diff --git a/.github/workflows/ccip-live-network-tests.yml b/.github/workflows/ccip-live-network-tests.yml
index 890b8fd872..089fcf739b 100644
--- a/.github/workflows/ccip-live-network-tests.yml
+++ b/.github/workflows/ccip-live-network-tests.yml
@@ -30,8 +30,6 @@ concurrency:
 env:
   CHAINLINK_IMAGE: ${{ secrets.QA_AWS_ACCOUNT_NUMBER }}.dkr.ecr.${{ secrets.QA_AWS_REGION }}.amazonaws.com/chainlink
   CHAINLINK_VERSION: ${{ github.sha }}
-  CHAINLINK_TEST_VERSION: ${{ github.sha }}
-  ENV_JOB_IMAGE: ${{ secrets.QA_AWS_ACCOUNT_NUMBER }}.dkr.ecr.${{ secrets.QA_AWS_REGION }}.amazonaws.com/chainlink-ccip-tests:${{ github.sha }}
   INTERNAL_DOCKER_REPO: ${{ secrets.QA_AWS_ACCOUNT_NUMBER }}.dkr.ecr.${{ secrets.QA_AWS_REGION }}.amazonaws.com
   AWS_ECR_REPO_PUBLIC_REGISTRY: public.ecr.aws
   E2E_TEST_CHAINLINK_IMAGE: ${{ secrets.QA_AWS_ACCOUNT_NUMBER }}.dkr.ecr.${{ secrets.QA_AWS_REGION }}.amazonaws.com/chainlink
@@ -101,6 +99,7 @@ jobs:
 
   build-test-image:
     environment: integration
+    if: ${{ github.event_name == 'workflow_dispatch' && inputs.test_type == 'load' }}
     permissions:
       id-token: write
       contents: read
@@ -149,6 +148,8 @@ jobs:
       SLACK_CHANNEL: ${{ secrets.QA_SLACK_CHANNEL }}
       TEST_LOG_LEVEL: info
       REF_NAME: ${{ github.head_ref || github.ref_name }}
+      CHAINLINK_TEST_VERSION: ${{ github.sha }}
+      ENV_JOB_IMAGE: ${{ secrets.QA_AWS_ACCOUNT_NUMBER }}.dkr.ecr.${{ secrets.QA_AWS_REGION }}.amazonaws.com/chainlink-ccip-tests:${{ github.sha }}
       ENV_JOB_IMAGE_BASE: ${{ secrets.QA_AWS_ACCOUNT_NUMBER }}.dkr.ecr.${{ secrets.QA_AWS_REGION }}.amazonaws.com/chainlink-ccip-tests
 
     steps:
@@ -231,10 +232,10 @@ jobs:
           should_cleanup: false
           
   ccip-smoke-test:
-    name: CCIP smoke Test
+    name: CCIP smoke Test ${{ matrix.lanes.name }}
     environment: integration
     runs-on: ubuntu-latest
-    needs: [ build-chainlink, build-test-image ]
+    needs: [ build-chainlink ]
     # if the event is a scheduled event or the test type is smoke and no previous job failed
     if: ${{ (github.event_name == 'schedule' || inputs.test_type == 'smoke') && !contains(needs.*.result, 'failure') }}
     permissions:
@@ -249,10 +250,69 @@ jobs:
       SLACK_CHANNEL: ${{ secrets.QA_SLACK_CHANNEL }}
       TEST_LOG_LEVEL: info
       REF_NAME: ${{ github.head_ref || github.ref_name }}
-      ENV_JOB_IMAGE_BASE: ${{ secrets.QA_AWS_ACCOUNT_NUMBER }}.dkr.ecr.${{ secrets.QA_AWS_REGION }}.amazonaws.com/chainlink-ccip-tests
-
+    strategy:
+      fail-fast: false
+      matrix:
+        lanes:
+          - name: 'ARBITRUM_MAINNET'
+            pairs: 'ARBITRUM_MAINNET,BSC_MAINNET;ARBITRUM_MAINNET,OPTIMISM_MAINNET'
+            enabled: true
+            phaseTimeout: 20m
+          - name: 'AVALANCHE_MAINNET'
+            pairs: 'AVALANCHE_MAINNET,ARBITRUM_MAINNET;AVALANCHE_MAINNET,BASE_MAINNET;AVALANCHE_MAINNET,BSC_MAINNET;AVALANCHE_MAINNET,OPTIMISM_MAINNET;AVALANCHE_MAINNET,POLYGON_MAINNET;AVALANCHE_MAINNET,WEMIX_MAINNET'
+            enabled: true
+            phaseTimeout: 20m
+          - name: 'BASE_MAINNET'
+            pairs: 'BASE_MAINNET,ARBITRUM_MAINNET;BASE_MAINNET,BSC_MAINNET;BASE_MAINNET,OPTIMISM_MAINNET;BASE_MAINNET,POLYGON_MAINNET'
+            enabled: true
+            phaseTimeout: 20m
+          - name: 'BLAST_MAINNET'
+            pairs: 'BLAST_MAINNET,ARBITRUM_MAINNET;BLAST_MAINNET,BASE_MAINNET;BLAST_MAINNET,BSC_MAINNET'
+            enabled: true
+            phaseTimeout: 20m
+          - name: 'BSC_MAINNET'
+            pairs: 'BSC_MAINNET,OPTIMISM_MAINNET;BSC_MAINNET,POLYGON_MAINNET;BSC_MAINNET,WEMIX_MAINNET'
+            enabled: true
+            phaseTimeout: 20m
+          - name: 'ETHEREUM_MAINNET 1'
+            pairs: 'ETHEREUM_MAINNET,ARBITRUM_MAINNET;ETHEREUM_MAINNET,AVALANCHE_MAINNET;ETHEREUM_MAINNET,BASE_MAINNET;ETHEREUM_MAINNET,BLAST_MAINNET;ETHEREUM_MAINNET,BSC_MAINNET;ETHEREUM_MAINNET,CELO_MAINNET;ETHEREUM_MAINNET,GNOSIS_MAINNET;ETHEREUM_MAINNET,OPTIMISM_MAINNET;ETHEREUM_MAINNET,POLYGON_MAINNET;ETHEREUM_MAINNET,WEMIX_MAINNET'
+            enabled: true
+            phaseTimeout: 40m
+          - name: 'ETHEREUM_MAINNET 2'
+            pairs: 'ETHEREUM_MAINNET,METIS_ANDROMEDA;ETHEREUM_MAINNET,ZKSYNC_MAINNET'
+            enabled: true
+            phaseTimeout: 90m
+          - name: 'GNOSIS_MAINNET'
+            pairs: 'GNOSIS_MAINNET,ARBITRUM_MAINNET;GNOSIS_MAINNET,AVALANCHE_MAINNET;GNOSIS_MAINNET,BASE_MAINNET;GNOSIS_MAINNET,BSC_MAINNET;GNOSIS_MAINNET,OPTIMISM_MAINNET;GNOSIS_MAINNET,POLYGON_MAINNET'
+            enabled: true
+            phaseTimeout: 20m
+          - name: 'METIS_ANDROMEDA'
+            pairs: 'METIS_ANDROMEDA,ARBITRUM_MAINNET'
+            enabled: true
+            phaseTimeout: 60m
+          - name: 'MODE_MAINNET'
+            pairs: 'MODE_MAINNET,OPTIMISM_MAINNET;MODE_MAINNET,ARBITRUM_MAINNET;MODE_MAINNET,BASE_MAINNET;MODE_MAINNET,BSC_MAINNET'
+            enabled: true
+            phaseTimeout: 20m
+          - name: 'OPTIMISM_MAINNET'
+            pairs: 'OPTIMISM_MAINNET,POLYGON_MAINNET;OPTIMISM_MAINNET,WEMIX_MAINNET'
+            enabled: true
+            phaseTimeout: 20m
+          - name: 'POLYGON_MAINNET'
+            pairs: 'POLYGON_MAINNET,ARBITRUM_MAINNET;POLYGON_MAINNET,WEMIX_MAINNET'
+            enabled: true
+            phaseTimeout: 20m
+          - name: 'WEMIX_MAINNET'
+            pairs: 'WEMIX_MAINNET,ARBITRUM_MAINNET;WEMIX_MAINNET,KROMA_MAINNET'
+            enabled: true
+            phaseTimeout: 20m
+          - name: 'ZKSYNC_MAINNET'
+            pairs: 'ZKSYNC_MAINNET,ARBITRUM_MAINNET'
+            enabled: true
+            phaseTimeout: 90m
     steps:
       - name: Collect Metrics
+        if: ${{ matrix.lanes.enabled == true }}
         id: collect-gha-metrics
         uses: smartcontractkit/push-gha-metrics-action@dea9b546553cb4ca936607c2267a09c004e4ab3f # v3.0.0
         with:
@@ -263,10 +323,12 @@ jobs:
           this-job-name: CCIP Smoke Test
         continue-on-error: true
       - name: Checkout the repo
+        if: ${{ matrix.lanes.enabled == true }}
         uses: actions/checkout@9bb56186c3b09b4f86b1c65136769dd318469633 # v4.1.2
         with:
           ref: ${{ env.REF_NAME }}
       - name: Prepare Base64 TOML override
+        if: ${{ matrix.lanes.enabled == true }}
         id: set_override_config
         shell: bash
         run: |
@@ -279,19 +341,19 @@ jobs:
             echo "base_64_override=$BASE64_CCIP_CONFIG_OVERRIDE" >> $GITHUB_OUTPUT
           fi
           if [[ "${{ github.event_name }}" == "schedule" ]]; then
-             BASE64_CCIP_CONFIG_OVERRIDE=$(base64 -w 0 -i ./integration-tests/ccip-tests/testconfig/override/${{ matrix.config }})
+             BASE64_CCIP_CONFIG_OVERRIDE=$(base64 -w 0 -i ./integration-tests/ccip-tests/testconfig/override/mainnet.toml)
              echo ::add-mask::$BASE64_CCIP_CONFIG_OVERRIDE
              echo "base_64_override=$BASE64_CCIP_CONFIG_OVERRIDE" >> $GITHUB_OUTPUT
              echo "SLACK_USER=${{ secrets.QA_SLACK_USER }}" >> $GITHUB_ENV
            fi
       - name: step summary
+        if: ${{ matrix.lanes.enabled == true }}
         shell: bash
         run: |
           echo "### chainlink image used for this test run :link:" >>$GITHUB_STEP_SUMMARY
           echo "\`${{ env.CHAINLINK_VERSION }}\`" >> $GITHUB_STEP_SUMMARY
-          echo "### chainlink-tests image tag for this test run :ship:" >>$GITHUB_STEP_SUMMARY
-          echo "\`${{ env.CHAINLINK_TEST_VERSION }}\`" >> $GITHUB_STEP_SUMMARY
       - name: Prepare Base64 TOML override for CCIP secrets
+        if: ${{ matrix.lanes.enabled == true }}
         uses: ./.github/actions/setup-create-base64-config-ccip
         id: setup_create_base64_config_ccip
         with:
@@ -301,6 +363,7 @@ jobs:
           logstreamLogTargets: ${{ vars.LOGSTREAM_LOG_TARGETS }}
       - name: Run Tests
         uses: smartcontractkit/chainlink-github-actions/chainlink-testing-framework/run-tests@94cb11f4bd545607a2f221c6685052b3abee723d # v2.3.32
+        if: ${{ matrix.lanes.enabled == true }}
         env:
           TEST_SUITE: smoke
           TEST_ARGS: -test.timeout 900h
@@ -312,8 +375,10 @@ jobs:
           BASE64_CCIP_CONFIG_OVERRIDE: ${{ steps.setup_create_base64_config_ccip.outputs.base64_config }},${{ steps.set_override_config.outputs.base_64_override }}
           TEST_BASE64_CCIP_CONFIG_OVERRIDE: ${{ steps.setup_create_base64_config_ccip.outputs.base64_config }},${{ steps.set_override_config.outputs.base_64_override }}
           E2E_TEST_GRAFANA_DASHBOARD_URL: "/d/ddf75041-1e39-42af-aa46-361fe4c36e9e/ci-e2e-tests-logs"
+          OVERRIDE_NETWORK_PAIRS: ${{ matrix.lanes.pairs }}
+          OVERRIDE_PHASE_TIMEOUT: ${{ matrix.lanes.phaseTimeout }}
         with:
-          test_command_to_run: cd ./integration-tests/ccip-tests && go test -v -timeout 3h -count=1 -p 30 -json -run ^TestSmokeCCIPForBidirectionalLane$ ./smoke 2>&1 | tee /tmp/gotest.log | gotestloghelper -ci -singlepackage -hidepassingtests=false
+          test_command_to_run: cd ./integration-tests/ccip-tests && go test -v -timeout 3h -count=1 -p 30 -json -run ^TestSmokeCCIPForGivenNetworkPairs$ ./smoke 2>&1 | tee /tmp/gotest.log | gotestloghelper -ci -singlepackage -hidepassingtests=false
           test_download_vendor_packages_command: cd ./integration-tests && go mod download
           # Other default test secrets loaded from dotenv Github Secret.
           test_secrets_defaults_base64: ${{ secrets.CCIP_DEFAULT_TEST_SECRETS }}
@@ -322,7 +387,6 @@ jobs:
           go_mod_path: ./integration-tests/go.mod
           QA_AWS_REGION: ${{ secrets.QA_AWS_REGION }}
           QA_AWS_ROLE_TO_ASSUME: ${{ secrets.QA_AWS_ROLE_TO_ASSUME }}
-          QA_KUBECONFIG: ${{ secrets.QA_KUBECONFIG }}
           triggered_by: ${{ env.TEST_TRIGGERED_BY }}
           artifacts_location: ./integration-tests/smoke/logs/payload_ccip.json
           aws_registries: ${{ secrets.QA_AWS_ACCOUNT_NUMBER }}