clean_data_from_js.json

[
  {
    "groups": [
      {
        "groups": [
          {
            "id": "R-HSA-1221632",
            "label": "Meiotic synapsis",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1221632"
          },
          {
            "id": "R-HSA-912446",
            "label": "Meiotic recombination",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-912446"
          }
        ],
        "id": "R-HSA-1500620",
        "label": "Meiosis",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1500620"
      },
      {
        "groups": [
          {
            "groups": [
              {
                "id": "R-HSA-176187",
                "label": "Activation of ATR in response to replication stress",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-176187"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-75035",
                    "label": "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-75035"
                  }
                ],
                "id": "R-HSA-69473",
                "label": "G2/M DNA damage checkpoint",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69473"
              },
              {
                "id": "R-HSA-69478",
                "label": "G2/M DNA replication checkpoint",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69478"
              }
            ],
            "id": "R-HSA-69481",
            "label": "G2/M Checkpoints",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69481"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "groups": [
                      {
                        "groups": [
                          {
                            "id": "R-HSA-349425",
                            "label": "Autodegradation of the E3 ubiquitin ligase COP1",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-349425"
                          }
                        ],
                        "id": "R-HSA-69541",
                        "label": "Stabilization of p53",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69541"
                      },
                      {
                        "groups": [
                          {
                            "id": "R-HSA-69895",
                            "label": "Transcriptional  activation of  cell cycle inhibitor p21 ",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69895"
                          }
                        ],
                        "id": "R-HSA-69560",
                        "label": "Transcriptional activation of p53 responsive genes  ",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69560"
                      }
                    ],
                    "id": "R-HSA-69563",
                    "label": "p53-Dependent G1 DNA Damage Response",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69563"
                  }
                ],
                "id": "R-HSA-69580",
                "label": "p53-Dependent G1/S DNA damage checkpoint",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69580"
              },
              {
                "groups": [
                  {
                    "groups": [
                      {
                        "id": "R-HSA-69601",
                        "label": "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69601"
                      }
                    ],
                    "id": "R-HSA-69610",
                    "label": "p53-Independent DNA Damage Response",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69610"
                  }
                ],
                "id": "R-HSA-69613",
                "label": "p53-Independent G1/S DNA damage checkpoint",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69613"
              }
            ],
            "id": "R-HSA-69615",
            "label": "G1/S DNA Damage Checkpoints",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69615"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-141430",
                    "label": "Inactivation of APC/C via direct inhibition of the APC/C complex",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-141430"
                  }
                ],
                "id": "R-HSA-141405",
                "label": "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-141405"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-141444",
                    "label": "Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-141444"
                  }
                ],
                "id": "R-HSA-141424",
                "label": "Amplification of signal from the kinetochores",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-141424"
              }
            ],
            "id": "R-HSA-69618",
            "label": "Mitotic Spindle Checkpoint",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69618"
          }
        ],
        "id": "R-HSA-69620",
        "label": "Cell Cycle Checkpoints",
        "weight": 20,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69620"
      },
      {
        "groups": [
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-174084",
                    "label": "Autodegradation of Cdh1 by Cdh1:APC/C",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-174084"
                  },
                  {
                    "id": "R-HSA-174178",
                    "label": "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-174178"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-174113",
                        "label": "SCF-beta-TrCP mediated degradation of Emi1",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-174113"
                      },
                      {
                        "id": "R-HSA-176417",
                        "label": "Phosphorylation of Emi1",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-176417"
                      },
                      {
                        "groups": [
                          {
                            "id": "R-HSA-141430",
                            "label": "Inactivation of APC/C via direct inhibition of the APC/C complex",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-141430"
                          }
                        ],
                        "id": "R-HSA-141405",
                        "label": "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-141405"
                      }
                    ],
                    "id": "R-HSA-176408",
                    "label": "Regulation of APC/C activators between G1/S and early anaphase",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-176408"
                  },
                  {
                    "id": "R-HSA-176407",
                    "label": "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-176407"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-176412",
                        "label": "Phosphorylation of the APC/C",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-176412"
                      },
                      {
                        "groups": [
                          {
                            "id": "R-HSA-174048",
                            "label": "APC/C:Cdc20 mediated degradation of Cyclin B",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-174048"
                          },
                          {
                            "id": "R-HSA-174154",
                            "label": "APC/C:Cdc20 mediated degradation of Securin",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-174154"
                          },
                          {
                            "groups": [
                              {
                                "id": "R-HSA-174184",
                                "label": "Cdc20:Phospho-APC/C mediated degradation of Cyclin A",
                                "weight": 10,
                                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-174184"
                              },
                              {
                                "id": "R-HSA-179409",
                                "label": "APC-Cdc20 mediated degradation of Nek2A",
                                "weight": 9,
                                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-179409"
                              }
                            ],
                            "id": "R-HSA-179419",
                            "label": "APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint",
                            "weight": 10,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-179419"
                          }
                        ],
                        "id": "R-HSA-176409",
                        "label": "APC/C:Cdc20 mediated degradation of mitotic proteins",
                        "weight": 10,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-176409"
                      }
                    ],
                    "id": "R-HSA-176814",
                    "label": "Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-176814"
                  }
                ],
                "id": "R-HSA-174143",
                "label": "APC/C-mediated degradation of cell cycle proteins",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-174143"
              }
            ],
            "id": "R-HSA-453276",
            "label": "Regulation of mitotic cell cycle",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-453276"
          },
          {
            "groups": [
              {
                "id": "R-HSA-68911",
                "label": "G2 Phase",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-68911"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-156711",
                    "label": "Polo-like kinase mediated events",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-156711"
                  },
                  {
                    "groups": [
                      {
                        "groups": [
                          {
                            "id": "R-HSA-380259",
                            "label": "Loss of Nlp from mitotic centrosomes",
                            "weight": 10,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-380259"
                          }
                        ],
                        "id": "R-HSA-380284",
                        "label": "Loss of proteins required for interphase microtubule organization from the centrosome",
                        "weight": 10,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-380284"
                      },
                      {
                        "id": "R-HSA-380270",
                        "label": "Recruitment of mitotic centrosome proteins and complexes",
                        "weight": 10,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-380270"
                      }
                    ],
                    "id": "R-HSA-380287",
                    "label": "Centrosome maturation",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-380287"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-170145",
                        "label": "Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-170145"
                      }
                    ],
                    "id": "R-HSA-69273",
                    "label": "Cyclin A/B1/B2 associated events during G2/M transition",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69273"
                  },
                  {
                    "id": "R-HSA-8852276",
                    "label": "The role of GTSE1 in G2/M progression after G2 checkpoint",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8852276"
                  },
                  {
                    "id": "R-HSA-8854050",
                    "label": "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8854050"
                  },
                  {
                    "id": "R-HSA-8854521",
                    "label": "Interaction between PHLDA1 and AURKA",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8854521"
                  },
                  {
                    "id": "R-HSA-8854518",
                    "label": "AURKA Activation by TPX2",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8854518"
                  },
                  {
                    "id": "R-HSA-2565942",
                    "label": "Regulation of PLK1 Activity at G2/M Transition",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2565942"
                  }
                ],
                "id": "R-HSA-69275",
                "label": "G2/M Transition",
                "weight": 20,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69275"
              }
            ],
            "id": "R-HSA-453274",
            "label": "Mitotic G2-G2/M phases",
            "weight": 20,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-453274"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "groups": [
                      {
                        "id": "R-HSA-113501",
                        "label": "Inhibition of replication initiation of damaged DNA by RB1/E2F1",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-113501"
                      },
                      {
                        "id": "R-HSA-113507",
                        "label": "E2F-enabled inhibition of pre-replication complex formation",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-113507"
                      }
                    ],
                    "id": "R-HSA-113510",
                    "label": "E2F mediated regulation of DNA replication",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-113510"
                  },
                  {
                    "id": "R-HSA-68962",
                    "label": "Activation of the pre-replicative complex",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-68962"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-187577",
                        "label": "SCF(Skp2)-mediated degradation of p27/p21",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-187577"
                      },
                      {
                        "id": "R-HSA-69200",
                        "label": "Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69200"
                      }
                    ],
                    "id": "R-HSA-69202",
                    "label": "Cyclin E associated events during G1/S transition ",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69202"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-539107",
                        "label": "Activation of E2F1 target genes at G1/S",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-539107"
                      }
                    ],
                    "id": "R-HSA-69205",
                    "label": "G1/S-Specific Transcription",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69205"
                  }
                ],
                "id": "R-HSA-69206",
                "label": "G1/S Transition",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69206"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-69231",
                    "label": "Cyclin D associated events in G1",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69231"
                  }
                ],
                "id": "R-HSA-69236",
                "label": "G1 Phase",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69236"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-1362300",
                    "label": "Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1362300"
                  },
                  {
                    "id": "R-HSA-1362277",
                    "label": "Transcription of E2F targets under negative control by DREAM complex",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1362277"
                  }
                ],
                "id": "R-HSA-1538133",
                "label": "G0 and Early G1",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1538133"
              }
            ],
            "id": "R-HSA-453279",
            "label": "Mitotic G1-G1/S phases",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-453279"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-68881",
                    "label": "Mitotic Metaphase/Anaphase Transition",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-68881"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-2467813",
                        "label": "Separation of Sister Chromatids",
                        "weight": 10,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2467813"
                      },
                      {
                        "groups": [
                          {
                            "id": "R-HSA-2995383",
                            "label": "Initiation of Nuclear Envelope Reformation",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2995383"
                          }
                        ],
                        "id": "R-HSA-2995410",
                        "label": "Nuclear Envelope Reassembly",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2995410"
                      }
                    ],
                    "id": "R-HSA-68882",
                    "label": "Mitotic Anaphase",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-68882"
                  }
                ],
                "id": "R-HSA-2555396",
                "label": "Mitotic Metaphase and Anaphase",
                "weight": 20,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2555396"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-162658",
                    "label": "Golgi Cisternae Pericentriolar Stack Reorganization",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-162658"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-3301854",
                        "label": "Nuclear Pore Complex (NPC) Disassembly",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3301854"
                      },
                      {
                        "id": "R-HSA-4419969",
                        "label": "Depolymerisation of the Nuclear Lamina",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4419969"
                      },
                      {
                        "id": "R-HSA-2980767",
                        "label": "Activation of NIMA Kinases NEK9, NEK6, NEK7",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2980767"
                      },
                      {
                        "id": "R-HSA-2993913",
                        "label": "Clearance of Nuclear Envelope Membranes from Chromatin",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2993913"
                      }
                    ],
                    "id": "R-HSA-2980766",
                    "label": "Nuclear Envelope Breakdown",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2980766"
                  },
                  {
                    "id": "R-HSA-2465910",
                    "label": "MASTL Facilitates Mitotic Progression",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2465910"
                  },
                  {
                    "id": "R-HSA-2299718",
                    "label": "Condensation of Prophase Chromosomes",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2299718"
                  }
                ],
                "id": "R-HSA-68875",
                "label": "Mitotic Prophase",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-68875"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-380320",
                    "label": "Recruitment of NuMA to mitotic centrosomes",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-380320"
                  },
                  {
                    "id": "R-HSA-2500257",
                    "label": "Resolution of Sister Chromatid Cohesion",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2500257"
                  },
                  {
                    "id": "R-HSA-2514853",
                    "label": "Condensation of Prometaphase Chromosomes",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2514853"
                  }
                ],
                "id": "R-HSA-68877",
                "label": "Mitotic Prometaphase",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-68877"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-2470946",
                    "label": "Cohesin Loading onto Chromatin",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2470946"
                  }
                ],
                "id": "R-HSA-68884",
                "label": "Mitotic Telophase/Cytokinesis",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-68884"
              }
            ],
            "id": "R-HSA-68886",
            "label": "M Phase",
            "weight": 30,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-68886"
          },
          {
            "groups": [
              {
                "id": "R-HSA-2468052",
                "label": "Establishment of Sister Chromatid Cohesion",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2468052"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-68952",
                    "label": "DNA replication initiation",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-68952"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-68949",
                        "label": "Orc1 removal from chromatin",
                        "weight": 10,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-68949"
                      },
                      {
                        "id": "R-HSA-69017",
                        "label": "CDK-mediated phosphorylation and removal of Cdc6",
                        "weight": 10,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69017"
                      }
                    ],
                    "id": "R-HSA-69052",
                    "label": "Switching of origins to a post-replicative state",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69052"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-176974",
                        "label": "Unwinding of DNA",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-176974"
                      },
                      {
                        "groups": [
                          {
                            "id": "R-HSA-69091",
                            "label": "Polymerase switching",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69091"
                          }
                        ],
                        "id": "R-HSA-69109",
                        "label": "Leading Strand Synthesis",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69109"
                      },
                      {
                        "groups": [
                          {
                            "id": "R-HSA-69091",
                            "label": "Polymerase switching",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69091"
                          },
                          {
                            "groups": [
                              {
                                "id": "R-HSA-69166",
                                "label": "Removal of the Flap Intermediate",
                                "weight": 9,
                                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69166"
                              }
                            ],
                            "id": "R-HSA-69183",
                            "label": "Processive synthesis on the lagging strand",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69183"
                          }
                        ],
                        "id": "R-HSA-69186",
                        "label": "Lagging Strand Synthesis",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69186"
                      }
                    ],
                    "id": "R-HSA-69190",
                    "label": "DNA strand elongation",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69190"
                  }
                ],
                "id": "R-HSA-69239",
                "label": "Synthesis of DNA",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69239"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-187577",
                    "label": "SCF(Skp2)-mediated degradation of p27/p21",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-187577"
                  }
                ],
                "id": "R-HSA-69656",
                "label": "Cyclin A:Cdk2-associated events at S phase entry",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69656"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-69229",
                    "label": "Ubiquitin-dependent degradation of Cyclin D1",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69229"
                  }
                ],
                "id": "R-HSA-75815",
                "label": "Ubiquitin-dependent degradation of Cyclin D",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-75815"
              }
            ],
            "id": "R-HSA-69242",
            "label": "S Phase",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69242"
          }
        ],
        "id": "R-HSA-69278",
        "label": "Cell Cycle, Mitotic",
        "weight": 40,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69278"
      },
      {
        "groups": [
          {
            "groups": [
              {
                "id": "R-HSA-171306",
                "label": "Packaging Of Telomere Ends",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-171306"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-171319",
                    "label": "Telomere Extension By Telomerase",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-171319"
                  },
                  {
                    "groups": [
                      {
                        "groups": [
                          {
                            "id": "R-HSA-174437",
                            "label": "Removal of the Flap Intermediate from the C-strand",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-174437"
                          }
                        ],
                        "id": "R-HSA-174414",
                        "label": "Processive synthesis on the C-strand of the telomere",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-174414"
                      },
                      {
                        "id": "R-HSA-174411",
                        "label": "Polymerase switching on the C-strand of the telomere",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-174411"
                      },
                      {
                        "id": "R-HSA-174430",
                        "label": "Telomere C-strand synthesis initiation",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-174430"
                      }
                    ],
                    "id": "R-HSA-174417",
                    "label": "Telomere C-strand (Lagging Strand) Synthesis",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-174417"
                  }
                ],
                "id": "R-HSA-180786",
                "label": "Extension of Telomeres",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-180786"
              }
            ],
            "id": "R-HSA-157579",
            "label": "Telomere Maintenance",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-157579"
          },
          {
            "groups": [
              {
                "id": "R-HSA-606279",
                "label": "Deposition of new CENPA-containing nucleosomes at the centromere",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-606279"
              }
            ],
            "id": "R-HSA-774815",
            "label": "Nucleosome assembly",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-774815"
          }
        ],
        "id": "R-HSA-73886",
        "label": "Chromosome Maintenance",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-73886"
      }
    ],
    "id": "R-HSA-1640170",
    "label": "Cell Cycle",
    "weight": 50,
    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1640170"
  },
  {
    "groups": [
      {
        "id": "R-HSA-373753",
        "label": "Nephrin family interactions",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-373753"
      },
      {
        "groups": [
          {
            "id": "R-HSA-446107",
            "label": "Type I hemidesmosome assembly",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-446107"
          },
          {
            "groups": [
              {
                "id": "R-HSA-446388",
                "label": "Regulation of cytoskeletal remodeling and cell spreading by IPP complex components",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-446388"
              },
              {
                "id": "R-HSA-446343",
                "label": "Localization of the PINCH-ILK-PARVIN complex to focal adhesions",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-446343"
              }
            ],
            "id": "R-HSA-446353",
            "label": "Cell-extracellular matrix interactions",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-446353"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-420597",
                    "label": "Nectin/Necl  trans heterodimerization",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-420597"
                  }
                ],
                "id": "R-HSA-418990",
                "label": "Adherens junctions interactions",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-418990"
              },
              {
                "id": "R-HSA-420029",
                "label": "Tight junction interactions",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-420029"
              },
              {
                "id": "R-HSA-373756",
                "label": "SDK interactions",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-373756"
              }
            ],
            "id": "R-HSA-421270",
            "label": "Cell-cell junction organization",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-421270"
          }
        ],
        "id": "R-HSA-446728",
        "label": "Cell junction organization",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-446728"
      },
      {
        "id": "R-HSA-391160",
        "label": "Signal regulatory protein family interactions",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-391160"
      }
    ],
    "id": "R-HSA-1500931",
    "label": "Cell-Cell communication",
    "weight": 10,
    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1500931"
  },
  {
    "groups": [
      {
        "id": "R-HSA-1632852",
        "label": "Macroautophagy",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1632852"
      },
      {
        "groups": [
          {
            "id": "R-HSA-5660489",
            "label": "MTF1 activates gene expression",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5660489"
          },
          {
            "id": "R-HSA-5661231",
            "label": "Metallothioneins bind metals",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5661231"
          }
        ],
        "id": "R-HSA-5660526",
        "label": "Response to metal ions",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5660526"
      },
      {
        "groups": [
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-2559584",
                    "label": "Formation of Senescence-Associated Heterochromatin Foci (SAHF)",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2559584"
                  }
                ],
                "id": "R-HSA-2559586",
                "label": "DNA Damage/Telomere Stress Induced Senescence",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2559586"
              },
              {
                "id": "R-HSA-2559585",
                "label": "Oncogene Induced Senescence",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2559585"
              },
              {
                "id": "R-HSA-2559580",
                "label": "Oxidative Stress Induced Senescence",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2559580"
              },
              {
                "id": "R-HSA-2559582",
                "label": "Senescence-Associated Secretory Phenotype (SASP)",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2559582"
              }
            ],
            "id": "R-HSA-2559583",
            "label": "Cellular Senescence",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2559583"
          },
          {
            "id": "R-HSA-3299685",
            "label": "Detoxification of Reactive Oxygen Species",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3299685"
          },
          {
            "groups": [
              {
                "id": "R-HSA-3371511",
                "label": "HSF1 activation",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3371511"
              },
              {
                "id": "R-HSA-3371453",
                "label": "Regulation of HSF1-mediated heat shock response",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3371453"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-3371568",
                    "label": "Attenuation phase",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3371568"
                  }
                ],
                "id": "R-HSA-3371571",
                "label": "HSF1-dependent transactivation",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3371571"
              }
            ],
            "id": "R-HSA-3371556",
            "label": "Cellular response to heat stress",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3371556"
          },
          {
            "id": "R-HSA-3371497",
            "label": "HSP90 chaperone cycle for steroid hormone receptors (SHR)",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3371497"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-1234176",
                    "label": "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1234176"
                  },
                  {
                    "id": "R-HSA-1234158",
                    "label": "Regulation of gene expression by Hypoxia-inducible Factor",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1234158"
                  },
                  {
                    "id": "R-HSA-1234162",
                    "label": "Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1234162"
                  }
                ],
                "id": "R-HSA-1234174",
                "label": "Regulation of Hypoxia-inducible Factor (HIF) by oxygen",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1234174"
              }
            ],
            "id": "R-HSA-2262749",
            "label": "Cellular response to hypoxia",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2262749"
          }
        ],
        "id": "R-HSA-2262752",
        "label": "Cellular responses to stress",
        "weight": 40,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2262752"
      }
    ],
    "id": "R-HSA-8953897",
    "label": "Cellular responses to external stimuli",
    "weight": 40,
    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8953897"
  },
  {
    "groups": [
      {
        "groups": [
          {
            "id": "R-HSA-3214815",
            "label": "HDACs deacetylate histones",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3214815"
          },
          {
            "id": "R-HSA-3214858",
            "label": "RMTs methylate histone arginines",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3214858"
          },
          {
            "id": "R-HSA-3214842",
            "label": "HDMs demethylate histones",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3214842"
          },
          {
            "id": "R-HSA-3214841",
            "label": "PKMTs methylate histone lysines",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3214841"
          },
          {
            "id": "R-HSA-3214847",
            "label": "HATs acetylate histones",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3214847"
          }
        ],
        "id": "R-HSA-3247509",
        "label": "Chromatin modifying enzymes",
        "weight": 20,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3247509"
      }
    ],
    "id": "R-HSA-4839726",
    "label": "Chromatin organization",
    "weight": 20,
    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4839726"
  },
  {
    "groups": [
      {
        "id": "R-HSA-1368108",
        "label": "BMAL1:CLOCK,NPAS2 activates circadian gene expression",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1368108"
      },
      {
        "id": "R-HSA-1368082",
        "label": "RORA activates gene expression",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1368082"
      },
      {
        "id": "R-HSA-1368071",
        "label": "NR1D1 (REV-ERBA) represses gene expression",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1368071"
      }
    ],
    "id": "R-HSA-400253",
    "label": "Circadian Clock",
    "weight": 10,
    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-400253"
  },
  {
    "groups": [
      {
        "id": "R-HSA-381340",
        "label": "Transcriptional regulation of white adipocyte differentiation",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-381340"
      },
      {
        "groups": [
          {
            "id": "R-HSA-6809371",
            "label": "Formation of the cornified envelope",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6809371"
          }
        ],
        "id": "R-HSA-6805567",
        "label": "Keratinization",
        "weight": 20,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6805567"
      },
      {
        "groups": [
          {
            "id": "R-HSA-210747",
            "label": "Regulation of gene expression in early pancreatic precursor cells",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-210747"
          },
          {
            "id": "R-HSA-210746",
            "label": "Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-210746"
          },
          {
            "groups": [
              {
                "id": "R-HSA-211163",
                "label": "AKT-mediated inactivation of FOXO1A",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-211163"
              }
            ],
            "id": "R-HSA-210745",
            "label": "Regulation of gene expression in beta cells",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-210745"
          },
          {
            "id": "R-HSA-210744",
            "label": "Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-210744"
          }
        ],
        "id": "R-HSA-186712",
        "label": "Regulation of beta-cell development",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-186712"
      },
      {
        "groups": [
          {
            "id": "R-HSA-2892245",
            "label": "POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2892245"
          },
          {
            "id": "R-HSA-2892247",
            "label": "POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2892247"
          }
        ],
        "id": "R-HSA-452723",
        "label": "Transcriptional regulation of pluripotent stem cells",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-452723"
      },
      {
        "groups": [
          {
            "id": "R-HSA-1433617",
            "label": "Regulation of signaling by NODAL",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1433617"
          }
        ],
        "id": "R-HSA-1181150",
        "label": "Signaling by NODAL",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1181150"
      },
      {
        "groups": [
          {
            "id": "R-HSA-375170",
            "label": "CDO in myogenesis",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-375170"
          }
        ],
        "id": "R-HSA-525793",
        "label": "Myogenesis",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-525793"
      },
      {
        "groups": [
          {
            "id": "R-HSA-8866376",
            "label": "Reelin signalling pathway",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8866376"
          },
          {
            "groups": [
              {
                "id": "R-HSA-418890",
                "label": "Role of second messengers in netrin-1 signaling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-418890"
              },
              {
                "id": "R-HSA-418886",
                "label": "Netrin mediated repulsion signals",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-418886"
              },
              {
                "id": "R-HSA-418885",
                "label": "DCC mediated attractive signaling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-418885"
              },
              {
                "id": "R-HSA-376172",
                "label": "DSCAM interactions",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-376172"
              }
            ],
            "id": "R-HSA-373752",
            "label": "Netrin-1 signaling",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-373752"
          },
          {
            "groups": [
              {
                "id": "R-HSA-437239",
                "label": "Recycling pathway of L1",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-437239"
              },
              {
                "id": "R-HSA-445095",
                "label": "Interaction between L1 and Ankyrins",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-445095"
              },
              {
                "id": "R-HSA-445144",
                "label": "Signal transduction by L1",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-445144"
              },
              {
                "id": "R-HSA-447038",
                "label": "NrCAM interactions",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-447038"
              },
              {
                "id": "R-HSA-447043",
                "label": "Neurofascin interactions",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-447043"
              },
              {
                "id": "R-HSA-447041",
                "label": "CHL1 interactions",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-447041"
              }
            ],
            "id": "R-HSA-373760",
            "label": "L1CAM interactions",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-373760"
          },
          {
            "groups": [
              {
                "id": "R-HSA-416700",
                "label": "Other semaphorin interactions",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-416700"
              },
              {
                "id": "R-HSA-399954",
                "label": "Sema3A PAK dependent Axon repulsion",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-399954"
              },
              {
                "id": "R-HSA-399955",
                "label": "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-399955"
              },
              {
                "id": "R-HSA-399956",
                "label": "CRMPs in Sema3A signaling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-399956"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-416550",
                    "label": "Sema4D mediated inhibition of cell attachment and migration",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-416550"
                  },
                  {
                    "id": "R-HSA-416572",
                    "label": "Sema4D induced cell migration and growth-cone collapse",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-416572"
                  }
                ],
                "id": "R-HSA-400685",
                "label": "Sema4D in semaphorin signaling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-400685"
              }
            ],
            "id": "R-HSA-373755",
            "label": "Semaphorin interactions",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-373755"
          },
          {
            "groups": [
              {
                "id": "R-HSA-419037",
                "label": "NCAM1 interactions",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-419037"
              }
            ],
            "id": "R-HSA-375165",
            "label": "NCAM signaling for neurite out-growth",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-375165"
          },
          {
            "groups": [
              {
                "id": "R-HSA-8985801",
                "label": "Regulation of cortical dendrite branching",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8985801"
              },
              {
                "id": "R-HSA-8985586",
                "label": "SLIT2:ROBO1 increases RHOA activity",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8985586"
              },
              {
                "id": "R-HSA-9010553",
                "label": "Regulation of expression of SLITs and ROBOs",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9010553"
              },
              {
                "id": "R-HSA-9010642",
                "label": "ROBO receptors bind AKAP5",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9010642"
              },
              {
                "id": "R-HSA-428540",
                "label": "Activation of RAC1",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-428540"
              },
              {
                "id": "R-HSA-428542",
                "label": "Regulation of commissural axon pathfinding by SLIT and ROBO",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-428542"
              },
              {
                "id": "R-HSA-428543",
                "label": "Inactivation of CDC42 and RAC1",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-428543"
              },
              {
                "id": "R-HSA-428890",
                "label": "Role of ABL in ROBO-SLIT signaling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-428890"
              }
            ],
            "id": "R-HSA-376176",
            "label": "Signaling by ROBO receptors",
            "weight": 20,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-376176"
          },
          {
            "groups": [
              {
                "id": "R-HSA-3928662",
                "label": "EPHB-mediated forward signaling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3928662"
              },
              {
                "id": "R-HSA-3928663",
                "label": "EPHA-mediated growth cone collapse",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3928663"
              },
              {
                "id": "R-HSA-3928664",
                "label": "Ephrin signaling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3928664"
              },
              {
                "id": "R-HSA-3928665",
                "label": "EPH-ephrin mediated repulsion of cells",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3928665"
              }
            ],
            "id": "R-HSA-2682334",
            "label": "EPH-Ephrin signaling",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2682334"
          },
          {
            "id": "R-HSA-8853659",
            "label": "RET signaling",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8853659"
          }
        ],
        "id": "R-HSA-422475",
        "label": "Axon guidance",
        "weight": 40,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-422475"
      },
      {
        "id": "R-HSA-5682910",
        "label": "LGI-ADAM interactions",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5682910"
      },
      {
        "groups": [
          {
            "id": "R-HSA-5617472",
            "label": "Activation of anterior HOX genes in hindbrain development during early embryogenesis",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5617472"
          }
        ],
        "id": "R-HSA-5619507",
        "label": "Activation of HOX genes during differentiation",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619507"
      }
    ],
    "id": "R-HSA-1266738",
    "label": "Developmental Biology",
    "weight": 80,
    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1266738"
  },
  {
    "groups": [
      {
        "groups": [
          {
            "id": "R-HSA-192456",
            "label": "Digestion of dietary lipid",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-192456"
          },
          {
            "id": "R-HSA-189085",
            "label": "Digestion of dietary carbohydrate",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-189085"
          }
        ],
        "id": "R-HSA-8935690",
        "label": "Digestion",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8935690"
      },
      {
        "groups": [
          {
            "id": "R-HSA-8981373",
            "label": "Intestinal hexose absorption",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8981373"
          },
          {
            "id": "R-HSA-8963678",
            "label": "Intestinal lipid absorption",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8963678"
          }
        ],
        "id": "R-HSA-8963676",
        "label": "Intestinal absorption",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8963676"
      }
    ],
    "id": "R-HSA-8963743",
    "label": "Digestion and absorption",
    "weight": 10,
    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8963743"
  },
  {
    "groups": [
      {
        "groups": [
          {
            "groups": [
              {
                "id": "R-HSA-5688354",
                "label": "Defective pro-SFTPC causes pulmonary surfactant metabolism dysfunction 2 (SMDP2) and respiratory distress syndrome (RDS)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5688354"
              },
              {
                "id": "R-HSA-5688399",
                "label": "Defective ABCA3 causes pulmonary surfactant metabolism dysfunction 3 (SMDP3)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5688399"
              },
              {
                "id": "R-HSA-5687868",
                "label": "Defective SFTPA2 causes idiopathic pulmonary fibrosis (IPF)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5687868"
              },
              {
                "id": "R-HSA-5688031",
                "label": "Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5688031"
              },
              {
                "id": "R-HSA-5688890",
                "label": "Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5688890"
              },
              {
                "id": "R-HSA-5688849",
                "label": "Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5688849"
              },
              {
                "id": "R-HSA-5687583",
                "label": "Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5687583"
              }
            ],
            "id": "R-HSA-5687613",
            "label": "Diseases associated with surfactant metabolism",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5687613"
          },
          {
            "id": "R-HSA-2160456",
            "label": "Phenylketonuria",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2160456"
          },
          {
            "groups": [
              {
                "id": "R-HSA-5579030",
                "label": "Defective CYP19A1 causes Aromatase excess syndrome (AEXS)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5579030"
              },
              {
                "id": "R-HSA-5579031",
                "label": "Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5579031"
              },
              {
                "id": "R-HSA-5579032",
                "label": "Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5579032"
              },
              {
                "id": "R-HSA-5579002",
                "label": "Defective UGT1A1 causes hyperbilirubinemia",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5579002"
              },
              {
                "id": "R-HSA-5579004",
                "label": "Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5579004"
              },
              {
                "id": "R-HSA-5578997",
                "label": "Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5578997"
              },
              {
                "id": "R-HSA-5578998",
                "label": "Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5578998"
              },
              {
                "id": "R-HSA-5578999",
                "label": "Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5578999"
              },
              {
                "id": "R-HSA-5579000",
                "label": "Defective CYP1B1 causes Glaucoma",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5579000"
              },
              {
                "id": "R-HSA-5579009",
                "label": "Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5579009"
              },
              {
                "id": "R-HSA-5579010",
                "label": "Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5579010"
              },
              {
                "id": "R-HSA-5579011",
                "label": "Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5579011"
              },
              {
                "id": "R-HSA-5579012",
                "label": "Defective MAOA causes Brunner syndrome (BRUNS)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5579012"
              },
              {
                "id": "R-HSA-5579005",
                "label": "Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5579005"
              },
              {
                "id": "R-HSA-5579006",
                "label": "Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5579006"
              },
              {
                "id": "R-HSA-5579007",
                "label": "Defective ACY1 causes encephalopathy",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5579007"
              },
              {
                "id": "R-HSA-5579017",
                "label": "Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5579017"
              },
              {
                "id": "R-HSA-5579019",
                "label": "Defective FMO3 causes Trimethylaminuria (TMAU)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5579019"
              },
              {
                "id": "R-HSA-5579020",
                "label": "Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5579020"
              },
              {
                "id": "R-HSA-5579013",
                "label": "Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5579013"
              },
              {
                "id": "R-HSA-5579014",
                "label": "Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5579014"
              },
              {
                "id": "R-HSA-5579015",
                "label": "Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5579015"
              },
              {
                "id": "R-HSA-5579016",
                "label": "Defective UGT1A4 causes hyperbilirubinemia",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5579016"
              },
              {
                "id": "R-HSA-5579026",
                "label": "Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5579026"
              },
              {
                "id": "R-HSA-5579027",
                "label": "Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5579027"
              },
              {
                "id": "R-HSA-5579028",
                "label": "Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5579028"
              },
              {
                "id": "R-HSA-5579021",
                "label": "Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5579021"
              },
              {
                "id": "R-HSA-5579022",
                "label": "Defective GGT1 causes Glutathionuria (GLUTH)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5579022"
              },
              {
                "id": "R-HSA-5579024",
                "label": "Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5579024"
              },
              {
                "id": "R-HSA-5578995",
                "label": "Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5578995"
              },
              {
                "id": "R-HSA-5578996",
                "label": "Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5578996"
              },
              {
                "id": "R-HSA-9035968",
                "label": "Defective GGT1 causes Glutathionuria (GLUTH)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9035968"
              }
            ],
            "id": "R-HSA-5579029",
            "label": "Metabolic disorders of biological oxidation enzymes",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5579029"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-3371599",
                    "label": "Defective HLCS causes multiple carboxylase deficiency",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3371599"
                  },
                  {
                    "id": "R-HSA-3371598",
                    "label": "Defective BTD causes biotidinase deficiency",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3371598"
                  }
                ],
                "id": "R-HSA-3323169",
                "label": "Defects in biotin (Btn) metabolism",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3323169"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-5683329",
                    "label": "Defective ABCD4 causes methylmalonic aciduria and homocystinuria, cblj type (MAHCJ)",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5683329"
                  },
                  {
                    "id": "R-HSA-3359485",
                    "label": "Defective CD320 causes methylmalonic aciduria",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3359485"
                  },
                  {
                    "id": "R-HSA-3359478",
                    "label": "Defective MUT causes methylmalonic aciduria mut type",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3359478"
                  },
                  {
                    "id": "R-HSA-3359454",
                    "label": "Defective TCN2 causes hereditary megaloblastic anemia",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3359454"
                  },
                  {
                    "id": "R-HSA-3359457",
                    "label": "Defective GIF causes intrinsic factor deficiency",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3359457"
                  },
                  {
                    "id": "R-HSA-3359458",
                    "label": "Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3359458"
                  },
                  {
                    "id": "R-HSA-3359471",
                    "label": "Defective MMAB causes methylmalonic aciduria type cblB",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3359471"
                  },
                  {
                    "id": "R-HSA-3359469",
                    "label": "Defective MTR causes methylmalonic aciduria and homocystinuria type cblG",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3359469"
                  },
                  {
                    "id": "R-HSA-3359475",
                    "label": "Defective MMAA causes methylmalonic aciduria type cblA",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3359475"
                  },
                  {
                    "id": "R-HSA-3359473",
                    "label": "Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3359473"
                  },
                  {
                    "id": "R-HSA-3359474",
                    "label": "Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3359474"
                  },
                  {
                    "id": "R-HSA-3359463",
                    "label": "Defective CUBN causes hereditary megaloblastic anemia 1",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3359463"
                  },
                  {
                    "id": "R-HSA-3359462",
                    "label": "Defective AMN causes hereditary megaloblastic anemia 1",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3359462"
                  },
                  {
                    "id": "R-HSA-3359467",
                    "label": "Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3359467"
                  }
                ],
                "id": "R-HSA-3296469",
                "label": "Defects in cobalamin (B12) metabolism",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3296469"
              }
            ],
            "id": "R-HSA-3296482",
            "label": "Defects in vitamin and cofactor metabolism",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3296482"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-3785653",
                    "label": "Myoclonic epilepsy of Lafora",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3785653"
                  },
                  {
                    "id": "R-HSA-5357609",
                    "label": "Glycogen storage disease type II (GAA)",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5357609"
                  },
                  {
                    "id": "R-HSA-3858516",
                    "label": "Glycogen storage disease type 0 (liver GYS2)",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3858516"
                  },
                  {
                    "id": "R-HSA-3274531",
                    "label": "Glycogen storage disease type Ia (G6PC)",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3274531"
                  },
                  {
                    "id": "R-HSA-3282872",
                    "label": "Severe congenital neutropenia type 4 (G6PC3)",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3282872"
                  },
                  {
                    "id": "R-HSA-3878781",
                    "label": "Glycogen storage disease type IV (GBE1)",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3878781"
                  },
                  {
                    "id": "R-HSA-3814836",
                    "label": "Glycogen storage disease type XV (GYG1)",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3814836"
                  },
                  {
                    "id": "R-HSA-3229133",
                    "label": "Glycogen storage disease type Ib (SLC37A4)",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3229133"
                  },
                  {
                    "id": "R-HSA-3828062",
                    "label": "Glycogen storage disease type 0 (muscle GYS1)",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3828062"
                  }
                ],
                "id": "R-HSA-3229121",
                "label": "Glycogen storage diseases",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3229121"
              },
              {
                "id": "R-HSA-5657560",
                "label": "Hereditary fructose intolerance",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5657560"
              },
              {
                "id": "R-HSA-5657562",
                "label": "Essential fructosuria",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5657562"
              },
              {
                "id": "R-HSA-5662853",
                "label": "Essential pentosuria",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5662853"
              },
              {
                "id": "R-HSA-5659898",
                "label": "Intestinal saccharidase deficiencies",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5659898"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-2206302",
                    "label": "MPS I - Hurler syndrome",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2206302"
                  },
                  {
                    "id": "R-HSA-2206305",
                    "label": "MPS IIID - Sanfilippo syndrome D",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2206305"
                  },
                  {
                    "id": "R-HSA-2206308",
                    "label": "MPS IV - Morquio syndrome B",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2206308"
                  },
                  {
                    "id": "R-HSA-2206307",
                    "label": "MPS IIIA - Sanfilippo syndrome A",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2206307"
                  },
                  {
                    "id": "R-HSA-2206285",
                    "label": "MPS VI - Maroteaux-Lamy syndrome",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2206285"
                  },
                  {
                    "id": "R-HSA-2206282",
                    "label": "MPS IIIB - Sanfilippo syndrome B",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2206282"
                  },
                  {
                    "id": "R-HSA-2206296",
                    "label": "MPS II - Hunter syndrome",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2206296"
                  },
                  {
                    "id": "R-HSA-2206290",
                    "label": "MPS IV - Morquio syndrome A",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2206290"
                  },
                  {
                    "id": "R-HSA-2206292",
                    "label": "MPS VII - Sly syndrome",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2206292"
                  },
                  {
                    "id": "R-HSA-2206291",
                    "label": "MPS IIIC - Sanfilippo syndrome C",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2206291"
                  },
                  {
                    "id": "R-HSA-2206280",
                    "label": "MPS IX - Natowicz syndrome",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2206280"
                  }
                ],
                "id": "R-HSA-2206281",
                "label": "Mucopolysaccharidoses",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2206281"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-6791461",
                    "label": "RPIA deficiency: failed conversion of RU5P to R5P",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6791461"
                  },
                  {
                    "id": "R-HSA-6791462",
                    "label": "TALDO1 deficiency: failed conversion of  Fru(6)P, E4P to SH7P, GA3P",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6791462"
                  },
                  {
                    "id": "R-HSA-6791055",
                    "label": "TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6791055"
                  },
                  {
                    "id": "R-HSA-5659996",
                    "label": "RPIA deficiency: failed conversion of R5P to RU5P",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5659996"
                  }
                ],
                "id": "R-HSA-6791465",
                "label": "Pentose phosphate pathway disease",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6791465"
              }
            ],
            "id": "R-HSA-5663084",
            "label": "Diseases of carbohydrate metabolism",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5663084"
          },
          {
            "id": "R-HSA-2978092",
            "label": "Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2978092"
          }
        ],
        "id": "R-HSA-5668914",
        "label": "Diseases of metabolism",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5668914"
      },
      {
        "groups": [
          {
            "groups": [
              {
                "id": "R-HSA-9608287",
                "label": "Defective MUTYH substrate binding",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9608287"
              },
              {
                "id": "R-HSA-9608290",
                "label": "Defective MUTYH substrate processing",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9608290"
              }
            ],
            "id": "R-HSA-9605310",
            "label": "Defective Base Excision Repair Associated with MUTYH",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9605310"
          }
        ],
        "id": "R-HSA-9605308",
        "label": "Diseases of Base Excision Repair",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9605308"
      },
      {
        "groups": [
          {
            "groups": [
              {
                "id": "R-HSA-3656234",
                "label": "Defective HEXA causes GM2G1",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3656234"
              },
              {
                "id": "R-HSA-3656237",
                "label": "Defective EXT2 causes exostoses 2",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3656237"
              },
              {
                "id": "R-HSA-3656225",
                "label": "Defective CHST6 causes MCDC1",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3656225"
              },
              {
                "id": "R-HSA-3656253",
                "label": "Defective EXT1 causes exostoses 1, TRPS2 and CHDS",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3656253"
              },
              {
                "id": "R-HSA-3656248",
                "label": "Defective HEXB causes GM2G2",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3656248"
              },
              {
                "id": "R-HSA-3656243",
                "label": "Defective ST3GAL3 causes MCT12 and EIEE15",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3656243"
              },
              {
                "id": "R-HSA-3656244",
                "label": "Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3656244"
              },
              {
                "id": "R-HSA-3595177",
                "label": "Defective CHSY1 causes TPBS",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3595177"
              },
              {
                "id": "R-HSA-3595174",
                "label": "Defective CHST14 causes EDS, musculocontractural type",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3595174"
              },
              {
                "id": "R-HSA-3595172",
                "label": "Defective CHST3 causes SEDCJD",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3595172"
              },
              {
                "id": "R-HSA-3560792",
                "label": "Defective SLC26A2 causes chondrodysplasias",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3560792"
              },
              {
                "id": "R-HSA-3560796",
                "label": "Defective PAPSS2 causes SEMD-PA",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3560796"
              },
              {
                "id": "R-HSA-3560783",
                "label": "Defective B4GALT7 causes EDS, progeroid type",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3560783"
              },
              {
                "id": "R-HSA-3560801",
                "label": "Defective B3GAT3 causes JDSSDHD",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3560801"
              },
              {
                "id": "R-HSA-4420332",
                "label": "Defective B3GALT6 causes EDSP2 and SEMDJL1",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4420332"
              }
            ],
            "id": "R-HSA-3560782",
            "label": "Diseases associated with glycosaminoglycan metabolism",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3560782"
          },
          {
            "groups": [
              {
                "id": "R-HSA-5083625",
                "label": "Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5083625"
              },
              {
                "id": "R-HSA-5083632",
                "label": "Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5083632"
              },
              {
                "id": "R-HSA-5083633",
                "label": "Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5083633"
              },
              {
                "id": "R-HSA-5083628",
                "label": "Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5083628"
              },
              {
                "id": "R-HSA-5083627",
                "label": "Defective LARGE causes MDDGA6 and MDDGB6",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5083627"
              },
              {
                "id": "R-HSA-5083630",
                "label": "Defective LFNG causes SCDO3",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5083630"
              },
              {
                "id": "R-HSA-5083629",
                "label": "Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5083629"
              },
              {
                "id": "R-HSA-5083636",
                "label": "Defective GALNT12 causes colorectal cancer 1 (CRCS1)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5083636"
              },
              {
                "id": "R-HSA-5083635",
                "label": "Defective B3GALTL causes Peters-plus syndrome (PpS)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5083635"
              }
            ],
            "id": "R-HSA-3906995",
            "label": "Diseases associated with O-glycosylation of proteins",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3906995"
          },
          {
            "groups": [
              {
                "id": "R-HSA-5609978",
                "label": "Defective GALT can cause Galactosemia",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5609978"
              },
              {
                "id": "R-HSA-5609977",
                "label": "Defective GALE can cause Epimerase-deficiency galactosemia (EDG)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5609977"
              },
              {
                "id": "R-HSA-5609976",
                "label": "Defective GALK1 can cause Galactosemia II (GALCT2)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5609976"
              },
              {
                "id": "R-HSA-5609974",
                "label": "Defective PGM1 causes PGM1-CDG (CDG1t)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5609974"
              },
              {
                "id": "R-HSA-4755609",
                "label": "Defective DHDDS causes retinitis pigmentosa 59",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4755609"
              },
              {
                "id": "R-HSA-4755579",
                "label": "Defective SRD5A3 causes SRD5A3-CDG (CDG-1q) and KHRZ",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4755579"
              },
              {
                "id": "R-HSA-4755583",
                "label": "Defective DOLK causes DOLK-CDG (CDG-1m)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4755583"
              },
              {
                "id": "R-HSA-4043911",
                "label": "Defective PMM2 causes PMM2-CDG (CDG-1a)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4043911"
              },
              {
                "id": "R-HSA-4043916",
                "label": "Defective MPI causes MPI-CDG (CDG-1b)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4043916"
              },
              {
                "id": "R-HSA-4717374",
                "label": "Defective DPM1 causes DPM1-CDG (CDG-1e)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4717374"
              },
              {
                "id": "R-HSA-4719360",
                "label": "Defective DPM3 causes DPM3-CDG (CDG-1o)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4719360"
              },
              {
                "id": "R-HSA-4719377",
                "label": "Defective DPM2 causes DPM2-CDG (CDG-1u)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4719377"
              },
              {
                "id": "R-HSA-4341670",
                "label": "Defective NEU1 causes sialidosis",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4341670"
              },
              {
                "id": "R-HSA-4085023",
                "label": "Defective GFPT1 causes CMSTA1",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4085023"
              },
              {
                "id": "R-HSA-4085011",
                "label": "Defective GNE causes sialuria, Nonaka myopathy and inclusion body myopathy 2",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4085011"
              }
            ],
            "id": "R-HSA-5609975",
            "label": "Diseases associated with glycosylation precursor biosynthesis",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5609975"
          },
          {
            "groups": [
              {
                "id": "R-HSA-4793954",
                "label": "Defective MOGS causes MOGS-CDG (CDG-2b)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4793954"
              },
              {
                "id": "R-HSA-4793952",
                "label": "Defective MGAT2 causes MGAT2-CDG (CDG-2a)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4793952"
              },
              {
                "id": "R-HSA-4793953",
                "label": "Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4793953"
              },
              {
                "id": "R-HSA-4793950",
                "label": "Defective MAN1B1 causes MRT15",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4793950"
              },
              {
                "id": "R-HSA-4549349",
                "label": "Defective ALG2 causes ALG2-CDG (CDG-1i)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4549349"
              },
              {
                "id": "R-HSA-4549356",
                "label": "Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4549356"
              },
              {
                "id": "R-HSA-4549380",
                "label": "Defective ALG1 causes ALG1-CDG (CDG-1k)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4549380"
              },
              {
                "id": "R-HSA-4551295",
                "label": "Defective ALG11 causes ALG11-CDG (CDG-1p)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4551295"
              },
              {
                "id": "R-HSA-4687000",
                "label": "Defective MPDU1 causes MPDU1-CDG (CDG-1f)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4687000"
              },
              {
                "id": "R-HSA-4570571",
                "label": "Defective RFT1 causes RFT1-CDG (CDG-1n)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4570571"
              },
              {
                "id": "R-HSA-5633231",
                "label": "Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5633231"
              },
              {
                "id": "R-HSA-4720489",
                "label": "Defective ALG12 causes ALG12-CDG (CDG-1g)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4720489"
              },
              {
                "id": "R-HSA-4720454",
                "label": "Defective ALG9 causes ALG9-CDG (CDG-1l)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4720454"
              },
              {
                "id": "R-HSA-4720475",
                "label": "Defective ALG3 causes ALG3-CDG (CDG-1d)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4720475"
              },
              {
                "id": "R-HSA-4724325",
                "label": "Defective ALG8 causes ALG8-CDG (CDG-1h)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4724325"
              },
              {
                "id": "R-HSA-4724289",
                "label": "Defective ALG6 causes ALG6-CDG (CDG-1c)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4724289"
              }
            ],
            "id": "R-HSA-3781860",
            "label": "Diseases associated with N-glycosylation of proteins",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3781860"
          }
        ],
        "id": "R-HSA-3781865",
        "label": "Diseases of glycosylation",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3781865"
      },
      {
        "groups": [
          {
            "groups": [
              {
                "id": "R-HSA-3560792",
                "label": "Defective SLC26A2 causes chondrodysplasias",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3560792"
              },
              {
                "id": "R-HSA-5658208",
                "label": "Defective SLC5A2 causes renal glucosuria (GLYS1)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5658208"
              },
              {
                "id": "R-HSA-5658471",
                "label": "Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5658471"
              },
              {
                "id": "R-HSA-5655799",
                "label": "Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5655799"
              },
              {
                "id": "R-HSA-5656364",
                "label": "Defective SLC5A1 causes congenital glucose/galactose malabsorption (GGM)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5656364"
              },
              {
                "id": "R-HSA-5661182",
                "label": "Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5661182"
              },
              {
                "id": "R-HSA-5663020",
                "label": "Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5663020"
              },
              {
                "id": "R-HSA-5659735",
                "label": "Defective SLC6A19 causes Hartnup disorder (HND)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5659735"
              },
              {
                "id": "R-HSA-5659729",
                "label": "Defective SLC6A18 may confer susceptibility to iminoglycinuria and/or hyperglycinuria",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5659729"
              },
              {
                "id": "R-HSA-5660883",
                "label": "Defective SLC7A9 causes cystinuria (CSNU)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5660883"
              },
              {
                "id": "R-HSA-5660862",
                "label": "Defective SLC7A7 causes lysinuric protein intolerance (LPI)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5660862"
              },
              {
                "id": "R-HSA-5660686",
                "label": "Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5660686"
              },
              {
                "id": "R-HSA-5660724",
                "label": "Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5660724"
              },
              {
                "id": "R-HSA-5619092",
                "label": "Defective SLC9A6 causes  X-linked, syndromic mental retardation,, Christianson type (MRXSCH)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619092"
              },
              {
                "id": "R-HSA-5619089",
                "label": "Defective SLC6A5 causes hyperekplexia 3 (HKPX3)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619089"
              },
              {
                "id": "R-HSA-5619088",
                "label": "Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619088"
              },
              {
                "id": "R-HSA-5619087",
                "label": "Defective SLC12A3 causes Gitelman syndrome (GS)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619087"
              },
              {
                "id": "R-HSA-5619101",
                "label": "Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619101"
              },
              {
                "id": "R-HSA-5619099",
                "label": "Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619099"
              },
              {
                "id": "R-HSA-5619098",
                "label": "Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619098"
              },
              {
                "id": "R-HSA-5619097",
                "label": "Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619097"
              },
              {
                "id": "R-HSA-5619096",
                "label": "Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619096"
              },
              {
                "id": "R-HSA-5619095",
                "label": "Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619095"
              },
              {
                "id": "R-HSA-5619094",
                "label": "Variant SLC6A14 may confer susceptibility towards obesity",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619094"
              },
              {
                "id": "R-HSA-5619077",
                "label": "Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619077"
              },
              {
                "id": "R-HSA-5619076",
                "label": "Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619076"
              },
              {
                "id": "R-HSA-5619073",
                "label": "Defective GCK causes maturity-onset diabetes of the young 2 (MODY2)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619073"
              },
              {
                "id": "R-HSA-5619072",
                "label": "Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619072"
              },
              {
                "id": "R-HSA-5619071",
                "label": "Defective SLC22A12 causes renal hypouricemia 1 (RHUC1)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619071"
              },
              {
                "id": "R-HSA-5619070",
                "label": "Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619070"
              },
              {
                "id": "R-HSA-5619085",
                "label": "Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619085"
              },
              {
                "id": "R-HSA-5619083",
                "label": "Defective SLC35A3 causes arthrogryposis, mental retardation, and seizures (AMRS)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619083"
              },
              {
                "id": "R-HSA-5619081",
                "label": "Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619081"
              },
              {
                "id": "R-HSA-5619079",
                "label": "Defective SLC6A18 may confer susceptibility to iminoglycinuria and/or hyperglycinuria",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619079"
              },
              {
                "id": "R-HSA-5619078",
                "label": "Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619078"
              },
              {
                "id": "R-HSA-5619061",
                "label": "Defective SLC33A1 causes spastic paraplegia 42 (SPG42)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619061"
              },
              {
                "id": "R-HSA-5619060",
                "label": "Defective CP causes aceruloplasminemia (ACERULOP)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619060"
              },
              {
                "id": "R-HSA-5619058",
                "label": "Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619058"
              },
              {
                "id": "R-HSA-5619056",
                "label": "Defective HK1 causes hexokinase deficiency (HK deficiency)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619056"
              },
              {
                "id": "R-HSA-5619055",
                "label": "Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619055"
              },
              {
                "id": "R-HSA-5619054",
                "label": "Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619054"
              },
              {
                "id": "R-HSA-5619068",
                "label": "Defective SLC2A10 causes arterial tortuosity syndrome (ATS)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619068"
              },
              {
                "id": "R-HSA-5619067",
                "label": "Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619067"
              },
              {
                "id": "R-HSA-5619066",
                "label": "Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619066"
              },
              {
                "id": "R-HSA-5619063",
                "label": "Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619063"
              },
              {
                "id": "R-HSA-5619062",
                "label": "Defective SLC1A3 causes episodic ataxia 6 (EA6)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619062"
              },
              {
                "id": "R-HSA-5619045",
                "label": "Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619045"
              },
              {
                "id": "R-HSA-5619044",
                "label": "Defective SLC6A19 causes Hartnup disorder (HND)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619044"
              },
              {
                "id": "R-HSA-5619043",
                "label": "Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619043"
              },
              {
                "id": "R-HSA-5619042",
                "label": "Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619042"
              },
              {
                "id": "R-HSA-5619041",
                "label": "Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619041"
              },
              {
                "id": "R-HSA-5619040",
                "label": "Defective SLC34A1 causes hypophosphatemic nephrolithiasis/osteoporosis 1 (NPHLOP1)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619040"
              },
              {
                "id": "R-HSA-5619039",
                "label": "Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619039"
              },
              {
                "id": "R-HSA-5619053",
                "label": "Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619053"
              },
              {
                "id": "R-HSA-5619052",
                "label": "Defective SLC9A9 causes autism 16 (AUTS16)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619052"
              },
              {
                "id": "R-HSA-5619050",
                "label": "Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4),  distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619050"
              },
              {
                "id": "R-HSA-5619049",
                "label": "Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619049"
              },
              {
                "id": "R-HSA-5619048",
                "label": "Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619048"
              },
              {
                "id": "R-HSA-5619047",
                "label": "Defective SLC2A9 causes hypouricemia renal 2 (RHUC2)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619047"
              },
              {
                "id": "R-HSA-5619046",
                "label": "Defective SLC26A4 causes Pendred syndrome (PDS)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619046"
              },
              {
                "id": "R-HSA-5619109",
                "label": "Defective SLC6A2 causes orthostatic intolerance (OI)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619109"
              },
              {
                "id": "R-HSA-5619108",
                "label": "Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619108"
              },
              {
                "id": "R-HSA-5619107",
                "label": "Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619107"
              },
              {
                "id": "R-HSA-5619104",
                "label": "Defective SLC12A1 causes Bartter syndrome 1 (BS1)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619104"
              },
              {
                "id": "R-HSA-5619114",
                "label": "Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619114"
              },
              {
                "id": "R-HSA-5619113",
                "label": "Defective SLC3A1 causes cystinuria (CSNU)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619113"
              },
              {
                "id": "R-HSA-5619111",
                "label": "Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619111"
              },
              {
                "id": "R-HSA-5619110",
                "label": "Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619110"
              },
              {
                "id": "R-HSA-5619037",
                "label": "Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619037"
              },
              {
                "id": "R-HSA-5619036",
                "label": "Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619036"
              },
              {
                "id": "R-HSA-5619035",
                "label": "Defective SLC17A5 causes Salla disease (SD) and ISSD",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619035"
              },
              {
                "id": "R-HSA-9036092",
                "label": "Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9036092"
              }
            ],
            "id": "R-HSA-5619102",
            "label": "SLC transporter disorders",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619102"
          },
          {
            "groups": [
              {
                "id": "R-HSA-5678771",
                "label": "Defective ABCB4 causes progressive familial intrahepatic cholestasis 3, intrahepatic cholestasis of pregnancy 3 and gallbladder disease 1",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5678771"
              },
              {
                "id": "R-HSA-5679001",
                "label": "Defective ABCC2 causes Dubin-Johnson syndrome",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5679001"
              },
              {
                "id": "R-HSA-5679096",
                "label": "Defective ABCG5 causes sitosterolemia",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5679096"
              },
              {
                "id": "R-HSA-5679090",
                "label": "Defective ABCG8 causes gallbladder disease 4 and sitosterolemia",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5679090"
              },
              {
                "id": "R-HSA-5678895",
                "label": "Defective CFTR causes cystic fibrosis",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5678895"
              },
              {
                "id": "R-HSA-5678520",
                "label": "Defective ABCB11 causes progressive familial intrahepatic cholestasis 2 and benign recurrent intrahepatic cholestasis 2",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5678520"
              },
              {
                "id": "R-HSA-5678420",
                "label": "Defective ABCC9 causes dilated cardiomyopathy 10, familial atrial fibrillation 12 and hypertrichotic osteochondrodysplasia",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5678420"
              },
              {
                "id": "R-HSA-5683177",
                "label": "Defective ABCC8 can cause hypoglycemias and hyperglycemias",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5683177"
              },
              {
                "id": "R-HSA-5682294",
                "label": "Defective ABCA12 causes autosomal recessive congenital ichthyosis type 4B",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5682294"
              },
              {
                "id": "R-HSA-5684045",
                "label": "Defective ABCD1 causes adrenoleukodystrophy (ALD)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5684045"
              },
              {
                "id": "R-HSA-5683371",
                "label": "Defective ABCB6 causes isolated colobomatous microphthalmia 7 (MCOPCB7)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5683371"
              },
              {
                "id": "R-HSA-5683329",
                "label": "Defective ABCD4 causes methylmalonic aciduria and homocystinuria, cblj type (MAHCJ)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5683329"
              },
              {
                "id": "R-HSA-5683678",
                "label": "Defective ABCA3 causes pulmonary surfactant metabolism dysfunction type 3 (SMDP3)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5683678"
              },
              {
                "id": "R-HSA-5682113",
                "label": "Defective ABCA1 causes Tangier disease",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5682113"
              },
              {
                "id": "R-HSA-5690338",
                "label": "Defective ABCC6 causes pseudoxanthoma elasticum (PXE)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5690338"
              }
            ],
            "id": "R-HSA-5619084",
            "label": "ABC transporter disorders",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619084"
          }
        ],
        "id": "R-HSA-5619115",
        "label": "Disorders of transmembrane transporters",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5619115"
      },
      {
        "groups": [
          {
            "id": "R-HSA-5545483",
            "label": "Defective Mismatch Repair Associated With MLH1",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5545483"
          },
          {
            "id": "R-HSA-5632987",
            "label": "Defective Mismatch Repair Associated With PMS2",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5632987"
          },
          {
            "id": "R-HSA-5632928",
            "label": "Defective Mismatch Repair Associated With MSH2",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5632928"
          },
          {
            "id": "R-HSA-5632927",
            "label": "Defective Mismatch Repair Associated With MSH3",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5632927"
          },
          {
            "id": "R-HSA-5632968",
            "label": "Defective Mismatch Repair Associated With MSH6",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5632968"
          }
        ],
        "id": "R-HSA-5423599",
        "label": "Diseases of Mismatch Repair (MMR)",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5423599"
      },
      {
        "groups": [
          {
            "id": "R-HSA-8862803",
            "label": "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8862803"
          }
        ],
        "id": "R-HSA-8863678",
        "label": "Neurodegenerative Diseases",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8863678"
      },
      {
        "groups": [
          {
            "groups": [
              {
                "id": "R-HSA-5602680",
                "label": "MyD88 deficiency (TLR5)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5602680"
              },
              {
                "id": "R-HSA-5603041",
                "label": "IRAK4 deficiency (TLR2/4)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5603041"
              },
              {
                "id": "R-HSA-5603037",
                "label": "IRAK4 deficiency (TLR5)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5603037"
              },
              {
                "id": "R-HSA-5603029",
                "label": "IkBA variant leads to EDA-ID",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5603029"
              },
              {
                "id": "R-HSA-5603027",
                "label": "IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5603027"
              },
              {
                "id": "R-HSA-5602415",
                "label": "UNC93B1 deficiency - HSE",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5602415"
              },
              {
                "id": "R-HSA-5602410",
                "label": "TLR3 deficiency - HSE",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5602410"
              },
              {
                "id": "R-HSA-5602571",
                "label": "TRAF3 deficiency - HSE",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5602571"
              },
              {
                "id": "R-HSA-5602566",
                "label": "TICAM1 deficiency - HSE",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5602566"
              },
              {
                "id": "R-HSA-5602636",
                "label": "IKBKB deficiency causes SCID",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5602636"
              },
              {
                "id": "R-HSA-5602498",
                "label": "MyD88 deficiency (TLR2/4)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5602498"
              }
            ],
            "id": "R-HSA-5602358",
            "label": "Diseases associated with the TLR signaling cascade",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5602358"
          }
        ],
        "id": "R-HSA-5260271",
        "label": "Diseases of Immune System",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5260271"
      },
      {
        "groups": [
          {
            "groups": [
              {
                "id": "R-HSA-9022535",
                "label": "Loss of phosphorylation of MECP2 at T308",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9022535"
              },
              {
                "id": "R-HSA-9022538",
                "label": "Loss of MECP2 binding ability to 5mC-DNA",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9022538"
              },
              {
                "id": "R-HSA-9022537",
                "label": "Loss of MECP2 binding ability to the NCoR/SMRT complex",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9022537"
              },
              {
                "id": "R-HSA-9022534",
                "label": "Loss of MECP2 binding ability to 5hmC-DNA",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9022534"
              }
            ],
            "id": "R-HSA-9005891",
            "label": "Loss of function of MECP2 in Rett syndrome",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9005891"
          }
        ],
        "id": "R-HSA-9005895",
        "label": "Pervasive developmental disorders",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9005895"
      },
      {
        "groups": [
          {
            "groups": [
              {
                "id": "R-HSA-5362768",
                "label": "Hh mutants that don't undergo autocatalytic processing are degraded by ERAD",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5362768"
              },
              {
                "id": "R-HSA-5658034",
                "label": "HHAT G278V abrogates palmitoylation of Hh-Np",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5658034"
              }
            ],
            "id": "R-HSA-5387390",
            "label": "Hh mutants abrogate ligand secretion",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5387390"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-2691232",
                    "label": "Constitutive Signaling by NOTCH1 HD Domain Mutants",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2691232"
                  }
                ],
                "id": "R-HSA-2691230",
                "label": "Signaling by NOTCH1 HD Domain Mutants in Cancer",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2691230"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-2894862",
                    "label": "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2894862"
                  }
                ],
                "id": "R-HSA-2894858",
                "label": "Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2894858"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-2644606",
                    "label": "Constitutive Signaling by NOTCH1 PEST Domain Mutants",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2644606"
                  }
                ],
                "id": "R-HSA-2644602",
                "label": "Signaling by NOTCH1 PEST Domain Mutants in Cancer",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2644602"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-2644607",
                    "label": "Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2644607"
                  }
                ],
                "id": "R-HSA-2644605",
                "label": "FBXW7 Mutants and NOTCH1 in Cancer",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2644605"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-2660826",
                    "label": "Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2660826"
                  }
                ],
                "id": "R-HSA-2660825",
                "label": "Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2660825"
              }
            ],
            "id": "R-HSA-2644603",
            "label": "Signaling by NOTCH1 in Cancer",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2644603"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-3311021",
                    "label": "SMAD4 MH2 Domain Mutants in Cancer",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3311021"
                  }
                ],
                "id": "R-HSA-3304347",
                "label": "Loss of Function of SMAD4 in Cancer",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3304347"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-3304356",
                    "label": "SMAD2/3 Phosphorylation Motif Mutants in Cancer",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3304356"
                  },
                  {
                    "id": "R-HSA-3315487",
                    "label": "SMAD2/3 MH2 Domain Mutants in Cancer",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3315487"
                  }
                ],
                "id": "R-HSA-3304349",
                "label": "Loss of Function of SMAD2/3 in Cancer",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3304349"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-3642279",
                    "label": "TGFBR2 MSI Frameshift Mutants in Cancer",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3642279"
                  },
                  {
                    "id": "R-HSA-3645790",
                    "label": "TGFBR2 Kinase Domain Mutants in Cancer",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3645790"
                  }
                ],
                "id": "R-HSA-3642278",
                "label": "Loss of Function of TGFBR2 in Cancer",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3642278"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-3656535",
                    "label": "TGFBR1 LBD Mutants in Cancer",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3656535"
                  },
                  {
                    "id": "R-HSA-3656532",
                    "label": "TGFBR1 KD Mutants in Cancer",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3656532"
                  }
                ],
                "id": "R-HSA-3656534",
                "label": "Loss of Function of TGFBR1 in Cancer",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3656534"
              }
            ],
            "id": "R-HSA-3304351",
            "label": "Signaling by TGF-beta Receptor Complex in Cancer",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3304351"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "groups": [
                      {
                        "id": "R-HSA-8851708",
                        "label": "Signaling by FGFR2 IIIa TM",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8851708"
                      },
                      {
                        "id": "R-HSA-8853333",
                        "label": "Signaling by FGFR2 fusions",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8853333"
                      },
                      {
                        "id": "R-HSA-2023837",
                        "label": "Signaling by FGFR2 amplification mutants",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2023837"
                      },
                      {
                        "id": "R-HSA-2033519",
                        "label": "Activated point mutants of FGFR2",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2033519"
                      }
                    ],
                    "id": "R-HSA-1839126",
                    "label": "FGFR2 mutant receptor activation",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1839126"
                  }
                ],
                "id": "R-HSA-5655253",
                "label": "Signaling by FGFR2 in disease",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5655253"
              },
              {
                "groups": [
                  {
                    "groups": [
                      {
                        "id": "R-HSA-1839117",
                        "label": "Signaling by cytosolic FGFR1 fusion mutants",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1839117"
                      },
                      {
                        "id": "R-HSA-1839122",
                        "label": "Signaling by activated point mutants of FGFR1",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1839122"
                      },
                      {
                        "id": "R-HSA-1839120",
                        "label": "Signaling by FGFR1 amplification mutants",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1839120"
                      },
                      {
                        "id": "R-HSA-8853336",
                        "label": "Signaling by plasma membrane FGFR1 fusions",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8853336"
                      }
                    ],
                    "id": "R-HSA-1839124",
                    "label": "FGFR1 mutant receptor activation",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1839124"
                  }
                ],
                "id": "R-HSA-5655302",
                "label": "Signaling by FGFR1 in disease",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5655302"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-1839128",
                    "label": "FGFR4 mutant receptor activation",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1839128"
                  }
                ],
                "id": "R-HSA-5655291",
                "label": "Signaling by FGFR4 in disease",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5655291"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-8853334",
                    "label": "Signaling by FGFR3 fusions in cancer",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8853334"
                  },
                  {
                    "groups": [
                      {
                        "groups": [
                          {
                            "id": "R-HSA-2033515",
                            "label": "t(4;14) translocations of FGFR3",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2033515"
                          },
                          {
                            "id": "R-HSA-1839130",
                            "label": "Signaling by activated point mutants of FGFR3",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1839130"
                          }
                        ],
                        "id": "R-HSA-2033514",
                        "label": "FGFR3 mutant receptor activation",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2033514"
                      }
                    ],
                    "id": "R-HSA-8853338",
                    "label": "Signaling by FGFR3 point mutants in cancer",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8853338"
                  }
                ],
                "id": "R-HSA-5655332",
                "label": "Signaling by FGFR3 in disease",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5655332"
              }
            ],
            "id": "R-HSA-1226099",
            "label": "Signaling by FGFR in disease",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1226099"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-2466712",
                    "label": "Biosynthesis of A2E, implicated in retinal degradation",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2466712"
                  }
                ],
                "id": "R-HSA-2453864",
                "label": "Retinoid cycle disease events",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2453864"
              },
              {
                "id": "R-HSA-6809583",
                "label": "Retinoid metabolism disease events",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6809583"
              }
            ],
            "id": "R-HSA-2474795",
            "label": "Diseases associated with visual transduction",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2474795"
          },
          {
            "groups": [
              {
                "id": "R-HSA-6802949",
                "label": "Signaling by RAS mutants",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6802949"
              },
              {
                "id": "R-HSA-6802952",
                "label": "Signaling by BRAF and RAF fusions",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6802952"
              },
              {
                "id": "R-HSA-6802953",
                "label": "RAS signaling downstream of NF1 loss-of-function variants",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6802953"
              },
              {
                "id": "R-HSA-6802955",
                "label": "Paradoxical activation of RAF signaling by kinase inactive BRAF",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6802955"
              },
              {
                "id": "R-HSA-6802946",
                "label": "Signaling by moderate kinase activity BRAF mutants",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6802946"
              },
              {
                "id": "R-HSA-6802948",
                "label": "Signaling by high-kinase activity BRAF mutants",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6802948"
              }
            ],
            "id": "R-HSA-6802957",
            "label": "Oncogenic MAPK signaling",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6802957"
          },
          {
            "groups": [
              {
                "id": "R-HSA-5674400",
                "label": "Constitutive Signaling by AKT1 E17K in Cancer",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5674400"
              },
              {
                "id": "R-HSA-5674404",
                "label": "PTEN Loss of Function in Cancer",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5674404"
              },
              {
                "id": "R-HSA-2219530",
                "label": "Constitutive Signaling by Aberrant PI3K in Cancer",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2219530"
              }
            ],
            "id": "R-HSA-2219528",
            "label": "PI3K/AKT Signaling in Cancer",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2219528"
          },
          {
            "groups": [
              {
                "id": "R-HSA-5545619",
                "label": "XAV939 inhibits tankyrase, stabilizing AXIN",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5545619"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-5467340",
                    "label": "AXIN missense mutants destabilize the destruction complex",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5467340"
                  },
                  {
                    "id": "R-HSA-5467345",
                    "label": "Deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5467345"
                  }
                ],
                "id": "R-HSA-4839735",
                "label": "AXIN mutants destabilize the destruction complex, activating WNT signaling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4839735"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-5358752",
                    "label": "T41 mutants of beta-catenin aren't phosphorylated",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5358752"
                  },
                  {
                    "id": "R-HSA-5358751",
                    "label": "S45 mutants of beta-catenin aren't phosphorylated",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5358751"
                  },
                  {
                    "id": "R-HSA-5358749",
                    "label": "S37 mutants of beta-catenin aren't phosphorylated",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5358749"
                  },
                  {
                    "id": "R-HSA-5358747",
                    "label": "S33 mutants of beta-catenin aren't phosphorylated",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5358747"
                  }
                ],
                "id": "R-HSA-4839743",
                "label": "phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4839743"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-5467333",
                    "label": "APC truncation mutants are not K63 polyubiquitinated",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5467333"
                  },
                  {
                    "id": "R-HSA-5467337",
                    "label": "APC truncation mutants have impaired AXIN binding",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5467337"
                  }
                ],
                "id": "R-HSA-4839744",
                "label": "truncated APC mutants destabilize the destruction complex",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4839744"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-5467343",
                    "label": "Deletions in the AMER1 gene destabilize the destruction complex",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5467343"
                  },
                  {
                    "id": "R-HSA-5467348",
                    "label": "Truncations of AMER1 destabilize the destruction complex",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5467348"
                  }
                ],
                "id": "R-HSA-4839748",
                "label": "AMER1 mutants destabilize the destruction complex",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4839748"
              },
              {
                "id": "R-HSA-5339700",
                "label": "TCF7L2 mutants don't bind CTBP",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5339700"
              },
              {
                "id": "R-HSA-5339717",
                "label": "Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5339717"
              },
              {
                "id": "R-HSA-5339716",
                "label": "Misspliced GSK3beta mutants stabilize beta-catenin",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5339716"
              },
              {
                "id": "R-HSA-5340588",
                "label": "RNF mutants show enhanced WNT signaling and proliferation",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5340588"
              },
              {
                "id": "R-HSA-5340573",
                "label": "WNT ligand secretion is abrogated by the PORCN inhibitor LGK974",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5340573"
              }
            ],
            "id": "R-HSA-4791275",
            "label": "Signaling by WNT in cancer",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4791275"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-5638303",
                    "label": "Inhibition of Signaling by Overexpressed EGFR",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5638303"
                  }
                ],
                "id": "R-HSA-5638302",
                "label": "Signaling by Overexpressed Wild-Type EGFR in Cancer",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5638302"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-1236382",
                    "label": "Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1236382"
                  }
                ],
                "id": "R-HSA-5637815",
                "label": "Signaling by Ligand-Responsive EGFR Variants in Cancer",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5637815"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-5637810",
                    "label": "Constitutive Signaling by EGFRvIII",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5637810"
                  }
                ],
                "id": "R-HSA-5637812",
                "label": "Signaling by EGFRvIII in Cancer",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5637812"
              }
            ],
            "id": "R-HSA-1643713",
            "label": "Signaling by EGFR in Cancer",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1643713"
          }
        ],
        "id": "R-HSA-5663202",
        "label": "Diseases of signal transduction",
        "weight": 30,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5663202"
      },
      {
        "groups": [
          {
            "groups": [
              {
                "groups": [
                  {
                    "groups": [
                      {
                        "id": "R-HSA-162588",
                        "label": "Budding and maturation of HIV virion",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-162588"
                      },
                      {
                        "id": "R-HSA-165054",
                        "label": "Rev-mediated nuclear export of HIV RNA",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-165054"
                      },
                      {
                        "groups": [
                          {
                            "id": "R-HSA-167161",
                            "label": "HIV Transcription Initiation",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-167161"
                          },
                          {
                            "id": "R-HSA-167160",
                            "label": "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-167160"
                          },
                          {
                            "id": "R-HSA-167162",
                            "label": "RNA Polymerase II HIV Promoter Escape",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-167162"
                          },
                          {
                            "groups": [
                              {
                                "id": "R-HSA-167242",
                                "label": "Abortive elongation of HIV-1 transcript in the absence of Tat",
                                "weight": 9,
                                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-167242"
                              },
                              {
                                "groups": [
                                  {
                                    "id": "R-HSA-167200",
                                    "label": "Formation of HIV-1 elongation complex containing HIV-1 Tat",
                                    "weight": 9,
                                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-167200"
                                  }
                                ],
                                "id": "R-HSA-167246",
                                "label": "Tat-mediated elongation of the HIV-1 transcript",
                                "weight": 9,
                                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-167246"
                              },
                              {
                                "id": "R-HSA-167158",
                                "label": "Formation of the HIV-1 Early Elongation Complex",
                                "weight": 9,
                                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-167158"
                              }
                            ],
                            "id": "R-HSA-167169",
                            "label": "HIV Transcription Elongation",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-167169"
                          },
                          {
                            "id": "R-HSA-167152",
                            "label": "Formation of HIV elongation complex in the absence of HIV Tat",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-167152"
                          },
                          {
                            "id": "R-HSA-167238",
                            "label": "Pausing and recovery of Tat-mediated HIV elongation",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-167238"
                          },
                          {
                            "id": "R-HSA-167243",
                            "label": "Tat-mediated HIV elongation arrest and recovery",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-167243"
                          },
                          {
                            "id": "R-HSA-167287",
                            "label": "HIV elongation arrest and recovery",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-167287"
                          },
                          {
                            "id": "R-HSA-167290",
                            "label": "Pausing and recovery of HIV elongation",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-167290"
                          }
                        ],
                        "id": "R-HSA-167172",
                        "label": "Transcription of the HIV genome",
                        "weight": 10,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-167172"
                      },
                      {
                        "groups": [
                          {
                            "id": "R-HSA-171286",
                            "label": "Synthesis and processing of ENV and VPU",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-171286"
                          },
                          {
                            "groups": [
                              {
                                "id": "R-HSA-174490",
                                "label": "Membrane binding and targetting of GAG proteins",
                                "weight": 9,
                                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-174490"
                              }
                            ],
                            "id": "R-HSA-174495",
                            "label": "Synthesis And Processing Of GAG, GAGPOL Polyproteins",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-174495"
                          }
                        ],
                        "id": "R-HSA-175474",
                        "label": "Assembly Of The HIV Virion",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-175474"
                      }
                    ],
                    "id": "R-HSA-162599",
                    "label": "Late Phase of HIV Life Cycle",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-162599"
                  },
                  {
                    "groups": [
                      {
                        "groups": [
                          {
                            "id": "R-HSA-164843",
                            "label": "2-LTR circle formation",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-164843"
                          },
                          {
                            "id": "R-HSA-175567",
                            "label": "Integration of viral DNA into host genomic DNA",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-175567"
                          },
                          {
                            "id": "R-HSA-177539",
                            "label": "Autointegration results in viral DNA circles",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-177539"
                          }
                        ],
                        "id": "R-HSA-162592",
                        "label": "Integration of provirus",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-162592"
                      },
                      {
                        "groups": [
                          {
                            "id": "R-HSA-164516",
                            "label": "Minus-strand DNA synthesis",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-164516"
                          },
                          {
                            "id": "R-HSA-164525",
                            "label": "Plus-strand DNA synthesis",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-164525"
                          }
                        ],
                        "id": "R-HSA-162589",
                        "label": "Reverse Transcription of HIV RNA",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-162589"
                      },
                      {
                        "id": "R-HSA-162585",
                        "label": "Uncoating of the HIV Virion",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-162585"
                      },
                      {
                        "id": "R-HSA-173107",
                        "label": "Binding and entry of HIV virion",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-173107"
                      }
                    ],
                    "id": "R-HSA-162594",
                    "label": "Early Phase of HIV Life Cycle",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-162594"
                  }
                ],
                "id": "R-HSA-162587",
                "label": "HIV Life Cycle",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-162587"
              },
              {
                "groups": [
                  {
                    "groups": [
                      {
                        "groups": [
                          {
                            "id": "R-HSA-164939",
                            "label": "Nef mediated downregulation of CD28 cell surface expression",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-164939"
                          },
                          {
                            "id": "R-HSA-164940",
                            "label": "Nef mediated downregulation of MHC class I complex cell surface expression",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-164940"
                          },
                          {
                            "id": "R-HSA-167590",
                            "label": "Nef Mediated CD4 Down-regulation",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-167590"
                          },
                          {
                            "id": "R-HSA-182218",
                            "label": "Nef Mediated CD8 Down-regulation",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-182218"
                          }
                        ],
                        "id": "R-HSA-164938",
                        "label": "Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-164938"
                      },
                      {
                        "id": "R-HSA-164944",
                        "label": "Nef and signal transduction",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-164944"
                      }
                    ],
                    "id": "R-HSA-164952",
                    "label": "The role of Nef in HIV-1 replication and disease pathogenesis",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-164952"
                  },
                  {
                    "id": "R-HSA-176034",
                    "label": "Interactions of Tat with host cellular proteins",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-176034"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-180897",
                        "label": "Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-180897"
                      },
                      {
                        "id": "R-HSA-180910",
                        "label": "Vpr-mediated nuclear import of PICs",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-180910"
                      }
                    ],
                    "id": "R-HSA-176033",
                    "label": "Interactions of Vpr with host cellular proteins",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-176033"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-165054",
                        "label": "Rev-mediated nuclear export of HIV RNA",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-165054"
                      },
                      {
                        "id": "R-HSA-180746",
                        "label": "Nuclear import of Rev protein",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-180746"
                      }
                    ],
                    "id": "R-HSA-177243",
                    "label": "Interactions of Rev with host cellular proteins",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-177243"
                  },
                  {
                    "id": "R-HSA-180534",
                    "label": "Vpu mediated degradation of CD4",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-180534"
                  },
                  {
                    "id": "R-HSA-180585",
                    "label": "Vif-mediated degradation of APOBEC3G",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-180585"
                  },
                  {
                    "id": "R-HSA-180689",
                    "label": "APOBEC3G mediated resistance to HIV-1 infection",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-180689"
                  }
                ],
                "id": "R-HSA-162909",
                "label": "Host Interactions of HIV factors",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-162909"
              }
            ],
            "id": "R-HSA-162906",
            "label": "HIV Infection",
            "weight": 20,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-162906"
          },
          {
            "groups": [
              {
                "id": "R-HSA-5336415",
                "label": "Uptake and function of diphtheria toxin",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5336415"
              },
              {
                "id": "R-HSA-8942233",
                "label": "Intestinal infectious diseases",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8942233"
              },
              {
                "id": "R-HSA-5210891",
                "label": "Uptake and function of anthrax toxins",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5210891"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-5250971",
                    "label": "Toxicity of botulinum toxin type C (BoNT/C)",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5250971"
                  },
                  {
                    "id": "R-HSA-5250968",
                    "label": "Toxicity of botulinum toxin type A (BoNT/A)",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5250968"
                  },
                  {
                    "id": "R-HSA-5250958",
                    "label": "Toxicity of botulinum toxin type B (BoNT/B)",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5250958"
                  },
                  {
                    "id": "R-HSA-5250955",
                    "label": "Toxicity of botulinum toxin type D (BoNT/D)",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5250955"
                  },
                  {
                    "id": "R-HSA-5250992",
                    "label": "Toxicity of botulinum toxin type E (BoNT/E)",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5250992"
                  },
                  {
                    "id": "R-HSA-5250989",
                    "label": "Toxicity of botulinum toxin type G (BoNT/G)",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5250989"
                  },
                  {
                    "id": "R-HSA-5250982",
                    "label": "Toxicity of tetanus toxin (TeNT)",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5250982"
                  },
                  {
                    "id": "R-HSA-5250981",
                    "label": "Toxicity of botulinum toxin type F (BoNT/F)",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5250981"
                  }
                ],
                "id": "R-HSA-168799",
                "label": "Neurotoxicity of clostridium toxins",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-168799"
              }
            ],
            "id": "R-HSA-5339562",
            "label": "Uptake and actions of bacterial toxins",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5339562"
          },
          {
            "groups": [
              {
                "id": "R-HSA-8875360",
                "label": "InlB-mediated entry of Listeria monocytogenes into host cell",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8875360"
              },
              {
                "id": "R-HSA-8876493",
                "label": "InlA-mediated entry of Listeria monocytogenes into host cells",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8876493"
              }
            ],
            "id": "R-HSA-8876384",
            "label": "Listeria monocytogenes entry into host cells",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8876384"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "groups": [
                      {
                        "id": "R-HSA-168325",
                        "label": "Viral Messenger RNA Synthesis",
                        "weight": 10,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-168325"
                      },
                      {
                        "id": "R-HSA-192814",
                        "label": "vRNA Synthesis",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-192814"
                      },
                      {
                        "id": "R-HSA-192905",
                        "label": "vRNP Assembly",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-192905"
                      },
                      {
                        "id": "R-HSA-192823",
                        "label": "Viral mRNA Translation",
                        "weight": 10,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-192823"
                      },
                      {
                        "id": "R-HSA-192869",
                        "label": "cRNA Synthesis",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-192869"
                      }
                    ],
                    "id": "R-HSA-168273",
                    "label": "Influenza Viral RNA Transcription and Replication",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-168273"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-168333",
                        "label": "NEP/NS2 Interacts with the Cellular Export Machinery",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-168333"
                      },
                      {
                        "id": "R-HSA-168330",
                        "label": "Viral RNP Complexes in the Host Cell Nucleus",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-168330"
                      }
                    ],
                    "id": "R-HSA-168274",
                    "label": "Export of Viral Ribonucleoproteins from Nucleus",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-168274"
                  },
                  {
                    "id": "R-HSA-168271",
                    "label": "Transport of Ribonucleoproteins into the Host Nucleus",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-168271"
                  },
                  {
                    "id": "R-HSA-168275",
                    "label": "Entry of Influenza Virion into Host Cell via Endocytosis",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-168275"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-168288",
                        "label": "Fusion of the Influenza Virion to the Host Cell Endosome",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-168288"
                      },
                      {
                        "id": "R-HSA-168336",
                        "label": "Uncoating of the Influenza Virion",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-168336"
                      }
                    ],
                    "id": "R-HSA-168270",
                    "label": "Fusion and Uncoating of the Influenza Virion",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-168270"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-168298",
                        "label": "Release",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-168298"
                      },
                      {
                        "groups": [
                          {
                            "id": "R-HSA-168874",
                            "label": "Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-168874"
                          }
                        ],
                        "id": "R-HSA-168316",
                        "label": "Assembly of Viral Components at the Budding Site",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-168316"
                      },
                      {
                        "id": "R-HSA-168302",
                        "label": "Budding",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-168302"
                      },
                      {
                        "id": "R-HSA-168303",
                        "label": "Packaging of Eight RNA Segments",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-168303"
                      }
                    ],
                    "id": "R-HSA-168268",
                    "label": "Virus Assembly and Release",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-168268"
                  }
                ],
                "id": "R-HSA-168255",
                "label": "Influenza Life Cycle",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-168255"
              },
              {
                "groups": [
                  {
                    "groups": [
                      {
                        "groups": [
                          {
                            "id": "R-HSA-168888",
                            "label": "Inhibition of IFN-beta",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-168888"
                          }
                        ],
                        "id": "R-HSA-168305",
                        "label": "Inhibition of Interferon Synthesis",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-168305"
                      },
                      {
                        "id": "R-HSA-168315",
                        "label": "Inhibition of Host mRNA Processing and RNA Silencing",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-168315"
                      },
                      {
                        "id": "R-HSA-169131",
                        "label": "Inhibition of PKR",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-169131"
                      }
                    ],
                    "id": "R-HSA-168276",
                    "label": "NS1 Mediated Effects on Host Pathways",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-168276"
                  },
                  {
                    "id": "R-HSA-168277",
                    "label": "Influenza Virus Induced Apoptosis",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-168277"
                  }
                ],
                "id": "R-HSA-168253",
                "label": "Host Interactions with Influenza Factors",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-168253"
              }
            ],
            "id": "R-HSA-168254",
            "label": "Influenza Infection",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-168254"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-1222387",
                    "label": "Tolerance of reactive oxygen produced by macrophages",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1222387"
                  },
                  {
                    "id": "R-HSA-1222449",
                    "label": "Mtb iron assimilation by chelation",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1222449"
                  },
                  {
                    "id": "R-HSA-1222538",
                    "label": "Tolerance by Mtb to nitric oxide produced by macrophages",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1222538"
                  },
                  {
                    "id": "R-HSA-1222541",
                    "label": "Cell redox homeostasis",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1222541"
                  }
                ],
                "id": "R-HSA-1222499",
                "label": "Response of Mtb to phagocytosis",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1222499"
              }
            ],
            "id": "R-HSA-1222352",
            "label": "Latent infection of Homo sapiens with Mycobacterium tuberculosis",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1222352"
          }
        ],
        "id": "R-HSA-5663205",
        "label": "Infectious disease",
        "weight": 40,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5663205"
      }
    ],
    "id": "R-HSA-1643685",
    "label": "Disease",
    "weight": 100,
    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1643685"
  },
  {
    "groups": [
      {
        "groups": [
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-110331",
                    "label": "Cleavage of the damaged purine",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-110331"
                  },
                  {
                    "id": "R-HSA-110330",
                    "label": "Recognition and association of DNA glycosylase with site containing an affected purine",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-110330"
                  }
                ],
                "id": "R-HSA-73927",
                "label": "Depurination",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-73927"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-110328",
                    "label": "Recognition and association of DNA glycosylase with site containing an affected pyrimidine",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-110328"
                  },
                  {
                    "id": "R-HSA-110329",
                    "label": "Cleavage of the damaged pyrimidine ",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-110329"
                  }
                ],
                "id": "R-HSA-73928",
                "label": "Depyrimidination",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-73928"
              }
            ],
            "id": "R-HSA-73929",
            "label": "Base-Excision Repair, AP Site Formation",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-73929"
          },
          {
            "groups": [
              {
                "id": "R-HSA-5649702",
                "label": "APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5649702"
              },
              {
                "id": "R-HSA-110357",
                "label": "Displacement of DNA glycosylase by APEX1",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-110357"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-5651801",
                    "label": "PCNA-Dependent Long Patch Base Excision Repair",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5651801"
                  },
                  {
                    "id": "R-HSA-110362",
                    "label": "POLB-Dependent Long Patch Base Excision Repair",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-110362"
                  }
                ],
                "id": "R-HSA-110373",
                "label": "Resolution of AP sites via the multiple-nucleotide patch replacement pathway",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-110373"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-73930",
                    "label": "Abasic sugar-phosphate removal via the single-nucleotide replacement pathway",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-73930"
                  }
                ],
                "id": "R-HSA-110381",
                "label": "Resolution of AP sites via the single-nucleotide replacement pathway",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-110381"
              }
            ],
            "id": "R-HSA-73933",
            "label": "Resolution of Abasic Sites (AP sites)",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-73933"
          }
        ],
        "id": "R-HSA-73884",
        "label": "Base Excision Repair",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-73884"
      },
      {
        "groups": [
          {
            "groups": [
              {
                "id": "R-HSA-5655862",
                "label": "Translesion synthesis by POLK",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5655862"
              },
              {
                "id": "R-HSA-5656169",
                "label": "Termination of translesion DNA synthesis",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5656169"
              },
              {
                "id": "R-HSA-5656121",
                "label": "Translesion synthesis by POLI",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5656121"
              },
              {
                "id": "R-HSA-110320",
                "label": "Translesion Synthesis by POLH",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-110320"
              },
              {
                "id": "R-HSA-110312",
                "label": "Translesion synthesis by REV1",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-110312"
              }
            ],
            "id": "R-HSA-110313",
            "label": "Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-110313"
          },
          {
            "id": "R-HSA-110314",
            "label": "Recognition of DNA damage by PCNA-containing replication complex",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-110314"
          }
        ],
        "id": "R-HSA-73893",
        "label": "DNA Damage Bypass",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-73893"
      },
      {
        "groups": [
          {
            "groups": [
              {
                "id": "R-HSA-112126",
                "label": "ALKBH3 mediated reversal of alkylation damage",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-112126"
              },
              {
                "id": "R-HSA-112122",
                "label": "ALKBH2 mediated reversal of alkylation damage",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-112122"
              }
            ],
            "id": "R-HSA-73943",
            "label": "Reversal of alkylation damage by DNA dioxygenases",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-73943"
          },
          {
            "id": "R-HSA-5657655",
            "label": "MGMT-mediated DNA damage reversal",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5657655"
          }
        ],
        "id": "R-HSA-73942",
        "label": "DNA Damage Reversal",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-73942"
      },
      {
        "id": "R-HSA-6783310",
        "label": "Fanconi Anemia Pathway",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6783310"
      },
      {
        "groups": [
          {
            "id": "R-HSA-5358565",
            "label": "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5358565"
          },
          {
            "id": "R-HSA-5358606",
            "label": "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5358606"
          }
        ],
        "id": "R-HSA-5358508",
        "label": "Mismatch Repair",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5358508"
      },
      {
        "groups": [
          {
            "groups": [
              {
                "id": "R-HSA-5693565",
                "label": "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5693565"
              },
              {
                "id": "R-HSA-5693548",
                "label": "Sensing of DNA Double Strand Breaks",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5693548"
              }
            ],
            "id": "R-HSA-5693606",
            "label": "DNA Double Strand Break Response",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5693606"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-5693607",
                    "label": "Processing of DNA double-strand break ends",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5693607"
                  },
                  {
                    "id": "R-HSA-5685938",
                    "label": "HDR through Single Strand Annealing (SSA)",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5685938"
                  },
                  {
                    "groups": [
                      {
                        "groups": [
                          {
                            "id": "R-HSA-5693616",
                            "label": "Presynaptic phase of homologous DNA pairing and strand exchange",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5693616"
                          }
                        ],
                        "id": "R-HSA-5693579",
                        "label": "Homologous DNA Pairing and Strand Exchange",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5693579"
                      },
                      {
                        "groups": [
                          {
                            "id": "R-HSA-5693568",
                            "label": "Resolution of D-loop Structures through Holliday Junction Intermediates",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5693568"
                          },
                          {
                            "id": "R-HSA-5693554",
                            "label": "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5693554"
                          }
                        ],
                        "id": "R-HSA-5693537",
                        "label": "Resolution of D-Loop Structures",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5693537"
                      }
                    ],
                    "id": "R-HSA-5685942",
                    "label": "HDR through Homologous Recombination (HRR)",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5685942"
                  }
                ],
                "id": "R-HSA-5693567",
                "label": "HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5693567"
              },
              {
                "id": "R-HSA-5685939",
                "label": "HDR through MMEJ (alt-NHEJ)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5685939"
              }
            ],
            "id": "R-HSA-5693538",
            "label": "Homology Directed Repair",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5693538"
          },
          {
            "id": "R-HSA-5693571",
            "label": "Nonhomologous End-Joining (NHEJ)",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5693571"
          }
        ],
        "id": "R-HSA-5693532",
        "label": "DNA Double-Strand Break Repair",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5693532"
      },
      {
        "groups": [
          {
            "groups": [
              {
                "id": "R-HSA-6781823",
                "label": "Formation of TC-NER Pre-Incision Complex",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6781823"
              },
              {
                "id": "R-HSA-6782210",
                "label": "Gap-filling DNA repair synthesis and ligation in TC-NER",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6782210"
              },
              {
                "id": "R-HSA-6782135",
                "label": "Dual incision in TC-NER",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6782135"
              }
            ],
            "id": "R-HSA-6781827",
            "label": "Transcription-Coupled Nucleotide Excision Repair (TC-NER)",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6781827"
          },
          {
            "groups": [
              {
                "id": "R-HSA-5696395",
                "label": "Formation of Incision Complex in GG-NER",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5696395"
              },
              {
                "id": "R-HSA-5696397",
                "label": "Gap-filling DNA repair synthesis and ligation in GG-NER",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5696397"
              },
              {
                "id": "R-HSA-5696394",
                "label": "DNA Damage Recognition in GG-NER",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5696394"
              },
              {
                "id": "R-HSA-5696400",
                "label": "Dual Incision in GG-NER",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5696400"
              }
            ],
            "id": "R-HSA-5696399",
            "label": "Global Genome Nucleotide Excision Repair (GG-NER)",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5696399"
          }
        ],
        "id": "R-HSA-5696398",
        "label": "Nucleotide Excision Repair",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5696398"
      }
    ],
    "id": "R-HSA-73894",
    "label": "DNA Repair",
    "weight": 20,
    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-73894"
  },
  {
    "groups": [
      {
        "groups": [
          {
            "groups": [
              {
                "id": "R-HSA-68616",
                "label": "Assembly of the ORC complex at the origin of replication",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-68616"
              },
              {
                "id": "R-HSA-68689",
                "label": "CDC6 association with the ORC:origin complex",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-68689"
              },
              {
                "id": "R-HSA-68827",
                "label": "CDT1 association with the CDC6:ORC:origin complex",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-68827"
              }
            ],
            "id": "R-HSA-68867",
            "label": "Assembly of the pre-replicative complex",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-68867"
          },
          {
            "id": "R-HSA-68962",
            "label": "Activation of the pre-replicative complex",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-68962"
          }
        ],
        "id": "R-HSA-69002",
        "label": "DNA Replication Pre-Initiation",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69002"
      },
      {
        "groups": [
          {
            "id": "R-HSA-68952",
            "label": "DNA replication initiation",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-68952"
          },
          {
            "groups": [
              {
                "id": "R-HSA-68949",
                "label": "Orc1 removal from chromatin",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-68949"
              },
              {
                "id": "R-HSA-69017",
                "label": "CDK-mediated phosphorylation and removal of Cdc6",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69017"
              }
            ],
            "id": "R-HSA-69052",
            "label": "Switching of origins to a post-replicative state",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69052"
          },
          {
            "groups": [
              {
                "id": "R-HSA-176974",
                "label": "Unwinding of DNA",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-176974"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-69091",
                    "label": "Polymerase switching",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69091"
                  }
                ],
                "id": "R-HSA-69109",
                "label": "Leading Strand Synthesis",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69109"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-69091",
                    "label": "Polymerase switching",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69091"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-69166",
                        "label": "Removal of the Flap Intermediate",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69166"
                      }
                    ],
                    "id": "R-HSA-69183",
                    "label": "Processive synthesis on the lagging strand",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69183"
                  }
                ],
                "id": "R-HSA-69186",
                "label": "Lagging Strand Synthesis",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69186"
              }
            ],
            "id": "R-HSA-69190",
            "label": "DNA strand elongation",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69190"
          }
        ],
        "id": "R-HSA-69239",
        "label": "Synthesis of DNA",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69239"
      }
    ],
    "id": "R-HSA-69306",
    "label": "DNA Replication",
    "weight": 10,
    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69306"
  },
  {
    "groups": [
      {
        "groups": [
          {
            "id": "R-HSA-3000170",
            "label": "Syndecan interactions",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3000170"
          }
        ],
        "id": "R-HSA-3000171",
        "label": "Non-integrin membrane-ECM interactions",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3000171"
      },
      {
        "id": "R-HSA-3000178",
        "label": "ECM proteoglycans",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3000178"
      },
      {
        "id": "R-HSA-3000157",
        "label": "Laminin interactions",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3000157"
      },
      {
        "id": "R-HSA-1566977",
        "label": "Fibronectin matrix formation",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1566977"
      },
      {
        "groups": [
          {
            "id": "R-HSA-2129379",
            "label": "Molecules associated with elastic fibres",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2129379"
          }
        ],
        "id": "R-HSA-1566948",
        "label": "Elastic fibre formation",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1566948"
      },
      {
        "id": "R-HSA-216083",
        "label": "Integrin cell surface interactions",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-216083"
      },
      {
        "id": "R-HSA-8941237",
        "label": "Invadopodia formation",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8941237"
      },
      {
        "groups": [
          {
            "groups": [
              {
                "id": "R-HSA-2214320",
                "label": "Anchoring fibril formation",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2214320"
              },
              {
                "id": "R-HSA-2243919",
                "label": "Crosslinking of collagen fibrils",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2243919"
              }
            ],
            "id": "R-HSA-2022090",
            "label": "Assembly of collagen fibrils and other multimeric structures",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2022090"
          },
          {
            "groups": [
              {
                "id": "R-HSA-8948216",
                "label": "Collagen chain trimerization",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8948216"
              }
            ],
            "id": "R-HSA-1650814",
            "label": "Collagen biosynthesis and modifying enzymes",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1650814"
          }
        ],
        "id": "R-HSA-1474290",
        "label": "Collagen formation",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1474290"
      },
      {
        "groups": [
          {
            "id": "R-HSA-1442490",
            "label": "Collagen degradation",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1442490"
          },
          {
            "id": "R-HSA-1592389",
            "label": "Activation of Matrix Metalloproteinases",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1592389"
          }
        ],
        "id": "R-HSA-1474228",
        "label": "Degradation of the extracellular matrix",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1474228"
      }
    ],
    "id": "R-HSA-1474244",
    "label": "Extracellular matrix organization",
    "weight": 20,
    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1474244"
  },
  {
    "groups": [
      {
        "groups": [
          {
            "id": "R-HSA-73779",
            "label": "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-73779"
          },
          {
            "groups": [
              {
                "id": "R-HSA-109688",
                "label": "Cleavage of Growing Transcript in the Termination Region ",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-109688"
              }
            ],
            "id": "R-HSA-73856",
            "label": "RNA Polymerase II Transcription Termination",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-73856"
          },
          {
            "groups": [
              {
                "id": "R-HSA-112382",
                "label": "Formation of RNA Pol II elongation complex ",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-112382"
              },
              {
                "id": "R-HSA-113418",
                "label": "Formation of the Early Elongation Complex",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-113418"
              }
            ],
            "id": "R-HSA-75955",
            "label": "RNA Polymerase II Transcription Elongation",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-75955"
          },
          {
            "groups": [
              {
                "id": "R-HSA-73776",
                "label": "RNA Polymerase II Promoter Escape",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-73776"
              },
              {
                "id": "R-HSA-75953",
                "label": "RNA Polymerase II Transcription Initiation",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-75953"
              }
            ],
            "id": "R-HSA-76042",
            "label": "RNA Polymerase II Transcription Initiation And Promoter Clearance",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-76042"
          },
          {
            "id": "R-HSA-77075",
            "label": "RNA Pol II CTD phosphorylation and interaction with CE",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-77075"
          },
          {
            "groups": [
              {
                "id": "R-HSA-8953750",
                "label": "Transcriptional Regulation by E2F6",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8953750"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-9614657",
                    "label": "FOXO-mediated transcription of cell death genes",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9614657"
                  },
                  {
                    "id": "R-HSA-9614399",
                    "label": "Regulation of localization of FOXO transcription factors",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9614399"
                  },
                  {
                    "id": "R-HSA-9615017",
                    "label": "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9615017"
                  },
                  {
                    "id": "R-HSA-9617629",
                    "label": "Regulation of FOXO transcriptional activity by acetylation",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9617629"
                  },
                  {
                    "id": "R-HSA-9617828",
                    "label": "FOXO-mediated transcription of cell cycle genes",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9617828"
                  }
                ],
                "id": "R-HSA-9614085",
                "label": "FOXO-mediated transcription",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9614085"
              },
              {
                "id": "R-HSA-383280",
                "label": "Nuclear Receptor transcription pathway",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-383280"
              },
              {
                "id": "R-HSA-2032785",
                "label": "YAP1- and WWTR1 (TAZ)-stimulated gene expression",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2032785"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-9022692",
                    "label": "Regulation of MECP2 expression and activity",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9022692"
                  },
                  {
                    "id": "R-HSA-9022702",
                    "label": "MECP2 regulates transcription of neuronal ligands",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9022702"
                  },
                  {
                    "id": "R-HSA-9022699",
                    "label": "MECP2 regulates neuronal receptors and channels",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9022699"
                  },
                  {
                    "id": "R-HSA-9022707",
                    "label": "MECP2 regulates transcription factors",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9022707"
                  },
                  {
                    "id": "R-HSA-9022927",
                    "label": "MECP2 regulates transcription of genes involved in GABA signaling",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9022927"
                  }
                ],
                "id": "R-HSA-8986944",
                "label": "Transcriptional Regulation by MECP2",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8986944"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-2173796",
                    "label": "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2173796"
                  },
                  {
                    "id": "R-HSA-2173795",
                    "label": "Downregulation of SMAD2/3:SMAD4 transcriptional activity",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2173795"
                  }
                ],
                "id": "R-HSA-2173793",
                "label": "Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2173793"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-8869496",
                    "label": "TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8869496"
                  },
                  {
                    "id": "R-HSA-8866910",
                    "label": "TFAP2 (AP-2) family regulates transcription of growth factors and their receptors",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8866910"
                  },
                  {
                    "id": "R-HSA-8866911",
                    "label": "TFAP2 (AP-2) family regulates transcription of cell cycle factors",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8866911"
                  },
                  {
                    "id": "R-HSA-8866904",
                    "label": "Negative regulation of activity of TFAP2 (AP-2) family transcription factors",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8866904"
                  },
                  {
                    "id": "R-HSA-8866906",
                    "label": "TFAP2 (AP-2) family regulates transcription of other transcription factors",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8866906"
                  },
                  {
                    "id": "R-HSA-8866907",
                    "label": "Activation of the TFAP2 (AP-2) family of transcription factors",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8866907"
                  }
                ],
                "id": "R-HSA-8864260",
                "label": "Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8864260"
              },
              {
                "id": "R-HSA-350054",
                "label": "Notch-HLH transcription pathway",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-350054"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-8949275",
                    "label": "RUNX3 Regulates Immune Response and Cell Migration",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8949275"
                  },
                  {
                    "id": "R-HSA-8941855",
                    "label": "RUNX3 regulates CDKN1A transcription",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8941855"
                  },
                  {
                    "id": "R-HSA-8941856",
                    "label": "RUNX3 regulates NOTCH signaling",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8941856"
                  },
                  {
                    "id": "R-HSA-8941858",
                    "label": "Regulation of RUNX3 expression and activity",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8941858"
                  },
                  {
                    "id": "R-HSA-8951430",
                    "label": "RUNX3 regulates WNT signaling",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8951430"
                  },
                  {
                    "id": "R-HSA-8951911",
                    "label": "RUNX3 regulates RUNX1-mediated transcription",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8951911"
                  },
                  {
                    "id": "R-HSA-8951671",
                    "label": "RUNX3 regulates YAP1-mediated transcription",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8951671"
                  },
                  {
                    "id": "R-HSA-8952158",
                    "label": "RUNX3 regulates BCL2L11 (BIM) transcription",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8952158"
                  },
                  {
                    "id": "R-HSA-8951936",
                    "label": "RUNX3 regulates p14-ARF",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8951936"
                  }
                ],
                "id": "R-HSA-8878159",
                "label": "Transcriptional regulation by RUNX3",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8878159"
              },
              {
                "groups": [
                  {
                    "groups": [
                      {
                        "id": "R-HSA-6804116",
                        "label": "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6804116"
                      },
                      {
                        "id": "R-HSA-6804114",
                        "label": "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6804114"
                      },
                      {
                        "id": "R-HSA-6804115",
                        "label": "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6804115"
                      }
                    ],
                    "id": "R-HSA-6791312",
                    "label": "TP53 Regulates Transcription of Cell Cycle Genes",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6791312"
                  },
                  {
                    "id": "R-HSA-6796648",
                    "label": "TP53 Regulates Transcription of DNA Repair Genes",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6796648"
                  },
                  {
                    "id": "R-HSA-5628897",
                    "label": "TP53 Regulates Metabolic Genes",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5628897"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-6804756",
                        "label": "Regulation of TP53 Activity through Phosphorylation",
                        "weight": 10,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6804756"
                      },
                      {
                        "groups": [
                          {
                            "id": "R-HSA-6811555",
                            "label": "PI5P Regulates TP53 Acetylation",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6811555"
                          }
                        ],
                        "id": "R-HSA-6804758",
                        "label": "Regulation of TP53 Activity through Acetylation",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6804758"
                      },
                      {
                        "id": "R-HSA-6804759",
                        "label": "Regulation of TP53 Activity through Association with Co-factors",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6804759"
                      },
                      {
                        "id": "R-HSA-6804760",
                        "label": "Regulation of TP53 Activity through Methylation",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6804760"
                      },
                      {
                        "groups": [
                          {
                            "id": "R-HSA-6804757",
                            "label": "Regulation of TP53 Degradation",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6804757"
                          },
                          {
                            "id": "R-HSA-6804754",
                            "label": "Regulation of TP53 Expression",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6804754"
                          }
                        ],
                        "id": "R-HSA-6806003",
                        "label": "Regulation of TP53 Expression and Degradation",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6806003"
                      }
                    ],
                    "id": "R-HSA-5633007",
                    "label": "Regulation of TP53 Activity",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5633007"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-6803204",
                        "label": "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6803204"
                      },
                      {
                        "id": "R-HSA-6803205",
                        "label": "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6803205"
                      },
                      {
                        "id": "R-HSA-6803207",
                        "label": "TP53 Regulates Transcription of Caspase Activators and Caspases",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6803207"
                      },
                      {
                        "id": "R-HSA-6803211",
                        "label": "TP53 Regulates Transcription of Death Receptors and Ligands",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6803211"
                      }
                    ],
                    "id": "R-HSA-5633008",
                    "label": "TP53 Regulates Transcription of Cell Death Genes",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5633008"
                  }
                ],
                "id": "R-HSA-3700989",
                "label": "Transcriptional Regulation by TP53",
                "weight": 30,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3700989"
              },
              {
                "groups": [
                  {
                    "groups": [
                      {
                        "id": "R-HSA-8941284",
                        "label": "RUNX2 regulates chondrocyte maturation",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8941284"
                      },
                      {
                        "id": "R-HSA-8940973",
                        "label": "RUNX2 regulates osteoblast differentiation",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8940973"
                      }
                    ],
                    "id": "R-HSA-8941326",
                    "label": "RUNX2 regulates bone development",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8941326"
                  },
                  {
                    "id": "R-HSA-8941332",
                    "label": "RUNX2 regulates genes involved in cell migration",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8941332"
                  },
                  {
                    "id": "R-HSA-8941333",
                    "label": "RUNX2 regulates genes involved in differentiation of myeloid cells",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8941333"
                  },
                  {
                    "id": "R-HSA-8939902",
                    "label": "Regulation of RUNX2 expression and activity",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8939902"
                  }
                ],
                "id": "R-HSA-8878166",
                "label": "Transcriptional regulation by RUNX2",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8878166"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-8877330",
                    "label": "RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8877330"
                  },
                  {
                    "id": "R-HSA-8931987",
                    "label": "RUNX1 regulates estrogen receptor mediated transcription",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8931987"
                  },
                  {
                    "id": "R-HSA-8939242",
                    "label": "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8939242"
                  },
                  {
                    "id": "R-HSA-8939236",
                    "label": "RUNX1 regulates transcription of genes involved in differentiation of HSCs",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8939236"
                  },
                  {
                    "id": "R-HSA-8939256",
                    "label": "RUNX1 regulates transcription of genes involved in WNT signaling",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8939256"
                  },
                  {
                    "id": "R-HSA-8939247",
                    "label": "RUNX1 regulates transcription of genes involved in interleukin signaling",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8939247"
                  },
                  {
                    "id": "R-HSA-8939246",
                    "label": "RUNX1 regulates transcription of genes involved in differentiation of myeloid cells",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8939246"
                  },
                  {
                    "id": "R-HSA-8939245",
                    "label": "RUNX1 regulates transcription of genes involved in BCR signaling",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8939245"
                  },
                  {
                    "id": "R-HSA-8939243",
                    "label": "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8939243"
                  },
                  {
                    "id": "R-HSA-8934593",
                    "label": "Regulation of RUNX1 Expression and Activity",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8934593"
                  },
                  {
                    "id": "R-HSA-8935964",
                    "label": "RUNX1 regulates expression of components of tight junctions",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8935964"
                  },
                  {
                    "id": "R-HSA-8936459",
                    "label": "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8936459"
                  }
                ],
                "id": "R-HSA-8878171",
                "label": "Transcriptional regulation by RUNX1",
                "weight": 20,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8878171"
              }
            ],
            "id": "R-HSA-212436",
            "label": "Generic Transcription Pathway",
            "weight": 110,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-212436"
          },
          {
            "id": "R-HSA-674695",
            "label": "RNA Polymerase II Pre-transcription Events",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-674695"
          },
          {
            "id": "R-HSA-6807505",
            "label": "RNA polymerase II transcribes snRNA genes",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6807505"
          }
        ],
        "id": "R-HSA-73857",
        "label": "RNA Polymerase II Transcription",
        "weight": 120,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-73857"
      },
      {
        "groups": [
          {
            "id": "R-HSA-73777",
            "label": "RNA Polymerase I Chain Elongation",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-73777"
          },
          {
            "groups": [
              {
                "id": "R-HSA-73762",
                "label": "RNA Polymerase I Transcription Initiation",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-73762"
              },
              {
                "id": "R-HSA-73772",
                "label": "RNA Polymerase I Promoter Escape",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-73772"
              },
              {
                "id": "R-HSA-73728",
                "label": "RNA Polymerase I Promoter Opening",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-73728"
              }
            ],
            "id": "R-HSA-73854",
            "label": "RNA Polymerase I Promoter Clearance",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-73854"
          },
          {
            "id": "R-HSA-73863",
            "label": "RNA Polymerase I Transcription Termination",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-73863"
          }
        ],
        "id": "R-HSA-73864",
        "label": "RNA Polymerase I Transcription",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-73864"
      },
      {
        "groups": [
          {
            "id": "R-HSA-73780",
            "label": "RNA Polymerase III Chain Elongation",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-73780"
          },
          {
            "id": "R-HSA-73980",
            "label": "RNA Polymerase III Transcription Termination",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-73980"
          },
          {
            "groups": [
              {
                "id": "R-HSA-76061",
                "label": "RNA Polymerase III Transcription Initiation From Type 1 Promoter",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-76061"
              },
              {
                "id": "R-HSA-76066",
                "label": "RNA Polymerase III Transcription Initiation From Type 2 Promoter",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-76066"
              },
              {
                "id": "R-HSA-76071",
                "label": "RNA Polymerase III Transcription Initiation From Type 3 Promoter",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-76071"
              }
            ],
            "id": "R-HSA-76046",
            "label": "RNA Polymerase III Transcription Initiation",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-76046"
          },
          {
            "id": "R-HSA-749476",
            "label": "RNA Polymerase III Abortive And Retractive Initiation",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-749476"
          }
        ],
        "id": "R-HSA-74158",
        "label": "RNA Polymerase III Transcription",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-74158"
      },
      {
        "groups": [
          {
            "id": "R-HSA-163282",
            "label": "Mitochondrial transcription initiation",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-163282"
          },
          {
            "id": "R-HSA-163316",
            "label": "Mitochondrial transcription termination",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-163316"
          }
        ],
        "id": "R-HSA-75944",
        "label": "Transcription from mitochondrial promoters",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-75944"
      },
      {
        "groups": [
          {
            "id": "R-HSA-5601884",
            "label": "PIWI-interacting RNA (piRNA) biogenesis",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5601884"
          },
          {
            "id": "R-HSA-426496",
            "label": "Post-transcriptional silencing by small RNAs",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-426496"
          },
          {
            "id": "R-HSA-426486",
            "label": "Small interfering RNA (siRNA) biogenesis",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-426486"
          },
          {
            "id": "R-HSA-203927",
            "label": "MicroRNA (miRNA) biogenesis",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-203927"
          },
          {
            "id": "R-HSA-5578749",
            "label": "Transcriptional regulation by small RNAs",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5578749"
          }
        ],
        "id": "R-HSA-211000",
        "label": "Gene Silencing by RNA",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-211000"
      },
      {
        "groups": [
          {
            "id": "R-HSA-5221030",
            "label": "TET1,2,3 and TDG demethylate DNA",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5221030"
          },
          {
            "groups": [
              {
                "id": "R-HSA-427389",
                "label": "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-427389"
              },
              {
                "id": "R-HSA-5250924",
                "label": "B-WICH complex positively regulates rRNA expression",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5250924"
              }
            ],
            "id": "R-HSA-5250913",
            "label": "Positive epigenetic regulation of rRNA expression",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5250913"
          },
          {
            "groups": [
              {
                "id": "R-HSA-427413",
                "label": "NoRC negatively regulates rRNA expression",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-427413"
              },
              {
                "id": "R-HSA-427359",
                "label": "SIRT1 negatively regulates rRNA expression",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-427359"
              }
            ],
            "id": "R-HSA-5250941",
            "label": "Negative epigenetic regulation of rRNA expression",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5250941"
          },
          {
            "id": "R-HSA-212300",
            "label": "PRC2 methylates histones and DNA",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-212300"
          },
          {
            "id": "R-HSA-5334118",
            "label": "DNA methylation",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5334118"
          }
        ],
        "id": "R-HSA-212165",
        "label": "Epigenetic regulation of gene expression",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-212165"
      }
    ],
    "id": "R-HSA-74160",
    "label": "Gene expression (Transcription)",
    "weight": 130,
    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-74160"
  },
  {
    "groups": [
      {
        "groups": [
          {
            "groups": [
              {
                "id": "R-HSA-139853",
                "label": "Elevation of cytosolic Ca2+ levels",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-139853"
              },
              {
                "id": "R-HSA-418359",
                "label": "Reduction of cytosolic Ca++ levels",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-418359"
              }
            ],
            "id": "R-HSA-418360",
            "label": "Platelet calcium homeostasis",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-418360"
          },
          {
            "id": "R-HSA-432142",
            "label": "Platelet sensitization by LDL",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-432142"
          },
          {
            "groups": [
              {
                "id": "R-HSA-418457",
                "label": "cGMP effects",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-418457"
              }
            ],
            "id": "R-HSA-392154",
            "label": "Nitric oxide stimulates guanylate cyclase",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-392154"
          },
          {
            "id": "R-HSA-392851",
            "label": "Prostacyclin signalling through prostacyclin receptor",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-392851"
          }
        ],
        "id": "R-HSA-418346",
        "label": "Platelet homeostasis",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-418346"
      },
      {
        "groups": [
          {
            "id": "R-HSA-983189",
            "label": "Kinesins",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-983189"
          }
        ],
        "id": "R-HSA-983231",
        "label": "Factors involved in megakaryocyte development and platelet production",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-983231"
      },
      {
        "groups": [
          {
            "id": "R-HSA-210991",
            "label": "Basigin interactions",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-210991"
          },
          {
            "id": "R-HSA-210990",
            "label": "PECAM1 interactions",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-210990"
          },
          {
            "id": "R-HSA-210993",
            "label": "Tie2 Signaling",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-210993"
          }
        ],
        "id": "R-HSA-202733",
        "label": "Cell surface interactions at the vascular wall",
        "weight": 20,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-202733"
      },
      {
        "id": "R-HSA-75205",
        "label": "Dissolution of Fibrin Clot",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-75205"
      },
      {
        "groups": [
          {
            "id": "R-HSA-140834",
            "label": "Extrinsic Pathway of Fibrin Clot Formation",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-140834"
          },
          {
            "id": "R-HSA-140837",
            "label": "Intrinsic Pathway of Fibrin Clot Formation",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-140837"
          },
          {
            "id": "R-HSA-140875",
            "label": "Common Pathway of Fibrin Clot Formation",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-140875"
          }
        ],
        "id": "R-HSA-140877",
        "label": "Formation of Fibrin Clot (Clotting Cascade)",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-140877"
      },
      {
        "id": "R-HSA-75892",
        "label": "Platelet Adhesion to exposed collagen",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-75892"
      },
      {
        "groups": [
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-372708",
                    "label": "p130Cas linkage to MAPK signaling for integrins",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-372708"
                  },
                  {
                    "id": "R-HSA-354194",
                    "label": "GRB2:SOS provides linkage to MAPK signaling for Integrins ",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-354194"
                  }
                ],
                "id": "R-HSA-354192",
                "label": "Integrin alphaIIb beta3 signaling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-354192"
              },
              {
                "id": "R-HSA-392023",
                "label": "Adrenaline signalling through Alpha-2 adrenergic receptor",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-392023"
              }
            ],
            "id": "R-HSA-76009",
            "label": "Platelet Aggregation (Plug Formation)",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-76009"
          },
          {
            "groups": [
              {
                "id": "R-HSA-114516",
                "label": "Disinhibition of SNARE formation",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-114516"
              },
              {
                "id": "R-HSA-114608",
                "label": "Platelet degranulation ",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-114608"
              }
            ],
            "id": "R-HSA-76005",
            "label": "Response to elevated platelet cytosolic Ca2+",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-76005"
          },
          {
            "id": "R-HSA-430116",
            "label": "GP1b-IX-V activation signalling",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-430116"
          },
          {
            "groups": [
              {
                "id": "R-HSA-426048",
                "label": "Arachidonate production from DAG",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-426048"
              }
            ],
            "id": "R-HSA-114508",
            "label": "Effects of PIP2 hydrolysis",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-114508"
          },
          {
            "id": "R-HSA-114604",
            "label": "GPVI-mediated activation cascade",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-114604"
          },
          {
            "id": "R-HSA-456926",
            "label": "Thrombin signalling through proteinase activated receptors (PARs)",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-456926"
          },
          {
            "groups": [
              {
                "id": "R-HSA-418592",
                "label": "ADP signalling through P2Y purinoceptor 1",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-418592"
              },
              {
                "id": "R-HSA-428930",
                "label": "Thromboxane signalling through TP receptor",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-428930"
              },
              {
                "id": "R-HSA-392170",
                "label": "ADP signalling through P2Y purinoceptor 12",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-392170"
              }
            ],
            "id": "R-HSA-392518",
            "label": "Signal amplification",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-392518"
          }
        ],
        "id": "R-HSA-76002",
        "label": "Platelet activation, signaling and aggregation",
        "weight": 20,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-76002"
      }
    ],
    "id": "R-HSA-109582",
    "label": "Hemostasis",
    "weight": 60,
    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-109582"
  },
  {
    "groups": [
      {
        "groups": [
          {
            "groups": [
              {
                "id": "R-HSA-5669034",
                "label": "TNFs bind their physiological receptors",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5669034"
              },
              {
                "id": "R-HSA-5676594",
                "label": "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5676594"
              },
              {
                "id": "R-HSA-5676590",
                "label": "NIK-->noncanonical NF-kB signaling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5676590"
              }
            ],
            "id": "R-HSA-5668541",
            "label": "TNFR2 non-canonical NF-kB pathway",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5668541"
          },
          {
            "id": "R-HSA-1170546",
            "label": "Prolactin receptor signaling",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1170546"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-448706",
                    "label": "Interleukin-1 processing",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-448706"
                  },
                  {
                    "id": "R-HSA-9007892",
                    "label": "Interleukin-38 signaling",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9007892"
                  },
                  {
                    "id": "R-HSA-9008059",
                    "label": "Interleukin-37 signaling",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9008059"
                  },
                  {
                    "id": "R-HSA-9012546",
                    "label": "Interleukin-18 signaling",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9012546"
                  },
                  {
                    "id": "R-HSA-9014843",
                    "label": "Interleukin-33 signaling",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9014843"
                  },
                  {
                    "id": "R-HSA-9014826",
                    "label": "Interleukin-36 pathway",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9014826"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-5684264",
                        "label": "MAP3K8 (TPL2)-dependent MAPK1/3 activation",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5684264"
                      },
                      {
                        "id": "R-HSA-445989",
                        "label": "TAK1 activates NFkB by phosphorylation and activation of IKKs complex",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-445989"
                      }
                    ],
                    "id": "R-HSA-9020702",
                    "label": "Interleukin-1 signaling",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9020702"
                  }
                ],
                "id": "R-HSA-446652",
                "label": "Interleukin-1 family signaling",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-446652"
              },
              {
                "groups": [
                  {
                    "groups": [
                      {
                        "id": "R-HSA-8950505",
                        "label": "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation",
                        "weight": 10,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8950505"
                      }
                    ],
                    "id": "R-HSA-9020591",
                    "label": "Interleukin-12 signaling",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9020591"
                  },
                  {
                    "id": "R-HSA-9020933",
                    "label": "Interleukin-23 signaling",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9020933"
                  },
                  {
                    "id": "R-HSA-9020956",
                    "label": "Interleukin-27 signaling",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9020956"
                  },
                  {
                    "id": "R-HSA-8984722",
                    "label": "Interleukin-35 Signalling",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8984722"
                  }
                ],
                "id": "R-HSA-447115",
                "label": "Interleukin-12 family signaling",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-447115"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-912526",
                    "label": "Interleukin receptor SHC signaling",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-912526"
                  },
                  {
                    "id": "R-HSA-912631",
                    "label": "Regulation of signaling by CBL",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-912631"
                  }
                ],
                "id": "R-HSA-512988",
                "label": "Interleukin-3, Interleukin-5 and GM-CSF signaling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-512988"
              },
              {
                "groups": [
                  {
                    "groups": [
                      {
                        "id": "R-HSA-5684264",
                        "label": "MAP3K8 (TPL2)-dependent MAPK1/3 activation",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5684264"
                      },
                      {
                        "id": "R-HSA-450321",
                        "label": "JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450321"
                      },
                      {
                        "id": "R-HSA-450302",
                        "label": "activated TAK1 mediates p38 MAPK activation",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450302"
                      },
                      {
                        "groups": [
                          {
                            "groups": [
                              {
                                "id": "R-HSA-202670",
                                "label": "ERKs are inactivated",
                                "weight": 9,
                                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-202670"
                              }
                            ],
                            "id": "R-HSA-198753",
                            "label": "ERK/MAPK targets",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-198753"
                          },
                          {
                            "id": "R-HSA-199920",
                            "label": "CREB phosphorylation",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-199920"
                          },
                          {
                            "id": "R-HSA-450341",
                            "label": "Activation of the AP-1 family of transcription factors",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450341"
                          }
                        ],
                        "id": "R-HSA-450282",
                        "label": "MAPK targets/ Nuclear events mediated by MAP kinases",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450282"
                      }
                    ],
                    "id": "R-HSA-450294",
                    "label": "MAP kinase activation",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450294"
                  }
                ],
                "id": "R-HSA-448424",
                "label": "Interleukin-17 signaling",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-448424"
              },
              {
                "id": "R-HSA-449836",
                "label": "Other interleukin signaling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-449836"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-9020958",
                    "label": "Interleukin-21 signaling",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9020958"
                  },
                  {
                    "id": "R-HSA-9020558",
                    "label": "Interleukin-2 signaling",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9020558"
                  },
                  {
                    "id": "R-HSA-912526",
                    "label": "Interleukin receptor SHC signaling",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-912526"
                  },
                  {
                    "id": "R-HSA-8983432",
                    "label": "Interleukin-15 signaling",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8983432"
                  },
                  {
                    "id": "R-HSA-8985947",
                    "label": "Interleukin-9 signaling",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8985947"
                  }
                ],
                "id": "R-HSA-451927",
                "label": "Interleukin-2 family signaling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-451927"
              },
              {
                "id": "R-HSA-8854691",
                "label": "Interleukin-20 family signaling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8854691"
              },
              {
                "id": "R-HSA-1266695",
                "label": "Interleukin-7 signaling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1266695"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-6788467",
                    "label": "IL-6-type cytokine receptor ligand interactions",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6788467"
                  },
                  {
                    "id": "R-HSA-1059683",
                    "label": "Interleukin-6 signaling",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1059683"
                  }
                ],
                "id": "R-HSA-6783589",
                "label": "Interleukin-6 family signaling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6783589"
              },
              {
                "id": "R-HSA-6783783",
                "label": "Interleukin-10 signaling",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6783783"
              },
              {
                "id": "R-HSA-6785807",
                "label": "Interleukin-4 and Interleukin-13 signaling",
                "weight": 20,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6785807"
              }
            ],
            "id": "R-HSA-449147",
            "label": "Signaling by Interleukins",
            "weight": 50,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-449147"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-912694",
                    "label": "Regulation of IFNA signaling",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-912694"
                  }
                ],
                "id": "R-HSA-909733",
                "label": "Interferon alpha/beta signaling",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-909733"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-877312",
                    "label": "Regulation of IFNG signaling",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-877312"
                  }
                ],
                "id": "R-HSA-877300",
                "label": "Interferon gamma signaling",
                "weight": 20,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-877300"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-1169408",
                    "label": "ISG15 antiviral mechanism",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1169408"
                  },
                  {
                    "id": "R-HSA-8983711",
                    "label": "OAS antiviral response",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8983711"
                  }
                ],
                "id": "R-HSA-1169410",
                "label": "Antiviral mechanism by IFN-stimulated genes",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1169410"
              }
            ],
            "id": "R-HSA-913531",
            "label": "Interferon Signaling",
            "weight": 30,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-913531"
          },
          {
            "id": "R-HSA-982772",
            "label": "Growth hormone receptor signaling",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-982772"
          }
        ],
        "id": "R-HSA-1280215",
        "label": "Cytokine Signaling in Immune system",
        "weight": 80,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1280215"
      },
      {
        "groups": [
          {
            "id": "R-HSA-2132295",
            "label": "MHC class II antigen presentation",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2132295"
          },
          {
            "groups": [
              {
                "id": "R-HSA-389513",
                "label": "CTLA4 inhibitory signaling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-389513"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-389359",
                    "label": "CD28 dependent Vav1 pathway",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-389359"
                  },
                  {
                    "id": "R-HSA-389357",
                    "label": "CD28 dependent PI3K/Akt signaling",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-389357"
                  }
                ],
                "id": "R-HSA-389356",
                "label": "CD28 co-stimulation",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-389356"
              },
              {
                "id": "R-HSA-389948",
                "label": "PD-1 signaling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-389948"
              }
            ],
            "id": "R-HSA-388841",
            "label": "Costimulation by the CD28 family",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-388841"
          },
          {
            "id": "R-HSA-392517",
            "label": "Rap1 signalling",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-392517"
          },
          {
            "groups": [
              {
                "id": "R-HSA-983170",
                "label": "Antigen Presentation: Folding, assembly and peptide loading of class I MHC",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-983170"
              },
              {
                "id": "R-HSA-983168",
                "label": "Antigen processing: Ubiquitination & Proteasome degradation",
                "weight": 20,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-983168"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-1236974",
                    "label": "ER-Phagosome pathway",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1236974"
                  },
                  {
                    "id": "R-HSA-1236973",
                    "label": "Cross-presentation of particulate exogenous antigens (phagosomes)",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1236973"
                  },
                  {
                    "id": "R-HSA-1236978",
                    "label": "Cross-presentation of soluble exogenous antigens (endosomes)",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1236978"
                  },
                  {
                    "id": "R-HSA-1236977",
                    "label": "Endosomal/Vacuolar pathway",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1236977"
                  }
                ],
                "id": "R-HSA-1236975",
                "label": "Antigen processing-Cross presentation",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1236975"
              }
            ],
            "id": "R-HSA-983169",
            "label": "Class I MHC mediated antigen processing & presentation",
            "weight": 30,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-983169"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-1169092",
                    "label": "Activation of RAS in B cells",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1169092"
                  },
                  {
                    "id": "R-HSA-1169091",
                    "label": "Activation of NF-kappaB in B cells",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1169091"
                  },
                  {
                    "id": "R-HSA-2025928",
                    "label": "Calcineurin activates NFAT",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2025928"
                  }
                ],
                "id": "R-HSA-1168372",
                "label": "Downstream signaling events of B Cell Receptor (BCR)",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1168372"
              },
              {
                "id": "R-HSA-5690714",
                "label": "CD22 mediated BCR regulation",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5690714"
              },
              {
                "id": "R-HSA-983695",
                "label": "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-983695"
              }
            ],
            "id": "R-HSA-983705",
            "label": "Signaling by the B Cell Receptor (BCR)",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-983705"
          },
          {
            "id": "R-HSA-198933",
            "label": "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell",
            "weight": 20,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-198933"
          },
          {
            "id": "R-HSA-8851680",
            "label": "Butyrophilin (BTN) family interactions",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8851680"
          },
          {
            "groups": [
              {
                "id": "R-HSA-202424",
                "label": "Downstream TCR signaling",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-202424"
              },
              {
                "id": "R-HSA-202430",
                "label": "Translocation of ZAP-70 to Immunological synapse",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-202430"
              },
              {
                "id": "R-HSA-202427",
                "label": "Phosphorylation of CD3 and TCR zeta chains",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-202427"
              },
              {
                "id": "R-HSA-202433",
                "label": "Generation of second messenger molecules",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-202433"
              }
            ],
            "id": "R-HSA-202403",
            "label": "TCR signaling",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-202403"
          }
        ],
        "id": "R-HSA-1280218",
        "label": "Adaptive Immune System",
        "weight": 70,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1280218"
      },
      {
        "groups": [
          {
            "id": "R-HSA-879415",
            "label": "Advanced glycosylation endproduct receptor signaling",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-879415"
          },
          {
            "groups": [
              {
                "id": "R-HSA-2730905",
                "label": "Role of LAT2/NTAL/LAB on calcium mobilization",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2730905"
              },
              {
                "id": "R-HSA-2871837",
                "label": "FCERI mediated NF-kB activation",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2871837"
              },
              {
                "id": "R-HSA-2871809",
                "label": "FCERI mediated Ca+2 mobilization",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2871809"
              },
              {
                "id": "R-HSA-2871796",
                "label": "FCERI mediated MAPK activation",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2871796"
              }
            ],
            "id": "R-HSA-2454202",
            "label": "Fc epsilon receptor (FCERI) signaling",
            "weight": 20,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2454202"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "groups": [
                      {
                        "groups": [
                          {
                            "id": "R-HSA-2855086",
                            "label": "Ficolins bind to repetitive carbohydrate structures on the target cell surface",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2855086"
                          }
                        ],
                        "id": "R-HSA-166662",
                        "label": "Lectin pathway of complement activation",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-166662"
                      },
                      {
                        "id": "R-HSA-173623",
                        "label": "Classical antibody-mediated complement activation",
                        "weight": 10,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-173623"
                      }
                    ],
                    "id": "R-HSA-166786",
                    "label": "Creation of C4 and C2 activators",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-166786"
                  },
                  {
                    "id": "R-HSA-173736",
                    "label": "Alternative complement activation",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-173736"
                  }
                ],
                "id": "R-HSA-166663",
                "label": "Initial triggering of complement",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-166663"
              },
              {
                "id": "R-HSA-166665",
                "label": "Terminal pathway of complement",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-166665"
              },
              {
                "id": "R-HSA-174577",
                "label": "Activation of C3 and C5",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-174577"
              },
              {
                "id": "R-HSA-977606",
                "label": "Regulation of Complement cascade",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-977606"
              }
            ],
            "id": "R-HSA-166658",
            "label": "Complement cascade",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-166658"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-844623",
                    "label": "The IPAF inflammasome",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-844623"
                  },
                  {
                    "id": "R-HSA-844615",
                    "label": "The AIM2 inflammasome",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-844615"
                  },
                  {
                    "id": "R-HSA-844455",
                    "label": "The NLRP1 inflammasome",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-844455"
                  },
                  {
                    "id": "R-HSA-844456",
                    "label": "The NLRP3 inflammasome",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-844456"
                  }
                ],
                "id": "R-HSA-622312",
                "label": "Inflammasomes",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-622312"
              },
              {
                "id": "R-HSA-168638",
                "label": "NOD1/2 Signaling Pathway",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-168638"
              }
            ],
            "id": "R-HSA-168643",
            "label": "Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-168643"
          },
          {
            "groups": [
              {
                "id": "R-HSA-933542",
                "label": "TRAF6 mediated NF-kB activation",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-933542"
              },
              {
                "id": "R-HSA-933543",
                "label": "NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-933543"
              },
              {
                "id": "R-HSA-933541",
                "label": "TRAF6 mediated IRF7 activation",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-933541"
              },
              {
                "id": "R-HSA-936440",
                "label": "Negative regulators of DDX58/IFIH1 signaling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-936440"
              },
              {
                "id": "R-HSA-918233",
                "label": "TRAF3-dependent IRF activation pathway",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-918233"
              }
            ],
            "id": "R-HSA-168928",
            "label": "DDX58/IFIH1-mediated induction of interferon-alpha/beta",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-168928"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-166020",
                    "label": "Transfer of LPS from LBP carrier to CD14",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-166020"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-445989",
                        "label": "TAK1 activates NFkB by phosphorylation and activation of IKKs complex",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-445989"
                      },
                      {
                        "groups": [
                          {
                            "id": "R-HSA-5684264",
                            "label": "MAP3K8 (TPL2)-dependent MAPK1/3 activation",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5684264"
                          },
                          {
                            "id": "R-HSA-450321",
                            "label": "JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450321"
                          },
                          {
                            "id": "R-HSA-450302",
                            "label": "activated TAK1 mediates p38 MAPK activation",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450302"
                          },
                          {
                            "groups": [
                              {
                                "groups": [
                                  {
                                    "id": "R-HSA-202670",
                                    "label": "ERKs are inactivated",
                                    "weight": 9,
                                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-202670"
                                  }
                                ],
                                "id": "R-HSA-198753",
                                "label": "ERK/MAPK targets",
                                "weight": 9,
                                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-198753"
                              },
                              {
                                "id": "R-HSA-199920",
                                "label": "CREB phosphorylation",
                                "weight": 9,
                                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-199920"
                              },
                              {
                                "id": "R-HSA-450341",
                                "label": "Activation of the AP-1 family of transcription factors",
                                "weight": 9,
                                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450341"
                              }
                            ],
                            "id": "R-HSA-450282",
                            "label": "MAPK targets/ Nuclear events mediated by MAP kinases",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450282"
                          }
                        ],
                        "id": "R-HSA-450294",
                        "label": "MAP kinase activation",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450294"
                      },
                      {
                        "id": "R-HSA-937042",
                        "label": "IRAK2 mediated activation of TAK1 complex",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-937042"
                      },
                      {
                        "id": "R-HSA-937039",
                        "label": "IRAK1 recruits IKK complex",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-937039"
                      }
                    ],
                    "id": "R-HSA-166058",
                    "label": "MyD88:MAL(TIRAP) cascade initiated on plasma membrane",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-166058"
                  },
                  {
                    "groups": [
                      {
                        "groups": [
                          {
                            "id": "R-HSA-445989",
                            "label": "TAK1 activates NFkB by phosphorylation and activation of IKKs complex",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-445989"
                          },
                          {
                            "groups": [
                              {
                                "id": "R-HSA-5684264",
                                "label": "MAP3K8 (TPL2)-dependent MAPK1/3 activation",
                                "weight": 9,
                                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5684264"
                              },
                              {
                                "id": "R-HSA-450321",
                                "label": "JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1",
                                "weight": 9,
                                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450321"
                              },
                              {
                                "id": "R-HSA-450302",
                                "label": "activated TAK1 mediates p38 MAPK activation",
                                "weight": 9,
                                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450302"
                              },
                              {
                                "groups": [
                                  {
                                    "groups": [
                                      {
                                        "id": "R-HSA-202670",
                                        "label": "ERKs are inactivated",
                                        "weight": 9,
                                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-202670"
                                      }
                                    ],
                                    "id": "R-HSA-198753",
                                    "label": "ERK/MAPK targets",
                                    "weight": 9,
                                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-198753"
                                  },
                                  {
                                    "id": "R-HSA-199920",
                                    "label": "CREB phosphorylation",
                                    "weight": 9,
                                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-199920"
                                  },
                                  {
                                    "id": "R-HSA-450341",
                                    "label": "Activation of the AP-1 family of transcription factors",
                                    "weight": 9,
                                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450341"
                                  }
                                ],
                                "id": "R-HSA-450282",
                                "label": "MAPK targets/ Nuclear events mediated by MAP kinases",
                                "weight": 9,
                                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450282"
                              }
                            ],
                            "id": "R-HSA-450294",
                            "label": "MAP kinase activation",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450294"
                          },
                          {
                            "id": "R-HSA-2562578",
                            "label": "TRIF-mediated programmed cell death",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2562578"
                          },
                          {
                            "id": "R-HSA-937041",
                            "label": "IKK complex recruitment mediated by RIP1",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-937041"
                          },
                          {
                            "id": "R-HSA-937072",
                            "label": "TRAF6-mediated induction of TAK1 complex within TLR4 complex",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-937072"
                          },
                          {
                            "id": "R-HSA-936964",
                            "label": "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-936964"
                          }
                        ],
                        "id": "R-HSA-937061",
                        "label": "TRIF(TICAM1)-mediated TLR4 signaling ",
                        "weight": 10,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-937061"
                      }
                    ],
                    "id": "R-HSA-166166",
                    "label": "MyD88-independent TLR4 cascade ",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-166166"
                  }
                ],
                "id": "R-HSA-166016",
                "label": "Toll Like Receptor 4 (TLR4) Cascade",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-166016"
              },
              {
                "groups": [
                  {
                    "groups": [
                      {
                        "groups": [
                          {
                            "id": "R-HSA-445989",
                            "label": "TAK1 activates NFkB by phosphorylation and activation of IKKs complex",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-445989"
                          },
                          {
                            "groups": [
                              {
                                "id": "R-HSA-5684264",
                                "label": "MAP3K8 (TPL2)-dependent MAPK1/3 activation",
                                "weight": 9,
                                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5684264"
                              },
                              {
                                "id": "R-HSA-450321",
                                "label": "JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1",
                                "weight": 9,
                                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450321"
                              },
                              {
                                "id": "R-HSA-450302",
                                "label": "activated TAK1 mediates p38 MAPK activation",
                                "weight": 9,
                                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450302"
                              },
                              {
                                "groups": [
                                  {
                                    "groups": [
                                      {
                                        "id": "R-HSA-202670",
                                        "label": "ERKs are inactivated",
                                        "weight": 9,
                                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-202670"
                                      }
                                    ],
                                    "id": "R-HSA-198753",
                                    "label": "ERK/MAPK targets",
                                    "weight": 9,
                                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-198753"
                                  },
                                  {
                                    "id": "R-HSA-199920",
                                    "label": "CREB phosphorylation",
                                    "weight": 9,
                                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-199920"
                                  },
                                  {
                                    "id": "R-HSA-450341",
                                    "label": "Activation of the AP-1 family of transcription factors",
                                    "weight": 9,
                                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450341"
                                  }
                                ],
                                "id": "R-HSA-450282",
                                "label": "MAPK targets/ Nuclear events mediated by MAP kinases",
                                "weight": 9,
                                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450282"
                              }
                            ],
                            "id": "R-HSA-450294",
                            "label": "MAP kinase activation",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450294"
                          },
                          {
                            "id": "R-HSA-975163",
                            "label": "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-975163"
                          },
                          {
                            "id": "R-HSA-975144",
                            "label": "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-975144"
                          }
                        ],
                        "id": "R-HSA-975138",
                        "label": "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation",
                        "weight": 10,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-975138"
                      },
                      {
                        "id": "R-HSA-975110",
                        "label": "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-975110"
                      }
                    ],
                    "id": "R-HSA-975155",
                    "label": "MyD88 dependent cascade initiated on endosome",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-975155"
                  }
                ],
                "id": "R-HSA-168138",
                "label": "Toll Like Receptor 9 (TLR9) Cascade",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-168138"
              },
              {
                "groups": [
                  {
                    "groups": [
                      {
                        "id": "R-HSA-445989",
                        "label": "TAK1 activates NFkB by phosphorylation and activation of IKKs complex",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-445989"
                      },
                      {
                        "groups": [
                          {
                            "id": "R-HSA-5684264",
                            "label": "MAP3K8 (TPL2)-dependent MAPK1/3 activation",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5684264"
                          },
                          {
                            "id": "R-HSA-450321",
                            "label": "JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450321"
                          },
                          {
                            "id": "R-HSA-450302",
                            "label": "activated TAK1 mediates p38 MAPK activation",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450302"
                          },
                          {
                            "groups": [
                              {
                                "groups": [
                                  {
                                    "id": "R-HSA-202670",
                                    "label": "ERKs are inactivated",
                                    "weight": 9,
                                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-202670"
                                  }
                                ],
                                "id": "R-HSA-198753",
                                "label": "ERK/MAPK targets",
                                "weight": 9,
                                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-198753"
                              },
                              {
                                "id": "R-HSA-199920",
                                "label": "CREB phosphorylation",
                                "weight": 9,
                                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-199920"
                              },
                              {
                                "id": "R-HSA-450341",
                                "label": "Activation of the AP-1 family of transcription factors",
                                "weight": 9,
                                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450341"
                              }
                            ],
                            "id": "R-HSA-450282",
                            "label": "MAPK targets/ Nuclear events mediated by MAP kinases",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450282"
                          }
                        ],
                        "id": "R-HSA-450294",
                        "label": "MAP kinase activation",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450294"
                      },
                      {
                        "id": "R-HSA-937042",
                        "label": "IRAK2 mediated activation of TAK1 complex",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-937042"
                      },
                      {
                        "id": "R-HSA-937039",
                        "label": "IRAK1 recruits IKK complex",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-937039"
                      }
                    ],
                    "id": "R-HSA-975871",
                    "label": "MyD88 cascade initiated on plasma membrane",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-975871"
                  }
                ],
                "id": "R-HSA-168142",
                "label": "Toll Like Receptor 10 (TLR10) Cascade",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-168142"
              },
              {
                "groups": [
                  {
                    "groups": [
                      {
                        "groups": [
                          {
                            "id": "R-HSA-445989",
                            "label": "TAK1 activates NFkB by phosphorylation and activation of IKKs complex",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-445989"
                          },
                          {
                            "groups": [
                              {
                                "id": "R-HSA-5684264",
                                "label": "MAP3K8 (TPL2)-dependent MAPK1/3 activation",
                                "weight": 9,
                                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5684264"
                              },
                              {
                                "id": "R-HSA-450321",
                                "label": "JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1",
                                "weight": 9,
                                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450321"
                              },
                              {
                                "id": "R-HSA-450302",
                                "label": "activated TAK1 mediates p38 MAPK activation",
                                "weight": 9,
                                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450302"
                              },
                              {
                                "groups": [
                                  {
                                    "groups": [
                                      {
                                        "id": "R-HSA-202670",
                                        "label": "ERKs are inactivated",
                                        "weight": 9,
                                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-202670"
                                      }
                                    ],
                                    "id": "R-HSA-198753",
                                    "label": "ERK/MAPK targets",
                                    "weight": 9,
                                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-198753"
                                  },
                                  {
                                    "id": "R-HSA-199920",
                                    "label": "CREB phosphorylation",
                                    "weight": 9,
                                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-199920"
                                  },
                                  {
                                    "id": "R-HSA-450341",
                                    "label": "Activation of the AP-1 family of transcription factors",
                                    "weight": 9,
                                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450341"
                                  }
                                ],
                                "id": "R-HSA-450282",
                                "label": "MAPK targets/ Nuclear events mediated by MAP kinases",
                                "weight": 9,
                                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450282"
                              }
                            ],
                            "id": "R-HSA-450294",
                            "label": "MAP kinase activation",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450294"
                          },
                          {
                            "id": "R-HSA-975163",
                            "label": "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-975163"
                          },
                          {
                            "id": "R-HSA-975144",
                            "label": "IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-975144"
                          }
                        ],
                        "id": "R-HSA-975138",
                        "label": "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation",
                        "weight": 10,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-975138"
                      },
                      {
                        "id": "R-HSA-975110",
                        "label": "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-975110"
                      }
                    ],
                    "id": "R-HSA-975155",
                    "label": "MyD88 dependent cascade initiated on endosome",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-975155"
                  }
                ],
                "id": "R-HSA-168181",
                "label": "Toll Like Receptor 7/8 (TLR7/8) Cascade",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-168181"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-9013973",
                    "label": "TICAM1-dependent activation of IRF3/IRF7",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9013973"
                  },
                  {
                    "id": "R-HSA-9013957",
                    "label": "TLR3-mediated TICAM1-dependent programmed cell death",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9013957"
                  },
                  {
                    "id": "R-HSA-9014325",
                    "label": "TICAM1,TRAF6-dependent induction of TAK1 complex",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9014325"
                  },
                  {
                    "id": "R-HSA-168927",
                    "label": "TICAM1, RIP1-mediated IKK complex recruitment ",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-168927"
                  },
                  {
                    "id": "R-HSA-445989",
                    "label": "TAK1 activates NFkB by phosphorylation and activation of IKKs complex",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-445989"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-5684264",
                        "label": "MAP3K8 (TPL2)-dependent MAPK1/3 activation",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5684264"
                      },
                      {
                        "id": "R-HSA-450321",
                        "label": "JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450321"
                      },
                      {
                        "id": "R-HSA-450302",
                        "label": "activated TAK1 mediates p38 MAPK activation",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450302"
                      },
                      {
                        "groups": [
                          {
                            "groups": [
                              {
                                "id": "R-HSA-202670",
                                "label": "ERKs are inactivated",
                                "weight": 9,
                                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-202670"
                              }
                            ],
                            "id": "R-HSA-198753",
                            "label": "ERK/MAPK targets",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-198753"
                          },
                          {
                            "id": "R-HSA-199920",
                            "label": "CREB phosphorylation",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-199920"
                          },
                          {
                            "id": "R-HSA-450341",
                            "label": "Activation of the AP-1 family of transcription factors",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450341"
                          }
                        ],
                        "id": "R-HSA-450282",
                        "label": "MAPK targets/ Nuclear events mediated by MAP kinases",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450282"
                      }
                    ],
                    "id": "R-HSA-450294",
                    "label": "MAP kinase activation",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450294"
                  }
                ],
                "id": "R-HSA-168164",
                "label": "Toll Like Receptor 3 (TLR3) Cascade",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-168164"
              },
              {
                "groups": [
                  {
                    "groups": [
                      {
                        "id": "R-HSA-445989",
                        "label": "TAK1 activates NFkB by phosphorylation and activation of IKKs complex",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-445989"
                      },
                      {
                        "groups": [
                          {
                            "id": "R-HSA-5684264",
                            "label": "MAP3K8 (TPL2)-dependent MAPK1/3 activation",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5684264"
                          },
                          {
                            "id": "R-HSA-450321",
                            "label": "JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450321"
                          },
                          {
                            "id": "R-HSA-450302",
                            "label": "activated TAK1 mediates p38 MAPK activation",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450302"
                          },
                          {
                            "groups": [
                              {
                                "groups": [
                                  {
                                    "id": "R-HSA-202670",
                                    "label": "ERKs are inactivated",
                                    "weight": 9,
                                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-202670"
                                  }
                                ],
                                "id": "R-HSA-198753",
                                "label": "ERK/MAPK targets",
                                "weight": 9,
                                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-198753"
                              },
                              {
                                "id": "R-HSA-199920",
                                "label": "CREB phosphorylation",
                                "weight": 9,
                                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-199920"
                              },
                              {
                                "id": "R-HSA-450341",
                                "label": "Activation of the AP-1 family of transcription factors",
                                "weight": 9,
                                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450341"
                              }
                            ],
                            "id": "R-HSA-450282",
                            "label": "MAPK targets/ Nuclear events mediated by MAP kinases",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450282"
                          }
                        ],
                        "id": "R-HSA-450294",
                        "label": "MAP kinase activation",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450294"
                      },
                      {
                        "id": "R-HSA-937042",
                        "label": "IRAK2 mediated activation of TAK1 complex",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-937042"
                      },
                      {
                        "id": "R-HSA-937039",
                        "label": "IRAK1 recruits IKK complex",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-937039"
                      }
                    ],
                    "id": "R-HSA-975871",
                    "label": "MyD88 cascade initiated on plasma membrane",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-975871"
                  }
                ],
                "id": "R-HSA-168176",
                "label": "Toll Like Receptor 5 (TLR5) Cascade",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-168176"
              },
              {
                "id": "R-HSA-1679131",
                "label": "Trafficking and processing of endosomal TLR",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1679131"
              },
              {
                "groups": [
                  {
                    "groups": [
                      {
                        "groups": [
                          {
                            "id": "R-HSA-445989",
                            "label": "TAK1 activates NFkB by phosphorylation and activation of IKKs complex",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-445989"
                          },
                          {
                            "groups": [
                              {
                                "id": "R-HSA-5684264",
                                "label": "MAP3K8 (TPL2)-dependent MAPK1/3 activation",
                                "weight": 9,
                                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5684264"
                              },
                              {
                                "id": "R-HSA-450321",
                                "label": "JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1",
                                "weight": 9,
                                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450321"
                              },
                              {
                                "id": "R-HSA-450302",
                                "label": "activated TAK1 mediates p38 MAPK activation",
                                "weight": 9,
                                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450302"
                              },
                              {
                                "groups": [
                                  {
                                    "groups": [
                                      {
                                        "id": "R-HSA-202670",
                                        "label": "ERKs are inactivated",
                                        "weight": 9,
                                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-202670"
                                      }
                                    ],
                                    "id": "R-HSA-198753",
                                    "label": "ERK/MAPK targets",
                                    "weight": 9,
                                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-198753"
                                  },
                                  {
                                    "id": "R-HSA-199920",
                                    "label": "CREB phosphorylation",
                                    "weight": 9,
                                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-199920"
                                  },
                                  {
                                    "id": "R-HSA-450341",
                                    "label": "Activation of the AP-1 family of transcription factors",
                                    "weight": 9,
                                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450341"
                                  }
                                ],
                                "id": "R-HSA-450282",
                                "label": "MAPK targets/ Nuclear events mediated by MAP kinases",
                                "weight": 9,
                                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450282"
                              }
                            ],
                            "id": "R-HSA-450294",
                            "label": "MAP kinase activation",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450294"
                          },
                          {
                            "id": "R-HSA-937042",
                            "label": "IRAK2 mediated activation of TAK1 complex",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-937042"
                          },
                          {
                            "id": "R-HSA-937039",
                            "label": "IRAK1 recruits IKK complex",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-937039"
                          }
                        ],
                        "id": "R-HSA-166058",
                        "label": "MyD88:MAL(TIRAP) cascade initiated on plasma membrane",
                        "weight": 10,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-166058"
                      }
                    ],
                    "id": "R-HSA-168188",
                    "label": "Toll Like Receptor TLR6:TLR2 Cascade",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-168188"
                  },
                  {
                    "groups": [
                      {
                        "groups": [
                          {
                            "id": "R-HSA-445989",
                            "label": "TAK1 activates NFkB by phosphorylation and activation of IKKs complex",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-445989"
                          },
                          {
                            "groups": [
                              {
                                "id": "R-HSA-5684264",
                                "label": "MAP3K8 (TPL2)-dependent MAPK1/3 activation",
                                "weight": 9,
                                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5684264"
                              },
                              {
                                "id": "R-HSA-450321",
                                "label": "JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1",
                                "weight": 9,
                                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450321"
                              },
                              {
                                "id": "R-HSA-450302",
                                "label": "activated TAK1 mediates p38 MAPK activation",
                                "weight": 9,
                                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450302"
                              },
                              {
                                "groups": [
                                  {
                                    "groups": [
                                      {
                                        "id": "R-HSA-202670",
                                        "label": "ERKs are inactivated",
                                        "weight": 9,
                                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-202670"
                                      }
                                    ],
                                    "id": "R-HSA-198753",
                                    "label": "ERK/MAPK targets",
                                    "weight": 9,
                                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-198753"
                                  },
                                  {
                                    "id": "R-HSA-199920",
                                    "label": "CREB phosphorylation",
                                    "weight": 9,
                                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-199920"
                                  },
                                  {
                                    "id": "R-HSA-450341",
                                    "label": "Activation of the AP-1 family of transcription factors",
                                    "weight": 9,
                                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450341"
                                  }
                                ],
                                "id": "R-HSA-450282",
                                "label": "MAPK targets/ Nuclear events mediated by MAP kinases",
                                "weight": 9,
                                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450282"
                              }
                            ],
                            "id": "R-HSA-450294",
                            "label": "MAP kinase activation",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450294"
                          },
                          {
                            "id": "R-HSA-937042",
                            "label": "IRAK2 mediated activation of TAK1 complex",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-937042"
                          },
                          {
                            "id": "R-HSA-937039",
                            "label": "IRAK1 recruits IKK complex",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-937039"
                          }
                        ],
                        "id": "R-HSA-166058",
                        "label": "MyD88:MAL(TIRAP) cascade initiated on plasma membrane",
                        "weight": 10,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-166058"
                      }
                    ],
                    "id": "R-HSA-168179",
                    "label": "Toll Like Receptor TLR1:TLR2 Cascade",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-168179"
                  }
                ],
                "id": "R-HSA-181438",
                "label": "Toll Like Receptor 2 (TLR2) Cascade",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-181438"
              },
              {
                "id": "R-HSA-5686938",
                "label": "Regulation of TLR by endogenous ligand",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5686938"
              }
            ],
            "id": "R-HSA-168898",
            "label": "Toll-like Receptor Cascades",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-168898"
          },
          {
            "groups": [
              {
                "id": "R-HSA-8941413",
                "label": "Events associated with phagocytolytic activity of PMN cells",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8941413"
              }
            ],
            "id": "R-HSA-1222556",
            "label": "ROS, RNS production in phagocytes",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1222556"
          },
          {
            "id": "R-HSA-6798695",
            "label": "Neutrophil degranulation",
            "weight": 30,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6798695"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-5607763",
                    "label": "CLEC7A (Dectin-1) induces NFAT activation",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5607763"
                  },
                  {
                    "id": "R-HSA-5607761",
                    "label": "Dectin-1 mediated noncanonical NF-kB signaling",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5607761"
                  },
                  {
                    "id": "R-HSA-5660668",
                    "label": "CLEC7A/inflammasome pathway",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5660668"
                  }
                ],
                "id": "R-HSA-5607764",
                "label": "CLEC7A (Dectin-1) signaling",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5607764"
              },
              {
                "id": "R-HSA-5621480",
                "label": "Dectin-2 family",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5621480"
              },
              {
                "id": "R-HSA-5621575",
                "label": "CD209 (DC-SIGN) signaling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5621575"
              }
            ],
            "id": "R-HSA-5621481",
            "label": "C-type lectin receptors (CLRs)",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5621481"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-1462054",
                    "label": "Alpha-defensins",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1462054"
                  },
                  {
                    "id": "R-HSA-1461957",
                    "label": "Beta defensins",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1461957"
                  }
                ],
                "id": "R-HSA-1461973",
                "label": "Defensins",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1461973"
              },
              {
                "id": "R-HSA-6799990",
                "label": "Metal sequestration by antimicrobial proteins",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6799990"
              },
              {
                "id": "R-HSA-6803544",
                "label": "Ion influx/efflux at host-pathogen interface",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6803544"
              }
            ],
            "id": "R-HSA-6803157",
            "label": "Antimicrobial peptides",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6803157"
          },
          {
            "groups": [
              {
                "id": "R-HSA-2029485",
                "label": "Role of phospholipids in phagocytosis",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2029485"
              },
              {
                "id": "R-HSA-2029482",
                "label": "Regulation of actin dynamics for phagocytic cup formation",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2029482"
              },
              {
                "id": "R-HSA-2029481",
                "label": "FCGR activation",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2029481"
              }
            ],
            "id": "R-HSA-2029480",
            "label": "Fcgamma receptor (FCGR) dependent phagocytosis",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2029480"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-1606341",
                    "label": "IRF3 mediated activation of type 1 IFN",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1606341"
                  },
                  {
                    "id": "R-HSA-1810476",
                    "label": "RIP-mediated NFkB activation via ZBP1",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1810476"
                  }
                ],
                "id": "R-HSA-1606322",
                "label": "ZBP1(DAI) mediated induction of type I IFNs",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1606322"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-3248023",
                    "label": "Regulation by TREX1",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3248023"
                  }
                ],
                "id": "R-HSA-3134975",
                "label": "Regulation of innate immune responses to cytosolic DNA",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3134975"
              },
              {
                "id": "R-HSA-3134973",
                "label": "LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3134973"
              },
              {
                "id": "R-HSA-3134963",
                "label": "DEx/H-box helicases activate type I IFN and inflammatory cytokines production ",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3134963"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-3249367",
                    "label": "STAT6-mediated induction of chemokines",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3249367"
                  },
                  {
                    "id": "R-HSA-3270619",
                    "label": "IRF3-mediated induction of type I IFN",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3270619"
                  }
                ],
                "id": "R-HSA-1834941",
                "label": "STING mediated induction of host immune responses",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1834941"
              }
            ],
            "id": "R-HSA-1834949",
            "label": "Cytosolic sensors of pathogen-associated DNA ",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1834949"
          },
          {
            "groups": [
              {
                "id": "R-HSA-2424491",
                "label": "DAP12 signaling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2424491"
              }
            ],
            "id": "R-HSA-2172127",
            "label": "DAP12 interactions",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2172127"
          }
        ],
        "id": "R-HSA-168249",
        "label": "Innate Immune System",
        "weight": 90,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-168249"
      }
    ],
    "id": "R-HSA-168256",
    "label": "Immune System",
    "weight": 190,
    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-168256"
  },
  {
    "groups": [
      {
        "groups": [
          {
            "id": "R-HSA-499943",
            "label": "Interconversion of nucleotide di- and triphosphates",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-499943"
          },
          {
            "groups": [
              {
                "id": "R-HSA-8850843",
                "label": "Phosphate bond hydrolysis by NTPDase proteins",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8850843"
              },
              {
                "id": "R-HSA-73621",
                "label": "Pyrimidine catabolism",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-73621"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-2393930",
                    "label": "Phosphate bond hydrolysis by NUDT proteins",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2393930"
                  }
                ],
                "id": "R-HSA-74259",
                "label": "Purine catabolism",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-74259"
              }
            ],
            "id": "R-HSA-8956319",
            "label": "Nucleobase catabolism",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8956319"
          },
          {
            "groups": [
              {
                "id": "R-HSA-500753",
                "label": "Pyrimidine biosynthesis",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-500753"
              },
              {
                "id": "R-HSA-73817",
                "label": "Purine ribonucleoside monophosphate biosynthesis",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-73817"
              }
            ],
            "id": "R-HSA-8956320",
            "label": "Nucleobase biosynthesis",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8956320"
          },
          {
            "groups": [
              {
                "id": "R-HSA-73614",
                "label": "Pyrimidine salvage",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-73614"
              },
              {
                "id": "R-HSA-74217",
                "label": "Purine salvage",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-74217"
              }
            ],
            "id": "R-HSA-8956321",
            "label": "Nucleotide salvage",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8956321"
          }
        ],
        "id": "R-HSA-15869",
        "label": "Metabolism of nucleotides",
        "weight": 20,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-15869"
      },
      {
        "groups": [
          {
            "groups": [
              {
                "id": "R-HSA-381676",
                "label": "Glucagon-like Peptide-1 (GLP1) regulates insulin secretion",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-381676"
              },
              {
                "id": "R-HSA-400042",
                "label": "Adrenaline,noradrenaline inhibits insulin secretion",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-400042"
              },
              {
                "id": "R-HSA-399997",
                "label": "Acetylcholine regulates insulin secretion",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-399997"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-434316",
                    "label": "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-434316"
                  }
                ],
                "id": "R-HSA-400451",
                "label": "Free fatty acids regulate insulin secretion",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-400451"
              }
            ],
            "id": "R-HSA-422356",
            "label": "Regulation of insulin secretion",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-422356"
          },
          {
            "groups": [
              {
                "id": "R-HSA-164378",
                "label": "PKA activation in glucagon signalling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-164378"
              }
            ],
            "id": "R-HSA-163359",
            "label": "Glucagon signaling in metabolic regulation",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-163359"
          },
          {
            "id": "R-HSA-163358",
            "label": "PKA-mediated phosphorylation of key metabolic factors",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-163358"
          },
          {
            "id": "R-HSA-163754",
            "label": "Insulin effects increased synthesis of Xylulose-5-Phosphate",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-163754"
          },
          {
            "id": "R-HSA-163767",
            "label": "PP2A-mediated dephosphorylation of key metabolic factors",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-163767"
          },
          {
            "id": "R-HSA-163765",
            "label": "ChREBP activates metabolic gene expression",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-163765"
          },
          {
            "id": "R-HSA-163680",
            "label": "AMPK inhibits chREBP transcriptional activation activity",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-163680"
          }
        ],
        "id": "R-HSA-163685",
        "label": "Integration of energy metabolism",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-163685"
      },
      {
        "groups": [
          {
            "groups": [
              {
                "id": "R-HSA-2142700",
                "label": "Synthesis of Lipoxins (LX)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2142700"
              },
              {
                "groups": [
                  {
                    "groups": [
                      {
                        "id": "R-HSA-9027307",
                        "label": "Biosynthesis of maresin-like SPMs",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9027307"
                      }
                    ],
                    "id": "R-HSA-9018682",
                    "label": "Biosynthesis of maresins",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9018682"
                  },
                  {
                    "id": "R-HSA-9018681",
                    "label": "Biosynthesis of protectins",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9018681"
                  },
                  {
                    "id": "R-HSA-9018676",
                    "label": "Biosynthesis of D-series resolvins",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9018676"
                  },
                  {
                    "id": "R-HSA-9020265",
                    "label": "Biosynthesis of aspirin-triggered D-series resolvins",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9020265"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-9026766",
                        "label": "Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9026766"
                      },
                      {
                        "id": "R-HSA-9026762",
                        "label": "Biosynthesis of maresin conjugates in tissue regeneration (MCTR)",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9026762"
                      }
                    ],
                    "id": "R-HSA-9026395",
                    "label": "Biosynthesis of DHA-derived sulfido conjugates",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9026395"
                  }
                ],
                "id": "R-HSA-9018677",
                "label": "Biosynthesis of DHA-derived SPMs",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9018677"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-9023661",
                    "label": "Biosynthesis of E-series 18(R)-resolvins",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9023661"
                  },
                  {
                    "id": "R-HSA-9018896",
                    "label": "Biosynthesis of E-series 18(S)-resolvins",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9018896"
                  }
                ],
                "id": "R-HSA-9018679",
                "label": "Biosynthesis of EPA-derived SPMs",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9018679"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-9025106",
                    "label": "Biosynthesis of DPAn-6 SPMs",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9025106"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-9026290",
                        "label": "Biosynthesis of DPAn-3-derived maresins",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9026290"
                      },
                      {
                        "id": "R-HSA-9026286",
                        "label": "Biosynthesis of DPAn-3-derived protectins and resolvins",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9026286"
                      },
                      {
                        "id": "R-HSA-9026403",
                        "label": "Biosynthesis of DPAn-3-derived 13-series resolvins",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9026403"
                      }
                    ],
                    "id": "R-HSA-9025094",
                    "label": "Biosynthesis of DPAn-3 SPMs",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9025094"
                  }
                ],
                "id": "R-HSA-9018683",
                "label": "Biosynthesis of DPA-derived SPMs",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9018683"
              },
              {
                "id": "R-HSA-9027604",
                "label": "Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9027604"
              }
            ],
            "id": "R-HSA-9018678",
            "label": "Biosynthesis of specialized proresolving mediators (SPMs)",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9018678"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-1482922",
                    "label": "Acyl chain remodelling of PI",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1482922"
                  },
                  {
                    "id": "R-HSA-1482925",
                    "label": "Acyl chain remodelling of PG",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1482925"
                  },
                  {
                    "id": "R-HSA-1482839",
                    "label": "Acyl chain remodelling of PE",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1482839"
                  },
                  {
                    "id": "R-HSA-1482883",
                    "label": "Acyl chain remodeling of DAG and TAG",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1482883"
                  },
                  {
                    "id": "R-HSA-1482788",
                    "label": "Acyl chain remodelling of PC",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1482788"
                  },
                  {
                    "id": "R-HSA-1482798",
                    "label": "Acyl chain remodeling of CL",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1482798"
                  },
                  {
                    "id": "R-HSA-1482801",
                    "label": "Acyl chain remodelling of PS",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1482801"
                  },
                  {
                    "id": "R-HSA-1483226",
                    "label": "Synthesis of PI",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1483226"
                  },
                  {
                    "id": "R-HSA-1483213",
                    "label": "Synthesis of PE",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1483213"
                  },
                  {
                    "id": "R-HSA-1483171",
                    "label": "Synthesis of BMP",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1483171"
                  },
                  {
                    "id": "R-HSA-1483166",
                    "label": "Synthesis of PA",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1483166"
                  },
                  {
                    "id": "R-HSA-1483148",
                    "label": "Synthesis of PG",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1483148"
                  },
                  {
                    "id": "R-HSA-1483152",
                    "label": "Hydrolysis of LPE",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1483152"
                  },
                  {
                    "id": "R-HSA-1483196",
                    "label": "PI and PC transport between ER and Golgi membranes",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1483196"
                  },
                  {
                    "id": "R-HSA-1483191",
                    "label": "Synthesis of PC",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1483191"
                  },
                  {
                    "id": "R-HSA-1483101",
                    "label": "Synthesis of PS",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1483101"
                  },
                  {
                    "id": "R-HSA-1483115",
                    "label": "Hydrolysis of LPC",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1483115"
                  },
                  {
                    "id": "R-HSA-1483076",
                    "label": "Synthesis of CL",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1483076"
                  }
                ],
                "id": "R-HSA-1483206",
                "label": "Glycerophospholipid biosynthesis",
                "weight": 20,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1483206"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-1483248",
                    "label": "Synthesis of PIPs at the ER membrane",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1483248"
                  },
                  {
                    "id": "R-HSA-1483196",
                    "label": "PI and PC transport between ER and Golgi membranes",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1483196"
                  },
                  {
                    "id": "R-HSA-6814848",
                    "label": "Glycerophospholipid catabolism",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6814848"
                  },
                  {
                    "id": "R-HSA-8847453",
                    "label": "Synthesis of PIPs in the nucleus",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8847453"
                  },
                  {
                    "id": "R-HSA-1660524",
                    "label": "PIPs transport between plasma and early endosome membranes",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1660524"
                  },
                  {
                    "id": "R-HSA-1660510",
                    "label": "PIPs transport between Golgi and plasma membranes",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1660510"
                  },
                  {
                    "id": "R-HSA-1660508",
                    "label": "PIPs transport between late endosome and Golgi membranes",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1660508"
                  },
                  {
                    "id": "R-HSA-1660517",
                    "label": "Synthesis of PIPs at the late endosome membrane",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1660517"
                  },
                  {
                    "id": "R-HSA-1660516",
                    "label": "Synthesis of PIPs at the early endosome membrane",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1660516"
                  },
                  {
                    "id": "R-HSA-1660514",
                    "label": "Synthesis of PIPs at the Golgi membrane",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1660514"
                  },
                  {
                    "id": "R-HSA-1660537",
                    "label": "PIPs transport between early endosome and Golgi membranes",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1660537"
                  },
                  {
                    "id": "R-HSA-1660502",
                    "label": "PIPs transport between early and late endosome membranes",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1660502"
                  },
                  {
                    "id": "R-HSA-1660499",
                    "label": "Synthesis of PIPs at the plasma membrane",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1660499"
                  }
                ],
                "id": "R-HSA-1483255",
                "label": "PI Metabolism",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1483255"
              }
            ],
            "id": "R-HSA-1483257",
            "label": "Phospholipid metabolism",
            "weight": 20,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1483257"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-193144",
                    "label": "Estrogen biosynthesis",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-193144"
                  },
                  {
                    "id": "R-HSA-193048",
                    "label": "Androgen biosynthesis",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-193048"
                  },
                  {
                    "id": "R-HSA-194002",
                    "label": "Glucocorticoid biosynthesis",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-194002"
                  },
                  {
                    "id": "R-HSA-193993",
                    "label": "Mineralocorticoid biosynthesis",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-193993"
                  },
                  {
                    "id": "R-HSA-196108",
                    "label": "Pregnenolone biosynthesis",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-196108"
                  }
                ],
                "id": "R-HSA-196071",
                "label": "Metabolism of steroid hormones",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-196071"
              },
              {
                "id": "R-HSA-196791",
                "label": "Vitamin D (calciferol) metabolism",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-196791"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-2426168",
                    "label": "Activation of gene expression by SREBF (SREBP)",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2426168"
                  }
                ],
                "id": "R-HSA-1655829",
                "label": "Regulation of cholesterol biosynthesis by SREBP (SREBF)",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1655829"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-159418",
                    "label": "Recycling of bile acids and salts",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-159418"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-193368",
                        "label": "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol",
                        "weight": 10,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-193368"
                      },
                      {
                        "id": "R-HSA-193807",
                        "label": "Synthesis of bile acids and bile salts via 27-hydroxycholesterol",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-193807"
                      },
                      {
                        "id": "R-HSA-193775",
                        "label": "Synthesis of bile acids and bile salts via 24-hydroxycholesterol",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-193775"
                      }
                    ],
                    "id": "R-HSA-192105",
                    "label": "Synthesis of bile acids and bile salts",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-192105"
                  }
                ],
                "id": "R-HSA-194068",
                "label": "Bile acid and bile salt metabolism",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-194068"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-6807047",
                    "label": "Cholesterol biosynthesis via desmosterol",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6807047"
                  },
                  {
                    "id": "R-HSA-6807062",
                    "label": "Cholesterol biosynthesis via lathosterol",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6807062"
                  }
                ],
                "id": "R-HSA-191273",
                "label": "Cholesterol biosynthesis",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-191273"
              }
            ],
            "id": "R-HSA-8957322",
            "label": "Metabolism of steroids",
            "weight": 20,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8957322"
          },
          {
            "id": "R-HSA-8964572",
            "label": "Lipid particle organization",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8964572"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-389599",
                    "label": "Alpha-oxidation of phytanate",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-389599"
                  },
                  {
                    "id": "R-HSA-389887",
                    "label": "Beta-oxidation of pristanoyl-CoA",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-389887"
                  },
                  {
                    "id": "R-HSA-390247",
                    "label": "Beta-oxidation of very long chain fatty acids",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-390247"
                  }
                ],
                "id": "R-HSA-390918",
                "label": "Peroxisomal lipid metabolism",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-390918"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-75876",
                    "label": "Synthesis of very long-chain fatty acyl-CoAs",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-75876"
                  }
                ],
                "id": "R-HSA-75105",
                "label": "Fatty acyl-CoA biosynthesis",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-75105"
              },
              {
                "id": "R-HSA-200425",
                "label": "Import of palmitoyl-CoA into the mitochondrial matrix",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-200425"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-71032",
                    "label": "Propionyl-CoA catabolism",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-71032"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-77285",
                        "label": "Beta oxidation of myristoyl-CoA to lauroyl-CoA",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-77285"
                      },
                      {
                        "id": "R-HSA-77346",
                        "label": "Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-77346"
                      },
                      {
                        "id": "R-HSA-77348",
                        "label": "Beta oxidation of octanoyl-CoA to hexanoyl-CoA",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-77348"
                      },
                      {
                        "id": "R-HSA-77305",
                        "label": "Beta oxidation of palmitoyl-CoA to myristoyl-CoA",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-77305"
                      },
                      {
                        "id": "R-HSA-77310",
                        "label": "Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-77310"
                      },
                      {
                        "id": "R-HSA-77350",
                        "label": "Beta oxidation of hexanoyl-CoA to butanoyl-CoA",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-77350"
                      },
                      {
                        "id": "R-HSA-77352",
                        "label": "Beta oxidation of butanoyl-CoA to acetyl-CoA",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-77352"
                      }
                    ],
                    "id": "R-HSA-77286",
                    "label": "mitochondrial fatty acid beta-oxidation of saturated fatty acids",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-77286"
                  },
                  {
                    "id": "R-HSA-77288",
                    "label": "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-77288"
                  }
                ],
                "id": "R-HSA-77289",
                "label": "Mitochondrial Fatty Acid Beta-Oxidation",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-77289"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-2046106",
                    "label": "alpha-linolenic acid (ALA) metabolism",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2046106"
                  },
                  {
                    "id": "R-HSA-2046105",
                    "label": "Linoleic acid (LA) metabolism",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2046105"
                  }
                ],
                "id": "R-HSA-2046104",
                "label": "alpha-linolenic (omega3) and linoleic (omega6) acid metabolism",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2046104"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-2142770",
                    "label": "Synthesis of 15-eicosatetraenoic acid derivatives",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2142770"
                  },
                  {
                    "id": "R-HSA-2142816",
                    "label": "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2142816"
                  },
                  {
                    "id": "R-HSA-2142688",
                    "label": "Synthesis of 5-eicosatetraenoic acids",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2142688"
                  },
                  {
                    "id": "R-HSA-2142670",
                    "label": "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2142670"
                  },
                  {
                    "id": "R-HSA-2142712",
                    "label": "Synthesis of 12-eicosatetraenoic acid derivatives",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2142712"
                  },
                  {
                    "id": "R-HSA-2142696",
                    "label": "Synthesis of Hepoxilins (HX) and Trioxilins (TrX)",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2142696"
                  },
                  {
                    "id": "R-HSA-2142691",
                    "label": "Synthesis of Leukotrienes (LT) and Eoxins (EX)",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2142691"
                  },
                  {
                    "id": "R-HSA-2162123",
                    "label": "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2162123"
                  }
                ],
                "id": "R-HSA-2142753",
                "label": "Arachidonic acid metabolism",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2142753"
              }
            ],
            "id": "R-HSA-8978868",
            "label": "Fatty acid metabolism",
            "weight": 30,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8978868"
          },
          {
            "id": "R-HSA-8848584",
            "label": "Wax biosynthesis",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8848584"
          },
          {
            "groups": [
              {
                "id": "R-HSA-75109",
                "label": "Triglyceride biosynthesis",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-75109"
              },
              {
                "id": "R-HSA-163560",
                "label": "Triglyceride catabolism",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-163560"
              }
            ],
            "id": "R-HSA-8979227",
            "label": "Triglyceride metabolism",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8979227"
          },
          {
            "groups": [
              {
                "id": "R-HSA-1989781",
                "label": "PPARA activates gene expression",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1989781"
              }
            ],
            "id": "R-HSA-400206",
            "label": "Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-400206"
          },
          {
            "groups": [
              {
                "id": "R-HSA-77108",
                "label": "Utilization of Ketone Bodies",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-77108"
              },
              {
                "id": "R-HSA-77111",
                "label": "Synthesis of Ketone Bodies",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-77111"
              }
            ],
            "id": "R-HSA-74182",
            "label": "Ketone body metabolism",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-74182"
          },
          {
            "id": "R-HSA-75896",
            "label": "Plasmalogen biosynthesis",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-75896"
          },
          {
            "groups": [
              {
                "id": "R-HSA-1660662",
                "label": "Glycosphingolipid metabolism",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1660662"
              },
              {
                "id": "R-HSA-1660661",
                "label": "Sphingolipid de novo biosynthesis",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1660661"
              }
            ],
            "id": "R-HSA-428157",
            "label": "Sphingolipid metabolism",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-428157"
          }
        ],
        "id": "R-HSA-556833",
        "label": "Metabolism of lipids",
        "weight": 100,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-556833"
      },
      {
        "id": "R-HSA-1475029",
        "label": "Reversible hydration of carbon dioxide",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1475029"
      },
      {
        "groups": [
          {
            "id": "R-HSA-1855184",
            "label": "IPs transport between cytosol and ER lumen",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1855184"
          },
          {
            "id": "R-HSA-1855183",
            "label": "Synthesis of IP2, IP, and Ins in the cytosol",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1855183"
          },
          {
            "id": "R-HSA-1855170",
            "label": "IPs transport between nucleus and cytosol",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1855170"
          },
          {
            "id": "R-HSA-1855167",
            "label": "Synthesis of pyrophosphates in the cytosol",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1855167"
          },
          {
            "id": "R-HSA-1855156",
            "label": "IPs transport between ER lumen and nucleus",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1855156"
          },
          {
            "id": "R-HSA-1855215",
            "label": "IPs transport between ER lumen and cytosol",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1855215"
          },
          {
            "id": "R-HSA-1855204",
            "label": "Synthesis of IP3 and IP4 in the cytosol",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1855204"
          },
          {
            "id": "R-HSA-1855196",
            "label": "IP3 and IP4 transport between cytosol and nucleus",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1855196"
          },
          {
            "id": "R-HSA-1855192",
            "label": "IPs transport between nucleus and ER lumen",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1855192"
          },
          {
            "id": "R-HSA-1855191",
            "label": "Synthesis of IPs in the nucleus",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1855191"
          },
          {
            "id": "R-HSA-1855229",
            "label": "IP6 and IP7 transport between cytosol and nucleus",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1855229"
          },
          {
            "id": "R-HSA-1855231",
            "label": "Synthesis of IPs in the ER lumen",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1855231"
          }
        ],
        "id": "R-HSA-1483249",
        "label": "Inositol phosphate metabolism",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1483249"
      },
      {
        "groups": [
          {
            "id": "R-HSA-2395516",
            "label": "Electron transport from NADPH to Ferredoxin",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2395516"
          }
        ],
        "id": "R-HSA-1362409",
        "label": "Mitochondrial iron-sulfur cluster biogenesis",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1362409"
      },
      {
        "groups": [
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-6799198",
                    "label": "Complex I biogenesis",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6799198"
                  }
                ],
                "id": "R-HSA-611105",
                "label": "Respiratory electron transport",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-611105"
              },
              {
                "id": "R-HSA-163210",
                "label": "Formation of ATP by chemiosmotic coupling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-163210"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-167826",
                    "label": "The fatty acid cycling model",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-167826"
                  },
                  {
                    "id": "R-HSA-167827",
                    "label": "The proton buffering model",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-167827"
                  }
                ],
                "id": "R-HSA-166187",
                "label": "Mitochondrial Uncoupling Proteins",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-166187"
              }
            ],
            "id": "R-HSA-163200",
            "label": "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-163200"
          },
          {
            "groups": [
              {
                "id": "R-HSA-880009",
                "label": "Interconversion of 2-oxoglutarate and 2-hydroxyglutarate",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-880009"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-204174",
                    "label": "Regulation of pyruvate dehydrogenase (PDH) complex",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-204174"
                  }
                ],
                "id": "R-HSA-70268",
                "label": "Pyruvate metabolism",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-70268"
              },
              {
                "id": "R-HSA-71403",
                "label": "Citric acid cycle (TCA cycle)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-71403"
              }
            ],
            "id": "R-HSA-71406",
            "label": "Pyruvate metabolism and Citric Acid (TCA) cycle",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-71406"
          }
        ],
        "id": "R-HSA-1428517",
        "label": "The citric acid (TCA) cycle and respiratory electron transport",
        "weight": 20,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1428517"
      },
      {
        "groups": [
          {
            "id": "R-HSA-189483",
            "label": "Heme degradation",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-189483"
          },
          {
            "id": "R-HSA-189451",
            "label": "Heme biosynthesis",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-189451"
          }
        ],
        "id": "R-HSA-189445",
        "label": "Metabolism of porphyrins",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-189445"
      },
      {
        "groups": [
          {
            "id": "R-HSA-2161517",
            "label": "Abacavir transmembrane transport",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2161517"
          },
          {
            "id": "R-HSA-2161541",
            "label": "Abacavir metabolism",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2161541"
          }
        ],
        "id": "R-HSA-2161522",
        "label": "Abacavir transport and metabolism",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2161522"
      },
      {
        "groups": [
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-197264",
                    "label": "Nicotinamide salvaging",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-197264"
                  }
                ],
                "id": "R-HSA-196807",
                "label": "Nicotinate metabolism",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-196807"
              },
              {
                "id": "R-HSA-196757",
                "label": "Metabolism of folate and pterines",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-196757"
              },
              {
                "id": "R-HSA-196780",
                "label": "Biotin transport and metabolism",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-196780"
              },
              {
                "id": "R-HSA-196741",
                "label": "Cobalamin (Cbl, vitamin B12) transport and metabolism",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-196741"
              },
              {
                "id": "R-HSA-196819",
                "label": "Vitamin B1 (thiamin) metabolism",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-196819"
              },
              {
                "id": "R-HSA-196836",
                "label": "Vitamin C (ascorbate) metabolism",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-196836"
              },
              {
                "id": "R-HSA-196843",
                "label": "Vitamin B2 (riboflavin) metabolism",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-196843"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-196783",
                    "label": "Coenzyme A biosynthesis",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-196783"
                  }
                ],
                "id": "R-HSA-199220",
                "label": "Vitamin B5 (pantothenate) metabolism",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-199220"
              },
              {
                "id": "R-HSA-947581",
                "label": "Molybdenum cofactor biosynthesis",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-947581"
              },
              {
                "id": "R-HSA-964975",
                "label": "Vitamins B6 activation to pyridoxal phosphate",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-964975"
              }
            ],
            "id": "R-HSA-196849",
            "label": "Metabolism of water-soluble vitamins and cofactors",
            "weight": 20,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-196849"
          },
          {
            "groups": [
              {
                "id": "R-HSA-389542",
                "label": "NADPH regeneration",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-389542"
              },
              {
                "id": "R-HSA-1474151",
                "label": "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1474151"
              },
              {
                "id": "R-HSA-2142789",
                "label": "Ubiquinol biosynthesis",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2142789"
              }
            ],
            "id": "R-HSA-8978934",
            "label": "Metabolism of cofactors",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8978934"
          },
          {
            "groups": [
              {
                "id": "R-HSA-8877627",
                "label": "Vitamin E",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8877627"
              },
              {
                "id": "R-HSA-975634",
                "label": "Retinoid metabolism and transport",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-975634"
              },
              {
                "id": "R-HSA-6806664",
                "label": "Metabolism of vitamin K",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6806664"
              }
            ],
            "id": "R-HSA-6806667",
            "label": "Metabolism of fat-soluble vitamins",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6806667"
          }
        ],
        "id": "R-HSA-196854",
        "label": "Metabolism of vitamins and cofactors",
        "weight": 30,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-196854"
      },
      {
        "groups": [
          {
            "groups": [
              {
                "id": "R-HSA-1237112",
                "label": "Methionine salvage pathway",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1237112"
              },
              {
                "id": "R-HSA-70635",
                "label": "Urea cycle",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-70635"
              },
              {
                "id": "R-HSA-71288",
                "label": "Creatine metabolism",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-71288"
              },
              {
                "id": "R-HSA-350562",
                "label": "Regulation of ornithine decarboxylase (ODC)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-350562"
              },
              {
                "id": "R-HSA-351200",
                "label": "Interconversion of polyamines",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-351200"
              },
              {
                "id": "R-HSA-351143",
                "label": "Agmatine biosynthesis",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-351143"
              }
            ],
            "id": "R-HSA-351202",
            "label": "Metabolism of polyamines",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-351202"
          },
          {
            "id": "R-HSA-5662702",
            "label": "Melanin biosynthesis",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5662702"
          },
          {
            "groups": [
              {
                "id": "R-HSA-70921",
                "label": "Histidine catabolism",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-70921"
              },
              {
                "id": "R-HSA-71182",
                "label": "Phenylalanine and tyrosine catabolism",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-71182"
              },
              {
                "id": "R-HSA-71064",
                "label": "Lysine catabolism",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-71064"
              },
              {
                "id": "R-HSA-71240",
                "label": "Tryptophan catabolism",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-71240"
              },
              {
                "id": "R-HSA-70688",
                "label": "Proline catabolism",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-70688"
              }
            ],
            "id": "R-HSA-6788656",
            "label": "Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6788656"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-1614517",
                    "label": "Sulfide oxidation to sulfate",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1614517"
                  }
                ],
                "id": "R-HSA-1614558",
                "label": "Degradation of cysteine and homocysteine",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1614558"
              },
              {
                "id": "R-HSA-1614603",
                "label": "Cysteine formation from homocysteine",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1614603"
              },
              {
                "id": "R-HSA-1237112",
                "label": "Methionine salvage pathway",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1237112"
              }
            ],
            "id": "R-HSA-1614635",
            "label": "Sulfur amino acid metabolism",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1614635"
          },
          {
            "id": "R-HSA-6798163",
            "label": "Choline catabolism",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6798163"
          },
          {
            "groups": [
              {
                "id": "R-HSA-2408517",
                "label": "SeMet incorporation into proteins",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2408517"
              },
              {
                "id": "R-HSA-2408508",
                "label": "Metabolism of ingested SeMet, Sec, MeSec into H2Se",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2408508"
              },
              {
                "id": "R-HSA-2408499",
                "label": "Formation of selenosugars for excretion",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2408499"
              },
              {
                "id": "R-HSA-2408550",
                "label": "Metabolism of ingested H2SeO4 and H2SeO3 into H2Se",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2408550"
              },
              {
                "id": "R-HSA-2408552",
                "label": "Methylation of MeSeH for excretion",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2408552"
              },
              {
                "id": "R-HSA-2408557",
                "label": "Selenocysteine synthesis",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2408557"
              },
              {
                "id": "R-HSA-5263617",
                "label": "Metabolism of ingested MeSeO2H into MeSeH",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5263617"
              }
            ],
            "id": "R-HSA-2408522",
            "label": "Selenoamino acid metabolism",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2408522"
          },
          {
            "groups": [
              {
                "id": "R-HSA-6783984",
                "label": "Glycine degradation",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6783984"
              }
            ],
            "id": "R-HSA-389661",
            "label": "Glyoxylate metabolism and glycine degradation",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-389661"
          },
          {
            "id": "R-HSA-8849175",
            "label": "Threonine catabolism",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8849175"
          },
          {
            "groups": [
              {
                "id": "R-HSA-977347",
                "label": "Serine biosynthesis",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-977347"
              }
            ],
            "id": "R-HSA-70614",
            "label": "Amino acid synthesis and interconversion (transamination)",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-70614"
          },
          {
            "groups": [
              {
                "id": "R-HSA-71262",
                "label": "Carnitine synthesis",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-71262"
              }
            ],
            "id": "R-HSA-70895",
            "label": "Branched-chain amino acid catabolism",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-70895"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-350864",
                    "label": "Regulation of thyroid hormone activity",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-350864"
                  }
                ],
                "id": "R-HSA-209968",
                "label": "Thyroxine biosynthesis",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-209968"
              },
              {
                "id": "R-HSA-209905",
                "label": "Catecholamine biosynthesis",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-209905"
              },
              {
                "id": "R-HSA-209931",
                "label": "Serotonin and melatonin biosynthesis",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-209931"
              }
            ],
            "id": "R-HSA-209776",
            "label": "Amine-derived hormones",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-209776"
          }
        ],
        "id": "R-HSA-71291",
        "label": "Metabolism of amino acids and derivatives",
        "weight": 50,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-71291"
      },
      {
        "groups": [
          {
            "groups": [
              {
                "id": "R-HSA-70350",
                "label": "Fructose catabolism",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-70350"
              },
              {
                "id": "R-HSA-5652227",
                "label": "Fructose biosynthesis",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5652227"
              }
            ],
            "id": "R-HSA-5652084",
            "label": "Fructose metabolism",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5652084"
          },
          {
            "id": "R-HSA-5653890",
            "label": "Lactose synthesis",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5653890"
          },
          {
            "id": "R-HSA-5661270",
            "label": "Formation of xylulose-5-phosphate",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5661270"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-2022928",
                    "label": "HS-GAG biosynthesis",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2022928"
                  },
                  {
                    "id": "R-HSA-2024096",
                    "label": "HS-GAG degradation",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2024096"
                  },
                  {
                    "id": "R-HSA-1971475",
                    "label": "A tetrasaccharide linker sequence is required for GAG synthesis",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1971475"
                  }
                ],
                "id": "R-HSA-1638091",
                "label": "Heparan sulfate/heparin (HS-GAG) metabolism",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1638091"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-2022854",
                    "label": "Keratan sulfate biosynthesis",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2022854"
                  },
                  {
                    "id": "R-HSA-2022857",
                    "label": "Keratan sulfate degradation",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2022857"
                  }
                ],
                "id": "R-HSA-1638074",
                "label": "Keratan sulfate/keratin metabolism",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1638074"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-2022870",
                    "label": "Chondroitin sulfate biosynthesis",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2022870"
                  },
                  {
                    "id": "R-HSA-2022923",
                    "label": "Dermatan sulfate biosynthesis",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2022923"
                  },
                  {
                    "id": "R-HSA-2024101",
                    "label": "CS/DS degradation",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2024101"
                  },
                  {
                    "id": "R-HSA-1971475",
                    "label": "A tetrasaccharide linker sequence is required for GAG synthesis",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1971475"
                  }
                ],
                "id": "R-HSA-1793185",
                "label": "Chondroitin sulfate/dermatan sulfate metabolism",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1793185"
              },
              {
                "id": "R-HSA-174362",
                "label": "Transport and synthesis of PAPS",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-174362"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-2142850",
                    "label": "Hyaluronan biosynthesis and export",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2142850"
                  },
                  {
                    "id": "R-HSA-2160916",
                    "label": "Hyaluronan uptake and degradation",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2160916"
                  }
                ],
                "id": "R-HSA-2142845",
                "label": "Hyaluronan metabolism",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2142845"
              }
            ],
            "id": "R-HSA-1630316",
            "label": "Glycosaminoglycan metabolism",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1630316"
          },
          {
            "groups": [
              {
                "id": "R-HSA-3322077",
                "label": "Glycogen synthesis",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3322077"
              },
              {
                "id": "R-HSA-70221",
                "label": "Glycogen breakdown (glycogenolysis)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-70221"
              }
            ],
            "id": "R-HSA-8982491",
            "label": "Glycogen metabolism",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8982491"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-170822",
                    "label": "Regulation of Glucokinase by Glucokinase Regulatory Protein",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-170822"
                  }
                ],
                "id": "R-HSA-70171",
                "label": "Glycolysis",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-70171"
              },
              {
                "id": "R-HSA-70263",
                "label": "Gluconeogenesis",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-70263"
              }
            ],
            "id": "R-HSA-70326",
            "label": "Glucose metabolism",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-70326"
          },
          {
            "id": "R-HSA-70370",
            "label": "Galactose catabolism",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-70370"
          },
          {
            "groups": [
              {
                "id": "R-HSA-73843",
                "label": "5-Phosphoribose 1-diphosphate biosynthesis",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-73843"
              }
            ],
            "id": "R-HSA-71336",
            "label": "Pentose phosphate pathway",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-71336"
          },
          {
            "id": "R-HSA-8853383",
            "label": "Lysosomal oligosaccharide catabolism",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8853383"
          }
        ],
        "id": "R-HSA-71387",
        "label": "Metabolism of carbohydrates",
        "weight": 30,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-71387"
      },
      {
        "groups": [
          {
            "groups": [
              {
                "id": "R-HSA-203641",
                "label": "NOSTRIN mediated eNOS trafficking",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-203641"
              },
              {
                "id": "R-HSA-203615",
                "label": "eNOS activation",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-203615"
              },
              {
                "id": "R-HSA-203754",
                "label": "NOSIP mediated eNOS trafficking",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-203754"
              }
            ],
            "id": "R-HSA-203765",
            "label": "eNOS activation and regulation",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-203765"
          }
        ],
        "id": "R-HSA-202131",
        "label": "Metabolism of nitric oxide",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-202131"
      },
      {
        "id": "R-HSA-71737",
        "label": "Pyrophosphate hydrolysis",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-71737"
      },
      {
        "id": "R-HSA-2564830",
        "label": "Cytosolic iron-sulfur cluster assembly",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2564830"
      },
      {
        "groups": [
          {
            "groups": [
              {
                "id": "R-HSA-71384",
                "label": "Ethanol oxidation",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-71384"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-141333",
                    "label": "Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-141333"
                  },
                  {
                    "id": "R-HSA-141334",
                    "label": "PAOs oxidise polyamines to amines",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-141334"
                  }
                ],
                "id": "R-HSA-140179",
                "label": "Amine Oxidase reactions",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-140179"
              },
              {
                "id": "R-HSA-140180",
                "label": "COX reactions",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-140180"
              },
              {
                "groups": [
                  {
                    "groups": [
                      {
                        "id": "R-HSA-211994",
                        "label": "Sterols are 12-hydroxylated by CYP8B1",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-211994"
                      }
                    ],
                    "id": "R-HSA-211976",
                    "label": "Endogenous sterols",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-211976"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-211999",
                        "label": "CYP2E1 reactions",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-211999"
                      },
                      {
                        "id": "R-HSA-211957",
                        "label": "Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-211957"
                      }
                    ],
                    "id": "R-HSA-211981",
                    "label": "Xenobiotics",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-211981"
                  },
                  {
                    "id": "R-HSA-211979",
                    "label": "Eicosanoids",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-211979"
                  },
                  {
                    "id": "R-HSA-211935",
                    "label": "Fatty acids",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-211935"
                  },
                  {
                    "id": "R-HSA-211958",
                    "label": "Miscellaneous substrates",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-211958"
                  },
                  {
                    "id": "R-HSA-211916",
                    "label": "Vitamins",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-211916"
                  }
                ],
                "id": "R-HSA-211897",
                "label": "Cytochrome P450 - arranged by substrate type",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-211897"
              },
              {
                "id": "R-HSA-217271",
                "label": "FMO oxidises nucleophiles",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-217271"
              },
              {
                "id": "R-HSA-8937144",
                "label": "Aryl hydrocarbon receptor signalling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8937144"
              }
            ],
            "id": "R-HSA-211945",
            "label": "Phase I - Functionalization of compounds",
            "weight": 20,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-211945"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-173599",
                    "label": "Formation of the active cofactor, UDP-glucuronate",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-173599"
                  }
                ],
                "id": "R-HSA-156588",
                "label": "Glucuronidation",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-156588"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-174403",
                    "label": "Glutathione synthesis and recycling",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-174403"
                  }
                ],
                "id": "R-HSA-156590",
                "label": "Glutathione conjugation",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-156590"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-174362",
                    "label": "Transport and synthesis of PAPS",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-174362"
                  }
                ],
                "id": "R-HSA-156584",
                "label": "Cytosolic sulfonation of small molecules",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-156584"
              },
              {
                "groups": [
                  {
                    "groups": [
                      {
                        "id": "R-HSA-177162",
                        "label": "Conjugation of phenylacetate with glutamine",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-177162"
                      },
                      {
                        "id": "R-HSA-177135",
                        "label": "Conjugation of benzoate with glycine",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-177135"
                      },
                      {
                        "id": "R-HSA-177128",
                        "label": "Conjugation of salicylate with glycine",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-177128"
                      }
                    ],
                    "id": "R-HSA-159424",
                    "label": "Conjugation of carboxylic acids",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-159424"
                  }
                ],
                "id": "R-HSA-156587",
                "label": "Amino Acid conjugation",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-156587"
              },
              {
                "id": "R-HSA-156581",
                "label": "Methylation",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-156581"
              },
              {
                "id": "R-HSA-156582",
                "label": "Acetylation",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-156582"
              }
            ],
            "id": "R-HSA-156580",
            "label": "Phase II - Conjugation of compounds",
            "weight": 20,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-156580"
          },
          {
            "id": "R-HSA-5423646",
            "label": "Aflatoxin activation and detoxification",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5423646"
          }
        ],
        "id": "R-HSA-211859",
        "label": "Biological oxidations",
        "weight": 40,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-211859"
      }
    ],
    "id": "R-HSA-1430728",
    "label": "Metabolism",
    "weight": 250,
    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1430728"
  },
  {
    "groups": [
      {
        "groups": [
          {
            "groups": [
              {
                "id": "R-HSA-381771",
                "label": "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-381771"
              },
              {
                "id": "R-HSA-400511",
                "label": "Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-400511"
              }
            ],
            "id": "R-HSA-400508",
            "label": "Incretin synthesis, secretion, and inactivation",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-400508"
          },
          {
            "groups": [
              {
                "id": "R-HSA-209822",
                "label": "Glycoprotein hormones",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-209822"
              }
            ],
            "id": "R-HSA-209952",
            "label": "Peptide hormone biosynthesis",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-209952"
          },
          {
            "id": "R-HSA-422085",
            "label": "Synthesis, secretion, and deacylation of Ghrelin",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-422085"
          },
          {
            "id": "R-HSA-2022377",
            "label": "Metabolism of Angiotensinogen to Angiotensins",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2022377"
          },
          {
            "id": "R-HSA-264876",
            "label": "Insulin processing",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-264876"
          }
        ],
        "id": "R-HSA-2980736",
        "label": "Peptide hormone metabolism",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2980736"
      },
      {
        "id": "R-HSA-5676934",
        "label": "Protein repair",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5676934"
      },
      {
        "id": "R-HSA-5683826",
        "label": "Surfactant metabolism",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5683826"
      },
      {
        "groups": [
          {
            "groups": [
              {
                "id": "R-HSA-381038",
                "label": "XBP1(S) activates chaperone genes",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-381038"
              }
            ],
            "id": "R-HSA-381070",
            "label": "IRE1alpha activates chaperones",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-381070"
          },
          {
            "groups": [
              {
                "id": "R-HSA-380994",
                "label": "ATF4 activates genes",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-380994"
              }
            ],
            "id": "R-HSA-381042",
            "label": "PERK regulates gene expression",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-381042"
          },
          {
            "groups": [
              {
                "id": "R-HSA-381183",
                "label": "ATF6 (ATF6-alpha) activates chaperone genes",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-381183"
              }
            ],
            "id": "R-HSA-381033",
            "label": "ATF6 (ATF6-alpha) activates chaperones",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-381033"
          },
          {
            "id": "R-HSA-8874211",
            "label": "CREB3 factors activate genes",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8874211"
          }
        ],
        "id": "R-HSA-381119",
        "label": "Unfolded Protein Response (UPR)",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-381119"
      },
      {
        "id": "R-HSA-381426",
        "label": "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-381426"
      },
      {
        "id": "R-HSA-977225",
        "label": "Amyloid fiber formation",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-977225"
      },
      {
        "groups": [
          {
            "id": "R-HSA-389977",
            "label": "Post-chaperonin tubulin folding pathway",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-389977"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-389957",
                    "label": "Prefoldin mediated transfer of substrate  to CCT/TriC",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-389957"
                  },
                  {
                    "id": "R-HSA-389960",
                    "label": "Formation of tubulin folding intermediates by CCT/TriC",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-389960"
                  },
                  {
                    "id": "R-HSA-390450",
                    "label": "Folding of actin by CCT/TriC",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-390450"
                  }
                ],
                "id": "R-HSA-389958",
                "label": "Cooperation of Prefoldin and TriC/CCT  in actin and tubulin folding",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-389958"
              },
              {
                "id": "R-HSA-390471",
                "label": "Association of TriC/CCT with target proteins during biosynthesis",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-390471"
              },
              {
                "id": "R-HSA-6814122",
                "label": "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6814122"
              }
            ],
            "id": "R-HSA-390466",
            "label": "Chaperonin-mediated protein folding",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-390466"
          }
        ],
        "id": "R-HSA-391251",
        "label": "Protein folding",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-391251"
      },
      {
        "groups": [
          {
            "groups": [
              {
                "id": "R-HSA-379726",
                "label": "Mitochondrial tRNA aminoacylation",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-379726"
              },
              {
                "id": "R-HSA-379716",
                "label": "Cytosolic tRNA aminoacylation",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-379716"
              }
            ],
            "id": "R-HSA-379724",
            "label": "tRNA Aminoacylation",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-379724"
          },
          {
            "groups": [
              {
                "id": "R-HSA-5419276",
                "label": "Mitochondrial translation termination",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5419276"
              },
              {
                "id": "R-HSA-5368286",
                "label": "Mitochondrial translation initiation",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5368286"
              },
              {
                "id": "R-HSA-5389840",
                "label": "Mitochondrial translation elongation",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5389840"
              }
            ],
            "id": "R-HSA-5368287",
            "label": "Mitochondrial translation",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5368287"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-72689",
                    "label": "Formation of a pool of free 40S subunits",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-72689"
                  },
                  {
                    "id": "R-HSA-72695",
                    "label": "Formation of the ternary complex, and subsequently, the 43S complex",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-72695"
                  },
                  {
                    "id": "R-HSA-72702",
                    "label": "Ribosomal scanning and start codon recognition",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-72702"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-72649",
                        "label": "Translation initiation complex formation",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-72649"
                      }
                    ],
                    "id": "R-HSA-72662",
                    "label": "Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-72662"
                  },
                  {
                    "id": "R-HSA-72706",
                    "label": "GTP hydrolysis and joining of the 60S ribosomal subunit",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-72706"
                  },
                  {
                    "id": "R-HSA-72731",
                    "label": "Recycling of eIF2:GDP",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-72731"
                  }
                ],
                "id": "R-HSA-72737",
                "label": "Cap-dependent Translation Initiation",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-72737"
              },
              {
                "id": "R-HSA-156827",
                "label": "L13a-mediated translational silencing of Ceruloplasmin expression",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-156827"
              }
            ],
            "id": "R-HSA-72613",
            "label": "Eukaryotic Translation Initiation",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-72613"
          },
          {
            "id": "R-HSA-72764",
            "label": "Eukaryotic Translation Termination",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-72764"
          },
          {
            "groups": [
              {
                "id": "R-HSA-156902",
                "label": "Peptide chain elongation",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-156902"
              }
            ],
            "id": "R-HSA-156842",
            "label": "Eukaryotic Translation Elongation",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-156842"
          },
          {
            "id": "R-HSA-1799339",
            "label": "SRP-dependent cotranslational protein targeting to membrane",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1799339"
          }
        ],
        "id": "R-HSA-72766",
        "label": "Translation",
        "weight": 20,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-72766"
      },
      {
        "groups": [
          {
            "id": "R-HSA-8873719",
            "label": "RAB geranylgeranylation",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8873719"
          },
          {
            "id": "R-HSA-8876725",
            "label": "Protein methylation",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8876725"
          },
          {
            "groups": [
              {
                "id": "R-HSA-162699",
                "label": "Synthesis of dolichyl-phosphate mannose",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-162699"
              },
              {
                "id": "R-HSA-162791",
                "label": "Attachment of GPI anchor to uPAR",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-162791"
              },
              {
                "id": "R-HSA-162710",
                "label": "Synthesis of glycosylphosphatidylinositol (GPI)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-162710"
              }
            ],
            "id": "R-HSA-163125",
            "label": "Post-translational modification: synthesis of GPI-anchored proteins",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-163125"
          },
          {
            "groups": [
              {
                "id": "R-HSA-5358493",
                "label": "Synthesis of diphthamide-EEF2",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5358493"
              },
              {
                "id": "R-HSA-204626",
                "label": "Hypusine synthesis from eIF5A-lysine",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-204626"
              },
              {
                "id": "R-HSA-1663150",
                "label": "The activation of arylsulfatases",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1663150"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-159740",
                    "label": "Gamma-carboxylation of protein precursors",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-159740"
                  },
                  {
                    "id": "R-HSA-159763",
                    "label": "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-159763"
                  },
                  {
                    "id": "R-HSA-159782",
                    "label": "Removal of aminoterminal propeptides from gamma-carboxylated proteins",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-159782"
                  }
                ],
                "id": "R-HSA-159854",
                "label": "Gamma-carboxylation, transport, and amino-terminal cleavage of proteins",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-159854"
              }
            ],
            "id": "R-HSA-163841",
            "label": "Gamma carboxylation, hypusine formation and arylsulfatase activation",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-163841"
          },
          {
            "id": "R-HSA-8951664",
            "label": "Neddylation",
            "weight": 20,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8951664"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-4570464",
                    "label": "SUMOylation of RNA binding proteins",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4570464"
                  },
                  {
                    "id": "R-HSA-4655427",
                    "label": "SUMOylation of DNA methylation proteins",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4655427"
                  },
                  {
                    "id": "R-HSA-3232142",
                    "label": "SUMOylation of ubiquitinylation proteins",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3232142"
                  },
                  {
                    "id": "R-HSA-3232118",
                    "label": "SUMOylation of transcription factors",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3232118"
                  },
                  {
                    "id": "R-HSA-4085377",
                    "label": "SUMOylation of SUMOylation proteins",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4085377"
                  },
                  {
                    "id": "R-HSA-4090294",
                    "label": "SUMOylation of intracellular receptors",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4090294"
                  },
                  {
                    "id": "R-HSA-4551638",
                    "label": "SUMOylation of chromatin organization proteins",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4551638"
                  },
                  {
                    "id": "R-HSA-4615885",
                    "label": "SUMOylation of DNA replication proteins",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4615885"
                  },
                  {
                    "id": "R-HSA-3108214",
                    "label": "SUMOylation of DNA damage response and repair proteins",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3108214"
                  },
                  {
                    "id": "R-HSA-3899300",
                    "label": "SUMOylation of transcription cofactors",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3899300"
                  },
                  {
                    "id": "R-HSA-4755510",
                    "label": "SUMOylation of immune response proteins",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4755510"
                  }
                ],
                "id": "R-HSA-3108232",
                "label": "SUMO E3 ligases SUMOylate target proteins",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3108232"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-3065679",
                    "label": "SUMO is proteolytically processed",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3065679"
                  },
                  {
                    "id": "R-HSA-3065678",
                    "label": "SUMO is transferred from E1 to E2 (UBE2I, UBC9)",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3065678"
                  },
                  {
                    "id": "R-HSA-3065676",
                    "label": "SUMO is conjugated to E1 (UBA2:SAE1)",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3065676"
                  }
                ],
                "id": "R-HSA-3215018",
                "label": "Processing and activation of SUMO",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3215018"
              }
            ],
            "id": "R-HSA-2990846",
            "label": "SUMOylation",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2990846"
          },
          {
            "id": "R-HSA-8955332",
            "label": "Carboxyterminal post-translational modifications of tubulin",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8955332"
          },
          {
            "id": "R-HSA-8957275",
            "label": "Post-translational protein phosphorylation",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8957275"
          },
          {
            "groups": [
              {
                "id": "R-HSA-5689896",
                "label": "Ovarian tumor domain proteases",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5689896"
              },
              {
                "id": "R-HSA-5689877",
                "label": "Josephin domain DUBs",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5689877"
              },
              {
                "id": "R-HSA-5689880",
                "label": "Ub-specific processing proteases",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5689880"
              },
              {
                "id": "R-HSA-5689901",
                "label": "Metalloprotease DUBs",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5689901"
              },
              {
                "id": "R-HSA-5689603",
                "label": "UCH proteinases",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5689603"
              }
            ],
            "id": "R-HSA-5688426",
            "label": "Deubiquitination",
            "weight": 20,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5688426"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "groups": [
                      {
                        "id": "R-HSA-901032",
                        "label": "ER Quality Control Compartment (ERQC)",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-901032"
                      }
                    ],
                    "id": "R-HSA-901042",
                    "label": "Calnexin/calreticulin cycle",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-901042"
                  }
                ],
                "id": "R-HSA-532668",
                "label": "N-glycan trimming in the ER and Calnexin/Calreticulin cycle",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-532668"
              },
              {
                "groups": [
                  {
                    "groups": [
                      {
                        "id": "R-HSA-964827",
                        "label": "Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-964827"
                      }
                    ],
                    "id": "R-HSA-964739",
                    "label": "N-glycan trimming and elongation in the cis-Golgi",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-964739"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-975577",
                        "label": "N-Glycan antennae elongation",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-975577"
                      },
                      {
                        "id": "R-HSA-975578",
                        "label": "Reactions specific to the complex N-glycan synthesis pathway",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-975578"
                      },
                      {
                        "id": "R-HSA-975574",
                        "label": "Reactions specific to the hybrid N-glycan synthesis pathway",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-975574"
                      }
                    ],
                    "id": "R-HSA-975576",
                    "label": "N-glycan antennae elongation in the medial/trans-Golgi",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-975576"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-6807878",
                        "label": "COPI-mediated anterograde transport",
                        "weight": 10,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6807878"
                      },
                      {
                        "id": "R-HSA-5694530",
                        "label": "Cargo concentration in the ER",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5694530"
                      },
                      {
                        "id": "R-HSA-204005",
                        "label": "COPII-mediated vesicle transport",
                        "weight": 10,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-204005"
                      }
                    ],
                    "id": "R-HSA-199977",
                    "label": "ER to Golgi Anterograde Transport",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-199977"
                  }
                ],
                "id": "R-HSA-948021",
                "label": "Transport to the Golgi and subsequent modification",
                "weight": 20,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-948021"
              },
              {
                "groups": [
                  {
                    "groups": [
                      {
                        "id": "R-HSA-4085001",
                        "label": "Sialic acid metabolism",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4085001"
                      },
                      {
                        "id": "R-HSA-480985",
                        "label": "Synthesis of dolichyl-phosphate-glucose",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-480985"
                      },
                      {
                        "id": "R-HSA-162699",
                        "label": "Synthesis of dolichyl-phosphate mannose",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-162699"
                      },
                      {
                        "id": "R-HSA-6787639",
                        "label": "GDP-fucose biosynthesis",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6787639"
                      },
                      {
                        "id": "R-HSA-446205",
                        "label": "Synthesis of GDP-mannose",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-446205"
                      },
                      {
                        "id": "R-HSA-446210",
                        "label": "Synthesis of UDP-N-acetyl-glucosamine",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-446210"
                      },
                      {
                        "id": "R-HSA-446199",
                        "label": "Synthesis of Dolichyl-phosphate",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-446199"
                      }
                    ],
                    "id": "R-HSA-446219",
                    "label": "Synthesis of substrates in N-glycan biosythesis",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-446219"
                  }
                ],
                "id": "R-HSA-446193",
                "label": "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-446193"
              }
            ],
            "id": "R-HSA-446203",
            "label": "Asparagine N-linked glycosylation",
            "weight": 30,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-446203"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-977068",
                    "label": "Termination of O-glycan biosynthesis",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-977068"
                  }
                ],
                "id": "R-HSA-913709",
                "label": "O-linked glycosylation of mucins",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-913709"
              },
              {
                "id": "R-HSA-5173214",
                "label": "O-glycosylation of TSR domain-containing proteins",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5173214"
              }
            ],
            "id": "R-HSA-5173105",
            "label": "O-linked glycosylation",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5173105"
          },
          {
            "groups": [
              {
                "id": "R-HSA-8866654",
                "label": "E3 ubiquitin ligases ubiquitinate target proteins",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8866654"
              },
              {
                "id": "R-HSA-8866652",
                "label": "Synthesis of active ubiquitin: roles of E1 and E2 enzymes",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8866652"
              }
            ],
            "id": "R-HSA-8852135",
            "label": "Protein ubiquitination",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8852135"
          }
        ],
        "id": "R-HSA-597592",
        "label": "Post-translational protein modification",
        "weight": 110,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-597592"
      }
    ],
    "id": "R-HSA-392499",
    "label": "Metabolism of proteins",
    "weight": 170,
    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-392499"
  },
  {
    "groups": [
      {
        "groups": [
          {
            "id": "R-HSA-450385",
            "label": "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450385"
          },
          {
            "id": "R-HSA-450408",
            "label": "AUF1 (hnRNP D0) binds and destabilizes mRNA",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450408"
          },
          {
            "id": "R-HSA-450604",
            "label": "KSRP (KHSRP) binds and destabilizes mRNA",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450604"
          },
          {
            "id": "R-HSA-450520",
            "label": "HuR (ELAVL1) binds and stabilizes mRNA",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450520"
          },
          {
            "id": "R-HSA-450513",
            "label": "Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450513"
          }
        ],
        "id": "R-HSA-450531",
        "label": "Regulation of mRNA stability by proteins that bind AU-rich elements",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-450531"
      },
      {
        "groups": [
          {
            "id": "R-HSA-191859",
            "label": "snRNP Assembly",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-191859"
          }
        ],
        "id": "R-HSA-194441",
        "label": "Metabolism of non-coding RNA",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-194441"
      },
      {
        "groups": [
          {
            "groups": [
              {
                "id": "R-HSA-72163",
                "label": "mRNA Splicing - Major Pathway",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-72163"
              },
              {
                "id": "R-HSA-72165",
                "label": "mRNA Splicing - Minor Pathway",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-72165"
              }
            ],
            "id": "R-HSA-72172",
            "label": "mRNA Splicing",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-72172"
          },
          {
            "id": "R-HSA-72187",
            "label": "mRNA 3'-end processing",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-72187"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-159231",
                    "label": "Transport of Mature mRNA Derived from an Intronless Transcript",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-159231"
                  },
                  {
                    "id": "R-HSA-159230",
                    "label": "Transport of the SLBP Dependant Mature mRNA",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-159230"
                  },
                  {
                    "id": "R-HSA-159227",
                    "label": "Transport of the SLBP independent Mature mRNA",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-159227"
                  }
                ],
                "id": "R-HSA-159234",
                "label": "Transport of Mature mRNAs Derived from Intronless Transcripts",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-159234"
              },
              {
                "id": "R-HSA-159236",
                "label": "Transport of Mature mRNA derived from an Intron-Containing Transcript",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-159236"
              }
            ],
            "id": "R-HSA-72202",
            "label": "Transport of Mature Transcript to Cytoplasm",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-72202"
          }
        ],
        "id": "R-HSA-72203",
        "label": "Processing of Capped Intron-Containing Pre-mRNA",
        "weight": 20,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-72203"
      },
      {
        "id": "R-HSA-72086",
        "label": "mRNA Capping",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-72086"
      },
      {
        "groups": [
          {
            "groups": [
              {
                "id": "R-HSA-6790901",
                "label": "rRNA modification in the nucleus and cytosol",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6790901"
              },
              {
                "id": "R-HSA-6791226",
                "label": "Major pathway of rRNA processing in the nucleolus and cytosol",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6791226"
              }
            ],
            "id": "R-HSA-8868773",
            "label": "rRNA processing in the nucleus and cytosol",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8868773"
          },
          {
            "groups": [
              {
                "id": "R-HSA-6793080",
                "label": "rRNA modification in the mitochondrion",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6793080"
              }
            ],
            "id": "R-HSA-8868766",
            "label": "rRNA processing in the mitochondrion",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8868766"
          }
        ],
        "id": "R-HSA-72312",
        "label": "rRNA processing",
        "weight": 20,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-72312"
      },
      {
        "groups": [
          {
            "groups": [
              {
                "id": "R-HSA-6782861",
                "label": "Synthesis of wybutosine at G37 of tRNA(Phe)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6782861"
              }
            ],
            "id": "R-HSA-6782315",
            "label": "tRNA modification in the nucleus and cytosol",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6782315"
          },
          {
            "id": "R-HSA-6784531",
            "label": "tRNA processing in the nucleus",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6784531"
          },
          {
            "id": "R-HSA-6785470",
            "label": "tRNA processing in the mitochondrion",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6785470"
          },
          {
            "id": "R-HSA-6787450",
            "label": "tRNA modification in the mitochondrion",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6787450"
          }
        ],
        "id": "R-HSA-72306",
        "label": "tRNA processing",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-72306"
      },
      {
        "groups": [
          {
            "id": "R-HSA-111367",
            "label": "SLBP independent Processing of Histone Pre-mRNAs",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-111367"
          },
          {
            "id": "R-HSA-77588",
            "label": "SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-77588"
          },
          {
            "id": "R-HSA-77595",
            "label": "Processing of Intronless Pre-mRNAs",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-77595"
          }
        ],
        "id": "R-HSA-75067",
        "label": "Processing of Capped Intronless Pre-mRNA",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-75067"
      },
      {
        "groups": [
          {
            "groups": [
              {
                "id": "R-HSA-75094",
                "label": "Formation of the Editosome",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-75094"
              }
            ],
            "id": "R-HSA-72200",
            "label": "mRNA Editing: C to U Conversion",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-72200"
          },
          {
            "groups": [
              {
                "id": "R-HSA-75102",
                "label": "C6 deamination of adenosine",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-75102"
              },
              {
                "id": "R-HSA-77042",
                "label": "Formation of editosomes by ADAR proteins",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-77042"
              }
            ],
            "id": "R-HSA-75064",
            "label": "mRNA Editing: A to I Conversion",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-75064"
          }
        ],
        "id": "R-HSA-75072",
        "label": "mRNA Editing",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-75072"
      },
      {
        "groups": [
          {
            "id": "R-HSA-975957",
            "label": "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-975957"
          },
          {
            "id": "R-HSA-975956",
            "label": "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-975956"
          }
        ],
        "id": "R-HSA-927802",
        "label": "Nonsense-Mediated Decay (NMD)",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-927802"
      },
      {
        "id": "R-HSA-428359",
        "label": "Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-428359"
      },
      {
        "groups": [
          {
            "id": "R-HSA-430039",
            "label": "mRNA decay by 5' to 3' exoribonuclease",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-430039"
          },
          {
            "id": "R-HSA-429947",
            "label": "Deadenylation of mRNA",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-429947"
          },
          {
            "id": "R-HSA-429958",
            "label": "mRNA decay by 3' to 5' exoribonuclease",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-429958"
          }
        ],
        "id": "R-HSA-429914",
        "label": "Deadenylation-dependent mRNA decay",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-429914"
      }
    ],
    "id": "R-HSA-8953854",
    "label": "Metabolism of RNA",
    "weight": 60,
    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8953854"
  },
  {
    "groups": [
      {
        "id": "R-HSA-8934903",
        "label": "Receptor Mediated Mitophagy",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8934903"
      },
      {
        "id": "R-HSA-5205685",
        "label": "Pink/Parkin Mediated Mitophagy",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5205685"
      }
    ],
    "id": "R-HSA-5205647",
    "label": "Mitophagy",
    "weight": 9,
    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5205647"
  },
  {
    "groups": [
      {
        "id": "R-HSA-445355",
        "label": "Smooth Muscle Contraction",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-445355"
      },
      {
        "id": "R-HSA-390522",
        "label": "Striated Muscle Contraction",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-390522"
      },
      {
        "groups": [
          {
            "id": "R-HSA-5578768",
            "label": "Physiological factors",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5578768"
          },
          {
            "id": "R-HSA-5578775",
            "label": "Ion homeostasis",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5578775"
          },
          {
            "id": "R-HSA-5576894",
            "label": "Phase 1 - inactivation of fast Na+ channels",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5576894"
          },
          {
            "id": "R-HSA-5576893",
            "label": "Phase 2 - plateau phase",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5576893"
          },
          {
            "id": "R-HSA-5576892",
            "label": "Phase 0 - rapid depolarisation",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5576892"
          },
          {
            "id": "R-HSA-5576886",
            "label": "Phase 4 - resting membrane potential",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5576886"
          },
          {
            "id": "R-HSA-5576890",
            "label": "Phase 3 - rapid repolarisation",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5576890"
          }
        ],
        "id": "R-HSA-5576891",
        "label": "Cardiac conduction",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5576891"
      }
    ],
    "id": "R-HSA-397014",
    "label": "Muscle contraction",
    "weight": 20,
    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-397014"
  },
  {
    "groups": [
      {
        "groups": [
          {
            "id": "R-HSA-6794361",
            "label": "Neurexins and neuroligins",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6794361"
          },
          {
            "id": "R-HSA-388844",
            "label": "Receptor-type tyrosine-protein phosphatases",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-388844"
          },
          {
            "id": "R-HSA-8849932",
            "label": "Synaptic adhesion-like molecules",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8849932"
          }
        ],
        "id": "R-HSA-6794362",
        "label": "Protein-protein interactions at synapses",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6794362"
      },
      {
        "groups": [
          {
            "id": "R-HSA-112303",
            "label": "Electric Transmission Across Gap Junctions",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-112303"
          }
        ],
        "id": "R-HSA-112307",
        "label": "Transmission across Electrical Synapses ",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-112307"
      },
      {
        "groups": [
          {
            "groups": [
              {
                "id": "R-HSA-210455",
                "label": "Astrocytic Glutamate-Glutamine Uptake And Metabolism",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-210455"
              }
            ],
            "id": "R-HSA-112313",
            "label": "Neurotransmitter uptake and metabolism In glial cells",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-112313"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-500657",
                    "label": "Presynaptic function of Kainate receptors",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-500657"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-451307",
                        "label": "Activation of Na-permeable kainate receptors",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-451307"
                      },
                      {
                        "id": "R-HSA-451308",
                        "label": "Activation of Ca-permeable Kainate Receptor",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-451308"
                      }
                    ],
                    "id": "R-HSA-451306",
                    "label": "Ionotropic activity of kainate receptors",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-451306"
                  }
                ],
                "id": "R-HSA-451326",
                "label": "Activation of kainate receptors upon glutamate binding",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-451326"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-977442",
                    "label": "GABA A (rho) receptor activation",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-977442"
                  },
                  {
                    "id": "R-HSA-977441",
                    "label": "GABA A receptor activation",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-977441"
                  },
                  {
                    "groups": [
                      {
                        "groups": [
                          {
                            "groups": [
                              {
                                "id": "R-HSA-170670",
                                "label": "Adenylate cyclase inhibitory pathway",
                                "weight": 9,
                                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-170670"
                              }
                            ],
                            "id": "R-HSA-997269",
                            "label": "Inhibition of adenylate cyclase pathway",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-997269"
                          },
                          {
                            "id": "R-HSA-997272",
                            "label": "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-997272"
                          }
                        ],
                        "id": "R-HSA-991365",
                        "label": "Activation of GABAB receptors",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-991365"
                      }
                    ],
                    "id": "R-HSA-977444",
                    "label": "GABA B receptor activation",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-977444"
                  }
                ],
                "id": "R-HSA-977443",
                "label": "GABA receptor activation",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-977443"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-399710",
                    "label": "Activation of AMPA receptors",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-399710"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-416993",
                        "label": "Trafficking of GluR2-containing AMPA receptors",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-416993"
                      }
                    ],
                    "id": "R-HSA-399719",
                    "label": "Trafficking of AMPA receptors",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-399719"
                  }
                ],
                "id": "R-HSA-399721",
                "label": "Glutamate binding, activation of AMPA receptors and synaptic plasticity",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-399721"
              },
              {
                "groups": [
                  {
                    "groups": [
                      {
                        "id": "R-HSA-9620244",
                        "label": "Long-term potentiation",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9620244"
                      },
                      {
                        "groups": [
                          {
                            "id": "R-HSA-442982",
                            "label": "Ras activation upon Ca2+ influx through NMDA receptor",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-442982"
                          },
                          {
                            "id": "R-HSA-444257",
                            "label": "RSK activation",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-444257"
                          }
                        ],
                        "id": "R-HSA-442742",
                        "label": "CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-442742"
                      },
                      {
                        "id": "R-HSA-442720",
                        "label": "CREB1 phosphorylation through the activation of Adenylate Cyclase",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-442720"
                      },
                      {
                        "id": "R-HSA-442729",
                        "label": "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-442729"
                      },
                      {
                        "id": "R-HSA-9619229",
                        "label": "Activation of RAC1 downstream of NMDARs",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9619229"
                      },
                      {
                        "id": "R-HSA-9619483",
                        "label": "Activation of AMPK downstream of NMDARs",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9619483"
                      }
                    ],
                    "id": "R-HSA-438064",
                    "label": "Post NMDA receptor activation events",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-438064"
                  },
                  {
                    "id": "R-HSA-438066",
                    "label": "Unblocking of NMDA receptors, glutamate binding and activation",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-438066"
                  },
                  {
                    "id": "R-HSA-9617324",
                    "label": "Negative regulation of NMDA receptor-mediated neuronal transmission",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9617324"
                  }
                ],
                "id": "R-HSA-442755",
                "label": "Activation of NMDA receptors and postsynaptic events",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-442755"
              },
              {
                "groups": [
                  {
                    "groups": [
                      {
                        "groups": [
                          {
                            "id": "R-HSA-629597",
                            "label": "Highly calcium permeable nicotinic acetylcholine receptors",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-629597"
                          },
                          {
                            "id": "R-HSA-629587",
                            "label": "Highly sodium permeable acetylcholine nicotinic receptors",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-629587"
                          }
                        ],
                        "id": "R-HSA-622323",
                        "label": "Presynaptic nicotinic acetylcholine receptors",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-622323"
                      },
                      {
                        "groups": [
                          {
                            "id": "R-HSA-629587",
                            "label": "Highly sodium permeable acetylcholine nicotinic receptors",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-629587"
                          },
                          {
                            "id": "R-HSA-629594",
                            "label": "Highly calcium permeable postsynaptic nicotinic acetylcholine receptors",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-629594"
                          }
                        ],
                        "id": "R-HSA-622327",
                        "label": "Postsynaptic nicotinic acetylcholine receptors",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-622327"
                      }
                    ],
                    "id": "R-HSA-629602",
                    "label": "Activation of Nicotinic Acetylcholine Receptors",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-629602"
                  }
                ],
                "id": "R-HSA-181431",
                "label": "Acetylcholine binding and downstream events",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-181431"
              }
            ],
            "id": "R-HSA-112314",
            "label": "Neurotransmitter receptors and postsynaptic signal transmission",
            "weight": 20,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-112314"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-379398",
                    "label": "Enzymatic degradation of Dopamine by monoamine oxidase",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-379398"
                  },
                  {
                    "id": "R-HSA-379397",
                    "label": "Enzymatic degradation of dopamine by COMT",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-379397"
                  }
                ],
                "id": "R-HSA-379401",
                "label": "Dopamine clearance from the synaptic cleft",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-379401"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-380612",
                    "label": "Metabolism of serotonin",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-380612"
                  }
                ],
                "id": "R-HSA-380615",
                "label": "Serotonin clearance from the synaptic cleft",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-380615"
              }
            ],
            "id": "R-HSA-112311",
            "label": "Neurotransmitter clearance",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-112311"
          },
          {
            "groups": [
              {
                "id": "R-HSA-264642",
                "label": "Acetylcholine Neurotransmitter Release Cycle",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-264642"
              },
              {
                "id": "R-HSA-210500",
                "label": "Glutamate Neurotransmitter Release Cycle",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-210500"
              },
              {
                "id": "R-HSA-212676",
                "label": "Dopamine Neurotransmitter Release Cycle",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-212676"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-916853",
                    "label": "Degradation of GABA",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-916853"
                  },
                  {
                    "id": "R-HSA-888568",
                    "label": "GABA synthesis",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-888568"
                  },
                  {
                    "id": "R-HSA-888593",
                    "label": "Reuptake of GABA",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-888593"
                  }
                ],
                "id": "R-HSA-888590",
                "label": "GABA synthesis, release, reuptake and degradation",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-888590"
              },
              {
                "id": "R-HSA-181429",
                "label": "Serotonin Neurotransmitter Release Cycle",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-181429"
              },
              {
                "id": "R-HSA-181430",
                "label": "Norepinephrine Neurotransmitter Release Cycle",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-181430"
              }
            ],
            "id": "R-HSA-112310",
            "label": "Neurotransmitter release cycle",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-112310"
          },
          {
            "id": "R-HSA-112308",
            "label": "Presynaptic depolarization and calcium channel opening",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-112308"
          }
        ],
        "id": "R-HSA-112315",
        "label": "Transmission across Chemical Synapses",
        "weight": 20,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-112315"
      },
      {
        "groups": [
          {
            "id": "R-HSA-1296072",
            "label": "Voltage gated Potassium channels",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1296072"
          },
          {
            "groups": [
              {
                "id": "R-HSA-1296025",
                "label": "ATP sensitive Potassium channels",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1296025"
              },
              {
                "id": "R-HSA-1296067",
                "label": "Potassium transport channels",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1296067"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-1296041",
                    "label": "Activation of G protein gated Potassium channels",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1296041"
                  }
                ],
                "id": "R-HSA-1296059",
                "label": "G protein gated Potassium channels",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1296059"
              },
              {
                "id": "R-HSA-1296053",
                "label": "Classical Kir channels",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1296053"
              }
            ],
            "id": "R-HSA-1296065",
            "label": "Inwardly rectifying K+ channels",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1296065"
          },
          {
            "id": "R-HSA-1296061",
            "label": "HCN channels",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1296061"
          },
          {
            "id": "R-HSA-1296052",
            "label": "Ca2+ activated K+ channels",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1296052"
          },
          {
            "groups": [
              {
                "id": "R-HSA-1299344",
                "label": "TWIK-related spinal cord K+ channel (TRESK)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1299344"
              },
              {
                "id": "R-HSA-1299316",
                "label": "TWIK-releated acid-sensitive K+ channel (TASK)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1299316"
              },
              {
                "id": "R-HSA-1299308",
                "label": "Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1299308"
              },
              {
                "id": "R-HSA-1299287",
                "label": "Tandem pore domain halothane-inhibited K+ channel (THIK)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1299287"
              },
              {
                "id": "R-HSA-1299361",
                "label": "TWIK-related alkaline pH activated K+ channel (TALK)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1299361"
              },
              {
                "id": "R-HSA-1299503",
                "label": "TWIK related potassium channel (TREK)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1299503"
              }
            ],
            "id": "R-HSA-1296346",
            "label": "Tandem pore domain potassium channels",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1296346"
          }
        ],
        "id": "R-HSA-1296071",
        "label": "Potassium Channels",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1296071"
      }
    ],
    "id": "R-HSA-112316",
    "label": "Neuronal System",
    "weight": 30,
    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-112316"
  },
  {
    "groups": [
      {
        "groups": [
          {
            "id": "R-HSA-8949613",
            "label": "Cristae formation",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8949613"
          },
          {
            "id": "R-HSA-2151201",
            "label": "Transcriptional activation of mitochondrial biogenesis",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2151201"
          },
          {
            "id": "R-HSA-2151209",
            "label": "Activation of PPARGC1A (PGC-1alpha) by phosphorylation",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2151209"
          }
        ],
        "id": "R-HSA-1592230",
        "label": "Mitochondrial biogenesis",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1592230"
      },
      {
        "groups": [
          {
            "id": "R-HSA-5620924",
            "label": "Intraflagellar transport",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5620924"
          },
          {
            "id": "R-HSA-5620912",
            "label": "Anchoring of the basal body to the plasma membrane",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5620912"
          },
          {
            "groups": [
              {
                "id": "R-HSA-5620916",
                "label": "VxPx cargo-targeting to cilium",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5620916"
              },
              {
                "id": "R-HSA-5620922",
                "label": "BBSome-mediated cargo-targeting to cilium",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5620922"
              },
              {
                "id": "R-HSA-5624138",
                "label": "Trafficking of myristoylated proteins to the cilium",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5624138"
              },
              {
                "id": "R-HSA-5624958",
                "label": "ARL13B-mediated ciliary trafficking of INPP5E",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5624958"
              }
            ],
            "id": "R-HSA-5620920",
            "label": "Cargo trafficking to the periciliary membrane",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5620920"
          }
        ],
        "id": "R-HSA-5617833",
        "label": "Cilium Assembly",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5617833"
      }
    ],
    "id": "R-HSA-1852241",
    "label": "Organelle biogenesis and maintenance",
    "weight": 20,
    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1852241"
  },
  {
    "groups": [
      {
        "groups": [
          {
            "groups": [
              {
                "id": "R-HSA-211728",
                "label": "Regulation of PAK-2p34 activity by PS-GAP/RHG10",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-211728"
              },
              {
                "id": "R-HSA-211733",
                "label": "Regulation of activated PAK-2p34 by proteasome mediated degradation",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-211733"
              }
            ],
            "id": "R-HSA-169911",
            "label": "Regulation of Apoptosis",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-169911"
          },
          {
            "groups": [
              {
                "id": "R-HSA-111453",
                "label": "BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-111453"
              },
              {
                "id": "R-HSA-111452",
                "label": "Activation and oligomerization of BAK protein",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-111452"
              },
              {
                "groups": [
                  {
                    "groups": [
                      {
                        "id": "R-HSA-111459",
                        "label": "Activation of caspases through apoptosome-mediated cleavage",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-111459"
                      },
                      {
                        "groups": [
                          {
                            "id": "R-HSA-9627069",
                            "label": "Regulation of the apoptosome activity",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9627069"
                          }
                        ],
                        "id": "R-HSA-111458",
                        "label": "Formation of apoptosome",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-111458"
                      }
                    ],
                    "id": "R-HSA-111461",
                    "label": "Cytochrome c-mediated apoptotic response",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-111461"
                  },
                  {
                    "id": "R-HSA-111457",
                    "label": "Release of apoptotic factors from the mitochondria",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-111457"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-111463",
                        "label": "SMAC (DIABLO) binds to IAPs ",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-111463"
                      },
                      {
                        "id": "R-HSA-111464",
                        "label": "SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-111464"
                      }
                    ],
                    "id": "R-HSA-111469",
                    "label": "SMAC, XIAP-regulated apoptotic response",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-111469"
                  }
                ],
                "id": "R-HSA-111471",
                "label": "Apoptotic factor-mediated response",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-111471"
              },
              {
                "id": "R-HSA-114294",
                "label": "Activation, translocation and oligomerization of BAX",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-114294"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-139910",
                    "label": "Activation of BMF and translocation to mitochondria",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-139910"
                  },
                  {
                    "id": "R-HSA-139915",
                    "label": "Activation of PUMA and translocation to mitochondria",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-139915"
                  },
                  {
                    "id": "R-HSA-111448",
                    "label": "Activation of NOXA and translocation to mitochondria",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-111448"
                  },
                  {
                    "id": "R-HSA-111447",
                    "label": "Activation of BAD and translocation to mitochondria ",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-111447"
                  },
                  {
                    "id": "R-HSA-111446",
                    "label": "Activation of BIM and translocation to mitochondria ",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-111446"
                  }
                ],
                "id": "R-HSA-114452",
                "label": "Activation of BH3-only proteins",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-114452"
              },
              {
                "id": "R-HSA-75108",
                "label": "Activation, myristolyation of BID and translocation to mitochondria",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-75108"
              }
            ],
            "id": "R-HSA-109606",
            "label": "Intrinsic Pathway for Apoptosis",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-109606"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-69416",
                    "label": "Dimerization of procaspase-8",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-69416"
                  },
                  {
                    "id": "R-HSA-3371378",
                    "label": "Regulation by c-FLIP",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3371378"
                  }
                ],
                "id": "R-HSA-140534",
                "label": "Caspase activation via Death Receptors in the presence of ligand",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-140534"
              },
              {
                "id": "R-HSA-418889",
                "label": "Caspase activation via Dependence Receptors in the absence of ligand",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-418889"
              }
            ],
            "id": "R-HSA-5357769",
            "label": "Caspase activation via extrinsic apoptotic signalling pathway",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5357769"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-351906",
                    "label": "Apoptotic cleavage of cell adhesion  proteins",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-351906"
                  },
                  {
                    "id": "R-HSA-352238",
                    "label": "Breakdown of the nuclear lamina",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-352238"
                  },
                  {
                    "id": "R-HSA-264870",
                    "label": "Caspase-mediated cleavage of cytoskeletal proteins",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-264870"
                  }
                ],
                "id": "R-HSA-111465",
                "label": "Apoptotic cleavage of cellular proteins",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-111465"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-211227",
                    "label": "Activation of DNA fragmentation factor",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-211227"
                  }
                ],
                "id": "R-HSA-140342",
                "label": "Apoptosis induced DNA fragmentation",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-140342"
              },
              {
                "id": "R-HSA-211736",
                "label": "Stimulation of the cell death response by PAK-2p34",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-211736"
              }
            ],
            "id": "R-HSA-75153",
            "label": "Apoptotic execution phase",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-75153"
          }
        ],
        "id": "R-HSA-109581",
        "label": "Apoptosis",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-109581"
      },
      {
        "groups": [
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-5218900",
                    "label": "CASP8 activity is inhibited",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5218900"
                  }
                ],
                "id": "R-HSA-5675482",
                "label": "Regulation of necroptotic cell death",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5675482"
              }
            ],
            "id": "R-HSA-5213460",
            "label": "RIPK1-mediated regulated necrosis",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5213460"
          }
        ],
        "id": "R-HSA-5218859",
        "label": "Regulated Necrosis",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5218859"
      }
    ],
    "id": "R-HSA-5357801",
    "label": "Programmed Cell Death",
    "weight": 10,
    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5357801"
  },
  {
    "groups": [
      {
        "groups": [
          {
            "id": "R-HSA-9033500",
            "label": "TYSND1 cleaves peroxisomal proteins",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9033500"
          }
        ],
        "id": "R-HSA-9033241",
        "label": "Peroxisomal protein import",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9033241"
      },
      {
        "id": "R-HSA-1268020",
        "label": "Mitochondrial protein import",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1268020"
      }
    ],
    "id": "R-HSA-9609507",
    "label": "Protein localization",
    "weight": 10,
    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9609507"
  },
  {
    "groups": [
      {
        "groups": [
          {
            "id": "R-HSA-1221632",
            "label": "Meiotic synapsis",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1221632"
          },
          {
            "id": "R-HSA-912446",
            "label": "Meiotic recombination",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-912446"
          }
        ],
        "id": "R-HSA-1500620",
        "label": "Meiosis",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1500620"
      },
      {
        "groups": [
          {
            "id": "R-HSA-2534343",
            "label": "Interaction With Cumulus Cells",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2534343"
          },
          {
            "id": "R-HSA-1300645",
            "label": "Acrosome Reaction",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1300645"
          },
          {
            "id": "R-HSA-1300644",
            "label": "Interaction With The Zona Pellucida",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1300644"
          },
          {
            "id": "R-HSA-1300642",
            "label": "Sperm Motility And Taxes",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1300642"
          },
          {
            "id": "R-HSA-1300652",
            "label": "Sperm:Oocyte Membrane Binding",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1300652"
          }
        ],
        "id": "R-HSA-1187000",
        "label": "Fertilization",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1187000"
      }
    ],
    "id": "R-HSA-1474165",
    "label": "Reproduction",
    "weight": 10,
    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1474165"
  },
  {
    "groups": [
      {
        "groups": [
          {
            "id": "R-HSA-75157",
            "label": "FasL/ CD95L signaling",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-75157"
          },
          {
            "id": "R-HSA-75158",
            "label": "TRAIL  signaling",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-75158"
          },
          {
            "groups": [
              {
                "id": "R-HSA-5357905",
                "label": "Regulation of TNFR1 signaling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5357905"
              },
              {
                "id": "R-HSA-5357786",
                "label": "TNFR1-induced proapoptotic signaling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5357786"
              },
              {
                "id": "R-HSA-5357956",
                "label": "TNFR1-induced NFkappaB signaling pathway",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5357956"
              },
              {
                "id": "R-HSA-5626978",
                "label": "TNFR1-mediated ceramide production",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5626978"
              }
            ],
            "id": "R-HSA-75893",
            "label": "TNF signaling",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-75893"
          },
          {
            "groups": [
              {
                "id": "R-HSA-193670",
                "label": "p75NTR negatively regulates cell cycle via SC1",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-193670"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-193634",
                    "label": "Axonal growth inhibition (RHOA activation)",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-193634"
                  },
                  {
                    "id": "R-HSA-209563",
                    "label": "Axonal growth stimulation",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-209563"
                  }
                ],
                "id": "R-HSA-193697",
                "label": "p75NTR regulates axonogenesis",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-193697"
              },
              {
                "id": "R-HSA-193692",
                "label": "Regulated proteolysis of p75NTR",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-193692"
              },
              {
                "id": "R-HSA-193681",
                "label": "Ceramide signalling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-193681"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-209560",
                    "label": "NF-kB is activated and signals survival",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-209560"
                  },
                  {
                    "id": "R-HSA-209543",
                    "label": "p75NTR recruits signalling complexes",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-209543"
                  }
                ],
                "id": "R-HSA-193639",
                "label": "p75NTR signals via NF-kB",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-193639"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-205043",
                    "label": "NRIF signals cell death from the nucleus",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-205043"
                  },
                  {
                    "id": "R-HSA-205025",
                    "label": "NADE modulates death signalling",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-205025"
                  },
                  {
                    "id": "R-HSA-193648",
                    "label": "NRAGE signals death through JNK",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-193648"
                  }
                ],
                "id": "R-HSA-204998",
                "label": "Cell death signalling via NRAGE, NRIF and NADE",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-204998"
              },
              {
                "id": "R-HSA-205017",
                "label": "NFG and proNGF binds to p75NTR",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-205017"
              }
            ],
            "id": "R-HSA-193704",
            "label": "p75 NTR receptor-mediated signalling",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-193704"
          }
        ],
        "id": "R-HSA-73887",
        "label": "Death Receptor Signalling",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-73887"
      },
      {
        "groups": [
          {
            "groups": [
              {
                "id": "R-HSA-1912399",
                "label": "Pre-NOTCH Processing in the Endoplasmic Reticulum",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1912399"
              },
              {
                "id": "R-HSA-1912408",
                "label": "Pre-NOTCH Transcription and Translation",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1912408"
              },
              {
                "id": "R-HSA-1912420",
                "label": "Pre-NOTCH Processing in Golgi",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1912420"
              }
            ],
            "id": "R-HSA-1912422",
            "label": "Pre-NOTCH Expression and Processing",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1912422"
          },
          {
            "groups": [
              {
                "id": "R-HSA-2122948",
                "label": "Activated NOTCH1 Transmits Signal to the Nucleus",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2122948"
              },
              {
                "id": "R-HSA-2122947",
                "label": "NOTCH1 Intracellular Domain Regulates Transcription",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2122947"
              }
            ],
            "id": "R-HSA-1980143",
            "label": "Signaling by NOTCH1",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1980143"
          },
          {
            "groups": [
              {
                "id": "R-HSA-2979096",
                "label": "NOTCH2 Activation and Transmission of Signal to the Nucleus",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2979096"
              },
              {
                "id": "R-HSA-2197563",
                "label": "NOTCH2 intracellular domain regulates transcription",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2197563"
              }
            ],
            "id": "R-HSA-1980145",
            "label": "Signaling by NOTCH2",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1980145"
          },
          {
            "groups": [
              {
                "id": "R-HSA-9013508",
                "label": "NOTCH3 Intracellular Domain Regulates Transcription",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9013508"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-9017802",
                    "label": "Noncanonical activation of NOTCH3",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9017802"
                  }
                ],
                "id": "R-HSA-9013507",
                "label": "NOTCH3 Activation and Transmission of Signal to the Nucleus",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9013507"
              }
            ],
            "id": "R-HSA-9012852",
            "label": "Signaling by NOTCH3",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9012852"
          },
          {
            "groups": [
              {
                "id": "R-HSA-9013695",
                "label": "NOTCH4 Intracellular Domain Regulates Transcription",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9013695"
              },
              {
                "id": "R-HSA-9013700",
                "label": "NOTCH4 Activation and Transmission of Signal to the Nucleus",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9013700"
              },
              {
                "id": "R-HSA-9604323",
                "label": "Negative regulation of NOTCH4 signaling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9604323"
              }
            ],
            "id": "R-HSA-9013694",
            "label": "Signaling by NOTCH4",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9013694"
          }
        ],
        "id": "R-HSA-157118",
        "label": "Signaling by NOTCH",
        "weight": 20,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-157118"
      },
      {
        "groups": [
          {
            "id": "R-HSA-9027276",
            "label": "Erythropoietin activates Phosphoinositide-3-kinase (PI3K)",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9027276"
          },
          {
            "id": "R-HSA-9027277",
            "label": "Erythropoietin activates Phospholipase C gamma (PLCG)",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9027277"
          },
          {
            "id": "R-HSA-9027284",
            "label": "Erythropoietin activates RAS",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9027284"
          },
          {
            "id": "R-HSA-9027283",
            "label": "Erythropoietin activates STAT5",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9027283"
          }
        ],
        "id": "R-HSA-9006335",
        "label": "Signaling by Erythropoietin",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9006335"
      },
      {
        "groups": [
          {
            "groups": [
              {
                "groups": [
                  {
                    "groups": [
                      {
                        "id": "R-HSA-111957",
                        "label": "Cam-PDE 1 activation",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-111957"
                      },
                      {
                        "groups": [
                          {
                            "id": "R-HSA-163615",
                            "label": "PKA activation",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-163615"
                          }
                        ],
                        "id": "R-HSA-111931",
                        "label": "PKA-mediated phosphorylation of CREB",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-111931"
                      },
                      {
                        "id": "R-HSA-111932",
                        "label": "CaMK IV-mediated phosphorylation of CREB",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-111932"
                      }
                    ],
                    "id": "R-HSA-111933",
                    "label": "Calmodulin induced events",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-111933"
                  }
                ],
                "id": "R-HSA-111997",
                "label": "CaM pathway",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-111997"
              }
            ],
            "id": "R-HSA-1489509",
            "label": "DAG and IP3 signaling",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1489509"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "groups": [
                      {
                        "id": "R-HSA-8948700",
                        "label": "Competing endogenous RNAs (ceRNAs) regulate PTEN translation",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8948700"
                      }
                    ],
                    "id": "R-HSA-8943723",
                    "label": "Regulation of PTEN mRNA translation",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8943723"
                  },
                  {
                    "id": "R-HSA-8943724",
                    "label": "Regulation of PTEN gene transcription",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8943724"
                  },
                  {
                    "id": "R-HSA-8948751",
                    "label": "Regulation of PTEN stability and activity",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8948751"
                  },
                  {
                    "id": "R-HSA-8948747",
                    "label": "Regulation of PTEN localization",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8948747"
                  }
                ],
                "id": "R-HSA-6807070",
                "label": "PTEN Regulation",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6807070"
              },
              {
                "id": "R-HSA-198323",
                "label": "AKT phosphorylates targets in the cytosol",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-198323"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-6811558",
                    "label": "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6811558"
                  }
                ],
                "id": "R-HSA-199418",
                "label": "Negative regulation of the PI3K/AKT network",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-199418"
              },
              {
                "id": "R-HSA-198693",
                "label": "AKT phosphorylates targets in the nucleus",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-198693"
              }
            ],
            "id": "R-HSA-1257604",
            "label": "PIP3 activates AKT signaling",
            "weight": 20,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1257604"
          }
        ],
        "id": "R-HSA-9006925",
        "label": "Intracellular signaling by second messengers",
        "weight": 30,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9006925"
      },
      {
        "groups": [
          {
            "groups": [
              {
                "id": "R-HSA-372708",
                "label": "p130Cas linkage to MAPK signaling for integrins",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-372708"
              },
              {
                "id": "R-HSA-354194",
                "label": "GRB2:SOS provides linkage to MAPK signaling for Integrins ",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-354194"
              }
            ],
            "id": "R-HSA-354192",
            "label": "Integrin alphaIIb beta3 signaling",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-354192"
          }
        ],
        "id": "R-HSA-9006921",
        "label": "Integrin signaling",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9006921"
      },
      {
        "groups": [
          {
            "groups": [
              {
                "id": "R-HSA-5365859",
                "label": "RA biosynthesis pathway",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5365859"
              }
            ],
            "id": "R-HSA-5362517",
            "label": "Signaling by Retinoic Acid",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5362517"
          },
          {
            "groups": [
              {
                "id": "R-HSA-9018519",
                "label": "Estrogen-dependent gene expression",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9018519"
              }
            ],
            "id": "R-HSA-8939211",
            "label": "ESR-mediated signaling",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8939211"
          }
        ],
        "id": "R-HSA-9006931",
        "label": "Signaling by Nuclear Receptors",
        "weight": 20,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9006931"
      },
      {
        "groups": [
          {
            "groups": [
              {
                "id": "R-HSA-8847993",
                "label": "ERBB2 Activates PTK6 Signaling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8847993"
              },
              {
                "id": "R-HSA-8849468",
                "label": "PTK6 Regulates Proteins Involved in RNA Processing",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8849468"
              },
              {
                "id": "R-HSA-8849469",
                "label": "PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8849469"
              },
              {
                "id": "R-HSA-8849470",
                "label": "PTK6 Regulates Cell Cycle",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8849470"
              },
              {
                "id": "R-HSA-8849471",
                "label": "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8849471"
              },
              {
                "id": "R-HSA-8849472",
                "label": "PTK6 Down-Regulation",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8849472"
              },
              {
                "id": "R-HSA-8849473",
                "label": "PTK6 Expression",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8849473"
              },
              {
                "id": "R-HSA-8849474",
                "label": "PTK6 Activates STAT3",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8849474"
              },
              {
                "id": "R-HSA-8857538",
                "label": "PTK6 promotes HIF1A stabilization",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8857538"
              }
            ],
            "id": "R-HSA-8848021",
            "label": "Signaling by PTK6",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8848021"
          }
        ],
        "id": "R-HSA-9006927",
        "label": "Signaling by Non-Receptor Tyrosine Kinases",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9006927"
      },
      {
        "groups": [
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-2173788",
                    "label": "Downregulation of TGF-beta receptor signaling",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2173788"
                  }
                ],
                "id": "R-HSA-2173789",
                "label": "TGF-beta receptor signaling activates SMADs",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2173789"
              },
              {
                "id": "R-HSA-2173791",
                "label": "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2173791"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-2173796",
                    "label": "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2173796"
                  },
                  {
                    "id": "R-HSA-2173795",
                    "label": "Downregulation of SMAD2/3:SMAD4 transcriptional activity",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2173795"
                  }
                ],
                "id": "R-HSA-2173793",
                "label": "Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2173793"
              }
            ],
            "id": "R-HSA-170834",
            "label": "Signaling by TGF-beta Receptor Complex",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-170834"
          },
          {
            "groups": [
              {
                "id": "R-HSA-2473224",
                "label": "Antagonism of Activin by Follistatin",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2473224"
              }
            ],
            "id": "R-HSA-1502540",
            "label": "Signaling by Activin",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1502540"
          },
          {
            "id": "R-HSA-201451",
            "label": "Signaling by BMP",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-201451"
          }
        ],
        "id": "R-HSA-9006936",
        "label": "Signaling by TGF-beta family members",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9006936"
      },
      {
        "groups": [
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-9026357",
                    "label": "NTF4 activates NTRK2 (TRKB) signaling",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9026357"
                  },
                  {
                    "id": "R-HSA-9026527",
                    "label": "Activated NTRK2 signals through PLCG1",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9026527"
                  },
                  {
                    "id": "R-HSA-9026519",
                    "label": "Activated NTRK2 signals through RAS",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9026519"
                  },
                  {
                    "id": "R-HSA-9028335",
                    "label": "Activated NTRK2 signals through PI3K",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9028335"
                  },
                  {
                    "id": "R-HSA-9028731",
                    "label": "Activated NTRK2 signals through FRS2 and FRS3",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9028731"
                  },
                  {
                    "id": "R-HSA-9024909",
                    "label": "BDNF activates NTRK2 (TRKB) signaling",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9024909"
                  },
                  {
                    "id": "R-HSA-9025046",
                    "label": "NTF3 activates NTRK2 (TRKB) signaling",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9025046"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-9032759",
                        "label": "NTRK2 activates RAC1",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9032759"
                      }
                    ],
                    "id": "R-HSA-9032500",
                    "label": "Activated NTRK2 signals through FYN",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9032500"
                  },
                  {
                    "id": "R-HSA-9032845",
                    "label": "Activated NTRK2 signals through CDK5",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9032845"
                  }
                ],
                "id": "R-HSA-9006115",
                "label": "Signaling by NTRK2 (TRKB)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9006115"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-9034013",
                    "label": "NTF3 activates NTRK3 signaling",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9034013"
                  },
                  {
                    "id": "R-HSA-9034864",
                    "label": "Activated NTRK3 signals through RAS",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9034864"
                  },
                  {
                    "id": "R-HSA-9034793",
                    "label": "Activated NTRK3 signals through PLCG1",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9034793"
                  },
                  {
                    "id": "R-HSA-9603381",
                    "label": "Activated NTRK3 signals through PI3K",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9603381"
                  },
                  {
                    "id": "R-HSA-9603505",
                    "label": "NTRK3 as a dependence receptor",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9603505"
                  }
                ],
                "id": "R-HSA-9034015",
                "label": "Signaling by NTRK3 (TRKC)",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9034015"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-167021",
                    "label": "PLC-gamma1 signalling",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-167021"
                  },
                  {
                    "id": "R-HSA-177504",
                    "label": "Retrograde neurotrophin signalling",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-177504"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-187042",
                        "label": "TRKA activation by NGF",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-187042"
                      },
                      {
                        "id": "R-HSA-187024",
                        "label": "NGF-independant TRKA activation",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-187024"
                      }
                    ],
                    "id": "R-HSA-187015",
                    "label": "Activation of TRKA receptors",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-187015"
                  },
                  {
                    "groups": [
                      {
                        "groups": [
                          {
                            "id": "R-HSA-171007",
                            "label": "p38MAPK events",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-171007"
                          }
                        ],
                        "id": "R-HSA-167044",
                        "label": "Signalling to RAS",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-167044"
                      },
                      {
                        "groups": [
                          {
                            "id": "R-HSA-170968",
                            "label": "Frs2-mediated activation",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-170968"
                          },
                          {
                            "id": "R-HSA-170984",
                            "label": "ARMS-mediated activation",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-170984"
                          }
                        ],
                        "id": "R-HSA-169893",
                        "label": "Prolonged ERK activation events",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-169893"
                      },
                      {
                        "id": "R-HSA-187706",
                        "label": "Signalling to p38 via RIT and RIN",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-187706"
                      }
                    ],
                    "id": "R-HSA-187687",
                    "label": "Signalling to ERKs",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-187687"
                  },
                  {
                    "id": "R-HSA-198203",
                    "label": "PI3K/AKT activation",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-198203"
                  },
                  {
                    "id": "R-HSA-198745",
                    "label": "Signalling to STAT3",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-198745"
                  },
                  {
                    "groups": [
                      {
                        "groups": [
                          {
                            "id": "R-HSA-202670",
                            "label": "ERKs are inactivated",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-202670"
                          }
                        ],
                        "id": "R-HSA-198753",
                        "label": "ERK/MAPK targets",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-198753"
                      },
                      {
                        "id": "R-HSA-199920",
                        "label": "CREB phosphorylation",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-199920"
                      }
                    ],
                    "id": "R-HSA-198725",
                    "label": "Nuclear Events (kinase and transcription factor activation)",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-198725"
                  },
                  {
                    "id": "R-HSA-198765",
                    "label": "Signalling to ERK5",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-198765"
                  }
                ],
                "id": "R-HSA-187037",
                "label": "Signaling by NTRK1 (TRKA)",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-187037"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-167060",
                    "label": "NGF processing",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-167060"
                  }
                ],
                "id": "R-HSA-9036866",
                "label": "Expression and Processing of Neurotrophins",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9036866"
              }
            ],
            "id": "R-HSA-166520",
            "label": "Signaling by NTRKs",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-166520"
          },
          {
            "groups": [
              {
                "id": "R-HSA-212718",
                "label": "EGFR interacts with phospholipase C-gamma",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-212718"
              },
              {
                "id": "R-HSA-179812",
                "label": "GRB2 events in EGFR signaling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-179812"
              },
              {
                "id": "R-HSA-180292",
                "label": "GAB1 signalosome",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-180292"
              },
              {
                "id": "R-HSA-180336",
                "label": "SHC1 events in EGFR signaling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-180336"
              },
              {
                "id": "R-HSA-182971",
                "label": "EGFR downregulation",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-182971"
              }
            ],
            "id": "R-HSA-177929",
            "label": "Signaling by EGFR",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-177929"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-1358803",
                    "label": "Downregulation of ERBB2:ERBB3 signaling",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1358803"
                  }
                ],
                "id": "R-HSA-8863795",
                "label": "Downregulation of ERBB2 signaling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8863795"
              },
              {
                "id": "R-HSA-6785631",
                "label": "ERBB2 Regulates Cell Motility",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6785631"
              },
              {
                "id": "R-HSA-1306955",
                "label": "GRB7 events in ERBB2 signaling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1306955"
              },
              {
                "id": "R-HSA-1963640",
                "label": "GRB2 events in ERBB2 signaling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1963640"
              },
              {
                "id": "R-HSA-1963642",
                "label": "PI3K events in ERBB2 signaling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1963642"
              },
              {
                "id": "R-HSA-8847993",
                "label": "ERBB2 Activates PTK6 Signaling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8847993"
              },
              {
                "id": "R-HSA-1250196",
                "label": "SHC1 events in ERBB2 signaling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1250196"
              },
              {
                "id": "R-HSA-1251932",
                "label": "PLCG1 events in ERBB2 signaling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1251932"
              }
            ],
            "id": "R-HSA-1227986",
            "label": "Signaling by ERBB2",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1227986"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "groups": [
                      {
                        "groups": [
                          {
                            "groups": [
                              {
                                "id": "R-HSA-165158",
                                "label": "Activation of AKT2",
                                "weight": 9,
                                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-165158"
                              },
                              {
                                "groups": [
                                  {
                                    "id": "R-HSA-165160",
                                    "label": "PDE3B signalling",
                                    "weight": 9,
                                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-165160"
                                  }
                                ],
                                "id": "R-HSA-109703",
                                "label": "PKB-mediated events",
                                "weight": 9,
                                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-109703"
                              }
                            ],
                            "id": "R-HSA-109704",
                            "label": "PI3K Cascade",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-109704"
                          },
                          {
                            "id": "R-HSA-112412",
                            "label": "SOS-mediated signalling",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-112412"
                          }
                        ],
                        "id": "R-HSA-112399",
                        "label": "IRS-mediated signalling",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-112399"
                      }
                    ],
                    "id": "R-HSA-2428928",
                    "label": "IRS-related events triggered by IGF1R",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2428928"
                  },
                  {
                    "id": "R-HSA-2428933",
                    "label": "SHC-related events triggered by IGF1R",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2428933"
                  }
                ],
                "id": "R-HSA-2428924",
                "label": "IGF1R signaling cascade",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2428924"
              }
            ],
            "id": "R-HSA-2404192",
            "label": "Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2404192"
          },
          {
            "groups": [
              {
                "id": "R-HSA-186763",
                "label": "Downstream signal transduction",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-186763"
              }
            ],
            "id": "R-HSA-186797",
            "label": "Signaling by PDGF",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-186797"
          },
          {
            "groups": [
              {
                "id": "R-HSA-8865999",
                "label": "MET activates PTPN11",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8865999"
              },
              {
                "id": "R-HSA-8875791",
                "label": "MET activates STAT3",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8875791"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-8874081",
                    "label": "MET activates PTK2 signaling",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8874081"
                  },
                  {
                    "id": "R-HSA-8875555",
                    "label": "MET activates RAP1 and RAC1",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8875555"
                  },
                  {
                    "id": "R-HSA-8875513",
                    "label": "MET interacts with TNS proteins",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8875513"
                  }
                ],
                "id": "R-HSA-8875878",
                "label": "MET promotes cell motility",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8875878"
              },
              {
                "id": "R-HSA-8875656",
                "label": "MET receptor recycling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8875656"
              },
              {
                "id": "R-HSA-6807004",
                "label": "Negative regulation of MET activity",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6807004"
              },
              {
                "id": "R-HSA-6806942",
                "label": "MET Receptor Activation",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6806942"
              },
              {
                "id": "R-HSA-8851805",
                "label": "MET activates RAS signaling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8851805"
              },
              {
                "id": "R-HSA-8851907",
                "label": "MET activates PI3K/AKT signaling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8851907"
              }
            ],
            "id": "R-HSA-6806834",
            "label": "Signaling by MET",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6806834"
          },
          {
            "groups": [
              {
                "id": "R-HSA-1250347",
                "label": "SHC1 events in ERBB4 signaling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1250347"
              },
              {
                "id": "R-HSA-1250342",
                "label": "PI3K events in ERBB4 signaling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1250342"
              },
              {
                "id": "R-HSA-1251985",
                "label": "Nuclear signaling by ERBB4",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1251985"
              },
              {
                "id": "R-HSA-1253288",
                "label": "Downregulation of ERBB4 signaling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1253288"
              }
            ],
            "id": "R-HSA-1236394",
            "label": "Signaling by ERBB4",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1236394"
          },
          {
            "groups": [
              {
                "id": "R-HSA-1433559",
                "label": "Regulation of KIT signaling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1433559"
              }
            ],
            "id": "R-HSA-1433557",
            "label": "Signaling by SCF-KIT",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1433557"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-5218921",
                    "label": "VEGFR2 mediated cell proliferation",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5218921"
                  },
                  {
                    "id": "R-HSA-5218920",
                    "label": "VEGFR2 mediated vascular permeability",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5218920"
                  }
                ],
                "id": "R-HSA-4420097",
                "label": "VEGFA-VEGFR2 Pathway",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4420097"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-195399",
                    "label": "VEGF binds to VEGFR leading to receptor dimerization",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-195399"
                  }
                ],
                "id": "R-HSA-194313",
                "label": "VEGF ligand-receptor interactions",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-194313"
              },
              {
                "id": "R-HSA-194306",
                "label": "Neurophilin interactions with VEGF and VEGFR",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-194306"
              }
            ],
            "id": "R-HSA-194138",
            "label": "Signaling by VEGF",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-194138"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "groups": [
                      {
                        "id": "R-HSA-5654219",
                        "label": "Phospholipase C-mediated cascade: FGFR1",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5654219"
                      },
                      {
                        "id": "R-HSA-5654688",
                        "label": "SHC-mediated cascade:FGFR1",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5654688"
                      },
                      {
                        "id": "R-HSA-5654689",
                        "label": "PI-3K cascade:FGFR1",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5654689"
                      },
                      {
                        "id": "R-HSA-5654693",
                        "label": "FRS-mediated FGFR1 signaling",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5654693"
                      }
                    ],
                    "id": "R-HSA-5654687",
                    "label": "Downstream signaling of activated FGFR1",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5654687"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-1295596",
                        "label": "Spry regulation of FGF signaling",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1295596"
                      }
                    ],
                    "id": "R-HSA-5654726",
                    "label": "Negative regulation of FGFR1 signaling",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5654726"
                  },
                  {
                    "id": "R-HSA-5658623",
                    "label": "FGFRL1 modulation of FGFR1 signaling",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5658623"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-190374",
                        "label": "FGFR1c and Klotho ligand binding and activation",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-190374"
                      },
                      {
                        "id": "R-HSA-190370",
                        "label": "FGFR1b ligand binding and activation",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-190370"
                      },
                      {
                        "id": "R-HSA-190373",
                        "label": "FGFR1c ligand binding and activation",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-190373"
                      }
                    ],
                    "id": "R-HSA-190242",
                    "label": "FGFR1 ligand binding and activation",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-190242"
                  }
                ],
                "id": "R-HSA-5654736",
                "label": "Signaling by FGFR1",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5654736"
              },
              {
                "groups": [
                  {
                    "groups": [
                      {
                        "id": "R-HSA-5654221",
                        "label": "Phospholipase C-mediated cascade; FGFR2",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5654221"
                      },
                      {
                        "id": "R-HSA-5654695",
                        "label": "PI-3K cascade:FGFR2",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5654695"
                      },
                      {
                        "id": "R-HSA-5654699",
                        "label": "SHC-mediated cascade:FGFR2",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5654699"
                      },
                      {
                        "id": "R-HSA-5654700",
                        "label": "FRS-mediated FGFR2 signaling",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5654700"
                      }
                    ],
                    "id": "R-HSA-5654696",
                    "label": "Downstream signaling of activated FGFR2",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5654696"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-1295596",
                        "label": "Spry regulation of FGF signaling",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1295596"
                      }
                    ],
                    "id": "R-HSA-5654727",
                    "label": "Negative regulation of FGFR2 signaling",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5654727"
                  },
                  {
                    "id": "R-HSA-6803529",
                    "label": "FGFR2 alternative splicing",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6803529"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-190377",
                        "label": "FGFR2b ligand binding and activation",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-190377"
                      },
                      {
                        "id": "R-HSA-190375",
                        "label": "FGFR2c ligand binding and activation",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-190375"
                      }
                    ],
                    "id": "R-HSA-190241",
                    "label": "FGFR2 ligand binding and activation",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-190241"
                  }
                ],
                "id": "R-HSA-5654738",
                "label": "Signaling by FGFR2",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5654738"
              },
              {
                "groups": [
                  {
                    "groups": [
                      {
                        "id": "R-HSA-1295596",
                        "label": "Spry regulation of FGF signaling",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1295596"
                      }
                    ],
                    "id": "R-HSA-5654732",
                    "label": "Negative regulation of FGFR3 signaling",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5654732"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-5654710",
                        "label": "PI-3K cascade:FGFR3",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5654710"
                      },
                      {
                        "id": "R-HSA-5654704",
                        "label": "SHC-mediated cascade:FGFR3",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5654704"
                      },
                      {
                        "id": "R-HSA-5654706",
                        "label": "FRS-mediated FGFR3 signaling",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5654706"
                      },
                      {
                        "id": "R-HSA-5654227",
                        "label": "Phospholipase C-mediated cascade; FGFR3",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5654227"
                      }
                    ],
                    "id": "R-HSA-5654708",
                    "label": "Downstream signaling of activated FGFR3",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5654708"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-190371",
                        "label": "FGFR3b ligand binding and activation",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-190371"
                      },
                      {
                        "id": "R-HSA-190372",
                        "label": "FGFR3c ligand binding and activation",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-190372"
                      }
                    ],
                    "id": "R-HSA-190239",
                    "label": "FGFR3 ligand binding and activation",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-190239"
                  }
                ],
                "id": "R-HSA-5654741",
                "label": "Signaling by FGFR3",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5654741"
              },
              {
                "groups": [
                  {
                    "groups": [
                      {
                        "id": "R-HSA-5654719",
                        "label": "SHC-mediated cascade:FGFR4",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5654719"
                      },
                      {
                        "id": "R-HSA-5654720",
                        "label": "PI-3K cascade:FGFR4",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5654720"
                      },
                      {
                        "id": "R-HSA-5654712",
                        "label": "FRS-mediated FGFR4 signaling",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5654712"
                      },
                      {
                        "id": "R-HSA-5654228",
                        "label": "Phospholipase C-mediated cascade; FGFR4",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5654228"
                      }
                    ],
                    "id": "R-HSA-5654716",
                    "label": "Downstream signaling of activated FGFR4",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5654716"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-1295596",
                        "label": "Spry regulation of FGF signaling",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1295596"
                      }
                    ],
                    "id": "R-HSA-5654733",
                    "label": "Negative regulation of FGFR4 signaling",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5654733"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-1307965",
                        "label": "betaKlotho-mediated ligand binding",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1307965"
                      }
                    ],
                    "id": "R-HSA-190322",
                    "label": "FGFR4 ligand binding and activation",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-190322"
                  }
                ],
                "id": "R-HSA-5654743",
                "label": "Signaling by FGFR4",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5654743"
              }
            ],
            "id": "R-HSA-190236",
            "label": "Signaling by FGFR",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-190236"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "groups": [
                      {
                        "groups": [
                          {
                            "id": "R-HSA-165158",
                            "label": "Activation of AKT2",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-165158"
                          },
                          {
                            "groups": [
                              {
                                "id": "R-HSA-165160",
                                "label": "PDE3B signalling",
                                "weight": 9,
                                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-165160"
                              }
                            ],
                            "id": "R-HSA-109703",
                            "label": "PKB-mediated events",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-109703"
                          }
                        ],
                        "id": "R-HSA-109704",
                        "label": "PI3K Cascade",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-109704"
                      },
                      {
                        "id": "R-HSA-112412",
                        "label": "SOS-mediated signalling",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-112412"
                      }
                    ],
                    "id": "R-HSA-112399",
                    "label": "IRS-mediated signalling",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-112399"
                  },
                  {
                    "id": "R-HSA-74713",
                    "label": "IRS activation",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-74713"
                  },
                  {
                    "id": "R-HSA-74749",
                    "label": "Signal attenuation",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-74749"
                  }
                ],
                "id": "R-HSA-74751",
                "label": "Insulin receptor signalling cascade",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-74751"
              },
              {
                "id": "R-HSA-77387",
                "label": "Insulin receptor recycling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-77387"
              }
            ],
            "id": "R-HSA-74752",
            "label": "Signaling by Insulin receptor",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-74752"
          },
          {
            "id": "R-HSA-8852405",
            "label": "Signaling by MST1",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8852405"
          }
        ],
        "id": "R-HSA-9006934",
        "label": "Signaling by Receptor Tyrosine Kinases",
        "weight": 40,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9006934"
      },
      {
        "id": "R-HSA-2586552",
        "label": "Signaling by Leptin",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2586552"
      },
      {
        "groups": [
          {
            "id": "R-HSA-165181",
            "label": "Inhibition of TSC complex formation by PKB",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-165181"
          },
          {
            "id": "R-HSA-166208",
            "label": "mTORC1-mediated signalling",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-166208"
          },
          {
            "id": "R-HSA-380972",
            "label": "Energy dependent regulation of mTOR by LKB1-AMPK",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-380972"
          }
        ],
        "id": "R-HSA-165159",
        "label": "mTOR signalling",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-165159"
      },
      {
        "groups": [
          {
            "groups": [
              {
                "id": "R-HSA-416482",
                "label": "G alpha (12/13) signalling events",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-416482"
              },
              {
                "groups": [
                  {
                    "groups": [
                      {
                        "id": "R-HSA-2179392",
                        "label": "EGFR Transactivation by Gastrin",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2179392"
                      }
                    ],
                    "id": "R-HSA-881907",
                    "label": "Gastrin-CREB signalling pathway via PKC and MAPK",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-881907"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-426048",
                        "label": "Arachidonate production from DAG",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-426048"
                      }
                    ],
                    "id": "R-HSA-114508",
                    "label": "Effects of PIP2 hydrolysis",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-114508"
                  }
                ],
                "id": "R-HSA-416476",
                "label": "G alpha (q) signalling events",
                "weight": 20,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-416476"
              },
              {
                "id": "R-HSA-418597",
                "label": "G alpha (z) signalling events",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-418597"
              },
              {
                "groups": [
                  {
                    "groups": [
                      {
                        "groups": [
                          {
                            "id": "R-HSA-2485179",
                            "label": "Activation of the phototransduction cascade",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2485179"
                          },
                          {
                            "id": "R-HSA-2514859",
                            "label": "Inactivation, recovery and regulation of the phototransduction cascade",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2514859"
                          }
                        ],
                        "id": "R-HSA-2514856",
                        "label": "The phototransduction cascade",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2514856"
                      },
                      {
                        "id": "R-HSA-2187335",
                        "label": "The retinoid cycle in cones (daylight vision)",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2187335"
                      },
                      {
                        "groups": [
                          {
                            "id": "R-HSA-2466712",
                            "label": "Biosynthesis of A2E, implicated in retinal degradation",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2466712"
                          }
                        ],
                        "id": "R-HSA-2453902",
                        "label": "The canonical retinoid cycle in rods (twilight vision)",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2453902"
                      },
                      {
                        "id": "R-HSA-975634",
                        "label": "Retinoid metabolism and transport",
                        "weight": 10,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-975634"
                      }
                    ],
                    "id": "R-HSA-2187338",
                    "label": "Visual phototransduction",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2187338"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-202040",
                        "label": "G-protein activation",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-202040"
                      },
                      {
                        "groups": [
                          {
                            "id": "R-HSA-170660",
                            "label": "Adenylate cyclase activating pathway",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-170660"
                          },
                          {
                            "id": "R-HSA-170670",
                            "label": "Adenylate cyclase inhibitory pathway",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-170670"
                          },
                          {
                            "groups": [
                              {
                                "groups": [
                                  {
                                    "id": "R-HSA-111995",
                                    "label": "phospho-PLA2 pathway",
                                    "weight": 9,
                                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-111995"
                                  },
                                  {
                                    "groups": [
                                      {
                                        "groups": [
                                          {
                                            "id": "R-HSA-111957",
                                            "label": "Cam-PDE 1 activation",
                                            "weight": 9,
                                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-111957"
                                          },
                                          {
                                            "groups": [
                                              {
                                                "id": "R-HSA-163615",
                                                "label": "PKA activation",
                                                "weight": 9,
                                                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-163615"
                                              }
                                            ],
                                            "id": "R-HSA-111931",
                                            "label": "PKA-mediated phosphorylation of CREB",
                                            "weight": 9,
                                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-111931"
                                          },
                                          {
                                            "id": "R-HSA-111932",
                                            "label": "CaMK IV-mediated phosphorylation of CREB",
                                            "weight": 9,
                                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-111932"
                                          }
                                        ],
                                        "id": "R-HSA-111933",
                                        "label": "Calmodulin induced events",
                                        "weight": 9,
                                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-111933"
                                      }
                                    ],
                                    "id": "R-HSA-111997",
                                    "label": "CaM pathway",
                                    "weight": 9,
                                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-111997"
                                  }
                                ],
                                "id": "R-HSA-111996",
                                "label": "Ca-dependent events",
                                "weight": 9,
                                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-111996"
                              }
                            ],
                            "id": "R-HSA-112043",
                            "label": "PLC beta mediated events",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-112043"
                          }
                        ],
                        "id": "R-HSA-112040",
                        "label": "G-protein mediated events",
                        "weight": 10,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-112040"
                      },
                      {
                        "id": "R-HSA-180024",
                        "label": "DARPP-32 events",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-180024"
                      }
                    ],
                    "id": "R-HSA-111885",
                    "label": "Opioid Signalling",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-111885"
                  }
                ],
                "id": "R-HSA-418594",
                "label": "G alpha (i) signalling events",
                "weight": 40,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-418594"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-381753",
                    "label": "Olfactory Signaling Pathway",
                    "weight": 30,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-381753"
                  }
                ],
                "id": "R-HSA-418555",
                "label": "G alpha (s) signalling events",
                "weight": 40,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-418555"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-392451",
                    "label": "G beta:gamma signalling through PI3Kgamma",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-392451"
                  },
                  {
                    "id": "R-HSA-418217",
                    "label": "G beta:gamma signalling through PLC beta",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-418217"
                  },
                  {
                    "id": "R-HSA-8964315",
                    "label": "G beta:gamma signalling through BTK",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8964315"
                  },
                  {
                    "id": "R-HSA-8964616",
                    "label": "G beta:gamma signalling through CDC42",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8964616"
                  }
                ],
                "id": "R-HSA-397795",
                "label": "G-protein beta:gamma signalling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-397795"
              }
            ],
            "id": "R-HSA-388396",
            "label": "GPCR downstream signalling",
            "weight": 100,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-388396"
          },
          {
            "groups": [
              {
                "id": "R-HSA-420499",
                "label": "Class C/3 (Metabotropic glutamate/pheromone receptors)",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-420499"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-419812",
                    "label": "Calcitonin-like ligand receptors",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-419812"
                  },
                  {
                    "id": "R-HSA-420092",
                    "label": "Glucagon-type ligand receptors",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-420092"
                  }
                ],
                "id": "R-HSA-373080",
                "label": "Class B/2 (Secretin family receptors)",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-373080"
              },
              {
                "groups": [
                  {
                    "groups": [
                      {
                        "id": "R-HSA-390696",
                        "label": "Adrenoceptors",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-390696"
                      },
                      {
                        "id": "R-HSA-390666",
                        "label": "Serotonin receptors",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-390666"
                      },
                      {
                        "id": "R-HSA-390651",
                        "label": "Dopamine receptors",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-390651"
                      },
                      {
                        "id": "R-HSA-390650",
                        "label": "Histamine receptors",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-390650"
                      },
                      {
                        "id": "R-HSA-390648",
                        "label": "Muscarinic acetylcholine receptors",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-390648"
                      }
                    ],
                    "id": "R-HSA-375280",
                    "label": "Amine ligand-binding receptors",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-375280"
                  },
                  {
                    "id": "R-HSA-375281",
                    "label": "Hormone ligand-binding receptors",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-375281"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-444473",
                        "label": "Formyl peptide receptors bind formyl peptides and many other ligands",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-444473"
                      },
                      {
                        "id": "R-HSA-444821",
                        "label": "Relaxin receptors",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-444821"
                      },
                      {
                        "id": "R-HSA-380108",
                        "label": "Chemokine receptors bind chemokines",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-380108"
                      },
                      {
                        "id": "R-HSA-380095",
                        "label": "Tachykinin receptors bind tachykinins",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-380095"
                      },
                      {
                        "id": "R-HSA-388479",
                        "label": "Vasopressin-like receptors",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-388479"
                      },
                      {
                        "id": "R-HSA-389397",
                        "label": "Orexin and neuropeptides FF and QRFP bind to their respective receptors",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-389397"
                      }
                    ],
                    "id": "R-HSA-375276",
                    "label": "Peptide ligand-binding receptors",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-375276"
                  },
                  {
                    "id": "R-HSA-444209",
                    "label": "Free fatty acid receptors",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-444209"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-391908",
                        "label": "Prostanoid ligand receptors",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-391908"
                      },
                      {
                        "id": "R-HSA-391906",
                        "label": "Leukotriene receptors",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-391906"
                      }
                    ],
                    "id": "R-HSA-391903",
                    "label": "Eicosanoid ligand-binding receptors",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-391903"
                  },
                  {
                    "id": "R-HSA-3296197",
                    "label": "Hydroxycarboxylic acid-binding receptors",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3296197"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-417957",
                        "label": "P2Y receptors",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-417957"
                      },
                      {
                        "id": "R-HSA-417973",
                        "label": "Adenosine P1 receptors",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-417973"
                      }
                    ],
                    "id": "R-HSA-418038",
                    "label": "Nucleotide-like (purinergic) receptors",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-418038"
                  },
                  {
                    "id": "R-HSA-419408",
                    "label": "Lysosphingolipid and LPA receptors",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-419408"
                  },
                  {
                    "id": "R-HSA-419771",
                    "label": "Opsins",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-419771"
                  }
                ],
                "id": "R-HSA-373076",
                "label": "Class A/1 (Rhodopsin-like receptors)",
                "weight": 30,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-373076"
              }
            ],
            "id": "R-HSA-500792",
            "label": "GPCR ligand binding",
            "weight": 50,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-500792"
          }
        ],
        "id": "R-HSA-372790",
        "label": "Signaling by GPCR",
        "weight": 110,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-372790"
      },
      {
        "groups": [
          {
            "id": "R-HSA-5687128",
            "label": "MAPK6/MAPK4 signaling",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5687128"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-5674135",
                    "label": "MAP2K and MAPK activation",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5674135"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-5674499",
                        "label": "Negative feedback regulation of MAPK pathway",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5674499"
                      }
                    ],
                    "id": "R-HSA-5675221",
                    "label": "Negative regulation of MAPK pathway",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5675221"
                  },
                  {
                    "id": "R-HSA-5673000",
                    "label": "RAF activation",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5673000"
                  },
                  {
                    "id": "R-HSA-5658442",
                    "label": "Regulation of RAS by GAPs",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5658442"
                  }
                ],
                "id": "R-HSA-5673001",
                "label": "RAF/MAP kinase cascade",
                "weight": 20,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5673001"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-110056",
                    "label": "MAPK3 (ERK1) activation",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-110056"
                  },
                  {
                    "id": "R-HSA-112411",
                    "label": "MAPK1 (ERK2) activation",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-112411"
                  }
                ],
                "id": "R-HSA-112409",
                "label": "RAF-independent MAPK1/3 activation",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-112409"
              }
            ],
            "id": "R-HSA-5684996",
            "label": "MAPK1/MAPK3 signaling",
            "weight": 20,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5684996"
          }
        ],
        "id": "R-HSA-5683057",
        "label": "MAPK family signaling cascades",
        "weight": 20,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5683057"
      },
      {
        "groups": [
          {
            "groups": [
              {
                "id": "R-HSA-5610780",
                "label": "Degradation of GLI1 by the proteasome",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5610780"
              },
              {
                "id": "R-HSA-5610785",
                "label": "GLI3 is processed to GLI3R by the proteasome",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5610785"
              },
              {
                "id": "R-HSA-5610783",
                "label": "Degradation of GLI2 by the proteasome",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5610783"
              }
            ],
            "id": "R-HSA-5610787",
            "label": "Hedgehog 'off' state",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5610787"
          },
          {
            "groups": [
              {
                "id": "R-HSA-5362798",
                "label": "Release of Hh-Np from the secreting cell",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5362798"
              }
            ],
            "id": "R-HSA-5358346",
            "label": "Hedgehog ligand biogenesis",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5358346"
          },
          {
            "groups": [
              {
                "id": "R-HSA-5632681",
                "label": "Ligand-receptor interactions",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5632681"
              },
              {
                "id": "R-HSA-5635851",
                "label": "GLI proteins bind promoters of Hh responsive genes to promote transcription",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5635851"
              },
              {
                "id": "R-HSA-5635838",
                "label": "Activation of SMO",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5635838"
              }
            ],
            "id": "R-HSA-5632684",
            "label": "Hedgehog 'on' state",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5632684"
          }
        ],
        "id": "R-HSA-5358351",
        "label": "Signaling by Hedgehog",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5358351"
      },
      {
        "id": "R-HSA-2028269",
        "label": "Signaling by Hippo",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2028269"
      },
      {
        "groups": [
          {
            "id": "R-HSA-194840",
            "label": "Rho GTPase cycle",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-194840"
          },
          {
            "groups": [
              {
                "id": "R-HSA-5625900",
                "label": "RHO GTPases activate CIT",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5625900"
              },
              {
                "id": "R-HSA-5625970",
                "label": "RHO GTPases activate KTN1",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5625970"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-5625886",
                    "label": "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5625886"
                  }
                ],
                "id": "R-HSA-5625740",
                "label": "RHO GTPases activate PKNs",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5625740"
              },
              {
                "id": "R-HSA-5626467",
                "label": "RHO GTPases activate IQGAPs",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5626467"
              },
              {
                "id": "R-HSA-5627117",
                "label": "RHO GTPases Activate ROCKs",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5627117"
              },
              {
                "id": "R-HSA-5627123",
                "label": "RHO GTPases activate PAKs",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5627123"
              },
              {
                "id": "R-HSA-5627083",
                "label": "RHO GTPases regulate CFTR trafficking",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5627083"
              },
              {
                "id": "R-HSA-5663213",
                "label": "RHO GTPases Activate WASPs and WAVEs",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5663213"
              },
              {
                "id": "R-HSA-5663220",
                "label": "RHO GTPases Activate Formins",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5663220"
              },
              {
                "id": "R-HSA-5666185",
                "label": "RHO GTPases Activate Rhotekin and Rhophilins",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5666185"
              },
              {
                "id": "R-HSA-5668599",
                "label": "RHO GTPases Activate NADPH Oxidases",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5668599"
              }
            ],
            "id": "R-HSA-195258",
            "label": "RHO GTPase Effectors",
            "weight": 20,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-195258"
          }
        ],
        "id": "R-HSA-194315",
        "label": "Signaling by Rho GTPases",
        "weight": 30,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-194315"
      },
      {
        "groups": [
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-4608870",
                    "label": "Asymmetric localization of PCP proteins",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4608870"
                  },
                  {
                    "id": "R-HSA-5140745",
                    "label": "WNT5A-dependent internalization of FZD2, FZD5 and ROR2",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5140745"
                  },
                  {
                    "id": "R-HSA-5099900",
                    "label": "WNT5A-dependent internalization of FZD4",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5099900"
                  }
                ],
                "id": "R-HSA-4086400",
                "label": "PCP/CE pathway",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4086400"
              },
              {
                "id": "R-HSA-4086398",
                "label": "Ca2+ pathway",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4086398"
              }
            ],
            "id": "R-HSA-3858494",
            "label": "Beta-catenin independent WNT signaling",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3858494"
          },
          {
            "groups": [
              {
                "id": "R-HSA-4641265",
                "label": "Repression of WNT target genes",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4641265"
              },
              {
                "id": "R-HSA-196299",
                "label": "Beta-catenin phosphorylation cascade",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-196299"
              }
            ],
            "id": "R-HSA-195253",
            "label": "Degradation of beta-catenin by the destruction complex",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-195253"
          },
          {
            "groups": [
              {
                "id": "R-HSA-4641263",
                "label": "Regulation of FZD by ubiquitination",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4641263"
              },
              {
                "id": "R-HSA-4641262",
                "label": "Disassembly of the destruction complex and recruitment of AXIN to the membrane",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4641262"
              },
              {
                "id": "R-HSA-4641257",
                "label": "Degradation of AXIN",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4641257"
              },
              {
                "id": "R-HSA-4641258",
                "label": "Degradation of DVL",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4641258"
              },
              {
                "id": "R-HSA-5368598",
                "label": "Negative regulation of TCF-dependent signaling by DVL-interacting proteins",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5368598"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-4411364",
                    "label": "Binding of TCF/LEF:CTNNB1 to target gene promoters",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-4411364"
                  }
                ],
                "id": "R-HSA-201722",
                "label": "Formation of the beta-catenin:TCF transactivating complex",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-201722"
              },
              {
                "id": "R-HSA-201688",
                "label": "WNT mediated activation of DVL",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-201688"
              },
              {
                "id": "R-HSA-3769402",
                "label": "Deactivation of the beta-catenin transactivating complex",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3769402"
              },
              {
                "id": "R-HSA-3772470",
                "label": "Negative regulation of TCF-dependent signaling by WNT ligand antagonists",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3772470"
              }
            ],
            "id": "R-HSA-201681",
            "label": "TCF dependent signaling in response to WNT",
            "weight": 20,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-201681"
          },
          {
            "id": "R-HSA-3238698",
            "label": "WNT ligand biogenesis and trafficking",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3238698"
          }
        ],
        "id": "R-HSA-195721",
        "label": "Signaling by WNT",
        "weight": 20,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-195721"
      }
    ],
    "id": "R-HSA-162582",
    "label": "Signal Transduction",
    "weight": 230,
    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-162582"
  },
  {
    "groups": [
      {
        "id": "R-HSA-8981607",
        "label": "Intracellular oxygen transport",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8981607"
      },
      {
        "groups": [
          {
            "id": "R-HSA-189200",
            "label": "Cellular hexose transport",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-189200"
          },
          {
            "groups": [
              {
                "id": "R-HSA-727802",
                "label": "Transport of nucleotide sugars",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-727802"
              },
              {
                "id": "R-HSA-83936",
                "label": "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-83936"
              },
              {
                "id": "R-HSA-804914",
                "label": "Transport of fatty acids",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-804914"
              },
              {
                "id": "R-HSA-879518",
                "label": "Transport of organic anions",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-879518"
              }
            ],
            "id": "R-HSA-425397",
            "label": "Transport of vitamins, nucleosides, and related molecules",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-425397"
          },
          {
            "groups": [
              {
                "id": "R-HSA-352230",
                "label": "Amino acid transport across the plasma membrane",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-352230"
              },
              {
                "id": "R-HSA-425561",
                "label": "Sodium/Calcium exchangers",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-425561"
              },
              {
                "id": "R-HSA-425381",
                "label": "Bicarbonate transporters",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-425381"
              },
              {
                "id": "R-HSA-426117",
                "label": "Cation-coupled Chloride cotransporters",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-426117"
              },
              {
                "id": "R-HSA-425986",
                "label": "Sodium/Proton exchangers",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-425986"
              },
              {
                "id": "R-HSA-427601",
                "label": "Multifunctional anion exchangers",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-427601"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-427589",
                    "label": "Type II Na+/Pi cotransporters",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-427589"
                  }
                ],
                "id": "R-HSA-427652",
                "label": "Sodium-coupled phosphate cotransporters",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-427652"
              },
              {
                "id": "R-HSA-427975",
                "label": "Proton/oligopeptide cotransporters",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-427975"
              },
              {
                "id": "R-HSA-428643",
                "label": "Organic anion transporters",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-428643"
              },
              {
                "id": "R-HSA-428559",
                "label": "Proton-coupled neutral amino acid transporters",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-428559"
              }
            ],
            "id": "R-HSA-425393",
            "label": "Transport of inorganic cations/anions and amino acids/oligopeptides",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-425393"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-549127",
                    "label": "Organic cation transport",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-549127"
                  },
                  {
                    "id": "R-HSA-561048",
                    "label": "Organic anion transport",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-561048"
                  }
                ],
                "id": "R-HSA-549132",
                "label": "Organic cation/anion/zwitterion transport",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-549132"
              },
              {
                "groups": [
                  {
                    "groups": [
                      {
                        "id": "R-HSA-435368",
                        "label": "Zinc efflux and compartmentalization by the SLC30 family",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-435368"
                      },
                      {
                        "id": "R-HSA-442380",
                        "label": "Zinc influx into cells by the SLC39 gene family",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-442380"
                      }
                    ],
                    "id": "R-HSA-435354",
                    "label": "Zinc transporters",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-435354"
                  }
                ],
                "id": "R-HSA-425410",
                "label": "Metal ion SLC transporters",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-425410"
              },
              {
                "id": "R-HSA-429593",
                "label": "Inositol transporters",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-429593"
              },
              {
                "id": "R-HSA-433137",
                "label": "Sodium-coupled sulphate, di- and tri-carboxylate transporters",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-433137"
              },
              {
                "id": "R-HSA-433692",
                "label": "Proton-coupled monocarboxylate transport",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-433692"
              },
              {
                "id": "R-HSA-442660",
                "label": "Na+/Cl- dependent neurotransmitter transporters",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-442660"
              },
              {
                "id": "R-HSA-444411",
                "label": "Rhesus glycoproteins mediate ammonium transport.",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-444411"
              }
            ],
            "id": "R-HSA-425366",
            "label": "Transport of bile salts and organic acids, metal ions and amine compounds",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-425366"
          }
        ],
        "id": "R-HSA-425407",
        "label": "SLC-mediated transmembrane transport",
        "weight": 30,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-425407"
      },
      {
        "groups": [
          {
            "id": "R-HSA-8949664",
            "label": "Processing of SMDT1",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8949664"
          }
        ],
        "id": "R-HSA-8949215",
        "label": "Mitochondrial calcium ion transport",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8949215"
      },
      {
        "groups": [
          {
            "id": "R-HSA-1237044",
            "label": "Erythrocytes take up carbon dioxide and release oxygen",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1237044"
          },
          {
            "id": "R-HSA-1247673",
            "label": "Erythrocytes take up oxygen and release carbon dioxide",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1247673"
          }
        ],
        "id": "R-HSA-1480926",
        "label": "O2/CO2 exchange in erythrocytes",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1480926"
      },
      {
        "groups": [
          {
            "groups": [
              {
                "id": "R-HSA-8866427",
                "label": "VLDLR internalisation and degradation",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8866427"
              },
              {
                "id": "R-HSA-8964038",
                "label": "LDL clearance",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8964038"
              },
              {
                "id": "R-HSA-8964026",
                "label": "Chylomicron clearance",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8964026"
              },
              {
                "id": "R-HSA-8964011",
                "label": "HDL clearance",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8964011"
              },
              {
                "id": "R-HSA-8964046",
                "label": "VLDL clearance",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8964046"
              }
            ],
            "id": "R-HSA-8964043",
            "label": "Plasma lipoprotein clearance",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8964043"
          },
          {
            "groups": [
              {
                "id": "R-HSA-8963889",
                "label": "Assembly of active LPL and LIPC lipase complexes",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8963889"
              },
              {
                "id": "R-HSA-8963901",
                "label": "Chylomicron remodeling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8963901"
              },
              {
                "id": "R-HSA-8964058",
                "label": "HDL remodeling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8964058"
              },
              {
                "id": "R-HSA-8964041",
                "label": "LDL remodeling",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8964041"
              }
            ],
            "id": "R-HSA-8963899",
            "label": "Plasma lipoprotein remodeling",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8963899"
          },
          {
            "groups": [
              {
                "id": "R-HSA-8866423",
                "label": "VLDL assembly",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8866423"
              },
              {
                "id": "R-HSA-8963896",
                "label": "HDL assembly",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8963896"
              },
              {
                "id": "R-HSA-8963888",
                "label": "Chylomicron assembly",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8963888"
              }
            ],
            "id": "R-HSA-8963898",
            "label": "Plasma lipoprotein assembly",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8963898"
          }
        ],
        "id": "R-HSA-174824",
        "label": "Plasma lipoprotein assembly, remodeling, and clearance",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-174824"
      },
      {
        "id": "R-HSA-5223345",
        "label": "Miscellaneous transport and binding events",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5223345"
      },
      {
        "groups": [
          {
            "id": "R-HSA-432047",
            "label": "Passive transport by Aquaporins",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-432047"
          },
          {
            "id": "R-HSA-432040",
            "label": "Vasopressin regulates renal water homeostasis via Aquaporins",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-432040"
          },
          {
            "id": "R-HSA-432030",
            "label": "Transport of glycerol from adipocytes to the liver by Aquaporins",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-432030"
          }
        ],
        "id": "R-HSA-445717",
        "label": "Aquaporin-mediated transport",
        "weight": 9,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-445717"
      },
      {
        "groups": [
          {
            "id": "R-HSA-1369007",
            "label": "Mitochondrial ABC transporters",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1369007"
          },
          {
            "id": "R-HSA-1369062",
            "label": "ABC transporters in lipid homeostasis",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1369062"
          }
        ],
        "id": "R-HSA-382556",
        "label": "ABC-family proteins mediated transport",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-382556"
      },
      {
        "groups": [
          {
            "id": "R-HSA-917977",
            "label": "Transferrin endocytosis and recycling",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-917977"
          }
        ],
        "id": "R-HSA-917937",
        "label": "Iron uptake and transport",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-917937"
      },
      {
        "groups": [
          {
            "groups": [
              {
                "id": "R-HSA-3295583",
                "label": "TRP channels",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3295583"
              }
            ],
            "id": "R-HSA-2672351",
            "label": "Stimuli-sensing channels",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2672351"
          },
          {
            "id": "R-HSA-936837",
            "label": "Ion transport by P-type ATPases",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-936837"
          }
        ],
        "id": "R-HSA-983712",
        "label": "Ion channel transport",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-983712"
      }
    ],
    "id": "R-HSA-382551",
    "label": "Transport of small molecules",
    "weight": 70,
    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-382551"
  },
  {
    "groups": [
      {
        "groups": [
          {
            "groups": [
              {
                "groups": [
                  {
                    "groups": [
                      {
                        "id": "R-HSA-196025",
                        "label": "Formation of annular gap junctions",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-196025"
                      }
                    ],
                    "id": "R-HSA-190873",
                    "label": "Gap junction degradation",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-190873"
                  },
                  {
                    "groups": [
                      {
                        "id": "R-HSA-190827",
                        "label": "Transport of connexins along the secretory pathway",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-190827"
                      },
                      {
                        "id": "R-HSA-190704",
                        "label": "Oligomerization of connexins into connexons",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-190704"
                      },
                      {
                        "groups": [
                          {
                            "id": "R-HSA-190840",
                            "label": "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane",
                            "weight": 9,
                            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-190840"
                          }
                        ],
                        "id": "R-HSA-190872",
                        "label": "Transport of connexons to the plasma membrane",
                        "weight": 9,
                        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-190872"
                      }
                    ],
                    "id": "R-HSA-190861",
                    "label": "Gap junction assembly",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-190861"
                  }
                ],
                "id": "R-HSA-190828",
                "label": "Gap junction trafficking",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-190828"
              },
              {
                "groups": [
                  {
                    "id": "R-HSA-191647",
                    "label": "c-src mediated regulation of Cx43 function and closure of gap junctions",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-191647"
                  }
                ],
                "id": "R-HSA-191650",
                "label": "Regulation of gap junction activity",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-191650"
              }
            ],
            "id": "R-HSA-157858",
            "label": "Gap junction trafficking and regulation",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-157858"
          },
          {
            "groups": [
              {
                "id": "R-HSA-8876198",
                "label": "RAB GEFs exchange GTP for GDP on RABs",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8876198"
              },
              {
                "id": "R-HSA-8854214",
                "label": "TBC/RABGAPs",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8854214"
              }
            ],
            "id": "R-HSA-9007101",
            "label": "Rab regulation of trafficking",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-9007101"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-6811436",
                    "label": "COPI-independent Golgi-to-ER retrograde traffic",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6811436"
                  },
                  {
                    "id": "R-HSA-6811434",
                    "label": "COPI-dependent Golgi-to-ER retrograde traffic",
                    "weight": 10,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6811434"
                  }
                ],
                "id": "R-HSA-8856688",
                "label": "Golgi-to-ER retrograde transport",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8856688"
              },
              {
                "id": "R-HSA-6811438",
                "label": "Intra-Golgi traffic",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6811438"
              },
              {
                "id": "R-HSA-6811440",
                "label": "Retrograde transport at the Trans-Golgi-Network",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6811440"
              }
            ],
            "id": "R-HSA-6811442",
            "label": "Intra-Golgi and retrograde Golgi-to-ER traffic",
            "weight": 20,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6811442"
          },
          {
            "id": "R-HSA-917729",
            "label": "Endosomal Sorting Complex Required For Transport (ESCRT)",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-917729"
          },
          {
            "groups": [
              {
                "groups": [
                  {
                    "id": "R-HSA-432722",
                    "label": "Golgi Associated Vesicle Biogenesis",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-432722"
                  },
                  {
                    "id": "R-HSA-432720",
                    "label": "Lysosome Vesicle Biogenesis",
                    "weight": 9,
                    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-432720"
                  }
                ],
                "id": "R-HSA-421837",
                "label": "Clathrin derived vesicle budding",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-421837"
              }
            ],
            "id": "R-HSA-199992",
            "label": "trans-Golgi Network Vesicle Budding",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-199992"
          },
          {
            "id": "R-HSA-1445148",
            "label": "Translocation of SLC2A4 (GLUT4) to the plasma membrane",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-1445148"
          },
          {
            "groups": [
              {
                "id": "R-HSA-6807878",
                "label": "COPI-mediated anterograde transport",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-6807878"
              },
              {
                "id": "R-HSA-5694530",
                "label": "Cargo concentration in the ER",
                "weight": 9,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5694530"
              },
              {
                "id": "R-HSA-204005",
                "label": "COPII-mediated vesicle transport",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-204005"
              }
            ],
            "id": "R-HSA-199977",
            "label": "ER to Golgi Anterograde Transport",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-199977"
          },
          {
            "groups": [
              {
                "id": "R-HSA-8856825",
                "label": "Cargo recognition for clathrin-mediated endocytosis",
                "weight": 10,
                "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8856825"
              }
            ],
            "id": "R-HSA-8856828",
            "label": "Clathrin-mediated endocytosis",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-8856828"
          }
        ],
        "id": "R-HSA-199991",
        "label": "Membrane Trafficking",
        "weight": 50,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-199991"
      },
      {
        "groups": [
          {
            "id": "R-HSA-3000497",
            "label": "Scavenging by Class H Receptors",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3000497"
          },
          {
            "id": "R-HSA-3000471",
            "label": "Scavenging by Class B Receptors",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3000471"
          },
          {
            "id": "R-HSA-3000480",
            "label": "Scavenging by Class A Receptors",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3000480"
          },
          {
            "id": "R-HSA-3000484",
            "label": "Scavenging by Class F Receptors",
            "weight": 9,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-3000484"
          },
          {
            "id": "R-HSA-2168880",
            "label": "Scavenging of heme from plasma",
            "weight": 10,
            "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2168880"
          }
        ],
        "id": "R-HSA-2173782",
        "label": "Binding and Uptake of Ligands by Scavenger Receptors",
        "weight": 10,
        "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-2173782"
      }
    ],
    "id": "R-HSA-5653656",
    "label": "Vesicle-mediated transport",
    "weight": 60,
    "url": "https://dev.reactome.org/PathwayBrowser/#/R-HSA-5653656"
  }
]