRegex.test(href) || localhostRegex.test(href) || mailtoRegex.test(href);
+    }
+    // Inspect non-navigation links and adorn them if external
+ 	var links = window.document.querySelectorAll('a[href]:not(.nav-link):not(.navbar-brand):not(.toc-action):not(.sidebar-link):not(.sidebar-item-toggle):not(.pagination-link):not(.no-external):not([aria-hidden]):not(.dropdown-item):not(.quarto-navigation-tool)');
+    for (var i=0; i<links.length; i++) {
+      const link = links[i];
+      if (!isInternal(link.href)) {
+        // undo the damage that might have been done by quarto-nav.js in the case of
+        // links that we want to consider external
+        if (link.dataset.originalHref !== undefined) {
+          link.href = link.dataset.originalHref;
+        }
+      }
+    }
+  function tippyHover(el, contentFn, onTriggerFn, onUntriggerFn) {
     const config = {
       allowHTML: true,
-      content: contentFn,
       maxWidth: 500,
       delay: 100,
       arrow: false,
@@ -275,8 +300,17 @@ <h1 class="title">Curriculum vitae</h1>
       interactive: true,
       interactiveBorder: 10,
       theme: 'quarto',
-      placement: 'bottom-start'
+      placement: 'bottom-start',
     };
+    if (contentFn) {
+      config.content = contentFn;
+    }
+    if (onTriggerFn) {
+      config.onTrigger = onTriggerFn;
+    }
+    if (onUntriggerFn) {
+      config.onUntrigger = onUntriggerFn;
+    }
     window.tippy(el, config); 
   }
   const noterefs = window.document.querySelectorAll('a[role="doc-noteref"]');
@@ -288,7 +322,130 @@ <h1 class="title">Curriculum vitae</h1>
       try { href = new URL(href).hash; } catch {}
       const id = href.replace(/^#\/?/, "");
       const note = window.document.getElementById(id);
-      return note.innerHTML;
+      if (note) {
+        return note.innerHTML;
+      } else {
+        return "";
+      }
+    });
+  }
+  const xrefs = window.document.querySelectorAll('a.quarto-xref');
+  const processXRef = (id, note) => {
+    // Strip column container classes
+    const stripColumnClz = (el) => {
+      el.classList.remove("page-full", "page-columns");
+      if (el.children) {
+        for (const child of el.children) {
+          stripColumnClz(child);
+        }
+      }
+    }
+    stripColumnClz(note)
+    if (id === null || id.startsWith('sec-')) {
+      // Special case sections, only their first couple elements
+      const container = document.createElement("div");
+      if (note.children && note.children.length > 2) {
+        container.appendChild(note.children[0].cloneNode(true));
+        for (let i = 1; i < note.children.length; i++) {
+          const child = note.children[i];
+          if (child.tagName === "P" && child.innerText === "") {
+            continue;
+          } else {
+            container.appendChild(child.cloneNode(true));
+            break;
+          }
+        }
+        if (window.Quarto?.typesetMath) {
+          window.Quarto.typesetMath(container);
+        }
+        return container.innerHTML
+      } else {
+        if (window.Quarto?.typesetMath) {
+          window.Quarto.typesetMath(note);
+        }
+        return note.innerHTML;
+      }
+    } else {
+      // Remove any anchor links if they are present
+      const anchorLink = note.querySelector('a.anchorjs-link');
+      if (anchorLink) {
+        anchorLink.remove();
+      }
+      if (window.Quarto?.typesetMath) {
+        window.Quarto.typesetMath(note);
+      }
+      // TODO in 1.5, we should make sure this works without a callout special case
+      if (note.classList.contains("callout")) {
+        return note.outerHTML;
+      } else {
+        return note.innerHTML;
+      }
+    }
+  }
+  for (var i=0; i<xrefs.length; i++) {
+    const xref = xrefs[i];
+    tippyHover(xref, undefined, function(instance) {
+      instance.disable();
+      let url = xref.getAttribute('href');
+      let hash = undefined; 
+      if (url.startsWith('#')) {
+        hash = url;
+      } else {
+        try { hash = new URL(url).hash; } catch {}
+      }
+      if (hash) {
+        const id = hash.replace(/^#\/?/, "");
+        const note = window.document.getElementById(id);
+        if (note !== null) {
+          try {
+            const html = processXRef(id, note.cloneNode(true));
+            instance.setContent(html);
+          } finally {
+            instance.enable();
+            instance.show();
+          }
+        } else {
+          // See if we can fetch this
+          fetch(url.split('#')[0])
+          .then(res => res.text())
+          .then(html => {
+            const parser = new DOMParser();
+            const htmlDoc = parser.parseFromString(html, "text/html");
+            const note = htmlDoc.getElementById(id);
+            if (note !== null) {
+              const html = processXRef(id, note);
+              instance.setContent(html);
+            } 
+          }).finally(() => {
+            instance.enable();
+            instance.show();
+          });
+        }
+      } else {
+        // See if we can fetch a full url (with no hash to target)
+        // This is a special case and we should probably do some content thinning / targeting
+        fetch(url)
+        .then(res => res.text())
+        .then(html => {
+          const parser = new DOMParser();
+          const htmlDoc = parser.parseFromString(html, "text/html");
+          const note = htmlDoc.querySelector('main.content');
+          if (note !== null) {
+            // This should only happen for chapter cross references
+            // (since there is no id in the URL)
+            // remove the first header
+            if (note.children.length > 0 && note.children[0].tagName === "HEADER") {
+              note.children[0].remove();
+            }
+            const html = processXRef(null, note);
+            instance.setContent(html);
+          } 
+        }).finally(() => {
+          instance.enable();
+          instance.show();
+        });
+      }
+    }, function(instance) {
     });
   }
       let selectedAnnoteEl;
@@ -332,6 +489,7 @@ <h1 class="title">Curriculum vitae</h1>
             }
             div.style.top = top - 2 + "px";
             div.style.height = height + 4 + "px";
+            div.style.left = 0;
             let gutterDiv = window.document.getElementById("code-annotation-line-highlight-gutter");
             if (gutterDiv === null) {
               gutterDiv = window.document.createElement("div");
@@ -357,6 +515,32 @@ <h1 class="title">Curriculum vitae</h1>
         });
         selectedAnnoteEl = undefined;
       };
+        // Handle positioning of the toggle
+    window.addEventListener(
+      "resize",
+      throttle(() => {
+        elRect = undefined;
+        if (selectedAnnoteEl) {
+          selectCodeLines(selectedAnnoteEl);
+        }
+      }, 10)
+    );
+    function throttle(fn, ms) {
+    let throttle = false;
+    let timer;
+      return (...args) => {
+        if(!throttle) { // first call gets through
+            fn.apply(this, args);
+            throttle = true;
+        } else { // all the others get throttled
+            if(timer) clearTimeout(timer); // cancel #2
+            timer = setTimeout(() => {
+              fn.apply(this, args);
+              timer = throttle = false;
+            }, ms);
+        }
+      };
+    }
       // Attach click handler to the DT
       const annoteDls = window.document.querySelectorAll('dt[data-target-cell]');
       for (const annoteDlNode of annoteDls) {
@@ -420,4 +604,5 @@ <h1 class="title">Curriculum vitae</h1>
 
 
 
+
 </body></html>
\ No newline at end of file
diff --git a/docs/index.html b/docs/index.html
index b046705..28f97aa 100644
--- a/docs/index.html
+++ b/docs/index.html
@@ -2,7 +2,7 @@
 <html xmlns="http://www.w3.org/1999/xhtml" lang="en" xml:lang="en"><head>
 
 <meta charset="utf-8">
-<meta name="generator" content="quarto-1.3.450">
+<meta name="generator" content="quarto-1.4.553">
 
 <meta name="viewport" content="width=device-width, initial-scale=1.0, user-scalable=yes">
 
@@ -44,7 +44,12 @@
   "collapse-after": 3,
   "panel-placement": "end",
   "type": "textbox",
-  "limit": 20,
+  "limit": 50,
+  "keyboard-shortcut": [
+    "f",
+    "/",
+    "s"
+  ],
   "language": {
     "search-no-results-text": "No results",
     "search-matching-documents-text": "matching documents",
@@ -53,6 +58,7 @@
     "search-more-match-text": "more match in this document",
     "search-more-matches-text": "more matches in this document",
     "search-clear-button-title": "Clear",
+    "search-text-placeholder": "",
     "search-detached-cancel-button-title": "Cancel",
     "search-submit-button-title": "Submit",
     "search-label": "Search"
@@ -66,9 +72,9 @@
 
 <div id="quarto-search-results"></div>
   <header id="quarto-header" class="headroom fixed-top">
-    <nav class="navbar navbar-expand-lg navbar-dark ">
+    <nav class="navbar navbar-expand-lg " data-bs-theme="dark">
       <div class="navbar-container container-fluid">
-      <div class="navbar-brand-container">
+      <div class="navbar-brand-container mx-auto">
     <a href="./index.html" class="navbar-brand navbar-brand-logo">
     <img src="./img/logo.png" alt="" class="navbar-logo">
     </a>
@@ -83,42 +89,42 @@
           <div class="collapse navbar-collapse" id="navbarCollapse">
             <ul class="navbar-nav navbar-nav-scroll me-auto">
   <li class="nav-item">
-    <a class="nav-link" href="./about/index.html" rel="" target="">
- <span class="menu-text">About</span></a>
+    <a class="nav-link" href="./about/index.html"> 
+<span class="menu-text">About</span></a>
   </li>  
   <li class="nav-item">
-    <a class="nav-link" href="./cv/index.html" rel="" target="">
- <span class="menu-text">CV</span></a>
+    <a class="nav-link" href="./cv/index.html"> 
+<span class="menu-text">CV</span></a>
   </li>  
   <li class="nav-item">
-    <a class="nav-link" href="./blog/index.html" rel="" target="">
- <span class="menu-text">Blog</span></a>
+    <a class="nav-link" href="./blog/index.html"> 
+<span class="menu-text">Blog</span></a>
   </li>  
 </ul>
             <ul class="navbar-nav navbar-nav-scroll ms-auto">
   <li class="nav-item compact">
-    <a class="nav-link" href="https://www.linkedin.com/in/santoshdbhosale/" rel="" target=""><i class="bi bi-linkedin" role="img">
+    <a class="nav-link" href="https://www.linkedin.com/in/santoshdbhosale/"> <i class="bi bi-linkedin" role="img">
 </i> 
- <span class="menu-text"></span></a>
+<span class="menu-text"></span></a>
   </li>  
   <li class="nav-item compact">
-    <a class="nav-link" href="https://github.com/santoshdbhosale" rel="" target=""><i class="bi bi-github" role="img">
+    <a class="nav-link" href="https://github.com/santoshdbhosale"> <i class="bi bi-github" role="img">
 </i> 
- <span class="menu-text"></span></a>
+<span class="menu-text"></span></a>
   </li>  
   <li class="nav-item">
-    <a class="nav-link" href="https://scholar.google.com/citations?user=sIxWbx0AAAAJ&amp;hl=en" rel="" target="">
- <span class="menu-text"><iconify-icon inline="" icon="academicons:google-scholar" style="font-size: 1.5em;"></iconify-icon></span></a>
+    <a class="nav-link" href="https://scholar.google.com/citations?user=sIxWbx0AAAAJ&amp;hl=en"> 
+<span class="menu-text"><iconify-icon inline="" icon="academicons:google-scholar" style="font-size: 1.5em;"></iconify-icon></span></a>
   </li>  
   <li class="nav-item compact">
-    <a class="nav-link" href="mailto:santoshdbhosale@gmail.com" rel="" target=""><i class="bi bi-envelope" role="img" aria-label="email">
+    <a class="nav-link" href="mailto:santoshdbhosale@gmail.com"> <i class="bi bi-envelope" role="img" aria-label="email">
 </i> 
- <span class="menu-text"></span></a>
+<span class="menu-text"></span></a>
   </li>  
 </ul>
-            <div class="quarto-navbar-tools">
-</div>
           </div> <!-- /navcollapse -->
+          <div class="quarto-navbar-tools">
+</div>
       </div> <!-- /container-fluid -->
     </nav>
 </header>
@@ -132,7 +138,8 @@
 
 
 
-<div class="quarto-about-jolla">
+
+<div class="quarto-about-jolla content">
   <img src="img/SDB1.jpg" class="about-image
   round " style="height: 15em; width: 15em;">
  <div id="about-block">
@@ -143,7 +150,7 @@
 <h1>Understanding the Complexity of Proteome!</h1>
 <p>Hi, I’m Santosh D. Bhosale, pharmacist by training and currently working as an associate biomedical scientist at <strong><a href="https://www.cs-pbl.com/">Cedars-Sinai Precision biomarker laboratories</a></strong>, Los Angeles, CA, USA.</p>
 <p>Using the versatility of mass spectrometry-based proteomics, I am exploring the properties of biologically important proteins.</p>
-<p>Precisely, I work on mass spectrometry-based proteomics technologies to address the questions related to biomedical research. These includes not only the qualitative and quantitative measurement of proteins, but also their post-translational modifications and interactions with other proteins. I use computational methods to understand the complexity of proteins.</p>
+<p>Precisely, I work on mass spectrometry-based proteomics technologies to address the questions related to biomedical research. These includes not only the qualitative and quantitative measurement of proteins, but also their post-translational modifications and interactions with other proteins. I use variety of computational methods to understand the complexity of proteins.</p>
 <p><img src="img/Proteomics.png" class="img-fluid"></p>
 
 
@@ -223,10 +230,27 @@ <h1>Understanding the Complexity of Proteome!</h1>
     // clear code selection
     e.clearSelection();
   });
-  function tippyHover(el, contentFn) {
+    var localhostRegex = new RegExp(/^(?:http|https):\/\/localhost\:?[0-9]*\//);
+    var mailtoRegex = new RegExp(/^mailto:/);
+      var filterRegex = new RegExp('/' + window.location.host + '/');
+    var isInternal = (href) => {
+        return filterRegex.test(href) || localhostRegex.test(href) || mailtoRegex.test(href);
+    }
+    // Inspect non-navigation links and adorn them if external
+ 	var links = window.document.querySelectorAll('a[href]:not(.nav-link):not(.navbar-brand):not(.toc-action):not(.sidebar-link):not(.sidebar-item-toggle):not(.pagination-link):not(.no-external):not([aria-hidden]):not(.dropdown-item):not(.quarto-navigation-tool)');
+    for (var i=0; i<links.length; i++) {
+      const link = links[i];
+      if (!isInternal(link.href)) {
+        // undo the damage that might have been done by quarto-nav.js in the case of
+        // links that we want to consider external
+        if (link.dataset.originalHref !== undefined) {
+          link.href = link.dataset.originalHref;
+        }
+      }
+    }
+  function tippyHover(el, contentFn, onTriggerFn, onUntriggerFn) {
     const config = {
       allowHTML: true,
-      content: contentFn,
       maxWidth: 500,
       delay: 100,
       arrow: false,
@@ -236,8 +260,17 @@ <h1>Understanding the Complexity of Proteome!</h1>
       interactive: true,
       interactiveBorder: 10,
       theme: 'quarto',
-      placement: 'bottom-start'
+      placement: 'bottom-start',
     };
+    if (contentFn) {
+      config.content = contentFn;
+    }
+    if (onTriggerFn) {
+      config.onTrigger = onTriggerFn;
+    }
+    if (onUntriggerFn) {
+      config.onUntrigger = onUntriggerFn;
+    }
     window.tippy(el, config); 
   }
   const noterefs = window.document.querySelectorAll('a[role="doc-noteref"]');
@@ -249,7 +282,130 @@ <h1>Understanding the Complexity of Proteome!</h1>
       try { href = new URL(href).hash; } catch {}
       const id = href.replace(/^#\/?/, "");
       const note = window.document.getElementById(id);
-      return note.innerHTML;
+      if (note) {
+        return note.innerHTML;
+      } else {
+        return "";
+      }
+    });
+  }
+  const xrefs = window.document.querySelectorAll('a.quarto-xref');
+  const processXRef = (id, note) => {
+    // Strip column container classes
+    const stripColumnClz = (el) => {
+      el.classList.remove("page-full", "page-columns");
+      if (el.children) {
+        for (const child of el.children) {
+          stripColumnClz(child);
+        }
+      }
+    }
+    stripColumnClz(note)
+    if (id === null || id.startsWith('sec-')) {
+      // Special case sections, only their first couple elements
+      const container = document.createElement("div");
+      if (note.children && note.children.length > 2) {
+        container.appendChild(note.children[0].cloneNode(true));
+        for (let i = 1; i < note.children.length; i++) {
+          const child = note.children[i];
+          if (child.tagName === "P" && child.innerText === "") {
+            continue;
+          } else {
+            container.appendChild(child.cloneNode(true));
+            break;
+          }
+        }
+        if (window.Quarto?.typesetMath) {
+          window.Quarto.typesetMath(container);
+        }
+        return container.innerHTML
+      } else {
+        if (window.Quarto?.typesetMath) {
+          window.Quarto.typesetMath(note);
+        }
+        return note.innerHTML;
+      }
+    } else {
+      // Remove any anchor links if they are present
+      const anchorLink = note.querySelector('a.anchorjs-link');
+      if (anchorLink) {
+        anchorLink.remove();
+      }
+      if (window.Quarto?.typesetMath) {
+        window.Quarto.typesetMath(note);
+      }
+      // TODO in 1.5, we should make sure this works without a callout special case
+      if (note.classList.contains("callout")) {
+        return note.outerHTML;
+      } else {
+        return note.innerHTML;
+      }
+    }
+  }
+  for (var i=0; i<xrefs.length; i++) {
+    const xref = xrefs[i];
+    tippyHover(xref, undefined, function(instance) {
+      instance.disable();
+      let url = xref.getAttribute('href');
+      let hash = undefined; 
+      if (url.startsWith('#')) {
+        hash = url;
+      } else {
+        try { hash = new URL(url).hash; } catch {}
+      }
+      if (hash) {
+        const id = hash.replace(/^#\/?/, "");
+        const note = window.document.getElementById(id);
+        if (note !== null) {
+          try {
+            const html = processXRef(id, note.cloneNode(true));
+            instance.setContent(html);
+          } finally {
+            instance.enable();
+            instance.show();
+          }
+        } else {
+          // See if we can fetch this
+          fetch(url.split('#')[0])
+          .then(res => res.text())
+          .then(html => {
+            const parser = new DOMParser();
+            const htmlDoc = parser.parseFromString(html, "text/html");
+            const note = htmlDoc.getElementById(id);
+            if (note !== null) {
+              const html = processXRef(id, note);
+              instance.setContent(html);
+            } 
+          }).finally(() => {
+            instance.enable();
+            instance.show();
+          });
+        }
+      } else {
+        // See if we can fetch a full url (with no hash to target)
+        // This is a special case and we should probably do some content thinning / targeting
+        fetch(url)
+        .then(res => res.text())
+        .then(html => {
+          const parser = new DOMParser();
+          const htmlDoc = parser.parseFromString(html, "text/html");
+          const note = htmlDoc.querySelector('main.content');
+          if (note !== null) {
+            // This should only happen for chapter cross references
+            // (since there is no id in the URL)
+            // remove the first header
+            if (note.children.length > 0 && note.children[0].tagName === "HEADER") {
+              note.children[0].remove();
+            }
+            const html = processXRef(null, note);
+            instance.setContent(html);
+          } 
+        }).finally(() => {
+          instance.enable();
+          instance.show();
+        });
+      }
+    }, function(instance) {
     });
   }
       let selectedAnnoteEl;
@@ -293,6 +449,7 @@ <h1>Understanding the Complexity of Proteome!</h1>
             }
             div.style.top = top - 2 + "px";
             div.style.height = height + 4 + "px";
+            div.style.left = 0;
             let gutterDiv = window.document.getElementById("code-annotation-line-highlight-gutter");
             if (gutterDiv === null) {
               gutterDiv = window.document.createElement("div");
@@ -318,6 +475,32 @@ <h1>Understanding the Complexity of Proteome!</h1>
         });
         selectedAnnoteEl = undefined;
       };
+        // Handle positioning of the toggle
+    window.addEventListener(
+      "resize",
+      throttle(() => {
+        elRect = undefined;
+        if (selectedAnnoteEl) {
+          selectCodeLines(selectedAnnoteEl);
+        }
+      }, 10)
+    );
+    function throttle(fn, ms) {
+    let throttle = false;
+    let timer;
+      return (...args) => {
+        if(!throttle) { // first call gets through
+            fn.apply(this, args);
+            throttle = true;
+        } else { // all the others get throttled
+            if(timer) clearTimeout(timer); // cancel #2
+            timer = setTimeout(() => {
+              fn.apply(this, args);
+              timer = throttle = false;
+            }, ms);
+        }
+      };
+    }
       // Attach click handler to the DT
       const annoteDls = window.document.querySelectorAll('dt[data-target-cell]');
       for (const annoteDlNode of annoteDls) {
@@ -381,4 +564,5 @@ <h1>Understanding the Complexity of Proteome!</h1>
 
 
 
+
 </body></html>
\ No newline at end of file
diff --git a/docs/search.json b/docs/search.json
index 5e160c3..3c0e974 100644
--- a/docs/search.json
+++ b/docs/search.json
@@ -4,7 +4,7 @@
     "href": "index.html",
     "title": "Understanding the Complexity of Proteome!",
     "section": "",
-    "text": "Understanding the Complexity of Proteome!\nHi, I’m Santosh D. Bhosale, pharmacist by training and currently working as an associate biomedical scientist at Cedars-Sinai Precision biomarker laboratories, Los Angeles, CA, USA.\nUsing the versatility of mass spectrometry-based proteomics, I am exploring the properties of biologically important proteins.\nPrecisely, I work on mass spectrometry-based proteomics technologies to address the questions related to biomedical research. These includes not only the qualitative and quantitative measurement of proteins, but also their post-translational modifications and interactions with other proteins. I use computational methods to understand the complexity of proteins."
+    "text": "Understanding the Complexity of Proteome!\nHi, I’m Santosh D. Bhosale, pharmacist by training and currently working as an associate biomedical scientist at Cedars-Sinai Precision biomarker laboratories, Los Angeles, CA, USA.\nUsing the versatility of mass spectrometry-based proteomics, I am exploring the properties of biologically important proteins.\nPrecisely, I work on mass spectrometry-based proteomics technologies to address the questions related to biomedical research. These includes not only the qualitative and quantitative measurement of proteins, but also their post-translational modifications and interactions with other proteins. I use variety of computational methods to understand the complexity of proteins."
   },
   {
     "objectID": "blog/Serum-Proteomics-Pre-diabetic/index.html",
@@ -25,7 +25,7 @@
     "href": "blog/index.html",
     "title": "Santosh D. Bhosale",
     "section": "",
-    "text": "Welcome to my blog, here, you will find a collection of posts for some of the previously published articles!\nThe snapshot of my research work is visualized in the following WordCloud using Scholar Googler shiny app. This app extracts information from research publications by using individual’s Google Scholar ID.\n\n\n\n\n\n\n\n\n\n  \n\n\n\n\nAP-MS to Study FOSL Related Proteins Interactome\n\n\n\n\n\n\n\npublications\n\n\nT cells\n\n\n\n\n\n\n\n\n\n\n\nSeptember 16, 2021\n\n\n\n\n\n\n  \n\n\n\n\nMass Spectrometry Based Serum Proteomics\n\n\n\n\n\n\n\npublications\n\n\nbook chapter\n\n\n\n\n\n\n\n\n\n\n\nNovember 18, 2020\n\n\n\n\n\n\n  \n\n\n\n\nSerum Proteomics Atherosclerosis\n\n\n\n\n\n\n\npublications\n\n\nserum\n\n\n\n\n\n\n\n\n\n\n\nNovember 11, 2020\n\n\n\n\n\n\n  \n\n\n\n\nSerum Proteomics Pre diabetic\n\n\n\n\n\n\n\npublications\n\n\nserum\n\n\n\n\n\n\n\n\n\n\n\nOctober 27, 2020\n\n\n\n\n\n\nNo matching items"
+    "text": "Welcome to my blog, here, you will find a collection of posts for some of the previously published articles!\nThe snapshot of my research work is visualized in the following WordCloud using Scholar Googler shiny app. This app extracts information from research publications by using individual’s Google Scholar ID.\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\nAP-MS to Study FOSL Related Proteins Interactome\n\n\n\n\n\n\npublications\n\n\nT cells\n\n\n\n\n\n\n\n\n\nSeptember 16, 2021\n\n\n\n\n\n\n\n\n\n\n\n\nMass Spectrometry Based Serum Proteomics\n\n\n\n\n\n\npublications\n\n\nbook chapter\n\n\n\n\n\n\n\n\n\nNovember 18, 2020\n\n\n\n\n\n\n\n\n\n\n\n\nSerum Proteomics Atherosclerosis\n\n\n\n\n\n\npublications\n\n\nserum\n\n\n\n\n\n\n\n\n\nNovember 11, 2020\n\n\n\n\n\n\n\n\n\n\n\n\nSerum Proteomics Pre diabetic\n\n\n\n\n\n\npublications\n\n\nserum\n\n\n\n\n\n\n\n\n\nOctober 27, 2020\n\n\n\n\n\n\nNo matching items"
   },
   {
     "objectID": "about/index.html",
diff --git a/docs/site_libs/bootstrap/bootstrap-icons.css b/docs/site_libs/bootstrap/bootstrap-icons.css
index 94f1940..285e444 100644
--- a/docs/site_libs/bootstrap/bootstrap-icons.css
+++ b/docs/site_libs/bootstrap/bootstrap-icons.css
@@ -1,8 +1,14 @@
+/*!
+ * Bootstrap Icons v1.11.1 (https://icons.getbootstrap.com/)
+ * Copyright 2019-2023 The Bootstrap Authors
+ * Licensed under MIT (https://github.com/twbs/icons/blob/main/LICENSE)
+ */
+
 @font-face {
   font-display: block;
   font-family: "bootstrap-icons";
   src: 
-url("./bootstrap-icons.woff?2ab2cbbe07fcebb53bdaa7313bb290f2") format("woff");
+url("./bootstrap-icons.woff?2820a3852bdb9a5832199cc61cec4e65") format("woff");
 }
 
 .bi::before,
@@ -441,7 +447,6 @@ url("./bootstrap-icons.woff?2ab2cbbe07fcebb53bdaa7313bb290f2") format("woff");
 .bi-cloud-fog2::before { content: "\f2a2"; }
 .bi-cloud-hail-fill::before { content: "\f2a3"; }
 .bi-cloud-hail::before { content: "\f2a4"; }
-.bi-cloud-haze-1::before { content: "\f2a5"; }
 .bi-cloud-haze-fill::before { content: "\f2a6"; }
 .bi-cloud-haze::before { content: "\f2a7"; }
 .bi-cloud-haze2-fill::before { content: "\f2a8"; }
@@ -1437,21 +1442,16 @@ url("./bootstrap-icons.woff?2ab2cbbe07fcebb53bdaa7313bb290f2") format("woff");
 .bi-dpad::before { content: "\f687"; }
 .bi-ear-fill::before { content: "\f688"; }
 .bi-ear::before { content: "\f689"; }
-.bi-envelope-check-1::before { content: "\f68a"; }
 .bi-envelope-check-fill::before { content: "\f68b"; }
 .bi-envelope-check::before { content: "\f68c"; }
-.bi-envelope-dash-1::before { content: "\f68d"; }
 .bi-envelope-dash-fill::before { content: "\f68e"; }
 .bi-envelope-dash::before { content: "\f68f"; }
-.bi-envelope-exclamation-1::before { content: "\f690"; }
 .bi-envelope-exclamation-fill::before { content: "\f691"; }
 .bi-envelope-exclamation::before { content: "\f692"; }
 .bi-envelope-plus-fill::before { content: "\f693"; }
 .bi-envelope-plus::before { content: "\f694"; }
-.bi-envelope-slash-1::before { content: "\f695"; }
 .bi-envelope-slash-fill::before { content: "\f696"; }
 .bi-envelope-slash::before { content: "\f697"; }
-.bi-envelope-x-1::before { content: "\f698"; }
 .bi-envelope-x-fill::before { content: "\f699"; }
 .bi-envelope-x::before { content: "\f69a"; }
 .bi-explicit-fill::before { content: "\f69b"; }
@@ -1461,8 +1461,6 @@ url("./bootstrap-icons.woff?2ab2cbbe07fcebb53bdaa7313bb290f2") format("woff");
 .bi-list-columns-reverse::before { content: "\f69f"; }
 .bi-list-columns::before { content: "\f6a0"; }
 .bi-meta::before { content: "\f6a1"; }
-.bi-mortorboard-fill::before { content: "\f6a2"; }
-.bi-mortorboard::before { content: "\f6a3"; }
 .bi-nintendo-switch::before { content: "\f6a4"; }
 .bi-pc-display-horizontal::before { content: "\f6a5"; }
 .bi-pc-display::before { content: "\f6a6"; }
@@ -1481,7 +1479,6 @@ url("./bootstrap-icons.woff?2ab2cbbe07fcebb53bdaa7313bb290f2") format("woff");
 .bi-send-check::before { content: "\f6b3"; }
 .bi-send-dash-fill::before { content: "\f6b4"; }
 .bi-send-dash::before { content: "\f6b5"; }
-.bi-send-exclamation-1::before { content: "\f6b6"; }
 .bi-send-exclamation-fill::before { content: "\f6b7"; }
 .bi-send-exclamation::before { content: "\f6b8"; }
 .bi-send-fill::before { content: "\f6b9"; }
@@ -1493,7 +1490,6 @@ url("./bootstrap-icons.woff?2ab2cbbe07fcebb53bdaa7313bb290f2") format("woff");
 .bi-send-x::before { content: "\f6bf"; }
 .bi-send::before { content: "\f6c0"; }
 .bi-steam::before { content: "\f6c1"; }
-.bi-terminal-dash-1::before { content: "\f6c2"; }
 .bi-terminal-dash::before { content: "\f6c3"; }
 .bi-terminal-plus::before { content: "\f6c4"; }
 .bi-terminal-split::before { content: "\f6c5"; }
@@ -1523,7 +1519,6 @@ url("./bootstrap-icons.woff?2ab2cbbe07fcebb53bdaa7313bb290f2") format("woff");
 .bi-usb-symbol::before { content: "\f6dd"; }
 .bi-usb::before { content: "\f6de"; }
 .bi-boombox-fill::before { content: "\f6df"; }
-.bi-displayport-1::before { content: "\f6e0"; }
 .bi-displayport::before { content: "\f6e1"; }
 .bi-gpu-card::before { content: "\f6e2"; }
 .bi-memory::before { content: "\f6e3"; }
@@ -1536,8 +1531,6 @@ url("./bootstrap-icons.woff?2ab2cbbe07fcebb53bdaa7313bb290f2") format("woff");
 .bi-pci-card::before { content: "\f6ea"; }
 .bi-router-fill::before { content: "\f6eb"; }
 .bi-router::before { content: "\f6ec"; }
-.bi-ssd-fill::before { content: "\f6ed"; }
-.bi-ssd::before { content: "\f6ee"; }
 .bi-thunderbolt-fill::before { content: "\f6ef"; }
 .bi-thunderbolt::before { content: "\f6f0"; }
 .bi-usb-drive-fill::before { content: "\f6f1"; }
@@ -1644,7 +1637,6 @@ url("./bootstrap-icons.woff?2ab2cbbe07fcebb53bdaa7313bb290f2") format("woff");
 .bi-filetype-pdf::before { content: "\f756"; }
 .bi-filetype-php::before { content: "\f757"; }
 .bi-filetype-png::before { content: "\f758"; }
-.bi-filetype-ppt-1::before { content: "\f759"; }
 .bi-filetype-ppt::before { content: "\f75a"; }
 .bi-filetype-psd::before { content: "\f75b"; }
 .bi-filetype-py::before { content: "\f75c"; }
@@ -1660,7 +1652,6 @@ url("./bootstrap-icons.woff?2ab2cbbe07fcebb53bdaa7313bb290f2") format("woff");
 .bi-filetype-txt::before { content: "\f766"; }
 .bi-filetype-wav::before { content: "\f767"; }
 .bi-filetype-woff::before { content: "\f768"; }
-.bi-filetype-xls-1::before { content: "\f769"; }
 .bi-filetype-xls::before { content: "\f76a"; }
 .bi-filetype-xml::before { content: "\f76b"; }
 .bi-filetype-yml::before { content: "\f76c"; }
@@ -1703,56 +1694,38 @@ url("./bootstrap-icons.woff?2ab2cbbe07fcebb53bdaa7313bb290f2") format("woff");
 .bi-filetype-json::before { content: "\f791"; }
 .bi-filetype-pptx::before { content: "\f792"; }
 .bi-filetype-xlsx::before { content: "\f793"; }
-.bi-1-circle-1::before { content: "\f794"; }
-.bi-1-circle-fill-1::before { content: "\f795"; }
 .bi-1-circle-fill::before { content: "\f796"; }
 .bi-1-circle::before { content: "\f797"; }
 .bi-1-square-fill::before { content: "\f798"; }
 .bi-1-square::before { content: "\f799"; }
-.bi-2-circle-1::before { content: "\f79a"; }
-.bi-2-circle-fill-1::before { content: "\f79b"; }
 .bi-2-circle-fill::before { content: "\f79c"; }
 .bi-2-circle::before { content: "\f79d"; }
 .bi-2-square-fill::before { content: "\f79e"; }
 .bi-2-square::before { content: "\f79f"; }
-.bi-3-circle-1::before { content: "\f7a0"; }
-.bi-3-circle-fill-1::before { content: "\f7a1"; }
 .bi-3-circle-fill::before { content: "\f7a2"; }
 .bi-3-circle::before { content: "\f7a3"; }
 .bi-3-square-fill::before { content: "\f7a4"; }
 .bi-3-square::before { content: "\f7a5"; }
-.bi-4-circle-1::before { content: "\f7a6"; }
-.bi-4-circle-fill-1::before { content: "\f7a7"; }
 .bi-4-circle-fill::before { content: "\f7a8"; }
 .bi-4-circle::before { content: "\f7a9"; }
 .bi-4-square-fill::before { content: "\f7aa"; }
 .bi-4-square::before { content: "\f7ab"; }
-.bi-5-circle-1::before { content: "\f7ac"; }
-.bi-5-circle-fill-1::before { content: "\f7ad"; }
 .bi-5-circle-fill::before { content: "\f7ae"; }
 .bi-5-circle::before { content: "\f7af"; }
 .bi-5-square-fill::before { content: "\f7b0"; }
 .bi-5-square::before { content: "\f7b1"; }
-.bi-6-circle-1::before { content: "\f7b2"; }
-.bi-6-circle-fill-1::before { content: "\f7b3"; }
 .bi-6-circle-fill::before { content: "\f7b4"; }
 .bi-6-circle::before { content: "\f7b5"; }
 .bi-6-square-fill::before { content: "\f7b6"; }
 .bi-6-square::before { content: "\f7b7"; }
-.bi-7-circle-1::before { content: "\f7b8"; }
-.bi-7-circle-fill-1::before { content: "\f7b9"; }
 .bi-7-circle-fill::before { content: "\f7ba"; }
 .bi-7-circle::before { content: "\f7bb"; }
 .bi-7-square-fill::before { content: "\f7bc"; }
 .bi-7-square::before { content: "\f7bd"; }
-.bi-8-circle-1::before { content: "\f7be"; }
-.bi-8-circle-fill-1::before { content: "\f7bf"; }
 .bi-8-circle-fill::before { content: "\f7c0"; }
 .bi-8-circle::before { content: "\f7c1"; }
 .bi-8-square-fill::before { content: "\f7c2"; }
 .bi-8-square::before { content: "\f7c3"; }
-.bi-9-circle-1::before { content: "\f7c4"; }
-.bi-9-circle-fill-1::before { content: "\f7c5"; }
 .bi-9-circle-fill::before { content: "\f7c6"; }
 .bi-9-circle::before { content: "\f7c7"; }
 .bi-9-square-fill::before { content: "\f7c8"; }
@@ -1771,8 +1744,6 @@ url("./bootstrap-icons.woff?2ab2cbbe07fcebb53bdaa7313bb290f2") format("woff");
 .bi-browser-edge::before { content: "\f7d5"; }
 .bi-browser-firefox::before { content: "\f7d6"; }
 .bi-browser-safari::before { content: "\f7d7"; }
-.bi-c-circle-1::before { content: "\f7d8"; }
-.bi-c-circle-fill-1::before { content: "\f7d9"; }
 .bi-c-circle-fill::before { content: "\f7da"; }
 .bi-c-circle::before { content: "\f7db"; }
 .bi-c-square-fill::before { content: "\f7dc"; }
@@ -1783,8 +1754,6 @@ url("./bootstrap-icons.woff?2ab2cbbe07fcebb53bdaa7313bb290f2") format("woff");
 .bi-car-front::before { content: "\f7e1"; }
 .bi-cassette-fill::before { content: "\f7e2"; }
 .bi-cassette::before { content: "\f7e3"; }
-.bi-cc-circle-1::before { content: "\f7e4"; }
-.bi-cc-circle-fill-1::before { content: "\f7e5"; }
 .bi-cc-circle-fill::before { content: "\f7e6"; }
 .bi-cc-circle::before { content: "\f7e7"; }
 .bi-cc-square-fill::before { content: "\f7e8"; }
@@ -1803,8 +1772,6 @@ url("./bootstrap-icons.woff?2ab2cbbe07fcebb53bdaa7313bb290f2") format("woff");
 .bi-filetype-sql::before { content: "\f7f5"; }
 .bi-fire::before { content: "\f7f6"; }
 .bi-google-play::before { content: "\f7f7"; }
-.bi-h-circle-1::before { content: "\f7f8"; }
-.bi-h-circle-fill-1::before { content: "\f7f9"; }
 .bi-h-circle-fill::before { content: "\f7fa"; }
 .bi-h-circle::before { content: "\f7fb"; }
 .bi-h-square-fill::before { content: "\f7fc"; }
@@ -1813,8 +1780,6 @@ url("./bootstrap-icons.woff?2ab2cbbe07fcebb53bdaa7313bb290f2") format("woff");
 .bi-lungs-fill::before { content: "\f7ff"; }
 .bi-lungs::before { content: "\f800"; }
 .bi-microsoft-teams::before { content: "\f801"; }
-.bi-p-circle-1::before { content: "\f802"; }
-.bi-p-circle-fill-1::before { content: "\f803"; }
 .bi-p-circle-fill::before { content: "\f804"; }
 .bi-p-circle::before { content: "\f805"; }
 .bi-p-square-fill::before { content: "\f806"; }
@@ -1823,8 +1788,6 @@ url("./bootstrap-icons.woff?2ab2cbbe07fcebb53bdaa7313bb290f2") format("woff");
 .bi-pass::before { content: "\f809"; }
 .bi-prescription::before { content: "\f80a"; }
 .bi-prescription2::before { content: "\f80b"; }
-.bi-r-circle-1::before { content: "\f80c"; }
-.bi-r-circle-fill-1::before { content: "\f80d"; }
 .bi-r-circle-fill::before { content: "\f80e"; }
 .bi-r-circle::before { content: "\f80f"; }
 .bi-r-square-fill::before { content: "\f810"; }
@@ -2016,3 +1979,100 @@ url("./bootstrap-icons.woff?2ab2cbbe07fcebb53bdaa7313bb290f2") format("woff");
 .bi-sina-weibo::before { content: "\f8ca"; }
 .bi-tencent-qq::before { content: "\f8cb"; }
 .bi-wikipedia::before { content: "\f8cc"; }
+.bi-alphabet-uppercase::before { content: "\f2a5"; }
+.bi-alphabet::before { content: "\f68a"; }
+.bi-amazon::before { content: "\f68d"; }
+.bi-arrows-collapse-vertical::before { content: "\f690"; }
+.bi-arrows-expand-vertical::before { content: "\f695"; }
+.bi-arrows-vertical::before { content: "\f698"; }
+.bi-arrows::before { content: "\f6a2"; }
+.bi-ban-fill::before { content: "\f6a3"; }
+.bi-ban::before { content: "\f6b6"; }
+.bi-bing::before { content: "\f6c2"; }
+.bi-cake::before { content: "\f6e0"; }
+.bi-cake2::before { content: "\f6ed"; }
+.bi-cookie::before { content: "\f6ee"; }
+.bi-copy::before { content: "\f759"; }
+.bi-crosshair::before { content: "\f769"; }
+.bi-crosshair2::before { content: "\f794"; }
+.bi-emoji-astonished-fill::before { content: "\f795"; }
+.bi-emoji-astonished::before { content: "\f79a"; }
+.bi-emoji-grimace-fill::before { content: "\f79b"; }
+.bi-emoji-grimace::before { content: "\f7a0"; }
+.bi-emoji-grin-fill::before { content: "\f7a1"; }
+.bi-emoji-grin::before { content: "\f7a6"; }
+.bi-emoji-surprise-fill::before { content: "\f7a7"; }
+.bi-emoji-surprise::before { content: "\f7ac"; }
+.bi-emoji-tear-fill::before { content: "\f7ad"; }
+.bi-emoji-tear::before { content: "\f7b2"; }
+.bi-envelope-arrow-down-fill::before { content: "\f7b3"; }
+.bi-envelope-arrow-down::before { content: "\f7b8"; }
+.bi-envelope-arrow-up-fill::before { content: "\f7b9"; }
+.bi-envelope-arrow-up::before { content: "\f7be"; }
+.bi-feather::before { content: "\f7bf"; }
+.bi-feather2::before { content: "\f7c4"; }
+.bi-floppy-fill::before { content: "\f7c5"; }
+.bi-floppy::before { content: "\f7d8"; }
+.bi-floppy2-fill::before { content: "\f7d9"; }
+.bi-floppy2::before { content: "\f7e4"; }
+.bi-gitlab::before { content: "\f7e5"; }
+.bi-highlighter::before { content: "\f7f8"; }
+.bi-marker-tip::before { content: "\f802"; }
+.bi-nvme-fill::before { content: "\f803"; }
+.bi-nvme::before { content: "\f80c"; }
+.bi-opencollective::before { content: "\f80d"; }
+.bi-pci-card-network::before { content: "\f8cd"; }
+.bi-pci-card-sound::before { content: "\f8ce"; }
+.bi-radar::before { content: "\f8cf"; }
+.bi-send-arrow-down-fill::before { content: "\f8d0"; }
+.bi-send-arrow-down::before { content: "\f8d1"; }
+.bi-send-arrow-up-fill::before { content: "\f8d2"; }
+.bi-send-arrow-up::before { content: "\f8d3"; }
+.bi-sim-slash-fill::before { content: "\f8d4"; }
+.bi-sim-slash::before { content: "\f8d5"; }
+.bi-sourceforge::before { content: "\f8d6"; }
+.bi-substack::before { content: "\f8d7"; }
+.bi-threads-fill::before { content: "\f8d8"; }
+.bi-threads::before { content: "\f8d9"; }
+.bi-transparency::before { content: "\f8da"; }
+.bi-twitter-x::before { content: "\f8db"; }
+.bi-type-h4::before { content: "\f8dc"; }
+.bi-type-h5::before { content: "\f8dd"; }
+.bi-type-h6::before { content: "\f8de"; }
+.bi-backpack-fill::before { content: "\f8df"; }
+.bi-backpack::before { content: "\f8e0"; }
+.bi-backpack2-fill::before { content: "\f8e1"; }
+.bi-backpack2::before { content: "\f8e2"; }
+.bi-backpack3-fill::before { content: "\f8e3"; }
+.bi-backpack3::before { content: "\f8e4"; }
+.bi-backpack4-fill::before { content: "\f8e5"; }
+.bi-backpack4::before { content: "\f8e6"; }
+.bi-brilliance::before { content: "\f8e7"; }
+.bi-cake-fill::before { content: "\f8e8"; }
+.bi-cake2-fill::before { content: "\f8e9"; }
+.bi-duffle-fill::before { content: "\f8ea"; }
+.bi-duffle::before { content: "\f8eb"; }
+.bi-exposure::before { content: "\f8ec"; }
+.bi-gender-neuter::before { content: "\f8ed"; }
+.bi-highlights::before { content: "\f8ee"; }
+.bi-luggage-fill::before { content: "\f8ef"; }
+.bi-luggage::before { content: "\f8f0"; }
+.bi-mailbox-flag::before { content: "\f8f1"; }
+.bi-mailbox2-flag::before { content: "\f8f2"; }
+.bi-noise-reduction::before { content: "\f8f3"; }
+.bi-passport-fill::before { content: "\f8f4"; }
+.bi-passport::before { content: "\f8f5"; }
+.bi-person-arms-up::before { content: "\f8f6"; }
+.bi-person-raised-hand::before { content: "\f8f7"; }
+.bi-person-standing-dress::before { content: "\f8f8"; }
+.bi-person-standing::before { content: "\f8f9"; }
+.bi-person-walking::before { content: "\f8fa"; }
+.bi-person-wheelchair::before { content: "\f8fb"; }
+.bi-shadows::before { content: "\f8fc"; }
+.bi-suitcase-fill::before { content: "\f8fd"; }
+.bi-suitcase-lg-fill::before { content: "\f8fe"; }
+.bi-suitcase-lg::before { content: "\f8ff"; }
+.bi-suitcase::before { content: "\f900"; }
+.bi-suitcase2-fill::before { content: "\f901"; }
+.bi-suitcase2::before { content: "\f902"; }
+.bi-vignette::before { content: "\f903"; }
diff --git a/docs/site_libs/bootstrap/bootstrap-icons.woff b/docs/site_libs/bootstrap/bootstrap-icons.woff
index 18d21d4..dbeeb05 100644
Binary files a/docs/site_libs/bootstrap/bootstrap-icons.woff and b/docs/site_libs/bootstrap/bootstrap-icons.woff differ
diff --git a/docs/site_libs/bootstrap/bootstrap.min.css b/docs/site_libs/bootstrap/bootstrap.min.css
index f5fd358..4d521d3 100644
--- a/docs/site_libs/bootstrap/bootstrap.min.css
+++ b/docs/site_libs/bootstrap/bootstrap.min.css
@@ -1,10 +1,12 @@
 /*!
- * Bootstrap v5.1.3 (https://getbootstrap.com/)
- * Copyright 2011-2021 The Bootstrap Authors
- * Copyright 2011-2021 Twitter, Inc.
+ * Bootstrap  v5.3.1 (https://getbootstrap.com/)
+ * Copyright 2011-2023 The Bootstrap Authors
  * Licensed under MIT (https://github.com/twbs/bootstrap/blob/main/LICENSE)
- */:root{--bs-blue: #2780e3;--bs-indigo: #6610f2;--bs-purple: #170C3A;--bs-pink: #A52C60;--bs-red: #CF4446;--bs-orange: #EE6A24;--bs-yellow: #F6D645;--bs-green: #118230;--bs-teal: #068194;--bs-cyan: #3093CF;--bs-white: #ffffff;--bs-gray: #6c757d;--bs-gray-dark: #373a3c;--bs-gray-100: #f8f9fa;--bs-gray-200: #e9ecef;--bs-gray-300: #dee2e6;--bs-gray-400: #ced4da;--bs-gray-500: #adb5bd;--bs-gray-600: #6c757d;--bs-gray-700: #495057;--bs-gray-800: #373a3c;--bs-gray-900: #212529;--bs-default: #495057;--bs-primary: #068194;--bs-secondary: #495057;--bs-success: #118230;--bs-info: #3093CF;--bs-warning: #EE6A24;--bs-danger: #CF4446;--bs-light: #ced4da;--bs-dark: #000000;--bs-default-rgb: 73, 80, 87;--bs-primary-rgb: 6, 129, 148;--bs-secondary-rgb: 73, 80, 87;--bs-success-rgb: 17, 130, 48;--bs-info-rgb: 48, 147, 207;--bs-warning-rgb: 238, 106, 36;--bs-danger-rgb: 207, 68, 70;--bs-light-rgb: 206, 212, 218;--bs-dark-rgb: 0, 0, 0;--bs-white-rgb: 255, 255, 255;--bs-black-rgb: 0, 0, 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.offcanvas{position:static;z-index:auto;flex-grow:1;-webkit-flex-grow:1;width:auto !important;height:auto !important;visibility:visible !important;background-color:rgba(0,0,0,0) !important;border:0 !important;transform:none !important;transition:none}.navbar-expand-xxl .offcanvas .offcanvas-header{display:none}.navbar-expand-xxl .offcanvas .offcanvas-body{display:flex;display:-webkit-flex;flex-grow:0;-webkit-flex-grow:0;padding:0;overflow-y:visible}}.navbar-expand{flex-wrap:nowrap;-webkit-flex-wrap:nowrap;justify-content:flex-start;-webkit-justify-content:flex-start}.navbar-expand .navbar-nav{flex-direction:row;-webkit-flex-direction:row}.navbar-expand .navbar-nav .dropdown-menu{position:absolute}.navbar-expand .navbar-nav .nav-link{padding-right:var(--bs-navbar-nav-link-padding-x);padding-left:var(--bs-navbar-nav-link-padding-x)}.navbar-expand .navbar-nav-scroll{overflow:visible}.navbar-expand .navbar-collapse{display:flex !important;display:-webkit-flex 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xmlns='http://www.w3.org/2000/svg' viewBox='0 0 30 30'%3e%3cpath stroke='rgba%28255, 255, 255, 0.7%29' stroke-linecap='round' stroke-miterlimit='10' stroke-width='2' d='M4 7h22M4 15h22M4 23h22'/%3e%3c/svg%3e")}[data-bs-theme=dark] .navbar-toggler-icon{--bs-navbar-toggler-icon-bg: url("data:image/svg+xml,%3csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 30 30'%3e%3cpath stroke='rgba%28255, 255, 255, 0.7%29' stroke-linecap='round' stroke-miterlimit='10' stroke-width='2' d='M4 7h22M4 15h22M4 23h22'/%3e%3c/svg%3e")}.card{--bs-card-spacer-y: 1rem;--bs-card-spacer-x: 1rem;--bs-card-title-spacer-y: 0.5rem;--bs-card-title-color: ;--bs-card-subtitle-color: ;--bs-card-border-width: 1px;--bs-card-border-color: rgba(0, 0, 0, 0.175);--bs-card-border-radius: 0.25rem;--bs-card-box-shadow: ;--bs-card-inner-border-radius: calc(0.25rem - 1px);--bs-card-cap-padding-y: 0.5rem;--bs-card-cap-padding-x: 1rem;--bs-card-cap-bg: rgba(52, 58, 64, 0.25);--bs-card-cap-color: ;--bs-card-height: ;--bs-card-color: ;--bs-card-bg: #ffffff;--bs-card-img-overlay-padding: 1rem;--bs-card-group-margin: 0.75rem;position:relative;display:flex;display:-webkit-flex;flex-direction:column;-webkit-flex-direction:column;min-width:0;height:var(--bs-card-height);color:var(--bs-body-color);word-wrap:break-word;background-color:var(--bs-card-bg);background-clip:border-box;border:var(--bs-card-border-width) solid var(--bs-card-border-color)}.card>hr{margin-right:0;margin-left:0}.card>.list-group{border-top:inherit;border-bottom:inherit}.card>.list-group:first-child{border-top-width:0}.card>.list-group:last-child{border-bottom-width:0}.card>.card-header+.list-group,.card>.list-group+.card-footer{border-top:0}.card-body{flex:1 1 auto;-webkit-flex:1 1 auto;padding:var(--bs-card-spacer-y) var(--bs-card-spacer-x);color:var(--bs-card-color)}.card-title{margin-bottom:var(--bs-card-title-spacer-y);color:var(--bs-card-title-color)}.card-subtitle{margin-top:calc(-0.5*var(--bs-card-title-spacer-y));margin-bottom:0;color:var(--bs-card-subtitle-color)}.card-text:last-child{margin-bottom:0}.card-link:hover{text-decoration:none;-webkit-text-decoration:none;-moz-text-decoration:none;-ms-text-decoration:none;-o-text-decoration:none}.card-link+.card-link{margin-left:var(--bs-card-spacer-x)}.card-header{padding:var(--bs-card-cap-padding-y) var(--bs-card-cap-padding-x);margin-bottom:0;color:var(--bs-card-cap-color);background-color:var(--bs-card-cap-bg);border-bottom:var(--bs-card-border-width) solid var(--bs-card-border-color)}.card-footer{padding:var(--bs-card-cap-padding-y) var(--bs-card-cap-padding-x);color:var(--bs-card-cap-color);background-color:var(--bs-card-cap-bg);border-top:var(--bs-card-border-width) solid var(--bs-card-border-color)}.card-header-tabs{margin-right:calc(-0.5*var(--bs-card-cap-padding-x));margin-bottom:calc(-1*var(--bs-card-cap-padding-y));margin-left:calc(-0.5*var(--bs-card-cap-padding-x));border-bottom:0}.card-header-tabs .nav-link.active{background-color:var(--bs-card-bg);border-bottom-color:var(--bs-card-bg)}.card-header-pills{margin-right:calc(-0.5*var(--bs-card-cap-padding-x));margin-left:calc(-0.5*var(--bs-card-cap-padding-x))}.card-img-overlay{position:absolute;top:0;right:0;bottom:0;left:0;padding:var(--bs-card-img-overlay-padding)}.card-img,.card-img-top,.card-img-bottom{width:100%}.card-group>.card{margin-bottom:var(--bs-card-group-margin)}@media(min-width: 576px){.card-group{display:flex;display:-webkit-flex;flex-flow:row wrap;-webkit-flex-flow:row wrap}.card-group>.card{flex:1 0 0%;-webkit-flex:1 0 0%;margin-bottom:0}.card-group>.card+.card{margin-left:0;border-left:0}}.accordion{--bs-accordion-color: #495057;--bs-accordion-bg: #ffffff;--bs-accordion-transition: color 0.15s ease-in-out, background-color 0.15s ease-in-out, border-color 0.15s ease-in-out, box-shadow 0.15s ease-in-out, border-radius 0.15s ease;--bs-accordion-border-color: #dee2e6;--bs-accordion-border-width: 1px;--bs-accordion-border-radius: 0.25rem;--bs-accordion-inner-border-radius: calc(0.25rem - 1px);--bs-accordion-btn-padding-x: 1.25rem;--bs-accordion-btn-padding-y: 1rem;--bs-accordion-btn-color: #495057;--bs-accordion-btn-bg: #ffffff;--bs-accordion-btn-icon: url("data:image/svg+xml,%3csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 16 16' fill='%23495057'%3e%3cpath fill-rule='evenodd' d='M1.646 4.646a.5.5 0 0 1 .708 0L8 10.293l5.646-5.647a.5.5 0 0 1 .708.708l-6 6a.5.5 0 0 1-.708 0l-6-6a.5.5 0 0 1 0-.708z'/%3e%3c/svg%3e");--bs-accordion-btn-icon-width: 1.25rem;--bs-accordion-btn-icon-transform: rotate(-180deg);--bs-accordion-btn-icon-transition: transform 0.2s ease-in-out;--bs-accordion-btn-active-icon: url("data:image/svg+xml,%3csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 16 16' fill='%2302343b'%3e%3cpath fill-rule='evenodd' d='M1.646 4.646a.5.5 0 0 1 .708 0L8 10.293l5.646-5.647a.5.5 0 0 1 .708.708l-6 6a.5.5 0 0 1-.708 0l-6-6a.5.5 0 0 1 0-.708z'/%3e%3c/svg%3e");--bs-accordion-btn-focus-border-color: #068194;--bs-accordion-btn-focus-box-shadow: 0 0 0 0.25rem rgba(6, 129, 148, 0.25);--bs-accordion-body-padding-x: 1.25rem;--bs-accordion-body-padding-y: 1rem;--bs-accordion-active-color: #02343b;--bs-accordion-active-bg: #cde6ea}.accordion-button{position:relative;display:flex;display:-webkit-flex;align-items:center;-webkit-align-items:center;width:100%;padding:var(--bs-accordion-btn-padding-y) var(--bs-accordion-btn-padding-x);font-size:1rem;color:var(--bs-accordion-btn-color);text-align:left;background-color:var(--bs-accordion-btn-bg);border:0;overflow-anchor:none;transition:var(--bs-accordion-transition)}@media(prefers-reduced-motion: reduce){.accordion-button{transition:none}}.accordion-button:not(.collapsed){color:var(--bs-accordion-active-color);background-color:var(--bs-accordion-active-bg);box-shadow:inset 0 calc(-1*var(--bs-accordion-border-width)) 0 var(--bs-accordion-border-color)}.accordion-button:not(.collapsed)::after{background-image:var(--bs-accordion-btn-active-icon);transform:var(--bs-accordion-btn-icon-transform)}.accordion-button::after{flex-shrink:0;-webkit-flex-shrink:0;width:var(--bs-accordion-btn-icon-width);height:var(--bs-accordion-btn-icon-width);margin-left:auto;content:"";background-image:var(--bs-accordion-btn-icon);background-repeat:no-repeat;background-size:var(--bs-accordion-btn-icon-width);transition:var(--bs-accordion-btn-icon-transition)}@media(prefers-reduced-motion: reduce){.accordion-button::after{transition:none}}.accordion-button:hover{z-index:2}.accordion-button:focus{z-index:3;border-color:var(--bs-accordion-btn-focus-border-color);outline:0;box-shadow:var(--bs-accordion-btn-focus-box-shadow)}.accordion-header{margin-bottom:0}.accordion-item{color:var(--bs-accordion-color);background-color:var(--bs-accordion-bg);border:var(--bs-accordion-border-width) solid var(--bs-accordion-border-color)}.accordion-item:not(:first-of-type){border-top:0}.accordion-body{padding:var(--bs-accordion-body-padding-y) var(--bs-accordion-body-padding-x)}.accordion-flush .accordion-collapse{border-width:0}.accordion-flush .accordion-item{border-right:0;border-left:0}.accordion-flush .accordion-item:first-child{border-top:0}.accordion-flush .accordion-item:last-child{border-bottom:0}[data-bs-theme=dark] .accordion-button::after{--bs-accordion-btn-icon: url("data:image/svg+xml,%3csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 16 16' fill='%236ab3bf'%3e%3cpath fill-rule='evenodd' d='M1.646 4.646a.5.5 0 0 1 .708 0L8 10.293l5.646-5.647a.5.5 0 0 1 .708.708l-6 6a.5.5 0 0 1-.708 0l-6-6a.5.5 0 0 1 0-.708z'/%3e%3c/svg%3e");--bs-accordion-btn-active-icon: url("data:image/svg+xml,%3csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 16 16' fill='%236ab3bf'%3e%3cpath fill-rule='evenodd' d='M1.646 4.646a.5.5 0 0 1 .708 0L8 10.293l5.646-5.647a.5.5 0 0 1 .708.708l-6 6a.5.5 0 0 1-.708 0l-6-6a.5.5 0 0 1 0-.708z'/%3e%3c/svg%3e")}.breadcrumb{--bs-breadcrumb-padding-x: 0;--bs-breadcrumb-padding-y: 0;--bs-breadcrumb-margin-bottom: 1rem;--bs-breadcrumb-bg: ;--bs-breadcrumb-border-radius: ;--bs-breadcrumb-divider-color: rgba(73, 80, 87, 0.75);--bs-breadcrumb-item-padding-x: 0.5rem;--bs-breadcrumb-item-active-color: rgba(73, 80, 87, 0.75);display:flex;display:-webkit-flex;flex-wrap:wrap;-webkit-flex-wrap:wrap;padding:var(--bs-breadcrumb-padding-y) var(--bs-breadcrumb-padding-x);margin-bottom:var(--bs-breadcrumb-margin-bottom);font-size:var(--bs-breadcrumb-font-size);list-style:none;background-color:var(--bs-breadcrumb-bg)}.breadcrumb-item+.breadcrumb-item{padding-left:var(--bs-breadcrumb-item-padding-x)}.breadcrumb-item+.breadcrumb-item::before{float:left;padding-right:var(--bs-breadcrumb-item-padding-x);color:var(--bs-breadcrumb-divider-color);content:var(--bs-breadcrumb-divider, ">") /* rtl: var(--bs-breadcrumb-divider, ">") */}.breadcrumb-item.active{color:var(--bs-breadcrumb-item-active-color)}.pagination{--bs-pagination-padding-x: 0.75rem;--bs-pagination-padding-y: 0.375rem;--bs-pagination-font-size:1rem;--bs-pagination-color: #068194;--bs-pagination-bg: #ffffff;--bs-pagination-border-width: 1px;--bs-pagination-border-color: #dee2e6;--bs-pagination-border-radius: 0.25rem;--bs-pagination-hover-color: #CF4446;--bs-pagination-hover-bg: #f8f9fa;--bs-pagination-hover-border-color: #dee2e6;--bs-pagination-focus-color: #CF4446;--bs-pagination-focus-bg: #e9ecef;--bs-pagination-focus-box-shadow: 0 0 0 0.25rem rgba(6, 129, 148, 0.25);--bs-pagination-active-color: #ffffff;--bs-pagination-active-bg: #068194;--bs-pagination-active-border-color: #068194;--bs-pagination-disabled-color: rgba(73, 80, 87, 0.75);--bs-pagination-disabled-bg: #e9ecef;--bs-pagination-disabled-border-color: #dee2e6;display:flex;display:-webkit-flex;padding-left:0;list-style:none}.page-link{position:relative;display:block;padding:var(--bs-pagination-padding-y) var(--bs-pagination-padding-x);font-size:var(--bs-pagination-font-size);color:var(--bs-pagination-color);background-color:var(--bs-pagination-bg);border:var(--bs-pagination-border-width) solid var(--bs-pagination-border-color);transition:color .15s ease-in-out,background-color .15s ease-in-out,border-color .15s ease-in-out,box-shadow .15s ease-in-out}@media(prefers-reduced-motion: reduce){.page-link{transition:none}}.page-link:hover{z-index:2;color:var(--bs-pagination-hover-color);text-decoration:none;-webkit-text-decoration:none;-moz-text-decoration:none;-ms-text-decoration:none;-o-text-decoration:none;background-color:var(--bs-pagination-hover-bg);border-color:var(--bs-pagination-hover-border-color)}.page-link:focus{z-index:3;color:var(--bs-pagination-focus-color);background-color:var(--bs-pagination-focus-bg);outline:0;box-shadow:var(--bs-pagination-focus-box-shadow)}.page-link.active,.active>.page-link{z-index:3;color:var(--bs-pagination-active-color);background-color:var(--bs-pagination-active-bg);border-color:var(--bs-pagination-active-border-color)}.page-link.disabled,.disabled>.page-link{color:var(--bs-pagination-disabled-color);pointer-events:none;background-color:var(--bs-pagination-disabled-bg);border-color:var(--bs-pagination-disabled-border-color)}.page-item:not(:first-child) .page-link{margin-left:calc(1px*-1)}.pagination-lg{--bs-pagination-padding-x: 1.5rem;--bs-pagination-padding-y: 0.75rem;--bs-pagination-font-size:1.25rem;--bs-pagination-border-radius: 0.5rem}.pagination-sm{--bs-pagination-padding-x: 0.5rem;--bs-pagination-padding-y: 0.25rem;--bs-pagination-font-size:0.875rem;--bs-pagination-border-radius: 0.2em}.badge{--bs-badge-padding-x: 0.65em;--bs-badge-padding-y: 0.35em;--bs-badge-font-size:0.75em;--bs-badge-font-weight: 700;--bs-badge-color: #ffffff;--bs-badge-border-radius: 0.25rem;display:inline-block;padding:var(--bs-badge-padding-y) var(--bs-badge-padding-x);font-size:var(--bs-badge-font-size);font-weight:var(--bs-badge-font-weight);line-height:1;color:var(--bs-badge-color);text-align:center;white-space:nowrap;vertical-align:baseline}.badge:empty{display:none}.btn .badge{position:relative;top:-1px}.alert{--bs-alert-bg: transparent;--bs-alert-padding-x: 1rem;--bs-alert-padding-y: 1rem;--bs-alert-margin-bottom: 1rem;--bs-alert-color: inherit;--bs-alert-border-color: transparent;--bs-alert-border: 1px solid var(--bs-alert-border-color);--bs-alert-border-radius: 0.25rem;--bs-alert-link-color: inherit;position:relative;padding:var(--bs-alert-padding-y) var(--bs-alert-padding-x);margin-bottom:var(--bs-alert-margin-bottom);color:var(--bs-alert-color);background-color:var(--bs-alert-bg);border:var(--bs-alert-border)}.alert-heading{color:inherit}.alert-link{font-weight:700;color:var(--bs-alert-link-color)}.alert-dismissible{padding-right:3rem}.alert-dismissible .btn-close{position:absolute;top:0;right:0;z-index:2;padding:1.25rem 1rem}.alert-default{--bs-alert-color: var(--bs-default-text-emphasis);--bs-alert-bg: var(--bs-default-bg-subtle);--bs-alert-border-color: var(--bs-default-border-subtle);--bs-alert-link-color: var(--bs-default-text-emphasis)}.alert-primary{--bs-alert-color: var(--bs-primary-text-emphasis);--bs-alert-bg: var(--bs-primary-bg-subtle);--bs-alert-border-color: var(--bs-primary-border-subtle);--bs-alert-link-color: var(--bs-primary-text-emphasis)}.alert-secondary{--bs-alert-color: var(--bs-secondary-text-emphasis);--bs-alert-bg: var(--bs-secondary-bg-subtle);--bs-alert-border-color: var(--bs-secondary-border-subtle);--bs-alert-link-color: var(--bs-secondary-text-emphasis)}.alert-success{--bs-alert-color: var(--bs-success-text-emphasis);--bs-alert-bg: var(--bs-success-bg-subtle);--bs-alert-border-color: var(--bs-success-border-subtle);--bs-alert-link-color: var(--bs-success-text-emphasis)}.alert-info{--bs-alert-color: var(--bs-info-text-emphasis);--bs-alert-bg: var(--bs-info-bg-subtle);--bs-alert-border-color: var(--bs-info-border-subtle);--bs-alert-link-color: var(--bs-info-text-emphasis)}.alert-warning{--bs-alert-color: var(--bs-warning-text-emphasis);--bs-alert-bg: var(--bs-warning-bg-subtle);--bs-alert-border-color: var(--bs-warning-border-subtle);--bs-alert-link-color: var(--bs-warning-text-emphasis)}.alert-danger{--bs-alert-color: var(--bs-danger-text-emphasis);--bs-alert-bg: var(--bs-danger-bg-subtle);--bs-alert-border-color: var(--bs-danger-border-subtle);--bs-alert-link-color: var(--bs-danger-text-emphasis)}.alert-light{--bs-alert-color: var(--bs-light-text-emphasis);--bs-alert-bg: var(--bs-light-bg-subtle);--bs-alert-border-color: var(--bs-light-border-subtle);--bs-alert-link-color: var(--bs-light-text-emphasis)}.alert-dark{--bs-alert-color: var(--bs-dark-text-emphasis);--bs-alert-bg: var(--bs-dark-bg-subtle);--bs-alert-border-color: var(--bs-dark-border-subtle);--bs-alert-link-color: var(--bs-dark-text-emphasis)}@keyframes progress-bar-stripes{0%{background-position-x:1rem}}.progress,.progress-stacked{--bs-progress-height: 1rem;--bs-progress-font-size:0.75rem;--bs-progress-bg: #dee2e6;--bs-progress-border-radius: 0.25rem;--bs-progress-box-shadow: inset 0 1px 2px rgba(0, 0, 0, 0.075);--bs-progress-bar-color: #ffffff;--bs-progress-bar-bg: #068194;--bs-progress-bar-transition: width 0.6s ease;display:flex;display:-webkit-flex;height:var(--bs-progress-height);overflow:hidden;font-size:var(--bs-progress-font-size);background-color:var(--bs-progress-bg)}.progress-bar{display:flex;display:-webkit-flex;flex-direction:column;-webkit-flex-direction:column;justify-content:center;-webkit-justify-content:center;overflow:hidden;color:var(--bs-progress-bar-color);text-align:center;white-space:nowrap;background-color:var(--bs-progress-bar-bg);transition:var(--bs-progress-bar-transition)}@media(prefers-reduced-motion: reduce){.progress-bar{transition:none}}.progress-bar-striped{background-image:linear-gradient(45deg, rgba(255, 255, 255, 0.15) 25%, transparent 25%, transparent 50%, rgba(255, 255, 255, 0.15) 50%, rgba(255, 255, 255, 0.15) 75%, transparent 75%, transparent);background-size:var(--bs-progress-height) var(--bs-progress-height)}.progress-stacked>.progress{overflow:visible}.progress-stacked>.progress>.progress-bar{width:100%}.progress-bar-animated{animation:1s linear infinite progress-bar-stripes}@media(prefers-reduced-motion: reduce){.progress-bar-animated{animation:none}}.list-group{--bs-list-group-color: #495057;--bs-list-group-bg: #212529;--bs-list-group-border-color: transparent;--bs-list-group-border-width: 1px;--bs-list-group-border-radius: 0.25rem;--bs-list-group-item-padding-x: 1rem;--bs-list-group-item-padding-y: 0.5rem;--bs-list-group-action-color: rgba(73, 80, 87, 0.75);--bs-list-group-action-hover-color: #000000;--bs-list-group-action-hover-bg: #383f45;--bs-list-group-action-active-color: #495057;--bs-list-group-action-active-bg: #e9ecef;--bs-list-group-disabled-color: #65727e;--bs-list-group-disabled-bg: #212529;--bs-list-group-active-color: #ffffff;--bs-list-group-active-bg: #212529;--bs-list-group-active-border-color: #212529;display:flex;display:-webkit-flex;flex-direction:column;-webkit-flex-direction:column;padding-left:0;margin-bottom:0}.list-group-numbered{list-style-type:none;counter-reset:section}.list-group-numbered>.list-group-item::before{content:counters(section, ".") ". ";counter-increment:section}.list-group-item-action{width:100%;color:var(--bs-list-group-action-color);text-align:inherit}.list-group-item-action:hover,.list-group-item-action:focus{z-index:1;color:var(--bs-list-group-action-hover-color);text-decoration:none;background-color:var(--bs-list-group-action-hover-bg)}.list-group-item-action:active{color:var(--bs-list-group-action-active-color);background-color:var(--bs-list-group-action-active-bg)}.list-group-item{position:relative;display:block;padding:var(--bs-list-group-item-padding-y) var(--bs-list-group-item-padding-x);color:var(--bs-list-group-color);background-color:var(--bs-list-group-bg);border:var(--bs-list-group-border-width) solid var(--bs-list-group-border-color)}.list-group-item.disabled,.list-group-item:disabled{color:var(--bs-list-group-disabled-color);pointer-events:none;background-color:var(--bs-list-group-disabled-bg)}.list-group-item.active{z-index:2;color:var(--bs-list-group-active-color);background-color:var(--bs-list-group-active-bg);border-color:var(--bs-list-group-active-border-color)}.list-group-item+.list-group-item{border-top-width:0}.list-group-item+.list-group-item.active{margin-top:calc(-1*var(--bs-list-group-border-width));border-top-width:var(--bs-list-group-border-width)}.list-group-horizontal{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal>.list-group-item.active{margin-top:0}.list-group-horizontal>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal>.list-group-item+.list-group-item.active{margin-left:calc(-1*var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}@media(min-width: 576px){.list-group-horizontal-sm{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal-sm>.list-group-item.active{margin-top:0}.list-group-horizontal-sm>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal-sm>.list-group-item+.list-group-item.active{margin-left:calc(-1*var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}}@media(min-width: 768px){.list-group-horizontal-md{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal-md>.list-group-item.active{margin-top:0}.list-group-horizontal-md>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal-md>.list-group-item+.list-group-item.active{margin-left:calc(-1*var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}}@media(min-width: 992px){.list-group-horizontal-lg{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal-lg>.list-group-item.active{margin-top:0}.list-group-horizontal-lg>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal-lg>.list-group-item+.list-group-item.active{margin-left:calc(-1*var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}}@media(min-width: 1200px){.list-group-horizontal-xl{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal-xl>.list-group-item.active{margin-top:0}.list-group-horizontal-xl>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal-xl>.list-group-item+.list-group-item.active{margin-left:calc(-1*var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}}@media(min-width: 1400px){.list-group-horizontal-xxl{flex-direction:row;-webkit-flex-direction:row}.list-group-horizontal-xxl>.list-group-item.active{margin-top:0}.list-group-horizontal-xxl>.list-group-item+.list-group-item{border-top-width:var(--bs-list-group-border-width);border-left-width:0}.list-group-horizontal-xxl>.list-group-item+.list-group-item.active{margin-left:calc(-1*var(--bs-list-group-border-width));border-left-width:var(--bs-list-group-border-width)}}.list-group-flush>.list-group-item{border-width:0 0 var(--bs-list-group-border-width)}.list-group-flush>.list-group-item:last-child{border-bottom-width:0}.list-group-item-default{--bs-list-group-color: var(--bs-default-text-emphasis);--bs-list-group-bg: var(--bs-default-bg-subtle);--bs-list-group-border-color: var(--bs-default-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-default-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-default-border-subtle);--bs-list-group-active-color: var(--bs-default-bg-subtle);--bs-list-group-active-bg: var(--bs-default-text-emphasis);--bs-list-group-active-border-color: var(--bs-default-text-emphasis)}.list-group-item-primary{--bs-list-group-color: var(--bs-primary-text-emphasis);--bs-list-group-bg: var(--bs-primary-bg-subtle);--bs-list-group-border-color: var(--bs-primary-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-primary-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-primary-border-subtle);--bs-list-group-active-color: var(--bs-primary-bg-subtle);--bs-list-group-active-bg: var(--bs-primary-text-emphasis);--bs-list-group-active-border-color: var(--bs-primary-text-emphasis)}.list-group-item-secondary{--bs-list-group-color: var(--bs-secondary-text-emphasis);--bs-list-group-bg: var(--bs-secondary-bg-subtle);--bs-list-group-border-color: var(--bs-secondary-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-secondary-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-secondary-border-subtle);--bs-list-group-active-color: var(--bs-secondary-bg-subtle);--bs-list-group-active-bg: var(--bs-secondary-text-emphasis);--bs-list-group-active-border-color: var(--bs-secondary-text-emphasis)}.list-group-item-success{--bs-list-group-color: var(--bs-success-text-emphasis);--bs-list-group-bg: var(--bs-success-bg-subtle);--bs-list-group-border-color: var(--bs-success-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-success-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-success-border-subtle);--bs-list-group-active-color: var(--bs-success-bg-subtle);--bs-list-group-active-bg: var(--bs-success-text-emphasis);--bs-list-group-active-border-color: var(--bs-success-text-emphasis)}.list-group-item-info{--bs-list-group-color: var(--bs-info-text-emphasis);--bs-list-group-bg: var(--bs-info-bg-subtle);--bs-list-group-border-color: var(--bs-info-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-info-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-info-border-subtle);--bs-list-group-active-color: var(--bs-info-bg-subtle);--bs-list-group-active-bg: var(--bs-info-text-emphasis);--bs-list-group-active-border-color: var(--bs-info-text-emphasis)}.list-group-item-warning{--bs-list-group-color: var(--bs-warning-text-emphasis);--bs-list-group-bg: var(--bs-warning-bg-subtle);--bs-list-group-border-color: var(--bs-warning-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-warning-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-warning-border-subtle);--bs-list-group-active-color: var(--bs-warning-bg-subtle);--bs-list-group-active-bg: var(--bs-warning-text-emphasis);--bs-list-group-active-border-color: var(--bs-warning-text-emphasis)}.list-group-item-danger{--bs-list-group-color: var(--bs-danger-text-emphasis);--bs-list-group-bg: var(--bs-danger-bg-subtle);--bs-list-group-border-color: var(--bs-danger-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-danger-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-danger-border-subtle);--bs-list-group-active-color: var(--bs-danger-bg-subtle);--bs-list-group-active-bg: var(--bs-danger-text-emphasis);--bs-list-group-active-border-color: var(--bs-danger-text-emphasis)}.list-group-item-light{--bs-list-group-color: var(--bs-light-text-emphasis);--bs-list-group-bg: var(--bs-light-bg-subtle);--bs-list-group-border-color: var(--bs-light-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-light-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-light-border-subtle);--bs-list-group-active-color: var(--bs-light-bg-subtle);--bs-list-group-active-bg: var(--bs-light-text-emphasis);--bs-list-group-active-border-color: var(--bs-light-text-emphasis)}.list-group-item-dark{--bs-list-group-color: var(--bs-dark-text-emphasis);--bs-list-group-bg: var(--bs-dark-bg-subtle);--bs-list-group-border-color: var(--bs-dark-border-subtle);--bs-list-group-action-hover-color: var(--bs-emphasis-color);--bs-list-group-action-hover-bg: var(--bs-dark-border-subtle);--bs-list-group-action-active-color: var(--bs-emphasis-color);--bs-list-group-action-active-bg: var(--bs-dark-border-subtle);--bs-list-group-active-color: var(--bs-dark-bg-subtle);--bs-list-group-active-bg: var(--bs-dark-text-emphasis);--bs-list-group-active-border-color: var(--bs-dark-text-emphasis)}.btn-close{--bs-btn-close-color: #000000;--bs-btn-close-bg: url("data:image/svg+xml,%3csvg xmlns='http://www.w3.org/2000/svg' viewBox='0 0 16 16' fill='%23000000'%3e%3cpath d='M.293.293a1 1 0 0 1 1.414 0L8 6.586 14.293.293a1 1 0 1 1 1.414 1.414L9.414 8l6.293 6.293a1 1 0 0 1-1.414 1.414L8 9.414l-6.293 6.293a1 1 0 0 1-1.414-1.414L6.586 8 .293 1.707a1 1 0 0 1 0-1.414z'/%3e%3c/svg%3e");--bs-btn-close-opacity: 0.5;--bs-btn-close-hover-opacity: 0.75;--bs-btn-close-focus-shadow: 0 0 0 0.25rem rgba(6, 129, 148, 0.25);--bs-btn-close-focus-opacity: 1;--bs-btn-close-disabled-opacity: 0.25;--bs-btn-close-white-filter: invert(1) grayscale(100%) brightness(200%);box-sizing:content-box;width:1em;height:1em;padding:.25em .25em;color:var(--bs-btn-close-color);background:rgba(0,0,0,0) var(--bs-btn-close-bg) center/1em auto no-repeat;border:0;opacity:var(--bs-btn-close-opacity)}.btn-close:hover{color:var(--bs-btn-close-color);text-decoration:none;opacity:var(--bs-btn-close-hover-opacity)}.btn-close:focus{outline:0;box-shadow:var(--bs-btn-close-focus-shadow);opacity:var(--bs-btn-close-focus-opacity)}.btn-close:disabled,.btn-close.disabled{pointer-events:none;user-select:none;-webkit-user-select:none;-moz-user-select:none;-ms-user-select:none;-o-user-select:none;opacity:var(--bs-btn-close-disabled-opacity)}.btn-close-white{filter:var(--bs-btn-close-white-filter)}[data-bs-theme=dark] .btn-close{filter:var(--bs-btn-close-white-filter)}.toast{--bs-toast-zindex: 1090;--bs-toast-padding-x: 0.75rem;--bs-toast-padding-y: 0.5rem;--bs-toast-spacing: 1.5rem;--bs-toast-max-width: 350px;--bs-toast-font-size:0.875rem;--bs-toast-color: ;--bs-toast-bg: rgba(255, 255, 255, 0.85);--bs-toast-border-width: 1px;--bs-toast-border-color: rgba(0, 0, 0, 0.175);--bs-toast-border-radius: 0.25rem;--bs-toast-box-shadow: 0 0.5rem 1rem rgba(0, 0, 0, 0.15);--bs-toast-header-color: rgba(73, 80, 87, 0.75);--bs-toast-header-bg: rgba(255, 255, 255, 0.85);--bs-toast-header-border-color: rgba(0, 0, 0, 0.175);width:var(--bs-toast-max-width);max-width:100%;font-size:var(--bs-toast-font-size);color:var(--bs-toast-color);pointer-events:auto;background-color:var(--bs-toast-bg);background-clip:padding-box;border:var(--bs-toast-border-width) solid var(--bs-toast-border-color);box-shadow:var(--bs-toast-box-shadow)}.toast.showing{opacity:0}.toast:not(.show){display:none}.toast-container{--bs-toast-zindex: 1090;position:absolute;z-index:var(--bs-toast-zindex);width:max-content;width:-webkit-max-content;width:-moz-max-content;width:-ms-max-content;width:-o-max-content;max-width:100%;pointer-events:none}.toast-container>:not(:last-child){margin-bottom:var(--bs-toast-spacing)}.toast-header{display:flex;display:-webkit-flex;align-items:center;-webkit-align-items:center;padding:var(--bs-toast-padding-y) var(--bs-toast-padding-x);color:var(--bs-toast-header-color);background-color:var(--bs-toast-header-bg);background-clip:padding-box;border-bottom:var(--bs-toast-border-width) solid var(--bs-toast-header-border-color)}.toast-header .btn-close{margin-right:calc(-0.5*var(--bs-toast-padding-x));margin-left:var(--bs-toast-padding-x)}.toast-body{padding:var(--bs-toast-padding-x);word-wrap:break-word}.modal{--bs-modal-zindex: 1055;--bs-modal-width: 500px;--bs-modal-padding: 1rem;--bs-modal-margin: 0.5rem;--bs-modal-color: ;--bs-modal-bg: #ffffff;--bs-modal-border-color: rgba(0, 0, 0, 0.175);--bs-modal-border-width: 1px;--bs-modal-border-radius: 0.5rem;--bs-modal-box-shadow: 0 0.125rem 0.25rem rgba(0, 0, 0, 0.075);--bs-modal-inner-border-radius: calc(0.5rem - 1px);--bs-modal-header-padding-x: 1rem;--bs-modal-header-padding-y: 1rem;--bs-modal-header-padding: 1rem 1rem;--bs-modal-header-border-color: #dee2e6;--bs-modal-header-border-width: 1px;--bs-modal-title-line-height: 1.5;--bs-modal-footer-gap: 0.5rem;--bs-modal-footer-bg: ;--bs-modal-footer-border-color: #dee2e6;--bs-modal-footer-border-width: 1px;position:fixed;top:0;left:0;z-index:var(--bs-modal-zindex);display:none;width:100%;height:100%;overflow-x:hidden;overflow-y:auto;outline:0}.modal-dialog{position:relative;width:auto;margin:var(--bs-modal-margin);pointer-events:none}.modal.fade .modal-dialog{transition:transform .3s ease-out;transform:translate(0, -50px)}@media(prefers-reduced-motion: reduce){.modal.fade .modal-dialog{transition:none}}.modal.show .modal-dialog{transform:none}.modal.modal-static .modal-dialog{transform:scale(1.02)}.modal-dialog-scrollable{height:calc(100% - var(--bs-modal-margin)*2)}.modal-dialog-scrollable .modal-content{max-height:100%;overflow:hidden}.modal-dialog-scrollable .modal-body{overflow-y:auto}.modal-dialog-centered{display:flex;display:-webkit-flex;align-items:center;-webkit-align-items:center;min-height:calc(100% - var(--bs-modal-margin)*2)}.modal-content{position:relative;display:flex;display:-webkit-flex;flex-direction:column;-webkit-flex-direction:column;width:100%;color:var(--bs-modal-color);pointer-events:auto;background-color:var(--bs-modal-bg);background-clip:padding-box;border:var(--bs-modal-border-width) solid var(--bs-modal-border-color);outline:0}.modal-backdrop{--bs-backdrop-zindex: 1050;--bs-backdrop-bg: #000000;--bs-backdrop-opacity: 0.5;position:fixed;top:0;left:0;z-index:var(--bs-backdrop-zindex);width:100vw;height:100vh;background-color:var(--bs-backdrop-bg)}.modal-backdrop.fade{opacity:0}.modal-backdrop.show{opacity:var(--bs-backdrop-opacity)}.modal-header{display:flex;display:-webkit-flex;flex-shrink:0;-webkit-flex-shrink:0;align-items:center;-webkit-align-items:center;justify-content:space-between;-webkit-justify-content:space-between;padding:var(--bs-modal-header-padding);border-bottom:var(--bs-modal-header-border-width) solid var(--bs-modal-header-border-color)}.modal-header .btn-close{padding:calc(var(--bs-modal-header-padding-y)*.5) calc(var(--bs-modal-header-padding-x)*.5);margin:calc(-0.5*var(--bs-modal-header-padding-y)) calc(-0.5*var(--bs-modal-header-padding-x)) calc(-0.5*var(--bs-modal-header-padding-y)) auto}.modal-title{margin-bottom:0;line-height:var(--bs-modal-title-line-height)}.modal-body{position:relative;flex:1 1 auto;-webkit-flex:1 1 auto;padding:var(--bs-modal-padding)}.modal-footer{display:flex;display:-webkit-flex;flex-shrink:0;-webkit-flex-shrink:0;flex-wrap:wrap;-webkit-flex-wrap:wrap;align-items:center;-webkit-align-items:center;justify-content:flex-end;-webkit-justify-content:flex-end;padding:calc(var(--bs-modal-padding) - var(--bs-modal-footer-gap)*.5);background-color:var(--bs-modal-footer-bg);border-top:var(--bs-modal-footer-border-width) solid var(--bs-modal-footer-border-color)}.modal-footer>*{margin:calc(var(--bs-modal-footer-gap)*.5)}@media(min-width: 576px){.modal{--bs-modal-margin: 1.75rem;--bs-modal-box-shadow: 0 0.5rem 1rem rgba(0, 0, 0, 0.15)}.modal-dialog{max-width:var(--bs-modal-width);margin-right:auto;margin-left:auto}.modal-sm{--bs-modal-width: 300px}}@media(min-width: 992px){.modal-lg,.modal-xl{--bs-modal-width: 800px}}@media(min-width: 1200px){.modal-xl{--bs-modal-width: 1140px}}.modal-fullscreen{width:100vw;max-width:none;height:100%;margin:0}.modal-fullscreen .modal-content{height:100%;border:0}.modal-fullscreen .modal-body{overflow-y:auto}@media(max-width: 575.98px){.modal-fullscreen-sm-down{width:100vw;max-width:none;height:100%;margin:0}.modal-fullscreen-sm-down .modal-content{height:100%;border:0}.modal-fullscreen-sm-down .modal-body{overflow-y:auto}}@media(max-width: 767.98px){.modal-fullscreen-md-down{width:100vw;max-width:none;height:100%;margin:0}.modal-fullscreen-md-down .modal-content{height:100%;border:0}.modal-fullscreen-md-down .modal-body{overflow-y:auto}}@media(max-width: 991.98px){.modal-fullscreen-lg-down{width:100vw;max-width:none;height:100%;margin:0}.modal-fullscreen-lg-down .modal-content{height:100%;border:0}.modal-fullscreen-lg-down .modal-body{overflow-y:auto}}@media(max-width: 1199.98px){.modal-fullscreen-xl-down{width:100vw;max-width:none;height:100%;margin:0}.modal-fullscreen-xl-down .modal-content{height:100%;border:0}.modal-fullscreen-xl-down .modal-body{overflow-y:auto}}@media(max-width: 1399.98px){.modal-fullscreen-xxl-down{width:100vw;max-width:none;height:100%;margin:0}.modal-fullscreen-xxl-down .modal-content{height:100%;border:0}.modal-fullscreen-xxl-down .modal-body{overflow-y:auto}}.tooltip{--bs-tooltip-zindex: 1080;--bs-tooltip-max-width: 200px;--bs-tooltip-padding-x: 0.5rem;--bs-tooltip-padding-y: 0.25rem;--bs-tooltip-margin: ;--bs-tooltip-font-size:0.875rem;--bs-tooltip-color: #ffffff;--bs-tooltip-bg: #000000;--bs-tooltip-border-radius: 0.25rem;--bs-tooltip-opacity: 0.9;--bs-tooltip-arrow-width: 0.8rem;--bs-tooltip-arrow-height: 0.4rem;z-index:var(--bs-tooltip-zindex);display:block;margin:var(--bs-tooltip-margin);font-family:system-ui,-apple-system,"Segoe UI",Roboto,"Helvetica Neue","Noto Sans","Liberation Sans",Arial,sans-serif,"Apple Color Emoji","Segoe UI Emoji","Segoe UI Symbol","Noto Color 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1rem)}.bslib-mb-spacing{margin-bottom:var(--bslib-mb-spacer)}.bslib-gap-spacing{gap:var(--bslib-mb-spacer)}.bslib-gap-spacing>.bslib-mb-spacing,.bslib-gap-spacing>.form-group,.bslib-gap-spacing>p,.bslib-gap-spacing>pre{margin-bottom:0}.html-fill-container>.html-fill-item.bslib-mb-spacing{margin-bottom:0}.tab-content>.tab-pane.html-fill-container{display:none}.tab-content>.active.html-fill-container{display:flex}.tab-content.html-fill-container{padding:0}.accordion .accordion-header{font-size:calc(1.29rem + 0.48vw);margin-top:0;margin-bottom:.5rem;font-weight:500;line-height:1.2;color:var(--bs-heading-color);margin-bottom:0}@media(min-width: 1200px){.accordion .accordion-header{font-size:1.65rem}}.accordion .accordion-icon:not(:empty){margin-right:.75rem;display:flex}.accordion .accordion-button:not(.collapsed){box-shadow:none}.accordion .accordion-button:not(.collapsed):focus{box-shadow:var(--bs-accordion-btn-focus-box-shadow)}.bslib-card{overflow:auto}.bslib-card .card-body+.card-body{padding-top:0}.bslib-card .card-body{overflow:auto}.bslib-card .card-body p{margin-top:0}.bslib-card .card-body p:last-child{margin-bottom:0}.bslib-card .card-body{max-height:var(--bslib-card-body-max-height, none)}.bslib-card[data-full-screen=true]>.card-body{max-height:var(--bslib-card-body-max-height-full-screen, none)}.bslib-card .card-header .form-group{margin-bottom:0}.bslib-card .card-header .selectize-control{margin-bottom:0}.bslib-card .card-header .selectize-control .item{margin-right:1.15rem}.bslib-card .card-footer{margin-top:auto}.bslib-card .bslib-navs-card-title{display:flex;flex-wrap:wrap;justify-content:space-between;align-items:center}.bslib-card .bslib-navs-card-title .nav{margin-left:auto}.bslib-card .bslib-sidebar-layout:not([data-bslib-sidebar-border=true]){border:none}.bslib-card 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+* we also add `bright-[color]-` synonyms for the `-[color]-intense` classes since
+* that seems to be what ansi_up emits
+*
+*/.ansi-black-fg{color:#3e424d}.ansi-black-bg{background-color:#3e424d}.ansi-black-intense-black,.ansi-bright-black-fg{color:#282c36}.ansi-black-intense-black,.ansi-bright-black-bg{background-color:#282c36}.ansi-red-fg{color:#e75c58}.ansi-red-bg{background-color:#e75c58}.ansi-red-intense-red,.ansi-bright-red-fg{color:#b22b31}.ansi-red-intense-red,.ansi-bright-red-bg{background-color:#b22b31}.ansi-green-fg{color:#00a250}.ansi-green-bg{background-color:#00a250}.ansi-green-intense-green,.ansi-bright-green-fg{color:#007427}.ansi-green-intense-green,.ansi-bright-green-bg{background-color:#007427}.ansi-yellow-fg{color:#ddb62b}.ansi-yellow-bg{background-color:#ddb62b}.ansi-yellow-intense-yellow,.ansi-bright-yellow-fg{color:#b27d12}.ansi-yellow-intense-yellow,.ansi-bright-yellow-bg{background-color:#b27d12}.ansi-blue-fg{color:#208ffb}.ansi-blue-bg{background-color:#208ffb}.ansi-blue-intense-blue,.ansi-bright-blue-fg{color:#0065ca}.ansi-blue-intense-blue,.ansi-bright-blue-bg{background-color:#0065ca}.ansi-magenta-fg{color:#d160c4}.ansi-magenta-bg{background-color:#d160c4}.ansi-magenta-intense-magenta,.ansi-bright-magenta-fg{color:#a03196}.ansi-magenta-intense-magenta,.ansi-bright-magenta-bg{background-color:#a03196}.ansi-cyan-fg{color:#60c6c8}.ansi-cyan-bg{background-color:#60c6c8}.ansi-cyan-intense-cyan,.ansi-bright-cyan-fg{color:#258f8f}.ansi-cyan-intense-cyan,.ansi-bright-cyan-bg{background-color:#258f8f}.ansi-white-fg{color:#c5c1b4}.ansi-white-bg{background-color:#c5c1b4}.ansi-white-intense-white,.ansi-bright-white-fg{color:#a1a6b2}.ansi-white-intense-white,.ansi-bright-white-bg{background-color:#a1a6b2}.ansi-default-inverse-fg{color:#fff}.ansi-default-inverse-bg{background-color:#000}.ansi-bold{font-weight:bold}.ansi-underline{text-decoration:underline}:root{--quarto-body-bg: 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td.gt_row{border-bottom-width:1px;border-bottom-color:var(--quarto-border-color);border-top-width:0px}table.gt_table tbody.gt_table_body{border-top-width:1px;border-bottom-width:1px;border-bottom-color:var(--quarto-border-color);border-top-color:currentColor}div.columns{display:initial;gap:initial}div.column{display:inline-block;overflow-x:initial;vertical-align:top;width:50%}.code-annotation-tip-content{word-wrap:break-word}.code-annotation-container-hidden{display:none !important}dl.code-annotation-container-grid{display:grid;grid-template-columns:min-content auto}dl.code-annotation-container-grid dt{grid-column:1}dl.code-annotation-container-grid dd{grid-column:2}pre.sourceCode.code-annotation-code{padding-right:0}code.sourceCode .code-annotation-anchor{z-index:100;position:relative;float:right;background-color:rgba(0,0,0,0)}input[type=checkbox]{margin-right:.5ch}:root{--mermaid-bg-color: #ffffff;--mermaid-edge-color: #495057;--mermaid-node-fg-color: #495057;--mermaid-fg-color: 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Be={placement:"bottom",modifiers:[],strategy:"absolute"};function Re(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];return!e.some((function(t){return!(t&&"function"==typeof t.getBoundingClientRect)}))}function We(t){void 0===t&&(t={});var e=t,i=e.defaultModifiers,n=void 0===i?[]:i,s=e.defaultOptions,o=void 0===s?Be:s;return function(t,e,i){void 0===i&&(i=o);var s,r,a={placement:"bottom",orderedModifiers:[],options:Object.assign({},Be,o),modifiersData:{},elements:{reference:t,popper:e},attributes:{},styles:{}},l=[],c=!1,h={state:a,setOptions:function(i){var s="function"==typeof i?i(a.options):i;d(),a.options=Object.assign({},o,a.options,s),a.scrollParents={reference:$t(t)?Ae(t):t.contextElement?Ae(t.contextElement):[],popper:Ae(e)};var r,c,u=function(t){var e=He(t);return Bt.reduce((function(t,i){return t.concat(e.filter((function(t){return t.phase===i})))}),[])}((r=[].concat(n,a.options.modifiers),c=r.reduce((function(t,e){var i=t[e.name];return t[e.name]=i?Object.assign({},i,e,{options:Object.assign({},i.options,e.options),data:Object.assign({},i.data,e.data)}):e,t}),{}),Object.keys(c).map((function(t){return c[t]}))));return a.orderedModifiers=u.filter((function(t){return t.enabled})),a.orderedModifiers.forEach((function(t){var e=t.name,i=t.options,n=void 0===i?{}:i,s=t.effect;if("function"==typeof s){var o=s({state:a,name:e,instance:h,options:n});l.push(o||function(){})}})),h.update()},forceUpdate:function(){if(!c){var t=a.elements,e=t.reference,i=t.popper;if(Re(e,i)){a.rects={reference:Me(e,te(i),"fixed"===a.options.strategy),popper:Kt(i)},a.reset=!1,a.placement=a.options.placement,a.orderedModifiers.forEach((function(t){return a.modifiersData[t.name]=Object.assign({},t.data)}));for(var n=0;n<a.orderedModifiers.length;n++)if(!0!==a.reset){var s=a.orderedModifiers[n],o=s.fn,r=s.options,l=void 0===r?{}:r,d=s.name;"function"==typeof o&&(a=o({state:a,options:l,name:d,instance:h})||a)}else a.reset=!1,n=-1}}},update:(s=function(){return new Promise((function(t){h.forceUpdate(),t(a)}))},function(){return r||(r=new Promise((function(t){Promise.resolve().then((function(){r=void 0,t(s())}))}))),r}),destroy:function(){d(),c=!0}};if(!Re(t,e))return h;function d(){l.forEach((function(t){return t()})),l=[]}return h.setOptions(i).then((function(t){!c&&i.onFirstUpdate&&i.onFirstUpdate(t)})),h}}var $e=We(),ze=We({defaultModifiers:[pe,Pe,ue,Ft]}),qe=We({defaultModifiers:[pe,Pe,ue,Ft,Ie,xe,je,le,Ne]});const Fe=Object.freeze({__proto__:null,popperGenerator:We,detectOverflow:ke,createPopperBase:$e,createPopper:qe,createPopperLite:ze,top:mt,bottom:gt,right:_t,left:bt,auto:vt,basePlacements:yt,start:wt,end:Et,clippingParents:At,viewport:Tt,popper:Ot,reference:Ct,variationPlacements:kt,placements:Lt,beforeRead:xt,read:Dt,afterRead:St,beforeMain:Nt,main:It,afterMain:Pt,beforeWrite:jt,write:Mt,afterWrite:Ht,modifierPhases:Bt,applyStyles:Ft,arrow:le,computeStyles:ue,eventListeners:pe,flip:xe,hide:Ne,offset:Ie,popperOffsets:Pe,preventOverflow:je}),Ue="dropdown",Ve="Escape",Ke="Space",Xe="ArrowUp",Ye="ArrowDown",Qe=new RegExp("ArrowUp|ArrowDown|Escape"),Ge="click.bs.dropdown.data-api",Ze="keydown.bs.dropdown.data-api",Je="show",ti='[data-bs-toggle="dropdown"]',ei=".dropdown-menu",ii=m()?"top-end":"top-start",ni=m()?"top-start":"top-end",si=m()?"bottom-end":"bottom-start",oi=m()?"bottom-start":"bottom-end",ri=m()?"left-start":"right-start",ai=m()?"right-start":"left-start",li={offset:[0,2],boundary:"clippingParents",reference:"toggle",display:"dynamic",popperConfig:null,autoClose:!0},ci={offset:"(array|string|function)",boundary:"(string|element)",reference:"(string|element|object)",display:"string",popperConfig:"(null|object|function)",autoClose:"(boolean|string)"};class hi extends B{constructor(t,e){super(t),this._popper=null,this._config=this._getConfig(e),this._menu=this._getMenuElement(),this._inNavbar=this._detectNavbar()}static get Default(){return li}static get DefaultType(){return ci}static get NAME(){return Ue}toggle(){return this._isShown()?this.hide():this.show()}show(){if(c(this._element)||this._isShown(this._menu))return;const t={relatedTarget:this._element};if(j.trigger(this._element,"show.bs.dropdown",t).defaultPrevented)return;const e=hi.getParentFromElement(this._element);this._inNavbar?U.setDataAttribute(this._menu,"popper","none"):this._createPopper(e),"ontouchstart"in document.documentElement&&!e.closest(".navbar-nav")&&[].concat(...document.body.children).forEach((t=>j.on(t,"mouseover",d))),this._element.focus(),this._element.setAttribute("aria-expanded",!0),this._menu.classList.add(Je),this._element.classList.add(Je),j.trigger(this._element,"shown.bs.dropdown",t)}hide(){if(c(this._element)||!this._isShown(this._menu))return;const t={relatedTarget:this._element};this._completeHide(t)}dispose(){this._popper&&this._popper.destroy(),super.dispose()}update(){this._inNavbar=this._detectNavbar(),this._popper&&this._popper.update()}_completeHide(t){j.trigger(this._element,"hide.bs.dropdown",t).defaultPrevented||("ontouchstart"in document.documentElement&&[].concat(...document.body.children).forEach((t=>j.off(t,"mouseover",d))),this._popper&&this._popper.destroy(),this._menu.classList.remove(Je),this._element.classList.remove(Je),this._element.setAttribute("aria-expanded","false"),U.removeDataAttribute(this._menu,"popper"),j.trigger(this._element,"hidden.bs.dropdown",t))}_getConfig(t){if(t={...this.constructor.Default,...U.getDataAttributes(this._element),...t},a(Ue,t,this.constructor.DefaultType),"object"==typeof t.reference&&!o(t.reference)&&"function"!=typeof t.reference.getBoundingClientRect)throw new TypeError(`${Ue.toUpperCase()}: Option "reference" provided type "object" without a required "getBoundingClientRect" method.`);return t}_createPopper(t){if(void 0===Fe)throw new TypeError("Bootstrap's dropdowns require Popper (https://popper.js.org)");let e=this._element;"parent"===this._config.reference?e=t:o(this._config.reference)?e=r(this._config.reference):"object"==typeof this._config.reference&&(e=this._config.reference);const i=this._getPopperConfig(),n=i.modifiers.find((t=>"applyStyles"===t.name&&!1===t.enabled));this._popper=qe(e,this._menu,i),n&&U.setDataAttribute(this._menu,"popper","static")}_isShown(t=this._element){return t.classList.contains(Je)}_getMenuElement(){return V.next(this._element,ei)[0]}_getPlacement(){const t=this._element.parentNode;if(t.classList.contains("dropend"))return ri;if(t.classList.contains("dropstart"))return ai;const e="end"===getComputedStyle(this._menu).getPropertyValue("--bs-position").trim();return t.classList.contains("dropup")?e?ni:ii:e?oi:si}_detectNavbar(){return null!==this._element.closest(".navbar")}_getOffset(){const{offset:t}=this._config;return"string"==typeof t?t.split(",").map((t=>Number.parseInt(t,10))):"function"==typeof t?e=>t(e,this._element):t}_getPopperConfig(){const t={placement:this._getPlacement(),modifiers:[{name:"preventOverflow",options:{boundary:this._config.boundary}},{name:"offset",options:{offset:this._getOffset()}}]};return"static"===this._config.display&&(t.modifiers=[{name:"applyStyles",enabled:!1}]),{...t,..."function"==typeof this._config.popperConfig?this._config.popperConfig(t):this._config.popperConfig}}_selectMenuItem({key:t,target:e}){const i=V.find(".dropdown-menu .dropdown-item:not(.disabled):not(:disabled)",this._menu).filter(l);i.length&&v(i,e,t===Ye,!i.includes(e)).focus()}static jQueryInterface(t){return this.each((function(){const e=hi.getOrCreateInstance(this,t);if("string"==typeof t){if(void 0===e[t])throw new TypeError(`No method named "${t}"`);e[t]()}}))}static clearMenus(t){if(t&&(2===t.button||"keyup"===t.type&&"Tab"!==t.key))return;const e=V.find(ti);for(let i=0,n=e.length;i<n;i++){const n=hi.getInstance(e[i]);if(!n||!1===n._config.autoClose)continue;if(!n._isShown())continue;const s={relatedTarget:n._element};if(t){const e=t.composedPath(),i=e.includes(n._menu);if(e.includes(n._element)||"inside"===n._config.autoClose&&!i||"outside"===n._config.autoClose&&i)continue;if(n._menu.contains(t.target)&&("keyup"===t.type&&"Tab"===t.key||/input|select|option|textarea|form/i.test(t.target.tagName)))continue;"click"===t.type&&(s.clickEvent=t)}n._completeHide(s)}}static getParentFromElement(t){return n(t)||t.parentNode}static dataApiKeydownHandler(t){if(/input|textarea/i.test(t.target.tagName)?t.key===Ke||t.key!==Ve&&(t.key!==Ye&&t.key!==Xe||t.target.closest(ei)):!Qe.test(t.key))return;const e=this.classList.contains(Je);if(!e&&t.key===Ve)return;if(t.preventDefault(),t.stopPropagation(),c(this))return;const i=this.matches(ti)?this:V.prev(this,ti)[0],n=hi.getOrCreateInstance(i);if(t.key!==Ve)return t.key===Xe||t.key===Ye?(e||n.show(),void n._selectMenuItem(t)):void(e&&t.key!==Ke||hi.clearMenus());n.hide()}}j.on(document,Ze,ti,hi.dataApiKeydownHandler),j.on(document,Ze,ei,hi.dataApiKeydownHandler),j.on(document,Ge,hi.clearMenus),j.on(document,"keyup.bs.dropdown.data-api",hi.clearMenus),j.on(document,Ge,ti,(function(t){t.preventDefault(),hi.getOrCreateInstance(this).toggle()})),g(hi);const di=".fixed-top, .fixed-bottom, .is-fixed, .sticky-top",ui=".sticky-top";class fi{constructor(){this._element=document.body}getWidth(){const t=document.documentElement.clientWidth;return Math.abs(window.innerWidth-t)}hide(){const t=this.getWidth();this._disableOverFlow(),this._setElementAttributes(this._element,"paddingRight",(e=>e+t)),this._setElementAttributes(di,"paddingRight",(e=>e+t)),this._setElementAttributes(ui,"marginRight",(e=>e-t))}_disableOverFlow(){this._saveInitialAttribute(this._element,"overflow"),this._element.style.overflow="hidden"}_setElementAttributes(t,e,i){const n=this.getWidth();this._applyManipulationCallback(t,(t=>{if(t!==this._element&&window.innerWidth>t.clientWidth+n)return;this._saveInitialAttribute(t,e);const s=window.getComputedStyle(t)[e];t.style[e]=`${i(Number.parseFloat(s))}px`}))}reset(){this._resetElementAttributes(this._element,"overflow"),this._resetElementAttributes(this._element,"paddingRight"),this._resetElementAttributes(di,"paddingRight"),this._resetElementAttributes(ui,"marginRight")}_saveInitialAttribute(t,e){const i=t.style[e];i&&U.setDataAttribute(t,e,i)}_resetElementAttributes(t,e){this._applyManipulationCallback(t,(t=>{const i=U.getDataAttribute(t,e);void 0===i?t.style.removeProperty(e):(U.removeDataAttribute(t,e),t.style[e]=i)}))}_applyManipulationCallback(t,e){o(t)?e(t):V.find(t,this._element).forEach(e)}isOverflowing(){return this.getWidth()>0}}const pi={className:"modal-backdrop",isVisible:!0,isAnimated:!1,rootElement:"body",clickCallback:null},mi={className:"string",isVisible:"boolean",isAnimated:"boolean",rootElement:"(element|string)",clickCallback:"(function|null)"},gi="show",_i="mousedown.bs.backdrop";class bi{constructor(t){this._config=this._getConfig(t),this._isAppended=!1,this._element=null}show(t){this._config.isVisible?(this._append(),this._config.isAnimated&&u(this._getElement()),this._getElement().classList.add(gi),this._emulateAnimation((()=>{_(t)}))):_(t)}hide(t){this._config.isVisible?(this._getElement().classList.remove(gi),this._emulateAnimation((()=>{this.dispose(),_(t)}))):_(t)}_getElement(){if(!this._element){const t=document.createElement("div");t.className=this._config.className,this._config.isAnimated&&t.classList.add("fade"),this._element=t}return this._element}_getConfig(t){return(t={...pi,..."object"==typeof t?t:{}}).rootElement=r(t.rootElement),a("backdrop",t,mi),t}_append(){this._isAppended||(this._config.rootElement.append(this._getElement()),j.on(this._getElement(),_i,(()=>{_(this._config.clickCallback)})),this._isAppended=!0)}dispose(){this._isAppended&&(j.off(this._element,_i),this._element.remove(),this._isAppended=!1)}_emulateAnimation(t){b(t,this._getElement(),this._config.isAnimated)}}const vi={trapElement:null,autofocus:!0},yi={trapElement:"element",autofocus:"boolean"},wi=".bs.focustrap",Ei="backward";class Ai{constructor(t){this._config=this._getConfig(t),this._isActive=!1,this._lastTabNavDirection=null}activate(){const{trapElement:t,autofocus:e}=this._config;this._isActive||(e&&t.focus(),j.off(document,wi),j.on(document,"focusin.bs.focustrap",(t=>this._handleFocusin(t))),j.on(document,"keydown.tab.bs.focustrap",(t=>this._handleKeydown(t))),this._isActive=!0)}deactivate(){this._isActive&&(this._isActive=!1,j.off(document,wi))}_handleFocusin(t){const{target:e}=t,{trapElement:i}=this._config;if(e===document||e===i||i.contains(e))return;const n=V.focusableChildren(i);0===n.length?i.focus():this._lastTabNavDirection===Ei?n[n.length-1].focus():n[0].focus()}_handleKeydown(t){"Tab"===t.key&&(this._lastTabNavDirection=t.shiftKey?Ei:"forward")}_getConfig(t){return t={...vi,..."object"==typeof t?t:{}},a("focustrap",t,yi),t}}const Ti="modal",Oi="Escape",Ci={backdrop:!0,keyboard:!0,focus:!0},ki={backdrop:"(boolean|string)",keyboard:"boolean",focus:"boolean"},Li="hidden.bs.modal",xi="show.bs.modal",Di="resize.bs.modal",Si="click.dismiss.bs.modal",Ni="keydown.dismiss.bs.modal",Ii="mousedown.dismiss.bs.modal",Pi="modal-open",ji="show",Mi="modal-static";class Hi extends B{constructor(t,e){super(t),this._config=this._getConfig(e),this._dialog=V.findOne(".modal-dialog",this._element),this._backdrop=this._initializeBackDrop(),this._focustrap=this._initializeFocusTrap(),this._isShown=!1,this._ignoreBackdropClick=!1,this._isTransitioning=!1,this._scrollBar=new fi}static get Default(){return Ci}static get NAME(){return Ti}toggle(t){return this._isShown?this.hide():this.show(t)}show(t){this._isShown||this._isTransitioning||j.trigger(this._element,xi,{relatedTarget:t}).defaultPrevented||(this._isShown=!0,this._isAnimated()&&(this._isTransitioning=!0),this._scrollBar.hide(),document.body.classList.add(Pi),this._adjustDialog(),this._setEscapeEvent(),this._setResizeEvent(),j.on(this._dialog,Ii,(()=>{j.one(this._element,"mouseup.dismiss.bs.modal",(t=>{t.target===this._element&&(this._ignoreBackdropClick=!0)}))})),this._showBackdrop((()=>this._showElement(t))))}hide(){if(!this._isShown||this._isTransitioning)return;if(j.trigger(this._element,"hide.bs.modal").defaultPrevented)return;this._isShown=!1;const t=this._isAnimated();t&&(this._isTransitioning=!0),this._setEscapeEvent(),this._setResizeEvent(),this._focustrap.deactivate(),this._element.classList.remove(ji),j.off(this._element,Si),j.off(this._dialog,Ii),this._queueCallback((()=>this._hideModal()),this._element,t)}dispose(){[window,this._dialog].forEach((t=>j.off(t,".bs.modal"))),this._backdrop.dispose(),this._focustrap.deactivate(),super.dispose()}handleUpdate(){this._adjustDialog()}_initializeBackDrop(){return new bi({isVisible:Boolean(this._config.backdrop),isAnimated:this._isAnimated()})}_initializeFocusTrap(){return new Ai({trapElement:this._element})}_getConfig(t){return t={...Ci,...U.getDataAttributes(this._element),..."object"==typeof t?t:{}},a(Ti,t,ki),t}_showElement(t){const e=this._isAnimated(),i=V.findOne(".modal-body",this._dialog);this._element.parentNode&&this._element.parentNode.nodeType===Node.ELEMENT_NODE||document.body.append(this._element),this._element.style.display="block",this._element.removeAttribute("aria-hidden"),this._element.setAttribute("aria-modal",!0),this._element.setAttribute("role","dialog"),this._element.scrollTop=0,i&&(i.scrollTop=0),e&&u(this._element),this._element.classList.add(ji),this._queueCallback((()=>{this._config.focus&&this._focustrap.activate(),this._isTransitioning=!1,j.trigger(this._element,"shown.bs.modal",{relatedTarget:t})}),this._dialog,e)}_setEscapeEvent(){this._isShown?j.on(this._element,Ni,(t=>{this._config.keyboard&&t.key===Oi?(t.preventDefault(),this.hide()):this._config.keyboard||t.key!==Oi||this._triggerBackdropTransition()})):j.off(this._element,Ni)}_setResizeEvent(){this._isShown?j.on(window,Di,(()=>this._adjustDialog())):j.off(window,Di)}_hideModal(){this._element.style.display="none",this._element.setAttribute("aria-hidden",!0),this._element.removeAttribute("aria-modal"),this._element.removeAttribute("role"),this._isTransitioning=!1,this._backdrop.hide((()=>{document.body.classList.remove(Pi),this._resetAdjustments(),this._scrollBar.reset(),j.trigger(this._element,Li)}))}_showBackdrop(t){j.on(this._element,Si,(t=>{this._ignoreBackdropClick?this._ignoreBackdropClick=!1:t.target===t.currentTarget&&(!0===this._config.backdrop?this.hide():"static"===this._config.backdrop&&this._triggerBackdropTransition())})),this._backdrop.show(t)}_isAnimated(){return this._element.classList.contains("fade")}_triggerBackdropTransition(){if(j.trigger(this._element,"hidePrevented.bs.modal").defaultPrevented)return;const{classList:t,scrollHeight:e,style:i}=this._element,n=e>document.documentElement.clientHeight;!n&&"hidden"===i.overflowY||t.contains(Mi)||(n||(i.overflowY="hidden"),t.add(Mi),this._queueCallback((()=>{t.remove(Mi),n||this._queueCallback((()=>{i.overflowY=""}),this._dialog)}),this._dialog),this._element.focus())}_adjustDialog(){const t=this._element.scrollHeight>document.documentElement.clientHeight,e=this._scrollBar.getWidth(),i=e>0;(!i&&t&&!m()||i&&!t&&m())&&(this._element.style.paddingLeft=`${e}px`),(i&&!t&&!m()||!i&&t&&m())&&(this._element.style.paddingRight=`${e}px`)}_resetAdjustments(){this._element.style.paddingLeft="",this._element.style.paddingRight=""}static jQueryInterface(t,e){return this.each((function(){const i=Hi.getOrCreateInstance(this,t);if("string"==typeof t){if(void 0===i[t])throw new TypeError(`No method named "${t}"`);i[t](e)}}))}}j.on(document,"click.bs.modal.data-api",'[data-bs-toggle="modal"]',(function(t){const e=n(this);["A","AREA"].includes(this.tagName)&&t.preventDefault(),j.one(e,xi,(t=>{t.defaultPrevented||j.one(e,Li,(()=>{l(this)&&this.focus()}))}));const i=V.findOne(".modal.show");i&&Hi.getInstance(i).hide(),Hi.getOrCreateInstance(e).toggle(this)})),R(Hi),g(Hi);const Bi="offcanvas",Ri={backdrop:!0,keyboard:!0,scroll:!1},Wi={backdrop:"boolean",keyboard:"boolean",scroll:"boolean"},$i="show",zi=".offcanvas.show",qi="hidden.bs.offcanvas";class Fi extends B{constructor(t,e){super(t),this._config=this._getConfig(e),this._isShown=!1,this._backdrop=this._initializeBackDrop(),this._focustrap=this._initializeFocusTrap(),this._addEventListeners()}static get NAME(){return Bi}static get Default(){return Ri}toggle(t){return this._isShown?this.hide():this.show(t)}show(t){this._isShown||j.trigger(this._element,"show.bs.offcanvas",{relatedTarget:t}).defaultPrevented||(this._isShown=!0,this._element.style.visibility="visible",this._backdrop.show(),this._config.scroll||(new fi).hide(),this._element.removeAttribute("aria-hidden"),this._element.setAttribute("aria-modal",!0),this._element.setAttribute("role","dialog"),this._element.classList.add($i),this._queueCallback((()=>{this._config.scroll||this._focustrap.activate(),j.trigger(this._element,"shown.bs.offcanvas",{relatedTarget:t})}),this._element,!0))}hide(){this._isShown&&(j.trigger(this._element,"hide.bs.offcanvas").defaultPrevented||(this._focustrap.deactivate(),this._element.blur(),this._isShown=!1,this._element.classList.remove($i),this._backdrop.hide(),this._queueCallback((()=>{this._element.setAttribute("aria-hidden",!0),this._element.removeAttribute("aria-modal"),this._element.removeAttribute("role"),this._element.style.visibility="hidden",this._config.scroll||(new fi).reset(),j.trigger(this._element,qi)}),this._element,!0)))}dispose(){this._backdrop.dispose(),this._focustrap.deactivate(),super.dispose()}_getConfig(t){return t={...Ri,...U.getDataAttributes(this._element),..."object"==typeof t?t:{}},a(Bi,t,Wi),t}_initializeBackDrop(){return new bi({className:"offcanvas-backdrop",isVisible:this._config.backdrop,isAnimated:!0,rootElement:this._element.parentNode,clickCallback:()=>this.hide()})}_initializeFocusTrap(){return new Ai({trapElement:this._element})}_addEventListeners(){j.on(this._element,"keydown.dismiss.bs.offcanvas",(t=>{this._config.keyboard&&"Escape"===t.key&&this.hide()}))}static jQueryInterface(t){return this.each((function(){const e=Fi.getOrCreateInstance(this,t);if("string"==typeof t){if(void 0===e[t]||t.startsWith("_")||"constructor"===t)throw new TypeError(`No method named "${t}"`);e[t](this)}}))}}j.on(document,"click.bs.offcanvas.data-api",'[data-bs-toggle="offcanvas"]',(function(t){const e=n(this);if(["A","AREA"].includes(this.tagName)&&t.preventDefault(),c(this))return;j.one(e,qi,(()=>{l(this)&&this.focus()}));const i=V.findOne(zi);i&&i!==e&&Fi.getInstance(i).hide(),Fi.getOrCreateInstance(e).toggle(this)})),j.on(window,"load.bs.offcanvas.data-api",(()=>V.find(zi).forEach((t=>Fi.getOrCreateInstance(t).show())))),R(Fi),g(Fi);const Ui=new Set(["background","cite","href","itemtype","longdesc","poster","src","xlink:href"]),Vi=/^(?:(?:https?|mailto|ftp|tel|file|sms):|[^#&/:?]*(?:[#/?]|$))/i,Ki=/^data:(?:image\/(?:bmp|gif|jpeg|jpg|png|tiff|webp)|video\/(?:mpeg|mp4|ogg|webm)|audio\/(?:mp3|oga|ogg|opus));base64,[\d+/a-z]+=*$/i,Xi=(t,e)=>{const i=t.nodeName.toLowerCase();if(e.includes(i))return!Ui.has(i)||Boolean(Vi.test(t.nodeValue)||Ki.test(t.nodeValue));const n=e.filter((t=>t instanceof RegExp));for(let t=0,e=n.length;t<e;t++)if(n[t].test(i))return!0;return!1};function Yi(t,e,i){if(!t.length)return t;if(i&&"function"==typeof i)return i(t);const n=(new window.DOMParser).parseFromString(t,"text/html"),s=[].concat(...n.body.querySelectorAll("*"));for(let t=0,i=s.length;t<i;t++){const i=s[t],n=i.nodeName.toLowerCase();if(!Object.keys(e).includes(n)){i.remove();continue}const o=[].concat(...i.attributes),r=[].concat(e["*"]||[],e[n]||[]);o.forEach((t=>{Xi(t,r)||i.removeAttribute(t.nodeName)}))}return n.body.innerHTML}const Qi="tooltip",Gi=new Set(["sanitize","allowList","sanitizeFn"]),Zi={animation:"boolean",template:"string",title:"(string|element|function)",trigger:"string",delay:"(number|object)",html:"boolean",selector:"(string|boolean)",placement:"(string|function)",offset:"(array|string|function)",container:"(string|element|boolean)",fallbackPlacements:"array",boundary:"(string|element)",customClass:"(string|function)",sanitize:"boolean",sanitizeFn:"(null|function)",allowList:"object",popperConfig:"(null|object|function)"},Ji={AUTO:"auto",TOP:"top",RIGHT:m()?"left":"right",BOTTOM:"bottom",LEFT:m()?"right":"left"},tn={animation:!0,template:'<div class="tooltip" role="tooltip"><div class="tooltip-arrow"></div><div class="tooltip-inner"></div></div>',trigger:"hover focus",title:"",delay:0,html:!1,selector:!1,placement:"top",offset:[0,0],container:!1,fallbackPlacements:["top","right","bottom","left"],boundary:"clippingParents",customClass:"",sanitize:!0,sanitizeFn:null,allowList:{"*":["class","dir","id","lang","role",/^aria-[\w-]*$/i],a:["target","href","title","rel"],area:[],b:[],br:[],col:[],code:[],div:[],em:[],hr:[],h1:[],h2:[],h3:[],h4:[],h5:[],h6:[],i:[],img:["src","srcset","alt","title","width","height"],li:[],ol:[],p:[],pre:[],s:[],small:[],span:[],sub:[],sup:[],strong:[],u:[],ul:[]},popperConfig:null},en={HIDE:"hide.bs.tooltip",HIDDEN:"hidden.bs.tooltip",SHOW:"show.bs.tooltip",SHOWN:"shown.bs.tooltip",INSERTED:"inserted.bs.tooltip",CLICK:"click.bs.tooltip",FOCUSIN:"focusin.bs.tooltip",FOCUSOUT:"focusout.bs.tooltip",MOUSEENTER:"mouseenter.bs.tooltip",MOUSELEAVE:"mouseleave.bs.tooltip"},nn="fade",sn="show",on="show",rn="out",an=".tooltip-inner",ln=".modal",cn="hide.bs.modal",hn="hover",dn="focus";class un extends B{constructor(t,e){if(void 0===Fe)throw new TypeError("Bootstrap's tooltips require Popper (https://popper.js.org)");super(t),this._isEnabled=!0,this._timeout=0,this._hoverState="",this._activeTrigger={},this._popper=null,this._config=this._getConfig(e),this.tip=null,this._setListeners()}static get Default(){return tn}static get NAME(){return Qi}static get Event(){return en}static get DefaultType(){return Zi}enable(){this._isEnabled=!0}disable(){this._isEnabled=!1}toggleEnabled(){this._isEnabled=!this._isEnabled}toggle(t){if(this._isEnabled)if(t){const e=this._initializeOnDelegatedTarget(t);e._activeTrigger.click=!e._activeTrigger.click,e._isWithActiveTrigger()?e._enter(null,e):e._leave(null,e)}else{if(this.getTipElement().classList.contains(sn))return void this._leave(null,this);this._enter(null,this)}}dispose(){clearTimeout(this._timeout),j.off(this._element.closest(ln),cn,this._hideModalHandler),this.tip&&this.tip.remove(),this._disposePopper(),super.dispose()}show(){if("none"===this._element.style.display)throw new Error("Please use show on visible elements");if(!this.isWithContent()||!this._isEnabled)return;const t=j.trigger(this._element,this.constructor.Event.SHOW),e=h(this._element),i=null===e?this._element.ownerDocument.documentElement.contains(this._element):e.contains(this._element);if(t.defaultPrevented||!i)return;"tooltip"===this.constructor.NAME&&this.tip&&this.getTitle()!==this.tip.querySelector(an).innerHTML&&(this._disposePopper(),this.tip.remove(),this.tip=null);const n=this.getTipElement(),s=(t=>{do{t+=Math.floor(1e6*Math.random())}while(document.getElementById(t));return t})(this.constructor.NAME);n.setAttribute("id",s),this._element.setAttribute("aria-describedby",s),this._config.animation&&n.classList.add(nn);const o="function"==typeof this._config.placement?this._config.placement.call(this,n,this._element):this._config.placement,r=this._getAttachment(o);this._addAttachmentClass(r);const{container:a}=this._config;H.set(n,this.constructor.DATA_KEY,this),this._element.ownerDocument.documentElement.contains(this.tip)||(a.append(n),j.trigger(this._element,this.constructor.Event.INSERTED)),this._popper?this._popper.update():this._popper=qe(this._element,n,this._getPopperConfig(r)),n.classList.add(sn);const l=this._resolvePossibleFunction(this._config.customClass);l&&n.classList.add(...l.split(" ")),"ontouchstart"in document.documentElement&&[].concat(...document.body.children).forEach((t=>{j.on(t,"mouseover",d)}));const c=this.tip.classList.contains(nn);this._queueCallback((()=>{const t=this._hoverState;this._hoverState=null,j.trigger(this._element,this.constructor.Event.SHOWN),t===rn&&this._leave(null,this)}),this.tip,c)}hide(){if(!this._popper)return;const t=this.getTipElement();if(j.trigger(this._element,this.constructor.Event.HIDE).defaultPrevented)return;t.classList.remove(sn),"ontouchstart"in document.documentElement&&[].concat(...document.body.children).forEach((t=>j.off(t,"mouseover",d))),this._activeTrigger.click=!1,this._activeTrigger.focus=!1,this._activeTrigger.hover=!1;const e=this.tip.classList.contains(nn);this._queueCallback((()=>{this._isWithActiveTrigger()||(this._hoverState!==on&&t.remove(),this._cleanTipClass(),this._element.removeAttribute("aria-describedby"),j.trigger(this._element,this.constructor.Event.HIDDEN),this._disposePopper())}),this.tip,e),this._hoverState=""}update(){null!==this._popper&&this._popper.update()}isWithContent(){return Boolean(this.getTitle())}getTipElement(){if(this.tip)return this.tip;const t=document.createElement("div");t.innerHTML=this._config.template;const e=t.children[0];return this.setContent(e),e.classList.remove(nn,sn),this.tip=e,this.tip}setContent(t){this._sanitizeAndSetContent(t,this.getTitle(),an)}_sanitizeAndSetContent(t,e,i){const n=V.findOne(i,t);e||!n?this.setElementContent(n,e):n.remove()}setElementContent(t,e){if(null!==t)return o(e)?(e=r(e),void(this._config.html?e.parentNode!==t&&(t.innerHTML="",t.append(e)):t.textContent=e.textContent)):void(this._config.html?(this._config.sanitize&&(e=Yi(e,this._config.allowList,this._config.sanitizeFn)),t.innerHTML=e):t.textContent=e)}getTitle(){const t=this._element.getAttribute("data-bs-original-title")||this._config.title;return this._resolvePossibleFunction(t)}updateAttachment(t){return"right"===t?"end":"left"===t?"start":t}_initializeOnDelegatedTarget(t,e){return e||this.constructor.getOrCreateInstance(t.delegateTarget,this._getDelegateConfig())}_getOffset(){const{offset:t}=this._config;return"string"==typeof t?t.split(",").map((t=>Number.parseInt(t,10))):"function"==typeof t?e=>t(e,this._element):t}_resolvePossibleFunction(t){return"function"==typeof t?t.call(this._element):t}_getPopperConfig(t){const e={placement:t,modifiers:[{name:"flip",options:{fallbackPlacements:this._config.fallbackPlacements}},{name:"offset",options:{offset:this._getOffset()}},{name:"preventOverflow",options:{boundary:this._config.boundary}},{name:"arrow",options:{element:`.${this.constructor.NAME}-arrow`}},{name:"onChange",enabled:!0,phase:"afterWrite",fn:t=>this._handlePopperPlacementChange(t)}],onFirstUpdate:t=>{t.options.placement!==t.placement&&this._handlePopperPlacementChange(t)}};return{...e,..."function"==typeof this._config.popperConfig?this._config.popperConfig(e):this._config.popperConfig}}_addAttachmentClass(t){this.getTipElement().classList.add(`${this._getBasicClassPrefix()}-${this.updateAttachment(t)}`)}_getAttachment(t){return Ji[t.toUpperCase()]}_setListeners(){this._config.trigger.split(" ").forEach((t=>{if("click"===t)j.on(this._element,this.constructor.Event.CLICK,this._config.selector,(t=>this.toggle(t)));else if("manual"!==t){const e=t===hn?this.constructor.Event.MOUSEENTER:this.constructor.Event.FOCUSIN,i=t===hn?this.constructor.Event.MOUSELEAVE:this.constructor.Event.FOCUSOUT;j.on(this._element,e,this._config.selector,(t=>this._enter(t))),j.on(this._element,i,this._config.selector,(t=>this._leave(t)))}})),this._hideModalHandler=()=>{this._element&&this.hide()},j.on(this._element.closest(ln),cn,this._hideModalHandler),this._config.selector?this._config={...this._config,trigger:"manual",selector:""}:this._fixTitle()}_fixTitle(){const t=this._element.getAttribute("title"),e=typeof this._element.getAttribute("data-bs-original-title");(t||"string"!==e)&&(this._element.setAttribute("data-bs-original-title",t||""),!t||this._element.getAttribute("aria-label")||this._element.textContent||this._element.setAttribute("aria-label",t),this._element.setAttribute("title",""))}_enter(t,e){e=this._initializeOnDelegatedTarget(t,e),t&&(e._activeTrigger["focusin"===t.type?dn:hn]=!0),e.getTipElement().classList.contains(sn)||e._hoverState===on?e._hoverState=on:(clearTimeout(e._timeout),e._hoverState=on,e._config.delay&&e._config.delay.show?e._timeout=setTimeout((()=>{e._hoverState===on&&e.show()}),e._config.delay.show):e.show())}_leave(t,e){e=this._initializeOnDelegatedTarget(t,e),t&&(e._activeTrigger["focusout"===t.type?dn:hn]=e._element.contains(t.relatedTarget)),e._isWithActiveTrigger()||(clearTimeout(e._timeout),e._hoverState=rn,e._config.delay&&e._config.delay.hide?e._timeout=setTimeout((()=>{e._hoverState===rn&&e.hide()}),e._config.delay.hide):e.hide())}_isWithActiveTrigger(){for(const t in this._activeTrigger)if(this._activeTrigger[t])return!0;return!1}_getConfig(t){const e=U.getDataAttributes(this._element);return Object.keys(e).forEach((t=>{Gi.has(t)&&delete e[t]})),(t={...this.constructor.Default,...e,..."object"==typeof t&&t?t:{}}).container=!1===t.container?document.body:r(t.container),"number"==typeof t.delay&&(t.delay={show:t.delay,hide:t.delay}),"number"==typeof t.title&&(t.title=t.title.toString()),"number"==typeof t.content&&(t.content=t.content.toString()),a(Qi,t,this.constructor.DefaultType),t.sanitize&&(t.template=Yi(t.template,t.allowList,t.sanitizeFn)),t}_getDelegateConfig(){const t={};for(const e in this._config)this.constructor.Default[e]!==this._config[e]&&(t[e]=this._config[e]);return t}_cleanTipClass(){const t=this.getTipElement(),e=new RegExp(`(^|\\s)${this._getBasicClassPrefix()}\\S+`,"g"),i=t.getAttribute("class").match(e);null!==i&&i.length>0&&i.map((t=>t.trim())).forEach((e=>t.classList.remove(e)))}_getBasicClassPrefix(){return"bs-tooltip"}_handlePopperPlacementChange(t){const{state:e}=t;e&&(this.tip=e.elements.popper,this._cleanTipClass(),this._addAttachmentClass(this._getAttachment(e.placement)))}_disposePopper(){this._popper&&(this._popper.destroy(),this._popper=null)}static jQueryInterface(t){return this.each((function(){const e=un.getOrCreateInstance(this,t);if("string"==typeof t){if(void 0===e[t])throw new TypeError(`No method named "${t}"`);e[t]()}}))}}g(un);const fn={...un.Default,placement:"right",offset:[0,8],trigger:"click",content:"",template:'<div class="popover" role="tooltip"><div class="popover-arrow"></div><h3 class="popover-header"></h3><div class="popover-body"></div></div>'},pn={...un.DefaultType,content:"(string|element|function)"},mn={HIDE:"hide.bs.popover",HIDDEN:"hidden.bs.popover",SHOW:"show.bs.popover",SHOWN:"shown.bs.popover",INSERTED:"inserted.bs.popover",CLICK:"click.bs.popover",FOCUSIN:"focusin.bs.popover",FOCUSOUT:"focusout.bs.popover",MOUSEENTER:"mouseenter.bs.popover",MOUSELEAVE:"mouseleave.bs.popover"};class gn extends un{static get Default(){return fn}static get NAME(){return"popover"}static get Event(){return mn}static get DefaultType(){return pn}isWithContent(){return this.getTitle()||this._getContent()}setContent(t){this._sanitizeAndSetContent(t,this.getTitle(),".popover-header"),this._sanitizeAndSetContent(t,this._getContent(),".popover-body")}_getContent(){return this._resolvePossibleFunction(this._config.content)}_getBasicClassPrefix(){return"bs-popover"}static jQueryInterface(t){return this.each((function(){const e=gn.getOrCreateInstance(this,t);if("string"==typeof t){if(void 0===e[t])throw new TypeError(`No method named "${t}"`);e[t]()}}))}}g(gn);const _n="scrollspy",bn={offset:10,method:"auto",target:""},vn={offset:"number",method:"string",target:"(string|element)"},yn="active",wn=".nav-link, .list-group-item, .dropdown-item",En="position";class An extends B{constructor(t,e){super(t),this._scrollElement="BODY"===this._element.tagName?window:this._element,this._config=this._getConfig(e),this._offsets=[],this._targets=[],this._activeTarget=null,this._scrollHeight=0,j.on(this._scrollElement,"scroll.bs.scrollspy",(()=>this._process())),this.refresh(),this._process()}static get Default(){return bn}static get NAME(){return _n}refresh(){const t=this._scrollElement===this._scrollElement.window?"offset":En,e="auto"===this._config.method?t:this._config.method,n=e===En?this._getScrollTop():0;this._offsets=[],this._targets=[],this._scrollHeight=this._getScrollHeight(),V.find(wn,this._config.target).map((t=>{const s=i(t),o=s?V.findOne(s):null;if(o){const t=o.getBoundingClientRect();if(t.width||t.height)return[U[e](o).top+n,s]}return null})).filter((t=>t)).sort(((t,e)=>t[0]-e[0])).forEach((t=>{this._offsets.push(t[0]),this._targets.push(t[1])}))}dispose(){j.off(this._scrollElement,".bs.scrollspy"),super.dispose()}_getConfig(t){return(t={...bn,...U.getDataAttributes(this._element),..."object"==typeof t&&t?t:{}}).target=r(t.target)||document.documentElement,a(_n,t,vn),t}_getScrollTop(){return this._scrollElement===window?this._scrollElement.pageYOffset:this._scrollElement.scrollTop}_getScrollHeight(){return this._scrollElement.scrollHeight||Math.max(document.body.scrollHeight,document.documentElement.scrollHeight)}_getOffsetHeight(){return this._scrollElement===window?window.innerHeight:this._scrollElement.getBoundingClientRect().height}_process(){const t=this._getScrollTop()+this._config.offset,e=this._getScrollHeight(),i=this._config.offset+e-this._getOffsetHeight();if(this._scrollHeight!==e&&this.refresh(),t>=i){const t=this._targets[this._targets.length-1];this._activeTarget!==t&&this._activate(t)}else{if(this._activeTarget&&t<this._offsets[0]&&this._offsets[0]>0)return this._activeTarget=null,void this._clear();for(let e=this._offsets.length;e--;)this._activeTarget!==this._targets[e]&&t>=this._offsets[e]&&(void 0===this._offsets[e+1]||t<this._offsets[e+1])&&this._activate(this._targets[e])}}_activate(t){this._activeTarget=t,this._clear();const e=wn.split(",").map((e=>`${e}[data-bs-target="${t}"],${e}[href="${t}"]`)),i=V.findOne(e.join(","),this._config.target);i.classList.add(yn),i.classList.contains("dropdown-item")?V.findOne(".dropdown-toggle",i.closest(".dropdown")).classList.add(yn):V.parents(i,".nav, .list-group").forEach((t=>{V.prev(t,".nav-link, .list-group-item").forEach((t=>t.classList.add(yn))),V.prev(t,".nav-item").forEach((t=>{V.children(t,".nav-link").forEach((t=>t.classList.add(yn)))}))})),j.trigger(this._scrollElement,"activate.bs.scrollspy",{relatedTarget:t})}_clear(){V.find(wn,this._config.target).filter((t=>t.classList.contains(yn))).forEach((t=>t.classList.remove(yn)))}static jQueryInterface(t){return this.each((function(){const e=An.getOrCreateInstance(this,t);if("string"==typeof t){if(void 0===e[t])throw new TypeError(`No method named "${t}"`);e[t]()}}))}}j.on(window,"load.bs.scrollspy.data-api",(()=>{V.find('[data-bs-spy="scroll"]').forEach((t=>new An(t)))})),g(An);const Tn="active",On="fade",Cn="show",kn=".active",Ln=":scope > li > .active";class xn extends B{static get NAME(){return"tab"}show(){if(this._element.parentNode&&this._element.parentNode.nodeType===Node.ELEMENT_NODE&&this._element.classList.contains(Tn))return;let t;const e=n(this._element),i=this._element.closest(".nav, .list-group");if(i){const e="UL"===i.nodeName||"OL"===i.nodeName?Ln:kn;t=V.find(e,i),t=t[t.length-1]}const s=t?j.trigger(t,"hide.bs.tab",{relatedTarget:this._element}):null;if(j.trigger(this._element,"show.bs.tab",{relatedTarget:t}).defaultPrevented||null!==s&&s.defaultPrevented)return;this._activate(this._element,i);const o=()=>{j.trigger(t,"hidden.bs.tab",{relatedTarget:this._element}),j.trigger(this._element,"shown.bs.tab",{relatedTarget:t})};e?this._activate(e,e.parentNode,o):o()}_activate(t,e,i){const n=(!e||"UL"!==e.nodeName&&"OL"!==e.nodeName?V.children(e,kn):V.find(Ln,e))[0],s=i&&n&&n.classList.contains(On),o=()=>this._transitionComplete(t,n,i);n&&s?(n.classList.remove(Cn),this._queueCallback(o,t,!0)):o()}_transitionComplete(t,e,i){if(e){e.classList.remove(Tn);const t=V.findOne(":scope > .dropdown-menu .active",e.parentNode);t&&t.classList.remove(Tn),"tab"===e.getAttribute("role")&&e.setAttribute("aria-selected",!1)}t.classList.add(Tn),"tab"===t.getAttribute("role")&&t.setAttribute("aria-selected",!0),u(t),t.classList.contains(On)&&t.classList.add(Cn);let n=t.parentNode;if(n&&"LI"===n.nodeName&&(n=n.parentNode),n&&n.classList.contains("dropdown-menu")){const e=t.closest(".dropdown");e&&V.find(".dropdown-toggle",e).forEach((t=>t.classList.add(Tn))),t.setAttribute("aria-expanded",!0)}i&&i()}static jQueryInterface(t){return this.each((function(){const e=xn.getOrCreateInstance(this);if("string"==typeof t){if(void 0===e[t])throw new TypeError(`No method named "${t}"`);e[t]()}}))}}j.on(document,"click.bs.tab.data-api",'[data-bs-toggle="tab"], [data-bs-toggle="pill"], [data-bs-toggle="list"]',(function(t){["A","AREA"].includes(this.tagName)&&t.preventDefault(),c(this)||xn.getOrCreateInstance(this).show()})),g(xn);const Dn="toast",Sn="hide",Nn="show",In="showing",Pn={animation:"boolean",autohide:"boolean",delay:"number"},jn={animation:!0,autohide:!0,delay:5e3};class Mn extends B{constructor(t,e){super(t),this._config=this._getConfig(e),this._timeout=null,this._hasMouseInteraction=!1,this._hasKeyboardInteraction=!1,this._setListeners()}static get DefaultType(){return Pn}static get Default(){return jn}static get NAME(){return Dn}show(){j.trigger(this._element,"show.bs.toast").defaultPrevented||(this._clearTimeout(),this._config.animation&&this._element.classList.add("fade"),this._element.classList.remove(Sn),u(this._element),this._element.classList.add(Nn),this._element.classList.add(In),this._queueCallback((()=>{this._element.classList.remove(In),j.trigger(this._element,"shown.bs.toast"),this._maybeScheduleHide()}),this._element,this._config.animation))}hide(){this._element.classList.contains(Nn)&&(j.trigger(this._element,"hide.bs.toast").defaultPrevented||(this._element.classList.add(In),this._queueCallback((()=>{this._element.classList.add(Sn),this._element.classList.remove(In),this._element.classList.remove(Nn),j.trigger(this._element,"hidden.bs.toast")}),this._element,this._config.animation)))}dispose(){this._clearTimeout(),this._element.classList.contains(Nn)&&this._element.classList.remove(Nn),super.dispose()}_getConfig(t){return t={...jn,...U.getDataAttributes(this._element),..."object"==typeof t&&t?t:{}},a(Dn,t,this.constructor.DefaultType),t}_maybeScheduleHide(){this._config.autohide&&(this._hasMouseInteraction||this._hasKeyboardInteraction||(this._timeout=setTimeout((()=>{this.hide()}),this._config.delay)))}_onInteraction(t,e){switch(t.type){case"mouseover":case"mouseout":this._hasMouseInteraction=e;break;case"focusin":case"focusout":this._hasKeyboardInteraction=e}if(e)return void this._clearTimeout();const i=t.relatedTarget;this._element===i||this._element.contains(i)||this._maybeScheduleHide()}_setListeners(){j.on(this._element,"mouseover.bs.toast",(t=>this._onInteraction(t,!0))),j.on(this._element,"mouseout.bs.toast",(t=>this._onInteraction(t,!1))),j.on(this._element,"focusin.bs.toast",(t=>this._onInteraction(t,!0))),j.on(this._element,"focusout.bs.toast",(t=>this._onInteraction(t,!1)))}_clearTimeout(){clearTimeout(this._timeout),this._timeout=null}static jQueryInterface(t){return this.each((function(){const e=Mn.getOrCreateInstance(this,t);if("string"==typeof t){if(void 0===e[t])throw new TypeError(`No method named "${t}"`);e[t](this)}}))}}return R(Mn),g(Mn),{Alert:W,Button:z,Carousel:st,Collapse:pt,Dropdown:hi,Modal:Hi,Offcanvas:Fi,Popover:gn,ScrollSpy:An,Tab:xn,Toast:Mn,Tooltip:un}}));
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m?m(Object.assign({},e.rects,{placement:e.placement})):m,O="number"==typeof C?{mainAxis:C,altAxis:C}:Object.assign({mainAxis:0,altAxis:0},C),x=e.modifiersData.offset?e.modifiersData.offset[e.placement]:null,k={x:0,y:0};if(A){if(o){var L,S="y"===y?zt:Vt,D="y"===y?Rt:qt,$="y"===y?"height":"width",I=A[y],N=I+g[S],P=I-g[D],M=f?-T[$]/2:0,j=b===Xt?E[$]:T[$],F=b===Xt?-T[$]:-E[$],H=e.elements.arrow,W=f&&H?Ce(H):{width:0,height:0},B=e.modifiersData["arrow#persistent"]?e.modifiersData["arrow#persistent"].padding:{top:0,right:0,bottom:0,left:0},z=B[S],R=B[D],q=Ne(0,E[$],W[$]),V=v?E[$]/2-M-q-z-O.mainAxis:j-q-z-O.mainAxis,K=v?-E[$]/2+M+q+R+O.mainAxis:F+q+R+O.mainAxis,Q=e.elements.arrow&&$e(e.elements.arrow),X=Q?"y"===y?Q.clientTop||0:Q.clientLeft||0:0,Y=null!=(L=null==x?void 0:x[y])?L:0,U=I+K-Y,G=Ne(f?ye(N,I+V-Y-X):N,I,f?ve(P,U):P);A[y]=G,k[y]=G-I}if(a){var J,Z="x"===y?zt:Vt,tt="x"===y?Rt:qt,et=A[w],it="y"===w?"height":"width",nt=et+g[Z],st=et-g[tt],ot=-1!==[zt,Vt].indexOf(_),rt=null!=(J=null==x?void 0:x[w])?J:0,at=ot?nt:et-E[it]-T[it]-rt+O.altAxis,lt=ot?et+E[it]+T[it]-rt-O.altAxis:st,ct=f&&ot?function(t,e,i){var n=Ne(t,e,i);return n>i?i:n}(at,et,lt):Ne(f?at:nt,et,f?lt:st);A[w]=ct,k[w]=ct-et}e.modifiersData[n]=k}},requiresIfExists:["offset"]};function di(t,e,i){void 0===i&&(i=!1);var n,s,o=me(e),r=me(e)&&function(t){var e=t.getBoundingClientRect(),i=we(e.width)/t.offsetWidth||1,n=we(e.height)/t.offsetHeight||1;return 1!==i||1!==n}(e),a=Le(e),l=Te(t,r,i),c={scrollLeft:0,scrollTop:0},h={x:0,y:0};return(o||!o&&!i)&&(("body"!==ue(e)||Ue(a))&&(c=(n=e)!==fe(n)&&me(n)?{scrollLeft:(s=n).scrollLeft,scrollTop:s.scrollTop}:Xe(n)),me(e)?((h=Te(e,!0)).x+=e.clientLeft,h.y+=e.clientTop):a&&(h.x=Ye(a))),{x:l.left+c.scrollLeft-h.x,y:l.top+c.scrollTop-h.y,width:l.width,height:l.height}}function ui(t){var e=new Map,i=new Set,n=[];function s(t){i.add(t.name),[].concat(t.requires||[],t.requiresIfExists||[]).forEach((function(t){if(!i.has(t)){var n=e.get(t);n&&s(n)}})),n.push(t)}return t.forEach((function(t){e.set(t.name,t)})),t.forEach((function(t){i.has(t.name)||s(t)})),n}var fi={placement:"bottom",modifiers:[],strategy:"absolute"};function pi(){for(var t=arguments.length,e=new Array(t),i=0;i<t;i++)e[i]=arguments[i];return!e.some((function(t){return!(t&&"function"==typeof t.getBoundingClientRect)}))}function mi(t){void 0===t&&(t={});var e=t,i=e.defaultModifiers,n=void 0===i?[]:i,s=e.defaultOptions,o=void 0===s?fi:s;return function(t,e,i){void 0===i&&(i=o);var s,r,a={placement:"bottom",orderedModifiers:[],options:Object.assign({},fi,o),modifiersData:{},elements:{reference:t,popper:e},attributes:{},styles:{}},l=[],c=!1,h={state:a,setOptions:function(i){var s="function"==typeof i?i(a.options):i;d(),a.options=Object.assign({},o,a.options,s),a.scrollParents={reference:pe(t)?Je(t):t.contextElement?Je(t.contextElement):[],popper:Je(e)};var r,c,u=function(t){var e=ui(t);return de.reduce((function(t,i){return t.concat(e.filter((function(t){return t.phase===i})))}),[])}((r=[].concat(n,a.options.modifiers),c=r.reduce((function(t,e){var i=t[e.name];return t[e.name]=i?Object.assign({},i,e,{options:Object.assign({},i.options,e.options),data:Object.assign({},i.data,e.data)}):e,t}),{}),Object.keys(c).map((function(t){return c[t]}))));return a.orderedModifiers=u.filter((function(t){return t.enabled})),a.orderedModifiers.forEach((function(t){var e=t.name,i=t.options,n=void 0===i?{}:i,s=t.effect;if("function"==typeof s){var o=s({state:a,name:e,instance:h,options:n});l.push(o||function(){})}})),h.update()},forceUpdate:function(){if(!c){var t=a.elements,e=t.reference,i=t.popper;if(pi(e,i)){a.rects={reference:di(e,$e(i),"fixed"===a.options.strategy),popper:Ce(i)},a.reset=!1,a.placement=a.options.placement,a.orderedModifiers.forEach((function(t){return a.modifiersData[t.name]=Object.assign({},t.data)}));for(var n=0;n<a.orderedModifiers.length;n++)if(!0!==a.reset){var s=a.orderedModifiers[n],o=s.fn,r=s.options,l=void 0===r?{}:r,d=s.name;"function"==typeof o&&(a=o({state:a,options:l,name:d,instance:h})||a)}else a.reset=!1,n=-1}}},update:(s=function(){return new Promise((function(t){h.forceUpdate(),t(a)}))},function(){return r||(r=new Promise((function(t){Promise.resolve().then((function(){r=void 0,t(s())}))}))),r}),destroy:function(){d(),c=!0}};if(!pi(t,e))return h;function d(){l.forEach((function(t){return t()})),l=[]}return h.setOptions(i).then((function(t){!c&&i.onFirstUpdate&&i.onFirstUpdate(t)})),h}}var gi=mi(),_i=mi({defaultModifiers:[Re,ci,Be,_e]}),bi=mi({defaultModifiers:[Re,ci,Be,_e,li,si,hi,je,ai]});const vi=Object.freeze(Object.defineProperty({__proto__:null,afterMain:ae,afterRead:se,afterWrite:he,applyStyles:_e,arrow:je,auto:Kt,basePlacements:Qt,beforeMain:oe,beforeRead:ie,beforeWrite:le,bottom:Rt,clippingParents:Ut,computeStyles:Be,createPopper:bi,createPopperBase:gi,createPopperLite:_i,detectOverflow:ii,end:Yt,eventListeners:Re,flip:si,hide:ai,left:Vt,main:re,modifierPhases:de,offset:li,placements:ee,popper:Jt,popperGenerator:mi,popperOffsets:ci,preventOverflow:hi,read:ne,reference:Zt,right:qt,start:Xt,top:zt,variationPlacements:te,viewport:Gt,write:ce},Symbol.toStringTag,{value:"Module"})),yi="dropdown",wi=".bs.dropdown",Ai=".data-api",Ei="ArrowUp",Ti="ArrowDown",Ci=`hide${wi}`,Oi=`hidden${wi}`,xi=`show${wi}`,ki=`shown${wi}`,Li=`click${wi}${Ai}`,Si=`keydown${wi}${Ai}`,Di=`keyup${wi}${Ai}`,$i="show",Ii='[data-bs-toggle="dropdown"]:not(.disabled):not(:disabled)',Ni=`${Ii}.${$i}`,Pi=".dropdown-menu",Mi=p()?"top-end":"top-start",ji=p()?"top-start":"top-end",Fi=p()?"bottom-end":"bottom-start",Hi=p()?"bottom-start":"bottom-end",Wi=p()?"left-start":"right-start",Bi=p()?"right-start":"left-start",zi={autoClose:!0,boundary:"clippingParents",display:"dynamic",offset:[0,2],popperConfig:null,reference:"toggle"},Ri={autoClose:"(boolean|string)",boundary:"(string|element)",display:"string",offset:"(array|string|function)",popperConfig:"(null|object|function)",reference:"(string|element|object)"};class qi extends W{constructor(t,e){super(t,e),this._popper=null,this._parent=this._element.parentNode,this._menu=z.next(this._element,Pi)[0]||z.prev(this._element,Pi)[0]||z.findOne(Pi,this._parent),this._inNavbar=this._detectNavbar()}static get Default(){return zi}static get DefaultType(){return Ri}static get NAME(){return yi}toggle(){return this._isShown()?this.hide():this.show()}show(){if(l(this._element)||this._isShown())return;const t={relatedTarget:this._element};if(!N.trigger(this._element,xi,t).defaultPrevented){if(this._createPopper(),"ontouchstart"in document.documentElement&&!this._parent.closest(".navbar-nav"))for(const t of[].concat(...document.body.children))N.on(t,"mouseover",h);this._element.focus(),this._element.setAttribute("aria-expanded",!0),this._menu.classList.add($i),this._element.classList.add($i),N.trigger(this._element,ki,t)}}hide(){if(l(this._element)||!this._isShown())return;const t={relatedTarget:this._element};this._completeHide(t)}dispose(){this._popper&&this._popper.destroy(),super.dispose()}update(){this._inNavbar=this._detectNavbar(),this._popper&&this._popper.update()}_completeHide(t){if(!N.trigger(this._element,Ci,t).defaultPrevented){if("ontouchstart"in document.documentElement)for(const t of[].concat(...document.body.children))N.off(t,"mouseover",h);this._popper&&this._popper.destroy(),this._menu.classList.remove($i),this._element.classList.remove($i),this._element.setAttribute("aria-expanded","false"),F.removeDataAttribute(this._menu,"popper"),N.trigger(this._element,Oi,t)}}_getConfig(t){if("object"==typeof(t=super._getConfig(t)).reference&&!o(t.reference)&&"function"!=typeof t.reference.getBoundingClientRect)throw new TypeError(`${yi.toUpperCase()}: Option "reference" provided type "object" without a required "getBoundingClientRect" method.`);return t}_createPopper(){if(void 0===vi)throw new TypeError("Bootstrap's dropdowns require Popper (https://popper.js.org)");let t=this._element;"parent"===this._config.reference?t=this._parent:o(this._config.reference)?t=r(this._config.reference):"object"==typeof this._config.reference&&(t=this._config.reference);const e=this._getPopperConfig();this._popper=bi(t,this._menu,e)}_isShown(){return this._menu.classList.contains($i)}_getPlacement(){const t=this._parent;if(t.classList.contains("dropend"))return Wi;if(t.classList.contains("dropstart"))return Bi;if(t.classList.contains("dropup-center"))return"top";if(t.classList.contains("dropdown-center"))return"bottom";const e="end"===getComputedStyle(this._menu).getPropertyValue("--bs-position").trim();return t.classList.contains("dropup")?e?ji:Mi:e?Hi:Fi}_detectNavbar(){return null!==this._element.closest(".navbar")}_getOffset(){const{offset:t}=this._config;return"string"==typeof t?t.split(",").map((t=>Number.parseInt(t,10))):"function"==typeof t?e=>t(e,this._element):t}_getPopperConfig(){const t={placement:this._getPlacement(),modifiers:[{name:"preventOverflow",options:{boundary:this._config.boundary}},{name:"offset",options:{offset:this._getOffset()}}]};return(this._inNavbar||"static"===this._config.display)&&(F.setDataAttribute(this._menu,"popper","static"),t.modifiers=[{name:"applyStyles",enabled:!1}]),{...t,...g(this._config.popperConfig,[t])}}_selectMenuItem({key:t,target:e}){const i=z.find(".dropdown-menu .dropdown-item:not(.disabled):not(:disabled)",this._menu).filter((t=>a(t)));i.length&&b(i,e,t===Ti,!i.includes(e)).focus()}static jQueryInterface(t){return this.each((function(){const e=qi.getOrCreateInstance(this,t);if("string"==typeof t){if(void 0===e[t])throw new TypeError(`No method named "${t}"`);e[t]()}}))}static clearMenus(t){if(2===t.button||"keyup"===t.type&&"Tab"!==t.key)return;const e=z.find(Ni);for(const i of e){const e=qi.getInstance(i);if(!e||!1===e._config.autoClose)continue;const n=t.composedPath(),s=n.includes(e._menu);if(n.includes(e._element)||"inside"===e._config.autoClose&&!s||"outside"===e._config.autoClose&&s)continue;if(e._menu.contains(t.target)&&("keyup"===t.type&&"Tab"===t.key||/input|select|option|textarea|form/i.test(t.target.tagName)))continue;const o={relatedTarget:e._element};"click"===t.type&&(o.clickEvent=t),e._completeHide(o)}}static dataApiKeydownHandler(t){const e=/input|textarea/i.test(t.target.tagName),i="Escape"===t.key,n=[Ei,Ti].includes(t.key);if(!n&&!i)return;if(e&&!i)return;t.preventDefault();const s=this.matches(Ii)?this:z.prev(this,Ii)[0]||z.next(this,Ii)[0]||z.findOne(Ii,t.delegateTarget.parentNode),o=qi.getOrCreateInstance(s);if(n)return t.stopPropagation(),o.show(),void o._selectMenuItem(t);o._isShown()&&(t.stopPropagation(),o.hide(),s.focus())}}N.on(document,Si,Ii,qi.dataApiKeydownHandler),N.on(document,Si,Pi,qi.dataApiKeydownHandler),N.on(document,Li,qi.clearMenus),N.on(document,Di,qi.clearMenus),N.on(document,Li,Ii,(function(t){t.preventDefault(),qi.getOrCreateInstance(this).toggle()})),m(qi);const Vi="backdrop",Ki="show",Qi=`mousedown.bs.${Vi}`,Xi={className:"modal-backdrop",clickCallback:null,isAnimated:!1,isVisible:!0,rootElement:"body"},Yi={className:"string",clickCallback:"(function|null)",isAnimated:"boolean",isVisible:"boolean",rootElement:"(element|string)"};class Ui extends H{constructor(t){super(),this._config=this._getConfig(t),this._isAppended=!1,this._element=null}static get Default(){return Xi}static get DefaultType(){return Yi}static get NAME(){return Vi}show(t){if(!this._config.isVisible)return void g(t);this._append();const e=this._getElement();this._config.isAnimated&&d(e),e.classList.add(Ki),this._emulateAnimation((()=>{g(t)}))}hide(t){this._config.isVisible?(this._getElement().classList.remove(Ki),this._emulateAnimation((()=>{this.dispose(),g(t)}))):g(t)}dispose(){this._isAppended&&(N.off(this._element,Qi),this._element.remove(),this._isAppended=!1)}_getElement(){if(!this._element){const t=document.createElement("div");t.className=this._config.className,this._config.isAnimated&&t.classList.add("fade"),this._element=t}return this._element}_configAfterMerge(t){return t.rootElement=r(t.rootElement),t}_append(){if(this._isAppended)return;const t=this._getElement();this._config.rootElement.append(t),N.on(t,Qi,(()=>{g(this._config.clickCallback)})),this._isAppended=!0}_emulateAnimation(t){_(t,this._getElement(),this._config.isAnimated)}}const Gi=".bs.focustrap",Ji=`focusin${Gi}`,Zi=`keydown.tab${Gi}`,tn="backward",en={autofocus:!0,trapElement:null},nn={autofocus:"boolean",trapElement:"element"};class sn extends H{constructor(t){super(),this._config=this._getConfig(t),this._isActive=!1,this._lastTabNavDirection=null}static get Default(){return en}static get DefaultType(){return nn}static get NAME(){return"focustrap"}activate(){this._isActive||(this._config.autofocus&&this._config.trapElement.focus(),N.off(document,Gi),N.on(document,Ji,(t=>this._handleFocusin(t))),N.on(document,Zi,(t=>this._handleKeydown(t))),this._isActive=!0)}deactivate(){this._isActive&&(this._isActive=!1,N.off(document,Gi))}_handleFocusin(t){const{trapElement:e}=this._config;if(t.target===document||t.target===e||e.contains(t.target))return;const i=z.focusableChildren(e);0===i.length?e.focus():this._lastTabNavDirection===tn?i[i.length-1].focus():i[0].focus()}_handleKeydown(t){"Tab"===t.key&&(this._lastTabNavDirection=t.shiftKey?tn:"forward")}}const on=".fixed-top, .fixed-bottom, .is-fixed, .sticky-top",rn=".sticky-top",an="padding-right",ln="margin-right";class cn{constructor(){this._element=document.body}getWidth(){const t=document.documentElement.clientWidth;return Math.abs(window.innerWidth-t)}hide(){const t=this.getWidth();this._disableOverFlow(),this._setElementAttributes(this._element,an,(e=>e+t)),this._setElementAttributes(on,an,(e=>e+t)),this._setElementAttributes(rn,ln,(e=>e-t))}reset(){this._resetElementAttributes(this._element,"overflow"),this._resetElementAttributes(this._element,an),this._resetElementAttributes(on,an),this._resetElementAttributes(rn,ln)}isOverflowing(){return this.getWidth()>0}_disableOverFlow(){this._saveInitialAttribute(this._element,"overflow"),this._element.style.overflow="hidden"}_setElementAttributes(t,e,i){const n=this.getWidth();this._applyManipulationCallback(t,(t=>{if(t!==this._element&&window.innerWidth>t.clientWidth+n)return;this._saveInitialAttribute(t,e);const s=window.getComputedStyle(t).getPropertyValue(e);t.style.setProperty(e,`${i(Number.parseFloat(s))}px`)}))}_saveInitialAttribute(t,e){const i=t.style.getPropertyValue(e);i&&F.setDataAttribute(t,e,i)}_resetElementAttributes(t,e){this._applyManipulationCallback(t,(t=>{const i=F.getDataAttribute(t,e);null!==i?(F.removeDataAttribute(t,e),t.style.setProperty(e,i)):t.style.removeProperty(e)}))}_applyManipulationCallback(t,e){if(o(t))e(t);else for(const i of z.find(t,this._element))e(i)}}const hn=".bs.modal",dn=`hide${hn}`,un=`hidePrevented${hn}`,fn=`hidden${hn}`,pn=`show${hn}`,mn=`shown${hn}`,gn=`resize${hn}`,_n=`click.dismiss${hn}`,bn=`mousedown.dismiss${hn}`,vn=`keydown.dismiss${hn}`,yn=`click${hn}.data-api`,wn="modal-open",An="show",En="modal-static",Tn={backdrop:!0,focus:!0,keyboard:!0},Cn={backdrop:"(boolean|string)",focus:"boolean",keyboard:"boolean"};class On extends W{constructor(t,e){super(t,e),this._dialog=z.findOne(".modal-dialog",this._element),this._backdrop=this._initializeBackDrop(),this._focustrap=this._initializeFocusTrap(),this._isShown=!1,this._isTransitioning=!1,this._scrollBar=new cn,this._addEventListeners()}static get Default(){return Tn}static get DefaultType(){return Cn}static get NAME(){return"modal"}toggle(t){return this._isShown?this.hide():this.show(t)}show(t){this._isShown||this._isTransitioning||N.trigger(this._element,pn,{relatedTarget:t}).defaultPrevented||(this._isShown=!0,this._isTransitioning=!0,this._scrollBar.hide(),document.body.classList.add(wn),this._adjustDialog(),this._backdrop.show((()=>this._showElement(t))))}hide(){this._isShown&&!this._isTransitioning&&(N.trigger(this._element,dn).defaultPrevented||(this._isShown=!1,this._isTransitioning=!0,this._focustrap.deactivate(),this._element.classList.remove(An),this._queueCallback((()=>this._hideModal()),this._element,this._isAnimated())))}dispose(){N.off(window,hn),N.off(this._dialog,hn),this._backdrop.dispose(),this._focustrap.deactivate(),super.dispose()}handleUpdate(){this._adjustDialog()}_initializeBackDrop(){return new Ui({isVisible:Boolean(this._config.backdrop),isAnimated:this._isAnimated()})}_initializeFocusTrap(){return new sn({trapElement:this._element})}_showElement(t){document.body.contains(this._element)||document.body.append(this._element),this._element.style.display="block",this._element.removeAttribute("aria-hidden"),this._element.setAttribute("aria-modal",!0),this._element.setAttribute("role","dialog"),this._element.scrollTop=0;const e=z.findOne(".modal-body",this._dialog);e&&(e.scrollTop=0),d(this._element),this._element.classList.add(An),this._queueCallback((()=>{this._config.focus&&this._focustrap.activate(),this._isTransitioning=!1,N.trigger(this._element,mn,{relatedTarget:t})}),this._dialog,this._isAnimated())}_addEventListeners(){N.on(this._element,vn,(t=>{"Escape"===t.key&&(this._config.keyboard?this.hide():this._triggerBackdropTransition())})),N.on(window,gn,(()=>{this._isShown&&!this._isTransitioning&&this._adjustDialog()})),N.on(this._element,bn,(t=>{N.one(this._element,_n,(e=>{this._element===t.target&&this._element===e.target&&("static"!==this._config.backdrop?this._config.backdrop&&this.hide():this._triggerBackdropTransition())}))}))}_hideModal(){this._element.style.display="none",this._element.setAttribute("aria-hidden",!0),this._element.removeAttribute("aria-modal"),this._element.removeAttribute("role"),this._isTransitioning=!1,this._backdrop.hide((()=>{document.body.classList.remove(wn),this._resetAdjustments(),this._scrollBar.reset(),N.trigger(this._element,fn)}))}_isAnimated(){return this._element.classList.contains("fade")}_triggerBackdropTransition(){if(N.trigger(this._element,un).defaultPrevented)return;const t=this._element.scrollHeight>document.documentElement.clientHeight,e=this._element.style.overflowY;"hidden"===e||this._element.classList.contains(En)||(t||(this._element.style.overflowY="hidden"),this._element.classList.add(En),this._queueCallback((()=>{this._element.classList.remove(En),this._queueCallback((()=>{this._element.style.overflowY=e}),this._dialog)}),this._dialog),this._element.focus())}_adjustDialog(){const t=this._element.scrollHeight>document.documentElement.clientHeight,e=this._scrollBar.getWidth(),i=e>0;if(i&&!t){const t=p()?"paddingLeft":"paddingRight";this._element.style[t]=`${e}px`}if(!i&&t){const t=p()?"paddingRight":"paddingLeft";this._element.style[t]=`${e}px`}}_resetAdjustments(){this._element.style.paddingLeft="",this._element.style.paddingRight=""}static jQueryInterface(t,e){return this.each((function(){const i=On.getOrCreateInstance(this,t);if("string"==typeof t){if(void 0===i[t])throw new TypeError(`No method named "${t}"`);i[t](e)}}))}}N.on(document,yn,'[data-bs-toggle="modal"]',(function(t){const e=z.getElementFromSelector(this);["A","AREA"].includes(this.tagName)&&t.preventDefault(),N.one(e,pn,(t=>{t.defaultPrevented||N.one(e,fn,(()=>{a(this)&&this.focus()}))}));const i=z.findOne(".modal.show");i&&On.getInstance(i).hide(),On.getOrCreateInstance(e).toggle(this)})),R(On),m(On);const xn=".bs.offcanvas",kn=".data-api",Ln=`load${xn}${kn}`,Sn="show",Dn="showing",$n="hiding",In=".offcanvas.show",Nn=`show${xn}`,Pn=`shown${xn}`,Mn=`hide${xn}`,jn=`hidePrevented${xn}`,Fn=`hidden${xn}`,Hn=`resize${xn}`,Wn=`click${xn}${kn}`,Bn=`keydown.dismiss${xn}`,zn={backdrop:!0,keyboard:!0,scroll:!1},Rn={backdrop:"(boolean|string)",keyboard:"boolean",scroll:"boolean"};class qn extends W{constructor(t,e){super(t,e),this._isShown=!1,this._backdrop=this._initializeBackDrop(),this._focustrap=this._initializeFocusTrap(),this._addEventListeners()}static get Default(){return zn}static get DefaultType(){return Rn}static get NAME(){return"offcanvas"}toggle(t){return this._isShown?this.hide():this.show(t)}show(t){this._isShown||N.trigger(this._element,Nn,{relatedTarget:t}).defaultPrevented||(this._isShown=!0,this._backdrop.show(),this._config.scroll||(new cn).hide(),this._element.setAttribute("aria-modal",!0),this._element.setAttribute("role","dialog"),this._element.classList.add(Dn),this._queueCallback((()=>{this._config.scroll&&!this._config.backdrop||this._focustrap.activate(),this._element.classList.add(Sn),this._element.classList.remove(Dn),N.trigger(this._element,Pn,{relatedTarget:t})}),this._element,!0))}hide(){this._isShown&&(N.trigger(this._element,Mn).defaultPrevented||(this._focustrap.deactivate(),this._element.blur(),this._isShown=!1,this._element.classList.add($n),this._backdrop.hide(),this._queueCallback((()=>{this._element.classList.remove(Sn,$n),this._element.removeAttribute("aria-modal"),this._element.removeAttribute("role"),this._config.scroll||(new cn).reset(),N.trigger(this._element,Fn)}),this._element,!0)))}dispose(){this._backdrop.dispose(),this._focustrap.deactivate(),super.dispose()}_initializeBackDrop(){const t=Boolean(this._config.backdrop);return new Ui({className:"offcanvas-backdrop",isVisible:t,isAnimated:!0,rootElement:this._element.parentNode,clickCallback:t?()=>{"static"!==this._config.backdrop?this.hide():N.trigger(this._element,jn)}:null})}_initializeFocusTrap(){return new sn({trapElement:this._element})}_addEventListeners(){N.on(this._element,Bn,(t=>{"Escape"===t.key&&(this._config.keyboard?this.hide():N.trigger(this._element,jn))}))}static jQueryInterface(t){return this.each((function(){const e=qn.getOrCreateInstance(this,t);if("string"==typeof t){if(void 0===e[t]||t.startsWith("_")||"constructor"===t)throw new TypeError(`No method named "${t}"`);e[t](this)}}))}}N.on(document,Wn,'[data-bs-toggle="offcanvas"]',(function(t){const e=z.getElementFromSelector(this);if(["A","AREA"].includes(this.tagName)&&t.preventDefault(),l(this))return;N.one(e,Fn,(()=>{a(this)&&this.focus()}));const i=z.findOne(In);i&&i!==e&&qn.getInstance(i).hide(),qn.getOrCreateInstance(e).toggle(this)})),N.on(window,Ln,(()=>{for(const t of z.find(In))qn.getOrCreateInstance(t).show()})),N.on(window,Hn,(()=>{for(const t of z.find("[aria-modal][class*=show][class*=offcanvas-]"))"fixed"!==getComputedStyle(t).position&&qn.getOrCreateInstance(t).hide()})),R(qn),m(qn);const Vn={"*":["class","dir","id","lang","role",/^aria-[\w-]*$/i],a:["target","href","title","rel"],area:[],b:[],br:[],col:[],code:[],div:[],em:[],hr:[],h1:[],h2:[],h3:[],h4:[],h5:[],h6:[],i:[],img:["src","srcset","alt","title","width","height"],li:[],ol:[],p:[],pre:[],s:[],small:[],span:[],sub:[],sup:[],strong:[],u:[],ul:[]},Kn=new Set(["background","cite","href","itemtype","longdesc","poster","src","xlink:href"]),Qn=/^(?!javascript:)(?:[a-z0-9+.-]+:|[^&:/?#]*(?:[/?#]|$))/i,Xn=(t,e)=>{const i=t.nodeName.toLowerCase();return e.includes(i)?!Kn.has(i)||Boolean(Qn.test(t.nodeValue)):e.filter((t=>t instanceof RegExp)).some((t=>t.test(i)))},Yn={allowList:Vn,content:{},extraClass:"",html:!1,sanitize:!0,sanitizeFn:null,template:"<div></div>"},Un={allowList:"object",content:"object",extraClass:"(string|function)",html:"boolean",sanitize:"boolean",sanitizeFn:"(null|function)",template:"string"},Gn={entry:"(string|element|function|null)",selector:"(string|element)"};class Jn extends H{constructor(t){super(),this._config=this._getConfig(t)}static get Default(){return Yn}static get DefaultType(){return Un}static get NAME(){return"TemplateFactory"}getContent(){return Object.values(this._config.content).map((t=>this._resolvePossibleFunction(t))).filter(Boolean)}hasContent(){return this.getContent().length>0}changeContent(t){return this._checkContent(t),this._config.content={...this._config.content,...t},this}toHtml(){const t=document.createElement("div");t.innerHTML=this._maybeSanitize(this._config.template);for(const[e,i]of Object.entries(this._config.content))this._setContent(t,i,e);const e=t.children[0],i=this._resolvePossibleFunction(this._config.extraClass);return i&&e.classList.add(...i.split(" ")),e}_typeCheckConfig(t){super._typeCheckConfig(t),this._checkContent(t.content)}_checkContent(t){for(const[e,i]of Object.entries(t))super._typeCheckConfig({selector:e,entry:i},Gn)}_setContent(t,e,i){const n=z.findOne(i,t);n&&((e=this._resolvePossibleFunction(e))?o(e)?this._putElementInTemplate(r(e),n):this._config.html?n.innerHTML=this._maybeSanitize(e):n.textContent=e:n.remove())}_maybeSanitize(t){return this._config.sanitize?function(t,e,i){if(!t.length)return t;if(i&&"function"==typeof i)return i(t);const n=(new window.DOMParser).parseFromString(t,"text/html"),s=[].concat(...n.body.querySelectorAll("*"));for(const t of s){const i=t.nodeName.toLowerCase();if(!Object.keys(e).includes(i)){t.remove();continue}const n=[].concat(...t.attributes),s=[].concat(e["*"]||[],e[i]||[]);for(const e of n)Xn(e,s)||t.removeAttribute(e.nodeName)}return n.body.innerHTML}(t,this._config.allowList,this._config.sanitizeFn):t}_resolvePossibleFunction(t){return g(t,[this])}_putElementInTemplate(t,e){if(this._config.html)return e.innerHTML="",void e.append(t);e.textContent=t.textContent}}const Zn=new Set(["sanitize","allowList","sanitizeFn"]),ts="fade",es="show",is=".modal",ns="hide.bs.modal",ss="hover",os="focus",rs={AUTO:"auto",TOP:"top",RIGHT:p()?"left":"right",BOTTOM:"bottom",LEFT:p()?"right":"left"},as={allowList:Vn,animation:!0,boundary:"clippingParents",container:!1,customClass:"",delay:0,fallbackPlacements:["top","right","bottom","left"],html:!1,offset:[0,6],placement:"top",popperConfig:null,sanitize:!0,sanitizeFn:null,selector:!1,template:'<div class="tooltip" role="tooltip"><div class="tooltip-arrow"></div><div class="tooltip-inner"></div></div>',title:"",trigger:"hover focus"},ls={allowList:"object",animation:"boolean",boundary:"(string|element)",container:"(string|element|boolean)",customClass:"(string|function)",delay:"(number|object)",fallbackPlacements:"array",html:"boolean",offset:"(array|string|function)",placement:"(string|function)",popperConfig:"(null|object|function)",sanitize:"boolean",sanitizeFn:"(null|function)",selector:"(string|boolean)",template:"string",title:"(string|element|function)",trigger:"string"};class cs extends W{constructor(t,e){if(void 0===vi)throw new TypeError("Bootstrap's tooltips require Popper (https://popper.js.org)");super(t,e),this._isEnabled=!0,this._timeout=0,this._isHovered=null,this._activeTrigger={},this._popper=null,this._templateFactory=null,this._newContent=null,this.tip=null,this._setListeners(),this._config.selector||this._fixTitle()}static get Default(){return as}static get DefaultType(){return ls}static get NAME(){return"tooltip"}enable(){this._isEnabled=!0}disable(){this._isEnabled=!1}toggleEnabled(){this._isEnabled=!this._isEnabled}toggle(){this._isEnabled&&(this._activeTrigger.click=!this._activeTrigger.click,this._isShown()?this._leave():this._enter())}dispose(){clearTimeout(this._timeout),N.off(this._element.closest(is),ns,this._hideModalHandler),this._element.getAttribute("data-bs-original-title")&&this._element.setAttribute("title",this._element.getAttribute("data-bs-original-title")),this._disposePopper(),super.dispose()}show(){if("none"===this._element.style.display)throw new Error("Please use show on visible elements");if(!this._isWithContent()||!this._isEnabled)return;const t=N.trigger(this._element,this.constructor.eventName("show")),e=(c(this._element)||this._element.ownerDocument.documentElement).contains(this._element);if(t.defaultPrevented||!e)return;this._disposePopper();const i=this._getTipElement();this._element.setAttribute("aria-describedby",i.getAttribute("id"));const{container:n}=this._config;if(this._element.ownerDocument.documentElement.contains(this.tip)||(n.append(i),N.trigger(this._element,this.constructor.eventName("inserted"))),this._popper=this._createPopper(i),i.classList.add(es),"ontouchstart"in document.documentElement)for(const t of[].concat(...document.body.children))N.on(t,"mouseover",h);this._queueCallback((()=>{N.trigger(this._element,this.constructor.eventName("shown")),!1===this._isHovered&&this._leave(),this._isHovered=!1}),this.tip,this._isAnimated())}hide(){if(this._isShown()&&!N.trigger(this._element,this.constructor.eventName("hide")).defaultPrevented){if(this._getTipElement().classList.remove(es),"ontouchstart"in document.documentElement)for(const t of[].concat(...document.body.children))N.off(t,"mouseover",h);this._activeTrigger.click=!1,this._activeTrigger[os]=!1,this._activeTrigger[ss]=!1,this._isHovered=null,this._queueCallback((()=>{this._isWithActiveTrigger()||(this._isHovered||this._disposePopper(),this._element.removeAttribute("aria-describedby"),N.trigger(this._element,this.constructor.eventName("hidden")))}),this.tip,this._isAnimated())}}update(){this._popper&&this._popper.update()}_isWithContent(){return Boolean(this._getTitle())}_getTipElement(){return this.tip||(this.tip=this._createTipElement(this._newContent||this._getContentForTemplate())),this.tip}_createTipElement(t){const e=this._getTemplateFactory(t).toHtml();if(!e)return null;e.classList.remove(ts,es),e.classList.add(`bs-${this.constructor.NAME}-auto`);const i=(t=>{do{t+=Math.floor(1e6*Math.random())}while(document.getElementById(t));return t})(this.constructor.NAME).toString();return e.setAttribute("id",i),this._isAnimated()&&e.classList.add(ts),e}setContent(t){this._newContent=t,this._isShown()&&(this._disposePopper(),this.show())}_getTemplateFactory(t){return this._templateFactory?this._templateFactory.changeContent(t):this._templateFactory=new Jn({...this._config,content:t,extraClass:this._resolvePossibleFunction(this._config.customClass)}),this._templateFactory}_getContentForTemplate(){return{".tooltip-inner":this._getTitle()}}_getTitle(){return this._resolvePossibleFunction(this._config.title)||this._element.getAttribute("data-bs-original-title")}_initializeOnDelegatedTarget(t){return this.constructor.getOrCreateInstance(t.delegateTarget,this._getDelegateConfig())}_isAnimated(){return this._config.animation||this.tip&&this.tip.classList.contains(ts)}_isShown(){return this.tip&&this.tip.classList.contains(es)}_createPopper(t){const e=g(this._config.placement,[this,t,this._element]),i=rs[e.toUpperCase()];return bi(this._element,t,this._getPopperConfig(i))}_getOffset(){const{offset:t}=this._config;return"string"==typeof t?t.split(",").map((t=>Number.parseInt(t,10))):"function"==typeof t?e=>t(e,this._element):t}_resolvePossibleFunction(t){return g(t,[this._element])}_getPopperConfig(t){const e={placement:t,modifiers:[{name:"flip",options:{fallbackPlacements:this._config.fallbackPlacements}},{name:"offset",options:{offset:this._getOffset()}},{name:"preventOverflow",options:{boundary:this._config.boundary}},{name:"arrow",options:{element:`.${this.constructor.NAME}-arrow`}},{name:"preSetPlacement",enabled:!0,phase:"beforeMain",fn:t=>{this._getTipElement().setAttribute("data-popper-placement",t.state.placement)}}]};return{...e,...g(this._config.popperConfig,[e])}}_setListeners(){const t=this._config.trigger.split(" ");for(const e of t)if("click"===e)N.on(this._element,this.constructor.eventName("click"),this._config.selector,(t=>{this._initializeOnDelegatedTarget(t).toggle()}));else if("manual"!==e){const t=e===ss?this.constructor.eventName("mouseenter"):this.constructor.eventName("focusin"),i=e===ss?this.constructor.eventName("mouseleave"):this.constructor.eventName("focusout");N.on(this._element,t,this._config.selector,(t=>{const e=this._initializeOnDelegatedTarget(t);e._activeTrigger["focusin"===t.type?os:ss]=!0,e._enter()})),N.on(this._element,i,this._config.selector,(t=>{const e=this._initializeOnDelegatedTarget(t);e._activeTrigger["focusout"===t.type?os:ss]=e._element.contains(t.relatedTarget),e._leave()}))}this._hideModalHandler=()=>{this._element&&this.hide()},N.on(this._element.closest(is),ns,this._hideModalHandler)}_fixTitle(){const t=this._element.getAttribute("title");t&&(this._element.getAttribute("aria-label")||this._element.textContent.trim()||this._element.setAttribute("aria-label",t),this._element.setAttribute("data-bs-original-title",t),this._element.removeAttribute("title"))}_enter(){this._isShown()||this._isHovered?this._isHovered=!0:(this._isHovered=!0,this._setTimeout((()=>{this._isHovered&&this.show()}),this._config.delay.show))}_leave(){this._isWithActiveTrigger()||(this._isHovered=!1,this._setTimeout((()=>{this._isHovered||this.hide()}),this._config.delay.hide))}_setTimeout(t,e){clearTimeout(this._timeout),this._timeout=setTimeout(t,e)}_isWithActiveTrigger(){return Object.values(this._activeTrigger).includes(!0)}_getConfig(t){const e=F.getDataAttributes(this._element);for(const t of Object.keys(e))Zn.has(t)&&delete e[t];return t={...e,..."object"==typeof t&&t?t:{}},t=this._mergeConfigObj(t),t=this._configAfterMerge(t),this._typeCheckConfig(t),t}_configAfterMerge(t){return t.container=!1===t.container?document.body:r(t.container),"number"==typeof t.delay&&(t.delay={show:t.delay,hide:t.delay}),"number"==typeof t.title&&(t.title=t.title.toString()),"number"==typeof t.content&&(t.content=t.content.toString()),t}_getDelegateConfig(){const t={};for(const[e,i]of Object.entries(this._config))this.constructor.Default[e]!==i&&(t[e]=i);return t.selector=!1,t.trigger="manual",t}_disposePopper(){this._popper&&(this._popper.destroy(),this._popper=null),this.tip&&(this.tip.remove(),this.tip=null)}static jQueryInterface(t){return this.each((function(){const e=cs.getOrCreateInstance(this,t);if("string"==typeof t){if(void 0===e[t])throw new TypeError(`No method named "${t}"`);e[t]()}}))}}m(cs);const hs={...cs.Default,content:"",offset:[0,8],placement:"right",template:'<div class="popover" role="tooltip"><div class="popover-arrow"></div><h3 class="popover-header"></h3><div class="popover-body"></div></div>',trigger:"click"},ds={...cs.DefaultType,content:"(null|string|element|function)"};class us extends cs{static get Default(){return hs}static get DefaultType(){return ds}static get NAME(){return"popover"}_isWithContent(){return this._getTitle()||this._getContent()}_getContentForTemplate(){return{".popover-header":this._getTitle(),".popover-body":this._getContent()}}_getContent(){return this._resolvePossibleFunction(this._config.content)}static jQueryInterface(t){return this.each((function(){const e=us.getOrCreateInstance(this,t);if("string"==typeof t){if(void 0===e[t])throw new TypeError(`No method named "${t}"`);e[t]()}}))}}m(us);const fs=".bs.scrollspy",ps=`activate${fs}`,ms=`click${fs}`,gs=`load${fs}.data-api`,_s="active",bs="[href]",vs=".nav-link",ys=`${vs}, .nav-item > ${vs}, .list-group-item`,ws={offset:null,rootMargin:"0px 0px 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t){if(!o.isIntersecting){this._activeTarget=null,this._clearActiveClass(e(o));continue}const t=o.target.offsetTop>=this._previousScrollData.visibleEntryTop;if(s&&t){if(i(o),!n)return}else s||t||i(o)}}_initializeTargetsAndObservables(){this._targetLinks=new Map,this._observableSections=new Map;const t=z.find(bs,this._config.target);for(const e of t){if(!e.hash||l(e))continue;const t=z.findOne(decodeURI(e.hash),this._element);a(t)&&(this._targetLinks.set(decodeURI(e.hash),e),this._observableSections.set(e.hash,t))}}_process(t){this._activeTarget!==t&&(this._clearActiveClass(this._config.target),this._activeTarget=t,t.classList.add(_s),this._activateParents(t),N.trigger(this._element,ps,{relatedTarget:t}))}_activateParents(t){if(t.classList.contains("dropdown-item"))z.findOne(".dropdown-toggle",t.closest(".dropdown")).classList.add(_s);else for(const e of z.parents(t,".nav, .list-group"))for(const t of z.prev(e,ys))t.classList.add(_s)}_clearActiveClass(t){t.classList.remove(_s);const e=z.find(`${bs}.${_s}`,t);for(const t of e)t.classList.remove(_s)}static jQueryInterface(t){return this.each((function(){const e=Es.getOrCreateInstance(this,t);if("string"==typeof t){if(void 0===e[t]||t.startsWith("_")||"constructor"===t)throw new TypeError(`No method named "${t}"`);e[t]()}}))}}N.on(window,gs,(()=>{for(const t of z.find('[data-bs-spy="scroll"]'))Es.getOrCreateInstance(t)})),m(Es);const Ts=".bs.tab",Cs=`hide${Ts}`,Os=`hidden${Ts}`,xs=`show${Ts}`,ks=`shown${Ts}`,Ls=`click${Ts}`,Ss=`keydown${Ts}`,Ds=`load${Ts}`,$s="ArrowLeft",Is="ArrowRight",Ns="ArrowUp",Ps="ArrowDown",Ms="Home",js="End",Fs="active",Hs="fade",Ws="show",Bs=":not(.dropdown-toggle)",zs='[data-bs-toggle="tab"], [data-bs-toggle="pill"], [data-bs-toggle="list"]',Rs=`.nav-link${Bs}, .list-group-item${Bs}, [role="tab"]${Bs}, ${zs}`,qs=`.${Fs}[data-bs-toggle="tab"], .${Fs}[data-bs-toggle="pill"], .${Fs}[data-bs-toggle="list"]`;class Vs extends W{constructor(t){super(t),this._parent=this._element.closest('.list-group, .nav, [role="tablist"]'),this._parent&&(this._setInitialAttributes(this._parent,this._getChildren()),N.on(this._element,Ss,(t=>this._keydown(t))))}static get NAME(){return"tab"}show(){const t=this._element;if(this._elemIsActive(t))return;const e=this._getActiveElem(),i=e?N.trigger(e,Cs,{relatedTarget:t}):null;N.trigger(t,xs,{relatedTarget:e}).defaultPrevented||i&&i.defaultPrevented||(this._deactivate(e,t),this._activate(t,e))}_activate(t,e){t&&(t.classList.add(Fs),this._activate(z.getElementFromSelector(t)),this._queueCallback((()=>{"tab"===t.getAttribute("role")?(t.removeAttribute("tabindex"),t.setAttribute("aria-selected",!0),this._toggleDropDown(t,!0),N.trigger(t,ks,{relatedTarget:e})):t.classList.add(Ws)}),t,t.classList.contains(Hs)))}_deactivate(t,e){t&&(t.classList.remove(Fs),t.blur(),this._deactivate(z.getElementFromSelector(t)),this._queueCallback((()=>{"tab"===t.getAttribute("role")?(t.setAttribute("aria-selected",!1),t.setAttribute("tabindex","-1"),this._toggleDropDown(t,!1),N.trigger(t,Os,{relatedTarget:e})):t.classList.remove(Ws)}),t,t.classList.contains(Hs)))}_keydown(t){if(![$s,Is,Ns,Ps,Ms,js].includes(t.key))return;t.stopPropagation(),t.preventDefault();const e=this._getChildren().filter((t=>!l(t)));let 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diff --git a/docs/site_libs/clipboard/clipboard.min.js b/docs/site_libs/clipboard/clipboard.min.js
index 41c6a0f..1103f81 100644
--- a/docs/site_libs/clipboard/clipboard.min.js
+++ b/docs/site_libs/clipboard/clipboard.min.js
@@ -1,7 +1,7 @@
 /*!
- * clipboard.js v2.0.10
+ * clipboard.js v2.0.11
  * https://clipboardjs.com/
  *
  * Licensed MIT © Zeno Rocha
  */
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e,n="SELECT"===t.nodeName?(t.focus(),t.value):"INPUT"===t.nodeName||"TEXTAREA"===t.nodeName?((e=t.hasAttribute("readonly"))||t.setAttribute("readonly",""),t.select(),t.setSelectionRange(0,t.value.length),e||t.removeAttribute("readonly"),t.value):(t.hasAttribute("contenteditable")&&t.focus(),n=window.getSelection(),(e=document.createRange()).selectNodeContents(t),n.removeAllRanges(),n.addRange(e),n.toString());return n}},279:function(t){function e(){}e.prototype={on:function(t,e,n){var o=this.e||(this.e={});return(o[t]||(o[t]=[])).push({fn:e,ctx:n}),this},once:function(t,e,n){var o=this;function r(){o.off(t,r),e.apply(n,arguments)}return r._=e,this.on(t,r,n)},emit:function(t){for(var e=[].slice.call(arguments,1),n=((this.e||(this.e={}))[t]||[]).slice(),o=0,r=n.length;o<r;o++)n[o].fn.apply(n[o].ctx,e);return this},off:function(t,e){var n=this.e||(this.e={}),o=n[t],r=[];if(o&&e)for(var i=0,u=o.length;i<u;i++)o[i].fn!==e&&o[i].fn._!==e&&r.push(o[i]);return r.length?n[t]=r:delete n[t],this}},t.exports=e,t.exports.TinyEmitter=e}},r={},o.n=function(t){var e=t&&t.__esModule?function(){return t.default}:function(){return t};return o.d(e,{a:e}),e},o.d=function(t,e){for(var n in e)o.o(e,n)&&!o.o(t,n)&&Object.defineProperty(t,n,{enumerable:!0,get:e[n]})},o.o=function(t,e){return Object.prototype.hasOwnProperty.call(t,e)},o(686).default;function o(t){if(r[t])return r[t].exports;var e=r[t]={exports:{}};return n[t](e,e.exports,o),e.exports}var n,r});
\ No newline at end of file
diff --git a/docs/site_libs/quarto-html/anchor.min.js b/docs/site_libs/quarto-html/anchor.min.js
index 1c2b86f..5ac814d 100644
--- a/docs/site_libs/quarto-html/anchor.min.js
+++ b/docs/site_libs/quarto-html/anchor.min.js
@@ -1,9 +1,9 @@
 // @license magnet:?xt=urn:btih:d3d9a9a6595521f9666a5e94cc830dab83b65699&dn=expat.txt Expat
 //
-// AnchorJS - v4.3.1 - 2021-04-17
+// AnchorJS - v5.0.0 - 2023-01-18
 // https://www.bryanbraun.com/anchorjs/
-// Copyright (c) 2021 Bryan Braun; Licensed MIT
+// Copyright (c) 2023 Bryan Braun; Licensed MIT
 //
 // @license magnet:?xt=urn:btih:d3d9a9a6595521f9666a5e94cc830dab83b65699&dn=expat.txt Expat
-!function(A,e){"use strict";"function"==typeof define&&define.amd?define([],e):"object"==typeof module&&module.exports?module.exports=e():(A.AnchorJS=e(),A.anchors=new A.AnchorJS)}(this,function(){"use strict";return function(A){function d(A){A.icon=Object.prototype.hasOwnProperty.call(A,"icon")?A.icon:"",A.visible=Object.prototype.hasOwnProperty.call(A,"visible")?A.visible:"hover",A.placement=Object.prototype.hasOwnProperty.call(A,"placement")?A.placement:"right",A.ariaLabel=Object.prototype.hasOwnProperty.call(A,"ariaLabel")?A.ariaLabel:"Anchor",A.class=Object.prototype.hasOwnProperty.call(A,"class")?A.class:"",A.base=Object.prototype.hasOwnProperty.call(A,"base")?A.base:"",A.truncate=Object.prototype.hasOwnProperty.call(A,"truncate")?Math.floor(A.truncate):64,A.titleText=Object.prototype.hasOwnProperty.call(A,"titleText")?A.titleText:""}function w(A){var e;if("string"==typeof A||A instanceof String)e=[].slice.call(document.querySelectorAll(A));else{if(!(Array.isArray(A)||A instanceof NodeList))throw new TypeError("The selector provided to AnchorJS was invalid.");e=[].slice.call(A)}return e}this.options=A||{},this.elements=[],d(this.options),this.isTouchDevice=function(){return Boolean("ontouchstart"in window||window.TouchEvent||window.DocumentTouch&&document instanceof DocumentTouch)},this.add=function(A){var e,t,o,i,n,s,a,c,r,l,h,u,p=[];if(d(this.options),"touch"===(l=this.options.visible)&&(l=this.isTouchDevice()?"always":"hover"),0===(e=w(A=A||"h2, h3, h4, h5, h6")).length)return this;for(null===document.head.querySelector("style.anchorjs")&&((u=document.createElement("style")).className="anchorjs",u.appendChild(document.createTextNode("")),void 0===(A=document.head.querySelector('[rel="stylesheet"],style'))?document.head.appendChild(u):document.head.insertBefore(u,A),u.sheet.insertRule(".anchorjs-link{opacity:0;text-decoration:none;-webkit-font-smoothing:antialiased;-moz-osx-font-smoothing:grayscale}",u.sheet.cssRules.length),u.sheet.insertRule(":hover>.anchorjs-link,.anchorjs-link:focus{opacity:1}",u.sheet.cssRules.length),u.sheet.insertRule("[data-anchorjs-icon]::after{content:attr(data-anchorjs-icon)}",u.sheet.cssRules.length),u.sheet.insertRule('@font-face{font-family:anchorjs-icons;src:url(data:n/a;base64,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) format("truetype")}',u.sheet.cssRules.length)),u=document.querySelectorAll("[id]"),t=[].map.call(u,function(A){return A.id}),i=0;i<e.length;i++)if(this.hasAnchorJSLink(e[i]))p.push(i);else{if(e[i].hasAttribute("id"))o=e[i].getAttribute("id");else if(e[i].hasAttribute("data-anchor-id"))o=e[i].getAttribute("data-anchor-id");else{for(c=a=this.urlify(e[i].textContent),s=0;n=t.indexOf(c=void 0!==n?a+"-"+s:c),s+=1,-1!==n;);n=void 0,t.push(c),e[i].setAttribute("id",c),o=c}(r=document.createElement("a")).className="anchorjs-link "+this.options.class,r.setAttribute("aria-label",this.options.ariaLabel),r.setAttribute("data-anchorjs-icon",this.options.icon),this.options.titleText&&(r.title=this.options.titleText),h=document.querySelector("base")?window.location.pathname+window.location.search:"",h=this.options.base||h,r.href=h+"#"+o,"always"===l&&(r.style.opacity="1"),""===this.options.icon&&(r.style.font="1em/1 anchorjs-icons","left"===this.options.placement&&(r.style.lineHeight="inherit")),"left"===this.options.placement?(r.style.position="absolute",r.style.marginLeft="-1em",r.style.paddingRight=".5em",e[i].insertBefore(r,e[i].firstChild)):(r.style.paddingLeft=".375em",e[i].appendChild(r))}for(i=0;i<p.length;i++)e.splice(p[i]-i,1);return this.elements=this.elements.concat(e),this},this.remove=function(A){for(var e,t,o=w(A),i=0;i<o.length;i++)(t=o[i].querySelector(".anchorjs-link"))&&(-1!==(e=this.elements.indexOf(o[i]))&&this.elements.splice(e,1),o[i].removeChild(t));return this},this.removeAll=function(){this.remove(this.elements)},this.urlify=function(A){var e=document.createElement("textarea");return e.innerHTML=A,A=e.value,this.options.truncate||d(this.options),A.trim().replace(/'/gi,"").replace(/[& +$,:;=?@"#{}|^~[`%!'<>\]./()*\\\n\t\b\v\u00A0]/g,"-").replace(/-{2,}/g,"-").substring(0,this.options.truncate).replace(/^-+|-+$/gm,"").toLowerCase()},this.hasAnchorJSLink=function(A){var e=A.firstChild&&-1<(" "+A.firstChild.className+" ").indexOf(" anchorjs-link "),A=A.lastChild&&-1<(" "+A.lastChild.className+" ").indexOf(" anchorjs-link ");return e||A||!1}}});
+!function(A,e){"use strict";"function"==typeof define&&define.amd?define([],e):"object"==typeof module&&module.exports?module.exports=e():(A.AnchorJS=e(),A.anchors=new A.AnchorJS)}(globalThis,function(){"use strict";return function(A){function u(A){A.icon=Object.prototype.hasOwnProperty.call(A,"icon")?A.icon:"",A.visible=Object.prototype.hasOwnProperty.call(A,"visible")?A.visible:"hover",A.placement=Object.prototype.hasOwnProperty.call(A,"placement")?A.placement:"right",A.ariaLabel=Object.prototype.hasOwnProperty.call(A,"ariaLabel")?A.ariaLabel:"Anchor",A.class=Object.prototype.hasOwnProperty.call(A,"class")?A.class:"",A.base=Object.prototype.hasOwnProperty.call(A,"base")?A.base:"",A.truncate=Object.prototype.hasOwnProperty.call(A,"truncate")?Math.floor(A.truncate):64,A.titleText=Object.prototype.hasOwnProperty.call(A,"titleText")?A.titleText:""}function d(A){var e;if("string"==typeof A||A instanceof String)e=[].slice.call(document.querySelectorAll(A));else{if(!(Array.isArray(A)||A instanceof NodeList))throw new TypeError("The selector provided to AnchorJS was invalid.");e=[].slice.call(A)}return e}this.options=A||{},this.elements=[],u(this.options),this.add=function(A){var e,t,o,i,n,s,a,r,l,c,h,p=[];if(u(this.options),0!==(e=d(A=A||"h2, h3, h4, h5, h6")).length){for(null===document.head.querySelector("style.anchorjs")&&((A=document.createElement("style")).className="anchorjs",A.appendChild(document.createTextNode("")),void 0===(h=document.head.querySelector('[rel="stylesheet"],style'))?document.head.appendChild(A):document.head.insertBefore(A,h),A.sheet.insertRule(".anchorjs-link{opacity:0;text-decoration:none;-webkit-font-smoothing:antialiased;-moz-osx-font-smoothing:grayscale}",A.sheet.cssRules.length),A.sheet.insertRule(":hover>.anchorjs-link,.anchorjs-link:focus{opacity:1}",A.sheet.cssRules.length),A.sheet.insertRule("[data-anchorjs-icon]::after{content:attr(data-anchorjs-icon)}",A.sheet.cssRules.length),A.sheet.insertRule('@font-face{font-family:anchorjs-icons;src:url(data:n/a;base64,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) format("truetype")}',A.sheet.cssRules.length)),h=document.querySelectorAll("[id]"),t=[].map.call(h,function(A){return A.id}),i=0;i<e.length;i++)if(this.hasAnchorJSLink(e[i]))p.push(i);else{if(e[i].hasAttribute("id"))o=e[i].getAttribute("id");else if(e[i].hasAttribute("data-anchor-id"))o=e[i].getAttribute("data-anchor-id");else{for(r=a=this.urlify(e[i].textContent),s=0;n=t.indexOf(r=void 0!==n?a+"-"+s:r),s+=1,-1!==n;);n=void 0,t.push(r),e[i].setAttribute("id",r),o=r}(l=document.createElement("a")).className="anchorjs-link "+this.options.class,l.setAttribute("aria-label",this.options.ariaLabel),l.setAttribute("data-anchorjs-icon",this.options.icon),this.options.titleText&&(l.title=this.options.titleText),c=document.querySelector("base")?window.location.pathname+window.location.search:"",c=this.options.base||c,l.href=c+"#"+o,"always"===this.options.visible&&(l.style.opacity="1"),""===this.options.icon&&(l.style.font="1em/1 anchorjs-icons","left"===this.options.placement)&&(l.style.lineHeight="inherit"),"left"===this.options.placement?(l.style.position="absolute",l.style.marginLeft="-1.25em",l.style.paddingRight=".25em",l.style.paddingLeft=".25em",e[i].insertBefore(l,e[i].firstChild)):(l.style.marginLeft=".1875em",l.style.paddingRight=".1875em",l.style.paddingLeft=".1875em",e[i].appendChild(l))}for(i=0;i<p.length;i++)e.splice(p[i]-i,1);this.elements=this.elements.concat(e)}return this},this.remove=function(A){for(var e,t,o=d(A),i=0;i<o.length;i++)(t=o[i].querySelector(".anchorjs-link"))&&(-1!==(e=this.elements.indexOf(o[i]))&&this.elements.splice(e,1),o[i].removeChild(t));return this},this.removeAll=function(){this.remove(this.elements)},this.urlify=function(A){var e=document.createElement("textarea");return e.innerHTML=A,A=e.value,this.options.truncate||u(this.options),A.trim().replace(/'/gi,"").replace(/[& +$,:;=?@"#{}|^~[`%!'<>\]./()*\\\n\t\b\v\u00A0]/g,"-").replace(/-{2,}/g,"-").substring(0,this.options.truncate).replace(/^-+|-+$/gm,"").toLowerCase()},this.hasAnchorJSLink=function(A){var e=A.firstChild&&-1<(" "+A.firstChild.className+" ").indexOf(" anchorjs-link "),A=A.lastChild&&-1<(" "+A.lastChild.className+" ").indexOf(" anchorjs-link ");return e||A||!1}}});
 // @license-end
\ No newline at end of file
diff --git a/docs/site_libs/quarto-html/popper.min.js b/docs/site_libs/quarto-html/popper.min.js
index 2269d66..e3726d7 100644
--- a/docs/site_libs/quarto-html/popper.min.js
+++ b/docs/site_libs/quarto-html/popper.min.js
@@ -1,6 +1,6 @@
 /**
- * @popperjs/core v2.11.4 - MIT License
+ * @popperjs/core v2.11.7 - MIT License
  */
 
-!function(e,t){"object"==typeof exports&&"undefined"!=typeof module?t(exports):"function"==typeof define&&define.amd?define(["exports"],t):t((e="undefined"!=typeof globalThis?globalThis:e||self).Popper={})}(this,(function(e){"use strict";function t(e){if(null==e)return window;if("[object Window]"!==e.toString()){var t=e.ownerDocument;return t&&t.defaultView||window}return e}function n(e){return e instanceof t(e).Element||e instanceof Element}function r(e){return e instanceof t(e).HTMLElement||e instanceof HTMLElement}function o(e){return"undefined"!=typeof ShadowRoot&&(e instanceof t(e).ShadowRoot||e instanceof ShadowRoot)}var i=Math.max,a=Math.min,s=Math.round;function f(e,t){void 0===t&&(t=!1);var n=e.getBoundingClientRect(),o=1,i=1;if(r(e)&&t){var a=e.offsetHeight,f=e.offsetWidth;f>0&&(o=s(n.width)/f||1),a>0&&(i=s(n.height)/a||1)}return{width:n.width/o,height:n.height/i,top:n.top/i,right:n.right/o,bottom:n.bottom/i,left:n.left/o,x:n.left/o,y:n.top/i}}function c(e){var n=t(e);return{scrollLeft:n.pageXOffset,scrollTop:n.pageYOffset}}function p(e){return e?(e.nodeName||"").toLowerCase():null}function u(e){return((n(e)?e.ownerDocument:e.document)||window.document).documentElement}function l(e){return f(u(e)).left+c(e).scrollLeft}function d(e){return t(e).getComputedStyle(e)}function h(e){var t=d(e),n=t.overflow,r=t.overflowX,o=t.overflowY;return/auto|scroll|overlay|hidden/.test(n+o+r)}function m(e,n,o){void 0===o&&(o=!1);var i,a,d=r(n),m=r(n)&&function(e){var t=e.getBoundingClientRect(),n=s(t.width)/e.offsetWidth||1,r=s(t.height)/e.offsetHeight||1;return 1!==n||1!==r}(n),v=u(n),g=f(e,m),y={scrollLeft:0,scrollTop:0},b={x:0,y:0};return(d||!d&&!o)&&(("body"!==p(n)||h(v))&&(y=(i=n)!==t(i)&&r(i)?{scrollLeft:(a=i).scrollLeft,scrollTop:a.scrollTop}:c(i)),r(n)?((b=f(n,!0)).x+=n.clientLeft,b.y+=n.clientTop):v&&(b.x=l(v))),{x:g.left+y.scrollLeft-b.x,y:g.top+y.scrollTop-b.y,width:g.width,height:g.height}}function v(e){var 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t=-1!==navigator.userAgent.toLowerCase().indexOf("firefox");if(-1!==navigator.userAgent.indexOf("Trident")&&r(e)&&"fixed"===d(e).position)return null;var n=g(e);for(o(n)&&(n=n.host);r(n)&&["html","body"].indexOf(p(n))<0;){var i=d(n);if("none"!==i.transform||"none"!==i.perspective||"paint"===i.contain||-1!==["transform","perspective"].indexOf(i.willChange)||t&&"filter"===i.willChange||t&&i.filter&&"none"!==i.filter)return n;n=n.parentNode}return null}(e)||n}var j="top",E="bottom",D="right",A="left",L="auto",P=[j,E,D,A],M="start",k="end",W="viewport",B="popper",H=P.reduce((function(e,t){return e.concat([t+"-"+M,t+"-"+k])}),[]),T=[].concat(P,[L]).reduce((function(e,t){return e.concat([t,t+"-"+M,t+"-"+k])}),[]),R=["beforeRead","read","afterRead","beforeMain","main","afterMain","beforeWrite","write","afterWrite"];function S(e){var t=new Map,n=new Set,r=[];function o(e){n.add(e.name),[].concat(e.requires||[],e.requiresIfExists||[]).forEach((function(e){if(!n.has(e)){var 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diff --git a/docs/site_libs/quarto-html/quarto.js b/docs/site_libs/quarto-html/quarto.js
index c3935c7..3ebd49c 100644
--- a/docs/site_libs/quarto-html/quarto.js
+++ b/docs/site_libs/quarto-html/quarto.js
@@ -9,7 +9,7 @@ const layoutMarginEls = () => {
   // Find any conflicting margin elements and add margins to the
   // top to prevent overlap
   const marginChildren = window.document.querySelectorAll(
-    ".column-margin.column-container > * "
+    ".column-margin.column-container > *, .margin-caption, .aside"
   );
 
   let lastBottom = 0;
@@ -18,25 +18,14 @@ const layoutMarginEls = () => {
       // clear the top margin so we recompute it
       marginChild.style.marginTop = null;
       const top = marginChild.getBoundingClientRect().top + window.scrollY;
-      console.log({
-        childtop: marginChild.getBoundingClientRect().top,
-        scroll: window.scrollY,
-        top,
-        lastBottom,
-      });
       if (top < lastBottom) {
-        const margin = lastBottom - top;
+        const marginChildStyle = window.getComputedStyle(marginChild);
+        const marginBottom = parseFloat(marginChildStyle["marginBottom"]);
+        const margin = lastBottom - top + marginBottom;
         marginChild.style.marginTop = `${margin}px`;
       }
       const styles = window.getComputedStyle(marginChild);
       const marginTop = parseFloat(styles["marginTop"]);
-
-      console.log({
-        top,
-        height: marginChild.getBoundingClientRect().height,
-        marginTop,
-        total: top + marginChild.getBoundingClientRect().height + marginTop,
-      });
       lastBottom = top + marginChild.getBoundingClientRect().height + marginTop;
     }
   }
@@ -46,7 +35,15 @@ window.document.addEventListener("DOMContentLoaded", function (_event) {
   // Recompute the position of margin elements anytime the body size changes
   if (window.ResizeObserver) {
     const resizeObserver = new window.ResizeObserver(
-      throttle(layoutMarginEls, 50)
+      throttle(() => {
+        layoutMarginEls();
+        if (
+          window.document.body.getBoundingClientRect().width < 990 &&
+          isReaderMode()
+        ) {
+          quartoToggleReader();
+        }
+      }, 50)
     );
     resizeObserver.observe(window.document.body);
   }
diff --git a/docs/site_libs/quarto-nav/quarto-nav.js b/docs/site_libs/quarto-nav/quarto-nav.js
index 3b21201..f6a53b1 100644
--- a/docs/site_libs/quarto-nav/quarto-nav.js
+++ b/docs/site_libs/quarto-nav/quarto-nav.js
@@ -85,6 +85,17 @@ window.document.addEventListener("DOMContentLoaded", function () {
     }
   }
 
+  function dashboardOffset() {
+    const dashboardNavEl = window.document.getElementById(
+      "quarto-dashboard-header"
+    );
+    if (dashboardNavEl !== null) {
+      return dashboardNavEl.clientHeight;
+    } else {
+      return 0;
+    }
+  }
+
   function updateDocumentOffsetWithoutAnimation() {
     updateDocumentOffset(false);
   }
@@ -92,7 +103,7 @@ window.document.addEventListener("DOMContentLoaded", function () {
   function updateDocumentOffset(animated) {
     // set body offset
     const topOffset = headerOffset();
-    const bodyOffset = topOffset + footerOffset();
+    const bodyOffset = topOffset + footerOffset() + dashboardOffset();
     const bodyEl = window.document.body;
     bodyEl.setAttribute("data-bs-offset", topOffset);
     bodyEl.style.paddingTop = topOffset + "px";
@@ -205,9 +216,9 @@ window.document.addEventListener("DOMContentLoaded", function () {
   // Observe size changed for the header
   const headerEl = window.document.querySelector("header.fixed-top");
   if (headerEl && window.ResizeObserver) {
-    const observer = new window.ResizeObserver(
-      updateDocumentOffsetWithoutAnimation
-    );
+    const observer = new window.ResizeObserver(() => {
+      setTimeout(updateDocumentOffsetWithoutAnimation, 0);
+    });
     observer.observe(headerEl, {
       attributes: true,
       childList: true,
@@ -226,6 +237,7 @@ window.document.addEventListener("DOMContentLoaded", function () {
     const links = window.document.querySelectorAll("a");
     for (let i = 0; i < links.length; i++) {
       if (links[i].href) {
+        links[i].dataset.originalHref = links[i].href;
         links[i].href = links[i].href.replace(/\/index\.html/, "/");
       }
     }
@@ -233,7 +245,7 @@ window.document.addEventListener("DOMContentLoaded", function () {
     // Fixup any sharing links that require urls
     // Append url to any sharing urls
     const sharingLinks = window.document.querySelectorAll(
-      "a.sidebar-tools-main-item"
+      "a.sidebar-tools-main-item, a.quarto-navigation-tool, a.quarto-navbar-tools, a.quarto-navbar-tools-item"
     );
     for (let i = 0; i < sharingLinks.length; i++) {
       const sharingLink = sharingLinks[i];
diff --git a/docs/site_libs/quarto-search/autocomplete.umd.js b/docs/site_libs/quarto-search/autocomplete.umd.js
index 619c57c..ae0063a 100644
--- a/docs/site_libs/quarto-search/autocomplete.umd.js
+++ b/docs/site_libs/quarto-search/autocomplete.umd.js
@@ -1,3 +1,3 @@
-/*! @algolia/autocomplete-js 1.7.3 | MIT License | © Algolia, Inc. and contributors | https://github.com/algolia/autocomplete */
-!function(e,t){"object"==typeof exports&&"undefined"!=typeof module?t(exports):"function"==typeof define&&define.amd?define(["exports"],t):t((e="undefined"!=typeof globalThis?globalThis:e||self)["@algolia/autocomplete-js"]={})}(this,(function(e){"use strict";function t(e,t){var n=Object.keys(e);if(Object.getOwnPropertySymbols){var r=Object.getOwnPropertySymbols(e);t&&(r=r.filter((function(t){return Object.getOwnPropertyDescriptor(e,t).enumerable}))),n.push.apply(n,r)}return n}function n(e){for(var n=1;n<arguments.length;n++){var r=null!=arguments[n]?arguments[n]:{};n%2?t(Object(r),!0).forEach((function(t){o(e,t,r[t])})):Object.getOwnPropertyDescriptors?Object.defineProperties(e,Object.getOwnPropertyDescriptors(r)):t(Object(r)).forEach((function(t){Object.defineProperty(e,t,Object.getOwnPropertyDescriptor(r,t))}))}return e}function r(e){return r="function"==typeof Symbol&&"symbol"==typeof Symbol.iterator?function(e){return typeof e}:function(e){return e&&"function"==typeof Symbol&&e.constructor===Symbol&&e!==Symbol.prototype?"symbol":typeof e},r(e)}function o(e,t,n){return t in e?Object.defineProperty(e,t,{value:n,enumerable:!0,configurable:!0,writable:!0}):e[t]=n,e}function i(){return i=Object.assign||function(e){for(var t=1;t<arguments.length;t++){var n=arguments[t];for(var r in n)Object.prototype.hasOwnProperty.call(n,r)&&(e[r]=n[r])}return e},i.apply(this,arguments)}function u(e,t){if(null==e)return{};var n,r,o=function(e,t){if(null==e)return{};var n,r,o={},i=Object.keys(e);for(r=0;r<i.length;r++)n=i[r],t.indexOf(n)>=0||(o[n]=e[n]);return o}(e,t);if(Object.getOwnPropertySymbols){var i=Object.getOwnPropertySymbols(e);for(r=0;r<i.length;r++)n=i[r],t.indexOf(n)>=0||Object.prototype.propertyIsEnumerable.call(e,n)&&(o[n]=e[n])}return o}function a(e,t){return function(e){if(Array.isArray(e))return e}(e)||function(e,t){var n=null==e?null:"undefined"!=typeof Symbol&&e[Symbol.iterator]||e["@@iterator"];if(null==n)return;var r,o,i=[],u=!0,a=!1;try{for(n=n.call(e);!(u=(r=n.next()).done)&&(i.push(r.value),!t||i.length!==t);u=!0);}catch(e){a=!0,o=e}finally{try{u||null==n.return||n.return()}finally{if(a)throw o}}return i}(e,t)||l(e,t)||function(){throw new TypeError("Invalid attempt to destructure non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}()}function c(e){return function(e){if(Array.isArray(e))return s(e)}(e)||function(e){if("undefined"!=typeof Symbol&&null!=e[Symbol.iterator]||null!=e["@@iterator"])return Array.from(e)}(e)||l(e)||function(){throw new TypeError("Invalid attempt to spread non-iterable instance.\nIn order to be iterable, non-array objects must have a [Symbol.iterator]() method.")}()}function l(e,t){if(e){if("string"==typeof e)return s(e,t);var n=Object.prototype.toString.call(e).slice(8,-1);return"Object"===n&&e.constructor&&(n=e.constructor.name),"Map"===n||"Set"===n?Array.from(e):"Arguments"===n||/^(?:Ui|I)nt(?:8|16|32)(?:Clamped)?Array$/.test(n)?s(e,t):void 0}}function s(e,t){(null==t||t>e.length)&&(t=e.length);for(var n=0,r=new Array(t);n<t;n++)r[n]=e[n];return r}function p(e){return{current:e}}function f(e,t){var n=void 0;return function(){for(var r=arguments.length,o=new Array(r),i=0;i<r;i++)o[i]=arguments[i];n&&clearTimeout(n),n=setTimeout((function(){return e.apply(void 0,o)}),t)}}function d(e){return e.reduce((function(e,t){return e.concat(t)}),[])}var m=0;function v(){return"autocomplete-".concat(m++)}function h(e,t){return t.reduce((function(e,t){return e&&e[t]}),e)}function g(e){return 0===e.collections.length?0:e.collections.reduce((function(e,t){return e+t.items.length}),0)}var y=function(){},b="1.7.3",O=[{segment:"autocomplete-core",version:b}];function _(e,t){var n=t;return{then:function(t,r){return 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pr=["classNames","container","getEnvironmentProps","getFormProps","getInputProps","getItemProps","getLabelProps","getListProps","getPanelProps","getRootProps","panelContainer","panelPlacement","render","renderNoResults","renderer","detachedMediaQuery","components","translations"],mr={clearButton:"aa-ClearButton",detachedCancelButton:"aa-DetachedCancelButton",detachedContainer:"aa-DetachedContainer",detachedFormContainer:"aa-DetachedFormContainer",detachedOverlay:"aa-DetachedOverlay",detachedSearchButton:"aa-DetachedSearchButton",detachedSearchButtonIcon:"aa-DetachedSearchButtonIcon",detachedSearchButtonPlaceholder:"aa-DetachedSearchButtonPlaceholder",detachedSearchButtonQuery:"aa-DetachedSearchButtonQuery",form:"aa-Form",input:"aa-Input",inputWrapper:"aa-InputWrapper",inputWrapperPrefix:"aa-InputWrapperPrefix",inputWrapperSuffix:"aa-InputWrapperSuffix",item:"aa-Item",label:"aa-Label",list:"aa-List",loadingIndicator:"aa-LoadingIndicator",panel:"aa-Panel",panelLayout:"aa-PanelLayout 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n=b(t)>0;if(!O.value.core.openOnFocus&&!t.query)return n;var r=Boolean(y.current||O.value.renderer.renderNoResults);return!n&&r||n},__autocomplete_metadata:{userAgents:br,options:e}}))})),j=f(n({collections:[],completion:null,context:{},isOpen:!1,query:"",activeItemId:null,status:"idle"},O.value.core.initialState)),P={getEnvironmentProps:O.value.renderer.getEnvironmentProps,getFormProps:O.value.renderer.getFormProps,getInputProps:O.value.renderer.getInputProps,getItemProps:O.value.renderer.getItemProps,getLabelProps:O.value.renderer.getLabelProps,getListProps:O.value.renderer.getListProps,getPanelProps:O.value.renderer.getPanelProps,getRootProps:O.value.renderer.getRootProps},w={setActiveItemId:S.value.setActiveItemId,setQuery:S.value.setQuery,setCollections:S.value.setCollections,setIsOpen:S.value.setIsOpen,setStatus:S.value.setStatus,setContext:S.value.setContext,refresh:S.value.refresh,navigator:S.value.navigator},I=m((function(){return Ct.bind(O.value.renderer.renderer.createElement)})),A=m((function(){return Gt({autocomplete:S.value,autocompleteScopeApi:w,classNames:O.value.renderer.classNames,environment:O.value.core.environment,isDetached:_.value,placeholder:O.value.core.placeholder,propGetters:P,setIsModalOpen:k,state:j.current,translations:O.value.renderer.translations})}));function E(){Ht(A.value.panel,{style:_.value?{}:yr({panelPlacement:O.value.renderer.panelPlacement,container:A.value.root,form:A.value.form,environment:O.value.core.environment})})}function D(e){j.current=e;var t={autocomplete:S.value,autocompleteScopeApi:w,classNames:O.value.renderer.classNames,components:O.value.renderer.components,container:O.value.renderer.container,html:I.value,dom:A.value,panelContainer:_.value?A.value.detachedContainer:O.value.renderer.panelContainer,propGetters:P,state:j.current,renderer:O.value.renderer.renderer},r=!b(e)&&!y.current&&O.value.renderer.renderNoResults||O.value.renderer.render;!function(e){var t=e.autocomplete,r=e.autocompleteScopeApi,o=e.dom,i=e.propGetters,u=e.state;Vt(o.root,i.getRootProps(n({state:u,props:t.getRootProps({})},r))),Vt(o.input,i.getInputProps(n({state:u,props:t.getInputProps({inputElement:o.input}),inputElement:o.input},r))),Ht(o.label,{hidden:"stalled"===u.status}),Ht(o.loadingIndicator,{hidden:"stalled"!==u.status}),Ht(o.clearButton,{hidden:!u.query}),Ht(o.detachedSearchButtonQuery,{textContent:u.query}),Ht(o.detachedSearchButtonPlaceholder,{hidden:Boolean(u.query)})}(t),function(e,t){var r=t.autocomplete,o=t.autocompleteScopeApi,u=t.classNames,a=t.html,l=t.dom,c=t.panelContainer,s=t.propGetters,f=t.state,p=t.components,m=t.renderer;if(f.isOpen){c.contains(l.panel)||"loading"===f.status||c.appendChild(l.panel),l.panel.classList.toggle("aa-Panel--stalled","stalled"===f.status);var v=f.collections.filter((function(e){var t=e.source,n=e.items;return t.templates.noResults||n.length>0})).map((function(e,t){var l=e.source,c=e.items;return m.createElement("section",{key:t,className:u.source,"data-autocomplete-source-id":l.sourceId},l.templates.header&&m.createElement("div",{className:u.sourceHeader},l.templates.header({components:p,createElement:m.createElement,Fragment:m.Fragment,items:c,source:l,state:f,html:a})),l.templates.noResults&&0===c.length?m.createElement("div",{className:u.sourceNoResults},l.templates.noResults({components:p,createElement:m.createElement,Fragment:m.Fragment,source:l,state:f,html:a})):m.createElement("ul",i({className:u.list},s.getListProps(n({state:f,props:r.getListProps({source:l})},o))),c.map((function(e){var t=r.getItemProps({item:e,source:l});return m.createElement("li",i({key:t.id,className:u.item},s.getItemProps(n({state:f,props:t},o))),l.templates.item({components:p,createElement:m.createElement,Fragment:m.Fragment,item:e,state:f,html:a}))}))),l.templates.footer&&m.createElement("div",{className:u.sourceFooter},l.templates.footer({components:p,createElement:m.createElement,Fragment:m.Fragment,items:c,source:l,state:f,html:a})))})),d=m.createElement(m.Fragment,null,m.createElement("div",{className:u.panelLayout},v),m.createElement("div",{className:"aa-GradientBottom"})),y=v.reduce((function(e,t){return e[t.props["data-autocomplete-source-id"]]=t,e}),{});e(n(n({children:d,state:f,sections:v,elements:y},m),{},{components:p,html:a},o),l.panel)}else c.contains(l.panel)&&c.removeChild(l.panel)}(r,t)}function C(){var e=arguments.length>0&&void 0!==arguments[0]?arguments[0]:{};l();var t=O.value.renderer,n=t.components,r=u(t,gr);g.current=qt(r,O.value.core,{components:Bt(n,(function(e){return!e.value.hasOwnProperty("__autocomplete_componentName")})),initialState:j.current},e),v(),c(),S.value.refresh().then((function(){D(j.current)}))}function k(e){requestAnimationFrame((function(){var t=O.value.core.environment.document.body.contains(A.value.detachedOverlay);e!==t&&(e?(O.value.core.environment.document.body.appendChild(A.value.detachedOverlay),O.value.core.environment.document.body.classList.add("aa-Detached"),A.value.input.focus()):(O.value.core.environment.document.body.removeChild(A.value.detachedOverlay),O.value.core.environment.document.body.classList.remove("aa-Detached")))}))}return a((function(){var e=S.value.getEnvironmentProps({formElement:A.value.form,panelElement:A.value.panel,inputElement:A.value.input});return Ht(O.value.core.environment,e),function(){Ht(O.value.core.environment,Object.keys(e).reduce((function(e,t){return n(n({},e),{},o({},t,void 0))}),{}))}})),a((function(){var e=_.value?O.value.core.environment.document.body:O.value.renderer.panelContainer,t=_.value?A.value.detachedOverlay:A.value.panel;return _.value&&j.current.isOpen&&k(!0),D(j.current),function(){e.contains(t)&&e.removeChild(t)}})),a((function(){var e=O.value.renderer.container;return e.appendChild(A.value.root),function(){e.removeChild(A.value.root)}})),a((function(){var e=p((function(e){D(e.state)}),0);return h.current=function(t){var n=t.state,r=t.prevState;(_.value&&r.isOpen!==n.isOpen&&k(n.isOpen),_.value||!n.isOpen||r.isOpen||E(),n.query!==r.query)&&O.value.core.environment.document.querySelectorAll(".aa-Panel--scrollable").forEach((function(e){0!==e.scrollTop&&(e.scrollTop=0)}));e({state:n})},function(){h.current=void 0}})),a((function(){var e=p((function(){var e=_.value;_.value=O.value.core.environment.matchMedia(O.value.renderer.detachedMediaQuery).matches,e!==_.value?C({}):requestAnimationFrame(E)}),20);return O.value.core.environment.addEventListener("resize",e),function(){O.value.core.environment.removeEventListener("resize",e)}})),a((function(){if(!_.value)return function(){};function e(e){A.value.detachedContainer.classList.toggle("aa-DetachedContainer--modal",e)}function t(t){e(t.matches)}var n=O.value.core.environment.matchMedia(getComputedStyle(O.value.core.environment.document.documentElement).getPropertyValue("--aa-detached-modal-media-query"));e(n.matches);var r=Boolean(n.addEventListener);return r?n.addEventListener("change",t):n.addListener(t),function(){r?n.removeEventListener("change",t):n.removeListener(t)}})),a((function(){return requestAnimationFrame(E),function(){}})),n(n({},w),{},{update:C,destroy:function(){l()}})},e.getAlgoliaFacets=function(e){var t=hr({transformResponse:function(e){return e.facetHits}}),r=e.queries.map((function(e){return n(n({},e),{},{type:"facet"})}));return t(n(n({},e),{},{queries:r}))},e.getAlgoliaResults=Or,Object.defineProperty(e,"__esModule",{value:!0})}));
 
diff --git a/docs/site_libs/quarto-search/quarto-search.js b/docs/site_libs/quarto-search/quarto-search.js
index f5d852d..5f723d7 100644
--- a/docs/site_libs/quarto-search/quarto-search.js
+++ b/docs/site_libs/quarto-search/quarto-search.js
@@ -43,7 +43,7 @@ window.document.addEventListener("DOMContentLoaded", function (_event) {
   const mainEl = window.document.querySelector("main");
 
   // highlight matches on the page
-  if (query !== null && mainEl) {
+  if (query && mainEl) {
     // perform any highlighting
     highlight(escapeRegExp(query), mainEl);
 
@@ -57,7 +57,7 @@ window.document.addEventListener("DOMContentLoaded", function (_event) {
   // (e.g. if the user edits the query or clears it)
   let highlighting = true;
   const resetHighlighting = (searchTerm) => {
-    if (mainEl && highlighting && query !== null && searchTerm !== query) {
+    if (mainEl && highlighting && query && searchTerm !== query) {
       clearHighlight(query, mainEl);
       highlighting = false;
     }
@@ -98,6 +98,7 @@ window.document.addEventListener("DOMContentLoaded", function (_event) {
     classNames: {
       form: "d-flex",
     },
+    placeholder: language["search-text-placeholder"],
     translations: {
       clearButtonTitle: language["search-clear-button-title"],
       detachedCancelButtonText: language["search-detached-cancel-button-title"],
@@ -110,6 +111,8 @@ window.document.addEventListener("DOMContentLoaded", function (_event) {
       return item.href;
     },
     onStateChange({ state }) {
+      // If this is a file URL, note that
+
       // Perhaps reset highlighting
       resetHighlighting(state.query);
 
@@ -359,7 +362,8 @@ window.document.addEventListener("DOMContentLoaded", function (_event) {
                 state,
                 setActiveItemId,
                 setContext,
-                refresh
+                refresh,
+                quartoSearchOptions
               );
             },
           },
@@ -374,6 +378,32 @@ window.document.addEventListener("DOMContentLoaded", function (_event) {
     focusSearchInput();
   };
 
+  document.addEventListener("keyup", (event) => {
+    const { key } = event;
+    const kbds = quartoSearchOptions["keyboard-shortcut"];
+    const focusedEl = document.activeElement;
+
+    const isFormElFocused = [
+      "input",
+      "select",
+      "textarea",
+      "button",
+      "option",
+    ].find((tag) => {
+      return focusedEl.tagName.toLowerCase() === tag;
+    });
+
+    if (
+      kbds &&
+      kbds.includes(key) &&
+      !isFormElFocused &&
+      !document.activeElement.isContentEditable
+    ) {
+      event.preventDefault();
+      window.quartoOpenSearch();
+    }
+  });
+
   // Remove the labeleledby attribute since it is pointing
   // to a non-existent label
   if (quartoSearchOptions.type === "overlay") {
@@ -385,11 +415,30 @@ window.document.addEventListener("DOMContentLoaded", function (_event) {
     }
   }
 
+  function throttle(func, wait) {
+    let waiting = false;
+    return function () {
+      if (!waiting) {
+        func.apply(this, arguments);
+        waiting = true;
+        setTimeout(function () {
+          waiting = false;
+        }, wait);
+      }
+    };
+  }
+
   // If the main document scrolls dismiss the search results
   // (otherwise, since they're floating in the document they can scroll with the document)
-  window.document.body.onscroll = () => {
-    setIsOpen(false);
-  };
+  window.document.body.onscroll = throttle(() => {
+    // Only do this if we're not detached
+    // Bug #7117
+    // This will happen when the keyboard is shown on ios (resulting in a scroll)
+    // which then closed the search UI
+    if (!window.matchMedia(detachedMediaQuery).matches) {
+      setIsOpen(false);
+    }
+  }, 50);
 
   if (showSearchResults) {
     setIsOpen(true);
@@ -429,15 +478,27 @@ function configurePlugins(quartoSearchOptions) {
         const algoliaInsightsPlugin = createAlgoliaInsightsPlugin({
           insightsClient: window.aa,
           onItemsChange({ insights, insightsEvents }) {
-            const events = insightsEvents.map((event) => {
-              const maxEvents = event.objectIDs.slice(0, 20);
-              return {
-                ...event,
-                objectIDs: maxEvents,
-              };
+            const events = insightsEvents.flatMap((event) => {
+              // This API limits the number of items per event to 20
+              const chunkSize = 20;
+              const itemChunks = [];
+              const eventItems = event.items;
+              for (let i = 0; i < eventItems.length; i += chunkSize) {
+                itemChunks.push(eventItems.slice(i, i + chunkSize));
+              }
+              // Split the items into multiple events that can be sent
+              const events = itemChunks.map((items) => {
+                return {
+                  ...event,
+                  items,
+                };
+              });
+              return events;
             });
 
-            insights.viewedObjectIDs(...events);
+            for (const event of events) {
+              insights.viewedObjectIDs(event);
+            }
           },
         });
         return algoliaInsightsPlugin;
@@ -613,20 +674,30 @@ function showCopyLink(query, options) {
 /* Search Index Handling */
 // create the index
 var fuseIndex = undefined;
+var shownWarning = false;
+
+// fuse index options
+const kFuseIndexOptions = {
+  keys: [
+    { name: "title", weight: 20 },
+    { name: "section", weight: 20 },
+    { name: "text", weight: 10 },
+  ],
+  ignoreLocation: true,
+  threshold: 0.1,
+};
+
 async function readSearchData() {
   // Initialize the search index on demand
   if (fuseIndex === undefined) {
-    // create fuse index
-    const options = {
-      keys: [
-        { name: "title", weight: 20 },
-        { name: "section", weight: 20 },
-        { name: "text", weight: 10 },
-      ],
-      ignoreLocation: true,
-      threshold: 0.1,
-    };
-    const fuse = new window.Fuse([], options);
+    if (window.location.protocol === "file:" && !shownWarning) {
+      window.alert(
+        "Search requires JavaScript features disabled when running in file://... URLs. In order to use search, please run this document in a web server."
+      );
+      shownWarning = true;
+      return;
+    }
+    const fuse = new window.Fuse([], kFuseIndexOptions);
 
     // fetch the main search.json
     const response = await fetch(offsetURL("search.json"));
@@ -646,6 +717,7 @@ async function readSearchData() {
       );
     }
   }
+
   return fuseIndex;
 }
 
@@ -674,7 +746,8 @@ function renderItem(
   state,
   setActiveItemId,
   setContext,
-  refresh
+  refresh,
+  quartoSearchOptions
 ) {
   switch (item.type) {
     case kItemTypeDoc:
@@ -684,7 +757,9 @@ function renderItem(
         item.title,
         item.section,
         item.text,
-        item.href
+        item.href,
+        item.crumbs,
+        quartoSearchOptions
       );
     case kItemTypeMore:
       return createMoreCard(
@@ -709,15 +784,46 @@ function renderItem(
   }
 }
 
-function createDocumentCard(createElement, icon, title, section, text, href) {
+function createDocumentCard(
+  createElement,
+  icon,
+  title,
+  section,
+  text,
+  href,
+  crumbs,
+  quartoSearchOptions
+) {
   const iconEl = createElement("i", {
     class: `bi bi-${icon} search-result-icon`,
   });
   const titleEl = createElement("p", { class: "search-result-title" }, title);
+  const titleContents = [iconEl, titleEl];
+  const showParent = quartoSearchOptions["show-item-context"];
+  if (crumbs && showParent) {
+    let crumbsOut = undefined;
+    const crumbClz = ["search-result-crumbs"];
+    if (showParent === "root") {
+      crumbsOut = crumbs.length > 1 ? crumbs[0] : undefined;
+    } else if (showParent === "parent") {
+      crumbsOut = crumbs.length > 1 ? crumbs[crumbs.length - 2] : undefined;
+    } else {
+      crumbsOut = crumbs.length > 1 ? crumbs.join(" > ") : undefined;
+      crumbClz.push("search-result-crumbs-wrap");
+    }
+
+    const crumbEl = createElement(
+      "p",
+      { class: crumbClz.join(" ") },
+      crumbsOut
+    );
+    titleContents.push(crumbEl);
+  }
+
   const titleContainerEl = createElement(
     "div",
     { class: "search-result-title-container" },
-    [iconEl, titleEl]
+    titleContents
   );
 
   const textEls = [];
@@ -1099,17 +1205,19 @@ function algoliaSearch(query, limit, algoliaOptions) {
         const remappedHits = response.hits.map((hit) => {
           return hit.map((item) => {
             const newItem = { ...item };
-            ["href", "section", "title", "text"].forEach((keyName) => {
-              const mappedName = indexFields[keyName];
-              if (
-                mappedName &&
-                item[mappedName] !== undefined &&
-                mappedName !== keyName
-              ) {
-                newItem[keyName] = item[mappedName];
-                delete newItem[mappedName];
+            ["href", "section", "title", "text", "crumbs"].forEach(
+              (keyName) => {
+                const mappedName = indexFields[keyName];
+                if (
+                  mappedName &&
+                  item[mappedName] !== undefined &&
+                  mappedName !== keyName
+                ) {
+                  newItem[keyName] = item[mappedName];
+                  delete newItem[mappedName];
+                }
               }
-            });
+            );
             newItem.text = highlightMatch(query, newItem.text);
             return newItem;
           });
@@ -1120,8 +1228,34 @@ function algoliaSearch(query, limit, algoliaOptions) {
   });
 }
 
-function fuseSearch(query, fuse, fuseOptions) {
-  return fuse.search(query, fuseOptions).map((result) => {
+let subSearchTerm = undefined;
+let subSearchFuse = undefined;
+const kFuseMaxWait = 125;
+
+async function fuseSearch(query, fuse, fuseOptions) {
+  let index = fuse;
+  // Fuse.js using the Bitap algorithm for text matching which runs in
+  // O(nm) time (no matter the structure of the text). In our case this
+  // means that long search terms mixed with large index gets very slow
+  //
+  // This injects a subIndex that will be used once the terms get long enough
+  // Usually making this subindex is cheap since there will typically be
+  // a subset of results matching the existing query
+  if (subSearchFuse !== undefined && query.startsWith(subSearchTerm)) {
+    // Use the existing subSearchFuse
+    index = subSearchFuse;
+  } else if (subSearchFuse !== undefined) {
+    // The term changed, discard the existing fuse
+    subSearchFuse = undefined;
+    subSearchTerm = undefined;
+  }
+
+  // Search using the active fuse
+  const then = performance.now();
+  const resultsRaw = await index.search(query, fuseOptions);
+  const now = performance.now();
+
+  const results = resultsRaw.map((result) => {
     const addParam = (url, name, value) => {
       const anchorParts = url.split("#");
       const baseUrl = anchorParts[0];
@@ -1135,6 +1269,18 @@ function fuseSearch(query, fuse, fuseOptions) {
       section: result.item.section,
       href: addParam(result.item.href, kQueryArg, query),
       text: highlightMatch(query, result.item.text),
+      crumbs: result.item.crumbs,
     };
   });
+
+  // If we don't have a subfuse and the query is long enough, go ahead
+  // and create a subfuse to use for subsequent queries
+  if (now - then > kFuseMaxWait && subSearchFuse === undefined) {
+    subSearchTerm = query;
+    subSearchFuse = new window.Fuse([], kFuseIndexOptions);
+    resultsRaw.forEach((rr) => {
+      subSearchFuse.add(rr.item);
+    });
+  }
+  return results;
 }
diff --git a/index.qmd b/index.qmd
index 97f2191..ce6a9f7 100644
--- a/index.qmd
+++ b/index.qmd
@@ -14,7 +14,7 @@ Hi, I'm Santosh D. Bhosale, pharmacist by training and currently working as an a
 
 Using the versatility of mass spectrometry-based proteomics, I am exploring the properties of biologically important proteins.
 
-Precisely, I work on mass spectrometry-based proteomics technologies to address the questions related to biomedical research. These includes not only the qualitative and quantitative measurement of proteins, but also their post-translational modifications and interactions with other proteins. I use computational methods to understand the complexity of proteins.
+Precisely, I work on mass spectrometry-based proteomics technologies to address the questions related to biomedical research. These includes not only the qualitative and quantitative measurement of proteins, but also their post-translational modifications and interactions with other proteins. I use variety of computational methods to understand the complexity of proteins.
 
 ![](img/Proteomics.png){}