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rxu17 committed Oct 2, 2024
1 parent b68f90f commit a46e576
Showing 1 changed file with 5 additions and 5 deletions.
10 changes: 5 additions & 5 deletions genie/database_to_staging.py
Original file line number Diff line number Diff line change
Expand Up @@ -272,13 +272,13 @@ def get_whitelist_variants_idx(mafdf):
# TODO: Add to transform.py
def configure_maf(mafdf, remove_variants, flagged_variants):
"""Configures each maf dataframe, does germline filtering
Germline filtering for MAF files uses the gnomAD columns that refer to the
allele frequencies (AF) of variants in different population groups
Germline filtering for MAF files uses the gnomAD columns that refer to the
allele frequencies (AF) of variants in different population groups
from the gnomAD (Genome Aggregation Database). This filter will filter out
variants with a maximum AF > 0.05% across all populations which are typically
variants with a maximum AF > 0.05% across all populations which are typically
common germline variants.
Germline filtering for MAF files occurs during release instead of during processing
because the MAF file gets re-annotated during processing via genome nexus annotation.
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