diff --git a/Changes b/Changes
index bf45b434..a8b1121b 100644
--- a/Changes
+++ b/Changes
@@ -1,5 +1,11 @@
 LIST OF CHANGES
 
+ - update regex to discriminate crams to consider in manifest4study bin.
+   regex will look for filename patterns including:
+    - xxxxx#z.cram
+    - xxxxx_y#z.cram
+    - xxxxx_y-y#z.cram
+
 release 44.1.0
  - inital ml warehouse run data loader for pacbio data
  - move from Travis CI to GitHub Actions
diff --git a/bin/npg_manifest4study b/bin/npg_manifest4study
index 3edc13d3..befc6a67 100755
--- a/bin/npg_manifest4study
+++ b/bin/npg_manifest4study
@@ -254,7 +254,7 @@ sub _uploaded_files {
 
   while (<$fh>) {
     ##no critic (RegularExpressions::RequireExtendedFormatting RegularExpressions::ProhibitEscapedMetacharacters ProhibitComplexRegexes)
-    if ( m{(\S+/(\d+)/((\d+)(?:_(\d))?#(\d+)[.]cram)):.*Hash \(md5\):\s+(\S+)}sm ) {
+    if ( m{(\S+/(\d+)/((\d+)(?:_(\d)(?:-\d)*)?#(\d+)[.]cram)):.*Hash \(md5\):\s+(\S+)}sm ) {
       my $path      = $1;
       my $sample    = $2;
       my $file_name = $3;