diff --git a/.gitignore b/.gitignore
index 64d811d4bed..ab2dd6a91bb 100644
--- a/.gitignore
+++ b/.gitignore
@@ -71,6 +71,7 @@ lib/tbb
 
 # local make include
 /make/local
+/make/ucrt
 
 # python byte code
 *.pyc
diff --git a/make/compiler_flags b/make/compiler_flags
index 1552381f232..a4c6224e6da 100644
--- a/make/compiler_flags
+++ b/make/compiler_flags
@@ -161,6 +161,21 @@ ifeq ($(OS),Windows_NT)
     CXXFLAGS_OS ?= -m64
   endif
 
+  make/ucrt:
+    pound := \#
+    UCRT_STRING := $(shell echo '$(pound)include <windows.h>' | $(CXX) -E -dM -  | findstr _UCRT)
+    ifneq (,$(UCRT_STRING))
+      IS_UCRT ?= true
+    else
+      IS_UCRT ?= false
+    endif
+    $(shell echo "IS_UCRT ?= $(IS_UCRT)" > $(MATH)make/ucrt)
+
+  include make/ucrt
+  ifeq ($(IS_UCRT),true)
+    CXXFLAGS_OS += -D_UCRT
+  endif
+
   ifneq (gcc,$(CXX_TYPE))
     LDLIBS_OS ?= -static-libgcc
   else
diff --git a/make/libraries b/make/libraries
index 441f5b8c3e0..7dd5dcbfd45 100644
--- a/make/libraries
+++ b/make/libraries
@@ -139,6 +139,12 @@ ifeq (Linux, $(OS))
   SHELL = /usr/bin/env bash
 endif
 
+ifeq (Windows_NT, $(OS))
+  ifeq ($(IS_UCRT),true)
+    TBB_CXXFLAGS += -D_UCRT
+  endif
+endif
+
 # If brackets or spaces are found in MAKE on Windows
 # we error, as those characters cause issues when building.
 ifeq (Windows_NT, $(OS))
diff --git a/make/tests b/make/tests
index 14a2550f08d..fcf379d6520 100644
--- a/make/tests
+++ b/make/tests
@@ -101,12 +101,15 @@ HEADER_TESTS := $(addsuffix -test,$(call findfiles,stan,*.hpp))
 
 ifeq ($(OS),Windows_NT)
   DEV_NULL = nul
+  ifeq ($(IS_UCRT),true)
+    UCRT_NULL_FLAG = -S
+  endif
 else
   DEV_NULL = /dev/null
 endif
 
 %.hpp-test : %.hpp test/dummy.cpp
-	$(COMPILE.cpp) $(CXXFLAGS) -O0 -include $^ -o $(DEV_NULL) -Wunused-local-typedefs
+	$(COMPILE.cpp) $(CXXFLAGS) -O0 -include $^ $(UCRT_NULL_FLAG) -o $(DEV_NULL) -Wunused-local-typedefs
 
 test/dummy.cpp:
 	@mkdir -p test
diff --git a/makefile b/makefile
index f34da7b164b..f14ab40df4e 100644
--- a/makefile
+++ b/makefile
@@ -125,6 +125,7 @@ clean-deps:
 	@$(RM) $(call findfiles,test,*.d.*)
 	@$(RM) $(call findfiles,lib,*.d.*)
 	@$(RM) $(call findfiles,stan,*.dSYM)
+	@$(RM) $(call findfiles,make,ucrt)
 
 clean-all: clean clean-doxygen clean-deps clean-libraries