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Burrows-Wheeler Transform Index

The Burrows-Wheeler Transform (BWT) index is generated from the Genome Reference Consortium Human Build 38 (GRCh38), specifically version GCA_000001405.15 using the no_alt_analysis_set.

For more detailed information about this reference genome, please refer to the build GRCh38 documentation under “Genome Builds” section.

Generating BWT Index

The index is generated using BWA indexing algorithm.

Generate BWT index
sentieon bwa index reference.fasta

Implementation with Sentieon

Sentieon implementation replicates the original BWA code. The current reference index was generated using Sentieon version 202308.01, corresponding to BWA version 0.7.17.