Essential Easter Performance Release [EEPR]
Bismark
-
Hot-fixed (read: removed) the cause of delay during the
MD:Z:
field computation for reads containing a deletion (which was roughly equal to 1 second per read). Apologies, I did it again... -
Changed the default
--score_min
function for HISAT2 in--local
mode back to a linear function (instead of using the logarithmic model that is employed by Bowtie 2). The default is now--score_min L,0,-0.2
for both end-to-end (default) and--local
mode. It should be mentioned that we currently don't understand how exactly the scoring mode in HISAT2 works (even though the scores appear to be all negative with a maximum value of 0), so this might change somewhat in the future. See here for more info.