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The use of iodoacetamide implies that we are not discussing intact proteoforms as they exist in live cells, but rather the observed ones that may have sample handling artifacts.
I would argue that since this is not an issue for proteoforms in their natural form, there is no need for a special short-hand notation to emphasize "global" modifications.
acesnik
changed the title
global modifications (modifications for a specific AA over the whole sequence)
Global modifications (modifications for a specific AA over the whole sequence)
Apr 3, 2018
In MS proteomics sometimes iodoacetamide is used to break the disulfide bonds. This yield to iodoacetylated cysteine residues (Unimod:4).
Currently you have to annotated the sequence as follows:
That would be difficult and error prone for humans for long sequences (could be done by a computer and regular expressions easily).
It would be nice if there could be a prefix tag for global modifications as well. As basis for discussion I would suggest the
>
operator:Or would something like this destroy the human readability?
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