diff --git a/.github/workflows/ci_linux.yml b/.github/workflows/ci_linux.yml
index cbb6561..b0d519d 100644
--- a/.github/workflows/ci_linux.yml
+++ b/.github/workflows/ci_linux.yml
@@ -1,140 +1,65 @@
-name: CI on Linux
+# SPDX-FileCopyrightText: 2006-2023, Knut Reinert & Freie Universität Berlin
+# SPDX-FileCopyrightText: 2016-2023, Knut Reinert & MPI für molekulare Genetik
+# SPDX-License-Identifier: CC0-1.0
+
+name: Linux
 
 on:
   push:
     branches:
-      - 'master'
       - 'main'
   pull_request:
+  workflow_dispatch:
 
 concurrency:
   group: linux-${{ github.event.pull_request.number || github.ref }}
-  cancel-in-progress: true
+  cancel-in-progress: ${{ github.event_name != 'push' }}
 
 env:
-  CMAKE_VERSION: 3.10.3
-  SEQAN3_NO_VERSION_CHECK: 1
   TZ: Europe/Berlin
 
 defaults:
   run:
-    shell: bash -ex {0}
+    shell: bash -Eexuo pipefail {0}
 
 jobs:
   build:
-    name: ${{ matrix.name }}
-    runs-on: ubuntu-22.04
-    timeout-minutes: 120
+    runs-on: ubuntu-latest
+    name: ${{ matrix.compiler }}
+    if: github.repository_owner == 'seqan' || github.event_name == 'workflow_dispatch'
     strategy:
-      fail-fast: true
+      fail-fast: false
       matrix:
-        include:
-          - name: "Coverage gcc12"
-            cxx: "g++-12"
-            cc: "gcc-12"
-            build: coverage
-            build_type: Coverage
-
-          - name: "gcc12"
-            cxx: "g++-12"
-            cc: "gcc-12"
-            build_type: Release
-
-          - name: "gcc11"
-            cxx: "g++-11"
-            cc: "gcc-11"
-            build_type: Release
-
-          - name: "gcc10"
-            cxx: "g++-10"
-            cc: "gcc-10"
-            build_type: Release
-
+        compiler: ["clang-18", "clang-17", "gcc-14", "gcc-13", "gcc-12", "intel"]
+    container:
+      image: ghcr.io/seqan/${{ matrix.compiler }}
+      volumes:
+        - /home/runner:/home/runner
     steps:
       - name: Checkout
-        uses: actions/checkout@v3
-        with:
-          path: needle
-          fetch-depth: 2
-          submodules: recursive
-
-      - name: Add package source
-        run: bash ./needle/lib/seqan3/.github/workflows/scripts/configure_apt.sh
-
-      - name: Install CMake
-        run: bash ./needle/lib/seqan3/.github/workflows/scripts/install_cmake.sh
-
-      - name: Install ccache
-        run: sudo apt-get install --yes ccache
-
-      - name: Install compiler ${{ matrix.cxx }}
-        run: sudo apt-get install --yes ${{ matrix.cxx }}
-
-      - name: Install lcov
-        if: matrix.build == 'coverage'
-        run: |
-          sudo apt-get install --yes lcov
-          sudo update-alternatives --install /usr/bin/gcov gcov /usr/bin/gcov-12 100
+        uses: actions/checkout@v4
 
       - name: Load ccache
-        uses: actions/cache@v3
+        uses: actions/cache@v4
         with:
-          path: .ccache
-          key: ${{ runner.os }}-${{ matrix.name }}-ccache-${{ github.ref }}-${{ github.run_number }}
-          # Restoring: From current branch, otherwise from base branch, otherwise from any branch.
-          restore-keys: |
-            ${{ runner.os }}-${{ matrix.name }}-ccache-${{ github.ref }}
-            ${{ runner.os }}-${{ matrix.name }}-ccache-${{ github.base_ref }}
-            ${{ runner.os }}-${{ matrix.name }}-ccache-
-
-      - name: Tool versions
-        run: |
-          env cmake --version
-          env ${{ matrix.cxx }} --version
+          path: /home/runner/.ccache
+          save-always: true
+          key: ccache-${{ runner.os }}-${{ github.workflow }}-${{ matrix.compiler }}-${{ github.ref }}
 
       - name: Configure tests
-        env:
-          CXX: ${{ matrix.cxx }}
-          CC: ${{ matrix.cc }}
         run: |
-          mkdir build
-          cd build
-          cmake ../needle -DCMAKE_BUILD_TYPE=${{ matrix.build_type }} -DCMAKE_CXX_FLAGS="${{ matrix.cxx_flags }} -Wno-interference-size"
+          mkdir build && cd build
+          cmake .. -DCMAKE_BUILD_TYPE=Release
+          make gtest_main
 
       - name: Build tests
-        env:
-          CCACHE_BASEDIR: ${{ github.workspace }}
-          CCACHE_DIR: ${{ github.workspace }}/.ccache
-          CCACHE_COMPRESS: true
-          CCACHE_COMPRESSLEVEL: 6
-          CCACHE_MAXSIZE: 500M
-        run: |
-          ccache -p || true
-          cd build
-          make -k -j2 api_test cli_test
-          ccache -s || true
-
-      - name: Generate coverage baseline
-        if: matrix.build == 'coverage'
+        working-directory: build
         run: |
-          lcov --directory ./build/ --zerocounters
-          lcov --directory ./build/ --capture --initial --output-file ./build/coverage_report.baseline
+          ccache -z
+          make -k tests
+          ccache -svvx
 
       - name: Run tests
-        run: |
-          cd build
-          ctest . -j2 --output-on-failure
+        working-directory: build
+        run: ctest -j --output-on-failure --test-dir test
 
-      - name: Generate coverage report
-        if: matrix.build == 'coverage'
-        run: |
-          lcov --directory ./build/ --capture --output-file ./build/coverage_report.captured
-          lcov -a ./build/coverage_report.baseline -a ./build/coverage_report.captured --output-file ./build/coverage_report.total
-          lcov --remove ./build/coverage_report.total '/usr/*' '${{ github.workspace }}/needle/lib/*' '${{ github.workspace }}/needle/test/*' '${{ github.workspace }}/build/vendor/*' --output-file ./build/coverage_report
-
-      - name: Submit coverage report
-        if: matrix.build == 'coverage'
-        uses: codecov/codecov-action@v2
-        with:
-          files: ${{ github.workspace }}/build/coverage_report
-          root_dir: ${{ github.workspace }}/needle
diff --git a/.github/workflows/ci_macos.yml b/.github/workflows/ci_macos.yml
index 3e74e3b..bdd7397 100644
--- a/.github/workflows/ci_macos.yml
+++ b/.github/workflows/ci_macos.yml
@@ -1,115 +1,59 @@
-name: CI on macOS
+# SPDX-FileCopyrightText: 2006-2024 Knut Reinert & Freie Universität Berlin
+# SPDX-FileCopyrightText: 2016-2024 Knut Reinert & MPI für molekulare Genetik
+# SPDX-License-Identifier: CC0-1.0
+
+name: macOS
 
 on:
   push:
     branches:
-      - 'master'
       - 'main'
   pull_request:
+  workflow_dispatch:
 
 concurrency:
   group: macos-${{ github.event.pull_request.number || github.ref }}
-  cancel-in-progress: true
+  cancel-in-progress: ${{ github.event_name != 'push' }}
 
 env:
-  CMAKE_VERSION: 3.10.3
-  SEQAN3_NO_VERSION_CHECK: 1
   TZ: Europe/Berlin
 
 defaults:
   run:
-    shell: bash -ex {0}
+    shell: bash -Eeuxo pipefail {0}
 
 jobs:
   build:
-    name: ${{ matrix.name }}
-    runs-on: macos-12
-    timeout-minutes: 120
+    name: ${{ matrix.compiler }}
+    runs-on: macos-14
+    if: github.repository_owner == 'seqan' || github.event_name == 'workflow_dispatch'
     strategy:
-      fail-fast: true
+      fail-fast: false
       matrix:
-        include:
-          - name: "gcc12"
-            cxx: "g++-12"
-            cc: "gcc-12"
-            build_type: Release
-
-          - name: "gcc11"
-            cxx: "g++-11"
-            cc: "gcc-11"
-            build_type: Release
-
-          - name: "gcc10"
-            cxx: "g++-10"
-            cc: "gcc-10"
-            build_type: Release
-
+        compiler: ["clang-18", "clang-17", "gcc-14", "gcc-13", "gcc-12"]
     steps:
       - name: Checkout
-        uses: actions/checkout@v3
-        with:
-          path: needle
-          fetch-depth: 2
-          submodules: recursive
-
-      - name: Configure Homebrew
-        uses: Homebrew/actions/setup-homebrew@master
+        uses: actions/checkout@v4
 
-      - name: Install CMake
-        run: bash ./needle/lib/seqan3/.github/workflows/scripts/install_cmake.sh
-
-      - name: Install ccache
-        run: bash ./needle/lib/seqan3/.github/workflows/scripts/install_via_brew.sh ccache
-
-      - name: Install compiler ${{ matrix.cxx }}
-        run: bash ./needle/lib/seqan3/.github/workflows/scripts/install_via_brew.sh gcc $(echo "${{ matrix.cxx }}" | sed "s/g++-//g")
-
-      - name: Load ccache
-        uses: actions/cache@v3
+      - name: Setup toolchain
+        uses: seqan/actions/setup-toolchain@main
         with:
-          path: .ccache
-          key: ${{ runner.os }}-${{ matrix.name }}-ccache-${{ github.ref }}-${{ github.run_number }}
-          # Restoring: From current branch, otherwise from base branch, otherwise from any branch.
-          restore-keys: |
-            ${{ runner.os }}-${{ matrix.name }}-ccache-${{ github.ref }}
-            ${{ runner.os }}-${{ matrix.name }}-ccache-${{ github.base_ref }}
-            ${{ runner.os }}-${{ matrix.name }}-ccache-
-
-      - name: Tool versions
-        run: |
-          env cmake --version
-          env ${{ matrix.cxx }} --version
-          sudo xcode-select -s '/Applications/Xcode_13.4.1.app/Contents/Developer' # https://github.com/actions/runner-images/issues/6350
+          compiler: ${{ matrix.compiler }}
+          ccache_size: 75M
 
       - name: Configure tests
-        env:
-          CXX: ${{ matrix.cxx }}
-          CC: ${{ matrix.cc }}
         run: |
-          mkdir build
-          cd build
-          cmake ../needle -DCMAKE_BUILD_TYPE=${{ matrix.build_type }} -DCMAKE_CXX_FLAGS="${{ matrix.cxx_flags }} -Wno-interference-size"
+          mkdir build && cd build
+          cmake .. -DCMAKE_BUILD_TYPE=Release
+          make gtest_main
 
-      - name: Build application
-        env:
-          CCACHE_BASEDIR: ${{ github.workspace }}
-          CCACHE_DIR: ${{ github.workspace }}/.ccache
-          CCACHE_COMPRESS: true
-          CCACHE_COMPRESSLEVEL: 6
-          CCACHE_MAXSIZE: 500M
+      - name: Build tests
+        working-directory: build
         run: |
-          ccache -p || true
-          cd build
-          make -k -j3
-          ccache -s || true
+          ccache -z
+          make -k tests
+          ccache -svvx
 
-      - name: Build and run tests
-        env:
-          CCACHE_BASEDIR: ${{ github.workspace }}
-          CCACHE_DIR: ${{ github.workspace }}/.ccache
-          CCACHE_COMPRESS: true
-          CCACHE_COMPRESSLEVEL: 6
-          CCACHE_MAXSIZE: 500M
-        run: |
-          cd build
-          ctest . -j3 --output-on-failure
+      - name: Run tests
+        working-directory: build
+        run: ctest -j --output-on-failure --test-dir test
diff --git a/.github/workflows/ci_misc.yml b/.github/workflows/ci_misc.yml
deleted file mode 100644
index 7ea63ad..0000000
--- a/.github/workflows/ci_misc.yml
+++ /dev/null
@@ -1,137 +0,0 @@
-name: CI misc
-
-on:
-  push:
-    branches:
-      - 'master'
-      - 'main'
-  pull_request:
-
-concurrency:
-  group: misc-${{ github.event.pull_request.number || github.ref }}
-  cancel-in-progress: true
-
-env:
-  SEQAN3_NO_VERSION_CHECK: 1
-  TZ: Europe/Berlin
-
-defaults:
-  run:
-    shell: bash -ex {0}
-
-jobs:
-  build:
-    name: ${{ matrix.name }}
-    runs-on: ubuntu-22.04
-    timeout-minutes: 120
-    strategy:
-      fail-fast: false
-      matrix:
-        include:
-          - name: "Documentation"
-            build: documentation
-            build_threads: 2
-            test_threads: 2
-            cmake: 3.10.3
-            doxygen: 1.9.4
-            requires_toolchain: false
-            requires_ccache: false
-            skip_build_tests: true
-            skip_run_tests: false
-
-    steps:
-      - name: Checkout
-        uses: actions/checkout@v3
-        with:
-          path: needle
-          fetch-depth: 2
-          submodules: recursive
-
-      - name: Add package source
-        run: bash ./needle/lib/seqan3/.github/workflows/scripts/configure_apt.sh
-
-      - name: Install CMake
-        env:
-          BUILD: ${{ matrix.build }}
-          CMAKE_VERSION: ${{ matrix.cmake }}
-        run: bash ./needle/lib/seqan3/.github/workflows/scripts/install_cmake.sh
-
-      - name: Install Doxygen
-        if: matrix.build == 'documentation'
-        env:
-          DOXYGEN_VERSION: ${{ matrix.doxygen }}
-        run: bash ./needle/lib/seqan3/.github/workflows/scripts/install_doxygen.sh
-
-      - name: Install ccache
-        if: matrix.requires_ccache
-        run: sudo apt-get install --yes ccache
-
-      - name: Install compiler ${{ matrix.cxx }}
-        if: matrix.requires_toolchain
-        run: sudo apt-get install --yes ${{ matrix.cxx }}
-
-      - name: Load ccache
-        if: matrix.requires_ccache
-        uses: actions/cache@v3
-        with:
-          path: .ccache
-          key: ${{ matrix.name }}-ccache-${{ github.ref }}-${{ github.run_number }}
-          # Restoring: From current branch, otherwise from base branch, otherwise from any branch.
-          restore-keys: |
-            ${{ matrix.name }}-ccache-${{ github.ref }}
-            ${{ matrix.name }}-ccache-${{ github.base_ref }}
-            ${{ matrix.name }}-ccache-
-
-      - name: Tool versions
-        run: |
-          env cmake --version
-          env doxygen --version || true
-          env ${{ matrix.cxx }} --version || true
-
-      - name: Configure tests
-        env:
-          CXX: ${{ matrix.cxx }}
-          CC: ${{ matrix.cc }}
-        run: |
-          mkdir build
-          cd build
-          cmake ../needle -DCMAKE_BUILD_TYPE=${{ matrix.build_type }} -DCMAKE_CXX_FLAGS="${{ matrix.cxx_flags }} -Wno-interference-size"
-
-      - name: Build tests
-        if: ${{!matrix.skip_build_tests}}
-        env:
-          CCACHE_BASEDIR: ${{ github.workspace }}
-          CCACHE_DIR: ${{ github.workspace }}/.ccache
-          CCACHE_COMPRESS: true
-          CCACHE_COMPRESSLEVEL: 6
-          CCACHE_MAXSIZE: 500M
-        run: |
-          ccache -p || true
-          cd build
-          make -k -j${{ matrix.build_threads }}
-          ccache -s || true
-
-      - name: Run tests
-        if: ${{!matrix.skip_run_tests}}
-        run: |
-          cd build
-          if [[ "${{ matrix.build }}" =~ ^(documentation)$ ]]; then
-            make -k -j2 doc 2>doxygen_warnings.txt
-            cat doxygen_warnings.txt
-            test ! -s doxygen_warnings.txt
-          else
-            ctest . -j${{ matrix.test_threads }} --output-on-failure
-          fi
-
-      - name: Package documentation
-        if: matrix.build == 'documentation'
-        continue-on-error: true
-        run: tar -zcf documentation.tar.gz build
-
-      - name: Upload documentation
-        if: matrix.build == 'documentation'
-        continue-on-error: true
-        uses: actions/upload-artifact@v3
-        with:
-          name: documentation
-          path: documentation.tar.gz
diff --git a/.github/workflows/ci_sanitizer.yml b/.github/workflows/ci_sanitizer.yml
new file mode 100644
index 0000000..c8891db
--- /dev/null
+++ b/.github/workflows/ci_sanitizer.yml
@@ -0,0 +1,99 @@
+# SPDX-FileCopyrightText: 2006-2024 Knut Reinert & Freie Universität Berlin
+# SPDX-FileCopyrightText: 2016-2024 Knut Reinert & MPI für molekulare Genetik
+# SPDX-License-Identifier: CC0-1.0
+
+name: Sanitizer
+
+on:
+  schedule:
+    - cron: "0 6 * * SAT"
+  workflow_dispatch:
+
+concurrency:
+  group: sanitizer-actions
+  cancel-in-progress: true
+
+env:
+  TZ: Europe/Berlin
+  ASAN_OPTIONS: strict_string_checks=1:detect_stack_use_after_return=1:check_initialization_order=1:strict_init_order=1:detect_leaks=1
+  TSAN_OPTIONS: ignore_noninstrumented_modules=1
+  UBSAN_OPTIONS: print_stacktrace=1
+
+defaults:
+  run:
+    shell: bash -Eeuxo pipefail {0}
+
+jobs:
+  build:
+    name: ${{ matrix.name }} ${{ matrix.build_type }} ${{ matrix.os }}
+    runs-on: ${{ matrix.os }}
+    if: github.repository_owner == 'seqan' || github.event_name == 'workflow_dispatch'
+    strategy:
+      fail-fast: false
+      matrix:
+        name: [ASan, TSan, UBSan]
+        os: [ubuntu-latest, macos-14]
+        build_type: [Release, RelWithDebInfo, Debug]
+        exclude:
+          - name: "TSan"
+            os: macos-14
+        include:
+          - name: "ASan"
+            os: ubuntu-latest
+            cxx_flags: "-fno-omit-frame-pointer -fsanitize=address -Wno-maybe-uninitialized"
+
+          - name: "ASan"
+            os: macos-14
+            cxx_flags: "-fno-omit-frame-pointer -fsanitize=address"
+
+          - name: "TSan"
+            cxx_flags: "-fno-omit-frame-pointer -fsanitize=thread"
+
+          - name: "UBSan"
+            os: ubuntu-latest
+            cxx_flags: "-fno-omit-frame-pointer -fsanitize=undefined,float-divide-by-zero"
+
+          - name: "UBSan"
+            os: macos-14
+            cxx_flags: "-fno-omit-frame-pointer -fsanitize=undefined,float-divide-by-zero,local-bounds,nullability -fno-sanitize=function -Wno-pass-failed"
+
+          - os: macos-14
+            compiler: clang-18
+
+          - os: ubuntu-latest
+            compiler: gcc-14
+            image: ghcr.io/seqan/gcc-14
+
+          - name: "TSan"
+            os: ubuntu-latest
+            compiler: clang-18
+            image: ghcr.io/seqan/clang-18
+    container:
+      image: ${{ matrix.image || '' }}
+      volumes:
+        - /home/runner:/home/runner
+    steps:
+      - name: Checkout
+        uses: actions/checkout@v4
+
+      - name: Setup compiler
+        if: contains(matrix.os, 'macos')
+        uses: seqan/actions/setup-compiler@main
+        with:
+          compiler: ${{ matrix.compiler }}
+
+      - name: Configure tests
+        run: |
+          mkdir build && cd build
+          cmake .. -DCMAKE_BUILD_TYPE=${{ matrix.build_type }} \
+                   -DCMAKE_CXX_FLAGS="${{ matrix.cxx_flags }}"
+          make gtest_main
+
+      - name: Build tests
+        working-directory: build
+        run: make -k tests
+
+      - name: Run tests
+        working-directory: build
+        run: ctest -j --output-on-failure --test-dir test
+