Our dermatology laboratory, located in Centre Hospitalier Universitaire Vaudois (CHUV) in Lausanne, Switzerland, is at the forefront of research on lymphomas and inflammatory diseases. We utilize cutting-edge technologies such as multiplexing imaging and single cell sequencing to gain a deeper understanding of the bio markers associated with these conditions. Our team is composed of skilled biologists, physicians and bioinformaticians who work in collaboration to advance our knowledge of these diseases. By integrating the latest technologies and methodologies with the expertise of our experienced researchers, we are able to make significant contributions to the field and improve the lives of patients suffering from lymphomas and inflammatory diseases. We are committed to advancing the field through our innovative research and dedicated efforts.
Image adapted from :
- Bobrowicz M., Fassnacht C., Ignatova D., Chang Y.T., Dimitriou F., Guenova E. (2020) Pathogenesis and Therapy of Primary Cutaneous T-Cell Lymphoma: Collegium Internationale Allergologicum (CIA) Update 2020. International archives of allergy and immunology. 181 (10) pp. 733-745. [10.1159/000509281] Selected publications
- Iselin C, Chang YT, Schlaepfer T, Fassnacht C, Dimitriou F, Nägeli M, Pascolo S, Hoetzenecker W, Bobrowicz M, Guenova E. (2021) Enhancement of antibody-dependent cellular cytotoxicity is associated with treatment response to extracorporeal photopheresis in Sézary syndrome. Oncoimmunology. 10 (1) p. 1873530.
- Saulite I+, Ignatova D+, Chang YT, Fassnacht C, Dimitriou F, Varypataki E, Anzengruber F, Nägeli M, Cozzio A, Dummer R, Scarisbrick J, Pascolo S, Hoetzenecker W, Bobrowicz M, and Guenova E (2020). Blockade of programmed cell death protein 1 (PD-1) in Sézary syndrome reduces Th2 phenotype of non-tumoral T lymphocytes but may enhance tumor proliferation. OncoImmunology 9, (1) p. 1738797 +Joint first authors
- Guenova E+, Watanabe R+, Teague JE, Desimone JA, Jiang Y, Dowlatshahi M, Schlapbach C, Schaekel K, Rook AH, Tawa M, Fisher DC, Kupper TS, and Clark RA (2013). Th2 cytokines from malignant cells suppress Th1 responses and enforce a global Th2 bias in leukemic cutaneous T-cell lymphoma. Clin Cancer Res, 19, 3755-3763. +Joint first authors
- Guenova E+, Skabytska Y+, Hoetzenecker W+, Weindl G, Sauer K, Tham M, Kim KW, Park JH, Seo JH, Ignatova D, Cozzio A, Levesque MP, Volz T, Köberle M, Kaesler S, Thomas P, Mailhammer R, Ghoreschi K, Schäkel K, Amarov B, Eichner M, Schaller M, Clark RA, Röcken M, and Biedermann T (2015). IL-4 abrogates TH17 cell-mediated inflammation by selective silencing of IL-23 in antigen-presenting cells. Proc Natl Acad Sci U S A 112, 2163-2138. +Joint first authors
- Hoetzenecker W+, Echtenacher B+, Guenova E+, Hoetzenecker K, Woelbing F, Brück J, Teske A, Valtcheva N, Fuchs K, Kneilling M, Park JH, Kim KH, Kim KW, Hoffmann P, Krenn C, Hai T, Ghoreschi K, Biedermann T, and Röcken M (2011). ROS-induced ATF3 causes susceptibility to secondary infections during sepsis-associated immunosuppression. Nat Med, 18, 128-123. +Joint first authors
