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Dominic Muston
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Update readme
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README.md

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for each of the 3 model structures (given a time horizon), to evaluate
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plausibility and structural sensitivity. Additional functionality:
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- Constraining the estimates to ensure that mortality survival is no greater than background mortality.
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- Constraining the estimates to ensure that mortality hazards are at
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least as great as background morality.
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- Applying discounting to obtained discounted restricted means.
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- Bootstrap standard errors can be derived.
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- Graphically illustrate observed and fitted membership probabilities,
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A second vignette, `vignette("background-mortality")` illustrates how,
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after fitting models, estimates of restricted mean durations in health
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states can be calculated after constraining for background mortality
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from a given life table. Projected survival in the modeled dataset is assumed to be no greater than background survival.
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from a given life table. This mortality is assumed to add to the
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mortality hazard observed in the dataset.
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## Installation
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application to prognostic modelling and estimation of treatment
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effects. Statistics in Medicine 21(1):2175-2197; 2002. [DOI:
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10.1002/sim.1203](https://doi.org/10.1002/sim.1203)
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