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Protection from Killed Whole-Cell Cholera Vaccines: A Systematic Review and Meta-Analysis

This is the repository for the manuscript titled "Protection from Killed Whole-Cell Cholera Vaccines: A Systematic Review and Meta-Analysis," by Xu and Tiffany et al (2025). This systematic review builds upon a previous systematic review by Bi et al. titled "Protection against cholera from killed whole-cell oral cholera vaccines: a systematic review and meta-analysis" published on Lancet Infectious Disease in 2017.

Data

  • ve_meansvar.csv: this file contains data included in the previous search by Bi et al. 2017. Each estimate in this file represents the pooled estimate over the study's follow-up period without stratification by time since vaccination.
  • FollowupPeriodData.csv: this file contains data included in the previous search by Bi et al. 2017. The estimates in this file are stratified by time since vaccination.
  • extracted_SR_data_2017_2024.csv: contains data detected through new search.
  • effectiveness_studies.csv, efficacy_studies.csv: contain meta-data of each included study in the current systematic review.
  • propUnder5_data.csv: contains age-stratified information on each included study.
  • QA_RCT_resolved.csv: contains the risk of bias assessment of all the included randomized clinical trials after resolving conflicts between two reviewers.

Code

  • OCV_SR_update.Rmd: code used to conduct all the analyses and generation of tables and figures presented in the manuscript.
  • panelPlot_colored.R, utils_OCV_SR.R: functions used in the OCV_SR_update.Rmd.