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T-164321 opened this issue Mar 25, 2025 · 0 comments
Open

The Relax analysis results in an error #1829

T-164321 opened this issue Mar 25, 2025 · 0 comments

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@T-164321
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Dear @stevenweaver @spond ,

Help me.

When I perform the Relax analysis using this command: hyphy ENV="TOLERATE_NUMERICAL_ERRORS=1;" relax --alignment sequence_ENSP00000482773.txt --tree tree_ENSP00000482773.txt --test FG --kill-zero-lengths No --output ./result/ENSP00000482773.json > ./log/ENSP00000482773.log

I am unable to obtain the .json file, and the .log file contains the following error. Now I am uploading the original data.

In the .log file, the error message is as follows:

  • Potential convergence issues due to flat likelihood surfaces; checking to see whether K > 1 or K < 1 is robustly inferred
    Error:
    fXkHOuUH.tree_id_0.GORGO.t evaluated to a NaN; this can cause all kinds of odd behavior downstream, therefore it is safer to quit now

Function call stack
1 : [namespace = fXkHOuUH] Optimize(mles, likelihoodFunction);

2 : relax.alternative_model.fit.take2=estimators.FitLF(relax.filter_names,relax.trees,relax.model_map,relax.alternative_model.fit,relax.model_object_map,{terms.run_options.retain_lf_object:TRUE,terms.run_options.optimization_log:relax.optimization_log_file("MainALT-redo-log.json")});

3 : relax.FitMainTestPair(relax.loop_passes==1);

ENSP00000482773.log
sequence_ENSP00000482773.txt
tree_ENSP00000482773.txt

Best regards,
Qinghua

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