ModelDBRepository/266797
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<html> <p>Model files in the NEURON simulation environment (v8.0.0) from the paper:</p> <p><b>"T-type Ca 2+ and persistent Na + currents synergistically elevate ventral, not dorsal, entorhinal cortical stellate cell excitability. ”</b></p> <p>By Aleksandra Topczewska 1 , Elisabetta Giacalone 2 , Wendy S. Pratt 3 , Michele Migliore 2 , Annette C. Dolphin 3 and Mala M. Shah 1* . 1 Pharmacology, School of Pharmacy, University College London, WC1N 4AX UK; 2 Institute of Biophysics, National Research Council, 90146 Palermo, Italy; 3 Neuroscience, Physiology and Pharmacology, University College London, WC1E 6BT, UK. <p></p> <p>Auto-launch from ModelDB or:</p> <p>Compile the mod files with mknrndll (mswin or graphical mac) or nrnivmodl (unix/linux)). Start the simulation by (unix/linux) typing on the command line:</p> <p>nrngui mosinit.hoc</p> <p>or (mac os x) drag and dropping the mosinit.hoc file on the nrngui icon or (mswin) double clicking on the mosinit.hoc file.</p> <p><br/> <br/> </p> <p>mosinit.hoc will reproduce the simulated traces in Fig.5 of the paper.</p> <p>Click on buttons "50pA", "100pA", "200pA", "250pA" to run the simulations at different current injection in all the conditions:</p> <p><br/> - Control (black line)<p/> <p/> - No CaT (red line)<p/> <p/> - No NaP (blue line)<p/> <p/> - No CaT + No NaP (green line)<p/> <p/> Questions on how to use this model should be directed to [email protected] If you need more help running the model on your platform, please consult this page:<p/> <a href="https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide.cshtml">https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide.cshtml</a> <br/> </p> </html>