diff --git a/.github/workflows/python-ci-full.yml b/.github/workflows/python-ci-full.yml
index 32691df14c..eeab018ca7 100644
--- a/.github/workflows/python-ci-full.yml
+++ b/.github/workflows/python-ci-full.yml
@@ -25,7 +25,7 @@ jobs:
         # os: [ubuntu-22.04, macos-12, windows-2019]
         # TODO: add 3.12
         # https://github.com/single-cell-data/TileDB-SOMA/issues/1849
-        python-version: ['3.7', '3.8', '3.9', '3.10', '3.11']
+        python-version: ['3.8', '3.9', '3.10', '3.11']
         include:
           - runs-on: ubuntu-22.04
             cc: gcc-11
diff --git a/.github/workflows/python-ci-minimal.yml b/.github/workflows/python-ci-minimal.yml
index d0ace20832..eae233e2f3 100644
--- a/.github/workflows/python-ci-minimal.yml
+++ b/.github/workflows/python-ci-minimal.yml
@@ -22,7 +22,7 @@ jobs:
       fail-fast: true
       matrix:
         os: [ubuntu-22.04, macos-12]
-        python-version: ['3.7', '3.11']
+        python-version: ['3.8', '3.11']
         include:
           - os: ubuntu-22.04
             cc: gcc-11
diff --git a/apis/python/setup.py b/apis/python/setup.py
index d35388242c..4f40fb80e2 100644
--- a/apis/python/setup.py
+++ b/apis/python/setup.py
@@ -277,7 +277,6 @@ def run(self):
         "Operating System :: MacOS :: MacOS X",
         "Operating System :: Microsoft :: Windows",
         "Programming Language :: Python",
-        "Programming Language :: Python :: 3.7",
         "Programming Language :: Python :: 3.8",
         "Programming Language :: Python :: 3.9",
         "Programming Language :: Python :: 3.10",
@@ -316,18 +315,10 @@ def run(self):
     zip_safe=False,
     setup_requires=["pybind11"],
     install_requires=[
-        # Needed for Python 3.7 which anndata 0.9 doesn't support but we do
-        "anndata < 0.9; python_version<'3.8'",
         # Tracked in https://github.com/single-cell-data/TileDB-SOMA/issues/1785
         "anndata != 0.10.0; python_version>='3.8'",
         "attrs>=22.2",
-        "numba>=0.58.0; python_version>='3.8'",
-        # Older numba version needed for Python3.7.
-        # This older numba version was also incompatible with newer numpy
-        # versions, and the old pip solver (<=2020) needed us to explicate
-        # that constraint here (issue #1051).
-        "numba==0.56.4; python_version<'3.8'",
-        "numpy>=1.18,<1.24; python_version<'3.8'",
+        "numba>=0.58.0",
         "pandas",
         # TODO: once we no longer support Python 3.7, remove this and pin to pyarrow >= 14.0.1
         # https://github.com/single-cell-data/TileDB-SOMA/issues/1926
@@ -350,7 +341,7 @@ def run(self):
             "typeguard<3.0",
         ]
     },
-    python_requires=">=3.7",
+    python_requires=">=3.8",
     cmdclass={"build_ext": build_ext, "bdist_wheel": bdist_wheel},
     version=version.getVersion(),
 )
diff --git a/apis/python/tests/test_soma_array.py b/apis/python/tests/test_soma_array.py
index e090cada8e..f10752d87f 100644
--- a/apis/python/tests/test_soma_array.py
+++ b/apis/python/tests/test_soma_array.py
@@ -74,11 +74,7 @@ def test_soma_array_var_x_data():
 
     # iterate read batches until all results have been processed
     total_num_rows = 0
-    # The := "walrus" operator is really the appropriate thing here, but alas, is not
-    # supported in Python 3.7 which we do wish to preserve compatibility with.
-    # while arrow_table := sr.read_next():
-    while not sr.results_complete():
-        arrow_table = sr.read_next()
+    while arrow_table := sr.read_next():
         total_num_rows += arrow_table.num_rows
 
     assert total_num_rows == 4848644
@@ -219,13 +215,7 @@ def test_soma_array_obs_slice_x():
 
     # iterate read batches until all results have been processed
     total_num_rows = 0
-    # The := "walrus" operator is really the appropriate thing here, but alas, is not
-    # supported in Python 3.7 which we do wish to preserve compatibility with.
-    # while x_data := sr.read_next():
-    while True:
-        x_data = sr.read_next()
-        if not x_data:
-            break
+    while x_data := sr.read_next():
         total_num_rows += x_data.num_rows
 
     assert total_num_rows == 110280